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Sample records for balkan endemic nephropathy

  1. Associated with Balkan Endemic Nephropathy

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    Ljubinka Jankovic-Velickovic

    2011-01-01

    Full Text Available The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN and associated upper-tract urothelial carcinoma (UTUC has been recently confirmed. The aim of this study was to determine apoptosis-related marker(s specific for BEN-associated UTUC. Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors. Altered expression of Survivin was more often present in BEN UTUC with high grade and solid growth (P<0.005; P<0.05 than in control tumors. Significantly lower expression of proapoptotic marker Bax was found in BEN tumors with high grade, high stage, necrosis, and without metaplastic change (P<0.05; 0.05; 0.05; 0.05 compared to control tumors with the same features. Group (BEN-related/control, stage, growth pattern, and caspase 3 activity were significantly associated with the expression of Bax (P=0.002, 0.034, 0.047, 0.028, resp.,. This investigation identifies Bax as specific marker of BEN-associated UTUC. Decrease of pro-apoptotic protein Bax together with alteration of Survivin may be indicative for specific disturbances of intrinsic apoptotic pathway in UTUC arising in endemic areas.

  2. Testament's ability in Balkan endemic nephropathy

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    Novaković Milan

    2009-01-01

    Full Text Available Introduction Testament is a solemn, authentic instrument in writing, by which a person declares his or her will as to disposal of his or her estate, and it has a psychopathological, lawful and ethical importance to a person, family and society. The aim of the study was to assess if the ability to make a testament was more damaged in patients with Balkan Endemic Nephropathy (BEN than in patients with other diseases that resulted in Chronic Renal Failure in Bosnia and Herzegovina in the period from the 1st January 2001 to 31st December 2006. Material and methods The 753 respondents were divided into two groups in the study: BEN group (n=150 and control group made of patients with other diseases resulting in CRF (n=150. In a multicentric longitudinal study we used: adapted questionnaire from the Renal Register of Bosnia and Herzegovina, Hamilton Depression Rating Scale, and Mini-Mental State Examination. Descriptive analysis, discriminative function and regression model have been done statistically. Results In BEN group, heirs are mostly mentioned - 84.0% (t=14.391; P=0.001, and in control group: heirs - 66.6%, relatives - 43.3% (t=7.751; P=0.003, carers - 44.0% (t= 6.678 P=0.032, and institutions 10.0% (t=5.147, P=0.061. The discriminative function shows differences between BEN and control group: canonical correlation (rc =0.827, Wilkinson lambda (lnj =0.871, Chi-square test =141.575 and significance (P=0.001. The regression course of the analysis can be used for prediction of the ability to make testament for the patients on dialysis: [y=-0.95x + 15.715, and OR = 0.785, (95% for CI = -0.997 - -0.375; Can Fanc r2=0.861; Significance is P=0.002]. Conclusion The ability to make a testament is more damaged in patients from the nephropathy group than in the patients from the control group who are on dialysis in Bosnia and Herzegovina. This has been confirmed by socio-demographic and psychological parameters, and it is very important for preservation

  3. Environmental renal disease: Lead, cadmium and Balkan endemic nephropathy

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    Wedeen, R.P. (VA Medical Center, East Orange, NJ (United States))

    1991-11-01

    The similarity of lead and cadmium nephropathy to Balkan endemic nephropathy warrants careful reevaluation of the possibility that these nephrotoxic metals contribute to the production of the endemic renal disease. Low-level environmental exposure may result in a relationship between the concentration of the metals in tissue storage sites and biological fluids that differs from that encountered after occupational exposure. Urine and blood concentrations may therefore be inadequate measures of exposure. Lead is accumulated in the skeleton and cadmium in the liver and kidneys with biological half lives approximating a decade. Non-invasive in vivo x-ray fluorescence or neutron activation analysis can therefore be used to measure cumulative tissue stores. Multiple regression analysis of epidemiologic data could reveal the relative contribution of causal factors, including lead and cadmium, and help to distinguish Balkan endemic nephropathy from other renal diseases using rigorous diagnostic criteria. As long as Balkan endemic nephropathy remains a diagnosis of exclusion, the accuracy of the diagnosis of other renal disease determines the reliability of identification of the endemic disease.31 references.

  4. The continuing medical mystery of Balkan Endemic Nephropathy

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    Crosby, Lynn M.; Tatu, Calin A.; Orem, William H.; Pavlovic MD PhD, Nikola

    2015-01-01

    Balkan Endemic Nephropathy (BEN) is a disease of subtle onset and insidious progression that typically occurs between the 4th and 6th decade in long‐resident individuals in highly specific geographic locations of the Balkan region and affects 1 – 5% of the population. Though it does not follow typical Mendelian genetics, there is a familial pattern of occurrence. Although residents may live only a few kilometers apart, certain locations are highly affected while others close by, even as close as across the road, remain unscathed. Because of this geographic selectivity scientists have searched for an environmental cause. It is thought that exposure to the toxic plant Aristolochia clematitis is to blame. Genotoxic N‐heterocyclic or polycyclic aromatic containing coal water leachates entering cultivated soil and drinking water are also a possible cause due to the proximity and predictive power of endemic foci to coal deposits. Evidence for Ochratoxin A fungal poisoning also exists. High levels of phthalates have been measured in BEN‐endemic drinking water. BEN is a probably a multifactorial disease that may result from exposure through some of above‐mentioned environmental sources, with genetic factors contributing. This review will discuss recent research concerning the etiology, potential therapies for the treatment of nephropathy, and unexplored research directions for this chronic kidney disease.

  5. Etiology of Balkan endemic nephropathy and associated urothelial cancer

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    Stefanovic, V.; Toncheva, D.; Atanasova, S.; Polenakovic, M. [Inst. of Nephrology and Hemodialysis, Nish (Serbia Montenegro)

    2006-07-01

    Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression to terminal renal failure. Evidence has accumulated that BEN is an environmentally induced disease. There are three actual theories attempting to explain the environmental cause of this disease: (1) the aristolochic acid hypothesis, which considers that the disease is produced by chronic intoxication with Aristolochia, (2) the mycotoxin hypothesis, which considers that BEN is produced by ochratoxin A, and (3) the Pliocene lignite hypothesis, which proposes that the disease is caused by long-term exposure to polycyclic aromatic hydrocarbons and other toxic organic compounds leaching into the well drinking water from low-rank coals in the vicinity to the endemic settlements. Moreover, it was suggested that BEN risk is influenced by inherited susceptibility. Therefore, it has been expected that molecular biological investigations will discover genetic markers of BEN and associated urothelial cancer, permitting early identification of susceptible individuals who may be at risk of exposure to the environmental agents. Since kidney pathophysiology is complex, gene expression analysis and highly throughput proteomic technology can identify candidate genes, proteins and molecule networks that eventually could play a role in BEN development. Investigation of gene-gene and gene-environment interactions could be the content of further studies determining the precise risk for BEN.

  6. Role of exposure analysis in solving the mystery of Balkan endemic nephropathy.

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    Long, David T; Voice, Thomas C

    2007-06-01

    We evaluated the role of exposure analysis in assessing whether ochratoxin A or aristolochic acid are the agents responsible for causing Balkan endemic nephropathy. We constructed a framework for exposure analysis using the lessons learned from the study of endemic goiter within the context of an accepted general model. We used this framework to develop an exposure analysis model for Balkan endemic nephropathy, evaluated previous findings from the literature on ochratoxin A and aristolochic acid in the context of this model, discussed the strength of evidence for each, and proposed approaches to address critical outstanding questions. The pathway for exposure to ochratoxin A is well defined and there is evidence that humans have ingested ochratoxin A. Factors causing differential exposure to ochratoxin A and how ochratoxin A is implicated in Balkan endemic nephropathy are not defined. Although there is evidence of human exposure to aristolochic acid and that its effects are consistent with Balkan endemic nephropathy, a pathway for exposure to aristolochic acid has been suggested but not demonstrated. Factors causing differential exposure to aristolochic acid are not known. Exposure analysis results suggest that neither ochratoxin A nor aristolochic acid can be firmly linked to Balkan endemic nephropathy. However, this approach suggests future research directions that could provide critical evidence on exposure, which when linked with findings from the health sciences, may be able to demonstrate the cause of this disease and provide a basis for effective public health intervention strategies. One of the key unknowns for both agents is how differential exposure can occur.

  7. Beta2-Microglobulin and Alpha1-Microglobulin as Markers of Balkan Endemic Nephropathy, a Worldwide Disease

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    Stefanovic, Vladisav; Djukanovic, Ljubica; Cukuranovic, Rade; Bukvic, Danica; Lezaic, Visnja; Maric, Ivko; Ogrizovic, Sanja Simic; Jovanovic, Ivan; Vlahovic, Predrag; Pesic, Ivana; Djordjevic, Vidosava

    2011-01-01

    Background: aEuro,Urine beta2-microglobulin (beta2-MG) was mainly used as a tubular marker of Balkan endemic nephropathy (BEN) but recently alpha1-microglobulin (alpha1-MG) was proposed for the diagnosis of BEN. In this study, the potential of urine beta2-MG, alpha1-MG, albumin, and total protein in

  8. Relationship between weathered coal deposits and the etiology of Balkan endemic nephropathy

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    Feder, G.L.; Radovanovic, Z.; Finkelman, R.B.

    1991-01-01

    Field studies in epidemiology and environmental geochemistry in areas in Yugoslavia containing villages with a high incidence of Balkan endemic nephropathy (BEN), indicate a possible relationship between the presence of low-rank coal deposits and the etiology of BEN. Preliminary results from qualitative chemical analyses of drinking water from shallow farm wells indicate the presence of soluble polar aromatic and polynuclear aromatic hydrocarbons. These compounds may be derived from weathering of low-rank coals occurring in the vicinity of the endemic villages. All of the endemic villages are in alluvial valleys of tributaries to the Danube River. All except one of the clusters of endemic villages are located in the vicinity of known Pliocene age coals. Detailed sampling of the drinking waters and the nearby coals are being undertaken to identify a possible etiologic factor.

  9. Fifty years of research in Balkan endemic nephropathy: where are we now?

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    Stefanovic, V.; Polenakovic, M. [Faculty of Medicine, Nish (Serbia)

    2009-07-01

    Despite broad investigations into the possible role of genetic factors, environmental agents and immune mechanisms, the etiology of Balkan endemic nephropathy (BEN) is only partially understood. An increased incidence of upper urothelial cancer in patients with BEN and in populations from endemic settlements has been demonstrated. Genetic studies have landed support for genetic predisposition to BEN. The similarity of the morphological and clinical pattern of BEN and Chinese herbs nephropathy has raised the possibility of a common etiologic agent, aristolochic acid (AA), described in 1969 by Ivic and confirmed by a recent study of AA-DNA adducts. Ochratoxin A (OTA) is studied extensively as the etiologic agent of BEN. Weathering of low-rank coals nearby the endemic villages produces water-soluble polycyclic aromatic hydrocarbons and aromatic amines, similar to metabolic products of acetaminophen, which has a causal relationship with analgesic nephropathy. AA is confirmed as the etiologic agent of BEN; however, it may not be the sole risk factor. More research is needed on the patterns of BEN over time and between different endemic places. Therefore, it is important to test etiological hypotheses in different endemic foci, preferably as a multicentric research. An international approach to solving the etiology of BEN is needed in the coming years. The geographic correlation and presence of AA-DNA adducts in both BEN and associated urothelial cancer support the hypothesis that these diseases share a common etiology.

  10. The etiology of Balkan endemic nephropathy: Still more questions than answers

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    Tatu, C.A.; Orem, W.H.; Finkelman, R.B.; Feder, G.L.

    1998-01-01

    Balkan endemic nephropathy (BEN) has attracted increasing attention as a possible environmental disease, and a significant amount of research from complementary scientific fields has been dedicated to its etiology. There are two actual competing theories attempting to explain the cause of this kidney disease: 1) the mycotoxin hypothesis, which considers that BEN is produced by ochratoxin A ingested intermittently in small amounts by the individuals in the endemic regions, and 2) the Pliocene lignite hypothesis, which proposes that the disease is caused by long-term exposure to polycyclic aromatic hydrocarbons and other toxic organic compounds leaching into the well drinking water from low rank coals underlying or proximal to the endemic settlements. We outline the current developments and future prospects in the study of BEN and differentiate possible factors and cofactors in disease etiology.

  11. Health effects of toxic organic compounds from coal; the case Balkan endemic nephropathy (BEN)

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    Orem, W.H.; Tatu, C.A.

    2001-01-01

    Balkan endemic nephropathy (BEN) is a serious kidney disease that occurs only in clusters of rural villages located in tributary valleys of the Danube River in the Balkan Peninsula. It is believed that at least 25,000 persons are suffering from BEN or are suspected of having the disease and that the total number of people at risk may exceed 100,000. BEN was first described as a distinct medical entity in 1956, but it may have existed undescribed for many centuries. The geographic distribution of the disease has not changed significantly since the 1950's. Villages afflicted in the past continue to have cases of BEN, while villages with no history of BEN (some of which are only a few miles from affected villages) have remained free of this disease. Work by the U.S. Geological Survey and others in the early 1990's noted the close correspondence between the location of the affected villages and the occurrence of coal deposits, specifically lignites deposited in the Pliocene Epoch 5.3 million to 1.6 million years ago.

  12. Pro- and Antiapoptotic Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

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    Jankovic-Velickovic, Ljubinka; Stojnev, Slavica; Ristic-Petrovic, Ana; Dolicanin, Zana; Hattori, Takanori; Mukaisho, Kenichi; Stojanovic, Mariola; Stefanovic, Vladisav

    2011-01-01

    The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper-tract urothelial carcinoma (UTUC) has been recently confirmed. The aim of this study was to determine apoptosis-related marker(s) specific for BEN-associated UTUC. Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors. Altered expression of Survivin was more often present in BEN UTUC with high grade and solid growth (P < 0.005; P < 0.05) than in control tumors. Significantly lower expression of proapoptotic marker Bax was found in BEN tumors with high grade, high stage, necrosis, and without metaplastic change (P < 0.05; 0.05; 0.05; 0.05) compared to control tumors with the same features. Group (BEN-related/control), stage, growth pattern, and caspase 3 activity were significantly associated with the expression of Bax (P = 0.002, 0.034, 0.047, 0.028, resp.,). This investigation identifies Bax as specific marker of BEN-associated UTUC. Decrease of pro-apoptotic protein Bax together with alteration of Survivin may be indicative for specific disturbances of intrinsic apoptotic pathway in UTUC arising in endemic areas. PMID:22125429

  13. Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients

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    Lukić Ljiljana

    2012-01-01

    Full Text Available Introduction. Balkan endemic nephropathy (BEN patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective. The aim of the study was to compare the improvement of anemia in BEN patients and those with other kidney diseases during treatment with human recombinant erythropoietin (rHuEpo. Methods. The study involved 240 patients on regular hemodialysis for more than one year. Out of them 146 had BEN and 94 other kidney diseases (21 glomerulonephritis, 20 hypertension, 18 diabetes, 10 policystic kidney disease, 5 obstructive nephropathy, 18 other diseases. Treatment with rHuEpo was carried out according to European guidelines for the management of anemia. Results. Patients with BEN were older and were less frequently treated with ACEi than patients with other kidney diseases. At the onset of the study mean hemoglobin level (109.6±22.3 vs. 112.7±11.3 g/l was significantly lower, but serum ferritin level and rHuEpo dose (65.4±22.3 vs. 57.5±22.5 U/kg/week were significantly higher in BEN patients than in others. In prospective four months study these differences in hemoglobin levels and rHuEpo doses maintained. The rate of anemia improvement was examined in 15 BEN patients and 10 patients with other kidney diseases at the beginning of rHuEpo treatment. No difference in the rate of anemia improvement was found between the two groups but higher rHuEpo doses were used in BEN patients. Conclusion. Patients with BEN on regular hemodialysis had more severe anemia and required higher rHuEpo doses for maintaining target hemoglobin level.

  14. Structural and functional characteristics of urinary tract in offspring of Balkan endemic nephropathy patients

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    Radisavljević Snežana

    2010-01-01

    Full Text Available Introduction. Balkan endemic nephropathy (BEN is a familial chronic progressive tubulointerstitial disease of unknown aetiology that occurs with high prevalence in endemic rural environments of Serbia, Bosnia and Herzegovina, Croatia, Bulgaria and Romania. It has been documented only in adults. Objective. The aim of this study was to examine clinical markers of BEN in children and adolescent offspring of BEN patients. Methods. Prospective clinical trial involved two groups of children and adolescents: I consisted of 30 offspring of BEN patients and II of 29 offspring of non-BEN dialysis patients, both of them living in the same South Morava region of Serbia. All of them were healthy at the time of the investigation, not receiving any drugs. The study included personal and family history, physical examination, comprehensive laboratory analyses and renal ultrasound. Blood pressure (BP was determined by using casual BP and 24 h ABPM in subjects older than 5 years. Urinary proteins were investigated by analysing microalbumin, alfa 1 microglobulin, beta 2 microglobulin and SDS-PAGE electrophoresis. GFR was measured by estimated creatinine clearance and by serum Cystatin C concentrations. Results. There were no statistically significant differences in age, gender, history of urinary tract infections or functional voiding disorders between these two groups. All of the studied subjects had normal BP and GFR. Renal ultrasound was abnormal only in BEN offspring (6.66% as well as increased urine concentrations of microalbumin (3.3%, alpha 1 microglobulin (10% and beta 2 microglobulin (13.3% while low molecular protein (<66,000 D was prevalent in BEN compared with non- BEN offspring (21.43% vs. 3.7%. Conclusion. Renal abnormalities in offspring of BEN patients may be an early marker of BEN. This has to be confirmed in long term follow-up of a greater number of BEN paediatric offspring.

  15. Increased blood pressure in adult offspring of families with Balkan Endemic Nephropathy: a prospective study

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    Georgieva Rossitza B

    2006-08-01

    Full Text Available Abstract Background Previous studies have linked smaller kidney dimensions to increased blood pressure. However, patients with Balkan Endemic Nephropathy (BEN, whose kidneys shrink during the course of the disease, do not manifest increased blood pressure. The authors evaluated the relationship between kidney cortex width, kidney length, and blood pressure in the offspring of BEN patients and controls. Methods 102 offspring of BEN patients and 99 control offspring of non-BEN hospital patients in the Vratza District, Bulgaria, were enrolled in a prospective study and examined twice (2003/04 and 2004/05. Kidney dimensions were determined using ultrasound, blood pressure was measured, and medical information was collected. The parental disease of BEN was categorized into three groups: mother, father, or both parents. Repeated measurements were analyzed with mixed regression models. Results In all participants, a decrease in minimal kidney cortex width of 1 mm was related to an increase in systolic blood pressure of 1.4 mm Hg (p = 0.005. There was no association between kidney length and blood pressure. A maternal history of BEN was associated with an increase in systolic blood pressure of 6.7 mm Hg (p = 0.03; paternal BEN, +3.2 mm Hg (p = 0.35; or both parents affected, +9.9 mm Hg (p = 0.002. There was a similar relation of kidney cortex width and parental history of BEN with pulse pressure; however, no association with diastolic blood pressure was found. Conclusion In BEN and control offspring, a smaller kidney cortex width predisposed to higher blood pressure. Unexpectedly, a maternal history of BEN was associated with average increased systolic blood pressure in offspring.

  16. Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN

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    Wooding Stephen P

    2012-10-01

    Full Text Available Abstract Background Balkan Endemic Nephropathy (BEN is late-onset kidney disease thought to arise from chronic exposure to aristolochic acid, a phytotoxin that contaminates wheat supplies in rural areas of Eastern Europe. It has recently been demonstrated that humans are capable of perceiving aristolochic acid at concentrations below 40 nM as the result of high-affinity interactions with the TAS2R43 bitter taste receptor. Further, TAS2R43 harbors high-frequency loss-of-function mutations resulting in 50-fold variability in perception. This suggests that genetic variation in TAS2R43 might affect susceptibility to BEN, with individuals carrying functional forms of the receptor being protected by an ability to detect tainted foods. Methods To determine whether genetic variation in TAS2R43 predicts BEN susceptibility, we examined genotype-phenotype associations in a case–control study. A cohort of 88 affected and 99 control subjects from western Bulgaria were genotyped with respect to two key missense variants and a polymorphic whole-gene deletion of TAS2R43 (W35S, H212R, and wt/Δ, which are known to affect taste sensitivity to aristolochic acid. Tests for association between haplotypes and BEN status were then performed. Results Three major TAS2R43 haplotypes observed in previous studies (TAS2R43-W35/H212, -S35/R212 and –Δ were present at high frequencies (0.17, 0.36, and 0.47 respectively in our sample, and a significant association between genotype and BEN status was present (P = 0.020; odds ratio 1.18. However, contrary to expectation, BEN was positively associated with TAS2R43-W35/H212, a highly responsive allele previously shown to confer elevated bitter sensitivity to aristolochic acid, which should drive aversion but might also affect absorption, altering toxin activation. Conclusions Our findings are at strong odds with the prediction that carriers of functional alleles of TAS2R43 are protected from BEN by an ability to detect and

  17. Balkan Endemic Nephropathy - Still continuing enigma, risk assessment and underestimated hazard of joint mycotoxin exposure of animals or humans.

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    Stoev, Stoycho D

    2017-01-05

    The spreading of mycotoxic nephropathy in animals/humans was studied. The possible etiological causes provoking this nephropathy were carefully reviewed and analyzed. The natural content of the most frequent nephrotoxic mycotoxins in target feedstuffs/foods were investigated, in addition to their significance for development of renal damages in endemic areas. An estimation of the level of exposure of humans to the nephrotoxic mycotoxin, ochratoxin A (OTA), is made. The possible synergism or additive effects between some target mycotoxins in the development of nephropathy is also covered. The significance of joint mycotoxin interaction and masked mycotoxins, in addition to some newly isolated fungal toxic agents in the complicated etiology of mycotoxic nephropathy ranged in Balkan countries is discussed. The importance of some target fungal species which can induce kidney damages was evaluated. The morphological/ultrastructural, functional and toxicological similarities between human and animal nephropathy are studied. The possible hazard of low content of combinations of some target mycotoxins in food or feedstuff ingested by pigs, chickens or humans under natural conditions is evaluated and a risk assessment was made. Some different but more effective manners of prophylaxis and/or prevention against OTA contamination of feedstuffs/foods are suggested. A survey was made in regard to the best possible ways of veterinary hygiene control of OTA-exposed animals at slaughter time for preventing the entrance of OTA in commercial feedstuffs/food channels with a view to reduce the possible health hazard for humans. The economic efficacy and applicability of such preventive measures is additionally discussed and some practical suggestions are made.

  18. The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis

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    Pavlovic, N.M.; Orem, W.H.; Tatu, C.A.; Lerch, H.E.; Bunnell, J.E.; Feder, G.L.; Kostic, E.N.; Ordodi, V.L. [University of Nis, Nis (Serbia)

    2008-03-15

    Balkan endemic nephropathy (BEN) occurs in Serbia, Bulgaria, Romania, Bosnia and Herzegovina, and Croatia. BEN has been characterized as a chronic, slowly progressive renal disease of unknown etiology. In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity. We found that changes for all samples were the most prominent for the dilution category containing 90% plasma and 10% of diluting media. Water samples from BEN villages from Serbia and Romania showed higher LCAT inhibiting activity (P = 0.02) and (p = 0.003), respectively, compared to deionised water and non-endemic water. A secondary LCAT deficiency could result from this inhibitory effect of the organic compounds found in endemic water supplies and provide an ethiopathogenic basis for the development of BEN in the susceptible population.

  19. The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis

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    Pavlovic, N.M.; Orem, W.H.; Tatu, C.A.; Lerch, H.E.; Bunnell, J.E.; Feder, G.L.; Kostic, E.N.; Ordodi, V.L.

    2008-01-01

    Balkan endemic nephropathy (BEN) occurs in Serbia, Bulgaria, Romania, Bosnia and Herzegovina, and Croatia. BEN has been characterized as a chronic, slowly progressive renal disease of unknown etiology. In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity. We found that changes for all samples were the most prominent for the dilution category containing 90% plasma and 10% of diluting media. Water samples from BEN villages from Serbia and Romania showed higher LCAT inhibiting activity (p = 0.02) and (p = 0.003), respectively, compared to deionised water and non-endemic water. A secondary LCAT deficiency could result from this inhibitory effect of the organic compounds found in endemic water supplies and provide an ethiopathogenic basis for the development of BEN in the susceptible population. ?? 2007 Elsevier Ltd. All rights reserved.

  20. A possible link between Balkan endemic nephropathy and the leaching of toxic organic compounds from Pliocene lignite by groundwater: Preliminary investigation

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    Orem, W.H.; Feder, G.L.; Finkelman, R.B.

    1999-01-01

    Balkan endemic nephropathy (BEN) is a fatal kidney disease that is known to occur only in clusters of villages in alluvial valleys of tributaries of the Danube River in Bulgaria, Romania, Yugoslavia, Bosnia, and Croatia. The confinement of this disease to a specific geographic area has led to speculation that an environmental factor may be involved in the etiology of BEN. Numerous environmental factors have been suggested as causative agents for producing BEN, including toxic metals in drinking water, metal deficiency in soils of BEN areas, and environmental mycotoxins to name a few. These hypotheses have either been disproved or have failed to conclusively demonstrate a connection to the etiology of BEN, or the clustering of BEN villages. In previous work, we observed a distinct geographic relationship between the distribution of Pliocene lignites in the Balkans and BEN villages. We hypothesized that the long-term consumption of well water containing toxic organic compounds derived from the leaching of nearby Pliocene lignites by groundwater was a primary factor in the etiology of BEN. In our current work, chemical analysis using 13C nuclear magnetic resonance (13CNMR) spectroscopy indicated a high degree of organic functionality in Pliocene lignite from the Balkans, and suggested that groundwater can readily leach organic matter from these coal beds. Semi-quantitative gas chromatography/mass spectroscopy analysis of solvent extracts of groundwater from shallow wells in BEN villages indicated the presence of potentially toxic aromatic compounds, such as napthalene, fluorene, phenanthrene, and pyrene at concentrations in the ppb range. Laboratory leaching of Balkan Pliocene lignites with distilled water yielded soluble organic matter (> 500 MW) containing large amounts of aromatic structures similar to the simple/discrete aromatic compounds detected in well water from BEN villages. These preliminary results are permissive of our hypothesis and suggest that further

  1. Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

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    Tsolova Svetla

    2009-04-01

    Full Text Available Abstract Background Despite the characteristic extensive tubulointerstitial fibrosis, Balkan Endemic Nephropathy (BEN is usually considered a non-inflammatory disease. Methods We examined a marker of inflammation, C-reactive protein (CRP, in the offspring of patients with BEN, a population at risk for BEN, prior to development of established disease to determine if an inflammatory process could be identified in the early stages of the disease. In 2003/04, 102 adult offspring whose parents had BEN and a control group of 99 adult offspring of non-BEN patients were enrolled in this prospective study. This cohort was re-examined yearly for four consecutive years. Levels of serum CRP were measured in years 3 and 4 and compared between groups. The data were analyzed with mixed models. Results Compared to controls, offspring of BEN parents had statistically higher CRP levels in two consecutive years, suggestive of early inflammatory reactivity. Whenever the mother was affected by BEN (both parents, or mother only, serum CRP was significantly increased, but not if only the father had BEN. CRP was inversely related to kidney cortex width but not to markers or renal function. Conclusion Early stages of BEN may involve inflammatory processes. The observation of a maternal involvement supports the concept of fetal programming, which has been implicated in the pathogenesis of other chronic kidney diseases.

  2. Is Increased Susceptibility to Balkan Endemic Nephropathy in Carriers of Common GSTA1 (*A/*B Polymorphism Linked with the Catalytic Role of GSTA1 in Ochratoxin A Biotransformation? Serbian Case Control Study and In Silico Analysis

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    Zorica Reljic

    2014-08-01

    Full Text Available Although recent data suggest aristolochic acid as a putative cause of Balkan endemic nephropathy (BEN, evidence also exists in favor of ochratoxin A (OTA exposure as risk factor for the disease. The potential role of xenobiotic metabolizing enzymes, such as the glutathione transferases (GSTs, in OTA biotransformation is based on OTA glutathione adducts (OTHQ-SG and OTB-SG in blood and urine of BEN patients. We aimed to analyze the association between common GSTA1, GSTM1, GSTT1, and GSTP1 polymorphisms and BEN susceptibility, and thereafter performed an in silico simulation of particular GST enzymes potentially involved in OTA transformations. GSTA1, GSTM1, GSTT1 and GSTP1 genotypes were determined in 207 BEN patients and 138 non-BEN healthy individuals from endemic regions by polymerase chain reaction (PCR. Molecular modeling in silico was performed for GSTA1 protein. Among the GST polymorphisms tested, only GSTA1 was significantly associated with a higher risk of BEN. Namely, carriers of the GSTA1*B gene variant, associated with lower transcriptional activation, were at a 1.6-fold higher BEN risk than those carrying the homozygous GSTA1*A/*A genotype (OR = 1.6; p = 0.037. In in silico modeling, we found four structures, two OTB-SG and two OTHQ-SG, bound in a GSTA1 monomer. We found that GSTA1 polymorphism was associated with increased risk of BEN, and suggested, according to the in silico simulation, that GSTA1-1 might be involved in catalyzing the formation of OTHQ-SG and OTB-SG conjugates.

  3. Endemic Balkan parsnip Pastinaca hirsuta: the chemical profile of essential oils, headspace volatiles and extracts.

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    Jovanović, Snežana Č; Jovanović, Olga P; Petrović, Goran M; Stojanović, Gordana S

    2015-04-01

    The present study for the first time reports the chemical composition of the endemic Balkan parsnip Pastinaca hirsuta Pančić essential oil and headspace (HS) volatiles, obtained from fresh roots, stems, flowers and fruits, as well as fresh fruits n-hexane and diethyl ether extracts. According to GC-MS and GC-FID analyses, β-Pinene was one of the major components of the root and stem HS volatiles (50.6-24.1%). (E)-β-Ocimene was found in a significant percentage in the stem and flowers HS volatiles (31.6-57.3%). The most abundant constituent of the fruit HS, flower and fruit essential oils and both extracts was hexyl butanoate (70.5%, 31.1%, 80.4%, 47.4% and 52.7%, respectively). Apiole, accompanied by myristicin and (Z)-falcarinol, make up over 70% of the root essential oils. γ-Palmitolactone was the major component of the stem essential oils (51.9% at the flowering stage and 45.7% at the fruiting stage). Beside esters as dominant compounds, furanocoumarins were also identified in extracts. (Dis)similarity relations of examined plant samples were also investigated by the agglomerative hierarchical cluster analysis. The obtained results show there is difference in the composition of volatile components from different plant organs, while the stage of growth mainly affects the quantitative volatiles composition.

  4. Larval morphology of the Western Balkans endemic caddisflies Drusus krusniki Malicky 1981, D. vernonensis Malicky 1989, and D. vespertinus Marinković 1976 (Trichoptera, Limnephilidae, Drusinae)

    Science.gov (United States)

    KUČINIĆ, MLADEN; GRAF, WOLFRAM; VITECEK, SIMON; KERESZTES, LUJZA; BÁLINT, MIKLÓS; PAULS, STEFFEN U.

    2016-01-01

    Drusinae (Trichoptera, Limnephilidae) are highland caddisflies inhabiting high-gradient, turbulent running water and spring habitats. They are disjunctly distributed over the Eurasian mountain ranges, and the majority of species is endemic to particular mountain areas. The most diverse of three main groups of the Drusinae, the grazer clade, consists of species in which larvae feed on epiltihic biofilm and algae. In this paper we describe three previously unknown grazer-clade Drusinae larvae: Drusus krusniki Malicky 1981 (endemic to the Dinaric western Balkans), D. vernonensis Malicky 1989 (endemic to the Hellenic western Balkans), and D. vespertinus Marinković 1976 (endemic to the Dinaric western Balkans). The larvae of these species have toothless mandibles typical of the Drusinae grazer clade. Larvae and adults were unambiguously associated using molecular genetic data, i.e., the mitochondrial cytochrome oxidase I gene fragment (mtCOI3-P). Morphological characteristics of the larvae are described and the diagnostic features enabling species-level identification are illustrated. We further discuss the ecology and distribution of three Western Balkan endemic species. PMID:26985141

  5. [Congenital anomalies of the excretory system and their relationship to endemic nephropathy].

    Science.gov (United States)

    Tanchev, I

    1975-01-01

    The author has studied the congenital anomalies of the urogenital system according to the clinical data of the Nephrology Ward, District Hospital--Vratza, by means of urography, ascending pyelography and reno-vasography. A total of 1960 patients were examined and congenital anomalies of the urogenital system established in 167 (8, 5%). Congenital anomalies of the excretory system, according to the author, are more often met in females (59, 9%) as compated with males (40, 1%) and in left kidney (58, 6%) as compared with the right one (35, 9%). At the same time, the most frequent complication of renal embryopathies was established to be the inflammation process of urinary ducts and kidneys (41, 9%) urinary-calculus disease (19.1%) and endemic nephropathy (8, 9%). The combination of endemic nephropathy and congenital anomalies of the urogenital system is rare (1, 1%) and most likely by chance. The author admits that endemic nephropathy most probably is not causality with the congenital anomalies of the excretory system.

  6. «Suspects» in Etiology of Endemic Nephropathy: Aristolochic Acid versus Mycotoxins

    Directory of Open Access Journals (Sweden)

    Stjepan Pepeljnjak

    2010-06-01

    Full Text Available Despite many hypotheses that have been challenged, the etiology of endemic nephropathy (EN is still unknown. At present, the implications of aristolochic acid (AA and mycotoxins (ochratoxin A—OTA and citrinin—CIT are under debate. AA-theory is based on renal pathohistological similarities between Chinese herbs nephropathy (CHN and EN, findings of AA-DNA adducts in EN and in patients with urinary tract tumors (UTT, as well as the domination of A:T→T:A transversions in the p53 mutational spectrum of UTT patients, which corresponds with findings of such mutations in AA-treated rats. However, exposure pathways of EN residents to AA are unclear. Experimental studies attempting to deduce whether nephrotoxins OTA and CIT appear at higher frequencies or levels (or both in the food and blood or urine of EN residents support the mycotoxin theory. Also, some molecular studies revealed the presence of OTA-DNA adducts in the renal tissue of EN and UTT patients. In this review, data supporting or arguing against AA and mycotoxin theory are presented and discussed.

  7. Trends of analgesic nephropathy in two high-endemic regions with different legislation.

    Science.gov (United States)

    Michielsen, P; de Schepper, P

    2001-03-01

    Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined analgesics were also prohibited. This study compared the evolution of end-stage renal disease as a result of analgesic nephropathy (AN) in these two high-endemic regions with different legislation. In both regions, the time trend of the age-specific incidence of end-stage renal disease as a result of AN is similar in the age group 45 to 54 yr. In all age groups combined, the time trend of the percentage of AN among the patients admitted for renal replacement therapy is also similar. This finding does not support the hypothesis that non-phenacetin mixed analgesics play a significant role in the occurrence of AN.

  8. Silica Nephropathy

    Directory of Open Access Journals (Sweden)

    N Ghahramani

    2010-06-01

    Full Text Available Occupational exposure to heavy metals, organic solvents and silica is associated with a variety of renal manifestations. Improved understanding of occupational renal disease provides insight into environmental renal disease, improving knowledge of disease pathogenesis. Silica (SiO2 is an abundant mineral found in sand, rock, and soil. Workers exposed to silica include sandblasters, miners, quarry workers, masons, ceramic workers and glass manufacturers. New cases of silicosis per year have been estimated in the US to be 3600–7300. Exposure to silica has been associated with tubulointerstitial disease, immune-mediated multisystem disease, chronic kidney disease and end-stage renal disease. A rare syndrome of painful, nodular skin lesions has been described in dialysis patients with excessive levels of silicon. Balkan endemic nephropathy is postulated to be due to chronic intoxication with drinking water polluted by silicates released during soil erosion. The mechanism of silica nephrotoxicity is thought to be through direct nephrotoxicity, as well as silica-induced autoimmune diseases such as scleroderma and systemic lupus erythematosus. The renal histopathology varies from focal to crescentic and necrotizing glomerulonephritis with aneurysm formation suggestive of polyarteritis nodosa. The treatment for silica nephrotoxicity is non-specific and depends on the mechanism and stage of the disease. It is quite clear that further research is needed, particularly to elucidate the pathogenesis of silica nephropathy. Considering the importance of diagnosing exposure-related renal disease at early stages, it is imperative to obtain a thorough occupational history in all patients with renal disease, with particular emphasis on exposure to silica, heavy metals, and solvents.

  9. Herbs and hazards: risk of aristolochic acid nephropathy in Iran.

    Science.gov (United States)

    Ardalan, Mohammad Reza; Khodaie, Laleh; Nasri, Hamid; Jouyban, Abolghasem

    2015-01-01

    Herbs are usually considered as inherently harmless products. Nonetheless, various renal injuries have been reported in association with several herbs. The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid is found in Chinese slim herbs. Balkan endemic nephropathy is nowadays considered as an aristolochic acid nephropathy. Plants of Aristolochiaceae (also known as birthwort, dutchman's pipe, and somersworth) is named zaravand or chopoghak in Persian and it grows in different mountainous and rural areas of Iran. The fruit and the steam of the Aristolochiacae are named zaravand gerd (nokhod alvand) and zaravand dearaz, respectively, and have different usage in Iranian teadirional such as treatment of headache, back pain, and anxiety. Some patients with end-stage renal disease and bilateral small kidneys have a history of exposure to some herbal remedies. We need to consider the possibility of environmental toxins and even Aristolochia nephrotoxicity as a potential danger in Iran.

  10. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.

    Science.gov (United States)

    Gökmen, M Refik; Cosyns, Jean-Pierre; Arlt, Volker M; Stiborová, Marie; Phillips, David H; Schmeiser, Heinz H; Simmonds, Monique S J; Cook, H Terence; Vanherweghem, Jean-Louis; Nortier, Joëlle L; Lord, Graham M

    2013-03-19

    It has been 20 years since the first description of a rapidly progressive renal disease that is associated with the consumption of Chinese herbs containing aristolochic acid (AA) and is now termed aristolochic acid nephropathy (AAN). Recent data have shown that AA is also the primary causative agent in Balkan endemic nephropathy and associated urothelial cancer. Aristolochic acid nephropathy is associated with a high long-term risk for renal failure and urothelial cancer, and the potential worldwide population exposure is enormous. This evidence-based review of the diagnostic approach to and management of AAN draws on the authors' experience with the largest and longest-studied combined cohort of patients with this condition. It is hoped that a better understanding of the importance of this underrecognized and severe condition will improve epidemiologic, preventive, and therapeutic strategies to reduce the global burden of this disease.

  11. Des Balkans About the Balkans

    Directory of Open Access Journals (Sweden)

    Predrag Matvejević

    2012-05-01

    Full Text Available Les Balkans témoignent de contradictions géographiques et politiques, perceptibles dans le changement d’appellation des lieux au cours de l’Histoire : de la péninsule illyrienne, grecque, byzantine à la « Turquie d’Europe » plus récente. Il est resté une dénomination venue des Turcs, les « Balkans ». Cette presqu’île n’offre pas de frontières naturelles difficiles à franchir. Les délimitations des géographes et historiens sont relatives et souvent arbitraires, et donc contestées. Sa définition est difficile, car, étant associée à la progression des troupes ottomanes, cette « zone de turbulences » garde aux yeux de certains un caractère négatif. Marqués par les bouleversements telluriques et historiques, les Balkans témoignent d’une pluralité et d’une variété démographiques, ce qui pose un grand nombre de questions en termes de rapports ethniques, de constructions identitaires et territoriales. Les revendications s’appuient aussi bien sur le mythe que sur l’Histoire. L’apparition de l’État-nation a constitué dans ces régions de multiples fractures à l’image du schisme chrétien de 1054, divisant Églises et croyances, empires et pouvoirs, styles et écritures. L’islam a engendré de nouvelles oppositions ou intolérances. Les puissances étrangères sont intervenues dans ce jeu pour tenter de le stabiliser tout en déterminant leurs sphères d’influence, figeant par le jeu des traités une multitude de questions irrésolues ou conflictuelles, sans apporter de réponse durable. Cet inachevé, dans une histoire faite de partages, suscite des frustrations, et nécessite une réécriture qui tarde à se faire jour, faute d’apaisement entre les différentes sensibilités. La littérature se fait l’écho de ces situations par l’évocation de la cruauté, sous l’occupation ottomane (cf. Ivo Andrić notamment, mais aussi dans l’actualité récente. « Cet espace qui produit

  12. Balkan Vegetation Database

    NARCIS (Netherlands)

    Vassilev, Kiril; Pedashenko, Hristo; Alexandrova, Alexandra; Tashev, Alexandar; Ganeva, Anna; Gavrilova, Anna; Gradevska, Asya; Assenov, Assen; Vitkova, Antonina; Grigorov, Borislav; Gussev, Chavdar; Filipova, Eva; Aneva, Ina; Knollová, Ilona; Nikolov, Ivaylo; Georgiev, Georgi; Gogushev, Georgi; Tinchev, Georgi; Pachedjieva, Kalina; Koev, Koycho; Lyubenova, Mariyana; Dimitrov, Marius; Apostolova-Stoyanova, Nadezhda; Velev, Nikolay; Zhelev, Petar; Glogov, Plamen; Natcheva, Rayna; Tzonev, Rossen; Boch, Steffen; Hennekens, Stephan M.; Georgiev, Stoyan; Stoyanov, Stoyan; Karakiev, Todor; Kalníková, Veronika; Shivarov, Veselin; Russakova, Veska; Vulchev, Vladimir

    2016-01-01

    The Balkan Vegetation Database (BVD; GIVD ID: EU-00-019; http://www.givd.info/ID/EU-00- 019) is a regional database that consists of phytosociological relevés from different vegetation types from six countries on the Balkan Peninsula (Albania, Bosnia and Herzegovina, Bulgaria, Kosovo, Montenegro

  13. Health effects of toxic organic substances from coal: toward 'panendemic' nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Orem, W.; Tatu, C.; Pavlovic, N. (and others) [US Geological Survey (United States)

    2007-02-15

    Toxic organic compounds can be leached from coal into water supplies, and long term human exposure to these compounds may lead to disease occurrence, including cancer and renal disease. Despite these potential hazards, little is known about the impact and toxicity of organic substances derived from coal in water supplies. One example of a disease hypothesized to be linked to coal-derived toxic organic compounds in water supplies is Balkan endemic nephropathy (BEN). This paper summarises results from studies linking BEN to the leaching of toxic organic compounds from low rank (lignite) Pliocene coal deposits into water supplies of the rural villages where the disease occurs. It introduces the idea of panendemic nephropathy (PEN) for BEN-like diseases that are linked to coal-derived toxic organic compounds in water supplies, but that occur outside outside the Balkans. Preliminary results supporting the PEN hypothesis are presented, with results from proposed PEN areas in Wyoming and Louisiana. Results of toxicological studies of the effects of organic compounds isolated from water supplies in BEN and PEN areas on human cell cultures are also discussed. China, India, Turkey and Portugal represent other areas where BEN-like diseases may occur, as a result of the presence of extensive low rank coal deposits and rural populations using untreated water in contact with coal in these nations. 31 refs., 2 figs.

  14. Karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of Ochratoxin A and possible genetic predisposition.

    Science.gov (United States)

    Hassen, Wafa; Abid-Essafi, Salwa; Achour, Abdellatif; Guezzah, Noureddine; Zakhama, Abdelfettah; Ellouz, Farielle; Creppy, Edmond E; Bacha, Hassen

    2004-07-01

    Karyomegalic nephropathy associated to bizarre enlargement of nuclei in renal tubular epithelial cells was first described by Mihatch in 1979. We present herein additional cases occurring in three siblings suffering from chronic interstitial nephropathy (CIN) of unknown aetiology where the renal biopsies showed numerous enlarged and hyperchromatic nuclei. CIN of unknown aetiology has been previously characterized and showed striking similarities with Balkan Endemic Nephropathy (BEN). Ochratoxin A (OTA) is a nephrotoxic mycotoxin suspected to be the causal agent of the BEN as well as the Tunisian CIN of unknown aetiology. OTA is incriminated in the onset of these disclosed cases of karyomegalic nephropathy since high OTA concentrations were found in blood (505.83 ng/ml, 102.63 ng/ml and 1023 ng/ml) and in urine (94.40 ng/ml and 10.18 ng/ml) of two of them. Moreover, we have investigated OTA in blood and urine as well as in food samples of the entire household (21 people). Our findings suggest (i) a link between OTA and the outcome of this karyomegalic nephropathy, and (ii) the possible involvement of a genetic factor since the three cases have the same haplotype B27/35.

  15. The endemic flora of Greece

    DEFF Research Database (Denmark)

    Tan, Kit

    2007-01-01

    The Balkan Peninsula has a rich endemic flora estimated as between 2600 and 2700 taxa; c. 750 are restricted to Greece. Conservationists consider the endemic flora of a country needs protection for all time; there is a tendency to paint an alarming picture. However, unless one knows something...... or quite a lot about the plants, no intelligent steps can be taken towards protecting them. 520 of the c. 750 endemics are listed on the Red Data "endangered list" by the Council of Europe in 1986 but few know the nature or extent of the threat. Work is currently in preparation on an Endemic Flora...

  16. Carpathian-Balkan Geological Association

    Institute of Scientific and Technical Information of China (English)

    Aleksandar Grubic

    2006-01-01

    @@ Carpathian-Balkan Geological Association (CBGA), according to its Statute, "is non-governmental, international, scientific, non-political and non-profit making union of geoscientists working in the Carpathian-Balkan realm" and surrounding areas. The membership of CBGA is collective and it is "open to geoscientists of all countries of the Carpathian-Balkan" and neighboring countries. Application of collective membership "should be submitted by competent scientific bodies".

  17. Membranous nephropathy

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/000472.htm Membranous nephropathy To use the sharing features on this page, please enable JavaScript. Membranous nephropathy is a kidney disorder that leads to changes ...

  18. Solar heat for Balkan residents

    Energy Technology Data Exchange (ETDEWEB)

    Frey, Martin

    2011-07-01

    On the Balkan Peninsula, solar thermal has seen limited use. The war in the former Yugoslavia and its after-effects has severely curtailed development. Nevertheless, there are some very promising initial projects. (orig.)

  19. Radiogenic nephropathy; Radiogene Nephropathie

    Energy Technology Data Exchange (ETDEWEB)

    Gotthardt, M. [Univ. Medisch Centrum St Radboud, Nijmegen (Netherlands). Nucleaire Geneeskunde

    2010-07-01

    Patient-individual dosimetric analyses are a useful tool in external beam radiotherapy (EBR) to protect patients from side effects such as radiogenic nephropathy. At this point in time, individual dosimetry is not used as a standard in patient treated with radiolabelled antibody fragments or polypeptides. The reasons are a number of problems, which make patient dosimetry more challenging than in EBR. While in EBR, the dose is distributed evenly in the organ and the organ volume can exactly be determined, in internal radiotherapy the tracer is not evenly distributed within the organ leading to a non-uniform dose distribution. In addition, the dose rate of the most commonly used radionuclides is lower than in EBR and the range of their radiation differ, so that the radiobiological effects are differing considerably in comparison to EBR. Conclusion: More complex models have to be used for clinical kidney dosimetry in internal radiotherapy. In this paper, we give a concise overview of the reasons for accumulation of radiotracers in the kidney, the most recent developments in kidney dosimetry, and approaches to reduce the kidney uptake of radiotracers in order to avoid radiogenic nephropathy. (orig.)

  20. Diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Zelmanovitz Themis

    2009-09-01

    Full Text Available Abstract Diabetic nephropathy is the leading cause of chronic renal disease and a major cause of cardiovascular mortality. Diabetic nephropathy has been categorized into stages: microalbuminuria and macroalbuminuria. The cut-off values of micro- and macroalbuminuria are arbitrary and their values have been questioned. Subjects in the upper-normal range of albuminuria seem to be at high risk of progression to micro- or macroalbuminuria and they also had a higher blood pressure than normoalbuminuric subjects in the lower normoalbuminuria range. Diabetic nephropathy screening is made by measuring albumin in spot urine. If abnormal, it should be confirmed in two out three samples collected in a three to six-months interval. Additionally, it is recommended that glomerular filtration rate be routinely estimated for appropriate screening of nephropathy, because some patients present a decreased glomerular filtration rate when urine albumin values are in the normal range. The two main risk factors for diabetic nephropathy are hyperglycemia and arterial hypertension, but the genetic susceptibility in both type 1 and type 2 diabetes is of great importance. Other risk factors are smoking, dyslipidemia, proteinuria, glomerular hyperfiltration and dietary factors. Nephropathy is pathologically characterized in individuals with type 1 diabetes by thickening of glomerular and tubular basal membranes, with progressive mesangial expansion (diffuse or nodular leading to progressive reduction of glomerular filtration surface. Concurrent interstitial morphological alterations and hyalinization of afferent and efferent glomerular arterioles also occur. Podocytes abnormalities also appear to be involved in the glomerulosclerosis process. In patients with type 2 diabetes, renal lesions are heterogeneous and more complex than in individuals with type 1 diabetes. Treatment of diabetic nephropathy is based on a multiple risk factor approach, and the goal is retarding the

  1. ON THE ORIGIN OF THE BALKAN PENINSULA SALMONIDS

    Directory of Open Access Journals (Sweden)

    Simo Georgiev

    2003-12-01

    Full Text Available This paper puts forward the knowledge of the immigration itineraries of the ancestors of five extant salmonid species on Balkan Peninsula which are the following: Acantholingua ohridana (Steindachner, 1892, Hucho hucho (Linnaeus, 1758, Salmo trutta Linnaeus, 1758, Salmothymus obtusirostris Heckel, 1851 and Thymallus thymallus (Linnaeus, 1758. The thesis for the migration itineraries is based on the anatomical, molecular and zoogeographical facts recently published. These latest facts complement or reject the previous thesis that considered the origin of separate species, which in this paper are analyzed together. A new position on the origin of some S. trutta populations inhabiting the Mediterranean Sea watershed is proposed. The new thesis is that they did not inhabit it from the west, through the Atlantic Ocean and Gibraltar, but from the North, through the branches of the former Sarmatian Sea, using the continental way. A. ohridana and S. obtusirostris, the only endemic Balkanean salmonids, have developed here from the mutual ancestor with the extant Siberian Brachymystax lenok (Pallas, 1773. This ancestor came first, together with the S. trutta lineage known as »marmorata«. Using the same migration way, the T. thymallus population of Soča River, the North.West boundary of Balkan Peninsula remained restricted at that corner of Adriatic Sea watershed. In the Black Sea watershed (the Danube River flow extension on Balkan Peninsula the distribution of T. thymallus coincides with the distribution of H. hucho. The thesis which has been proposed for this, largest contemporary Balkan Peninsula salmonid fish was that it came here last, after the connections between the Mediterranean Sea basin and once existent Sarmatian Sea disappeared. This occurred after the end of the last glaciations. This has been concluded on the basis of the exclusion of the areas of the »marmorata« lineage of S. trutta (Mediterranean Sea watershed and H. hucho (Black Sea

  2. [Analgesic nephropathy].

    Science.gov (United States)

    Pintér, I; Nagy, J

    1998-11-22

    Analgesic nephropathy is a slowly progressive disease caused by the chronic abuse of analgesic mixtures containing two analgesic components combined with potentially addictive substances (coffeine and/or codeine). Pathologically, the nephropathy is characterized by renal papillary necrosis with calcification and chronic interstitial nephritis sometimes in association with transitional-cell carcinoma of the uroepithelium. In the early stage, the clinical characteristics are polyuria, sterile pyuria, sometimes renal colic and haematuria. With further progression of the disease, there are the nonspecific symptoms of advanced renal failure. The incidence of classic analgesic nephropathy among Hungarian patients on chronic renal replacement therapy has proven. There is an urgent need for the estimation of analgesic nephropathy among patients with chronic renal disease and among patients with chronic pain presumably regularly taking analgesics in Hungary. As long as analgesic mixtures containing phenacetin or paracetamol and/or nonsteroidal antiinflammatory drugs and addictive substances are available "over-the-counter", analgesic nephropathy will continue to be a problem also in our country.

  3. (Reconstructing Balkan Identities through Popular Music

    Directory of Open Access Journals (Sweden)

    Marin Cvitanović

    2009-12-01

    Full Text Available The paper deals with the reproduction of stereotypes about the Balkans in the popular music of ex-Yugoslavia. During the last two decades, over a hundred songs in the Serbian and Croatian languages have been released, specifically mentioning the term Balkan and using it as a metaphor – to evoke and explain the atmosphere of war, poverty, conflict and passion, beauty, love and pride. Based on the analysis of these texts and the frequency of appearance of the themes and motifs, four distinct discourses can be identified: 1. the Balkans as an area of wars and conflicts, 2. the Balkans as an area of joy, passion and fatalism, 3. the primitive and aggressive “male” Balkans vs. the beautiful, proud and resistant “female” Balkans, and 4. the Balkans as Europe’s “Other”. The results show that, despite the inherent fluidity and the unclearness of the very definition of the Balkans and its spatial coverage (and therefore the possibility of distancing oneself from it, mostly negative stereotypes about the Balkans are being reproduced. They are not questioned in that process, but accepted and affirmed as a part of one’s own identity.

  4. Feminist troubles with the Balkans

    Directory of Open Access Journals (Sweden)

    Drezgić Rada

    2005-01-01

    Full Text Available The paper analyses writings of Slavenka Drakulić and certain number of other feminist writers from ex-Yugoslavia aiming to answer to the following questions: first, how much and in what way the discourses on ex-Yugoslavia Balkans, (postsocialism, nationalism and war have been produced by local feminists and/or imported from the West; second, have these discourses been overlapping with local feminist discourses about masculinity and femininity and how.

  5. Lattice QCD and the Balkan physicists contribution

    CERN Document Server

    Borici, Artan

    2015-01-01

    This is a paper based on the invited talk the author gave at the 9th Balkan Physical Union conference. It contains some of the main achievements of lattice QCD simulations followed by a list of Balkan physicists who have contributed to the project.

  6. IgA Nephropathy

    Science.gov (United States)

    ... reliable ways to diagnose IgA nephropathy; therefore, the diagnosis of IgA nephropathy requires a kidney biopsy. A kidney biopsy is ... reliable ways to diagnose IgA nephropathy; therefore, the diagnosis of IgA nephropathy requires a kidney biopsy. Researchers have not yet ...

  7. Western Balkans as Base for Radical Islamists

    Science.gov (United States)

    2011-06-10

    from Algeria to Afghanistan and were led by an Algerian known as Abu Maali.69 This unit was attached to the Bosnian government army. During the...the Balkans Wars: Ten years after the breakup of Yugoslavia, ed. Jeffrey S. Morton, R. Craig Nation, Paul Forage , and Stefano Bianchini (New York...Bianchini, Reflections on the Balkans Wars: Ten years after the breakup of Yugoslavia, ed. Jeffrey S. Morton, R. Craig Nation, Paul Forage , and

  8. [Lithium nephropathy].

    Science.gov (United States)

    Kaczmarczyk, Ireneusz; Sułowicz, Władysław

    2013-01-01

    Lithium salts are the first-line drug therapy in the treatment of uni- and bipolar disorder since the sixties of the twentieth century. In the mid-70s, the first information about their nephrotoxicity appeared. Lithium salts have a narrow therapeutic index. Side effects during treatment are polyuria, polydipsia and nephrogenic diabetes insipidus. Accidental intoxication can cause acute renal failure requiring renal replacement therapy while receiving long-term lithium salt can lead to the development of chronic kidney disease. The renal biopsy changes revealed a type of chronic tubulointerstitial nephropathy. The imaging studies revealed the presence of numerous symmetric microcysts. Care of the patient receiving lithium should include regular determination of serum creatinine, creatinine clearance and monitoring of urine volume. In case of deterioration of renal function reducing the dose should be considered.

  9. Karyosystematics and molecular taxonomy of the anomalous blue butterflies (Lepidoptera, Lycaenidae) from the Balkan Peninsula

    Science.gov (United States)

    Vishnevskaya, Maria S.; Saifitdinova, Alsu F.; Lukhtanov, Vladimir A.

    2016-01-01

    Abstract The Balkan Peninsula represents one of the hottest biodiversity spots in Europe. However, the invertebrate fauna of this region is still insufficiently investigated, even in respect of such well-studied organisms as Lepidoptera. Here we use a combination of chromosomal, molecular and morphological markers to rearrange the group of so-called anomalous blue butterflies (also known as ‘brown complex’ of the subgenus Agrodiaetus Hübner, [1822] and as the Polyommatus (Agrodiaetus) admetus (Esper, 1783) species group) and to reveal its cryptic taxonomic structure. We demonstrate that Polyommatus aroaniensis (Brown, 1976) is not as widespread in the Balkans as was previously thought. In fact, it has a dot-like distribution range restricted to the Peloponnese Peninsula in South Greece. Polyommatus orphicus Kolev, 2005 is not as closely related to the Turkish species Polyommatus dantchenkoi (Lukhtanov & Wiemers, 2003) as was supposed earlier. Instead, it is a Balkan endemic represented by two subspecies: Polyommatus orphicus orphicus (Bulgaria) and Polyommatus orphicus eleniae Coutsis & De Prins, 2005 (Northern Greece). Polyommatus ripartii (Freyer, 1830) is represented in the Balkans by an endemic subspecies Polyommatus ripartii pelopi. The traditionally recognized Polyommatus admetus (Esper, 1783) is shown to be a heterogeneous complex and is divided into Polyommatus admetus sensu stricto (the Balkans and west Turkey) and Polyommatus yeranyani (Dantchenko & Lukhtanov, 2005) (east Turkey, Armenia, Azerbaijan and Iran). Polyommatus nephohiptamenos (Brown & Coutsis, 1978) is confirmed to be a species with a dot-like distribution range in Northern Greece. Finally, from Central Greece (Timfristos and Parnassos mountains) we describe Polyommatus timfristos Lukhtanov, Vishnevskaya & Shapoval, sp. n. which differs by its haploid chromosome number (n=38) from the closely related and morphologically similar Polyommatus aroaniensis (n=47-48) and Polyommatus orphicus (n

  10. Intercultural and Interreligious Communication in the Balkan

    Directory of Open Access Journals (Sweden)

    Arta Musaraj

    2013-01-01

    Full Text Available The desire to belong in a individual culture means to possess a clear vision for the world, a road map that guides its followers towards the proper understanding of the planet’s past present and future. An established mythology of apparent national identities in the Balkans is somewhat unnaturally reinforced to justify conflicts between religious and ethnic groups, caused as a result of the national identities intertwined among themselves, an element essentially more influential than existence of national identities. For centuries Christians and Muslims in the Balkans have been living in peace, however a few Balkan Societies continue to use violence, national extremism, xenophobia as well as a contemporary practice to solve their problems. A legitimate question can be raised in relation to how common is religious influence used to cause violent and armed conflicts as compared to violence originating from ethnic cleansing, control over territory, political ideology and regional hegemony?

  11. Islam, Etnicity and the State: the Balkans

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    Ružica Čičak-Chand

    1999-10-01

    Full Text Available The paper examines Muslim identity in the context of interaction between religions and ethnic and national identities within the complex ethnic and religious network of the Balkans, and with a focus on Muslim minority communities in the individual states in the region. Although it proceeds from a historical background, emphasis is placed on contemporary conditions, especially after the fall of communism and the crisis in former Yugoslavia. The paper is based on the book Muslim Identity and the Balkan State, prepared by Hugh Poulton and Suha Taji Farouki and published in London in 1977. Apart from a valuable and interesting introduction in regard to defining the concept of “Muslim” and “Muslim community” in the Balkans, and also an indication of some of the specificities of Islam in this region, the book includes eleven separate studies, the majority of which deal with Muslim minority communities and their status in Balkan countries (Albania, Bulgaria, Greece, Kosovo, Macedonia and Sandţak. The papers also deal with Turkey, as the country whose communities reside in some of the mentioned countries, as well as with the relations between Turkey and the Balkan countries. Besides analysing the historical causes leading to the formation of the Muslim communities, each author attempted to identify the main socio-economic, political and ethno-religious factors “responsible” for their position in the individual political communities in the Balkans. In this paper, the key aspects of the mentioned themes are reviewed, including particular comments on Albania, Bulgaria, Greece, Kosovo and Macedonia.

  12. Crystalglobulin-induced nephropathy.

    Science.gov (United States)

    Gupta, Vinay; El Ters, Mireille; Kashani, Kianoush; Leung, Nelson; Nasr, Samih H

    2015-03-01

    Crystalline nephropathy refers to renal parenchymal deposition of crystals leading to kidney damage. The most common forms of crystalline nephropathy encountered in renal pathology are nephrocalcinosis and oxalate nephropathy. Less frequent types include urate nephropathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e.g., caused by indinavir or triamterene). Monoclonal proteins can also deposit in the kidney as crystals and cause tissue damage. This occurs in conditions such as light chain proximal tubulopathy, crystal-storing histiocytosis, and crystalglobulinemia. The latter is a rare complication of multiple myeloma that results from crystallization of monoclonal proteins in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. In this report, we describe a case of crystalglobulin-induced nephropathy and discuss its pathophysiology and the differential diagnosis of paraprotein-induced crystalline nephropathy.

  13. War in the Balkans, 1991-2002

    Science.gov (United States)

    2003-08-01

    See, for example, Mario Vargas Llosa , “La Guerra inútil,” El Pais, May 17, 1999, p. 4. 110. For an assessment of efforts to suppress the Yugoslav...1985. 23. Martin L. Van Crefeld, Hitler’s Strategy 1940-1941: The Balkan Clue, Cambridge: Cambridge University Press, 1973. 24. Mario Cervi, The

  14. Description of a new species of Wormaldia from Sardinia and a new Drusus species from the Western Balkans (Trichoptera, Philopotamidae, Limnephilidae

    Directory of Open Access Journals (Sweden)

    Simon Vitecek

    2015-04-01

    Full Text Available New species are described in the genera Wormaldia (Trichoptera, Philopotamidae and Drusus (Trichoptera, Limnephilidae, Drusinae. Additionally, the larva of the new species Drusus crenophylax sp. n. is described, and a key provided to larval Drusus species of the bosnicus-group, in which the new species belongs. Observations on the threats to regional freshwater biodiversity and caddisfly endemism are discussed. The new species Wormaldia sarda sp. n. is an endemic of the Tyrrhenian island of Sardinia and differs most conspicuously from its congeners in the shape of segment X, which is trilobate in lateral view. The new species Drusus crenophylax sp. n. is a micro-endemic of the Western Balkans, and increases the endemism rate of Balkan Drusinae to 79% of 39 species. Compared to other Western Balkan Drusus, males of the new species are morphologically most similar to D. discophorus Radovanovic and D. vernonensis Malicky, but differ in the shape of superior and intermediate appendages. The females of D. crenophylax sp. n. are most similar to those of D. vernonensis, but differ distinctly in the outline of segment X. Larvae of D. crenophylax sp. n. exhibit toothless mandibles, indicating a scraping grazing-feeding ecology.

  15. Nationalism and Ethnic Conflict in Southern Balkans

    Science.gov (United States)

    2002-06-01

    Balkan Peninsula. The old inhabitants simply took on the new culture and by adopting new tools and a new religion from the newcomers created a mix...18-19. 9 Davies, Norman, 1996, p. 102. 10 division that lasted for the next 200 years (Pax Romana ). Under the Roman Empire the results of rule...used in the rest of this study. Nation is a large social group, which usually has all or the most of the following shared: language, religion , myths

  16. Intercultural and Interreligious Communication in the Balkan

    OpenAIRE

    Arta Musaraj

    2013-01-01

    The desire to belong in a individual culture means to possess a clear vision for the world, a road map that guides its followers towards the proper understanding of the planet’s past present and future. An established mythology of apparent national identities in the Balkans is somewhat unnaturally reinforced to justify conflicts between religious and ethnic groups, caused as a result of the national identities intertwined among themselves, an element essentially more influential than existenc...

  17. Balkan variations of Orientalism and Occidentalism

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    Nikolay Aretov

    2014-09-01

    Full Text Available Summarizing, the aim of this paper was to provoke scrutinizing in a Balkan context the notions of Orientalism and Occidentalism – two forms of demonizing the Other, coined in the age of Enlightenment, two phenomena that are ambivalent and imported from other cultures. They interact in a curious manner and took critical place in the mythologues of all the nations in the region although in different ways.

  18. Experiences from the Balkans. What Truly Happens When Exporting Democracy

    OpenAIRE

    Steve Sampson

    2013-01-01

    This paper discusses the impact of the Western assistance for democracy in the Balkans (Eastern Europe), as civil society development programs. The analysis of the situation in the Balkans leads to the conclusion that the main consequence of this Western assistance has not been the export of democracy, but the increased capacity of the receptors (NGOs) to implement such programs.

  19. Preservation of Scientific and Cultural Heritage in Balkan Countries

    Science.gov (United States)

    Tonta, Yasar

    2009-01-01

    Purpose: The peoples living in the Balkan Peninsula over centuries have created a very rich cultural heritage and the constant political upheavals in the region have affected the development and preservation of their cultures. This paper aims to review the internet infrastructure and networked readiness levels of the Balkan countries, which are…

  20. A third Balkan war: France and the allied attempts at creating a new Balkan alliance 1914-1915

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    Pavlović Vojislav

    2007-01-01

    Full Text Available The initial phase of the First World War in the Balkans 1914-1915 was a natural continuation of the conflicts opened during the Balkan Wars, but national fervor now encompassed all of the Balkans, from Rijeka and Ljubljana to Athens, Sofia and Bucharest, because the role of the Dual Monarchy had changed from that of an arbiter to that of a participant in the conflict. With the demise of the Ottoman Empire, the further survival of the Habsburg Monarchy was challenged by the Serbian government's Yugoslav project, creating conditions for implementing the nationality principle in all of the Balkans. It seemed that, in support of the alliances that were being created in the Balkans and in Europe as a whole, the time had come for the final fulfillment of the national aspirations of the Balkan peoples. The outcome of this third Balkan war no longer depended solely on the balance of power inside the Balkans, but also on the overall course of the war. After the initial victories in 1914, Serbia suffered a defeat in 1915 and her armies were forced to retreat southward to Albania and Greece, but her Yugoslav project was the foundation of her future policies and the basis for materializing the concept of a common South-Slavic state.

  1. Kidney Disease (Nephropathy)

    Science.gov (United States)

    ... Text Size: A A A Listen En Español Kidney Disease (Nephropathy) Kidneys are remarkable organs. Inside them ... resulting in kidney disease. How Does Diabetes Cause Kidney Disease? When our bodies digest the protein we ...

