WorldWideScience

Sample records for balancing radiation benefits

  1. Balancing radiation benefits and risks: The needs of an informed public

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    The American public`s perceptions regarding ionizing radiation do not always conform to or correlate with scientific evidence. The ultimate purpose of this coordinated Federal effort and report is to increase the public`s knowledge of the benefits and risks associated with ionizing radiation. This report is divided into five sections. The first section, Introduction, discusses the public`s knowledge of radiation, their perceptions of benefits versus risks, and the Federal government`s role in public education. The section also outlines the charge to the Subpanel. Radiation Issues and Public Reactions discusses several radiation issues important to Federal agencies for which public education programs need to be established or enhanced. Federal Programs describes Federal agencies with public education programs on radiation and the nature of the programs they support. Education Issues and Federal Strategies explores the elements identified by the Subpanel as critical to the development and implementation of an effective Federal program in the area of public education on radiation issues and nuclear technologies. An important issue repeatedly brought up during the public sector presentations to the Subpanel was the perceived lack of Federal credibility on radiation issues in the eyes of the public. To some degree, this concern was factored into all of the recommendations developed by the subpanel. The issues discussed in this section include the fragmented nature of Federal radiation programs and the need to improve credibility, promote agency responsiveness, and support the enhancement of scientific literacy. Finally, under Recommendations, the Subpanel discusses its overall findings and conclusions.

  2. Balancing radiation benefits and risks: The needs of an informed public

    International Nuclear Information System (INIS)

    1994-04-01

    The American public's perceptions regarding ionizing radiation do not always conform to or correlate with scientific evidence. The ultimate purpose of this coordinated Federal effort and report is to increase the public's knowledge of the benefits and risks associated with ionizing radiation. This report is divided into five sections. The first section, Introduction, discusses the public's knowledge of radiation, their perceptions of benefits versus risks, and the Federal government's role in public education. The section also outlines the charge to the Subpanel. Radiation Issues and Public Reactions discusses several radiation issues important to Federal agencies for which public education programs need to be established or enhanced. Federal Programs describes Federal agencies with public education programs on radiation and the nature of the programs they support. Education Issues and Federal Strategies explores the elements identified by the Subpanel as critical to the development and implementation of an effective Federal program in the area of public education on radiation issues and nuclear technologies. An important issue repeatedly brought up during the public sector presentations to the Subpanel was the perceived lack of Federal credibility on radiation issues in the eyes of the public. To some degree, this concern was factored into all of the recommendations developed by the subpanel. The issues discussed in this section include the fragmented nature of Federal radiation programs and the need to improve credibility, promote agency responsiveness, and support the enhancement of scientific literacy. Finally, under Recommendations, the Subpanel discusses its overall findings and conclusions

  3. Radiation: cost or benefit?

    International Nuclear Information System (INIS)

    Crouch, D.

    1988-01-01

    In a previous issue of SCRAM it was argued that the apparent increased incidence of child leukaemia around nuclear power stations could have been caused by radioactive discharges into the environment. The National Radiological Protection Board (NRPB) claim that the known levels of contamination could not be responsible for the observed cancer rates. NRPB estimates of radiation risk are, however, considered to be underestimates. The NRPB is criticised for its study of the Sellafield workforce which excluded ex-employees and which revealed, when a statistical mistake was put right, a significant excess of myeloma amongst the Windscale workforce. The radiation protection philosophy of the NRPB is based on a cost benefit analysis which balances the cost of protection against the benefits of power generation. Criticism is made of NRPB, not only for ignoring long-term risks and costs but also for suggesting that some levels of radiation exposure are acceptable. The Board is also accused of not being independent of the nuclear industry. (UK)

  4. Ionizing radiation: benefits vs. risks

    International Nuclear Information System (INIS)

    Wagner, H.N. Jr.

    1986-01-01

    No one has been identifiably injured by radiation within the levels set by the NCRP and ICRP in 1934. This fact and the level of natural radiation (average dose 102 millirems/year) help provide standards against which the authors can view the relative increases in exposure from manmade sources of radiation. Because one person in five in the US will die of cancer from all causes, it is impossible to detect small increases in some types of cancer from radiation. A valid assumption is that any exposure to radiation carries some possibility of harm and should be kept below the level of the expected benefits. More is known about radiation toxicity than about any other potentially toxic substances. An obstacle to progress in the use of radioactive materials in biology and medicine is an exaggerated impression by the public of the risk of radiation. Several studies indicate that the public perceives the risk of radiation to be the greatest of all societal risks and at times does not distinguish peaceful from military uses of radiation. It behooves scientists and physicians to inform the public about the benefits as well as the risks of procedures involving radiation

  5. Radiation balances and the solar constant

    Science.gov (United States)

    Crommelynck, D.

    1981-01-01

    The radiometric concepts are defined in order to consider various types of radiation balances and relate them to the diabetic form of the energy balance. Variability in space and time of the components of the radiation field are presented. A specific concept for sweeping which is tailored to the requirements is proposed. Finally, after establishing the truncated character of the present knowledge of the radiation balance. The results of the last observations of the solar constant are given. Ground and satellite measurement techniques are discussed.

  6. Radiation dose in paediatric computed tomography: risks and benefits

    African Journals Online (AJOL)

    The best available risk estimates suggest that paediatric CT will result in significantly increased lifetime radiation risk over adult CT. Studies have shown that lower milliampere-second (mAs) settings can be used for children without significant loss of information. Although the risk–benefit balance is still strongly tilted toward ...

  7. Radiation balance of an alfalfa crop in Saudi Arabia

    International Nuclear Information System (INIS)

    Al-Yemeni, M.N.; Grace, J.

    1995-01-01

    Short-wave reflectivity or albedo is an important component of net radiation which represents the major determinant of radiation balance of crop surface. This study was conducted on an irrigated alfalfa crop field at Al-Kharj agricultural area in Saudi Arabia, grown according to normal agricultural practices. Data on radiation balance and crop cover were collected over a number of days from March to October 1986, crop albedo varying from 0–4 in early morning to 0–20 at noon, the overall mean value of the crop albedo being estimated at 0–26. The relation between the individual components of radiation balance was studied, and a significant correlation between incident radiation and net radiation was found. Possible causes responsible for changes in crop albedo were discussed. (author)

  8. Pricing Externalities to Balance Public Risks and Benefits of Research.

    Science.gov (United States)

    Farquhar, Sebastian; Cotton-Barratt, Owen; Snyder-Beattie, Andrew

    How should scientific funders evaluate research with public health risks? Some risky work is valuable, but accepting too much risk may be ethically neglectful. Recent controversy over H5N1 influenza experiments has highlighted the difficulty of this problem. Advocates of the research claim the work is needed to understand pandemics, while opponents claim that accidents or misuse could release the very pandemic the work is meant to prevent. In an attempt to resolve the debate, the US government sponsored an independent evaluation that successfully produced a quantitative estimate of the risks involved, but only a qualitative estimate of the benefits. Given the difficulties of this "apples-to-oranges" risk-benefit analysis, what is the best way forward? Here we outline a general approach for balancing risks and benefits of research with public risks. Instead of directly comparing risks and benefits, our approach requires only an estimate of risk, which is then translated into a financial price. This estimate can be obtained either through a centrally commissioned risk assessment or by mandating liability insurance, which allows private markets to estimate the financial burden of risky research. The resulting price can then be included in the cost of the research, enabling funders to evaluate grants as usual-comparing the scientific merits of a project against its full cost to society. This approach has the advantage of aligning incentives by assigning costs to those responsible for risks. It also keeps scientific funding decisions in the hands of scientists, while involving the public on questions of values and risk experts on risk evaluation.

  9. Radiation balance in the sweet sorghum crop

    International Nuclear Information System (INIS)

    Assis, F.N. de; Mendez, M.E.G.; Martins, S.R.; Verona, L.A.

    1987-01-01

    The fluxes of incident solar radiation, reflected and net radiation were measured during the growing cicle of two fields of sweet sorghum (Sorghum bicolor L.), cus. BR-501 and BR-503, maintained under convenient irrigation level. Resultant data allowed to estimate the crop albedo as well as the estimates of Rn. (M.A.C.) [pt

  10. Adrenaline in anaphylaxis treatment. Balancing benefits and harms.

    Science.gov (United States)

    Cervellin, Gianfranco; Sanchis-Gomar, Fabian; Lippi, Giuseppe

    2016-06-01

    Although anaphylaxis is a relatively common disorder, clinicians and scientists have debated on how to best define and manage this condition. The current recommendations are focused on the central role of adrenaline, but evidence in support of this therapeutic approach is modest, mainly for the lack of well-designed trials. Conversely, serious adverse effects are commonly reported following adrenaline use, especially when given intravenously. These include hypertension, ventricular arrhythmias, myocardial infarction, pulmonary edema. Anaphylaxis treatment, with special focus on adrenaline utilization, both in pre-hospital and in-hospital settings. Aim is to examine in depth the balance between benefits and harms of this important drug. Due to the lack of solid evidence supporting the use of adrenaline in patients with anaphylaxis, except in severe cases, the strength of recommendations should be readdressed, limiting administration to selected categories of patients. Caregivers should promptly act in pre-hospital setting, given the shortness of time and lack of technology. In the hospital setting, and more specifically in the ED, clinicians should consider the prompt use of adrenaline in severe anaphylaxis cases, but they should also be able to judiciously wait in the vast majority of milder anaphylactic reactions, which may resolve spontaneously.

  11. Risk and benefits in ionizing radiation uses

    International Nuclear Information System (INIS)

    2010-08-01

    This meeting include: A tribute to Szeinfeld, presentation software for population dose, impact on radiation protection, radiation protection hospital and population exposed workers, regulation and licensing. radiological emergencies, risk, inspection, external radiotherapy and radiation protection with photons, brachytherapy, industrial, environmental monitoring, food irradiation, nuclear power, nuclear medicine.

  12. Population-based mammography screening below age 50: Balancing radiation-induced vs prevented breast cancer deaths

    NARCIS (Netherlands)

    R. de Gelder (Rianne); G. Draisma (Gerrit); E.A.M. Heijnsdijk (Eveline); H.J. de Koning (Harry)

    2011-01-01

    textabstractIntroduction:Exposure to ionizing radiation at mammography screening may cause breast cancer. Because the radiation risk increases with lower exposure age, advancing the lower age limit may affect the balance between screening benefits and risks. The present study explores the

  13. Energy balance in coherent electromagnetic radiation

    CERN Document Server

    Coisson, R

    1994-01-01

    Bunched charges, as in the 'free electron laser', radiate more energy than unbunched ones. For a better understanding of how the forces between particles determine the conservation of energy, we take the simple model of two charges within a wavelength of a sinusodoidal wave, and show that the relative phase of the particle's motion with respect to the wave is modified by the force between the two particles, and this explains the extra work done by the wave. The phase shift is proportional to the emitted field and depends on the retardation (particle distance divided by speed of light), and turns out to be independent of distance. (author)

  14. Balancing risks and benefits fairly across generations: cost/benefit considerations

    International Nuclear Information System (INIS)

    Catron, B.L.

    1994-01-01

    This paper has been prepared by the OECD Nuclear Energy Agency Workshop on the environmental and ethical aspects of long-lived radioactive waste disposal. The workshop is intended as a step toward preparation of a collective opinion on deep geological storage of nuclear waste. As requested, this paper answers to the following specific questions : 1) Discounting of costs with time is a widely applied technique in the evaluation of the impact of economic and industrial decisions. Could or should discounting of long-term health risks due to radioactive waste disposal be envisaged? 2) Is it possible to assess what is passed on to future generations in terms of health risks, other detriments and possible benefits of all sorts, directly or indirectly? Should such an assessment be applied generically to human activities in a broad sense or should it concern only waste disposal issues? 3) How can the immediate needs of the current generations for example for energy generation or public health protection be balanced with inter generational equity requirements in the very long term? 4) Are resources devoted to assuring safety of radioactive waste disposal appropriately balanced with risks given that these resources could be applied to other societal goals? 5) Is it preferable to take all physical actions today to minimize any bequest of liabilities for waste management actions to future generations. If not how should financial assets be set aside to meet the liabilities? 6) What guidelines and principles should we follow to balance these risks? Does the proposition that we should not expose future generations to a risk that is not acceptable today appropriately address this issue? 7) Should measures of risk acceptability be considered in the context of individual rights or local rights or the collective rights of the population? 8) What measures are necessary in the siting of repositories to assure that disadvantaged populations do not bear disproportionate burdens? 9) Is

  15. Radiation risks and benefits: politics and morality

    International Nuclear Information System (INIS)

    Maxey, M.N.

    1983-01-01

    The bioethical framework from which moral reasoning concerning nuclear technology has been derived is both seriously flawed and conceptually inadequate. The reasons are examined and are arranged in response to three questions. First, what is the status of alleged scientific evidence from which moral conclusions about the unacceptability of man-made radiation exposures are derived. Secondly, what criticisms of risk assessment reasoning are pertinent to ethical reflection. Finally, what revisions in an ethical framework are necessary if risk estimates of low-dose radiation exposure are to be conducted properly

  16. Benefits of radiation processing to public health

    Science.gov (United States)

    Kampelmacher, E. H.

    The problem of foodborne diseases, in which especially food of animals origin and the infected animal is involved, is reviewed. Salmonella and Campylobacter contamination of meat and poultry may today, together with parasites in meat and fish be considered as an increasing public health problem. Control and prevention measures, especially including radiation processing is summarized and with regard to specific micro-organisms and parasites and to various food commodities suitable for irradiation purposes. The possibilities of this new processing technique for reduction and probably elimination of pathogens and parasites are discussed and recommendations are given for practical application of radiation in order to eliminate health risks eliminating from contaminated food.

  17. Physiological benefits from low levels of ionizing radiation

    International Nuclear Information System (INIS)

    Luckey, T.D.

    1982-01-01

    Extensive literature indicates that minute doses of ionizing radiation benefit animal growth and development, fecundity, health and longevity. Specific improvements appear in neurologic function, growth rate and survival of young, wound healing, immune competence, and resistance to infection, radiation morbidity, and tumor induction and growth. Decreased mortality from these debilitating factors results in increased average life span following exposure to minute doses of ionizing radiation. The above phenomena suggest the possibility that ionizing radiation may be essential for life. Limited data with protozoa suggest that reproduction rates decrease when they are maintained in subambient radiation environments. This may be interpreted to be a radiation deficiency. Evidence must now be obtained to determine whether or not ionizing radiation is essential for growth, development, nutrient utilization, fecundity, health and longevity of higher animals. Whether or not ionizing radiation is found to be essential for these physiologic functions, the evidence reviewed indicates that the optimal amount of this ubiquitous agent is imperceptibly above ambient levels. (author)

  18. Analysis of the temporal variation of radiation balance components in arid rice (Oryza sativa L.) culture

    International Nuclear Information System (INIS)

    Prates, J.E.; Coelho, D.T.; Steinmetz, S.

    1988-01-01

    The time variation of measured radiation balance components in a cultived rice area (Oryza sativa L.) under arid conditions in the Brazil central-west region was analysed. The relation between global solar radiation, radiation balance, reflected radiation and terrestrial effective radiation in three different stages of the culture development: vegetative stage; blooming and maturation, was determined. (M.C.K.) [pt

  19. Cost benefit analysis for occupational radiation exposure

    International Nuclear Information System (INIS)

    Caruthers, G.F.; Rodgers, R.C.; Donohue, J.P.; Swartz, H.M.

    1978-01-01

    In the course of system design, many decisions must be made concerning different aspects of that particular system. The design of systems and components in a nuclear power plant has the added faction of occupational exposure experienced as a result of that design. This paper will deal with the different methods available to factor occupational exposure into design decisions. The ultimate goal is to have exposures related to the design 'As Low As Reasonably Achievable' or ALARA. To do this an analysis should be performed to show that the cost of reducing exposures any further cannot be justified in a cost-benefit analysis. In this paper examples will be given that will show that it is possible to change to a design which would increase occupational exposure somewhat but would increase the benefit over the cost of the extra exposure received. It will also be shown that some changes in design or additional equipment could be justified due to a reduction in exposure while some changes could not be justified on a reduction in exposure aspect alone but are justified on a time saving aspect such as during a refueling outage. (author)

  20. Benefits of balancing method for component RAW importance measure

    International Nuclear Information System (INIS)

    Kim, Kil Yoo; Yang, Joon Eon

    2005-01-01

    In the Risk Informed Regulation and Applications (RIR and A), the determination of risk significant Structure, System and Components (SSCs) plays an important role, and importance measures such as Fussell-Vesely (FV) and RAW (Risk Achievement Worth) are widely used in the determination of risk significant SSCs. For example, in the Maintenance Rule, Graded Quality Assurance(GQA) and Option 2, FV and RAW are used in the categorization of SSCs. Especially, in the GQA and Option 2, the number of SSCs to be categorized is too many to handle, so the FVs and RAWs of the components are practically derived in a convenient way with those of the basic events which have already been acquired as PSA (Probabilistic Safety Assessment) results instead of by reevaluating the fault tree/event tree of the PSA model. That is, the group FVs and RAWs for the components are derived from the FVs and RAWs of the basic events which consist of the group. Here, the basic events include random failure, Common Cause Failure (CCF), test and maintenance, etc. which make the system unavailable. A method called 'Balancing Method' which can practically and correctly derive the component RAW with the basic event FVs and RAWs even if CCFs exists as basic events was introduced in Ref.. However, 'Balancing Method' has other advantage, i.e., it can also fairly correctly derive component RAW using fault tree without using basic events FVs and RAWs

  1. In the balance. The social costs and benefits of PV

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, C. [ECN Solar Energy, Petten (Netherlands)

    2013-10-16

    For more than a decade, the growth in PV markets surpassed expectations. Then, in 2012, the European market declined for the first time compared with the previous year. As policymakers' support for PV hesitates over the costs to society of this technology, it is timely to take an overview of the social costs and benefits, also referred to as the 'external costs', of PV electricity. In this article, these costs are put into perspective vis-a-vis those associated with conventional electricity-generating technologies. The external costs of electricity can be broken down into: (1) the environmental and health costs; (2) the costs of subsidies and energy security; and (3) the costs for grid expansion and reliability. Included in these costs are the increased insurance, health, social and environmental costs associated with damages to health, infrastructure and environment, as well as tax payments that subsidize producers of electricity or fuels, their markets and the electricity infrastructure. A life cycle assessment (LCA) of the environmental impact is used in the quantification of the associated environmental and health costs. Because the environmental footprint of PV electricity is highly dependent on the electricity mix used in PV module fabrication, the environmental indicators are calculated for PV electricity manufactured using different electricity mixes, and compared with those for the European electricity mix (UCTE), and electricity generated by burning 100% coal or 100% natural gas. In 2012 USD, coal electricity requires 19-29 eurocent/kWh above the market price, compared with 1-1.6 eurocent/kWh for PV manufactured with 100% coal electricity. The sum of the subsidies, avoided fossil-fuel imports and energy security, and the economic stimulation associated with PV electricity deployment, amounts to net external benefits. Integrating high penetrations of renewables, with the same reliability as we have today, appears to be fully feasible and

  2. Spectral radiation balance of absorbing aerosols over clouds

    Science.gov (United States)

    Stammes, Piet; de Graaf, Martin; Deneke, Hartwig

    2017-04-01

    Absorption by aerosols, like smoke and desert dust, may lead to strong atmospheric warming, surface cooling, and cloud dynamical responses. Therefore, detection of absorbing aerosols and assessment of their radiative effects is important. However, absorbing aerosols are difficult to detect, especially in cloudy scenes. Here we use a satellite detection technique which can be used to determine the spectral absorption effects of smoke aerosols over clouds, using the fact that aerosols have a much stronger effect at UV and visible wavelengths than at longer wavelengths. We also analyse the shortwave radiative balance of absorbing aerosols over clouds. We have developed a technique of measuring aerosols from their absorption effect using multi-spectral satellite data (De Graaf et al., JGR, 2012). Using a wide spectral range, from the UV (300-400 nm) up to the shortwave (SW) IR (1000-1750 nm), it is possible to distinguish the absorption by aerosols from the scattering by clouds. No microphysical assumptions are needed for the aerosols, except that their absorption must vanish at long wavelengths. With this method, called the Differential Aerosol Absorption (DAA) technique, which was applied to SCIAMACHY satellite data, we measured the direct radiative effect of absorbing biomass burning aerosols over clouds in the South-East Atlantic. We measured instantaneous direct radiative effects by the aerosols of the order of 100 W/m2 at top-of-atmosphere. The spectral radiation balance at both top-of-atmosphere and surface is needed to estimate the amount of absorption inside the aerosol layer. We therefore perform a simulation study, using accurate spectral RT modelling, in which we compute the profile of absorption in the aerosol layer. We find that the atmospheric absorption characteristics cannot be measured only from satellite by using reflected light, also the transmission at the surface has to be measured. Therefore, field campaigns are needed in addition to satellite

  3. Instrumentation and control balancing the risks and benefits of modernization

    International Nuclear Information System (INIS)

    Doshi, P.K.; Rawlins, D.H.; Falascino, J.A.

    1996-01-01

    This paper examines the benefits and risks of modernization of instrumentation and control (I and C) systems for nuclear power plants. It will draw conclusions on how to proceed with such modernization across the spectrum from operating reactors to new plant designs. Lessons learned from Westinghouse's application of digital systems to the Temelin Nuclear Power Plant in the Czech Republic, and other nuclear plant upgrades will be used to support principles and conclusions drawn in the paper. A long term view of the modernization program is essential, even if piecemeal or individual upgrades are envisioned. A framework for considering these risks and goals into a long range strategic plan will be presented. The framework will be presented in the form of I and C architectures which permit long term growth, planning ahead for technological obsolescence, selectron of suppliers for term relationships, and effective integration of individual upgrades. Potential upgrade areas will be summarized for functional improvements, I and C hardware upgrades, and man-machine interface improvements. Examples from Westinghouse's I and C experience will be presented to clarify the principles and framework described in the paper. Lessons learned from the application of the Eagle product line to operating reactors and the emergence of distributed computer information systems as an integration vehicle for I and C upgrades will be discussed. Westinghouse is currently modernizing the Temelin Nuclear Power Plant I and C system in the Czech Republic. An overview of this program will be included as it relates to the modernization framework presented in the paper. (authors)

  4. Economic benefits analysis of listed companies in radiation processing

    International Nuclear Information System (INIS)

    Zhang Yingming; Xu Tao; Zhang Yue; Yang Bin; Zhao Wenying

    2012-01-01

    Radiation processing industry is an important part of civilian nuclear technology and develop rapidly during the past decade. Radiation modification of new materials industries use new technology to promote new product development and application and get good economic benefit. There are problems and bottlenecks during the development, such as how to implement the guideline of optimize the industrial structure and upgrade the product, and adapt the market develop law and need. By analysing the typical listed companies in this field together with the domestic economic development condition and future situation, we give the development strategy and method in the future. (authors)

  5. Evaluating the UK and Dutch defined benefit policies using the holistic balance sheet framework

    NARCIS (Netherlands)

    Chen, Z.; Pelsser, A.; Ponds, E.H.M.

    This paper compares the UK and Dutch occupational defined-benefit pension policies using the holistic balance sheet (HBS) framework. The UK DB pension system differs from the Dutch one in terms of the steering tools and adjustment mechanisms. In addition to the sponsor guarantee, the UK system has

  6. Health Benefits of Exposure to Low-dose Radiation.

    Science.gov (United States)

    Rithidech, Kanokporn Noy

    2016-03-01

    Although there is no doubt that exposure to high doses of radiation (delivered at a high dose-rate) induces harmful effects, the health risks and benefits of exposure to low levels (delivered at a low dose-rate) of toxic agents is still a challenging public health issue. There has been a considerable amount of published data against the linear no-threshold (LNT) model for assessing risk of cancers induced by radiation. The LNT model for risk assessment creates "radiophobia," which is a serious public health issue. It is now time to move forward to a paradigm shift in health risk assessment of low-dose exposure by taking the differences between responses to low and high doses into consideration. Moreover, future research directed toward the identification of mechanisms associated with responses to low-dose radiation is critically needed to fully understand their beneficial effects.

  7. Work–life balance policies: Challenges and benefits associated with implementing flexitime

    Directory of Open Access Journals (Sweden)

    Caroline Downes

    2011-02-01

    Full Text Available Orientation: Helping employees to balance their work and family lives is a business imperative. Work–life balance policies (like flexitime aim to support employees to do so. However, implementing these policies is problematic.Research purpose: The aim of this article is to report on the challenges and benefits associated with implementing flexitime as a work–life balance policy.Motivation for the study: Organisations must develop and implement work–life balance policies. This requires human resource practitioners to investigate and understand experiences and perceptions about the challenges and benefits of flexitime.Research design, approach and method: The researcher used a qualitative research design with an exploratory approach. She drew a nonprobability purposive and voluntary sample (n = 15 from the financial sector. She used semi-structured in-depth interviews to collect the data and conducted content analyses to analyse and interpret them.Main findings: The researcher extracted four main themes (individual and general challenges, the aspects organisations need to implement flexitime effectively and the benefits that would follow its implementation from the data. Its benefits vary from work–life balance to employee loyalty and commitment. Some challenges are maintaining productivity, a shortage of critical resources and understanding flexitime.Practical/managerial implications: The research identified requirements that human resource practitioners should attend to in order to ensure that organisations use flexitime more effectively.Contribution/value-add: The researcher obtained unique findings about the minimum requirements for implementing flexitime effectively. They could assist organisations to address the challenges that employees face.

  8. Work–life balance policies: Challenges and benefits associated with implementing flexitime

    Directory of Open Access Journals (Sweden)

    Caroline Downes

    2011-10-01

    Research purpose: The aim of this article is to report on the challenges and benefits associated with implementing flexitime as a work–life balance policy. Motivation for the study: Organisations must develop and implement work–life balance policies. This requires human resource practitioners to investigate and understand experiences and perceptions about the challenges and benefits of flexitime. Research design, approach and method: The researcher used a qualitative research design with an exploratory approach. She drew a nonprobability purposive and voluntary sample (n = 15 from the financial sector. She used semi-structured in-depth interviews to collect the data and conducted content analyses to analyse and interpret them. Main findings: The researcher extracted four main themes (individual and general challenges, the aspects organisations need to implement flexitime effectively and the benefits that would follow its implementation from the data. Its benefits vary from work–life balance to employee loyalty and commitment. Some challenges are maintaining productivity, a shortage of critical resources and understanding flexitime. Practical/managerial implications: The research identified requirements that human resource practitioners should attend to in order to ensure that organisations use flexitime more effectively. Contribution/value-add: The researcher obtained unique findings about the minimum requirements for implementing flexitime effectively. They could assist organisations to address the challenges that employees face.

  9. Mass balance re-analysis of Findelengletscher, Switzerland; benefits of extensive snow accumulation measurements

    Directory of Open Access Journals (Sweden)

    Leo eSold

    2016-02-01

    Full Text Available A re-analysis is presented here of a 10-year mass balance series at Findelengletscher, a temperate mountain glacier in Switzerland. Calculating glacier-wide mass balance from the set of glaciological point balance observations using conventional approaches, such as the profile or contour method, resulted in significant deviations from the reference value given by the geodetic mass change over a five-year period. This is attributed to the sparsity of observations at high elevations and to the inability of the evaluation schemes to adequately estimate accumulation in unmeasured areas. However, measurements of winter mass balance were available for large parts of the study period from snow probings and density pits. Complementary surveys by helicopter-borne ground-penetrating radar (GPR were conducted in three consecutive years. The complete set of seasonal observations was assimilated using a distributed mass balance model. This model-based extrapolation revealed a substantial mass loss at Findelengletscher of -0.43m w.e. a^-1 between 2004 and 2014, while the loss was less pronounced for its former tributary, Adlergletscher (-0.30m w.e. a^-1. For both glaciers, the resulting time series were within the uncertainty bounds of the geodetic mass change. We show that the model benefited strongly from the ability to integrate seasonal observations. If no winter mass balance measurements were available and snow cover was represented by a linear precipitation gradient, the geodetic mass balance was not matched. If winter balance measurements by snow probings and snow density pits were taken into account, the model performance was substantially improved but still showed a significant bias relative to the geodetic mass change. Thus the excellent agreement of the model-based extrapolation with the geodetic mass change was owed to an adequate representation of winter accumulation distribution by means of extensive GPR measurements.

  10. The energy balance experiment EBEX-2000. Part III: Behaviour and quality of the radiation measurements

    NARCIS (Netherlands)

    Kohsiek, W.; Liebethal, C.; Foken, T.; Vogt, R.; Oncley, S.P.; Bernhofer, C.; Debruin, H.A.R.

    2007-01-01

    An important part of the Energy Balance Experiment (EBEX-2000) was the measurement of the net radiation and its components. Since the terrain, an irrigated cotton field, could not be considered homogeneous, radiation measurements were made at nine sites using a variety of radiation instruments,

  11. Health benefits of Tai Chi exercise: improved balance and blood pressure in middle-aged women.

    Science.gov (United States)

    Thornton, Everard W; Sykes, Kevin S; Tang, Wai K

    2004-03-01

    Tai Chi has been widely practiced as a Chinese martial art that focuses on slow sequential movements, providing a smooth, continuous and low intensity activity. It has been promoted to improve balance and strength and to reduce falls in the elderly, especially those 'at risk'. The potential benefits in healthy younger age cohorts and for wider aspects of health have received less attention. The present study documented prospective changes in balance and vascular responses for a community sample of middle-aged women. Seventeen relatively sedentary but healthy normotensive women aged 33-55 years were recruited into a three times per week, 12-week Tai Chi exercise programme. A further 17 sedentary subjects matched for age and body size were recruited as a control group. Dynamic balance measured by the Functional Reach Test was significantly improved following Tai Chi, with significant decreases in both mean systolic (9.71 mmHg) and diastolic (7.53 mmHg) blood pressure. The data confirm that Tai Chi exercise can be a good choice of exercise for middle-aged adults, with potential benefits for ageing as well as the aged.

  12. Cost benefit effect of application of radiation in JAERI

    International Nuclear Information System (INIS)

    Kazuaki Yanagisawa

    2009-01-01

    It is important for us to show accountability and transparency of nuclear funds invested to Japan Atomic Energy Research Institute (JAERI, now JAEA). We have not only to simply present the R and D outputs to tax payers by the bibliometric methods as measurable as possible but also to carry out a cost benefit analysis to show quantitatively the effect of economic representation which enables to make efficient allotment of resources. The task is heavy but unavoidable. In the present work, a cost benefit effect (CBE) of application of radiation known as one of big R and D project conducted in JAERI-Takasaki Branch is focused on. After defining CBE as Market Creation Effect (MCE) / Total amounts of investment, one tried to reveal the long-term CBE as long as 44 years. It is found that 31 research items, such as radial tires, cross-linking of wires, sterilization, and sterile of melon flies were succeeded to create markets in industrial and agricultural fields. Estimated MCE of those was totaled to 1,125 million dollars (M$). On the other hand, investment was 396 M$ for personnel (4,092 man/year) and 509 M$ for research costs. It totaled as 905 M$. Therefore, CBE for application of radiation in Takasaki Branch shall be 1,125/905=1.2. The mission dictated by the Long-Range Research Plan for Nuclear settled by the Atomic Energy Commission involves a lot of R and D tasks including partly the technical difficulties as well as partly the deep uncertainties for future prospects. JAERI is a national research institute and this figure may be regarded as reasonably acceptable because of many high risk and complex tasks were conducted successfully resulting in the creation of 31 new markets. It contributed to the increase of GDP. (Author)

  13. Using the balanced scorecard to characterize benefits of integration in the safety net.

    Science.gov (United States)

    Wells, Rebecca; Weiner, Bryan

    2005-05-01

    The purpose of this study was to develop a comprehensive framework depicting the potential benefits of integration among health-care providers that serve vulnerable populations. Research teams interviewed participants in 12 integrated functions across seven community health-centre-led networks. Functions included clinical processes; managed care contracting; and administrative services such as human resources, finance, and information systems. Using a Balanced Scorecard framework, benefits were identified across financial, customer, internal business, and learning and growth perspectives. Financial benefits were more frequently cited relative to managed care and administrative functions than relative to clinical functions. Clinical functions were frequently characterized by perceived improvements in patient care quality, while managed-care functions appeared to yield most benefits in access. Administrative functions were most often associated with improvements in internal business operations. There were substantial findings in learning and growth across all three types of integration, in keeping with the early stages of the integrated functions in the study. Findings imply that integration among health-care providers yields a wide range of benefits, but not necessarily quickly or financial in nature.

  14. Modeling the radiation balance within a planted trench system

    Science.gov (United States)

    Kramer, Isaac; Agam, Nurit; Berliner, Pedro

    2017-04-01

    Micro-catchment systems (MCs) are designed to harvest and utilize rainwater, with the aim of supporting tree growth in arid regions. While MCs were traditionally built with shallow infiltration basins, recent research indicates that MCs with deeper basins retain more water than MCs with shallower basins, and that trees grown in deeper MCs outperform those grown in shallow MCs. This may be partially because the flux of incoming shortwave radiation reaching the surface is decreased in deeper basins. The degree to which the incoming radiation reaching the floor of the MC is reduced, however, depends on the system's dimensions and orientation, geographical location, canopy geometry, soil properties, date, and time. Existing radiation models are either capable of modeling radiation penetration into trenches, or describe transmission of radiation through canopy. None can describe the penetration of radiation through canopy into a trench. The goal of our research was to model the incoming shortwave and longwave radiation flux densities reaching a MC floor in which trees are planted. The model calculates the incoming shortwave and longwave radiation at any given point on the trench floor. In calculating the incoming shortwave radiation, the model considers direct radiation, diffuse radiation, and direct and diffuse radiation reflected from the walls of the MC system. The model also accounts for possible shading and attenuation of the radiation caused by the presence of a canopy in the system. Validation of the model is performed by comparing measured incoming shortwave radiation to modeled outputs. The measurements are conducted at various positions within existing trenches with width of 1 m and length of 12 m, in which three 6-year old olive trees are grown, with 4 m spacing between trees. The flexibility of the model and the ability to change the trench configurations will help enable the maximization of water use efficiency inside MC systems.

  15. Knowledge synthesis of benefits and adverse effects of measles vaccination: the Lasbela balance sheet.

    Science.gov (United States)

    Ledogar, Robert J; Fleming, John; Andersson, Neil

    2009-10-14

    In preparation for a cluster-randomized controlled trial of a community intervention to increase the demand for measles vaccination in Lasbela district of Pakistan, a balance sheet summarized published evidence on benefits and possible adverse effects of measles vaccination. The balance sheet listed: 1) major health conditions associated with measles; 2) the risk among the unvaccinated who contract measles; 3) the risk among the vaccinated; 4) the risk difference between vaccinated and unvaccinated; and 5) the likely net gain from vaccination for each condition. Two models revealed very different projections of net gain from measles vaccine. A Lasbela-specific combination of low period prevalence of measles among the unvaccinated, medium vaccination coverage and low vaccine efficacy rate, as revealed by the baseline survey, resulted in less-than-expected gains attributable to vaccination. Modelled on estimates where the vaccine had greater efficacy, the gains from vaccination would be more substantial. Specific local conditions probably explain the low rates among the unvaccinated while the high vaccine failure rate is likely due to weaknesses in the vaccination delivery system. Community perception of these realities may have had some role in household decisions about whether to vaccinate, although the major discouraging factor was inadequate access. The balance sheet may be useful as a communication tool in other circumstances, applied to up-to-date local evidence.

  16. Knowledge synthesis of benefits and adverse effects of measles vaccination: the Lasbela balance sheet

    Directory of Open Access Journals (Sweden)

    Andersson Neil

    2009-10-01

    Full Text Available Abstract Background In preparation for a cluster-randomized controlled trial of a community intervention to increase the demand for measles vaccination in Lasbela district of Pakistan, a balance sheet summarized published evidence on benefits and possible adverse effects of measles vaccination. Methods The balance sheet listed: 1 major health conditions associated with measles; 2 the risk among the unvaccinated who contract measles; 3 the risk among the vaccinated; 4 the risk difference between vaccinated and unvaccinated; and 5 the likely net gain from vaccination for each condition. Results Two models revealed very different projections of net gain from measles vaccine. A Lasbela-specific combination of low period prevalence of measles among the unvaccinated, medium vaccination coverage and low vaccine efficacy rate, as revealed by the baseline survey, resulted in less-than-expected gains attributable to vaccination. Modelled on estimates where the vaccine had greater efficacy, the gains from vaccination would be more substantial. Conclusion Specific local conditions probably explain the low rates among the unvaccinated while the high vaccine failure rate is likely due to weaknesses in the vaccination delivery system. Community perception of these realities may have had some role in household decisions about whether to vaccinate, although the major discouraging factor was inadequate access. The balance sheet may be useful as a communication tool in other circumstances, applied to up-to-date local evidence.

  17. Fears, feelings, and facts: interactively communicating benefits and risks of medical radiation with patients.

    Science.gov (United States)

    Dauer, Lawrence T; Thornton, Raymond H; Hay, Jennifer L; Balter, Rochelle; Williamson, Matthew J; St Germain, Jean

    2011-04-01

    As public awareness of medical radiation exposure increases, there has been heightened awareness among patients and physicians of the importance of holistic benefit-and-risk discussions in shared medical decision making. We examine the rationale for informed consent and risk communication, draw on the literature on the psychology of radiation risk communication to increase understanding, examine methods commonly used to communicate radiation risk, and suggest strategies for improving communication about medical radiation benefits and risk.

  18. Some results of radiative balance in atmospheres with clouds

    International Nuclear Information System (INIS)

    Anduckia Avila, Juan Carlos; Pelkowski, Joaquin

    2000-01-01

    Vertical profiles of temperature for a semi grey three-Layer atmosphere are established using a radiative equilibrium condition. The approximation contains the greenhouse effect, scattering by clouds in one direction and isotropic diffuse reflection at the planet's surface. Absorption of short- wave radiation is also considered in one of the three layers. Similar models are contained therein

  19. Measuring the Earth's global radiation balance through orbital dynamics

    Science.gov (United States)

    Wilkman, O.; Herranen, J.; Virtanen, J.; Näränen, J.; Peltoniemi, J.; Gritsevich, M.; Lahtinen, S.; Koivula, H.; Penttilä, A.; Poutanen, M.; Muinonen, K.

    2017-09-01

    We study the possibility of estimating the global scattered radiation flux of the Earth by its radiation-pressure effect on satellite orbits. We perform numerical simulations of typical GNSS orbits, computing various estimates of the magnitude of this effect. We find that changes to orbits caused by reasonable changes in Earth albedo are within detectable limits of modern observational technology, as long as other perturbing forces are modeled well enough.

  20. BALANCE

    Science.gov (United States)

    Carmichael, H.

    1953-01-01

    A torsional-type analytical balance designed to arrive at its equilibrium point more quickly than previous balances is described. In order to prevent external heat sources creating air currents inside the balance casing that would reiard the attainment of equilibrium conditions, a relatively thick casing shaped as an inverted U is placed over the load support arms and the balance beam. This casing is of a metal of good thernnal conductivity characteristics, such as copper or aluminum, in order that heat applied to one portion of the balance is quickly conducted to all other sensitive areas, thus effectively preventing the fornnation of air currents caused by unequal heating of the balance.

  1. Radiation and energy balance of lettuce culture inside a polyethylene greenhouse

    International Nuclear Information System (INIS)

    Frisina, V. de A.; Escobedo, J.F.

    1999-01-01

    The objective of this paper was to describe the radiation and energy balance, during the lettuce (Lactuca sativa, L. cv. Verônica) crop cycle inside a polyethylene greenhouse. The radiation and energy balance was made inside a tunnel greenhouse with polyethylene cover (100 mm) and in an external area, both areas with 35 m 2 . Global, reflected and net radiation, soil heat flux and air temperature (dry and humid) were measured during the crop cycle. A Datalogger, which operated at 1 Hz frequency, storing 5 minutes averages was utilized. The global (K↓) and reflected (K) radiations showed that the average transmission of global radiation (K↓in / K↓ex) was almost constant, near to 79.59%, while the average ratio of reflected radiation (Kin / Kex) was 69.21% with 8.47% standard-deviation. The normalized curves of short-wave net radiation, in relation to the global radiation (K*/ K↓), found for both environments, were almost constant at the beginning of cycle; this relation decreased in the final stage of culture. The normalized relation (Rn/ K↓) was bigger in the external area, about 12%, when the green culture covered the soil surface. The long-wave radiation balance average (L*) was bigger outside, about 50%. The energy balance, estimated in terms of vertical fluxes, showed that, for the external area, in average, 83.07% of total net radiation was converted in latent heat evaporation (LE), and 18% in soil heat flux (G), and 9.96% in sensible heat (H), while inside of the greenhouse, 58.71% of total net radiation was converted in LE, 42.68% in H, and 28.79% in G. (author) [pt

  2. Foraging patch selection in winter: a balance between predation risk and thermoregulation benefit.

    Science.gov (United States)

    Villén-Pérez, Sara; Carrascal, Luis M; Seoane, Javier

    2013-01-01

    In winter, foraging activity is intended to optimize food search while minimizing both thermoregulation costs and predation risk. Here we quantify the relative importance of thermoregulation and predation in foraging patch selection of woodland birds wintering in a Mediterranean montane forest. Specifically, we account for thermoregulation benefits related to temperature, and predation risk associated with both illumination of the feeding patch and distance to the nearest refuge provided by vegetation. We measured the amount of time that 38 marked individual birds belonging to five small passerine species spent foraging at artificial feeders. Feeders were located in forest patches that vary in distance to protective cover and exposure to sun radiation; temperature and illumination were registered locally by data loggers. Our results support the influence of both thermoregulation benefits and predation costs on feeding patch choice. The influence of distance to refuge (negative relationship) was nearly three times higher than that of temperature (positive relationship) in determining total foraging time spent at a patch. Light intensity had a negligible and no significant effect. This pattern was generalizable among species and individuals within species, and highlights the preponderance of latent predation risk over thermoregulation benefits on foraging decisions of birds wintering in temperate Mediterranean forests.

  3. Foraging patch selection in winter: a balance between predation risk and thermoregulation benefit.

    Directory of Open Access Journals (Sweden)

    Sara Villén-Pérez

    Full Text Available In winter, foraging activity is intended to optimize food search while minimizing both thermoregulation costs and predation risk. Here we quantify the relative importance of thermoregulation and predation in foraging patch selection of woodland birds wintering in a Mediterranean montane forest. Specifically, we account for thermoregulation benefits related to temperature, and predation risk associated with both illumination of the feeding patch and distance to the nearest refuge provided by vegetation. We measured the amount of time that 38 marked individual birds belonging to five small passerine species spent foraging at artificial feeders. Feeders were located in forest patches that vary in distance to protective cover and exposure to sun radiation; temperature and illumination were registered locally by data loggers. Our results support the influence of both thermoregulation benefits and predation costs on feeding patch choice. The influence of distance to refuge (negative relationship was nearly three times higher than that of temperature (positive relationship in determining total foraging time spent at a patch. Light intensity had a negligible and no significant effect. This pattern was generalizable among species and individuals within species, and highlights the preponderance of latent predation risk over thermoregulation benefits on foraging decisions of birds wintering in temperate Mediterranean forests.

  4. Communicating the benefits/risks of radiation therapy: maintaining context, perspective, and reassurance.

    Science.gov (United States)

    Marks, Lawrence B

    2011-11-01

    When communicating the benefits and risks of radiation therapy, it is important to provide context, perspective, and reassurance. Radiation is inherently frightening. While this may make discussions about medical radiation's benefits-risks challenging, it also reinforces our responsibility for meaningful and clear discussions with patients, families, colleagues in non-radiation fields, and the public. We need to clearly acknowledge the risks of radiation but also reinforce therapeutic benefits of radiation. For most clinical situations, the benefit-risk ratio is favorable for radiation. Further, we must provide reassurance that we are doing what we can to minimize the risks. This approach helps to build confidence in the radiation team. Obtaining informed consent for patients recently diagnosed with cancer is challenging, since receiving the diagnosis is often extraordinarily stressful. Many patients do not remember or understand verbal discussions at the time of initial consultation. Thus, it is often helpful to provide written information that can be digested by the patient over time. Formal benefit-risk discussions often continue throughout the course of radiation. Further, patients' interactions with all members of the radiation team (e.g., asking questions, understanding the processes) help to augment these formal discussions and build confidence in the entire team-a critical component of informed consent. Since many of the risks of radiation occur months to years post-treatment, discussions with patients need also to consider their prognosis and longevity.

  5. European breast cancer service screening outcomes: a first balance sheet of the benefits and harms.

    Science.gov (United States)

    Paci, Eugenio; Broeders, Mireille; Hofvind, Solveig; Puliti, Donella; Duffy, Stephen William

    2014-07-01

    A recent comprehensive review has been carried out to quantify the benefits and harms of the European population-based mammographic screening programs. Five literature reviews were conducted on the basis of the observational published studies evaluating breast cancer mortality reduction, breast cancer overdiagnosis, and false-positive results. On the basis of the studies reviewed, the authors present a first estimate of the benefit and harm balance sheet. For every 1,000 women screened biennially from ages 50 to 51 years until ages 68 to 69 years and followed up until age 79 years, an estimated seven to nine breast cancer deaths are avoided, four cases are overdiagnosed, 170 women have at least one recall followed by noninvasive assessment with a negative result, and 30 women have at least one recall followed by invasive procedures yielding a negative result. The chance of a breast cancer death being avoided by population-based mammography screening of appropriate quality is more than that of overdiagnosis by screening. These outcomes should be communicated to women offered service screening in Europe. ©2014 American Association for Cancer Research.

  6. Ultrafiltration Therapy for Heart Failure: Balancing Likely Benefits against Possible Risks.

    Science.gov (United States)

    Kazory, Amir

    2016-08-08

    Heart failure remains a major public health concern because of its high prevalence, morbidity, mortality, and financial burden. The poor clinical outcomes associated with acute decompensated heart failure, suboptimal efficacy and safety profile of conventional treatment regimens, and unsatisfactory experiences with the newer classes of pharmacologic therapy underlie the interest in the use of extracorporeal isolated ultrafiltration in this setting. In this article, selected mechanistic aspects of ultrafiltration therapy are briefly reviewed followed by a critical overview of the largest trials in this field. I will discuss the clinical relevance of renal dysfunction and decongestion as two commonly used end points of safety and efficacy in the ultrafiltration trials, with emphasis on the emerging pertinent notions that could challenge our conventional thinking. Finally, a number of practical recommendations (e.g., customization of ultrafiltration rates) are provided for ultrafiltration therapy in the setting of acute decompensated heart failure. Because of a paucity of evidence, universally accepted consensus guidelines cannot yet be generated. As such, when considering ultrafiltration therapy for acute decompensated heart failure, the likely benefits should be carefully balanced against the potential risks for an individual patient. A conceivable implication of the ultrafiltration trials is that collaborative heart failure programs benefiting from nephrology expertise and resources could improve the outcomes and reduce the cost. Copyright © 2016 by the American Society of Nephrology.

  7. Balancing Act: A View of Benefits and Work-Life Balance through the Eyes of Advancement Professionals

    Science.gov (United States)

    Collins, Mary Ellen

    2011-01-01

    People who choose careers in advancement know they're not entering a 9-to-5, 40-hours-a-week profession. Staffers juggle personal lives with their commitment to stressful jobs that involve travel, long hours, weekend events, and deadlines. Work-life balance means different things to different people, but flexibility seems to be a priority for…

  8. A modified Wheeler cap method for radiation efficiency measurement of balanced electrically small antennas

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Pivnenko, Sergey; Breinbjerg, Olav

    2010-01-01

    Measurement of radiation efficiency for ultra small antennas represents a great challenge due to influence of the feeding cable. The Wheeler cap method is often used to measure the radiation efficiency of small antennas. However, it is well applicable for antennas on a ground plane......, but not for balanced antennas like loops or dipoles. In this paper, a modified Wheeler cap method is proposed for the radiation efficiency measurement of balanced electrically small antennas and a three-port network model of the Wheeler cap measurement is introduced. The advantage of the modified method...... is that it is wideband, thus does not require any balun, and both the antenna input impedance and radiation efficiency can be obtained. An electrically small loop antenna and a wideband dipole were simulated and measured according to the proposed method and the results of measurements and simulations are presented...

  9. Communication of benefits and risks of medical radiation: a historical perspective.

    Science.gov (United States)

    Timins, Julie K

    2011-11-01

    X-rays were discovered by Wilhelm Röntgen in 1895. Within one year, benefits of x-rays, such as visualization of fractures, and detriments, such as x-ray dermatitis, were recognized. Nobel Laureates Pierre and Marie Sklodowska Curie discovered the radioactive element radium in 1898, and a year later the application of radiation to cure cancer was reported. A significant price was paid for this: Marie Curie died of aplastic anemia related to her radiation exposure, and her daughter Irene Joliot Curie, Nobelist for radiochemical research, died of radiation-induced leukemia. Internationally developed radiation protection recommendations were formalized starting in the late 1920s. The increasing use of ionizing radiation in medical diagnosis and radiation therapy has brought significant societal benefits. Known risks of therapeutic radiation include coronary artery disease and secondary malignancy. However, recently concerns have been raised of possible very small but incremental increases in malignancies due to diagnostic medical radiation. Patients are largely unaware of, and referring physicians and even radiologists often underestimate, the carcinogenic effects of radiation. There is a need to determine the appropriateness of imaging tests that use ionizing radiation prior to performance; optimize imaging protocols to reduce unnecessary radiation; include patients in the decision process and encourage and enable them to track their radiation exposure; and promote education about medical radiation to patients, referring physicians, radiologists, and members of the public. The basic radiation protection principles of justification, optimization, and application of dose limits still pertain.

  10. Benefits and Risks for People and Livestock of Keeping Companion Animals: Searching for a Healthy Balance.

    Science.gov (United States)

    Sterneberg-van der Maaten, T; Turner, D; Van Tilburg, J; Vaarten, J

    2016-07-01

    The mission of the CALLISTO (Companion Animals multisectoriaL interprofessionaL Interdisciplinary Strategic Think tank On zoonoses) project was to provide an overview of the current situation on the role of companion animals as a source of infectious diseases for people and food animals. It also aimed to identify knowledge and technology gaps for the most important zoonoses and propose targeted actions to reduce the risk of zoonotic diseases transmitted via companion animals. After a 3-year study, its members have developed practical recommendations for improved data collection on companion animal numbers and the mechanisms for disease surveillance in companion animals. They highlight the importance of introducing a system for the unique identification of dogs and other companion animals with an implanted microchip transponder and storage of the details it contains on an internationally accessible online database. Their report also emphasises the need for balanced communication with the public on the risks and benefits of pet ownership and the value of the 'One Health' concept to encourage closer collaboration between veterinary and human medical professionals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Weighing the risks and benefits of cardiac imaging with ionizing radiation.

    Science.gov (United States)

    Gerber, Thomas C; Gibbons, Raymond J

    2010-05-01

    The potential risk of fatal malignancy related to cardiac imaging with ionizing radiation is frequently discussed in the medical literature and in the lay press. Clinicians must weigh this risk against the potential benefits of cardiac imaging, which are typically not considered in these reports about radiation risk. This review summarizes the evidence regarding both the radiation risks and clinical benefits of cardiac imaging to provide guidance to the clinician in specific clinical scenarios. Choosing the right test for the right patient, and performing it with the lowest possible radiation dose, remains a challenge. Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  12. Ultrasound power measurements of HITU transducer with a more stable radiation force balance

    International Nuclear Information System (INIS)

    Karaboece, B; Sadiko'lu, E; Bilgic, E

    2011-01-01

    A new radiation force balance (RFB) system was established at Turkish National Metrology Institute (UME) Ultrasonics Laboratory for High intensity therapeutic ultrasound (HITU) power measurements. The new system is highly stable at high power levels up to 500 Watts. The measurement system consists of a Plexiglas cylindrical balance arm, target mounting scale disks, conical reflecting and absorbing targets, adjustment nuts, and a hanging wire. Both of the two sides of balance were mounted similar size and weight targets. The equilibrium of the balance arm can be adjusted with nuts on screws located at both sides of the balance arm. Transducer was mounted to bottom of water tank. Absorbers in the bottom and the near walls of the tank were used for reflecting target case. Ultrasound power was applied to one scale of the balance where the reflecting/absorbing target was mounted and corresponding force was measured on the other scale of balance where was connected to a balance with a thin wire while the thin rest standing on a support. Ultrasound power of two HITU transducers at frequencies 0.93 MHz, 1.1 MHz and 3.3 MHz were measured with conventional and new system, the values were compared and uncertainty components were assessed in this paper.

  13. Ultrasound power measurements of HITU transducer with a more stable radiation force balance

    Energy Technology Data Exchange (ETDEWEB)

    Karaboece, B; Sadiko' lu, E; Bilgic, E, E-mail: baki.karaboce@ume.tubitak.gov.t [Tuebitak Ulusal Metroloji Enstituesue (UME), P.K. 54 41470 Gebze-Kocaeli (Turkey)

    2011-02-01

    A new radiation force balance (RFB) system was established at Turkish National Metrology Institute (UME) Ultrasonics Laboratory for High intensity therapeutic ultrasound (HITU) power measurements. The new system is highly stable at high power levels up to 500 Watts. The measurement system consists of a Plexiglas cylindrical balance arm, target mounting scale disks, conical reflecting and absorbing targets, adjustment nuts, and a hanging wire. Both of the two sides of balance were mounted similar size and weight targets. The equilibrium of the balance arm can be adjusted with nuts on screws located at both sides of the balance arm. Transducer was mounted to bottom of water tank. Absorbers in the bottom and the near walls of the tank were used for reflecting target case. Ultrasound power was applied to one scale of the balance where the reflecting/absorbing target was mounted and corresponding force was measured on the other scale of balance where was connected to a balance with a thin wire while the thin rest standing on a support. Ultrasound power of two HITU transducers at frequencies 0.93 MHz, 1.1 MHz and 3.3 MHz were measured with conventional and new system, the values were compared and uncertainty components were assessed in this paper.

  14. Dosimetric Benefit of a New Ophthalmic Radiation Plaque

    International Nuclear Information System (INIS)

    Marwaha, Gaurav; Wilkinson, Allan; Bena, James; Macklis, Roger; Singh, Arun D.

    2012-01-01

    Purpose: To determine whether the computed dosimetry of a new ophthalmic plaque, EP917, when compared with the standard Collaborative Ocular Melanoma Study (COMS) plaques, could reduce radiation exposure to vision critical structures of the eye. Methods and Materials: One hundred consecutive patients with uveal melanoma treated with COMS radiation plaques between 2007 and 2010 were included in this study. These treatment plans were generated with the use of Bebig Plaque Simulator treatment-planning software, both for COMS plaques and for EP917 plaques using I-125. Dose distributions were calculated for a prescription of 85 Gy to the tumor apex. Doses to the optic disc, opposite retina, lens, and macula were obtained, and differences between the 2 groups were analyzed by standard parametric methods. Results: When compared with the COMS plaques, the EP917 plaques used fewer radiation seeds by an average difference of 1.94 (P<.001; 95% confidence interval [CI], −2.8 to −1.06) and required less total strength of radiation sources by an average of 17.74 U (air kerma units) (P<.001; 95% CI, −20.16 to −15.32). The total radiation doses delivered to the optic disc, opposite retina, and macula were significantly less by 4.57 Gy, 0.50 Gy, and 11.18 Gy, respectively, with the EP917 plaques vs the COMS plaques. Conclusion: EP917 plaques deliver less overall radiation exposure to critical vision structures than COMS treatment plaques while still delivering the same total therapeutic dose to the tumor.

  15. Dosimetric Benefit of a New Ophthalmic Radiation Plaque

    Energy Technology Data Exchange (ETDEWEB)

    Marwaha, Gaurav, E-mail: marwahg2@ccf.org [Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Cleveland Clinic Foundation, Cleveland, Ohio (United States); Wilkinson, Allan [Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Cleveland Clinic Foundation, Cleveland, Ohio (United States); Bena, James [Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Cleveland Clinic Foundation, Cleveland, Ohio (United States); Macklis, Roger [Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Cleveland Clinic Foundation, Cleveland, Ohio (United States); Singh, Arun D. [Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio (United States); Cleveland Clinic Foundation, Cleveland, Ohio (United States)

    2012-12-01

    Purpose: To determine whether the computed dosimetry of a new ophthalmic plaque, EP917, when compared with the standard Collaborative Ocular Melanoma Study (COMS) plaques, could reduce radiation exposure to vision critical structures of the eye. Methods and Materials: One hundred consecutive patients with uveal melanoma treated with COMS radiation plaques between 2007 and 2010 were included in this study. These treatment plans were generated with the use of Bebig Plaque Simulator treatment-planning software, both for COMS plaques and for EP917 plaques using I-125. Dose distributions were calculated for a prescription of 85 Gy to the tumor apex. Doses to the optic disc, opposite retina, lens, and macula were obtained, and differences between the 2 groups were analyzed by standard parametric methods. Results: When compared with the COMS plaques, the EP917 plaques used fewer radiation seeds by an average difference of 1.94 (P<.001; 95% confidence interval [CI], -2.8 to -1.06) and required less total strength of radiation sources by an average of 17.74 U (air kerma units) (P<.001; 95% CI, -20.16 to -15.32). The total radiation doses delivered to the optic disc, opposite retina, and macula were significantly less by 4.57 Gy, 0.50 Gy, and 11.18 Gy, respectively, with the EP917 plaques vs the COMS plaques. Conclusion: EP917 plaques deliver less overall radiation exposure to critical vision structures than COMS treatment plaques while still delivering the same total therapeutic dose to the tumor.

  16. Benefits afforded by combined temozolomide, radiation and stem ...

    African Journals Online (AJOL)

    Purpose: To compare the efficacy of temozolomide, radiation and stem cell therapy in glioma management. Methods: A total of 112 patients with glioblastoma were divided into four groups, each of 28 patients. Group I received daily temozolomide at 150 mg/m2; Group II radiotherapy of 30.0 Gy; Group III mesenchymal stem ...

  17. Cost-Benefit Analysis of Radiation Therapy Services at Tripler Army Medical Center

    National Research Council Canada - National Science Library

    Diehl, Diane S

    2004-01-01

    The purpose of this analysis was to examine the costs and benefits associated with continuance of "in-house" radiation therapy services to eligible beneficiaries at Tripler Army Medical Center (TAMC...

  18. An economic benefit analysis on the cobalt-60 irradiation facility of Beijing Radiation Research Center

    International Nuclear Information System (INIS)

    Wang Binlin

    1995-01-01

    The peculiarity, the investment and annual operating cost of the 3.7 x 10 16 Bq (MCi) cobalt-60 irradiation facility at Beijing Radiation Application Research Centre are described. Its economic benefits each year are analyzed according to several year operating practice. Some related questions on carrying out radiation processing are raised and discussed. (author)

  19. Radiation techniques in crop and plant breeding. Multiplying the benefits

    International Nuclear Information System (INIS)

    Ahloowalia, B.S.

    1998-01-01

    World food production is based on growing a wide variety of fruits, vegetables, and crops developed through advances in science. Plant breeders have produced multiple varieties that grow well in various types of soils and under diverse climates in different regions of the world. Conventionally, this is done by sexual hybridization. This involves transferring pollen from one parent plant to another to obtain hybrids. The subsequent generations of these hybrids are grown to select plants which combine the desired characters of the parents. However, another method exists by which the genetic make-up of a given plant variety can be changed without crossing with another variety. With this method, a variety retains all its original attributes but is upgraded in one or two changed characteristics. This method is based on radiation-induced genetic changes, and its referred to as ''induced mutations''. During the past thirty years, more than 1800 mutant varieties of plants have been released, many, of which were induced with radiation. Plant tissue and cell culture (also called in vitro culture) in combination with radiation is a powerful technique to induce mutations, particularly for the improvement of vegetatively propagated crops. These crops include cassava, garlic, potato, sweet potato, yams, sugarcane, ornamentals such as chrysanthemum, carnation, roses, tulips, daffodil, and many fruits (e.g. apple, banana, plantain, citrus, date palm, grape, papaya, passion fruit, and kiwi fruit). In some of these plants, either there is no seed set (e.g. banana) or the seed progeny produces plants which do not have the right combination of the desired characteristics. These techniques are also useful in the improvement of forest trees having a long lifespan before they produce fruit and seed. This article briefly reviews advances in plant breeding techniques, with a view towards improving the transfer of technologies to more countries

  20. [Balancing risks and benefits of mammography screening for breast cancer: would you support its recommendation in Peruvian women?].

    Science.gov (United States)

    Posso, Margarita; Puig, Teresa; Bonfill, Xavier

    2015-01-01

    The aim of this study is to assess the balance between benefits and risks of population-based mammography screening programs in Peruvian women. We followed the criteria proposed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group. A generic search strategy for published studies was performed using Medline and other sources of national data (gray literature). The evidence of benefits, risks, costs and preferences of the population was used in order to state a recommendation in favour, or against, screening. We found five systematic reviews (SR) that evaluated the balance between benefit and risks, two economic evaluations based on Peruvian data, and one study that reported the preferences of Peruvian women. The quality of evidence of the SR was moderate in favour of screening in women aged 50-69 years. The balance of risks and benefits showed a higher probability of overdiagnosis compared with the reduction in mortality. The most cost-effective strategy was the triennial mammography. Perceived barriers could seriously compromise the participation of women. In conclusion, the recommendation of mammography screening for Peruvian women is weak, even more if we take into account other health necessities of the population. However, if implemented, triennial mammography in women aged 50-69 years could be the more suitable screening strategy.

  1. Communication of radiation benefits and risks in decision making: some lessons learned.

    Science.gov (United States)

    Locke, Paul A

    2011-11-01

    This paper is focused on summarizing the "lessons learned" from discussions at the 2010 NCRP Annual Meeting on effective communications on the subject of radiation benefits and risks in public exposures. Five main lessons learned are discussed in regard to effective methods of public communication: the use of new social media communication tools such as Facebook and Twitter, emergency situations that require rapid societal and personal messaging, medical radiological procedures where benefits must be described in comparison to long-term health risks of radiation exposures, and information that should be provided to stakeholders in situations such as environmental radionuclide contamination to which members of the public may be exposed. It is concluded that effective communications in which radiation benefits are contrasted with health risks of exposure are an important aspect of making and implementing decisions on employing radiation health protection procedures.

  2. Ethical trials to determine the risks and benefits of radiation exposure from coronary CT angiography.

    Science.gov (United States)

    Haramati, Linda B

    2008-10-01

    This essay discusses the ethical implications of medical research using ionizing radiation in the diagnostic imaging range. Coronary CT angiography will be used as an example. Since coronary artery disease is the most common cause of death in the United States, any change in the work-up or management of patients with coronary artery disease has enormous clinical and economic implications. Risks of diagnostic radiation differ from those encountered in routine medical research as radiation-related cancers and heritable genetic damage can manifest in the irradiated individual or in subsequent generations. The risk to research subjects is ethically troubling because the research may not offer direct benefit to participants, although the benefits to society and future patients could be considerable. The American College of Radiology has a mandate to lead in the discussion of how to best minimize the risks of diagnostic radiation exposure in clinical research while encouraging studies likely to maximize benefits for future patients.

  3. Influence of snow cover changes on surface radiation and heat balance based on the WRF model

    Science.gov (United States)

    Yu, Lingxue; Liu, Tingxiang; Bu, Kun; Yang, Jiuchun; Chang, Liping; Zhang, Shuwen

    2017-10-01

    The snow cover extent in mid-high latitude areas of the Northern Hemisphere has significantly declined corresponding to the global warming, especially since the 1970s. Snow-climate feedbacks play a critical role in regulating the global radiation balance and influencing surface heat flux exchange. However, the degree to which snow cover changes affect the radiation budget and energy balance on a regional scale and the difference between snow-climate and land use/cover change (LUCC)-climate feedbacks have been rarely studied. In this paper, we selected Heilongjiang Basin, where the snow cover has changed obviously, as our study area and used the WRF model to simulate the influences of snow cover changes on the surface radiation budget and heat balance. In the scenario simulation, the localized surface parameter data improved the accuracy by 10 % compared with the control group. The spatial and temporal analysis of the surface variables showed that the net surface radiation, sensible heat flux, Bowen ratio, temperature and percentage of snow cover were negatively correlated and that the ground heat flux and latent heat flux were positively correlated with the percentage of snow cover. The spatial analysis also showed that a significant relationship existed between the surface variables and land cover types, which was not obviously as that for snow cover changes. Finally, six typical study areas were selected to quantitatively analyse the influence of land cover types beneath the snow cover on heat absorption and transfer, which showed that when the land was snow covered, the conversion of forest to farmland can dramatically influence the net radiation and other surface variables, whereas the snow-free land showed significantly reduced influence. Furthermore, compared with typical land cover changes, e.g., the conversion of forest into farmland, the influence of snow cover changes on net radiation and sensible heat flux were 60 % higher than that of land cover changes

  4. Toward a holistic approach in the presentation of benefits and risks of medical radiation.

    Science.gov (United States)

    Wagner, Louis K

    2011-11-01

    Frequently messages are conveyed about benefit and risk in medical imaging or in imaging-guided medical intervention that are quite different from the intended communication. This is because communication is not merely the words used to express an idea. The message involves many personal factors on the part of the communicator and on the part of the audience. The intent of this article is to disclose some of the underlying factors that disproportionately bias communication of benefit and risk. Suggestions on how to develop a holistic communication of benefits and risks are presented. It is recommended that communication about the application of radiation to patients be disassociated from standard radiation protection concepts. The medical profession should develop unique communication tools to deliver a message that focuses on benefit/risk as a holistic entity, not benefit or risk as separate entities.

  5. Multidisciplinary approaches to radiation-balanced lasers (MARBLE): a MURI program by AFOSR (Conference Presentation)

    Science.gov (United States)

    Sheik-Bahae, Mansoor

    2017-02-01

    An overview of the diverse research activities under the newly funded MURI project by AFOSR will be presented. The main goal is to advance the science of radiation-balanced lasers, also known as athermal lasers, in order to mitigate the thermal degradation of the high-power laser beams. The MARBLE project involves researchers from four universities and spans research activities in rare-earth doped crystals and fibers to semiconductor disc lasers.

  6. Balancing the benefits and risks of low-dose glucocorticoid in rheumatoid arthritis.

    Directory of Open Access Journals (Sweden)

    Tânia Santiago

    2015-01-01

    -dose GCs in RA. This contention cannot be resolved without a clear understanding of the potential risks of adverse effects of these drugs. Unfortunately, currently available evidence is limited, but the need to optimize benefit-risk ratio of GCs represents a continuous challenge to the practicing clinician. This review reinforces the need for balancing risks and benefits of GCs use in RA, with a focus on chronic oral therapy. First, we address the rapid effect of GCs on disease activity and their long-term effects on radiographic damage, followed by their prolonged use in controlled disease. Next, we discuss the toxicity of low-dose GC therapy. Finally, we describe strategies and recommendations for its safe use and new therapeutic approaches, including chronotherapy, which may improve our ability to tailor treatment to the individual patient’s needs. A. Benefits Symptomatic benefit In active RA, prednisone is frequently added for a short period to the treatment regimen to rapidly minimize disease activity while awaiting a clinical response to a slower-acting disease-modifying antirheumatic drugs (DMARD. A review (3 provided evidence of short-term benefit in RA: a dose below prednisolone 15 mg/day is more effective than either placebo or a nonsteroidal anti-inflammatory drugs (NSAID, with a large effect size of 1.75 on pain. In 2000, a Cochrane meta-analysis (4 including 7 studies (253 patients in total evaluating the symptomatic effect of GCs treatment in RA, concluded that prednisone (or a comparable GC preparation at a mean dosage of less than or equal to 15 mg/day for a period of 6 months, was significantly more effective than placebo controls, with an effect size for pain of 0.43. Significant improvement was also documented in other outcomes measures: standardized mean difference for tender joints = -0.37 (95%CI: -0. 59 to -0.14, swollen joints = -0.41 (-0.67 to -0.16 and functional status = -0.57 (-0.92 to -0.22. Another meta-analysis of short-term (median length

  7. [Benefits of breathing-adapted radiation therapy for breast cancer].

    Science.gov (United States)

    Vourch, S; Miglierini, P; Miranda, O; Malhaire, J-P; Boussion, N; Pradier, O; Schick, U

    2016-02-01

    The purpose of this study was to compare free-breathing radiotherapy, end-expiration gating and end-inspiration gating for left breast cancer, with respect to the target volume coverage and dose to organs at risk. Sixteen patients underwent 3D and 4D simulation CT. For each patient, five dosimetric plans were compared: free breathing, end-inspiration gating, end-expiration gating, and two optimised plans with a 3mm reduction of the posterior field edge to create optimised end-inspiration and end-expiration plans. Dose-volume parameters, including planning target volume coverage and dose to lung, heart and left anterior descending coronary artery were analysed. Planning target volume coverage was adequate and similar in the five dosimetric plans (P=0.49). Significant advantage was found for end-inspiration gating in sparing the ipsilateral lung, heart and left anterior descending coronary artery compared to free-breathing 3D radiotherapy. Optimised end-inspiration was even more favourable than end-inspiration gating (Pradiation therapy allowed for dose reduction to organs at risk (left lung, heart and left anterior descending coronary artery), while keeping the same planning target volume coverage. Therefore it can be considered as an interesting option for left breast cancer radiation treatment. Copyright © 2015 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  8. Balancing accuracy, efficiency, and flexibility in a radiative transfer parameterization for dynamical models

    Science.gov (United States)

    Pincus, R.; Mlawer, E. J.

    2017-12-01

    Radiation is key process in numerical models of the atmosphere. The problem is well-understood and the parameterization of radiation has seen relatively few conceptual advances in the past 15 years. It is nonthelss often the single most expensive component of all physical parameterizations despite being computed less frequently than other terms. This combination of cost and maturity suggests value in a single radiation parameterization that could be shared across models; devoting effort to a single parameterization might allow for fine tuning for efficiency. The challenge lies in the coupling of this parameterization to many disparate representations of clouds and aerosols. This talk will describe RRTMGP, a new radiation parameterization that seeks to balance efficiency and flexibility. This balance is struck by isolating computational tasks in "kernels" that expose as much fine-grained parallelism as possible. These have simple interfaces and are interoperable across programming languages so that they might be repalced by alternative implementations in domain-specific langauges. Coupling to the host model makes use of object-oriented features of Fortran 2003, minimizing branching within the kernels and the amount of data that must be transferred. We will show accuracy and efficiency results for a globally-representative set of atmospheric profiles using a relatively high-resolution spectral discretization.

  9. The long-term benefits of a multi-component exercise intervention to balance and mobility in healthy older adults.

    Science.gov (United States)

    Bird, M; Hill, K D; Ball, M; Hetherington, S; Williams, A D

    2011-01-01

    We examined the long-term effects of a multi-component exercise program on balance, mobility and exercise behavior. The benefits of a community-based resistance and flexibility exercise intervention in a group of healthy older (60-75 years) individuals were recorded 12 months after completion of the randomized control intervention. Differences between those participants who continued to exercise and those who discontinued were investigated. Significant improvements from baseline in sit to stand (pexercise intervention group, with a control group unchanged. Participants who continued exercising had significantly greater improvements in strength immediately after the intervention, compared to those who discontinued (p=0.004). Those who continued regular resistance training performed better in the step test at 12-month follow up (p=0.009) and believed that the program was of more benefit to their physical activity (pexercising. Benefits to balance and mobility persist 1 year after participation in a multi-component exercise program, due in part to some continuing participation in resistance training. Motivation to continue resistance training may be related real and perceived benefits attained from the intervention as well as the environmental context of the intervention. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  10. Balancing benefits and costs of autmated task allocation in mobile surveillance

    NARCIS (Netherlands)

    Streefkerk, J.W.; Esch-Bussemakers, M. van; Neerincx, M.

    2010-01-01

    Motivation - Automated task allocation systems are prone to errors (e.g. incorrect advice) due to context events. Empirical assessment is needed of how the costs of incorrect task allocation advice relate to the benefits. Research approach - Claims regarding benefits and costs are tested in a team

  11. Subtitles in the classroom: Balancing the benefits of dual coding with ...

    African Journals Online (AJOL)

    Using the correct presentation speed of subtitles in multisource information in an educational setting is imperative for the activation of the potential benefits of multisource communication (that includes subtitles) for learning. The findings of the study stand to benefit all fields of multimedia educational design, but also have ...

  12. 76 FR 67105 - Cash Balance Plans; Benefit Determinations and Plan Valuations for Statutory Hybrid Plans...

    Science.gov (United States)

    2011-10-31

    ... minimis lump sum would nevertheless be required to be valued, for purposes of part 4044, in the form of a... margin. Many plans using variable rates adopted the standard indices and associated margins set forth in.... PBGC pays benefits in a single installment if the lump sum value of a benefit payable by PBGC is de...

  13. International RADAGAST Experiment in Niamey, Niger: Changes and Drivers of Atmospheric Radiation Balance

    Energy Technology Data Exchange (ETDEWEB)

    Kassianov, Evgueni I.; McFarlane, Sally A.; Barnard, James C.; Flynn, Connor J.; Slingo, A.; Bharmal, N.; Robinson, G. J.; Turner, David D.; Miller, Mark; Ackerman, Thomas P.; Miller, R.

    2009-03-11

    The Sahara desert is notorious as a source of massive dust storms. This dust dramatically influences the Earth-atmosphere energy budget through reflecting and absorbing the incoming sunlight. However, this budget is poorly understood, and in particular, we lack quantitative understanding of how the diurnal and seasonal variation of meteorological variables and aerosol properties influence the propagation of solar irradiance through the desert atmosphere. To improve our understanding of these influences, coincident and collocated observations of fluxes, measured from both space and the surface, are highly desirable. Recently, the unique capabilities of the African Monsoon Multidisciplinary Analysis (AMMA) Experiment, the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF), the Geostationary Earth Radiation Budget (GERB) instrument, and the Spinning Enhanced Visible and Infrared Imager (SEVIRI) were combined effectively as part of a large international project: the Radiative Atmospheric Divergence using AMF, GERB data and AMMA Stations (RADAGAST), which took place in Niamey, Niger, in 2006. The RADAGAST objectives, instrumentation, and scientific background are presented in [1]. Initial results from RADAGAST documented the strong radiative impact of a major Saharan dust storm on the Earth’s radiation budget [2]. A special issue of the Journal of Geophysical Research will include a collection of papers with the more complete results from RADAGAST (e.g., [1,3], and references therein). In particular, a year-long time series from RADAGAST are used to investigate (i) the factors that control the radiative fluxes and the divergence of radiation across the atmosphere [3-5], (ii) seasonal changes in the surface energy balance and associated variations in atmospheric constituents (water vapor, clouds, aerosols) [6], and (iii) sensitivity of microphysical, chemical and optical properties of aerosols to their sources and the atmospheric conditions [7]. Here we show

  14. The Impact of Balanced Risk-Benefit Information and Initial Attitudes on Post-Information Attitudes

    NARCIS (Netherlands)

    Dijk, van H.; Fischer, A.R.H.; Jonge, de J.; Rowe, G.; Frewer, L.J.

    2012-01-01

    In a realistic social context, people are confronted with both positive and negative information, yet research on this topic is relatively scarce. We present 2 studies examining the role of initial attitudes on the impact of one-sided vs. balanced positive and negative information on attitudes

  15. Do we need a new cost/benefit assessment for low radiation doses?

    International Nuclear Information System (INIS)

    Becker, K.

    1997-01-01

    Current cost/benefit estimates related to radiation protection, e.g. regarding the consequences of population exposures after accidents, decommissioning and waste management programs, etc., are based on the linear-no-threshold hypothesis and the related collective dose concept, as recommended in ICRP 60, the Basic Safety Standards (BSS), and EU directives. However, the extrapolation from very high to very low doses is increasingly questioned by radiation scientists for fundamental radiobiological reasons, as well as by epidemiological studies with exposed populations. Moreover, if also applied to natural radiation (e.g. in mining or high natural radiation areas, or radon in buildings), the resulting high costs justify, for ethical as well as socio-economical reasons, a careful analysis of the actual benefits of such measures, to be compared with demonstrable health detriments and the cost/benefit ratio in other public health and risk reduction programs in modern industrial societies. Some aspects of these problems will be discussed briefly, and summarized in questions addressed to the advisory bodies on whose recommendations current regulations are based. As a first step, abolishment of the use of the collective dose concept below about 100 mSv total of ''artificial'' radiation per person of the public, and below 50 mSv p.a. for radiation workers, appears advisable. (author)

  16. Energy and carbon balances in cheatgrass, an essay in autecology. [Shortwave radiation, radiowave radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hinds, W.T.

    1975-01-01

    An experiment to determine the fates of energy and carbon in cheatgrass (Bromus tectorum L.) was carried out on steep (40/sup 0/) north- and south-facing slopes on a small earth mound, using many small lysimeters to emulate swards of cheatgrass. Meteorological conditions and energy fluxes that were measured included air and soil temperatures, relative humidity, wind speed, incoming shortwave radiation, net all-wave radiation, heat flux to the soil, and evaporation and transpiration separately. The fate of photosynthetically fixed carbon during spring growth was determined by analysis of the plant tissues into mineral nutrients, crude protein, crude fat, crude fiber, and nitrogen-free extract (NFE) for roots, shoots, and seeds separately. (auth)

  17. Analysis of the clinical benefit of 5-fluorouracil and radiation treatment in locally advanced pancreatic cancer

    International Nuclear Information System (INIS)

    Fisher, Barbara J.; Perera, Francisco E.; Kocha, Walter; Tomiak, Anna; Taylor, Marianne; Vincent, Mark; Bauman, Glenn S.

    1999-01-01

    Purpose: To assess the palliative benefit of 5-fluorouracil (5-FU) and radiotherapy in patients with surgically unresectable localized pancreatic cancer. Methods and Materials: Twenty-five patients with locally advanced surgically unresectable symptomatic pancreatic cancer received 5-FU chemotherapy and local radiation therapy. They were retrospectively reviewed in regard to their clinical benefit response (a composite of measurement of pain assessment, weight, and Karnofsky performance status [KPS]), as well as radiological response, time to progression, and overall survival. Results: Median survival for the 25 patients was 9 months and median progression-free survival was 6 months. Thirty-two percent of patients survived in excess of 1 year. Analgesic requirements increased >50% in 2 patients and KPS deteriorated in 10 patients. Of the 13 remaining patients, 2 sustained a >7% weight loss and 2 gained weight post-treatment. Six patients improved in one parameter of analgesic consumption, weight loss or KPS without deteriorating in any others. Thus, the clinical benefit response index for 5-FU-radiation was 6/25 (24%). In terms of tumor response, 8 patients (44%) demonstrated a reduction in tumor volume post-treatment, 4 of whom (22%) experienced a >50% reduction. Four additional patients had radiologically stable disease. Conclusion: In this retrospective analysis, the clinical benefit response index for 5-FU-radiation was 24%, a value similar to the 23.8% reported for single agent gemcitabine. The median survival of 7 months was also similar to the 5.65 months reported for gemcitabine. The radiological partial response rate of 22% and the 1-year survival of 32% were higher for 5-FU-radiation than the reported values for gemcitabine. A randomized trial would be necessary to compare 5-FU-radiation to gemcitabine directly; however, from this review it did not appear that the overall palliative benefit of 5-FU-radiation was inferior to gemcitabine

  18. Seasonal changes in the radiation balance of subarctic forest and tundra

    International Nuclear Information System (INIS)

    Lafleur, P.M.; Renzetti, A.V.; Bello, R.

    1993-01-01

    This paper examines the seasonal behavior of the components of the radiation budget of subarctic tundra and open forest near Churchill, Manitoba. Data were collected between late February and August 1990. The presence of the winter snowpack is the most important factor which affects the difference in radiation balances of tundra and forest. Overall, net radiation was about four to five times larger over the forest when snow covered the ground. Albedo differences were primarily responsible for this difference in net radiation; however, somewhat smaller net longwave losses were experienced at the tundra site. The step decrease in albedo from winter to summer (i.e. snow-covered to snow-free conditions) was significant at both sites. The forest albedo decreased by about three-fold while the tundra experienced a seven-fold decrease. Net radiation at both sites increased in direct response to the albedo change. Transmissivity of the atmosphere near Churchill also appeared to change at about the same time as the loss of the snow cover and may be related to changing air masses which bring about the final snow melt

  19. Cost-benefit analysis of establishing and operating radiation oncology services in Fiji.

    Science.gov (United States)

    Kim, Eunkyoung; Cho, Yoon-Min; Kwon, Soonman; Park, Kunhee

    2017-10-01

    Rising demand for services of cancer patients has been recognised by the Government of Fiji as a national health priority. Increasing attention has been paid to the lack of service of radiation therapy or radiotherapy in Fiji. This study aims to estimate and compare the costs and benefits of introducing radiation oncology services in Fiji from the societal perspective. Time horizon for cost-benefit analysis (CBA) was 15 years from 2021 to 2035. The benefits and costs were converted to the present values of 2016. Estimates for the CBA model were taken from previous studies and expert opinions and data obtained from field visits to Fiji in January 2016. Sensitivity analyses with changing assumptions were undertaken. The estimated net benefit, applying the national minimum wage (NMW) to measure monetary value for life-year gained, was -31,624,421 FJD with 0.69 of benefit-cost (B/C) ratio. If gross national income (GNI) per capita was used for the value of life years, net benefit was 3,975,684 FJD (B/C ratio: 1.04). With a pessimistic scenario, establishing the center appeared to be not cost-beneficial, and the net benefit was -53,634,682 FJD (B/C ratio: 0.46); net benefit with an optimistic scenario was estimated 23,178,189 FJD (B/C ratio: 1.20). Based on the CBA results from using GNI per capita instead of the NMW, this project would be cost-beneficial. Introducing a radiation oncology center in Fiji would have potential impacts on financial sustainability, financial protection, and accessibility and equity of the health system. Copyright © 2017 World Health Organization. Published by Elsevier Ltd.. All rights reserved.

  20. Radiation balance at the surface in the city of São Paulo, Brazil: diurnal and seasonal variations

    NARCIS (Netherlands)

    Ferreira, M.J.; Oliveira, de A.P.; Soares, J.; Codato, G.; Wilde Barbaro, E.; Escobedo, J.F.

    2012-01-01

    The main goal of this work is to describe the diurnal and seasonal variations of the radiation balance components at the surface in the city of São Paulo based on observations carried out during 2004. Monthly average hourly values indicate that the amplitudes of the diurnal cycles of net radiation

  1. Task and error analysis balancing benefits over business of electronic medical records.

    Science.gov (United States)

    Carstens, Deborah Sater; Rodriguez, Walter; Wood, Michael B

    2014-01-01

    Task and error analysis research was performed to identify: a) the process for healthcare organisations in managing healthcare for patients with mental illness or substance abuse; b) how the process can be enhanced and; c) if electronic medical records (EMRs) have a role in this process from a business and safety perspective. The research question is if EMRs have a role in enhancing the healthcare for patients with mental illness or substance abuse. A discussion on the business of EMRs is addressed to understand the balancing act between the safety and business aspects of an EMR.

  2. Big Data in Education: Balancing the Benefits of Educational Research and Student Privacy. A Workshop Summary

    Science.gov (United States)

    National Academy of Education, 2017

    2017-01-01

    This is a critical time to understand the benefits and risks of educational research using large data sets. Massive quantities of educational data can now be stored, analyzed, and shared. State longitudinal data systems can track individual students from pre-K through college and work. Districts and schools keep detailed data on individual…

  3. Influences of deforestation on radiation and heat balances in tropical peat swamp forest in Thailand

    International Nuclear Information System (INIS)

    Suzuki, S.; Ishida, T.; Nagano, T.; Matsukawa, S.

    1997-01-01

    The difference of radiation and heat balances between a natural peat swamp forest and a deforested secondary forest has been investigated in Narathiwat Province, Thailand. Micrometeorological measurements were conducted continuously on observation towers 38 m and 4 m in heights in the primary forest and the secondary forest respectively. Results show that the deforestation of peat swamp forest leads to an increase in the sensible heat flux in the secondary forest. The yearly average ratio of the sensible heat flux to the net radiation was 20.9% in the peat swamp forest, and 33.2% in the secondary forest from Aug. 1995 to Jul. 1996. A ratio more than 40% was observed only in the dry season in the secondary forest. The change in sensible heat flux seemed to be influenced by the change in ground water levels. (author)

  4. Use of MODIS Images to Quantify the Radiation and Energy Balances in the Brazilian Pantanal

    Directory of Open Access Journals (Sweden)

    Antônio H. de C. Teixeira

    2015-11-01

    Full Text Available MODIS images during the year 2012 were used for modelling of the radiation and energy balance components with the application of the SAFER algorithm (Simple Algorithm for Evapotranspiration Retrieving in the Brazilian Pantanal area. Pixels from the main sub-regions of Barão de Melgaço (BR, Paiaguás (PA and Nhecolândia (NH were extracted in order to process microclimatic comparisons. In general, the net radiation (Rn relied much more on the global solar radiation (RG levels than on water conditions and ecosystem types, in accordance with the low Rn standard deviation values. The fraction of the available energy used as latent heat flux (λE were, on average, 65, 50 and 49% for the BR, PA and NH sub-regions, respectively. Horizontal heat advection, identified by the negative values of sensible heat flux (H, made several pixels with λE values higher than those for Rn in the middle of the year. Taking the evaporative fraction (Ef as a surface moisture indicator, the Tree-Lined Savanna (TLS was considered the moister ecosystem class, with 58% of the available energy being used as λE, while the driest one was the modified ecosystem Anthropogenic Changes (AC, presenting a λE/Rn fraction of 0.46. According to the spatial and temporal consistencies, and after comparisons with other previous point and large-scale studies, the SAFER algorithm proved to have sensibility to quantify and compare the large-scale radiation and energy balance components in the different ecosystems of the Brazilian Pantanal. The algorithm is useful for monitoring the energy exchange dynamics among the different terrestrial and aquatic ecosystem types throughout the seasons of the year.

  5. Effects of individual and group exercise programs on pain, balance, mobility and perceived benefits in rheumatoid arthritis with pain and foot deformities

    OpenAIRE

    do Carmo, Carolina Mendes; Almeida da Rocha, Bruna; Tanaka, Clarice

    2017-01-01

    [Purpose] To verify the effects of individual and group exercise programs on pain, balance, mobility and perceived benefits of rheumatoid arthritis patients (RA) with pain and foot deformities. [Subjects and Methods] Thirty patients with RA pain and foot deformity were allocated into two groups: G1: individual exercise program and G2: group exercise program. The variables analyzed were Numerical Rating Scale (NRS) for pain, Berg Balance Scale (BBS) for balance, Timed Up & Go Test (TUG) and Fu...

  6. Exercise in children with common congenital heart lesions: balancing benefits with risks.

    Science.gov (United States)

    Halliday, Melanie; Selvadurai, Hiran; Sherwood, Megan; Fitzgerald, Dominic A

    2013-10-01

    Children with corrected common congenital heart lesions are often withheld from regular exercise by their parents. While there are some modest risks with exercise, they should be seen in perspective, and the life-long benefits of regular exercise on general health, mood and well-being should be emphasised. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  7. EDITORIAL: The Earth radiation balance as driver of the global hydrological cycle

    Science.gov (United States)

    Wild, Martin; Liepert, Beate

    2010-06-01

    Variations in the intensity of the global hydrological cycle can have far-reaching effects on living conditions on our planet. While climate change discussions often revolve around possible consequences of future temperature changes, the adaptation to changes in the hydrological cycle may pose a bigger challenge to societies and ecosystems. Floods and droughts are already today amongst the most damaging natural hazards, with floods being globally the most significant disaster type in terms of loss of human life (Jonkman 2005). From an economic perspective, changes in the hydrological cycle can impose great pressures and damages on a variety of industrial sectors, such as water management, urban planning, agricultural production and tourism. Despite their obvious environmental and societal importance, our understanding of the causes and magnitude of the variations of the hydrological cycle is still unsatisfactory (e.g., Ramanathan et al 2001, Ohmura and Wild 2002, Allen and Ingram 2002, Allan 2007, Wild et al 2008, Liepert and Previdi 2009). The link between radiation balance and hydrological cycle Globally, precipitation can be approximated by surface evaporation, since the variability of the atmospheric moisture storage is negligible. This is the case because the fluxes are an order of magnitude larger than the atmospheric storage (423 x 1012 m3 year-1 versus 13 x 1012 m3 according to Baumgartner and Reichel (1975)), the latter being determined by temperature (Clausius-Clapeyron). Hence the residence time of evaporated water in the atmosphere is not more than a few days, before it condenses and falls back to Earth in the form of precipitation. Any change in the globally averaged surface evaporation therefore implies an equivalent change in precipitation, and thus in the intensity of the global hydrological cycle. The process of evaporation requires energy, which it obtains from the surface radiation balance (also known as surface net radiation), composed of the

  8. Use of work-life balance benefits guaranteed by law in Poland - Do size of the enterprise and gender matter?

    Science.gov (United States)

    Merecz-Kot, Dorota; Drabek, Marcin; Stańczak, Aleksander; Andysz, Aleksandra; Jacukowicz, Aleksandra

    2017-07-26

    The paper is aimed at indicating the similarities and differences in use of benefits supporting work-life balance (WLB) between women and men working in Polish small/medium and large enterprises. The sample included 556 workers (311 women, 245 men), aged 20-68 years old employed on the basis of employment contracts for at least a year in Polish enterprises. The respondents completed a questionnaire on the use of benefits guaranteed by the Polish Labour Code, referring to their current workplaces. Women took maternity leaves and returned to the same work position after using childcare leaves more often than men. Men took leaves on demand more often than women. Our results also showed that in comparison to women working in smaller enterprises, those working in large enterprises were more likely to use almost all the analyzed WLB benefits - paid days off to take care of others, educational leaves, leaves on demand, maternity leaves and return to the same work position after childcare leave, reduction of business trips when pregnant or having young children and breastfeeding breaks. The size of enterprise, however, did not differentiate the take-up of benefits among the studied men. Our analysis brought unexpected results on the lack of common availability of the WLB benefits guaranteed by the law in the case of employees who worked on the basis of employment contracts. We also found that women used most of child rearing benefits guaranteed by the law more often than men, which might reflect still a traditional division of child care responsibilities in Poland. Med Pr 2017;68(5):575-581. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  9. A study on cost-benefit analysis and development of numerical guideline for the radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chang Sun; Song, Jae Hyuk; Son, Ki Yoon; Park, Moon Soo; Kim, Chong Uk [Seoul National Univ., Seoul (Korea, Republic of)

    1998-06-15

    By ALARA, radiation protection should be achieved so that radiation exposure should be kept in reasonably low level considering the economical and social factors of the society. But it is difficult to apply this principle practically due to the qualitative properties of the factors and the ambiguity of the principle itself. To resolve the problems, the decision aiding techniques are needed which can quantify the factors used in decision making. These factors include the effects of radiation on body and economical and social factors. The cost-benefit analysis is the most representative decision aiding technique. The scopes and contents of the first period of this study are as follows: the merits and demerits of several methods of cost-benefit analysis are investigated and the improvement is provided, the cost data of the radioactive waste systems are derived which can be used in practical cost-benefit analysis, the decision making method is established on the basis of ALARA procedures, safety regulatory guides for cost-benefit analysis are provided.

  10. Use of benefit-cost analysis in establishing Federal radiation protection standards: a review

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, L.E.

    1979-10-01

    This paper complements other work which has evaluated the cost impacts of radiation standards on the nuclear industry. It focuses on the approaches to valuation of the health and safety benefits of radiation standards and the actual and appropriate processes of benefit-cost comparison. A brief historical review of the rationale(s) for the levels of radiation standards prior to 1970 is given. The Nuclear Regulatory Commission (NRC) established numerical design objectives for light water reactors (LWRs). The process of establishing these numerical design criteria below the radiation protection standards set in 10 CFR 20 is reviewed. EPA's 40 CFR 190 environmental standards for the uranium fuel cycle have lower values than NRC's radiation protection standards in 10 CFR 20. The task of allocating EPA's 40 CFR 190 standards to the various portions of the fuel cycle was left to the implementing agency, NRC. So whether or not EPA's standards for the uranium fuel cycle are more stringent for LWRs than NRC's numerical design objectives depends on how EPA's standards are implemented by NRC. In setting the numerical levels in Appendix I to 10 CFR 50 and 40 CFR 190 NRC and EPA, respectively, focused on the costs of compliance with various levels of radiation control. A major portion of the paper is devoted to a review and critique of the available methods for valuing health and safety benefits. All current approaches try to estimate a constant value of life and use this to vaue the expected number of lives saved. This paper argues that it is more appropriate to seek a value of a reduction in risks to health and life that varies with the extent of these risks. Additional research to do this is recommended. (DC)

  11. Regional Modeling of Dust Mass Balance and Radiative Forcing over East Asia using WRF-Chem

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Siyu; Zhao, Chun; Qian, Yun; Leung, Lai-Yung R.; Huang, J.; Huang, Zhongwei; Bi, Jianrong; Zhang, Wu; Shi, Jinsen; Yang, Lei; Li, Deshuai; Li, Jinxin

    2014-12-01

    The Weather Research and Forecasting model with Chemistry (WRF-Chem) is used to investigate the seasonal and annual variations of mineral dust over East Asia during 2007-2011, with a focus on the dust mass balance and radiative forcing. A variety of measurements from in-stu and satellite observations have been used to evaluate simulation results. Generally, WRF-Chem reproduces not only the column variability but also the vertical profile and size distribution of mineral dust over and near the dust source regions of East Asia. We investigate the dust lifecycle and the factors that control the seasonal and spatial variations of dust mass balance and radiative forcing over the seven sub-regions of East Asia, i.e. source regions, the Tibetan Plateau, Northern China, Southern China, the ocean outflow region, and Korea-Japan regions. Results show that, over the source regions, transport and dry deposition are the two dominant sinks. Transport contributes to ~30% of the dust sink over the source regions. Dust results in a surface cooling of up to -14 and -10 W m-2, atmospheric warming of up to 20 and 15 W m-2, and TOA cooling of -5 and -8 W m-2 over the two major dust source regions of East Asia, respectively. Over the Tibetan Plateau, transport is the dominant source with a peak in summer. Over identified outflow regions, maximum dust mass loading in spring is contributed by the transport. Dry and wet depositions are the comparably dominant sinks, but wet deposition is larger than dry deposition over the Korea-Japan region, particularly in spring (70% versus 30%). The WRF-Chem simulations can generally capture the measured features of dust aerosols and its radaitve properties and dust mass balance over East Asia, which provides confidence for use in further investigation of dust impact on climate over East Asia.

  12. Estimated clinical benefit of protecting neurogenesis in the developing brain during radiation therapy for pediatric medulloblastoma

    DEFF Research Database (Denmark)

    Blomstrand, M.; Berthelsen, Anne Kiil; Munck af Rosenschöld, Per Martin

    2012-01-01

    to the whole-brain irradiation that is part of standard management. Neurogenesis is very sensitive to radiation, and limiting the radiation dose to the hippocampus and the subventricular zone (SVZ) may preserve neurocognitive function. Radiotherapy plans were created using 4 techniques: standard opposing......We sought to assess the feasibility and estimate the benefit of sparing the neurogenic niches when irradiating the brain of pediatric patients with medulloblastoma (MB) based on clinical outcome data. Pediatric MB survivors experience a high risk of neurocognitive adverse effects, often attributed...

  13. Stabilization and Balance Exercise Benefits in Amyotrophic Lateral Sclerosis: A Case Report

    Directory of Open Access Journals (Sweden)

    Amin Kordi Yoosefinejad

    2014-06-01

    Full Text Available Background: ALS is the most devastating form of motor neuron disease, and the chance of survival is 3 to 5 years after the diagnosis is made. The pathogenesis of the disease is unknown. Several upper and lower motor neuron symptoms such as weakness, gait bradykinesia, and muscle atrophy have been reported. The core muscles are considered to be the center of the functional kinetic chain due to the links with upper and lower limbs. Methods: The patient in this case study was a 42 year-old woman suffering from ALSfor two years prior to the study. She had typical upper and lower motor symptoms, but her chief complaints were inability to walk, standing balance impairment, and a tendency to fall posteriorly. She performed core stabilization exercises, which were done three times per day. She was followed for three months. Results: Core stabilization exercises improved her quality of life, and she could walk independently after three months of exercise. In addition, her tendency toward falling posteriorly was completely alleviated. Conclusion: Core stabilization exercises were beneficial to the patient, and she was satisfied because her quality of life had improved.

  14. Balancing the benefits and risks of public-private partnerships to address the global double burden of malnutrition.

    Science.gov (United States)

    Kraak, Vivica I; Harrigan, Paige B; Lawrence, Mark; Harrison, Paul J; Jackson, Michaela A; Swinburn, Boyd

    2012-03-01

    Transnational food, beverage and restaurant companies, and their corporate foundations, may be potential collaborators to help address complex public health nutrition challenges. While UN system guidelines are available for private-sector engagement, non-governmental organizations (NGO) have limited guidelines to navigate diverse opportunities and challenges presented by partnering with these companies through public-private partnerships (PPP) to address the global double burden of malnutrition. We conducted a search of electronic databases, UN system websites and grey literature to identify resources about partnerships used to address the global double burden of malnutrition. A narrative summary provides a synthesis of the interdisciplinary literature identified. We describe partnership opportunities, benefits and challenges; and tools and approaches to help NGO engage with the private sector to address global public health nutrition challenges. PPP benefits include: raising the visibility of nutrition and health on policy agendas; mobilizing funds and advocating for research; strengthening food-system processes and delivery systems; facilitating technology transfer; and expanding access to medications, vaccines, healthy food and beverage products, and nutrition assistance during humanitarian crises. PPP challenges include: balancing private commercial interests with public health interests; managing conflicts of interest; ensuring that co-branded activities support healthy products and healthy eating environments; complying with ethical codes of conduct; assessing partnership compatibility; and evaluating partnership outcomes. NGO should adopt a systematic and transparent approach using available tools and processes to maximize benefits and minimize risks of partnering with transnational food, beverage and restaurant companies to effectively target the global double burden of malnutrition.

  15. Radiative energy balance of Venus based on improved models of the middle and lower atmosphere

    Science.gov (United States)

    Haus, R.; Kappel, D.; Tellmann, S.; Arnold, G.; Piccioni, G.; Drossart, P.; Häusler, B.

    2016-07-01

    The distribution of sources and sinks of radiative energy forces the atmospheric dynamics. The radiative transfer simulation model described by Haus et al. (2015b) is applied to calculate fluxes and temperature change rates in the middle and lower atmosphere of Venus (0-100 km) covering the energetic significant spectral range 0.125-1000 μm. The calculations rely on improved models of atmospheric parameters (temperature profiles, cloud parameters, trace gas abundances) retrieved from Venus Express (VEX) data (mainly VIRTIS-M-IR, but also VeRa and SPICAV/SOIR with respect to temperature results). The earlier observed pronounced sensitivity of the radiative energy balance of Venus to atmospheric parameter variations is confirmed, but present detailed comparative analyses of possible influence quantities ensure unprecedented insights into radiative forcing on Venus by contrast with former studies. Thermal radiation induced atmospheric cooling rates strongly depend on temperature structure and cloud composition, while heating rates are mainly sensitive to insolation conditions and UV absorber distribution. Cooling and heating rate responses to trace gas variations and cloud mode 1 abundance changes are small, but observed variations of cloud mode 2 abundances and altitude profiles reduce cooling at altitudes 65-80 km poleward of 50°S by up to 30% compared to the neglect of cloud parameter changes. Cooling rate variations with local time below 80 km are in the same order of magnitude. Radiative effects of the unknown UV absorber are modeled considering a proxy that is based on a suitable parameterization of optical properties, not on a specific chemical composition, and that is independent of the used cloud model. The UV absorber doubles equatorial heating near 68 km. Global average radiative equilibrium at the top of atmosphere (TOA) is characterized by the net flux balance of 156 W/m2, the Bond albedo of 0.76, and the effective planetary emission temperature of 228

  16. Response of normal stem cells to ionizing radiation: A balance between homeostasis and genomic stability

    International Nuclear Information System (INIS)

    Harfouche, G.; Martin, M.T.

    2010-01-01

    Stem cells have been described in most adult tissues, where they play a key role in maintaining tissue homeostasis. As they self-renew throughout life, accumulating genetic anomalies can compromise their genomic integrity and potentially give rise to cancer. Stem cells (SCs) may thus be a major target of radiation carcinogenesis. In addition, unrepaired genotoxic damage may cause cell death and stem cell pool depletion, impairing lineage functionality and accelerating aging. Developments in SC biology enabled the characterization of the responses of stem cells to genotoxic stress and their role in tissue damage. We here examine how these cells react to ionizing radiation (IR), and more specifically their radiosensitivity, stress signaling and DNA repair. We first review embryonic SCs, as a paradigm of primitive pluri-potent cells, then three adult tissues, bone marrow, skin and intestine, capable of long-term regeneration and at high risk for acute radiation syndromes and long-term carcinogenesis. We discuss IR disruption of the fine balance between maintenance of tissue homeostasis and genomic stability. We show that stem cell radiosensitivity does not follow a unique model, but differs notably according to the turnover rates of the tissues. (authors)

  17. A methodology for spacecraft technology insertion analysis balancing benefit, cost, and risk

    Science.gov (United States)

    Bearden, David Allen

    Emerging technologies are changing the way space missions are developed and implemented. Technology development programs are proceeding with the goal of enhancing spacecraft performance and reducing mass and cost. However, it is often the case that technology insertion assessment activities, in the interest of maximizing performance and/or mass reduction, do not consider synergistic system-level effects. Furthermore, even though technical risks are often identified as a large cost and schedule driver, many design processes ignore effects of cost and schedule uncertainty. This research is based on the hypothesis that technology selection is a problem of balancing interrelated (and potentially competing) objectives. Current spacecraft technology selection approaches are summarized, and a Methodology for Evaluating and Ranking Insertion of Technology (MERIT) that expands on these practices to attack otherwise unsolved problems is demonstrated. MERIT combines the modern techniques of technology maturity measures, parametric models, genetic algorithms, and risk assessment (cost and schedule) in a unique manner to resolve very difficult issues including: user-generated uncertainty, relationships between cost/schedule and complexity, and technology "portfolio" management. While the methodology is sufficiently generic that it may in theory be applied to a number of technology insertion problems, this research focuses on application to the specific case of small (engineering community are its: unique coupling of the aspects of performance, cost, and schedule; assessment of system level impacts of technology insertion; procedures for estimating uncertainties (risks) associated with advanced technology; and application of heuristics to facilitate informed system-level technology utilization decisions earlier in the conceptual design phase. MERIT extends the state of the art in technology insertion assessment selection practice and, if adopted, may aid designers in determining

  18. Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemma.

    Science.gov (United States)

    Eichler, Hans-Georg; Pignatti, Francesco; Flamion, Bruno; Leufkens, Hubert; Breckenridge, Alasdair

    2008-10-01

    Drug regulatory agencies are increasingly pressed by the challenge of finding the appropriate balance between the need for rapid access to new drugs and the need to ensure comprehensive data on their benefits and risks. This dilemma is not new, but has been made more prominent by recent high-profile drug withdrawals and conflicting demands, including the need to improve the efficiency of drug development on one hand, and the need to avoid exposing patients to unnecessary risks or possibly ineffective treatments on the other. Here, we summarize the current demands by stakeholders and the scientific and regulatory issues at stake, describe existing and emerging regulatory approaches, and speculate on future directions, such as evolution of the current regulatory model from a one-off marketing authorization to a life-cycle approach.

  19. Troughs in Ice Sheets and Other Icy Deposits on Mars: Analysis of Their Radiative Balance

    Science.gov (United States)

    Fountain, A.; Kargel, J.; Lewis, K.; MacAyeal, D.; Pfeffer, T.; Zwally, H. J.

    2000-01-01

    It has long been known that groove-like structures in glaciers and ice sheets can trap more incoming solar radiation than is the case for a 'normal' flat, smooth surface. In this presentation, we shall describe the radiative regimes of typical scarps and troughs on icy surfaces of Mars, and suggest how these features originate and evolve through time. The basis of our analysis is the radiation balance model presented by Pfeffer and Bretherton. Their model considers the visible band radiation regime of a V-shaped groove on a terrestrial ice surface, and shows that absorbed energy can be enhanced by up to 50 percent for grooves with small opening angles and with typical polar values of the solar zenith angle. Our work extends this model by considering: (a) departures from V-shaped geometry, (b) both englacial and surficial dust and debris, and (c) the infrared spectrum. We apply the extended model to various features on the Martian surface, including the spiral-like scarps on the Northern and Southern ice sheets, the large-scale chasms (e.g., Chasm Borealis), and groove-like lineations on valley floors thought to be filled with mixtures of dust and icy substances. In conjunction with study of valley-closure experiments, we suggest that spiral-like scarps and chasms are stable features of the Martian climate regime. We also suggest that further study of scarps and chasms may shed light on the composition (i.e., relative proportions of water ice, carbon-dioxide ice and dust) of the Martian ice sheets and valley fills.

  20. Spatiotemporal Variability of Earth's Radiation Balance Components from Russian Radiometer IKOR-M

    Science.gov (United States)

    Cherviakov, M.

    2016-12-01

    The radiometer IKOR-M was created in National Research Saratov State University for satellite monitoring of the outgoing reflected short-wave radiation, which is one of the components of Earth's radiation budget. Such information can be used in different models of long-term weather forecasts, in researches of climate change trends and in calculation of absorbed solar radiation values and albedo of the Earth-atmosphere system. The IKOR-M product archive is available online at all times. A searchable catalogue of data products is continually updated and users may search and download data products via the Earth radiation balance components research laboratory website as soon as they become available. Two series of measurements from two different IKOR-M are available. The first radiometer had worked from October 2009 to August 2014 and second - from August 2014 to the present. Therefore, there is a period when both radiometers work at the same time. Top-of-atmosphere fluxes deduced from the "Meteor-M" No 1 measurement in August, 2014 show very good agreement with the fluxes determined from "Meteor-M" No 2. The scale relationship of the IKOR-M radiometers on "Meteor - M" No 1 and No 2 satellites found by comparing of the global distribution maps for monthly averaged albedo values. The seasonal and interannual variations of OSR, albedo and ASR were discussed. The variations between SW radiation budget components seem to be within observational uncertainty and natural variability governed by cloudiness, water vapor and aerosol variations. It was assessed spatial and temporal variations of albedo and the absorbed solar radiation over different regions. Latitudinal distributions of albedo and ASR were estimated in more detail. Meridional cross sections over oceans and land were used separately for this estimation. It was shown that the albedo and ASR data received from the radiometer IKOR-M can be used to detect El Nino in the Pacific Ocean. The reported study was funded by

  1. Test models for estimating radiation balance in different scales for Jaboticabal, SP

    Directory of Open Access Journals (Sweden)

    Valquíria de Alencar Beserra

    2012-12-01

    Full Text Available The net radiation (Rn in agroecosystems is the amount of energy that is available in the environment to heating processes of living organisms, air and soil; perspiration of animals and plants; photosynthesis and water evaporation. The Rn defines the type of climate and weather conditions prevailing in a region affecting the availability and thermal water, the fundamental understanding of genotype-environment, which ultimately determine the productivity of the agricultural system. Rn usually is used in models of weather and climate studies. The sustainability and economic viability of zootechnical activity is dependent on the positive interaction between animal and environment. Environmental factors such as water, shading, thermal exchanges sensible heat (conduction, convection and radiation skin and latent heat losses (evaporation and transpiration, conditioned by Rn, must be managed to provide the best results. The present study was conducted to develop and test models for accurate and precise radiation balance on the scales daily, monthly and seasonal ten-day for Jaboticabal - SP, due to the importance of estimates of net radiation for agricultural activities. We used daily meteorological data from weather station located in Jaboticabal, SP (coordinates: 21 ° 14'05 "South, 48 ° 17'09" West, 615m altitude at Universidade Estadual Paulista "Júlio Mesquita Filho" - FCAV/UNESP in a situation of default grass "Bahiagrass" during the period 20/08/2005 to 20/01/2012. The data used were the maximum temperature (Tmax, minimum (Tmin and mean (TMED; maximum relative humidity (URMáx, minimum (URMín and average (URMéd precipitation (mm, average velocity (m/s, Qo, solar radiation (MJ m-2, sunshine (hour meter (MJ m², soil temperature at two depths (Tsoil2CM, Tsoil5CM and class A pan evaporation (TCA (mm. The measures taken by the balance radiometer were taken as a reference to test other models. The models tested were those reported by NORMAN et al

  2. Weighing the risks and benefits of radiation exposure from computed tomography

    International Nuclear Information System (INIS)

    Hogan, Maureen

    2008-01-01

    , children will have a longer life span to develop a cancer resulting from radiation. Also, children are more radiosensitive than adults. In conclusion, the diagnostic benefits for patient treatment using this powerful diagnostic imaging modality must be weighed against the risk of radiation-induced carcinogenesis. Other imaging modalities that do not expose patients to harmful radiation, such as ultrasound and magnetic resonance imaging, can be substituted when clinically appropriate. There must be an improvement in the education of health care professionals prescribing the use of this modality in understanding the life time risk of CT induced cancers; this will invariably decrease the number of scans performed. (author)

  3. Application of the modified Wheeler cap method for radiation efficiency measurement of balanced electrically small antennas in complex environment

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Pivnenko, Sergey; Breinbjerg, Olav

    2010-01-01

    In this paper, application of a modified Wheeler cap method for the radiation efficiency measurement of balanced electrically small antennas is presented. It is shown that the limitations on the cavity dimension can be overcome and thus measurement in a large cavity is possible. The cavity loss...

  4. The benefit of the European User Community from transnational access to national radiation facilities

    DEFF Research Database (Denmark)

    Barrier, Elise; Manuel Braz Fernandes, Francisco; Bujan, Maya

    2014-01-01

    Transnational access (TNA) to national radiation sources is presently provided via programmes of the European Commission by BIOSTRUCT-X and CALIPSO with a major benefit for scientists from European countries. Entirely based on scientific merit, TNA allows all European scientists to realise synchr...... development of the research infrastructure of photon science. Taking into account the present programme structure of HORIZON2020, the European Synchrotron User Organization (ESUO) sees considerable dangers for the continuation of this successful collaboration in the future....... synchrotron radiation experiments for addressing the Societal Challenges promoted in HORIZON2020. In addition, by TNA all European users directly take part in the development of the research infrastructure of facilities. The mutual interconnection of users and facilities is a strong prerequisite for future...

  5. Interagency task force on the health effects of ionizing radiation: report of the work group on care and benefits

    International Nuclear Information System (INIS)

    1979-06-01

    The report examines existing systems for providing care and benefits to persons who may have been injured by radiation exposure and recommends additional guidelines for handling radiation-related claims. The benefits systems examined are Veterans' benefits, Federal Employees Compensation Act, Longshoremen's and Harbor Workers' Compensation Act, State Workers' Compensation programs, Government and private 'back-up' program, Social Security Disability Insurance (Medicare), Supplemental Security Income (Medicaid), private health insurance, government hospitals, and remedies available under the judicial system. The report recommends that the Federal Government develop guidelines to determine the likelihood of a causal relationship between a person's illness and his exposure to radiation; that Federal compensation programs and State programs develop criteria for deciding radiation exposure claims, based on those guidelines; that a national registry of radiation workers be established to maintain individual radiation exposure records; and that the Federal Government annually compile compensation claims based on radiation exposure. Appendixes list those groups of people most likely to be exposed to radiation, and the benefits available under the various compensation programs listed above

  6. The relationship of sick leave benefits, employment patterns, and individual characteristics to radiation therapy-related fatigue.

    Science.gov (United States)

    Poirier, Patricia

    2006-05-03

    To examine the relationship among sick leave benefits, employment patterns, individual characteristics, and fatigue in patients receiving radiation therapy. Prospective, longitudinal design. A community hospital radiation oncology department. 77 patients receiving radiation therapy to the breast, chest, head and neck, pelvis, or prostate. All were employed at the time of diagnosis. The Piper Integrated Fatigue Model guided the study. The Revised Piper Fatigue Scale (PFS), Brief Fatigue Inventory, and a single-item scale were used to measure five dimensions of subjective fatigue. Sick leave, employment, individual characteristics, and fatigue were measured at baseline, weekly during treatment, and at one month post-treatment. Employment patterns, availability of sick leave benefits, and fatigue. Mean total fatigue scores on the PFS ranged from 0-4.77 at baseline (mean = 0.46, SD = 0.93), 0-8.77 at the completion of treatment (mean = 2.84, SD = 2.40), and 0-4.82 at one month post-treatment (mean = 0.77, SD = 1.20). Side effects, education, living situation, age, treatment site, and work were associated with fatigue along the trajectory of radiation therapy. Study participants who were working at the end of radiation had lower fatigue scores than those who were not. Availability of sick leave benefits was associated with employment patterns during treatment. Work may have benefits during radiation therapy but may be affected by radiation therapy-related fatigue. Management of treatment side effects, including fatigue, may help patients remain in the workforce during radiation.

  7. Changes of snow cover, temperature, and radiative heat balance over the Northern Hemisphere

    Science.gov (United States)

    Groisman, Pavel YA.; Karl, Thomas R.; Knight, Richard W.; Stenchikov, Georgiy L.

    1994-01-01

    Contemporary large-scale changes in satellite-derived snow cover were examined over the Northern Hemisphere extratropical land (NEL) areas. These areas encompass 55% of the land in the Northern Hemisphere. Snow cover (S) transient regions, the 'centers of action' relative to interannual variations of snow cover, were identified for the years 1972-1992. During these years a global retreat in snow cover extent (SE) occurred in the second half of the hydrologic year (April-September). Mean annual SE has decreased by 10% (2.3 x 10(exp 6) sq km). Negative trends account for one-third to one-half of the interannual continental variance of SE. The historical influence of S on the planetary albedo and outgoing longwave radiation (OLR) is investigated. The mean annual response of the S feedback on the radiative balance (RB) is negative and suggests a largescale heat redistribution. During autumn and early winter (up to January), however, the feedback of S on the planetary RB may be positive. Only by February does the cooling effect of S (due to albedo increase) dominate the planetary warming due to reduced OLR over the S. Despite a wintertime maximum in SE, the feedback in spring has the greatest magnitude. The global retreat of spring SE should lead to a positive feedback on temperature. Based on observed records of S, changes in RB are calculated that parallel an observed increase of spring temperature during the past 20 years. The results provide a partial explanation of the significant increase in spring surface air temperature observed over the land areas of the Northern Hemisphere during the past century. The mean SE in years with an El Nino and La Nina were also evaluated. El Nino events are generally accompanied by increased SE over the NEL during the first half of the hydrological year. In the second half of the hydrologic year (spring and summer), the El Nino events are accompanied by a global retreat of SE.