  2. Proliferative retinopathy predicts nephropathy

    DEFF Research Database (Denmark)

    Karlberg, Charlotte; Falk, Christine; Green, Anders;

    2012-01-01

    We wanted to examine proliferative retinopathy as a marker of incident nephropathy in a 25-year follow-up study of a population-based cohort of Danish type 1 diabetic patients and to examine cross-sectional associations between nephropathy and retinopathy in long-term surviving patients of the same...... photographs at follow-up. Single spot urine was used to evaluate nephropathy at both examinations. Proliferative retinopathy was present in 29 patients (15.8%) at baseline. At follow-up, these patients were more likely to macroalbuminuria (20.7% vs. 6.5%) than patients without proliferative retinopathy...... at baseline. In a multivariate logistic regression adjusted for baseline age, sex, duration of diabetes, smoking, HbA(1,) systolic and diastolic blood pressure, odds ratio of nephropathy (micro- and macroalbuminuria combined) was 2.98 (95% confidence interval 1.18-7.51, p = 0.02) for patients...

  3. Folk Calendars in the Balkan Region

    Science.gov (United States)

    Kolev, Dimiter

    Folk calendars are a good source for studying the knowledge and rituals of peoples from distant epochs. The turbulent history of the cultures in the Balkan Peninsula leads to a mixture of calendar traditions - different calendar types and naming systems of the calendar units (months and weekdays). Despite the differences, they share a common astronomical basis and the seasonal structure is of fundamental importance (i.e., dividing the year into two economic seasons - warm and cold). The Old Bulgarian 12-year calendar is also mentioned briefly.

  4. Aristotle vs. Plato: The Balkans' Paradoxical Enlightenment

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    D. Michalopoulos

    2007-09-01

    Full Text Available As it occurred in West, Aristotle’s thought was in Byzantium the main organon of philosophical meditation within the frame of the Christian Faith. Nonetheless, from the ninth century on it was a revival of Platonism that took place – of Neo-Platonism at the beginning and of Platonism itself at the end. The Church, initially indifferent, became suspicious only when, at the turning of the fourteenth to the fifteenth century, the Platonism seemed to engender somewhat a latent paganism; but the Patriarchate was not then able to fight that tendency. So only after the 1453 capture of Constantinople by the Ottomans, Gennadius Scholarius managed to root out from the Greek lands Platonism and its crypto-pagan extension. Be that as it may; the main paradox of the Balkan history is that in the early seventeenth century some leading Greek scholars endorsed the materialist interpretation of Aristotle’s thought – as it was taught in the University of Padua by Cesare Cremonini; and as a corollary this materialistic philosophical system began being taught in both Constantinople and Athens. It was that very way that the Enlightenment took birth in the Balkans – and somehow became a State ideology - long before its prevalence in France. And of course all this had as a result a turn toward Physics and Chemistry with far-reaching consequences

  5. INVESTMENTS AND INVESTMENT INCENTIVES IN THE BALKAN STATES

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    MEHMET YÜCE

    2016-04-01

    Full Text Available Balkan region, located in the south eastern part of the European Continent, is composed Albania, Bosnia and Herzegovina, Bulgaria, Montenegro, Kosovo, Macedonia, Greece with a portion of the Croatia, Romania, Serbia, Slovenia and Turkey. Southeast Europe are composed of Slovenia, Croatia, Bosnia and Herzegovina, Serbia, Montenegro, Kosovo, Macedonia and Albania which known as the Western Balkans countries. That international investments are assessed on a regional and global scale in the Balkans, these investments gained importance after the 1990s with political, social and geographical variation. In the 2000s, after legal and administrative framework oriented reforms of investments which are continuations of global integration efforts, development of the investment opportunities in Balkans have been considered positively. While the investment incentive structures and rates differ on the basis of the countries, they are of capital importance for investors. After the 2008 global economic crisis which has happened because of the economic shrinkage on global scale, despite the worries for political and economic unsteadiness in specific countries, development of investments in Balkans has not been affected in a negative way. In this study development of investment in Balkans is analysed with negative and positive factors, investment opportunities and incentives are examined on the basis of countries. The Balkans gain acceleration positively thanks to the reforms of investment opportunities on the national scope. As to the need of investment development oriented local and international coordinated programme and approach is an important issue that should be analysed.

  6. The wolf (Canis lupus) as an indicator species for the sylvatic Trichinella cycle in the Central Balkans.

    Science.gov (United States)

    Teodorović, Vlado; Vasilev, Dragan; Ćirović, Duško; Marković, Marija; Ćosić, Nada; Djurić, Spomenka; Djurković-Djaković, Olgica

    2014-10-01

    Wildlife is the most important reservoir of Trichinella spp. worldwide. Although the Balkans are a recognized European endemic region for Trichinella infections, data on wildlife are scarce. To monitor the circulation of these zoonotic parasites in the Central Balkan region, the wolf (Canis lupus) was selected because of its abundance (>2,000 individuals) and because it is at the top of the food chain. A total of 116 carcasses of wolves were collected in Serbia and in the neighboring areas of Macedonia and Bosnia and Herzegovina (B&H) between 2006 and 2013. Trichinella spp. larvae were found in 54 (46.5%) wolves. The great majority (90.5%) originated from Serbia, where 52 of the 105 examined animals were Trichinella positive (49.5%; 95% confidence interval  =39.9-59.1). One positive animal each was found in B&H and Macedonia. All larvae were identified as Trichinella britovi. The high prevalence of Trichinella infection in wolves suggests that this carnivore can be a good indicator species for the risk assessment of the sylvatic Trichinella cycle in the Central Balkans.

  7. Prediction of current species distribution of Cheilosia proxima group (Diptera: Syrphidae on the Balkan peninsula

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    Milić Dubravka M.

    2013-01-01

    Full Text Available Predicting species distribution in different climates is most often made by climate models (“climate envelope models” - CEM which are using the current geographical distribution of species and climate characteristics of the area. Hoverflies (Insecta: Diptera: Syrphidae can act as bioindicators and monitors of climate change and habitat quality. Cheilosia Meigen, 1822 is one of the largest hoverflies genera, with about 450 described species. The aim of this study was to model the current potential distribution of six species from Cheilosia proxima group on the Balkan Peninsula (Cheilosia aerea Dufour, 1848, C. balkana Vujić, 1994, C. gigantea Zetterstedt, 1838, C. pascuorum Becker, 1894, C. proxima Zetterstedt, 1843 and C. rufimana Becker, 1894 using maximum entropy modeling (Maxent. It is observed that parameters with highest influence on the analyzed species are Altitude and BIO 15 (Precipitation Seasonality for all species, except C. rufimana. Parameter that also substantially influenced for all species, except C. pascuorum, is BIO 18 (Precipitation of Warmest Quarter. The models of current distribution have shown that the most important area of the Balkan Peninsula, for species from Cheilosia proxima group, is Dinaric mountains. Information obtained in this paper can help in future monitoring of species, as well as for the conservation measures, especially for endemics and rare species. [Projekat Ministarstva nauke Republike Srbije, br. 173002 i br. 43002

  8. OBSTRUCTIVE NEPHROPATHY: ITS PHYSIOPATHOLOGY

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    Musso C

    2011-01-01

    Full Text Available Obstructive nephropathy is the functional and /or parenchymal renal damage secondary to the urinary tract occlusion at any part of it. The inducing urinary obstruction diseases can vary depending on the patient´s age and gender. There are many renal dysfunction inducing mechanisms involved in this entity: increase in the intra-luminal pressure, ureteral dilatation with ineffective ureteral peristalsis, glomerular ultrafiltration net pressure reduction, intra-renal glomerular blood flux reduction due to vasoconstriction, and local disease of chemotactic substances. Obstructive nephropathy can also lead to hypertension (vasoconstriction-hypervolemia, hyperkalemia, metabolic acidosis (aldosterone resistance, diabetes insipidus (vasopressine resistance. In conclusion, since obstructive nephropathy is a potentially reversible cause of renal dysfunction, it should always be taken into account among the differential diagnosis of renal failure inducing mechanisms.

  9. Board Games Reconsidered: Mancala in the Balkans

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    Vesna Bikić

    2016-02-01

    Full Text Available Two mancala (one of the oldest games in the world boards, which were found in the Lower Town of the Belgrade Fortress in 2006, present so far unique archaeological proof that this game was played in the region of the Balkan peninsula. Considering the fact that the knowledge regarding mancala is still quite modest, in this paper, we have also examined the different aspects of this game: the question of its origin, which is linked to the beginning of the Neolithic Age on the territories of Africa and the Near East; the link with the methods of geomantic divination; the anthropological knowledge regarding playing mancala in traditional communities; the distribution and the directions of its diffusion, as well as the archaeological finds in the area Mediterranean.

  10. Results of kidney function measurement and blood pressure in population from endemic region of Vitina

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    Stašević Zvonimir

    2008-01-01

    Full Text Available Introduction. The analysis of frequency of kidney diseases, causes of terminal renal failure in patients subjected to repeated dialysis in major dialysis centers in the region of Kosovo and Metohija as well as mortality rate in these patients showed a stable number of patients with kidney diseases, evidencing that the populations of Vitina and Gnjilane were the most commonly affected. These towns are designated as regions with the highest incidence of Balkan endemic nephropathy. The present analysis was aimed at: 1. establishing the incidence rate of hypertension and renal function impairment by using clinical and laboratory analyses in individuals from Vitina and neighboring villages, and 2. investigating the correlation between creatinine clearance, age and arterial blood pressure in the studied group. Material and methods. The analysis included 510 individuals (excluding diabetics over the one-month period during 2004 (201 males with their age ranging from 18 to 90 years. Blood pressure measurements were performed in all the individuals, while renal function was determined by glomerular filtration rate (GFR, as calculated according to Cockcroft-Gault formula. Results. Creatinine clearance was lower than 100 ml/min in 237 (46.5% individuals, out of whom 62 (12% had GFR below 60 ml/min. Among the remaining 273 (53.5% individuals with GFR above 100 ml/min, 68 individuals had GFR above 140 ml/min. The distribution of patients depending on their systolic blood pressure values revealed that systolic blood pressure was lower in 44 subjects and higher in 302 subjects (59%. The correlation test revealed significant association between the studied parameters. The positive correlation between patients' age and kidney function means the higher the age of subjects the lower creatinine clearance value (r=-0.622, p<0.001. The negative correlation of the systolic blood pressure value and kidney function was found, meaning that higher the systolic blood

  11. Mouse Models of Diabetic Nephropathy

    OpenAIRE

    Brosius, Frank C.; Alpers, Charles E.; Bottinger, Erwin P.; Breyer, Matthew D.; Coffman, Thomas M.; Gurley, Susan B.; Harris, Raymond C.; Kakoki, Masao; Kretzler, Matthias; Leiter, Edward H.; Levi, Moshe; McIndoe, Richard A.; Sharma, Kumar; Smithies, Oliver; Susztak, Katalin

    2009-01-01

    Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Despite its prevalence, identification of specific factors that cause or predict diabetic nephropathy has been delayed in part by lack of reliable animal models that mimic the disease in humans. The Animal Models of Diabetic Complications Consortium (AMDCC) was created 8 years ago by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim rep...

  12. Marketing of the Balkans as à tourist destination for cultural tourism

    OpenAIRE

    2011-01-01

    The aim of this work is to outline possibilities for the marketing of the Balkans as à tourist destination for cultural tourism. It gives à definition of the Balkan region as à tourist destination. The target cultural tourist segments of the region are indicated. The strategic marketing mix is drawn for the positioning of the Balkans on the market of cultural tourism. The possible organizational platform for the marketing of the Balkans as à tourist destination is shown.

  13. Middle East: New Balkans of the World?

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Georgescu Stefan

    2012-12-01

    Full Text Available Middle East is a region whose geopolitical dynamics has many analogies with the role of the Balkans in the first half of the 19th century and up to the 3rd decade of the 20th century, namely a "Powder keg of Europe", defined in the same period as the "Eastern Issue".Moreover, Middle East is a region located at the junction of three continents: Europe, Asia and the Mediterranean Africa, and along with ancient Egypt is the cradle of Western civilization, providing for it political, economic, religious, scientific, military, intellectual and institutional models.Four millennia of civilization before Christian era did not pass without leaving a trace.Trade, currency, law, diplomacy, technology applied to works in time of war or peace, the profit based economy and the bureaucratized economy, popular and absolutist government, nationalist and universal spirit, tolerance and fanaticism – all these are not inventions of the modern world, but have their origins and methods of implementation, often even sophisticated methods, in this region.

  14. Banking Regulation Of Western Balkan Countries

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    Denada Hafizi

    2014-10-01

    Full Text Available The current global economic crisis has affected the development of banking system in Western Balkan Countries, including Italy and Greece. These effects are expressed with the contraction of lending, fallen of foreign direct investments, fallen of the volume of remittances and fallen of international trade. The banking system continually faces new challenges in a dynamically changing financial system, and this makes difficult theimplementation of bank regulation and supervision.All the countries have improved their banking regulation in order to avoid the contagion effect among banks and banking system in general, effects that get increased especially when banks are engaged in international banking. The standardization of regulatory requirements provides potential solution to the problems of regulating international banking. So, there is a moving through agreements like Basel Accords.For all these countries will be a comparison of regulatory capital to risk-weighted assets ratio and of capital to assets ratio in order to find out how well is capitalized their bankingsystem. The sources of data are the reports of International Monetary Fund for a time series of 2008-2013. In the end there are some conclusions for the main problems that theimplementation of supervision and bank regulation faces.Keywords: Basel Accords, Capital Ratio, Banking Regulation

  15. Anglophiles in Balkan Christian states (1862-1920

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    Markovich Slobodan G.

    2009-01-01

    Full Text Available The life stories of five Balkan Anglophiles emerging in the nineteenth century - two Serbs, Vladimir Jovanović (Yovanovich and Čedomilj Mijatović (Chedomille Mijatovich; two Greeks, Ioannes (John Gennadios and Eleutherios Venizelos; and one Bulgarian, Ivan Evstratiev Geshov - reflect, each in its own way, major episodes in relations between Britain and three Balkan Christian states (Serbia, the Hellenic Kingdom and Bulgaria between the 1860s and 1920. Their education, cultural patterns, relations and models inspired by Britain are looked at, showing that they acted as intermediaries between British culture and their own and played a part in the best and worst moments in the history of mutual relations, such as the Serbian-Ottoman crisis of 1862, the Anglo-Hellenic crisis following the Dilessi murders, Bulgarian atrocities and the Eastern Crisis, unification of Bulgaria and the Serbo-Bulgarian War of 1885, the Balkan Wars 1912-13, the National Schism in Greece. Their biographies are therefore essential for understanding Anglo-Balkan relations in the period under study. The roles of two British Balkanophiles (a Bulgarophile, James David Bourchier, and a Hellenophile, Ronald Burrows are looked at as well. In conclusion, a comparison of the Balkan Anglophiles is offered, and their Britain-inspired cultural and institutional legacy to their countries is shown in the form of a table.

  16. Light chain nephropathy

    Directory of Open Access Journals (Sweden)

    Sihem Darouich

    2015-01-01

    Full Text Available Light chain deposition disease (LCDD is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype. It is the archetypal systemic disease that is most frequently diagnosed on a kidney biopsy, although the deposits may involve several other organs. This brief review focuses on the clinicopathological features of LCDD-associated nephropathy with an emphasis on the diagnostic and therapeutic difficulties related to this elusive condition.

  17. Scorpion sting nephropathy

    OpenAIRE

    2011-01-01

    Scorpion envenomations are ubiquitous, but nephropathy is a rare manifestation, reported mainly from the Middle East and North Africa. Rapid venom redistribution from blood, delayed excretion from the kidneys, direct toxicity of venom enzymes, cytokine release and afferent arteriolar constriction have been seen in experimental animals. Haemoglobinuria, acute tubular necrosis, interstitial nephritis and haemolytic–uraemic syndrome have been documented in human victims of scorpion envenomation....

  18. Contrast-induced nephropathy

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    Ricardo A. García Hernández

    2016-06-01

    Full Text Available Contrast-induced nephropathy is an important complication associated with the use of contrast media. Favoring factors for the development of contrast-induced nephronpathy have been widely described, being diabetes mellitus and previous renal disease the greatest risk. The pathophysiology is a complex process where the medullary hypoxia represents the trigger element. Previous hydration and the use of low osmolality contrast are the most recommended measures to prevent its development.

  19. Social aspects of the transition to farming in the Balkans

    Directory of Open Access Journals (Sweden)

    Dušan Mihailović

    2007-12-01

    Full Text Available The Neolithization of the Balkans could be considered as a very complex social phenomenon. In this work we study the causes for the cultural and social integration of hunter-gatherer communities in the Late Glacial and Early Holocene, social networks and contacts in the Iron Gates Mesolithic, and also factors having an impact on the spread of the Neolithic in the Balkans. It has been perceived that the evolution of culture in the Balkans was simultaneously influenced by internal and external factors, and this contributed to the very rapid acceptance of Neolithic values and the Neo- lithic way of life in the period from 6500 to 6200 calBC.

  20. Native Dreissena freshwater mussels in the Balkans: in and out of ancient lakes

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    S. Trajanovski

    2010-10-01

    Full Text Available The Balkans is a biogeographically highly diverse region and a worldwide hotspot of endemic freshwater diversity. A substantial part of this diversity is attributed to well recognized and potential ancient lakes in its southwestern part. However, despite considerable research efforts, faunal relationships among those lakes are not well understood. Therefore, genetic information from native representatives of the mussel genus Dreissena is here used to test the biogeographical zonation of the southwestern Balkans, to relate demographic changes to environmental changes, to assess the degree of eco-insularity, to reconstruct their evolutionary history, and to explore the potential of native taxa for becoming invasive. Phylogeographical and population genetic analyses indicate that most studied populations belong to two native species: D. presbensis (including the distinct genetic subgroup from Lake Ohrid, "D. stankovici" and D. blanci. In addition, the first confirmed record of invasive D. polymorpha in the southwestern Balkan is presented. The distribution of native Dreissena spp. generally coincides with the biogeographical zonations previously suggested based on fish data. However, there is disagreement on the assignment of the ancient lakes in the area to respective biogeographical regions. The data for Lake Ohrid are not conclusive. A closer biogeographical connection to lakes of the Vardar region and possibly the northern Ionian region is, however, suggested for Lake Prespa. The reconstruction of the evolutionary history of Dreissena spp. suggests that populations underwent demographic and spatial expansions in the recent past. Expansions started around 320 000–300 000 years ago in "D. stankovici", 160 000–140 000 years ago in D. blanci, and 110 000–70 000 years ago in D. presbensis. These time frames are discussed within the context of available paleogeological data for lakes Ohrid and Prespa. It is suggested that regional environmental

  1. Post-Structuralism and Politics: towards Postmodern Balkan Studies

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    Sanja LAZAREVIC RADAK

    2015-12-01

    Full Text Available Although post-structuralism, on the first sight, lacks political dimension, its application to social problems expose the potential of political engagement. First, it comes from interviving linguistics and humanities, that inspired new understanding of the relationship between structure and power. While emerging from cultural studies and therefore from synthesis of history and literary criticism, studies on the Balkan, point out a role of mental images, stereotypes, discourses and therefore, political power of its image. Following the concepts of Michel Foucault, Jacques Lacan, Jacques Derrida and to lesser extent Julia Kristeva, the Balkans is set within the post-structural paradigm.

  2. On some neglected balkanisms in the Serbian verbal systems

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    Topolińska Zuzanna

    2008-01-01

    Full Text Available The author finds that one of the most prominent features of the so-called Balkan Sprachbund is the extended system of grammaticalized modal distinctions both in the episthemic and deontic functional zone. She then focuses on two tendencies characteristic of the Balkan Sprachbund which are also present in the Serbian verbal system: (1 the differentiation of the exponents of the predicate of negation depending on its function and position in the discourse, and (2 the tendency to transform the synsemantic, most often modal, verbs into indeclinable particles.

  3. Diabetic nephropathy : pathology, genetics and carnosine metabolism

    NARCIS (Netherlands)

    Mooyaart, Antien Leonora

    2011-01-01

    My thesis concerns different aspects of diabetic nephropathy. A pathologic classification of diabetic nephropathy is developed, a meta-analyis of genes in diabetic nephropathy is developed and the other chapters are about the CNDP1 gene in relation to kidney disease, mainly diabetic nephropathy.

  4. [Classification of Diabetic Nephropathy 2014].

    Science.gov (United States)

    Haneda, Masakazu; Utsunomiya, Kazunori; Koya, Daisuke; Babazono, Tetsuya; Moriya, Tatsumi; Makino, Hirofumi; Kimura, Kenjiro; Suzuki, Yoshiki; Wada, Takashi; Ogawa, Susumu; Inaba, Masaaki; Kanno, Yoshihiko; Shigematsu, Takashi; Masakane, Ikuto; Tsuchiya, Ken; Honda, Keiko; Ichikawa, Kazuko; Shide, Kenichiro

    2014-01-01

    The Committee on Diabetic Nephropathy revised the classification of diabetic nephropathy in view of the current status of eGFR and CKD in Japan. To make revisions for the classification of diabetic nephropathy 2014, the Committee carefully evaluated the report of the Research Group on Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. The major revisions made were as follows: 1. eGFR can be used for the evaluation of GFR; 2. In stage 3 (overt nephropathy), A and B were combined; 3. Stage 4 (renal failure) was defined as GFR less than 30 mL/min/1.73 m2, regardless of albuminuria; and 4. The importance of differential diagnosis was stressed in all stages.

  5. „Pseudo-yat“ in Dalmato-Romance and Balkan Latin (On Balkan Latin VIII

    Directory of Open Access Journals (Sweden)

    Ligorio Orsat L.

    2015-01-01

    Full Text Available Article discusses the origins and the development of the so-called pseudo-yat in Dalmatian Romance and Balkan Latin. (E.g. SCr. mrčela-murtila-murtela from Lat. *MYRTICELLA or tovijerna-tovirna-toverna from TABERNA. Pseudo-yat is derived from -ECC-, in short syllables, and in long syllables from -ERR-, -ERC-. This suggestion is tried on 58 Dalmatian loans in Serbo-Croatian. The fact that pseudo-yat is found only in a part of these is of particular significance for the stratification of Dalmatian loans in Serbo-Croatian since loans with pseudo-yat are ostensibly older than the ones without it. [Projekat Ministarstva nauke Republike Srbije, br. 178007

  6. Contrast induced nephropathy

    DEFF Research Database (Denmark)

    Stacul, Fulvio; van der Molen, Aart J; Reimer, Peter

    2011-01-01

    measures used to reduce the incidence of CIN, and the management of patients receiving metformin. Key Points • Definition, risk factors and prevention of contrast medium induced nephropathy are reviewed. • CIN risk is lower with intravenous than intra-arterial iodinated contrast medium. • eGFR of 45 ml....../min/1.73 m (2) is CIN risk threshold for intravenous contrast medium. • Hydration with either saline or sodium bicarbonate reduces CIN incidence. • Patients with eGFR ≥ 60 ml/min/1.73 m (2) receiving contrast medium can continue metformin normally....

  7. Contrast induced nephropathy

    DEFF Research Database (Denmark)

    Stacul, Fulvio; van der Molen, Aart J; Reimer, Peter

    2011-01-01

    measures used to reduce the incidence of CIN, and the management of patients receiving metformin. Key Points • Definition, risk factors and prevention of contrast medium induced nephropathy are reviewed. • CIN risk is lower with intravenous than intra-arterial iodinated contrast medium. • eGFR of 45 ml....../min/1.73 m (2) is CIN risk threshold for intravenous contrast medium. • Hydration with either saline or sodium bicarbonate reduces CIN incidence. • Patients with eGFR = 60 ml/min/1.73 m (2) receiving contrast medium can continue metformin normally....

  8. Heroin crystal nephropathy.

    Science.gov (United States)

    Bautista, Josef Edrik Keith; Merhi, Basma; Gregory, Oliver; Hu, Susie; Henriksen, Kammi; Gohh, Reginald

    2015-06-01

    In this paper we present an interesting case of acute kidney injury and severe metabolic alkalosis in a patient with a history of heavy heroin abuse. Urine microscopy showed numerous broomstick-like crystals. These crystals are also identified in light and electron microscopy. We hypothesize that heroin crystalizes in an alkaline pH, resulting in tubular obstruction and acute kidney injury. Management is mainly supportive as there is no known specific therapy for this condition. This paper highlights the utility of urine microscopy in diagnosing the etiology of acute kidney injury and proposes a novel disease called heroin crystal nephropathy.

  9. Motives underlying food consumption in the Western Balkans

    NARCIS (Netherlands)

    Mardon, Julie; Thiel, Elise; Laniau, Martine; Sijtsema, Siet; Zimmermann, Karin; Barjolle, Dominique

    2015-01-01

    Objectives: This study aims to identify subgroups of consumers based on the health motives underlying their food choice in Western Balkan Countries. Methods: The survey (n = 2943) was based on the Food Choice Questionnaire (FCQ) and elicited information on socio-demographic characteristics, consu

  10. The Balkans: Between Economic Crisis And European Integration

    Directory of Open Access Journals (Sweden)

    Andrei RĂDULESCU

    2012-06-01

    Full Text Available The Balkans region (also known as the „Powder keg of Europe” has always been an European question, a Western question, as underlined by Arnold Toynbee, in 1922. At present, European Union is confronted with the fifth enlargement, also known as the “post-conflict” enlargement – the integration of Balkan states. Bulgaria joined European Union in 2007. Croatia signed the Accession Treaty in 2011 and is expected to become an EU member in 2013. The other countries encounter in different stages of European integration. However, this process presents several challenges and dilemmas, either for European Union, or for the Balkan enclave. The main challenge in the case of this enlargement is to reconcile the nation-state building and the European integration. From the economic point of view, the Balkans region is underdeveloped. Several factors determined this stance of the region: the poor endowment in terms of natural resources, the political situation over the centuries (the military conflicts – impeding the economic development, the cultural factors. At present, the region is confronted with the consequences of the worst economic and financial crisis o global economy since the end of World War II.

  11. Mafia links between the Balkans and Scandinavia. State of affairs

    Directory of Open Access Journals (Sweden)

    Matteo Albertini

    2012-11-01

    Full Text Available The last twenty years has seen an increasing presence of Balkan organized crime groups in security reports and newspapers' headlines. This does not mean that mafia groups did not exist during Socialist Yugoslavia – even if its collapse and the following war made criminals and smugglers useful for politicians and leaders to maintain their power; it rather means that Balkan organized crime came outside its traditional areas of action in Serbia, Montenegro and Albania: less territorial and nationalist than it was before, it is now gaining prominence in an international scenario, making agreements with Italian and South American mafias – the so-called Holy Alliance – to manage drug routes towards Western Europe. One of the most interesting factors concerning Balkan mafia groups today is their presence in countries which traditionally do not have a history of organized crime, such as the Scandinavian states. One of the reasons lies in the wide percentage of immigrants moving from Balkan countries to Sweden or Norway. Since the wars of the 1990s in the former Yugoslavia, war-crimes fugitives were able to become common criminals in these countries, such as the infamous Želiko Raznjatović (“Arkan”. However, year by year, these gangs grew larger, taking advantage of the “expertise” and the resources gained during the war. In particular, the most spectacular case – the Våstberga helicopter robbery in 2009 – showed how these groups operate with military-style precision, utilize a wide number of participants, and have at their disposal laerge amounts of weapons and money. This paper will draw on the importance of Scandinavian – Balkan mafia relations in relation to three main criminal areas: drug and weapon smuggling and human trafficking, in order to underline the role of diasporas in enforcing organized crime groups and the extent to which these mafias could be a threat for the stability in both Eastern and Western Europe.

  12. The Balkans and Syria’s Civil War: Realities and Challenges

    Directory of Open Access Journals (Sweden)

    MA. Perparim Gutaj

    2014-06-01

    Full Text Available The prime objective of this research paper is to look at the realities and challenges confronting the Balkan states and societies in light of Syria’s civil war. By examining the mobilization process of Balkan militants who are joining Syria’s rebel cause, especially the Islamic radical groups linked to al-Qaeda, this paper proposes a model that explains why and how Balkan militants are joining the fight in Syria. Drawing upon reliable media reports, personal observations, academic accounts, and other consistent sources, this paper argues that Balkan militants are joining Syria’s rebel cause because foreign Islamic radical groups (that have been operating in the Balkans since the early 1990s have successfully indoctrinated them. This paper challenges the argument that Islam in the Balkans is a threat to the region, and the claim that Balkan Islam and Muslims in the region are becoming an increasing threat to the West. The central findings of this paper exemplify that the future of Balkan militants is bleak and that they will be confronted with a massive modern and democratic resistance that offers them nothing but reintegration into Balkan Islam, their natural “religious nest.” Notwithstanding the trends related to Syria’s civil war, Balkan Muslims belong to the West, culturally and mentally.

  13. Ochratoxin A levels in human serum and foods from nephropathy patients in Tunisia: where are you now?

    Science.gov (United States)

    Hmaissia Khlifa, K; Ghali, R; Mazigh, C; Aouni, Z; Machgoul, S; Hedhili, A

    2012-07-01

    Ochratoxin A is a natural mycotoxin with nephrotoxic properties that can contaminate food products. It has been detected in high amount in human serum collected from nephropathy patients, especially those categorized as having a chronic interstitial nephropathy of unknown etiology. In the present study, ochratoxin A levels were measured in commonly consumed food items and in serum samples from nephropathy and healthy subjects in Tunisia. To assess ochratoxin A, a high performance liquid chromatography method was optimized. The ochratoxin A assay showed very different scales of ochratoxin A serum and food contamination from 0.12 to 1.5 ng/mL and 0.11 to 6.1 ng/g respectively, and in healthy subjects and 0.11 to 33.8 ng/g for food and 0.12 to 3.8 ng/mL for serum in nephropathy patients suffering from chronic interstitial nephropathy of unknown etiology. The disease seems related to ochratoxin A serum levels and food contaminations, since the healthy group was significantly different from the nephropathy group (Pochratoxin A contamination. Those results combined with data published already, emphasize the likely endemic aspect of ochratoxin A-related nephropathy occurring in Tunisia.

  14. ANTIOXIDANT STATUS IN DIABETIC NEPHROPATHY

    Directory of Open Access Journals (Sweden)

    Giriraja

    2015-12-01

    Full Text Available BACKGROUND Hyperglycemia and dislipidemia in DM induce increased lipid peroxdation and free radical formation. This is an important mechanism of microangiopathy. AIM To measure the antioxidant status in type 2 DM with nephropathy and compared with nondiabetic control group. MATERIALS AND METHODS 50 type 2 DM patients aged between 50 to 70 years according to national diabetes data group criteria with nephropathy diagnosed on the basis of history, physical examination and biochemical parameters were included. 50 age and sex matched apparently healthy individuals with normal plasma glucose, normal renal parameters and with no symptoms suggestive of DM were taken as controls. RESULTS Antioxidant status was significantly less in patients with diabetic nephropathy. CONCLUSION Data suggests that alteration in antioxidant status may help predict the risk of diabetic nephropathy.

  15. GENETICS ASPECTS OF DIABETIC NEPHROPATHY

    Directory of Open Access Journals (Sweden)

    Oana-Elena Sauca

    2010-09-01

    Full Text Available Diabetic nephropathy is a clinical syndrome characterized by persistent albuminuria, a relentless decline in GFR, raised arterial blood pressure, and increased relative mortality for cardiovascular diseases. The pathogenesis of diabetic nephropathy is multifactorial, with contributions from metabolic abnormalities, hemodynamic alteration, and various growth and genetic factors. The identification of the main genes would allow the detection of those individuals at high risk for diabetic nephropathy and better understanding of its pathophysiologyas well.The present review discusses the main information available in literature regarding some genetic variants (involved in the renin-angiotensin system, glucose and lipid metabolism and some cytoskeleton proteins that reaffirms the importance of genetic factors in diabetic nephropathy.

  16. Diabetic Nephropathy without Diabetes

    Directory of Open Access Journals (Sweden)

    Katia López-Revuelta

    2015-07-01

    Full Text Available Diabetic nephropathy without diabetes (DNND, previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features.

  17. How unique is the tiger beetle fauna (Coleoptera, Cicindelidae of the Balkan Peninsula?

    Directory of Open Access Journals (Sweden)

    Radomir Jaskula

    2011-05-01

    Full Text Available The tiger beetle fauna of the Balkan Peninsula is one of the richest in Europe and includes 19 species or 41% of the European tiger beetle fauna. Assembled by their biogeographical origins, the Balkan tiger beetle species fall into 14 different groups that include, Mediterranean, Middle Oriental, Central Asiatic, Euro-Siberian, South and East European, Pannonian-Sarmatian, West Palaearctic, Turano-European and Afrotropico Indo-Mediterranean species. The Mediterranean Sclerophyl and the Pontian Steppe are the Balkan biogeographical provinces with the highest species richness, while the Balkan Highlands has the lowest Cicindelidae diversity. Most species are restricted to single habitat types in lowland areas of the Balkan Peninsula and only Calomera aulica aulica and Calomera littoralis nemoralis occur in respectively 3 and 4 different types of habitat. About 60% of all Balkan Cicindelidae species are found in habitats potentially endangered by human activity.

  18. Genetic Diversity and Conservation of the Prespa Trout in the Balkans

    Directory of Open Access Journals (Sweden)

    Patrick Berrebi

    2013-11-01

    Full Text Available The Balkans are known to have a high level of biodiversity and endemism. No less than 15 taxa have been recorded in salmonids of the Salmo genus. Among them, the Prespa trout is found in only four river systems flowing into Lake Macro Prespa, three in the Former Yugoslav Republic of Macedonia and one in Greece. This is the first comprehensive survey of all streams located within the Macro Prespa Basin, encompassing the whole taxon range. A large genetic sample of 536 Prespa trout was collected mainly between 2005 and 2007. The sampling included 59 individuals from the Golema river system, 93 from the Kranska, 260 from the Brajcinska, 119 from the Agios Germanos, and five individuals from the lake itself. These specimens were analyzed with six microsatellite markers and by sequencing the mitochondrial control region. Nuclear data were examined through multidimensional analysis and assignment tests. Five clusters were detected by assignment: Golema, Kranska, Brajcinska upstream, Rzanska Brajcinska tributary and Brajcinska downstream. Most of these river systems thus hosted differentiated Prespa trout populations (with past gene flows likely dating before the construction of dams, except Agios Germanos, which was found to be composed of 5% to 32% of each cluster. Among the five trout individuals from the lake, four originated from Kranska River and one was admixed. Supported parsimonious hypotheses are proposed to explain these specificities. Conservation of this endemic taxon should take these results into account. No translocation should be performed between different tributaries of the lake and preservation of the Brajcinska populations should address the upstream-downstream differentiation described.

  19. Neglected and endemic zoonoses

    OpenAIRE

    2009-01-01

    Endemic zoonoses are found throughout the developing world, wherever people live in close proximity to their animals, affecting not only the health of poor people but often also their livelihoods through the health of their livestock. Unlike newly emerging zoonoses that attract the attention of the developed world, these endemic zoonoses are by comparison neglected. This is, in part, a consequence of under-reporting, resulting in underestimation of their global burden, which in turn artificia...

  20. INTERNET ADDICTION IN BALKAN AND SOUTH-EASTERN EUROPEAN COUNTRIES

    Directory of Open Access Journals (Sweden)

    Ioannis PETASAKIS

    2012-12-01

    Full Text Available The use of Internet has increased dramatically in recent years. Although there is no standardized definition of Internet addiction, there is acknowledgement among researchers that this phenomenon does exist. In this study, we identify various similarities and differences among people in the Balkan and South-Eastern European countries about Internet addiction. There are many factors such as cultural differences, gender differences, psychosocial variables, computer attitudes and time.We present the experience from studies concerning Internet addiction in all over the world. A specific research with the use of Young's 20-scale was also conducted in five Balkan and South-Eastern European countries (Republic of Moldova, Romania, Republic of Bulgaria, Hellenic Republic, Republic of Cyprus.The findings are interesting. Although there is a need for Interest using, there are also cases where the addiction, dependence and abuse is apparent.

  1. From Boston to the Balkans: Olmsted’s Emerald Legacy

    Directory of Open Access Journals (Sweden)

    Christina Luke

    2013-01-01

    Full Text Available This article explores the legacy of landscape architect Fredrick Law Olmsted on modern cultural tourism policies. The author explains the involvement of Olmsted in the founding of Yosemite National Park, and describes the influence of this experience on his later work on the Emerald Necklace parks project in Boston. This became a model for natural and cultural corridors worldwide, including those in the Balkans and Turkey.

  2. Cultural Identity and Regional Security in the Western Balkans

    Science.gov (United States)

    2013-06-13

    in the culture, and a means of spiritual survival and resistance to assimilation.”39 This epic poetry “ensured the continuation of collective memory ...historical traditions and epic poetry became the only integrating factor for the Serbian people, the most important elements of the communication system...Outcomes of the Second World War in the Western Balkans were spoiled ethnic relations, hatred, and fear that would remain in national memory until

  3. Visual material evidence of viking presence in the Balkans

    Directory of Open Access Journals (Sweden)

    Konstantin Kolev Jr

    2015-06-01

    Full Text Available The Swedish and Norwegian Vikings were present in the Balkans including in Bulgaria. The archaeological and visual materials found on the Romanian, Bulgarian and Turkish territory support this statement. The majority of the objects constitute parts of weapons and tools related to the Scandinavian warfare. Most of these artifacts were discovered in North East of Bulgaria close to the Romanian border. They can be attributed to the Rus princes (father and son: Igor I (912-945 and Svyatoslav I Igorevich (942-972 who passed by the Bulgarian lands in the 10-th century and the Norwegian prince Harald who supported the Byzantine Empire to cause the downfall of the First Bulgarian kingdom at the beginning of the next century. Despite this sorrowful reputation, though, the Viking material culture in Bulgaria, Romania and Istanbul gives evidence to the multicultural mosaic of our region. It also enriches the Balkan history and culture. Therefore, the purpose of this article is to outline the Viking objects discovered in the Balkans.

  4. Surveillance of wildlife zoonotic diseases in the Balkans Region

    Directory of Open Access Journals (Sweden)

    Mirsada Hukić

    2010-08-01

    Full Text Available The countries of the Balkan Peninsula have become the region with frequent outbreaks of the emerging and re-emerging diseases during the last decade of the 20th and the first decade of the 21st century. The majority of outbreaks were wildlife zoonotic, and vector-borne diseases, such as brucellosis, leptospirosis, listeriosis, tularemia, Q-fever, Lyme disease, anthrax, rabies, viralhemorrhagic fevers, sandfly fever, tick-borne encephalitis and leishmainiasis. Epidemiological factors determined by ecology ofcausative agents are often the most useful diagnostic clues. The recognition of evolving problems of emerging and re-emergingdiseases emphasizes the need for the development of better laboratory diagnostic methods for the surveillance and tracking ofthe diseases, and for continued research of factors contributing to the transmission of the organisms. The continuous occurrence of previously unidentified infections requires prospective nationalstrategies for timely recognition of the syndromes, causative agent identification, establishment of criteria and methods for the diagnosis, optimization of the treatment regime, and determinationof successful approaches to prevention and control. Wildlife diseasessurveillance in the most of the Balkan countries has been coordinated by the WHO since 1992. Although new technology and communication have extremely improved in the last decade, there is a need for optimal communication lines among the Balkan countries, better exploitation of communication technologies like the Internet and other media in the field of emerging diseases.

  5. Surveillance of wildlife zoonotic diseases in the Balkans Region.

    Science.gov (United States)

    Hukić, Mirsada; Numanović, Fatima; Sisirak, Maida; Moro, Almedina; Dervović, Edina; Jakovec, Sanja; Besić, Irma Salimović

    2010-08-01

    The countries of the Balkan Peninsula have become the region with frequent outbreaks of the emerging and re-emerging diseases during the last decade of the 20th and the first decade of the 21st century. The majority of outbreaks were wildlife zoonotic, and vector-borne diseases, such as brucellosis, leptospirosis, listeriosis, tularemia, Q-fever, Lyme disease, anthrax, rabies, viral hemorrhagic fevers, sandfly fever, tick-borne encephalitis and leishmainiasis. Epidemiological factors determined by ecology of causative agents are often the most useful diagnostic clues. The recognition of evolving problems of emerging and re-emerging diseases emphasizes the need for the development of better laboratory diagnostic methods for the surveillance and tracking of the diseases, and for continued research of factors contributing to the transmission of the organisms. The continuous occurrence of previously unidentified infections requires prospective national strategies for timely recognition of the syndromes, causative agent identification, establishment of criteria and methods for the diagnosis, optimization of the treatment regime, and determination of successful approaches to prevention and control. Wildlife diseases surveillance in the most of the Balkan countries has been coordinated by the WHO since 1992. Although new technology and communication have extremely improved in the last decade, there is a need for optimal communication lines among the Balkan countries, better exploitation of communication technologies like the Internet and other media in the field of emerging diseases.

  6. THE EUROPEAN UNION AND THE BALKANS: BETWEEN SYMBIOSIS AND INTEGRATION?

    Directory of Open Access Journals (Sweden)

    Kyriakos D. Kentrotis

    2010-09-01

    Full Text Available The European Union continues to constitute an incomplete economic-political entity at intergovernmental and supranational level. The EU is seeking to establish appropriate functional superstructures extending beyond the narrow confines of trade, the economy and free market rules to accommodate its integral progress as a new force for prosperity, democracy and peace in the world. On the map of the Balkans, the local political actors continue to define their choices in line with their historic experience and stereotypes, especially as regards their neighbours and the Great Powers of the moment. The Balkan countries, which in any case are still seeking to consolidate their conventional state structures, need much more time to find their place within this unfinished supranational European structure. In both cases the actors involved, whether in the EU or in the Balkans, are grappling with the challenges of global politics from their different starting-points, but it is not easy to overcome the boundaries of their national sovereignty.

  7. Fossil nickel laterite deposits of the Balkan region; Fossile Nickellaterit-Lagerstaetten auf dem Balkan

    Energy Technology Data Exchange (ETDEWEB)

    Masurenko, Christian [European Nickel PLC, London (United Kingdom); Radosevic, Branislav [Advanced Systems, Belgrade (RS)

    2008-11-15

    Acid heap leaching is common in the gold and copper industry with the majority of new copper projects being heap leaching (cyanide leaching). Although nickel is worth two to three times more than copper, the process had not been used extensively on nickel ores. The geological formation that led to the Caldag nickel deposit lends itself to heap leaching due to the low clay content of the ore. The nickel is present in the goethitic phase and is soluble in diluted sulphuric acid. The lack of clays in the laterite profile assists the percolation of the solutions through the heaps throughout the heap leach cycle, which in Caldag's case is well over a year. European Nickel has demonstrated the percolation and extraction of nickel at a large scale pilot plant continuously over a three year period, irrigating the heaps with dilute sulphuric acid and producing saleable mixed hydroxide product from the downstream precipitation plant. Compared with pyrometallurgical processes ENickel's process is environment benign and easier to control. The process does not lead to any emissions. The production of sulphuric acid even provides electricity in excess which will be, in the case of Caldag, fed into the local grid. Today, also low grade deposits such as the nickel laterite deposits of the Balkan, often with grades lower than 1.0 % Ni, become more and more interesting. ENickel has recently completed a preliminary economic assessment of the Devolli deposit in Albania. Initial results show a capital investment of approx. 369 Mio. Euro and development of more than 700 direct jobs. The capital investment is therefore five to six times smaller than compared with any pyrometallurgical process (> 2 bn Euro). During the last years ENickel tested different ore types from various deposits all over the world (e.g. Kazakhstan, Philippines, India). One can distinguish two different types of laterites. Recent laterites which occur in the tropical regions of Australia, Indonesia and the

  8. The Balkan Theme in The Secret of Chimneys

    Directory of Open Access Journals (Sweden)

    Graham St. John Stott

    2016-06-01

    Full Text Available In The Secret of Chimneys (1925 Agatha Christie uses the all too familiar Balkan stereotypes of backwardness and brigandage, but not – as was usually the case at the time – as an Other to illustrate British virtue, but as a mirror to British vice. It is Britain, not the fictional Herzoslovakia, that is a nation of brigands. Herzoslovakia remains relatively unknown, as none of the novel’s scenes take place there, but it is described by disinterested observers as democratic and prosperous. In London, however, the Foreign Office plans to overthrow its government to secure oil rights promised by a royal heir-in-exile to a London-based financial consortium. Keywords: Christie, Balkans, Romania, oil, brigandsAgatha Christie’s The Secret of Chimneys (1925 has been faulted for being on the one hand a frothy mix of Anthony Hope and P. G. Wodehouse (Thompson 143 and on the other a mishmash of popular ethnic, national and regional stereotypes – including those of the Balkans (Todorova 122. It is, however, a far more subtle work than such accounts suggest. Though the influence of Hope and Wodehouse can certainly be seen in the novel’s story of princes in disguise (reminiscent of The Prisoner of Zenda and a country house setting that would have reminded readers of Blandings, its main plot addresses an important theme –and in exploring it Christie takes the Balkans very seriously. Oil has been found in the Republic of Herzoslovakia and the Foreign Office, represented by George Lomax, has secured the pledge of the exiled Prince Michael Obolovitch “to grant certain oil concessions” to a consortium led by Herman Isaacstein if the Obolovitchs are restored to power. In other words: to secure those concessions the British Government has committed itself to the overthrow of Herzoslovakia’s government. The Foreign Office’s interest in the Balkans might not have surprised Christie’s readers. The Anglo-Iranian Oil Company had held a monopoly on

  9. [Novel biomarkers for diabetic nephropathy].

    Science.gov (United States)

    Araki, Shin-ichi

    2014-02-01

    Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. An early clinical sign of this complication is an increase of urinary albumin excretion, called microalbuminuria, which is not only a predictor of the progression of nephropathy, but also an independent risk factor for cardiovascular disease. Although microalbuminuria is clinically important to assess the prognosis of diabetic patients, it may be insufficient as an early and specific biomarker of diabetic nephropathy because of a large day-to-day variation and lack of a good correlation of microalbuminuria with renal dysfunction and pathohistological changes. Thus, more sensitive and specific biomarkers are needed to improve the diagnostic capability of identifying patients at high risk. The factors involved in renal tubulo-interstitial damage, the production and degradation of extracellular matrix, microinflammation, etc., are investigated as candidate molecules. Despite numerous efforts so far, the assessment of these biomarkers is still a subject of ongoing investigations. Recently, a variety of omics and quantitative techniques in systems biology are rapidly emerging in the field of biomarker discovery, including proteomics, transcriptomics, and metabolomics, and they have been applied to search for novel putative biomarkers of diabetic nephropathy. Novel biomarkers or their combination with microalbuminuria provide a better diagnostic accuracy than microalbuminuria alone, and may be useful for establishing personal medicine. Furthermore, the identification of novel biomarkers may provide insight into the mechanisms underlying diabetic nephropathy.

  10. Neglected and endemic zoonoses.

    Science.gov (United States)

    Maudlin, Ian; Eisler, Mark Charles; Welburn, Susan Christina

    2009-09-27

    Endemic zoonoses are found throughout the developing world, wherever people live in close proximity to their animals, affecting not only the health of poor people but often also their livelihoods through the health of their livestock. Unlike newly emerging zoonoses that attract the attention of the developed world, these endemic zoonoses are by comparison neglected. This is, in part, a consequence of under-reporting, resulting in underestimation of their global burden, which in turn artificially downgrades their importance in the eyes of administrators and funding agencies. The development of cheap and effective vaccines is no guarantee that these endemic diseases will be eliminated in the near future. However, simply increasing awareness about their causes and how they may be prevented-often with very simple technologies-could reduce the incidence of many endemic zoonoses. Sustainable control of zoonoses is reliant on surveillance, but, as with other public-sector animal health services, this is rarely implemented in the developing world, not least because of the lack of sufficiently cheap diagnostics. Public-private partnerships have already provided advocacy for human disease control and could be equally effective in addressing endemic zoonoses.

  11. Non-Proteinuric Diabetic Nephropathy

    Science.gov (United States)

    Robles, Nicolas Roberto; Villa, Juan; Hernandez Gallego, Roman

    2015-01-01

    Diabetic nephropathy patients traditionally show significant macroalbuminuria prior to the development of renal impairment. However, this clinical paradigm has recently been questioned. Epidemiological surveys confirm that chronic kidney disease (CKD) diagnosed by a low glomerular filtration rate (GFR) is more common in diabetic patients than in the non-diabetic population but a low number of patients had levels of proteinuria above that which traditionally defines overt diabetic nephropathy (>500 mg/g). The large number of patients with low levels of proteinuria suggests that the traditional clinical paradigm of overt diabetic nephropathy is changing since it does not seem to be the underlying renal lesion in most of diabetic subjects with CKD. PMID:26371050

  12. Helianthemum marmoreum (Cistaceae), a new species from the Central Balkans

    DEFF Research Database (Denmark)

    Stevanovic, Vladimir; Matevski, Vlado; Tan, Kit

    2009-01-01

    Helianthemum marmoreum is described as a new species from the central part of the Balkan peninsula is described as a new species from the central part of the Balkan peninsula (R. Macedonia). It inhabits rocky marble and limestone slopes and pastures at moderate altitudes of 240-1400 m. The closes...

  13. International Trends in Health Science Librarianship Part 19: The Balkan States (Bulgaria and Croatia).

    Science.gov (United States)

    Kirilova, Savina; Skoric, Lea

    2016-09-01

    This is the 19th in a series of articles exploring international trends in health science librarianship in the 21st century. The focus of the present issue is the Balkan Region (Bulgaria and Croatia). The next regular feature column will investigate two other Balkan states - Serbia and Slovenia. JM.

  14. Interstitial nephritis and interstital nephropathy

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930154 Plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in diabetic nephropathyWANG Yao(王尧),et al,Dept Endocrinol,1stAffil Hosp,Nanjihng Railway Med Coll.210009.Chin J Nephrol 1992;8(5):275-277.The plasma levels of TXB2 and 6-keto-PGF1were measured by RIA in 14 diabetics with and49 diabetics without nephropathy and 35 normalsubjects.The results showed that the levels ofplasma TXB2 and the ratio of TXB2/6-keto-PGF.were increased both in diabetics with or

  15. Lost in scales: Balkan folk music research and the ottoman legacy

    Directory of Open Access Journals (Sweden)

    Pennanen Risto Pekka

    2008-01-01

    Full Text Available Balkan folk music researchers have articulated various views on what they have considered Oriental or Turkish musical legacy. The discourses the article analyses are nationalism, Orientalism, Occidentalism and Balkanism. Scholars have handled the awkward Ottoman issue in several manners: They have represented 'Oriental' musical characteristics as domestic, claimed that Ottoman Turks merely imitated Arab and Persian culture, and viewed Indian classical raga scales as sources for Oriental scales in the Balkans. In addition, some scholars have viewed the 'Oriental' characteristics as stemming from ancient Greece. The treatment of the Segâh family of Ottoman makams in theories and analyses reveals several features of folk music research in the Balkans, the most important of which are the use of Western concepts and the exclusive dependence on printed sources. The strategies for handling the Orient within have meandered between Occidentalism and Orientalism, creating an ambiguity which is called Balkanism.

  16. Podocyte Pathology and Nephropathy

    Directory of Open Access Journals (Sweden)

    Sandra eMerscher

    2014-07-01

    Full Text Available Sphingolipids are components of the lipid rafts in plasma membranes, which are important for proper function of podocytes, a key element of the glomerular filtration barrier. Research revealed an essential role of sphingolipids and sphingolipid metabolites in glomerular disorders of genetic and non-genetic origin. The discovery that glucocerebrosides accumulate in Gaucher disease in glomerular cells and are associated with clinical proteinuria initiated intensive research into the function of other sphingolipids in glomerular disorders. The accumulation of sphingolipids in other genetic diseases including Tay-Sachs, Sandhoff, Fabry, hereditary inclusion body myopathy 2, Niemann-Pick and nephrotic syndrome of the Finnish type and its implications with respect to glomerular pathology will be discussed. Similarily, sphingolipid accumulation occurs in glomerular diseases of non-genetic origin including diabetic kidney disease (DKD, HIV-associated nephropathy, focal segmental glomerulosclerosis (FSGS and lupus nephritis. Sphingomyelin metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate have also gained tremendous interest. We recently described that sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b is expressed in podocytes where it modulates acid sphingomyelinase (ASMase activity and acts as a master modulator of danger signaling. Decreased SMPDL3b expression in post-reperfusion kidney biopsies from transplant recipients with idiopathic FSGS correlates with the recurrence of proteinuria in patients and in experimental models of xenotransplantation. Increased SMPDL3b expression is associated with DKD. The consequences of differential SMPDL3b expression in podocytes in these diseases with respect to their pathogenesis will be discussed. Finally, the role of sphingolipids in the formation of lipid rafts in podocytes and their contribution to the maintenance of a functional slit diaphragm in the glomerulus will be discussed.

  17. Tephrostratigraphy and tephrochronology of lakes Ohrid and Prespa, Balkans

    Science.gov (United States)

    Sulpizio, R.; Zanchetta, G.; D'Orazio, M.; Vogel, H.; Wagner, B.

    2010-10-01

    Four cores from Balkans lakes Ohrid and Prespa were examined for recognition of tephra layers and cryptotephras, and the results presented along with the review of data from other two already published cores from Lake Ohrid. The six cores provide a previously unrealised tephrostratigraphic framework of the two lakes, and provide a new tephrostratigraphic profile (composite) for the Balkans, which spans from the end of the Middle Pleistocene to the AD 472. A total of 12 tephra layers and cryptotephras were recognised in the cores. One is of Middle Pleistocene age (131 ka) and correlated to the marine tephra layer P-11 from Pantelleria Island. Eight volcanic layers are Upper Pleistocene in age, and encompass the period between ca. 107 ka and ca. 31 ka. This interval contains some of the main regional volcanic markers of the central Mediterranean area, including X-6, X-5, Y-5 and Y-3 tephra layers. The other layers of this interval have been related to the marine tephra layers C20, Y-6 and C10, while one was for the first time recognised in distal areas and correlated to the Taurano eruption of probable Vesuvian origin. Three cryptotephras were of Holocene age. Two of which have been correlated to Mercato and AD 472 eruptions of Somma-Vesuvius, while the third has been correlated to the FL eruption from Mount Etna. These recognitions provide a link of the Ohrid and Prespa lacustrine successions to other archives of the central Mediterranean area, like south Adriatic, Ionian, and south Tyrrhenian seas, lakes of southern Italy (Lago Grande di Monticchio, Pantano di San Gregorio Magno and Lago di Pergusa) and Balkans (Lake Shkodra).

  18. Tephrostratigraphy and tephrochronology of lakes Ohrid and Prespa, Balkans

    Directory of Open Access Journals (Sweden)

    R. Sulpizio

    2010-10-01

    Full Text Available Four cores from Balkans lakes Ohrid and Prespa were examined for recognition of tephra layers and cryptotephras, and the results presented along with the review of data from other two already published cores from Lake Ohrid. The six cores provide a previously unrealised tephrostratigraphic framework of the two lakes, and provide a new tephrostratigraphic profile (composite for the Balkans, which spans from the end of the Middle Pleistocene to the AD 472. A total of 12 tephra layers and cryptotephras were recognised in the cores. One is of Middle Pleistocene age (131 ka and correlated to the marine tephra layer P-11 from Pantelleria Island. Eight volcanic layers are Upper Pleistocene in age, and encompass the period between ca. 107 ka and ca. 31 ka. This interval contains some of the main regional volcanic markers of the central Mediterranean area, including X-6, X-5, Y-5 and Y-3 tephra layers. The other layers of this interval have been related to the marine tephra layers C20, Y-6 and C10, while one was for the first time recognised in distal areas and correlated to the Taurano eruption of probable Vesuvian origin. Three cryptotephras were of Holocene age. Two of which have been correlated to Mercato and AD 472 eruptions of Somma-Vesuvius, while the third has been correlated to the FL eruption from Mount Etna. These recognitions provide a link of the Ohrid and Prespa lacustrine successions to other archives of the central Mediterranean area, like south Adriatic, Ionian, and south Tyrrhenian seas, lakes of southern Italy (Lago Grande di Monticchio, Pantano di San Gregorio Magno and Lago di Pergusa and Balkans (Lake Shkodra.

  19. Tephrostratigraphy and tephrochronology of lakes Ohrid and Prespa, Balkans

    Directory of Open Access Journals (Sweden)

    R. Sulpizio

    2010-05-01

    Full Text Available Four cores from Balkans lakes Ohrid and Prespa were studied for recognition of tephra layers and cryptotephras, and the results presented along with the review of data from other two already published cores from Lake Ohrid. The six cores provide a previously unrealised tephrostratigraphic framework of the two lakes, and supply the first detailed tephrochronologic profile (composite for the Balkans, which spans from the end of the Middle Pleistocene to the end of the Ancient Age (AD 472. A total of 12 tephra layers and cryptotephras were recognised in the cores. One is of Middle Pleistocene age (131 ky and correlated to the marine tephra layer P-11 from Pantelleria Island. Eight volcanic layers are Upper Pleistocene in age, and encompass the period between ca. 107 ky and ca. 31 ky. This interval contains some of the main regional volcanic markers of the Central Mediterranean area, including X-6, X-5, Y-5 and Y-3 tephra layers. The other layers of this interval have been related to the marine tephra layers C20, Y-6 and C10, while one was for the first time recognised in distal areas and correlated to the Taurano eruption of probable Vesuvian origin. Three cryptotephras were of Holocene age. Two of which have been correlated to Mercato and AD 472 eruptions of Somma-Vesuvius, while the third has been correlated to the FL eruption from Mount Etna. These recognitions provide a link of the Ohrid and Prespa lacustrine successions to other archives of the Central Mediterranean area, like South Adriatic, Ionian, and South Tyrrhenian Seas, lakes of Southern Italy (Lago Grande di Monticchio, Pantano di San Gregorio Magno and Lago di Pergusa and Balkans (Lake Shkodra.

  20. The Balkan Theme in The Secret of Chimneys

    OpenAIRE

    Graham St. John Stott; Aysar Yaseen

    2016-01-01

    In The Secret of Chimneys (1925) Agatha Christie uses the all too familiar Balkan stereotypes of backwardness and brigandage, but not – as was usually the case at the time – as an Other to illustrate British virtue, but as a mirror to British vice. It is Britain, not the fictional Herzoslovakia, that is a nation of brigands. Herzoslovakia remains relatively unknown, as none of the novel’s scenes take place there, but it is described by disinterested observers as democratic and prosperous. In ...

  1. Ochratoxin A: Previous risk assessments and issues arising

    DEFF Research Database (Denmark)

    Walker, R.; Larsen, John Christian

    2005-01-01

    Ochratoxin A (OTA) causes nephropathy in all species tested with large sex and species differences in potency, pigs being most sensitive. It has been linked to Balkan endemic nephropathy (BEN) in humans. Embryotoxicity, teratogenicity, and immunotoxicity occur only at doses higher than those...

  2. Interstitial nephritis and interstitial nephropathy

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920710 A study of the cytomegalovirus-DNA in serum and renal tissue of patients-with IgA nephropathy. LIU Zhihong(刘志红),et al. Dept Nephrol, Jinling Hosp,Nanjing,210002. Nail Med J China 1992; 72(4): 198-200. Cytomegalovirus (CMV) has been suspectedto be involved in the pathogenesis of IgA nep-

  3. Lithium nephropathy: a case report

    OpenAIRE

    Raphael Reis Pereira-Silva; Debora Esperancini-Tebar

    2014-01-01

    Although widely used in the management of bipolar disorder, lithium may cause adverse kidney effects. The importance of the present study is to report the case of a 59-year-old woman who was under regular treatment with lithium for bipolar disorder and whose imaging studies demonstrated the presence of multiple renal microcysts, suggesting lithium nephropathy as main diagnostic hypothesis.

  4. Lithium nephropathy: a case report

    Directory of Open Access Journals (Sweden)

    Raphael Reis Pereira-Silva

    2014-01-01

    Full Text Available Although widely used in the management of bipolar disorder, lithium may cause adverse kidney effects. The importance of the present study is to report the case of a 59-year-old woman who was under regular treatment with lithium for bipolar disorder and whose imaging studies demonstrated the presence of multiple renal microcysts, suggesting lithium nephropathy as main diagnostic hypothesis.

  5. Overview of poverty and social exclusion in the Western Balkans

    Directory of Open Access Journals (Sweden)

    Matković Gordana

    2006-01-01

    Full Text Available During the last 15 years the entire Western Balkan region has undergone dramatic changes. With the fall of the Berlin wall and the disintegration of the former Yugoslavia, new states were formed and transition started, although in some countries it was quite delayed. Simultaneously, during the nineties, much of the region experienced wars and destruction, waves of refugees, internal displacement of population, devastation of the economy, demolition of institutions and impoverishment of citizens. Absolute poverty, determined through the estimation of household consumption at which families, after paying for essential non-food expenditures just attain minimal nutritional needs, in almost all of the Western Balkans is still relatively high, and is not showing significant tendencies of decreasing. A large concentration of the population and households just above the poverty line additionally demonstrates the challenges faced by the entire region while undergoing the transition process. In some countries extreme poverty, meaning that not even basic food needs can be met, has been registered. On the other hand, relative poverty, defined as the share of those who are excluded from the minimum acceptable way of life in states in which they live, is not particularly high. Due to the relatively high standard of living in the past and high expectations of the population that living standards would increase in a relatively short period of time, the subjective perception of poverty in the entire region is very much present. Groups that stand out as especially vulnerable and excluded are the unemployed, dependents and the less educated. At the level of the household, in some countries households with many children and elderly households are particularly vulnerable. The poorest often live in the rural areas and in the underdeveloped regions. In addition, especially vulnerable groups, who cannot even be completely covered by standard surveys, but are poor and

  6. Diabetic nephropathy: a national dialogue.

    Science.gov (United States)

    Breyer, Matthew D; Coffman, Thomas M; Flessner, Michael F; Fried, Linda F; Harris, Raymond C; Ketchum, Christian J; Kretzler, Matthias; Nelson, Robert G; Sedor, John R; Susztak, Katalin

    2013-09-01

    The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue (KRND) asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease. Several high-priority objectives for diabetic nephropathy were identified in data and sample collection, hypothesis generation, hypothesis testing, and translation promotion. The lack of readily available human samples linked to comprehensive phenotypic, clinical, and demographic data remains a significant obstacle. With data and biological samples in place, several possibilities exist for using new technologies to develop hypotheses. Testing novel disease mechanisms with state-of-the-art tools should continue to be the foundation of the investigative community. Research must be translated to improve diagnosis and treatment of people. The objectives identified by the KRND provide the research community with future opportunities for improving the prevention, diagnosis, and treatment of diabetic nephropathy.

  7. Lithium clearance in chronic nephropathy

    DEFF Research Database (Denmark)

    Kamper, A L; Holstein-Rathlou, N H; Leyssac, P P

    1989-01-01

    1. Lithium clearance measurements were made in 72 patients with chronic nephropathy of different aetiology and moderate to severely reduced renal function. 2. Lithium clearance was strictly correlated with glomerular filtration rate, and there was no suggestion of distal tubular reabsorption...... clearance data were independent of whether renal disease was of primarily glomerular or tubular origin and, further, were not influenced by long-term conventional antihypertensive treatment. 6. It is concluded that, even with a reduced kidney function, the data are compatible with the suggestion...... that lithium clearance may be a measure of the delivery of sodium and water from the renal proximal tubule. With this assumption it was found that adjustment of the sodium excretion in chronic nephropathy initially takes place in the distal parts of the nephron (loop of Henle, distal tubule and collecting duct...

  8. Lithium clearance in chronic nephropathy

    DEFF Research Database (Denmark)

    Kamper, A L; Holstein-Rathlou, N H; Leyssac, P P

    1989-01-01

    1. Lithium clearance measurements were made in 72 patients with chronic nephropathy of different aetiology and moderate to severely reduced renal function. 2. Lithium clearance was strictly correlated with glomerular filtration rate, and there was no suggestion of distal tubular reabsorption...... of lithium or influence of osmotic diuresis. 3. Fractional reabsorption of lithium was reduced in most patients with glomerular filtration rates below 25 ml/min. 4. Calculated fractional distal reabsorption of sodium was reduced in most patients with glomerular filtration rates below 50 ml/min. 5. Lithium...... that lithium clearance may be a measure of the delivery of sodium and water from the renal proximal tubule. With this assumption it was found that adjustment of the sodium excretion in chronic nephropathy initially takes place in the distal parts of the nephron (loop of Henle, distal tubule and collecting duct...

  9. HIV Associated Lupus Like Nephropathy

    OpenAIRE

    2014-01-01

    Background Human immunodeficiency virus type 1 (HIV-1)-seropositive patients are at a high risk for the development of a variety of acute and chronic renal diseases. Most patients with HIVAN are of African descent, presenting late in the course of their HIV-1 infection. The only reliable test to establish or rule out the presence of HIVAN (HIV associated nephropathy) is renal biopsy. The most common lesion associated with HIV is a focal segmental glomeruloscelerosis, but several times, other ...

  10. 3 CFR - Continuation of the National Emergency With Respect to the Western Balkans

    Science.gov (United States)

    2010-01-01

    ... International Emergency Economic Powers Act (50 U.S.C. 1701-1706), to deal with the unusual and extraordinary... Macedonia and elsewhere in the Western Balkans region, or (ii) acts obstructing implementation of the...

  11. Authoritarian Populism in Transitional Democracies of Western Balkans

    Directory of Open Access Journals (Sweden)

    Ljubomir Danailov FRCKOSKI

    2014-03-01

    Full Text Available The present text is dealing with a new form of populism, namely authoritarian populism in countries of the Western Balkans. The big picture of reforms processes taking place in some of them in a 10 year period toward the EU enlargement finished with more authoritarianism than democracy. The EU technocratic officials miss the real conclusions in this situation, and turned out to be supporters of the new generation of authoritarian rulers who are impressed more by Putin than EU-values. Brussels’ conclusion that something is wrong in this region is not followed by a scrupulous analysis of what is going on and in which direction! Bureaucrats generally underestimate the seriousness of authoritarian populism as an “alternative” to democracy in the region.

  12. Pleistocene horses (genus Equus in the central Balkans

    Directory of Open Access Journals (Sweden)

    Forsten Ann

    2003-01-01

    Full Text Available A review of the fossil horses of the genus Equus from the central Balkans, a mountainous area comprising Serbia and Montenegro, is presented in this paper. The time period covered by the finds is from the late Early to and including the Late Pleistocene, but the record is not complete: the dated finds are Late Pleistocene in age, while Early and Middle Pleistocene are poorly represented. The horses found resemble those from neighbouring countries from the same time period, probably showing the importance of river valleys as migration routes. The Morava River valley runs in a roughly south-to-north direction, connecting, via the Danube and Tisa River valleys the Hungarian Pannonian Plain in the north with northern Greece in the south, via the Vardar River valley in Macedonia. In Pleistocene, large mammals, including horses, probably used this route for dispersal.

  13. Minorities, mother countries, majority on the western Balkans

    Directory of Open Access Journals (Sweden)

    Andor Végh

    2012-02-01

    Full Text Available El cambio de dominio étnico más importante en Europa en los últimos veinte años es el que se ha dado en los Balcanes Occidentales. Estos cambios han tenido lugar tras los hechos de la Guerra desarrollada entre 1991 y 1995 y sus efectos llegan hasta nuestros días. En este ensayo se presenta la estructura de estos cambios y se analizan estos cambios en nuestros días a través de tres categorías de espacios étnicos: los núcleos de los espacios étnicos, los espacios mixtos y las zonas de contacto. Se presenta, igualmente, un espacio de cambios en el territorio que se modifica de forma simultánea.Palabras clave: Balcanes occidentales, etnicidad, núcleos de áreas étnicas, territorios de etnicidad mixta, zonas de contacto, proceso étnico.________________AbstractThe most significant changes of ethnic territories in Europe have happened on the Western Balkans. The majority of changes are related to wars in former Yugoslavia between 1991 and 1995, but processes that have started around the crisis are lasting ever since. We are trying to outline these changes and reveal some of the weak spots of the issue using three categories of ethnic spaces: core area of an ethnic territory, ethnically mixed territory, contact zones. Furthermore, the article gives a complex overview of the major territorial rearrangements, and the causes leading to them: the parallelly changing identities and ethnic territories.Keywords: West-Balkan, ethnicity, ethnical core areas, ethnicaly mixed territory, contact zones, ethnic processes.

  14. Analysis of the agricultural and rural development policies of the Western Balkan countries

    OpenAIRE

    BAJRAMOVIĆ Sabahudin; Bogdanov, Natalija; BUTKOVIĆ Jakub; DIMITROVSKI Dragi; Erjavec, Emil; GJECI Grigor; GJOKAJ Ekrem; HOXHA Bekim; STOMENKOVSKA Ivana Janeska; KONJEVIĆ Darko; KOTEVSKA Ana; MARTINOVIĆ Aleksandra; MIFTARI Iliriana; Nacka, Marina; OGNJENOVIĆ Dragana

    2016-01-01

    This report was prepared by a team of academic experts from Western Balkan (WB) countries coordinated by the Regional Rural Development Standing Working Group (SWG) in South-East Europe. The study targets EU candidate and potential candidate countries from the Western Balkan region (Albania, Bosnia and Herzegovina, Macedonia, Montenegro, Serbia and Kosovo*). The main objectives of the study is the monitoring and evaluation of agricultural policies in the period 2012-2014 and assessment of the...

  15. Tourism policy of Balkan countries: Review of national tourism development strategies

    OpenAIRE

    Dejan Metodijeski; Zoran Temelkov

    2014-01-01

    A different tourism policy created by various states is one of the primary factors for the existence and development of tourism, along with its natural and anthropogenic resources of specified destinations. The subject of this paper is the tourism policy of the Balkan countries, as seen through the prism of national strategies for the development of tourism and tourism products. The paper provides basic data for the Balkan countries such as: population, territory characteristics, number of...

  16. What Strategy Should Bulgaria Pursue to Track and Disrupt Terror Networks in the Balkans?

    Science.gov (United States)

    2014-03-01

    combination of ethnic and religious disputes, its economy, and its political weaknesses, Macedonia has become a country that is significantly...former Yugoslavia collapsed at the beginning of the 1990s, followed by the ethnic civil wars in Bosnia and Kosovo, the Balkans turned into an arena...of the 1990s, followed by the ethnic civil wars in Bosnia and Kosovo, the Balkans turned into an arena for the spread of Islamic fundamentalism and

  17. The National Guard State Partnership Program and Regional Security in the Western Balkans

    Science.gov (United States)

    2014-12-12

    through COCOMs. It links US states with partnering countries in order to promote SC.8 4 Library of Congress, “Congressional Research Service Careers ...Western Balkans in light of EU’s economic crisis and political indecision . The United States downsizing its presence in Europe creates a lucrative...sees an opportunity to expand its influence in the Western Balkans in light of EU’s economic crisis and political indecision and the current hold on

  18. Association of genetic variants with diabetic nephropathy.

    Science.gov (United States)

    Rizvi, Saliha; Raza, Syed Tasleem; Mahdi, Farzana

    2014-12-15

    Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, eNOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy.

  19. Association of genetic variants with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    Saliha; Rizvi; Syed; Tasleem; Raza; Farzana; Mahdi

    2014-01-01

    Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, e NOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy.

  20. Geo-Regional Security and Transformation After the Balkan's Wars and Kosova Independence

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Gjon Boriqi

    2014-02-01

    Full Text Available During the '90-ies the wars in the former territories of what was called Yugoslavia marked the end of a century plenty of wars and local armed conflicts. More than 140 million people died because of wars in the XX century. The war of Kosova was the last one in that century. The beginning of the XXI century stressed the necessity for a new way of thinking nationally, regionally and globally. The Balkans were often considered as a gun powder territory. All the Balkans states, someone more and someone less, have problems with each other. History was and remained very passionate within the Balkan countries. The case of Kosova is possibly the most sensitive in all this framework. After the proclamation of independence on February 17 2008, the concerns were high within the region and a new question was questioned: would the map of the Balkan peninsula change again to form another "Kosovo"? This article would give some details about the geopolitical situation in the Balkans focusing on Kosova and would try to establish e new way of making politics and diplomacy though deterrence and not offence. We will try to overpass history but without neglecting it, but by learning from its mistakes in order to bring a better Peace-Building aspect for the Balkan region.

  1. Nodular lesions and mesangiolysis in diabetic nephropathy.

    Science.gov (United States)

    Wada, Takashi; Shimizu, Miho; Yokoyama, Hitoshi; Iwata, Yasunori; Sakai, Yoshio; Kaneko, Shuichi; Furuichi, Kengo

    2013-02-01

    Diabetic nephropathy is a leading cause of end-stage renal failure all over the world. Advanced human diabetic nephropathy is characterized by the presence of specific lesions including nodular lesions, doughnut lesions, and exudative lesions. Thus far, animal models precisely mimicking advanced human diabetic nephropathy, especially nodular lesions, remain to be fully established. Animal models with spontaneous diabetic kidney diseases or with inducible kidney lesions may be useful for investigating the pathogenesis of diabetic nephropathy. Based on pathological features, we previously reported that diabetic glomerular nodular-like lesions were formed during the reconstruction process of mesangiolysis. Recently, we established nodular-like lesions resembling those seen in advanced human diabetic nephropathy through vascular endothelial injury and mesangiolysis by administration of monocrotaline. Here, in this review, we discuss diabetic nodular lesions and its animal models resembling human diabetic kidney lesions, with our hypothesis that endothelial cell injury and mesangiolysis might be required for nodular lesions.

  2. Balkans as a cultural symbol in the Serbian music of the first half of the twentieth century

    Directory of Open Access Journals (Sweden)

    Milanović Biljana

    2008-01-01

    Full Text Available Focus on the internalization of Western images in the Balkans has special significance in researching Serbian art. The functioning of Balkanism as it overlapped and intersected with Orientalism is indicated in the text by an examination of the cases of Petar Konjović, Miloje Milojević and Josip Slavenski, the three significant composers working in Serbia during the first half of the twentieth century. Their modernistic projects present different metaphors of the Balkans. Nevertheless each of them is marked by desire to change the Balkan image into a 'positive' one and thus stands as a special voice for Serbian and regional placing in European competition for musical spaces.

  3. Crescentic IgA nephropathy.

    Science.gov (United States)

    Abuelo, J G; Esparza, A R; Matarese, R A; Endreny, R G; Carvalho, J S; Allegra, S R

    1984-11-01

    We report five cases of crescentic IgA nephropathy. All are males, 16-60 years of age. One case each came to medical attention with uremia, nephrotic syndrome, and gross hematuria; two cases presented with microhematuria and proteinuria on routine urinalysis. All had hypertension, azotemia (serum creatinine 1.6-9.4 mg/dl), proteinuria (greater than 6 g/24 hr in four cases), hypoalbuminemia (less than 3 g/dl), and hematuria (gross in two cases). All progressed to end-stage renal failure renal failure ending in dialysis (three cases) or death from unrelated causes (two cases). Prednisone, 60 mg/day for 1 month in two patients (with two 1-g doses of iv methylprednisolone in 1 case) did not improve the serum creatinine level, but one patient subsequently experienced a less rapid fall in renal function. A crescentic glomerulonephritis was present in all biopsies (crescents in 31-80% of glomeruli; mean, 50%). The size and stage of the crescents were variable. Numerous glomeruli had focal or diffuse sclerosis. In all cases, there was a 3 or 4+ deposition of IgA. Low-intensity staining for IgG and IgM was noted in four and three patients, respectively. On electron microscopy, dense granular mesangial deposits were noted in all cases and in four patients capillary subepithelial deposits were also observed. This form of IgA nephropathy is not common, but some studies indicate that it may occur in about 5% of patients with IgA nephropathy.

  4. THE CULTURE OF COEXISTENCE AND PERCEPTION OF THE OTHER IN THE WESTERN BALKANS

    Directory of Open Access Journals (Sweden)

    Sibel Akova

    2015-04-01

    Full Text Available Throughout the 550 year Ottoman rule over the Balkan lands, where even today internal dynamics threaten peace and justice, how and through what means the Ottoman Empire achieved consistency, security and peace is a question to which a number of political scientists, sociologists, communication scientists and history researchers have sought an answer. The most interesting point of the question is that the peoples of the Balkans, a living museum comprising a number of different ethnic groups and religious beliefs, have reached the point where the culture of coexistence has been internalised and dynamics have moved from the conflict of identities to cultural integration. The Balkans are a bridge to the East from Europe and indeed to the West from Turkey, incorporating a patchwork political and cultural geography, the geopolitical location and a richness of culture and civilization, being one of the areas attracting the attention of researchers from different disciplines and capturing the imagination of the peoples of the world throughout history. Balkan studies are almost as difficult as climbing the peaks in the areas and meaningful answers cannot be reached by defining the area on a single parameter such as language, culture or traditions, while the phenomenon of the other can also be observed within the culture of coexistence in this intricate and significant location. Different ethnic groups with different cultures, such as the Southern Slavs (Bosniaks, Montenegrans, Serbs, Croats and Slovenes as well as Turks, Albanians, Bulgarians, Balkan Jews, Balkan Romany and Wallachians (Romanians and Greeks. Although these peoples may have different religious beliefs, in the ethnically rich Balkan region, religion, language, political and cultural differences are vital in the formation of a mosaic, making the discourse of coexistence possible and creating common values and loyalties, breaking down differences. The Serbian and Montenegrin peoples

  5. Lithium nephropathy: unique sonographic findings.

    Science.gov (United States)

    Di Salvo, Donald N; Park, Joseph; Laing, Faye C

    2012-04-01

    This case series describes a unique sonographic appearance consisting of numerous microcysts and punctate echogenic foci seen on renal sonograms of 10 adult patients receiving chronic lithium therapy. Clinically, chronic renal insufficiency was present in 6 and nephrogenic diabetes insipidus in 2. Sonography showed numerous microcysts and punctate echogenic foci. Computed tomography in 5 patients confirmed microcysts and microcalcifications, which were fewer in number than on sonography. Magnetic resonance imaging in 2 patients confirmed microcysts in each case. Renal biopsy in 1 patient showed chronic interstitial nephritis, microcysts, and tubular dilatation. The diagnosis of lithium nephropathy should be considered when sonography shows these findings.

  6. The Present Situation and the Future Perspectives of Foreign Direct Investment in Balkan Region

    Directory of Open Access Journals (Sweden)

    Arjan Qefalia

    2009-10-01

    Full Text Available The past decade has witnessed increased globalization of the world economy as result of technological changes, trade liberalization and privatization policies. Balkan countries as developing nations are in the realization process of the globalization changes of the world economy. Being in the process for entry into the EU, many changes are being done to integrate with the global economic trends. The research has shown that after the fall of communism in the 1990s the Balkan Region brought significant political and economic changes. The change in attitude led to a removal of direct blockage for FDI. As a result, continued deregulation and privatization has been widespread. However, history of FDI is relatively short for Balkan Region in comparison with other countries. The economy opened up capital inflows only at the beginning of 1990s, and is still showing low shares in the total of Central and Eastern European flow. Despite Balkans competitive advantage due to its geographical location and its resources, it is still far from other Central European countries in achieving the same level of FDI. This situation came as a result of: political instability, low intraregional trade, the small size of national markets, huge institutional corruption and weak judiciary system. Among the more successful Balkan recipients of FDI has been Bulgaria and Romania, while Greece has been a major source of FDI for the transition economies of the Balkan region. Greek investment is driven in part by the availability of low cost labor in the nearby transition economies. The focus of this article is to analyze and evaluate the current performance of FDI in Balkan Region and how the governments can improve this performance.

  7. Sonographic findings in Gouty Nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Young; Jeon, Woo Ki; Kim, Ho Kyun; Kim, Yong Soo; Han, Chang Yul; Kim, Young Tong; Han, Sung Tag; Lee, Yoon Woo [Inje University College of Medicine, Seoul (Korea, Republic of)

    1994-09-15

    Ultrasound(US) findings of hyperechoic renal medulla in gouty nephropathy were compared with clinical features such as serum uric acid level to evaluate its usefulness in determination of the treatment and prognosis. A retrospective review of US of 36 cases of qouty arthritis was classified into four groups according to the medullary echogenicity (O :normal, grade I: renal medulla as isoechoic as renal cortex, grade II; heterogeneous increased echogenicity of renal medulla than that of renal cortex, grade III: the echogenicity of all renal medulla higher than that of renal cortex with renal contour deformity) which were compared with the serum urate level and associated conditions. Nephrocalcinosis and nephrolithiasis were analyzed through the KUB and the RGB. The degree of hyperechoic renal medulla was related to the level of serum uric acid, and in group IV, six cases of obstructive uropathy (nephrocalcinosis and nephrolithiasis) showed deformed renal contour. Associated conditions such as hypertension, alcoholism, diabetes mellitus and drug abuse were distributed in relation to the degree of hyperechoic renal medullas. US findings of hyperechoic renal mebulla was related with uric acid level in gouty nephropathy and thus could be valuable for treatment decision and prediction of prognosis.

  8. Comprehensive approach to diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Bancha Satirapoj

    2014-09-01

    Full Text Available Diabetic nephropathy (DN is a leading cause of mortality and morbidity in patients with diabetes. This complication reflects a complex pathophysiology, whereby various genetic and environmental factors determine susceptibility and progression to end-stage renal disease. DN should be considered in patients with type 1 diabetes for at least 10 years who have microalbuminuria and diabetic retinopathy, as well as in patients with type 1 or type 2 diabetes with macroalbuminuria in whom other causes for proteinuria are absent. DN may also present as a falling estimated glomerular filtration rate with albuminuria as a minor presenting feature, especially in patients taking renin–angiotensin–aldosterone system inhibitors (RAASi. The pathological characteristic features of disease are three major lesions: diffuse mesangial expansion, diffuse thickened glomerular basement membrane, and hyalinosis of arterioles. Functionally, however, the pathophysiology is reflected in dysfunction of the mesangium, the glomerular capillary wall, the tubulointerstitium, and the vasculature. For all diabetic patients, a comprehensive approach to management including glycemic and hypertensive control with RAASi combined with lipid control, dietary salt restriction, lowering of protein intake, increased physical activity, weight reduction, and smoking cessation can reduce the rate of progression of nephropathy and minimize the risk for cardiovascular events. This review focuses on the latest published data dealing with the mechanisms, diagnosis, and current treatment of DN.

  9. Patterns of national identity development among the Balkan orthodox Christians during the nineteenth century

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    Markovich Slobodan G.

    2013-01-01

    Full Text Available The paper analyses the development of national identities among Balkan Orthodox Christians from the 1780s to 1914. It points to pre-modern political subsystems in which many Balkan Orthodox peasants lived in the Ottoman Empire at the beginning of the nineteenth century. The Serbian and Greek uprisings/revolutions are analyzed in the context of the intellectual climate of the Enlightenment. Various modes of penetration of the ideas of the Age of Revolution are analyzed as well as the ways in which new concepts influenced proto-national identities of Serbs and Romans/Greeks. The author accepts Hobsbawm’s concept of proto-national identities and identifies their ethno-religious identity as the main element of Balkan Christian Orthodox proto-nations. The role of the Orthodox Church in the formation of ethno-religious proto-national identity and in its development into national identity during the nineteenth century is analyzed in the cases of Serbs, Romans/ Greeks, Vlachs/Romanians and Bulgarians. Three of the four Balkan national movements fully developed their respective national identities through their own ethnic states, and the fourth (Bulgarian developed partially through its ethnic state. All four analyzed identities reached the stage of mass nationalism by the time of the Balkan Wars. By the beginning of the twentieth century, only Macedonian Slavs kept their proto-national ethno-religious identity to a substantial degree. Various analyzed patterns indicate that nascent national identities coexisted with fluid and shifting protonational identities within the same religious background. Occasional supremacy of social over ethnic identities has also been identified. Ethnification of the Orthodox Church, in the period 1831-1872, is viewed as very important for the development of national movements of Balkan Orthodox Christians. A new three-stage model of national identity development among Balkan Orthodox Christians has been proposed. It is

  10. BUSINESS ENVIRONMENT – THE CASE OF WESTERN BALKAN COUNTRIES

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    Zijad Džafić

    2014-11-01

    Full Text Available This paper investigates and compares development of the Entrepreneurship and Small and Medium - sized Enterprises (SMEs sector and different obstacles for development of this sector in the Western Balkan countries (WBCs. Many evidence from the countries of central Europe show that the development of SMEs and entrepreneurship is a key factor for a successful transformation from command to market based economy in WBCs. SMEs create new jobs, products and services, help in restructuring former state enterprises, which is very important for transition countries, and generate government revenues. Also, SMEs stimulate private ownership and entrepreneurial skills and innovations. Aspecial accent in this paper is put on many international reports and datasets relevant to the assessment of business environment in this region. In this paper, the author uses only some such as: The Global Competitiveness Report of World Economic Forum, World Bank’s Doing Business Index, Heritage Foundation's Index of Economic Freedom, European Charter for Small Enterprises and Small Business Act of OECD and European Commission (EC and Indicators of Business, Corruption and Crime in WBCs of the United Nations Office on Drugs and Crime (UNODC. The author has come to the conclusion that, in respect of SMEs, WBCs lag behind the countries in the European Union. This article aims to analyze the system of regulation and administrative facilitation aspects of doing business in the above - mentioned countries and, whether or not this system stimulates, the development of private SMEs and entrepreneurship.

  11. Understanding the motives for food choice in Western Balkan Countries.

    Science.gov (United States)

    Milošević, Jasna; Žeželj, Iris; Gorton, Matthew; Barjolle, Dominique

    2012-02-01

    Substantial empirical evidence exists regarding the importance of different factors underlying food choice in Western Europe. However, research results on eating habits and food choice in the Western Balkan Countries (WBCs) remain scarce. A Food Choice Questionnaire (FCQ), an instrument that measures the reported importance of nine factors underlying food choice, was administered to a representative sample of 3085 adult respondents in six WBCs. The most important factors reported are sensory appeal, purchase convenience, and health and natural content; the least important are ethical concern and familiarity. The ranking of food choice motives across WBCs was strikingly similar. Factor analysis revealed eight factors compared to nine in the original FCQ model: health and natural content scales loaded onto one factor as did familiarity and ethical concern; the convenience scale items generated two factors, one related to purchase convenience and the other to preparation convenience. Groups of consumers with similar motivational profiles were identified using cluster analysis. Each cluster has distinct food purchasing behavior and socio-economic characteristics, for which appropriate public health communication messages can be drawn.

  12. Geoculture world system, access to Balkan and Albania

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    Ilirjan Çukaj

    2015-03-01

    Full Text Available If culture as a term covers a broad range of relations and social behavior, mutually implicated in influential and economic cycles of the global system, then it becomes wordy geoculture. Geoculture system is used as a term by Wallerstein (2004 who had treated it as a concept largely unused and under a theory of geoculture which plays an important role in the present world system. The theses that is presented in this article is that the global trajectory in the Balkan region is increasing from culture and that, it is imperative to establish a strategic culture direction and management, which, in turn, should be formed not only as a principal need, but also as an obligation of social state institutions to find the viable solutions of the global market policy, economy and culture. And in response to the challenging question the culture of integration becomes imperative now facing nationalism. Albania will have to manage perceptions, fears and realities arising from the above mentioned phenomenon, to establish a balance between the “inside” and “outside” views. In this sense main challenge of Albania is the management of cultural globalization to get the most of opportunities despite the risk of losing ground globally

  13. Western Balkan States and the European Union Enlargement

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    Gelina Maliqi (Ramolli

    2011-07-01

    Full Text Available For half a century, European Union-(EU has pursued ever-deeper integration while taking in new members. It’s marked as an important step in relationship deepening between EU and Western Balkans-(WBs where Albania is part of. In 2003, EU declared that the future of WBs is within EU. Initially it adopted a generous strategy that linked the timetable for accession to the pace of reform in WBs. The declaration contained a conditional promise; EU would consider WBs for membership only if they reached EU standards. The EU was motivated by usual economic considerations connected to enlargement and a desire to increase regional stability. The enlargement process regarding Albania will bring several reforms on different fields. Our country will benefit from a share of multibeneficiary funds for competitiveness, SMEs, energy efficiency and banking sector regulation. This presentation handles out these main issues: EU policy and the enlargement process regarding Albania inspecting the way and progress done up to now by our country, the main features of our national EUcoordination system, concluding in a SWOT Analysis of EU-coordination system in Albania. Eventually, I believe that Albania being part of WBs is at one time an opportunity and a challenge for the future of EU.

  14. A Comparison of Stereotypes of German and Turkish Students towards Balkans

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    Gürcan Ültanır

    2016-01-01

    Full Text Available Effective emotional thoughts like attitudes, stereotyped judgments and preconceptions are dependent on both collective and individual experiences. Experiences like reading an article or watching a movie that is based on a context determined by the curriculum might cause individual or collective discrimination towards different ethnic or cultural groups among students in a country. This study aims to explore the difference between two nations which are the Turkish nation that has many cultural and political bonds with Balkans in the history and the German nation, which is a nation that has little or no bonds with the Balkans. The main aim of the study is to figure out if the stereotypes towards Balkans can change according to the country in which an individual has grown up. MANOVA was used to figure out the difference between two capitals with regard to stereotypes towards Balkans. Findings of the study indicated that negative stereotype scores of students significantly changed according to the country in which students grew up, whereas no significant difference was found for positive stereotype scores. Moreover, it was found that Turkish students have more negative stereotypes towards Balkans than German students

  15. Alu insertion polymorphisms in the Balkans and the origins of the Aromuns.

    Science.gov (United States)

    Comas, D; Schmid, H; Braeuer, S; Flaiz, C; Busquets, A; Calafell, F; Bertranpetit, J; Scheil, H-G; Huckenbeck, W; Efremovska, L; Schmidt, H

    2004-03-01

    We have analysed 11 human-specific Alu insertion polymorphisms in the Balkans to elucidate the origins of the Aromuns, a linguistic isolate inhabiting scattered areas in the Balkan Peninsula. Four Aromun samples (two from the Republic of Macedonia, one from Albania, and one from Romania) and five neighbouring populations (Macedonians, Albanians, Romanians, Greeks, and Turks) were analysed by means of genetic distances, principal components and analyses of the molecular variance (AMOVA). Three hypotheses were tested: Aromuns are Romanophonic Greeks; the result of a Romanian southward migration; or local descendants of the Thracians. The analyses show that the Aromuns do not constitute a homogeneous group separated from the rest of the Balkan populations. Grouping by language or geography does not explain the genetic differences observed in the region, suggesting a lack of genetic structure in the area. Aromuns do not seem to be particularly related to Greeks, Romanians, or to other Romance speakers. The Aromuns might have their origin to the south of the Danube river, with extensive gene flow with the neighbouring populations. The present results suggest a common ancestry of all Balkan populations, including Aromuns, with a lack of correlation between genetic differentiation and language or ethnicity, stressing that no major migration barriers have existed in the making of the complex Balkan human puzzle.

  16. Clinical and pathological aspects of analgesic nephropathy

    OpenAIRE

    Nanra, R. S.

    1980-01-01

    1 Analgesic nephropathy is part of the analgesic syndrome which has gastrointestinal, haematological, cardiovascular, psychological and psychiatric, and pregnancy and gonadal manifestations; premature ageing may also be a feature.

  17. The course of incipient diabetic nephropathy

    DEFF Research Database (Denmark)

    Christensen, Cramer; Mogensen, C E

    1985-01-01

    With the aim of defining the transitional phase from normal or near normal albumin excretion to overt diabetic nephropathy, 23 male diabetics of more than 7 years' duration, below 40 years of age and a baseline urinary albumin excretion above 15 micrograms/min but without clinical proteinuria...... (incipient diabetic nephropathy) were studied. For comparison 18 normals, 23 diabetics with normal albumin excretion and 10 patients with overt nephropathy were also examined. Diastolic blood pressure (DBP) was elevated to 88 +/- 9 mmHg (mean +/- S.D.) compared to patients with normal urinary albumin...... excretion: 80 +/- 7 (S.D.) (2p = 0.13%) but was below pressures in patients with overt diabetic nephropathy 109 +/- 15 (2p = 0.002%). Glomerular filtration rate (GFR) was elevated to 142 +/- 21 ml/min (mean +/- S.D.) compared to 132 +/- 9 in patients with normal urinary albumin excretion (2p = 4.3%). Renal...

  18. Lack of mitochondrial DNA structure in Balkan donkey is consistent with a quick spread of the species after domestication.

    Science.gov (United States)

    Pérez-Pardal, L; Grizelj, J; Traoré, A; Cubric-Curik, V; Arsenos, G; Dovenski, T; Marković, B; Fernández, I; Cuervo, M; Alvarez, I; Beja-Pereira, A; Curik, I; Goyache, F

    2014-02-01

    A total of 132 mtDNA sequences from 10 Balkan donkey populations were analysed to ascertain their regional genetic structure and to contribute to the knowledge of the spreading of the species after domestication. The Balkan donkey sequences were compared with those from 40 Burkina Faso donkeys as an African outgroup to account for possible local Balkan scenarios. The 172 sequences gave 62 different haplotypes (55 in Balkan donkey). Virtually all the analysed populations had haplotypes assigned to either Clade 1 or Clade 2 even though the relative proportion of Clade 1 or 2 haplotypes differed across populations. Geographical maps constructed using factors computed via principal component analysis showed that the Balkan donkey populations are not spatially structured. AMOVA confirmed a lack of genetic structure in Balkan donkey mtDNA. Balkan populations were poorly differentiated (ΦST  = 0.071). Differentiation between the Balkan donkey and the African outgroup also was low. The lack of correspondence between geographical areas and maternal genetic structure is consistent with the hypothesis suggesting a very quick spread of the species after domestication. The current research illustrates the difficulties to trace routes of expansion in donkey, as the species has no geographical structure.

  19. Mechanism of hypertension in diabetic nephropathy

    OpenAIRE

    Nazar, Chaudhary Muhammad Junaid

    2014-01-01

    High prevalence of hypertension is observed in diabetic patients of both the types. Diabetic nephropathy is one of the major reason for high morbidity, mortality and financial burden in such hypertensive diabetic patients. For this review, electronic databases including PubMed/Medline, Embase, Cochrane and Google scholar were searched from 1990-2013. Multiple inter-related factors are responsible for the development of hypertension and therefore nephropathy in the chronic diabetic patients. M...

  20. Neurology of endemic skeletal fluorosis

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    Reddy D

    2009-01-01

    Full Text Available Endemic skeletal fluorosis is widely prevalent in India and is a major public health problem. The first ever report of endemic skeletal fluorosis and neurological manifestation was from Prakasam district in Andhra Pradesh in the year 1937. Epidemiological and experimental studies in the endemic areas suggest the role of temperate climate, hard physical labor, nutritional status, presence of abnormal concentrations of trace elements like strontium, uranium, silica in water supplies, high fluoride levels in foods and presence of kidney disease in the development of skeletal fluorosis. Neurological complications of endemic skeletal fluorosis, namely radiculopathy, myelopathy or both are mechanical in nature and till date the evidence for direct neurotoxicity of fluoride is lacking. Prevention of the disease should be the aim, knowing the pathogenesis of fluorosis. Surgery has a limited role in alleviating the neurological disability and should be tailored to the individual based on the imaging findings.

  1. Light chain immunofluorescence in various nephropathies

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    Megha S Uppin

    2011-01-01

    Full Text Available Context: Light chain immunofluoresence (IF in renal biopsy is routinely used in the diagnosis of light chain deposition disease (LCDD, amyloidosis and cast nephropathy. Light chain predominance has also been reported in certain glomerulopathies like IgA nephropathy. However, pathogenesis of this pattern of deposition in various glomerulopathies is uncertain. Aim: To discuss the pathogenesis and utility of light chain IF in nephropathies. Setting and Design: Retrospective study. Materials and Methods: The pattern of light chain IF and light microscopic diagnosis in 306 cases of various nephropathies was reviewed. Direct IF was done in all these cases with commercial fluorescence (Fluoresciene Isothiocynate conjugated polyclonal rabbit anti-human antisera against IgM, IgG, IgA, C3, C1q, kappa and lambda light chains. Results: Light chain deposits were seen in 240 (78.43% cases. In IgA nephropathy, lupus nephritis and post-infectious glomerulonephritis (PIGN, lambda positivity was more as compared to kappa. Light chain deposits in LCDD and membranous nephropathy were more kappa type. The IF pattern in amyloidosis was not consistent. Conclusion: The pathogenesis of light chain predominance in glomerulopathies is not clear and it depends on isoelectric point and size of the immune complex. Light chain IF should be performed routinely in all the renal biopsies.

  2. Rare and Endemic Plants in the Southern Mountain Ecosystems of Albania, their Threats and Diversity

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    ERMELINDA MAHMUTAJ

    2015-03-01

    Full Text Available The study highlights flora and vegetation richness in the mountain ecosystems in Southern Albania, focusing mainly on Çika, Këndërvica, and Tomorri Mts. The data are collected in more than 100 relevés during field trips, carried out in periods of intensive vegetation. It shows the presence of 11 endemic taxa, 23 nearendemics and more than 60 Balkan endemics. Two new species for science are described recently (Gymnospermium maloi Kit Tan & Shuka and Campanula aureliana Bogdanović, Rešetnik, Brullo & Shuka and some others are confirmed about 100 years after (Sesleria albanica Ujhelyi and Stachys sericophylla Halacsy. Main threats, especially for the endemics and rare taxa of the southern region of Albania, are presented in this study, with recommendations for future steps. Some Natura2000 habitats are identified and a relevance of different habitat types like EUNIS, and Syntaxonomic classifications are linked together. The main aim of this study was the identification and presentation of floristic and vegetation values of this wide natural ecosystem and putting them into the function of science. The results indicate the area as the richest in the country, due to the insignificant influence of human factor and diversity of climate and terrestrial elements.

  3. BIOCHEMICAL SCREENING OF DIABETIC NEPHROPATHY

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    Vivek

    2016-01-01

    Full Text Available Diabetic nephropathy is a clinical syndrome characterized by the following- Persistent albuminuria (>300mg/d or >200μg/min, that is confirmed on at least 2 occasions 3-6 months apart diabetic, progressive decline in the Glomerular Filtration Rate (GFR, elevated arterial blood pressure. The earliest biochemical criteria for the diagnosis of diabetic nephropathy is the presence of micro-albumin in the urine, which if left untreated will eventually lead to End-Stage Renal Disease (ESRD. Micro-albuminuria refers to the excretion of albumin in the urine at a rate that exceeds normal limits. The current study was conducted to establish the prevalence of micro-albuminuria in a sequential sample of diabetic patients attending hospital and OPD Clinic to determine its relationship with known and putative risk factors to identify micro- and normo-albuminuric patients in their sample for subsequent comparison in different age, sex, weight and creatinine clearance of the micro- and normo-albuminuric patients. This cross-sectional analytical study was conducted in one hundred patients at Saraswathi Institute of Medical Sciences, Anwarpur, Hapur, U. P. Patients having diabetes mellitus in different age group ranging from 30 to 70 years were selected. Data was analysed by SPSS software. Micro-albuminuria was observed in 35% in patients with type 2 diabetes mellitus. It was observed that 65% patients were free from any type of albuminuria. Also micro-albuminuria was present in 10% of the patients less than 50 yrs. of age, while 15% of the patients more than 50 yrs. of age were having micro-albuminuria. There was a statistically significant correlation of micro-albuminuria with duration of diabetes. Incidence of micro-albuminuria increases with age as well as increased duration of diabetes mellitus. Our study shows that only 5% patients developed macro-albuminuria. Glycosylated haemoglobin and fasting plasma glucose was significantly raised among all these

  4. Amadori albumin in diabetic nephropathy

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    Km. Neelofar

    2015-01-01

    Full Text Available Nonenzymatic glycation of macromolecules in diabetes mellitus (DM is accelerated due to persistent hyperglycemia. Reducing sugar such as glucose reacts non enzymatically with free €- amino groups of proteins through series of reactions forming Schiff bases. These bases are converted into Amadori product and further into AGEs. Non enzymatic glycation has the potential to alter the biological, structural and functional properties of macromolecules both in vitro and in vivo. Studies have suggested that amadori as well as AGEs are involved in the micro-macro vascular complications in DM, but most studies have focused on the role of AGEs in vascular complications of diabetes. Recently putative AGE-induced patho-physiology has shifted attention from the possible role of amadori-modified proteins, the predominant form of the glycated proteins in the development of the diabetic complications. Human serum albumin (HSA, the most abundant protein in circulation contains 59 lysine and 23 arginine residues that could, in theory be involved in glycation. Albumin has dual nature, first as a marker of intermediate glycation and second as a causative agent of the damage of tissues. Among the blood proteins, hemoglobin and albumin are the most common proteins that are glycated. HSA with a shorter half life than RBC, appears to be an alternative marker of glycemic control as it can indicate blood glucose status over a short period (2-3 weeks and being unaffected by RBCs life span and variant haemoglobin, anemia etc which however, affect HbA1c. On the other hand, Amadori albumin may accumulate in the body tissues of the diabetic patients and participate in secondary complications. Amadori-albumin has potential role in diabetic glomerulosclerosis due to long term hyperglycaemia and plays an important role in the pathogenesis of diabetic nephropathy. This review is an approach to compile both the nature of glycated albumin as a damaging agent of tissues and as an

  5. Tubulointerstitial disease in diabetic nephropathy

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    Tonolo G

    2014-03-01

    Full Text Available Giancarlo Tonolo, Sara Cherchi SC Diabetologia Aziendale ASL 2 Olbia, Hospital San Giovanni di Dio, Olbia, Italy Abstract: Diabetes mellitus is the major cause of end stage renal disease (ESRD. We cannot predict which patient will be affected. ESRD patients suffer an extremely high mortality rate, due to a very high incidence of cardiovascular disease. Several randomized, prospective studies have been conducted to quantify the impact of strict glycemic control on morbidity and mortality, and have consistently demonstrated an association between strict glycemic control and a reduction in ESRD. Within the past 20 years, despite the implementation of treatments that were presumed to be renoprotective, diabetes mellitus has continued to rank as the leading cause of ESRD, which clearly indicates that we are still far from understanding the mechanisms involved in the initiation of ESRD. Progressive albuminuria has been considered as the sine qua non of diabetic nephropathy, but we know now that progression to diabetic nephropathy may well happen in the absence of initial microalbuminuria. The search for new biomarkers of early kidney damage has received increasing interest, since early identification of the pathways leading to kidney damage may allow us to adopt measures to prevent the development of ESRD. Most of these biomarkers are deeply influenced by environment, genetics, sex differences, and so on, making it extremely difficult to identify the ideal biomarker to target. At present, there are no new drugs that come close to providing the solutions we desire for our patients (ie, reducing complications. Even when used in combination with standard care, renal complications are, at best, only modestly reduced, at the considerable expense of additional pill burden and exposure to serious off-target effects. In this review, some of the hypothesized mechanisms of this heterogeneous disease will be considered, with particular attention to the tubule

  6. ANALYSIS OF THE WESTERN BALKAN COUNTRIES’ COMPETITIVENESS DETERMINANTS USING THE KEI METHODOLOGY

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    Bojan KRSTIC

    2014-07-01

    Full Text Available The purpose of this paper is to analyse the development of knowledge economy and its importance for the competitiveness of the Western Balkans countries. The aim of the research is to evaluate the development degree of knowledge economy in the Western Balkans countries through the comparison of relevant indicators with the European Union countries. The research information base is the official World Bank data about values ​​of "the knowledge economy index" (KEI. Comprehensive analysis leads us to conclusions about: a the relative positions of the Western Balkans countries in relation to the EU countries, b the development state of knowledge economy in analysed countries according to the pillars of the knowledge economy index. The paper concludes by highlighting the implications and recommendations for conducting the economic policy in the area ​​which encourages the development of knowledge economy and improves competitiveness.

  7. Collaborative investigations on thoron and radon in some rural communities of Balkans.

    Science.gov (United States)

    Zunić, Z S; Celiković, I; Tokonami, S; Ishikawa, T; Ujić, P; Onischenko, A; Zhukovsky, M; Milić, G; Jakupi, B; Cuknić, O; Veselinović, N; Fujimoto, K; Sahoo, S K; Yarmoshenko, I

    2010-10-01

    This paper deals with the results of the first-field use in the Balkans, i.e. Serbia and Republic of Srpska (Bosnia and Hercegovina), of a passive polycarbonate Mark II type and poliallyldiglycol carbonate (Cr-39) alpha track detectors sensitive to thoron as well as to radon. Both types of solid state nuclear track detectors were designed and supplied by National Institute of Radiological Sciences (NIRS), Chiba, Japan. The commercial names for these detectors which all have been field tested in Balkan rural communities are known as: UFO and RADUET passive discriminative radon/thoron detectors. No database of thoron and thoron progeny concentrations in dwellings in Serbia or Balkans region exist, and as a result, the level of exposure of the Serbian population to thoron and its progeny is unknown so far.

  8. Turkey Entering the European Union Through the Balkan Doors: in the Style of a Great Power?

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    Bedrudin Brljavac

    2011-06-01

    Full Text Available Confronting an increasing EU opposition from a number of influential member states to its membership the AKP government adopted a multilateral approach to its foreign policy making resulting in dynamic economic and diplomatic policies with the countries from Asia, Africa, Latin America, and the Balkans region. In this article we analyzed the effects and consequences of a paradigmatic shift in Turkish foreign policy in the Western Balkans in relation to the country's EU membership prospects. Through its pro-active economic and diplomatic initiatives in the region Turkey has been proving itself as indispensable country for the European Union membership. Thus, if the Turkish government concentrates more on solving its internal problems and continues its pro-active diplomacy in Western Balkans, among other regions, it could become not only a regional but also a global power.

  9. Paul Garde, Les Balkans, héritages et évolutions

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    Anaïs Krawczykowska

    2010-06-01

    Full Text Available Les Balkans, ce territoire montagneux (balkan signifiant « Montagne » en turc aussi appelé « Europe du sud », est plus que jamais au cœur de l'actualité. Or il semblerait que la géographie soit un paramètre bien insuffisant à sa définition. Menaçante pour les uns, prometteuse pour les autres, l'ex-Yougoslavie laisse apparaître de nombreux enjeux stratégiques, aussi bien politiques qu'économiques ou encore historiques. Ces dernières années ont remis les pays des Balkans sur le devant de la sc...

  10. Effects of the world economic crisis on exports in the CEEC: Focus on the Western Balkans

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    Bjelić Predrag

    2013-01-01

    Full Text Available The world economic crisis that paralyzed the world economy in 2008 and 2009 had a profound impact on all countries in the world. Due to the interconnectedness of national economies the crisis spread rapidly from its centre in the United States to the world. There were two main transmission channels for the spread of the crisis between countries - international trade and the exchange of private capital between states in the form of foreign direct investment (FDI. This economic downturn has greatly influenced the domestic economic stability of the Western Balkan economies. The Western Balkan countries have shaped their economic policy towards European Union (EU membership, resulting in a high degree of liberalization in international economic relations accompanied by a commitment to free international capital movement. Since this region has close economic ties with the EU the crisis spread to the region very quickly, manifesting itself in decreasing regional exports to the EU market and a downward trend of FDI inflow to the region. This paper will focus on the impact of the world economic crisis on the Western Balkan economies and especially on their exports and FDI inflow. Our empirical analysis, based on panel data, uses a wider sample of Central and Eastern European Countries (CEEC which includes the Western Balkans, since we wanted to analyze if the effects of the economic crisis in the Western Balkans are specific or are common to most countries in transition. The analysis shows that Western Balkan exports have suffered due to the crisis, but reveals some interesting results on the different dynamics of export flows which depend on regional trade integration for their destination.

  11. Distribution and diversity of Arctic-Alpine species in the Balkans

    DEFF Research Database (Denmark)

    Stevanovic, Vladimir; Vukojicic, Snezana; Sinzar-Sekulic, Jasmina;

    2009-01-01

    The distributions of 77 Arctic-Alpine species in the Balkans are mapped and the centers of their richness and diversity presented. Within the Dinaric Alps these are Mts Vranica, Durmitor, and Prokletije; in the Scardo-Pindhic mountains, Šarplanina-Rudoka-Korab form a continuous chain; in the Rhod......The distributions of 77 Arctic-Alpine species in the Balkans are mapped and the centers of their richness and diversity presented. Within the Dinaric Alps these are Mts Vranica, Durmitor, and Prokletije; in the Scardo-Pindhic mountains, Šarplanina-Rudoka-Korab form a continuous chain...

  12. Effects of capital markets development on economic growth of Western Balkan countries

    Directory of Open Access Journals (Sweden)

    MSc. Artor Nuhiu

    2011-12-01

    Full Text Available Through this research paper we have tried to elaborate the issue whether capital market development is an alternative towards economic growth and economic prosperity of developing countries in general, the Western Balkan countries in particular. The focus of the paper is to study the effects of proper functioning of capital markets and their im-pact on increasing the level of savings, capital investments and in locating relevant resources for long-term financing of the economy. The research paper presents positive and negative arguments, linking the establishment and development of a capital market and its impact on economic development of developing countries, particularly Western Balkan countries.

  13. Nomadic pastoralism in the Early Bronze Age of the central Balkans evaluation of background knowledge

    Directory of Open Access Journals (Sweden)

    Porčić Marko

    2008-01-01

    Full Text Available The aim of the paper is to examine background knowledge about the orga­nizational properties of mobile pastoral groups in order to assess the likelihood of the existence of pastoral nomads in the Early Bronze Age in the central Balkans. The patterning found by A. L. Johnson (2002 is taken as a point of departure for the cross-cultural analysis conducted in this study. Johnson’s findings are in the main corroborated. Acquired knowledge about the workings of pastoral societies suggests that highly mobile pastoral groups should not be expected in the Early Bronze Age of the central Balkans.

  14. [Neuroethics and bioethics--implications of Balkanization controversy].

    Science.gov (United States)

    Kagawa, Chiaki

    2009-01-01

    There have been considerable disputes the positioning of neuroethics as a new field since its emergence in 2002. It is the novelty of the neuroethical issues and the necessity for updated moral approaches to them that leading exponents of neuroethics have emphasized; advances in neurosciences have created an entirely new field of moral inquiries that the conventional bioethics had never noticed. Futher, as neuroethics embraces the subdivision of ethics in neuroscience, it should take precedence over bioethics, which depends on the fundamental moral concepts without questioning their bases. Many bioethicists have squarely opposed these insistences and thereby detected the claim of neuroethics exceptionalism: the asserted newness of issues comes mainly from the ignorance of exponents of this new field regarding accumulated bioethical inquiries, so that the overlapping concerns between bioethics and neuroethics are passed on to the future by them. Moreover, bioethicists point out that the recent tendency of Balkanization in the field of bioethics could endanger the integrity of moral investigations. Subfields of bioethics, such as geneethics, neuroethics, nanoethics and so on, originate consecutively, entail wastage of valuable time and money, and increase the risk of fragmentizing moral considerations in an inconsistent way. By reviewing this controversy between neuroethics and bioethics, I argue that the relevant scientific investigations and technologies, which have appeared to promote the proliferation of bioethical sub-disciplines to date, are beginning to converge into 1 complex that demands not the division into subspecialities but the novel integration of bioethical inquiries: it is time to attempt the unification of bioethical applied ethics for moral considerations regarding nano-bio-info-cogno convergent technologies.

  15. STUDY OF Salmo GENUS (PISCES, SALMONIDAE ON THE BALKAN PENINSULA

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    Simo Georgijev

    2011-03-01

    Full Text Available Author disputes the position of the authors K o t t e l a t (1997 and K o t t e l a t & F r e y h o f (2007 about the existence of several species belonging to the Salmo genus in some parts of Balkan Peninsula: Salmo aphelios Kottelat, 1997; Salmo balcanicus (Karaman, 1927; Salmo farioides (Karaman, 1938; Salmo labrax Pallas, 1814; Salmo letnica (Karaman, 1924; Salmo lumi Poljakov, Filipi & Basho, 1958; Salmo macedonicus (Karaman, 1924; Salmo montenigrinus (Karaman, 1933; Salmo pelagonicus Karaman, 1938; Salmo peristericus Karaman, 1938; Salmo taleri (Karaman, 1932. Majority of those species were described by dr. Stanko Karaman, the author who is, regarding the number of described species of European freshwater fishes, on the second place, just behind Carl Linnaeus. It is hardly believable that four trout species were formed in a small and oligotrophic microhabitat like Ohrid Lake, or three species in the Vardar River, knowing that the factor of geographic isolation doesn’t exist in either of the habitats. The author’s position is that all of these species are actually just types of one, highly plastic regarding the micro ecological conditions and phenotypic manifestations, species: Salmo trutta (Linnaeus, 1785. The author supports his opinion by his own results, as well the results of other scientists, obtained through studies of ecology and taxonomy of the brown trout in fluent and still water microhabitats. Also the author suggests that it is unacceptable to apply the terminology immanent to the anthropogenic factor in a sphere of another scientific area where such factor doesn't exist (agronomy-race and biology-natural selection.

  16. A Case of BK Nephropathy without Detectable Viremia or Viruria

    OpenAIRE

    Kamel, Mahmoud; Kadian, Manish; Salazar, Maria Nieva; Mohan, Prince; Self, Sally; Srinivas, Titte; Salas, Maria Aurora Posadas

    2015-01-01

    Patient: Male, 49 Final Diagnosis: BK nephropathy without detectable viremia or viruria Symptoms: — Medication: — Clinical Procedure: Kidney biopsy Specialty: Nephrology Objective: Unusual clinical course Background: BK nephropathy is an evolving challenge among kidney transplant recipients. Diagnosis of BK nephropathy depends on the presence of BK viral inclusions on renal biopsy. Most cases of BK nephropathy are preceded by BK viremia or viruria. Case Report: We report a case of BK nephropa...

  17. Improving nutrition surveillance and public health research in Central and Eastern Europe/Balkan Countries using the Balkan Food Platform and dietary tools.

    Science.gov (United States)

    Gurinović, Mirjana; Milešević, Jelena; Novaković, Romana; Kadvan, Agnes; Djekić-Ivanković, Marija; Šatalić, Zvonimir; Korošec, Mojca; Spiroski, Igor; Ranić, Marija; Dupouy, Eleonora; Oshaug, Arne; Finglas, Paul; Glibetić, Maria

    2016-02-15

    The objective of this paper is to share experience and provide updated information on Capacity Development in the Central and Eastern Europe/Balkan Countries (CEE/BC) region relevant to public health nutrition, particularly in creation of food composition databases (FCDBs), applying dietary intake assessment and monitoring tools, and harmonizing methodology for nutrition surveillance. Balkan Food Platform was established by a Memorandum of Understanding among EuroFIR AISBL, Institute for Medical Research, Belgrade, Capacity Development Network in Nutrition in CEE - CAPNUTRA and institutions from nine countries in the region. Inventory on FCDB status identified lack of harmonized and standardized research tools. To strengthen harmonization in CEE/BC in line with European research trends, the Network members collaborated in development of a Regional FCDB, using web-based food composition data base management software following EuroFIR standards. Comprehensive nutrition assessment and planning tool - DIET ASSESS & PLAN could enable synchronization of nutrition surveillance across countries.

  18. “Early Classical Settlements” and the Iron Age of the Central Balkans: Issues of Ethnic Identity

    Directory of Open Access Journals (Sweden)

    Ivan Vranić

    2016-03-01

    Full Text Available In the Balkan archaeologies, ethnic identity has been traditionally treated as a stable and monolithic category, readily recognizable in the material culture. The issue of “ethnogenesis” of the Palaeo-Balkan “peoples” is the dominant topic and the basic research subject in culture-historical archaeology, today regarded as the consequence of the modern European nationalisms. Starting from the constructivist point, the paper seeks to examine the interpretations of ethnicity in the Balkan Iron Age, on the example of the so-called “early Classical settlements” – a series of mutually very similar fortified settlements located in the vast lands of the Balkan hinterland, today in the territory of several modern states. These settlements are broadly dated into the period from the 5th to the 3rd centuries BC, and have traditionally been interpreted as the final phase of the ethnogenesis of the Palaeo-Balkan communities, supposed to have been living in “tribal states”, whose population has been recognized as “people” or even “nation”. In the traditional literature, the ethnic characteristics have been readily recognized, projecting directly the modern socio-political structures onto the communities of the past that could have been founded on completely different group identity or political organization. The paper deals with the issue of the political aspects of these interpretations in various Balkan countries, favoring certain Palaeo-Balkan communities, and an attempt is made to contextualize these nationalistic narratives into the present.

  19. A new Classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy.

    Science.gov (United States)

    Haneda, Masakazu; Utsunomiya, Kazunori; Koya, Daisuke; Babazono, Tetsuya; Moriya, Tatsumi; Makino, Hirofumi; Kimura, Kenjiro; Suzuki, Yoshiki; Wada, Takashi; Ogawa, Susumu; Inaba, Masaaki; Kanno, Yoshihiko; Shigematsu, Takashi; Masakane, Ikuto; Tsuchiya, Ken; Honda, Keiko; Ichikawa, Kazuko; Shide, Kenichiro

    2015-03-01

    The Joint Committee on Diabetic Nephropathy has revised its Classification of Diabetic Nephropathy (Classification of Diabetic Nephropathy 2014) in line with the widespread use of key concepts, such as the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). In revising the Classification, the Committee carefully evaluated, as relevant to current revision, the report of a study conducted by the Research Group of Diabetic Nephropathy, Ministry of Health, Labor and Welfare of Japan. Major revisions to the Classification are summarized as follows: (i) eGFR is substituted for GFR in the Classification; (ii) the subdivisions A and B in stage 3 (overt nephropathy) have been reintegrated; (iii) stage 4 (kidney failure) has been redefined as a GFR <30 mL/min/1.73 m(2), regardless of the extent of albuminuria; and (iv) stress has been placed on the differential diagnosis of diabetic nephropathy versus non-diabetic kidney disease as being crucial in all stages of diabetic nephropathy.

  20. A new classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy.

    Science.gov (United States)

    Haneda, Masakazu; Utsunomiya, Kazunori; Koya, Daisuke; Babazono, Tetsuya; Moriya, Tatsumi; Makino, Hirofumi; Kimura, Kenjiro; Suzuki, Yoshiki; Wada, Takashi; Ogawa, Susumu; Inaba, Masaaki; Kanno, Yoshihiko; Shigematsu, Takashi; Masakane, Ikuto; Tsuchiya, Ken; Honda, Keiko; Ichikawa, Kazuko; Shide, Kenichiro

    2015-02-01

    The Joint Committee on Diabetic Nephropathy has revised its Classification of Diabetic Nephropathy (Classification of Diabetic Nephropathy 2014) in line with the widespread use of key concepts such as the estimated glomerular filtration rate (eGFR) and chronic kidney disease. In revising the Classification, the Committee carefully evaluated, as relevant to current revision, the report of a study conducted by the Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan. Major revisions to the Classification are summarized as follows: (1) eGFR is substituted for GFR in the Classification; (2) the subdivisions A and B in stage 3 (overt nephropathy) have been reintegrated; (3) stage 4 (kidney failure) has been redefined as a GFR less than 30 mL/min/1.73 m(2), regardless of the extent of albuminuria; and (4) stress has been placed on the differential diagnosis of diabetic nephropathy versus non-diabetic kidney disease as being crucial in all stages of diabetic nephropathy.

  1. The complete genome sequence of a Crimean-Congo Hemorrhagic Fever virus isolated from an endemic region in Kosovo

    Directory of Open Access Journals (Sweden)

    Dedushaj Iusuf

    2008-01-01

    Full Text Available Abstract The Balkan region and Kosovo in particular, is a well-known Crimean-Congo hemorrhagic fever (CCHF endemic region, with frequent epidemic outbreaks and sporadic cases occurring with a hospitalized case fatality of approximately 30%. Recent analysis of complete genome sequences of diverse CCHF virus strains showed that the genome plasticity of the virus is surprisingly high for an arthropod-borne virus. High levels of nucleotide and amino acid differences, frequent RNA segment reassortment and even RNA recombination have been recently described. This diversity illustrates the need to determine the complete genome sequence of CCHF virus representatives of all geographically distinct endemic areas, particularly in light of the high pathogenicity of the virus and its listing as a potential bioterrorism threat. Here we describe the first complete CCHF virus genome sequence of a virus (strain Kosova Hoti isolated from a hemorrhagic fever case in the Balkans. This virus strain was isolated from a fatal CCHF case, and passaged only twice on Vero E6 cells prior to sequence analysis. The virus total genome was found to be 19.2 kb in length, consisting of a 1672 nucleotide (nt S segment, a 5364 nt M segment and a 12150 nt L segment. Phylogenetic analysis of CCHF virus complete genomes placed the Kosova Hoti strain in the Europe/Turkey group, with highest similarity seen with Russian isolates. The virus M segments are the most diverse with up to 31 and 27% differences seen at the nt and amino acid levels, and even 1.9% amino acid difference found between the Kosova Hoti and another strain from Kosovo (9553-01. This suggests that distinct virus strains can coexist in highly endemic areas.

  2. Diagnosis and treatment of primary glomerular diseases Membranous nephropathy, focal segmental glomerulosclerosis and IgA nephropathy.

    NARCIS (Netherlands)

    Deegens, J.K.J.; Wetzels, J.F.M.

    2005-01-01

    Membranous nephropathy, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy are the most frequent and important primary glomerulopathies. Idiopathic membranous nephropathy and primary FSGS usually present with a nephrotic syndrome with or without renal insufficiency, whereas IgA nephropath

  3. Competitiveness, Trade with the EU and Labour Markets: Challenges for the Western Balkans

    Directory of Open Access Journals (Sweden)

    Botrić Valerija

    2016-12-01

    Full Text Available This paper focuses on the relationship between exporting and the labour markets of the Western Balkan economies within a macroeconomic and microeconomic framework. Within the macroeconomic framework we investigate the Western Balkan countries’ evolution of the bilateral intra-industry trade share with European Monetary Union members and compare this with the differences in bilateral unit labour cost dynamics. The microeconomic analysis rests on enterprise-level cross section data collected during the crisis period and investigates whether exporters help to create additional jobs in the region in comparison to entrepreneurs oriented towards national market. The results show that trade patterns between Western Balkan economies and EMU trading partners did not exhibit any significant changes in trend. On the other hand, it seems that during the recession period most Western Balkan economies adjusted their unit labour costs, probably in order to boost competitiveness. Microeconomic analysis revealed that, although there are some positive differences between exporters and non-exporters, exporters do not create additional employment.

  4. Tendency of exports technology structure and exports concentration in the Balkan economies 2000-2012

    Directory of Open Access Journals (Sweden)

    Goran Nikolić

    2013-11-01

    Full Text Available At the beginning of the 21st century there was a tendency of mild improvement of the quality of exports of Balkan countries, which can be traced through a slight increase in the share of goods of higher levels of processing (skill-intensive manufactures and medium- and high-tech products. In spite of that, the quality level of exports from Balkan economies lags greatly behind the countries in the EU and to a lesser extent the Central European economies in transition, with some signs of catching-up over time. The stagnant and relatively high levels of Export concentration ratio and low share of high processing goods are indicating that Balkan economies are increasingly specializing in price-sensitive markets.For export success it is of great importance to have the transfer of modern technology and investment, especially FDI, in competitive sectors which would 'spread' export offer. Improved approach to employment policy regulations and an extensive re-organization of science and education system is needed. One of the reasons for Balkan countries’ weak export lies in industrial policy, which would be able to promote innovation, product quality and high technological standards.

  5. Consumption and perception of processed fruits in the Western Balkan region

    NARCIS (Netherlands)

    Sijtsema, S.J.; Zimmermann, K.L.; Cvetkovic, M.; Stojanovic, Z.; Spiroski, I.; Milosevic, J.; Mora, C.; Butigan, R.; Mugosa, B.; Esteve, M.; Pohar, J.

    2012-01-01

    The aim of the study was to gain a better understanding of the consumption and perception of processed fruits in Western Balkan countries in order to support consumer-oriented product development. In-depth interviews (n = 183) were used to explore the consumption of processed fruits, the motives to

  6. Chalybion Omissum (Kohl, 1889 (Hymenoptera: Sphecidae, Sceliphrini: New Records from the Balkan Peninsula (Southern Bulgaria

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    Olszewski Piotr

    2014-09-01

    Full Text Available The paper presents new information about the occurrence of Chalybion omissum (KOHL, 1889 in central part of Balkan Peninsula (southern Bulgaria. Seven specimens were caught at 4 sites: N of Kurdzhali (UTM: LG61, Usstrem village (MG55, NE of Kalimantsi village (GL09, NE of Madzharovo (MG01.

  7. Mapping the potential for decentralized energy generation based on RES in Western Balkans

    Directory of Open Access Journals (Sweden)

    Schneider Daniel R.

    2007-01-01

    Full Text Available Although the countries of the Western Balkans are mostly electrified, there are still regions which do not have access to the electricity network or where the network capacity is insufficient. For the most part such areas are under special care of the state (i. e. underdeveloped, devastated by war, depopulated, on islands or in mountainous regions. Since the decentralized energy generation covers a broad range of technologies, including many renewable energy technologies that provide small-scale power at sites close to the users, such concept could be of interest for these locations. This paper identifies the areas in Western Balkans where such systems could be applied. Consideration is given to geographical locations as well as possible applications. Wind, hydro, solar photovoltaic, and biomass conversion systems were taken into consideration. Since the renewable energy sources data for Western Balkans region are rather scarce, the intention was to give a survey of the present situation and an estimate of future potential for decentralized energy generation based on renewable energy sources. The decentralized energy generation based on renewable energy sources in Western Balkans will find its niche easier for the users that will produce electricity for their own needs and for the users located in remote rural areas (off-grid applications.

  8. Petrographic and mineral characterization of Balkan coals and their solid waste products from coal preparation

    Energy Technology Data Exchange (ETDEWEB)

    Yossifova, M. [Bulgarian Academy of Sciences, Sofia (Bulgaria). Institute of Applied Mineralogy

    1995-12-31

    This paper is part of a complex petrographic, mineralogical and chemical investigation on Balkan bituminous coals and their solid waste products from coal preparation. The petrographic and phase-mineralogical composition in ten composite samples and four water extracts have been studied by optical microscopy, scanning electron microscopy and X-ray diffraction. 4 refs., 4 tabs.

  9. Balkan Flint’ – fiction and/or trajectory to Neolithization: Evidence from Bulgaria

    Directory of Open Access Journals (Sweden)

    Maria Gurova

    2012-05-01

    Full Text Available The paper focuses on the current state of research and knowledge about ‘Balkan flint’ (hereinafter BF and trajectories flowing from the BF problem to the bigger and increasingly complex problem of the Neolithization of the eastern Balkans. The emergence and consolidation of the BF problem within the research agenda of specialists working on Balkan prehistory is briefly traced, as well as the confusing and inconsistently repetitive use of the term BF leading to some ‘mythologisation’ of the topic.A particular section of the paper represents the thoughts of the author on the conceptual meaning of BF in the context of the Balkan Neolithization debate, because until now its role has not been fully appreciated and recognized. Several theories and scenarios of the emergence and spread of the Neolithic in present-day Bulgaria are reviewed through the evidence of the particular Early Neolithic flint toolkits consisting in representative (retouched blades made from BF and attributed to the diagnostic features of the Early Neolithic package/culture.

  10. Agenda-Setting for VET Policy in the Western Balkans: Employability versus Social Inclusion

    Science.gov (United States)

    Bartlett, Will; Pagliarello, Marina Cino

    2016-01-01

    For the last decade, the Western Balkan countries have sought to modernise their vocational education and training (VET) systems, adapting them to the needs of their emerging market economies. Within the framework of the EU accession process, the policy agenda for VET policies has been strongly influenced by a range of international and domestic…

  11. THE BALKANS BETWEEN THE EU AND NATO: FOCUSING ON THE FORMER YUGOSLAVIA

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    Mamoru Sadakata

    2006-10-01

    Full Text Available The fragmentation of Yugoslavia has wrought extensive political and social changes in the Balkans and Europe more generally. After the collapse of communism and the breakup of Yugoslavia, many Balkan countries have transformed their political system and have begun to forge new foreign and security policy. Some of them have already joined the EU and NATO, and some are about to access these organizations. But the Western Balkan states seem to be farther in the future. In regard to the former Yugoslavia, the United States, European states and international organizations, such as the EU, NATO and UN, have attempted to engage and manage this breakup on an individual and collective basis. They have greatly influenced the process of the post-conflict nation building of this region. From this viewpoint, the paper discusses the political and social transformation of the Balkans after the breakup of the Yugoslav conflict, and the role of the EU and NATO in the process of the democratization and nation building in the former Yugoslavia. Moreover, attention is paid to the features of the involvement of the EU and NATO in the former Yugoslav conflict. In the process of Yugoslav fragmentation one can see the ‘Eastern Question’ revisited and the ‘Powder keg of Europe’ once again rising to its brim.

  12. Immunoglobulin A nephropathy: Basic characteristics

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    Petrović Lada

    2003-01-01

    Full Text Available Introduction Immunoglobulin A nephropathy (IgAN is one of the most common forms of primary glomerulonephritis in many countries. Most clinical features of IgAN point to a renal problem, such as recurrent macroscopic hematuria or asymptomatic microscopic hematuria and proteinuria. Pathologic features of IgAN present with different types and different degrees of glomerular tubulointerstitial and vascular lesions. The aim of this study was detailed analysis of clinical and laboratory findings, as well as findings of immunofluorescence and light microscopy. We also investigated associations between these factors. Material and methods We investigated 60 patients who underwent renal biopsy. The study was partly retrospective and partly prospective. Results The average age of patients was 34.19 years. Male female ratio was 2.33:1. IgAN was most frequently asymptomatic (83.33% as microhematuria and proteinuria, while gross hematuria was found in 16.667%. Renal biopsy material was analyzed by light microscopy revealing changes in all glomerular structures. Immunofluorescence microscopy demonstrated dominant IgA deposits. This study established association of glomerulosclerosis with clinical features of disease. Discussion and conclusions IgAN frequently develops in the 4th decade of life, mostly in males and presents as asymptomatic (83.33%. Patohistological changes include all glomerular structures. There is no specific serological test for IgAN, but pathological changes affect clinical features of the disease, as proteinuria and increase of creatinine concentration.

  13. IgM nephropathy revisited.

    Science.gov (United States)

    Mubarak, Muhammed; Kazi, Javed I

    2012-01-01

    IgM nephropathy (IgMN) is an idiopathic immune complex-mediated glomerulopathy that was first described as a distinct disease in a nephropathology literature in 1978. Here, a historical review and the current status of IgMN in the light of world literature and the current experience will be presented. The Pubmed (www.pubmed.gov) search was made for articles on IgMN as the sole subject of the study or where it constituted a significant number of cases in a biopsy series in the world literature written in English. A total of 41 articles were found. A critical review of the literature was made. Soon after 1978, a series of reports were published mostly from the western world, but the interest in the entity did not withstand the test of time. No substantial basic medical research was carried out and the disease was largely ignored by the western researchers. More recently, a flurry of articles have appeared in the literature on the topic, mostly from tropical countries, and have renewed the interest in the entity. However, most of the current literature on IgMN is based on clinical observations, and experimental models and mechanistic studies of IgMN are lacking. There is an urgent need to develop consensus based criteria for the diagnosis of the condition, as well as, to focus the research on mechanistic studies to understand the pathogenesis of the disease better.

  14. Role of Mindin in Diabetic Nephropathy

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    Maki Murakoshi

    2011-01-01

    Full Text Available A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2 is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM proteins. Recent studies showed that mindin is essential for initiation of innate immune response and represents a unique pattern-recognition molecule in the ECM. Previously, we demonstrated that the levels of urinary mindin in patients with type 2 diabetes were higher than those in healthy individuals. We propose that urinary mindin is a potent biomarker for the development of diabetic nephropathy.

  15. Contrast-induced nephropathy after computed tomography

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    Luciano da Silva Selistre

    2015-03-01

    Full Text Available Introduction: Contrast induced nephropathy is the third most prevalent preventable cause of acute kidney injury in hospitalized patients. It defined as an absolute increase in serum creatinine ≥ 0.5 mg/dL and relative ≥ 25% increase. Objective: We studied the risk factors to intravenous injection contrast nephropathy after computed tomography. Methods: We studied 400 patients prospectively. Results: The incidence of contrast induced nephropathy, with an absolute or a relative increase were 4.0% and 13.9%, respectively. Diabetes and cardiac failure were independent risk factors for CIN a relative increase de serum creatinine (O.R.: 3.5 [95% CI: 1.92-6.36], p < 0.01, 2.61 [95% CI: 1.14-6.03%], p < 0.05, respectively. Conclusions: We showed association between uses of intravenous injection contrast after computed tomography with acute injury renal, notably with diabetes and heart failure.

  16. Angiotensin receptor blockers in diabetic nephropathy

    DEFF Research Database (Denmark)

    Parving, Hans-Henrik; Andersen, Steen; Jacobsen, Peter

    2004-01-01

    The activity of the renin-angiotensin-aldosterone system (RAAS) is elevated both in the circulation and in the renal tissue of diabetic and nondiabetic nephropathies. The increased RAAS activity plays an important role in the hemodynamic and nonhemodynamic pathogenetic mechanisms involved in kidney...... with diabetic nephropathy have demonstrated that angiotensin II receptor blockers (ARB) induce favorable changes in systemic blood pressure, renal hemodynamics, and proteinuria similar to those induced by angiotensin-converting enzyme (ACE) inhibition. Studies have revealed the optimal renoprotective dose...... in diabetic nephropathy. In addition, dual RAAS blockade is safe and well tolerated. Impaired autoregulation of glomerular filtration rate (GFR); demonstrated with some blood pressure-lowering agents implies disturbances in the downstream transmission of the systemic blood pressure into the glomerulus...