  8. Benefits of adaptive radiation therapy in lung cancer as a function of replanning frequency.

    Science.gov (United States)

    Dial, Christian; Weiss, Elisabeth; Siebers, Jeffrey V; Hugo, Geoffrey D

    2016-04-01

    To quantify the potential benefit associated with daily replanning in lung cancer in terms of normal tissue dose sparing and to characterize the tradeoff between adaptive benefit and replanning frequency. A set of synthetic images and contours, derived from weekly active breathing control images of 12 patients who underwent radiation therapy treatment for nonsmall cell lung cancer, is generated for each fraction of treatment using principal component analysis in a way that preserves temporal anatomical trends (e.g., tumor regression). Daily synthetic images and contours are used to simulate four different treatment scenarios: (1) a "no-adapt" scenario that simulates delivery of an initial plan throughout treatment, (2) a "midadapt" scenario that implements a single replan for fraction 18, (3) a "weekly adapt" scenario that simulates weekly adaptations, and (4) a "full-adapt" scenario that simulates daily replanning. An initial intensity modulated radiation therapy plan is created for each patient and replanning is carried out in an automated fashion by reoptimizing beam apertures and weights. Dose is calculated on each image and accumulated to the first in the series using deformable mappings utilized in synthetic image creation for comparison between simulated treatments. Target coverage was maintained and cord tolerance was not exceeded for any of the adaptive simulations. Average reductions in mean lung dose (MLD) and volume of lung receiving 20 Gy or more (V20lung) were 65 ± 49 cGy (p = 0.000 01) and 1.1% ± 1.2% (p = 0.0006), respectively, for all patients. The largest reduction in MLD for a single patient was 162 cGy, which allowed an isotoxic escalation of the target dose of 1668 cGy. Average reductions in cord max dose, mean esophageal dose (MED), dose received by 66% of the heart (D66heart), and dose received by 33% of the heart (D33heart), were 158 ± 280, 117 ± 121, 37 ± 77, and 99 ± 120 cGy, respectively. Average incremental reductions in MLD for

  9. Effects of individual and group exercise programs on pain, balance, mobility and perceived benefits in rheumatoid arthritis with pain and foot deformities.

    Science.gov (United States)

    do Carmo, Carolina Mendes; Almeida da Rocha, Bruna; Tanaka, Clarice

    2017-11-01

    [Purpose] To verify the effects of individual and group exercise programs on pain, balance, mobility and perceived benefits of rheumatoid arthritis patients (RA) with pain and foot deformities. [Subjects and Methods] Thirty patients with RA pain and foot deformity were allocated into two groups: G1: individual exercise program and G2: group exercise program. The variables analyzed were Numerical Rating Scale (NRS) for pain, Berg Balance Scale (BBS) for balance, Timed Up & Go Test (TUG) and Functional Reach (FR) for mobility, and Foot Health Status Questionnaire (FHSQ-Br) for perceived benefits. Both exercise programs consisted of functional rehabilitation exercises and self-care guidance aimed at reducing pain and improving balance and mobility. Intragroup comparisons of variables between A1 (pre-intervention) and A2 (post-intervention) were performed. [Results] Patients in both groups were similar in A1 (pre-intervention) in all the variables analyzed. Comparison between A1 and A2 for each variable showed improvement for G1 in the NRS, BBS, FR, TUG and in four out of ten domains of FHSQ-Br. G2 showed improvement in the NRS, BBS and eight out of ten domains of FHSQ-Br. [Conclusion] Both individual and group programs revealed benefits for patients with RA, however, group exercise programs showed better perception of benefits.

  10. Survival benefits from postoperative radiation therapy on lymph node positive patients with pancreatic adenocarcinoma.

    Science.gov (United States)

    Xia, Zuguang; Jia, Xiaoyan; Chen, Kai; Li, Dapeng; Xie, Jing; Xu, Hong; Mao, Yixiang

    2016-07-19

    The benefit of combining postoperative radiation therapy (PORT) with chemotherapy for resected patients with pancreatic adenocarcinoma is controversial. We sought to determine the effects of PORT on survival in patients with pancreatic adenocarcinoma who underwent primary site surgery. Patients with pancreatic adenocarcinoma receiving primary tumor surgery between 1988 and 2012 were identified from the Surveillance, Epidemiology and End Results (SEER) database. We estimated the association between PORT and other clinicopathologic factors and survival. In total, 5304 patients were identified who underwent pancreatic resection including 2093 patients who had PORT and 3211 patients who had no PORT. Median overall, cancer-specific, and other-cause survival were 19.0, 20.0, and 196.0 months, respectively, with PORT versus 14.0, 15.0, and 163.0 months, respectively, without PORT (all P benefit of PORT was limited to patients with N1 disease. Median overall, cancer-specific, and other-cause survival for patients with N1 disease were 18.0, 18.0, and NA months, respectively, with PORT versus 12.0, 13.0, and 154.0 months, respectively, without PORT (all P benefits might be obtained from PORT on lymph node positive patients with pancreatic adenocarcinoma.

  11. Do the benefits of iodine-131 lipiodol therapy for HCC outweigh the radiation safety issues?

    International Nuclear Information System (INIS)

    Kitchener, M.I.; Barnden, L.R.

    2005-01-01

    Introduction: lodine-131 Lipiodol is a well recognised palliative treatment option for Hepatocellular carcinoma (HCC) unsuitable for surgical resection/transplantation. However, the biological and physical half-life of lodine-131 Lipiodol in this situation has significant implications for radiation protection. Methods: A retrospective study was performed to evaluate the practical radiation issues and treatment efficacy. 22 patients were referred for assessment and 12 received Lipiodol therapy, 5 having multiple doses. Administered doses ranged from 1.0-2.2 GBq. Results: Patients were hospitalised between 4 and 8 days, with discharge rates ranging between 16 and 61uSv/hr at 1 metre. The shorter hospital stays and highest discharge rates related to 2 patients (multiple doses) who had difficulty tolerating the in-hospital isolation. Only 4 patients had discharge rates < 25uSv/hr at 1 metre. 2 with reduced doses. Special exemption was required from the State Radiation Protection Branch (RPB) to allow early discharge. Patients were given a radiation precaution sheet on discharge (as per the FMC program) and asked to observe the restrictions including not returning to work for 14-24 days and avoiding close contact with young children for 25-44 days post-discharge. The measured radiation dose for a patient's spouse/carer was < lOOuSv on 2 occasions. The mean exposure for nurses per patient admission was 9.1 uSv. The TLD readings for the Interventional Radiologist and treating Nuclear Physician remained well within acceptable levels. 4 of the 12 patients have died at a mean of 16.25 months (range 13-20 months) after their first dose of lodine-131 Lipiodol. Of the other 7, 3 now have progressive disease but are alive 18, 36 and 41 months following their first dose. 4 are less than 12 months post-therapy. With the co-operation of the State RPB. the issues relating to radiation protection are manageable and these patients do receive a therapeutic benefit

  12. Comparative analysis of different approaches to the computation of long-wave radiation balance of water air systems

    International Nuclear Information System (INIS)

    Zhukovskii, K.; Nourani, Y.; Monte, L.

    1999-01-01

    In the present paper, the net long-wave radiation balance of the water-air environmental systems is analysed on the base of several semi-empirical approaches. Various theoretical models of infrared atmospheric radiation are reviewed. Factors, affecting their behavior are considered. Special attention is paid to physical conditions under which those models are applicable. Atmospheric and net infrared radiation fluxes are computed and compared under clear and cloudy sky. Results are presented in graphical form. Conclusions are made on the applicability of models considered for evaluating infrared radiation fluxes in environmental conditions of Central Italy. On the base of present analysis Anderson's model is chosen for future calculations of heat budget of lakes in Central Italy [it

  13. Body composition changes and cardiometabolic benefits of a balanced Italian Mediterranean Diet in obese patients with metabolic syndrome.

    Science.gov (United States)

    Di Daniele, Nicola; Petramala, Luigi; Di Renzo, Laura; Sarlo, Francesca; Della Rocca, Domenico Giovanni; Rizzo, Mariagiovanna; Fondacaro, Valentina; Iacopino, Leonardo; Pepine, Carl J; De Lorenzo, Antonino

    2013-06-01

    Metabolic syndrome (MS) is a cluster of metabolic alteration associated with a higher risk of cardiovascular disease and overall mortality than the single alterations alone. The Italian Mediterranean Diet (IMD) can exert a positive effect on cardiovascular risk and related morbidity and mortality. The aim was to evaluate the benefits of dietary intervention based on a typical IMD on body composition, cardiometabolic changes and reduction in cardiovascular disease in patients with MS. Eighty White Italian subjects with MS were prescribed a balanced hypocaloric IMD. We investigated dietary habits and impact of the diet on health status, blood biochemical markers, anthropometric measurements and body composition during a 6-month follow-up period. Body composition, fat mass and distribution were assessed by Dual X-ray absorptiometry. Adherence to the IMD led to a decrease in body weight (102.59 ± 16.82 to 92.39 ± 15.94 kg, p < 0.001), body mass index (BMI) (38.57 ± 6.94 to 35.10 ± 6.76, <0.001) and waist circumference (112.23 ± 12.55 vs 92.42 ± 18.17 cm, p < 0.001). A significant loss of total body fat especially in waist region was observed. The MS was resolved in 52 % of the patients. Significant improvements in systolic and diastolic blood pressure and fasting glucose occurred. Low-density lipoprotein cholesterol was reduced from 128.74 ± 33.18 to 108.76 ± 38.61 mg/dl (p < 0.001), triglycerides from 169.81 ± 80.80 to 131.02 ± 63.88 mg/dl (p < 0.001). The present results suggest that a dietary intervention based on a typical IMD effectively promotes weight loss and reduces the growing burden of cardiovascular risk factors that typifies patients with MS.

  14. Radiation Balance of Urban Materials and Their Thermal Impact in Semi-Desert Region: Mexicali, México Study Case

    Directory of Open Access Journals (Sweden)

    Néstor Santillán-Soto

    2015-10-01

    Full Text Available Net radiation is an essential forcing of climate in the lower layers of Earth’s atmosphere. In this paper, radiation balance is measured in clay soil and green grass, and is compared with three urban materials. These materials: asphalt, concrete and white painted elastomeric polystyrene roofing sheet are widely used in Mexicali, Baja California, México. This study was carried out during August of 2011, the hottest time of the year. The 24-hour average values of net radiation found were: 137.2 W·m−2 for asphalt, 119.1 for concrete, 104.6 for clay soil, 152 for green grass and 29.2 for the polystyrene insulation. The latter two types of materials are likely to be the most effective in reducing urban heat island effects. This variation in the radiation balance has widespread implications for human living conditions, as land cover change tends to be towards surfaces that have higher levels of net radiation.

  15. Low doses of ionizing radiation: Relationship between biological benefit and damage induction. A synopsis

    International Nuclear Information System (INIS)

    Feinendegen, L.E.

    2005-01-01

    Absorption of ionizing radiation in biological tissue stochastically interacts with constituent atoms and molecules and always generates energy deposition (track) events accompanied by bursts of reactive oxygen species (ROS). These ROS are quite similar to those ROS that arise abundantly and constantly by normal oxidative metabolism. ROS effects from either source need attention when assessing radiation-induced alterations in biological structure and function. Endogenous ROS alone induce about 10 6 DNA oxyadducts per cell per day compared to about 5x10 -3 total DNA damage per average cell per day from background radiation exposure (1 mGy per year). At this background level, the corresponding ratio of probabilities of endogenous versus radiogenic DNA double strand breaks (DSBs) per cell per day is about 103 with some 25-40 % of low-LET caused radiogenic DNA-DSBs being of the multi-damage-site type. Radiogenic DNA damage increases in proportion to absorbed dose over a certain dose range. By evolution, tissues possess physiological mechanisms of protection against an array of potentially toxic agents, externally from the environment and endogenously from metabolism, mainly against the abundantly and constantly produced ROS. Ad hoc protection operates at a level that is genetically determined. Following small to moderate perturbation of cell-tissue homeostasis by a toxic impact, adaptive responses develop with a delay and may last from hours to weeks, even months, and aim at protecting the system against renewed insults. Protective responses encompass defense by scavenging mechanisms, DNA repair, damage removal largely by apoptosis and immune responses, as well as changes in cell proliferation. Acute low-dose irradiation below about 0.2 Gy can not only disturb cell-tissue homeostasis but also initiate adaptived protection that appears with a delay of hours and may last from less than a day to months. The balance between damage production and adaptive protection favors

  16. Impact of high resolution radiation doses of mammograms: Evaluation cost-benefit

    International Nuclear Information System (INIS)

    Ferreira, R.; Peixoto, J.; Yacovenco, A.

    1996-01-01

    The purpose of this study was to evaluate the impact of high resolution mammograms over a group of assimptomatic women submitted to the breast exam. The radiation doses to the skin surface and the average dose to the glandular tissue from the cranio caudal view were evaluated. The sample consisted of 407 women throughout Brazil. From these results, in the light of ICRP 60., using the absolute radiobiological risk model, it was possible to estimate the lifetime risk in two ways; firstly the lifetime risk expressed as the excess of radioinduced breast cancer, secondly the lifetime loss for the female population from the age bracket of 30 to 70. that results show that the benefits of high resolutions mammography outweigh the risk to at least, 40 % of efficacy in screening programmes It is therefore concluded that only women of 40 years old or above be included in such a programme

  17. Benefits of controlled ultraviolet radiation in the treatment of dermatological diseases.

    Science.gov (United States)

    Situm, Mirna; Bulat, Vedrana; Majcen, Kristina; Dzapo, Antea; Jezovita, Josip

    2014-12-01

    Phototherapy is a second-line treatment modality for the most common dermatoses that is safe and effective. Most phototherapy regimens denote the use of ultraviolet (UV) radiation of different wavelengths in the management of several dermatoses. Currently, irradiations with broadband UVB (290-320 nm), narrowband UVB (311-313 nm), 308 nm excimer laser, UVA 1 (340-400 nm), UVA with psoralen (PUVA), and extracorporeal photochemotherapy (photopheresis) are being used. Beneficial effects of UV radiation are far from being completely understood. Dermatoses that may benefit from such approach are numerous, with psoriasis, parapsoriasis, atopic dermatitis, cutaneous T-cell lymphomas, morphea, and vitiligo vulgaris as main indications. UVB radiation primarily acts on cells at the epidermis and the epidermodermal junction, while UVA radiation affects epidermal and dermal components, especially blood vessels. UVradiation has im- mediate and delayed effects. Immediate effects are the formation of DNA photoproducts and DNA damage leading to apoptosis of heratinocytes, Langerhans cells, activated T-lymphocytes, neutrophils, macrophages, NK cells, fibroblasts, endothelial cells, and mast-cells, cell membrane damage by lipid peroxidation, and isomerization of chromophores such as urocanic acid. Delayed effects include synthesis of prostaglandins and cytokines that play important roles in immune suppression. Systemic and local immune suppression, alteration in cytokine expression (induction of interleukin-1 (IL-1) receptor antagonist, decrease in IL-2, increase in IL-IO, IL-15), and cell cycle arrest may all contribute to the suppression of disease activity. PUVA is a form of controlled and repeated induction of phototoxic reactions which uses UVA light to activate chemicals known as psoralens. The conjunction of psoralens with epidermal DNA inhibits DNA synthesis and causes cell apoptosis. PUVA also causes an alteration in the expression of cytokines and cytokine receptors

  18. Benefits, risks, and safety of external beam radiation therapy for breast cancer.

    Science.gov (United States)

    Brown, Lindsay C; Mutter, Robert W; Halyard, Michele Y

    2015-01-01

    Breast cancer is a common and complex disease often necessitating multimodality care. Breast cancer may be treated with surgical resection, radiotherapy (RT), and systemic therapy, including chemotherapy, hormonal therapy, and targeted therapies, or a combination thereof. In the past 50 years, RT has played an increasingly significant role in the treatment of breast cancer, resulting in improvements in locoregional control and survival for women undergoing mastectomy who are at high risk of recurrence, and allowing for breast conservation in certain settings. Although radiation provides significant benefit to many women with breast cancer, it is also associated with risks of toxicity, including cardiac and pulmonary toxicity, lymphedema, and secondary malignancy. RT techniques have advanced and continue to evolve dramatically, offering increased precision and reproducibility of treatment delivery and flexibility of treatment schedule. This increased sophistication of RT offers promise of improved outcomes by maintaining or improving efficacy, reducing toxicity, and increasing patient access and convenience. A review of the role of radiation therapy in breast cancer, its associated toxicities and efforts in toxicity reduction is presented.

  19. Great Lakes waters: radiation dose commitments, potential health effects, and cost-benefit considerations

    International Nuclear Information System (INIS)

    Ainsworth, E.J.

    1977-07-01

    In 1972, a Great Lakes Water Quality Agreement was signed by the United States and Canadian Governments. It was stipulated that the operation and effectiveness of the agreement were to be reviewed comprehensively in 1977. Aspects of the agreement concern nondegradation of Great Lakes waters and maintenance of levels of radioactivity or other potential pollutants at levels considered as low as practicable. A refined radioactivity objective of one millirem is proposed in the Water Quality Agreement. The implications of adoption of this objective are not known fully. The Division of Environmental Impact Studies was commissioned by ERDA's Division of Technology Overview to summarize the information available on the current levels of radioactivity in Great Lakes waters, compute radiation-dose commitment (integrated dose over 50 years after consumption of 2.2 liters of water of one year), and to comment on the feasibility and cost-benefit considerations associated with the refined one-millirem objective. Current levels of radioactivity in the waters of Lakes Michigan, Ontario, Erie, and Huron result in dose commitments in excess of 1 mrem for whole body and 6 mrem for bone. Future projections of isotope concentrations in Great lakes water indicate similar dose commitments for drinking water in the year 2050. Reduction of the levels of radioactivity in Great Lakes waters is not feasible, but cost-benefit considerations support removal of 226 Ra and 90 Sr through interceptive technology before water consumption. Adoption of the one-millirem objective is not propitious

  20. Who Benefits From Adjuvant Radiation Therapy for Gastric Cancer? A Meta-Analysis

    International Nuclear Information System (INIS)

    Ohri, Nitin; Garg, Madhur K.; Aparo, Santiago; Kaubisch, Andreas; Tome, Wolfgang; Kennedy, Timothy J.; Kalnicki, Shalom; Guha, Chandan

    2013-01-01

    Purpose: Large randomized trials have demonstrated significant survival benefits with the use of adjuvant chemotherapy or chemoradiation therapy for gastric cancer. The importance of adjuvant radiation therapy (RT) remains unclear. We performed an up-to-date meta-analysis of randomized trials testing the use of RT for resectable gastric cancer. Methods and Materials: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized trials testing adjuvant (including neoadjuvant) RT for resectable gastric cancer. Hazard ratios describing the impact of adjuvant RT on overall survival (OS) and disease-free survival (DFS) were extracted directly from the original studies or calculated from survival curves. Pooled estimates were obtained using the inverse variance method. Subgroup analyses were performed to determine whether the efficacy of RT varies with chemotherapy use, RT timing, geographic region, type of nodal dissection performed, or lymph node status. Results: Thirteen studies met all inclusion criteria and were used for this analysis. Adjuvant RT was associated with a significant improvement in both OS (HR = 0.78, 95% CI: 0.70-0.86, P<.001) and DFS (HR = 0.71, 95% CI: 0.63-0.80, P<.001). In the 5 studies that tested adjuvant chemoradiation therapy against adjuvant chemotherapy, similar effects were seen for OS (HR = 0.83, 95% CI: 0.67-1.03, P=.087) and DFS (HR = 0.77, 95% CI: 0.91-0.65, P=.002). Available data did not reveal any subgroup of patients that does not benefit from adjuvant RT. Conclusion: In randomized trials for resectable gastric cancer, adjuvant RT provides an approximately 20% improvement in both DFS and OS. Available data do not reveal a subgroup of patients that does not benefit from adjuvant RT. Further study is required to optimize the implementation of adjuvant RT for gastric cancer with regard to patient selection and integration with systemic therapy

  1. Benefits of adaptive radiation therapy in lung cancer as a function of replanning frequency

    International Nuclear Information System (INIS)

    Dial, Christian; Weiss, Elisabeth; Hugo, Geoffrey D.; Siebers, Jeffrey V.

    2016-01-01

    Purpose: To quantify the potential benefit associated with daily replanning in lung cancer in terms of normal tissue dose sparing and to characterize the tradeoff between adaptive benefit and replanning frequency. Methods: A set of synthetic images and contours, derived from weekly active breathing control images of 12 patients who underwent radiation therapy treatment for nonsmall cell lung cancer, is generated for each fraction of treatment using principal component analysis in a way that preserves temporal anatomical trends (e.g., tumor regression). Daily synthetic images and contours are used to simulate four different treatment scenarios: (1) a “no-adapt” scenario that simulates delivery of an initial plan throughout treatment, (2) a “midadapt” scenario that implements a single replan for fraction 18, (3) a “weekly adapt” scenario that simulates weekly adaptations, and (4) a “full-adapt” scenario that simulates daily replanning. An initial intensity modulated radiation therapy plan is created for each patient and replanning is carried out in an automated fashion by reoptimizing beam apertures and weights. Dose is calculated on each image and accumulated to the first in the series using deformable mappings utilized in synthetic image creation for comparison between simulated treatments. Results: Target coverage was maintained and cord tolerance was not exceeded for any of the adaptive simulations. Average reductions in mean lung dose (MLD) and volume of lung receiving 20 Gy or more (V20 lung ) were 65 ± 49 cGy (p = 0.000 01) and 1.1% ± 1.2% (p = 0.0006), respectively, for all patients. The largest reduction in MLD for a single patient was 162 cGy, which allowed an isotoxic escalation of the target dose of 1668 cGy. Average reductions in cord max dose, mean esophageal dose (MED), dose received by 66% of the heart (D66 heart ), and dose received by 33% of the heart (D33 heart ), were 158 ± 280, 117 ± 121, 37 ± 77, and 99 ± 120 c

  2. Correction to: Importance of the green color, absorption gradient, and spectral absorption of chloroplasts for the radiative energy balance of leaves.

    Science.gov (United States)

    Kume, Atsushi

    2018-02-21

    The article "Importance of the green color, absorption gradient, and spectral absorption of chloroplasts for the radiative energy balance of leaves", written by Atsushi Kume, was originally published Online First without open access.

  3. Risks and benefits of UV radiation in older people: More of a friend than a foe?

    Science.gov (United States)

    Wright, Fiona; Weller, Richard B

    2015-08-01

    Incident ultraviolet radiation from sunlight varies in intensity and spectrum with season and latitude and has both deleterious and beneficial effects on health in older people. Sunlight is the major preventable risk factor for skin cancer. Non-melanoma skin cancer is the commonest malignancy in a pale skinned older population, but the mortality is extremely low. Intermittent sun exposure is a risk factor for the more dangerous melanoma but chronic sun exposure and outdoor occupation may be protective. Public health advice has tended to concentrate on the dangers of sun exposure despite the absence of any data that increased sun exposure correlates with raised all-cause mortality. Inadequate sun exposure carries its own risks, and the older population are particularly sun deprived as recorded by low serum Vitamin D levels and lack of outdoor activity. Sunlight has health benefits dependently and independently of vitamin D synthesis. Low serum vitamin D levels correlate with increased morbidity and mortality but the direction of association is not always clear. Vitamin D has a causal role in calcium and phosphate metabolism, in skeletal health and probably reduction of colorectal cancer. Evidence is weak for a role in cardiovascular health, but mobilisation of nitric oxide by UVA radiation from nitrate stores in skin, with consequent reduction in BP, may account for the observed reduction in cardiovascular disease and all-cause mortality with increased sun exposure. Advice on healthy sun exposure needs to be reconsidered, with reduction in all-cause mortality and morbidity as the primary end point. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. Low-level radiation: biological interactions, risks, and benefits. A bibliography

    International Nuclear Information System (INIS)

    1978-09-01

    The bibliography contains 3294 references that were selected from the Department of Energy's data base (EDB). The subjects covered are lower-level radiation effects on man, environmental radiation, and other biological interactions of radiation that appear to be applicable to the low-level radiation problem

  5. Low-level radiation: biological interactions, risks, and benefits. A bibliography

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-09-01

    The bibliography contains 3294 references that were selected from the Department of Energy's data base (EDB). The subjects covered are lower-level radiation effects on man, environmental radiation, and other biological interactions of radiation that appear to be applicable to the low-level radiation problem.

  6. An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology.

    Science.gov (United States)

    King, Raymond B; McMahon, Stephen J; Hyland, Wendy B; Jain, Suneil; Butterworth, Karl T; Prise, Kevin M; Hounsell, Alan R; McGarry, Conor K

    2017-01-01

    Over the past two decades, there has been a significant evolution in the technologies and techniques employed within the radiation oncology environment. Over the same period, extensive research into the use of nanotechnology in medicine has highlighted a range of potential benefits to its incorporation into clinical radiation oncology. This short communication describes key tools and techniques that have recently been introduced into specific stages of a patient's radiotherapy pathway, including diagnosis, external beam treatment and subsequent follow-up. At each pathway stage, consideration is given towards how nanotechnology may be combined with clinical developments to further enhance their benefit, with some potential opportunities for future research also highlighted. Prospective challenges that may influence the introduction of nanotechnology into clinical radiotherapy are also discussed, indicating the need for close collaboration between academic and clinical staff to realise the full clinical benefit of this exciting technology.

  7. The balance sheet of benefits and harms of breast cancer population-based screening in Europe: outcome research, practice and future challenges.

    Science.gov (United States)

    Broeders, Mireille; Paci, Eugenio

    2015-11-01

    Breast cancer screening programs are still object of harsh debate. In 2012, the Independent UK Panel reviewed the benefits and harms of mammography screening based on randomized trials and the EUROSCREEN Working Group reviewed European observational outcome studies. The conclusion was that screening programs should continue, while acknowledging that harms, such as the occurrence of false-positive results and overdiagnosis, can have a negative impact on a woman's life. Information on the balance sheet of the benefits and harms of breast cancer screening should help women and their physicians to make an informed choice. The future challenge for breast screening programs is to assess the feasibility, acceptability, effectiveness and impact of risk-based screening in order to maximize benefit-to-harm ratios.

  8. The effect of aerosol on closure of the regionale short-wave radiation balance

    NARCIS (Netherlands)

    Henzing JS; Knap WH; Stammes P; ten Brink HM; Kos GPA; Even A; Swart DPJ; Bergwerff JP; Apituley A; NOP

    2001-01-01

    IPPC reports the aerosol radiative forcing per major aerosol category, like sulphate and fossil fuel derived carbon. Part of this carbon is reflective and part of the material (black carbon "soot") absorbs radiation. We find that in the Netherlands sulphate contributes some 30% to the

  9. A modified Wheeler cap method for radiation efficiency measurement of balanced electrically small antennas

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Pivnenko, Sergey; Breinbjerg, Olav

    2010-01-01

    Measurement of radiation efficiency for ultra small antennas represents a great challenge due to influence of the feeding cable. The Wheeler cap method is often used to measure the radiation efficiency of small antennas. However, it is well applicable for antennas on a ground plane, but not for b......Measurement of radiation efficiency for ultra small antennas represents a great challenge due to influence of the feeding cable. The Wheeler cap method is often used to measure the radiation efficiency of small antennas. However, it is well applicable for antennas on a ground plane...... is that it is wideband, thus does not require any balun, and both the antenna input impedance and radiation efficiency can be obtained. An electrically small loop antenna and a wideband dipole were simulated and measured according to the proposed method and the results of measurements and simulations are presented...

  10. Psychological Benefits of Nonpharmacological Methods Aimed for Improving Balance in Parkinson’s Disease: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Rastislav Šumec

    2015-01-01

    Full Text Available Parkinson’s disease (PD is a serious condition with a major negative impact on patient’s physical and mental health. Postural instability is one of the cardinal difficulties reported by patients to deal with. Neuroanatomical, animal, and clinical studies on nonparkinsonian and parkinsonian subjects suggest an important correlation between the presence of balance dysfunction and multiple mood disorders, such as anxiety, depression, and apathy. Considering that balance dysfunction is a very common symptom in PD, we can presume that by its management we could positively influence patient’s state of mind too. This review is an analysis of nonpharmacological methods shown to be effective and successful for improving balance in patients suffering from PD. Strategies such as general exercise, robotic assisted training, Tai Chi, Qi Gong, Yoga, dance (such as tango or ballet, box, virtual reality-based, or neurofeedback-based techniques and so forth can significantly improve the stability in these patients. Beside this physical outcome, many methods have also shown effect on quality of life, depression level, enjoyment, and motivation to continue in practicing the method independently. The purpose of this review is to provide information about practical and creative methods designed to improve balance in PD and highlight their positive impact on patient’s psychology.

  11. The benefits of using a vacuum-assisted socket system to improve balance and gait in elderly transtibial amputees.

    Science.gov (United States)

    Samitier, C Beatriz; Guirao, Lluis; Costea, Maria; Camós, Josep M; Pleguezuelos, Eulogio

    2016-02-01

    Lower limb amputation leads to impaired balance, ambulation, and transfers. Proper fit of the prosthesis is a determining factor for successful ambulation. Vacuum-assisted socket systems extract air from the socket, which decreases pistoning and probability of soft-tissue injuries and increases proprioception and socket comfort. To investigate the effect of vacuum-assisted socket system on transtibial amputees' performance-based and perceived balance, transfers, and gait. Quasi-experimental before-and-after study. Subjects were initially assessed using their prosthesis with the regular socket and re-evaluated 4 weeks after fitting including the vacuum-assisted socket system. We evaluated the mobility grade using Medicare Functional Classification Level, Berg Balance Scale, Four Square Step Test, Timed Up and Go Test, the 6-Min Walk Test, the Locomotor Capabilities Index, Satisfaction with Prosthesis (SAT-PRO questionnaire), and Houghton Scale. A total of 16 unilateral transtibial dysvascular amputees, mean age 65.12 (standard deviation = 10.15) years. Using the vacuum-assisted socket system, the patients significantly improved in balance, gait, and transfers: scores of the Berg Balance Scale increased from 45.75 (standard deviation = 6.91) to 49.06 (standard deviation = 5.62) (p gait, and transfers in over-50-year-old dysvascular transtibial amputees. This study gives more insight into the use of vacuum-assisted socket systems to improve elderly transtibial dysvascular amputees' functionality and decrease their risk of falls. The use of an additional distal valve in the socket should be considered in patients with a lower activity level. © The International Society for Prosthetics and Orthotics 2014.

  12. Survival benefit of postoperative radiation in papillary meningioma: Analysis of the National Cancer Data Base.

    Science.gov (United States)

    Sumner, Whitney A; Amini, Arya; Hankinson, Todd C; Foreman, Nicholas K; Gaspar, Laurie E; Kavanagh, Brian D; Karam, Sana D; Rusthoven, Chad G; Liu, Arthur K

    2017-01-01

    Papillary meningioma represents a rare subset of World Health Organization (WHO) Grade III meningioma that portends an overall poor prognosis. There is relatively limited data regarding the benefit of postoperative radiation therapy (PORT). We used the National Cancer Data Base (NCDB) to compare overall survival (OS) outcomes of surgically resected papillary meningioma cases undergoing PORT compared to post-operative observation. The NCDB was queried for patients with papillary meningioma, diagnosed between 2004 and 2013, who underwent upfront surgery with or without PORT. Overall survival (OS) was determined using the Kaplan-Meier method. Univariate (UVA) and multivariate (MVA) analyses were performed. In total, 190 patients were identified; 89 patients underwent PORT, 101 patients were observed. Eleven patients received chemotherapy (6 with PORT, 5 without). 2-Year OS was significantly improved with PORT vs. no PORT (93.0% vs. 74.4%), as was 5-year OS (78.5% vs. 62.5%) (hazard ratio [HR], 0.48; 95% confidence interval [CI], 0.27-0.85; p  = 0.01). On MVA, patients receiving PORT had improved OS compared to observation (HR, 0.41; 95% CI, 0.22-0.76; p  = 0.005). On subset analysis by age group, the benefit of PORT vs. no PORT was significant in patients ≤18 years ( n  = 13), with 2-year OS of 85.7% vs. 50.0% (HR, 0.08; 95% CI, 0.01-0.80; p  = 0.032) and for patients >18 years ( n  = 184), with 2-year OS of 94.7% vs. 76.1% (HR, 0.55; 95% CI, 0.31-1.00; p  = 0.049), respectively. In this large contemporary analysis, PORT was associated with improved survival for both adult and pediatric patients with papillary meningioma. PORT should be considered in those who present with this rare, aggressive tumor.

  13. Considerations of health benefit-cost analysis for activities involving ionizing radiation exposure and alternatives. Technical report

    International Nuclear Information System (INIS)

    1977-01-01

    The report deals with development of methodology for the health benefit-cost analysis of activities that result in radiation exposure to humans. It attempts to frame the problems and to communicate the necessary elements of the complex technical process required for this method of analysis. The main thrust of the report is to develop a methodology for analyzing the benefits and costs of these activities. Application of the methodology is demonstrated for nuclear power production and medical uses of radiation, but no definitive analysis is attempted. The report concludes that benefit-cost analysis can be effectively applied to these applications and that it provides a basis for more informed governmental decision-making and for public participation in evaluating the issues of radiation exposure. It notes, however, that for cases where national policy is involved, decisions must inevitably be made on the basis of value judgements to which such analyses can make only limited contributions. An important conclusion is that a significant reduction in radiation exposure to the population is apparently achievable by development of methods for eliminating unproductive medical X-ray exposure

  14. How gamma radiation processing systems are benefiting from the latest advances in information technology

    Science.gov (United States)

    Gibson, Wayne H.; Levesque, Daniel

    2000-03-01

    This paper discusses how gamma irradiation plants are putting the latest advances in computer and information technology to use for better process control, cost savings, and strategic advantages. Some irradiator operations are gaining significant benefits by integrating computer technology and robotics with real-time information processing, multi-user databases, and communication networks. The paper reports on several irradiation facilities that are making good use of client/server LANs, user-friendly graphics interfaces, supervisory control and data acquisition (SCADA) systems, distributed I/O with real-time sensor devices, trending analysis, real-time product tracking, dynamic product scheduling, and automated dosimetry reading. These plants are lowering costs by fast and reliable reconciliation of dosimetry data, easier validation to GMP requirements, optimizing production flow, and faster release of sterilized products to market. There is a trend in the manufacturing sector towards total automation using "predictive process control". Real-time verification of process parameters "on-the-run" allows control parameters to be adjusted appropriately, before the process strays out of limits. Applying this technology to the gamma radiation process, control will be based on monitoring the key parameters such as time, and making adjustments during the process to optimize quality and throughput. Dosimetry results will be used as a quality control measurement rather than as a final monitor for the release of the product. Results are correlated with the irradiation process data to quickly and confidently reconcile variations. Ultimately, a parametric process control system utilizing responsive control, feedback and verification will not only increase productivity and process efficiency, but can also result in operating within tighter dose control set points.

  15. Hypofractionated radiation therapy for prostate cancer: risks and potential benefits in a fiscally conservative health care system.

    Science.gov (United States)

    Aneja, Sanjay; Pratiwadi, Ramya R; Yu, James B

    2012-06-01

    Prostate cancer is the second most common cause of cancer death in American men and represents a significant factor in US health care costs. Radiation therapy serves as one of the most effective treatments for prostate cancer. However, radiation is also an expensive treatment modality and is a significant contributor to the overall rise in the cost of prostate cancer care. Currently, standard external beam radiation therapy for prostate cancer consists of between 75.6 and 81.0 Gy of radiation separated into 1.8- to 2-Gy doses (or "fractions") given daily for between 7 and 9 weeks. Recently, relatively shorter treatment schedules delivering more radiation per treatment-consisting of fractions > 2 Gy-over shorter time periods have been proposed in an effort to curtail rising health care costs and improve patient convenience. However, significant uncertainty still remains regarding outcomes from this type of more condensed treatment, known as"hypofractionated"radiation. In this article, we provide the historical background and rationale for hypofractionated prostate cancer treatment, discuss the potential benefits and risks of prostate hypofractionation, and review the clinical evidence regarding the effectiveness of hypofractionated radiation therapy for prostate cancer.

  16. Balance of longwave radiation employing the rate of solar radiation for Santa Maria, Rio Grande do Sul, Brazil1

    Directory of Open Access Journals (Sweden)

    Evandro Zanini Righi

    Full Text Available New coefficients were determined for the weighting term for cloudiness in the Brunt-Penman equation using the rate of solar radiation (RK in place of the rate of sunshine duration (n/N. The coefficients in the Brutsaert method proposed for daytime in southern Brazil were also tested and adjusted, and the method was selected which gave the more accurate daily results in relation to the original Brunt-Penman equation, for Santa Maria in the state of Rio Grande do Sul, Brazil (RS. Meteorological data covering 2,472 days obtained from the automatic and conventional weather stations in Santa Maria were used. The coefficients were adjusted by linear and nonlinear regression methods depending on the model, using 2/3 of the data. The adjusted equations were tested with the remaining 1/3 of the data. The Brunt-Penman equation modified by the term for cloudiness weighted both for solar radiation incident on the surface with no cloudiness (RK,R and for solar radiation incident at the top of the atmosphere (RK,K, were those that resulted in the best statistical indices relative to the original Brunt-Penman equation. In those equations the boundary conditions, 0.3 ≥ RK,R ≥ 1 or RK,K ≤ 0.22, were imposed. Although having similar statistical indices, a sensitivity analysis showed that the Brutsaert equation and other weightings for cloudiness resulted in larger deviations when compared to the original Brunt-Penman equation, in addition to having greater complexity for practical application.

  17. The benefits of using a bismuth-containing, radiation-absorbing drape in cardiac resynchronization implant procedures.

    Science.gov (United States)

    Jones, Michael A; Cocker, Mary; Khiani, Raj; Foley, Paul; Qureshi, Norman; Wong, Kelvin C K; Rajappan, Kim; Betts, Timothy R

    2014-07-01

    Radiation exposure is a major concern in cardiac device implantation, especially cardiac resynchronization therapy (CRT) procedures. The RadPad™ (Worldwide Innovations & Technologies, Inc., Kansas City, MO, USA), a radiation-attenuating adhesive drape, has been shown to be beneficial in several clinical settings involving fluoroscopy, but less is known about the actual benefits in CRT procedures. Consecutive CRT implants performed with and without a RadPad™ drape over a 10-month period were analyzed. Two thermoluminescent dosimeters (TLDs) were attached to each implanting physician at several locations (adjacent to eyes, center abdomen [outside lead apron], left and right index fingers, and dorsum of the right foot). Results were corrected for background using control TLDs, and normalized to dose-area product (DAP). Thirty-six patients (31 male), 16 with and 20 without the RadPad™, were included in the study. No technical problems were caused by the presence of the radiation-absorbing drape. Time required to position the drape never exceeded 30 seconds, no acute skin reactions were noted, and no radiation-absorbing drape became displaced. Despite a trend toward longer fluoroscopy times and higher DAPs in the radiation-absorbing drape group, radiation exposure was significantly reduced: 65% in the case of the hands and body (P radiation-absorbing drape results in a significant reduction in radiation dose to the implanting physician during CRT procedures. Not only is the dose to the hands reduced, but also the eye and body doses are significantly reduced. The routine use of radiation-absorbing drapes should be considered for all CRT implant procedures in the light of these findings. ©2014 Wiley Periodicals, Inc.

  18. Radiation chemistry of water at low dose rates with emphasis on the energy balance

    International Nuclear Information System (INIS)

    Fletcher, J.W.

    1982-09-01

    There has been considerable interest in absorbed dose water calorimetry. In order to accurately relate the temperature change to the absorbed dose, the energy balance of the overall chemistry of the system must be known. The radiolytic products and their yields are affected by dose rate, dose and added solutes. The yields of the radiolytic products have been calculated using a computer program developed at Atomic Energy of Canada. The chemical energy balance was determined as a function of dose for various dose rates and initial concentrations of hydrogen (H 2 ), oxygen (O 2 ), and hydrogen peroxide (H 2 O 2 ). In solutions containing H 2 O 2 or O 2 and H 2 the chemical reactions were exothermic; in other cases they were endothermic. Approach to equilibrium and equilbrium conditions are discussed

  19. The communication of the radiation risk from CT in relation to its clinical benefit in the era of personalized medicine. Pt. 2. Benefits versus risk of CT

    Energy Technology Data Exchange (ETDEWEB)

    Westra, Sjirk J. [Massachusetts General Hospital, Division of Pediatric Radiology, Boston, MA (United States)

    2014-10-15

    In order to personalize the communication of the CT risk, we need to describe the risk in the context of the clinical benefit of CT, which will generally be much higher, provided a CT scan has a well-established clinical indication. However as pediatric radiologists we should be careful not to overstate the benefit of CT, being aware that medico-legal pressures and the realities of health care economics have led to overutilization of the technology. And even though we should not use previously accumulated radiation dose to a child as an argument against conducting a clinically indicated scan (the ''sunk-cost'' bias), we should consider patients' radiation history in the diagnostic decision process. As a contribution to future public health, it makes more sense to look for non-radiating alternatives to CT in the much larger group of basically healthy children who are receiving occasional scans for widely prevalent conditions such as appendicitis and trauma than to attempt lowering CT use in the smaller group of patients with chronic conditions with a limited life expectancy. When communicating the CT risk with individual patients and their parents, we should acknowledge and address their concerns within the framework of informed decision-making. When appropriate, we may express the individual radiation risk, based on estimates of summated absorbed organ dose, as an order of magnitude rather than as an absolute number, and compare this with the much larger natural cancer incidence over a child's lifetime, and with other risks in medicine and daily life. We should anticipate that many patients cannot make informed decisions on their own in this complex matter, and we should offer our guidance while maintaining respect for patient autonomy. Proper documentation of the informed decision process is important for future reference. In concert with our referring physicians, pediatric radiologists are well-equipped to tackle the complexities

  20. The communication of the radiation risk from CT in relation to its clinical benefit in the era of personalized medicine. Pt. 2. Benefits versus risk of CT

    International Nuclear Information System (INIS)

    Westra, Sjirk J.

    2014-01-01

    In order to personalize the communication of the CT risk, we need to describe the risk in the context of the clinical benefit of CT, which will generally be much higher, provided a CT scan has a well-established clinical indication. However as pediatric radiologists we should be careful not to overstate the benefit of CT, being aware that medico-legal pressures and the realities of health care economics have led to overutilization of the technology. And even though we should not use previously accumulated radiation dose to a child as an argument against conducting a clinically indicated scan (the ''sunk-cost'' bias), we should consider patients' radiation history in the diagnostic decision process. As a contribution to future public health, it makes more sense to look for non-radiating alternatives to CT in the much larger group of basically healthy children who are receiving occasional scans for widely prevalent conditions such as appendicitis and trauma than to attempt lowering CT use in the smaller group of patients with chronic conditions with a limited life expectancy. When communicating the CT risk with individual patients and their parents, we should acknowledge and address their concerns within the framework of informed decision-making. When appropriate, we may express the individual radiation risk, based on estimates of summated absorbed organ dose, as an order of magnitude rather than as an absolute number, and compare this with the much larger natural cancer incidence over a child's lifetime, and with other risks in medicine and daily life. We should anticipate that many patients cannot make informed decisions on their own in this complex matter, and we should offer our guidance while maintaining respect for patient autonomy. Proper documentation of the informed decision process is important for future reference. In concert with our referring physicians, pediatric radiologists are well-equipped to tackle the complexities associated with the communication

  1. The communication of the radiation risk from CT in relation to its clinical benefit in the era of personalized medicine: part 2: benefits versus risk of CT.

    Science.gov (United States)

    Westra, Sjirk J

    2014-10-01

    In order to personalize the communication of the CT risk, we need to describe the risk in the context of the clinical benefit of CT, which will generally be much higher, provided a CT scan has a well-established clinical indication. However as pediatric radiologists we should be careful not to overstate the benefit of CT, being aware that medico-legal pressures and the realities of health care economics have led to overutilization of the technology. And even though we should not use previously accumulated radiation dose to a child as an argument against conducting a clinically indicated scan (the "sunk-cost" bias), we should consider patients' radiation history in the diagnostic decision process. As a contribution to future public health, it makes more sense to look for non-radiating alternatives to CT in the much larger group of basically healthy children who are receiving occasional scans for widely prevalent conditions such as appendicitis and trauma than to attempt lowering CT use in the smaller group of patients with chronic conditions with a limited life expectancy. When communicating the CT risk with individual patients and their parents, we should acknowledge and address their concerns within the framework of informed decision-making. When appropriate, we may express the individual radiation risk, based on estimates of summated absorbed organ dose, as an order of magnitude rather than as an absolute number, and compare this with the much larger natural cancer incidence over a child's lifetime, and with other risks in medicine and daily life. We should anticipate that many patients cannot make informed decisions on their own in this complex matter, and we should offer our guidance while maintaining respect for patient autonomy. Proper documentation of the informed decision process is important for future reference. In concert with our referring physicians, pediatric radiologists are well-equipped to tackle the complexities associated with the communication

  2. Delivery of therapeutic radioisotopes using nanoparticle platforms: potential benefit in systemic radiation therapy.

    Science.gov (United States)

    Zhang, Longjiang; Chen, Hongwei; Wang, Liya; Liu, Tian; Yeh, Julie; Lu, Guangming; Yang, Lily; Mao, Hui

    2010-12-03

    Radiation therapy is an effective cancer treatment option in conjunction with chemotherapy and surgery. Emerging individualized internal and systemic radiation treatment promises significant improvement in efficacy and reduction of normal tissue damage; however, it requires cancer cell targeting platforms for efficient delivery of radiation sources. With recent advances in nanoscience and nanotechnology, there is great interest in developing nanomaterials as multifunctional carriers to deliver therapeutic radioisotopes for tumor targeted radiation therapy, to monitor their delivery and tumor response to the treatment. This paper provides an overview on developing nanoparticles for carrying and delivering therapeutic radioisotopes for systemic radiation treatment. Topics discussed in the review include: selecting nanoparticles and radiotherapy isotopes, strategies for targeting nanoparticles to cancers, together with challenges and potential solutions for the in vivo delivery of nanoparticles. Some examples of using nanoparticle platforms for the delivery of therapeutic radioisotopes in preclinical studies of cancer treatment are also presented.

  3. Delivery of therapeutic radioisotopes using nanoparticle platforms: potential benefit in systemic radiation therapy

    Science.gov (United States)

    Zhang, Longjiang; Chen, Hongwei; Wang, Liya; Liu, Tian; Yeh, Julie; Lu, Guangming; Yang, Lily; Mao, Hui

    2010-01-01

    Radiation therapy is an effective cancer treatment option in conjunction with chemotherapy and surgery. Emerging individualized internal and systemic radiation treatment promises significant improvement in efficacy and reduction of normal tissue damage; however, it requires cancer cell targeting platforms for efficient delivery of radiation sources. With recent advances in nanoscience and nanotechnology, there is great interest in developing nanomaterials as multifunctional carriers to deliver therapeutic radioisotopes for tumor targeted radiation therapy, to monitor their delivery and tumor response to the treatment. This paper provides an overview on developing nanoparticles for carrying and delivering therapeutic radioisotopes for systemic radiation treatment. Topics discussed in the review include: selecting nanoparticles and radiotherapy isotopes, strategies for targeting nanoparticles to cancers, together with challenges and potential solutions for the in vivo delivery of nanoparticles. Some examples of using nanoparticle platforms for the delivery of therapeutic radioisotopes in preclinical studies of cancer treatment are also presented. PMID:24198480

  4. The Role of Cerenkov Radiation in the Pressure Balance of Cool Core Clusters of Galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Lieu, Richard [Department of Physics, University of Alabama, Huntsville, AL 35899 (United States)

    2017-03-20

    Despite the substantial progress made recently in understanding the role of AGN feedback and associated non-thermal effects, the precise mechanism that prevents the core of some clusters of galaxies from collapsing catastrophically by radiative cooling remains unidentified. In this Letter, we demonstrate that the evolution of a cluster's cooling core, in terms of its density, temperature, and magnetic field strength, inevitably enables the plasma electrons there to quickly become Cerenkov loss dominated, with emission at the radio frequency of ≲350 Hz, and with a rate considerably exceeding free–free continuum and line emission. However, the same does not apply to the plasmas at the cluster's outskirts, which lacks such radiation. Owing to its low frequency, the radiation cannot escape, but because over the relevant scale size of a Cerenkov wavelength the energy of an electron in the gas cannot follow the Boltzmann distribution to the requisite precision to ensure reabsorption always occurs faster than stimulated emission, the emitting gas cools before it reheats. This leaves behind the radiation itself, trapped by the overlying reflective plasma, yet providing enough pressure to maintain quasi-hydrostatic equilibrium. The mass condensation then happens by Rayleigh–Taylor instability, at a rate determined by the outermost radius where Cerenkov radiation can occur. In this way, it is possible to estimate the rate at ≈2 M {sub ⊙} year{sup −1}, consistent with observational inference. Thus, the process appears to provide a natural solution to the longstanding problem of “cooling flow” in clusters; at least it offers another line of defense against cooling and collapse should gas heating by AGN feedback be inadequate in some clusters.

  5. Overview of a benefit/risk ratio optimized for a radiation emitting device used in non-destructive testing

    Energy Technology Data Exchange (ETDEWEB)

    Maharaj, H.P., E-mail: H_P_Maharaj@hc-sc.gc.ca [Health Canada, Dept. of Health, Consumer and Clinical Radiaton Protection Bureau, Ottawa, Ontario (Canada)

    2016-03-15

    This paper aims to provide an overview of an optimized benefit/risk ratio for a radiation emitting device. The device, which is portable, hand-held, and open-beam x-ray tube based, is utilized by a wide variety of industries for purposes of determining elemental or chemical analyses of materials in-situ based on fluorescent x-rays. These analyses do not cause damage or permanent alteration of the test materials and are considered a non-destructive test (NDT). Briefly, the key characteristics, principles of use and radiation hazards associated with the Hay device are presented and discussed. In view of the potential radiation risks, a long term strategy that incorporates risk factors and guiding principles intended to mitigate the radiation risks to the end user was considered and applied. Consequently, an operator certification program was developed on the basis of an International Standards Organization (ISO) standard (ISO 20807:2004) and in collaboration with various stake holders and was implemented by a federal national NDT certification body several years ago. It comprises a written radiation safety examination and hands-on training with the x-ray device. The operator certification program was recently revised and the changes appear beneficial. There is a fivefold increase in operator certification (Levels 1 a nd 2) to date compared with earlier years. Results are favorable and promising. An operational guidance document is available to help mitigate radiation risks. Operator certification in conjunction with the use of the operational guidance document is prudent, and is recommended for end users of the x-ray device. Manufacturers and owners of the x-ray devices will also benefit from the operational guidance document. (author)

  6. Use of work–life balance benefits guaranteed by law in Poland – Do size of the enterprise and gender matter?

    Directory of Open Access Journals (Sweden)

    Dorota Merecz-Kot

    2017-10-01

    Full Text Available Background: The paper is aimed at indicating the similarities and differences in use of benefits supporting work–life balance (WLB between women and men working in Polish small/medium and large enterprises. Material and Methods: The sample included 556 workers (311 women, 245 men, aged 20–68 years old employed on the basis of employment contracts for at least a year in Polish enterprises. The respondents completed a questionnaire on the use of benefits guaranteed by the Polish Labour Code, referring to their current workplaces. Results: Women took maternity leaves and returned to the same work position after using childcare leaves more often than men. Men took leaves on demand more often than women. Our results also showed that in comparison to women working in smaller enterprises, those working in large enterprises were more likely to use almost all the analyzed WLB benefits – paid days off to take care of others, educational leaves, leaves on demand, maternity leaves and return to the same work position after childcare leave, reduction of business trips when pregnant or having young children and breastfeeding breaks. The size of enterprise, however, did not differentiate the take-up of benefits among the studied men. Conclusions: Our analysis brought unexpected results on the lack of common availability of the WLB benefits guaranteed by the law in the case of employees who worked on the basis of employment contracts. We also found that women used most of child rearing benefits guaranteed by the law more often than men, which might reflect still a traditional division of child care responsibilities in Poland. Med Pr 2017;68(5:575–581

  7. Definition report on Radiation Indicators in the Environmental Balance and Environmental Outline reports of the Dutch government

    International Nuclear Information System (INIS)

    Pruppers, M.J.M.; Aldenkamp, F.J.; Blaauboer, R.O.; Eggink, G.J.; Kwakman, P.J.M.

    1994-02-01

    For use in future versions of the integrative reports called 'Milieubalans' (Environmental Balance) and 'Milieuverkenning' (Environmental Outlook) RIVM has chosen to present an overview of environmental issues, especially those related to actual and future environmental policies in the Netherlands, in terms of so called target and related steering variables. This definition report describes the elaboration of the above-mentioned approach when it is applied to the complete area of interest: radiation. Together with other definition reports it is supposed to be the justification of choices which are made in defining the sequence of subjects and the minimum set of variables in the future versions of the 'Milieubalans' and the 'Milieuverkenning'. The elaboration is guided by the policy document 'Radiation protection and risk management' (Omgaan met risico's van straling). The policy can be characterized as risk management by focusing directly on the sources of radiation, i.e. steering at the beginning and setting limits at the end of the source-risk chain. Therefore, it is concluded that the complete source-risk chain has to be analyzed and modelled. The area of interest (radiation) is subdivided into areas corresponding to the source categories which are used in the policy document. For each area possible target and steering variables, together with related target and reference values, are collected. Present (diagnosis) and future (prognosis) values of the target variables are also investigated. In conclusion, an indication is given of the activities, which are advisable for the coming years in order to make the target variables operational. The next phases are roughly outlined. 6 tabs., 2 appendices, 19 refs

  8. Modelling radiation and energy balances with Landsat 8 images under different thermohydrological conditions in the Brazilian semi-arid region

    Science.gov (United States)

    de C. Teixeira, Antônio H.; Leivas, Janice F.; Andrade, Ricardo G.; Hernandez, Fernando B. T.; Momesso, Franco R. A.

    2015-10-01

    Four Landsat 8 images were used together with a net of seven agro-meteorological stations for modelling the large-scale radiation and energy balances in the mixed agro-ecosystems inside a semi-arid area composed by irrigated crops and natural vegetation of the Petrolina municipality, Northeast Brazil, along the year 2014. The SAFER algorithm was used to calculate the latent heat flux (λE), net radiation (Rn) was acquired by the Slob equation, ground heat flux (G) was considered as a fraction of Rn and the sensible flux (H) was retrieved by residue in the energy balance equation. For classifying the vegetation into irrigated crops and natural vegetation, the SUREAL algorithm was applied to determine the surface resistance (rs) and threshold values for rs were used to characterize the energy fluxes from these types of vegetated surfaces. Clearly one could see higher λE from irrigated crops than from natural vegetation with some situations of heat horizontal advection increasing its values until 23% times larger than Rn, with respective average λE ranges of 5.7 (64% of Rn) to 7.9 (79% of Rn) and 0.4 (4% of Rn) to 4.3 (37% of Rn) MJ m-2 d-1. The corresponding H mean values were from 1.8 (18% of Rn) to 3.2 (28% of Rn) and 5.4 (60% of Rn) to 9.2 (94% of Rn) MJ m-2 d-1. Average G pixel values ranged from 0.3 to 0.4 MJ m-2 d-1, representing 3 and 4% of Rn for natural vegetation and irrigated crops, respectively.

  9. Nuclear energy and health: and the benefits of low-dose radiation hormesis.

    Science.gov (United States)

    Cuttler, Jerry M; Pollycove, Myron

    2009-01-01

    Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cancers, following exposures are assessed. Radiation hormesis is explained, pointing out that beneficial effects are expected following a low dose or dose rate because protective responses against stresses are stimulated. The notions that no amount of radiation is small enough to be harmless and that a nuclear accident could kill hundreds of thousands are challenged in light of experience: more than a century with radiation and six decades with reactors. If nuclear energy is to play a significant role in meeting future needs, regulatory authorities must examine the scientific evidence and communicate the real health effects of nuclear radiation. Negative images and implications of health risks derived by unscientific extrapolations of harmful effects of high doses must be dispelled.

  10. Do rapid 'superbug' tests pay off? Balance the costs and benefits of leading-edge technology. Interview by Alan Joch.

    Science.gov (United States)

    Morgan, Margie Ann

    2009-02-01

    As hospitals become increasingly sensitive to the health and financial consequences of health care-associated infections (HAIs), a new generation of molecular-based testing technologies promises to significantly shorten the time required to identify "superbugs" and other bacterial infections. The leading-edge techniques promise to reduce costs by helping hospitals quickly determine which patients to isolate because they carry active methicillin-resistant Staphylococcus aureus (MRSA) infections, for example, or which ones to release from prophylactic isolation because they ultimately tested negative for a dangerous infection. But diagnostic speed comes at a price--the costs to perform molecular tests are significantly higher than conventional methods. This challenges hospitals to balance health care expenses with medical efficacy, says molecular testing veteran Margie Morgan, Ph.D., scientific director at Cedars-Sinai Medical Center, Los Angeles. "The rapid methods can be extreme time savers and possibly help a great deal with the isolation of patients. But some of the tests may cost five times what manual methods might be, so there is a price for seeing so much of a reduction in time," she says.

  11. Comparison of fluoro and cine coronary angiography: balancing acceptable outcomes with a reduction in radiation dose.