  17. Inner Otherness as a Source of Fear: Elements of Horror in Balkan Travelogues

    Directory of Open Access Journals (Sweden)

    Sanja Lazarević-Radak

    2016-03-01

    Full Text Available Travel fiction has created numerous Others, assigning them an ontologically unstable status, while the traditional travelogue spread a fear of the dark interior of Europe, presenting images of daily political strife, assassinations, wars and uprisings. Just like the Gothic novel, which entertained its readers with images of ruins and gloomy structures in Eastern Europe, the travelogue spread a fear of the Balkans through Europe, depicting the Balkans as a place that could pose a threat to the entire continent. While enjoying the mysterious terror of the Gothic novel, Europe also derived a kind of pleasure from the shocking images that were to be found in travelogues from the Balkans. The paper re-examines the elasticity of the boundaries of the travelogue genre, and identifies convenient transformations of certain parts of the travelogue into text aimed at inspiring terror, shocking and appalling its readers. The transformations show that it is impossible to draw a strict boundary between travel fiction and travelogues, and at the same time reveal the hidden discourse used by both genres. The parallel presence of awareness of the geographic identity of the Balkans as European, and of the aspiration to depict them as the strange inner Otherness of Europe, is accompanied by the production of terrifying images. Although these images cannot be viewed solely as a threat of "reverse colonization", the assumption that hybridity is the basis on which the terrifying nature of the Balkans is produced is re-examined. The travelogue chapters, sections and illustrations assume the features of horror, particularly body horror, revealing Europe’s fear of the possibility of the Orient infiltrating the "body of the Occident", or of the possibility of the latter being infected by elements of "alien" i.e. Oriental culture.

  18. Treatment of Diabetic Nephropathy with Acupuncture

    Institute of Scientific and Technical Information of China (English)

    CHU Qin; WANG Lin; LIU Guo-zhen; HAN Chou-ping

    2007-01-01

    Objective: to observe the clinical efficacy of acupuncture on diabetic nephropathy.Methods: altogether 54 cases were randomly allocated into acupuncture group (30 cases) and control group of western medications (24 cases), the latter was treated with routine western medication, while the former was combined acupuncture based on routine western medication,and the treatment course of the two groups were both 30 days. Results: the effect of treatment group was superior to the control group (P<0.05). Conclusion: acupuncture can improve symptoms of diabetic nephropathy, lower blood glucose, urine albumin, blood urine nitrogen,and creatinine and improve the function of kidney.

  19. Remission and regression of diabetic nephropathy

    DEFF Research Database (Denmark)

    Hovind, Peter; Tarnow, Lise; Parving, Hans-Henrik

    2004-01-01

    diabetic patients with overt nephropathy, remission (decrease in albuminuria to diabetic nephropathy (rate of decline in GFR treatment. Furthermore, remission of nephrotic-range albuminuria......Diabetic kidney disease is considered to be an irreversible and inexorable progressive disease. Therefore, prevention of development of ESRD is extremely important. Animal studies have demonstrated that regression of existing renal morphologic lesions is feasible. In a sizable fraction of type 1...... in diabetic patients, an aggressive multifactorial approach, aiming at lowering blood pressure and albuminuria, and improving glycemic control, must be applied....

  20. Lymphoplasmacytic lymphoma causing light chain cast nephropathy.

    Science.gov (United States)

    Pérez, Nuria S; Garcia-Herrera, Adriana; Rosiñol, Laura; Palos, Lily; Santiago, Evelyn; Espinosa, Gerard; Solé, Manel; Campistol, Josep M; Quintana, Luis F

    2012-01-01

    Plasma cell dyscrasias are frequently associated with kidney disease through the production of monoclonal immunoglobulin but with a diverse set of pathologic renal patterns. While almost all patients with a renal biopsy showing a cast nephropathy have myeloma, kidney involvement associated with pathological immunoglobulin light chains and lymphoma is rare. To our knowledge, this is the first report of a cast nephropathy associated with lymphoplasmacytic lymphoma. We emphasize the relation between light chain deposition and renal dysfunction in this disease with production of light chains. A therapeutic approach that decreases light chain production appears to be warranted in these patients.

  1. [Physiopathology of nephropathy studied with contrast media].

    Science.gov (United States)

    Morales Buenrostro, L E; Tellez Zenteno, J F; Torre Delgadillo, A

    2000-01-01

    For the technological advances in diagnostic and therapeutic procedures, the use of intravenous contrast media in the hospital is more and more frequent. It can produce acute renal failure secondary to its nephrotoxicity known as contrast media nephropathy. This review describes the pathophysiologic mechanisms of contrast media injury, including cytotoxicity caused by hyperosmoloarity of contrast media, the hemodynamic factors and the role of the renin-angiotensin system, prostaglandins, oxygen free radicals, endothelin-1, adenosine, nitric oxide and others. The understanding of this information is of vital importance for the development of prophylactic strategies for contrast media nephropathy.

  2. SORBS1 gene, a new candidate for diabetic nephropathy

    DEFF Research Database (Denmark)

    Germain, Marine; Pezzolesi, Marcus G; Sandholm, Niina

    2015-01-01

    AIMS/HYPOTHESIS: The genetic determinants of diabetic nephropathy remain poorly understood. We aimed to identify novel susceptibility genes for diabetic nephropathy. METHODS: We performed a genome-wide association study using 1000 Genomes-based imputation to compare type 1 diabetic nephropathy...... consistently and significantly (p diabetic nephropathy. The minor rs1326934-C allele was less frequent in cases than in controls (0.34 vs 0.43) and was associated with a decreased risk for diabetic nephropathy (OR 0.70; 95% CI 0.60, 0.82). However, this association was not observed...... in a second stage with two additional diabetic nephropathy cohorts, the All Ireland-Warren 3-Genetics of Kidneys in Diabetes UK and Republic of Ireland (UK-ROI; p = 0.15) and the Finnish Diabetic Nephropathy (FinnDiane; p = 0.44) studies, totalling 2,142 cases and 2,494 controls. Altogether, the random...

  3. Epigenetic modifications and diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Marpadga A. Reddy

    2012-09-01

    Full Text Available Diabetic nephropathy (DN is a major complication associated with both type 1 and type 2 diabetes, and a leading cause of end-stage renal disease. Conventional therapeutic strategies are not fully efficacious in the treatment of DN, suggesting an incomplete understanding of the gene regulation mechanisms involved in its pathogenesis. Furthermore, evidence from clinical trials has demonstrated a “metabolic memory” of prior exposure to hyperglycemia that continues to persist despite subsequent glycemic control. This remains a major challenge in the treatment of DN and other vascular complications. Epigenetic mechanisms such as DNA methylation, nucleosomal histone modifications, and noncoding RNAs control gene expression through regulation of chromatin structure and function and post-transcriptional mechanisms without altering the underlying DNA sequence. Emerging evidence indicates that multiple factors involved in the etiology of diabetes can alter epigenetic mechanisms and regulate the susceptibility to diabetes complications. Recent studies have demonstrated the involvement of histone lysine methylation in the regulation of key fibrotic and inflammatory genes related to diabetes complications including DN. Interestingly, histone lysine methylation persisted in vascular cells even after withdrawal from the diabetic milieu, demonstrating a potential role of epigenetic modifications in metabolic memory. Rapid advances in high-throughput technologies in the fields of genomics and epigenomics can lead to the identification of genome-wide alterations in key epigenetic modifications in vascular and renal cells in diabetes. Altogether, these findings can lead to the identification of potential predictive biomarkers and development of novel epigenetic therapies for diabetes and its associated complications.

  4. Vesicoureteral reflux and reflux nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, H.S.

    Vesicoureteral reflux (VUR) is mainly a primary phenomenon due to incontinence of the ureterovesical junction, mostly affecting a pediatric population. During micturition cystourethrography (MCU) reflux into the kidney - intrarenal reflux (IRR) - is occasionally seen. In areas with IRR the kidney surface may subsequently be depressed and the papillae retracted (reflux nephropathy (RN)). VUR may lead to hypertension and/or end-stage renal failure. Most commonly, VUR is discovered during evaluation for urinary tract infection, but it may also be present in patients with hypertension, toxemia of pregnancy, chronic renal failure and proteinuria, and it may be found in siblings of patients with VUR. For the time being VUR is demonstrated at radiographic MCU, whereas RN is diagnosed by demonstration of focal scars and of abnormal parenchymal thickness at urography. In children with VUR and no abnormalities of calyces or parenchymal defects standardized measurement of the parenchymal thickness at three sites may identify kidneys which are likely to develop focal scars. Quantitation of focal scarring should be performed in connection with a measure of the overall kidney size. The occurrence of IRR is dependent of the papillary morphology, intrapelvic pressure and urine flow. There may be an important relationship between renal ischemia and IRR in producing a 'vicious circle of deleterious effects' which, combined with parenchymal extravasation, may lead to RN. Treatment of VUR includes medical and surgical management. Since renal scarring may occur in infancy, prevention should focus on infants and young children. Infants and young children with severe VUR may have normal urograms. Therefore a MCU should also be performed, preferably with the recommended standardized technique. (orig.).

  5. Creolization and balkanization as a result of language (dialect) contact. Is the origin of mixed languages universal?

    OpenAIRE

    Michał Głuszkowski

    2015-01-01

    Creolization and balkanization as a result of language (dialect) contact. Is the origin of mixed languages universal? There are several types of language contact depending on the relations between languages. The article focuses on the results of language contact with multi- and unidirectional influence: balkanization, pidginization, creolization and other types of contact – why not all of them result in mixing codes. The author considers various theoretical approaches to describe language...

  6. Diabetic nephropathy in Surinamese South Asian subjects

    NARCIS (Netherlands)

    Chandieshaw, Prataap Kalap; Chandie Shaw, Prataap Kalap

    2008-01-01

    This thesis focuses on the incidence and risk factors for nephropathy in diabetic and non-diabetic Surinamese South Asians. The Surinamese South Asians, originally descended from the North-East India. Due to the former colonial bounds with the Netherlands, a relatively youn

  7. Diabetic nephropathy: Prescription trends in tertiary care

    Directory of Open Access Journals (Sweden)

    Devi D

    2008-01-01

    Full Text Available Diabetic nephropathy is a leading cause of end stage renal disease. Drug utilization studies could promote rational drug use. The objective of this study was to evaluate prescribing trends in hospitalized patients with diabetic nephropathy. A prospective, observational study was conducted in a tertiary care hospital. The demographic, disease and treatment data of patients with diabetic nephropathy were collected for a period of six months and analysed. Drugs were classified using World Health Organization recommended Anatomic Therapeutic Chemical classification. A total of 755 drugs (7.4 drugs per prescription were prescribed to 102 study patients, who were all hypertensive and in late stages of diabetic nephropathy. Drug classes with largest representation were those acting on gastrointestinal tract plus metabolism (37% and cardiovascular drugs (28%. Calcium channel blockers represented the largest antihypertensive drug class (41%. Almost three-fourths of patients received more than one antihypertensive agent. Approximately 37% of patients did not receive any antidiabetic medication. Of those who did, prescriptions for insulin (91% exceeded those of oral hypoglycaemic drugs (9%. Antimicrobials accounted for 10.2% of all drugs prescribed, of which 31.8% were quinolones. Drugs prescribed by generic name accounted for 11.98%. While all patients received antihypertensive therapy, more than a third were not on any antidiabetic treatment. Antihypertensive poly-therapy was observed in the majority with calcium channel blockers being most frequently prescribed antihypertensive drug class. Insulin was the preferred to hypoglycaemic drugs.

  8. Immune regulation in IgA nephropathy

    NARCIS (Netherlands)

    Eijgenraam, Jan-Willem

    2008-01-01

    IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. The hallmark of the disease is depositions of polymeric IgA1 in the mesangium of the glomeuli. These depositions will lead to inflammation in the kidneys and eventually to deterioration of renal function. The pathogenesi

  9. Application of GIS in epizootiological surveillance of swine trichinellosis in one endemic district in Serbia.

    Science.gov (United States)

    Zivojinovic, M; Sofronic-Milosavljevic, L; Radojicic, S; Kulisic, Z

    2010-12-01

    Application of new tools for epizootiological investigations in veterinary medicine, such as Geographical Information Systems (GIS), offers a new approach and possibilities for the eradication or control of infectious diseases. GIS is particularly useful for research conducted in small areas strongly impacted by man. Trichinellosis is a world-wide zoonosis, which is endemic in some European countries, Balkan district and Serbia in particular. There are very few data on GIS application in the field of trichinellosis. We here present the application of GIS for mapping Trichinella spp. occurrence and spatial and temporal patterns of Trichinello infection in one endemic district in Serbia. Settlements with trichinellosis were marked and particular points of interest were designated. Data on prevalence of Trichinella infection in domestic swine accompanied by location of foci indicated the existence of disease geographical stationarity. This first report on GIS application in Serbia will facilitate trichinellosis surveillance and monitoring of Trichinella spp. circulation among domestic pigs, and populations of synanthropic and sylvatic animals.

  10. Trichinella infections in different host species of an endemic district of Serbia.

    Science.gov (United States)

    Zivojinovic, M; Sofronic-Milosavljevic, Lj; Cvetkovic, J; Pozio, E; Interisano, M; Plavsic, B; Radojicic, S; Kulisic, Z

    2013-05-20

    Trichinella infections are endemic in the Balkan region of Europe. Though trichinellosis and agents thereof are serious problems for human health and animal husbandry, only a limited number of Trichinella isolates from Serbia have been identified at the species level so far. The aim of the present study was the surveillance and monitoring of Trichinella in domestic pigs and wild animals from the endemic district of Branicevo. Investigations performed during the 2009-2010 period revealed Trichinella infections in 344 out of 282,960 (0.12%) domestic pigs. Among wildlife, Trichinella infections were detected in 11 out of 94 (11.7%) wild boars (Sus scrofa), 7 out of 57 (12.3%) red foxes (Vulpes vulpes), 7 out of 13 (53.8%) golden jackals (Canis aureus), and in all three examined wolves (Canis lupus). Trichinella spiralis and Trichinella britovi were the only two species identified. T. britovi was identified in 31% of isolates from wildlife of the Branicevo district and T. spiralis was found in 53% of wild animals; mixed infections were observed in 16% of the animals examined. Findings form the basis of an information campaign for veterinary services, pig owners and the hunter's associations about the risk of the transmission of these zoonotic agents. The application of control programs as established at the Veterinary Specialist Institute of Pozarevac resulted in a decline in Trichinella infections among domestic pigs and the absence of human trichinellosis in the last three years in the Branicevo district.

  11. Tracing the Mediterranean climate influence over the central Balkans (southeast Europe) during the past 350 ka

    Science.gov (United States)

    Obreht, Igor; Zeeden, Christian; Hambach, Ulrich; Veres, Daniel; Marković, Slobodan; Boesken, Janina; Bačević, Nikola; Gavrilov, Milivoj; Lehmkuhl, Frank

    2016-04-01

    Knowledge of past climate variability based on the study of paleoclimate archives may help in better understanding the forcing mechanisms and extent of any future climate change. In some regions, such as Eastern Europe, loess-paleosol sequences (LPS) are one of the most important terrestrial archives of Quaternary paleoclimate and its spatial and temporal dynamics. Studies of LPS from the Middle and Lower Danube basins fundamentally improved understanding of the European Quaternary climate and environmental evolution. The central Balkans (central Serbia) is situated in a transition zone between the temperate-continental climate zone to the north and Mediterranean climate to the south. Up to now this area has been poorly investigated concerning the paleoclimate evolution on a longer term, albeit this region is considered more sensitive to the relative influence associated to the Mediterranean climate influence than the Carpathian basin further north. To fill this gap we conducted a high-resolution multiproxy investigation on the Stalać LPS in the central Balkan (Serbia). Located at the southern limits of European loess distribution and within the Mediterranean climate influence, the Stalać section has potential for better understanding of past regional climate dynamics. We discuss grain-size (granulometric fractions, U-ratio), environmental magnetic (χ, χfd), geochemical (major and trace elements) and colour (L*, a*, b* values) data from the Stalać section in terms of switching sediment provenance sources modulated by past environmental conditions. We can show that the Carpathian Basin and central Balkans were influenced by different environmental conditions during past ~350 ka. A general higher continentality of the climate during the late Pleistocene can be observed over the Stalać section and the Carpathian Basin, indicating that this trend is more than a regional feature. Our results indicate warmer and/or more humid last glacial cycles compared to

  12. Le conflit franco-italien dans les Balkans 1915-1935.: Le rôle de la Yougoslavie

    Directory of Open Access Journals (Sweden)

    Pavlović Vojislav

    2005-01-01

    Full Text Available The conflict between France and Italy in the Balkans in fact was an attempt at reorganizing the Balkans and Central Europe following the disappearance of the Habsburg and Romanoff. The two Latin powers now had a unique opportunity to dictate a rearrangement of the Balkans, but their positions were diametrically opposed. Italy sought to establish domination in the Adriatic and the Balkans, whereas France sought to reorganize the region with the view to precluding Germany from recovering its former influence. At the same time, after Wilson’s political defeat in the Senate in 1919 Italian guarantees of the French-German border became vitally important to France. A compromise between Paris and Rome turned out to be unfeasible for several reasons. Expansionism of both the last liberal governments and Mussolini met with resolute opposition from Belgrade. Moreover, Paris was convinced that Italian domination not only would not bring stability to the Balkans, but on the contrary, that it would shatter the region’s Little Entente-based inner cohesion and facilitate Germany’s comeback. Thus most of diplomatic initiatives coming from Paris and Rome were mutually neutralized while German economic influence in the region irresistibly grew from the early 1930s. The agreement Mussolini-Laval reconciled the two Latin powers but it was now in the new circumstances created by the rise of Nazi Germany as a dominant force in Central Europe and the Balkans.

  13. Standing at the gateway to Europe--the genetic structure of Western balkan populations based on autosomal and haploid markers.

    Science.gov (United States)

    Kovacevic, Lejla; Tambets, Kristiina; Ilumäe, Anne-Mai; Kushniarevich, Alena; Yunusbayev, Bayazit; Solnik, Anu; Bego, Tamer; Primorac, Dragan; Skaro, Vedrana; Leskovac, Andreja; Jakovski, Zlatko; Drobnic, Katja; Tolk, Helle-Viivi; Kovacevic, Sandra; Rudan, Pavao; Metspalu, Ene; Marjanovic, Damir

    2014-01-01

    Contemporary inhabitants of the Balkan Peninsula belong to several ethnic groups of diverse cultural background. In this study, three ethnic groups from Bosnia and Herzegovina - Bosniacs, Bosnian Croats and Bosnian Serbs - as well as the populations of Serbians, Croatians, Macedonians from the former Yugoslav Republic of Macedonia, Montenegrins and Kosovars have been characterized for the genetic variation of 660 000 genome-wide autosomal single nucleotide polymorphisms and for haploid markers. New autosomal data of the 70 individuals together with previously published data of 20 individuals from the populations of the Western Balkan region in a context of 695 samples of global range have been analysed. Comparison of the variation data of autosomal and haploid lineages of the studied Western Balkan populations reveals a concordance of the data in both sets and the genetic uniformity of the studied populations, especially of Western South-Slavic speakers. The genetic variation of Western Balkan populations reveals the continuity between the Middle East and Europe via the Balkan region and supports the scenario that one of the major routes of ancient gene flows and admixture went through the Balkan Peninsula.

  14. CARPATHIANS ENDEMIC TAXA IN ARGEŞ COUNTY

    Directory of Open Access Journals (Sweden)

    Valeriu Alexiu

    2013-12-01

    Full Text Available Endemic plant species are the biogeographic elements why use the delimitation of biogeographical regions. Their presence explains, in the context of identifying phyto-historical factors, distribution of species and certain distribution patterns. Endemic areas, with pronounced as the basic unit of biogeography, indicates those particular geographic region, both in the growth areas and the evolutionary biological processes of speciation.In this study we proposed the following objectives: knowing the list Carpathian endemic species and endemic centers present in Argeş, also, areas of endemism in the Carpathians Mountains of the Argeş County.

  15. Brain’s DNA Repair Response to Neurotoxicants

    Science.gov (United States)

    2005-07-01

    Gordon WA, Cantor JB (2004) The diagnosis of cognitive impairment associated with exposure to mold. Adv Appl Microbiol 55:361-374. Gordon WA...investigated (see review Marquardt and Frohlich, 1992). OTA has been shown to induce a tubulointerstitial nephropathy in animals (Krogh et al., 1974...and enzymuria (Kane et al., 1986a,b) similar to Balkan endemic nephropathy found in humans (Krogh, 1992; Krogh et al., 1974; Petkova-Bocharova et al

  16. The Balkan beam - Florschütz frame and its use during the Great War.

    Science.gov (United States)

    Fatović-Ferenčić, Stella; Pećina, Marko

    2014-10-01

    We remember the military medical practice of Croatian surgeon, Vatroslav Florschütz (1879-1967), known for his invention of the traction frame for repositioning bone fracture fragments of the upper and lower extremities. The method, known as the Balkan frame / beam or Balkan splint, was introduced and published in 1911 and used in war medicine thereafter. The memory of this invention adds to our orthopaedic heritage and sheds light on its creator working under the most demanding war circumstances. On the occasion of the 100th anniversary of the outbreak of World War I, reminiscence of Florschütz's war experience, his orthopaedic innovation and other innovations contributes to our understanding of human efforts to save lives and restore bodily function of the wounded during wars.

  17. Envenoming following bites by the Balkan adder Vipera berus bosniensis - first documented case series from Bulgaria.

    Science.gov (United States)

    Westerström, Alexander; Petrov, Boyan; Tzankov, Nikolay

    2010-12-01

    We report the first detailed accounts of bites by the Balkan adder, Vipera berus bosniensis from Bulgaria. Documentation of bites by this subspecies is very rare in the literature and most available accounts are from the northern limit of its distribution. V. berus bosniensis is considered to possess neurotoxic venom but little evidence has hitherto been available to support this supposition. In this case series symptoms typical of adder bites developed including oedema, nausea, dizziness, lymphangitis, vomiting, and diarrhoea together with aberrant symptoms such as diplopia and ptosis that confirm the presence of neurotoxic venom in Balkan adders. In addition, unusual and atypical symptoms of adder bites such as painless bites and muscle cramps appeared. The inadequate treatment in hospital and the remote habitats in which this species is encountered are potential sources of complication.

  18. Health technology assessment in the Balkans: opportunities for a balanced drug assessment system.

    Science.gov (United States)

    Dankó, Dávid; Petrova, Guenka

    2014-11-02

    Countries in the Balkan region use pharmaco-economic data for decisions about the inclusion of new pharmaceuticals into their positive drug lists, but no predefined frameworks are used and resources for health technology assessment (HTA) are limited. The goal of this analysis is to investigate into possible development directions for the HTA system in the region, and provide some practical recommendations for a sustainable model. For this purpose, the main factors currently influencing HTA in Balkan countries are briefly presented, and possible development strategies are compared. A resource-saving balanced assessment approach is proposed. It is aligned with available resources and capabilities, and helps access to new pharmaceuticals while ensuring the transparency of decision-making processes and the stability of the pharmaceutical budget.

  19. 1st International Symposium and 10th Balkan Conference on Operational Research

    CERN Document Server

    Sifaleras, Angelo; Georgiadis, Christos; Papathanasiou, Jason; Stiakakis, Emmanuil

    2013-01-01

    Over the past two decades, the Balkan Conference on Operational Research (BALCOR) has facilitated the exchange of scientific and technical information on the subject of Operations Research and related fields such as Mathematical Programming, Game Theory, Multiple Criteria Decision Analysis, Information Systems, Data Mining, and more, in order to promote international scientific cooperation.  The contributed papers contained in this volume consist of 25 selected research papers based on results presented at the 10th Balkan Conference & 1st International Symposium on Operational Research in Thessalonike, Greece. Subjects include, but do not restrict to, the development of theory and mathematical models for Operations Research, theory and applications of Combinatorial Optimization, Supply Chain Optimization, and Military Operations Research.  These carefully selected papers present important recent developments and modern applications, and will serve as excellent reference for students, researchers, and pr...

  20. The Romanian Schools and Churches in Balkan Peninsula. 1864-1948. Archives Documents

    Directory of Open Access Journals (Sweden)

    Adina Berciu-Drăghicescu

    2006-01-01

    Full Text Available The present article on Romanian schools and churches, in the Balkan Peninsula, over the period 1918-1948 is based on the unprecedented documents identified in the funds preserved in the Diplomatic Archives of the Ministry of Foreign Affairs and in the Central Historic National Archives in Bucharest. The author has studied and selected the unprecedented documents that had the most important significance for the purpose of presenting the evolution of the school and churche situation of the Romanian communities situated at the south of the Danube, starting from year 1864, when the first school was established in Tarnova, (Macedonia and up to 1948 when the Romanian state abandoned the work unveiled by ruler Al. Ioan Cuza. The article presents this situation, very dramatic, of the Romanian communities from the Balkans based on the documents of Archives.

  1. Genetic structure and demographic history of brown trout ( Salmo trutta ) populations from the southern Balkans

    DEFF Research Database (Denmark)

    Apostolidis, A.P.; Madeira, M.J.; Hansen, Michael Møller

    2008-01-01

    1. The present study was designed to characterize the genetic structure of brown trout (Salmo trutta) populations from the southern Balkans and to assess the spread of non-native strains and their introgression into native trout gene pools. We analysed polymorphism at nine microsatellite loci in ...... compromised. Therefore, appropriate management and conservation strategies should be developed urgently in order to protect the subspecific biodiversity and to reverse currently negative trends....

  2. Tettigonia balcanica, a new species from the Balkan Peninsula (Orthoptera, Tettigoniidae

    Directory of Open Access Journals (Sweden)

    D.P. Chobanov

    2014-10-01

    Full Text Available Tettigonia balcanica, sp. n., discovered in the mountainous regions of the Central, Western and North Balkan Peninsula, is described in this paper. This species has many similarities with T. silana and T. cantans. However, it differs by the song and some morphological characters. Its range differs from that of T. cantans, with which it has been confused so far, but the border between their ranges has yet to be specified.

  3. IMPACT ON GLOBALIZATION TREND OF MOVEMENT OF EXTERNAL DEBT IN THE WESTERN BALKANS

    Directory of Open Access Journals (Sweden)

    JELENA TOSKOVIC

    2016-12-01

    Full Text Available Globalization is seen as a process of transformation of regional phenomena into global and represents the interdependence of world society with the operation of the remote locations. It is considered the main vehicle for the implementation of neo-liberal concept of economy that is in the Western Balkans, its implementation began in the early nineties of the XX century. The Western Balkans is its geographical position was the boundaries between cultures, religions, nations and states. Throughout history, the political turmoil in this region has been a major conflicts, which affected the economic policies of the countries and the region. In this way, the region lost balance as reflected in the decrease in the volume of trade and increased borrowing mainly from international financial institutions. The growth of debt resulted in the increase in external debt (public and private sectors, which led to an imbalance in economic development and macroeconomic stability in the society. The aim of the paper is to determine to what extent the process of globalization has led to an increase / influence on increasing trend of foreign debt in the countries of the Western Balkans (Albania, Bosnia and Herzegovina, FYR Macedonia, Montenegro and Serbia in the period 2004-2014. years. The work is in addition to the introduction consists of three parts. The first analyzes the problem of growth of external debt, the second analyzes the trend of the external debt of the private and public sector, while the third analyzes the current account balance and economic growth in the Western Balkans. In addition, at the end of the data concluding observations.

  4. Book review: Macedonia: the political, social, economic and cultural foundations of a Balkan state

    OpenAIRE

    Knight, Daniel Martyn

    2013-01-01

    Macedonia: The Political, Social, Economic and Cultural Foundations of a Balkan State is a collection of twelve essays taking an in-depth look at the multi-layered relationships between different groups in Macedonia from an anthropological perspective. Daniel M. Knight finds the book to offer revealing insights into the rich tapestry of life in modern-day Macedonia, especially in the areas of religion and ethnicity.

  5. Labour Market Institutions in the Western Balkan Countries and their Economic Implications: Evidence for Kosova

    Directory of Open Access Journals (Sweden)

    MSc. Anera Alishani

    2013-12-01

    To address this issue, this paper provides a literature review of the notion of flexicurity and then investigates the relevance of flexicurity for the countries of the Western Balkans through its found components (flexible and reliable contractual arrangements, lifelong learning, active employment policies and social security system. Even though flexicurity can be a way out for low performed economies it is considered as highly costly.

  6. Deep drilling of ancient Lake Ohrid (Balkan region) to capture over 1 million years of evolution and global climate cycling

    Science.gov (United States)

    Wagner, Bernd; Francke, Alexander; Wilke, Thomas; Krastel, Sebastian; Zanchetta, Giovanni; Sulpizio, Roberto; Reicherter, Klaus; Leng, Melanie; Grazhdani, Andon; Trajanovski, Sasho; Levkov, Zlatko; Reed, Jane; Wonik, Thomas

    2014-05-01

    Ancient lakes, with sediment records spanning >1 million years, are very rare. The UNESCO World Heritage site of Lake Ohrid in the Balkan region is thought to be the oldest lake in continuous existence in Europe and, with 212 endemic species described to date, is a hotspot of evolution. An international group of scientists working on a project entitled 'Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO)' realized a deep drilling campaign of Lake Ohrid in spring 2013. Based on several coring seismic campaigns between 2004 and 2011, Lake Ohrid became the target of an ICDP deep drilling campaign, with specific research aims: (i) obtain precise information about the age and origin of the lake, (ii) unravel the lake's seismotectonic history, (iii) obtain a continuous record of Quaternary volcanic activity and climate change, and (iv) investigate the influence of major geological/environmental events on evolution and the generation of extraordinary endemic biodiversity. Drilling began in April 2013 using the Deep Lake Drilling System (DLDS) of DOSECC (USA). The campaign, completed by late May, was deemed one of the most successful ICDP lake drilling projects, with a total of ~2100 m of sediment recovered from four different sites. At the central "DEEP" site, hydro-acoustic data indicated a maximum sediment fill of ca. 700 m, of which the uppermost 568 m was recovered. Coarse gravel and pebbles underlying clay and shallow water facies hampered deeper penetration. A total of 1526 m of sediment cores was collected from six boreholes, with a composite field recovery ('master core') of 544 m (95%). Three additional sites were drilled in order to analyze lake-level fluctuations, catchment dynamics, biodiversity and evolution processes ("Cerava", deepest drilled depth: 90 m), to investigate active tectonics and spring dynamics ("Gradiste", deepest drilled depth: 123 m), and to try to understand the geological origins of the Ohrid Basin ("Pestani

  7. Net capital flows to and the real exchange rate of Western Balkan countries

    Directory of Open Access Journals (Sweden)

    Gabrisch Hubert

    2015-01-01

    Full Text Available This paper uses Granger causality tests to assess the linkages between changes in the real exchange rate and net capital inflows using the example of Western Balkan countries, which have suffered from low competitiveness and external imbalances for many years. The real exchange rate is a measure of a country’s price competitiveness, and the paper uses two concepts: relative unit labour cost and relative inflation differential. The sample consists of six Western Balkan countries for the period 1996-2012, relative to the European Union (EU. The main finding is that changes in the net capital flows precede changes in relative unit labour costs and not vice versa. Also, there is evidence that net capital flows affect the inflation differential of countries, although to a less discernible extent. This suggests that the increasing divergence in the unit labour cost between the EU and Western Balkan countries up to the global financial crisis was at least partly the result of net capital inflows. The paper adds to the ongoing debate on improving cost competitiveness through wage restrictions as the main vehicle to avert the accumulation of current account imbalances. It shows the importance of changes in the exchange rate regime, reform of the interaction between the financial and the real sector, and financial supervision and structural change.

  8. Energy in the western Balkans - the path to reform and reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    The Western Balkans - composed of Albania, Bosnia and Herzegovina, Croatia, the Former Yugoslav Republic of Macedonia, Montenegro, Serbia and Kosovo - is a complex region facing significant energy challenges. The conflicts over the break-up of the former Yugoslavia damaged much of the energy infrastructure and compounded the challenge of providing reliable energy supply. Electricity systems in many parts of the region remain fragile and in need of investment. A priority across the region is to put into place the institutions, infrastructure and policies that can support the provision of reliable, affordable and sustainable energy. For the Western Balkans as a whole, a key element of the reform effort is the Energy Community Treaty - a regulatory and market framework to which the entire region has now subscribed. This Treaty aims to create an integrated regional market for electricity and gas compatible with the European Union's internal energy market. This Energy Policy Survey is the first comprehensive review of energy policies and strategies in the Western Balkan region, and also covers important cross-cutting topics such as co-operation and energy trade, oil and gas transportation, and the links between energy and poverty. It identifies and assesses the reforms that are still needed to deliver efficient, modernised energy systems that can assist economic development, address energy poverty and reduce the environmental impacts of energy use.

  9. Agricultural Support: Consequences of the Eventual Accession of the Balkan Countries to the Europe Union

    Directory of Open Access Journals (Sweden)

    Sándor Richter

    2008-06-01

    Full Text Available The author estimates the potential impact of the accession of seven Balkan countries (Albania, Croatia, Bosnia and Herzegovina, Macedonia, Montenegro, Serbia and Turkey to the EU on the agricultural direct payments and rural development expenditures disbursed from the EU budget. The estimation is based on the assumption that the agricultural support to GDP ratios are similar across member states at similar levels of development sharing a similar weight of agriculture in the economy. The results show that the annual additional burden for the 27 current EU members due to a Balkan enlargement would range between EUR 5 and 11.5 billion (in 2004 prices. The former figure reflects an agricultural support to GDP ratio corresponding to the average of the 12 new member states; the latter reflects the respective (average ratio of Bulgaria and Romania. In relative terms the Balkan enlargement would necessitate a net increase of the pool of transfers for direct payments and rural development expenditures in the range of 10% to 23%.

  10. A Balkan-style French revolution?: The 1804 Serbian Uprising in European perspective

    Directory of Open Access Journals (Sweden)

    Bataković Dušan T.

    2005-01-01

    Full Text Available The Serbian uprising of 1804-13, initially a peasant rebellion against abuses of power by local janissaries, turned into a national and social revolution from 1806. During its second phase (late 1806 - early 1807, Serbian insurgents openly proclaimed their demand for independence. Encouraged by their military achievements, the insurgent leaders began to seek wider Balkan support for their struggle against Ottoman domination. Although its political claims were a mixture of modern national and romantic historic rights, the uprising gave hope to all Balkan Christians that the Ottoman defeat was an achievable goal. For the Balkan nations it was a French Revolution adapted to local conditions: the principle of popular sovereignty was opposed to the principle of legitimism; a new peasant-dominated society was created in which, due to the lack of the aristocracy and well-established middle classes, agrarian egalitarianism was combined with the rising aspirations of a modern nation. Its long-term effects on the political and social landscape of the whole region justified the assessment of the eminent German historian Leopold von Ranke who described the uprising, by analogy with the French example, as the Serbian Revolution.

  11. THE WESTERN BALKANS BETWEEN INTERNAL TRANSITIONS AND THE EU INTEGRATION PROCESS

    Directory of Open Access Journals (Sweden)

    Elira LULI

    2015-12-01

    Full Text Available The Balkan region is still a “hot” zone where old legacies of the past interfere with the present and contribute to the transition processes of the countries there. The region seems committed to follow an EU-bound path, although it faces many challenges in terms of meeting the standards for EU and NATO membership. Somehow, persistent conflicts delay finding solutions. The difficult democratic transition, the lack of will and shallow political culture of regional elites delay the process of bringing these countries forward. This profound transition unfortunately occurs while the EU, on one hand, is trying to play the arbitrator part having promised to assume full leadership role and, on the other hand, tries to restrain the voices of those Euro-Sceptics who have been increasing their numbers recently. Meanwhile, a deterioration of the situation in the Balkans might have a negative impact across Europe and decrease the credibility of the EU as the main foreign policy and security actor in the whole region. This paper will first analyse the transition processes in the Balkans and the back and forth efforts to leave behind the past and head toward a common European perspective. Secondly, it will analyse the required active role of the EU and the urgency for a closer monitoring of the situation in this region. Thirdly, it emphasises the need to encourage public diplomacy in the region in order to mitigate conflicts and promote cooperation between the people there.

  12. STANDING IN - BETWEEN: ELEMENTS OF BALKAN IDENTITY UNDERLYING ROMANIA’S POSITION IN THE EU

    Directory of Open Access Journals (Sweden)

    GABRIELA DUMBRAVĂ

    2014-12-01

    Full Text Available The paper examines the decisive impact of Romania’s Balkan heritage on its current position in the EU. Our study aims at proving that Romania’s present status among the EU countries is not only a matter of perception from the outside, but also a matter of self – perception, both being shaped by the stereotypes pertaining to the concept of ‘Balkanism’. Historically torn between the East and the West, the central and the liminal, the local and the global, the Balkan area has fostered a unique awareness of national identity, supported by a suspicious and defensive attitude towards the ‘outside’ and totally incongruent with the idea of integration. During the past years, the tension between its Balkan heritage and the integrative EU policies has generated a sense of identity crisis, due to which the Romanians find themselves “concomitantly inside and outside, actors in and audience at a play; owing to this ambiguity, they neither perform, nor watch very well”.

  13. The determinants of intra-regional trade in the Western Balkans

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    Jelena Trivić

    2015-06-01

    Full Text Available The purpose of this paper is to identify factors that have an influence on bilateral trade among the Western Balkan countries for the period from 1995 to 2012. Unlike a majority of works that have dealt with the subject of trade in the Balkans or the SEEs, not only geographical, economic or political factors are taken into account, but also factors constituting cultural, communicational and historical types of the so-called “distance” between countries. In order to assess their influence on trade values, an augmented version of the gravity model is employed. It was estimated threefold: as pooled data by OLS, as a random effects model and as a fixed effects model with an additional estimation of time-invariant variables following the method of Cheng and Wall (2005. The results of the research are surprising, as the strongest influence on trade values were exhibited by variables representing ease of a direct communication and similarity of religious structures. In addition, war and one-year-post-war effect showed a strong and statistically important influence. Thus, the main conclusion is that non-economic factors in the region of the Western Balkans play the most important role in determining trade values between countries.

  14. Orientalism, Balkanism and the Western Viewpoint in the Context of Former Yugoslavia

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    MA. Atdhe Hetemi

    2015-06-01

    Full Text Available This research paper examines the role of the Orientalist and Balkanist discourse in the Former Yugoslavia with a particular focus on Albanians. Here, Western Orientalist and Balkanist stereotypes of the Former Yugoslavia are examined arguing that the Orientalism and Balkanism of people living in the Former Yugoslavia is and was viewed differently from the standard by the West and by the people living in the Former Yugoslavia in the way how they perceive each other. The first part of this research paper treats the Orientalism and Balkanism in the context of people living in the Former Yugoslavia, in general. The second part of this research paper analyzes the case study of the application of the Orientalist and Balkanist theoretical lenses on one of the nations living in the Former Yugoslavia, namely Albanians. Here, some explorations and thoughts are provided on how Albanians define themselves and how they were perceived by the South Slavic majority living in the Former Yugoslavia. There are three authors and, subsequently, three seminal works that shall serve as pillars of this theoretical analysis: concepts of Edward Said’s “Orientalism,” Bakic-Hayden’s theories on Orientalist variations and nesting Orientalism, and Maria Todorova’s ground-breaking analysis of the external practices of Balkans representation. These provide a useful theoretical framework through which to explore the distribution of the Orientalist and Balkanist discourses in Former Yugoslavia.

  15. The Balkan balneotherapy product – an approach from the destination marketing perspective

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    Aurelia-Felicia STĂNCIOIU

    2013-10-01

    Full Text Available Considering the common features in the resources field, but especially the way in which they have been managed at the level of each individual country, it can be stated that a destination such as the Balkan peninsula represents a culturally homogeneous space, which has been crystallized over centuries of common history and which has imprinted a “common” destiny to the member countries, regarding the economic and cultural development. Regarding natural resources, the main similarity resides in the existence of balneotherapy resources, with particular therapeutic properties, nowadays’ development being pressured by the deterioration of one’s conception about its own health (from the demand perspective, on the one hand, and extending the concept of health (from the supply perspective, on the other hand. In the context of a less-controlled development of certain methods/techniques/procedures by the stakeholders of wellness industry, it is necessary to maintain the authenticity of the balneotherapy product whose essence is the treatment. The purpose of the paper relies in establishing the common elements which could form the essence of the balneotherapy product (sui generis and, in the same time, the differentiation elements which form the developed product of each Balkan country, alongside with the establishment of joint actions, in order to set the coordinates of the regional balneotherapy marketing strategy for the Balkan peninsula.

  16. Reduced Expression of Lipoic Acid Synthase Accelerates Diabetic Nephropathy

    OpenAIRE

    Yi, Xianwen; Xu, Longquan; Hiller, Sylvia; Kim, Hyung-Suk; Nickeleit, Volker; James, Leighton R; Maeda, Nobuyo

    2011-01-01

    Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic acid abrogates diabetic nephropathy in animal models, but whether lower production of endogenous lipoic acid promotes diabetic nephropathy is unknown. Here, we crossed mice heterozygous for lipoic ...

  17. Smoking and progression of diabetic nephropathy in type 1 diabetes

    DEFF Research Database (Denmark)

    Hovind, Peter; Rossing, Peter; Tarnow, Lise

    2003-01-01

    OBJECTIVE: Cigarette smoking contributes to development of diabetic nephropathy. However, long-term studies on the effect of smoking on decline in kidney function in diabetic nephropathy are lacking. We assessed the impact of smoking on progression of diabetic nephropathy in type 1 diabetic...... patients enrolled in a prospective observational cohort study started in 1983. RESEARCH DESIGN AND METHODS: We identified all albuminuric type 1 diabetic patients (n = 301) followed for at least 3 years, median (range) 7 years (3-14), who underwent at least yearly measurement of glomerular filtration rate...... was not associated with decline in kidney function in type 1 diabetic patients with diabetic nephropathy....

  18. Classification and Differential Diagnosis of Diabetic Nephropathy

    Science.gov (United States)

    2017-01-01

    Diabetic nephropathy (DN) is a major cause of end-stage renal disease throughout the world in both developed and developing countries. This review briefly introduces the characteristic pathological changes of DN and Tervaert pathological classification, which divides DN into four classifications according to glomerular lesions, along with a separate scoring system for tubular, interstitial, and vascular lesions. Given the heterogeneity of the renal lesions and the complex mechanism underlying diabetic nephropathy, Tervaert classification has both significance and controversies in the guidance of diagnosis and prognosis. Applications and evaluations using Tervaert classification and indications for renal biopsy are summarized in this review according to recent studies. Meanwhile, differential diagnosis with another nodular glomerulopathy and the situation that a typical DN superimposed with a nondiabetic renal disease (NDRD) are discussed and concluded in this review. PMID:28316995

  19. Classification and Differential Diagnosis of Diabetic Nephropathy

    Directory of Open Access Journals (Sweden)

    Chenyang Qi

    2017-01-01

    Full Text Available Diabetic nephropathy (DN is a major cause of end-stage renal disease throughout the world in both developed and developing countries. This review briefly introduces the characteristic pathological changes of DN and Tervaert pathological classification, which divides DN into four classifications according to glomerular lesions, along with a separate scoring system for tubular, interstitial, and vascular lesions. Given the heterogeneity of the renal lesions and the complex mechanism underlying diabetic nephropathy, Tervaert classification has both significance and controversies in the guidance of diagnosis and prognosis. Applications and evaluations using Tervaert classification and indications for renal biopsy are summarized in this review according to recent studies. Meanwhile, differential diagnosis with another nodular glomerulopathy and the situation that a typical DN superimposed with a nondiabetic renal disease (NDRD are discussed and concluded in this review.

  20. Diabetic Nephropathy : Evaluation with Doppler Ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Jung Suk; Kim, Seung Hyup; Kang, Heung Sik; Park, Jae Hyung; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1996-06-15

    To compare Doppler ultrasonography with laboratory tests in evaluation of diabetic nephropathy. Fifty-five patients (mean age = 60, M : F = 26 : 29) with diabetes mellitus underwent renal Doppler ultrasonography. Resistive indices were compared with degree of proteinuria, serum creatinine level, and creatinine clearance rate. Eighteen patients who showed no proteinuria or microscopic proteinuria had a mean resistive index (RI) of 0.72 (SD, 0.05), 16 patients with macroscopic proteinuria without nephrotic syndrome had a mean RI of 0.82 (SD, 0.13), and 21 patients with nephrotic syndrome had a mean RI of 0.90 (SD, 0.12). Renal RI correlated highly with serum creatinine level (r = 0.62) and creatinine clearance rate (r = -0.43). Renal Doppler ultrasonography provides a useful indication of renal function in diabetic nephropathy but cannot offer an advantage over conventional laboratory test

  1. Renoprotective effects of losartan in diabetic nephropathy

    DEFF Research Database (Denmark)

    Andersen, Steen; Tarnow, Lise; Cambien, Francois

    2002-01-01

    evaluated the short-term renoprotective effect in diabetic nephropathy of the angiotensin II receptor antagonist losartan in patients homozygous for the insertion or the deletion allele. METHODS: Fifty-four hypertensive type 1 diabetic patients with diabetic nephropathy homozygous for the insertion (I; N......BACKGROUND: The beneficial short- and long-term renoprotective effects of angiotensin I-converting enzyme (ACE) inhibition are lower in albuminuric diabetic patients homozygous for the deletion compared to the insertion polymorphism of the ACE gene. In an attempt to overcome this interaction, we...... = 26) or the deletion (D; N = 28) allele of the ACE/ID polymorphism were included. After four weeks of washout, the patients received losartan 50 mg daily followed by 100 mg in two treatment periods each lasting two months. Patients and investigators were blinded to ACE genotypes. At baseline...

  2. Diabetic nephropathy in Surinamese South Asian subjects

    OpenAIRE

    Chandieshaw, Prataap Kalap; Chandie Shaw, Prataap Kalap

    2008-01-01

    This thesis focuses on the incidence and risk factors for nephropathy in diabetic and non-diabetic Surinamese South Asians. The Surinamese South Asians, originally descended from the North-East India. Due to the former colonial bounds with the Netherlands, a relatively young South Asian migrant population settled in the Netherlands. South Asians have a high prevalence of central obesity and an eight-fold higher prevalence for type 2 diabetes mellitus. We found the following conclusions: 1.Sur...

  3. Diabetic nephropathy – complications and treatment

    OpenAIRE

    Lim AK

    2014-01-01

    Andy KH Lim1–3 1Department of Nephrology, Monash Medical Center, Monash Health, 2Department of General Medicine, Dandenong Hospital, Monash Health, 3Department of Medicine, Monash University, Clayton, VIC, Australia Abstract: Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal failure globally. Much research has been conducted in both basic science and clinical therapeutics, which has enhanced understanding of the pathophysiology of diabetic ne...

  4. Histological changes of kidney in diabetic nephropathy.

    Science.gov (United States)

    Pourghasem, Mohsen; Shafi, Hamid; Babazadeh, Zahra

    2015-01-01

    Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectable 2 years after diabetes is diagnosed. The glomerular alterations are the most important lesions in the diabetic nephropathy (DN). The Renal Pathology Society provides a new pathological classification for the detection of histopathology of DN. It divides diabetic nephropathy into four hierarchical glomerular lesions. Alloxan or streptozotocin induced diabetic rat is the one most widely used specie to study DN. Histological changes in the rat DN closely resemble the human disease and the most information of this review was obtained through the study of rat DN. All cell types of the kidney such as mesangial cells, podocytes and tubulointerstitial cells are liable to be affected in the event of DN. Severity of renal lesions is associated to the clinical aspect of renal outcome, but the aim of this article was only to review the histological changes of kidney in diabetes mellitus.

  5. Medical and Social Aspects of Syphilis in the Balkans from the mid-19th Century to the Interwar.

    Science.gov (United States)

    Tsiamis, Costas; Vrioni, Georgia; Poulakou-Rebelakou, Effie; Gennimata, Vasiliki; Murdjeva, Mariana А; Tsakris, Athanasios

    2016-03-01

    The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia), urbanization, poverty and the frequent wars have been considered the major factors conducive to the spread of syphilis. The measures against sex work and sexually transmitted diseases (STDs) were taken in two aspects, one medical and the other legislative. In this period, numerous hospitals for venereal diseases were established in the Balkan countries. In line with the international diagnostic approach and therapeutic standards, laboratory examinations in these Balkan hospitals included spirochete examination, Wassermann reaction, precipitation reaction and cerebrospinal fluid examination. Despite the strict legislation and the adoption of relevant laws against illegal sex work, public health services were unable to curb the spread of syphilis. Medical and social factors such as poverty, citizen's ignorance of STDs, misguided medical perceptions, lack of sanitary control of prostitution and epidemiological studies, are highlighted in this study. These factors were the major causes that helped syphilis spread in the Balkan countries during the 19th and early 20th century. The value of these aspects as a historic paradigm is diachronic. Failure to comply with the laws and the dysfunction of public services during periods of war or socioeconomic crises are both factors facilitating the spread of STDs.

  6. Medical and Social Aspects of Syphilis in the Balkans from the mid-19th Century to the Interwar

    Directory of Open Access Journals (Sweden)

    Tsiamis Costas

    2016-03-01

    Full Text Available The current study presents some aspects of syphilis in the Balkan Peninsula from the 19th century until the Interwar. Ever since the birth of modern Balkan States (Greece, Bulgaria, Turkey and Serbia, urbanization, poverty and the frequent wars have been considered the major factors conducive to the spread of syphilis. The measures against sex work and sexually transmitted diseases (STDs were taken in two aspects, one medical and the other legislative. In this period, numerous hospitals for venereal diseases were established in the Balkan countries. In line with the international diagnostic approach and therapeutic standards, laboratory examinations in these Balkan hospitals included spirochete examination, Wassermann reaction, precipitation reaction and cerebrospinal fluid examination. Despite the strict legislation and the adoption of relevant laws against illegal sex work, public health services were unable to curb the spread of syphilis. Medical and social factors such as poverty, citizen’s ignorance of STDs, misguided medical perceptions, lack of sanitary control of prostitution and epidemiological studies, are highlighted in this study. These factors were the major causes that helped syphilis spread in the Balkan countries during the 19th and early 20th century. The value of these aspects as a historic paradigm is diachronic. Failure to comply with the laws and the dysfunction of public services during periods of war or socioeconomic crises are both factors facilitating the spread of STDs.

  7. Risk factor control is key in diabetic nephropathy.

    Science.gov (United States)

    Lewis, Gareth; Maxwell, Alexander P

    2014-02-01

    Prolonged duration of diabetes, poor glycaemic control and hypertension are major risk factors for both diabetic nephropathy and cardiovascular disease. Optimising blood sugar control together with excellent control of blood pressure can reduce the risk of developing diabetic nephropathy. Diabetic nephropathy should be considered in any patient with diabetes when persistent albuminuria develops. Microalbuminuria is the earliest clinically detectable indicator of diabetic nephropathy risk. The majority of patients with diabetic nephropathy are appropriately diagnosed based on elevated urinary albumin excretion and/or reduced 0032-6518 renal function. Patients with type 2 diabetes should have annual urinary ACR measurements from the time of diabetes diagnosis while those with type 1 diabetes should commence five years after diagnosis. Blood pressure lowering to 130/80mmHg and reduction of proteinuria to diabetic nephropathy and reduces the number of cardiovascular events. Drugs that block the renin-angiotensin-aldosterone system (RAAS) are effective in reducing proteinuria, managing hypertension and reducing cardiovascular risk. Unless there are clear contraindications or intolerance all patients with diabetic nephropathy should be prescribed an ACEI or ARB. Stopping an ACEI or ARB during intercurrent illness or times of volume depletion is critically important. Patients with diabetic nephropathy should have at least yearly measurements of blood pressure, renal function and urinary ACR.

  8. Generalized Nets for the Diagnosis and Management of Diabetic Nephropathy

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    Anthony Shannon

    2009-10-01

    Full Text Available This paper develops Generalized Nets for the diagnosis and management of diabetic nephropathy. The first net accounts for the development of nephropathy from an initial increase in glomerular filtration rates through mciroalbuminuria to end stage renal disease. The second net referes to the management of diabetes mellitus to increase the probability of preventing diabetic nephropathyor minimising its effects.

  9. Endemism analysis of Neotropical Pentatomidae (Hemiptera, Heteroptera

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    Augusto Ferrari

    2010-12-01

    Full Text Available The definition of areas of endemism is central to studies of historical biogeography, and their interrelationships are fundamental questions. Consistent hypotheses for the evolution of Pentatomidae in the Neotropical region depend on the accuracy of the units employed in the analyses, which in the case of studies of historical biogeography, may be areas of endemism. In this study, the distribution patterns of 222 species, belonging to 14 Pentatomidae (Hemiptera genera, predominantly neotropical, were studied with the Analysis of Endemicity (NDM to identify possible areas of endemism and to correlate them to previously delimited areas. The search by areas of endemism was carried out using grid-cell units of 2.5° and 5° latitude-longitude. The analysis based on groupings of grid-cells of 2.5° of latitude-longitude allowed the identification of 51 areas of endemism, the consensus of these areas resulted in four clusters of grid-cells. The second analysis, with grid-cells units of 5° latitude-longitude, resulted in 109 areas of endemism. The flexible consensus employed resulted in 17 areas of endemism. The analyses were sensitive to the identification of areas of endemism in different scales in the Atlantic Forest. The Amazonian region was identified as a single area in the area of consensus, and its southeastern portion shares elements with the Chacoan and Paraná subregions. The distribution data of the taxa studied, with different units of analysis, did not allow the identification of individual areas of endemism for the Cerrado and Caatinga. The areas of endemism identified here should be seen as primary biogeographic hypotheses.

  10. Improved prognosis of diabetic nephropathy in type 1 diabetes

    DEFF Research Database (Denmark)

    Andrésdóttir, Gudbjörg; Jensen, Majken L; Carstensen, Bendix

    2015-01-01

    -term renin-angiotensin system inhibition), lipids, and glycemia, along with less smoking and other lifestyle and treatment advancements, is inadequately analyzed. To clarify this, we studied 497 patients with type 1 diabetes and diabetic nephropathy at the Steno Diabetes Center and compared them...... and nephropathy onset occurred later in life, mortality was reduced by 30%. Risk factors for decline in glomerular filtration rate, death, and other renal end points were generally in agreement with prior studies. Thus, with current treatment of nephropathy in type 1 diabetes, the prognosis and loss of renal......The natural history of diabetic nephropathy offered an average survival of only 5-7 years. During the past decades, multiple changes in therapy and lifestyle have occurred. The prognosis of diabetic nephropathy after implementing stricter control of blood pressure (including increased use of long...

  11. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy

    OpenAIRE

    Rossini, Michele; Naito, Takashi; Yang, Haichun; Freeman, Michael; Donnert, Ellen; Ma, Li-Jun; Dunn, Stephen R.; Sharma, Kumar; Fogo, Agnes B.

    2010-01-01

    Background. Sulodexide is a glycosaminoglycan with anticoagulant and antithrombotic activities. Although sulodexide reduced albuminuria in patients with type 1 and type 2 diabetes, long-term effects on chronic renal injury are not established. We investigated sulodexide effects and mechanisms in a rat radiation nephropathy model and in the db/db mouse model of diabetic kidney disease.

  12. Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?

    NARCIS (Netherlands)

    Deurwaarder, E.S. den; Steenbergen, E.; Hoogeveen, E.K.; Wetzels, J.F.M.

    2012-01-01

    Originally described as a proliferative glomerulonephritis, C1q nephropathy is nowadays mostly recognized as a variant of focal segmental glomerulosclerosis or minimal change disease. We describe a 30-year-old male patient with nephrotic range proteinuria. Kidney biopsy demonstrated a membranous nep

  13. Mechanisms of diabetic nephropathy--old buddies and newcomers part 2.

    Science.gov (United States)

    Nawroth, P P; Isermann, B

    2010-11-01

    The clinical translation of established pathomechanisms of diabetic nephropathy improved the outcome in patients with diabetic nephropathy. However, they fail to halt or even reverse diabetic nephropathy, even though the feasibility of disease reversal has been established. The second part of this review summarizes recent novel insights into the mechanisms of diabetic nephropathy focusing on novel candidate mechanisms of diabetic nephropathy. These studies emphasize a crucial role of endothelial dependent mechanisms, which, however, can not be viewed as independent determinants of diabetic nephropathy. Rather, the endothelial dependent mechanisms act in concert with other cellular systems, establishing an intra-glomerular cross-talk which determines the progression of diabetic nephropathy.

  14. Rodent models of diabetic nephropathy: their utility and limitations.

    Science.gov (United States)

    Kitada, Munehiro; Ogura, Yoshio; Koya, Daisuke

    2016-01-01

    Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore, novel therapies for the suppression of diabetic nephropathy must be developed. Rodent models are useful for elucidating the pathogenesis of diseases and testing novel therapies, and many type 1 and type 2 diabetic rodent models have been established for the study of diabetes and diabetic complications. Streptozotocin (STZ)-induced diabetic animals are widely used as a model of type 1 diabetes. Akita diabetic mice that have an Ins2+/C96Y mutation and OVE26 mice that overexpress calmodulin in pancreatic β-cells serve as a genetic model of type 1 diabetes. In addition, db/db mice, KK-Ay mice, Zucker diabetic fatty rats, Wistar fatty rats, Otsuka Long-Evans Tokushima Fatty rats and Goto-Kakizaki rats serve as rodent models of type 2 diabetes. An animal model of diabetic nephropathy should exhibit progressive albuminuria and a decrease in renal function, as well as the characteristic histological changes in the glomeruli and the tubulointerstitial lesions that are observed in cases of human diabetic nephropathy. A rodent model that strongly exhibits all these features of human diabetic nephropathy has not yet been developed. However, the currently available rodent models of diabetes can be useful in the study of diabetic nephropathy by increasing our understanding of the features of each diabetic rodent model. Furthermore, the genetic background and strain of each mouse model result in differences in susceptibility to diabetic nephropathy with albuminuria and the development of glomerular and tubulointerstitial lesions. Therefore, the validation of an animal model reproducing human diabetic nephropathy will significantly facilitate our understanding of the underlying genetic mechanisms that contribute to the development of diabetic nephropathy. In this review, we focus on rodent models of diabetes and discuss the utility and limitations of these models for the study of diabetic

  15. The environmental state of rivers in the Balkans--a review within the DPSIR framework.

    Science.gov (United States)

    Skoulikidis, Nikolaos Th

    2009-04-01

    Fifteen major Balkan rivers with over 80% of the inflows in Eastern Mediterranean were examined for their environmental state within the DPSIR framework. Physicogeographic and hydrochemical conditions differ substantially among river basins, which may be roughly classified into three main zones. Despite strong fragmentation, most of the rivers are liable to flash floods and have low summer flow. Decreasing precipitation and (mis)management caused a dramatic discharge reduction over the last decades. Wars, political instability, economical crises over the past decades, combined with administrative and structural constraints, poor environmental planning and inspection and, frequently, a lack of environmental awareness imposed significant pressures on rivers. Large wetland areas were drained in favour of widespread intensive agriculture. The treatment of municipal wastewaters is barely adequate in Greece and insufficient elsewhere, while management and treatment of mining and industrial wastewaters is overall poor. In general, lowland river sections are hydro-morphologically modified and are at the greatest pollution risk, while upstream areas mostly retain their natural conditions. Nutrient concentrations in a number of central and eastern Balkan rivers often exceed quality standards, whereas pesticides and heavy metals, partly of geochemical origin, occasionally exceed quality standards. Reservoirs retain vast masses of sediments, thus adversely affecting delta evolution, while dam operation disturbs the seasonal hydrological and hydrochemical regimes. Almost all Balkan countries face daunting water resource challenges because of urgently needed investments in water supply, sanitation, irrigation, and hydroelectricity. International treaties and designations and European Union Directives have mobilized pollution mitigation and conservation efforts. However, the application of environmental legislation has proved in a number of cases inadequate. Constraints arise

  16. An Examination of Long-Term Environmental-Social Dynamics in the Balkans

    Science.gov (United States)

    Kulkarni, C.; Boger, R. A.

    2015-12-01

    This study examines the interactions of environmental and social dynamics in Central Balkans over the past millennium, a period that experienced three major climatic phases (Medieval Climate Anomaly, Little Ice Age, and the warm 20th century). Meanwhile, the same period witnessed a complex human history with the emergence-rise-decline of the Ottoman Empire and subsequent socio-political events (e.g. wars, famines, migrations). Environmental datasets for the analysis include biological proxies (pollen, spores, and charcoal), geochemical signals through X-ray fluorescence (XRF), and a detailed chronology based on AMS 14C dating of two western and central Serbian lakes while social datasets include historic population data, land use, settlement patterns, and critical historic events derived from a review of the literature and local archives. Among the environmental datasets, indigenous tree and herbaceous pollen from these Central Balkans records demonstrate fluctuations in woodland-grassland dynamics whereas potassium and titanium counts obtained through XRF act as a proxy for surface erosion and clastic input into the lakes. Microscopic charcoal, cereal pollen and subordinate anthropogenic pollen (e.g. cultivated fruits and vegetables) are used to distinguish strong human impact over the landscape. These key anthropogenic indicators create a more thorough social component of the analysis in association with the social datasets. After reconstructing the individual time series for each environmental and social dataset, the two Central Balkan records are correlated in order to identify the environmental and social homogeneity and heterogeneity patterns occurring at shorter and longer timescales during the period. Results provide insights on how a region responds to social and environmental stressors and our approach demonstrates ways to integrate natural and social science system research.

  17. THE EU APPROACH TO THE WESTERN BALKANS: A SECURITY OR POLITICAL ISSUE?

    Directory of Open Access Journals (Sweden)

    Ruth FERERRO-TURRIÓN

    2015-12-01

    Full Text Available This paper will focus on the policies developed by the European Union towards the Western Balkans, especially those related to human mobility and visa liberalization. The main target of the paper will be to show how the conditionality policies towards these countries have been developed related to security, geopolitical needs and interests, instead of the objective/technical criteria stated in the communitarian official documents. We will see how the last enlargements of the Union have affected considerably the different positions adopted by member states in their approach toward the Balkan countries, especially in relation to chapters 23 and 24 of the negotiation agreements, dealing with issues of Justice and Home Affairs. Since then, the pragmatic approach of the Union has been reinforced, so that the accession of candidates has been delayed in time. However, some things might change, if we take into consideration the current refugee and Ukraine crises, the new relationships that have been developed with Russia (especially by Serbia, and Greece’s approach towards Moscow on the verge of the economic crisis. If the European Union has, until now, followed a stick-and-carrot approach towards the Balkans in order to maintain a security belt on its southeast border, this approach might change within a new geopolitical context. In this paper we will analyse the visa liberalization process and its developments since Thessaloniki 2003, to show how the decisions taken by the Union have been more linked to political matters related to security than to technical reasons related to passport design.

  18. Social complexity and inequality in the Late Neolithic of the Central Balkans: reviewing the evidence

    Directory of Open Access Journals (Sweden)

    Marko Porčić

    2012-12-01

    Full Text Available The aim of this paper is to review and critically evaluate relevant archaeological evidence regarding recent claims about the social complexity of Late Neolithic societies in the Central Balkans. Theory suggests that the relevant evidence should be related to population size, economic intensification, ranking, and craft specialisation. It is concluded that, although there are indications that inequalities existed and also demographic potential for organisational complexity, there is no unambiguous evidence that institutionalised inequality in the form of complex polities such as chiefdoms or states ever developed.

  19. Influence of climatic changes on pollution levels in the Balkan Peninsula

    DEFF Research Database (Denmark)

    Zlatev, Z.; Georgiev, K.; Dimov, I.

    2013-01-01

    The aim of the paper is to study the influence of future climatic changes on some high pollution levels that can cause damages on plants, animals and human beings. The particular area of interest is the Balkan Peninsula. Four important quantities have been selected: (a) annual concentrations, (b...... of these scenarios, are carefully studied. The major conclusion is that the increase of the temperature, alone or in combination with some other factors, leads to rather considerable increases of some pollution levels, which might become dangerous for the environment. © 2012 Elsevier Ltd. All rights reserved....

  20. Transnational Solidarity Networks and the Transformations of a Crisis : the Balkan Crisis of 1875-1878

    OpenAIRE

    Egner, Wolfgang

    2015-01-01

    If we look at the Greek budget crisis today, we can see how an economic crisis changed into a political one for the whole EU. This is just a brief example how crises and especially their public perception transform themselves in various ways. The Balkan Crisis of 1875-1878 is an exceptional example for the variability of crises. It shows how the change of people’s perception of a crisis can modify expressions of solidarity, which in turn transforms the phenomenon of crisis itself. published

  1. Tres publicaciones recientes sobre Lope de Aguirre: Galster, Aguilar y Córdoba, y Balkan

    Directory of Open Access Journals (Sweden)

    Carlos Páramo Bonilla

    2012-07-01

    Full Text Available Ingrid Galster. Aguirre o la posteridad arbitraria. Bogotá: Universidad del Rosario-Pontificia Universidad Javeriana, 2011. Traducción de Oscar Sola. 844 páginas.Diego de Aguilar y Córdoba. El Marañón [1578]. Madrid-Frankfurt: Universidad de Navarra-Iberoamericana-Vervuert, 2011. 423 páginas.Evan L. Balkan. The Wrath of God: Lope de Aguirre, Revolutionary of the Americas Albuquerque: University of New Mexico Press, 2011. 225 páginas.

  2. Serbian-Albanian language contacts and two types of phonological systems in the Balkan languages

    Directory of Open Access Journals (Sweden)

    Stanišić Vanja S.

    2003-01-01

    Full Text Available Phonological systems of the Balkan languages do not correspond to the Balkan language union borders, which can be explained by the difference between "intensive" (morphosyntactic and "extensive" (phonological language unions. In this case, we are dealing with the entrance of the Balkan languages into a wide transitional zone, stretching along the borders of East and Central Europe, and with the coinciding of their phonological systems with the system of Slavic languages known as vowel and consonant types. The same classification into two phonological systems exists in the Balkans too, and between them there are also two transitional borderlines. As known, the mediopalatal order of the "Macedonian" type [k', g', n', ľ] (q, gj, nj, l has been generalized in both the standard Albanian language and most of the Albanian dialects. Albanian [k', g', n', ľ] are, just like their Macedonian counterparts, semi-emancipated palatal correlates of basic [k, g, n, l], as proved by examples of their positional dephonologization and dialectal hardening /n'/ > /n/ [n%], when followed by front vowels. Both semi-soft [n%] and typically Albanian lateral opposition [ł-ŀ] confirm a palatal correlation of these phonemes existing also in the neighboring Serbian dialects. Albanian has undoubtedly affected the rise of these features, be it through an unilateral influence or merely through supporting different phonological development in these old-shtokavian dialects. On the other hand, the same could be said for the affrication of palatovelars [k', g'] > [č, ʒ(], which except in south-west region between Ishmi and Shkumbin, Elbasan and Tirana is present in all other branches of the Ghegian dialect. Wide distribution of this phenomenon excludes the possibility of one-sided Serbian influence while its character – reduction of palatovelars [k', g'] (q, gj and affricates [č, ʒ(] (ç, xh to one semi-soft affricate pair – has a typological and structural parallel in

  3. Luo Lingjie's Experience in Treating Chronic Nephropathy

    Institute of Scientific and Technical Information of China (English)

    Cai Min; Yang Yonghe; Luo Lingjie; Duan Shumin

    2008-01-01

    @@ In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.

  4. Gold nephropathy in juvenile rheumatoid arthritis.

    Science.gov (United States)

    Husserl, F E; Shuler, S E

    1979-01-01

    A 2-year-old girl was treated with gold salts for juvenile rheumatoid arthritis. Treatment had to be discontinued when persistent proteinuria was detected. As this case report indicates, close monitoring of the urine is mandatory during treatment with gold salts to detect early signs of toxicity: hematuria followed by casts and then proteinuria as therapy is continued. Histologic examination with electron microscopy will help to differentiate the different forms of gold toxicity. When the findings are consistent with gold-induced renal involvement, therapy should be discontinued. The gold nephropathy usually resolves in time, with no permanent renal damage.

  5. [Schistosomiasis endemic in Burkina Faso].

    Science.gov (United States)

    Poda, J N; Traoré, A; Sondo, B K

    2004-02-01

    Burkina Faso, through the works of many teams of the OCCGE based in Bobo-Dioulasso, has signi-ficant data on several tropical endemics of which schistosomiasis. With the complementary works, it appears to be possible to establish a distribution of the schistosomiasis which reveals its importance. It will be the first stage of the planned national control program. The parasitologic data-gathering which covers the period of 1951 to 2000, used all the standard techniques. It is about Kato-Kartz and MIF for the intestinal schistosomiasis, centrifugation, filtration, serology reagent strips, macroscopy of urines and echography of the urinary system for the urinary schistosomiasis. All the eleven medical areas of the country have many sites submitted to parasitologic investigation. As regard the distribution of the two parasites involved with man (Schistosoma haematobium and S. mansoni), the data of prevalence (1% to 100%) and their distribution confirm their endemicity and the focal transmission. S. mansoni is located in eight medical areas particularly in the South and the West. S. haematobium is present in all the eleven medical areas of the country. In hydraulic planning as Sourou where the prevalences went from 23% to 70% for S. haematobium and from 0% to 69% for S. mansoni between 1987 and 1998. The situation requires a continuous monitoring. The spatial distribution of the six species of intermediate hosts shows that Bulinus truncatus and B. senegalensis Soudano-Sahelian species are present in all the ecological zones. B. globosus and Biomphalaria pfeifferi meet preferentially in the southern half of the country which reinforces the observation according to which the 14th northern parallel is often considered as the limit of septentrional extension of these two species. The other species Bulinus forskalii and B umbilicatus could have preference areas. All the species show a certain affinity with a type of biotope. The rarity and temporary aquatic systems lead to a

  6. Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy.

    Science.gov (United States)

    Abouzed, Tarek Kamal; Munesue, Seiichi; Harashima, Ai; Masuo, Yusuke; Kato, Yukio; Khailo, Khaled; Yamamoto, Hiroshi; Yamamoto, Yasuhiko

    2016-01-01

    Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. Methods. Male mice overexpressing inducible nitric oxide synthase in pancreatic β-cells were employed as a diabetic model. Salicylate (3 g/kg diet) or pyridoxamine (1 g/L drinking water; ~200 mg/kg/day) was given for 16 weeks to assess the development of diabetic nephropathy. Treatment with long-acting insulin (Levemir 2 units/kg twice a day) was used as a control. Results. Although higher blood glucose levels were not significantly affected by pyridoxamine, early to late stage indices of nephropathy were attenuated, including kidney enlargement, albuminuria, and increased serum creatinine, glomerulosclerosis, and inflammatory and profibrotic gene expressions. Salicylate showed beneficial effects on diabetic nephropathy similar to those of pyridoxamine, which include lowering blood glucose levels and inhibiting macrophage infiltration into the kidneys. Attenuation of macrophage infiltration into the kidneys and upregulation of antiglycating enzyme glyoxalase 1 gene expression were found only in the salicylate treatment group. Conclusions. Treatment with salicylate and pyridoxamine could prevent the development of diabetic nephropathy in mice and, therefore, would be a potentially useful therapeutic strategy against kidney problems in patients with diabetes.

  7. Reversal of diabetic nephropathy by a ketogenic diet.

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    Michal M Poplawski

    Full Text Available Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged elevation of 3-OHB, may reverse pathological processes caused by diabetes. To address this hypothesis, we assessed if prolonged maintenance on a ketogenic diet would reverse nephropathy produced by diabetes. In mouse models for both Type 1 (Akita and Type 2 (db/db diabetes, diabetic nephropathy (as indicated by albuminuria was allowed to develop, then half the mice were switched to a ketogenic diet. After 8 weeks on the diet, mice were sacrificed to assess gene expression and histology. Diabetic nephropathy, as indicated by albumin/creatinine ratios as well as expression of stress-induced genes, was completely reversed by 2 months maintenance on a ketogenic diet. However, histological evidence of nephropathy was only partly reversed. These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined.

  8. BMP-7 PROTEIN EXPRESSION IS DOWNREGULATED IN HUMAN DIABETIC NEPHROPATHY.

    Science.gov (United States)

    Ivanac-Janković, Renata; Ćorić, Marijana; Furić-Čunko, Vesna; Lovičić, Vesna; Bašić-Jukić, Nikolina; Kes, Petar

    2015-06-01

    Bone morphogenetic protein-7 (BMP-7) is expressed in all parts of the normal kidney parenchyma, being highest in the epithelium of proximal tubules. It protects kidney against acute and chronic injury, inflammation and fibrosis. Diabetic nephropathy is the leading cause of chronic kidney disease, and is characterized by decreased expression of BMP-7. The aim of our study was to analyze whether the expression of BMP-7 is significantly changed in advanced stages of human diabetic nephropathy. Immunohistochemical analysis of the expression of BMP-7 was performed on archival material of 30 patients that underwent renal biopsy and had confirmed diagnosis of diabetic nephropathy. Results showed that BMP-7 was differently expressed in the cytoplasm of epithelial cells of proximal tubules and podocytes among all stages of diabetic nephropathy. At early stages of diabetic nephropathy, BMP-7 was strongly positive in proximal tubules and podocytes, while low expression was recorded in the majority of samples at advanced stages. In conclusion, increased expression of BMP-7 at initial stages of diabetic nephropathy with subsequent decrease at advanced stage highlights the role of BMP-7 in the protection of kidney structure and function. Further investigations should be focused on disturbances of BMP-7 receptors and signaling pathways in patients with diabetic nephropathy.

  9. Diabetic Nephropathy: New Risk Factors and Improvements in Diagnosis.

    Science.gov (United States)

    Tziomalos, Konstantinos; Athyros, Vasilios G

    2015-01-01

    Diabetic nephropathy is the leading cause of end-stage renal disease. Patients with diabetic nephropathy have a high cardiovascular risk, comparable to patients with coronary heart disease. Accordingly, identification and management of risk factors for diabetic nephropathy as well as timely diagnosis and prompt management of the condition are of paramount importance for effective treatment. A variety of risk factors promotes the development and progression of diabetic nephropathy, including elevated glucose levels, long duration of diabetes, high blood pressure, obesity, and dyslipidemia. Most of these risk factors are modifiable by antidiabetic, antihypertensive, or lipid-lowering treatment and lifestyle changes. Others such as genetic factors or advanced age cannot be modified. Therefore, the rigorous management of the modifiable risk factors is essential for preventing and delaying the decline in renal function. Early diagnosis of diabetic nephropathy is another essential component in the management of diabetes and its complications such as nephropathy. New markers may allow earlier diagnosis of this common and serious complication, but further studies are needed to clarify their additive predictive value, and to define their cost-benefit ratio. This article reviews the most important risk factors in the development and progression of diabetic nephropathy and summarizes recent developments in the diagnosis of this disease.

  10. Constant diversification rates of endemic gastropods in ancient Lake Ohrid: ecosystem resilience likely buffers environmental fluctuations

    Science.gov (United States)

    Föller, K.; Stelbrink, B.; Hauffe, T.; Albrecht, C.; Wilke, T.

    2015-12-01

    Ancient lakes represent key ecosystems for endemic freshwater species. This high endemic biodiversity has been shown to be mainly the result of intra-lacustrine diversification. Whereas the principle role of this mode of diversification is generally acknowledged, actual diversification rates in ancient lakes remain little understood. At least four types are conceivable. Diversification rates may be constant over time, they may fluctuate, rates may be higher in the initial phase of diversification, or there may be a pronounced lag phase between colonization and subsequent diversification. As understanding the tempo of diversification in ancient lake environments may help reveal the underlying processes that drive speciation and extinction, we here use the Balkan Lake Ohrid as a model system and the largest species flock in the lake, the non-pyrgulinid Hydrobiidae, as a model taxon to study changes in diversification rates over time together with the respective drivers. Based on phylogenetic, molecular-clock, lineage-through-time plot, and diversification-rate analyses we found that this potentially monophyletic group is comparatively old and that it most likely evolved with a constant diversification rate. Preliminary data of the SCOPSCO (Scientific Collaboration On Past Speciation Conditions in Lake Ohrid) deep-drilling program do indicate signatures of severe environmental/climatic perturbations in Lake Ohrid. However, so far there is no evidence for the occurrence of catastrophic environmental events. We therefore propose that the constant diversification rate observed in endemic gastropods has been caused by two factors: (i) a potential lack of catastrophic environmental events in Lake Ohrid and/or (ii) a probably high ecosystem resilience, buffering environmental changes. Parameters potentially contributing to the lake's high ecosystem resilience are its distinct bathymetry, ongoing tectonic activities, and karst hydrology. The current study not only

  11. Constant diversification rates of endemic gastropods in ancient Lake Ohrid: ecosystem resilience likely buffers environmental fluctuations

    Directory of Open Access Journals (Sweden)

    K. Föller

    2015-08-01

    Full Text Available Ancient lakes represent key ecosystems for endemic freshwater species. This high endemic biodiversity has been shown to be mainly the result of intra-lacustrine diversification. Whereas the principle role of this mode of diversification is generally acknowledged, actual diversification rates in ancient lakes remain little understood. At least four modes are conceivable. Diversification rates may be constant over time, they may fluctuate, rates may be higher in the initial phase of diversification, or there may be a pronounced lag phase between colonization and subsequent diversification. As understanding the tempo of diversification in ancient lake environments may help unrevealing the underlying processes that drive speciation and extinction, we here use the Balkan Lake Ohrid as a model system and the largest species flock in the lake, the non-pyrgulinid Hydrobiidae, as a model taxon to study changes in diversification rates over time together with the respective drivers. Based on phylogenetic, molecular-clock, lineage-through-time plot and diversification-rate analyses we found that this monophyletic group is comparatively old and that it most likely evolved with a constant diversification rate. Preliminary data of the SCOPSCO deep-drilling program do indicate signatures of severe environmental/climatic perturbations in Lake Ohrid. However, so far there is no evidence for the occurrence of catastrophic environmental events. We therefore propose that the rate homogeneity observed in endemic gastropods has been caused by two factors: (i a potential lack of catastrophic environmental events in Lake Ohrid and/or (ii a high ecosystem resilience, buffering environmental changes. Parameters potentially contributing to the lake's high ecosystem resilience are its distinct bathymetry, ongoing tectonic activities, and karst hydrology. The current study not only contributes to one of the overall goals of the SCOPSCO deep-drilling program – inferring

  12. Smoking in diabetic nephropathy: sparks in the fuel tank?

    Science.gov (United States)

    Chakkarwar, Vishal Arvind

    2012-12-15

    Diabetic nephropathy is associated with high morbidity and mortality and the prevalence of this disease is continuously increasing worldwide. Long-term diabetes increases the likelihood of developing secondary complications like nephropathy, the most common cause of end stage renal disease. Usually, other factors like hypertension, alcoholism and smoking also partly contribute to the progression of diabetic nephropathy. Among this, cigarette smoking in diabetes has been repeatedly confirmed as an independent risk factor for the onset and progression of diabetic nephropathy. Various studies suggest that smoking is a major fuel in the development of high oxidative stress and subsequently hyperlipidemia, accumulation of advanced glycation end products, activation of the renin angiotensin system and Rho-kinase, which are observed to play a pathogenic role in the progression of diabetic nephropathy. Furthermore, cigarette smoking in diabetic patients with vascular complications produces a variety of pathological changes in the kidney, such as thickening of the glomerular basement membrane and mesangial expansion with progression in glomerulosclerosis and interstitial fibrosis, which ultimately results in end stage renal failure. Strong associations are consistently found between chronic cigarette smoking and diabetic microvascular complications. A diverse group of studies unveil potential mechanisms that may explain the role of cigarette smoking in the progression of diabetic nephropathy. Tremendous efforts are being made to control smoking mediated progression of diabetic nephropathy, but no promising therapy is yet available. The present review critically discusses the possible detrimental role of chronic cigarette smoking in the progression of diabetic nephropathy and various possible pharmacological interventions to attenuate the exacerbation of diabetic nephropathy.

  13. Management of nephropathy in patients with type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Purpose To review evidence-based management of nephropathy in patients with type 2 diabetes. Data sources A literature search (MEDLINE 1966 to 2000) was performed using the key word “diabetic nephropathy". Relevant book chapters were also reviewed. Study selection Well-controlled, prospective landmark studies and expert review articles on diabetic nephropathy were selected. Data extraction Data and conclusions from the selected articles that provide solid evidence to the optimal management of diabetic nephropathy were extracted and interpreted in light of our clinical research experience with many thousands of Hong Kong Chinese patients. Results Hypertension, long diabetes duration, poor glycaemic control and central obesity are the most important risk factors. Microalbuminuria is a practical marker to predict overt nephropathy in type 2 diabetic patients. Risk factor modification, renal function monitoring and combined therapies are the current integrated approaches to manage patients with diabetic kidney disease. Optimal glycaemic control is the mainstay of treatment but effective antihypertensive therapy is also key to delaying the progression of diabetic nephropathy. Angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor antagonists have important renoprotective actions independent of their blood pressure lowering actions. Conclusions Diabetic nephropathy is the leading cause of end-stage renal disease worldwide. Monitoring renal function and screening for microalbuminuria will allow the identification of patients with nephropathy at a very early stage for intervention. Tight glycaemic control and aggressive antihypertensive treatment as well as the use of renin-angiotensin system inhibitors should substantially delay the progression of nephropathy.

  14. Environmental Monitoring of Endemic Cholera

    Science.gov (United States)

    ElNemr, W.; Jutla, A. S.; Constantin de Magny, G.; Hasan, N. A.; Islam, M.; Sack, R.; Huq, A.; Hashem, F.; Colwell, R.

    2012-12-01

    Cholera remains a major public health threat. Since Vibrio cholerae, the causative agent of the disease, is autochthonous to riverine, estuarine, and coastal waters, it is unlikely the bacteria can be eradicated from its natural habitat. Prediction of disease, in conjunction with preventive vaccination can reduce the prevalence rate of a disease. Understanding the influence of environmental parameters on growth and proliferation of bacteria is an essential first step in developing prediction methods for outbreaks. Large scale geophysical variables, such as SST and coastal chlorophyll, are often associated with conditions favoring growth of V. cholerae. However, local environmental factors, meaning biological activity in ponds from where the bulk of populations in endemic regions derive water for daily usage, are either neglected or oversimplified. Using data collected from several sites in two geographically distinct locations in South Asia, we have identified critical local environmental factors associated with cholera outbreak. Of 18 environmental variables monitored for water sources in Mathbaria (a coastal site near the Bay of Bengal) and Bakergonj (an inland site) of Bangladesh, water depth and chlorophyll were found to be important factors associated with initiation of cholera outbreaks. Cholera in coastal regions appears to be related to intrusion. However, monsoonal flooding creates conditions for cholera epidemics in inland regions. This may be one of the first attempts to relate in-situ environmental observations with cholera. We anticipate that it will be useful for further development of prediction models in the resource constrained regions.

  15. Beginning of the metal age in the central Balkans according to the results of the archeometallurgy

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    Jovanović B.

    2009-01-01

    Full Text Available The gradual development of the primary copper metallurgy in Balkans starts with production of small jewelry pieces and ends with the serial production of massive tools and weapons. It is confirmed that this metallurgy depended on the contemporary mining, i.e. the available sources of the raw materials. It is also corroborated by the discovery of two Early Eneolithic copper mines: Rudna Glava in Eastern Serbia and Ai-Bunar in Bulgaria /first half and the middle of the 5th millennium BC/. These mines are also the evidence for the local exploitation of the carbonate copper minerals - malachite and azurite. The technology employed is close to the former flint mining in the Late Neolithic; massive pebbles obtained from the neighboring alluvial deposits were used as mining hammers. Identical technology was employed in the mines dating from the later periods /Rudnik, Central Serbia, Jarmovac, Priboj na Limu/. The Vinča culture of the central Balkan followed all metallurgical phases of introduction of metal and use of the carbonate ores /Gradac I - III phase/. This long process of including the metal in wider use lasted generally from the middle of the 5th millennium BC to the end of the 4th millennium BC, i.e. to the appearance of the Bronze Age.

  16. Embryonic glaciers on the Balkan peninsula: state and changes in the last several years

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    Emil GACHEV

    2014-11-01

    Full Text Available Mountain glaciers are among the best natural indicators of short-term climatic variations. Although presently there are no classical glaciers on the Balkan peninsula, mountains in this part of Europe comprise a number of small but permanent firn-ice patches, which can be categorized as embryonic glaciers. They are subdivided into: typical glacierets (most of them and small glaciers (a hybrid form between glacierets and cirque glaciers. Most of these features have survived the warming since the end of the Little Ice Age, and are considered to have persisted for at least five centuries without a complete melt (Grunewald et al., 2008; Gachev, Stoyanov, 2013.Researches in the last several years (Milivojević et al.. 2008; Hughes, 2007, 2009; Djurović, 2009, 2012; Gachev et al., 2009 and others revealed the presence of embryonic glaciers in just three mountain ranges throughout the Balkan peninsula: Prokletije mountains (in Albania, Durmitor (in Montenegro and Pirin (in Bulgaria (fig. 1. They are all located in north and northeast facing strongly shaded cirque bottoms of carbonate bedrock (limestone, marble at altitudes from 2035 to 2620 m a. s. l., and usually have areas from less than 1 ha to 5 - 6 ha.  

  17. Using Natural Sciences for Cultural Expansion: The National Socialist Agenda for the Balkans

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    Maria Zarifi

    2008-11-01

    Full Text Available This article highlights the political merit natural sciences were awarded under the totalitarian regime of Nazi Germany and their propagandistic role in Hitler's foreign policy agenda for the Balkans, a region which was expected to replace Germany's colonies lost in World War I. It accounts further for the policies and strategies National Socialists used to exert cultural influence on the countries of South-East Europe, namely through a number of institutions with which natural sciences were in one way or another involved in order to promote German culture abroad. The promotion of the German language and, to a certain degree, the Nazi ideology was a precondition for familiarising the Balkan countries with German scientific achievements, which would pave the way for an economic and political infiltration in that region. Therefore, natural sciences, as part of the German intellect, acquired political and economic connotations hidden behind the euphemistic term of cultural policy, designed for this region of geopolitical importance. The article is based almost exclusively on unpublished German records.  

  18. Physical self-concept of adolescents in Western Balkan countries: a pilot study.

    Science.gov (United States)

    Janić, Snežana Radisavljević; Jurak, Gregor; Milanović, Ivana; Lazarević, Dušanka; Kovač, Marjeta; Novak, Dario

    2014-10-01

    The aim of this study was to explore physical self-concept of adolescents of the Western Balkans (Serbia, Slovenia, Croatia, and Bosnia and Herzegovina) according to sex and country. The participants were 2,606 students, ages 13 and 14 years (M = 13.5, SD = 0.9). The Physical Self-Description Questionnaire (PSDQ) was used to assess multidimensional physical self-concept. The results show the interaction of sex and country for three dimensions of physical self-concept (Appearance, Global Physical Self-Concept, and Self-Esteem). It was shown that female and male adolescents' perception of physical appearance, self-esteem, and global physical self-concept is more susceptible to influences of socio-cultural factors in the monitored countries. In all other dimensions of Physical self-concept, sex differences were consistently manifested in favour of male adolescents, except in Flexibility. Regardless of adolescents' sex, under the increasing influence of Western culture in the Western Balkan countries, adolescents more critically evaluate their body and motor abilities.

  19. Biomarkers in diabetic nephropathy: Present and future

    Institute of Scientific and Technical Information of China (English)

    Gemma; Currie; Gerard; Mc; Kay; Christian; Delles

    2014-01-01

    Diabetic nephropathy(DN) is the leading cause of end stage renal disease in the Western world. Microalbuminuria(MA) is the earliest and most commonly used clinical index of DN and is independently associated with cardiovascular risk in diabetic patients. Although MA remains an essential tool for risk stratification and monitoring disease progression in DN, a number of factors have called into question its predictive power. Originally thought to be predictive of future overt DN in 80% of patients, we now know that only around 30% of microalbuminuric patients progress to overt nephropathy after 10 years of follow up. In addition, advanced structural alterations in the glomerular basement membrane may already have occurred by the time MA is clinically detectable.Evidence in recent years suggests that a significant proportion of patients with MA can revert to normoalbuminuria and the concept of nonalbuminuric DN is well-documented, reflecting the fact that patients with diabetes can demonstrate a reduction in glomerular filtration rate without progressing from normo-to MA. There is an unmet clinical need to identify biomarkers with potential for earlier diagnosis and risk stratification in DN and recent developments inthis field will be the focus of this review article.

  20. A REVIEW ON DIABETIC NEUROPATHY AND NEPHROPATHY

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    Mohd. Muneer Ahamed

    2012-01-01

    Full Text Available Diabetes is a major public health problem. Diabetes mellitus now affects large number of people in many developing countries than western countries where only two or three percent of the population is affected. With on estimated 33 million people in India alone affected by diabetes. It is a major epidemic of the twentieth century. Diabetes is a chronic disorder, which is associated with obesity, hypertension, advancing age, accumulation of harmful agents in the vascular endothelium causing development of microangiopathies or micro vascular complications. These complications include peripheral neuropathy, nephropathy and retinopathy, which cause early death and increased morbidity. These complications vary in prevalence in different populations depending on various factors such as genetic predisposition and ethnicity. Besides these complications cardiovascular changes are also occurring. Peripheral neuropathy (PN is characterized by pain, numbness, and tingling in the extremities with slow nerve conduction. Up to 50% of all patients with diabetes develop neuropathy and the prevalence of painful neuropathy ranges from 10 to 20% of patients with diabetes. Diabetic nephropathy is characterized by increased urinary protein, loss of renal function, excessive deposition of extracellular matrix proteins in the mesangium, and clear cytoplasm of the proximal tubular epithelial cells due to excessive reabsorbed glycogen. Evaluation of diabetes and its complications is very essential for proper control and prevention of the disease associated complications.

  1. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

    OpenAIRE

    Miranda-Díaz, Alejandra Guillermina; Pazarín-Villaseñor, Leonardo; Yanowsky-Escatell, Francisco Gerardo; Andrade-Sierra, Jorge

    2016-01-01

    The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30–300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60–89 mL/min/1.73 m2), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is 300 mg/day. Chronic kidney disea...

  2. Long-term renoprotective effects of losartan in diabetic nephropathy

    DEFF Research Database (Denmark)

    Andersen, S.; Tarnow, Lise; Cambien, F.

    2003-01-01

    139/74 mmHg (14/8) in both genotype groups during the study (P treatment with losartan has similar beneficial renoprotective effects on progression of diabetic nephropathy in hypertensive...... of the angiotensin II subtype-1 (AT1) receptor antagonist losartan (100 mg o.d.) on kidney function in II and DD type 1 diabetic patients with diabetic nephropathy. RESEARCH DESIGN AND METHODS: A total of 54 hypertensive type 1 diabetic patients with diabetic nephropathy homozygous for the insertion (n = 26...... type 1 diabetic patients with ACE II and DD genotypes....

  3. Relationship between E-cadherin and diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    姜洪娟

    2014-01-01

    Objective To identify novel biomarker for diabetic nephropathy(DN)by urinary proteomic methods,and to detect the expression of E-cadherin in urine and renal tissue of patients with DN.Methods Urine samples were collected from 12 cases of type 1 diabetic nephropathy patients(T1DN),12 cases of type 2 diabetic nephropathy patients(T2DN),12 cases of nephritic syndrome patients(NS),and 12 cases of healthy Controls.Comparative proteomic approach of two-dimensional gel electro-

  4. Balkan Ülkelerinin Anayasalarında Dil Kullanımı İle İlgili Düzenlemeler The Regulation As For Language Usage In The Constitutions Of Balkan States

    Directory of Open Access Journals (Sweden)

    Bilgehan Atsız GÖKDAĞ

    2012-12-01

    Full Text Available One of the regions of interest for multiculturalism andmultilingualism is the Balkans in southeastern Europe. Region includesGreece, Bulgaria, Albania, Romania, on the European side of Turkey asindependent states that emerged after the collapse of Yugoslavia,Macedonia, Croatia, Slovenia, Bosnia-Herzegovina, Kosovo, Serbia andMontenegro. System ruled by the Communist countries of the regionuntil 1990, except for Greece. The breakup of Yugoslavia and theemergence of new states created new constitutions. The constitution ofcountries which multi-ethnic and multi-lingual include freedom oflanguage use.Status of local languages in countries with ethnic diversity isalways a problem for the standard and established. Nations as a resultof partnerships formed by a long common law without nationalassociations is an important question how to solve this problem.Encountered this situation in many countries of the world, how theBalkan countries were effected. Especially in the Balkan region containsmany ethnic groups and languages. This is the most importantdeterminant of geography, religion, ethnic identity, then, has been thelanguage. The world's most well-known linguistic regions of the BalkanPeninsula. Ethnic diversity in the region from time to time in history,religion, and language differences have been exploited by some statesand using these features to their own interests, these countries incitedthe people of the region. This article examined the constitutions of theBalkan countries respond to the needs of its neighborhoods given instandard language, as well as other languages will be investigated.Some of these population groups, there are now in a minority in theirregions and countries are demanding the right language. However, thelanguage policies vary from country to country. For example, the formerYugoslavia, in time, many languages spoken in the country have legalequality, established new states constitutions created a special place forthe

  5. Deliverable 5.2 Study report on consumer motivations and behaviours for fruits and fruit products in the Balkans

    NARCIS (Netherlands)

    Sijtsema, S.J.; Snoek, H.M.

    2010-01-01

    It is unclear whether fruit consumption in Western Balkan countries (WBC) meets recommended levels from a health perspective. A better understanding consumers' perception of health and motives and barriers of fruit is necessary to get insight in the fruit consumption. The aim of WP 5 is therefore to

  6. Security Culture in Times of War: How Did the Balkan War Affect the Security Cultures in Germany and United States?

    Science.gov (United States)

    2007-06-01

    ethnische ‚engineering‘,“ in: Der Jugoslawien-Krieg Handbuch zu Vorgeschichte: Verlauf und Konsequenzen, edited by Melcic, 418. 80 Slavenka Drakulic ...337-66. Cambridge, MA: MIT Press, 2001. Drakulic , Slavenka. “Women Hide Behind a Wall of Silence.” In Why Bosnia? Writings on the Balkan War, edited

  7. Dearth of Early Education Experience: A Significant Barrier to Educational and Social Inclusion in the Western Balkans

    Science.gov (United States)

    Milovanovic, Suncica Macura; Kokic, Ivana Batarelo; Kristiansen, Selma Džemidžic; Gera, Ibolya; Ikonomi, Estevan; Kafedžic, Lejla; Milic, Tamara; Rexhaj, Xhavit; Spasovski, Ognen; Closs, Alison

    2014-01-01

    The article summarises the socio-political, cultural, economic and educational background to the Western Balkans region and outlines the wider qualitative research study that provided the data on early and pre-school educational opportunities in the seven countries involved; Albania, Bosnia and Herzegovina, Croatia, Kosovo (under United Nations…

  8. Les Turcs dans les chansons des Rroms des Balkans à l'époque ottomane The Turks in the Rromani songs in the Balkans during the Ottoman period

    Directory of Open Access Journals (Sweden)

    Marcel Courthiade

    2012-05-01

    Full Text Available La publication bilingue de 11 chansons rromanies de Bulgarie et une de Roumanie, une étude des noms, locutions, expressions turques utilisées dans les chants Rroms illustre la vision rromanie du personnage du Turc. En raison de l'accès tardif des Rroms à la littérature écrite (après la Seconde Guerre mondiale dans les Balkans, il n'y a que les récits oraux qui puissent apporter du matériel pour illustrer la recherche sur tel ou tel personnage dans leur vision du monde. Après avoir expliqué les différents noms attribués aux Turcs dans les chansons populaires, cette présentation tente de définir les traits principaux de ce personnage tel qu'il se dégage de ces chansons, à savoir, impitoyable, féroce et même sadique quand il s'agit de jouer avec la vie et les souffrances de ses victimes. Des points de vue similaires se retrouvent également dans les chansons rromanies de Roumanie. Une partie de cet article est consacrée aux noms propres turcs utilisés par les Rroms et une autre aux expressions et locutions turques présentes dans les chansons. L'étude englobe l'édition bilingue de onze chansons rromanies de Bulgarie et une de Roumanie, dans lesquelles est dépeint le personnage du Turc.Due to the late access of Rromani to written literature (after WWII in the Balkan, only oral accounts can provide illustrative material for research about such and such character in Rromani cosmovision. This is true among others for the Rroms' views on the Turks' character.  After explaining the various names given to the Turks in Rromani folk songs, the presentation attempts to define the main features of this character, as mirrored in these songs: mercilessness, fierceness, even sadism in playing with their victim's life and sufferings. Similar views are encountered in Rromani folk songs from Rumania as well. A passage of the article is devoted to Turkish proper names used among Rroms and another to Turkish phrases and expressions embodied

  9. Autophagy as a Therapeutic Target in Diabetic Nephropathy

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    Yuki Tanaka

    2012-01-01

    Full Text Available Diabetic nephropathy is a serious complication of diabetes mellitus, and its prevalence has been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic target to prevent diabetic nephropathy. Autophagy is a major catabolic pathway involved in degrading and recycling macromolecules and damaged organelles to maintain intracellular homeostasis. The study of autophagy in mammalian systems is advancing rapidly and has revealed that it is involved in the pathogenesis of various metabolic or age-related diseases. The functional role of autophagy in the kidneys is also currently under intense investigation although, until recently, evidence showing the involvement of autophagy in the pathogenesis of diabetic nephropathy has been limited. We provide a systematic review of autophagy and discuss the therapeutic potential of autophagy in diabetic nephropathy to help future investigations in this field.

  10. Rodent models of diabetic nephropathy: their utility and limitations

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    Kitada M

    2016-11-01

    Full Text Available Munehiro Kitada,1,2 Yoshio Ogura,2 Daisuke Koya1,2 1Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, 2Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan Abstract: Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore, novel therapies for the suppression of diabetic nephropathy must be developed. Rodent models are useful for elucidating the pathogenesis of diseases and testing novel therapies, and many type 1 and type 2 diabetic rodent models have been established for the study of diabetes and diabetic complications. Streptozotocin (STZ-induced diabetic animals are widely used as a model of type 1 diabetes. Akita diabetic mice that have an Ins2+/C96Y mutation and OVE26 mice that overexpress calmodulin in pancreatic β-cells serve as a genetic model of type 1 diabetes. In addition, db/db mice, KK-Ay mice, Zucker diabetic fatty rats, Wistar fatty rats, Otsuka Long-Evans Tokushima Fatty rats and Goto-Kakizaki rats serve as rodent models of type 2 diabetes. An animal model of diabetic nephropathy should exhibit progressive albuminuria and a decrease in renal function, as well as the characteristic histological changes in the glomeruli and the tubulointerstitial lesions that are observed in cases of human diabetic nephropathy. A rodent model that strongly exhibits all these features of human diabetic nephropathy has not yet been developed. However, the currently available rodent models of diabetes can be useful in the study of diabetic nephropathy by increasing our understanding of the features of each diabetic rodent model. Furthermore, the genetic background and strain of each mouse model result in differences in susceptibility to diabetic nephropathy with albuminuria and the development of glomerular and tubulointerstitial lesions. Therefore, the validation of an animal model reproducing human diabetic nephropathy will

  11. Telmisartan in the management of diabetic nephropathy: a contemporary view.

    Science.gov (United States)

    Balakumar, Pitchai; Bishnoi, Harish K; Mahadevan, Nanjaian

    2012-05-01

    Diabetic nephropathy, a complex disorder with heterogeneous etiologies, remains one of the most threatening diseases worldwide. There were around 177 million people with diabetes mellitus worldwide, and it has been estimated to be increased to 360 million by 2030. Given that about 20-30% of these people develop diabetic nephropathy, the present treatment protocols primarily aim for an efficient glucose and blood pressure control to arrest the initiation and progression of diabetic nephropathy. The treatment of diabetic nephropathy near the beginning at microalbuminuria stage with angiotensin-II-AT1 receptor blockers (ARBs) improves blood pressure control and halts disease progression of diabetic nephropathy. In fact, ARBs exert renoprotective effects independently of their blood pressure lowering effect, as they have direct defensive action on the diabetic kidney. Indubitably, it would be better if an ARB has both glucose-lowering and blood pressure controlling potentials efficiently. Intriguingly, telmisartan has such possessions considering its dual role of AT1 receptor blocking action and peroxisome proliferator-activated receptor gamma (PPARγ) partial agonistic property. The additional PPARγ agonistic potential of telmisartan could make it a distinctive intervention in the ARB class to prevent the progression of diabetic nephropathy through activation of PPARγ-mediated insulin sensitization, and renal anti-inflammatory and anti-oxidant actions. Indeed, telmisartan reduced insulin resistance and glucose intolerance, and halted the progressive renal dysfunction associated with diabetic nephropathy by inhibiting the incidence of albuminuria, and preventing the progression of glomerulosclerosis, renal interstitial inflammation and fibrosis. This review will discuss the current status of therapeutic potentials of telmisartan in treating diabetic nephropathy.

  12. Nutritional Intervention for a Patient with Diabetic Nephropathy

    OpenAIRE

    Kim, Hee Young

    2014-01-01

    In recent years, several studies have reported that the prevalence of diabetes mellitus is increasing every year, and also the acute and chronic complications accompanying this disease are increasing. Diabetic nephropathy is one of chronic complications of diabetes mellitus, and food intake which is burden to kidney function should be limited. At the same time, diet restriction could deteriorate quality of life of patient with diabetic nephropathy. According to the results of previous studies...

  13. Rodent models of diabetic nephropathy: their utility and limitations

    OpenAIRE

    Kitada M; Ogura Y; Koya D

    2016-01-01

    Munehiro Kitada,1,2 Yoshio Ogura,2 Daisuke Koya1,2 1Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, 2Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan Abstract: Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore, novel therapies for the suppression of diabetic nephropathy must be developed. Rodent models are useful for elucidating the pathogenesis of diseases and test...

  14. Role of Toll-like receptors in diabetic nephropathy.

    Science.gov (United States)

    Mudaliar, Harshini; Pollock, Carol; Panchapakesan, Usha

    2014-05-01

    Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent studies have established that inflammatory responses are central to the pathogenesis of diabetic nephropathy. TLRs (Toll-like receptors) are a family of pattern recognition receptors responsible for the initiation of inflammatory and immune responses. The regulation of TLR2 and TLR4 have been implicated in the pathogenesis of various kidney diseases, and emerging evidence shows their involvement in the perpetuation of inflammation in the diabetic kidney. The present review focuses on the relative contributions of TLR2 and TLR4 in recognizing endogenous ligands relevant to diabetic nephropathy and their subsequent activation of NF-κB (nuclear factor κB), which results in the synthesis and secretion of pro-inflammatory cytokines and chemokines. Moreover, we discuss the pro-inflammatory signalling pathways of TLR2 and TLR4, in which their interruption or blockade may prove to be important therapeutic targets, potentially translated into clinical treatments for diabetic nephropathy. Currently, inhibitors to TLR2 and TLR4 are undergoing clinical trials in various inflammatory models of disease, but none in patients with diabetic nephropathy. Given the existing literature, there is a fundamental necessity to undertake trials in patients with diabetic nephropathy with a focus on renal end points.

  15. [Diagnosis and management of diabetic nephropathy].

    Science.gov (United States)

    Kitada, Munehiro; Koya, Daisuke

    2015-12-01

    Diabetic nephropathy(DN) is the most common cause of chronic kidney disease, leading to end-stage renal disease (ESRD) and cardiovascular disease (CVD). The overall number of patients with DN will continue to increase in parallel with the increasing global pandemic of type 2 diabetes. The detection of albuminuria is most important for diagnosis of early stage of DN, and also estimated glomerular filtration rate (eGFR) should be assessed, because both albuminuria and reduction of GFR are recognized as the independent risk factor for progression of ESRD and initiation of CVD, respectively. Based on landmark clinical trials, both DN and CVD have become preventable by controlling conventional factors, including hyperglycemia targeting HbA1c<7.0%, hypertenstion using renin angiotensin system inhibitors, dyslipidemia using statins or fibrates, and multifactorial treatment.

  16. Computed tomographical evaluation of diabetic nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Ubara, Yoshifumi; Hara, Shigeko; Arizono, Kenji; Katori, Hideyuki; Yamada, Akira; Mimura, Nobuhide [Toranomon Hospital, Tokyo (Japan). Kidney Center; Hagura, Ryoko

    1996-06-01

    Diabetic nephropathy can be regarded mainly as a type of microangiopathy, but is a disease that may also include aspects of macroangiopathy. This is especially true of renal disease in non-insulin dependent diabetes mellitus (NIDDM), which is characterized not only by diabetic glomerulosclerosis, but also by atherosclerosis. We performed morphological studies on the kidney, using computed tomography (CT), focusing on such points as: abdominal aortic calcifications at the level of kidney, calcifications in the renal artery, and wedge-shaped defects on the renal surface. We noted that these findings became more prominent in NIDDM patients during end-stage renal failure than during normal renal function, and were significantly more common in those two NIDDM groups than in age-matched nondiabetic patients without hypertension, hyperlipidemia or gout. NIDDM patients exhibited these features more frequently than IDDM patients. (author)

  17. Treatment of membranous nephropathy in children.

    Science.gov (United States)

    Makker, Sudesh P

    2003-07-01

    Membranous nephropathy (MN) is not a common pediatric glomerular disease and not a common cause of idiopathic nephrotic syndrome (NS) in children. Because of the rarity of the disease, there is only a limited amount of uncontrolled data and no controlled data available in children regarding the treatment of MN. Older uncontrolled data indicate that nearly a quarter of children with NS, whether untreated or treated with various immunosuppressive agents, develop chronic renal failure. Current recommendations for treatment both for children presenting with or without NS therefore are based on controlled data obtained in adults with MN. All children should receive angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs). Children with NS may be treated initially with corticosteroids. If a satisfactory response is not obtained with corticosteroids, then treatment with cyclosporine or chlorambucil can be tried. The protocols of treatment with these drugs are described in this article.

  18. BK Virus Nephropathy in Heart Transplant Recipients.

    Science.gov (United States)

    Joseph, Alin; Pilichowska, Monika; Boucher, Helen; Kiernan, Michael; DeNofrio, David; Inker, Lesley A

    2015-06-01

    Polyomavirus-associated nephropathy (PVAN) has become an important cause of kidney failure in kidney transplant recipients. PVAN is reported to affect 1% to 7% of kidney transplant recipients, leading to premature transplant loss in approximately 30% to 50% of diagnosed cases. PVAN occurring in the native kidneys of solid-organ transplant recipients other than kidney only recently has been noted. We report 2 cases of PVAN in heart transplant recipients, which brings the total of reported cases to 7. We briefly review the literature on the hypothesized causes of PVAN in kidney transplant recipients and comment on whether these same mechanisms also may cause PVAN in other solid-organ transplant recipients. PVAN should be considered in the differential diagnosis when evaluating worsening kidney function. BK viremia surveillance studies of nonkidney solid-organ recipients should be conducted to provide data to assist the transplantation community in deciding whether regular monitoring of nonkidney transplant recipients for BK viremia is indicated.

  19. Diabetic Nephropathy in Women With Preexisting Diabetes

    DEFF Research Database (Denmark)

    Ringholm, Lene; Damm, Julie Agner; Vestgaard, Marianne

    2016-01-01

    In women with preexisting diabetes and nephropathy or microalbuminuria, it is important to deliver careful preconception counselling to assess the risk for the mother and the foetus, for optimizing glycaemic status and to adjust medical treatment. If serum creatinine is normal in early pregnancy......, kidney function is often preserved during pregnancy, but complications such as severe preeclampsia and preterm delivery are still common. Perinatal mortality is now comparable with that in women with diabetes and normal kidney function. Besides strict glycaemic control before and during pregnancy, early...... and intensive antihypertensive treatment is important to optimize pregnancy outcomes. Methyldopa, labetalol, nifedipine and diltiazem are considered safe, whereas angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers should be stopped before or at confirmation of pregnancy...

  20. Complex networks analysis of obstructive nephropathy data

    Science.gov (United States)

    Zanin, M.; Boccaletti, S.

    2011-09-01

    Congenital obstructive nephropathy (ON) is one of the most frequent and complex diseases affecting children, characterized by an abnormal flux of the urine, due to a partial or complete obstruction of the urinary tract; as a consequence, urine may accumulate in the kidney and disturb the normal operation of the organ. Despite important advances, pathological mechanisms are not yet fully understood. In this contribution, the topology of complex networks, based on vectors of features of control and ON subjects, is related with the severity of the pathology. Nodes in these networks represent genetic and metabolic profiles, while connections between them indicate an abnormal relation between their expressions. Resulting topologies allow discriminating ON subjects and detecting which genetic or metabolic elements are responsible for the malfunction.

  1. Advances in Murine Models of Diabetic Nephropathy

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    Li-li Kong

    2013-01-01

    Full Text Available Diabetic nephropathy (DN is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients. However, the pathogenesis of DN is still unclear. Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies. Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans. Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.

  2. Mouse Models for Studying Diabetic Nephropathy.

    Science.gov (United States)

    Chow, Bryna S M; Allen, Terri J

    2015-06-01

    Diabetic nephropathy (DN) is a term used to describe kidney damage cause by diabetes. With DN as one of the leading causes of end-stage renal disease worldwide, there is a strong need for appropriate animal models to study DN pathogenesis and develop therapeutic strategies. To date, most experiments are carried out in mouse models as opposed to other species for several reasons including lower cost, ease of handling, and easy manipulation of the mouse genome to generate transgenic and knockout animals. This unit provides detailed insights and technical knowledge in setting up one of the most widely used models of DN, the streptozotocin (STZ)-induced model. This model has been extensively exploited to study the mechanism of diabetic renal injury. The advantages and limitations of the STZ model and the availability of other genetic models of DN are also discussed.

  3. Association of Diabetic Nephropathy and Liver Disorders

    Science.gov (United States)

    Malawadi, BN

    2016-01-01

    Introduction Liver disorder is known to be a risk factor for Diabetes Mellitus (DM) and diabetic patients are at risk of developing liver disorders. Association of liver and renal disease is less explored in the field of research; hence, we conducted a retrospective study on this. Aim To compare the renal and liver profiles of type II DM patients compared to healthy controls and find the association between the two profiles in diabetics. Materials and Methods The renal and liver profiles of 68 type II DM patients and 58 controls were compared. Estimated Glomerular Filtration Rate (GFR) (eGFR) was calculated using Modification of Diet in Renal Disease (MDRD) formula and was taken as a tool to grade different stages of diabetic nephropathy. Comparison of liver profiles between different stages of diabetic nephropathy was done. Correlations and associations were studied between eGFR and liver enzymes and Bilirubin. Results A significant elevation in Total Bilirubin (TB) (p< 0.15), Direct Bilirubin (DB) (p< 0.0035), Aspartate Amino Transferase (AST) and Alanine Amino Transferase (ALT) (p<0.0001) levels in diabetics was noted. An elevated eGFR and a significant correlation between eGFR and liver enzymes were observed. A significant association between liver and renal disease has been obtained in diabetics (p=0.0136). Conclusion Significantly, high liver function tests and low eGFR were observed in type II diabetics. A significant positive correlation between liver enzymes (AST and ALT) and eGFR suggest a possible association between liver and kidney functions in DM. PMID:27891331

  4. Exogenous kallikrein protects against diabetic nephropathy.

    Science.gov (United States)

    Liu, Wenjuan; Yang, Yeping; Liu, Yemei; Lu, Xiaolan; Guo, Shizhe; Wu, Meng; Wang, Meng; Yan, Linling; Wang, Qinghua; Zhao, Xiaolong; Tong, Xian; Hu, Ji; Li, Yiming; Hu, Renming; Stanton, Robert C; Zhang, Zhaoyun

    2016-11-01

    The kallikrein-kinin system has been shown to be involved in the development of diabetic nephropathy, but specific mechanisms are not fully understood. Here, we determined the renal-protective role of exogenous pancreatic kallikrein in diabetic mice and studied potential mechanisms in db/db type 2 diabetic and streptozotocin-induced type 1 diabetic mice. After the onset of diabetes, mice were treated with either pancreatic kallikrein (db/db+kallikrein, streptozotocin+kallikrein) or saline (db/db+saline, streptozotocin+saline) for 16 weeks, while another group of streptozotocin-induced diabetic mice received the same treatment after onset of albuminuria (streptozotocin'+kallikrein, streptozotocin'+saline). Db/m littermates or wild type mice were used as non-diabetic controls. Pancreatic kallikrein had no effects on body weight, blood glucose and blood pressure, but significantly reduced albuminuria among all three groups. Pathological analysis showed that exogenous kallikrein decreased the thickness of the glomerular basement membrane, protected against the effacement of foot process, the loss of endothelial fenestrae, and prevented the loss of podocytes in diabetic mice. Renal fibrosis, inflammation and oxidative stress were reduced in kallikrein-treated mice compared to diabetic controls. The expression of kininogen1, tissue kallikrein, kinin B1 and B2 receptors were all increased in the kallikrein-treated compared to saline-treated mice. Thus, exogenous pancreatic kallikrein both prevented and ameliorated diabetic nephropathy, which may be mediated by activating the kallikrein-kinin system.

  5. Diabetic nephropathy in Africa: A systematic review

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    AIM To determine the prevalence and incidence ofdiabetic nephropathy in Africa.METHODS: We performed a systematic narrativereview of published literature following the MOOSEGuidelines for Meta-Analysis and Systematic Reviewsof Observational Studies. We searched PubMed-MEDLINE for all articles published in English and Frenchlanguages between January 1994 and July 2014 usinga predefined strategy based on the combination ofrelevant terms and the names of each of the 54 Africancountries and African sub-regions to capture the largestnumber of studies, and hand-searched the referencelists of retrieved articles. Included studies reported onthe prevalence, incidence or determinants of chronickidney disease (CKD) in people with diabetes withinAfrican countries.RESULTS: Overall, we included 32 studies from 16countries; two being population-based studies andthe remaining being clinic-based surveys. Most of thestudies (90.6%) were conducted in urban settings.Methods for assessing and classifying CKD variedwidely. Measurement of urine protein was the mostcommon method of assessing kidney damage (62.5%of studies). The overall prevalence of CKD varied from11% to 83.7%. Incident event rates were 94.9% forproteinuria at 10 years of follow-up, 34.7% for endstagerenal disease at 5 years of follow-up and 18.4%for mortality from nephropathy at 20 years of followup.Duration of diabetes, blood pressure, advancingage, obesity and glucose control were the commondeterminants of kidney disease.CONCLUSION: The burden of CKD is importantamong people with diabetes in Africa. High quality datafrom large population-based studies with validatedmeasures of kidney function are still needed to bettercapture the magnitude and characteristics of diabeticnephropathy in Africa.

  6. Role of metabolic control on diabetic nephropathy

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    Macedo Célia Sperandéo

    2002-01-01

    Full Text Available OBJECTIVE: The aim of this investigation was studying the influence of glucose metabolic control on diabetic nephropathy. The authors observed the effect of acarbose, insulin, and both drugs on the metabolic control and development of mesangial enlargement of kidney glomeruli in alloxan-diabetic rats. METHODS: Five groups of Wistar rats were used: normal rats (N, non-treated alloxan-diabetic rats (D, alloxan-diabetic rats treated with acarbose (AD, alloxan-diabetic rats treated with insulin (ID, and alloxan-diabetic rats treated with insulin plus acarbose (IAD. The following parameters were evaluated: body weight; water and food intake; diuresis; blood and urine glucose levels; and the kidney lesions: mesangial enlargement and tubule cell vacuolization. Renal lesions were analysed using a semi-quantitative score 1, 3, 6, 9, and 12 months after diabetes induction. RESULTS: Diabetic rats showed a marked increase of glycemia, urinary glucose levels, diuresis, water and food intake, and weight loss, while the treated diabetic rats showed significant decreased levels of these parameters. The most satisfactory metabolic control was that of diabetic rats treated with acarbose + insulin. There was a significant mesangial enlargement in diabetic rats compared to normal rats from the third up to the 12th month after diabetes induction, with a significant difference between the animals treated with acarbose + insulin and non-treated diabetic rats. A difference between the animals treated with acarbose or insulin alone and non-treated diabetics rats was not seen. CONCLUSIONS: The authors discuss the results stressing the role of diabetic metabolic control in the prevention of diabetic nephropathy.

  7. Contrast-induced nephropathy in interventional cardiology

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    Sudarsky D

    2011-07-01

    Full Text Available Doron Sudarsky, Eugenia NikolskyCardiology Department, Rambam Health Care Campus and Technion-Israel Institute of Technology, Haifa, IsraelAbstract: Development of contrast-induced nephropathy (CIN, ie, a rise in serum creatinine by either ≥0.5 mg/dL or by ≥25% from baseline within the first 2–3 days after contrast administration, is strongly associated with both increased inhospital and late morbidity and mortality after invasive cardiac procedures. The prevention of CIN is critical if long-term outcomes are to be optimized after percutaneous coronary intervention. The prevalence of CIN in patients receiving contrast varies markedly (from <1% to 50%, depending on the presence of well characterized risk factors, the most important of which are baseline chronic renal insufficiency and diabetes mellitus. Other risk factors include advanced age, anemia, left ventricular dysfunction, dehydration, hypotension, renal transplant, low serum albumin, concomitant use of nephrotoxins, and the volume of contrast agent. The pathophysiology of CIN is likely to be multifactorial, including direct cytotoxicity, apoptosis, disturbances in intrarenal hemodynamics, and immune mechanisms. Few strategies have been shown to be effective to prevent CIN beyond hydration, the goal of which is to establish brisk diuresis prior to contrast administration, and to avoid hypotension. New strategies of controlled hydration and diuresis are promising. Studies are mixed on whether prophylactic oral N-acetylcysteine reduces the incidence of CIN, although its use is generally recommended, given its low cost and favorable side effect profile. Agents which have been shown to be ineffective or harmful, or for which data supporting routine use do not exist, include fenoldopam, theophylline, dopamine, calcium channel blockers, prostaglandin E1, atrial natriuretic peptide, statins, and angiotensin-converting enzyme inhibitors.Keywords: contrast-induced nephropathy, contrast media

  8. Differential effects of low-dose fenofibrate treatment in diabetic rats with early onset nephropathy and established nephropathy.

    Science.gov (United States)

    Kadian, Supriya; Mahadevan, Nanjaian; Balakumar, Pitchai

    2013-01-05

    We have previously shown that low-dose fenofibrate treatment has an ability to prevent diabetes-induced nephropathy in rats. We investigated here the comparative pre- and post-treatment effects of low-dose fenofibrate (30 mg/kg/day p.o.) in diabetes-induced onset of nephropathy. Rats were made diabetics by single administration of streptozotocin (STZ, 55 mg/kg i.p.). The development of diabetic nephropathy was assessed biochemically and histologically. Moreover, lipid profile and renal oxidative stress were assessed. Diabetic rats after 8 weeks of STZ-administration developed apparent nephropathy by elevating serum creatinine, blood urea nitrogen and microproteinuria, and inducing glomerular-capsular wall distortion, mesangial expansion and tubular damage and renal oxidative stress. Fenofibrate (30 mg/kg/day p.o., 4 weeks) pretreatment (4 weeks after STZ-administration) markedly prevented diabetes-induced onset of diabetic nephropathy, while the fenofibrate (30 mg/kg/day p.o., 4 weeks) post-treatment (8 weeks after STZ-administration) was less-effective. However, both pre-and post fenofibrate treatments were effective in preventing diabetes-induced renal oxidative stress and lipid alteration in diabetic rats though the pretreatment was slightly more effective. Conversely, both pre-and post fenofibrate treatments did not alter elevated glucose levels in diabetic rats. It may be concluded that diabetes-induced oxidative stress and lipid alteration, in addition to a marked glucose elevation, play a detrimental role in the onset of nephropathy in diabetic rats. The pretreatment with low-dose fenofibrate might be a potential therapeutic approach in preventing the onset of nephropathy in diabetic subjects under the risk of renal disease induction. However, low-dose fenofibrate treatment might not be effective in treating the established nephropathy in diabetic subjects.

  9. Morphological variation of the Common Lizard (Zootoca vivipara Jacquin, 1787 in the Central Balkans

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    Ljubisavljević Katarina

    2010-01-01

    Full Text Available The variation in some of the morphometric, meristic and qualitative characters of the Common Lizard (Zootoca vivipara in five population samples from mountains of the Central Balkans was analyzed using univariate and multivariate statistics. The morphological differentiation was greater in males than in females and is more expressed in the morphometric than in the pholidosis and qualitative characters. The largest differences in morphometric traits appeared between the populations from the Šara and Stara Planina mountains. The 'median' pileus pattern generally prevailed, with the appearance of other states in a certain proportion in some of the populations. Further analyses of the possible morphological and ecological distinctions of the population from Mt Tara are proposed. .

  10. Improvement in kidney transplantation in the Balkans after the Istanbul Declaration: where do we stand today?

    Science.gov (United States)

    Spasovski, Goce; Busic, Mirela; Delmonico, Francis

    2016-02-01

    Due to the limited access to kidney transplantation (KTx) in developing countries, desperate patients have engaged in the purchase and sale of kidneys. In 2004, the World Health Assembly urged member states to protect the poor and vulnerable from being exploited through practices of illegal organ trafficking that had become widespread throughout the world. In 2008, the international transplant community convened a summit of transplant professionals, legal experts and ethicists to combat organ trafficking, transplant tourism and transplant commercialism that resulted in the Declaration of Istanbul (DOI). The South-Eastern Europe Health Network (SEEHN) represents a nine country multigovernmental collaboration on health systems. The Regional Health Development Centre on Organ Donation and Transplant Medicine (RHDC) was established in 2011 in Croatia to facilitate cooperation among south-eastern European countries to improve organ transplantation within the Balkan region. Since 2011, a collaboration between the RHDC, the Custodian Group of the DOI (DICG) and SEEHN professionals has enhanced strategic planning and definition of country-specific action plan priorities on organ donation and transplantation. Data of kidney transplantation provided in this report show a significant increase in transplantation activities in a 4-year period in Macedonia, Moldova, Bosnia and Hercegovina, Romania and Montenegro. The success of the donation and transplantation programmes was influenced by the engagement of key professionals and the establishment of organizational infrastructure with the implementation of an appropriate funding model. In conclusion, the DOI has provided an ethical framework for engagement of health professionals from south-eastern European countries. The newly established SEEHN RHDC as a technical coordinating body greatly contributed in building institutional capacity and strengthening regional collaboration between health authorities and professionals within

  11. The Little Ice Age and its Spatial Variability across the Balkans

    Science.gov (United States)

    Kulkarni, C.; Peteet, D. M.; Boger, R. A.

    2015-12-01

    Using biological proxies (pollen, spores, and charcoal), geochemical signals through X-ray fluorescence, and AMS 14C based chronology, we present a correlation between two new high resolution Little Ice Age (LIA) records from the Central Balkans that are part of one of the least studied regions of Europe. The sediments extracted from a western sinkhole and central Serbian oxbow lake are analyzed at 8-10-cm intervals to capture the nature and magnitude of the LIA at a resolution of 20 years. During the 15th-19th CE, indigenous tree (e.g. Quercus, Acer, Pinus) and herbaceous (e.g. Poaceae, Chenopodiaceae, Artemisia) pollen from these records demonstrate fluctuations in woodland-grassland dynamics. While tree populations from Central Serbia remain comparatively stable (40-60%), the trees of western Serbia vacillate drastically between 15% and 50%. Similarly, central Serbian grasses show variations of ~18-36% whereas the western Serbian grass populations exhibit abrupt oscillations between high (55%) and low (19%) percentages. As a proxy for surface erosion and clastic input into the lakes, the 1-cm resolution potassium and titanium counts are in strong agreement with varying herbaceous taxa. These variations in ecological signals across the cores can account for local factors including altitude, terrain exposure, soils etc., however, the dynamic human component of the landscape is evident through crop pollen (e.g. Cerealia, Juglans) and microscopic charcoal highlighting the dominant role of people in ecological changes. Although the two sites show certain differences in charcoal concentration, extremely high charcoal indicates accelerated land clearance between the 15th and 17th CE. Until the beginning of 18th CE, the cultivars (e.g. Secale, Triticum) occur with very low percentages and then peak to suggest improved agriculture in the region. In the post-LIA era, the 20th CE exhibits increased arboreal percentages and declining grasslands in both the two Central

  12. Tracing lexical borrowings in the Balkans Albanian loan-words in the Serbian speech of Prizren

    Directory of Open Access Journals (Sweden)

    Petrović Snežana

    2003-01-01

    Full Text Available During the past centuries the city of Prizren has persisted as a unique multiethnic and multicultural environment atypical even for the Balkans, well-known for its ethnic, linguistic, cultural and religious diversity. Various nations used to live and pass through Prizren in the course of more than six centuries – the Serbs Turks, Albanians, Aromanians, Greeks and others – leaving their specific marks, visible on the city itself as well as the life and the mentality of its inhabitants. One of the most vivid testimonies to this long-term coexistence can be seen in vernaculars of the local population. This paper presents some Albanian loan-words from the Serbian speech of Prizren hitherto not registered (or not recognised as such in the respective etymological dictionaries and linguistic studies. The aim of this work is to offer their etymological analysis, through an investigation of the ways and mechanisms of lexical borrowing in the limited area of this town and to observe this phenomenon in a broader Balkan perspective. Analyzed are the following words: bajmak m., adj. indecl. "with bow legs (of man or horse", cub adj. indecl. "short; short-tailed", cub m., adj. indecl. "robber, outlaw", ćul adj. indecl. "soaking wet", điza f. "kind of crumbly cheese", glistra f. "worm", korse, korsem, krsem adv. "perhaps, as if", kulme n., kuljma f. "top of the roof", ljajka f. "lie", ljaper m. "idler", ljočka f. "darling, sweetheart", ljum adj. indecl. "dear", ljunga f. "boil; swelling", putarka f. "salted and dried caviar", ravš adv. "flat", roktar m. "servant, attendant", škret adj. "lonely, deserted, empty", škrum adj. indecl. "dry as ashes".

  13. Dynamics of the Balkans deformation : regional impact of the Western Hellenic subduction-collision transition

    Science.gov (United States)

    Métois, Marianne; D'Agostino, Nicola; Copley, Alex

    2016-04-01

    The increasing number of GPS measurements in the Balkan Peninsula over the last decades has brought new insights on the kinematic of the Eurasian plate there, revealing a significant ( 5 mm/yr) clockwise rotation motion of the entire region around the Scutari-Pec line in North Albania [Métois et al. 2015]. The focal mechanisms of recent earthquakes in this seismically active area are consistent with this deformation pattern. In this study, we use simple dynamic models based on the thin viscous sheet approximation to test the influence of realistic kinematic boundary conditions and gradients of gravitational potential energy on the predicted surface deformation in the region. In addition, we compare the surface velocity field with maps of azimuthal anisotropy at depth to assess whether mantle motions may drive part of the observed lithosphere deformation. We show that the observed shearing and rotation around Albania can be explained at the first order by kinematic boundary conditions applied on a viscous lithosphere (η ˜ 2.1021Pa.s), while GPE gradients may control the smaller-scale patterns of deformation. Our models appear to be very sensitive to the abrupt velocity-change imposed across the Kefalonia fault in northern Greece where the subduction to collision transition takes place. We propose that the large-scale shearing of the region observed in the GPS data results mainly from this lithospheric tearing, that is one of the most active structure in the area. This hypothesis implies that the slab tearing initiation would have been an important controlling factor on the tectonic history of the Balkans and that the current velocity gradient across the Kefalonia fault is probably sufficient to trigger a large scale shearing propagating up to central Serbia.

  14. Mechanisms of diabetic nephropathy--old buddies and newcomers part 1.

    Science.gov (United States)

    Nawroth, P P; Isermann, B

    2010-10-01

    Diabetic nephropathy is the most frequent cause of terminal kidney failure in industrialized countries. In addition, the manifestation of diabetic nephropathy is associated with a poor prognosis for affected patients. Current therapies are based on established pathophysiological models. However, despite reflecting significant progress in our understanding of diabetic nephropathy, the translational efforts fell short their expectations. The current review summarizes recent studies which provided new insights into established mechanisms (part 1) and studies identifying new candidate mechanisms (part 2) underlying diabetic nephropathy.

  15. Angiotensin converting enzyme gene polymorphism in type II diabetics with nephropathy

    OpenAIRE

    Naresh, V. V. S.; Reddy, A. L. K.; Sivaramakrishna, G.; Sharma, P. V. G. K.; Vardhan, R. V.; Kumar, V. Siva

    2009-01-01

    Nephropathy is an important and a frequent complication of long-term type II diabetic nephropathy. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. Recent studies have implicated association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and nephropathy. The deletion gene polymorphism of ACE gene has been shown to be associated with increased activity of this enzyme. This study examines th...

  16. Endothelial nitric oxide synthase gene haplotypes and diabetic nephropathy among Asian Indians

    DEFF Research Database (Denmark)

    Ahluwalia, Tarun Veer Singh; Ahuja, Monica; Rai, Taranjit Singh

    2008-01-01

    .23-16.31). Haplotype with all the wild alleles (T-b-G) was found to be associated with a decreased risk of nephropathy (OR: 0.68, P = 0.005) and haplotype with all mutant alleles (C-a-T) was associated with higher risk of diabetic nephropathy as compared to diabetes without nephropathy group (OR: 2.6, P = 0...

  17. Natural radioactivity level in materials used for medieval vaulting in the territory of the central Balkan region

    Directory of Open Access Journals (Sweden)

    Bjelić Igor S.

    2016-01-01

    Full Text Available This work presents the results of an investigation undertaken to determine the level of natural radioactivity in the traditional building materials used for medieval indoor vaulted constructions in the territory of the central Balkan region. Indoor radiation exposure varies appreciably if it comes from the earth building materials, hence the presence of natural radioisotopes of 226Ra, 232Th, and 40K in masonry vaulted constructions was analyzed using gamma ray spectrometry. In addition, the internal health hazard index, the absorbed dose rates and the effective annual doses were calculated. The results were then compared both with the reported data from the previous studies concerning the territory of the Balkan Peninsula, as well as with the worldwide values for the materials of historic buildings. The results obtained from the materials examined in this paper all showed the radioactivity levels below the maximum permitted values. [Projekat Ministarstva nauke Republike Srbije, br. 171007 i br. 43009

  18. Notes on autumn-winter stomach contents of the Stone Marten (Martes foina in the Balkan Mountains, Central Bulgaria

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    Masumi Hisano

    2014-05-01

    Full Text Available We studied autumn-winter food (November-February, 1997-2003 of the Stone Marten in the Balkan Mountains, Central Bulgaria. A total of 26 stomachs (18 of males and eight of females were examined, of which contents was expressed as the number of occurrence and relative frequency of occurrence. The result clearly showed that rodents are primary prey for the Stone Marten. Birds and insects were the following categories consumed. The edible dormouse was detected as a prey for the first time in Bulgaria. Besides, wild ungulates and domestic animals were occasionally scavenged, while neither fruits nor artificial materials were detected in the marten stomachs. Thus, our study showed that the Stone Marten in the Balkan Mountains tended to be more carnivorous in winter.

  19. The Importance of the geographical position of Kosovo in increasing the Trade, Transit and International Transport in the Balkans

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    Ramadan Mazrekaj

    2015-07-01

    Full Text Available This paper analyzes the effect of the main highways in Kosovo (Roads 6 and 7 in the development of trade and transport of goods. In this sense, another objective of this paper is the effect of the Kosovo highways (Kosovo Roads 6 and 7 in developing the Albanian Sea Ports (Port of Durres, Vlora and Shengjin. Many Balkan countries are working in the improvement of roads and rail capacity in order to develop multimodal transport, aiming always at strengthening a dominant position in the Balkans, to serve as a connection bridge for the transportation of goods between Asia and Europe. Parts of this paper are also the movement of goods, trade exchange between Kosovo and other European countries, and a short analysis of the Trans CAD software program consisting of calculations of the quantity of goods that can be traded in Kosovo or through its territory (transit.

  20. THE IMPACT OF EU CONDITIONALITY IN THE WESTERN BALKANS. A COMPARATIVE APPROACH: BOSNIA AND HERZEGOVINA – BULGARIA

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    Octavia MOISE

    2015-12-01

    Full Text Available The purpose of this article is to analyse the security environment at the beginning of the XXIst century and to assess the impact of EU conditionality in the Western Balkans. The paper will analyse the redistribution of power and the new challenges that send the European Union at a crossroad. To explain such complex phenomena, we will use a comprehensive framework based on realism, liberal institutionalism, and constructivism. The central part of the paper will analyse EU conditionality in the Western Balkans – along with its characteristics, particularities, difficulties – and the impact of the degree of sovereignty. The case-study will provide a comparative analysis between EU conditionality in Bosnia and Herzegovina and Bulgaria proving that sovereignty matters for the conditionality-compliance relationship.

  1. Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy.

    Science.gov (United States)

    Kume, Shinji; Koya, Daisuke

    2015-12-01

    Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is increasing worldwide. The most effective treatment strategy for the condition is intensive treatment to strictly control glycemia and blood pressure using renin-angiotensin system inhibitors. However, a fraction of patients still go on to reach end stage renal disease even under such intensive care. New therapeutic targets for diabetic nephropathy are, therefore, urgently needed. Autophagy is a major catabolic pathway by which mammalian cells degrade macromolecules and organelles to maintain intracellular homeostasis. The accumulation of damaged proteins and organelles is associated with the pathogenesis of diabetic nephropathy. Autophagy in the kidney is activated under some stress conditions, such as oxidative stress and hypoxia in proximal tubular cells, and occurs even under normal conditions in podocytes. These and other accumulating findings have led to a hypothesis that autophagy is involved in the pathogenesis of diabetic nephropathy. Here, we review recent findings underpinning this hypothesis and discuss the advantages of targeting autophagy for the treatment of diabetic nephropathy.