    Science.gov (United States)

    Olcay, Ayhan; Guler, Ekrem; Karaca, Ibrahim Oguz; Omaygenc, Mehmet Onur; Kizilirmak, Filiz; Olgun, Erkam; Yenipinar, Esra; Cakmak, Huseyin Altug; Duman, Dursun

    2015-04-01

    Use of last fluoro hold (LFH) mode in fluoroscopy, which enables the last live image to be saved and displayed, could reduce radiation during percutaneous coronary intervention when compared with cine mode. No previous study compared coronary angiography radiation doses and image quality between LFH and conventional cine mode techniques. We compared cumulative dose-area product (DAP), cumulative air kerma, fluoroscopy time, contrast use, interobserver variability of visual assessment between LFH angiography, and conventional cine angiography techniques. Forty-six patients were prospectively enrolled into the LFH group and 82 patients into the cine angiography group according to operator decision. Mean cumulative DAP was higher in the cine group vs the LFH group (50058.98 ± 53542.71 mGy•cm² vs 11349.2 ± 8796.46 mGy•cm²; Pcine group vs the LFH group (3.87 ± 5.08 minutes vs 1.66 ± 1.51 minutes; Pcine group vs the LFH group (112.07 ± 43.79 cc vs 88.15 ± 23.84 cc; Pcine and LFH angiography groups (0.66680 ± 0.19309 vs 0.54193 ± 0.31046; P=.20). Radiation doses, contrast use, and fluoroscopy times are lower in fluoroscopic LFH angiography vs cine angiography. Interclass variability of visual stenosis estimation between three operators was not different between cine and LFH groups. Fluoroscopic LFH images conventionally have inferior diagnostic quality when compared with cine coronary angiography, but with new angiographic systems with improved LFH image quality, these images may be adequate for diagnostic coronary angiography.

  12. Energy balance and cost-benefit analysis of biogas production from perennial energy crops pretreated by wet oxidation

    DEFF Research Database (Denmark)

    Uellendahl, Hinrich; Wang, Guangtao; Møller, Henrik B.

    2008-01-01

    Perennial crops need far less energy to plant, require less fertilizer and pesticides, and show a lower negative environmental impact compared with annual crops like for example corn. This makes the cultivation of perennial crops as energy crops more sustainable than the use of annual crops....... The conversion into biogas in anaerobic digestion plants shows however much lower specific methane yields for the raw perennial crops like miscanthus and willow due to their lignocellulosic structure. Without pretreatment the net energy gain is therefore lower for the perennials than for corn. When applying wet...... oxidation to the perennial crops, however, the specific methane yield increases significantly and the ratio of energy output to input and of costs to benefit for the whole chain of biomass supply and conversion into biogas becomes higher than for corn. This will make the use of perennial crops as energy...

  13. What is the best balance of benefits and risks among anti-resorptive therapies for postmenopausal osteoporosis?

    Science.gov (United States)

    Miller, P D; Derman, R J

    2010-11-01

    Pharmacologic osteoporosis therapy, particularly anti-resorptives, is recommended in postmenopausal women with clinical risk factors for fracture. Treatment decisions should be made based on the relative benefit-risk profile in different patient populations. Emerging options [e.g., selective estrogen receptor modulators (SERMs) and denosumab] may hold promise for providing protection from bone loss and for fracture risk reduction.Osteoporosis, the most common clinical disorder of bone metabolism, is characterized by low bone mineral density, deterioration of microarchitecture, and a consequent increase in bone fragility and risk of fracture. Pharmacologic therapy is recommended in postmenopausal women with clinical risk factors for fracture and includes anti-resorptive agents such as bisphosphonates, hormone therapy, SERMs, and calcitonin. The anabolic agent teriparatide (parathyroid hormone) is usually reserved for high-risk patients or those with glucocorticoid-induced osteoporosis. Strontium ranelate, available outside the USA, has both anti-resorptive and anabolic properties. Supplementation with calcium and vitamin D is recommended for all women aged 50 years and older. Bisphosphonates are often considered first-line therapy for osteoporosis and have the largest base of clinical trial data showing efficacy for global fracture risk reduction. Low-dose hormone therapy is appropriate for younger women who are experiencing other menopausal symptoms. In women for whom bisphosphonates are not appropriate or not tolerated or in younger postmenopausal women who have a low risk for hip fracture, SERMs are a suitable treatment option. Calcitonin is designated for patients who are unable or unwilling to tolerate other osteoporosis agents. Emerging options, including newer SERMs (e.g., bazedoxifene and lasofoxifene) and the monoclonal antibody denosumab, may hold promise for providing protection from bone loss and for fracture risk reduction. Because no single agent is

  14. Internet-based ICRP resource for healthcare providers on the risks and benefits of medical imaging that uses ionising radiation.

    Science.gov (United States)

    Demeter, S; Applegate, K E; Perez, M

    2016-06-01

    The purpose of the International Commission on Radiological Protection (ICRP) Committee 3 Working Party was to update the 2001 web-based module 'Radiation and your patient: a guide for medical practitioners' from ICRP. The key elements of this task were: to clearly identify the target audience (such as healthcare providers with an emphasis on primary care); to review other reputable sources of information; and to succinctly publish the contribution made by ICRP to the various topics. A 'question-and-answer' format addressing practical topics was adopted. These topics included benefits and risks of imaging using ionising radiation in common medical situations, as well as pertaining to specific populations such as pregnant, breast-feeding, and paediatric patients. In general, the benefits of medical imaging and related procedures far outweigh the potential risks associated with ionising radiation exposure. However, it is still important to ensure that the examinations are clinically justified, that the procedure is optimised to deliver the lowest dose commensurate with the medical purpose, and that consideration is given to diagnostic reference levels for particular classes of examinations. © The International Society for Prosthetics and Orthotics.

  15. Imaging Radiation Doses and Associated Risks and Benefits in Subjects Participating in Breast Cancer Clinical Trials.

    Science.gov (United States)

    Fresco, Rodrigo; Spera, Gonzalo; Meyer, Carlos; Cabral, Pablo; Mackey, John R

    2015-07-01

    Medical imaging is commonly required in breast cancer (BC) clinical trials to assess the efficacy and/or safety of study interventions. Despite the lack of definitive epidemiological data linking imaging radiation with cancer development in adults, concerns exist about the risks of imaging radiation-induced malignancies (IRIMs) in subjects exposed to repetitive imaging. We estimated the imaging radiation dose and IRIM risk in subjects participating in BC trials. The imaging protocol requirements in 10 phase III trials in the adjuvant and advanced settings were assessed to estimate the effective radiation dose received by a typical and fully compliant subject in each trial. For each study, the excess lifetime attributable cancer risk (LAR) was calculated using the National Cancer Institute's Radiation Risk Assessment Tool, version 3.7.1. Dose and risk calculations were performed for both imaging intensive and nonintensive approaches to reflect the variability in imaging performed within the studies. The total effective imaging radiation dose was 0.4-262.2 mSv in adjuvant trials and 26-241.3 mSv in metastatic studies. The dose variability resulted from differing protocol requirements and imaging intensity approaches, with computed tomography, multigated acquisition scans, and bone scans as the major contributors. The mean LAR was 1.87-2,410/100,000 in adjuvant trials (IRIM: 0.0002%-2.41% of randomized subjects) and 6.9-67.3/100,000 in metastatic studies (IRIM: 0.007%-0.067% of subjects). IRIMs are infrequent events. In adjuvant trials, aligning the protocol requirements with the clinical guidelines' surveillance recommendations and substituting radiating procedures with equivalent nonradiating ones would reduce IRIM risk. No significant risk has been observed in metastatic trials, and potential concerns on IRIMs are not justified. Medical imaging is key in breast cancer (BC) clinical trials. Most of these procedures expose patients to ionizing radiation, and the risk

  16. A simple method to compute the change in earth-atmosphere radiative balance due to a stratospheric aerosol layer

    Science.gov (United States)

    Lenoble, J.; Tanre, D.; Deschamps, P. Y.; Herman, M.

    1982-01-01

    A computer code was developed in terms of a three-layer model for the earth-atmosphere system, using a two-stream approximation for the troposphere and stratosphere. The analysis was limited to variable atmosphere loading by solar radiation over an unperturbed section of the atmosphere. The scattering atmosphere above a Lambertian ground layer was considered in order to derive the planar albedo and the spherical albedo. Attention was given to the influence of the aerosol optical thickness in the stratosphere, the single scattering albedo and asymmetry factor, and the sublayer albedo. Calculations were performed of the zonal albedo and the planetary radiation balance, taking into account a stratospheric aerosol layer containing H2SO4 droplets and volcanic ash. The resulting ground temperature disturbance was computed using a Budyko (1969) climate model. Local decreases in the albedo in the summer were observed in high latitudes, implying a heating effect of the aerosol. An accompanying energy loss of 23-27 W/sq m was projected, which translates to surface temperature decreases of either 1.1 and 0.45 C, respectively, for background and volcanic aerosols.

  17. Dust radiative forcing in snow of the Upper Colorado River Basin: 1. A 6 year record of energy balance, radiation, and dust concentrations

    Science.gov (United States)

    Painter, Thomas H.; Skiles, S. Mckenzie; Deems, Jeffrey S.; Bryant, Ann C.; Landry, Christopher C.

    2012-07-01

    Dust in snow accelerates snowmelt through its direct reduction of snow albedo and its further indirect reduction of albedo by accelerating the growth of snow grains. Since the westward expansion of the United States that began in the mid-19th century, the mountain snow cover of the Colorado River Basin has been subject to five-fold greater dust loading, largely from the Colorado Plateau and Great Basin. Radiative forcing of snowmelt by dust is not captured by conventional micrometeorological measurements, and must be monitored by a more comprehensive suite of radiation instruments. Here we present a 6 year record of energy balance and detailed radiation measurements in the Senator Beck Basin Study Area, San Juan Mountains, Colorado, USA. Data include broadband irradiance, filtered irradiance, broadband reflected flux, filtered reflected flux, broadband and visible albedo, longwave irradiance, wind speed, relative humidity, and air temperatures. The gradient of the snow surface is monitored weekly and used to correct albedo measurements for geometric effects. The snow is sampled weekly for dust concentrations in plots immediately adjacent to each tower over the melt season. Broadband albedo in the last weeks of snow cover ranged from 0.33 to 0.55 across the 6 years and two sites. Total end of year dust concentration in the top 3 cm of the snow column ranged from 0.23 mg g-1 to 4.16 mg g-1. These measurements enable monitoring and modeling of dust and climate-driven snowmelt forcings in the Upper Colorado River Basin.

  18. Fundamentals of risk/benefit analysis in radiation uses in preventive medicine

    International Nuclear Information System (INIS)

    Stieve, F.E.

    1977-01-01

    The term 'risk' stems from the insurance branch. It serves to estimate the probability of making statements about future events on the basis of events which have taken place. Risk estimations are increasingly being made in medicine, especially for determining the advantages and dangers brought to the population by preventive measures. The international radiation protection commission has, for some time, been expressing the dangers of ionising radiation in terms of risk and using these terms as basis for the dose limit values it determined for the professional and general population. This paper deals with possibilities of determining risks in preventive medicine. For doing this, acceptable risk values must be determined and risks resulting from diseases, esp. from those which were not recognized in time, must be compared with those resulting from the application of ionising radiation. (orig.) [de

  19. Optimizing Communication With Parents on Benefits and Radiation Risks in Pediatric Imaging.

    Science.gov (United States)

    Kasraie, Nima; Jordan, David; Keup, Christopher; Westra, Sjirk

    2018-03-13

    Effective radiation risk communication is a core competency for radiology care providers and can prevent and resolve potential conflicts while helping achieve effective public health safeguards. The authors present a synopsis of the challenges to holding such dialogue and review published methods for strengthening and maintaining this discourse. Twelve strategies are discussed in this article that can help alleviate concerns about the iatrogenic risk associated with medical imaging using radiation exposure. Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  20. The effect of sea ice loss on sea salt aerosol concentrations and the radiative balance in the Arctic

    Directory of Open Access Journals (Sweden)

    H. Struthers

    2011-04-01

    Full Text Available Understanding Arctic climate change requires knowledge of both the external and the local drivers of Arctic climate as well as local feedbacks within the system. An Arctic feedback mechanism relating changes in sea ice extent to an alteration of the emission of sea salt aerosol and the consequent change in radiative balance is examined. A set of idealized climate model simulations were performed to quantify the radiative effects of changes in sea salt aerosol emissions induced by prescribed changes in sea ice extent. The model was forced using sea ice concentrations consistent with present day conditions and projections of sea ice extent for 2100. Sea salt aerosol emissions increase in response to a decrease in sea ice, the model results showing an annual average increase in number emission over the polar cap (70–90° N of 86 × 106 m−2 s−1 (mass emission increase of 23 μg m−2 s−1. This in turn leads to an increase in the natural aerosol optical depth of approximately 23%. In response to changes in aerosol optical depth, the natural component of the aerosol direct forcing over the Arctic polar cap is estimated to be between −0.2 and −0.4 W m−2 for the summer months, which results in a negative feedback on the system. The model predicts that the change in first indirect aerosol effect (cloud albedo effect is approximately a factor of ten greater than the change in direct aerosol forcing although this result is highly uncertain due to the crude representation of Arctic clouds and aerosol-cloud interactions in the model. This study shows that both the natural aerosol direct and first indirect effects are strongly dependent on the surface albedo, highlighting the strong coupling between sea ice, aerosols, Arctic clouds and their radiative effects.

  1. Balancing Radiation and Contrast Media Dose in Single-Pass Abdominal Multidetector CT: Prospective Evaluation of Image Quality.

    Science.gov (United States)

    Camera, Luigi; Romano, Federica; Liccardo, Immacolata; Liuzzi, Raffaele; Imbriaco, Massimo; Mainenti, Pier Paolo; Pizzuti, Laura Micol; Segreto, Sabrina; Maurea, Simone; Brunetti, Arturo

    2015-11-01

    As both contrast and radiation dose affect the quality of CT images, a constant image quality in abdominal contrast-enhanced multidetector computed tomography (CE-MDCT) could be obtained balancing radiation and contrast media dose according to the age of the patients. Seventy-two (38 Men; 34 women; aged 20-83 years) patients underwent a single-pass abdominal CE-MDCT. Patients were divided into three different age groups: A (20-44 years); B (45-65 years); and C (>65 years). For each group, a different noise index (NI) and contrast media dose (370 mgI/mL) was selected as follows: A (NI, 15; 2.5 mL/kg), B (NI, 12.5; 2 mL/kg), and C (NI, 10; 1.5 mL/kg). Radiation exposure was reported as dose-length product (DLP) in mGy × cm. For quantitative analysis, signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were calculated for both the liver (L) and the abdominal aorta (A). Statistical analysis was performed with a one-way analysis of variance. Standard imaging criteria were used for qualitative analysis. Although peak hepatic enhancement was 152 ± 16, 128 ± 12, and 101 ± 14 Hounsfield units (P contrast media dose (mL) administered were 476 ± 147 and 155 ± 27 for group A, 926 ± 291 and 130 ± 16 for group B, and 1981 ± 451 and 106 ± 15 for group C, respectively (P contrast media dose administered to patients of different age. Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

  2. Balancing costs and benefits at different stages of medical innovation: a systematic review of Multi-criteria decision analysis (MCDA).

    Science.gov (United States)

    Wahlster, Philip; Goetghebeur, Mireille; Kriza, Christine; Niederländer, Charlotte; Kolominsky-Rabas, Peter

    2015-07-09

    The diffusion of health technologies from translational research to reimbursement depends on several factors included the results of health economic analysis. Recent research identified several flaws in health economic concepts. Additionally, the heterogeneous viewpoints of participating stakeholders are rarely systematically addressed in current decision-making. Multi-criteria Decision Analysis (MCDA) provides an opportunity to tackle these issues. The objective of this study was to review applications of MCDA methods in decisions addressing the trade-off between costs and benefits. Using basic steps of the PRISMA guidelines, a systematic review of the healthcare literature was performed to identify original research articles from January 1990 to April 2014. Medline, PubMed, Springer Link and specific journals were searched. Using predefined categories, bibliographic records were systematically extracted regarding the type of policy applications, MCDA methodology, criteria used and their definitions. 22 studies were included in the analysis. 15 studies (68 %) used direct MCDA approaches and seven studies (32 %) used preference elicitation approaches. Four studies (19 %) focused on technologies in the early innovation process. The majority (18 studies - 81 %) examined reimbursement decisions. Decision criteria used in studies were obtained from the literature research and context-specific studies, expert opinions, and group discussions. The number of criteria ranged between three up to 15. The most frequently used criteria were health outcomes (73 %), disease impact (59 %), and implementation of the intervention (40 %). Economic criteria included cost-effectiveness criteria (14 studies, 64 %), and total costs/budget impact of an intervention (eight studies, 36 %). The process of including economic aspects is very different among studies. Some studies directly compare costs with other criteria while some include economic consideration in a second step. In early

  3. Balancing the risks and benefits associated with cosmetic dentistry - a joint statement by UK specialist dental societies.

    Science.gov (United States)

    Alani, A; Kelleher, M; Hemmings, K; Saunders, M; Hunter, M; Barclay, S; Ashley, M; Djemal, S; Bishop, K; Darbar, U; Briggs, P; Fearne, J

    2015-05-08

    Cosmetic dentistry has become increasingly popular, largely as a result of social trends and increased media coverage. This understandable desire for the alleged 'perfect smile' needs to be tempered with an appropriate awareness of the significant risks associated with invasive cosmetic procedures such as veneers and crowns. Patients need to be properly informed that elective removal of healthy enamel and dentine can result in pulpal injury and poorer periodontal health in the longer term, particularly if they are young. The duty of candour means that they ought to be informed that aggressive reduction of sound tooth tissue is not biologically neutral and results in structural weakening of their teeth. Less invasive procedures such as bleaching on its own or for example, combined with direct resin composite bonding, can satisfy many patient's demands, while still being kinder to teeth and having much better fall-back positions for their future requirements. It is the opinion of the British Endodontic Society, British Society for Restorative Dentistry, Restorative Dentistry UK, Dental Trauma UK, British Society of Prosthodontics and the British Society of Paediatric Dentistry that elective invasive cosmetic dental treatments can result in great benefit to patients, but that some aggressive treatments used to achieve them can produce significant morbidities in teeth which were previously healthy. This is a worrying and growing problem with many ethical, legal and biologic aspects, but many adverse outcomes for patients who request cosmetic dental improvements are preventable by using biologically safer initial approaches to treatment planning and its provision.

  4. Genetic modification to induce CXCR2 overexpression in mesenchymal stem cells enhances treatment benefits in radiation-induced oral mucositis.

    Science.gov (United States)

    Shen, Zongshan; Wang, Jiancheng; Huang, Qiting; Shi, Yue; Wei, Zhewei; Zhang, Xiaoran; Qiu, Yuan; Zhang, Min; Wang, Yi; Qin, Wei; Huang, Shuheng; Huang, Yinong; Liu, Xin; Xia, Kai; Zhang, Xinchun; Lin, Zhengmei

    2018-02-14

    Radiation-induced oral mucositis affects patient quality of life and reduces tolerance to cancer therapy. Unfortunately, traditional treatments are insufficient for the treatment of mucositis and might elicit severe side effects. Due to their immunomodulatory and anti-inflammatory properties, the transplantation of mesenchymal stem cells (MSCs) is a potential therapeutic strategy for mucositis. However, systemically infused MSCs rarely reach inflamed sites, impacting their clinical efficacy. Previous studies have demonstrated that chemokine axes play an important role in MSC targeting. By systematically evaluating the expression patterns of chemokines in radiation/chemical-induced oral mucositis, we found that CXCL2 was highly expressed, whereas cultured MSCs negligibly express the CXCL2 receptor CXCR2. Thus, we explored the potential therapeutic benefits of the transplantation of CXCR 2 -overexpressing MSCs (MSCs CXCR2 ) for mucositis treatment. Indeed, MSCs CXCR2 exhibited enhanced targeting ability to the inflamed mucosa in radiation/chemical-induced oral mucositis mouse models. Furthermore, we found that MSC CXCR2 transplantation accelerated ulcer healing by suppressing the production of pro-inflammatory chemokines and radiogenic reactive oxygen species (ROS). Altogether, these findings indicate that CXCR2 overexpression in MSCs accelerates ulcer healing, providing new insights into cell-based therapy for radiation/chemical-induced oral mucositis.

  5. Image-producing procedures for non-medical applications. Benefits, risks, radiation protection

    International Nuclear Information System (INIS)

    Czarwinski, Renate; Estier, Sybille; Lorenz, Bernd; Vahlbruch, Jan; Henning, Ulrich; Michel, Rolf

    2016-01-01

    A survey is given of image-producing procedures for non-medical applications, and this under technical, juridical and radiation protection aspects. The historical development of these procedures is also described. An example is given for today's practical application.

  6. Anti-Vascular Endothelial Growth Factor Preparations in the Treatment of Retinopathy of Prematurity: Balancing Risks and Benefits.

    Science.gov (United States)

    Chawla, Deepak; Darlow, Brian A

    2016-11-07

    The standard of management of severe retinopathy of prematurity (ROP) is laser ablation of the peripheral retina. Intra-vitreal injection of anti- vascular endothelial growth factor antibodies has emerged as an alternative modality of treatment of ROP. The purpose of this review is to evaluate the current evidence on benefits and risks of using anti-VEGF antibodies for management of ROP. PubMed and Cochrane Register of Clinical Trials were searched for studies evaluating role of anti-VEGF agents in ROP. No study design or language restriction was used. Data were extracted using a data extraction form and presented as a summary of key findings from different study types and designs. Of 143 studies retrieved, 107 were found relevant and further screened. Seventy-three studies reporting original research were selected. These were divided into three categories: pharmacokinetics studies (n=5), observational studies without a control group (n=59) and clinical trials with a control group (n=9). The most commonly used agent was bevacizumab at a dose of 0.625 mg per eye. At this dose bevacizumab administration led to regression of ROP in the majority of cases with type 1 ROP but was associated with sustained reduction in systemic VEGF levels. The most common adverse event after anti-VEGF therapy was recurrence of ROP needing follow up for up to one-year postmenstrual age. Randomized controlled trials demonstrated better anatomical outcome with bevacizumab as compared to laser therapy. Studies lack evidence of long term effect of bevacizumab on retinal vessels, functional visual outcomes and extra-ocular effects. Anti-VEGF agents are effective in causing regression of ROP. However, until adequately powered studies with long term follow-up and recording of more holistic outcomes are available, anti-VEGF agents remain an investigational drug in ROP and should be used only as part of clinical study.

  7. The burden of knowing: balancing benefits and barriers in HIV testing decisions. a qualitative study from Zambia

    Directory of Open Access Journals (Sweden)

    Jürgensen Marte

    2012-01-01

    Full Text Available Abstract Background Client-initiated HIV counselling and testing has been scaled up in many African countries, in the form of voluntary counselling and testing (VCT. Test rates have remained low, with HIV-related stigma being an important barrier to HIV testing. This study explored HIV testing decisions in one rural and one urban district in Zambia with high HIV prevalence and available antiretroviral treatment. Methods Data were collected through 17 in-depth interviews and two focus group discussions with individuals and 10 in-depth interviews with counsellors. Interpretive description methodology was employed to analyse the data. Results 'To know your status' was found to be a highly charged concept yielding strong barriers against HIV testing. VCT was perceived as a diagnostic device and a gateway to treatment for the severely ill. Known benefits of prevention and early treatment were outweighed by a perceived burden of knowing your HIV status related to stigma and fear. The manner in which the VCT services were organised added to this burden. Conclusions This study draws on social stigma theory to enhance the understanding of the continuity of HIV related stigma in the presence of ART, and argues that the burden of knowing an HIV status and the related reluctance to get HIV tested can be understood both as a form of label-avoidance and as strong expressions of the still powerful embodied memories of suffering and death among non-curable AIDS patients over the last decades. Hope lies in the emerging signs of a reduction in HIV related stigma experienced by those who had been tested for HIV. Further research into innovative HIV testing service designs that do not add to the burden of knowing is needed.

  8. Balancing Benefits and Risks of Immortal Data: Participants' Views of Open Consent in the Personal Genome Project.

    Science.gov (United States)

    Zarate, Oscar A; Brody, Julia Green; Brown, Phil; Ramirez-Andreotta, Mónica D; Perovich, Laura; Matz, Jacob

    2016-01-01

    An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become "immortalized" in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched to each other. Reidentification (re-ID), the process of associating an individual's name with data that were considered deidentified, poses risks such as insurance or employment discrimination, social stigma, and breach of the promises often made in informed-consent documents. At the same time, re-ID poses risks to researchers and indeed to the future of science, should re-ID end up undermining the trust and participation of potential research participants. The ethical challenges of online data sharing are heightened as so-called big data becomes an increasingly important research tool and driver of new research structures. Big data is shifting research to include large numbers of researchers and institutions as well as large numbers of participants providing diverse types of data, so the participants' consent relationship is no longer with a person or even a research institution. In addition, consent is further transformed because big data analysis often begins with descriptive inquiry and generation of a hypothesis, and the research questions cannot be clearly defined at the outset and may be unforeseeable over the long term. In this article, we consider how expanded data sharing poses new challenges, illustrated by genomics and the transition to new models of consent. We draw on the experiences of participants in an open data platform-the Personal Genome Project-to allow study participants to contribute their voices to inform ethical consent

  9. Fitness costs and benefits of ultraviolet radiation exposure in marine pelagic copepods

    DEFF Research Database (Denmark)

    Hylander, Samuel; Grenvald, Julie Cornelius; Kiørboe, Thomas

    2014-01-01

    of ultraviolet radiation (UVR), but it is not well known how this affects their fitness. We followed cohorts of the marine copepod Acartia tonsa and assessed how fitness was affected by UVR exposure and a diet rich in UVR-protective sunscreens. Several fitness components including somatic growth, egg quality...... and nauplii production (larvae) were negatively affected by UVR, whereas other components such as size at maturity, survival and length of life were not. Nauplii production through low egg quality was the most influential life-history parameter that changed in response to UVR. There was interaction between...... fitness costs and food source. If copepods were fed a diet rich in UVR-screening MAAs, they were able to maintain and even increase their fitness even though they were exposed to otherwise detrimental radiation. Levels of UVR-protective carotenoids were low in the studied species and a meta...

  10. Defining Value in Radiation Oncology: Approaches to Weighing Benefits vs Costs.

    Science.gov (United States)

    Konski, Andre A

    2017-04-15

    The passage of the Affordable Care Act in 2010 initiated discussion regarding transitioning from a fee-for-service arrangement of care reimbursement to value-based care. Cost-effectiveness analysis (CEA) has been used in the past to quantify value as it relates to the provision of healthcare. New treatments or techniques being compared with other new or existing therapies or approaches to care were determined to be cost-effective if the incremental cost-effectiveness ratio was less than $50,000/life-year or quality-adjusted life-year. This result was accepted as a proxy for value in care delivery. The calculation of value, however, is the inverse of CEA, with units measured in outcome/cost. Given the wealth of medical information now available online, patients are becoming more sophisticated consumers of healthcare, investigating not only outcomes but also costs of care associated with different treatment approaches. Costs to be considered include direct medical costs; the indirect medical costs associated with treatment; and productivity costs resulting, for example, from time lost from work when patients must travel to a cancer center or clinic to receive treatment. Radiation oncologists must be mindful of these costs when designing treatment plans. Increased adoption of hypofractionated radiation treatment strategies (ie, higher radiation doses given over a shorter course of treatment) could increase patient value by reducing direct and indirect medical costs, as well as productivity costs.

  11. Basis for the evaluation of economic benefits from using modules for the development of radiation technology

    International Nuclear Information System (INIS)

    Kodyukov, V.M.; Purtova, M.I.; Smirnova, Z.M.; Semenova, T.D.

    1976-01-01

    A method is discussed for calculating the economic effect obtained by introduction of a designing principle involving standardized units and blocks of various radiation equipment. The method was based on a comparison of the technological and economic factors that could be obtained by using the said principle with similar factors not involving the aggregate principle (used previously in designing various instruments and installations). The formulae are sited for estimating the economy involved in designing and manufacturing aggregated complexes (AC) of the subsystems involved in an aggregated system of instrument making (ASIM) and for evaluating the additional economic effect resulting from reduced AC development time

  12. Delivery of therapeutic radioisotopes using nanoparticle platforms: potential benefit in systemic radiation therapy

    OpenAIRE

    Mao, Hui

    2010-01-01

    Longjiang Zhang1,2 Hongwei Chen1 Liya Wang1 Tian Liu3,4 Julie Yeh1 Guangming Lu2 Lily Yang4,5 Hui Mao1,41Department of Radiology, Emory University School of Medicine, Atlanta, GA, USA; 2Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nangjing, Jiangsu Province, China; 3Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA; 4Emory Winship Cancer Institute, Emory University, Atlanta, GA, USA; 5Department of Surgery, Emory...

  13. Development of the numerical guide for cost-benefit analysis of occupational radiation exposure in the Korean next generation reactor

    International Nuclear Information System (INIS)

    Sohn, K. Y.; Kang, C. S.

    1997-01-01

    The specific purpose of this study is to develop the numerical guide for the cost-benefit analysis of ORE ($/person-Sv reduction) to meet the criterion of ALARA in the design stage of the KNGR. In deriving the guide, the risk factor which is defined by the risk to unit collective radiation exposure dose (deaths/person-Sv) and the monetary value of human life ($/death) are required. The risk factor has been estimated from various clinical data accumulated for a number of years and continuously modified. And the monetary value of human life is usually quantified using the human capital approach. In this study, the risk to radiation exposure perceived by a group of people is investigated through an extensive poll survey conducted among university students in order to modify the existing risk factor for radiation exposure. And in evaluating the monetary value of human life, the QOL factor is introduced in order to incorporate the degree of public welfare or quality of life. As a result of study, a value within the range of 151,000 -172,000 dollars per person-Sv reduction is recommended as the appropriate interim numerical guide for cost-benefit analysis of ORE to meet the criterion of ALARA in the design stage of the KNGR. A poll survey was also conducted in order to see whether the public acceptance cost of nuclear power should be incorporated in developing the guide, and the result of study showed that such a cost does not need to be considered. (author)

  14. A study on cost-benefit analysis and development of numerical guideline for the radiation exposure(II)

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chang Sun; Song, Jae Hyuk; Son, Ki Yoon; Park, Moon Soo; Kim, Chong Uk [Seoul National Univ., Seoul (Korea, Republic of)

    1999-02-15

    The radiation detrimental cost is a representative factor which is used in the cost-benefit analysis. It can be divided into the objective detrimental cost and the subjective detrimental cost. The objective detrimental cost can be quantified through converting human economic value into monetary unit and the subjective detrimental cost can be quantified by estimation of perceived risk of public. The objective of this study is the quantification of the radiation detrimental cost so that the objective detrimental cost and the subjective detrimental cost are estimated, respectively. The main emphasis is laid upon the conversion of human economic value into monetary unit in quantifying the objective detrimental cost. In case of the subjective detrimental cost, perceived risk of public for radiation exposure is measured according to dose levels by questionnaire. And the subjective detrimental costs are derived from the perceived risk for lay public and for occupational workers, respectively. In addition, is also investigated the cost of public acceptance for nuclear power generation.

  15. Medical uses of radiation: retaining the benefit but recognising the harm

    International Nuclear Information System (INIS)

    Valentin, J.; Webb, G.A.M.

    1993-01-01

    This paper review the historical trends and current situation in doses to patients from diagnostic radiology, to investigate whether the optimisation requirement of radiological protection is being fully implemented. The use of constraints as a quantitative indicator is thought likely to help. Computed tomography is studied as an example of the introduction of a new technique with substantial diagnostic benefits but involving substantial doses. The overall conclusion is that the control of patient doses from diagnostic radiology is reasonable - but iT could be better. (55 refs.)

  16. Influence of inhomogeneous surface heat capacity on the estimation of radiative response coefficients in a two-zone energy balance model

    Science.gov (United States)

    Park, Jungmin; Choi, Yong-Sang

    2018-04-01

    Observationally constrained values of the global radiative response coefficient are pivotal to assess the reliability of modeled climate feedbacks. A widely used approach is to measure transient global radiative imbalance related to surface temperature changes. However, in this approach, a potential error in the estimate of radiative response coefficients may arise from surface inhomogeneity in the climate system. We examined this issue theoretically using a simple two-zone energy balance model. Here, we dealt with the potential error by subtracting the prescribed radiative response coefficient from those calculated within the two-zone framework. Each zone was characterized by the different magnitude of the radiative response coefficient and the surface heat capacity, and the dynamical heat transport in the atmosphere between the zones was parameterized as a linear function of the temperature difference between the zones. Then, the model system was forced by randomly generated monthly varying forcing mimicking time-varying forcing like an observation. The repeated simulations showed that inhomogeneous surface heat capacity causes considerable miscalculation (down to -1.4 W m-2 K-1 equivalent to 31.3% of the prescribed value) in the global radiative response coefficient. Also, the dynamical heat transport reduced this miscalculation driven by inhomogeneity of surface heat capacity. Therefore, the estimation of radiative response coefficients using the surface temperature-radiation relation is appropriate for homogeneous surface areas least affected by the exterior.

  17. Summary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet.

    Science.gov (United States)

    Paci, Eugenio

    2012-01-01

    To construct a European 'balance sheet' of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women. From the studies reviewed, the primary benefit of screening, breast cancer mortality reduction, was compared with the main harms, over-diagnosis and false-positive screening results (FPRs). Pooled estimates of breast cancer mortality reduction among invited women were 25% in incidence-based mortality studies and 31% in case-control studies (38% and 48% among women actually screened). Estimates of over-diagnosis ranged from 1% to 10% of the expected incidence in the absence of screening. The combined estimate of over-diagnosis for screened women, from European studies correctly adjusted for lead time and underlying trend, was 6.5%. For women undergoing 10 biennial screening tests, the estimated cumulative risk of a FPR followed by non-invasive assessment was 17%, and 3% having an invasive assessment. For every 1000 women screened biennially from age 50-51 until age 68-69 and followed up to age 79, an estimated seven to nine lives are saved, four cases are over-diagnosed, 170 women have at least one recall followed by non-invasive assessment with a negative result and 30 women have at least one recall followed by invasive procedures yielding a negative result. The chance of saving a woman's life by population-based mammographic screening of appropriate quality is greater than that of over-diagnosis. Service screening in Europe achieves a mortality benefit at least as great as the randomized controlled trials. These outcomes should be communicated to women offered service screening in Europe.

  18. Component greenhouse gas fluxes and radiative balance from two deltaic marshes in Louisiana: Pairing chamber techniques and eddy covariance

    Science.gov (United States)

    Krauss, Ken W.; Holm, Guerry O.; Perez, Brian C.; McWhorter, David E.; Cormier, Nicole; Moss, Rebecca; Johnson, Darren; Neubauer, Scott C; Raynie, Richard C

    2016-01-01

    Coastal marshes take up atmospheric CO2 while emitting CO2, CH4, and N2O. This ability to sequester carbon (C) is much greater for wetlands on a per-area basis than from most ecosystems, facilitating scientific, political, and economic interest in their value as greenhouse gas sinks. However, the greenhouse gas balance of Gulf of Mexico wetlands is particularly understudied. We describe the net ecosystem exchange (NEEc) of CO2 and CH4 using eddy covariance (EC) in comparison with fluxes of CO2, CH4, and N2O using chambers from brackish and freshwater marshes in Louisiana, USA. From EC, we found that 182 g C m-2 y-1 was lost through NEEc from the brackish marsh. Of this, 11 g C m-2 y-1 resulted from net CH4 emissions and the remaining 171 g C m-2 y-1 resulted from net CO2 emissions. In contrast, -290 g C m2 y-1 was taken up through NEEc by the freshwater marsh, with 47 g C m-2 y-1 emitted as CH4 and -337 g C m-2 y-1 taken up as CO2. From chambers, we discovered that neither site had large fluxes of N2O. Sustained-flux greenhouse gas accounting metrics indicated that both marshes had a positive (warming) radiative balance, with the brackish marsh having a substantially greater warming effect than the freshwater marsh. That net respiratory emissions of CO2 and CH4 as estimated through chamber techniques were 2-4 times different from emissions estimated through EC requires additional understanding of the artifacts created by different spatial and temporal sampling footprints between techniques.

  19. Radiation balance of coffee hedgerows Balanço de radiação de renques de cafeeiros

    Directory of Open Access Journals (Sweden)

    Luiz R. Angelocci

    2008-06-01

    Full Text Available The radiation balance of hedgerows is an important variable in studies of mass and energy exchanges between parcial ground cover crops and the atmosphere. This paper describes a device with eight net radiometers encompassing the plants of a hedgerow. The radiometers were moved along a length of hedgerow, in a continuous and reversible movement. The canopy net radiation in this length (Rnc was found by integration of the measurements over the notional cylinder formed. The device showed good performance and provided reliable measurements of Rnc of coffee hedgerows, showing itselfto be an useful technique of measurement in field conditions. Good correlations between Rnc and global solar radiation, turfgrass and coffee crop net radiation were found in 15-min, daytime and 24-hr periods, allowing the possibility of estimating Rnc from these simple measurements. Beer’s law was also used to have an independent estimation of Rnc. A good agreement was found between values of Rnc estimated by this law of attenuation and those integrated by the device in periods of 15 min, with overestimation of 10%, whereas for values integrated over daytime periods the agreement was not satisfactory.A radiação, tanto de ondas curtas como de ondas longas, absorvida por um renque de plantas de uma cultura que cobre de forma descontínua o solo, é uma variável importante para os estudos das trocas de massa e de energia com a atmosfera. Este trabalho apresenta um dispositivo que movimenta oito saldo-radiômetros dispostos em torno de um renque. O movimento de ida e volta ao longo de um trecho de um renque, permite a integração do saldo de radiação na superfície de um cilindro nocional de medidas, representando o balanço de radiação (Rnc do trecho amostrado. O equipamento apresentou um bom desempenho quando empregado em dois cafezais, mostrando potencial para a realização de medidas de campo, com valores medidos confiáveis. Foram obtidas boas correla

  20. Assessing wildlife benefits and carbon storage from restored and natural coastal marshes in the Nisqually River Delta: Determining marsh net ecosystem carbon balance

    Science.gov (United States)

    Anderson, Frank; Bergamaschi, Brian; Windham-Myers, Lisamarie; Woo, Isa; De La Cruz, Susan; Drexler, Judith; Byrd, Kristin; Thorne, Karen M.

    2016-06-24

    Working in partnership since 1996, the U.S. Fish and Wildlife Service and the Nisqually Indian Tribe have restored 902 acres of tidally influenced coastal marsh in the Nisqually River Delta (NRD), making it the largest estuary-restoration project in the Pacific Northwest to date. Marsh restoration increases the capacity of the estuary to support a diversity of wildlife species. Restoration also increases carbon (C) production of marsh plant communities that support food webs for wildlife and can help mitigate climate change through long-term C storage in marsh soils.In 2015, an interdisciplinary team of U.S. Geological Survey (USGS) researchers began to study the benefits of carbon for wetland wildlife and storage in the NRD. Our primary goals are (1) to identify the relative importance of the different carbon sources that support juvenile chinook (Oncorhynchus tshawytscha) food webs and contribute to current and historic peat formation, (2) to determine the net ecosystem carbon balance (NECB) in a reference marsh and a restoration marsh site, and (3) to model the sustainability of the reference and restoration marshes under projected sea-level rise conditions along with historical vegetation change. In this fact sheet, we focus on the main C sources and exchanges to determine NECB, including carbon dioxide (CO2) uptake through plant photosynthesis, the loss of CO2 through plant and soil respiration, emissions of methane (CH4), and the lateral movement or leaching loss of C in tidal waters.

  1. A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions.

    Science.gov (United States)

    Habs, Michael; Binder, Karin; Krauss, Stefan; Müller, Karolina; Ernst, Brigitte; Valentini, Luzia; Koller, Michael

    2017-07-07

    Humans are exposed to pyrrolizidine alkaloids (PA) through different sources, mainly from contaminated foodstuff. Teas and herbal infusions (T&HI) can be contaminated by PA producing weed. PA can possess toxic, mutagenic, genotoxic, and carcinogenic properties. Thus, possible health risks for the general population are under debate. There is a strong safety record for T&HI and additionally epidemiological evidence for the preventive effects of regular tea consumption on cardiovascular events and certain types of cancer. There is no epidemiological evidence, however, for human risks of regular low dose PA exposure. Recommended regulatory PA-threshold values are based on experimental data only, accepting big uncertainties. If a general risk exists through PA contaminated T&HI, it must be small compared to other frequently accepted risks of daily living and the proven health effects of T&HI. Decision making should be based on a balanced riskbenefit analysis. Based on analyses of the scientific data currently available, it is concluded that the benefits of drinking T&HI clearly outweigh the negligible health risk of possible PA contamination. At the same time, manufacturers must continue their efforts to secure good product quality and to be transparent on their measures of quality control and risk communication.

  2. A Balanced Risk–Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)—The Case of Tea and Herbal Infusions

    Science.gov (United States)

    Habs, Michael; Binder, Karin; Krauss, Stefan; Müller, Karolina; Ernst, Brigitte; Valentini, Luzia; Koller, Michael

    2017-01-01

    Humans are exposed to pyrrolizidine alkaloids (PA) through different sources, mainly from contaminated foodstuff. Teas and herbal infusions (T&HI) can be contaminated by PA producing weed. PA can possess toxic, mutagenic, genotoxic, and carcinogenic properties. Thus, possible health risks for the general population are under debate. There is a strong safety record for T&HI and additionally epidemiological evidence for the preventive effects of regular tea consumption on cardiovascular events and certain types of cancer. There is no epidemiological evidence, however, for human risks of regular low dose PA exposure. Recommended regulatory PA-threshold values are based on experimental data only, accepting big uncertainties. If a general risk exists through PA contaminated T&HI, it must be small compared to other frequently accepted risks of daily living and the proven health effects of T&HI. Decision making should be based on a balanced riskbenefit analysis. Based on analyses of the scientific data currently available, it is concluded that the benefits of drinking T&HI clearly outweigh the negligible health risk of possible PA contamination. At the same time, manufacturers must continue their efforts to secure good product quality and to be transparent on their measures of quality control and risk communication. PMID:28686224

  3. A Balanced Risk–Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA—The Case of Tea and Herbal Infusions

    Directory of Open Access Journals (Sweden)

    Michael Habs

    2017-07-01

    Full Text Available Humans are exposed to pyrrolizidine alkaloids (PA through different sources, mainly from contaminated foodstuff. Teas and herbal infusions (T&HI can be contaminated by PA producing weed. PA can possess toxic, mutagenic, genotoxic, and carcinogenic properties. Thus, possible health risks for the general population are under debate. There is a strong safety record for T&HI and additionally epidemiological evidence for the preventive effects of regular tea consumption on cardiovascular events and certain types of cancer. There is no epidemiological evidence, however, for human risks of regular low dose PA exposure. Recommended regulatory PA-threshold values are based on experimental data only, accepting big uncertainties. If a general risk exists through PA contaminated T&HI, it must be small compared to other frequently accepted risks of daily living and the proven health effects of T&HI. Decision making should be based on a balanced riskbenefit analysis. Based on analyses of the scientific data currently available, it is concluded that the benefits of drinking T&HI clearly outweigh the negligible health risk of possible PA contamination. At the same time, manufacturers must continue their efforts to secure good product quality and to be transparent on their measures of quality control and risk communication.

  4. The influence of diffusion and of reabsorption of radiation on the particle and energy balance of an infinitely long quasi-cylindrical discharge in hydrogen gas

    International Nuclear Information System (INIS)

    Goedheer, W.J.

    1978-09-01

    A numerical study of the pressure and temperature profiles of an infinitely long quasi-cylindrical discharge in hydrogen gas is presented. In particular the influence of the diffusion of atoms in the ground state and the reabsorption of Lyman-α and Lyman-β radiation on both the particle balance and the energy balance of the discharge is studied. Because the transport of the charged particles is corrected for toroidal effects in the regime of high collisionality which is present in the discharge, the model is quasi-cylindrical. The results obtained show an increase of the neutral density on the axis and of the ion and electron density near the wall of the discharge, as compared with earlier calculations in which both diffusion and reabsorption of radiation were neglected. The results are in agreement with measurements in the 'Ringboog' experiment. (Auth.)

  5. Therapeutic benefits in grid irradiation on Tomotherapy for bulky, radiation-resistant tumors.

    Science.gov (United States)

    Narayanasamy, Ganesh; Zhang, Xin; Meigooni, Ali; Paudel, Nava; Morrill, Steven; Maraboyina, Sanjay; Peacock, Loverd; Penagaricano, Jose

    2017-08-01

    Spatially fractionated radiation therapy (SFRT or grid therapy) has proven to be effective in management of bulky tumors. The aim of this project is to study the therapeutic ratio (TR) of helical Tomotherapy (HT)-based grid therapy using linear-quadratic cell survival model. HT-based grid (or HT-GRID) plan was generated using a patient-specific virtual grid pattern of high-dose cylindrical regions using MLCs. TR was defined as the ratio of normal tissue surviving fraction (SF) under HT-GRID irradiation to an open debulking field of an equivalent dose that result in the same tumor cell SF. TR was estimated from DVH data on ten HT-GRID patient plans with deep seated, bulky tumor. Dependence of the TR values on radiosensitivity of the tumor cells and prescription dose was analyzed. The mean ± standard deviation (SD) of TR was 4.0 ± 0.7 (range: 3.1-5.5) for the 10 patients with single fraction maximum dose of 20 Gy to GTV assuming a tumor cell SF at 2 Gy (SF2 t ) value of 0·5. In addition, the mean ± SD of TR values for SF2 t values of 0.3 and 0.7 were found to be 1 ± 0.1 and 18.0 ± 5.1, respectively. Reducing the prescription dose to 15 and 10 Gy lowered the respective TR values to 2.0 ± 0.2 and 1.2 ± 0.04 for a SF2 t value of 0.5. HT-GRID therapy demonstrates a significant therapeutic advantage over uniform dose from an open field irradiation for the same tumor cell kill. TR increases with the radioresistance of the tumor cells and with prescription dose.

  6. Mammographic screening in BRCA1 mutation carriers postponed until age 40: Evaluation of benefits, costs and radiation risks using models.

    Science.gov (United States)

    Obdeijn, Inge-Marie; Heijnsdijk, Eveline A M; Hunink, M G Myriam; Tilanus-Linthorst, Madeleine M A; de Koning, Harry J

    2016-08-01

    BRCA1 mutation carriers are offered screening with magnetic resonance imaging (MRI) and mammography. The aim of this study was to weigh benefits and risks of postponing mammographic screening until age 40. With the MISCAN microsimulation model two screening protocols were evaluated: 1) the current Dutch guidelines: annual MRI from age 25-60, annual mammography from age 30-60, and biennial mammography in the nationwide program from age 60-74, and 2) the modified protocol: with annual mammography postponed until age 40. A cost-effectiveness analysis was performed. The risks of radiation-induced breast cancer mortality were estimated with absolute and relative exposure-risk models of the 7th Biological Effects of Ionising Radiation Committee. Current screening guidelines prevent 13,139 breast cancer deaths per 100,000 BRCA1 mutation carriers. Postponing mammography until age 40 would increase breast cancer deaths by 23 (0.17%), but would also reduce radiation-induced breast cancer deaths by 15 or 105 using the absolute and relative risk model respectively per 100,000 women screened. The estimated net effect is an increase of eight or a reduction of 82 breast cancer deaths per 100,000 women screened (depending on the risk model used). The incremental cost of mammograms between age 30-39 is €272,900 per life year gained. The modified protocol may be slightly less effective or even better than the current guidelines. The high cost-savings justify a possible small loss of effectiveness. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Survival benefit of adding chemotherapy to intensity modulated radiation in patients with locoregionally advanced nasopharyngeal carcinoma.

    Directory of Open Access Journals (Sweden)

    Xuemei Ji

    Full Text Available BACKGROUND: To evaluate the contribution of chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC treated by intensity modulated radiotherapy (IMRT and to identify the optimal combination treatment strategy. PATIENTS AND METHODS: Between 2006 and 2010, 276 patients with stage II-IVb NPC were treated by IMRT alone or IMRT plus chemotherapy. Cisplatin-based chemotherapy included neoadjuvant or concurrent, or neoadjuvant plus concurrent protocols. The IMRT alone and chemoradiotherapy groups were well-matched for prognostic factors, except N stage, with more advanced NPC in the chemoradiotherapy arm. RESULTS: With a mean follow-up of 33.8 months, the 3-year actuarial rates of overall survival (OS, metastasis-free survival (MFS, relapse-free survival (RFS, and disease-free survival (DFS were 90.3%, 84.2%, 80.3%, and 69.2% for all of the patients, respectively. Compared with the IMRT alone arm, patients treated by concurrent chemoradiotherapy had a significantly better DFS (HR = 2.64; 95% CI, 1.12-6.22; P = 0.03, patients with neoadjuvant-concurrent chemoradiotherapy had a significant improvement in RFS and DFS (HR = 4.03; 95% CI, 1.35-12.05; P = 0.01 and HR = 2.43; 95% CI, 1.09-5.44; P = 0.03, neoadjuvant chemoradiotherapy provided no significant benefit in OS, MFS, RFS, and DFS. Stage group and alcohol consumption were prognostic factors for OS and N stage was a significant predictor for DFS. CONCLUSIONS: Addition of concurrent or neoadjuvant-concurrent chemotherapy to IMRT is available to prolong RFS or DFS for locoregionally advanced NPC. Such work could be helpful to guide effective individualized therapy.

  8. Potential benefits of crawl position for prone radiation therapy in breast cancer.

    Science.gov (United States)

    Boute, Bert; De Neve, Wilfried; Speleers, Bruno; Van Greveling, Annick; Monten, Christel; Van Hoof, Tom; Van de Velde, Joris; Paelinck, Leen; De Gersem, Werner; Vercauteren, Tom; Detand, Jan; Veldeman, Liv

    2017-07-01

    To investigate crawl position with the arm at the treated side alongside the body and at the opposite side above the head for prone treatment in patients requiring breast and regional lymph node irradiation. Patient support devices for crawl position were built for CT simulation and treatment. An asymmetric fork design resulted from an iterative process of prototype construction and testing. The fork's large horn supports the hemi-thorax, shoulder, and elevated arm at the nontreated side and the head. The short, narrow horn supports the arm at the treated side. Between both horns, the treated breast and its regional lymph nodes are exposed. Endpoints were pain, comfort, set-up precision, beam access to the breast and lymph nodes, and plan dose metrics. Pain and comfort were tested by volunteers (n = 9); set-up precision, beam access, and plan dose metrics were tested by means of a patient study (n = 10). The AIO™ (Orfit, Wijnegem, Belgium) prone breastboard (AIO™) was used as a reference regarding comfort and set-up precision. Pain at the sternum, the ipsilateral shoulder, upper arm, and neck was lower in crawl position than with bilateral arm elevation on AIO™. Comfort and set-up precision were better on the crawl prototype than on AIO™. In crawl position, beam directions in the coronal and near-sagittal planes have access to the breast or regional lymph nodes without traversing device components. Plan comparison between supine and crawl positions showed better dose homogeneity for the breast and lymph node targets and dose reductions to all organs at risk for crawl position. Radiation therapy for breast and regional lymph nodes in crawl position is feasible. Good comfort and set-up precision were demonstrated. Planning results support the hypothesis that breast and regional lymph nodes can be treated in crawl position with less dose to organs at risk and equal or better dose distribution in the target volumes than in supine position. The crawl

  9. Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial

    Energy Technology Data Exchange (ETDEWEB)

    Hamstra, Daniel A., E-mail: Daniel.Hamstra@gmail.com [Texas Oncology, Texas Center for Proton Therapy, Irving, Texas (United States); Mariados, Neil [Associated Medical Professionals of NY, PLLC, Syracuse, New York (United States); Sylvester, John [21st Century Oncology, Inc, Lakewood Ranch, East Bradenton, Florida (United States); Shah, Dhiren [Western New York Urology Associates, LLC, Doing Business as Cancer Care of WNY, Cheektowaga, New York (United States); Karsh, Lawrence [The Urology Center of Colorado, Denver, Colorado (United States); Hudes, Richard [Chesapeake Urology Associates, Doing Business as Chesapeake Urology Research Associates (The Prostate Center), Owings Mills, Maryland (United States); Beyer, David [Arizona Oncology Services Foundation, Phoenix, Arizona (United States); Kurtzman, Steven [Urological Surgeons of Northern California Inc, Campbell, California (United States); Bogart, Jeffrey [The Research Foundation of State University of New York/State University of New York Upstate Medical University, Syracuse, New York (United States); Hsi, R. Alex [Peninsula Cancer Center, Poulsbo, Washington (United States); Kos, Michael [Urology Nevada, Reno, Nevada (United States); Ellis, Rodney [University Hospitals Case Medical Center, Cleveland, Ohio (United States); Logsdon, Mark [Sutter Health Sacramento Sierra Region, Doing Business as Sutter Institute for Medical Research, Sacramento, California (United States); Zimberg, Shawn [Advanced Radiation Centers of New York, Lake Success, New York (United States); Forsythe, Kevin [Oregon Urology Institute, Springfield, Oregon (United States); Zhang, Hong [University of Rochester, Rochester, New York (United States); Soffen, Edward [CentraState Medical Center, Freehold, New Jersey (United States); Francke, Patrick [Carolina Regional Cancer Center, LLC, 21st Century Oncology, Inc, Myrtle Beach, South Carolina (United States); Mantz, Constantine [21st Century Oncology, Inc, Fort Meyers, Florida (United States); and others

    2017-04-01

    Purpose: SpaceOAR, a Food and Drug Administration–approved hydrogel intended to create a rectal–prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. Methods and Materials: Cumulative (Common Terminology Criteria for Adverse Events, version 4.0) toxicity was evaluated using the log-rank test. Quality of life (QOL) was examined using the Expanded Prostate Cancer Index Composite (EPIC), and the mean changes from baseline in the EPIC domains were tested using repeated measures models. The proportions of men with minimally important differences (MIDs) in each domain were tested using repeated measures logistic models with prespecified thresholds. Results: The 3-year incidence of grade ≥1 (9.2% vs 2.0%; P=.028) and grade ≥2 (5.7% vs 0%; P=.012) rectal toxicity favored the spacer arm. Grade ≥1 urinary incontinence was also lower in the spacer arm (15% vs 4%; P=.046), with no difference in grade ≥2 urinary toxicity (7% vs 7%; P=0.7). From 6 months onward, bowel QOL consistently favored the spacer group (P=.002), with the difference at 3 years (5.8 points; P<.05) meeting the threshold for a MID. The control group had a 3.9-point greater decline in urinary QOL compared with the spacer group at 3 years (P<.05), but the difference did not meet the MID threshold. At 3 years, more men in the control group than in the spacer group had experienced a MID decline in bowel QOL (41% vs 14%; P=.002) and urinary QOL (30% vs 17%; P=.04). Furthermore, the control group were also more likely to have experienced large declines (twice the MID) in bowel QOL (21% vs 5%; P=.02) and urinary QOL (23% vs 8%; P=.02). Conclusions: The benefit of a hydrogel spacer in

  10. Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial.

    Science.gov (United States)

    Hamstra, Daniel A; Mariados, Neil; Sylvester, John; Shah, Dhiren; Karsh, Lawrence; Hudes, Richard; Beyer, David; Kurtzman, Steven; Bogart, Jeffrey; Hsi, R Alex; Kos, Michael; Ellis, Rodney; Logsdon, Mark; Zimberg, Shawn; Forsythe, Kevin; Zhang, Hong; Soffen, Edward; Francke, Patrick; Mantz, Constantine; Rossi, Peter; DeWeese, Theodore; Daignault-Newton, Stephanie; Fischer-Valuck, Benjamin W; Chundury, Anupama; Gay, Hiram; Bosch, Walter; Michalski, Jeff

    2017-04-01

    SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. Cumulative (Common Terminology Criteria for Adverse Events, version 4.0) toxicity was evaluated using the log-rank test. Quality of life (QOL) was examined using the Expanded Prostate Cancer Index Composite (EPIC), and the mean changes from baseline in the EPIC domains were tested using repeated measures models. The proportions of men with minimally important differences (MIDs) in each domain were tested using repeated measures logistic models with prespecified thresholds. The 3-year incidence of grade ≥1 (9.2% vs 2.0%; P=.028) and grade ≥2 (5.7% vs 0%; P=.012) rectal toxicity favored the spacer arm. Grade ≥1 urinary incontinence was also lower in the spacer arm (15% vs 4%; P=.046), with no difference in grade ≥2 urinary toxicity (7% vs 7%; P=0.7). From 6 months onward, bowel QOL consistently favored the spacer group (P=.002), with the difference at 3 years (5.8 points; Pgroup had a 3.9-point greater decline in urinary QOL compared with the spacer group at 3 years (Pgroup than in the spacer group had experienced a MID decline in bowel QOL (41% vs 14%; P=.002) and urinary QOL (30% vs 17%; P=.04). Furthermore, the control group were also more likely to have experienced large declines (twice the MID) in bowel QOL (21% vs 5%; P=.02) and urinary QOL (23% vs 8%; P=.02). The benefit of a hydrogel spacer in reducing the rectal dose, toxicity, and QOL declines after image guided intensity modulated radiation therapy for prostate cancer was maintained or increased with a longer follow-up period, providing

  11. Increased Radiation but No Benefits in Pedicle Screw Accuracy With Navigation versus a Freehand Technique in Scoliosis Surgery.

    Science.gov (United States)

    Urbanski, Wiktor; Jurasz, Wojciech; Wolanczyk, Michal; Kulej, Miroslaw; Morasiewicz, Piotr; Dragan, Szymon Lukasz; Zaluski, Rafal; Miekisiak, Grzegorz; Dragan, Szymon Feliks

    2018-02-08

    thoracic spine. Patients undergoing navigated pedicle screw placement received a greater mean radiation dose than those whose screws were placed freehand (1071 ± 447 mGy-cm versus 391 ± 53 mGy-cm; mean difference, 680 mGy-cm; 95% confidence interval, 217-2053 mGy-cm; p benefits of pedicle screw placement with CT-based navigation, but the patients experienced greater exposure to radiation. Level III, therapeutic study.

  12. Assessment of the Interactions Among Tropospheric Aerosol Loading, Radiative Balance and Clouds Through Examination of Their Multi-decadal Trends

    Science.gov (United States)

    While aerosol radiative effects have been recognized as some of the largest sources of uncertainty among the forcers of climate change, the verification of the spatial and temporal variability of aerosol radiative forcing has remained challenging. Anthropogenic emissions of prima...

  13. Availability and the use of work-life balance benefits guaranteed by the Polish Labour Code among workers employed on the basis of employment contracts in small and medium enterprises.

    Science.gov (United States)

    Andysz, Aleksandra; Jacukowicz, Aleksandra; Stańczak, Aleksander; Drabek, Marcin

    2016-01-01

    Polish Labour Code provides employees with a range of solutions (benefits) supporting them in achieving balance between work and private life. This paper was aimed at indicating availability and the use of legal benefits supporting work-life balance (WLB) among Polish workers of small and medium enterprises. The study sample included 219 respondents, aged 22-64, working in small and medium enterprises and employed on the basis of employment contracts for at least a year. The respondents completed a questionnaire on availability and the use of benefits guaranteed by the Polish Labour Code, referring to their current workplaces. Most frequently the studied employees took sick leave because of one's own illness and leave on demand. In our sample, 45% of the women took maternity leave and 26% of the men took paternity leave. The respondents took educational and parental leave the least frequently. More than half of the respondents (58%) did not return to the same position after leave devoted to childcare, even though they had such a possibility. In fact, most of work-life balance benefits guaranteed by law were available to the employees of small and medium enterprises, regardless of their gender. Availability and the use of the majority of benefits were similar among the women and men. Availability of benefits depended on the specificity of industry and a profession, thus, future research on work-life balance policy should control for variables related to the character of work. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  14. Fire-induced albedo change and surface radiative forcing in sub-Saharan Africa savanna ecosystems: Implications for the energy balance

    Science.gov (United States)

    Dintwe, Kebonye; Okin, Gregory S.; Xue, Yongkang

    2017-06-01

    Surface albedo is a critical parameter that controls surface energy balance. In dryland ecosystems, fires play a significant role in decreasing surface albedo, resulting in positive radiative forcing. Here we investigate the long-term effect of fire on surface albedo. We devised a method to calculate short-, medium-, and long-term effect of fire-induced radiative forcing and their relative effects on energy balance. We used Moderate Resolution Imaging Spectroradiometer (MODIS) data in our analysis, covering different vegetation classes in sub-Saharan Africa (SSA). Our analysis indicated that mean short-term fire-induced albedo change in SSA was -0.022, -0.035, and -0.041 for savannas, shrubland, and grasslands, respectively. At regional scale, mean fire-induced albedo change in savannas was -0.018 and -0.024 for northern sub-Saharan of Africa and the southern hemisphere Africa, respectively. The short-term mean fire-induced radiative forcing in burned areas in sub-Saharan Africa (SSA) was 5.41 W m-2, which contributed continental and global radiative forcings of 0.25 and 0.058 W m-2, respectively. The impact of fire in surface albedo has long-lasting effects that varies with vegetation type. The long-term energetic effects of fire-induced albedo change and associated radiative forcing were, on average, more than 19 times greater across SSA than the short-term effects, suggesting that fires exerted far more radiative forcing than previously thought. Taking into account the actual duration of fire's effect on surface albedo, we conclude that the contribution of SSA fires, globally and throughout the year, is 0.12 W m-2. These findings provide crucial information on possible impact of fire on regional climate variability.

  15. The impacts of urban surface characteristics on radiation balance and meteorological variables in the boundary layer around Beijing in summertime

    Science.gov (United States)

    Liu, Ruiting; Han, Zhiwei; Wu, Jian; Hu, Yonghong; Li, Jiawei

    2017-11-01

    In this study, some key geometric and thermal parameters derived from recent field and satellite observations in Beijing were collected and incorporated into WRF-UCM (Weather Research and Forecasting) model instead of previous default ones. A series of sensitivity model simulations were conducted to investigate the influences of these parameters on radiation balance, meteorological variables, turbulence kinetic energy (TKE), as well as planetary boundary layer height (PBLH) in regions around Beijing in summer 2014. Model validation demonstrated that the updated parameters represented urban surface characteristics more realistically and the simulations of meteorological variables were evidently improved to be closer to observations than the default parameters. The increase in building height tended to increase and slightly decrease surface air temperature at 2 m (T2) at night and around noon, respectively, and to reduce wind speed at 10 m (WS10) through a day. The increase in road width led to significant decreases in T2 and WS10 through the whole day, with the maximum changes in early morning and in evening, respectively. Both lower surface albedo and inclusion of anthropogenic heat (AH) resulted in increases in T2 and WS10 over the day, with stronger influence from AH. The vertical extension of the impact of urban surface parameters was mainly confined within 300 m at night and reached as high as 1600 m during daytime. The increase in building height tended to increase TKE and PBLH and the TKE increase was larger at night than during daytime due to enhancements of both mechanical and buoyant productions. The increase in road width generally reduced TKE and PBLH except for a few hours in the afternoon. The lower surface albedo and the presence of AH consistently resulted in increases of TKE and PBLH through both day and night. The increase in building height induced a slight divergence by day and a notable convergence at night, whereas the increase in road width

  16. Benefit of Adjuvant Brachytherapy Versus External Beam Radiation for Early Breast Cancer: Impact of Patient Stratification on Breast Preservation

    International Nuclear Information System (INIS)

    Smith, Grace L.; Jiang, Jing; Buchholz, Thomas A.; Xu, Ying; Hoffman, Karen E.; Giordano, Sharon H.; Hunt, Kelly K.; Smith, Benjamin D.

    2014-01-01

    Purpose: Brachytherapy after lumpectomy is an increasingly popular breast cancer treatment, but data concerning its effectiveness are conflicting. Recently proposed “suitability” criteria guiding patient selection for brachytherapy have never been empirically validated. Methods: Using the Surveillance, Epidemiology, and End Results–Medicare linked database, we compared women aged 66 years or older with invasive breast cancer (n=28,718) or ductal carcinoma in situ (n=7229) diagnosed from 2002 to 2007, treated with lumpectomy alone, brachytherapy, or external beam radiation therapy (EBRT). The likelihood of breast preservation, measured by subsequent mastectomy risk, was compared by use of multivariate proportional hazards, further stratified by American Society for Radiation Oncology (ASTRO) brachytherapy suitability groups. We compared 1-year postoperative complications using the χ 2 test and 5-year local toxicities using the log-rank test. Results: For patients with invasive cancer, the 5-year subsequent mastectomy risk was 4.7% after lumpectomy alone (95% confidence interval [CI], 4.1%-5.4%), 2.8% after brachytherapy (95% CI, 1.8%-4.3%), and 1.3% after EBRT (95% CI, 1.1%-1.5%) (P<.001). Compared with lumpectomy alone, brachytherapy achieved a more modest reduction in adjusted risk (hazard ratio [HR], 0.61; 95% CI, 0.40-0.94) than achieved with EBRT (HR, 0.22; 95% CI, 0.18-0.28). Relative risks did not differ when stratified by ASTRO suitability group (P=.84 for interaction), although ASTRO “suitable” patients did show a low absolute subsequent mastectomy risk, with a minimal absolute difference in risk after brachytherapy (1.6%; 95% CI, 0.7%-3.5%) versus EBRT (0.8%; 95% CI, 0.6%-1.1%). For patients with ductal carcinoma in situ, EBRT maintained a reduced risk of subsequent mastectomy (HR, 0.40; 95% CI, 0.28-0.55; P<.001), whereas the small number of patients treated with brachytherapy (n=179) precluded definitive comparison with lumpectomy alone. In

  17. Radiation

    International Nuclear Information System (INIS)

    2013-01-01

    The chapter one presents the composition of matter and atomic theory; matter structure; transitions; origin of radiation; radioactivity; nuclear radiation; interactions in decay processes; radiation produced by the interaction of radiation with matter

  18. Balancing benefits and costs in a 4°C world: the need for and challenges of natural-social science dialogue

    Science.gov (United States)

    Kopp, R. E.

    2012-12-01

    Making wise policy decisions regarding mitigation, adaptation and geoengineering requires fair assessments of the risks of both action and inaction. Such assessments necessitate dialogue between natural and social scientists. Recent attempts by the U.S. government to estimate the social cost of carbon (SCC) for use in balancing the benefits and costs of proposed mitigatory regulations highlight some of the challenges involved. Among them: (1) Scale: The costs and benefits of adaptation decisions generally take place locally, while the benefits of mitigation accrue globally. Most studies to inform adaptation decision have, quite reasonably, taken place at the local scale, but this has left globally aggregate estimates of climate risk in a fairly tenuous state, engaging only a handful of economists. More accurate assessments, needed for making critical policy decisions as we approach a 4°C world, will require both better top-down analyses and a better framework for integrating bottom-up analyses. (2) Historical validation: Integrated assessment models have not been subject to validation studies, such as the historical runs used to test physical climate models. Conducting such studies for impact analyses will require the integration and further development of statistical analyses of the human impact of past and ongoing climate change. If models don't work for a 0.8°C world, there's no reason to think they'll work for a 4°C world. (3) Looking beyond a 4°C world: A world that reaches 4°C in this century may exceed it in the next century; and even if temperature is stabilized, understanding the economic impacts of 4°C warming will require more than the current approach of extrapolating from 2°C impacts. Natural scientists and social scientists need to work together to estimate damage calibration points for considerably warmer conditions. Recent work on the loss of physiologically habitable regions in a >8°C warmer world is a rare step in this direction (Sherwood

  19. Vertical Distribution of Radiation and Energy Balance Partitioning Within and Above a Lodgepole Pine Stand Recovering from a Recent Insect Attack

    Science.gov (United States)

    Emmel, Carmen; Paul-Limoges, Eugenie; Black, Thomas Andrew; Christen, Andreas

    2013-11-01

    The current outbreak of mountain pine beetle (MPB) that started in the late 1990s in British Columbia, Canada, is the largest ever recorded in the north American native habitat of the beetle. The killing of trees is expected to change the vertical distribution of net radiation () and the partitioning of latent () and sensible () heat fluxes in the different layers of an attacked forest canopy. During an intensive observation period in the summer of 2010, eddy-covariance flux and radiation measurements were made at seven heights from ground level up to 1.34 times the canopy height in an MPB-attacked open-canopy forest stand in the interior of British Columbia, Canada. The lodgepole pine dominated stand with a rich secondary structure (trees and understorey not killed by the beetle) was first attacked by the MPB in 2003 and received no management. In this study, the vertical distribution of the energy balance components and their sources and sinks were analyzed and energy balance closure (EBC) was determined for various levels within the canopy. The low stand density resulted in approximately 60 % of the shortwave irradiance and 50 % of the daily total reaching the ground. Flux divergence calculations indicated relatively strong sources of latent heat at the ground and where the secondary structure was located. Only very weak sources of latent heat were found in the upper part of the canopy, which was mainly occupied by dead lodgepole pine trees. was the dominant term throughout the canopy, and the Bowen ratio () increased with height in the canopy. Soil heat flux () accounted for approximately 4 % of . Sensible heat storage in the air () was the largest of the energy balance storage components in the upper canopy during daytime, while in the lower canopy sensible heat storage in the boles () and biochemical energy storage () were the largest terms. was almost constant from the bottom to above the canopy. , and latent heat storage in the air () varied more than

  20. Summary of the evidence of breast cancer service screening outcomes in Europe and first estimate of the benefit and harm balance sheet

    DEFF Research Database (Denmark)

    Paci, Eugenio; Lynge, Elsebeth

    2012-01-01

    To construct a European 'balance sheet' of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women.......To construct a European 'balance sheet' of key outcomes of population-based mammographic breast cancer screening, to inform policy-makers, stakeholders and invited women....

  1. Beneficios del Tai Chi Chuan en la osteoartritis, el equilibrio y la calidad de vida (Tai Chi Chuan benefits on osteoarthritis, balance and quality of life

    Directory of Open Access Journals (Sweden)

    Pedro Jesús Jiménez-Martín

    2013-04-01

    TCC utilizado (el estilo practicado, la dosificación, la experiencia de los instructores, la altura en las posturas, el tiempo de ejecución de cada forma, etc.AbstractAim: This paper reviews international scientific studies aimed at determining the benefits of practicing Tai Chi Chuan (TCC on knee osteoarthritis (OR, balance, fear of falling, and quality of life. Method: A bibliographic search of eight international databases was undertaken (Medline-Pubmed, Scirus, Pascal, ScienceDirect, SportDiscus, Science Citation Index, BIOSIS y PsycINFO until April 2012. Results: A total of 74 studies were analyzed, 13 of them corresponding to systematic reviews and 61 to specific studies (42 randomized controlled studies (EAC and 19 non-controlled studies (ENC. In particular, 11 studies were analyzed regarding knee osteoarthritis (7 EAC and 4 ENC, 32 regarding balance-fear of falling (26 EAC and 6 ENC, and 30 regarding quality of life (18 EAC and 12 ENC. Conclusion: The effects of TCC on knee osteoarthritis are contradictory although a positive tendency was observed regarding control of pain and the improvement of physical functionality. Regarding the effects on balance-fear of falling, a significant improvement in static and dynamic balance was observed as well as confidence in terms of fear of falling. Regarding quality of life, TCC practice improves emotional well-being, self-perception and physical well-being. The obtained results should be treated with some caution since many of the studies examined show methodological weaknesses in the design (small samples, lack of inclusion and exclusion criteria for the participants, deficiencies in the statistical analyses, lack of standardization in the measurement of results, etc., and the specific information about the conditions of the TCC program applied (style practised, dose, experience of the instructors, posture height, time spent carrying out each form.

  2. The health benefits of UV radiation exposure through vitamin D production or non-vitamin D pathways. Blood pressure and cardiovascular disease.

    Science.gov (United States)

    Weller, Richard B

    2017-03-16

    The detrimental effects of ultraviolet radiation are well known. Skin cancer, photo-aging, and induction or exacerbation of photosensitive dermatoses have been the focus of most photobiological research since 1928 when Findlay confirmed the carcinogenicity of ultraviolet radiation using a murine model of skin cancer. The epidemiological, mechanistic and clinical trial data have enabled the classification by the International Agency for Research on Cancer of ultraviolet radiation as a Group 1 ('sufficient evidence') carcinogen for human skin. Public health advice in most developed countries with a pale-skinned population following this has advocated limiting exposure to sunlight through use of clothing, sunblock and behavioural alterations. Despite this plethora of data, one striking omission is evidence that ultraviolet radiation shortens life, and as I will lay out in this chapter, epidemiological and now mechanistic data suggest that UV may have significant benefits on health and in particular cardiovascular health.

  3. Request for Funding for the 2016 Air & Waste Management Association Visibility Conference on Atmospheric Optics:Aerosols, Visibility, and the Radiative Balance

    International Nuclear Information System (INIS)

    Eatough, Delbert

    2016-01-01

    This international conference will provide a technical forum on advances in the scientific understanding of the effects of aerosols on urban, regional, continental, and global-scale haze and the radiative balance. The conference will take a multipronged approach and address scientific topics (e.g., related to measurements, modeling, etc.) as well as regulatory and policy issues. There will be sessions on black and brown carbon, as recent research has shown the importance of these particles for radiative forcing. In addition, there will be sessions related to the synergistic and increasing concerns of the effects of atmospheric nitrogen and carbonaceous material on haze, climate change, and nitrogen deposition on ecosystems. Conference learning will be enhanced with a half day excursion and hikes in Grand Teton National Park and a Night Sky Program.

  4. Request for Funding for the 2016 Air & Waste Management Association Visibility Conference on Atmospheric Optics:Aerosols, Visibility, and the Radiative Balance

    Energy Technology Data Exchange (ETDEWEB)

    Eatough, Delbert [Brigham Young Univ., Provo, UT (United States)

    2016-06-01

    This international conference will provide a technical forum on advances in the scientific understanding of the effects of aerosols on urban, regional, continental, and global-scale haze and the radiative balance. The conference will take a multipronged approach and address scientific topics (e.g., related to measurements, modeling, etc.) as well as regulatory and policy issues. There will be sessions on black and brown carbon, as recent research has shown the importance of these particles for radiative forcing. In addition, there will be sessions related to the synergistic and increasing concerns of the effects of atmospheric nitrogen and carbonaceous material on haze, climate change, and nitrogen deposition on ecosystems. Conference learning will be enhanced with a half day excursion and hikes in Grand Teton National Park and a Night Sky Program.

  5. Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgery.

    Science.gov (United States)

    Albert, Jeffrey M; Liu, Diane D; Shen, Yu; Pan, I-Wen; Shih, Ya-Chen Tina; Hoffman, Karen E; Buchholz, Thomas A; Giordano, Sharon H; Smith, Benjamin D

    2012-08-10

    The role of radiation therapy (RT) after conservative surgery (CS) remains controversial for older patients with breast cancer. Guidelines based on recent clinical trials have suggested that RT may be omitted in selected patients with favorable disease. However, it is not known whether this recommendation should extend to other older women. Accordingly, we developed a nomogram to predict the likelihood of long-term breast preservation with and without RT. We used Surveillance, Epidemiology, and End Results-Medicare data to identify 16,092 women age 66 to 79 years treated with CS between 1992 and 2002, using claims to identify receipt of RT and subsequent mastectomy. Time to mastectomy was estimated using the Kaplan-Meier method. Cox proportional hazards models determined the effect of covariates on mastectomy-free survival (MFS). A nomogram was developed to predict 5- and 10-year MFS, given associated risk factors, and bootstrap validation was performed. With a median follow-up of 7.2 years, the overall 5- and 10-year MFS rates were 98.1% (95% CI, 97.8% to 98.3%) and 95.4% (95% CI, 94.9% to 95.8%), respectively. In multivariate analysis, age, race, tumor size, estrogen receptor status, and receipt of RT were predictive of time to mastectomy and were incorporated into the nomogram. Nodal status was also included given a significant interaction with RT. The resulting nomogram demonstrated good accuracy in predicting MFS, with a bootstrap-corrected concordance index of 0.66. This clinically useful tool predicts 5- and 10-year MFS among older women with early breast cancer using readily available clinicopathologic factors and can aid individualized clinical decision making by estimating predicted benefit from RT.

  6. Effectiveness, usability, and cost-benefit of a virtual reality-based telerehabilitation program for balance recovery after stroke: a randomized controlled trial.

    Science.gov (United States)

    Lloréns, Roberto; Noé, Enrique; Colomer, Carolina; Alcañiz, Mariano

    2015-03-01

    First, to evaluate the clinical effectiveness of a virtual reality (VR)-based telerehabilitation program in the balance recovery of individuals with hemiparesis after stroke in comparison with an in-clinic program; second, to compare the subjective experiences; and third, to contrast the costs of both programs. Single-blind, randomized, controlled trial. Neurorehabilitation unit. Chronic outpatients with stroke (N=30) with residual hemiparesis. Twenty 45-minute training sessions with the telerehabilitation system, conducted 3 times a week, in the clinic or in the home. First, Berg Balance Scale for balance assessment. The Performance-Oriented Mobility Assessment balance and gait subscales, and the Brunel Balance Assessment were secondary outcome measures. Clinical assessments were conducted at baseline, 8 weeks (posttreatment), and 12 weeks (follow-up). Second, the System Usability Scale and the Intrinsic Motivation Inventory for subjective experiences. Third, cost (in dollars). Significant improvement in both groups (in-clinic group [control] and a home-based telerehabilitation group) from the initial to the final assessment in the Berg Balance Scale (ηp(2)=.68; P=.001), in the balance (ηp(2)=.24; P=.006) and gait (ηp(2)=.57, P=.001) subscales of the Tinetti Performance-Oriented Mobility Assessment, and in the Brunel Balance Assessment (control: χ(2)=15.0; P=.002; experimental: χ(2)=21.9; P=.001). No significant differences were found between the groups in any balance scale or in the feedback questionnaires. With regard to subjective experiences, both groups considered the VR system similarly usable and motivating. The in-clinic intervention resulted in more expenses than did the telerehabilitation intervention ($654.72 per person). First, VR-based telerehabilitation interventions can promote the reacquisition of locomotor skills associated with balance in the same way as do in-clinic interventions, both complemented with a conventional therapy program

  7. On the Utilization of Ice Flow Models and Uncertainty Quantification to Interpret the Impact of Surface Radiation Budget Errors on Estimates of Greenland Ice Sheet Surface Mass Balance and Regional Estimates of Mass Balance

    Science.gov (United States)

    Schlegel, N.; Larour, E. Y.; Gardner, A. S.; Lang, C.; Miller, C. E.; van den Broeke, M. R.

    2016-12-01

    How Greenland ice flow may respond to future increases in surface runoff and to increases in the frequency of extreme melt events is unclear, as it requires detailed comprehension of Greenland surface climate and the ice sheet's sensitivity to associated uncertainties. With established uncertainty quantification tools run within the framework of Ice Sheet System Model (ISSM), we conduct decadal-scale forward modeling experiments to 1) quantify the spatial resolution needed to effectively force distinct components of the surface radiation budget, and subsequently surface mass balance (SMB), in various regions of the ice sheet and 2) determine the dynamic response of Greenland ice flow to variations in components of the net radiation budget. The Glacier Energy and Mass Balance (GEMB) software is a column surface model (1-D) that has recently been embedded as a module within ISSM. Using the ISSM-GEMB framework, we perform sensitivity analyses to determine how perturbations in various components of the surface radiation budget affect model output; these model experiments allow us predict where and on what spatial scale the ice sheet is likely to dynamically respond to changes in these parameters. Preliminary results suggest that SMB should be forced at at least a resolution of 23 km to properly capture dynamic ice response. In addition, Monte-Carlo style sampling analyses reveals that the areas with the largest uncertainty in mass flux are located near the equilibrium line altitude (ELA), upstream of major outlet glaciers in the North and West of the ice sheet. Sensitivity analysis indicates that these areas are also the most vulnerable on the ice sheet to persistent, far-field shifts in SMB, suggesting that continued warming, and upstream shift in the ELA, are likely to result in increased velocities, and consequentially SMB-induced thinning upstream of major outlet glaciers. Here, we extend our investigation to consider various components of the surface radiation

  8. Quality assurance in radiation processing

    International Nuclear Information System (INIS)

    Noriah Mod Ali

    2002-01-01

    The growth of the radiation processing industries in Malaysia has presented the SSDL-MINT a new set of parameter for the Quality Assurance (QA) programs. The large massive doses of radiation required for commercial application of sterilization, cross-linking etc needs measurement method outside the scope of familiar radiation detection instruments. This requires establishment of proper calibration procedure and selection of appropriate transfer system/technique to assure adequate traceability to an international radiation standard. The benefit of accurate in-plant dosimetry for the operator, approving authority and purchaser are balanced against the extra dosimetric efforts required for good QA is presented. (Author)

  9. Importance of the green color, absorption gradient, and spectral absorption of chloroplasts for the radiative energy balance of leaves.

    Science.gov (United States)

    Kume, Atsushi

    2017-05-01

    Terrestrial green plants absorb photosynthetically active radiation (PAR; 400-700 nm) but do not absorb photons evenly across the PAR waveband. The spectral absorbance of photosystems and chloroplasts is lowest for green light, which occurs within the highest irradiance waveband of direct solar radiation. We demonstrate a close relationship between this phenomenon and the safe and efficient utilization of direct solar radiation in simple biophysiological models. The effects of spectral absorptance on the photon and irradiance absorption processes are evaluated using the spectra of direct and diffuse solar radiation. The radiation absorption of a leaf arises as a consequence of the absorption of chloroplasts. The photon absorption of chloroplasts is strongly dependent on the distribution of pigment concentrations and their absorbance spectra. While chloroplast movements in response to light are important mechanisms controlling PAR absorption, they are not effective for green light because chloroplasts have the lowest spectral absorptance in the waveband. With the development of palisade tissue, the incident photons per total palisade cell surface area and the absorbed photons per chloroplast decrease. The spectral absorbance of carotenoids is effective in eliminating shortwave PAR (solar radiation. However, most of the near infrared radiation is unabsorbed and heat stress is greatly reduced. The incident solar radiation is too strong to be utilized for photosynthesis under the current CO 2 concentration in the terrestrial environment. Therefore, the photon absorption of a whole leaf is efficiently regulated by photosynthetic pigments with low spectral absorptance in the highest irradiance waveband and through a combination of pigment density distribution and leaf anatomical structures.

  10. Effects of radiational heating at low air temperature on water balance, cold tolerance, and visible injury of red spruce foliage.

    Science.gov (United States)

    Hadley, J L; Amundson, R G

    1992-07-01

    Recent studies have shown that winter needle mortality in red spruce (Picea rubens Sarg.) is increased by exposure to direct solar radiation, possibly as a result of photo-oxidative damage, accelerated winter desiccation, or reduced cold tolerance due to heating of sun-exposed needles. In an experiment at controlled subfreezing air temperatures of -10 to -20 degrees C, visible radiation was less effective than infrared radiation in producing needle desiccation and visible injury during freeze-thaw cycles. However, visible radiation produced a red-brown color in injured needles, similar to natural winter injury, whereas injured needles exposed to infrared radiation were yellow and injured needles kept in darkness were dark brown. Thus, visible radiation was necessary to produce the red-brown color of damaged needles, but not the injury itself. Needle desiccation was not strongly correlated with visible injury, but the pattern of variation in visible injury among trees and the positive correlation between electrolyte leakage and visible injury suggested that freezing damage following freeze-thaw cycles might cause the visible injury. This was confirmed by a second experiment that showed loss of cold hardiness in needles thawed by radiational heating for six consecutive days. Even with a constant nighttime temperature of -10 degrees C, six days of radiational heating of needles to above freezing caused a small (2.8 degrees C) mean decrease in needle cold tolerance, as measured by electrolyte leakage. Continuous darkness at -10 degrees C for six days resulted in an estimated 5.6 degrees C mean increase in needle cold tolerance. Freezing injury stimulated desiccation: cooling at 4 degrees C h(-1) to -43 or -48 degrees C increased the dehydration rate of isolated shoots by a factor of two to three during the first day after thawing. Within three days at 15 to 22 degrees C and 50% relative humidity, the mean water content of these shoots fell to 60% or lower, compared to

  11. Influences on the reflectance of Arctic sea ice and the impact of anthropogenic impurities on the surface shortwave radiation balance

    OpenAIRE

    Schulz, Hannes; Herber, Andreas; Birnbaum, Gerit; Seckmeyer, Gunther

    2014-01-01

    In order to investigate influences on the reflectance of snow covered Arctic sea ice, a discrete ordinate method and Mie-Theory based radiative transfer model has been set up. This model, the Snow on Sea Ice Model (SoSIM), is able to investigate changes in spectral and spectrally integrated (broadband) albedo of a multi-layer snow cover on sea ice due to varying snow microphysical parameters, atmospheric composition and incoming solar radiation. For typical conditions in the Arctic sea-ice ar...

  12. The EOS 2D/3D X-ray imaging system: a cost-effectiveness analysis quantifying the health benefits from reduced radiation exposure.

    Science.gov (United States)

    Faria, Rita; McKenna, Claire; Wade, Ros; Yang, Huiqin; Woolacott, Nerys; Sculpher, Mark

    2013-08-01

    To evaluate the cost-effectiveness of the EOS(®) 2D/3D X-ray imaging system compared with standard X-ray for the diagnosis and monitoring of orthopaedic conditions. A decision analytic model was developed to quantify the long-term costs and health outcomes, expressed as quality-adjusted life years (QALYs) from the UK health service perspective. Input parameters were obtained from medical literature, previously developed cancer models and expert advice. Threshold analysis was used to quantify the additional health benefits required, over and above those associated with radiation-induced cancers, for EOS(®) to be considered cost-effective. Standard X-ray is associated with a maximum health loss of 0.001 QALYs, approximately 0.4 of a day in full health, while the loss with EOS(®) is a maximum of 0.00015 QALYs, or 0.05 of a day in full health. On a per patient basis, EOS(®) is more expensive than standard X-ray by between £10.66 and £224.74 depending on the assumptions employed. The results suggest that EOS(®) is not cost-effective for any indication. Health benefits over and above those obtained from lower radiation would need to double for EOS to be considered cost-effective. No evidence currently exists on whether there are health benefits associated with imaging improvements from the use of EOS(®). The health benefits from radiation dose reductions are very small. Unless EOS(®) can generate additional health benefits as a consequence of the nature and quality of the image, comparative patient throughput with X-ray will be the major determinant of cost-effectiveness. Crown Copyright © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

  13. Riding the Banzai Pipeline at Jupiter: Balancing Low Delta-V and Low Radiation to Reach Europa

    Science.gov (United States)

    McElrath, Timothy P.; Campagnola, Stefano; Strange, Nathan J.

    2012-01-01

    Europa's tantalizing allure as a possible haven for life comes cloaked in a myriad of challenges for robotic spacecraft exploration. Not only are the propulsive requirements high and the solar illumination low, but the radiation environment at Jupiter administers its inexorable death sentence on any electronics dispatched to closely examine the satellite. So to the usual trades of mass, delta-V, and cost, we must add radiation dose, which tugs the trajectory solution in a contrary direction. Previous studies have concluded that adding radiation shielding mass is more efficient than using ?V to reduce the exposure time, but that position was recently challenged by a study focusing on delivering simple landers to the Europa surface. During this work, a new trajectory option was found to occupy a strategic location in the delta-V/radiation continuum - we call it the "Banzai pipeline" due to the visual similarity with the end-on view down a breaking wave, as shown in the following figures.

  14. First characterization and comparison of TEB model simulations with in situ measurements regarding radiation balance in a single urban canyon at the BOKU site (Vienna)

    Science.gov (United States)

    Oswald, Sandro; Trimmel, Heidelinde; Revesz, Michael; Nadeem, Imran; Masson, Valéry; Weihs, Philipp

    2017-04-01

    According to the World Health Organization more than half of the world population lives in a city since 2010. Predictions foresee that by 2030 six out of ten people will live in an urban area. As a result, many cities are expanding in size. Almost 10% of all urban dwellers live in megacities (defined according to UN HABITAT as a city with a population of more than 10 million). There are several effects in cities which strongly influence human health. Visible influences like the severe emissions of air pollutants by industry and traffic (e.g. Mayer H., 1999, Grimmond et al., 2010) are obvious to people but thermal stress in urban areas is only recently recognized for its strong devastating effect on human health. As a consequence, the urban environment virtually influences all weather parameters that have an impact on human comfort and thermal stress. Within this study, we investigate effects of city growth and the development of outlying districts on the local climate of Vienna. We focus particularly on the influence of urban heat island and consequent the risk for heat related illnesses or thermal stress for people. To quantify radiation balance and other important meteorological factors, we performed an extensive field campaign with three types of net radiometer in three different heights at BOKU site in August 2016. The first results indicated a strong correlation (ρ=0.96) between the Town Energy Balance (TEB) model and the measurements of the top net radiometer regarding radiation balance at roof level, meanwhile the TEB results are slightly underestimated. Further check if the measurements are reasonable, a comparison of the input values (global and direct solar radiation) for the TEB simulation with Secondary Standard measurements of ARAD site Wien Hohe Warte shows a deviation under 2% concerning interquartile range on clear sky days. The next steps will enclose TEB simulations, coupled with the mesoscale Weather Research and Forecasting (WRF) model, for

  15. Advances in radiotherapy techniques and delivery for non-small cell lung cancer: benefits of intensity-modulated radiation therapy, proton therapy, and stereotactic body radiation therapy.

    Science.gov (United States)

    Diwanji, Tejan P; Mohindra, Pranshu; Vyfhuis, Melissa; Snider, James W; Kalavagunta, Chaitanya; Mossahebi, Sina; Yu, Jen; Feigenberg, Steven; Badiyan, Shahed N

    2017-04-01

    The 21st century has seen several paradigm shifts in the treatment of non-small cell lung cancer (NSCLC) in early-stage inoperable disease, definitive locally advanced disease, and the postoperative setting. A key driver in improvement of local disease control has been the significant evolution of radiation therapy techniques in the last three decades, allowing for delivery of definitive radiation doses while limiting exposure of normal tissues. For patients with locally-advanced NSCLC, the advent of volumetric imaging techniques has allowed a shift from 2-dimensional approaches to 3-dimensional conformal radiation therapy (3DCRT). The next generation of 3DCRT, intensity-modulated radiation therapy and volumetric-modulated arc therapy (VMAT), have enabled even more conformal radiation delivery. Clinical evidence has shown that this can improve the quality of life for patients undergoing definitive management of lung cancer. In the early-stage setting, conventional fractionation led to poor outcomes. Evaluation of altered dose fractionation with the previously noted technology advances led to advent of stereotactic body radiation therapy (SBRT). This technique has dramatically improved local control and expanded treatment options for inoperable, early-stage patients. The recent development of proton therapy has opened new avenues for improving conformity and the therapeutic ratio. Evolution of newer proton therapy techniques, such as pencil-beam scanning (PBS), could improve tolerability and possibly allow reexamination of dose escalation. These new progresses, along with significant advances in systemic therapies, have improved survival for lung cancer patients across the spectrum of non-metastatic disease. They have also brought to light new challenges and avenues for further research and improvement.

  16. Role of homeostatic dis balance in formation of the late consequences for radiation exposure in Kazakhstan population

    International Nuclear Information System (INIS)

    Galich, B.V.; Belikhina, T.I.; Moldagaliev, T.Zh.; Tretyakova, E.B.

    2008-01-01

    The purpose of research is to study localizations and level of homeostatic disturbances in the key organism systems forming the social important illness for the realization of State and regional rehabilitation programs in the Kazakhstan population exposed to radiation and non-radiation risk factors. The object of research was the data of medical examinations in the exposed population living in Abaisky, Beskaragaisky, Zhanasemejsky districts of East-Kazakhstan area for the period from 1962 to 2006 in three time intervals: 1962-1966; 1968-1987; 2002-2006. The control data was the results of medical examination of the population of Shadrinskoe village of Pavlodar area and Kokpekty village of East-Kazakhstan area for the same time period. We have studied two dose groups: 1 group of exposed population (dose 0,5 > Sv); II group of exposed population (dose 0,2-0,25 Sv). Study of dynamics for prevalence of cardiovascular and gastrointestinal diseases connected with damage in haemopoietic, immune and vegetative homeostasis was carried out in 987 exposed persons and persons included to control group.

  17. Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives

    International Nuclear Information System (INIS)

    Haydont, Valerie; Mathe, Denis; Bourgier, Celine; Abdelali, Jalil; Aigueperse, Jocelyne; Bourhis, Jean; Vozenin-Brotons, Marie-Catherine

    2005-01-01

    Background and purpose: Transforming Growth Factor β1 (TGF-β1) and its downstream effector Connective Tissue Growth Factor (CTGF/CCN2), are well known fibrogenic activators and we previously showed that the Rho/ROCK pathway controls CTGF expression in intestinal smooth muscle cells isolated from patients with delayed radiation enteritis. The aim of the present work was to investigate the balance between Smad and Rho signalling pathways in the TGF-β1 CTGF induction and modulation of radiation-induced fibrogenic differentiation after addition of pravastatin, an inhibitor of Rho isoprenylation. Patients and methods: Primary human smooth muscle cells isolated from normal (N-SMC) or radiation enteritis (RE-SMC) biopsies were incubated with TGF-β1 (10 ng/ml). Induction of CTGF, as well as nucleo-cytoplasmic distribution of phospho-Smad2/3, Smad2/3 and Smad4 were analysed by Western blot and immunocytochemistry. Smad DNA binding was assessed by EMSA and Rho activation was measured by pull-down assay. Results: After TGF-β1 addition, Smads were translocated to the nucleus in both cell types. Nuclear accumulation of Smad as well as their DNA-binding activity were higher in N-SMC than in RE-SMC, whereas the opposite was observed for Rho activation, suggesting a main involvement of Rho pathway in sustained fibrogenic differentiation. This hypothesis was further supported by the antifibrotic effect observed in vitro after cell treatment with pravastatin (i.e. decreased expression of CTGF, TGF-β1 and Collagen Iα2). Conclusions: Our results suggest that TGF-β1-induced CTGF transactivation mainly depends on the Smad pathway in N-SMC, whereas in RE-SMC, Smad and Rho pathways are involved. Inhibition of Rho activity by pravastatin alters fibrogenic differentiation in vitro which opens up new therapeutic perspectives

  18. Climate studies from satellite observations - Special problems in the verification of earth radiation balance, cloud climatology, and related climate experiments

    Science.gov (United States)

    Vonder Haar, T. H.

    1982-01-01

    A body of techniques that have been developed and planned for use during the Earth Radiation Budget Experiment (ERBE), the International Satellite Cloud Climatology Project (ISCCP), and related climate experiments of the 1980's are reviewed. Validation and verification methods must apply for systems of satellites. They include: (1) use of a normalization or intercalibration satellite, (2) special intensive observation areas located over ground-truth sites, and (3) monitoring of sun and earth by several satellites and/or several instruments at the same time. Since each climate application area has a hierarchy of user communities, validation techniques vary from very detailed methods to those that simply assure high relative accuracy in detecting space and time variations for climate studies. It is shown that climate experiments generally require more emphasis on long-term stability and internal consistency of satellite data sets than high absolute accuracy.

  19. Effect of drink pattern and solar radiation on thermoregulation and fluid balance during exercise in chronically heat acclimatized children.

    Science.gov (United States)

    Santana, José R Rodríguez; Rivera-Brown, Anita M; Frontera, Walter R; Rivera, Miguel A; Mayol, Pedro M; Bar-Or, Oded

    1995-01-01

    The purposes of this study were to examine the thermoregulatory and body fluid balance responses in chronically heat acclimatized children, i.e., indigenous to a tropical climate, during exercise in four outdoor conditions and the effects of dehydration on their thermoregulatory response. Nine children (age = 13.3 ± 1.9 yr, VO 2 max = 45.5 ± 9.2 ml · kg -1 · min -1 ) cycled at 60% VO 2 max each under four conditions: sun exposure voluntary drinking (SuVD), sun exposure forced drinking (SuFD), shaded voluntary drinking (ShVD), and shaded forced drinking (ShFD). Exercise sessions consisted of four 20-min exercise bouts alternating with 25-min rest periods. Globe temperature and the WBGT index were higher during SuVD and SuFD compared to ShVD and ShFD (P dehydration and adequate heat dissipation. © 1995 Wiley-Liss, Inc. Copyright © 1995 Wiley-Liss, Inc., A Wiley Company.

  20. TARGETED AND OFF-TARGET (BYSTANDER AND ABSCOPAL) EFFECTS OF RADIATION THERAPY: REDOX MECHANISMS AND RISK-BENEFIT ANALYSIS.

    Science.gov (United States)

    Pouget, Jean-Pierre; Georgakilas, Alexandros G; Ravanat, Jean-Luc

    2018-01-19

    Radiation therapy (from external beams to unsealed and sealed radionuclide sources) takes advantage of the detrimental effects of the clustered production of radicals and reactive oxygen species (ROS). Research has mainly focused on the interaction of radiation with water, which is the major constituent of living beings, and with nuclear DNA, which contains the genetic information. This led to the so-called "target" theory according to which cells have to be hit by ionizing particles to elicit an important biological response, including cell death. In cancer therapy, the Poisson law and linear quadratic mathematical models have been used to describe the probability of hits per cell as a function of the radiation dose. However, in the last twenty years, many studies have shown that radiation generates "danger" signals that propagate from irradiated to non-irradiated cells, leading to bystander and other off-target effects. Like for targeted effects, redox mechanisms play a key role also in off-target effects through transmission of ROS and reactive nitrogen species (RNS), but also of cytokines, ATP and extracellular DNA. Particularly, nuclear factor kappa B is essential for triggering self-sustained production of ROS and RNS, thus making the bystander response similar to inflammation. In some therapeutic situations, this phenomenon is associated with recruitment of immune cells that are involved in distant irradiation effects (called "away-from-target" i.e. abscopal effects). Determining the contribution of targeted and off-target effects in the clinic is still challenging. This has important consequences in radiotherapy, but also possibly in diagnostic procedures and in radiation protection.

  1. Which benefits and harms of preoperative radiotherapy should be addressed? A Delphi consensus study among rectal cancer patients and radiation oncologists

    International Nuclear Information System (INIS)

    Kunneman, Marleen; Pieterse, Arwen H.; Stiggelbout, Anne M.; Marijnen, Corrie A.M.

    2015-01-01

    Background and purpose: We previously found considerable variation in information provision on preoperative radiotherapy (PRT) in rectal cancer. Our aims were to reach consensus among patients and oncologists on which benefits/harms of PRT should be addressed during the consultation, and to assess congruence with daily clinical practice. Materials and methods: A four-round Delphi-study was conducted with two expert panels: (1) 31 treated rectal cancer patients and (2) 35 radiation oncologists. Thirty-seven possible benefits/harms were shown. Participants indicated whether addressing the benefit/harm was (1) essential, (2) desired, (3) not necessary, or (4) to be avoided. Consensus was assumed when ⩾80% of the panel agreed. Results were compared to 81 audio-taped consultations. Results: The panels reached consensus that six topics should be addressed in all patients (local control, survival, long term altered defecation pattern and faecal incontinence, perineal wound healing problems, advice to avoid pregnancy), three in male patients (erectile dysfunction, ejaculation disorder, infertility), and four in female patients (vaginal dryness, pain during intercourse, menopause, infertility). On average, less than half of these topics were addressed in daily clinical practice. Conclusions: This study showed substantial overlap between benefits/harms that patients and oncologists consider important to address during the consultation, and at the same time poor congruence with daily clinical practice

  2. Which benefits and harms of preoperative radiotherapy should be addressed? A Delphi consensus study among rectal cancer patients and radiation oncologists.

    Science.gov (United States)

    Kunneman, Marleen; Pieterse, Arwen H; Stiggelbout, Anne M; Marijnen, Corrie A M

    2015-02-01

    We previously found considerable variation in information provision on preoperative radiotherapy (PRT) in rectal cancer. Our aims were to reach consensus among patients and oncologists on which benefits/harms of PRT should be addressed during the consultation, and to assess congruence with daily clinical practice. A four-round Delphi-study was conducted with two expert panels: (1) 31 treated rectal cancer patients and (2) 35 radiation oncologists. Thirty-seven possible benefits/harms were shown. Participants indicated whether addressing the benefit/harm was (1) essential, (2) desired, (3) not necessary, or (4) to be avoided. Consensus was assumed when ⩾80% of the panel agreed. Results were compared to 81 audio-taped consultations. The panels reached consensus that six topics should be addressed in all patients (local control, survival, long term altered defecation pattern and faecal incontinence, perineal wound healing problems, advice to avoid pregnancy), three in male patients (erectile dysfunction, ejaculation disorder, infertility), and four in female patients (vaginal dryness, pain during intercourse, menopause, infertility). On average, less than half of these topics were addressed in daily clinical practice. This study showed substantial overlap between benefits/harms that patients and oncologists consider important to address during the consultation, and at the same time poor congruence with daily clinical practice. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  3. Radiation balance in a soybean ecosystem in the Amazon Balanço de radiação em ecossistema de soja na Amazônia

    Directory of Open Access Journals (Sweden)

    Paulo Jorge de Oliveira Ponte de Souza

    2010-12-01

    Full Text Available The continuous advance of the agricultural border in the Amazon has been worrying the scientific community due to the possible environmental impacts caused by this change in land use. The present work evaluated the behavior of the radiation balance components over the soybean crop (Glycine Max (L. Merryl in an Amazon area of continuous advance of the agricultural border. The radiation components were continuously monitored during the soybean cycle in 2006 and 2007 in an area of 200 ha. The soybean cultivation in the Amazon presented an abrupt change in the radiation balance components, with the consequent reduction in the energy available to the environment due to the increase in the surface reflection. There was a significant contribution of the diffuse radiation component in the soybean interception during cloudy conditions, even under incomplete canopy covering. Moreover, after the canopy closure, a similar interaction between soybean and solar radiation occurs, regardless of the cloud condition.O avanço da fronteira agrícola na Amazônia, da forma como vem sendo realizado, tem deixado a comunidade cada vez mais preocupada ante os possíveis impactos ambientais decorrentes desta mudança no uso da terra, devido à grande importância que a Amazônia representa para o clima global. Neste trabalho avaliaram-se os componentes do balanço de radiação à superfície, ao longo do ciclo da soja (Glycine Max (L. Merryl, em uma área de avanço da fronteira agrícola na Amazônia. Os componentes do balanço de radiação foram monitorados continuamente durante o ciclo da soja, em 2006 e 2007, em uma área de 200 ha de extensão. O monocultivo da soja na Amazônia apresentou uma contínua mudança nos componentes do balanço de radiação, tendo como consequência uma redução na energia disponível para o ambiente devido o aumento na reflexão da superfície. Observou-se uma importante contribuição da radiação solar difusa na intercepta

  4. Balance Problems

    Science.gov (United States)

    ... often, it could be a sign of a balance problem. Balance problems can make you feel unsteady. You may ... related injuries, such as a hip fracture. Some balance problems are due to problems in the inner ...

  5. Noncontrast chest computed tomography immediately after transarterial chemoembolization in patients with hepatocellular carcinoma: clinical benefits and effect of radiation reduction on image quality in low-dose scanning.

    Science.gov (United States)

    Choi, Joon-Il; Kim, Hyun Beom; Kim, Min Ju; Lee, Jong Seok; Koh, Young Whan; An, Sang Bu; Ko, Heung-kyu; Park, Joong-Won

    2011-11-01

    To evaluate the clinical benefits of noncontrast chest computed tomography (CT) immediately after transarterial chemoembolization in patients with hepatocellular carcinoma and to assess the effect of radiation reduction on image quality in low-dose scanning. From June to October 2010, we performed standard-dose, noncontrast chest CTs immediately after transarterial chemoembolization in 160 patients and low-dose CTs in 88 patients. We reviewed the entire noncontrast chest CTs and follow-up CTs to reveal the clinical benefits of CT evaluation immediately after transarterial chemoembolization. Using two independent readers, we also retrospectively evaluated the radiation dose and image quality in terms of the image noise, contrast between the liver parenchyma and iodized oil and diagnostic acceptability for the evaluation of treatment response after transarterial chemoembolization. In 5.2% of the patients, additional treatment was performed immediately after the interpretation of the noncontrast chest CT, and additional pulmonary lesions were found in 8.5% of the patients. The measured mean dose-length product for the low-dose scanning was 18.4% of that of the standard-dose scanning. The image noise was significantly higher with the low-dose scanning (pbenefits for immediate decision making and detecting pulmonary lesions. Low-dose, noncontrast chest CTs immediately after transarterial chemoembolization consistently provide diagnostically acceptable images and information on treatment response in patients who have undergone transarterial chemoembolization. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  6. A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits

    Science.gov (United States)

    Marum, Ana Paula; Moreira, Cátia; Tomas-Carus, Pablo; Saraiva, Fernando; Guerreiro, Catarina Sousa

    2017-06-05

    Fibromyalgia is a chronic rheumatic disease producing widespread pain, associated to a major comorbidity -irritable bowel syndrome. Low FODMAPS diet (low fermentable oligo-di-mono-saccharides and polyols diet) has been effective in controlling irritable bowel syndrome symptoms. Overweight is an aggravating factor for fibromyalgia. We studied effects of low fermentable oligo-di-mono-saccharides and polyols diets on fibromyalgia symptoms and weight status. A longitudinal study was performed on 38 fibromyalgia patients using a four-week, repeated assessment as follow: M1 = first assessments/presentation of individual low fermentable oligo-di-mono-saccharides and polyols diet; M2 = second assessments/reintroduction of FODMAPs; M3 = final assessments/nutritional counselling. The assessment instruments applied were: Fibromyalgia Survey Questionnaire (FSQ); Severity Score System (IBS-SSS); visual analogic scale (VAS). Body mass-index/composition and waist circumference (WC) were also measured. Daily macro-micronutrients and FODMAP intake were quantified at each moment of the study. The studied cohort was 37% overweight, 34% obese (average body mass-index 27.4 ± 4.6; excess fat mass 39.4 ± 7%). Weight, body mass-index and waist circumference decreased significantly (p diet, but no significant effect on body composition was observed. All fibromyalgiasymptoms, including somatic pain, declined significantly post-LFD (p Diet adherence" (85%). "Satisfaction with improvement of symptoms" (76%), showed correlating with "diet adherence" (r = 0.65; p diets as a nutritionally balanced approach, contributing to weight loss and reducing the severity of FM fibromyalgiasymptoms.

  7. Radiation

    International Nuclear Information System (INIS)

    Davidson, J.H.

    1986-01-01

    The basic facts about radiation are explained, along with some simple and natural ways of combating its ill-effects, based on ancient healing wisdom as well as the latest biochemical and technological research. Details are also given of the diet that saved thousands of lives in Nagasaki after the Atomic bomb attack. Special comment is made on the use of radiation for food processing. (U.K.)

  8. Contrast-enhanced spectral mammography: Does mammography provide additional clinical benefits or can some radiation exposure be avoided?

    Science.gov (United States)

    Fallenberg, Eva Maria; Dromain, Clarisse; Diekmann, Felix; Renz, Diane M; Amer, Heba; Ingold-Heppner, Barbara; Neumann, Avidan U; Winzer, Klaus J; Bick, Ulrich; Hamm, Bernd; Engelken, Florian

    2014-07-01

    The purpose of this study was to compare contrast-enhanced spectral mammography (CESM) with mammography (MG) and combined CESM + MG in terms of detection and size estimation of histologically proven breast cancers in order to assess the potential to reduce radiation exposure. A total of 118 patients underwent MG and CESM and had final histological results. CESM was performed as a bilateral examination starting 2 min after injection of iodinated contrast medium. Three independent blinded radiologists read the CESM, MG, and CESM + MG images with an interval of at least 4 weeks to avoid case memorization. Sensitivity and size measurement correlation and differences were calculated, average glandular dose (AGD) levels were compared, and breast densities were reported. Fisher's exact and Wilcoxon tests were performed. A total of 107 imaging pairs were available for analysis. Densities were ACR1: 2, ACR2: 45, ACR3: 42, and ACR4: 18. Mean AGD was 1.89 mGy for CESM alone, 1.78 mGy for MG, and 3.67 mGy for the combination. In very dense breasts, AGD of CESM was significantly lower than MG. Sensitivity across readers was 77.9 % for MG alone, 94.7 % for CESM, and 95 % for CESM + MG. Average tumor size measurement error compared to postsurgical pathology was -0.6 mm for MG, +0.6 mm for CESM, and +4.5 mm for CESM + MG (p radiation dose, especially in patients with dense breasts.

  9. Benefits of inferential statistical methods in radiation exposure studies: another look at percutaneous spinal cord stimulation mapping [trialing] procedures.

    Science.gov (United States)

    Wininger, Kevin L

    2012-01-01

    Two studies, each consisting of large sample sets, were recently published on radiation exposure in percutaneous spinal cord stimulation (SCS) trialing procedures. A more rigorous use of statistical methods in the second study more accurately defined benchmark reference levels. Principally, one physician implanter-considered an advanced interventional pain physician-performed all such procedures to nullify inter-physician variability. However, the literature is sparse in articles comparing exposure levels of radiation in pain procedures conducted by novice and advanced interventionally trained physicians, and inferential statistical analysis is seldom included in radiation exposure studies. The aim of this study was to compare fluoroscopy times between novice and expert physician implanters performing SCS trialing procedures, and to the benchmarked reference level, using inferential statistical methods. As a secondary objective, the importance of statistical concepts in interpretive-imaging and image guidance studies for interventional pain procedures will be outlined. An observational study. A non-university outpatient Interventional Pain Management practice in the United States. Fluoroscopy time (in seconds) was retrospectively studied in 18 SCS trialing procedures (with dual lead placement in the low thoracic spine) performed over a 3-month period. The procedures were categorized by physician experience: one novice physician implanter with n = 5 cases and one expert physician implanter with n = 13 cases. All procedures were conducted with the same fluoroscope operator and the same mobile C-arm fluoroscopy system. A two-tailed t-test was used to compare mean fluoroscopy times between physician categories. Left-tailed t-tests were used to compare mean fluoroscopy times for each physician category separately to the benchmark level (μ = 71.7 seconds). Incident air kerma (KERMA) was assessed by nonsimplistic modeling. No statistical difference was found in mean

  10. The National Radiation Protection Authority and its regulatory programme. Potential benefits of the CTBT and thoughts on cooperation

    International Nuclear Information System (INIS)

    Gebeyehu, G.

    1999-01-01

    In the past years Ethiopia became an active participant in the scientific and political development as well as supporter of the CTBT. This paper describes the designated institution for the CTBT implementation in the area of Radionuclides in Ethiopia and its scientific and regulatory program as well as main activities concerning application techniques. The second part of the paper accounts for the links between the objectives of the national institute with the CTBT. It draws substantive details about benefits that could arise from participating in CTBT implementation and summarizes the discussion by suggesting modalities for building partnership and cooperation

  11. The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance.

    Science.gov (United States)

    Costa, Sara; Afonso, Cláudia; Bandarra, Narcisa Maria; Gueifão, Sandra; Castanheira, Isabel; Carvalho, Maria Luísa; Cardoso, Carlos; Nunes, Maria Leonor

    2013-10-01

    The effect of cooking methods (boiling, grilling, and roasting) on the proximate and mineral composition, contaminants concentration and fatty acids profile was evaluated aiming to understand the benefits and risks associated to the consumption of the emerging farmed fish meagre (Argyrosomus regius). All the treatments led to lower moisture content. After grilling and roasting, the SFA, MUFA and PUFA contents increased. There was no degradation of EPA and DHA during the culinary processes. Significant retention of minerals in grilled and roasted meagre samples was registered. For Pb and Cd there were no concentration differences between culinary treatments and regarding raw fish. Whereas As level was higher in grilled meagre, total Hg and Me-Hg values were augmented in grilled and roasted meagre. The consumption of meagre is advisable due to the low and healthy fat, high selenium and protein content. Grilling would be the best culinary treatment due to the retention of protein, EPA, DHA and minerals. But as the risk of ingestion of Me-Hg content also increases, based on the risk assessment, intake should not exceed two weekly meals, provided that no other important Me-Hg food source is present in the diet. Otherwise, even this maximum threshold should be lower. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Transport of pollution to a remote coastal site during gap flow from California's interior: impacts on aerosol composition, clouds, and radiative balance

    Science.gov (United States)

    Martin, Andrew C.; Cornwell, Gavin C.; Atwood, Samuel A.; Moore, Kathryn A.; Rothfuss, Nicholas E.; Taylor, Hans; DeMott, Paul J.; Kreidenweis, Sonia M.; Petters, Markus D.; Prather, Kimberly A.

    2017-01-01

    During the CalWater 2015 field campaign, ground-level observations of aerosol size, concentration, chemical composition, and cloud activity were made at Bodega Bay, CA, on the remote California coast. A strong anthropogenic influence on air quality, aerosol physicochemical properties, and cloud activity was observed at Bodega Bay during periods with special weather conditions, known as Petaluma Gap flow, in which air from California's interior is transported to the coast. This study applies a diverse set of chemical, cloud microphysical, and meteorological measurements to the Petaluma Gap flow phenomenon for the first time. It is demonstrated that the sudden and often dramatic change in aerosol properties is strongly related to regional meteorology and anthropogenically influenced chemical processes in California's Central Valley. In addition, it is demonstrated that the change in air mass properties from those typical of a remote marine environment to properties of a continental regime has the potential to impact atmospheric radiative balance and cloud formation in ways that must be accounted for in regional climate simulations.

  13. Helical tomotherapy provides efficacy similar to that of intensity-modulated radiation therapy with dosimetric benefits for endometrial carcinoma

    Directory of Open Access Journals (Sweden)

    Hsieh CH

    2012-10-01

    Full Text Available Chen-Hsi Hsieh,1,4–6 Pei-Wei Shueng,1,3 Sheng-Mou Hsiao,2 Ming-Chow Wei,2 Wen-Yih Wu,2 Hsu-Dong Sun,2 Hui-Ju Tien,1 Li-Ying Wang,7 Yen-Ping Hsieh81Division of Radiation Oncology, Department of Radiology, 2Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, 3Department of Radiation Oncology, National Defense Medical Center, 4Department of Medicine, 5Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, 6Oriental Institute of Technology, New Taipei City, 7School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, 8Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung, Taiwan, ChinaBackground: The purpose of this study was to compare the efficacy of intensity-modulated radiotherapy (IMRT and helical tomotherapy for endometrial cancer.Methods: Between November 1, 2006 and November 31, 2010, 31 patients with histologically confirmed endometrial cancer were enrolled. All enrolled patients received total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant whole pelvic IMRT or helical tomotherapy.Results: The actuarial 3-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates for the IMRT and helical tomotherapy groups were 87.5% versus 100%, 91.7% versus 51.7%, 91.7% versus 83.3%, and 91.7% versus 51.7%, respectively. The conformal index and uniformity index for IMRT versus helical tomotherapy was 1.25 versus 1.17 (P = 0.04 and 1.08 versus 1.05 (P < 0.01, respectively. Two of 31 patients with cervical stump failure were noted, one in the IMRT group and the other in the helical tomotherapy group. No acute or late grade 3 or 4 toxicities were noted, including proctitis, or genitourinary or gastrointestinal disturbances.Conclusion: Helical tomotherapy is as effective as IMRT and has better uniformity and

  14. The benefits of folic acid-modified gold nanoparticles in CT-based molecular imaging: radiation dose reduction and image contrast enhancement.