  2. Paracetamol and analgesic nephropathy: Are you kidneying me?

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    Waddington F

    2014-12-01

    Full Text Available Freya Waddington, Mark Naunton, Jackson Thomas Faculty of Health, University of Canberra, Canberra, ACT, Australia Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of analgesics. Phenacetin was subsequently exclusively blamed for this disease. However, the role of a single analgesic as a sole cause of analgesic nephropathy was challenged, and a number of researchers have since attempted to determine the extent of involvement of other analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs, aspirin, and paracetamol. Case presentation: We present the case of an 83-year-old woman with a history of NSAID-induced nephropathy with poor pain control and reluctance to use paracetamol. We attempt to briefly review the evidence of paracetamol being implicated in the development of analgesic-induced nephropathy. Conclusion: There is a lack of concrete data regarding causative analgesics, including paracetamol. Patients should therefore not be withheld paracetamol, an effective and commonly recommended agent, for fear of worsening renal function. Keywords: kidney, paracetamol, nephropathy, phenacetin

  3. Vitamin D receptor and its protective role in diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    Guan Xiaoling; Yang Huajie; Zhang Wei; Wang Huanjun; Liao Lin

    2014-01-01

    Objective To review the advances of studies on vitamin D receptor and its role in the pathogenesis of diabetic nephropathy.Data sources A comprehensive search of the PubMed literatures without restriction on the publication date was carried out using keywords such as vitamin D receptor and diabetic nephropathy.Study selection Articles related to vitamin D receptor and diabetic nephropathy were selected and carefully analyzed.Results The ligands as well as construction and tissue distribution of vitamin D receptor were summarized.Pathogenesis of diabetic nephropathy was analyzed.The mechanisms underlying the renoprotective role of vitamin D receptor including inhibition of renin-angiotensin system,anti-inflammation,anti-fibrosis and the reduction of proteinuria were reviewed.Mounting evidences from animal and clinical studies have suggested that vitamin D therapy has beneficial effects on the renal systems and the underlying renoprotective mechanisms of the vitamin D receptor-mediated signaling pathways is a hot research topic.Conclusion Our study suggests that vitamin D receptor has a great potential for preventing the progression of diabetic nephropathy via multiple mechanisms.

  4. Vascular endothelial dysfunction: a tug of war in diabetic nephropathy?

    Science.gov (United States)

    Balakumar, Pitchai; Chakkarwar, Vishal Arvind; Krishan, Pawan; Singh, Manjeet

    2009-03-01

    Vascular endothelium regulates vascular tone and maintains free flow of blood in vessels. Vascular endothelial dysfunction (VED) results in reduced activation of endothelial nitric oxide synthase (eNOS), reduced generation and bioavailability of nitric oxide (NO) and increased production of reactive oxygen species (ROS). The eNOS uncoupling in VED leads to eNOS mediated production of ROS that further damage the endothelial cells by upregulating the proinflammatory mediators and adhesion molecules. VED has been associated in the pathogenesis of hypertension, atherosclerosis, coronary artery diseases, diabetes mellitus and nephropathy. Diabetes is a chronic metabolic disorder characterized by hyperglycemia followed by micro and macrovascular complications. A correlation between diabetes and VED has been demonstrated in various studies. The downregulation of eNOS in diabetes has been noted to accelerate diabetic nephropathy. Moreover, various endogenous vasoconstrictors are also upregulated in diabetic nephropathy. VED has been shown to be involved in diabetic nephropathy by inducing nodular glomerulosclerosis followed by glomerular basement membrane thickness and mesangial expansion, which ultimately decline glomerular filtration rate (GFR). Thus it is suggested that diabetes-induced VED could be one of the culprits involved in the pathogenesis of diabetic nephropathy.

  5. Natural radioactivity level in materials used for medieval vaulting in the territory of the central Balkan region

    OpenAIRE

    Bjelić Igor S.; Todorović Dragana J.; Krneta-Nikolić Jelena D.; Lazarević Đorđe R.; Stanković Koviljka Đ.

    2016-01-01

    This work presents the results of an investigation undertaken to determine the level of natural radioactivity in the traditional building materials used for medieval indoor vaulted constructions in the territory of the central Balkan region. Indoor radiation exposure varies appreciably if it comes from the earth building materials, hence the presence of natural radioisotopes of 226Ra, 232Th, and 40K in masonry vaulted constructions was analyzed using gamma ...

  6. Corruption in the Balkans: An Examination of the Ties Between Government and Crime in Several Southeast European Countries

    Science.gov (United States)

    2013-12-01

    is by female bribe payers; Balkan women, who are almost as likely as men to offer a kickback to a public official, “are more likely to pay a bribe in...priorities. 3. Using Social Entrepreneurship to Fight Corruption Would Increase Transparency In his book How to Change the World: Social Entrepreneurs ...and the Power of New Ideas, David Bornstein defines social entrepreneurs as individuals and private citizens who are “advancing systemic solutions to

  7. Effects of different production systems on carcass and meat quality of sheep and lamb from Western Balkan and Norway

    OpenAIRE

    Bjelanovic, Milena; Grabez, Vladana; Vucic, Goran; Martinovic, Aleksandra; Lima, Lene Ruud; Markovic, Bozidarka; Egelandsdal, Bjørg

    2015-01-01

    The identification of meat quality characteristics from selected breeds grazing in specific regions is particularly relevant to achieve a marketing advantage. Longisimus thoracis at lumborum (LTL) from the indigenous Western Balkan (WB) sheep - VlašićkaPramenka (VP) sheep and lambs, and Pivska Pramenka (PP) sheep grazing in Bosnia & Herzegovina (B&H) and Montenegro (MN), respectively, was compared regarding carcass and meat qualities to the crossbred Norweg...

  8. Tendances et différences démographiques dans les Balkans

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    Parant, Alain

    2009-12-01

    Full Text Available The Balkans, which had long been characterized by higher fertility and earlier mortality than the more western and northern parts of the European continent, have become demographically modern. They are not for that reason any less diverse. This is witnessed, for example, by the gap that separates Bulgaria, which has long made the demographic transition, and Albania, the Former Yugoslav Republic of Macedonia, or Kosovo, where the natural population growth exceeds by far the migratory deficit. It is also witnessed by the very large spectrum of degrees of aging. Political and economic changes in the Balkans, the crises that accompanied them, the doubts that they have caused concerning the collective future, have reinforced the general tendencies toward delayed marriage and fertility, as well as toward reduced marriage and fertility rates. This has de facto consolidated the tendency toward demographic aging. Migrations, especially the migrations directly or indirectly related to the conflicts in former Yugoslavia, have also contributed to the modification of the demographic landscape and to the altering of the dynamic of the affected populations. They have also had an effect on the ethnic distribution of these populations. In the Balkans, whose bases have been strongly shaken in the past twenty years, heavy fertility and mortality tendencies limit the spectrum of possible mid-to-long term futures. There are also important consequences on the socioeconomic plan. All this in a political context, internal and external, that is the source of many questions.

    Los Balcanes, que se caracterizaron durante mucho tiempo por una fecundidad más elevada y una mortalidad más precoz que en las partes oeste y norte del continente europeo, están a partir de ahora inscritos en la modernidad demográfica. A pesar de ello son extremadamente diversos. Así lo confirma la distancia que separa, por ejemplo, Bulgaria, tierra de transición demográfica antigua

  9. Secular variation of the Earth's magnetic field in the Balkan region during the last eight millennia based on archaeomagnetic data

    Science.gov (United States)

    Tema, E.; Kondopoulou, D.

    2011-08-01

    The first archaeomagnetic secular variation (SV) curves for the whole Southern Balkan Peninsula are presented. These are based on all data within a 700 km circle centred at Thessaloniki (40.60oN, 23.00oE). This data set consists of 325 directional and 625 intensity data mainly from Greece, Bulgaria, Serbia and southern Hungary. Some data from southern Italy are also included. The sliding moving window technique, was used to calculate a continuous SV curve for intensity while the directional SV curves were calculated using the bivariate extension of the Fisher statistics. These curves are well constrained and clearly show the main features of the geomagnetic field variation in this region during the last eight millennia. Comparisons with the predictions of the SCHA.DIF.3K and SCHA.DIF.8K regional and the CALS7K.2 and ARCH3K.1 global geomagnetic field models show a good agreement for the last 3000 years but differences for older times. The Balkan SV curves identify several rapid changes of the geomagnetic field in eastern Europe and can be used as reference curves for archaeomagnetic dating in the Balkan Peninsula.

  10. Characterization of several milk proteins in Domestic Balkan donkey breed during lactation, using lab-on-a-chip capillary electrophoresis

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    Gubić Jasmina

    2016-01-01

    Full Text Available Domestic Balkan donkey (Equus asinus asinus is a native donkey breed, primarily found in the northern and eastern regions of Serbia. The objective of the study was to analyze proteins of Domestic Balkan donkey milk during the lactation period (from the 45th to the 280th day by applying Lab-on-a-Chip electrophoresis. The chip-based separations were performed on the Agilent 2100 Bioanalyzer in combination with the Protein 80 Plus Lab Chip kit. The protein content of Domestic Balkan donkey milk during the lactation period of 280 days ranged from 1.40 % to 1.92 % and the content of αs1-casein, αs2-casein, b-casein, α-, β- lactoglobulin, lysozyme, lactoferrin and serum albumin was relatively quantified. Lysozyme (1040-2970 mg/L, α-lactalbumin 12 kDa (1990-2730 mg/L and α-lactalbumin 17.7 kDa (2240-3090 mg/L were found to be the proteins with the highest relative concentrations. [Projekat Ministarstva nauke Republike Srbije, br. III46012

  11. The Impact of Ethno Marketing Activities on Consumer Buying Behavior in the Balkans: The Case of Kosovo

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Jusuf Zeqiri

    2016-01-01

    Full Text Available Ethno marketing defines as marketing segmentation approach that groups consumers on the basis of ethnicity. Ethno marketing starts with recognizing the elements of culture as crucial and essential for driving contemporary marketing strategies. Ethno marketing is slowly gaining traction in marketing in multicultural environments, particularly in countries or regions inhabited by consumers from different ethnic backgrounds. This study aims to find whether such marketing activities based on cultural elements practice has any effect on consumers’ buying behavior in the Balkans.  It focuses on consumers in Kosova with the understanding that this is a preliminary exploratory study whose results will form basis for a large study on the Balkan region. The study used a structured questionnaire with the Likert Scale. One hundred, forty-eight responses were received and analyzed using the SPSS statistical software. The results of the analysis show that Albanian consumers in Kosova agree that ethno marketing is important and company marketing activities such as a company’s advertisement and promotion in the language of the ethnic is considered very important during consumers purchase decisions. Furthermore, results reveal that symbols, cultural elements as well as the information dissemination inside the stores and outside seem to be very important for consumers. On the basis of this study, a larger study that covers the different countries in the Balkan region to determine how consumers in the different countries in the region relate to ethno marketing is strongly recommended.

  12. Paternal and maternal lineages in the Balkans show a homogeneous landscape over linguistic barriers, except for the isolated Aromuns.

    Science.gov (United States)

    Bosch, E; Calafell, F; González-Neira, A; Flaiz, C; Mateu, E; Scheil, H-G; Huckenbeck, W; Efremovska, L; Mikerezi, I; Xirotiris, N; Grasa, C; Schmidt, H; Comas, D

    2006-07-01

    The Balkan Peninsula is a complex cultural mosaic comprising populations speaking languages from several branches of the Indo-European family and Altaic, as well as culturally-defined minorities such as the Aromuns who speak a Romance language. The current cultural and linguistic landscape is a palimpsest in which different peoples have contributed their cultures in a historical succession. We have sought to find any evidence of genetic stratification related to those cultural layers by typing both mtDNA and Y chromosomes, in Albanians, Romanians, Macedonians, Greeks, and five Aromun populations. We have paid special attention to the Aromuns, and sought to test genetically various hypotheses on their origins. MtDNA and Y-chromosome haplogroup frequencies in the Balkans were found to be similar to those elsewhere in Europe. MtDNA sequences and Y-chromosome STR haplotypes revealed decreased variation in some Aromun populations. Variation within Aromun populations was the primary source of genetic differentiation. Y-chromosome haplotypes tended to be shared across Aromuns, but not across non-Aromun populations. These results point to a possible common origin of the Aromuns, with drift acting to differentiate the separate Aromun communities. The homogeneity of Balkan populations prevented testing for the origin of the Aromuns, although a significant Roman contribution can be ruled out.

  13. New therapeutic agents in diabetic nephropathy

    Science.gov (United States)

    Kim, Yaeni; Park, Cheol Whee

    2017-01-01

    Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and progression. Currently, there are few therapeutic drugs for DN, which mainly consist of antihypertensive and antiproteinuric measures that arise from strict renin-angiotensin-aldosterone system inactivation. However, these traditional therapies are suboptimal and there is a clear, unmet need for treatments that offer effective schemes beyond glucose control. The complexity and heterogeneity of the DN entity, along with ambiguous renal endpoints that may deter accurate appraisal of new drug potency, contribute to a worsening of the situation. To address these issues, current research into original therapies to treat DN is focusing on the intrinsic renal pathways that intervene with intracellular signaling of anti-inflammatory, antifibrotic, and metabolic pathways. Mounting evidence in support of the favorable metabolic effects of these novel agents with respect to the renal aspects of DN supports the likelihood of systemic beneficial effects as well. Thus, when translated into clinical use, these novel agents would also address the comorbid factors associated with diabetes, such as obesity and risk of cardiovascular disease. This review will provide a discussion of the promising and effective therapeutic agents for the management of DN. PMID:28049280

  14. Histone Lysine Methylation in Diabetic Nephropathy

    Directory of Open Access Journals (Sweden)

    Guang-dong Sun

    2014-01-01

    Full Text Available Diabetic nephropathy (DN belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide. Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called “metabolic memory.” The underlying mechanisms responsible for the development and progression of DN remain poorly understood. Activation of multiple signaling pathways and key transcription factors can lead to aberrant expression of DN-related pathologic genes in target renal cells. Increasing evidence suggests that epigenetic mechanisms in chromatin such as DNA methylation, histone acetylation, and methylation can influence the pathophysiology of DN and metabolic memory. Exciting researches from cell culture and experimental animals have shown that key histone methylation patterns and the related histone methyltransferases and histone demethylases can play important roles in the regulation of inflammatory and profibrotic genes in renal cells under diabetic conditions. Because histone methylation is dynamic and potentially reversible, it can provide a window of opportunity for the development of much-needed novel therapeutic potential for DN in the future. In this minireview, we discuss recent advances in the field of histone methylation and its roles in the pathogenesis and progression of DN.

  15. Effect of loganin on experimental diabetic nephropathy.

    Science.gov (United States)

    Jiang, Wang-Lin; Zhang, Shu-Ping; Hou, Jian; Zhu, Hai-Bo

    2012-02-15

    Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). Loganin, an iridoid glucoside compound was isolated from Cornus officinalis Sieb. et Zucc. This study was conducted to investigate the efficacy of loganin on DN and to elucidate the potential mechanism. High glucose (HG) stimulated cultured human renal proximal tubular epithelial cells (HK-2) analyzed CTGF expression by Western blotting and investigated whether extracellular signal-regulated kinase (ERK) signaling pathway was involved. Streptozotocin (STZ)-induced experimental DN, randomized to receive intragastric (i.g.) of loganin. Renal tissue, blood and urine samples were collected to determine and analyze. In vitro study, loganin reduced CTGF excretion in HG-induced HK-2 cells through the ERK signaling pathway. In vivo study, I.g. of loganin 5 mg/kg or 10 mg/kg significantly ameliorated renal function and increased body weight. Meanwhile, loganin reduced renal CTGF expression by immunohistochemical staining, reduced serum levels of CTGF. Besides, there were no significant differences in blood sugar levels between the loganin groups compared to the STZ-treated group. Furthermore, loganin ameliorated renal pathology. These results suggested that loganin exerts an early renal protective role to DN. Inhibition of CTGF may be a potential target in DN therapy, which highlights the possibility of using loganin to treat DN.

  16. Diabetic nephropathy: changes after diabetes surgery?

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    S. Ros Ruiz

    2013-01-01

    Full Text Available Introduction: Obesity, as a central piece inside metabolic syndrome, is associated with early chronic kidney disease (CKD. In addition, several observational, cross sectional, and longitudinal studies have demonstrated that obesity is as an independent risk factor for the onset, aggravated course, and poor outcomes of CKD including diabetic nephropathy. This implies that when obesity is reversed, many CKD risk factors and CKD itself could be favorably influenced. So all measures aimed at weight loss are recommended to minimize risks from obesity-related conditions and generate improvements in the metabolic profile. Recent evidence shows that bariatric surgery (BS can revert or improve proteinuria and CKD in morbidly obese patients. Objectives and methods: The present review is aimed to provide the evidence regarding the beneficial effects of weight loss after BS in different stages of CKD including kidney transplant recipients, with an special focus on the beneficial effect in reducing or improving proteinuria and renal failure. Furthermore, this updated systematic review of the literature analyzes potential adverse effects that BS could induce not only on renal function but also on morbidity and mortality risk in perioperative and postoperative period. Conclusions: Results from the different case reports, meta analysis as well as systematic review of clinical trials show that obesity treatment by way of lifestyle changes, pharmacotherapies and BS can reduce proteinuria and help to prevent loss of renal function. Also BS may reduce complications, and allow obese patients with end-stage renal disease to undergo kidney transplantation with good results.

  17. Role of Neuropilin-1 in Diabetic Nephropathy

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    Tzvetanka Bondeva

    2015-06-01

    Full Text Available Diabetic nephropathy (DN often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1 is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several domains, thereby allowing the molecule to interact with multiple ligands linking NRP-1 to different pathways through its signaling co-receptors. NRP-1’s role in nervous system development, immunity, and more recently in cancer, has been extensively investigated. Although its relation to regulation of apoptosis and cytoskeleton organization of glomerular vascular endothelial cells was reported, its function in diabetes mellitus and the development of DN is less clear. Several lines of evidence demonstrate a reduced NRP-1 expression in glycated-BSA cultured differentiated podocytes as well as in glomeruli from db/db mice (a model of type 2 Diabetes and in diabetic patients diagnosed with DN. In vitro studies of podocytes implicated NRP-1 in the regulation of podocytes’ adhesion to extracellular matrix proteins, cytoskeleton reorganization, and apoptosis via not completely understood mechanisms. However, the exact role of NRP-1 during the onset of DN is not yet understood. This review intends to shed more light on NRP-1 and to present a link between NRP-1 and its signaling complexes in the development of DN.

  18. [Case of MMF monotherapy for membranous nephropathy].

    Science.gov (United States)

    Kobayashi, Mioko; Kojima, Chiari; Sugiura, Hidekazu; Aoki, Asuka; Itabashi, Mitsuyo; Tsukada, Misao; Takei, Takashi; Uchida, Keiko; Nitta, Kosaku

    2010-01-01

    We report the case of a 58-year-old male patient who visited our hospital for the management of edema and proteinuria. He was diagnosed as having nephrotic syndrome, with serum total protein and albumin levels of 4.6 g/dL and 2.1 g/dL, respectively, and a urinary protein excretion level of 6.0 g/day. A percutaneous renal biopsy showed features of membranous glomerulonephritis, with capillary-wall granular deposits of IgG and C3 on immunofluorescence and subepithelial immune complex deposits on electron microscopy. No other secondary cause of membranous glomerulopathy was found even after extensive investigations. The patient was started on mycophenolate mofetil (MMF) monotherapy (1,500 mg/day), and 18 months after the start of this therapy, the proteinuria decreased to 0.5 g/day, with return to a normal serum albumin level. No digestive symptoms, kidney function worsening or increase in blood pressure were noted during treatment. These findings suggest that MMF monotherapy is effective and safe for the treatment of membranous nephropathy.

  19. Membranous nephropathy: from models to man

    Science.gov (United States)

    Beck, Laurence H.; Salant, David J.

    2014-01-01

    As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause of nephrotic syndrome in adults, were considered idiopathic. We now recognize that MN is an organ-specific autoimmune disease in which circulating autoantibodies bind to an intrinsic antigen on glomerular podocytes and form deposits of immune complexes in situ in the glomerular capillary walls. Here we define the clinical and pathological features of MN and describe the experimental models that enabled the discovery of the major target antigen, the M-type phospholipase A2 receptor 1 (PLA2R). We review the pathophysiology of experimental MN and compare and contrast it with the human disease. We discuss the diagnostic value of serological testing for anti-PLA2R and tissue staining for the redistributed antigen, and their utility for differentiating between primary and secondary MN, and between recurrent MN after kidney transplant and de novo MN. We end with consideration of how knowledge of the antigen might direct future therapeutic strategies. PMID:24892704

  20. Nomenclatural and taxonomic notes on the flora of Serbia and the Balkan Peninsula, I: Caryophyllaceae

    Directory of Open Access Journals (Sweden)

    Niketić M.

    2007-01-01

    Full Text Available The nomenclatural analysis included 12 autochthonous and mostly endemic species from the genera Atocion Adans., Cerastium L., Heliosperma (Rchb. Rchb., and Silene L. (Caryophyllaceae. In conformity with ICBN, 12 new infra­specific taxa are described with locus classicus on the territory of Serbia. Also presented are 24 new nomenclatural combi­nations, including several for endemic taxa not present in Serbia. The nomenclature of certain taxa is supplemented by a short taxonomic-chorological review. Results of these studies will be incorporated in the next volume of "Flora of Serbia".

  1. Diabetic nephropathy and arterial hypertension. The effect of antihypertensive treatment

    DEFF Research Database (Denmark)

    Parving, H H; Andersen, A R; Smidt, U M

    1983-01-01

    in arterial blood pressure to a hypertensive level is an early feature; 43% of the patients had diastolic blood pressure greater than 100 mm Hg. Early and aggressive antihypertensive treatment reduces both albuminuria and the rate of decline in GFR in young patients with diabetic nephropathy.......Our longitudinal study of urinary albumin excretion rate in long-term insulin-dependent diabetics without proteinuria (negative albustix) suggests that early detection of patients at high and low risk of developing persistent proteinuria, i.e., diabetic nephropathy, is possible by using a sensitive...... method for albumin determination. Our prospective studies in young insulin-dependent diabetics with diabetic nephropathy show that the rate of decline in glomerular filtration rate (GFR) varies considerably, with a mean of 0.75 ml/min/mo and a range from 0.1 to 1.50 ml/min/mo, and that an increase...

  2. Treatment and impact of dyslipidemia in diabetic nephropathy.

    Science.gov (United States)

    Toyama, Tadashi; Shimizu, Miho; Furuichi, Kengo; Kaneko, Shuichi; Wada, Takashi

    2014-04-01

    Recent epidemiological research revealed that dyslipidemia is a risk factor for development and progression of diabetic nephropathy. Results from interventional studies revealed the possibility that anti-hyperlipidemic agents have a better effect on diabetic nephropathy through improvement of albuminuria and loss of renal function. In addition, dyslipidemia may be a consequence of albuminuria and renal dysfunction, thereby perpetuating kidney damage. Today, the proportion of diabetic patients receiving statins is increasing due to their beneficial effect on cardiovascular mortality. However, treatment for patients should be determined based on consideration of the risk and benefit of the treatment. More insight into the pathogenesis of diabetic nephropathy and the effects of life-style changes is required.

  3. Adaptive changes in renal mitochondrial redox status in diabetic nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Putt, David A.; Zhong, Qing; Lash, Lawrence H., E-mail: l.h.lash@wayne.edu

    2012-01-15

    Nephropathy is a serious and common complication of diabetes. In the streptozotocin (STZ)-treated rat model of diabetes, nephropathy does not typically develop until 30 to 45 days post-injection, although hyperglycemia occurs within 24 h. We tested the hypothesis that chronic hyperglycemia results in a modest degree of oxidative stress that is accompanied by compensatory changes in certain antioxidants and mitochondrial redox status. We propose that as kidneys progress to a state of diabetic nephropathy, further adaptations occur in mitochondrial redox status. Basic parameters of renal function in vivo and several parameters of mitochondrial function and glutathione (GSH) and redox status in isolated renal cortical mitochondria from STZ-treated and age-matched control rats were examined at 30 days and 90 days post-injection. While there was no effect of diabetes on blood urea nitrogen, measurement of other, more sensitive parameters, such as urinary albumin and protein, and histopathology showed significant and progressive worsening in diabetic rats. Thus, renal function is compromised even prior to the onset of frank nephropathy. Changes in mitochondrial respiration and enzyme activities indicated existence of a hypermetabolic state. Higher mitochondrial GSH content and rates of GSH transport into mitochondria in kidneys from diabetic rats were only partially due to changes in expression of mitochondrial GSH carriers and were mostly due to higher substrate supply. Although there are few clear indicators of oxidative stress, there are several redox changes that occur early and change further as nephropathy progresses, highlighting the complexity of the disease. Highlights: ►Adaptive changes in renal mitochondrial and redox status in diabetic rats. ►Modest renal dysfunction even prior to onset of nephropathy. ►Elevated concentrations of mitochondrial GSH in diabetic kidneys. ►Change in GSH due partly to increased protein expression of transporter.

  4. Towards microRNA-based therapeutics for diabetic nephropathy.

    Science.gov (United States)

    Alvarez, M L; DiStefano, J K

    2013-03-01

    There is no cure for diabetic nephropathy and the molecular mechanisms underlying disease aetiology remain poorly understood. While current paradigms for clinical management of diabetic nephropathy are useful in delaying disease onset and preventing its progression, they do not do so for a significant proportion of diabetic individuals, who eventually end up developing renal failure. Thus, novel therapeutic targets are needed for the treatment and prevention of the disease. MicroRNAs (miRNAs), a class of non-coding RNAs that negatively regulate gene expression, have recently been identified as attractive targets for therapeutic intervention. It is widely recognised that dysregulation of miRNA expression or action contributes to the development of a number of different human diseases, and evidence of a role for miRNAs in the aetiology of diabetic nephropathy is emerging. The discovery that modulation of miRNA expression in vivo is feasible, combined with recent results from successful clinical trials using this technology, opens the way for future novel therapeutic applications. For instance, inhibition of miRNAs that are commonly upregulated in diabetic nephropathy decreases albuminuria and mesangial matrix accumulation in animal models, suggesting that a therapeutic agent against these molecules may help to prevent the development of diabetic nephropathy. Certain challenges, including the development of safe and reliable delivery systems, remain to be overcome before miRNA-based therapeutics become a reality. However, the findings accumulated to date, in conjunction with newly emerging results, are expected to yield novel insights into the complex pathogenesis of diabetic nephropathy, and may eventually lead to the identification of improved therapeutic targets for treatment of this disease.

  5. Balkan Türk Ağızlarının Tasnifleri Üzerine Bir Değerlendirme An Assessment On Classification Of Balkan Turkish Dialects

    Directory of Open Access Journals (Sweden)

    Ahmet GÜNŞEN

    2012-01-01

    Full Text Available Balkan Turkish dialects are the dialects established in varioushistorical, geographical, social and cultural conditions by the Turks,who had been moved from Anatolian and settled in the Balkans fromthe mid 14th century.Balkan Turkish dialects, just like Anatolian dialects, have hadnumber of branches due to the fact that they belonged to differentTurkish tribes and lived within various political, social, cultural andgeographical conditions on the one hand and interacted with differentlanguages and cultures, mainly like Slavic ones, on the other.The ultimate objective of the researches on dialects, which havegained great significance nowadays, is to classify the existing dialects ina certain geography of language upon certain criteria within themselvesand even within the sub-dialects and eventually to form the atlases ofthe dialects. While the Western countries and some Turkish states havetaken great steps in this field, unfortunately it is hard to say the samefor the dialects of Turkey Turkish yet. Although the classificationproblem of the dialects of Turkey Turkish has widely been solved afterquite a long process, it is yet not possible to argue the same for BalkanTurkish dialects. The researches on Balkan Turkish dialects startedwith compilations of I. Kunos and the researches of T. Kowalski andthere have been some classification attempts later by mainly J. Németh,D. Gacanov, G. Hazai, M. Mollava and I. Dryga. However it is too earlyto claim that the last word has been spoken out on this matter yet.There are still a lot to do with Balkan Turkish dialects which are lessresearchescompared to Anatolian dialects.In this paper the researches on Balkan Turkish dialects up thepresent day is going to be introduced, the basic criteria and thecommon and differing criteria used by the researchers who made theclassification is going to be assessed and finally it is going to bediscussed whether some other criteria can be used for the mainstreamdialect

  6. Distribution of Mycobacterium ulcerans in buruli ulcer endemic and non-endemic aquatic sites in Ghana.

    Directory of Open Access Journals (Sweden)

    Heather R Williamson

    Full Text Available Mycobacterium ulcerans, the causative agent of Buruli ulcer, is an emerging environmental bacterium in Australia and West Africa. The primary risk factor associated with Buruli ulcer is proximity to slow moving water. Environmental constraints for disease are shown by the absence of infection in arid regions of infected countries. A particularly mysterious aspect of Buruli ulcer is the fact that endemic and non-endemic villages may be only a few kilometers apart within the same watershed. Recent studies suggest that aquatic invertebrate species may serve as reservoirs for M. ulcerans, although transmission pathways remain unknown. Systematic studies of the distribution of M. ulcerans in the environment using standard ecological methods have not been reported. Here we present results from the first study based on random sampling of endemic and non-endemic sites. In this study PCR-based methods, along with biofilm collections, have been used to map the presence of M. ulcerans within 26 aquatic sites in Ghana. Results suggest that M. ulcerans is present in both endemic and non-endemic sites and that variable number tandem repeat (VNTR profiling can be used to follow chains of transmission from the environment to humans. Our results suggesting that the distribution of M. ulcerans is far broader than the distribution of human disease is characteristic of environmental pathogens. These findings imply that focal demography, along with patterns of human water contact, may play a major role in transmission of Buruli ulcer.

  7. On the distribution of Cerastium smolikanum (Caryophyllaceae) and Centaurea vlachorum (Asteraceae) in the Balkan Peninsula

    DEFF Research Database (Denmark)

    Shuka, Lulezim; Tan, Kit

    2009-01-01

    Cerastium smolikanum (Caryophyllaceae) and Centaurea vlachorum (Asteraceae) are reported for the first () and () are reported for the first time in C and NE Albania. These two taxa were previously considered serpentine endemics restricted to a few localities in NW Greece and the extension...

  8. Geographic patterns of endemic seed plant genera diversity in China

    OpenAIRE

    Shengbin Chen; Zhiyun Ouyang; Yu Fang; Zhenji Li

    2011-01-01

    Endemism describes the phenomenon that the distribution of individual species/taxa is critically restricted to a specific region. Seed plant genera endemic to China (endemic genera) are those with their main geographic distribution range within the borders of China. The geographic patterns of endemic genera can not only guide conservation planning, but these organisms are also important biological resources. We gath-ered data of 173 localities on environmental and spatial factors, and regiona...

  9. Features and distribution patterns of Chinese endemic seed plant species

    Institute of Scientific and Technical Information of China (English)

    Ji-Hong HUANG; Jian-Hua CHEN; Jun-Sheng YING; Ke-Ping MA

    2011-01-01

    We compiled and identified a list of Chinese. endemic seed plant species based on a large number of published References and expert reviews. The characters of these seed plant species and their distribution patterns were described at length. China is rich in endemic seed plants, with a total of 14 939 species (accounting for 52.1%of its total seed plant species) belonging to 1584 genera and 191 families. Temperate families and genera have a significantly higher proportion of endemism than cosmopolitan and tropical ones. The most primitive and derived groups have significantly higher endemism than the other groups. The endemism of tree, shrub, and liana or vine is higher than that of total species; in contrast, the endemism of herb is lower than that of total species. Geographically,these Chinese endemic plants are mainly distributed in Yunnan and Sichuan provinces, southwest China. Species richness and proportion of these endemic plants decrease with increased latitude and have a unimodal response to altitude. The peak value of proportion of endemism is at higher altitudes than that of total species and endemic species richness. The proportions of endemic shrub, liana or vine, and herb increase with altitude and have a clear unimodal curve. In contrast, the proportion of tree increases with altitude, with a sudden increase at~4000 m and has a completely different model. To date, our study provides the most comprehensive list of Chinese endemic seed plant species and their basic composition and distribution features.

  10. Metadherin facilitates podocyte apoptosis in diabetic nephropathy

    Science.gov (United States)

    Liu, Wen-Ting; Peng, Fen-Fen; Li, Hong-Yu; Chen, Xiao-Wen; Gong, Wang-Qiu; Chen, Wen-Jing; Chen, Yi-Hua; Li, Pei-Lin; Li, Shu-Ting; Xu, Zhao-Zhong; Long, Hai-Bo

    2016-01-01

    Apoptosis, one of the major causes of podocyte loss, has been reported to have a vital role in diabetic nephropathy (DN) pathogenesis, and understanding the mechanisms underlying the regulation of podocyte apoptosis is crucial. Metadherin (MTDH) is an important oncogene, which is overexpressed in most cancers and responsible for apoptosis, metastasis, and poor patient survival. Here we show that the expression levels of Mtdh and phosphorylated p38 mitogen-activated protein kinase (MAPK) are significantly increased, whereas those of the microRNA-30 family members (miR-30s) are considerably reduced in the glomeruli of DN rat model and in high glucose (HG)-induced conditionally immortalized mouse podocytes (MPC5). These levels are positively correlated with podocyte apoptosis rate. The inhibition of Mtdh expression, using small interfering RNA, but not Mtdh overexpression, was shown to inhibit HG-induced MPC5 apoptosis and p38 MAPK pathway, and Bax and cleaved caspase 3 expression. This was shown to be similar to the effects of p38 MAPK inhibitor (SB203580). Furthermore, luciferase assay results demonstrated that Mtdh represents the target of miR-30s. Transient transfection experiments, using miR-30 microRNA (miRNA) inhibitors, led to the increase in Mtdh expression and induced the apoptosis of MPC5, whereas the treatment with miR-30 miRNA mimics led to the reduction in Mtdh expression and apoptosis of HG-induced MPC5 cells in comparison with their respective controls. Our results demonstrate that Mtdh is a potent modulator of podocyte apoptosis, and that it represents the target of miR-30 miRNAs, facilitating podocyte apoptosis through the activation of HG-induced p38 MAPK-dependent pathway. PMID:27882943

  11. Apelin retards the progression of diabetic nephropathy.

    Science.gov (United States)

    Day, Robert T; Cavaglieri, Rita C; Feliers, Denis

    2013-03-15

    Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our objective was to study the effect of apelin on the progression of kidney disease in mice with established type 1 diabetes. Ove26 mice with type 1 diabetes received daily subcutaneous injections of apelin for 2 or 14 wk. APJ localizes in the glomeruli and blood vessels of kidneys. Renal APJ expression was reduced in diabetic mice but increased after treatment with apelin. Apelin treatment did not affect glycemia, body weight, or blood pressure in diabetic mice. Whole kidney and glomerular hypertrophy, as well as renal inflammation, including monocyte chemoattractant protein 1 and vascular cell adhesion molecule 1 expression, NF-κB activation, and monocyte infiltration, was inhibited after short and long treatment with apelin. Apelin administration significantly reduced albuminuria at 6 mo. Short treatment with apelin was sufficient to reverse the downregulation of the antioxidant enzyme catalase. Expression of angiotensin II and angiotensin type 1 receptor (AT1) in kidneys from diabetic mice treated was not affected by apelin. These findings show for the first time that apelin exerts a protective effect on the diabetic kidney. Short administration is sufficient to reduce kidney and glomerular hypertrophy as well as renal inflammation, but prolonged treatment is required to improve albuminuria. This effect was independent of the activation of the renin angiotensin system but correlated with upregulation of the antioxidant catalase. Apelin may represent a novel tool to treat diabetic nephropathy.

  12. Prevention of iodinated contrast-induced nephropathy

    Institute of Scientific and Technical Information of China (English)

    LI Jian-hua; HE Neng-shu

    2011-01-01

    Objective To lessen the occurrence of contrast-induced nephropathy (CIN),the preventive measures of CIN were reviewed.Data sources The data used in this review were from PubMed with relevant English articles and from Chinese Knowledge Information (CNKI) published from 1989 to 2009.The search terms were “contrast medium”,“contrast-induced nephropathy” and “prevention”.Articles involved in prevention of CIN were selected.Study selection CIN is the third most common cause of acute kidney injury and is associated with an unfavorable prognosis.The best treatment is prophylaxis because CIN can not be reversed or ameliorated.Results Thirty articles were included.Among various preventive measures,pericatheterization hydration is almost universally accepted as an appropriate and safe measure to prevent CIN,although there is no agreement as to composition,amount,and timing of hydration.Based on the use of concomitant nephrotoxic agents or high doses of contrast medium (CM) is one of risk factors for CIN,discontinuation of potentially nephrotoxic drugs 2-3 days before and after the procedure until renal function recover,and using the lowest possible dose of CM can decrease the risk of CIN.It is promising that removing the majority of CM from the coronary sinus,before it enters the systemic circulation,during coronary angiography can reduce the risk for CIN in animal studies and in limited clinical trials.Inconsistent data exist with respect to application of some vasodilators (endothelin antagonists and adenosine antagonists) and antioxidants (N-acetylcysteine and statins) in preventing CIN in high-risk patients,and new vasodilators and antioxidants continue to be tested.Conclusions Pericatheterization hydration,discontinuation of nephrotoxic drugs,and using the lowest possible dose of CM are effective measures to lessen the risk for CIN.Other prophylactic strategies and some drugs are promising,but further confirmation is required.

  13. Development of New Microsatellite Markers for Salvia officinalis L. and Its Potential Use in Conservation-Genetic Studies of Narrow Endemic Salvia brachyodon Vandas

    Directory of Open Access Journals (Sweden)

    Ivan Radosavljević

    2012-09-01

    Full Text Available Nine new microsatellite markers (SSR were isolated from Salvia officinalis L. A total of 125 alleles, with 8 to 21 alleles per locus, were detected in a natural population from the east Adriatic coast. The observed heterozygosity, expected heterozygosity, and polymorphic information content ranged from 0.46 to 0.83, 0.73 to 0.93 and 0.70 to 0.92, respectively. New microsatellite markers, as well as previously published markers, were tested for cross-amplification in Salvia brachyodon Vandas, a narrow endemic species known to be present in only two localities on the Balkan Peninsula. Out of 30 microsatellite markers tested on the natural S. brachyodon population, 15 were successfully amplified. To obtain evidence of recent bottleneck events in the populations of both species, observed genetic diversity (HE was compared to the expected genetic diversity at mutation-drift equilibrium (HEQ and calculated from the observed number of alleles using a two-phased mutation model (TPM. Recent bottleneck events were detected only in the S. brachyodon population. This result suggests the need to reconsider the current threat category of this endemic species.

  14. Development of new microsatellite markers for Salvia officinalis L. and its potential use in conservation-genetic studies of narrow endemic Salvia brachyodon Vandas.

    Science.gov (United States)

    Radosavljević, Ivan; Satovic, Zlatko; Jakse, Jernej; Javornik, Branka; Greguraš, Danijela; Jug-Dujaković, Marija; Liber, Zlatko

    2012-01-01

    Nine new microsatellite markers (SSR) were isolated from Salvia officinalis L. A total of 125 alleles, with 8 to 21 alleles per locus, were detected in a natural population from the east Adriatic coast. The observed heterozygosity, expected heterozygosity, and polymorphic information content ranged from 0.46 to 0.83, 0.73 to 0.93 and 0.70 to 0.92, respectively. New microsatellite markers, as well as previously published markers, were tested for cross-amplification in Salvia brachyodon Vandas, a narrow endemic species known to be present in only two localities on the Balkan Peninsula. Out of 30 microsatellite markers tested on the natural S. brachyodon population, 15 were successfully amplified. To obtain evidence of recent bottleneck events in the populations of both species, observed genetic diversity (H(E)) was compared to the expected genetic diversity at mutation-drift equilibrium (H(EQ)) and calculated from the observed number of alleles using a two-phased mutation model (TPM). Recent bottleneck events were detected only in the S. brachyodon population. This result suggests the need to reconsider the current threat category of this endemic species.

  15. Economic development in the European super-periphery: Evidence from the Western Balkans

    Directory of Open Access Journals (Sweden)

    Bartlett Will

    2009-01-01

    Full Text Available This paper argues that the conflicts that afflicted the Western Balkan region in the 1990s pushed the countries into the European 'super-periphery', characterized by deindustrialization and high unemployment, ethnic and regional fragmentation, political turmoil, and instability. Integration into international trade has been disrupted, leading to chronic balance of payments deficits. Low inflows of international capital, due to high country risk, have hindered technological catch-up and weakened international competitiveness. An unattractive environment for productive entrepreneurship has created barriers to the entry of SMEs, and at the same time large informal economies. Several countries have become labour-export economies, with significant outflows of skilled labour. Economic development follows a low-skill growth path. The current global economic crisis is having a further deleterious effect as export revenues, foreign direct investment, and labour remittances all diminish. Furthermore, as transition has proceeded, disparities between capital cities and rural areas have increased, while weak administrative capacities have hindered the implementation of effective local development policies to counteract these effects. Endogenous local development cannot provide an alternative to greater engagement with the global economy. The conclusion is that the countries of the region have been left out of the most beneficial elements of the globalisation process, while simultaneously suffering from its main defects. Without a faster process of accession to the EU, local disparities are likely to widen, and the region may remain within the European super-periphery for the foreseeable future.

  16. Botryosphaeriaceae associated with the die-back of ornamental trees in the Western Balkans.

    Science.gov (United States)

    Zlatković, Milica; Keča, Nenad; Wingfield, Michael J; Jami, Fahimeh; Slippers, Bernard

    2016-04-01

    Extensive die-back and mortality of various ornamental trees and shrubs has been observed in parts of the Western Balkans region during the past decade. The disease symptoms have been typical of those caused by pathogens residing in the Botryosphaeriaceae. The aims of this study were to isolate and characterize Botryosphaeriaceae species associated with diseased ornamental trees in Serbia, Montenegro, Bosnia and Herzegovina. Isolates were initially characterized based on the DNA sequence data for the internal transcribed spacer rDNA and six major clades were identified. Representative isolates from each clade were further characterized using DNA sequence data for the translation elongation factor 1-alpha, β-tubulin-2 and large subunit rRNA gene regions, as well as the morphology of the asexual morphs. Ten species of the Botryosphaeriaceae were identified of which eight, i.e., Dothiorella sarmentorum, Neofusicoccum parvum, Botryosphaeria dothidea, Phaeobotryon cupressi, Sphaeropsis visci, Diplodia seriata, D. sapinea and D. mutila were known taxa. The remaining two species could be identified only as Dothiorella spp. Dichomera syn-asexual morphs of D. sapinea, Dothiorella sp. 2 and B. dothidea, as well as unique morphological characters for a number of the known species are described. Based on host plants and geographic distribution, the majority of Botryosphaeriaceae species found represent new records. The results of this study contribute to our knowledge of the distribution, host associations and impacts of these fungi on trees in urban environments.

  17. Size-segregated concentration of heavy metals in an urban aerosol of the Balkans region (Belgrade

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    Đorđević D.

    2013-04-01

    Full Text Available This work focuses on the heavy metals contents of the size-segregated urban aerosol of the continental area of Balkans. The distribution of nano/micron heavy metals in the size-segregated urban aerosol of Belgrade center was studied during the summer–autumn of 2008. The particle size distribution in the size ranges Dp ≤ 0.49 μm, 0.49 ≤ Dp ≤ 0.95 μm, 0.95 ≤ Dp ≤ 1.5 μm, 1.5 ≤ Dp ≤ 3.0 μm, 3.0 ≤ Dp ≤ 7.2 μm and Dp ≥ 7.2 μm was measured. The aerosol samples were submitted to gravimetric and chemical analyses. The obtained mean mass concentration of the PM fractions was in accordance with an urban aerosol distribution. The aerosol mass concentrations were determined by gravimetric measurements (mGM and, for heavy metals analyzed by ICP/MS.

  18. Environmental changes on the Balkans recorded in the sediments from lakes Prespa and Ohrid

    Directory of Open Access Journals (Sweden)

    B. Wagner

    2010-05-01

    Full Text Available Lakes Prespa and Ohrid on the Balkans are considered to be amongst the oldest lakes in Europe. Both lakes are hydraulically connected via karst aquifers. From Lake Ohrid, several up to ca. 15 m long sediment records were studied during the past years. In this study, a first long sediment record from Lake Prespa was studied in order to shed more light on the influence of Lake Prespa on Lake Ohrid and the environmental history of the region. Radiocarbon dating and the occurrence of 3 dated tephra layers provide a good age control and indicate that the 10.5 m long sediment record reaches back to 48 ka. The comparison of the results from this study with those from former studies of the Lake Ohrid cores indicates that Lake Prespa is more susceptible to environmental changes due to its lower volume and water depth. Glacial sedimentation is characterized by low organic matter contents and absence of carbonates in the sediments, which indicate oligotrophic conditions in both lakes. Holocene sedimentation is characterized by particularly high carbonate contents in Lake Ohrid and by particularly high organic matter contents in Lake Prespa, which indicate a shift towards more mesotrophic conditions in the latter. Long-term environmental changes and short-term events, such as the Heinrich events during the Pleistocene or the 8.2 cooling event during the Holocene, are well recorded in both lakes, but partly expressed in different proxies.

  19. Molecular detection and prevalence of Theileria equi and Babesia caballi in horses of central Balkan.

    Science.gov (United States)

    Davitkov, Darko; Vucicevic, Milos; Stevanovic, Jevrosima; Krstic, Vanja; Slijepcevic, Dajana; Glavinic, Uros; Stanimirovic, Zoran

    2016-03-01

    Equine piroplasmosis is significant tick-borne disease with wide distribution. The prevalence of equine piroplasmosis in Serbia, Montenegro and Bosnia and Herzegovina is unknown. In aim to obtain a first insight into the prevalence we performed molecular epidemiological study which included 142 horses, on seven locations in these three countries. We first performed PCR for the detection of a 450bp long section of the 18S rRNA of piroplasma-specific region. For all positive samples we have done multiplex PCR for the species detection. Species determination was further confirmed by sequencing PCR products of 10 randomly selected Theileria equi and all Babesia caballi samples. The overall prevalence rates in analysed region for T. equi and B. caballi were 22.5% and 2.1%, respectively. Possible risk factors (such as location, age, sex and activity) associated with PCR positivity were evaluated. Marked differences were found in prevalence between geographic areas. There was no significant association between positivity and age group. T. equi was more prevalent in females and farming horses. This is the first report on the molecular survey of T. equi and B. caballi in central Balkan. Further prevalence studies on definitive host and vectors in this region are necessary.

  20. Genome size and base composition of five Pinus species from the Balkan region.

    Science.gov (United States)

    Bogunic, F; Muratovic, E; Brown, S C; Siljak-Yakovlev, S

    2003-08-01

    The 2C DNA content and base composition of five Pinus (2 n=24) species and two Pinus subspecies from the Balkan region have been estimated by flow cytometry. P. heldreichii (five populations) and P. peuce (one population) were assessed for the first time, as also were subspecies of P. nigra (three populations-two of subspecies nigra and one of subspecies dalmatica) along with P. sylvestris, and P. mugo from the same region. The 2C DNA values of these Pinus ranged from 42.5 pg to 54.9 pg (41.7-53.8 x 10(9)bp), and the base composition was quite stable (about 39.5% GC). Significant differences were observed between two subspecies of P. nigra and even between two populations of subsp. nigra. The two other species (P. sylvestris and P. mugo) had 2C values of 42.5 pg and 42.8 pg, respectively, while that of P. peuce was 54.9 pg. These genome sizes are in accordance with published values except for P. sylvestris, which was 20% below estimates made by other authors.

  1. Building Sustainable Industrial Areas: Experience and Perspectives from the Mediterranean and Western Balkan Countries

    Directory of Open Access Journals (Sweden)

    R. Preka

    2013-04-01

    Full Text Available An EU research project (Mediterranean Eco-Industrial Development, (MEID whichinvolves different actors from Mediterranean and Western Balkans region, is currently inprogress. Its general objective is to provide innovative management figures and a decisionsupport tool (model to plan, build and manage more competitive Sustainable IndustrialAreas (SIA in the involved region.In order to correspond to a coherent solution, an accurate research has been performed.The methodology implemented to detect the main issues under survey has been a SWOTanalysis of several target IAs.Following its results, there have been defined the most relevant aspects aiming atsustainability of IAs in the area. The model introduces or encourages the continuousimprovement of environmental performances of the Mediterranean industrial areas in thefollowing fields: integrating production and dismissal of solid wastes, energy saving anduse of renewable energies, reducing water consumption, better viability and avoid thedeposit of dangerous material. Thanks to this “green approach”, SMEs will be the finalbeneficiaries, fostered to eco-innovation, competitiveness and transnational cooperation.This paper presents the general context and results of the MEID project.

  2. The Impact of Foreign Direct Investment on the Export Performance: Empirical Evidence for Western Balkan Countries

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Nasir Selimi

    2016-07-01

    Full Text Available Recently there are many authors that have studied and analyzed the impact of foreign direct investments (FDI on the export performance. They have different opinions about the effect of foreign direct investments on the export performance. Some of them in their papers conclude that FDI have positive effect on the export performance and some not. There are also findings that FDI do not have any impact on the export performance. Of course for economic benefit of host country it is not important only the amount of FDI, but also their structure. To measure the effect of FDI on the export performance is not easy. Therefore, the main objective of this paper is to analyze empirically the foreign direct investments and exports performance during the period of 1996-2013 in Western Balkan countries. The paper also investigates for the fixed effects and individual heterogeneity across countries and years. Based on the panel regression techniques and Least Square Dummy Variable (LSDV regression method, FDI positively affect export performance in the sample countries in various model specifications. The results and conclusions of this paper we hope that will help everybody who are interested and studying this matter, especially the policy makers.  The last ones have the obligation to facilitate and promote the export if they award confirm that FDI contribute on developing their economy.

  3. Foreign direct investment in the western Balkans: Privatization, institutional change, and banking sector dominance

    Directory of Open Access Journals (Sweden)

    Botrić Valerija

    2010-01-01

    Full Text Available The paper provides analysis of foreign direct investment (FDI dynamics and its determinants for the group of countries lately referred to as Western Balkans (non- EU ex-Yugoslavia countries plus Albania. Due to vulnerable external positions and enhanced funding requirements related to the EU accession and catching-up, FDI is often highly welcomed by government officials in the South East European (SEE countries. The notion that FDI is frequently accompanied by knowledge and know-how transfer makes this source of capital growth even more desirable than simple capital accumulation from frequently inadequate domestic savings. The analysis of the FDI determinants on the overall economy level conducted within the panel data framework aims to provide the answer whether the same factors as in Central and Eastern European countries, now new EU member states, are relevant for the sampled countries. Due to data limitations and the frequent emergence of new countries in the region, the analysis does not extend to the early transition period. Since it entails the beginning of the financial crisis, the comparison of the results obtained with those of previous studies will enable the discussion of internal versus external factors of FDI attraction in the region.

  4. Do GCI indicators predict SME creation? A Western Balkans cross-country comparative analysis

    Directory of Open Access Journals (Sweden)

    Fëllënza Lushaku

    2016-03-01

    Full Text Available In early stages SMEs were seen as insignificant supplement to large business supply, whereas today they have a very important social and economic role, because of their contribution to job creation. These contributions are very valuable in times of crises and rising unemployment. In Kosovo and the Western Balkan countries, including countries such as Albania, Macedonia, Montenegro, Serbia and Bosnia and Herzegovina, the development of SMEs can contribute in facing many challenges, effects of inequality, high level of unemployment and demographic challenges. In addition, SME development can contribute to strengthening the competitiveness and productivity, while also promoting the growth of income per capita. Besides the positive perception the creation of small and medium enterprises has, it is also indispensable to consider their extinction rate, being the most affected category of businesses, especially in the initial stages. It is proved that the net SME creation and cross-country differences in the relationship between new businesses and extinct businesses, can serve as a recommendation for policy makers in order to create a favorable climate for small and medium enterprises. GCI indicators that measures global competitiveness are used to determine if the climate of competitiveness predicts the development of SMEs.

  5. Taenia solium in Europe: Still endemic?

    Science.gov (United States)

    Devleesschauwer, Brecht; Allepuz, Alberto; Dermauw, Veronique; Johansen, Maria V; Laranjo-González, Minerva; Smit, G Suzanne A; Sotiraki, Smaragda; Trevisan, Chiara; Wardrop, Nicola A; Dorny, Pierre; Gabriël, Sarah

    2017-01-01

    The pork tapeworm, Taenia solium, causes an important economic and health burden, mainly in rural or marginalized communities of sub-Saharan Africa, Asia, and Latin-America. Although improved pig rearing conditions seem to have eliminated the parasite in most Western European countries, little is known about the true endemicity status of T. solium throughout Europe. Three recent reviews indicate that autochthonous human T. solium taeniasis/cysticercosis may be possible in Europe, but that current peer-reviewed literature is biased towards Western Europe. Officially reported data on porcine cysticercosis are highly insufficient. Favourable conditions for local T. solium transmission still exist in eastern parts of Europe, although the ongoing integration of the European Union is speeding up modernisation and intensification of the pig sector. Further evidence is urgently needed to fill the gaps on the European T. solium endemicity map. We urge to make human cysticercosis notifiable and to improve the reporting of porcine cysticercosis.

  6. Controlling endemic cholera with oral vaccines.

    Directory of Open Access Journals (Sweden)

    Ira M Longini

    2007-11-01

    Full Text Available BACKGROUND: Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the world's most impoverished populations. Internationally licensed, killed whole-cell based oral cholera vaccines (OCVs have been available for over a decade, but have not been used for the control of cholera. Recently, these vaccines were shown to confer significant levels of herd protection, suggesting that the protective potential of these vaccines has been underestimated and that these vaccines may be highly effective in cholera control when deployed in mass immunization programs. We used a large-scale stochastic simulation model to investigate the possibility of controlling endemic cholera with OCVs. METHODS AND FINDINGS: We construct a large-scale, stochastic cholera transmission model of Matlab, Bangladesh. We find that cholera transmission could be controlled in endemic areas with 50% coverage with OCVs. At this level of coverage, the model predicts that there would be an 89% (95% confidence interval [CI] 72%-98% reduction in cholera cases among the unvaccinated, and a 93% (95% CI 82%-99% reduction overall in the entire population. Even a more modest coverage of 30% would result in a 76% (95% CI 44%-95% reduction in cholera incidence for the population area covered. For populations that have less natural immunity than the population of Matlab, 70% coverage would probably be necessary for cholera control, i.e., an annual incidence rate of < or = 1 case per 1,000 people in the population. CONCLUSIONS: Endemic cholera could be reduced to an annual incidence rate of < or = 1 case per 1,000 people in endemic areas with biennial vaccination with OCVs if coverage could reach 50%-70% depending on the level of prior immunity in the population. These vaccination efforts could be targeted with careful use of ecological data.

  7. Immunohistochemical Aspects of Cell Death in Diabetic Nephropathy

    Directory of Open Access Journals (Sweden)

    Bălăşescu Elena

    2016-03-01

    Full Text Available Introduction. Diabetes Mellitus causes ultrastructural changes triggered by partially clarified cellular mechanisms. Since cell death is an important mechanism in the appearance and progression of diabetic nephropathy, we studied alteration of several markers of apoptotic pathways signaling in renal tissue of diabetic or prediabetic patients.

  8. 15.4.Interstitial nephritis and interstitial nephropathy

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920149 The relationship between renal tis-sue subsets of lymphocytes and clinicalfeatures in IgA nephropathy.LIU Zhihong (刘志红),et al.Dept Nephrol,Jinling Hosp,Nanjing(210002).Chin J Nephrol 1991; 7 (4): 230.Amount of CD4+,CD8+ and B cells in the

  9. Case report: analgesic nephropathy: a soda and a powder.

    Science.gov (United States)

    Appel, R G; Bleyer, A J; McCabe, J C

    1995-10-01

    Analgesic nephropathy has long been considered a potentially preventable cause of renal disease. Early reports were described in patients who consumed analgesics containing phenacetin. In recent data, the removal of phenacetin from analgesic preparations resulted in a reduction in analgesic-induced end stage renal disease in Europe and Australia. However, a reduction in the incidence of analgesic nephropathy has not occurred uniformly, suggesting that phenacetin is not the sole cause. Current data raise concerns regarding adverse renal effects of acetaminophen and nonsteroidal antiinflammatory drugs. Aspirin taken alone may be of least concern. The diagnosis of analgesic nephropathy is suggested in subjects with chronic renal failure, a history of daily consumption of analgesic preparations, small bumpy kidneys, and renal papillary necrosis or chronic interstitial nephritis. However, the spectrum of disease may be changing, because these agents also may increase the risk of cardiovascular disease and chronic renal disease due to nephrosclerosis, glomerulonephritis, and diabetes mellitus. Potential pathogenetic mechanisms in analgesic nephropathy include direct cellular injury induced by analgesics, prostaglandin inhibition with reduction or redistribution of renal blood flow, and interesting new concepts regarding the role of caffeine in increasing oxygen demand and reducing oxygen supply in the medulla. The primary goal of therapy is discontinuation of analgesic consumption. Because of the association between analgesic intake and uroepithelial tumors, surveillance of patients for neoplasm is suggested.

  10. Chronic constipation causing obstructive nephropathy in a delayed toddler.

    LENUS (Irish Health Repository)

    Barrett, Michael Joseph

    2012-01-01

    Chronic constipation causing obstructive nephropathy is very rare in children. However, it can cause urinary tract obstruction with acute impairment of renal function with a need for emergent disimpaction. The authors discuss a 2 years 4 months old child who presented to our emergency department with acute renal failure due to faecal impaction.

  11. Membranous nephropathy in the older adult: epidemiology, diagnosis and management.

    NARCIS (Netherlands)

    Deegens, J.K.J.; Wetzels, J.F.M.

    2007-01-01

    Membranous nephropathy is the most important cause of the nephrotic syndrome in elderly patients (aged >65 years). The clinical presentation is similar in older and younger patients, although elderly patients more often present with renal failure. Notably, glomerular filtration rate (GFR) is usua

  12. [The role of ramipril in the therapy of diabetic nephropathy].

    Science.gov (United States)

    Dézsi, Csaba András

    2014-02-16

    In the past two decades the number of diabetic patients has increased dramatically. According to the data of the International Diabetes Federation published in 2012, more than 371 million people suffer from diabetes mellitus, which is responsible for the death of 4.8 million people yearly. Diabetic nephropathy is the most frequent cause of terminal renal failure. The first stage of its development is microalbuminuria. Without an efficient treatment 20-40% of the patients with microalbuminuria suffering from type 2 diabetes mellitus develop chronic renal failure, but only 20% of them become uremic because most of them die beforehand mainly due to cardiovascular disease. The renin-angiotensin-system, which is one of the most important elements of the regulation of blood pressure and water-salt metabolism, plays an important role in the development of diabetic nephropathy. Drugs affecting the function of this system are of great significance in the treatment of hypertension. The author rewiews the results of several important studies and animal experiments to demonstrate the role of ramipril in the therapy of diabetic nephropathy. The author concludes that ramipril is one of the angiotensin-converting enzyme inhibitors with the highest number of evidence based beneficial results. Apart from its blood pressure decreasing effect, ramipril protects target organs and it proved to be effective in the treatment of diabetic nephropathy according to most international multicenter clinical trials. Orv. Hetil., 2014, 155(7), 263-269.

  13. Current concepts in the management of diabetic nephropathy

    NARCIS (Netherlands)

    Waanders, F.; Visser, F. W.; Gans, R. O. B.

    2013-01-01

    Although much progress has been made in slowing the progression of diabetic nephropathy, renal dysfunction and development of end-stage renal disease (ESRD) remain major concerns in diabetes. In addition, diabetic patients with microalbuminuria have an increased cardiovascular mortality. Therefore,

  14. Calorie restriction mimicking effects of roflumilast prevents diabetic nephropathy.

    Science.gov (United States)

    Tikoo, Kulbhushan; Lodea, Saritha; Karpe, Pinakin Arun; Kumar, Sandeep

    2014-08-08

    Little is known about role of PDE4 in the development and progression of diabetic nephropathy. Here, we investigated the effect of roflumilast, a selective PDE 4 inhibitor in type 1 diabetic nephropathy. Diabetes was induced in male Sprague-Dawley rats using streptozotocin (55 mg/kg). Diabetic rats showed elevated plasma glucose, blood urea nitrogen, creatinine and decrease in plasma albumin confirming signs of nephropathy. Roflumilast at 2 and 3mg/kg normalized these alterations. Roflumilast also suppressed oxidative stress and deposition of an extracellular matrix protein such as fibronectin and collagen in kidney of diabetic rats. TUNEL assay revealed apoptosis in diabetic kidney than control and that roflumilast prevents this effect. We show that kidney of diabetic rats displayed a state of p-AMPK and SIRT1 deficiency and that roflumilast, interestingly, was able to restore their levels. Further, roflumilast prevented an increase in HO-1 and loss in the FoxO1 expression in diabetes. However, it did not improve the reduced NRF2 levels in diabetes. This is the first report to show that, like resveratrol and other SIRT1 activators, roflumilast also mimics calorie restriction effects through activation of AMPK/SIRT1 and protects against diabetic nephropathy. This study unveils the unexplored potential of roflumilast which can be used in treatment of metabolic disorders.

  15. Overexpression of Mafb in podocytes protects against diabetic nephropathy.

    Science.gov (United States)

    Morito, Naoki; Yoh, Keigyou; Ojima, Masami; Okamura, Midori; Nakamura, Megumi; Hamada, Michito; Shimohata, Homare; Moriguchi, Takashi; Yamagata, Kunihiro; Takahashi, Satoru

    2014-11-01

    We previously showed that the transcription factor Mafb is essential for podocyte differentiation and foot process formation. Podocytes are susceptible to injury in diabetes, and this injury leads to progression of diabetic nephropathy. In this study, we generated transgenic mice that overexpress Mafb in podocytes using the nephrin promoter/enhancer. To examine a potential pathogenetic role for Mafb in diabetic nephropathy, Mafb transgenic mice were treated with either streptozotocin or saline solution. Diabetic nephropathy was assessed by renal histology and biochemical analyses of urine and serum. Podocyte-specific overexpression of Mafb had no effect on body weight or blood glucose levels in either diabetic or control mice. Notably, albuminuria and changes in BUN levels and renal histology observed in diabetic wild-type animals were ameliorated in diabetic Mafb transgenic mice. Moreover, hyperglycemia-induced downregulation of Nephrin was mitigated in diabetic Mafb transgenic mice, and reporter assay results suggested that Mafb regulates Nephrin directly. Mafb transgenic glomeruli also overexpressed glutathione peroxidase, an antioxidative stress enzyme, and levels of the oxidative stress marker 8-hydroxydeoxyguanosine decreased in the urine of diabetic Mafb transgenic mice. Finally, Notch2 expression increased in diabetic glomeruli, and this effect was enhanced in diabetic Mafb transgenic glomeruli. These data indicate Mafb has a protective role in diabetic nephropathy through regulation of slit diaphragm proteins, antioxidative enzymes, and Notch pathways in podocytes and suggest that Mafb could be a therapeutic target.

  16. IgA nephropathy: Causes, prognosis and treatment

    Institute of Scientific and Technical Information of China (English)

    Francesco Paolo Schena; Diletta Domenica Torres; Giuseppina Cerrullo

    2005-01-01

    @@ IgA nephropathy (IgAN) or Berger's disease is the most common form of primary glomerulonephritis in many renal biopsy registries and it is very frequent in the Eastern regions of the world, such as China (32,1%), Hong Kong (35%), Japan (47,4% )[1,2].

  17. Progression of nephropathy in type 2 diabetic patients

    DEFF Research Database (Denmark)

    Rossing, Kasper; Christensen, Per Klitgaard; Hovind, Peter

    2004-01-01

    BACKGROUND: Nephropathy in type 2 diabetes is the single most common cause of end-stage renal disease (ESRD), but the decline in kidney function varies considerably between individuals, and determinants of renal function loss, early in the course of renal disease, have not been clearly identified...

  18. Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy.

    Science.gov (United States)

    Tagawa, Atsuko; Yasuda, Mako; Kume, Shinji; Yamahara, Kosuke; Nakazawa, Jun; Chin-Kanasaki, Masami; Araki, Hisazumi; Araki, Shin-Ichi; Koya, Daisuke; Asanuma, Katsuhiko; Kim, Eun-Hee; Haneda, Masakazu; Kajiwara, Nobuyuki; Hayashi, Kazuyuki; Ohashi, Hiroshi; Ugi, Satoshi; Maegawa, Hiroshi; Uzu, Takashi

    2016-03-01

    Overcoming refractory massive proteinuria remains a clinical and research issue in diabetic nephropathy. This study was designed to investigate the pathogenesis of massive proteinuria in diabetic nephropathy, with a special focus on podocyte autophagy, a system of intracellular degradation that maintains cell and organelle homeostasis, using human tissue samples and animal models. Insufficient podocyte autophagy was observed histologically in patients and rats with diabetes and massive proteinuria accompanied by podocyte loss, but not in those with no or minimal proteinuria. Podocyte-specific autophagy-deficient mice developed podocyte loss and massive proteinuria in a high-fat diet (HFD)-induced diabetic model for inducing minimal proteinuria. Interestingly, huge damaged lysosomes were found in the podocytes of diabetic rats with massive proteinuria and HFD-fed, podocyte-specific autophagy-deficient mice. Furthermore, stimulation of cultured podocytes with sera from patients and rats with diabetes and massive proteinuria impaired autophagy, resulting in lysosome dysfunction and apoptosis. These results suggest that autophagy plays a pivotal role in maintaining lysosome homeostasis in podocytes under diabetic conditions, and that its impairment is involved in the pathogenesis of podocyte loss, leading to massive proteinuria in diabetic nephropathy. These results may contribute to the development of a new therapeutic strategy for advanced diabetic nephropathy.

  19. Transforming growth factor-β in diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Karima Y. Ahmed

    2013-01-01

    Conclusion Serum TGF-β level increases in patients of both type 1 and type 2 diabetes and in those with diabetic nephropathy. TGF-β is considered one of the major mediators of diabetic renal fibrogenesis that Results in end-stage renal disease.