    Science.gov (United States)

    Beik, Jaber; Jafariyan, Maryam; Montazerabadi, Alireza; Ghadimi-Daresajini, Ali; Tarighi, Parastoo; Mahmoudabadi, Alireza; Ghaznavi, Habib; Shakeri-Zadeh, Ali

    2017-12-12

    X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high image quality is an important requirement in CT, the radiation dose must be kept minimal to protect the patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition of cancer cells may be one of the balanced solutions. Herein, we report the effect of folic acid (FA)-modified AuNP as a targeted nanoprobe on the contrast enhancement of CT images as well as its potential for patient dose reduction. For this purpose, nasopharyngeal KB cancer cells overexpressing FA receptors were incubated with AuNPs with and without FA modification and imaged in a CT scanner with the following X-ray tube parameters: peak tube voltage of 130 KVp, and tube current-time products of 60, 90, 120, 160 and 250 mAs. Moreover, in order to estimate the radiation dose to which the patient was exposed during a head CT protocol, the CT dose index (CTDI) value was measured by an X-ray electrometer by changing the tube current-time product. Raising the tube current-time product from 60 to 250 mAs significantly increased the absorbed dose from 18 mGy to 75 mGy. This increase was not associated with a significant enhancement of the image quality of the KB cells. However, an obvious increase in image brightness and CT signal intensity (quantified by Hounsfield units [HU]) were observed in cells exposed to nanoparticles without any increase in the mAs product or radiation dose. Under the same Au concentration, KB cells exposed to FA-modified AuNPs had significantly higher HU and brighter CT images than those of the cells exposed to AuNPs without FA modification. In conclusion, FA-modified AuNP can be considered as a targeted CT nanoprobe with the potential for dose reduction by keeping the required mAs product as low as possible while enhancing image contrast.

  15. The Benefits of Prone SPECT Myocardial Perfusion Imaging in Reducing Both Artifact Defects and Patient Radiation Exposure.

    Science.gov (United States)

    Stathaki, Maria; Koukouraki, Sophia; Papadaki, Emmanouela; Tsaroucha, Angeliki; Karkavitsas, Nikolaos

    2015-10-01

    Prone imaging has been demonstrated to minimize diaphragmatic and breast tissue attenuation. To determine the role of prone imaging on the reduction of unnecessary rest perfusion studies and coronary angiographies performed, thus decreasing investigation time and radiation exposure. We examined 139 patients, 120 with an inferior wall and 19 with an anterior wall perfusion defect that might represented attenuation artifact. Post-stress images were acquired in both the supine and prone position. Coronary angiography was used as the "gold standard" for evaluating coronary artery patency. The study was terminated and rest imaging was obviated in the presence of complete improvement of the defect in the prone position. Quantitative interpretation was performed. Results were compared with clinical data and coronary angiographic findings. Prone acquisition correctly revealed defect improvement in 89 patients (89/120) with inferior wall and 12 patients (12/19) with anterior wall attenuation artifact. Quantitative analysis demonstrated statistically significant difference in the mean summed stress scores (SSS) of supine and mean SSS of prone studies in patients with disappearing inferior wall defect in the prone position and patent right coronary artery (true negative results). The mean difference between SSS in supine and in prone position was higher with disappearing than with remaining defects. Technetium-99m (Tc-99m) tetrofosmin myocardial perfusion imaging with the patient in the prone position overcomes soft tissue attenuation; moreover it provides an inexpensive, accurate approach to limit the number of unnecessary rest perfusion studies and coronary angiographies performed.

  16. The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy.

    Science.gov (United States)

    Lo, Victor C K; Akens, Margarete K; Wise-Milestone, Lisa; Yee, Albert J M; Wilson, Brian C; Whyne, Cari M

    2013-09-01

    Photodynamic therapy (PDT) has been shown to ablate tumors within vertebral bone and yield short-term improvements in vertebral architecture and biomechanical strength, in particular when combined with bisphosphonate (BP) treatment. Longer-term outcomes of PDT combined with current treatments for skeletal metastases are essential to understand its therapeutic potential. The objective of this study is to evaluate the response of vertebrae to PDT after a longer (6-week) time period, alone and combined with previous BP or radiation treatment (RT). Sixty-three female rnu/rnu rats were randomized to six treatment groups: untreated control, BP-only, RT-only, PDT-only, combined BP + PDT and combined RT + PDT. L2 vertebrae were structurally analyzed through µCT-based analysis, axial compressive load-to-failure testing and histological analysis of morphology, osteoid formation and osteoclast activity. Combined BP + PDT treatment yielded the largest improvements in bone architecture with combined RT + PDT treatment yielding similar findings, but of a lesser magnitude. Mechanically, ultimate force and stress were correlated to stereological parameters that demonstrated a positive structural effect from combinatory treatment. Increased osteoid formation was observed in both combination therapies without any significant differences in osteoclast activity. Overall, multimodality treatment demonstrated a sustained positive effect on vertebral structural integrity, motivating PDT as a minimally-invasive adjuvant treatment for spinal metastases. Copyright © 2013 Orthopaedic Research Society.

  17. HPV Genotypes Predict Survival Benefits From Concurrent Chemotherapy and Radiation Therapy in Advanced Squamous Cell Carcinoma of the Cervix

    International Nuclear Information System (INIS)

    Wang, Chun-Chieh; Lai, Chyong-Huey; Huang, Yi-Ting; Chao, Angel; Chou, Hung-Hsueh; Hong, Ji-Hong

    2012-01-01

    Purpose: To study the prognostic value of human papillomavirus (HPV) genotypes in patients with advanced cervical cancer treated with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). Methods and Materials: Between August 1993 and May 2000, 327 patients with advanced squamous cell carcinoma of the cervix (International Federation of Gynecology and Obstetrics stage III/IVA or stage IIB with positive lymph nodes) were eligible for this study. HPV genotypes were determined using the Easychip® HPV genechip. Outcomes were analyzed using Kaplan-Meier survival analysis and the Cox proportional hazards model. Results: We detected 22 HPV genotypes in 323 (98.8%) patients. The leading 4 types were HPV16, 58, 18, and 33. The 5-year overall and disease-specific survival estimates for the entire cohort were 41.9% and 51.4%, respectively. CCRT improved the 5-year disease-specific survival by an absolute 9.8%, but this was not statistically significant (P=.089). There was a significant improvement in disease-specific survival in the CCRT group for HPV18-positive (60.9% vs 30.4%, P=.019) and HPV58-positive (69.3% vs 48.9%, P=.026) patients compared with the RT alone group. In contrast, the differences in survival with CCRT compared with RT alone in the HPV16-positive and HPV-33 positive subgroups were not statistically significant (P=.86 and P=.53, respectively). An improved disease-specific survival was observed for CCRT treated patients infected with both HPV16 and HPV18, but these differenced also were not statistically significant. Conclusions: The HPV genotype may be a useful predictive factor for the effect of CCRT in patients with advanced squamous cell carcinoma of the cervix. Verifying these results in prospective trials could have an impact on tailoring future treatment based on HPV genotype.

  18. Dosimetric benefits of placing dose constraints on the brachial plexus in patients with nasopharyngeal carcinoma receiving intensity-modulated radiation therapy: a comparative study.

    Science.gov (United States)

    Jiang, Hailan; Lu, Heming; Yuan, Hong; Huang, Huixian; Wei, Yinglin; Zhang, Yanxian; Liu, Xu

    2015-01-01

    This study aimed to evaluate whether placing dose constraints on the brachial plexus (BP) could provide dosimetric benefits in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy (IMRT). Planning CT images for 30 patients with NPC treated with definitive IMRT were retrospectively reviewed. Target volumes, the BP and other critical structures were delineated; two separate IMRT plans were designed for each patient: one set no restrictions for the BP; the other considered the BP as a critical structure for which a maximum dose limit of ≤66 Gy was set. No significant differences between the two plans were observed in the conformity index, homogeneity index, maximum dose to the planning target volumes (PTVs), minimum dose to the PTVs, percentages of the volume of the PTVnx and PTVnd receiving more than 110% of the prescribed dose, or percentages of the volume of the PTVs receiving 95% and > 93% of the prescribed dose. Dose constraints significantly reduced the maximum dose, mean dose, V45, V50, V54, V60, V66 and V70 to the BP. Dose constraints significantly reduced the maximum dose to the BP, V45, V60 and V66 in both N0-1 and N2-3 disease; however, the magnitude of the dosimetric gain for each parameter between N0-1 and N2-3 disease was not significantly different, except for the V60 and V66. In conclusion, placing dose constraints on the BP can significantly decrease the irradiated volume and dose, without compromising adequate dose delivery to the target volume. © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  19. Balancing Acts

    Science.gov (United States)

    ... Past Issues Special Section: Focus on Communication Balancing Acts Past Issues / Fall 2008 Table of Contents For ... scientific research on hearing, balance, smell, taste, voice, speech, and language—common elements in how we perceive ...

  20. Radiation risks: critical analysis and commentary.

    Science.gov (United States)

    Barrett, Bruce; Stiles, Melissa; Patterson, Jeff

    2012-01-01

    1) To review and summarize what is known about the health risks of radiation. 2) To compare risks from medical imaging to background radiation and to exposure from nuclear accidents. Literature review and summative critical analysis. Over the past several years, physicians and patients have become increasingly aware of the potential risks of radiation exposure from medical imaging. The Fukushima disaster further heightened public awareness of hazards associated with radiation and radioactivity. In the case of medical imaging, small but real risks of cancer and other radiation-induced disease must be balanced against potential benefits of improved diagnostic accuracy. The ethical principle of autonomy tells us that patients should be informed of potential benefits and harms of radiation imaging, and should participate in shared decision making. In the case of nuclear power, benefits and especially harms are exceptionally difficult to estimate accurately. Nevertheless, we know that hazards from today's nuclear power plants will persist for many years, affecting future generations not benefiting from electrical power generated today. A deeper and more widespread understanding of potential benefits and harms of personal and societal choices relating to radiation exposure may lead to improved medical and societal decision-making. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. Lack of Apparent Survival Benefit With Use of Androgen Deprivation Therapy in Patients With High-risk Prostate Cancer Receiving Combined External Beam Radiation Therapy and Brachytherapy.

    Science.gov (United States)

    Yang, David D; Muralidhar, Vinayak; Mahal, Brandon A; Nguyen, Paul L; Devlin, Phillip M; King, Martin T; Orio, Peter F

    2018-01-01

    Although level 1 evidence has demonstrated a survival benefit from the addition of androgen deprivation therapy (ADT) to external beam radiation therapy (EBRT) for patients with high-risk prostate cancer, the benefits of ADT with combined EBRT and brachytherapy for high-risk patients are unclear. We examined the association between ADT and overall survival in a national cohort of high-risk patients treated with EBRT with or without brachytherapy. We identified 46,325 men in the National Cancer Database with a diagnosis of high-risk prostate cancer (Gleason score 8-10, clinical stage T3-T4, or prostate-specific antigen >20 ng/mL) who were treated with EBRT with or without brachytherapy and ADT from 2004 through 2011. Multivariable Cox regression analysis adjusting for sociodemographic and clinicopathologic factors was used to identify the association between ADT and overall survival. The median follow-up period was 48.6 and 59.2 months for patients treated with EBRT only and combined modality RT, respectively. ADT was associated with an improvement in overall survival for the 85.0% (39,361) of the study cohort who underwent EBRT alone (adjusted hazard ratio 0.91, P=.001) but not for patients treated with combined modality RT (adjusted hazard ratio 1.05, P=.496), with a significant interaction (P interaction =.036). In contrast to the known survival benefit when ADT is given with EBRT, our results suggest that ADT might not improve survival for high-risk patients who undergo combined EBRT and brachytherapy. Given the significant adverse effects of ADT, in particular, with long-term therapy, a randomized controlled trial of combined EBRT and brachytherapy with or without ADT for select high-risk patients using a noninferiority design should be undertaken. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Radiation. A buzz word for excessive fears

    International Nuclear Information System (INIS)

    Rickover, H.G.

    1980-01-01

    The necessity of accepting that risk is an inherent part of daily life and also of acquiring a sense of perspective with respect to such risks, especially with respect to radiation, is discussed. Estimations of radiation risks are examined and compared to other risk factors such as overweight and cigarette smoking. It is stated that public perception of radiation has a direct bearing on the use of nuclear power, that balancing risks and benefits must become a standard approach to evaluating environmental matters and that the present crisis in confidence over energy requires this approach. (UK)

  3. Balancing sport risk and health benefits.

    Science.gov (United States)

    Matheson, G O

    1999-06-01

    A substantial part of our work as physicians involves treating sport- and exercise-related injuries. We also recommend exercise, knowing that it will result in a certain number of acute and overuse injuries. As team physicians, we attend competitive events despite awareness that participants in certain sports run a high risk of significant harm. So then, where do we stand in relation to the Hippocratic Oath: "First do no harm"?

  4. FIGO IIIB squamous cell carcinoma of the cervix: an analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy

    International Nuclear Information System (INIS)

    Logsdon, Mark D.; Eifel, Patricia J.

    1999-01-01

    Purpose: To define patient, tumor, and treatment factors that influence the outcome of patients with FIGO Stage IIIB squamous cell carcinoma of the intact uterine cervix. Methods and Materials: The records of 1,096 patients treated with radiation therapy between 1960 and 1993 for FIGO Stage IIIB squamous cell carcinoma of the intact uterine cervix were reviewed retrospectively. Of these, 983 (90%) were treated with curative intent and 113 were treated only to achieve palliation of symptoms. Of 907 patients who completed the intended curative treatment, 641 (71%) were treated with a combination of external beam irradiation (EBRT) and intracavitary irradiation (ICRT) and 266 (29%) were treated with EBRT only. The median duration of treatment for these 907 patients was 51 days. Between 1966 and 1980, only 52% of patients who completed treatment with curative intent received ICRT, compared with 92% of patients treated during 1981-1993, an increase that reflects an evolution in the philosophy of treatment for advanced tumors. In general, the intensity of ICRT correlated inversely with the dose of EBRT to the central pelvis. Median follow-up of surviving patients was 134 months. Results: For 983 patients treated with initial curative intent, disease-specific survival (DSS) was significantly worse for those who were 52 Gy of EBRT to the central pelvis had DSS rates of 27-34%, compared with 53% for patients treated with lower doses of EBRT to the central pelvis and more intensive ICRT (p 52 Gy of EBRT to the central pelvis (57-68%), compared with those who had 48-52 Gy (28%) and those who had ≤ 47 Gy of EBRT to the central pelvis (15%) (p < 0.0001). Outcome was also compared for four time periods during which different treatment policies were in place for patients with Stage IIIB disease. The highest DSS (51%) and lowest actuarial complication rate (17%) were achieved during the most recent period (1981-1993) when modest doses of EBRT were combined with relatively

  5. Balancing Audio

    DEFF Research Database (Denmark)

    Walther-Hansen, Mads

    2016-01-01

    This paper explores the concept of balance in music production and examines the role of conceptual metaphors in reasoning about audio editing. Balance may be the most central concept in record production, however, the way we cognitively understand and respond meaningfully to a mix requiring balance...... is not thoroughly understood. In this paper I treat balance as a metaphor that we use to reason about several different actions in music production, such as adjusting levels, editing the frequency spectrum or the spatiality of the recording. This study is based on an exploration of a linguistic corpus of sound...

  6. Getting the balance right

    International Nuclear Information System (INIS)

    1987-01-01

    This 8 page leaflet is published by the Nuclear Electricity Information Group (NEIG) which is made up of eight different bodies working within the nuclear industry. It aims to present a balanced outline of the facts needed to form an opinion about energy policy in the UK. It looks at the price of electricity, other sources of electricity, (oil and coal, solar power, wind power, water power), safety in the nuclear industry, nuclear waste disposal and risks from radiation. The NEIG is in favour of a balanced energy programme with nuclear energy being only a part of the overall scheme. (U.K.)

  7. The relative benefits of tamoxifen in older women with T1 early-stage breast cancer treated with breast-conserving surgery and radiation therapy.

    Science.gov (United States)

    Khan, Atif J; Parikh, Rahul R; Neboori, Hanmanth J; Goyal, Sharad; Haffty, Bruce G; Moran, Meena S

    2013-01-01

    Small, hormone receptor-positive breast carcinomas in older women are associated with low local recurrence rates. The relative benefits of adjuvant hormonal therapy remain unclear in elderly women with small, node-negative breast cancer after breast-conserving surgery and adjuvant radiation therapy. From our institutional data base, 224 patients ≥65 years of age with T1N0M0 breast cancer treated with BCS+RT were identified. Of these, 102 patients (45.5%) received tamoxifen (TAM) and 122 patients (54.5%) did not (no-TAM). The median follow-up time was 62.6 months. The 10-year local relapse-free survival (LRFS) was 98% in both the TAM and no-TAM cohorts (p = 0.58); the 10-year DMFS was 83% TAM vs. 89% no-TAM (p = 0.91). There was no difference in 10-year contralateral breast relapse or overall survival (OS) between the two cohorts. In univariate and multivariate analysis, use of TAM was not associated with LRFS, distant metastases-free survival (DMFS), OS, or a reduction in contralateral breast cancers when compared with the no-TAM cohort. In this large cohort of T1N0 elderly breast cancer patients treated with CS+RT, the use of TAM did not appear to decrease ipsilateral breast relapse, contralateral breast relapse, distant metastasis, or OS. © 2013 Wiley Periodicals, Inc.

  8. Balancing Act

    Science.gov (United States)

    Part of being an Active, More Powerful You means finding balance in your daily life: taking on the Must-dos and finding time for some Should Dos and Want-to-Dos. Sometimes, emotions and commitments can come into play and upset the balance.

  9. Balanced sampling

    NARCIS (Netherlands)

    Brus, D.J.

    2015-01-01

    In balanced sampling a linear relation between the soil property of interest and one or more covariates with known means is exploited in selecting the sampling locations. Recent developments make this sampling design attractive for statistical soil surveys. This paper introduces balanced sampling

  10. Balanced Integrated Regulatory Oversight

    International Nuclear Information System (INIS)

    Borchardt, R.W.

    2010-01-01

    Reactor safety, protecting the public health and safety, and protecting the environment must always be the nuclear regulator's top priorities. Enabling the use of nuclear power for the benefit of society, while protecting the public and the environment requires the regulator to balance many factors. In addition, the regulator is only one part of the overall government that must consider many factors as it carries out its societal responsibilities. Some of the factors that must be balanced and the practical impacts on how the regulator carries out its responsibilities will be addressed. The first International Conference on Effective Regulatory Systems, held in Moscow, Russian Federation, in 2006, focused on safety and security challenges with a goal of improving regulatory effectiveness through cooperation and sharing of information and best practices. The challenge of meeting both safety and security objectives is one example of potentially competing programmes that must be balanced. Other balances that must be evaluated include the benefits of safety improvements compared to the cost of implementation, the use of deterministic and probabilistic approaches, communication openness balanced with the protection of information that could be used for detrimental purposes, and timeliness of regulatory decision making balanced with the need to perform quality work in support of oversight responsibilities. A balanced and integrated approach to regulatory oversight is vital to ensuring that the regulatory body remains effective in its mission to enable the use of nuclear power while protecting the public and the environment. This concept is applicable to nations beginning a nuclear programme as well as established and experienced regulatory bodies. (author)

  11. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium.

    Science.gov (United States)

    Clement, S C; Kremer, L C M; Verburg, F A; Simmons, J H; Goldfarb, M; Peeters, R P; Alexander, E K; Bardi, E; Brignardello, E; Constine, L S; Dinauer, C A; Drozd, V M; Felicetti, F; Frey, E; Heinzel, A; van den Heuvel-Eibrink, M M; Huang, S A; Links, T P; Lorenz, K; Mulder, R L; Neggers, S J; Nieveen van Dijkum, E J M; Oeffinger, K C; van Rijn, R R; Rivkees, S A; Ronckers, C M; Schneider, A B; Skinner, R; Wasserman, J D; Wynn, T; Hudson, M M; Nathan, P C; van Santen, H M

    2018-02-01

    Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process. Recommendations were graded according to the strength of underlying evidence and potential benefit gained by early detection and appropriate management. Of the two available surveillance strategies, thyroid ultrasound and neck palpation, neither was shown to be superior. Consequently, a decision aid was formulated to guide the health care provider in counseling the survivor. The recommendations highlight the need for shared decision making regarding whether to undergo surveillance for DTC and in the choice of surveillance modality. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Potential dosimetric benefits of adaptive tumor tracking over the internal target volume concept for stereotactic body radiation therapy of pancreatic cancer.

    Science.gov (United States)

    Karava, Konstantina; Ehrbar, Stefanie; Riesterer, Oliver; Roesch, Johannes; Glatz, Stefan; Klöck, Stephan; Guckenberger, Matthias; Tanadini-Lang, Stephanie

    2017-11-09

    Radiotherapy for pancreatic cancer has two major challenges: (I) the tumor is adjacent to several critical organs and, (II) the mobility of both, the tumor and its surrounding organs at risk (OARs). A treatment planning study simulating stereotactic body radiation therapy (SBRT) for pancreatic tumors with both the internal target volume (ITV) concept and the tumor tracking approach was performed. The two respiratory motion-management techniques were compared in terms of doses to the target volume and organs at risk. Two volumetric-modulated arc therapy (VMAT) treatment plans (5 × 5 Gy) were created for each of the 12 previously treated pancreatic cancer patients, one using the ITV concept and one the tumor tracking approach. To better evaluate the overall dose delivered to the moving tumor volume, 4D dose calculations were performed on four-dimensional computed tomography (4DCT) scans. The resulting planning target volume (PTV) size for each technique was analyzed. Target and OAR dose parameters were reported and analyzed for both 3D and 4D dose calculation. Tumor motion ranged from 1.3 to 11.2 mm. Tracking led to a reduction of PTV size (max. 39.2%) accompanied with significant better tumor coverage (p<0.05, paired Wilcoxon signed rank test) both in 3D and 4D dose calculations and improved organ at risk sparing. Especially for duodenum, stomach and liver, the mean dose was significantly reduced (p<0.05) with tracking for 3D and 4D dose calculations. By using an adaptive tumor tracking approach for respiratory-induced pancreatic motion management, a significant reduction in PTV size can be achieved, which subsequently facilitates treatment planning, and improves organ dose sparing. The dosimetric benefit of tumor tracking is organ and patient-specific.

  13. Development of radiation protection standards at EPA

    International Nuclear Information System (INIS)

    Meyers, S.

    1987-01-01

    Development of EPA radiation protection standards combines the elements of risk assessment and risk management. The process of risk assessment consists of technical evaluation of the source term, environmental transport mechanisms, and biological effects. Engineering evaluations provide data on control options and costs. The risk management process considers the scope of legal authorities and the balancing of costs and benefits of alternatives within the framework of national priorities. The regulatory process provides for substantial public participation and is subject to legal reviews

  14. Balance Disorders

    Science.gov (United States)

    ... disorder can profoundly affect daily activities and cause psychological and emotional hardship. What are the symptoms of ... that help with balance but are destroyed by aging, medications, infections, or trauma can someday be regrown ...

  15. Does radiation dose to the vestibule predict change in balance function and patient perceived dizziness following stereotactic radiotherapy for vestibular schwannoma?

    Science.gov (United States)

    Stavas, Mark J; Carlson, Matthew L; Attia, Albert; Jacobson, Gary P; Rivas, Alejandro; Morales-Paliza, Manuel; Wanna, George B

    2014-01-01

    To date, the majority of the vestibular schwannoma (VS) literature has focused on tumor control rates, facial nerve function and hearing preservation. Other factors that have been shown to significantly affect quality-of-life (QOL), such as dizziness, remain understudied. The primary objective of the current study is to investigate the association between radiation dose to the vestibule and post-treatment changes in vestibular function and patient reported dizziness handicap. This is a prospective observational pilot study at a tertiary academic referral center including all subjects that underwent linear accelerator-based stereotactic radiotherapy (SRS) for sporadic VS and completed pre-treatment and post-treatment vestibular testing and Dizziness Handicap Inventory (DHI) questionnaires. Associations between objective vestibular test results, patient-reported DHI scores and radiation dose parameters were investigated. Ten patients met inclusion criteria. Tumor control was achieved in all individuals. There were no statistically significant associations or identifiable trends between radiation dose and change in vestibular function or DHI scores. Notably, the four ears receiving the highest vestibular dose had minimal changes in vestibular function tests and DHI scores. To the best of our knowledge, no previous reports have described the association between radiation dose to the vestibule and post-treatment changes in vestibular function and patient reported DHI. Based on these preliminary data, radiation dose to the vestibule does not reliably predict change in objective or subjective vestibular outcome measures. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. The Comparison of Matching Methods Using Different Measures of Balance: Benefits and Risks Exemplified within a Study to Evaluate the Effects of German Disease Management Programs on Long-Term Outcomes of Patients with Type 2 Diabetes.

    Science.gov (United States)

    Fullerton, Birgit; Pöhlmann, Boris; Krohn, Robert; Adams, John L; Gerlach, Ferdinand M; Erler, Antje

    2016-10-01

    To present a case study on how to compare various matching methods applying different measures of balance and to point out some pitfalls involved in relying on such measures. Administrative claims data from a German statutory health insurance fund covering the years 2004-2008. We applied three different covariance balance diagnostics to a choice of 12 different matching methods used to evaluate the effectiveness of the German disease management program for type 2 diabetes (DMPDM2). We further compared the effect estimates resulting from applying these different matching techniques in the evaluation of the DMPDM2. The choice of balance measure leads to different results on the performance of the applied matching methods. Exact matching methods performed well across all measures of balance, but resulted in the exclusion of many observations, leading to a change of the baseline characteristics of the study sample and also the effect estimate of the DMPDM2. All PS-based methods showed similar effect estimates. Applying a higher matching ratio and using a larger variable set generally resulted in better balance. Using a generalized boosted instead of a logistic regression model showed slightly better performance for balance diagnostics taking into account imbalances at higher moments. Best practice should include the application of several matching methods and thorough balance diagnostics. Applying matching techniques can provide a useful preprocessing step to reveal areas of the data that lack common support. The use of different balance diagnostics can be helpful for the interpretation of different effect estimates found with different matching methods. © Health Research and Educational Trust.

  17. Socioeconomic benefits

    African Journals Online (AJOL)

    User

    perception on the benefits of shade trees in coffee production systems in southwestern ..... Table 4. Other socioeconomic benefits of coffee shade tree species alluded by the respondents, Southwestern Ethiopia. Mentioned benefits. Responses (%). Yes. No. Firewood ... (fast growth, longevity, possession of thin and small ...

  18. Instruments for radiation measurement in life sciences (4). 7. Application of accelerator mass spectrometry for drug development. Human mass balance studies at discovery stage

    International Nuclear Information System (INIS)

    Miyaoka, Teiji

    2005-01-01

    Following the recent trend of Position Paper issued from European Agency for the Evaluation of Medicinal Products on the non-clinical safety studies to support clinical trials with a single micro dose, human mass balance studies at discovery stages were made with special interest in using AMS (accelerator mass spectrometry) with a small amount of hot (radioisotope-labeled) drug. This method was found to be effective for the purpose of screening in the clinical study for pharmaceutical development. To show an example of the test, 5, 50, 500μg/body of C14-ARA (α1A adrenoreceptor antagonist, 50 nCi or 1.85 kBq/body/dose) were given (cross over) to several persons to be inspected and C14-quantity in the blood plasma or urine was determined with AMS until after 168 hours or so. The results of the present experiment demonstrate that human mass balance study at discovery stages is possible with ultra high sensitive measuring systems such as AMS and PET (positron emission tomography). (S. Ohno)

  19. Wii balance board exercise improves balance and lower limb muscle strength of overweight young adults

    OpenAIRE

    Siriphorn, Akkradate; Chamonchant, Dannaovarat

    2015-01-01

    [Purpose] The potential health benefits of the Nintendo Wii balance board exercise have been widely investigated. However, no study has been conducted to examine the benefits of Wii exercise for overweight young adults. The aim of this study was to investigate the effect of exercise performed on a Nintendo Wii balance board on the balance and lower limb muscle strength in overweight young adults. [Subjects and Methods] Within-subject repeated measures analysis was used. Sixteen young adults (...

  20. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Haytham [Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Department of Medical Physiology and Cell Biology, Qena Faculty of Medicine, South Valley University (Egypt); Galal, Omima [Department of Medical Physiology and Cell Biology, Qena Faculty of Medicine, South Valley University (Egypt); Urata, Yoshishige; Goto, Shinji; Guo, Chang-Ying; Luo, Lan [Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Abdelrahim, Eman [Department of Medical Histology, Qena Faculty of Medicine, South Valley University (Egypt); Ono, Yusuke [Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Mostafa, Emtethal [Department of Medical Physiology and Cell Biology, Qena Faculty of Medicine, South Valley University (Egypt); Li, Tao-Sheng, E-mail: litaoshe@nagasaki-u.ac.jp [Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan)

    2014-09-26

    Highlights: • Nicaraven mitigated the radiation-induced reduction of c-kit{sup +} stem cells. • Nicaraven enhanced the function of hematopoietic stem/progenitor cells. • Complex mechanisms involved in the protection of nicaraven to radiation injury. - Abstract: Nicaraven, a hydroxyl radical-specific scavenger has been demonstrated to attenuate radiation injury in hematopoietic stem cells with 5 Gy γ-ray exposures. We explored the effect and related mechanisms of nicaraven for protecting radiation injury induced by sequential exposures to a relatively lower dose γ-ray. C57BL/6 mice were given nicaraven or placebo within 30 min before exposure to 50 mGy γ-ray daily for 30 days in sequences (cumulative dose of 1.5 Gy). Mice were victimized 24 h after the last radiation exposure, and the number, function and oxidative stress of hematopoietic stem cells were quantitatively estimated. We also compared the gene expression in these purified stem cells from mice received nicaraven and placebo treatment. Nicaraven increased the number of c-kit{sup +} stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60–90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function was completely protected with nicaraven treatment. Furthermore, nicaraven treatment changed the expression of many genes associated to DNA repair, inflammatory response, and immunomodulation in c-kit{sup +} stem/progenitor cells. Nicaraven effectively protected against damages of hematopoietic stem/progenitor cells induced by sequential exposures to a relatively low dose radiation, via complex mechanisms.

  1. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures

    International Nuclear Information System (INIS)

    Ali, Haytham; Galal, Omima; Urata, Yoshishige; Goto, Shinji; Guo, Chang-Ying; Luo, Lan; Abdelrahim, Eman; Ono, Yusuke; Mostafa, Emtethal; Li, Tao-Sheng

    2014-01-01

    Highlights: • Nicaraven mitigated the radiation-induced reduction of c-kit + stem cells. • Nicaraven enhanced the function of hematopoietic stem/progenitor cells. • Complex mechanisms involved in the protection of nicaraven to radiation injury. - Abstract: Nicaraven, a hydroxyl radical-specific scavenger has been demonstrated to attenuate radiation injury in hematopoietic stem cells with 5 Gy γ-ray exposures. We explored the effect and related mechanisms of nicaraven for protecting radiation injury induced by sequential exposures to a relatively lower dose γ-ray. C57BL/6 mice were given nicaraven or placebo within 30 min before exposure to 50 mGy γ-ray daily for 30 days in sequences (cumulative dose of 1.5 Gy). Mice were victimized 24 h after the last radiation exposure, and the number, function and oxidative stress of hematopoietic stem cells were quantitatively estimated. We also compared the gene expression in these purified stem cells from mice received nicaraven and placebo treatment. Nicaraven increased the number of c-kit + stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60–90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function was completely protected with nicaraven treatment. Furthermore, nicaraven treatment changed the expression of many genes associated to DNA repair, inflammatory response, and immunomodulation in c-kit + stem/progenitor cells. Nicaraven effectively protected against damages of hematopoietic stem/progenitor cells induced by sequential exposures to a relatively low dose radiation, via complex mechanisms

  2. Balancing Risk

    DEFF Research Database (Denmark)

    Nygaard, Lene; Rossen, Camilla Blach; Buus, Niels

    2015-01-01

    This study explored how eight pregnant women diagnosed with depression managed the decision whether or not to take antidepressants during pregnancy. In total, 11 interviews were conducted and analysed by means of constructivist grounded theory. The major category constructed was Balancing risk......, with two minor categories: Assessing depression and antidepressants and Evaluating the impact of significant others. The participants tried to make the safest decision, taking all aspects of their life into consideration. They described successful decision-making in the context of managing social norms...

  3. Solar ultraviolet radiation induces biological alterations in human skin in vitro: relevance of a well-balanced UVA/UVB protection.

    Science.gov (United States)

    Bernerd, Francoise; Marionnet, Claire; Duval, Christine

    2012-06-01

    Cutaneous damages such as sunburn, pigmentation, and photoaging are known to be induced by acute as well as repetitive sun exposure. Not only for basic research, but also for the design of the most efficient photoprotection, it is crucial to understand and identify the early biological events occurring after ultraviolet (UV) exposure. Reconstructed human skin models provide excellent and reliable in vitro tools to study the UV-induced alterations of the different skin cell types, keratinocytes, fibroblasts, and melanocytes in a dose- and time-dependent manner. Using different in vitro human skin models, the effects of UV light (UVB and UVA) were investigated. UVB-induced damages are essentially epidermal, with the typical sunburn cells and DNA lesions, whereas UVA radiation-induced damages are mostly located within the dermal compartment. Pigmentation can also be obtained after solar simulated radiation exposure of pigmented reconstructed skin model. Those models are also highly adequate to assess the potential of sunscreens to protect the skin from UV-associated damage, sunburn reaction, photoaging, and pigmentation. The results showed that an effective photoprotection is provided by broad-spectrum sunscreens with a potent absorption in both UVB and UVA ranges.

  4. Solar ultraviolet radiation induces biological alterations in human skin in vitro: Relevance of a well-balanced UVA/UVB protection

    Directory of Open Access Journals (Sweden)

    Françoise Bernerd

    2012-01-01

    Full Text Available Cutaneous damages such as sunburn, pigmentation, and photoaging are known to be induced by acute as well as repetitive sun exposure. Not only for basic research, but also for the design of the most efficient photoprotection, it is crucial to understand and identify the early biological events occurring after ultraviolet (UV exposure. Reconstructed human skin models provide excellent and reliable in vitro tools to study the UV-induced alterations of the different skin cell types, keratinocytes, fibroblasts, and melanocytes in a dose- and time-dependent manner. Using different in vitro human skin models, the effects of UV light (UVB and UVA were investigated. UVB-induced damages are essentially epidermal, with the typical sunburn cells and DNA lesions, whereas UVA radiation-induced damages are mostly located within the dermal compartment. Pigmentation can also be obtained after solar simulated radiation exposure of pigmented reconstructed skin model. Those models are also highly adequate to assess the potential of sunscreens to protect the skin from UV-associated damage, sunburn reaction, photoaging, and pigmentation. The results showed that an effective photoprotection is provided by broad-spectrum sunscreens with a potent absorption in both UVB and UVA ranges.

  5. Image-producing procedures for non-medical applications. Benefits, risks, radiation protection; Bildgebende Verfahren im nicht medizinischen Bereich. Nutzen, Risiken, Strahlenschutz

    Energy Technology Data Exchange (ETDEWEB)

    Czarwinski, Renate [Bundesamt fuer Strahlenschutz, Berlin (Germany); Estier, Sybille [Bundesamt fuer Gesundheit (BAG), Liebefeld (Switzerland). Direktionsbereich Verbraucherschutz; Huhn, Walter [Ministerium fuer Arbeit, Integration und Soziales NRW, Duesseldorf (Germany); Lorenz, Bernd [Lorenz Consulting, Essen (Germany); Vahlbruch, Jan [Hannover Univ. (Germany). Inst. fuer Radiooekologie und Strahlenschutz (IRS); Henning, Ulrich; Michel, Rolf

    2016-05-01

    A survey is given of image-producing procedures for non-medical applications, and this under technical, juridical and radiation protection aspects. The historical development of these procedures is also described. An example is given for today's practical application.

  6. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.

    Science.gov (United States)

    Ali, Haytham; Galal, Omima; Urata, Yoshishige; Goto, Shinji; Guo, Chang-Ying; Luo, Lan; Abdelrahim, Eman; Ono, Yusuke; Mostafa, Emtethal; Li, Tao-Sheng

    2014-09-26

    Nicaraven, a hydroxyl radical-specific scavenger has been demonstrated to attenuate radiation injury in hematopoietic stem cells with 5Gy γ-ray exposures. We explored the effect and related mechanisms of nicaraven for protecting radiation injury induced by sequential exposures to a relatively lower dose γ-ray. C57BL/6 mice were given nicaraven or placebo within 30min before exposure to 50mGy γ-ray daily for 30days in sequences (cumulative dose of 1.5Gy). Mice were victimized 24h after the last radiation exposure, and the number, function and oxidative stress of hematopoietic stem cells were quantitatively estimated. We also compared the gene expression in these purified stem cells from mice received nicaraven and placebo treatment. Nicaraven increased the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function was completely protected with nicaraven treatment. Furthermore, nicaraven treatment changed the expression of many genes associated to DNA repair, inflammatory response, and immunomodulation in c-kit(+) stem/progenitor cells. Nicaraven effectively protected against damages of hematopoietic stem/progenitor cells induced by sequential exposures to a relatively low dose radiation, via complex mechanisms. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. X-ray diagnostics - benefits and risks

    International Nuclear Information System (INIS)

    Bartholomaeus, Melanie

    2016-01-01

    The brochure on benefits and risks of X-ray diagnostics discusses the following issues: X radiation - a pioneering discovery and medical sensation, fundamentals of X radiation, frequency of X-ray examinations in Germany in relation to CT imaging, radiation doses resulting from X-ray diagnostics, benefits of X-ray diagnostics - indication and examples, risks - measures for radiation exposure reductions, avoidance of unnecessary examinations.

  8. Benefits of adopting good radiation practices in reducing the whole body radiation dose to the nuclear medicine personnel during (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging.

    Science.gov (United States)

    Verma, Shashwat; Kheruka, Subhash Chand; Maurya, Anil Kumar; Kumar, Narvesh; Gambhir, Sanjay; Kumari, Sarita

    2016-01-01

    Positron emission tomography has been established as an important imaging modality in the management of patients, especially in oncology. The higher gamma radiation energy of positron-emitting isotopes poses an additional radiation safety problem. Those working with this modality may likely to receive higher whole body doses than those working only in conventional nuclear medicine. The radiation exposure to the personnel occurs in dispensing the dose, administration of activity, patient positioning, and while removing the intravenous (i.v.) cannula. The estimation of radiation dose to Nuclear Medicine Physician (NMP) involved during administration of activity to the patient and technical staff assisting in these procedures in a positron emission tomography/computed tomography (PET/CT) facility was carried out. An i.v access was secured for the patient by putting the cannula and blood sugar was monitored. The activity was then dispensed and measured in the dose calibrator and administered to the patient by NMP. Personnel doses received by NMP and technical staff were measured using electronic pocket dosimeter. The radiation exposure levels at various working locations were assessed with the help of gamma survey meter. The radiation level at working distance while administering the radioactivity was found to be 106-170 μSv/h with a mean value of 126.5 ± 14.88 μSv/h which was reduced to 4.2-14.2 μSv/h with a mean value of 7.16 ± 2.29 μSv/h with introduction of L-bench for administration of radioactivity. This shows a mean exposure level reduction of 94.45 ± 1.03%. The radiation level at working distance, while removing the i.v. cannula postscanning was found to be 25-70 μSv/h with a mean value of 37.4 ± 13.16 μSv/h which was reduced to 1.0-5.0 μSv/h with a mean value of 2.77 ± 1.3 μSv/h with introduction of L-bench for removal of i.v cannula. This shows a mean exposure level reduction of 92.85 ± 1.78%. This study shows that good radiation practices are

  9. Optimizing the balance between radiation dose and image quality in pediatric head CT: findings before and after intensive radiologic staff training.

    Science.gov (United States)

    Paolicchi, Fabio; Faggioni, Lorenzo; Bastiani, Luca; Molinaro, Sabrina; Puglioli, Michele; Caramella, Davide; Bartolozzi, Carlo

    2014-06-01

    The purpose of this study was to assess the radiation dose and image quality of pediatric head CT examinations before and after radiologic staff training. Outpatients 1 month to 14 years old underwent 215 unenhanced head CT examinations before and after intensive training of staff radiologists and technologists in optimization of CT technique. Patients were divided into three age groups (0-4, 5-9, and 10-14 years), and CT dose index, dose-length product, tube voltage, and tube current-rotation time product values before and after training were retrieved from the hospital PACS. Gray matter conspicuity and contrast-to-noise ratio before and after training were calculated, and subjective image quality in terms of artifacts, gray-white matter differentiation, noise, visualization of posterior fossa structures, and need for repeat CT examination was visually evaluated by three neuroradiologists. The median CT dose index and dose-length product values were significantly lower after than before training in all age groups (27 mGy and 338 mGy ∙ cm vs 107 mGy and 1444 mGy ∙ cm in the 0- to 4-year-old group, 41 mGy and 483 mGy ∙ cm vs 68 mGy and 976 mGy ∙ cm in the 5- to 9-year-old group, and 51 mGy and 679 mGy ∙ cm vs 107 mGy and 1480 mGy ∙ cm in the 10- to 14-year-old group; p training were significantly lower than the levels before training (p staff training can be effective in reducing radiation dose while preserving diagnostic image quality in pediatric head CT examinations.

  10. Keeping Your Balance

    Science.gov (United States)

    ... Exercise/Safe Movement › Keeping Your Balance Keeping Your Balance Balance is very important for people with osteoporosis. Your ... all play an important role in maintaining your balance and preventing broken bones. Medical conditions and medicines ...

  11. H.R. 2738: A bill to amend title 38, United States Code, with respect to benefits for individuals who may have been exposed to ionizing radiation during military service, and for other purposes, introduced in the US House of Representatives, One Hundred Second Congress, First Session, June 24, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill was introduced into the US House of Representatives on June 24, 1991 to amend title 38, United States Code with respect to benefits for individuals who may have been exposed to ionizing radiation during military service. Key features addressed in separate sections include the following: expansion of a list of diseases presumed to be service-connected for certain radiation-exposed veteran and elimination of latency-period limitations; and adjudication of claims based on exposure to ionizing radiation

  12. Radiation Therapy for Skin Cancer

    Science.gov (United States)

    ... make sure they are safe to use during radiation therapy. • Eat a balanced diet. If food tastes funny ... melanoma.org Skin Cancer Foundation www.skincancer.org Radiation Therapy Answers www.rtanswers.org LEARNING ABOUT CLINICAL TRIALS ...

  13. Radiation carcinogenesis

    International Nuclear Information System (INIS)

    Fry, R.J.M.

    1976-01-01

    The risk of iatrogenic tumors with radiation therapy is so outweighed by the benefit of cure that estimates of risk have not been considered necessary. However, with the introduction of chemotherapy, combined therapy, and particle radiation therapy, the comparative risks should be examined. In the case of radiation, total dose, fractionation, dose rate, dose distribution, and radiation quality should be considered in the estimation of risk. The biological factors that must be considered include incidence of tumors, latent period, degree of malignancy, and multiplicity of tumors. The risk of radiation induction of tumors is influenced by the genotype, sex, and age of the patient, the tissues that will be exposed, and previous therapy. With chemotherapy the number of cells at risk is usually markedly higher than with radiation therapy. Clearly the problem of the estimation of comparative risks is complex. This paper presents the current views on the comparative risks and the importance of the various factors that influence the estimation of risk

  14. Effects of radiation-counselling convergence education on radiation awareness

    International Nuclear Information System (INIS)

    Seoung, Youl Hun

    2017-01-01

    The purpose of study was to analysis on the effects of radiation-counselling convergence education on radiation awareness. The survey objects were students of radiation-counselling convergence education from 12th May to 22th June in 2016. The questionnaires were education satisfactions and radiation awareness (risk, benefit, control) by Likert-type 5 scales. The analysis results revealed that education satisfactions of men students showed a significant higher female students and correlation coefficient of education satisfactions were the best high in the benefit and control of radiation. Finally radiation-counselling convergence education had a significant effect on radiation benefit. This convergence education influenced positive recognition on radiation benefit and it was indicated that radiation-counselors could treat clients on the basis of radiation benefit

  15. Effects of radiation-counselling convergence education on radiation awareness

    Energy Technology Data Exchange (ETDEWEB)

    Seoung, Youl Hun [Dept. of Radiological Science, College of Health Science, Cheongju University, Cheongju (Korea, Republic of)

    2017-06-15

    The purpose of study was to analysis on the effects of radiation-counselling convergence education on radiation awareness. The survey objects were students of radiation-counselling convergence education from 12th May to 22th June in 2016. The questionnaires were education satisfactions and radiation awareness (risk, benefit, control) by Likert-type 5 scales. The analysis results revealed that education satisfactions of men students showed a significant higher female students and correlation coefficient of education satisfactions were the best high in the benefit and control of radiation. Finally radiation-counselling convergence education had a significant effect on radiation benefit. This convergence education influenced positive recognition on radiation benefit and it was indicated that radiation-counselors could treat clients on the basis of radiation benefit.

  16. The Medical Exposure to Ionizing Radiation and Protection of the Patient in Medical Imaging Procedures for Diagnostic and Therapeutic Purposes (Excluding Radiotherapy) using X-Rays in Israel - Risk - Cost and Benefit

    International Nuclear Information System (INIS)

    Ben-Shlomo, A.

    1998-10-01

    Diagnostic and therapeutic radiology is playing a major role in modern medicine. The utilization of devices emitting ionizing radiation for medical diagnostic and therapeutic purposes is classified into three categories: a. Radiotherapy procedures for the treatment of malignant and benign tumors. b. Nuclear medicine procedures using radiopharmaceuticals that are introduced into the patient's body for diagnostic and therapeutic purposes. c. Diagnostic and therapeutic x-ray imaging procedures. This group includes conventional radiography, conventional fluoroscopy, cardiac catheterization, angiography, CT, mammography, dental, and fluoroscopy operation procedures. A survey was carried out on a sample of three major Israeli hospitals in order to: 1. Determine the status of radiation protection of patients in Israel with regard to the use of x-rays in medical imaging and interventional radiology. 2. Assess the extent of exposure of the population to medical x-rays, and assess the collective risk in Israel in this relation (based on Icr-60). 3. Carry out a cost-benefit optimization procedure related to the means that should be used to reduce the exposure of Israeli patients under x-ray procedures. 4. Establish a of practical recommendations to reduce the x-ray radiation exposure of patients and to increase the image quality. 5. Establish a number of basic rules to be utilized by health policy makers in Israel

  17. Prospects of topical protection from ultraviolet radiation exposure: a critical review on the juxtaposition of the benefits and risks involved with the use of chemoprotective agents.

    Science.gov (United States)

    Bora, Nilutpal Sharma; Mazumder, Bhaskar; Chattopadhyay, Pronobesh

    2017-08-18

    Solar ultraviolet (UV) radiation exposure is known to cause inevitable damage to human skin via different mechanisms which include disruption of genetic material and generation of free radicals. In the ever emerging field of photoprotective agents, there have been constant endeavors to uphold the standards for optimum protection from solar UV-induced damages which include alarming conditions ranging from severe keratosis to malignant transformation of skin cells. Out of the various methods available for photoprotection, chemical photoprotective agents are most popular due to its ease of applicability, availability, and efficacy. However, the benevolences of chemophotoprotective agents are not excluded from the fact that all chemical agents are bound to suffer predestined consequences of toxicity and unwanted side effects. The present article focuses on the basic knowledge pertaining to achieve adequate sun protection and also on the beneficial and risk factors of using chemical agents as photoprotective formulations. The article highlights the US Food and Drug Administration (FDA) approved and unapproved UV filters; and also sheds light on the overall measures to protect an individual from UV radiation exposure, dispel misconceptions and present the newer technologies that are available in the market to accomplish ideal sun protection.

  18. Impactos do avanço da soja no balanço de radiação no leste da Amazônia Impacts of soybean expansion on radiation balance in eastern Amazon

    Directory of Open Access Journals (Sweden)

    Paulo Jorge de Oliveira Ponte de Souza

    2013-06-01

    environmental impacts can be generated due to the presence of soybean monoculture in the region. This study evaluates the local impacts of the replacement of forest by soybean (Glycine max (L. Merrill on radiation balance components in an area that represents the agricultural border advancement in Amazonia. A micrometeorological experiment was installed in an area of soybean cultivation in Paragominas-PA and data from forest ecosystems were collected in Caxiuanã forests located in Melgaço-PA both during 2006 and 2007. During the soybean growing season the mean impact found in net radiation represented a reduction of 17.9% of the value commonly observed in the forest. During the off-season the impact on net radiation was 15.5%. Principal mechanisms that control these impacts were associated with the high soybean albedo and high loss of long wave radiation. Although the greatest impact occurs during the crop growing season, the time of occurrence of this negative effect is restricted to only 1/3 of the year, which leads to a higher impact of the off-season on energy balance in cumulative terms.

  19. Synchrotron radiation

    International Nuclear Information System (INIS)

    Poole, M.W.; Lea, K.R.

    1982-01-01

    A report is given on the work involving the Synchrotron Radiation Division of the Daresbury Laboratory during the period January 1981 - March 1982. Development of the source, beamlines and experimental stations is described. Progress reports from individual investigators are presented which reveal the general diversity and interdisciplinary nature of the research which benefits from access to synchrotron radiation and the associated facilities. Information is given on the organisation of the Division and publications written by the staff are listed. (U.K.)

  20. The impact of comorbidities on the benefits of prolonged androgen ablation in patients with T3-4 prostate cancer treated with external beam radiation therapy.

    Science.gov (United States)

    Tran, Eric; Paquette, Matthew; Jay, Justin; Hamm, Jeremy; Liu, Mitchell; Duncan, Graeme; Pickles, Tom; Tyldesley, Scott

    2017-08-01

    To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584). Duration of ADT and baseline prognostic factors (age, clinical stage, grade, presenting PSA, and Charlson index (CCI)) were abstracted from charts. Estimates of 10-year (E10) survival using an age-adjusted CCI were calculated and patients were grouped into low (90%) E10. In each E10 group, actual overall survivals were compared by era using log rank test. There were 318 low, 544 medium, and 447 high E10 patients with median follow-up of 11.1years. Gleason grade and T stage were not statistically different between E10 groups. As expected, median age and baseline CCI were higher in lower E10 groups (pbenefit that varies with baseline risk of death from other causes. Absolute benefit from ADT is largest in those with medium or high E10. Copyright © 2017. Published by Elsevier B.V.

  1. The mass balance of the Greenland ice sheet: sensitivity to climate change as revealed by energy-balance modelling

    NARCIS (Netherlands)

    Oerlemans, J.

    1991-01-01

    The sensitivity of the mass balance of the Greenland ice sheet to climate change is studied with an energy-balance model of the ice/snow surface, applied at 200 m elevation intervals for four characteristic regions of the ice sheet. Solar radiation, longwave radiation, turbulent heat fluxes

  2. Energy balance climate models

    Science.gov (United States)

    North, G. R.; Cahalan, R. F.; Coakley, J. A., Jr.

    1981-01-01

    An introductory survey of the global energy balance climate models is presented with an emphasis on analytical results. A sequence of increasingly complicated models involving ice cap and radiative feedback processes are solved, and the solutions and parameter sensitivities are studied. The model parameterizations are examined critically in light of many current uncertainties. A simple seasonal model is used to study the effects of changes in orbital elements on the temperature field. A linear stability theorem and a complete nonlinear stability analysis for the models are developed. Analytical solutions are also obtained for the linearized models driven by stochastic forcing elements. In this context the relation between natural fluctuation statistics and climate sensitivity is stressed.

  3. WORK / LIFE BALANCE REFLECTIONS ON EMPLOYEE SATISFACTION

    Directory of Open Access Journals (Sweden)

    Selvarani

    2011-03-01

    Full Text Available The aim of this research is to analyze the relationship between employee satisfaction andwork/life balance. The construct used for this research consists of career opportunity, recognition,work tasks, payments, benefits, superior subordinate relationship, employee satisfaction, andwork/life balance. The study was conducted on a total of 210 respondents working in IT organization.This study makes a contribution to join two distinct research streams, namely employee satisfaction,and work/life balance. Findings suggest that high correlation exists between work task and employeesatisfaction with a mediator variable namely work-life balance.

  4. Radiation safety

    International Nuclear Information System (INIS)

    1996-04-01

    Most of the ionizing radiation that people are exposed to in day-to-day activities comes from natural, rather than manmade, sources. The health effects of radiation - both natural and artificial - are relatively well understood and can be effectively minimized through careful safety measures and practices. The IAEA, together with other international and expert organizations, is helping to promote and institute Basic Safety Standards on an international basis to ensure that radiation sources and radioactive materials are managed for both maximum safety and human benefit

  5. H.R. 1972: A bill to amend title 38, United States Code, with respect to benefits for veterans who may have been exposed to ionizing radiation during military service, and for other purposes, introduced in the US House of Representatives, One Hundred Second Congress, First Session, April 22, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill was introduced into the US House of Representatives on April 22, 1991 to amend title 38, United States Code. This legislation involves benefits for veterans who may have been exposed to ionizing radiation during military service. Individual sections address the following: expansion of presumption of service connection for certain radiation-exposed reservists; expansion of list of diseases presumed to be service-connected for certain radiation-exposed veterans and elimination of latency-period limitations; and adjudication of claims based on exposure to ionizing radiation

  6. Content and style of radiation risk communication for pediatric patients.

    Science.gov (United States)

    Broder, Joshua S; Frush, Donald P

    2014-03-01

    The diagnostic benefits of medical imaging, including CT, must be weighed against the risks of ionizing radiation and communicated effectively to patients. Health care providers requesting and performing these examinations have a shared responsibility for this risk-benefit discussion. Effective and balanced communication of these risks requires style as well as content mastery. Fundamentals of communication are similar for all patients, but special attention is needed in the pediatric setting. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  7. Fringe Benefits.

    Science.gov (United States)

    Podgursky, Michael

    2003-01-01

    Uses statistics from the National Center for Education Statistics and the Bureau of Labor Statistics to examine teacher salaries and benefits. Discusses compensation of teachers compared with nonteachers. Asserts that statistics from the American Federation of Teachers and the National Education Association underestimate teacher compensation…

  8. Radiation protection forum

    International Nuclear Information System (INIS)

    Cabral, W.

    2010-01-01

    The National Director of the Nuclear Regulatory Authority and Radiation Protection of Uruguay in the first forum for radiation protection set out the following themes: activity of regulatory body, radiation safety, physical security, safeguards, legal framework, committed substantive program, use of radiation, risks and benefits, major sources of radiation, the national regulatory framework, national inventory of sources, inspections, licensing, import and export of sources control , radioactive transport, materials safety, agreements, information and teaching, radiological emergencies and prompt response.

  9. Conventional myelography - evaluation of risk and benefit

    International Nuclear Information System (INIS)

    Hentschel, F.

    1989-01-01

    While the benefit and methodic risk of conventional myelography (KMG) are known, a radiation risk of 0.04 to 0.9 annual radiation-induced cancers can be estimated for all inhabitants of the GDR, dependent on the investigated region and the technique used. An optimized technique can reduce the radiation burden to 50 or 25%. With comparable values of benefit and radiation risk spinal CT and KMG are not contradictory but complementary investigations. Alternative methods (MRT, US) must not be discussed from the standpoint of radiation burden, but according to their availability and their methodic limitations. (author)

  10. Legal issues in cash balance pension plan conversions.

    Science.gov (United States)

    Forman, J B

    2001-01-01

    Replacing a traditional pension with a cash balance plan raises a number of complicated and unsettled legal issues, including the protection of accrued benefits, the rate of benefit accrual, age discrimination and notice requirements. This article discusses those issues and concludes that routine conversions to cash balance plans appear to be legal both currently and into the foreseeable future.

  11. Additional Survival Benefit of Involved-Lesion Radiation Therapy After R-CHOP Chemotherapy in Limited Stage Diffuse Large B-Cell Lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jeanny [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Il Han, E-mail: ihkim@snu.ac.kr [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea, Republic of); Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of); Kim, Byoung Hyuck [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Tae Min; Heo, Dae Seog [Department of Internal Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)

    2015-05-01

    Purpose: The purpose of this study was to evaluate the role of involved-lesion radiation therapy (ILRT) after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy in limited stage diffuse large B-cell lymphoma (DLBCL) by comparing outcomes of R-CHOP therapy alone with R-CHOP followed by ILRT. Methods and Materials: We identified 198 patients treated with R-CHOP (median, 6 cycles) for pathologically confirmed DLBCL of limited stage from July 2004 to December 2012. Clinical characteristics of these patients were 33% with stage I and 66.7% with stage II; 79.8% were in the low or low-intermediate risk group; 13.6% had B symptoms; 29.8% had bulky tumors (≥7 cm); and 75.3% underwent ≥6 cycles of R-CHOP therapy. RT was given to 43 patients (21.7%) using ILRT technique, which included the prechemotherapy tumor volume with a median margin of 2 cm (median RT dose: 36 Gy). Results: After a median follow-up of 40 months, 3-year progression-free survival (PFS) and overall survival (OS) were 85.8% and 88.9%, respectively. Multivariate analysis showed ≥6 cycles of R-CHOP (PFS, P=.004; OS, P=.004) and ILRT (PFS, P=.021; OS, P=.014) were favorable prognosticators of PFS and OS. A bulky tumor (P=.027) and response to R-CHOP (P=.012) were also found to be independent factors of OS. In subgroup analysis, the effect of ILRT was prominent in patients with a bulky tumor (PFS, P=.014; OS, P=.030) or an elevated level of serum lactate dehydrogenase (LDH; PFS, P=.004; OS, P=.012). Conclusions: Our results suggest that ILRT after R-CHOP therapy improves PFS and OS in patients with limited stage DLBCL, especially in those with bulky disease or an elevated serum LDH level.

  12. Balancing interests: limitations to the right to enjoy the benefits of scientific progress and its applications / Une balance des intérêts - Les restrictions au droit de bénéficier du progrès scientifique et de ses applications

    NARCIS (Netherlands)

    Donders, Y.

    2015-01-01

    The right to enjoy the benefits of scientific progress and its applications (REBSP) is still, despite increased attention from United Nations (UN) human rights bodies and academics, very much unknown. Several studies and reports have been elaborated on the normative content and State obligations of

  13. Who benefits?

    DEFF Research Database (Denmark)

    Hjorth, Frederik Georg

    2016-01-01

    Cross-border welfare rights for citizens of European Union member states are intensely contested, yet there is limited research into voter opposition to such rights, sometimes denoted ‘welfare chauvinism’. We highlight an overlooked aspect in scholarly work: the role of stereotypes about benefici...... recipient identity. These effects are strongest among respondents high in ethnic prejudice and economic conservatism. The findings imply that stereotypes about who benefits from cross-border welfare rights condition public support for those rights....

  14. Continued Benefit to Androgen Deprivation Therapy for Prostate Cancer Patients Treated With Dose-Escalated Radiation Therapy Across Multiple Definitions of High-Risk Disease

    International Nuclear Information System (INIS)

    Stenmark, Matthew H.; Blas, Kevin; Halverson, Schuyler; Sandler, Howard M.; Feng, Felix Y.; Hamstra, Daniel A.

    2011-01-01

    Purpose: To analyze prognostic factors in patients with high-risk prostate cancer treated with dose-escalated external-beam radiation therapy (EBRT) and androgen deprivation (ADT). Methods and Materials: Between 1998 and 2008 at University of Michigan Medical Center, 718 men were consecutively treated with EBRT to at least 75 Gy. Seven definitions of high-risk prostate cancer, applying to 11–33% of patients, were evaluated. Biochemical failure (BF), salvage ADT use, metastatic progression, and prostate cancer–specific mortality (PCSM) were estimated by the Kaplan-Meier method and Cox proportional hazards regression. Results: Each high-risk definition was associated with increased BF (hazard ratio [HR] 2.8–3.9, p < 0.0001), salvage ADT use (HR 3.9–6.3, p < 0.0001), metastasis (HR 3.7–6.6, p < 0.0001), and PCSM (HR 3.7–16.2, p < 0.0001). Furthermore, an increasing number of high-risk features predicted worse outcome. Adjuvant ADT yielded significant reductions in both metastases (HR 0.19–0.38, p < 0.001) and PCSM (HR 0.38–0.50, p < 0.05) for all high-risk definitions (with the exception of clinical Stage T3–4 disease) but improved BF only for those with elevated Gleason scores (p < 0.03, HR 0.25–0.48). When treated with ADT and dose-escalated EBRT, patients with Gleason scores 8 to 10, without other high-risk features, had 8-year freedom from BF of 74%, freedom from distant metastases of 93%, and cause-specific survival of 92%, with salvage ADT used in 16% of patients. Conclusion: Adjuvant ADT results in a significant improvement in clinical progression and PCSM across multiple definitions of high-risk disease even with dose-escalated EBRT. There is a subset of patients, characterized by multiple high-risk features or the presence of Gleason Pattern 5, who remain at significant risk for metastasis and PCSM despite current treatment.

  15. Balancing safety and economics

    International Nuclear Information System (INIS)

    Kroeger, W.; Fischer, P.U.

    2000-01-01

    The safety requirements of NPPs have always aimed at limiting societal risks. This risk approach initially resulted in deterministic design criteria and concepts. In the 1980s the paradigm 'safety at all costs' arose and often led to questionable backfitting measures. Conflicts between new requirements, classical design concepts and operational demands were often ignored. The design requirements for advanced reactors ensure enhanced protection against severe accidents. Still, it is questionable whether the 'no-damage-outside-the-fence' criteria can be achieved deterministically and at competitive costs. Market deregulation and utility privatisation call for a balance between safety and costs, without jeopardising basic safety concepts. An ideal approach must be risk-based and imply modern PSAs and new methods for cost-benefit and ALARA analyses, embed nuclear risks in a wider risk spectrum, but also make benefits transparent within the context of a broader life experience. Governments should define basic requirements, minimum standards and consistent comparison criteria, and strengthen operator responsibility. Internationally sufficient and binding safety requirements must be established and nuclear technology transfer handled in a responsible way, while existing plants, with their continuous backfitting investments, should receive particular attention. (orig.)

  16. SU-E-T-361: Clinical Benefit of Automatic Beam Gating Mixed with Breath Hold in Radiation Therapy of Left Breast

    International Nuclear Information System (INIS)

    Wu, J; Hill, G; Spiegel, J; Ye, J; Mehta, V

    2014-01-01

    Purpose: To investigate the clinical and dosimetric benefits of automatic gating of left breast mixed with breath-hold technique. Methods: Two Active Breathing Control systems, ABC2.0 and ABC3.0, were used during simulation and treatment delivery. The two systems are different such that ABC2.0 is a breath-hold system without beam control capability, while ABC3.0 has capability in both breath-hold and beam gating. At simulation, each patient was scanned twice: one with free breathing (FB) and one with breath hold through ABC. Treatment plan was generated on the CT with ABC. The same plan was also recalculated on the CT with FB. These two plans were compared to assess plan quality. For treatments with ABC2.0, beams with MU > 55 were manually split into multiple subfields. All subfields were identical and shared the total MU. For treatment with ABC3.0, beam splitting was unnecessary. Instead, treatment was delivered in gating mode mixed with breath-hold technique. Treatment delivery efficiency using the two systems was compared. Results: The prescribed dose was 50.4Gy at 1.8Gy/fraction. The maximum heart dose averaged over 10 patients was 46.0±2.5Gy and 24.5±12.2Gy for treatments with FB and with ABC respectively. The corresponding heart V10 was 13.2±3.6% and 1.0±1.6% respectively. The averaged MUs were 99.8±7.5 for LMT, 99.2±9.4 for LLT. For treatment with ABC2.0, normally the original beam was split into 2 subfields. The averaged total time to delivery all beams was 4.3±0.4min for treatments with ABC2.0 and 3.3±0.6min for treatments with ABC3.0 in gating mode. Conclusion: Treatment with ABC tremendously reduced heart dose. Compared to treatments with ABC2.0, gating with ABC3.0 reduced the total treatment time by 23%. Use of ABC3.0 improved the delivery efficiency, and eliminated the possibility of mistreatments. The latter may happen with ABC2.0 where beam is not terminated when breath signal falls outside of the treatment window

  17. Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

    Science.gov (United States)

    Cooper, Cyrus; Bardin, Thomas; Brandi, Maria-Luisa; Cacoub, Patrice; Caminis, John; Civitelli, Roberto; Cutolo, Maurizio; Dere, Willard; Devogelaer, Jean-Pierre; Diez-Perez, Adolfo; Einhorn, Thomas A; Emonts, Patrick; Ethgen, Olivier; Kanis, John A; Kaufman, Jean-Marc; Kvien, Tore K; Lems, Willem F; McCloskey, Eugene; Miossec, Pierre; Reiter, Susanne; Ringe, Johann; Rizzoli, René; Saag, Kenneth; Reginster, Jean-Yves

    2016-02-01

    This consensus review article considers the question of whether glucocorticoid (GC) therapy is still relevant in the treatment of rheumatic diseases, with a particular focus on rheumatoid arthritis (RA), and whether its side effects can be adequately managed. Recent basic and clinical research on the molecular, cellular and clinical effects of GCs have considerably advanced our knowledge in this field. An overview of the subject seems appropriate. This review is the result of a multidisciplinary expert working group, organised by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. The recent literature was surveyed and the salient evidence synthetized. The pathophysiological basis of RA (and other inflammatory rheumatic diseases) now strongly implicates the adaptive immune system in addition to innate mechanisms. The molecular effect of GCs and differential GC sensitivity is better understood, although exploiting this knowledge is still in its infancy. The newer treatment strategies of early and aggressive control of RA have gr eatly improved clinical outcomes, but improvements are still possible. Newer targeted anti-inflammatory drugs have made an important impact, yet they too are associated with numerous side effects. Short durations of moderate doses of GCs are generally well tolerated and have a positive benefit/risk ratio. Patients should be assessed for fracture risk and bone preserving agents and be prescribed calcium and vitamin D supplementation. Within a strategy of a disease modifying approach to inflammatory disease, combination therapy including a GC is effective approach.

  18. (Mis)Understanding Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Schreiber, Stephen Bruce [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-10

    This set of slides discusses radiation and fears concerning it at a non-technical level. Included are some misconceptions and practical consequences resulting from these. The concept of radiation hormesis is explained. The author concludes that a number of significant societal benefits are being foregone because of overly cautious concerns about low-level radiation.

  19. Your organization should consider a cash-balance pension plan.

    Science.gov (United States)

    Godwin, N H; Key, K G

    2000-08-01

    In recent years, a growing number of healthcare organizations have dropped the traditional defined-benefit pension plan and adopted cash-balance pension plans. A cash-balance pension plan generally allows employers to pay less in overall pension benefits and administration costs. A cash-balance pension plan pays benefits according to a predetermined formula based on an average of the employee's annual salary over his or her length of service. This provides recognizable benefits to younger employees but lower overall benefits to employees who have a long length of service. To assuage employees who may feel cheated out of the pension benefits they expected, employers that change to a cash-balance pension plan should consider offering higher guaranteed growth rates, advanced notification of the change to the new plan, and generous early-retirement options for employees with longer lengths of service.

  20. How will transitioning from cytology to HPV testing change the balance between the benefits and harms of cervical cancer screening? Estimates of the impact on cervical cancer, treatment rates and adverse obstetric outcomes in Australia, a high vaccination coverage country.

    Science.gov (United States)

    Velentzis, Louiza S; Caruana, Michael; Simms, Kate T; Lew, Jie-Bin; Shi, Ju-Fang; Saville, Marion; Smith, Megan A; Lord, Sarah J; Tan, Jeffrey; Bateson, Deborah; Quinn, Michael; Canfell, Karen

    2017-12-15

    high vaccination coverage, is therefore expected to both improve the benefits (further decrease risk of cervical cancer) and reduce the harms (reduce treatments and possible obstetric complications) associated with cervical cancer screening. © 2017 UICC.

  1. Radiation education in school

    International Nuclear Information System (INIS)

    Shishido, Teruko; Higashijima, Emiko; Hisajima, Michihiro

    2005-01-01

    Part of goals of general education of physics is to provide students for basic knowledge on radiation. This includes understanding of both its risks and benefits. Students should know how to protect and defence from radiation but they should not overwhelm the risk of radiation. Sometimes, students think that atomic power is so terrible and frightening that they keep away from use of atomic power. Basic knowledge about risks of radiation will reduce the excessive reaction or anxiety coming from radiation. It also makes people understand other possible risks and benefits of radiation accompanied by modern scientific technologies such as nuclear technologies. We believe that the radiation education is an essential requisite for the peaceful usage of nuclear energy and radiation technology for the future. (author)

  2. Wii balance board exercise improves balance and lower limb muscle strength of overweight young adults.

    Science.gov (United States)

    Siriphorn, Akkradate; Chamonchant, Dannaovarat

    2015-01-01

    [Purpose] The potential health benefits of the Nintendo Wii balance board exercise have been widely investigated. However, no study has been conducted to examine the benefits of Wii exercise for overweight young adults. The aim of this study was to investigate the effect of exercise performed on a Nintendo Wii balance board on the balance and lower limb muscle strength in overweight young adults. [Subjects and Methods] Within-subject repeated measures analysis was used. Sixteen young adults (aged 21.87±1.13 years, body mass index 24.15 ± 0.50 kg/m(2)) were recruited. All subjects performed an exercise program on a Wii balance board for 8 weeks (30 min/session, twice a week for 8 weeks). A NeuroCom Balance Master and a hand-held dynamometer were used to measure balance performance and lower limb muscle strength. [Results] According to the comparison of pre- and post-intervention measurements, the Wii balance board exercise program significantly improved the limit of stability parameters. There was also a significant increase in strength of four lower-limb muscle groups: the hip flexor, knee flexor, ankle dorsiflexor and ankle plantarflexor. [Conclusion] These findings suggest that a Wii balance board exercise program can be used to improve the balance and lower limb muscle strength of overweight young adults.

  3. Balanced Scorecard voor inkoop

    NARCIS (Netherlands)

    van der Honing, R.; Schotanus, Fredo

    2003-01-01

    Een Balanced Scorecard kan ontwikkeld worden voor de hele organisatie, maar ook voor onderdelen daarvan. In dit artikel wordt ingegaan op de ontwikkeling van een Balanced Scorecard voor de inkoopafdeling

  4. Effect of therapeutic horseback riding on balance in community-dwelling older adults with balance deficits.

    Science.gov (United States)

    Homnick, Douglas N; Henning, Kim M; Swain, Charlene V; Homnick, Tamara D

    2013-07-01

    Falls are an important cause of morbidity in older adults. Equine-assisted activities including therapeutic riding (TR) benefit balance and neuromuscular control in patients with neurological disabilities but have not been systematically studied in older adults at greater risk for falls due to balance deficits. The effect of an 8-week TR program on measures of balance and quality of life in community-dwelling older adults with established balance deficits was evaluated. This was a pretest-post-test single-group trial of a TR program on measures of balance and quality of life. The study was conducted at a Professional Association of Therapeutic Horsemanship (PATH) International Premier riding center. The subjects comprised 9 adults (5 female, 4 males) with a mean age 76.4 years (range 71-83 years). This included an 8-week observation period followed by an 8-week TR program consisting of 1 hour per week of supervised horseback riding and an 8-week follow-up period. SUBJECTS received balance testing at weeks 0, 8, 16, and 24 using the Fullerton Advanced Balance Scale (FABS), and quality of life was measured at weeks 8 and 16 using the Rand SF (short form) 36 quality-of-life measure. OUTCOME MEASURES were change in the FABS and Rand SF 36. There was no significant difference in balance scores between the start and end of the observation period. There was a significant improvement in the balance score and perception of general health from the start to the end of the intervention period, and no significant difference between the end of the intervention and the end of study, suggesting that improvements may have been sustained. TR is a safe activity for older adults with mild to moderate balance deficits and leads to both improvements in balance and quality of life. Longer and larger studies to assess the benefit of equine-assisted activities on improvements in balance and reduction in fall risk are needed.

  5. Radiation versus radiation: nuclear energy in perspective

    International Nuclear Information System (INIS)

    Gonzalez, A.J.; Anderer, J.

    1989-01-01

    This paper seeks to provide a proper perspective on radiation exposures from nuclear energy. Instead of comparing these exposures with other pollutants, natural and man-made, it assesses the radiation doses that result from the human environment and from the entire fuel cycle associated with nuclear generated electricity. It explores radiation versus radiation, not only in terms of absolute levels but, more importantly, of the enormous variability characterizing many radiation sources. The quantitative findings and their implications are meant to contribute to a balanced understanding of the radiological impact of nuclear energy, and so to help to bridge the information gap that is perceived to exist on this issue. The 1988 Unscear report and its seven scientific annexes provide an authoritative and dispassionate factual basis for examining radiation levels from all sources, natural and man-made. It is the main source for this paper. (author)

  6. Balancing atmospheric carbon dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Goreau, T.J. (Discovery Bay Marine Laboratory, Univ. of the West Indies (JM))

    1990-01-01

    Rising carbon dioxide and global temperatures are causing increasing worldwide concern, and pressure towards an international law of the atmosphere is rapidly escalating, yet widespread misconceptions about the greenhouse effect's inevitability, time scale, and causes have inhibited effective consensus and action. Observations from Antarctic ice cores, Amazonian rain forests, and Carribean coral reefs suggest that the biological effects of climate change may be more severe than climate models predict. Efforts to limit emissions from fossil-fuel combustion alone are incapable of stabilizing levels of carbon dioxide in the atmosphere. Stabilizing atmospheric carbon dioxide requires coupled measures to balance sources and sinks of the gas, and will only be viable with large-scale investments in increased sustainable productivity on degraded tropical soils, and in long-term research on renewable energy and biomass product development in the developing countries. A mechanism is outlined which directly links fossil-fuel combustion sources of carbon dioxide to removal via increasing biotic productivity and storage. A preliminary cost-benefit analysis suggests that such measures are very affordable, costing far less than inaction. (With 88 refs.).

  7. Effect of summer snowfall on glaciermass balance

    NARCIS (Netherlands)

    Oerlemans, J.; Klok, E.J.

    It has been postulated that heavy summer snowfalls have a large impact on the mass balance of mid-latitude glaciers, because they simultaneously add mass to the glacier and reduce the amount of absorbed solar radiation. An automatic weather station (AWS) on the snout of Morteratschgletscher,

  8. Get the Balance Right.

    Science.gov (United States)

    Haddock, Rebecca Jaurigue

    Today work goes on 24 hours a day, 7 days a week, and is about acceleration and access. Workers need balance more than ever. In fact, recent college graduates value work/life balance as their key factor in selecting employers. This paper, written for career counselors, defines balance as encompassing emotional, spiritual, physical, and…

  9. DYMAC digital electronic balance

    International Nuclear Information System (INIS)

    Stephens, M.M.

    1980-06-01

    The Dynamic Materials Accountability (DYMAC) System at LASL integrates nondestructive assay (NDA) instruments with interactive data-processing equipment to provide near-real-time accountability of the nuclear material in the LASL Plutonium Processing Facility. The most widely used NDA instrument in the system is the DYMAC digital electronic balance. The DYMAC balance is a commercial instrument that has been modified at LASL for weighing material in gloveboxes and for transmitting the weight data directly to a central computer. This manual describes the balance components, details the LASL modifications, reviews a DYMAC measurement control program that monitors balance performance, and provides instructions for balance operation and maintenance

  10. Suicides in Adolescents: Benefit/Harm Balance of Antidepressants

    Science.gov (United States)

    Saz, Ulas Eylem; Arslan, Mehmet Tayyip; Egemen, Ayten

    2007-01-01

    Introduction: Depression is an important cause of suicide in adolescents. It has been speculated that antidepressants themselves can increase the risk of suicide. Method: Cases of adolescents admitted to the Ege University Pediatric Emergency Department in Turkey due to suicide attempt were assessed. Results: Nine of 13 suicide attempts during…

  11. Benefits Of Mission Command: Balance Of Philosophy And System

    Science.gov (United States)

    2016-05-26

    all I’ve got. Good luck to you , and God bless you and your men.23 Upon arrival to Taejon on the morning of July 1, 1950, LTC Smith found BG Church...ABSTRACT On October 31, 2014, the US Anny Training and Doctrine Command published The US Anny Operating Concept: Win in a Complex World (AOC) . The...On October 31, 2014, the US Army Training and Doctrine Command published The US Army Operating Concept: Win in a Complex World (AOC). The purpose of

  12. Agriculture and biodiversity: a better balance benefits both

    Directory of Open Access Journals (Sweden)

    Jan Willem Erisman

    2016-04-01

    Full Text Available Sustainable agriculture is an important component of many of the 17 Sustainable Development Goals agreed upon by the UN in 2015 (https://sustainabledevelopment.un.org/sdgs. However, the trend in agriculture is moving in the opposite, non-sustainable direction. Agriculture is one of the major drivers of biodiversity loss. Next to biodiversity loss due to habitat destruction by conversion of natural lands into agriculture, intensification of agriculture has led to a strong decline of specific farmland biodiversity. Furthermore, many agricultural landscapes face pollution by pesticides and fertilizers, and encounter depleted soils and erosion due to unsustainable farming practices. This is threatening not only biodiversity but also complete ecosystems and the ecosystem services on which agriculture itself depends. Moreover, the pressure of feeding an increasing number of people in combination with a change in diets towards more animal protein puts a lot of additional pressure on the current available agricultural lands and nature areas.We propose a holistic approach that contributes to the development and implementation of sustainable agricultural practices that both make use and support biodiversity and ecosystem services both in agricultural and in semi-natural areas. An agricultural system based on the full potential of (functional agro biodiversity provides opportunities to create a resilient system in which both food production and nature can thrive.

  13. Prednisone and Other Corticosteroids: Balance the Risks and Benefits

    Science.gov (United States)

    ... lower legs High blood pressure Problems with mood, memory, behavior and other psychological effects Weight gain, with fat deposits in your abdomen, ... injected corticosteroids Injected corticosteroids can cause temporary ... skin thinning, loss of color in the skin, facial flushing, insomnia and high ...

  14. Balancing risk and benefit with oral hypoglycemic drugs.

    Science.gov (United States)

    Hamnvik, Ole-Petter R; McMahon, Graham T

    2009-06-01

    Clinicians are faced with an expansive array of treatment choices when caring for patients with type 2 diabetes. Because patient compliance may be affected when media sensationalism about controversial findings is misunderstood, we sought to clarify the recent controversy surrounding the cardiovascular and bone-health risks of thiazolidinediones, the risk of lactic acidosis with metformin, and the risk of hypoglycemia with oral therapies. The side effect profile of thiazolidinediones includes fluid retention, heart failure; and an increased risk of fracture. A recent controversial meta-analysis suggested that rosiglitazone increases the risk of myocardial infarction, which is possibly related to thiazolidinedione-induced lipid changes, weight gain, congestive heart failure, and anemia. Metformin is restricted to patients with normal renal function because of concerns that metformin may cause lactic acidosis. However, few cases of metformin-associated lactic acidosis have been reported, and most have occurred in patients with other reasons for developing lactic acidosis, such as sepsis or renal failure. Although the use of metformin continues to increase, observational studies have not been able to demonstrate an increased incidence of lactic acidosis in metformin-treated patients, even when it is used in populations with relative contraindications. Some oral hypoglycemic medications can cause hypoglycemia. Hypoglycemia is especially common in older patients, alcoholics, and patients with liver or renal disease. Patients on sulfonylureas and meglitinides have the highest incidence of hypoglycemia because of their pharmacological action of increasing insulin secretion. Of the sulfonylureas, glyburide presents the highest risk of hypoglycemia. Combination therapies, especially those regimens containing a sulfonylurea, increase the risk of hypoglycemia. (c) 2009 Mount Sinai School of Medicine.

  15. An energy balance model for the Greenland ice sheet

    NARCIS (Netherlands)

    Wal, R.S.W. van de; Oerlemans, J.

    1994-01-01

    The sensitivity of the mass balance of the Greenland Ice Sheet is studied by means of an energy balance model. The model calculates the shortwave and longwave radiation and the turbulent fluxes on a grid with a grid point spacing of 20 km. Special attention is given to the parameterization of the

  16. Angra-1: Balance of an experience

    International Nuclear Information System (INIS)

    Salvo Brito, S. de

    1985-01-01

    An evaluation of experience got during the construction of Angra-1 nuclear power plant which had built by FURNAS CENTRAIS ELETRICAS S.A. is done. It is analyzed the problems in level of management, including technology transfer. A balance of the real costs and benefits from the definition of the specifications to energy generation is done. (M.C.K.) [pt

  17. Effect of Balance Board Exercises on Balance Tests and Limits of Stability by Biodex Balance System in Normal Men

    Directory of Open Access Journals (Sweden)

    Ebrahim Esmaeili

    2006-07-01

    Full Text Available Objective: Despite tilt-board exercises benefits and its role in ligamentus us injury prevention, little research has been done in this case. The goal of this study is investigation of balance exercises effect for six weeks on balance tests and strength of lower extremity ligaments. Materials & Methods: In present Quasi experimental study, case group was consisted of two 17 subjects groups which did balance exercises for 6 weeks (one group on dominant limb and another on non-dominant limb.Control group did not do any exercise in this period. These groups were evaluated and re-evaluated before and after the exercise period by Biodex Balance System. Results: Statistical analysis revealed significant differences between groups (P<0/05. Conclusion: According to our results it can be concluded that tilt-board exercises can be used as a suitable tool to prevent ligamentus us injuries.

  18. Food biotechnology: benefits and concerns.

    Science.gov (United States)

    Falk, Michael C; Chassy, Bruce M; Harlander, Susan K; Hoban, Thomas J; McGloughlin, Martina N; Akhlaghi, Amin R

    2002-06-01

    Recent advances in agricultural biotechnology have highlighted the need for experimental evidence and sound scientific judgment to assess the benefits and risks to society. Nutrition scientists and other animal biologists need a balanced understanding of the issues to participate in this assessment. To date most modifications to crop plants have benefited producers. Crops have been engineered to decrease pesticide and herbicide usage, protect against stressors, enhance yields and extend shelf life. Beyond the environmental benefits of decreased pesticide and herbicide application, consumers stand to benefit by development of food crops with increased nutritional value, medicinal properties, enhanced taste and esthetic appeal. There remains concern that these benefits come with a cost to the environment or increased risk to the consumer. Most U.S. consumers are not aware of the extent that genetically modified foods have entered the marketplace. Consumer awareness of biotechnology seems to have increased over the last decade, yet most consumers remain confused over the science. Concern over the impact on the safety of the food supply remains low in the United States, but is substantially elevated in Europe. Before a genetically engineered crop is introduced into commerce it must pass regulatory scrutiny by as many as four different federal regulatory bodies to ensure a safe food supply and minimize the risk to the environment. Key areas for more research are evaluation of the nutritional benefits of new crops, further investigation of the environmental impact, and development of better techniques to identify and track genetically engineered products.

  19. Functional balance tests

    Directory of Open Access Journals (Sweden)

    Parvin Raji

    2012-12-01

    Full Text Available Background and Aim: All activities of daily living need to balance control in static and dynamic movements. In recent years, a numerous increase can be seen in the functional balance assessment tools. Functional balance tests emphasize on static and dynamic balance, balance in weight transfer, the equilibrium response to the imbalances, and functional mobility. These standardized and available tests assess performance and require minimal or no equipment and short time to run. Functional balance is prerequisite for the most static and dynamic activities in daily life and needs sufficient interaction between sensory and motor systems. According to the critical role of balance in everyday life, and wide application of functional balance tests in the diagnosis and assessment of patients, a review of the functional balance tests was performed.Methods: The Google Scholar, PubMed, Science Direct, Scopus, Magiran, Iran Medex, and IranDoc databases were reviewed and the reliable and valid tests which were mostly used by Iranian researchers were assessed.Conclusion: It seems that Berg balance scale (BBS have been studied by Iranian and foreign researches more than the other tests. This test has high reliability and validity in elderly and in the most neurological disorders.

  20. Quantum load balancing in ad hoc networks

    Science.gov (United States)

    Hasanpour, M.; Shariat, S.; Barnaghi, P.; Hoseinitabatabaei, S. A.; Vahid, S.; Tafazolli, R.

    2017-06-01

    This paper presents a novel approach in targeting load balancing in ad hoc networks utilizing the properties of quantum game theory. This approach benefits from the instantaneous and information-less capability of entangled particles to synchronize the load balancing strategies in ad hoc networks. The quantum load balancing (QLB) algorithm proposed by this work is implemented on top of OLSR as the baseline routing protocol; its performance is analyzed against the baseline OLSR, and considerable gain is reported regarding some of the main QoS metrics such as delay and jitter. Furthermore, it is shown that QLB algorithm supports a solid stability gain in terms of throughput which stands a proof of concept for the load balancing properties of the proposed theory.

  1. Radiation hazards of X-ray mammography

    International Nuclear Information System (INIS)

    Bailar, J.C. III

    1978-01-01

    X-ray mammography delivers significant amounts of ionizing radiation to the breast, and the female breast is more susceptible to radiation carcinogenesis than any other human organ. On the other hand, breast cancer is least likely to cause serious illness and death when it is detected at a very early stage. The risks and benefits of mammography can be estimated. This paper summarizes current risk estimates, then proceeds to a comparison of risks and benefits. As for breast cancer mortality, the addition of mammography to a programme of annual breast examinations of average U.S. women is of questionable value for women under age 50 but it is probably beneficial for older women. However, the break-even point is closely related to the average radiation exposure of breast tissue, and would be earlier in a few centres now using optimum techniques and equipment. For women with below-average risks of breast cancer, the age would be higher, and for a few women with a high probability of developing breast cancer it would be lower. Breast cancer screening programmes have been improved significantly since criticisms were first publicized in mid-1975. Partial improvements include reduction in radiation exposure (at least in some centres), guidelines from the National Cancer Institute (NCI) and the American Cancer Society (ACS) for restricting the screening of women under age 50, and changes in the patient consent form signed by participants in the NCI-ACS programme. Professional and public awareness of the need to balance the benefits of screening with its risks and costs has rapidly and markedly increased. Future improvements should further define the optimum design and application of breast cancer screening programmes

  2. Radiation in daily life

    International Nuclear Information System (INIS)

    Mora Rodriguez, P.

    1999-01-01

    The medical community benefits on a daily basis from the ionizing radiations used in the diagnosis and treatment of disease. The doses received in the medical field are only a small fraction of the total radiation received in a year. This bibliographic review has several objectives. The first one is to present the different components of natural radiation (background radiation). Secondly, it will introduce many consumer products that contain radioactive sources and expose our bodies. Third, arguments to diminish the radiation phobia will be presented and finally an easy to understand dosimetric magnitude will be introduced for the physician, the technologist and the patient. (author) [es

  3. Surgical Reconstruction of Radiation Injuries

    OpenAIRE

    Fujioka, Masaki

    2014-01-01

    Significance: Patients with cancer receive benefits from radiation therapy; however, it may have adverse effects on normal tissue such as causing radiation-induced ulcer and osteoradionecrosis. The most reliable method to treat a radiation ulcer is wide excision of the affected tissue, followed by coverage with well-vascularized tissue. As usual, radiation-induced skin ulcers are due to therapeutic irradiation for residual cancer or lymph nodes; the locations of radiation ulcers are relativel...

  4. Balanced microwave filters

    CERN Document Server

    Hong, Jiasheng; Medina, Francisco; Martiacuten, Ferran

    2018-01-01

    This book presents and discusses strategies for the design and implementation of common-mode suppressed balanced microwave filters, including, narrowband, wideband, and ultra-wideband filters This book examines differential-mode, or balanced, microwave filters by discussing several implementations of practical realizations of these passive components. Topics covered include selective mode suppression, designs based on distributed and semi-lumped approaches, multilayer technologies, defect ground structures, coupled resonators, metamaterials, interference techniques, and substrate integrated waveguides, among others. Divided into five parts, Balanced Microwave Filters begins with an introduction that presents the fundamentals of balanced lines, circuits, and networks. Part 2 covers balanced transmission lines with common-mode noise suppression, including several types of common-mode filters and the application of such filters to enhance common-mode suppression in balanced bandpass filters. Next, Part 3 exa...

  5. Benefit/risk comparisons in diagnostic radiology

    International Nuclear Information System (INIS)

    Oosterkamp, W.J.

    1976-01-01

    Benefit and risks in radiodiagnostic examination, either with X-rays or with radioactive isotopes, can be expressed in restored health and health impaired by radiation or: lives saved and estimated lives lost as a result of genetic or somatic radiation damage. Published data on benefit-risk comparisons for mass stomach and chest surveys show a considerable benefit surplus. It is demonstrated that this is also true in the case of clinical examinations of the sick. Efforts should be concentrated on better ways and means to reduce the number of diagnostic errors. Risk estimates should be made as realistic as possible

  6. Hohlraums energy balance and x-ray drive

    International Nuclear Information System (INIS)

    Kilkenny, J.D.

    1994-01-01

    For many years there has been an active ICF program in the US concentrating on x-ray drive. X-ray drive is produced by focusing laser beams into a high Z hohlraum. Conceptually, the radiation field comes close to thermodynamic equilibrium, that is it becomes isotropic and Planckian. These properties lead to the benefits of x-ray drive--it is relatively easy to obtain drive symmetry on a capsule with no small scalelengths drive perturbations. Other advantages of x-ray drive is the higher mass ablation rate, leading to lower growth rates for hydrodynamic instabilities. X-ray drive has disadvantages, principally the loss of energy to the walls of the hohlraum. This report is divided into the following sections: (1) review of blackbody radiation; (2) laser absorption and conversion to x-rays; (3) x-ray absorption coefficient in matter and Rosseland mean free path; (4) Marshak waves in high Z material; (5) x-ray albedo; and (6) power balance and hohlraum temperature

  7. Technology for Innovation in Radiation Oncology

    Energy Technology Data Exchange (ETDEWEB)

    Chetty, Indrin J. [Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan (United States); Martel, Mary K., E-mail: mmartel@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Jaffray, David A. [Departments of Radiation Oncology and Medical Biophysics, Princess Margaret Hospital, Toronto, Ontario (Canada); Benedict, Stanley H. [Department of Radiation Oncology, University of California – Davis Cancer Center, Sacramento, California (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Berbeco, Ross [Department of Radiation Oncology, Brigham and Women' s Hospital, Boston, Massachusetts (United States); Deye, James [Radiation Research Programs, National Cancer Institute, Bethesda, Maryland (United States); Jeraj, Robert [Department of Medical Physics, University of Wisconsin, Madison, Wisconsin (United States); Kavanagh, Brian [Department of Radiation Oncology, University of Colorado, Aurora, Colorado (United States); Krishnan, Sunil [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Nancy [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Low, Daniel A. [Department of Radiation Oncology, University of California – Los Angeles, Los Angeles, California (United States); Mankoff, David [Department of Radiology, University of Washington Medical School, Seattle, Washington (United States); Marks, Lawrence B. [Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina (United States); Ollendorf, Daniel [Institute for Clinical and Economic Review, Boston, Massachusetts (United States); and others

    2015-11-01

    Radiation therapy is an effective, personalized cancer treatment that has benefited from technological advances associated with the growing ability to identify and target tumors with accuracy and precision. Given that these advances have played a central role in the success of radiation therapy as a major component of comprehensive cancer care, the American Society for Radiation Oncology (ASTRO), the American Association of Physicists in Medicine (AAPM), and the National Cancer Institute (NCI) sponsored a workshop entitled “Technology for Innovation in Radiation Oncology,” which took place at the National Institutes of Health (NIH) in Bethesda, Maryland, on June 13 and 14, 2013. The purpose of this workshop was to discuss emerging technology for the field and to recognize areas for greater research investment. Expert clinicians and scientists discussed innovative technology in radiation oncology, in particular as to how these technologies are being developed and translated to clinical practice in the face of current and future challenges and opportunities. Technologies encompassed topics in functional imaging, treatment devices, nanotechnology, and information technology. The technical, quality, and safety performance of these technologies were also considered. A major theme of the workshop was the growing importance of innovation in the domain of process automation and oncology informatics. The technologically advanced nature of radiation therapy treatments predisposes radiation oncology research teams to take on informatics research initiatives. In addition, the discussion on technology development was balanced with a parallel conversation regarding the need for evidence of efficacy and effectiveness. The linkage between the need for evidence and the efforts in informatics research was clearly identified as synergistic.

  8. Technology for Innovation in Radiation Oncology

    International Nuclear Information System (INIS)

    Chetty, Indrin J.; Martel, Mary K.; Jaffray, David A.; Benedict, Stanley H.; Hahn, Stephen M.; Berbeco, Ross; Deye, James; Jeraj, Robert; Kavanagh, Brian; Krishnan, Sunil; Lee, Nancy; Low, Daniel A.; Mankoff, David; Marks, Lawrence B.; Ollendorf, Daniel

    2015-01-01

    Radiation therapy is an effective, personalized cancer treatment that has benefited from technological advances associated with the growing ability to identify and target tumors with accuracy and precision. Given that these advances have played a central role in the success of radiation therapy as a major component of comprehensive cancer care, the American Society for Radiation Oncology (ASTRO), the American Association of Physicists in Medicine (AAPM), and the National Cancer Institute (NCI) sponsored a workshop entitled “Technology for Innovation in Radiation Oncology,” which took place at the National Institutes of Health (NIH) in Bethesda, Maryland, on June 13 and 14, 2013. The purpose of this workshop was to discuss emerging technology for the field and to recognize areas for greater research investment. Expert clinicians and scientists discussed innovative technology in radiation oncology, in particular as to how these technologies are being developed and translated to clinical practice in the face of current and future challenges and opportunities. Technologies encompassed topics in functional imaging, treatment devices, nanotechnology, and information technology. The technical, quality, and safety performance of these technologies were also considered. A major theme of the workshop was the growing importance of innovation in the domain of process automation and oncology informatics. The technologically advanced nature of radiation therapy treatments predisposes radiation oncology research teams to take on informatics research initiatives. In addition, the discussion on technology development was balanced with a parallel conversation regarding the need for evidence of efficacy and effectiveness. The linkage between the need for evidence and the efforts in informatics research was clearly identified as synergistic.

  9. Technology for Innovation in Radiation Oncology.

    Science.gov (United States)

    Chetty, Indrin J; Martel, Mary K; Jaffray, David A; Benedict, Stanley H; Hahn, Stephen M; Berbeco, Ross; Deye, James; Jeraj, Robert; Kavanagh, Brian; Krishnan, Sunil; Lee, Nancy; Low, Daniel A; Mankoff, David; Marks, Lawrence B; Ollendorf, Daniel; Paganetti, Harald; Ross, Brian; Siochi, Ramon Alfredo C; Timmerman, Robert D; Wong, John W

    2015-11-01

    Radiation therapy is an effective, personalized cancer treatment that has benefited from technological advances associated with the growing ability to identify and target tumors with accuracy and precision. Given that these advances have played a central role in the success of radiation therapy as a major component of comprehensive cancer care, the American Society for Radiation Oncology (ASTRO), the American Association of Physicists in Medicine (AAPM), and the National Cancer Institute (NCI) sponsored a workshop entitled "Technology for Innovation in Radiation Oncology," which took place at the National Institutes of Health (NIH) in Bethesda, Maryland, on June 13 and 14, 2013. The purpose of this workshop was to discuss emerging technology for the field and to recognize areas for greater research investment. Expert clinicians and scientists discussed innovative technology in radiation oncology, in particular as to how these technologies are being developed and translated to clinical practice in the face of current and future challenges and opportunities. Technologies encompassed topics in functional imaging, treatment devices, nanotechnology, and information technology. The technical, quality, and safety performance of these technologies were also considered. A major theme of the workshop was the growing importance of innovation in the domain of process automation and oncology informatics. The technologically advanced nature of radiation therapy treatments predisposes radiation oncology research teams to take on informatics research initiatives. In addition, the discussion on technology development was balanced with a parallel conversation regarding the need for evidence of efficacy and effectiveness. The linkage between the need for evidence and the efforts in informatics research was clearly identified as synergistic. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Work-Life Balance

    OpenAIRE

    Kvasničková, Katarína

    2011-01-01

    The subject of this thesis is Work-Life Balance - the reconciliation of professional and personal lives. The primary objective of this work is to analyze employee satisfaction in achieving a balance between the professional and personal life and to develop recommendations for employer on that basis. The theoretical portion of this work defines the issues surrounding Work-Life Balance and tools that employees can use to harmonize the two with an analysis of applications in the Czech Republic a...

  11. Teaching Balance Training to Improve Stability and Cognition for Children

    Science.gov (United States)

    Shim, Andrew L.; Norman, Shannon P.; Kim, Young Ae

    2013-01-01

    There are many benefits to having young children train or practice on balance boards. The physical education setting allows educators to provide opportunities for youth to develop essential fitness skills that can be transferred into other life experiences. Balance-board activities and exercises can help in training the central and peripheral…

  12. Indoor ionizing radiation

    International Nuclear Information System (INIS)

    Ericson, S.O.; Lindvall, T.; Maansson, L-G.

    1986-01-01

    Radiation in indoor air is discussed in the perspective of the effective dose equivalents from other sources of radiation. Estimates of effective doses equivalents from indoor radon and its contribution to lung cancer incidence are reviewed. Swedish experiences with cost effective remedial actions are presented. The authors present optimal strategies for screening measurements and remedial actions in cost-benefit perspective. (author.)

  13. Risk versus benefit in radiology

    International Nuclear Information System (INIS)

    Samuel, E.

    1985-01-01

    The risks of radiology may be grouped into a) those inherent in the use of ionizing radiation which today are well known and b) those associated with the use of any scientific method in medicine. Inherent risks of scientific methods like inadequate examination and the interpretation of results are discussed. Radiology brought major benefits in medical care and some of the newer methods are considered

  14. Identifying Balance in a Balanced Scorecard System

    Science.gov (United States)

    Aravamudhan, Suhanya; Kamalanabhan, T. J.

    2007-01-01

    In recent years, strategic management concepts seem to be gaining greater attention from the academicians and the practitioner's alike. Balanced Scorecard (BSC) concept is one such management concepts that has spread in worldwide business and consulting communities. The BSC translates mission and vision statements into a comprehensive set of…

  15. A Smartphone Inertial Balance

    Science.gov (United States)

    Barrera-Garrido, Azael

    2017-01-01

    In order to measure the mass of an object in the absence of gravity, one useful tool for many decades has been the inertial balance. One of the simplest forms of inertial balance is made by two mass holders or pans joined together with two stiff metal plates, which act as springs.

  16. Lust-Balance

    NARCIS (Netherlands)

    Wouters, Cas

    2007-01-01

    The concept of the lust-balance refers to the social organization and accompanying social codes (ideals and practices) regarding the relationship between the longing for sexual gratification and the longing for enduring relational intimacy. It thus draws attention to the balance between emotive

  17. Conclusion: The balanced company

    DEFF Research Database (Denmark)

    Scheuer, John Damm; Jensen, Inger

    2013-01-01

    This concluding chapter brings together the various research findings of the book "The balanced company - organizing for the 21st Century" and develops a general overview of their implications for our understanding of the balancing processes unfolding in companies and organizations....

  18. Balance og stofskifte

    DEFF Research Database (Denmark)

    2011-01-01

    Udstilling på Medicinsk Museion. Baseret på bevilling fra Assens Fond. Se mere på http://www.museion.ku.dk/whats-on/exhibitions/balance-and-metabolism/......Udstilling på Medicinsk Museion. Baseret på bevilling fra Assens Fond. Se mere på http://www.museion.ku.dk/whats-on/exhibitions/balance-and-metabolism/...

  19. Potential risk and benefit of the combination of trastuzumab to chemotherapy and radiation therapy in non-metastatic breast cancer; Benefice et risques potentiels de l'association du trastuzumab a la chimiotherapie et a la radiotherapie dans le cancer du sein non metastatique

    Energy Technology Data Exchange (ETDEWEB)

    Belkacemi, Y. [CLCC Oscar-Lambret, Universite de Lille-2, Dept. d' Oncologie-Radiotherapie, 59 - Lille (France); Laharie-Mineur, H. [CLCC, institut Bergonie, 33 - Bordeaux (France); Gligorov, J. [APHP, Hopital Tenon, Cancer-Est, 75 - Paris (France); Azria, D. [CLCC Val d' Aurelle-Paul-Lamarque, Inserm, EMI 0227, 34 - Montpellier (France)

    2007-09-15

    Trastuzumab (Herceptin) is the first humanized monoclonal antibody targeting the HER2 antigen in breast cancer. HER2 receptor has been individualised 20 years ago. During the past 10 years, trastuzumab administration has radically modified the prognosis of the patients that are treated for HER2 positive breast cancer. Its efficacy has been demonstrated in the metastatic and adjuvant settings. While, trastuzumab based-regimens became the standard of care in the treatment of HER2/neu positive breast cancer, the optimal combination (concurrently or sequentially) to chemotherapy and radiation therapy is still unknown. Indeed, while the concurrent administration of trastuzumab and anthracyclines is not recommended because of a high risk of cardiac toxicity, there is no published data on the best sequence of trastuzumab and radiation therapy administration, particularly when internal mammary chain is involved. The benefit/risk ratio of the concurrent and sequential administration of trastuzumab with chemotherapy and radiation therapy will be discussed in this review. (authors)

  20. [The potential health benefits of philanthropy].

    Science.gov (United States)

    Vaccaro, Antoine

    2014-12-01

    The act of donating or doing voluntary or charitable work has a positive effect on the giver's health. Numerous French and international studies have shown the benefits of a voluntary activity. It enables people to live better and longer, by favouring their physical, psychological, social and cognitive balance.

  1. The effect of aerosols on long wave radiation and global warming

    OpenAIRE

    Zhou, You

    2015-01-01

    Long wave (LW) radiation in the Earth's atmosphere is defined as the radiation at wavelengths longer than 4 µm (infrared). The short wave (SW) radiation wavelengths are less than 4 µm (visible light, ultraviolet). SW radiation is usually from solar origin. The absorbed solar SW radiation is closely balanced by the outgoing LW radiation in the atmosphere. This radiation balance keeps the global average temperature stable. The main cause of the current global warming trend is human expansion of...

  2. Energy-balance climate models

    Science.gov (United States)

    North, G. R.; Cahalan, R. F.; Coakley, J. A., Jr.

    1980-01-01

    An introductory survey of the global energy balance climate models is presented with an emphasis on analytical results. A sequence of increasingly complicated models involving ice cap and radiative feedback processes are solved and the solutions and parameter sensitivities are studied. The model parameterizations are examined critically in light of many current uncertainties. A simple seasonal model is used to study the effects of changes in orbital elements on the temperature field. A linear stability theorem and a complete nonlinear stability analysis for the models are developed. Analytical solutions are also obtained for the linearized models driven by stochastic forcing elements. In this context the relation between natural fluctuation statistics and climate sensitivity is stressed.

  3. Load Balancing Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  4. Applying the balanced scorecard in healthcare provider organizations.

    Science.gov (United States)

    Inamdar, Noorein; Kaplan, Robert S; Bower, Marvin

    2002-01-01

    Several innovative healthcare executives have recently introduced a new business strategy implementation tool: the Balanced Scorecard. The scorecard's measurement and management system provides the following potential benefits to healthcare organizations: It aligns the organization around a more market-oriented, customer-focused strategy It facilitates, monitors, and assesses the implementation of the strategy It provides a communication and collaboration mechanism It assigns accountability for performance at all levels of the organization It provides continual feedback on the strategy and promotes adjustments to marketplace and regulatory changes. We surveyed executives in nine provider organizations that were implementing the Balanced Scorecard. We asked about the following issues relating to its implementation and effect: 1. The role of the Balanced Scorecard in relation to a well-defined vision, mission, and strategy 2. The motivation for adopting the Balanced Scorecard 3. The difference between the Balanced Scorecard and other measurement systems 4. The process followed to develop and implement the Balanced Scorecard 5. The challenges and barriers during the development and implementation process 6. The benefits gained by the organization from adoption and use. The executives reported that the Balanced Scorecard strategy implementation and performance management tool could be successfully applied in the healthcare sector, enabling organizations to improve their competitive market positioning, financial results, and customer satisfaction. This article concludes with guidelines for other healthcare provider organizations to capture the benefits of the Balanced Scorecard performance management system.

  5. Errors in potassium balance

    International Nuclear Information System (INIS)

    Forbes, G.B.; Lantigua, R.; Amatruda, J.M.; Lockwood, D.H.

    1981-01-01

    Six overweight adult subjects given a low calorie diet containing adequate amounts of nitrogen but subnormal amounts of potassium (K) were observed on the Clinical Research Center for periods of 29 to 40 days. Metabolic balance of potassium was measured together with frequent assays of total body K by 40 K counting. Metabolic K balance underestimated body K losses by 11 to 87% (average 43%): the intersubject variability is such as to preclude the use of a single correction value for unmeasured losses in K balance studies

  6. Energy balance measurement

    DEFF Research Database (Denmark)

    Dhurandhar, N V; Schoeller, D; Brown, A W

    2015-01-01

    Energy intake (EI) and physical activity energy expenditure (PAEE) are key modifiable determinants of energy balance, traditionally assessed by self-report despite its repeated demonstration of considerable inaccuracies. We argue here that it is time to move from the common view that self......-reports of EI and PAEE are imperfect, but nevertheless deserving of use, to a view commensurate with the evidence that self-reports of EI and PAEE are so poor that they are wholly unacceptable for scientific research on EI and PAEE. While new strategies for objectively determining energy balance...... of energy balance....

  7. Effektmåling ved implementering af The Balanced Scorecard på kvægsbedrifter

    DEFF Research Database (Denmark)

    Olsen, Jakob Vesterlund; Lund, Mogens

    The Balanced Scorecard is used in many firms all over the world. Literature on cre-ating a Balanced Scorecard is overwhelming. The actual benefits of implementing the Balanced Scorecard are though not that well described. In Danish Dairy farming three Balanced Scorecards have been implemented...

  8. Eccentric Exercise, Kinesiology Tape, and Balance in Healthy Men.

    Science.gov (United States)

    Hosp, Simona; Folie, Ramona; Csapo, Robert; Hasler, Michael; Nachbauer, Werner

    2017-07-01

      Deficits in balance have been identified as a possible risk factor for knee injuries in athletes. Despite a lack of evidence for its effectiveness, kinesiology tape (KT) is widely used to prevent knee injuries.   To investigate the influence of KT at the knee joint on balance ability in healthy men after eccentric exercise.   Crossover study.   University laboratory.   Twelve young men with no history of lower limb injury volunteered for the study (age = 23.3 ± 2.6 years). All participants were students enrolled in a sports science program.   Participants performed the balance test with and without KT at the knee joint on 2 separate days.   The ability to maintain balance was assessed during a single-legged-stance test using a computerized balance-stability test system. The test was performed before and after 30 minutes of downhill walking on a treadmill.   Eccentric exercise resulted in a deterioration of balance ability, which was attenuated by the use of KT. Further analyses revealed that the effectiveness of KT depended on the participant's balance status, with the preventive effect being greater in participants presenting with poorer baseline balance ability.   Applied to the knee joint, KT counteracted the exercise-related deterioration of balance ability observed when no tape was used. Participants presenting with below-average balance ability received more benefit from KT. By preventing exercise-related impairment of balance ability, KT might help to reduce the risk of sport-associated knee injuries.

  9. The Balanced Company

    DEFF Research Database (Denmark)

    in their environments. Communication specialists need to make balanced decisions which take the different value systems and assumptions of stakeholders into consideration. Change specialists need to balance the need for continuity and change. Managers need to make balanced decisions about whether to achieve goals...... that a company is respected in wider society and behaves according to ethical standards. Strategists and Leaders need to make balanced choices about long-term goals and the allocation of resources. They need to analyse, understand and adjust strategies to market, political, value and technology related changes...... is to be achieved and what should be avoided? • Through what types of processes are the criteria, conditions and values that are to be realised or taken into consideration constructed and decided upon? • What characterises the content, differences and complexity of the different types of values and criteria...

  10. National Energy Balance - 1985

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The National Energy Balance - 1985 shows energy fluxes of several primary and secondary energy sources, since the production to the final consumption in the main economic sectors, since 1974 to 1984 (E.G.) [pt

  11. In Balance With

    Directory of Open Access Journals (Sweden)

    Courtney Kessel

    2013-01-01

    Full Text Available 'In Balance With' (2012 is a live performance with Courtney Kessel and her daughter, Chloé, sitting at opposite ends of a seesaw. During the 30-minute performance, Kessel adds items representative of their lives to Chloé's side of the seesaw. After each group of items is added, she returns to her side to check the balance. Toys, violin, research books, food, pots, tools, and laundry are strapped on to the seesaw. The audience witnesses the struggle to create a balance between work, home, research, and play as a single mother and artist. As equilibrium is achieved, Kessel stills labors to maintain the balance until Chloé is ready to get down, thus signaling that her work can only happen when her daughter is cared for and occupied.

  12. The Balanced Literacy Diet.

    Science.gov (United States)

    Willows, Dale

    2002-01-01

    Describes professional development program in Ontario school district to improve student reading and writing skills. Program used food-pyramid concepts to help teacher learn to provide a balanced and flexible approach to literacy instruction based on student needs. (PKP)

  13. National Energy Balance - 1984

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The National Energy Balance - 1984 shows energy fluxes of several primary and secondary energy sources, since the productions to final consumption in the main economic sectors, since 1973 to 1983. (E.G.) [pt

  14. National Energy Balance-1987

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The National Energy Balance - 1987 showns energy fluxes of several primary and secondary energy sources, since the production to final consumption in the main economic sectors, since 1971 to 1986. (E.G.) [pt

  15. Energy balances 2000

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The energy balances of the Danish Statistical Office are the designation of the goods balances, which are tabulated for each energy article in both physical entities (quantities) and in base rates (values). The balance concept is connected to the definition supply = use, which is the basis for the construction of the system. The supply is determined as the sum of two items: import and production while the total use is the sum of 138 items: export, waste and transmission loss, stock increase, input in lack of the 130 industries, and private consumption divided into 5 consumption groups. The statistical analysis is performed yearly in both quantities and values for 35 energy articles. Values are computed for base rates, profits, taxes, VAT and market prices (buyer's price), respectively. The energy balances from 1975 to 2000 are presented for comparison. (EHS)

  16. Effectiveness of the Balanced Scorecard

    DEFF Research Database (Denmark)

    Lichen, Alex Yu; Perera, Sujatha; Crowe, Susan

    2008-01-01

    they result in more effective performance measurement systems. A survey of medium and large Australian manufacturing organisations reveals that varying forms of scorecards are used in practice and that managers who perceive that their scorecard measures are linked to strategy and affect each other in a causal......Many of the claimed benefits of the Balanced Scorecard (BSC) rely on the linkage of its performance measures to strategy and on causal relations among its measures. Using a survey research method, this study examines the extent to which adopters of BSC consider these features and whether...... manner also perceive a higher level of effectiveness of the BSC. The study also suggests that strategic use of BSC is not as widespread as might be expected....

  17. Electronics Environmental Benefits Calculator

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Electronics Environmental Benefits Calculator (EEBC) was developed to assist organizations in estimating the environmental benefits of greening their purchase,...

  18. Greenland Ice Sheet Mass Balance

    Science.gov (United States)

    Reeh, N.

    1984-01-01

    Mass balance equation for glaciers; areal distribution and ice volumes; estimates of actual mass balance; loss by calving of icebergs; hydrological budget for Greenland; and temporal variations of Greenland mass balance are examined.

  19. Ecological, biological balances and conservation

    International Nuclear Information System (INIS)

    Perttu, K.L.

    1995-01-01

    The scientific work within the activity ''ecological/biological balances and conservation'' is summarised in this report. The aims of the activity during its existence between 1992 and 1994 have been to: (i) arrange a workshop and publish the presentations on the environmental aspects of energy forest cultivations, (ii) perform joint scientific work together with the activity group on ''biological disposal of wastewaters and sludges'', that is closely related to environmental problems, and (iii) produce ecological guidelines concerning energy forestry, suitable for advisers and farmers dealing with bioenergy problems. The most important results from the workshop were the environmental benefits from energy forestry when compared with intensive agriculture and forestry. Energy forestry has positive influence on the carbon balances, nutrient recycling, and soil sustainability. The effects are also positive on the natural flora and fauna, which in most cases are enriched when compared with agricultural crops. From the joint efforts of the two activities the main result was a study tour, conference and workshop, concentrating on biological purification systems. The most promising system seems to be the vegetation filters of short rotation coppice. The report on ecological guidelines contains a number of ideas and recommendations for establishment, management, and harvesting of energy forests in an environmentally acceptable way. It also gives advice on how to locate the stands to minimise the risk of nutrient leakage from arable land. (Author)

  20. Balances instruments, manufacturers, history

    CERN Document Server

    Robens, Erich; Kiefer, Susanne

    2014-01-01

    The book deals mainly with direct mass determination by means of a conventional balances. It covers the history of the balance from the beginnings in Egypt earlier than 3000 BC to recent developments. All balance types are described with emphasis on scientific balances. Methods of indirect mass determination, which are applied to very light objects like molecules and the basic particles of matter and celestial bodies, are included.  As additional guidance, today’s manufacturers are listed and the profile of important companies is reviewed. Several hundred photographs, reproductions and drawings show instruments and their uses. This book includes commercial weighing instruments for merchandise and raw materials in workshops as well as symbolic weighing in the ancient Egyptian’s ceremony of ‘Weighing of the Heart’, the Greek fate balance, the Roman  Justitia, Juno Moneta and Middle Ages scenes of the Last Judgement with Jesus or St. Michael and of modern balances. The photographs are selected from the...

  1. ERRAPRI Project: estimation of radiation risk to patients in interventional radiology, initial results and proposed levels of complexity; Proyecto ERRAPRI: estimacion del riesgo radiologico a los pacientes en radiologia intervencionista. Primeros resultados y propuestas de indices de complejidad

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Cruces, R.; Vano, E.; Hernandez-Armas, J.; Carrera, F.; Diaz, F.; Gallego Beuther, J. F.; Ruiz Munoz-Canela, J. P.; Sanchez Casanueva, R.; Perez Martinez, M.; Fernandez Soto, J. M.; Munoz, V.; Moreno, F.; Moreno, C.; Martin-Palanca, A.