  20. Immunoglobulin M Nephropathy in a Patient with Wilson's Disease.

    Science.gov (United States)

    Ul Abideen, Zain; Sajjad, Zoya; Haroon Khan, Asna; Mamoon, Nadira; Bilal, Muhammad; Mujtaba Quadri, Khaja Hameeduddin

    2016-12-13

    Immunoglobulin M nephropathy (IgMN) is characterized by the deposition of immunoglobulin M in a dominant distribution in the renal glomeruli. Primary immunoglobulin M nephropathy is diagnosed after consistent light microscopy (LM), immunofluorescence (IF), electron microscopy (EM) results, and exclusion of known systemic disorders causing immunoglobulin M deposition in the glomeruli. The secondary disease has been reported with a few conditions though it has never been reported with any primary disease of the liver. We report the case of an adolescent male patient who presented with nausea, vomiting, diarrhea, and worsening anasarca. He was found to have nephrotic-range proteinuria that did not respond to conventional corticosteroid treatment. He was subjected to a renal biopsy which revealed a diagnosis of immunoglobulin M nephropathy. His liver function tests were deranged and an ultrasound scan of the abdomen revealed a coarse irregular liver. Workup revealed elevated urine copper excretion and a low ceruloplasmin level. He was diagnosed as a case of Wilson's disease and started on penicillamine and pyridoxine. He was also started on intravenous cyclophosphamide for the corticosteroid-resistant nephrotic syndrome to which he responded remarkably well. His edema settled, proteinuria resolved, and liver functions normalized. Currently, he is in remission and enjoying good health. To the best of our knowledge, we report the first known association between IgM nephropathy and Wilson's disease. It is presently not clear if causation can necessarily be established. This may be the result of defective IgM clearance by the liver or an altered metabolism of the antibody or immune complexes, as with hepatic-associated immunoglobulin M (IgM) nephropathy. Further studies are needed to elucidate the exact mechanism of this disease.

  1. The aquatic molluscs (Mollusca: Gastropoda and Bivalvia of Vrachanski Balkan Nature Park

    Directory of Open Access Journals (Sweden)

    DILIAN GEORGIEV

    2016-05-01

    Full Text Available Till now 13 species of aquatic molluscs are known to inhabit the park area: 11 species of snails and 2 species of clams. Even included in the list the species of Grossuana and Radix balthica has to be studied anatomically for sure identification. Nine species are of conservation statute classified as "Least Concern" or "Vulnerable", and four does not have any statute. Three stygobiotic snail species are local endemics.

  2. Alu insertion polymorphisms and an assessment of the genetic contribution of Central Asia to Anatolia with respect to the Balkans.

    Science.gov (United States)

    Berkman, Ceren Caner; Dinc, Havva; Sekeryapan, Ceran; Togan, Inci

    2008-05-01

    In the evolutionary history of modern humans, Anatolia acted as a bridge between the Caucasus, the Near East, and Europe. Because of its geographical location, Anatolia was subject to migrations from multiple different regions throughout time. The last, well-known migration was the movement of Turkic speaking, nomadic groups from Central Asia. They invaded Anatolia and then the language of the region was gradually replaced by the Turkic language. In the present study, insertion frequencies of 10 Alu loci (A25 = 0.07, APO = 0.96, TPA25 = 0.44, ACE = 0.37, B65 = 0.57, PV92 = 0.18, FXIIIB = 0.52, D1 = 0.40, HS4.32 = 0.66, and HS4.69 = 0.30) have been determined in the Anatolian population. Together with the data compiled from other databases, the similarity of the Anatolian population to that of the Balkans and Central Asia has been visualized by multidimensional scaling method. Analysis suggested that, genetically, Anatolia is more closely related with the Balkan populations than to the Central Asian populations. Central Asian contribution to Anatolia with respect to the Balkans was quantified with an admixture analysis. Furthermore, the association between the Central Asian contribution and the language replacement episode was examined by comparative analysis of the Central Asian contribution to Anatolia, Azerbaijan (another Turkic speaking country) and their neighbors. In the present study, the Central Asian contribution to Anatolia was estimated as 13%. This was the lowest value among the populations analyzed. This observation may be explained by Anatolia having the lowest migrant/resident ratio at the time of migrations.

  3. Potential impacts of climate change on flow regime and fish habitat in mountain rivers of the south-western Balkans.

    Science.gov (United States)

    Papadaki, Christina; Soulis, Konstantinos; Muñoz-Mas, Rafael; Martinez-Capel, Francisco; Zogaris, Stamatis; Ntoanidis, Lazaros; Dimitriou, Elias

    2016-01-01

    The climate change in the Mediterranean area is expected to have significant impacts on the aquatic ecosystems and particular in the mountain rivers and streams that often host important species such as the Salmo farioides, Karaman 1938. These impacts will most possibly affect the habitat availability for various aquatic species resulting to an essential alteration of the water requirements, either for dams or other water abstractions, in order to maintain the essential levels of ecological flow for the rivers. The main scope of this study was to assess potential climate change impacts on the hydrological patterns and typical biota for a south-western Balkan mountain river, the Acheloos. The altered flow regimes under different emission scenarios of the Intergovernmental Panel on Climate Change (IPCC) were estimated using a hydrological model and based on regional climate simulations over the study area. The Indicators of Hydrologic Alteration (IHA) methodology was then used to assess the potential streamflow alterations in the studied river due to predicted climate change conditions. A fish habitat simulation method integrating univariate habitat suitability curves and hydraulic modeling techniques were used to assess the impacts on the relationships between the aquatic biota and hydrological status utilizing a sentinel species, the West Balkan trout. The most prominent effects of the climate change scenarios depict severe flow reductions that are likely to occur especially during the summer flows, changing the duration and depressing the magnitude of the natural low flow conditions. Weighted Usable Area-flow curves indicated the limitation of suitable habitat for the native trout. Finally, this preliminary application highlighted the potential of science-based hydrological and habitat simulation approaches that are relevant to both biological quality elements (fish) and current EU Water policy to serve as efficient tools for the estimation of possible climate

  4. Effects of pregnancy on the onset and progression of diabetic nephropathy and of diabetic nephropathy on pregnancy outcomes.

    Science.gov (United States)

    Young, Esther Cytrynbaum; Pires, Maria Lucia Elias; Marques, Luiz Paulo José; de Oliveira, José Egídio Paulo; Zajdenverg, Lenita

    2011-01-01

    Controversy exists regarding the effect of pregnancy on the development and course of diabetic nephropathy. This study followed 43 pregnant women with previous diabetes mellitus, 32 without nephropathy (Group I) and 11 with nephropathy (Group II). Urinary albumin excretion (UAE), serum creatinine (Cr) and creatinine clearance (CCr) in the pre-pregnancy (Pre-P), first trimester (1T), third trimester (3T) and 1 year postpartum (PP) were evaluated. In both groups there were an increase in 3T compared to Pre-P of CCr (137 vs. 98 ml/min and 110 vs. 81 ml/min, p=0.0001, respectively) and UAE (7.78 vs. 3.15 mg/24 h and 592 vs. 119 mg/24 h, p=0.0001, respectively). Increase of Cr in the PP compared to 1T in Group II (0.88 vs. 0.70 mg/dL, p=0.031) was observed. There were no difference in UAE, CCr and Cr in the PP when compared to pre-P as well variance over time between groups. Group II showed higher prevalence of chronic hypertension (72.7 vs. 21.9%, p=0.004), preeclampsia (63.6 vs. 6.3%, p=0.0003) and lower gestational age at birth (36 vs. 38 weeks, p=0.003). We conclude that pregnancy was not associated with development and progression of diabetic nephropathy in women with or without mild renal dysfunction. The presence of diabetic nephropathy was associated with increased risk of perinatal complications.

  5. Nacionalismo e etnias em conflito nos Bálcãs The Balkans, nationalism and ethnic clashes

    Directory of Open Access Journals (Sweden)

    José Augusto Lindgren Alves

    2004-01-01

    Full Text Available O artigo resgata a história dos países balcânicos para refletir sobre o nacionalismo - uma peculiar importação da cultura política européia - e os conflitos étnicos da região, exacerbados pela reinvenção de ortodoxias religiosas desaparecidas há décadas.The article turns to the history of the Balkan, countries to think about the region's nationalism - a peculiar importation from the European political culture - and the region's ethnic conflicts, intensified by recently re-invented religious orthodoxies.

  6. The Austrian Approach in Promoting Partnership in Balkan Areas: Research Cooperation and Networking between Austria, Kosovo and South Eastern Europe

    Directory of Open Access Journals (Sweden)

    SALIH S.

    2009-12-01

    Full Text Available Creating and improving the partnerships in order to strengthen the cooperation between institutions andcontribute towards a sustainable regional scientific collaboration is of major preoccupation for the Austrian Science andBalkan areas. Permanent work in maintaining a diversity of wheat plants and cultivars is a key to survival of plants,which are undergone to the new abiotic and biotic stress (climatic condition, pests and disease demonstrates to be asuitable issue to ve approached in this aim. The partnership between four countries is developing (Austria, Kosovo,Bulgaria and Romania, in order to implement the colaboration.

  7. Comparison of the protein and fatty acid fraction of Balkan donkey and human milk

    Directory of Open Access Journals (Sweden)

    Jasmina Gubić

    2015-07-01

    Full Text Available The aim of this study was to compare the protein and fatty acid fractions of Balkan donkey and human milk in the early lactation stage (40 and 90 day. This study revealed that donkey milk contains αs1-casein (1.38-1.89 g/L and higher concentration of β-casein (0.1-0.55 g/L in comparison to human milk. The concentration of α-lactalbumin increased during the lactation phases from 40 to 90 days in both types of milk. Donkey milk contained β-lactoglobulin in low concentrations which decreased to 90th day of lactation. Donkey milk was particularly rich in two whey proteins, lactoferrin and lysozyme, which were found to have molecular weight of approximately 76 kDa and 14.9-15.4 kDa, respectively. The content of lysozyme in donkey milk ranged from 2.39 to 2.97 g/L, while human milk contained 30-50 times lower concentrations of lysozyme in comparison to donkey milk. Thus, donkey milk contained also a higher concentration of lactoferrin (0.012-0.25 g/L than it was found in the human milk. Lysozyme and lactoferrin content in donkey milk increased during the period from 40th to 90th day of lactation. The percentage of total SFA, MUFA and PUFA was similar in donkey and human milk. The content of essential fatty acids increased during 40-90 days of lactation and was approximately 2.5 times higher in comparison to human milk.

  8. Tectonic, magmatic, and metallogenic evolution of the Late Cretaceous arc in the Carpathian-Balkan orogen

    Science.gov (United States)

    Gallhofer, Daniela; Quadt, Albrecht von; Peytcheva, Irena; Schmid, Stefan M.; Heinrich, Christoph A.

    2015-09-01

    The Apuseni-Banat-Timok-Srednogorie Late Cretaceous magmatic arc in the Carpathian-Balkan orogen formed on the European margin during closure of the Neotethys Ocean. It was subsequently deformed into a complex orocline by continental collisions. The Cu-Au mineralized arc consists of geologically distinct segments: the Apuseni, Banat, Timok, Panagyurishte, and Eastern Srednogorie segments. New U-Pb zircon ages and geochemical whole rock data for the Banat and Apuseni segments are combined with previously published data to reconstruct the original arc geometry and better constrain its tectonic evolution. Trace element and isotopic signatures of the arc magmas indicate a subduction-enriched source in all segments and variable contamination by continental crust. The magmatic arc was active for 25 Myr (~92-67 Ma). Across-arc age trends of progressively younger ages toward the inferred paleo-trench indicate gradual steepening of the subducting slab away from the upper plate European margin. This leads to asthenospheric corner flow in the overriding plate, which is recorded by decreasing 87Sr/86Sr (0.70577 to 0.70373) and increasing 143Nd/144Nd (0.51234 to 0.51264) ratios over time in some segments. The close spatial relationship between arc magmatism, large-scale shear zones, and related strike-slip sedimentary basins in the Timok and Pangyurishte segments indicates mild transtension in these central segments of the restored arc. In contrast, the Eastern Srednogorie segment underwent strong orthogonal intraarc extension. Segmental distribution of tectonic stress may account for the concentration of rich porphyry Cu deposits in the transtensional segments, where lower crustal magma storage and fractionation favored the evolution of volatile-rich magmas.

  9. Morphological variability of Fraxinus angustifolia Vahl in the north-western Balkans

    Directory of Open Access Journals (Sweden)

    Kristjan Jarni

    2011-08-01

    Full Text Available Fraxinus angustifolia Vahl is a species native in the north-western Balkans, where it has a divided range. Most of its range is located in flood-prone riparian sites in the Pannonian plain but the species is also found on humid sites along some rivers in the Submediterranean region. We analysed morphologic variation within and between five populations (14 trees/population located in the Subpannonian and Submediterranean region of Slovenia. Thirty two characters were assessed on ca. 80 leaves from each tree which were divided depending on exposure to sunlight (sun and shade leaves, and 8 traits on each fruit (ca. 50 fruits/tree. A hierarchically designed experiment using analysis of variance confirmed the significant contribution of all the analysed hierarchical levels of variation to the total variation. The results show that the differences between the trees in a single population are the greatest factor of variability of leaves, followed by differences between populations and differences which are the result of variation in exposure to sunlight. Leaves in shade positions are typically larger than those in sunny positions, and they have broader and shorter-pointed leaflets; in this feature they are very similar to the leaves of F. excelsior. Stepwise discriminant analysis showed that the traits which refer to the leaflet number and length are the best differentiating traits between individual populations. The Submediterranean population Dragonja stands out with the smallest leaves and the population Lijak from the same region is the most similar to Dragonja for most morphological traits. In general, phenotypic differences between the Subpannonian and the Submediterranean populations of F. angustifolia are minor and indistinct. Based on the differences ascertained by the study, we can only confirm the presence of F. angustifolia subsp. oxycarpa (Bieb. ex Willd. Franco et Rocha Alfonso in this part of its natural range.

  10. Balkanized Research in Ecological Engineering Revealed by a Bibliometric Analysis of Earthworms and Ecosystem Services

    Science.gov (United States)

    Blouin, Manuel; Sery, Nicolas; Cluzeau, Daniel; Brun, Jean-Jacques; Bédécarrats, Alain

    2013-08-01

    Energy crisis, climate changes, and biodiversity losses have reinforced the drive for more ecologically-based approaches for environmental management. Such approaches are characterized by the use of organisms rather than energy-consuming technologies. Although earthworms are believed to be potentially useful organisms for managing ecosystem services, there is actually no quantification of such a trend in literature. This bibliometric analysis aimed to measure the evolution of the association of "earthworms" and other terms such as ecosystem services (primary production, nutrient cycling, carbon sequestration, soil structure, and pollution remediation), "ecological engineering" or "biodiversity," to assess their convergence or divergence through time. In this aim, we calculated the similarity index, an indicator of the paradigmatic proximity defined in applied epistemology, for each year between 1900 and 2009. We documented the scientific fields and the geographical origins of the studies, as well as the land uses, and compare these characteristics with a 25 years old review on earthworm management. The association of earthworm related keywords with ecosystem services related keywords was increasing with time, reflecting the growing interest in earthworm use in biodiversity and ecosystem services management. Conversely, no significant increase in the association between earthworms and disciplines such as ecological engineering or restoration ecology was observed. This demonstrated that general ecologically-based approaches have yet to emerge and that there is little exchange of knowledge, methods or concepts among balkanized application realms. Nevertheless, there is a strong need for crossing the frontiers between fields of application and for developing an umbrella discipline to provide a framework for the use of organisms to manage ecosystem services.

  11. Balkanized research in ecological engineering revealed by a bibliometric analysis of earthworms and ecosystem services.

    Science.gov (United States)

    Blouin, Manuel; Sery, Nicolas; Cluzeau, Daniel; Brun, Jean-Jacques; Bédécarrats, Alain

    2013-08-01

    Energy crisis, climate changes, and biodiversity losses have reinforced the drive for more ecologically-based approaches for environmental management. Such approaches are characterized by the use of organisms rather than energy-consuming technologies. Although earthworms are believed to be potentially useful organisms for managing ecosystem services, there is actually no quantification of such a trend in literature. This bibliometric analysis aimed to measure the evolution of the association of "earthworms" and other terms such as ecosystem services (primary production, nutrient cycling, carbon sequestration, soil structure, and pollution remediation), "ecological engineering" or "biodiversity," to assess their convergence or divergence through time. In this aim, we calculated the similarity index, an indicator of the paradigmatic proximity defined in applied epistemology, for each year between 1900 and 2009. We documented the scientific fields and the geographical origins of the studies, as well as the land uses, and compare these characteristics with a 25 years old review on earthworm management. The association of earthworm related keywords with ecosystem services related keywords was increasing with time, reflecting the growing interest in earthworm use in biodiversity and ecosystem services management. Conversely, no significant increase in the association between earthworms and disciplines such as ecological engineering or restoration ecology was observed. This demonstrated that general ecologically-based approaches have yet to emerge and that there is little exchange of knowledge, methods or concepts among balkanized application realms. Nevertheless, there is a strong need for crossing the frontiers between fields of application and for developing an umbrella discipline to provide a framework for the use of organisms to manage ecosystem services.

  12. Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population

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    Danfeng Peng

    2014-01-01

    Full Text Available Objective. Toll-like receptor 4 (TLR4 plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. Methods. Seven tagging single nucleotide polymorphisms (SNPs of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy. Results. None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either. Conclusion. We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.

  13. The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment.

    Science.gov (United States)

    Elsherbiny, Nehal M; Al-Gayyar, Mohammed M H

    2016-05-01

    Diabetic vascular complication is a leading cause of diabetic nephropathy, a progressive increase in urinary albumin excretion coupled with elevated blood pressure leading to declined glomerular filtration and eventually end stage renal failure. There is growing evidence that activated inflammation is contributing factor to the pathogenesis of diabetic nephropathy. Meanwhile, IL-18, a member of the IL-1 family of inflammatory cytokines, is involved in the development and progression of diabetic nephropathy. However, the benefits derived from the current therapeutics for diabetic nephropathy strategies still provide imperfect protection against renal progression. This imperfection points to the need for newer therapeutic agents that have potential to affect primary mechanisms contributing to the pathogenesis of diabetic nephropathy. Therefore, the recognition of IL-18 as significant pathogenic mediators in diabetic nephropathy leaves open the possibility of new potential therapeutic targets.

  14. Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy

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    Michio Ohtsuji

    2008-01-01

    Results. ADPRCA negatively correlated with the level of HbA1c (=.040, 2=.073, although ADPRCA showed no significant correlation with gender, age, BMI, blood pressure, level of fasting plasma glucose and lipid levels, as well as type, duration, or medication of diabetes. Interestingly, patients with nephropathy, but not other complications, presented significantly lower ADPRCA than those without nephropathy (=.0198 and diabetes (=.0332. ANCOVA analysis adjusted for HbA1c showed no significant correlation between ADPRCA and nephropathy. However, logistic regression analyses revealed that determinants for nephropathy were systolic blood pressure and ADPRCA, not HbA1c. Conclusion/interpretation. Decreased ADPRCA significantly correlated with diabetic nephropathy. ADPRCA in PBMCs would be an important marker associated with diabetic nephropathy.

  15. Nephropathy in type 1 diabetes is associated with increased circulating activated platelets and platelet hyperreactivity

    DEFF Research Database (Denmark)

    Tarnow, Inge; Michelson, Alan D.; Barnard, Marc R.;

    2009-01-01

    Patients with diabetes mellitus (DM) have increased platelet activation compared to non-diabetic controls. Platelet hyperreactivity has been associated with adverse cardiovascular outcomes in Type 2 DM, and with diabetic nephropathy. We investigated the relationship between platelet activation...... and nephropathy in Type 1 DM. Patients with Type 1 DM and diabetic nephropathy (n = 35), age- and sex-matched Type 1 DM patients with persistent normoalbuminuria (n = 51), and healthy age- and sex-matched controls (n = 30) were studied. Platelet surface P-selectin, platelet surface activated GPIIb/IIIa, monocyte...... to 0.5 or 20 microM ADP) was higher in nephropathy patients compared with normoalbuminuric patients (P = 0.027), and non-diabetic controls (P = 0.0057). NPAs were higher in nephropathy patients compared to normoalbuminuric patients (P = 0.0088). MPAs were higher in nephropathy patients compared to non-diabetic...

  16. The association of single nucleotide P-selectin gene polymorphism with IgA nephropathy

    Institute of Scientific and Technical Information of China (English)

    王朝晖

    2006-01-01

    Objective IgA nephropathy is one of the most com- mon form of primary glomerulonephritis throughout the world and a main renal disease which causes renal failure. P-selectin plays an important role in the pathogenesis and development of IgA nephropathy. The purpose of this study is to find a possible relationship between P-selectin gene polymorphism and IgA nephropathy. Methods In this study,a comprehensive P-selectin gene sur-

  17. Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey

    OpenAIRE

    Jae Hee Ahn; Ji Hee Yu; Seung-Hyun Ko; Hyuk-Sang Kwon; Dae Jung Kim; Jae Hyeon Kim; Chul Sik Kim; Kee-Ho Song; Jong Chul Won; Soo Lim; Sung Hee Choi; Kyungdo Han; Bong-Yun Cha; Nan Hee Kim

    2014-01-01

    Background Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and de...

  18. Efficacy and safety of mycophenolate mofetil treatment in IgA nephropathy: a systematic review

    OpenAIRE

    Chen, Youyuan; Li, Yumin; Yang, ShengLin; Li, Yan; Liang, Min

    2014-01-01

    Background IgA nephropathy is the most common primary glomerular disease worldwide and also the most frequent cause of kidney failure. Mycophenolate mofetil (MMF) is a selective immunosuppressant widely used in many autoimmune diseases. However, the benefits and risks of MMF for the treatment of IgA nephropathy remain uncertain. Methods A systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to assess the efficacy and safety of MMF in IgA nephropathy patient...

  19. The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

    OpenAIRE

    Jiang, Tao; Huang, Zheping; Lin, Yifeng; Zhang, Zhigang; Fang, Deyu; Zhang, Donna D.

    2010-01-01

    OBJECTIVE Diabetic nephropathy is one of the major causes of renal failure, which is accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that controls the antioxidant response essential for maintaining cellular redox homeostasis. Here, we report our findings demonstrating a protective role of Nrf2 against diabetic nephropathy. RESEARCH DESIGN AND METHODS We explore the protective role of Nrf2 against diabetic nephropathy using human kidney ...

  20. Concomitant macro and microvascular complications in diabetic nephropathy

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    Alwakeel Jamal

    2009-01-01

    Full Text Available To determine the prevalence of concomitant microvascular and macrovascular complica-tions of diabetic nephropathy we retrospectively reviewed the medical records of all 1,952 type 2 dia-betic patients followed-up at Security Forces Hospital, Riyadh, Saudi Arabia from January 1989 to December 2004. There were 626 (32.1% patients (294 (47% were males who developed diabetic nephropathy. Their mean age was 66.9 ± 11.4 years, mean duration of diabetes was 15.4 ± 7.5 years, mean age at the onset of nephropathy was 61.5 ± 12.4 years, and mean duration of nephropathy was 3.9 ± 3.8 years. Concomitant diabetic complications included cataract (38.2%, acute coronary syndrome (36.1%, peripheral neuropathy (24.9%, myocardial infarction (24.1%, background retinopathy (22.4%, stroke (17.6%, proliferative retinopathy (11.7%, foot infection (7.3%, limb amputation (3.7% and blindness (3%. Hypertension was documented in 577 (92.2% patients, dyslipidemia in 266 (42.5% and mortality from all causes in 86 (13.7%. There were 148 (23.6% patients with one complication, 81 (12.9% with two, 83 (13.3% with three, and 61 (9.7% with four or more. Dete-rioration of glomerular filtration rate was observed in 464 (74% patients and doubling of serum creatinine in 250 (39.9%, while 95 (15.2% developed end-stage renal disease (ESRD at the end of study and 79 (12.6% required dialysis. Complications were significantly more prevalent among males with greater number reaching ESRD level than females (P< 0.05. Relative risks of developing com-plications were significant after the onset of nephropathy; ACS (1.41, MI (1.49, stroke (1.48, diabetic foot (1.6, amputation (1.58 and death (1.93. We conclude that complications of diabetes are aggre-ssive and progressive including high prevalence of diabetic nephropathy. Careful monitoring and proper institution of management protocols should be implemented to identify diabetic patients at high risk for complications and mitigate progression

  1. The Balkan Sprachbund in the Republic of Macedonia Today: 'Eurology' as Discontinuity and Dialectology as Continuity

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    Victor Friedman

    2015-07-01

    In the article, I attempt to uphold the thesis about the continuity of the processes which gave rise to the phenomenon of the Balkan linguistic league. I argue that these processes are very much alive in today’s Republic of Macedonia and in other Balkan states. I develop my thesis drawing on examples from modern languages: Macedonian, Albanian, Aromanian, and Romani in its urban variation spoken in modern Republic of Macedonia. However, while in all other Balkan states the classic Balkan multilingualism is present as a distinctive feature on the local level, in Macedonia it is manifest both on the local level and in the cities. I thus point out the need for dialectological research in urban and multilingual rural sites so as to overcome the limitations of classic dialectology, with its historic-nationalist, monolingual focus. Only the former type of research allows for the study of language contact as the source of language change. Finally, I emphasise the fact that the Balkan Sprachbund assumed its present form in a period when what became the core of the EU was divided into dozens of mini-states, while in the Ottoman state, as Olivera Jašar-Nasteva said, you could travel the whole territory of the Empire with one document (teskere. This means that the idea of creating a unified linguistic alliance with the centre constituted by the “old” EU member states and the Balkans as its periphery is a product of contemporary political situation, not of the historical context which enabled the emergence of the Balkan Sprachbund. Bałkańska liga językowa w Republice Macedonii dziś: „eurologia” jako nieciągłość i dialektologia jako ciągłość W niniejszym artykule staram się podtrzymać tezę o ciągłości funkcjonowania procesów, które wykreowały fenomen bałkańskiej ligi językowej i ich żywotności na terytorium dzisiejszej Republiki Macedonii, a także na obszarze pozostałych bałkańskich państw. Tezę tę dokumentuję poprzez przyk

  2. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

    Science.gov (United States)

    Shahzad, Khurrum; Bock, Fabian; Dong, Wei; Wang, Hongjie; Kopf, Stefan; Kohli, Shrey; Al-Dabet, Moh'd Mohanad; Ranjan, Satish; Wolter, Juliane; Wacker, Christian; Biemann, Ronald; Stoyanov, Stoyan; Reymann, Klaus; Söderkvist, Peter; Groß, Olaf; Schwenger, Vedat; Pahernik, Sascha; Nawroth, Peter P; Gröne, Herman-Josef; Madhusudhan, Thati; Isermann, Berend

    2015-01-01

    Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic nephropathy with inflammasome activation has recently been shown, but the pathophysiological relevance of this finding remains unknown. Within glomeruli, inflammasome activation was detected in endothelial cells and podocytes in diabetic humans and mice and in glucose-stressed glomerular endothelial cells and podocytes in vitro. Abolishing Nlrp3 or caspase-1 expression in bone marrow-derived cells fails to protect mice against diabetic nephropathy. Conversely, Nlrp3-deficient mice are protected against diabetic nephropathy despite transplantation of wild-type bone marrow. Pharmacological IL-1R antagonism prevented or even reversed diabetic nephropathy in mice. Mitochondrial reactive oxygen species (ROS) activate the Nlrp3 inflammasome in glucose or advanced glycation end product stressed podocytes. Inhibition of mitochondrial ROS prevents glomerular inflammasome activation and nephropathy in diabetic mice. Thus, mitochondrial ROS and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy. Targeting the inflammasome may be a potential therapeutic approach to diabetic nephropathy.

  3. Trablusgarb ve Balkan Savaşları’nın Osmanlı Devleti’nin Ticaret-i Hariciyesi Üzerindeki Etkileri The Impacts Of Tripolitanian And Balkan Wars On The Ottoman Foreign Trade

    Directory of Open Access Journals (Sweden)

    Filiz ÇOLAK

    2013-07-01

    Full Text Available The last ten years of the Ottoman State witnessed successivewars. These ten years began with the Tripolitanian War, which was aTurkish-Italian war, and ended with the Balkan Wars, World War I andTurkish War of Independence. These wars led to deterioration ofpolitical and economic conditions of the state and eventually to its fall.The Tripoli and Balkan Wars deeply influenced foreign policy andtrade of the Ottoman State. The Tripolitanian War began in 1911 whenItaly invaded Tripolitania and caused tension in the Ottoman-Italianeconomic relations even for a while. The same boycott, previouslyimplemented by the Ottoman State against Austrian goods as a result ofBosnia and Herzegovina invasion of Austria-Hungary in 1908, wasimplemented against Italian goods in 1911. The idea of boycott initiallycame up in the press, because the government was late to declare waragainst Italy. However Babıâli could not prevent Italian goods enteringthe country due to capitulations, therefore resorted to increase thecustoms duties taken from Italian goods. This policy continued until thepeace treaty in 1912.In 1912 the Ottoman State found itself at war with the BalkanLeague, an alliance formed by the Balkan States (Bulgaria, Greece,Montenegro, Serbia led by Bulgaria. Babıâli entered this war withoutany preparation and during the war Babıâli on the one hand tried tomeet army’s needs and on the other hand tried to take precautions byreviewing its economic relations with these countries. As a first step,like in the Tripolitanian War, Babıâli increased the customs dutiesapplied during trade activities with these Balkan countries and laterboycott was implemented against them by the Ottoman State. Thispolicy continued until the peace treaties in 1913 and ended after thepeace.In this study we will try to answer how these wars affected theforeign trade of the Ottoman State. The impact of these wars on theimport and export relations between Italy/Balkan States and

  4. Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy.

    Science.gov (United States)

    Roncal-Jimenez, Carlos; García-Trabanino, Ramón; Barregard, Lars; Lanaspa, Miguel A; Wesseling, Catharina; Harra, Tamara; Aragón, Aurora; Grases, Felix; Jarquin, Emmanuel R; González, Marvin A; Weiss, Ilana; Glaser, Jason; Sánchez-Lozada, Laura G; Johnson, Richard J

    2016-01-01

    Mesoamerican nephropathy (MeN), an epidemic in Central America, is a chronic kidney disease of unknown cause. In this article, we argue that MeN may be a uric acid disorder. Individuals at risk for developing the disease are primarily male workers exposed to heat stress and physical exertion that predisposes to recurrent water and volume depletion, often accompanied by urinary concentration and acidification. Uric acid is generated during heat stress, in part consequent to nucleotide release from muscles. We hypothesize that working in the sugarcane fields may result in cyclic uricosuria in which uric acid concentrations exceed solubility, leading to the formation of dihydrate urate crystals and local injury. Consistent with this hypothesis, we present pilot data documenting the common presence of urate crystals in the urine of sugarcane workers from El Salvador. High end-of-workday urinary uric acid concentrations were common in a pilot study, particularly if urine pH was corrected to 7. Hyperuricemia may induce glomerular hypertension, whereas the increased urinary uric acid may directly injure renal tubules. Thus, MeN may result from exercise and heat stress associated with dehydration-induced hyperuricemia and uricosuria. Increased hydration with water and salt, urinary alkalinization, reduction in sugary beverage intake, and inhibitors of uric acid synthesis should be tested for disease prevention.

  5. Models of the potential distribution and habitat preferences of the genus Pipiza (Syrphidae: Diptera on the Balkan peninsula

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    Nikolić Tijana

    2013-01-01

    Full Text Available Seven species of the genus Pipiza, collected throughout the southern and western Balkans, were used for the analysis of habitat preferences and potential geographical distribution on the Balkan Peninsula. The analyzed species show a wide and uneven distribution across the delineated geographical-biogeographical regions. The highest number of species noted is from two regions - the Dinaric mountain chain and the Pannonian and subpannonian regions (seven and six. Land cover patch analysis revealed that forests dominate the landscape surroundings of the analyzed species. “Presenceonly models” developed by Maxent support the understanding of the distribution and ecology of each analyzed species. The low probability values of current potential distribution correspond to large non-forested and fragmented forest areas, where, on the other hand, relatively high probabilities overlap with areas of deciduous forests across the peninsula. Results confirm species preference to forest landscapes and emphasize the need for local scale analysis. The studies are of importance in developing regional monitoring schemes and conservation strategies.

  6. Genius Loci Balkani: Reception of the Past and the Construction of the Academic Narrative on the Balkan Heritage

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    Vladimir D. Mihajlović

    2016-02-01

    Full Text Available Postcolonial and postmodern perspectives, entering the humanities over the last decades of the 20th century, have contributed to the awareness that the present European interpretations of the past have been strongly influenced by the social and ideological context of the 19th and 20th centuries. Consciously or otherwise, the pioneers of research into the Classical antiquities have perceived the object of their research through their own perception of the relations in the world that surrounded them, thus inscribing their contemporaneous values onto the past and using thus conceived past in understanding, explaining and justifying the modern social/cultural phenomena. This contribution poses the question to which extent the social trends in the Kingdom of Yugoslavia have inspired and enabled the creation of an academic narrative about the uniqueness of the Balkan lands, based upon the continuity with the "ancient humanism", and social/cultural values, (allegedly defined at the times of Ancient Greece and Hellenism. The relationship is considered between the modern trends and the formation of academic issues in the case of social and political circumstances that coincided with the creation of the discourse of the "Balkan spirit". The narrative is considered from the times of its formation up to the present, as well as the reasons for its wide popularity both in the academic community and the general public.

  7. Diversity and endemism of Peruvian mammals

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    Víctor Pacheco

    2011-07-01

    Full Text Available We present an annotated list for all land, aquatic and marine mammals known to occur in Peru and their distribution by ecoregions. We also present species conservation status according to international organizations and the legal conservation status in Peru. At present, we record 508 species, in 13 orders, 50 families, and 218 genera, making Peru the third most diverse country with regards to mammals in the New World, after Brazil and Mexico, and the fifth most diverse country for mammals in the World. This diversity includes 40 didelphimorphs, 2 paucituberculates, 1 manatee, 6 cingulates, 7 pilosa, 39 primates, 162 rodents, 1 rabbit, 2 soricomorphs, 165 bats, 34 carnivores, 2 perissodactyls, and 47 cetartiodactyls. Bats and rodents (327 species represent almost two thirds of total diversity (64% for Peru. Five genera and 65 species (12.8% are endemics to Peru, with the majority of these being rodents (45 species, 69,2%. Most of the endemic species are restricted to the Yungas of the eastern slope of the Andes (39 species, 60% followed by Selva Baja (14 species, 21.5%. The taxonomic status of some species is commented on, when those depart from accepted taxonomy. The marsupial Marmosa phaea; the rodents Melanomys caliginosus, M. robustulus, and Echinoprocta rufescens; the shrew Cryptotis equatoris; the bats Anoura fistulata, Phyllostomus latifolius, Artibeus ravus, Cynomops greenhalli, Eumops maurus, and Rhogeessa velilla; and the carnivore Nasuella olivacea are first records of species occurrence in Peru. Finally, we also include a list of 15 non-native species.

  8. The Stochastic Modelling of Endemic Diseases

    Science.gov (United States)

    Susvitasari, Kurnia; Siswantining, Titin

    2017-01-01

    A study about epidemic has been conducted since a long time ago, but genuine progress was hardly forthcoming until the end of the 19th century (Bailey, 1975). Both deterministic and stochastic models were used to describe these. Then, from 1927 to 1939 Kermack and McKendrick introduced a generality of this model, including some variables to consider such as rate of infection and recovery. The purpose of this project is to investigate the behaviour of the models when we set the basic reproduction number, R0. This quantity is defined as the expected number of contacts made by a typical infective to susceptibles in the population. According to the epidemic threshold theory, when R0 ≤ 1, minor epidemic occurs with probability one in both approaches, but when R0 > 1, the deterministic and stochastic models have different interpretation. In the deterministic approach, major epidemic occurs with probability one when R0 > 1 and predicts that the disease will settle down to an endemic equilibrium. Stochastic models, on the other hand, identify that the minor epidemic can possibly occur. If it does, then the epidemic will die out quickly. Moreover, if we let the population size be large and the major epidemic occurs, then it will take off and then reach the endemic level and move randomly around the deterministic’s equilibrium.

  9. EPIDEMIOLOGY OF MALARIA IN ENDEMIC AREAS

    Directory of Open Access Journals (Sweden)

    Beatrice Autino

    2012-01-01

    Full Text Available

    Malaria infection is still to be considered a major public health problem in those 106 countries where the risk of contracting the infection with one or more of the Plasmodium species exists. According to estimates from the World Health Organization, over 200 million cases and about 655.000 deaths have occurred in 2010. Estimating the real health and social burden of the disease is a difficult task, because many of the malaria endemic countries have limited diagnostic resources, especially in rural settings where conditions with similar clinical picture may coexist in the same geographical areas. Moreover, asymptomatic parasitaemia may occur in high transmission areas after childhood, when anti-malaria semi-immunity occurs. Malaria endemicity and control activities are very complex issues, that are influenced by factors related to the host, to the parasite, to the vector, to the environment and to the health system capacity to fully implement available anti-malaria weapons such as rapid diagnostic tests, artemisinin-based combination treatment, impregnated bed-nets and insecticide residual spraying while waiting for an effective vaccine to be made available.

  10. EPIDEMIOLOGY OF MALARIA IN ENDEMIC AREAS

    Directory of Open Access Journals (Sweden)

    Beatrice Autino

    2012-10-01

    Full Text Available Malaria infection is still to be considered a major public health problem in those 106 countries where the risk of contracting the infection with one or more of the Plasmodium species exists. According to estimates from the World Health Organization, over 200 million cases and about 655.000 deaths have occurred in 2010. Estimating the real health and social burden of the disease is a difficult task, because many of the malaria endemic countries have limited diagnostic resources, especially in rural settings where conditions with similar clinical picture may coexist in the same geographical areas. Moreover, asymptomatic parasitaemia may occur in high transmission areas after childhood, when anti-malaria semi-immunity occurs. Malaria endemicity and control activities are very complex issues, that are influenced by factors related to the host, to the parasite, to the vector, to the environment and to the health system capacity to fully implement available anti-malaria weapons such as rapid diagnostic tests, artemisinin-based combination treatment, impregnated bed-nets and insecticide residual spraying while waiting for an effective vaccine to be made available.

  11. Endemic taxa of vascular plants in the Polish Carpathians

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    Halina Piękoś-Mirkowa

    2011-01-01

    Full Text Available The Carpathians, particularly their highest massif, the Tatra Mountains, exhibit the greatest richness of endemics in Poland. The present paper is a critical recapitulation of existing knowledge of endemism among the vascular plants of the Polish part of the Carpathians. It comprises a list of all 110 taxa (49 species, 26 microspecies of the genus Alchemilla and 35 conspicuous subspecies that can be considered Carpathian endemics or subendemics. Their distribution, vertical ranges and habitats are characterized.

  12. Endemism in the Cladocera (Crustacea: Branchiopoda) of Southern Africa

    OpenAIRE

    2013-01-01

    We review the current state of knowledge and patterns of distribution in the endemic Cladocera (Crustacea: Branchiopoda) of Southern Africa and describe two species of the Western Cape, of which one is new to science. Frey (1993), Korovchinsky (2006) and Smirnov (2008) previously suggested that South Africa harbours few endemics in the Cladocera. In the current study, we show that so-called low endemism in this region is mainly attributed to our limited state of knowledge of the local clado...

  13. [DIABETIC NEPHROPATHY AS A CAUSE OF CHRONIC KIDNEY DISEASE].

    Science.gov (United States)

    Kos, Ivan; Prkačin, Ingrid

    2014-12-01

    Diabetic nephropathy is the leading cause of end-stage chronic kidney disease in most developed countries. Hyperglycemia, hypertension and genetic predisposition are the main risk factors for the development of diabetic nephropathy. Elevated serum lipids, smoking habits, and the amount and origin of dietary protein also seem to play a role as risk factors. Clinical picture includes a progressive increase in albuminuria, decline in glomerular filtration, hypertension, and a high risk of cardiovascular morbidity and mortality. Screening for albuminuria should be performed yearly, starting 5 years after diagnosis in type 1 diabetes or earlier in the presence of adolescence or poor metabolic control. In patients with type 2 diabetes, screening should be performed at diagnosis and yearly thereafter. Patients with albuminuria should undergo evaluation regarding the presence of associated comorbidities, especially retinopathy and macrovascular disease. Achieving the best metabolic control (HbA1c diabetes.

  14. CLINICAL GUIDELINE FOR THE TREATMENT OF DIABETIC NEPHROPATHY

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    R. A. Nadeeva

    2015-01-01

    Full Text Available Due to the high prevalence of diabetes the annual increase of the number of patients with diabetic nephropathy is evidenced. The progressive course of this sequellae and a high percentage of end-stage kidney disease requires a clear approach of early diagnosis, the development of methods of prevention and early treatment from the perspective of evidence-based medicine. This review provides recommendations on glucose-lowering treatment, monitoring of blood pressure and proteinuria, hyperlipidemia. Defi ned individual targets of the correction of hyperglycaemia, depending on the level of albuminuria excretion and the severity of the patient. Indicated the possibilities of applications of certain antidiabetic drugs, depending on the level of glomerular fi ltration rate. Drugs of the fi rst and second line are marked for the selection of antihypertensive treatment. Showed the possible ways to reduce the level of albuminuria. Presented recommendations for the management of patients, depending on the stage of nephropathy.

  15. Chemical substances as risk factors of nephropathy in diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Zofia Marchewka

    2009-12-01

    Full Text Available Although diabetes mellitus, a metabolic disease, does not fall into the group of diseases induced by toxic substances or environmental pollution, there is much evidence that some chemicals have considerable importance in its development. Exposure to substances with potential renal toxicity is especially dangerous for diabetics because it accelerates and intensifies diabetic nephropathy. This paper discusses the relationship between the xenobiotics and the development of diabetes mellitus and diabetic nephropathy with particular emphasis on those substances that causes the greatest damage to the kidneys. These are cadmium, iron, lead, arsenic, polychlorinated organic compounds, nitrogen compounds, and contrast agents. In addition, the mechanisms of diabetes mellitus induction or kidney damage by these xenobiotics are described.

  16. Features of endothelial dysfunction in early diabetic nephropathy

    DEFF Research Database (Denmark)

    Jensen, T; Bjerre-Knudsen, J; Feldt-Rasmussen, B

    1989-01-01

    ); group II (n = 11), incipient diabetic nephropathy (30-300 mg albumin excreted per 24 h); and group III (n = 10), clinical diabetic nephropathy (more than 300 mg albumin excreted per 24 h). Nine non-diabetic men served as controls. The rise in tPA antigen with exercise was similar in the controls......The release of tissue plasminogen activator (tPA) by vascular endothelial cells during exercise was studied in forty men with insulin-dependent diabetes. Three groups, matched for age and diabetes duration, were defined as: group I (n = 19), normal urinary albumin excretion (less than 30 mg/24 h.......01) and II (difference not significant, p = 0.06) than in group I and normal controls. These findings suggest that insulin-dependent diabetic patients with only slightly raised urinary albumin excretion have general endothelial cell dysfunction or damage. It is not yet clear whether these changes...

  17. Hydroclimatological Controls of Endemic and Non-endemic Cholera of the 20th Century

    Science.gov (United States)

    Jutla, A. S.; Whitcombe, E.; Colwell, R.

    2012-12-01

    Cholera remains a major public health threat for the developing countries. Since the causative agent, Vibrio cholerae, is autochthonous to aquatic environment, it is not possible to eradicate the agent of the disease. Hydroclimatology based prediction and prevention strategies can be implemented in disease susceptible regions for reducing incidence rates. However, the precise role of hydrological and climatological processes, which will further aid in development of suitable prediction models, in creating spatial and temporal environmental conditions favorable for disease outbreak has not been adequately quantified. Here, we show distinction between seasonality and occurrence of cholera in epidemic and non-endemic regions. Using historical cholera mortality data, from the late 1800s for 27 locations in the Indian subcontinent, we show that non-endemic regions are generally located close to regional river systems but away from the coasts and are characterized by single sporadic outbreak in a given year. Increase in air temperature during the low river flow season increases evaporation, leading to an optimal salinity and pH required for bacterial growth. Thereafter, monsoonal rainfall, leads to interactions of contaminated river waters via human activity resulting in cholera epidemics. Endemic regions are located close to coasts where cholera outbreak occurs twice (spring and fall) in a year. Spring outbreak is generally associated with intrusion of bacterial seawater to inland whereas the fall peak is correlated with widespread flooding and cross-contamination of water resources via increased precipitation. This may be one of the first studies to hydroclimatologically quantitatively the seasonality of cholera in both endemic and non-endemic regions. Our results prompt the need of region and cause-specific prediction models for cholera, employing appropriate environmental determinants.

  18. Light-chain nephropathy in patient with renal carcinoma.

    OpenAIRE

    Enia, G.; Maringhini, S; L'Abbate, A; Zoccali, C.; Maggiore, Q

    1981-01-01

    Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cell carcinoma, and the patient underwent a radical nephrectomy. Two years after operation serum phosph...

  19. A Multivariate Analysis of Risk Factors for Diabetic Nephropathy

    Directory of Open Access Journals (Sweden)

    Anthony Shannon

    2007-03-01

    Full Text Available This paper uses multivariate methods on actual data from 267 patients with noninsulin- dependent (Type 2 diabetes mellitus in order to see how the various risk factors can affect the progression of diabetic nephropathy. The approach succeeds in identifying preliminary risk factors such as smoking for males, although the females had higher fasting blood glucose at diagnosis. Not surprisingly, hypertension is common among patients of both sexes and it has an association with proteinuria in female patients in the sample.

  20. Early pre-eclampsia unmasks underlying IgA nephropathy

    OpenAIRE

    Mona Singh; Akhenaton Pappoe; Don, Burl R.

    2010-01-01

    Mona Singh, Akhenaton Pappoe, Burl R DonDivision of Nephrology, University of California Davis Medical Center, Sacramento, CA, USAAbstract: Pre-eclampsia is the most ominous complication of pregnancy, and primary glomerular diseases can mimic pre-eclampsia in presentation. A patient presented at 21 weeks gestation with signs and symptoms of both pre-eclampsia and primary glomerular nephropathy. A critical clinical decision whether to continue or terminate the pregnancy was dependent on result...

  1. Paracetamol and analgesic nephropathy: Are you kidneying me?

    OpenAIRE

    Waddington F; Naunton M; Thomas J

    2014-01-01

    Freya Waddington, Mark Naunton, Jackson Thomas Faculty of Health, University of Canberra, Canberra, ACT, Australia Introduction: Analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years, leading to significant impairment of renal function. The observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initial recognition of the nephrotoxicity from the use of...

  2. Bilateral scleritis and sclerokeratitis associated with IgA nephropathy

    OpenAIRE

    Garza-Leon, Manuel; Flores, Diana; Alarcón-Galván, Gabriela; Sánchez-Martínez, Concepción

    2012-01-01

    Purpose The purpose of this study is to report a case of bilateral nodular scleritis in a patient with final diagnosis of IgA nephropathy. Methods This is an observational case report. Results A male patient, 42 years old, presented with a bilateral nodular scleritis and OD sclerokeratitis. He had a previous history of acute otitis media and developed posterior renal failure and arterial hypertension. Clinical and systemic findings suggest Wegener's granulomatosis. A kidney biopsy was perform...

  3. Idiopathic membranous nephropathy complicated with malignant hypertension: a case report

    Institute of Scientific and Technical Information of China (English)

    TAO Jian-ling; LI Hang; WEN Yu-bing; LI Xue-wang

    2007-01-01

    @@ Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. Its insidious onset and progression often hinder timely renal biopsy and early diagnosis delaying treatment while worsening prognosis. The complication of malignant hypertension(MHT) is rarely seen in idiopathic MN. To provide a better understanding of the disease we report a case of idiopathic MN diagnosed by biopsy six years after onset.

  4. Extract of Adenanthera pavonina L. seed reduces development of diabetic nephropathy in streptozotocin-induced diabetic rats

    Directory of Open Access Journals (Sweden)

    Ramdas Pandhare

    2012-09-01

    Conclusion: These results suggested that APSAE has reduced development of diabetic nephropathy in streptozotocin-induced diabetic rats and could have beneficial effect in reducing the progression of diabetic nephropathy.

  5. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Alejandra Guillermina Miranda-Díaz

    2016-01-01

    Full Text Available The increase in the prevalence of diabetes mellitus (DM and the secondary kidney damage produces diabetic nephropathy (DN. Early nephropathy is defined as the presence of microalbuminuria (30–300 mg/day, including normal glomerular filtration rate (GFR or a mildly decreased GFR (60–89 mL/min/1.73 m2, with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is 300 mg/day. Chronic kidney disease (CKD is characterized by abnormalities in renal function that persist for >3 months with health implications. Alterations in the redox state in DN are caused by the persistent state of hyperglycemia and the increase in advanced glycation end products (AGEs with ability to affect the renin-angiotensin system and the transforming growth factor-beta (TGF-β, producing chronic inflammation and glomerular and tubular hypertrophy and favoring the appearance of oxidative stress. In DN imbalance between prooxidant/antioxidant processes exists with an increase in reactive oxygen species (ROS. The overproduction of ROS diminishes expression of the antioxidant enzymes (manganese superoxide dismutase, glutathione peroxidase, and catalase. The early detection of CKD secondary to DN and the timely identification of patients would permit decreasing its impact on health.

  6. Urinary exosomal microRNAs in incipient diabetic nephropathy.

    Science.gov (United States)

    Barutta, Federica; Tricarico, Marinella; Corbelli, Alessandro; Annaratone, Laura; Pinach, Silvia; Grimaldi, Serena; Bruno, Graziella; Cimino, Daniela; Taverna, Daniela; Deregibus, Maria Chiara; Rastaldi, Maria Pia; Perin, Paolo Cavallo; Gruden, Gabriella

    2013-01-01

    MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Results showed that miR-130a and miR-145 were enriched, while miR-155 and miR-424 reduced in urinary exosomes from patients with microalbuminuria. Similarly, in an animal model of early experimental diabetic nephropathy, urinary exosomal miR-145 levels were increased and this was paralleled by miR-145 overexpression within the glomeruli. Exposure of cultured mesangial cells to high glucose increased miR-145 content in both mesangial cells and mesangial cells-derived exosomes, providing a potential mechanism for diabetes-induced miR-145 overexpression. In conclusion, urinary exosomal miRNA content is altered in type 1 diabetic patients with incipient diabetic nephropathy and miR-145 may represent a novel candidate biomarker/player in the complication.

  7. Urinary exosomal microRNAs in incipient diabetic nephropathy.

    Directory of Open Access Journals (Sweden)

    Federica Barutta

    Full Text Available MicroRNAs (miRNAs, a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephropathy. Results showed that miR-130a and miR-145 were enriched, while miR-155 and miR-424 reduced in urinary exosomes from patients with microalbuminuria. Similarly, in an animal model of early experimental diabetic nephropathy, urinary exosomal miR-145 levels were increased and this was paralleled by miR-145 overexpression within the glomeruli. Exposure of cultured mesangial cells to high glucose increased miR-145 content in both mesangial cells and mesangial cells-derived exosomes, providing a potential mechanism for diabetes-induced miR-145 overexpression. In conclusion, urinary exosomal miRNA content is altered in type 1 diabetic patients with incipient diabetic nephropathy and miR-145 may represent a novel candidate biomarker/player in the complication.

  8. Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy.

    Science.gov (United States)

    Polanco, Natalia; Gutiérrez, Elena; Covarsí, Adelardo; Ariza, Francisco; Carreño, Agustín; Vigil, Ana; Baltar, José; Fernández-Fresnedo, Gema; Martín, Carmen; Pons, Salvador; Lorenzo, Dolores; Bernis, Carmen; Arrizabalaga, Pilar; Fernández-Juárez, Gema; Barrio, Vicente; Sierra, Milagros; Castellanos, Ines; Espinosa, Mario; Rivera, Francisco; Oliet, Aniana; Fernández-Vega, Francisco; Praga, Manuel

    2010-04-01

    Spontaneous remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until remission of disease at 14.7 +/- 11.4 months. Although spontaneous remission was more frequent with lower levels of baseline proteinuria, it also frequently occurred in patients with massive proteinuria: 26% among those with baseline proteinuria 8 to 12 g/24 h and 22% among those with proteinuria >12 g/24 h. Baseline serum creatinine and proteinuria, treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, and a >50% decline of proteinuria from baseline during the first year of follow-up were significant independent predictors for spontaneous remission. Only six patients (5.7%) experienced a relapse of nephrotic syndrome. The incidence of death and ESRD were significantly lower among patients with spontaneous remission. In conclusion, spontaneous remission is common among patients with nephrotic syndrome resulting from membranous nephropathy and carries a favorable long-term outcome with a low incidence of relapse. A decrease in proteinuria >50% from baseline during the first year predicts spontaneous remission.

  9. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

    Science.gov (United States)

    Andrade-Sierra, Jorge

    2016-01-01

    The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30–300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60–89 mL/min/1.73 m2), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is 300 mg/day. Chronic kidney disease (CKD) is characterized by abnormalities in renal function that persist for >3 months with health implications. Alterations in the redox state in DN are caused by the persistent state of hyperglycemia and the increase in advanced glycation end products (AGEs) with ability to affect the renin-angiotensin system and the transforming growth factor-beta (TGF-β), producing chronic inflammation and glomerular and tubular hypertrophy and favoring the appearance of oxidative stress. In DN imbalance between prooxidant/antioxidant processes exists with an increase in reactive oxygen species (ROS). The overproduction of ROS diminishes expression of the antioxidant enzymes (manganese superoxide dismutase, glutathione peroxidase, and catalase). The early detection of CKD secondary to DN and the timely identification of patients would permit decreasing its impact on health. PMID:27525285

  10. A case of membranous nephropathy associated with chronic sinusitis.

    Science.gov (United States)

    Kanazawa, Ippei; Yano, Shozo; Takase, Hirofumi; Yamane, Yuko; Yamaguchi, Toru; Sugimoto, Toshitsugu

    2009-01-01

    Here we report a case of a 71-year-old Japanese woman with membranous nephropathy complicated with chronic sinusitis. The patient visited our hospital for treatment of edema and proteinuria, and was diagnosed as nephrotic syndrome with serum total protein 7.5 g/dL, albumin 2.2 g/dL and urine protein 3.7 g/day. Renal biopsy revealed membranous glomerulonephritis with tubulointerstitial nephritis. She had suffered from chronic sinusitis for several years. Laboratory tests showed that immunoglobulin G (IgG) and soluble interleukin-2 receptor (sIL-2R) were markedly increased (3,233 mg/dL and 5,110 U/mL, respectively) and Gallium scintigraphy showed abnormal accumulation to the paranasal sinus. After operation for chronic sinusitis, the levels of IgG and sIL-2R were decreased, and nephrotic syndrome was improved without any other specific treatments. It is known that various diseases, including membranous nephropathy and sinusitis, are caused by T-cell dysfunction. Thus, we suspect the pathogenetic link between membranous nephropathy and chronic sinusitis in this case, most probably through T-cell dysfunction.

  11. Ichthyosiform mycosis fungoides with alopecia and atypical membranous nephropathy

    Directory of Open Access Journals (Sweden)

    Qiang Zhou

    2011-01-01

    Full Text Available We describe here a rare case of variant of mycosis fungoides (MF: ichthyosiform MF with alopecia and atypical membranous nephropathy. The diagnosis was made based on the following findings: generalized ichthyosis-like eruption, alopecia, enlarged superficial lymph nodes, proteinuria, and hematuria, the histological features of the skin biopsy from both ichthyotic and alopecic lesions with immunohistochemical staining, and the renal biopsy examination with immunofluorescence. The histological examination of ichthyotic and alopecic lesions displayed a predominant infiltration of atypical lymphocytes in the upper dermis with the characteristics of epidermotropism and folliculotropism. Immunohistochemical studies demonstrated that most infiltrated atypical lymphocytes were CD3, CD4, and CD45RO positive, whereas negative for CD5, CD7, CD20, CD30, and CD56. A renal biopsy examination revealed atypical membranous nephropathy with deposition of immunoglobulin G (IgG, IgM, IgA, C1q, and C3. In this case atypical membranous nephropathy was involved, which is very uncommon and has never been presented in the literature to date. Although ichthyosiform MF usually features a relatively favorable course, diffuse alopecia and the renal involvement in this case might indicate aggressive disease and poor prognosis.

  12. C1q Nephropathy: The Unique Underrecognized Pathological Entity

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    Joe Devasahayam

    2015-01-01

    Full Text Available C1q nephropathy is a rare glomerular disease with characteristic mesangial C1q deposition noted on immunofluorescence microscopy. It is histologically defined and poorly understood. Light microscopic features are heterogeneous and comprise minimal change disease (MCD, focal segmental glomerulosclerosis (FSGS, and proliferative glomerulonephritis. Clinical presentation is also diverse, and ranges from asymptomatic hematuria or proteinuria to frank nephritic or nephrotic syndrome in both children and adults. Hypertension and renal insufficiency at the time of diagnosis are common findings. Optimal treatment is not clear and is usually guided by the underlying light microscopic lesion. Corticosteroids are the mainstay of treatment, with immunosuppressive agents reserved for steroid resistant cases. The presence of nephrotic syndrome and FSGS appear to predict adverse outcomes as opposed to favorable outcomes in those with MCD. Further research is needed to establish C1q nephropathy as a universally recognized distinct clinical entity. In this paper, we discuss the current understanding of pathogenesis, histopathology, clinical features, therapeutic options, and outcomes of C1q nephropathy.

  13. Interstitial capillary changes in lithium nephropathy: effects of antihypertensive treatment.

    Science.gov (United States)

    Skyum, Helle; Marcussen, Niels; Nielsen, Steen Horne; Christensen, Sten

    2004-10-01

    Histopathological changes were investigated in the tubulointerstitium and in the capillaries of male Wistar rats with lithium-induced nephropathy using stereological methods. Two antihypertensive drugs with opposite effects on the renin-angiotensin system, an ACE inhibitor (angiotensin converting enzyme inhibitor) and a thiazide diuretic, modified the nephropathy. Generally, there was a significant positive correlation between the reduction in GFR (glomerular filtration rate) and the reduction in the volume of intact tubular structures and interstitial capillaries. A significant negative correlation was seen between the reduction in GFR and the increase in tubulocapillary distance and the absolute volume of interstitial connective tissue, respectively. Treatment with perindopril, and to some extent hydrochlorothiazide, reversed the rise in systolic blood pressure associated with lithium-induced nephropathy but did not affect the progression to terminal uraemia, the structural renal changes or the mortality. In conclusion, severe tubular and capillary changes are seen in this model of chronic renal failure. Tubular atrophy is associated with a decrease in interstitial capillaries and with an increase in the tubulocapillary distance. Systemic hypertension or activation of the renin-angiotensin system may not be important factors for the progression to terminal renal failure.

  14. Spontaneous Remission of Nephrotic Syndrome in Idiopathic Membranous Nephropathy

    Science.gov (United States)

    Polanco, Natalia; Gutiérrez, Elena; Covarsí, Adelardo; Ariza, Francisco; Carreño, Agustín; Vigil, Ana; Baltar, José; Fernández-Fresnedo, Gema; Martín, Carmen; Pons, Salvador; Lorenzo, Dolores; Bernis, Carmen; Arrizabalaga, Pilar; Fernández-Juárez, Gema; Barrio, Vicente; Sierra, Milagros; Castellanos, Ines; Espinosa, Mario; Rivera, Francisco; Oliet, Aniana; Fernández-Vega, Francisco

    2010-01-01

    Spontaneous remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until remission of disease at 14.7 ± 11.4 months. Although spontaneous remission was more frequent with lower levels of baseline proteinuria, it also frequently occurred in patients with massive proteinuria: 26% among those with baseline proteinuria 8 to 12 g/24 h and 22% among those with proteinuria >12 g/24 h. Baseline serum creatinine and proteinuria, treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, and a >50% decline of proteinuria from baseline during the first year of follow-up were significant independent predictors for spontaneous remission. Only six patients (5.7%) experienced a relapse of nephrotic syndrome. The incidence of death and ESRD were significantly lower among patients with spontaneous remission. In conclusion, spontaneous remission is common among patients with nephrotic syndrome resulting from membranous nephropathy and carries a favorable long-term outcome with a low incidence of relapse. A decrease in proteinuria >50% from baseline during the first year predicts spontaneous remission. PMID:20110379

  15. Tephrostratigraphic studies on a sediment core from Lake Prespa in the Balkans

    Directory of Open Access Journals (Sweden)

    M. Damaschke

    2013-01-01

    Full Text Available A detailed tephrostratigraphic record, which dates back to Marine Isotope Stage (MIS 5b (ca. 91 kyr, has been established from a 17.76 m long core (Co1215 from Lake Prespa (Macedonia, Albania and Greece. A total of eleven tephra and cryptotephra layers (PT0915-1 to PT0915-11 were identified, using XRF scanning, magnetic susceptibility measurements, and macro- and microscopic inspection of the sediments. The major element composition of glass shards and/or micro-pumice fragments indicates that the tephras and cryptotephras originate from the explosive volcanism of Italy. Eight tephra and cryptotephra layers were correlated with specific volcanic eruptions: the AD 512 eruption of Somma-Vesuvius (1438 cal yr BP, the Mercato eruption of Somma-Vesuvius (8890 ± 90 cal yr BP, the Tufi Biancastri/LN1-LN2 eruption of the Campi Flegrei (14 749 ± 523 cal yr BP and 15 551 ± 621 cal yr BP, the SMP1-e/Y-3 eruption of the Campi Flegrei (30 000–31 000 cal yr BP, the Campanian Ignimbrite/Y-5 eruption of the Campi Flegrei (39 280 ± 110 cal yr BP, the SMP1-a event of Ischia Island (around 44 000 cal yr BP and the Green Tuff/Y-6 eruption of Pantelleria Island (around 45 000 cal yr BP. One tephra could be attributed to the volcanic activity of Mount Etna, but probably represents an unknown eruption at ca. 60 000 cal yr BP. Cryptotephras PT0915-6 and PT0915-10 remain unclassified so far, but according to the presented age-depth model these would have been deposited around 35 000 and 48 500 cal yr BP, respectively. Some of the tephras and cryptotephras are recognised for the first time in the Balkan region. The tephrostratigraphic work provides important information about ash dispersal and explosion patterns of source volcanoes and can be used to correlate and date geographically distant paleoenvironmental and archaeological archives in the central Mediterranean region. Moreover, the tephrostratigraphic work in combination with radiocarbon and electron spin

  16. Tephrostratigraphic studies on a sediment core from Lake Prespa in the Balkans

    Directory of Open Access Journals (Sweden)

    M. Damaschke

    2012-09-01

    Full Text Available A detailed tephrostratigraphic record, which dates back to Marine Isotope Stage (MIS 5, has been established from a 17.76 m long core (Co1215 from Lake Prespa (Macedonia, Albania and Greece. A total of eleven tephra and cryptotephra layers (PT0915-1 to PT0915-11 were identified, using XRF scanning, magnetic susceptibility measurements, and macro- and microscopic inspection of the sediments. The major element composition of glass shards and/or micro-pumice fragments indicates that the tephras and cryptotephras originate from the explosive volcanism of Italy. Eight tephra and cryptotephra layers were correlated with specific volcanic eruptions: cryptotephra PT0915-1 with the 512 AD eruption of Somma-Vesuvius (1438 cal yr BP, tephra PT0915-2 with the Mercato eruption of Somma-Vesuvius (8890 ± 90 cal yr BP, cryptotephras PT0915-3 and PT0915-4 with Tufi Biancastri/LN1-LN2 of the Campi Flegrei (14 749 ± 523 cal yr BP and 15 551 ± 621 cal yr BP, tephra PT0915-5 with the SMP1-e/Y-3 eruption of the Campi Flegrei (30 000–31 000 cal yr BP, tephra PT0915-7 with the Campanian Ignimbrite/Y-5 of the Campi Flegrei (39 280 ± 110 cal yr BP, cryptotephra PT0915-8 with the SMP1-a event of Ischia Island (around 44 000 cal yr BP and tephra PT0915-9 with the Green Tuff/Y-6 eruption of Pantelleria Island (around 45 000 cal yr BP. Tephra PT0915-11 could be attributed to the volcanic activity of Mount Etna, but probably represents a hitherto unknown eruption at ca. 60 000 cal yr BP. Cryptotephras PT0915-6 and PT0915-10 remain unclassified so far, but according to the presented age-depth model these would have been deposited around 35 000 and 48 500 cal yr BP, respectively. Some of the tephras and cryptotephras are recognised for the first time in the Balkan region. The tephrostratigraphic work provides important information about ash dispersal and explosion patterns of source volcanoes and can be used to correlate and date geographically distant paleoenvironmental

  17. Tephrostratigraphic studies on a sediment core from Lake Prespa in the Balkans

    Science.gov (United States)

    Damaschke, M.; Sulpizio, R.; Zanchetta, G.; Wagner, B.; Böhm, A.; Nowaczyk, N.; Rethemeyer, J.; Hilgers, A.

    2013-01-01

    A detailed tephrostratigraphic record, which dates back to Marine Isotope Stage (MIS) 5b (ca. 91 kyr), has been established from a 17.76 m long core (Co1215) from Lake Prespa (Macedonia, Albania and Greece). A total of eleven tephra and cryptotephra layers (PT0915-1 to PT0915-11) were identified, using XRF scanning, magnetic susceptibility measurements, and macro- and microscopic inspection of the sediments. The major element composition of glass shards and/or micro-pumice fragments indicates that the tephras and cryptotephras originate from the explosive volcanism of Italy. Eight tephra and cryptotephra layers were correlated with specific volcanic eruptions: the AD 512 eruption of Somma-Vesuvius (1438 cal yr BP), the Mercato eruption of Somma-Vesuvius (8890 ± 90 cal yr BP), the Tufi Biancastri/LN1-LN2 eruption of the Campi Flegrei (14 749 ± 523 cal yr BP and 15 551 ± 621 cal yr BP), the SMP1-e/Y-3 eruption of the Campi Flegrei (30 000-31 000 cal yr BP), the Campanian Ignimbrite/Y-5 eruption of the Campi Flegrei (39 280 ± 110 cal yr BP), the SMP1-a event of Ischia Island (around 44 000 cal yr BP) and the Green Tuff/Y-6 eruption of Pantelleria Island (around 45 000 cal yr BP). One tephra could be attributed to the volcanic activity of Mount Etna, but probably represents an unknown eruption at ca. 60 000 cal yr BP. Cryptotephras PT0915-6 and PT0915-10 remain unclassified so far, but according to the presented age-depth model these would have been deposited around 35 000 and 48 500 cal yr BP, respectively. Some of the tephras and cryptotephras are recognised for the first time in the Balkan region. The tephrostratigraphic work provides important information about ash dispersal and explosion patterns of source volcanoes and can be used to correlate and date geographically distant paleoenvironmental and archaeological archives in the central Mediterranean region. Moreover, the tephrostratigraphic work in combination with radiocarbon and electron spin resonance (ESR

  18. A proton nuclear magnetic resonance-based metabonomics study of metabolic profiling in immunoglobulin a nephropathy

    Directory of Open Access Journals (Sweden)

    Weiguo Sui

    2012-01-01

    Full Text Available OBJECTIVES: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients. The ability to diagnose immunoglobulin A nephropathy remains poor. However, renal biopsy is an inconvenient, invasive, and painful examination, and no reliable biomarkers have been developed for use in routine patient evaluations. The aims of the present study were to identify immunoglobulin A nephropathy patients, to identify useful biomarkers of immunoglobulin A nephropathy and to establish a human immunoglobulin A nephropathy metabolic profile. METHODS: Serum samples were collected from immunoglobulin A nephropathy patients who were not using immunosuppressants. A pilot study was undertaken to determine disease-specific metabolite biomarker profiles in three groups: healthy controls (N = 23, low-risk patients in whom immunoglobulin A nephropathy was confirmed as grades I-II by renal biopsy (N = 23, and high-risk patients with nephropathies of grades IV-V (N = 12. Serum samples were analyzed using proton nuclear magnetic resonance spectroscopy and by applying multivariate pattern recognition analysis for disease classification. RESULTS: Compared with the healthy controls, both the low-risk and high-risk patients had higher levels of phenylalanine, myo-Inositol, lactate, L6 lipids ( = CH-CH2-CH = O, L5 lipids (-CH2-C = O, and L3 lipids (-CH2-CH2-C = O as well as lower levels of β -glucose, α-glucose, valine, tyrosine, phosphocholine, lysine, isoleucine, glycerolphosphocholine, glycine, glutamine, glutamate, alanine, acetate, 3-hydroxybutyrate, and 1-methylhistidine. CONCLUSIONS: These metabolites investigated in this study may serve as potential biomarkers of immunoglobulin A nephropathy. Point scoring of pattern recognition analysis was able to distinguish immunoglobulin A nephropathy patients from healthy controls. However, there were no obvious differences between the low-risk and high-risk groups in our

  19. A proton nuclear magnetic resonance-based metabonomics study of metabolic profiling in immunoglobulin a nephropathy

    Energy Technology Data Exchange (ETDEWEB)

    Sui, Weiguo; Che, Wenti; Guimai, Zuo; Chen, Jiejing [181st Hospital Guangxi, Central Laboratory, Laboratory of Metabolic Diseases Research, Guangxi Province (China); Li, Liping [Guangxi Normal University, The Life Science College, Guangxi Province (China); Li, Wuxian [Key Laboratory of Laboratory Medical Diagnostics of Education Ministry, Chongqiong Medical University, Chongqing (China); Dai, Yong [Clinical Medical Research Center, the Second Clinical Medical College of Jinan University (Shenzhen People' s Hospital), Shenzhen, Guangdong Province (China)

    2012-07-01

    Objectives: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients. The ability to diagnose immunoglobulin A nephropathy remains poor. However, renal biopsy is an inconvenient, invasive, and painful examination, and no reliable biomarkers have been developed for use in routine patient evaluations. The aims of the present study were to identify immunoglobulin A nephropathy patients, to identify useful biomarkers of immunoglobulin A nephropathy and to establish a human immunoglobulin A nephropathy metabolic profile. Methods: Serum samples were collected from immunoglobulin A nephropathy patients who were not using immunosuppressants. A pilot study was undertaken to determine disease-specific metabolite biomarker profiles in three groups: healthy controls (N = 23), low-risk patients in whom immunoglobulin A nephropathy was confirmed as grades I-II by renal biopsy (N = 23), and high-risk patients with nephropathies of grades IV-V (N = 12). Serum samples were analyzed using proton nuclear magnetic resonance spectroscopy and by applying multivariate pattern recognition analysis for disease classification. Results: Compared with the healthy controls, both the low-risk and high-risk patients had higher levels of phenylalanine, myo-inositol, lactate, L6 lipids ( CH-CH{sub 2}-CH = O), L5 lipids (-CH{sub 2}-C = O), and L3 lipids (-CH{sub 2}-CH{sub 2}-C = O) as well as lower levels of {beta}-glucose, {alpha}-glucose, valine, tyrosine, phosphocholine, lysine, isoleucine, glycerolphosphocholine, glycine, glutamine, glutamate, alanine, acetate, 3-hydroxybutyrate, and 1-methylhistidine. Conclusions: These metabolites investigated in this study may serve as potential biomarkers of immunoglobulin A nephropathy. Point scoring of pattern recognition analysis was able to distinguish immunoglobulin A nephropathy patients from healthy controls. However, there were no obvious differences between the low-risk and high

  20. Origin and differentiation of endemism in the flora of China

    Institute of Scientific and Technical Information of China (English)

    WU Zhengyi; SUN Hang; ZHOU Zhekun; PENG Hua; LI Dezhu

    2007-01-01

    The present paper analyzed 239 endemic genera in 67 families in the flora of seed plants in China.The results showed that there are five families containing more than ten endemic genera,namely,Gesneriaceae (27),which hereafter refers to the number of endemic genera in China,Composite (20),Labiatae (12),Cruciferae (11),and Umbelliferae (10),15 families with two endemic genera,and another 30 families with only one endemic genus.Four monotypic families (Ginkgoaceae,Davidiaceae,Eucommiaceae and Acanthochlamydaceae)are the most ancient,relict and characteristic in the flora of seed plants in China.Based on integrative data of systematics,fossil history,and morphological and molecular evidence of these genera,their origin,evolution and relationships were discussed.In gymnosperms,all endemic genera are relicts of the Arctic-Tertiary flora,having earlier evolutionary history,and can be traced back to the Cretaceous or to the Jurassic and even earlier.In angiosperms,the endemic genera are mostly relicts,and are represented in all lineages in the"Eight-Class System ofClassification of Angiosperms",and endemism can be found in almost every evolutionary stage of extant angiosperms.The relict genera once occupied huge areas in the northern hemisphere in the Tertiary or the late Cretaceous,while neo-endemism mostly originated in the late Tertiary.They came from Arctic-Tertiary,Paleo-tropical-Tertiary and Tethys-Tertiary florisitic elements,and the blend of the three elements with many genera of autochthonous origin.The endemism was formed when some dispersal routes such as the North Atlantic Land Bridge,and the Bering Bridge became discontinuous during the Tertiary,as well as the climate change and glaciations in the late Tertiary and the Quaternary.Therefore,the late Tertiary is the starting point of extant endemism of the flora in China.

  1. Risks and Opportunities of Urbanization – Structure of Two Populations of the Balkan Wall Lizard Podarcis tauricus (Pallas, 1814 in the City of Plovdiv

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    Ivelin A. Mollov

    2009-08-01

    Full Text Available The current study analyzes the structure and some features of two urban metapopulations of the Balkan Wall Lizard (Podarcis tauricus (Pallas, 1814 from Nature Monument (NM “Mladezhki halm” and Nature Monument “Halm na osvoboditelite” in the city of Plovdiv (South Bulgaria. In both study sites, the Balkan Wall lizard inhabits exclusively the interior of the hills and prefers mainly open areas with rare grass and shrub vegetation. The recorded dominant plant species are not autochthonous for the hills, but gradually displaced with many decorative species, used widely in the gardening and thecity parks. The population abundance from both hills is relatively low, with higher values in NM “Mladezhki halm” and generally shows a decrease pattern for the two year period. In the hills of Plovdiv, the Balkan Wall lizard shows a bimodal diurnal and seasonal activity. Both metapopulations showed a sex ratio close to 1:1 with a slight superiority of the females (1:1.29, but with no statistically significant deviation. The age structure of both metapopulations is almost identical - the highest percentage takes the adults, followed by the subadults and juveniles, with no significant deviations from the normal ratio. The possible reasons for the contemporary distribution and population structure of the Balkan Wall lizard are discussed. Historic land use change and its effect on the populations are discussed as well. The main risks for this species in the city of Plovdiv are construction and forestation (destruction of open terrains. Nevertheless, the Balkan Wall lizard seems to have successfully overcome the risks of urbanization and its population seem stable and sustainable.

  2. Iodinated contrast agent-induced nephropathy; Mit jodhaltigen Kontrastmitteln induzierte Nephropathie

    Energy Technology Data Exchange (ETDEWEB)

    Erley, C. [St. Joseph-Krankenhaus Berlin, Berlin (Germany)

    2007-09-15

    Contrast-induced nephropathy (CIN) is a well-known complication of therapeutic and diagnostic procedures requiring contrast administration and accounts for 10% of acute renal failure in hospitalized patients. Although the incidence of this complication is relatively low, its consequences can be catastrophic. The development of CIN is associated with increased length of hospital stay, an increased requirement for acute dialysis, and an increased risk of death. Preexisting renal dysfunction, age, diabetes, congestive heart failure, and volume of administered contrast are all associated with a risk of developing CIN. Despite a large number of clinical trials that have evaluated prophylaxis strategies for CIN, no uniform strategies have been developed so far. The use of N-acetyl-L-cysteine (NAC) or theophylline in specific subgroups of patients has been shown to reduce dialysis requirement and mortality in patients undergoing angiographic procedures. Hemofiltration has also shown positive results. In this review we will discuss the epidemiology and the risk factors for CIN and the evidence for commonly employed prophylaxis strategies, and we will provide general recommendations with respect to CIN prevention and management. A practicable strategy to prevent CIN includes: correct identification of individuals at greatest risk, thorough evaluation of whether other diagnostic maneuvers could be employed instead (i.e., sonography), application of low-osmolar contrast media at the minimum acceptable dose, stopping potential nephrotoxic drugs (NSAID), hydration with sodium chloride 0.9% 1 ml/kg per h i.v. 12 h before and after CM application, administration of acetylcysteine 600 mg twice the day before and after (in cases of emergency investigation and high-risk patients 1200 mg i.v.), and theophylline (250-350 mg) the day before and the day after CM application (in cases of emergency investigation 5 mg/kg i.v.). (orig.) [German] Die Kontrastmittelnephropathie (contrast

  3. Cytotoxic compounds from endemic Arnebia purpurea.

    Science.gov (United States)

    Yuzbasioglu, Merve; Kuruuzum-Uz, Ayse; Guvenalp, Zuhal; Simon, András; Tóth, Gabór; Harput, U Sebnem; Kazaz, Cavit; Bilgili, Bilgehan; Duman, Hayri; Saracoglu, Iclal; Demirezer, L Omur

    2015-04-01

    Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

  4. Endemic human fasciolosis in the Bolivian Altiplano.

    Science.gov (United States)

    Parkinson, M; O'Neill, S M; Dalton, J P

    2007-05-01

    Fasciolosis, caused by trematodes of the genus Fasciola, is an emerging disease of humans. One of the highest levels of human fasciolosis hepatica is found amongst the indigenous Aymaran people of the Northern Bolivian Altiplano. A meta-analysis of epidemiological surveys from 38 communities in the region demonstrates that fasciolosis has been endemic in the region since at least 1984 and is a zoonosis of rural communities. Human and bovine fasciolosis is associated with the communities lying in the plain from Lake Titicaca to La Paz, predominantly in the Los Andes province. In Los Andes incidences of up to 67% of population cohorts were found, and prevalence is age-related with the highest infection rate in children aged 8-11 years.

  5. Incidence of renal replacement therapy for diabetic nephropathy in the Netherlands: Dutch diabetes estimates (DUDE)-3

    NARCIS (Netherlands)

    Dijk, P.R. van; Kramer, A.; Logtenberg, S.J.; Hoitsma, A.J.; Kleefstra, N.; Jager, K.J.; Bilo, H.J.G.

    2015-01-01

    OBJECTIVES: Describe the incidence, prevalence and survival of patients needing renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetes mellitus (DM)-related glomerulosclerosis or nephropathy (diabetic nephropathy, DN) in the Netherlands. DESIGN: Using the national registr

  6. Incidence of renal replacement therapy for diabetic nephropathy in the Netherlands : Dutch diabetes estimates (DUDE)-3

    NARCIS (Netherlands)

    van Dijk, Peter R.; Kramer, Anneke; Logtenberg, Susan J. J.; Hoitsma, Andries J.; Kleefstra, Nanne; Jager, Kitty J.; Bilo, Henk J. G.

    2015-01-01

    Objectives: Describe the incidence, prevalence and survival of patients needing renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetes mellitus (DM)-related glomerulosclerosis or nephropathy (diabetic nephropathy, DN) in the Netherlands. Design: Using the national registr

  7. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

    Directory of Open Access Journals (Sweden)

    Hanyu Zhu

    2017-01-01

    Full Text Available Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. Presently, we interrogated glycopatterns in urine specimens using a lectin microarray. The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa in urine may contribute to this alteration. Furthermore, the glycopatterns of (GlcNAc2–4 recognized by STL exhibited difference between diabetic and nondiabetic nephropathy. The results of urinary protein microarray fabricated by another 48 urine specimens also indicated (GlcNAc2–4 is a potential indictor to differentiate the patients with diabetic nephropathy from nondiabetic nephropathy. Furtherly, STL blotting showed that the 50 kDa glycoproteins were correlated with this alteration. In conclusion, our data provide pivotal information to monitor the development of diabetic nephropathy and distinguish between diabetic nephropathy and nondiabetic renal disease based on precise alterations of glycopatterns in urinary proteins, but further studies are needed in this regard.

  8. Analgesic Nephropathy and Renal Replacement Therapy in Australia: Trends, Comorbidities and Outcomes

    OpenAIRE

    Chang, Sean Haw; Mathew, Timothy Hamish; McDonald, Stephen Peter

    2008-01-01

    Background and objectives: This study examined age-specific incidence and prevalence of renal replacement therapy attributed to analgesic nephropathy from 1971 through 2005 and adjusted comorbidity prevalence and survival of patients who had analgesic nephropathy and were on renal replacement therapy (compared with control subjects without diabetes).

  9. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy

    NARCIS (Netherlands)

    Stanescu, H.C.; Arcos-Burgos, M.; Medlar, A.; Bockenhauer, D.; Kottgen, A.; Dragomirescu, L.; Voinescu, C.; Patel, N.; Pearce, K.; Hubank, M.; Stephens, H.A.; Laundy, V.; Padmanabhan, S.; Zawadzka, A.; Hofstra, J.M.; Coenen, M.J.H.; Heijer, M. den; Kiemeney, L.A.L.M.; Bacq-Daian, D.; Stengel, B.; Powis, S.H.; Brenchley, P.; Feehally, J.; Rees, A.J.; Debiec, H.; Wetzels, J.F.M.; Ronco, P.; Mathieson, P.W.; Kleta, R.

    2011-01-01

    BACKGROUND: Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white population. METHODS: We performed independent

  10. Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy

    DEFF Research Database (Denmark)

    Astrup, Anne Sofie; Tarnow, Lise; Rossing, Peter

    2006-01-01

    Cardiac autonomic neuropathy (CAN) has been associated with a poor prognosis in patients with diabetes. Because CAN is common in patients with diabetic nephropathy, we evaluated the predictive value of CAN in type 1 diabetic patients with and without diabetic nephropathy....

  11. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats

    NARCIS (Netherlands)

    Waanders, Femke; van den Berg, Else; Nagai, Ryoji; van Veen, Ingrid; Navis, Gerjan; van Goor, Harry

    2008-01-01

    Background. Advanced glycation end products (AGEs) are involved in diabetic nephropathy (DN). The AGE formation inhibitor pyridoxamine (PM) is renoprotective in DN and in normoglycaemic obese Zucker rats. In chronic allograft nephropathy (CAN), renal AGE accumulation occurs as well. Methods. To inve

  12. Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice.

    Science.gov (United States)

    Bowen, Samantha E; Watt, Christine L; Murawski, Inga J; Gupta, Indra R; Abraham, Soman N

    2013-07-01

    Vesicoureteric reflux (VUR) is a common congenital defect of the urinary tract that is usually discovered after a child develops a urinary tract infection. It is associated with reflux nephropathy, a renal lesion characterized by the presence of chronic tubulointersitial inflammation and fibrosis. Most patients are diagnosed with reflux nephropathy after one or more febrile urinary tract infections, suggesting a potential role for infection in its development. We have recently shown that the C3H mouse has a 100% incidence of VUR. Here, we evaluate the roles of VUR and uropathogenic Escherichia coli infection in the development of reflux nephropathy in the C3H mouse. We find that VUR in combination with sustained kidney infection is crucial to the development of reflux nephropathy, whereas sterile reflux alone fails to induce reflux nephropathy. A single bout of kidney infection without reflux fails to induce reflux nephropathy. The host immune response to infection was examined in two refluxing C3H substrains, HeN and HeJ. HeJ mice, which have a defect in innate immunity and bacterial clearance, demonstrate more significant renal inflammation and reflux nephropathy compared with HeN mice. These studies demonstrate the crucial synergy between VUR, sustained kidney infection and the host immune response in the development of reflux nephropathy in a mouse model of VUR.

  13. Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy)

    OpenAIRE

    K, Prajna; Kumar J., Ashok; Rai, Srinidhi; Shetty, Shobith Kumar; Rai, Tirthal; Shrinidhi,; Begum, Mohamedi; MD, Shashikala

    2013-01-01

    Introduction: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated haemoglobin, serum creatinine and urine microalbumin: in type-2 diabetics without any complications; in type-2 diabetics with nephropathy; and in age and sex matched healthy individual (controls).

  14. Evidence for endemic chikungunya virus infections in Bandung, Indonesia

    NARCIS (Netherlands)

    Kosasih, H.; Mast, Q. de; Widjaja, S.; Sudjana, P.; Antonjaya, U.; Ma'roef, C.; Riswari, S.F.; Porter, K.R.; Burgess, T.H.; Alisjahbana, B.; Ven, A. van der; Williams, M.

    2013-01-01

    Chikungunya virus (CHIKV) is known to cause sporadic or explosive outbreaks. However, little is known about the endemic transmission of CHIKV. To ascertain the endemic occurrence of CHIKV transmission, we tested blood samples from patients with a non-dengue febrile illness who participated in a pros

  15. [Endemic goiter in Nepal. Comparisons with endemic goiter in the Piedmont].

    Science.gov (United States)

    Mortara, M; Cenderelli, G; Reposi, G; Migiardi, M; Costa, A

    1976-11-10

    Comparison of certain features of endemic goitre in the Khumbu district of Nepal and Piedmont is reported. Cases in the younger generations were observed in both areas. In Khumbu, the incidence of goitre in schoolchildren was 75% and cases were even noted in children who had been receiving iodine prophylactic management (injections of iodised oil: 500-1000 mg/yr) for at least three years. The iodine content of drinking water and the most commonly eaten foods was determined. Values were very low and a daily intake of not more than 30 mug was calculated. The findings are in line with metabolic studies carried out by other workers in Upper Khumbu. While it is clear that ambiental iodine deficiency is much higher in Khumbu than in those areas of Piedmont where goitre is most markedly endemic, the inadequacy of preventive iodine administration measures, and environmental features common to both areas, suggest that iodine deficiency is a concomitant factor and not the prime cause of endemic goitre.

  16. Modeling Extinction Risk of Endemic Birds of Mainland China

    Directory of Open Access Journals (Sweden)

    Youhua Chen

    2013-01-01

    Full Text Available The extinction risk of endemic birds of mainland China was modeled over evolutionary time. Results showed that extinction risk of endemic birds in mainland China always tended to be similar within subclades over the evolutionary time of species divergence, and the overall evolution of extinction risk of species presented a conservatism pattern, as evidenced by the disparity-through-time plot. A constant-rate evolutionary model was the best one to quantify the evolution of extinction risk of endemic birds of mainland China. Thus, there was no rate shifting pattern for the evolution of extinction risk of Chinese endemic birds over time. In a summary, extinction risk of endemic birds of mainland China is systematically quantified under the evolutionary framework in the present work.

  17. G protein-coupled receptors: potential therapeutic targets for diabetic nephropathy.

    Science.gov (United States)

    Ding, Hai-Hua; Ni, Wei-Jian; Tang, Li-Qin; Wei, Wei

    2015-12-16

    Diabetic nephropathy, a lethal microvascular complication of diabetes mellitus, is characterized by progressive albuminuria, excessive deposition of extracellular matrix, thickened glomerular basement membrane, podocyte abnormalities, and podocyte loss. The G protein-coupled receptors (GPCRs) have attracted considerable attention in diabetic nephropathy, but the specific effects have not been elucidated yet. Likewise, abnormal signaling pathways are closely interrelated to the pathologic process of diabetic nephropathy, despite the fact that the mechanisms have not been explored clearly. Therefore, GPCRs and its mediated signaling pathways are essential for priority research, so that preventative strategies and potential targets might be developed for diabetic nephropathy. This article will give us comprehensive overview of predominant GPCR types, roles, and correlative signaling pathways in diabetic nephropathy.

  18. Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians

    DEFF Research Database (Denmark)

    Cheema, Balneek Singh; Iyengar, Sreenivasa; Ahluwalia, Tarun Veer Singh

    2012-01-01

    of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed with the aim to examine the association of an OPN gene promoter polymorphism with diabetic nephropathy in Asian Indians. OPN C-443T (rs11730582) polymorphism was determined in 1115 type 2 diabetic...... patients belonging to two independently ascertained cohorts using Real time PCR based Taqman assay. We observed a nearly threefold elevated risk of diabetic nephropathy among carriers of T allele and TT genotype of OPN C-443T polymorphism. Further, this allele was found to be significantly associated...... with proteinuria and lower eGFR, a hallmark of diabetic nephropathy, in both our cohorts. This is the first study which suggests that OPN C-443T polymorphism may be a significant risk factor for diabetic nephropathy in type 2 diabetic patients....

  19. Determinants of Intravascular Resistance in Indian Diabetic Nephropathy Patients: A Hospital-Based Study

    Directory of Open Access Journals (Sweden)

    Anubhav Thukral

    2011-01-01

    Full Text Available Aims and Objectives. Metabolic dysregulation has failed to explain clinical variability of patients with diabetic nephropathy and hence a renewed interest emerged in haemodynamic factors as determinant of progression and development of diabetic nephropathy. We therefore studied for various factors which can correlate with raised renal vascular resistance in diabetic nephropathy. Material and Methods. Renal vascular resistance was measured in patients with established and incipient diabetic nephropathy and compared with controls using noninvasive color Doppler examinations of intrarenal vasculature. Results. Renal vascular resistance correlated with age, duration of disease, GFR, serum creatinine, and stage of retinopathy. Renal vascular resistance was significantly reduced in patients on treatment with RAAS inhibitors and insulin, than those on OHA and antihypertensives other than RAAS inhibitors. Conclusion. The study implies that renal vascular resistance may help identify diabetics at high risk of developing nephropathy, and these set of patients could be candidates for RAAS inhibition and early insulin therapy even in patients without albuminuria.

  20. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms.

    Science.gov (United States)

    Ni, Wei-Jian; Ding, Hai-Hua; Tang, Li-Qin

    2015-08-05

    Diabetic nephropathy is a progressive kidney disorder and is pathologically characterized by thickened glomerular and tubular basement membranes, accumulation of the extracellular matrix and increased mesangial hypertrophy. Growing evidence has suggested that diabetic nephropathy is induced by multiple factors, such as dyslipidemia, hyperglycemia, hemodynamic abnormalities and oxidative stress, based on genetic susceptibility. Berberine (BBR; [C20H18NO4](+)), an isoquinoline alkaloid, is the major active constituent of Rhizoma coptidis and Cortex phellodendri. Recent studies have demonstrated that berberine has various pharmacological activities, including lowering blood glucose, regulating blood lipids and reducing inflammation in addition to its antioxidant activity. These findings suggest that berberine has potential applications as a therapeutic drug for diabetic nephropathy, and has significant research value. However, the possible mechanisms have not been fully established. The purpose of this paper is to investigate the renoprotective mechanisms of berberine in diabetic nephropathy and highlight the importance of berberine as a potential therapeutic reagent for diabetic nephropathy treatment.

  1. Diabetic nephropathy: new approaches for improving glycemic control and reducing risk.

    Science.gov (United States)

    Schernthaner, Guntram; Schernthaner, Gerit Holger

    2013-01-01

    Nephropathy is a common consequence of diabetes, with a high prevalence in patients with type 1 (15%-25%) and type 2 diabetes mellitus (T2DM; 30%-40%). Nephropathy is associated with a poor prognosis and high economic burden. The risk of developing nephropathy increases with the duration of diabetes, and early diagnosis and treatment of risk factors for nephropathy (e.g., tight control of glycemia and hypertension) can reduce the development and progression of diabetic nephropathy. Advances in our understanding of the mechanisms of renal complications associated with diabetes and the etiology of nephropathy have identified additional risk factors for nephropathy, and novel therapeutic options are being explored. This review discusses the pathophysiology of diabetic nephropathy and common risk factors. Furthermore, we discuss emerging treatments for T2DM that could potentially slow or prevent the progression of diabetic nephropathy. The use of incretin-based therapies, such as the dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) analogs, is growing in patients with T2DM, due to their efficacy and tolerability profiles. As renal safety is a key factor when choosing treatment options to manage patients with T2DM, drugs that are suitable for use in patients with varying degrees of renal impairment without a requirement for dose adjustment, such as the DPP-4 inhibitor linagliptin, are of particular use. The ongoing advances in T2DM therapy may allow optimization of glycemic control in a wide range of patients, thereby helping to reduce the increasing morbidity and mortality associated with diabetic nephropathy.

  2. Can migrants from high-endemic countries cause new HIV outbreaks among heterosexuals in low-endemic countries?

    NARCIS (Netherlands)

    M. Xiridou; M. van der Veen; R. Coutinho; M. Prins

    2010-01-01

    Objectives: To investigate how the sexual behaviour of migrants originating from HIV-endemic countries affects the spread of HIV among heterosexuals in low-endemic countries. Methods: A mathematical model is developed describing the transmission of HIV in heterosexual partnerships between African mi

  3. Analysis of the effects of application of PST and SC on the performance of the UCPTE system in the Balkans

    Energy Technology Data Exchange (ETDEWEB)

    Papazoglou, T.M. [Technological Educational Inst., Iraklio (Greece); Popovic, D.P.; Mijailovic, S. [Nikola Tesla Inst., Belgrade (Yugoslavia)

    1995-11-01

    Comparison is made of the effectiveness on the steady state load flow control of the Phase Shifter and the Series Compensation. Attention is focused on the ability to reduce unscheduled loop flows and redirect power flows in the system. The Balkan section of UCPTE system resulting after the parallel synchronous interconnection of Bulgaria is used as test system with loading conditions corresponding to the 1995 peak load. The superior properties of PST on power flow control are shown. The positive effects of PST in maintaining a high level of steady state security while realizing relatively large multilateral power exchange programs are demonstrated. A comparison of the power flow control efficiencies and an economic estimate are made for PST and SC. 10 refs, 1 fig, 4 tabs

  4. Intangible Capital, Innovation and Export-Led Growth: Empirical Comparative Study of Slovenia and the Western Balkans

    Directory of Open Access Journals (Sweden)

    Marija Drenkovska

    2015-03-01

    Full Text Available In the face of progressing globalisation and liberalisation of the markets, innovation is the minimum necessary requirement for companies and countries to be globally competitive, and knowledge is the key input. In a comparative study we investigate the intellectual capital of a sample of firms from the Western Balkans and Slovenia, and analyse the link between intellectual capital, innovation, and export volume. Using unique survey data sets for these countries, we propose a structural model to examine our hypotheses. The results suggest that possessing intellectual capital does not suffice for firms’ global competitiveness and that higher presence on global markets may offer exposure to more advanced knowledge that firms cannot obtain in their domestic markets.

  5. Sattleria revisited: unexpected cryptic diversity on the Balkan Peninsula and in the south-eastern Alps (Lepidoptera: Gelechiidae).

    Science.gov (United States)

    Huemer, Peter; Timossi, Giovanni

    2014-03-21

    The taxonomy of Sattleria Povolný from the high mountain systems on the Balkan Peninsula and the adjacent parts of the Alps (south-eastern Alps, Dinaric Alps, Rila Mountains) is revised based on recently collected material and re-examined museum vouchers. Adult morphology and molecular data of the COI barcode region support the existence of six strictly allopatric species in this area, including four new species: Sattleria sophiae Timossi, sp. nov. (Parco Paneveggio-Pale di San Martino, Dolomites, Prov. Trento, Italy), Sattleria dolomitica Huemer, sp. nov. (Eastern Dolomites, Prov. South Tyrol, Italy), Sattleria dinarica Huemer, sp. nov. (Durmitor NP, Dinaric Alps, Montenegro) and Sattleria haemusi Huemer, sp. nov. (Rila Mts., Bulgaria; Šar Planina, Macedonia). 

  6. Chemotaxonomic Approach to the Central Balkan Sedum Species Based on Distribution of Triterpenoids in Their Epicuticular Waxes.

    Science.gov (United States)

    Jovanović, Snežana Č; Zlatković, Bojan K; Stojanović, Gordana S

    2016-04-01

    Triterpenoid distribution in epicuticular waxes of 20 central Balkan Sedum L. species and four out-groups of genera: Hylotelephium H. Ohba, Crassula L., Echeveria DC., and Kalanchoe Adans. were investigated for chemotaxonomic purposes. Identification and quantification of wax triterpenoids were performed by GC/MS and GC-FID analyses. Distribution of identified triterpenoids (oleanane, lupane, and taraxerane series), as a pattern in statistical analysis, indicated very good agreement with phylogeny and systematics, except members of series Rupestria Berger, in which case the distribution of triterpenoids did not support known classification in a satisfactory manner. According to the obtained clustering, Kalanchoe is shown as similar to Sedum samples, while the other out-groups were clearly separated.

  7. Climate change in the Carpathian-Balkan Area. Advancing research and cooperation

    Directory of Open Access Journals (Sweden)

    Marcel MINDRESCU

    2013-06-01

    researchers and scholars can find common grounds for discussion and collaboration (Hutchinson and Mindrescu, 2012.In this regard an international meeting was organized at the Geography Department, University of Suceava, Romania, and was cosponsored by the University of Suceava, the Applied Geography Association (GEOCONCEPT, Past Global Changes (PAGES and the Mountain Research Initiative (MRI. The purpose of the workshop was to bring together an international group of scientists interested in the Carpathian-Balkan region to discuss research results and promote opportunities for interdisciplinary and international collaboration. The entire workshop was webcast. The program centered on 36 oral and 15 poster presentations as well as open discussions on the climatic and environmental dynamics during the Pleistocene and Holocene. The 70 participants were from Romania, Hungary, Germany, United Kingdom, Bulgaria, Slovenia, Ukraine, Poland, Switzerland, Czech Republic, Greece and Belgium. For many young researchers and students the workshop offered an educational opportunity to present their results to an international audience and discuss their research in a multidisciplinary community.To promote follow-up activities in the region, the “Suceava working group” was created under the lead of Marcel Mindrescu, Angelica Feurdean, Eniko Magyari and Daniel Veres. A group website is currently being set up (http://atlas.usv.ro/www/climatechange/ and grant proposals will be prepared. The group will also coordinate the organization of a second regional workshop in 2014 in Romania. Further activities, such as summer camps or meetings in the field are also considered.

  8. SHORT STORIES IN THE BALKANS AND CONTEMPORARYSHORT STORIES IN THE WORLD

    Directory of Open Access Journals (Sweden)

    Larisa Softic - Gasal

    2014-01-01

    Full Text Available A comparative analysis of selected short stories in the Balkan countries, as well as contemporary short stories of the world, will show us that the key themes of those stories are very similar to the short stories written during the period of transition in Bosnia and Herzegovina (1995-2010. For example, the story of the Soul Operation by an Iranian writer Mohsen Mahmalbafa, The Falcons by a Dutch writer Kader Abdolaha and On the Kitchen Stairs by a Polish writer Witold Gombrowic zinter connect with short stories by authors from Bosnia and Herzegovina, such as The Secret of Raspberry jam by Karim Zaimović or The Devilish work of Zoran Riđanović. A common thread manifests itself in the aforementioned stories, more specifically, a common theme which focuses on the need for eradication of the seeds of submission and compliance with the political system. Most authors focus on their domestic political systems; however, some portray and analyze systems in other countries as they see it, such as a Dutch narrator who focuses on a potential threat of infringement of human freedom. Moreover, Bellow Hubei by an Argentinian writer Anhelika Gorodis her underlines the importance of humanization within a political order. Faruk Šehić examines the political system in Bosnia and Herzegovina from a slightly different perspective. His collection of stories Under Pressure emphases the issue of pressure in the above war model of short stories in Bosnia and Herzegovina. These stories are the product of pressure and anxiety, with intent to latently promote new ways of spiritual survival, directly relating to the concept and the theme of the story The Past Age Man by Christian Karlson Stead. Further analysis of the alienation theme singled out short stories in Bosnia and Herzegovina, Plants are Something Else by Alma Lazarevska and Dialogues by Lamija Begagić, and pointed out their connection with some recent international short stories such as The Last Defence by

  9. A simultaneous liver-kidney transplant recipient with IgA nephropathy limited to native kidneys and BK virus nephropathy limited to the transplant kidney.

    Science.gov (United States)

    Ujire, Manasa P; Curry, Michael P; Stillman, Isaac E; Hanto, Douglas W; Mandelbrot, Didier A

    2013-08-01

    Immunoglobulin A (IgA) deposition in the native kidneys of patients with liver disease is well described. Secondary IgA nephropathy usually is thought to be benign, but hematuria, proteinuria, and loss of kidney function have been reported in this context. BK virus nephropathy is an important cause of kidney transplant loss; however, BK virus nephropathy is rare in the native kidneys of patients who underwent transplantation of other organs. We report the case of a patient with alcohol-related end-stage liver disease and chronic kidney disease with hematuria who underwent simultaneous liver-kidney transplantation. His kidney function decreased over the course of several weeks posttransplantation. Biopsy of the transplant kidney showed BK virus nephropathy, but no IgA deposits. In contrast, biopsy of the native kidneys showed IgA deposits, but no BK virus nephropathy. To our knowledge, this is the first reported case of a simultaneous liver-kidney transplantation wherein both the native and transplant kidneys were biopsied posttransplantation and showed exclusively different pathologies. These findings confirm the predilection of BK virus nephropathy for transplant rather than native kidneys.

  10. Cultural cross-border co-operation among Balkan's countries with the case of Serbia and Bulgaria

    Directory of Open Access Journals (Sweden)

    Stojkov Borislav

    2008-01-01

    Full Text Available Cultural cross-border cooperation includes all fields of cross-border cooperation and gives base for main connections and interactions. Without strengthening cultural cross-border cooperation, it is impossible to build significant relations between neighbors. Culture, as a foundation, an activator and a purpose of development in cross-border regions, represents a cardinal and conditional factor of cross-border cooperation. Today's situation in the Balkans reveals ethnic diversity of this region and territorial dispersion of ethnic groups. This implies at the same time great cultural diversity as well as dispersal of various national cultures over the Balkan's states. During the 20th century Serbia and Bulgaria have very complex political and intrastate relations. But in the last 10 years there have been significant improvements in the cross-border cooperation between Serbia and Bulgaria. The results of these improvements are established Euro-regions and implemented cross-border projects between these two countries. Existing Euro-regions between Serbia and Bulgaria created links between various local authorities and made excellent basis for cross-border initiatives and joint projects to promote common interests across the border and cooperation for the common good of the border areas populations. The well managed cultural cross-border cooperation between these two countries will provide a clear view of common features and raise common identity for the region, contribute to tolerance and understanding between people in this area and enable them to overcome the peripheral status of the border region in their countries and improve the living conditions of the population.

  11. The role of the migrational zones in the historical processes in Central-Europe and in the Balkans

    Directory of Open Access Journals (Sweden)

    Gábor Csüllog

    2015-06-01

    Full Text Available La región de Europa Central y los Balcanes es una de las zonas de flujo más im-portantes de Europa, donde la migración de los pueblos ha estado ocurriendo durante miles de años, las influencias económicas y culturales se han extendido y la política del poder ha tenido vigencia. Sus características históricas y geográ-ficas determinantes son las siguientes: espacio geográfico común; flujos espaciales que unen los espacios; espacios estatales separados por acontecimientos políticos; espacios étnicos tipo mosaico creados por la migración; subdivisión de los espacios de amortiguamiento provoca-dos por los intereses de la política del poder.Palabras clave: Europa Central, Balcanes, Impe-rio Habsburgo, Imperio Otomano, zonas de migración._______________ The Central European region and the Balkans are one of the most important flow zones in Europe where the migration of peoples has been going on for thousands of years, eco-nomic and cultural influences have been spreading and power politics has taken effect. Its determinative historical and geographical features are as follows: common geographical space; spatial flows linking the spaces; state spaces separated by political events; mosaic-like ethnic spaces created by migration; dividing buffer spaces brought about by the interests of power politics.Keywords: Central Europe, Balkans, Habsburg Empire, Ottoman Empire, migrational zones.

  12. Balkan Ülkeleri Arasında Bilimsel ve Kültürel Bilgilerin Korunması ve Yönetiminde İşbirliği

    OpenAIRE

    Tonta, Yaşar

    2008-01-01

    In this paper the regional and international cooperative programmes carried out to preserve and manage the scientific and cultural information sources in the Balkan countries are reviewed. As successful digitization, protection and management of information sources is closely related with the availability of the networking facilities, the Internet infrastructures of the Balkan countries needed to support the “digital science” and “digital culture” are studied to identify applications an...

  13. Common drugs for stabilization of renal function in the progression of diabetic nephropathy and their relations with hypertension therapy.

    Science.gov (United States)

    Wang, Yuxuan; Wang, Chengcheng; Zhang, Xiuli; Gu, Harvest F; Wu, Liang

    2017-02-14

    Diabetic nephropathy is characterized by hypertension, progressive albuminuria, glomerulosclerosis and declines in glomerular filtration rate leading to end stage renal disease. Although the pathogenesis of diabetic nephropathy is not fully understood, current treatment of the patients with diabetic nephropathy is mainly based upon the control of hyperglycaemia and management of blood pressures. Several drugs, which are originally developed for hypertension therapy, have been adopted for stabilization of renal function in diabetic nephropathy. In this review, we first discuss the relationships between diabetic nephropathy and hypertension particularly in the renin-angiotensin-aldosterone system. We then summarize chemical structures, pharmacological characteristics and clinical studies of the common drugs used for treatment of diabetic nephropathy, while these drugs have effects against hypertension. This review may provide the constructive information for further drug development in diabetic nephropathy.

  14. Unraveling the Mystery of an Environmental Disease

    Energy Technology Data Exchange (ETDEWEB)

    Grollman, Arthur (Stony Brook University, Dept of Pharmacology)

    2008-05-15

    A progressive, invariably fatal kidney disease, Balkan endemic nephropathy, and the upper urothelial tract cancer associated with it, occur among residents of farming villages in the Danube river basin. Dr. Arthur Grollman and his colleagues began epidemiologic and clinical studies that resulted in the discovery that home-baked bread, a dietary staple of farm families living in the endemic area, was contaminated with aristolochic acid, a powerful kidney toxin and human carcinogen that was present in Aristolochia weeds that grow in local wheatfields.

  15. Role of the hexosamine biosynthetic pathway in diabetic nephropathy.

    Science.gov (United States)

    Schleicher, E D; Weigert, C

    2000-09-01

    The hexosamine biosynthetic pathway has been hypothesized to be involved in the development of insulin resistance and diabetic vascular complications. In particular, it was demonstrated that hyperglycemia-induced production of transforming growth factor-beta (TGF-beta1), a prosclerotic cytokine causally involved in the development of diabetic nephropathy. Several lines of evidence indicate that TGF-beta1 induction is mediated by the hexosamine pathway. In cultured mesangial cells, high glucose levels induce TGF-beta1 production. This effect is eliminated by inhibition of glutamine: fructose-6-phosphate-amidotransferase (GFAT), the rate-limiting enzyme of this pathway. Furthermore, stable overexpression of GFAT increased levels of TGF-beta1 protein, mRNA, and promoter activity. Inasmuch as stimulation or inhibition of GFAT increased or decreased high glucose-stimulated activity of protein kinase C (PKC), respectively, the observed effects appear to be transduced by PKC. In similar experiments, involvement of the hexosamine pathway in hyperglycemia-induced production of cytokines (TGF-alpha and basic fibroblast growth factor [bFGF]) was demonstrated in vascular smooth muscle cells. These studies also revealed a rapid increase in GFAT activity by treatment with agents that elevated levels of cyclic adenosine 3',5' monophosphate (cAMP), thus indicating that GFAT activity is tightly regulated by cAMP-dependent phosphorylation. Using immunohistochemistry and in situ hybridization, high expression of GFAT was found in human adipocytes, skeletal muscle, vascular smooth muscle cells, and renal tubular epithelial cells. whereas glomerular cells remained essentially unstained. However, significant staining occurred in glomerular cells of patients with diabetic nephropathy. Current data indicate that the flux through the hexosamine pathway, regulated by GFAT, may be causally involved in the development of diabetic vascular disease, particularly diabetic nephropathy.

  16. Value of routine dengue diagnosis in endemic countries

    Science.gov (United States)

    Ayukekbong, James Ayukepi; Oyero, Olufunmilayo G; Nnukwu, Samuel Ekpesu; Mesumbe, Henry Nzike; Fobisong, Cajetang Nkong

    2017-01-01

    Dengue is one of the most common arthropod-borne viral diseases in humans and it is a leading cause of illness and death in the tropical and subtropical regions of the world. It is thought to account for 400 million cases annually among approximately 3.97 billion people at risk of infection in 128 endemic countries. Despite the global prevalence of the disease, the availability of a vaccine is limited in most countries in the endemic areas. Most endemic countries in South America, South East Asia and Africa serve as attractive touristic sites for people from non-endemic countries who become infected and export the virus to dengue-free regions. Dengue fever typically resembles malaria and in endemic countries most cases of dengue are treated as presumptive malaria. Consequently, routine dengue diagnosis among persons with fever will offer early treatment and reduce the burden of the disease. Also, routine testing among travellers from endemic countries will reduce importation and prevent the geographical expansion of dengue. In this essay, we seek to highlight the usefulness of routine dengue testing in endemic countries. PMID:28239567

  17. Uric acid as a mediator of diabetic nephropathy

    DEFF Research Database (Denmark)

    Jalal, Diana I; Maahs, David M; Hovind, Peter

    2011-01-01

    Despite advances in the management of patients with diabetes, diabetic nephropathy (DN) remains the most common cause of end-stage renal disease in the United States and worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and the progression of DN. Recent...... that implicate uric acid in DN. Based on the evidence we review, we conclude the need for properly planned randomized controlled studies to decrease uric acid levels and assess the impact of such therapy on diabetic kidney disease....

  18. [Reflux nephropathy in absence of obvious vesicoureteral reflux].

    Science.gov (United States)

    Vino, L; Pedrolli, A; Portuese, A; Dal Cerè, M; Pizzini, C; Sinaguglia, G; Fanos, V

    2000-01-01

    Although the majority of patients with vesicoureteric reflux presents DMSA scan alterations, parenchimal renal scars are found also in children without vesicoureteric reflux. Two clinical cases of reflux nephropathy without evidence of reflux are presented. Several explanations could be advocated to justify this picture, including haematogenous source of infection, inadequate timing and/or procedure of cystouretrography, intermittency of reflux, ascending bacteria, previous presence of reflux, and appearance of controlateral reflux during the natural history of a monolateral documented reflux. Tailored diagnostic and therapeutic strategy should discussed for each patient.

  19. Minimal change disease versus IgA nephropathy.

    Science.gov (United States)

    Jabur, Wael Latif

    2009-01-01

    IgA nephropathy is the most common type of the glomerulonephritis all over the world. However, its clinical presentation is variable, as is the underlying histopathological lesion. We report herein a case of an adult with steroid responsive minimal change disease and IgA mesangial deposits. During the first two weeks of therapy with prednisolone, the patient reported dramatic improvement in his clinical condition and remitted his disease. Unfortunately, at the end of the second month of prednisolone therapy, an acute flare of viral hepatitis was diagnosed. Interes-tingly, the acute viral flare was without a concomitant relapse of proteinuria.

  20. Minimal change disease versus IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Jabur Wael

    2009-01-01

    Full Text Available IgA nephropathy is the most common type of the glomerulonephritis all over the world. However, its clinical presentation is variable, as is the underlying histopathological lesion. We report herein a case of an adult with steroid responsive minimal change disease and IgA mesangial deposits. During the first two weeks of therapy with prednisolone, the patient reported dramatic improvement in his clinical condition and remitted his disease. Unfortunately, at the end of the second month of prednisolone therapy, an acute flare of viral hepatitis was diagnosed. Interes-tingly, the acute viral flare was without a concomitant relapse of proteinuria.

  1. Lupus vulgaris with tubercular lymphadenitis and IgA nephropathy.

    Science.gov (United States)

    Khaira, Ambar; Rathi, Om P; Mahajan, Sandeep; Sharma, Alok; Dinda, Amit K; Tiwari, Suresh C

    2008-02-01

    A 14-year-old girl presented with a 10-year history of a large crusted plaque over the right thigh for 10 years and small reddish plaque over the left upper back for 3 months. On routine evaluation, she was found to have hematuria. Skin biopsy from the lesion was suggestive of skin tuberculosis (lupus vulgaris), and kidney biopsy showed features of IgA nephropathy (IgAN). Fine-needle aspiration from the inguinal lymph node was consistent with granulomatous disease. The patient has been on anti-tubercular treatment, and the hematuria has subsided.

  2. Emerging therapeutics for the treatment of diabetic nephropathy.

    Science.gov (United States)

    Brenneman, Jehrod; Hill, Jon; Pullen, Steve

    2016-09-15

    Diabetic nephropathy (DN) is the most common pathology contributing to the development of chronic kidney disease (CKD). DN caused by hypertension and unmitigated inflammation in diabetics, renders the kidneys unable to perform normally, and leads to renal fibrosis and organ failure. The increasing global prevalence of DN has been directly attributed to rising incidences of Type II diabetes, and is now the largest non-communicable cause of death worldwide. Despite the high morbidity, successful new treatments for DN are lacking. This review seeks to provide new insight on emerging clinical candidates under investigation for the treatment of DN.

  3. Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy.

    Science.gov (United States)

    Stehlé, Thomas; Audard, Vincent; Ronco, Pierre; Debiec, Hanna

    2015-06-01

    Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.

  4. Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population.

    Science.gov (United States)

    Ma, D H; Xu, Q Y; Liu, Y; Zhai, Q Q; Guo, M H

    2016-05-09

    In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction fragment length polymorphism. The results were then statistically analyzed using SPSS 17.0. The results of the χ(2) test revealed a significant difference in the frequencies of the GG, GA, and AA genotypes of IL-10 -1082G/A between patients with diabetic nephropathy and control subjects (χ(2) = 10.03, P = 0.007). Unconditional logistic regression analysis revealed that the AA genotype of IL-10 -1082G/A significantly increased the susceptibility to diabetic nephropathy [adjusted odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.31-4.82] compared to the wild-type genotype. Moreover, the A allele of this polymorphism was associated with an increased risk of diabetic nephropathy compared to the G allele (adjusted OR = 1.51, 95%CI = 1.15-1.99). However, the IL-10 -819T/C and -592A/C genetic polymorphisms did not increase the risk of diabetic nephropathy. In conclusion, the IL-10 -1082G/A polymorphism was found to be correlated with the development of diabetic nephropathy.

  5. Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice.

    Science.gov (United States)

    Klein, Julie; Ramirez-Torres, Adela; Ericsson, Anette; Huang, Yufeng; Breuil, Benjamin; Siwy, Justyna; Mischak, Harald; Peng, Xiao-Rong; Bascands, Jean-Loup; Schanstra, Joost P

    2016-11-01

    Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting diabetic nephropathy failed. This lack of translational value may in part be due to an inadequate comparability of human disease and animal models that often capture only a few aspects of disease. Here we overcome this limitation by developing a multimolecular noninvasive humanized readout of diabetic nephropathy based on urinary peptidomics. The disease-modified urinary peptides of 2 type 2 diabetic nephropathy mouse models were identified and compared with previously validated urinary peptide markers of diabetic nephropathy in humans to generate a classifier composed of 21 ortholog peptides. This classifier predicted the response to disease and treatment with inhibitors of the renin-angiotensin system in mice. The humanized classifier was significantly correlated with glomerular lesions. Using a human type 2 diabetic validation cohort of 207 patients, the classifier also distinguished between patients with and without diabetic nephropathy, and their response to renin-angiotensin system inhibition. Thus, a combination of multiple molecular features common to both human and murine disease could provide a significant change in translational drug discovery research in type 2 diabetic nephropathy.

  6. Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

    Directory of Open Access Journals (Sweden)

    Gina Manda

    2015-01-01

    Full Text Available This review emphasizes the role of oxidative stress in diabetic nephropathy, acting as trigger, modulator, and linker within the complex network of pathologic events. It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative, and inflammatory stresses. Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation, and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators. Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. Finally, the antioxidant response of renal cells in diabetic nephropathy is tackled, with emphasis on targeted therapy. An integrative approach is needed for identifying key molecular networks which control cellular responses triggered by the array of stressors in diabetic nephropathy. This will foster the discovery of reliable biomarkers for early diagnosis and prognosis, and will guide the discovery of new therapeutic approaches for personalized medicine in diabetic nephropathy.

  7. Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes.

    Science.gov (United States)

    Manda, Gina; Checherita, Alexandru-Ionel; Comanescu, Maria Victoria; Hinescu, Mihail Eugen

    2015-01-01

    This review emphasizes the role of oxidative stress in diabetic nephropathy, acting as trigger, modulator, and linker within the complex network of pathologic events. It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative, and inflammatory stresses. Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation), and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators). Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. Finally, the antioxidant response of renal cells in diabetic nephropathy is tackled, with emphasis on targeted therapy. An integrative approach is needed for identifying key molecular networks which control cellular responses triggered by the array of stressors in diabetic nephropathy. This will foster the discovery of reliable biomarkers for early diagnosis and prognosis, and will guide the discovery of new therapeutic approaches for personalized medicine in diabetic nephropathy.

  8. Diagnosis and treatment of patients with IgA nephropathy in Japan

    Directory of Open Access Journals (Sweden)

    Yasuhiko Tomino

    2016-12-01

    Full Text Available Chronic kidney disease (CKD is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycystic kidney disease. IgA nephropathy is characterized by polymeric IgA1 with aberrant galactosylation (galactose-deficient IgA1 increased in the blood and deposited in the glomerular mesangial areas, as well as partially in the capillary walls. The tonsils are important as one of the responsible regions in this disease. The clarification of the mechanism of galactose-deficient IgA1 production will pave the way for the development of novel therapies. The results of future research are eagerly awaited. At present, the most important therapeutic goals in patients with IgA nephropathy are the control of hypertension, the decrease of urinary protein excretion, and the inhibition of progression to end-stage kidney disease. Several investigators have reported that renin–angiotensin–aldosterone system inhibitors reduce levels of urinary protein excretion and preserve renal function in patients with IgA nephropathy. In Japan, tonsillectomy and steroid pulse therapy are more effective for patients with IgA nephropathy.

  9. Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Caroline Pereira Domingueti

    2016-01-01

    Full Text Available This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR < 60 mL/min/1.73 m2, n=65; and without nephropathy (albuminuria < 30 mg/g and GFR ≥ 60 mL/min/1.73 m2, n=60. INF-γ, IL-6, IL-10, and TNF-α plasma levels were determined by flow cytometry. VWF, ADAMTS13 antigen, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay and ADAMTS13 activity was assessed by fluorescence resonance energy transfer assay. Elevated levels of INF-γ, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (P=0.001, P<0.001, P<0.001, P<0.001, and P<0.001, resp.. Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist. INF-γ, TNF-α, and IL-10 significantly correlated with haemostatic biomarkers. Inflammatory and hypercoagulability status are associated with nephropathy in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic nephropathy.

  10. The necessity and effectiveness of mineralocorticoid receptor antagonist in the treatment of diabetic nephropathy.

    Science.gov (United States)

    Sato, Atsuhisa

    2015-06-01

    Diabetes mellitus is a major cause of chronic kidney disease (CKD), and diabetic nephropathy is the most common primary disease necessitating dialysis treatment in the world including Japan. Major guidelines for treatment of hypertension in Japan, the United States and Europe recommend the use of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers, which suppress the renin-angiotensin system (RAS), as the antihypertensive drugs of first choice in patients with coexisting diabetes. However, even with the administration of RAS inhibitors, failure to achieve adequate anti-albuminuric, renoprotective effects and a reduction in cardiovascular events has also been reported. Inadequate blockade of aldosterone may be one of the reasons why long-term administration of RAS inhibitors may not be sufficiently effective in patients with diabetic nephropathy. This review focuses on treatment in diabetic nephropathy and discusses the significance of aldosterone blockade. In pre-nephropathy without overt nephropathy, a mineralocorticoid receptor antagonist can be used to enhance the blood pressure-lowering effects of RAS inhibitors, improve insulin resistance and prevent clinical progression of nephropathy. In CKD categories A2 and A3, the addition of a mineralocorticoid receptor antagonist to an RAS inhibitor can help to maintain 'long-term' antiproteinuric and anti-albuminuric effects. However, in category G3a and higher, sufficient attention must be paid to hyperkalemia. Mineralocorticoid receptor antagonists are not currently recommended as standard treatment in diabetic nephropathy. However, many studies have shown promise of better renoprotective effects if mineralocorticoid receptor antagonists are appropriately used.

  11. Harnessing the immunological properties of stem cells as a therapeutic option for diabetic nephropathy.

    Science.gov (United States)

    D'Addio, Francesca; Trevisani, Alessio; Ben Nasr, Moufida; Bassi, Roberto; El Essawy, Basset; Abdi, Reza; Secchi, Antonio; Fiorina, Paolo

    2014-12-01

    Diabetic nephropathy is the leading and possibly the most devastating complication of diabetes, with a prevalence ranging from 25 to 40 % in diabetic individuals, and as such represents an important challenge for public health worldwide. As a major cause of end-stage renal disease, diabetic nephropathy also accounts for a large proportion of deaths in diabetic individuals. To date, therapeutic options for overt diabetic nephropathy include medical interventions to reduce blood glucose levels and to control blood pressure and proteinuria. Recent evidence suggests a strong role for inflammation in the development and progression of diabetic nephropathy. Various immune cells, cytokines and chemokines have been implicated in the onset of diabetic nephropathy, while immune-related transcription factors and adhesion molecules have been correlated with the establishment of a renal proinflammatory microenvironment. Both inflammation and immune activation may promote severe distress in the kidney, with subsequent increased local fibrosis, ultimately leading to the development of end-stage renal disease. Stem cells are undifferentiated cells capable of regenerating virtually any organ or tissue and bearing important immunoregulatory and anti-inflammatory properties. Due to the aforementioned considerations, significant interest has been ignited with regard to the use of stem cells as novel therapeutics for diabetic nephropathy. Here, we will be examining in detail how anti-inflammatory properties of different populations of stem cells may offer novel therapy for the treatment of diabetic nephropathy.

  12. Association of Leptin-2548G/A polymorphism with diabetic nephropathy in Iranian Azeri Turkish patients

    Directory of Open Access Journals (Sweden)

    Sina Abroon

    2016-12-01

    Full Text Available The association of -2548 G/A polymorphism with diabetes has been discussed in previous studies, but there is no study on nephropathic patients. To investigate the -2548G/Polymorphism as a possible risk factor for incidence of nephropathy in diabetic patients. Distributions of Leptin -2548G/A genotypes were evaluated in 100 diabetic nephropathy and 100 diabetic non-nephropathy Iranian Azeri Turkish patients, using polymerase chain reaction- restriction fragment length polymorphism technique. Also glucose, lipid profile, kidney parameters, insulin and leptin levels were evaluated. The results showed that the GA and AA genotypes could increase nephropathy risk about 2- and 3- fold, respectively (p= 0.034 and 0.009 respectively but considering serum leptin levels as affecting factor eliminated such association. Serum levels of leptin were higher in AA carriers than patients with other genotypes (p<0.05. We found that levels of creatinine and insulin were positively correlated with leptin levels in diabetic non-nephropathy group. GFR levels were negatively correlated with leptin levels in all studied and diabetic non-nephropathy groups. Our findings showed that considering leptin levels as affecting variable, the LEP-2548G/A polymorphism is not associated with nephropathy complication in diabetic patients and the polymorphism may affect through increasing leptin levels.

  13. Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus

    Science.gov (United States)

    Domingueti, Caroline Pereira; Fóscolo, Rodrigo Bastos; Reis, Janice Sepúlveda; Campos, Fernanda Magalhães Freire; Dusse, Luci Maria S.; Carvalho, Maria das Graças; Braga Gomes, Karina; Fernandes, Ana Paula

    2016-01-01

    This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR < 60 mL/min/1.73 m2), n = 65; and without nephropathy (albuminuria < 30 mg/g and GFR ≥ 60 mL/min/1.73 m2), n = 60. INF-γ, IL-6, IL-10, and TNF-α plasma levels were determined by flow cytometry. VWF, ADAMTS13 antigen, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay and ADAMTS13 activity was assessed by fluorescence resonance energy transfer assay. Elevated levels of INF-γ, VWF, ADAMTS13 antigen, D-Dimer, and reduced ADAMTS13 activity/antigen ratio were observed in patients with nephropathy as compared to those without nephropathy (P = 0.001, P < 0.001, P < 0.001, P < 0.001, and P < 0.001, resp.). Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). INF-γ, TNF-α, and IL-10 significantly correlated with haemostatic biomarkers. Inflammatory and hypercoagulability status are associated with nephropathy in type 1 diabetes mellitus and an interrelationship between them may play an important role in pathogenesis of diabetic nephropathy. PMID:26770985

  14. ACE Gene Insertion/Deletion Polymorphism and Type-2 Diabetic Nephropathy in Eastern Indian Population

    Directory of Open Access Journals (Sweden)

    Mithun Sikdar

    2013-02-01

    Full Text Available Background: Nephropathy is one of the major complications among the patients having type 1 or long term Type 2 diabetes and there are various studies that suggest its genetic predisposition. A 287 bp insertion/deletion (I/D polymorphism of the gene encoding angiotensin-I converting enzyme (ACE is shown to have association with diabetic nephropathy. Aim: To identify the association of ACE I/D polymorphism with subjects having diabetic nephropathy.Materials and methods: The present study examined the prevalence of ACE insertion/deletion polymorphism among 91 Bengali individuals from Eastern India. Among them 30 individuals belong to diabetic nephropathy (DN, 30 individuals having diabetes without nephropathy (DM and 31 normal controls. The DNA samples of studied subjects were genotyped using polymerase chain reaction.Results: The frequency of DD, ID and II genotypes in patients having diabetic nephropathy (DN were found to be 26.7%, 53.3% and 20.0% respectively, whereas the same for only diabetic patients (DM were 26.7%, 50.0%and 23.3% respectively. The frequencies of the same genotypes among the normal controls were found to be 9.68%, 64.5% and 25.8% respectively. Inspite of a slightly higher odds ratio for DD genotypes among DM and DN subjects in comparison to the normal group the distribution pattern of DD genotype did not differ significantly within the three cohorts. The frequency of D allele among the patients having diabetic nephropathy, diabetic without nephropathy and control subjects was found to be 0.533, 0.516 and 0.420 respectively. This distribution pattern also did not differ significantly (χ2=1.859, p>0.05.Conclusion: No significant association was found between ACE I/D polymorphism with diabetic nephropathy patients from Bengali caste population.

  15. Atherogenic dyslipidemia in diabetic nephropathy: lipoprotein (a, lipid ratios and atherogenic index

    Directory of Open Access Journals (Sweden)

    Suchitra MM

    2013-08-01

    Full Text Available Background: Atherogenic lipid profile is reported to become pronounced with onset of nephropathy. Lipid ratios also indicate atherogenic dyslipidemia. Lipoprotein (a [(Lp(a] considered as an independent risk factor for cardiovascular diseases (CVD, may play an important role in development and progression of nephropathy in type 2 diabetes mellitus (T2DM. The present study aimed to assess atherogenic dyslipidemia in T2DM and diabetic nephropathy patients. Methods: Total cholesterol (TC, triglycerides(Tgl, high density lipoprotein (HDL, low density lipoprotein (LDL, very low density lipoprotein (VLDL, Lp(a, lipid ratios: TC/HDL, Tgl/HDL, LDL/HDL, non-HDL cholesterol and atherogenic index (AI was assessed in T2DM (n=35, diabetic nephropathy (n=30 and healthy individuals (n=30. Means of biochemical parameters were compared by ANOVA (analysis of variance. Pearson correlation was performed to study the association between parameters. Receiver operating characteristics (ROC curve analysis was done to assess the predictive ability of the variables. Results: Atherogenic dyslipidemia with elevated Lp(a, TC, Tgl, VLDL, LDL, non-HDL cholesterol, lipid ratios, AI and low HDL levels were observed in both T2DM patients with and without nephropathy when compared to controls. Significantly high Tgl/HDL, TC/HDL and AI were observed in diabetic nephropathy when compared to T2DM. Conclusion: T2DM and diabetic nephropathy are associated with dyslipidemia which was more pronounced in diabetic nephropathy. Elevated Lp(a levels may be considered as an independent CVD risk marker in T2DM and diabetic nephropathy patients along with atherogenic lipid ratio indicators. [Int J Res Med Sci 2013; 1(4.000: 455-459

  16. M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy

    Science.gov (United States)

    Beck, Laurence H.; Bonegio, Ramon G.B.; Lambeau, Gérard; Beck, David M.; Powell, David W.; Cummins, Timothy D.; Klein, Jon B.; Salant, David J.

    2009-01-01

    BACKGROUND Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown. METHODS We performed Western blotting of protein extracts from normal human glomeruli with serum samples from patients with idiopathic or secondary membranous nephropathy or other proteinuric or autoimmune diseases and from normal controls. We used mass spectrometry to analyze the reactive protein bands and confirmed the identity and location of the target antigen with a monospecific antibody. RESULTS Serum samples from 26 of 37 patients (70%) with idiopathic but not secondary membranous nephropathy specifically identified a 185-kD glycoprotein in non-reduced glomerular extract. Mass spectrometry of the reactive protein band detected the M-type phospholipase A2 receptor (PLA2R). Reactive serum specimens recognized recombinant PLA2R and bound the same 185-kD glomerular protein as did the monospecific anti-PLA2R antibody. Anti-PLA2R autoantibodies in serum samples from patients with membranous nephropathy were mainly IgG4, the predominant immunoglobulin subclass in glomerular deposits. PLA2R was expressed in podocytes in normal human glomeruli and colocalized with IgG4 in immune deposits in glomeruli of patients with membranous nephropathy. IgG eluted from such deposits in patients with idiopathic membranous nephropathy, but not in those with lupus membranous or IgA nephropathy, recognized PLA2R. CONCLUSIONS A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA2R. PLA2R is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that PLA2R is a major antigen in this disease. PMID:19571279

  17. Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.

    Science.gov (United States)

    Kitada, Munehiro; Kume, Shinji; Takeda-Watanabe, Ai; Kanasaki, Keizo; Koya, Daisuke

    2013-02-01

    Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1-SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency under various stress conditions, such as metabolic or oxidative stress or hypoxia, is implicated in the pathophysiologies of age-related diseases including diabetes, cardiovascular diseases, neurodegenerative disorders and renal diseases. In the kidneys, SIRT1 may inhibit renal cell apoptosis, inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy. In addition, SIRT3 and SIRT6 are implicated in age-related disorders or longevity. In the present review, we discuss the protective functions of sirtuins and the association of sirtuins with the pathophysiology of renal diseases, including diabetic nephropathy.

  18. Extracorporeal shock wave therapy does not improve hypertensive nephropathy.

    Science.gov (United States)

    Caron, Jonathan; Michel, Pierre-Antoine; Dussaule, Jean-Claude; Chatziantoniou, Christos; Ronco, Pierre; Boffa, Jean-Jacques

    2016-06-01

    Low-energy extracorporeal shock wave therapy (SWT) has been shown to improve myocardial dysfunction, hind limb ischemia, erectile function, and to facilitate cell therapy and healing process. These therapeutic effects were mainly due to promoting angiogenesis. Since chronic kidney diseases are characterized by renal fibrosis and capillaries rarefaction, they may benefit from a proangiogenic treatment. The objective of our study was to determine whether SWT could ameliorate renal repair and favor angiogenesis in L-NAME-induced hypertensive nephropathy in rats. SWT was started when proteinuria exceeded 1 g/mmol of creatinine and 1 week after L-NAME removal. SWT consisted of implying 0.09 mJ/mm(2) (400 shots), 3 times per week. After 4 weeks of SWT, blood pressure, renal function and urinary protein excretion did not differ between treated (LN + SWT) and untreated rats (LN). Histological lesions including glomerulosclerosis and arteriolosclerosis scores, tubular dilatation and interstitial fibrosis were similar in both groups. In addition, peritubular capillaries and eNOS, VEGF, VEGF-R, SDF-1 gene expressions did not increase in SWT-treated compared to untreated animals. No procedural complications or adverse effects were observed in control (C + SWT) and hypertensive rats (LN + SWT). These results suggest that extracorporeal kidney shock wave therapy does not induce angiogenesis and does not improve renal function and structure, at least in the model of hypertensive nephropathy although the treatment is well tolerated.

  19. Effect of antihypertensive treatment on progression of incipient diabetic nephropathy

    DEFF Research Database (Denmark)

    Christensen, Cramer; Mogensen, C E

    1985-01-01

    The aim of the study was to clarify whether antihypertensive treatment with a selective beta blocker would have an effect on the progression rate of kidney disease in patients with incipient diabetic nephropathy. Six male patients with juvenile-onset diabetes with incipient nephropathy (urinary...... albumin excretion above 15 micrograms/min and total protein excretion below 0.5 g/24 hr) were treated with metoprolol (200 mg daily). At the start of the antihypertensive treatment the mean age was 32 years +/- 4.2 (SD). The patients were followed a mean 5.4 years +/- 3.1 (SD) with repeated measurements...... of urinary albumin excretion before and during 2.6 years +/- 1.0 (SD) of treatment. The blood pressure was depressed by the treatment (systolic blood pressure from 135 mm Hg +/- 8.6 to 124 mm Hg +/- 6.2, NS; mean blood pressure from 107 mm Hg +/- 7.6 to 97 mm Hg +/- 3.4, 2p less than 0.05; diastolic blood...

  20. The association between vitamin D deficiency and diabetic nephropathy in type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    李冬梅

    2013-01-01

    Objective To evaluate the association between vitamin D deficiency and diabetic nephropathy in type 2 diabetic patients.Methods A total of 594 patients with type2 diabetes were enrolled from the inpatients of the Nanjing Medical University Affiliated Nanjing Hospital.Fasting serum lipid profile,25-hydroxycalciferol vitamin D and urinary albumin excretion rate were investigated.The relationship between nephropathy and vitamin D deficiency (<20μg/L) or insufficiency (20-<30μg/L) was analyzed.Results Nephropathy was found in 177subjects (29.8%) with albuminuria in 141 and proteinu-