    2011-07-01

    The project ERRAPRI (2009 - 2012) will assess the most relevant aspects of the radiological risk associated with interventional radiology techniques (IR) guided by fluoroscopy in a sample of Spanish hospitals of three autonomous regions. Specific objectives include: assessing procedural protocols, especially the parameters related to radiation dose and diagnostic information obtained to establish balances cost (radiation risk) benefit to the procedures evaluated, and propose an index of complex procedures on several levels, based on the difficulty of making the same, assessing its relationship with the radiation dose values.

  2. Pesando riscos e benefícios: lições aprendidas com as intervenções terapêuticas de um caso com pré-eclâmpsia grave Balance entre beneficios y riesgos: lecciones aprendidas con las intervenciones terapéuticas de un caso con preclampsia grave Balancing the benefits and risks: lessons learned from the therapeutic interventions of a case with severe preeclampsia

    Directory of Open Access Journals (Sweden)

    Shiqin Xu

    2013-06-01

    para evitar las complicaciones cerebrales serias.BACKGROUND AND OBJECTIVE: Preeclampsia is a multiple organ dysfunction syndrome (MODS for its typical and atypical manifestations including hypertension, proteinuria, HELLP syndrome, hypertensive encephalopathy and coagulopathy. Optimal management for such patients is determined from an assessment of the balance between benefits and risks of anesthetic and obstetric therapeutic strategies. CASE REPORT: A 35-year-old pregnant woman, with one past uncomplicated pregnancy presented at 29 weeks to our medical institute as an emergency with dizziness, chest distress, palpitation, blurred vision and vaginal bleeding. After physical examination and laboratory tests, the patient was diagnosed with severe preeclampsia, HELLP syndrome, placental abruption, and MODS. The patient also presented spinal and pelvic deformity, fixation of articulus mandibularis, and tracheal displacement because of a traffic accident 11 years ago. Therefore, urgent cesarean section was performed under general anesthesia with nasal tracheal intubation using a guide wire. The patient was discharged directly home from the obstetric intensive care unit on the 7th postoperative day with normal blood pressure and full recovery of organic function. CONCLUSIONS: This case merits further discussion on the anesthesia considerations concerning how to make a clinical decision when treating such a patient. Neuraxial block is the first choice for preeclampsia patients undergoing cesarean section when a moderate but not progressive thrombocytopenia exists. When general anesthesia is decided, adequate sedation and analgesia is needed to better control the stress response to intubation especially in patients with neurological signs, and to prevent major cerebral complications.

  3. An experimental study of the ion chemistry and thermal balance in the E- and F-regions above Wallops Island

    Science.gov (United States)

    Brace, L. H.; Mayr, H. G.; Pharo, M. W., III; Scott, L. R.; Taylor, H. A., Jr.

    1971-01-01

    E and F region positive ion composition, electron concentration and thermal balance vertical profile, discussing ionizing radiation spectrum, plasma cooling, primary chemical reaction rates and ionospheric formation

  4. Watt and joule balances

    Science.gov (United States)

    Robinson, Ian A.

    2014-04-01

    The time is fast approaching when the SI unit of mass will cease to be based on a single material artefact and will instead be based upon the defined value of a fundamental constant—the Planck constant—h . This change requires that techniques exist both to determine the appropriate value to be assigned to the constant, and to measure mass in terms of the redefined unit. It is important to ensure that these techniques are accurate and reliable to allow full advantage to be taken of the stability and universality provided by the new definition and to guarantee the continuity of the world's mass measurements, which can affect the measurement of many other quantities such as energy and force. Up to now, efforts to provide the basis for such a redefinition of the kilogram were mainly concerned with resolving the discrepancies between individual implementations of the two principal techniques: the x-ray crystal density (XRCD) method [1] and the watt and joule balance methods which are the subject of this special issue. The first three papers report results from the NRC and NIST watt balance groups and the NIM joule balance group. The result from the NRC (formerly the NPL Mk II) watt balance is the first to be reported with a relative standard uncertainty below 2 × 10-8 and the NIST result has a relative standard uncertainty below 5 × 10-8. Both results are shown in figure 1 along with some previous results; the result from the NIM group is not shown on the plot but has a relative uncertainty of 8.9 × 10-6 and is consistent with all the results shown. The Consultative Committee for Mass and Related Quantities (CCM) in its meeting in 2013 produced a resolution [2] which set out the requirements for the number, type and quality of results intended to support the redefinition of the kilogram and required that there should be agreement between them. These results from NRC, NIST and the IAC may be considered to meet these requirements and are likely to be widely debated

  5. Cavendish Balance Automation

    Science.gov (United States)

    Thompson, Bryan

    2000-01-01

    This is the final report for a project carried out to modify a manual commercial Cavendish Balance for automated use in cryostat. The scope of this project was to modify an off-the-shelf manually operated Cavendish Balance to allow for automated operation for periods of hours or days in cryostat. The purpose of this modification was to allow the balance to be used in the study of effects of superconducting materials on the local gravitational field strength to determine if the strength of gravitational fields can be reduced. A Cavendish Balance was chosen because it is a fairly simple piece of equipment for measuring gravity, one the least accurately known and least understood physical constants. The principle activities that occurred under this purchase order were: (1) All the components necessary to hold and automate the Cavendish Balance in a cryostat were designed. Engineering drawings were made of custom parts to be fabricated, other off-the-shelf parts were procured; (2) Software was written in LabView to control the automation process via a stepper motor controller and stepper motor, and to collect data from the balance during testing; (3)Software was written to take the data collected from the Cavendish Balance and reduce it to give a value for the gravitational constant; (4) The components of the system were assembled and fitted to a cryostat. Also the LabView hardware including the control computer, stepper motor driver, data collection boards, and necessary cabling were assembled; and (5) The system was operated for a number of periods, data collected, and reduced to give an average value for the gravitational constant.

  6. [Cardiac effects of radiation therapy].

    Science.gov (United States)

    Tuohinen, Suvi; Turpeinen, Anu; Skyttä, Tanja; Kellokumpu-Lehtinen, Pirkko-Liisa

    2015-01-01

    Because of increased life-expentancy cancer patients having undergone radiation therapy nowadays live longer, and late-appearing adverse effects are therefore playing a more significant role. Radiation therapy given to the chest is known to approximately double the risk of heart disease, the cumulative total radiation dose being the most important risk-increasing factor. The most significant adverse effects appear only years after the treatment. The mortality from late manifestations reduces the total benefit of radiation therapy. Patients with radiation therapy due to a cancer of the left breast or Hodgkin's lymphoma are particularly susceptible to cardiac effects. A safe radiation dose is not known.

  7. Estimativa do balanço térmico por radiação em vacas Holandesas expostas ao sol e à sombra em ambiente tropical Estimate of radiation heat balance of Holstein cows in the sun and under the shade in a tropical environment

    Directory of Open Access Journals (Sweden)

    Roberto Gomes da Silva

    1999-01-01

    Full Text Available É apresentado um método para a estimativa do balanço térmico por radiação em vacas da raça Holandesa expostas ao sol e sob a sombra em uma pastagem, com o objetivo de estabelecer um padrão morfológico mais adequado para esses animais em região tropical. O método envolve a determinação das características do pelame (área de superfície de malhas negras, espessura da capa, comprimento e diâmetro dos pêlos, número de pêlos por unidade de área, temperatura da superfície da capa e da epiderme e variáveis ambientais (irradiância solar, temperatura do ar e de globo, vento. Foi determinada a quantidade de radiação de ondas curtas efetivamente transmitida através do pelame e que atinge as camadas profundas da epiderme. Demonstrou-se, por intermédio de um exemplo prático, que as áreas de pelame negro apresentaram balanço radiante mais elevado que as áreas brancas, mas estas últimas possuiam maior transmissividade para a radiação de ondas curtas. Animais predominantemente negros foram melhor protegidos contra a radiação de ondas curtas que os predominantemente brancos, especialmente quando a capa de pelame é pouco espessa (até 4 a 7 mm, mais adequada para ambientes tropicais.A method is presented to estimate the radiation heat balance of Holstein cows exposed to sun and under shade of a pasture, to contribute with a morphological characteristics better adequate for these animals in a tropical environment. The methods involved the haircoat characteristics (surface area of black spots, coat thickness, hair length, hair diameter, number of hairs per unit of area, skin and coat surface temperatures and environmental variables (solar irradiance, wind speed, air and globe temperatures. The amount of shortwave energy which effectively is transmitted through the haircoat and that reach deply the epiderms layers was obtained. It was demonstrated by a practical example that the black areas of the coat presented higher radiation

  8. Pregnancy and radiation risk

    International Nuclear Information System (INIS)

    Hadjidekova, Valeria

    2016-01-01

    Diseases of the mother during pregnancy can indicates X-ray examination for diagnosis and treatment. Radiologist and the GP should be aware of the possible damage to the fetus from radiation and to assess the actual risk and benefit of X-ray tests during pregnancy. The doses received in the uterus are small and the risk for the developing embryo or fetus is small for most diagnostic X-ray investigations. Dose of 100 mGy embryo radiation is regarded as the highest limit, above which a therapeutic abortion should be considered. The risk of radiation induced carcinogenesis exists during entire period of pregnancy. It is 2-3 times higher for developing embryo and fetus, rather than for adults. Diagnostic X-ray tests for pregnant women that are not urgent should be delayed. Keywords: radiation and pregnancy, prenatal radiation exposure, radiation fetal syndrome [bg

  9. Aposematism: balancing salience and camouflage.

    Science.gov (United States)

    Barnett, James B; Scott-Samuel, Nicholas E; Cuthill, Innes C

    2016-08-01

    Aposematic signals are often characterized by high conspicuousness. Larger and brighter signals reinforce avoidance learning, distinguish defended from palatable prey and are more easily memorized by predators. Conspicuous signalling, however, has costs: encounter rates with naive, specialized or nutritionally stressed predators are likely to increase. It has been suggested that intermediate levels of aposematic conspicuousness can evolve to balance deterrence and detectability, especially for moderately defended species. The effectiveness of such signals, however, has not yet been experimentally tested under field conditions. We used dough caterpillar-like baits to test whether reduced levels of aposematic conspicuousness can have survival benefits when predated by wild birds in natural conditions. Our results suggest that, when controlling for the number and intensity of internal contrast boundaries (stripes), a reduced-conspicuousness aposematic pattern can have a survival advantage over more conspicuous signals, as well as cryptic colours. Furthermore, we find a survival benefit from the addition of internal contrast for both high and low levels of conspicuousness. This adds ecological validity to evolutionary models of aposematic saliency and the evolution of honest signalling. © 2016 The Author(s).

  10. Radiation protection

    International Nuclear Information System (INIS)

    Koelzer, W.

    1975-01-01

    Physical and radiological terms, quantities, and units. Basic principles of radiation protection (ICRP, IAEA, EURATOM, FRG). Biological effects of ionizing radiation. Objectives of practical radiation protection. (HP) [de

  11. How Exercise Can Benefit Older Patients. A Practical Approach.

    Science.gov (United States)

    Barry, Henry C.; And Others

    1993-01-01

    Physical activity has preventive and therapeutic benefits for the frail elderly. Physicians must educate patients about exercise benefits. Walking, flexibility, and strength training can prevent muscle weakness and impaired gait and balance. Changes in functional capacity can create greater independence in daily living. Physical activity also…

  12. Interchangeability of the Wii Balance Board for Bipedal Balance Assessment

    OpenAIRE

    Bonnech?re, Bruno; Jansen, Bart; Omelina, Lubos; Rooze, Marcel; Van Sint Jan, Serge

    2015-01-01

    Background Since 2010, an increasing interest in more portable and flexible hardware for balance and posture assessment led to previously published studies determining whether or not the Wii Balance Board could be used to assess balance and posture, both scientifically and clinically. However, no previous studies aimed at comparing results from different Wii Balance Boards for clinical balance evaluation exist. Objective The objective of this crossover study is to assess the interchangeabilit...

  13. Intravenous fluids: balancing solutions.

    Science.gov (United States)

    Hoorn, Ewout J

    2017-08-01

    The topic of intravenous (IV) fluids may be regarded as "reverse nephrology", because nephrologists usually treat to remove fluids rather than to infuse them. However, because nephrology is deeply rooted in fluid, electrolyte, and acid-base balance, IV fluids belong in the realm of our specialty. The field of IV fluid therapy is in motion due to the increasing use of balanced crystalloids, partly fueled by the advent of new solutions. This review aims to capture these recent developments by critically evaluating the current evidence base. It will review both indications and complications of IV fluid therapy, including the characteristics of the currently available solutions. It will also cover the use of IV fluids in specific settings such as kidney transplantation and pediatrics. Finally, this review will address the pathogenesis of saline-induced hyperchloremic acidosis, its potential effect on outcomes, and the question if this should lead to a definitive switch to balanced solutions.

  14. Energy balance of Georgia

    Directory of Open Access Journals (Sweden)

    Demur Chomakhidze

    2016-09-01

    It is shown that, traditionally, the energy balance of Georgia is in deep deficit. The suggestions for its improvement are provided in the Article. The country imports almost all amount of oil and natural gas. Electricity balance is relatively stable. In the recent years, some amount of electricity is exported to the neighboring countries. Generally, the country satisfies only 30–35% of own energy consumption by local generation, and the rest amount of resources are imported from abroad. The reason of deficit to some extent is irrational and wasteful consumption of energy resources. The article examines the organizational difficulties in drawing up energy balance of Georgia and statistical problems of recording of energy production and consumption at the initial stage of market economy.

  15. Sport-specific balance.

    Science.gov (United States)

    Zemková, Erika

    2014-05-01

    This review includes the latest findings based on experimental studies addressing sport-specific balance, an area of research that has grown dramatically in recent years. The main objectives of this work were to investigate the postural sway response to different forms of exercise under laboratory and sport-specific conditions, to examine how this effect can vary with expertise, and to provide examples of the association of impaired balance with sport performance and/or increasing risk of injury. In doing so, sports where body balance is one of the limiting factors of performance were analyzed. While there are no significant differences in postural stability between athletes of different specializations and physically active individuals during standing in a standard upright position (e.g., bipedal stance), they have a better ability to maintain balance in specific conditions (e.g., while standing on a narrow area of support). Differences in magnitude of balance impairment after specific exercises (rebound jumps, repeated rotations, etc.) and mainly in speed of its readjustment to baseline are also observed. Besides some evidence on an association of greater postural sway with the increasing risk of injuries, there are many myths related to the negative influence of impaired balance on sport performance. Though this may be true for shooting or archery, findings have shown that in many other sports, highly skilled athletes are able to perform successfully in spite of increased postural sway. These findings may contribute to better understanding of the postural control system under various performance requirements. It may provide useful knowledge for designing training programs for specific sports.

  16. A balanced team generating model

    NARCIS (Netherlands)

    van de Water, Tara; van de Water, Henny; Bukman, Cock

    2007-01-01

    This paper introduces a general team balancing model. It first summarizes existing balancing methods. It is shown that for these methods it is difficult to meet all the conditions posed by Belbin on balanced teams. This mainly is caused by the complexity of the balancing problem. A mathematical

  17. Rotary and Magnus balances

    Science.gov (United States)

    Malcolm, G. N.

    1981-01-01

    Two wind tunnel techniques for determining part of the aerodynamic information required to describe the dynamic bahavior of various types of vehicles in flight are described. Force and moment measurements are determined with a rotary-balance apparatus in a coning motion and with a Magnus balance in a high-speed spinning motion. Coning motion is pertinent to both aircraft and missiles, and spinning is important for spin stabilized missiles. Basic principles of both techniques are described, and specific examples of each type of apparatus are presented. Typical experimental results are also discussed.

  18. Finding Your Balance

    CERN Document Server

    (CCL), Center for Creative Leadership; Patterson, Gordon

    2011-01-01

    Balance isn't an issue of time, but an issue of choice. It's about living your values by aligning your behavior with what you believe is really important. Aligning your behavior with your values is much like any other developmental experience; the basic process involves assessment, challenge, and support. You need to determine where you are, define where you want to go, and then put into place the tools you need to get there.Balance is about more than how you spend your time. It's about how you live your life. It's about recognizing that you have control over the choices you make and aligning

  19. Application of Balanced Scorecard

    OpenAIRE

    Langpaulová, Irena

    2011-01-01

    The concept of the Balanced Scorecard taking a part in the strategic management of a company, is a main focus of this thesis. There are the theoretical and methodological parts of the Balanced Scorecard characterized individually, as well as the development and the history of this concept. This thesis is dealing with a draft of the practical implementation of the mentioned methods. The practical part of the thesis is following the theoretical introduction where the practical part is focused o...

  20. Yin-Yang Balancing

    DEFF Research Database (Denmark)

    Li, Peter Ping

    The potential contribution of the Eastern frame of Yin-Yang Balancing lies in the mindset of "either/and", in contrast to Aristotle's either/or logic and Hegel's "both/or". Implications of this either/and thinking for science and management will be explored.......The potential contribution of the Eastern frame of Yin-Yang Balancing lies in the mindset of "either/and", in contrast to Aristotle's either/or logic and Hegel's "both/or". Implications of this either/and thinking for science and management will be explored....

  1. In the balance

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    The present paper seeks to make sense of recent EU naval capability changes by applying neo-realist theory on the EU as an international actor in the global balance of power. The paper compares three different strands of Neo-realist theory by deducting key predictions about the expected defense...... posture of the Union and the expected changes in naval capabilities. The predictions are subsequently held up against recent data on naval military build-up in the EU. The paper argues that the observed patterns are best explained not as bandwagoning with the United States, but as a long-term balancing...

  2. Greenhouse Effect, Radiative Forcing and Climate Sensitivity

    Science.gov (United States)

    Ponater, Michael; Dietmüller, Simone; Sausen, Robert

    Temperature conditions and climate on Earth are controlled by the balance between absorbed solar radiation and outgoing terrestrial radiation. The greenhouse effect is a synonym for the trapping of infrared radiation by radiatively active atmospheric constituents. It generally causes a warming of the planet's surface, compared to the case without atmosphere. Perturbing the radiation balance of the planet, e.g., by anthropogenic greenhouse gas emissions, induces climate change. Individual contributions to a total climate impact are usually quantified and ranked in terms of their respective radiative forcing. This method involves some limitations, because the effect of the external forcing is modified by radiative feedbacks. Here the current concept of radiative forcing and potential improvements are explained.

  3. Net radiation of mountain cultivated Norway spruce [Picea abies (L.) Karst.] stand: evaluation of shortand long-wave radiation ratio

    OpenAIRE

    Marková, Irena; Marek, Michal V.

    2011-01-01

    The radiation exchange drives the plant ecosystems energy balance and provides the energy for photosynthesis, transpiration and plant growth. The investigation on net radiation and its component during vegetation season in relation to the clearness index and sun elevation in a cultivated 31-year-old mountain spruce [Picea abies (L.) Karst.] stand is presented. Downward short-wave radiation – Sd (incident on the spruce stand was the main part of the short-wave radiation balance during th...

  4. Radiation enteritis

    Science.gov (United States)

    Radiation enteropathy; Radiation-induced small bowel injury; Post-radiation enteritis ... Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells. The therapy ...

  5. Social costs and benefits of nuclear futures

    International Nuclear Information System (INIS)

    Pearce, D.

    1979-01-01

    The conceptual framework for evaluating which energy path is chosen is one of trading-off costs and benefits in a world of technological, economic and social uncertainty. The translation of this conceptual framework into an analytical format with empirical relevance is dealt with. Some salient features of cost benefit analysis are discussed. Actual costs and benefits of nuclear futures are then considered. Subjects discussed are: routine and non-routine radiation, waste management, proliferation, and civil liberties. A 'regret' matrix is presented showing the cost to any future generation if a decision on nuclear power is made now. (U.K.)

  6. A new diagram of the global energy balance

    Science.gov (United States)

    Wild, Martin; Folini, Doris; Schär, Christoph; Loeb, Norman; Dutton, Ellsworth G.; König-Langlo, Gert

    2013-05-01

    Here we provide a new assessment of the global mean energy fluxes from a surface perspective and present an associated diagram of the global mean energy balance, adapted from the study by Wild et al. (2013) [1] with two slight modifications as outlined in this paper. The radiative energy exchanges between Sun, Earth and space are now accurately quantified from new satellite missions. Much less has been known about the magnitude of the energy flows within the climate system and at the Earth surface, which cannot be directly measured by satellites. In addition to satellite observations, we make extensive use of the growing number of surface observations to constrain the global energy balance not only from space, but also from the surface. We combine these observations with the latest modeling efforts performed for the 5th IPCC assessment report to infer best estimates for the global mean surface radiative components. Our analyses favor global mean downward surface solar and thermal radiation values near 185 and 342 Wm-2, respectively, which are most compatible with surface observations. Combined with an estimated surface absorbed solar radiation and thermal emission of 161 Wm-2 and 398 Wm-2, respectively, this leaves 105 Wm-2 of surface net radiation available for distribution amongst the non-radiative surface energy balance components. Considering an imbalance of 0.6 Wm-2, the global mean sensible and latent heat fluxes are estimated at 20 and 84 Wm-2, respectively, to close the surface energy balance. The global mean surface radiative fluxes derived here in combination with a latent heat flux of 84 Wm-2 may be able to reconcile currently disputed inconsistencies between energy and water cycle estimates. The findings of this study are compiled into a new global energy balance diagram.

  7. Radiation biology

    International Nuclear Information System (INIS)

    Neumeister, K.

    1977-01-01

    This chapter is included in a textbook which is primarily intended for medical students. The following topics are dealt with: radiation effects on molecules; chemical and biochemical radiation effects; modification of radiation effects and radiosensitivity; radiation-induced pathomorphological and pathophysiological effects in organs and organ systems; radiation syndrome; radiation effects in embryos and fetuses; genetic radiation effects; carcinogenesis and leukemogenesis after irradiation; and radiation effects after intake of radionuclides

  8. National energy balance - 1977

    International Nuclear Information System (INIS)

    1977-01-01

    The national energy balance of the 1976 shows several modifications in relation to the last year. The historical serie is based in more confiable information, from several energy companies. The most greater modifications are on energy source of hard control, such as lignite and charcoal for non-siderurgic uses. (E.G.) [pt

  9. National energy balance - 1978

    International Nuclear Information System (INIS)

    1978-01-01

    The national energy balance of 1978 shows some modifications in relation to the last year. New tables were included aiming to show the brazilian energy situation, such as the hydraulic potential and the non-renewable energy resources. (E.G.) [pt

  10. Frihed, anerkendelse og balance

    DEFF Research Database (Denmark)

    Anker, Thomas Boysen

    2008-01-01

    Artiklen argumenterer for, at selv ikke den absolut mest familievenlige arbejdsplads vil kunne løse det psykologiske problem med at skabe balance mellem familie og arbejdsliv, fordi ubalancen grundlæggende handler om en anerkendelseskonflikt, som individet ikke altid selv er interesseret i at komme...

  11. Load Balancing in Hypergraphs

    Science.gov (United States)

    Delgosha, Payam; Anantharam, Venkat

    2018-03-01

    Consider a simple locally finite hypergraph on a countable vertex set, where each edge represents one unit of load which should be distributed among the vertices defining the edge. An allocation of load is called balanced if load cannot be moved from a vertex to another that is carrying less load. We analyze the properties of balanced allocations of load. We extend the concept of balancedness from finite hypergraphs to their local weak limits in the sense of Benjamini and Schramm (Electron J Probab 6(23):13, 2001) and Aldous and Steele (in: Probability on discrete structures. Springer, Berlin, pp 1-72, 2004). To do this, we define a notion of unimodularity for hypergraphs which could be considered an extension of unimodularity in graphs. We give a variational formula for the balanced load distribution and, in particular, we characterize it in the special case of unimodular hypergraph Galton-Watson processes. Moreover, we prove the convergence of the maximum load under some conditions. Our work is an extension to hypergraphs of Anantharam and Salez (Ann Appl Probab 26(1):305-327, 2016), which considered load balancing in graphs, and is aimed at more comprehensively resolving conjectures of Hajek (IEEE Trans Inf Theory 36(6):1398-1414, 1990).

  12. Maintaining an Environmental Balance

    Science.gov (United States)

    Environmental Science and Technology, 1976

    1976-01-01

    A recent conference of the National Environmental Development Association focused on the concepts of environment, energy and economy and underscored the necessity for balancing the critical needs embodied in these issues. Topics discussed included: nuclear energy and wastes, water pollution control, federal regulations, environmental technology…

  13. National Energy Balance - 1986

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The National Energy Balance - 1986 shows energy fluxes of several primary and secondary energy sources, since the production to the final consumption in the main economic sectors, since 1970 to 1985. The incorporation of a new brazilian information is done. (E.G.) [pt

  14. Balance of Power

    NARCIS (Netherlands)

    Boone, J.

    2004-01-01

    This paper argues that the efficiency distribution of players in a game determines how aggressively these players interact.We formalize the idea of balance of power: players fight very inefficient players but play softly versus equally (or more) efficient players.This theory of conduct predicts that

  15. Yin-Yang Balancing

    DEFF Research Database (Denmark)

    Li, Peter Ping

    The potential contribution of the Eastern frame of Yin-Yang Balancing lies in the mindset of "either/and", in contrast to Aristotle's either/or logic and Hegel's "both/or". Implications of this either/and thinking for science and management will be explored....

  16. National Energy Balance - 1981

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    The National Energy Balance - 1981, shows a new metodology and information in level of several economic sectors, as well as a separation of primary and secondary energy sources, its energy fluxes, i.e. production, imports, exports, consumption, etc...(E.G.) [pt

  17. Interchangeability of the Wii Balance Board for Bipedal Balance Assessment

    Science.gov (United States)

    Jansen, Bart; Omelina, Lubos; Rooze, Marcel; Van Sint Jan, Serge

    2015-01-01

    Background Since 2010, an increasing interest in more portable and flexible hardware for balance and posture assessment led to previously published studies determining whether or not the Wii Balance Board could be used to assess balance and posture, both scientifically and clinically. However, no previous studies aimed at comparing results from different Wii Balance Boards for clinical balance evaluation exist. Objective The objective of this crossover study is to assess the interchangeability of the Wii Balance Board. Methods A total of 6 subjects participated in the study and their balance was assessed using 4 different Wii Balance Boards. Trials were recorded simultaneously with Wii Balance Boards and with a laboratory force plate. Nine relevant clinical parameters were derived from center of pressure displacement data obtained from Wii Balance Board and force plate systems. Intraclass correlation coefficients (ICC), F tests, and Friedman tests were computed to assess the agreement between trials and to compare the Wii Balance Board and force plate results. Results Excellent correlations were found between the Wii Balance Board and force plate (mean ρ =.83). With the exception of 2 parameters, strong to excellent agreements were found for the 7 remaining parameters (ICC=.96). No significant differences were found between trials recorded with different Wii Balance Boards. Conclusions Our results indicate that for most of the parameters analyzed, balance and posture assessed with one Wii Balance Board were statistically similar to results obtained from another. Furthermore, the good correlation between the Wii Balance Board and force plate results shows that Wii Balance Boards can be reliably used for scientific assessment using most of the parameters analyzed in this study. These results also suggest that the Wii Balance Board could be used in multicenter studies and therefore, would allow for the creation of larger populations for clinical studies. Trial

  18. Employee motivation and benefits

    OpenAIRE

    Březíková, Tereza

    2009-01-01

    The topic of my bachelor's thesis is the employee motivation and benefits. The thesis is divided in two parts, a theoretical one and a practical one. The theoretical part deals with the theory of motivation and individual employee benefits. The practical part describes employee benefits in ČSOB, where I did my research by questionnaires that were filled in by employees from different departments of ČSOB. These employees answered questions about their work motivation and benefits. The resultts...

  19. Analysis of benefits

    OpenAIRE

    Kováříková, Kamila

    2012-01-01

    This master thesis deals with employee benefits in the current labour market, especially from the perspective of young employees. The first part is focused on the theory of motivation and employee benefits also with their tax impact on employee's income. Employee benefits in the current labour market, employee's satisfaction and employer's attitude to this issue are analyzed in the second part of this thesis.

  20. iBEST: intelligent Balance assessment and Stability Training system using smartphone.

    Science.gov (United States)

    Wai, Aung Aung Phyo; Duc, Pham Duy; Syin, Chan; Zhang, Haihong

    2014-01-01

    Patients with postural instability could lead to falls and injuries while walking due to balance disorders. So those patients need regular balance training and evaluation to improve and examine balance deficiencies. But many do not notice such balance issues; resulting lack of timely preventive measures. This shows the needs of affordable and accessible solution for balance training and assessment. So iBEST (intelligent Balance assessment and Stability Training) is proposed enabling to train and assess balance conveniently anywhere anytime. Moreover, therapists can remotely evaluate and manage their recovery progress. These benefits can be realized leveraging sensors from smartphone, cloud-based data analytics and web applications. iBEST employs sensorised automated balance assessment in digitizing Berg Balance Scale (BBS) clinical risk assessment tool. The initial feasibility study showed average accuracy of 90.22% using smartphone in classifying the specified BBS test items.

  1. Balancing with vibration: a prelude for "drift and act" balance control.

    Directory of Open Access Journals (Sweden)

    John G Milton

    Full Text Available Stick balancing at the fingertip is a powerful paradigm for the study of the control of human balance. Here we show that the mean stick balancing time is increased by about two-fold when a subject stands on a vibrating platform that produces vertical vibrations at the fingertip (0.001 m, 15-50 Hz. High speed motion capture measurements in three dimensions demonstrate that vibration does not shorten the neural latency for stick balancing or change the distribution of the changes in speed made by the fingertip during stick balancing, but does decrease the amplitude of the fluctuations in the relative positions of the fingertip and the tip of the stick in the horizontal plane, A(x,y. The findings are interpreted in terms of a time-delayed "drift and act" control mechanism in which controlling movements are made only when controlled variables exceed a threshold, i.e. the stick survival time measures the time to cross a threshold. The amplitude of the oscillations produced by this mechanism can be decreased by parametric excitation. It is shown that a plot of the logarithm of the vibration-induced increase in stick balancing skill, a measure of the mean first passage time, versus the standard deviation of the A(x,y fluctuations, a measure of the distance to the threshold, is linear as expected for the times to cross a threshold in a stochastic dynamical system. These observations suggest that the balanced state represents a complex time-dependent state which is situated in a basin of attraction that is of the same order of size. The fact that vibration amplitude can benefit balance control raises the possibility of minimizing risk of falling through appropriate changes in the design of footwear and roughness of the walking surfaces.

  2. Nuclear medicine radiation dosimetry

    CERN Document Server

    McParland, Brian J

    2010-01-01

    Complexities of the requirements for accurate radiation dosimetry evaluation in both diagnostic and therapeutic nuclear medicine (including PET) have grown over the past decade. This is due primarily to four factors: growing consideration of accurate patient-specific treatment planning for radionuclide therapy as a means of improving the therapeutic benefit, development of more realistic anthropomorphic phantoms and their use in estimating radiation transport and dosimetry in patients, design and use of advanced Monte Carlo algorithms in calculating the above-mentioned radiation transport and

  3. Radiation and waste safety

    International Nuclear Information System (INIS)

    1997-01-01

    Most of the ionizing radiation that people are exposed to in day-to-day activities comes from natural, rather than manmade, sources. Nuclear radiation is a powerful source of benefit to mankind, whether applied in the field of medicine, agriculture, environmental management or elsewhere. The health effects of radiation - both natural and artificial - are relatively well understood and can be minimized through careful safety measures and practices. The Department of Technical Co-operation is sponsoring a programme with the support of the Nuclear Safety Department aiming at establishing Basic Safety Standard requirements in all Member States. (IAEA)

  4. Radiation protection - the unions

    International Nuclear Information System (INIS)

    Jacques, P.

    1983-01-01

    A brief report is given of a paper presented at the symposium on 'Radiation and the Worker - where do we go from here' in London 1983. The paper concerned trade union viewpoints on the draft of the proposed Ionising Radiations Regulations in the Health and Safety Commission Consultative Document. The main contentious issue was that the 5 rem dose limit might have been lower if ICRP had agreed to involve employers and the trade union movement in their considerations. However, it was concluded that, on balance, the trade union movement would welcome the proposed Regulations. (U.K.)

  5. Implications of albedo changes following afforestation on the benefits of forests as carbon sinks

    Directory of Open Access Journals (Sweden)

    M. U. F. Kirschbaum

    2011-12-01

    Full Text Available Increased carbon storage with afforestation leads to a decrease in atmospheric carbon dioxide concentration and thus decreases radiative forcing and cools the Earth. However, afforestation also changes the reflective properties of the surface vegetation from more reflective pasture to relatively less reflective forest cover. This increase in radiation absorption by the forest constitutes an increase in radiative forcing, with a warming effect. The net effect of decreased albedo and carbon storage on radiative forcing depends on the relative magnitude of these two opposing processes.

    We used data from an intensively studied site in New Zealand's Central North Island that has long-term, ground-based measurements of albedo over the full short-wave spectrum from a developing Pinus radiata forest. Data from this site were supplemented with satellite-derived albedo estimates from New Zealand pastures. The albedo of a well-established forest was measured as 13 % and pasture albedo as 20 %. We used these data to calculate the direct radiative forcing effect of changing albedo as the forest grew.

    We calculated the radiative forcing resulting from the removal of carbon from the atmosphere as a decrease in radiative forcing of −104 GJ tC−1 yr−1. We also showed that the observed change in albedo constituted a direct radiative forcing of 2759 GJ ha−1 yr−1. Thus, following afforestation, 26.5 tC ha−1 needs to be stored in a growing forest to balance the increase in radiative forcing resulting from the observed albedo change. Measurements of tree biomass and albedo were used to estimate the net change in radiative forcing as the newly planted forest grew. Albedo and carbon-storage effects were of similar magnitude for the first four to five years after tree planting, but as the stand grew older, the carbon storage effect increasingly dominated. Averaged over the whole

  6. Surface Energy Balance System (SEBS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    A Surface Energy Balance System (SEBS) has been installed collocated with each deployed Eddy Correlation Flux Measurement System (ECOR) at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, North Slope of Alaska (NSA) site, first ARM Mobile Facility (AMF1), second ARM Mobile Facility (AMF2), and third ARM Mobile Facility (AMF3) at Oliktok Point (OLI). A SEBS was also deployed with the Tropical Western Pacific (TWP) site, before it was decommissioned. Data from these sites, including the retired TWP, are available in the ARM Data Archive. The SEBS consists of upwelling and downwelling solar and infrared radiometers within one net radiometer, a wetness sensor, and soil measurements. The SEBS measurements allow the comparison of ECOR sensible and latent heat fluxes with the energy balance determined from the SEBS and provide information on wetting of the sensors for data quality purposes.

  7. Balancing trust and power

    DEFF Research Database (Denmark)

    Broholm-Jørgensen, Marie; Guassora, Ann Dorrit; Reventlow, Susanne

    2017-01-01

    Objective: Little is known about how strategies of retaining patients are acted out by general practitioners (GPs) in the clinical encounter. With this study, we apply Grimens’ (2009) analytical connection between trust and power to explore how trust and power appear in preventive health checks...... from the GPs’ perspectives, and in what way trust and power affect and/or challenge strategies towards retaining patients without formal education. Design: Data in this study were obtained through semi-structured interviews with GPs participating in an intervention project, as well as observations...... of power in the encounter. The GPs articulated that a balance was needed in preventive health checks in order to establish trust and thus retain the patient in the clinic. One way this balance of respect was carried out was with the use of humour. Conclusions: To retain patients without formal education...

  8. Lunar Balance and Locomotion

    Science.gov (United States)

    Paloski, William H.

    2008-01-01

    Balance control and locomotor patterns were altered in Apollo crewmembers on the lunar surface, owing, presumably, to a combination of sensory-motor adaptation during transit and lunar surface operations, decreased environmental affordances associated with the reduced gravity, and restricted joint mobility as well as altered center-of-gravity caused by the EVA pressure suits. Dr. Paloski will discuss these factors, as well as the potential human and mission impacts of falls and malcoordination during planned lunar sortie and outpost missions. Learning objectives: What are the potential impacts of postural instabilities on the lunar surface? CME question: What factors affect balance control and gait stability on the moon? Answer: Sensory-motor adaptation to the lunar environment, reduced mechanical and visual affordances, and altered biomechanics caused by the EVA suit.

  9. Life Balancing -- A Better Way to Balance Large Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R. Dyche; Zane, Regan; Plett, Gregory; Maksimovic, Dragan; Smith, Kandler; Trimboli, M. Scott

    2017-03-28

    A new cell balancing technology was developed under a Department of Energy contract which merges the DC/DC converter function into cell balancing. Instead of conventional passive cell balancing technology which bypasses current through a resistor, or active cell balancing which moves current from one cell to another, with significant cost and additional inefficiencies, this concept takes variable amount of current from each cell or small group of cells and converts it to current for the low voltage system.

  10. National energy balance - 1976

    International Nuclear Information System (INIS)

    1976-01-01

    Based on available data from IBGE, CNP/Petrobras, Eletrobras, Nuclebras and other governmental enterprises the National Energy Balance was done. This publication covers since 1965 to 1975. In conformity to the international rules, the energy resources used for non-energy purposes were excluded. The energy production and consumption for the next ten years were forecasted, considering the actual brazilian energy policy. (E.G.) [pt

  11. Radiation safety, protection and recommendations in dentistry - a review

    International Nuclear Information System (INIS)

    Castelino, Renita

    2013-01-01

    Radiation is the transmission of energy through space and matter. Diagnostic radiology uses ionizing radiations which have sufficient energy to ionize atoms or molecules in biological and other systems. X-rays used in diagnostic radiology are a potent mutagenic agent, capable of inducing both gene mutations and chromosomal aberrations. X-rays are extensively used in medical and dental practice for the purpose of diagnosis and treatment. X-rays provide useful information and aid in diagnosis but at the same time they also have the potential to cause harmful effects. In dentistry X-rays are used mainly for diagnosis. Radiation in doses required for dentistry may not present any major risks, however these small doses are not necessarily risk free. Hence, no exposure to X-rays can be considered completely free of risk, so the use of radiation by dentists is accompanied by a responsibility to ensure appropriate protection. Several radiation safety measures have been recommended and advocated to reduce harmful effects. Dental professionals are the only practitioners who perform radiographical examination of their patients themselves. Although the exposure used in dentistry is low every effort should be made to reduce radiation in order to prevent the accumulated dose to the dentist in their lifetime. The dose reduction can be achieved in three main steps. They are decision making, optimising radiologic procedures and patient protection. The potential for undesirable effects must be balanced against the benefits obtained from radiographs. Therefore, the aim of the paper is to review important parameters that must be taken into consideration in the clinical set up to reduce radiation exposure to patients and dental personnel. (author)

  12. Implementace metody Balanced Scorecard

    OpenAIRE

    Neuwirth, Pavel

    2014-01-01

    Diplomová práce je zaměřena na hodnocení výkonnosti společnosti pomocí metody Balanced Scorecard. Teoretická část práce popisuje východiska měření výkonnosti, metody Balanced Scorecard a postup při její implementaci. Analytická část vychází z teoretických poznatků z první části a hodnotí situaci společnosti finanční analýzou poměrových ukazatelů, strategickou analýzou a následným sestavením návrhu implementace metody Balanced Scorecard v konkrétní společnosti. Thesis is focused on evaluati...

  13. Simple Cell Balance Circuit

    Science.gov (United States)

    Johnson, Steven D.; Byers, Jerry W.; Martin, James A.

    2012-01-01

    A method has been developed for continuous cell voltage balancing for rechargeable batteries (e.g. lithium ion batteries). A resistor divider chain is provided that generates a set of voltages representing the ideal cell voltage (the voltage of each cell should be as if the cells were perfectly balanced). An operational amplifier circuit with an added current buffer stage generates the ideal voltage with a very high degree of accuracy, using the concept of negative feedback. The ideal voltages are each connected to the corresponding cell through a current- limiting resistance. Over time, having the cell connected to the ideal voltage provides a balancing current that moves the cell voltage very close to that ideal level. In effect, it adjusts the current of each cell during charging, discharging, and standby periods to force the cell voltages to be equal to the ideal voltages generated by the resistor divider. The device also includes solid-state switches that disconnect the circuit from the battery so that it will not discharge the battery during storage. This solution requires relatively few parts and is, therefore, of lower cost and of increased reliability due to the fewer failure modes. Additionally, this design uses very little power. A preliminary model predicts a power usage of 0.18 W for an 8-cell battery. This approach is applicable to a wide range of battery capacities and voltages.

  14. Can the Power Balance® Bracelet Improve Balance, Flexibility, Strength, and Power?

    OpenAIRE

    Porcari, John; Hazuga, Rachel; Foster, Carl; Doberstein, Scott; Becker, Jordan; Kline, Dennis; Mickschl, Thomas; Dodge, Chris

    2011-01-01

    Athletes are constantly searching for something that will give them a competitive edge. Performance jewelry is one of the latest products on the market designed to improve athletic performance. The most common claims are that wearing this performance jewelry will improve flexibility, balance, and strength. There is considerable marketing of these products, including testimonial evidence by high profile athletes, in support of the purported benefits. In demonstrations designed to validate the ...

  15. Radiation protection in medical applications

    International Nuclear Information System (INIS)

    Maldonado M, H.

    2008-12-01

    country wish to fulfill the commitment to meet the current needs in medicine, with a favorable balance of benefits and achieving excellence in harnessing of the atom energy. (Author)

  16. Radiation risk education program - local

    International Nuclear Information System (INIS)

    Bushong, S.C.; Archer, B.R.

    1980-01-01

    This article points out the lack of knowledge by the general public and medical profession concerning the true risks of radiation exposure. The author describes an educational program which can be implemented at the local level to overcome this deficiency. The public must understand the enormous extent of benefit derived from radiation applications in our society

  17. Energy Balance Bowen Ratio Station (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, DR

    2011-02-23

    The energy balance Bowen ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  18. Energy Balance Bowen Ratio (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    The Energy Balance Bowen Ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  19. Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury

    OpenAIRE

    Gil-Gómez, José-Antonio; Lloréns, Roberto; Alcañiz, Mariano; Colomer, Carolina

    2011-01-01

    Background: Acquired brain injury (ABI) is the main cause of death and disability among young adults. In most cases, survivors can experience balance instability, resulting in functional impairments that are associated with diminished health-related quality of life. Traditional rehabilitation therapy may be tedious. This can reduce motivation and adherence to the treatment and thus provide a limited benefit to patients with balance disorders. We present eBaViR (easy Balance Virtual Rehabilita...

  20. Cardiac imaging: does radiation matter?

    OpenAIRE

    Einstein, Andrew J.; Knuuti, Juhani

    2011-01-01

    The use of ionizing radiation in cardiovascular imaging has generated considerable discussion. Radiation should not be considered in isolation, but rather in the context of a careful examination of the benefits, risks, and costs of cardiovascular imaging. Such consideration requires an understanding of some fundamental aspects of the biology, physics, epidemiology, and terminology germane to radiation, as well as principles of radiological protection. This paper offers a concise, contemporary...

  1. Analysis of Employee Benefits

    OpenAIRE

    Burešová, Lenka

    2013-01-01

    The target of this bachelor thesis is to analyze employee benefits from the perspective of employees and to employers suggest possible ideas to improve their provision. The work is divided into two parts: theoretical and practical. The theoretical part describes the overal remuneration of employees, payroll system and employee benefits. Benefits are included in the remuneration system, broken and some of them are defined. The practical part presents a survey among employees in the Czech Repub...

  2. Transit Benefit Program Data -

    Data.gov (United States)

    Department of Transportation — This data set contains information about any US government agency participating in the transit benefits program, funding agreements, individual participating Federal...

  3. CERES Energy Balanced and Filled(EBAF) Surface Monthly means data in netCDF

    Data.gov (United States)

    National Aeronautics and Space Administration — The Clouds and the Earth's Radiant Energy System (CERES) Energy Balanced and Filled (EBAF) Surface product provides computed monthly mean surface radiative fluxes...

  4. Hallux Valgus Surgery May Produce Early Improvements in Balance Control

    Science.gov (United States)

    Sadra, Saba; Fleischer, Adam; Klein, Erin; Grewal, Gurtej S.; Knight, Jessica; Weil, Lowell Scott; Weil, Lowell; Najafi, Bijan

    2016-01-01

    Background Hallux valgus (HV) is associated with poorer performance during gait and balance tasks and is an independent risk factor for falls in older adults. We sought to assess whether corrective HV surgery improves gait and balance. Methods Using a cross-sectional study design, gait and static balance data were obtained from 40 adults: 19 patients with HV only (preoperative group), 10 patients who recently underwent successful HV surgery (postoperative group), and 11 control participants. Assessments were made in the clinic using body-worn sensors. Results Patients in the preoperative group generally demonstrated poorer static balance control compared with the other two groups. Despite similar age and body mass index, postoperative patients exhibited 29% and 63% less center of mass sway than preoperative patients during double- and single-support balance assessments, respectively (analysis of variance P =.17 and P =.14, respectively [both eyes open condition]). Overall, gait performance was similar among the groups, except for speed during gait initiation, where lower speeds were encountered in the postoperative group compared with the preoperative group (Scheffe P = .049). Conclusions This study provides supportive evidence regarding the benefits of corrective lower-extremity surgery on certain aspects of balance control. Patients seem to demonstrate early improvements in static balance after corrective HV surgery, whereas gait improvements may require a longer recovery time. Further research using a longitudinal study design and a larger sample size capable of assessing the long-term effects of HV surgical correction on balance and gait is probably warranted. PMID:24297985

  5. Radiation monitor

    International Nuclear Information System (INIS)

    Pao, C.T.; Green, W.K.

    1978-01-01

    A system for indicating radiation from a radioactive fluid such as a gas wherein simultaneous indications of the activity concentration of radioactivity of the gas, the radiation dose rate and average energy of the radiation are provided

  6. Radiation protection

    International Nuclear Information System (INIS)

    Ures Pantazi, M.

    1994-01-01

    This work define procedures and controls about ionizing radiations. Between some definitions it found the following topics: radiation dose, risk, biological effects, international radioprotection bodies, workers exposure, accidental exposure, emergencies and radiation protection

  7. X-ray diagnostics - benefits and risks; Roentgendiagnostik - Nutzen und Risiken

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomaeus, Melanie (comp.)

    2016-10-15

    The brochure on benefits and risks of X-ray diagnostics discusses the following issues: X radiation - a pioneering discovery and medical sensation, fundamentals of X radiation, frequency of X-ray examinations in Germany in relation to CT imaging, radiation doses resulting from X-ray diagnostics, benefits of X-ray diagnostics - indication and examples, risks - measures for radiation exposure reductions, avoidance of unnecessary examinations.

  8. Lesson "Balance in Nature

    Science.gov (United States)

    Chapanova, V.

    2012-04-01

    Lesson "Balance in Nature" This simulation game-lesson (Balance in Nature) gives an opportunity for the students to show creativity, work independently, and to create models and ideas. It creates future-oriented thought connected to their experience, allowing them to propose solutions for global problems and personal responsibility for their activities. The class is divided in two teams. Each team chooses questions. 1. Question: Pollution in the environment. 2. Question: Care for nature and climate. The teams work on the chosen tasks. They make drafts, notes and formulate their solutions on small pieces of paper, explaining the impact on nature and society. They express their points of view using many different opinions. This generates alternative thoughts and results in creative solutions. With the new knowledge and positive behaviour defined, everybody realizes that they can do something positive towards nature and climate problems and the importance of individuals for solving global problems is evident. Our main goal is to recover the ecological balance, and everybody explains his or her own well-grounded opinions. In this work process the students obtain knowledge, skills and more responsible behaviour. This process, based on his or her own experience, dialogue and teamwork, helps the participant's self-development. Making the model "human↔ nature" expresses how human activities impact the natural Earth and how these impacts in turn affect society. Taking personal responsibility, we can reduce global warming and help the Earth. By helping nature we help ourselves. Teacher: Veselina Boycheva-Chapanova " Saint Patriarch Evtimii" Scholl Str. "Ivan Vazov"-19 Plovdiv Bulgaria

  9. Strategic Balanced Scorecard Simulation

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Erland Hejn

    2012-01-01

    of financial and non-financial measures. The overall idea of BSC is to make the strategy operational, as proposed by Kaplan and Norton (1992; 1996; 2007) and to use the strategy for simulation. Our results indicate that a company may gain great learning insight from such simulation studies. The whole article......The purpose of this article is to show how a System Dynamics Modelling approach can be integrated into the Balanced Scorecard (BSC) for a case company with special focus on the handling of causality in a dynamic perspective. The case company’s BSC model includes five perspectives and a number...

  10. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    This paper focuses on the leadership challenge of balancing trust and control. The relation between trust and control has for a long time been a puzzling issue for management researchers. In the paper I first show that there has been a dramatic change in the way the relation between trust....... The paper concludes by illustrating how this more fine grained understanding of the intertwining of trust and control is helpful for the understanding of the interplay of trust, control and self-control in new forms of organizations....

  11. Energy balances 2005

    International Nuclear Information System (INIS)

    Anon.

    2006-01-01

    Denmark's energy consumption was 800 PJ in 2005 when corrected for the fuel consumption used for producing electricity for export. The consumption is 0,5 % higher than in 2004. Since 1975, the energy consumption has been on the same level with minor fluctuations which are mainly due to the climate. The energy balances is an account of production, import and export, and consumption of energy. The consumption is accounted as physical amounts as well as gross consumption. Also, accounts are presented of the costs of energy in basis prices and in market prices, including excises on energy, CO 2 , and SO 2 . (LN)

  12. Ballet Balance Strategies

    DEFF Research Database (Denmark)

    Pedersen, Camilla; Erleben, Kenny; Sporring, Jon

    2006-01-01

    Animating physically realistic human characters is challenging, since human observers are highly tuned to recognize human cues such as emotion and gender from motion patterns. The main contribution of this paper is a new model firmly based on biomechanics, which is used to animate balance and basic...... movements of a ballet dancers. It is supported by computer simulated experiments and it is in good agreement with biomechanical measurements of real-life dancers. Our results questions the previous approaches in dynamic animation, which only uses the center of gravity strategy, and instead demonstrate...

  13. Balancing beyond the horizon?

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    2011-01-01

    The present article seeks to make sense of recent European Union (EU) naval capability changes by applying neo-realist theory to the EU as a collective actor in the global balance of power. The paper compares two different strands of neorealist theory by deducing key predictions about the expected...... naval posture of the Union and the corresponding expected changes in capabilities. These predictions are subsequently held up against post-cold war data on naval acquisitions in the EU. The paper concludes that the observed patterns are best explained not as bandwagoning with the USA, but as a long...

  14. Balancing through episodic learning

    DEFF Research Database (Denmark)

    Scheuer, John Damm

    2013-01-01

    Peter Jarvis’s theory about learning suggests that human beings learn and change as a result of hearing, seeing, smelling, tasting, touching, and feeling. They change and learn by interacting with other humans, things, and events in certain time-space contexts and by reflecting upon these, as well...... as upon wished-for future states or past experiences, knowledge, and history, and upon what these experiences mean to one’s own self and identity. This chapter explores how female top managers have to reflect and find a balance in their work-family lives on the basis of interaction with, and inputs from...

  15. Ionizing radiation

    International Nuclear Information System (INIS)

    Kruger, J.

    1989-01-01

    Ionizing radiation results in biological damage that differs from other hazardous substances and is highly dangerous to man. Ionizing radiation cannot be perceived by man's sense organs and the biological damage cannot be detected immediately afterwards (except in very high doses). Every human being is exposed to low doses of radiation. The structure of the atom; sources of ionizing radiation; radiation units; biological effects; norms for radiation protection; and the national control in South Africa are discussed. 1 fig., 5 refs

  16. Radiation dosimetry

    CERN Document Server

    Hine, Gerald J; Hine, Gerald J

    1956-01-01

    Radiation Dosimetry focuses on the advancements, processes, technologies, techniques, and principles involved in radiation dosimetry, including counters and calibration and standardization techniques. The selection first offers information on radiation units and the theory of ionization dosimetry and interaction of radiation with matter. Topics include quantities derivable from roentgens, determination of dose in roentgens, ionization dosimetry of high-energy photons and corpuscular radiations, and heavy charged particles. The text then examines the biological and medical effects of radiation,

  17. Effects of dynamic posturographic balance training versus conventional balance training on mobility and balance in elderly

    International Nuclear Information System (INIS)

    Saddiqi, F.A.; Masood, T.

    2017-01-01

    To determine the effects of dynamic posturographic balance training versus conventional balance training in improving mobility and balance in elderly. Methodology: Forty subjects between 50 to 80 years of age were selected via non-probability convenience sampling technique, for this randomized controlled trial. Both females and males with no major co-morbid conditions and cognitive impairments were recruited and randomized via coin toss method into two equal groups: Dynamic Posturographic balance training (DPG) group and Conventional balance training (CBT) group. The DPG training was provided via Biodex Balance System (Static and Dynamic). Both groups received interventions 3 times (35 to 45min each day) a week for 8 weeks, after which terminal assessment was done. Data were collected on demographic profile, balance via berg balance score and mobility by using Timed Up and Go Test. Independent samples t test was used to check difference between CBT group and DPG Group and repeated measures Analysis of Variance (ANOVA) was used for within-group analysis. Results: Baseline analysis of Berg balance scale and timed up and go test between two groups showed no significant difference with (p 0.805 and 0.251, respectively). After 8 weeks of intervention, there was significant difference between the groups in both variables (p 0.019 and 0.001, respectively). Conclusion: Dynamic posturographic balance training was more effective in improving dynamic balance and mobility in elderly population in comparison to conventional balance training. (author)

  18. Interchangeability of the Wii Balance Board for Bipedal Balance Assessment.

    Science.gov (United States)

    Bonnechère, Bruno; Jansen, Bart; Omelina, Lubos; Rooze, Marcel; Van Sint Jan, Serge

    2015-08-27

    Since 2010, an increasing interest in more portable and flexible hardware for balance and posture assessment led to previously published studies determining whether or not the Wii Balance Board could be used to assess balance and posture, both scientifically and clinically. However, no previous studies aimed at comparing results from different Wii Balance Boards for clinical balance evaluation exist. The objective of this crossover study is to assess the interchangeability of the Wii Balance Board. A total of 6 subjects participated in the study and their balance was assessed using 4 different Wii Balance Boards. Trials were recorded simultaneously with Wii Balance Boards and with a laboratory force plate. Nine relevant clinical parameters were derived from center of pressure displacement data obtained from Wii Balance Board and force plate systems. Intraclass correlation coefficients (ICC), F tests, and Friedman tests were computed to assess the agreement between trials and to compare the Wii Balance Board and force plate results. Excellent correlations were found between the Wii Balance Board and force plate (mean ρ =.83). With the exception of 2 parameters, strong to excellent agreements were found for the 7 remaining parameters (ICC=.96). No significant differences were found between trials recorded with different Wii Balance Boards. Our results indicate that for most of the parameters analyzed, balance and posture assessed with one Wii Balance Board were statistically similar to results obtained from another. Furthermore, the good correlation between the Wii Balance Board and force plate results shows that Wii Balance Boards can be reliably used for scientific assessment using most of the parameters analyzed in this study. These results also suggest that the Wii Balance Board could be used in multicenter studies and therefore, would allow for the creation of larger populations for clinical studies. Ethical Committee of the Erasme Hospital (CCB B406201215142

  19. Wellbeing or welfare benefits

    DEFF Research Database (Denmark)

    Handlos, Line Neerup; Kristiansen, Maria; Nørredam, Marie Louise

    2016-01-01

    This debate article debunks the myth that migrants are driven primarily by the size of the welfare benefits in the host country, when they decide where to migrate to. We show that instead of welfare benefits, migrants are driven by a desire for safety, wellbeing, social networks and opportunities...

  20. Who Benefits from Religion?

    Science.gov (United States)

    Mochon, Daniel; Norton, Michael I.; Ariely, Dan

    2011-01-01

    Many studies have documented the benefits of religious involvement. Indeed, highly religious people tend to be healthier, live longer, and have higher levels of subjective well-being. While religious involvement offers clear benefits to many, in this paper we explore whether it may also be detrimental to some. Specifically, we examine in detail…

  1. Unemployment Benefit Exhaustion

    DEFF Research Database (Denmark)

    Filges, Trine; Pico Geerdsen, Lars; Knudsen, Anne-Sofie Due

    2015-01-01

    This systematic review studied the impact of exhaustion of unemployment benefits on the exit rate out of unemployment and into employment prior to benefit exhaustion or shortly thereafter. Method: We followed Campbell Collaboration guidelines to prepare this review, and ultimately located 12...

  2. Nanocosmetics: benefits and risks

    OpenAIRE

    Shokri, Javad

    2017-01-01

    Summary Various nanomaterials/nanoparticles (NPs) have been used for the development of cosmetic products - a field so-called nanocosmetic formulations. These advanced materials offer some benefits, while their utilization in the cosmetic formulations may be associated with some risks. The main aim of this editorial is to highlight the benefits and risks of the nanomaterials used in the cosmetic products.

  3. Radiation in medicine: Origins, risks and aspirations.

    OpenAIRE

    Donya, M; Radford, M; ElGuindy, A; Firmin, D; Yacoub, MH

    2014-01-01

    The use of radiation in medicine is now pervasive and routine. From their crude beginnings 100 years ago, diagnostic radiology, nuclear medicine and radiation therapy have all evolved into advanced techniques, and are regarded as essential tools across all branches and specialties of medicine. The inherent properties of ionizing radiation provide many benefits, but can also cause potential harm. Its use within medical practice thus involves an informed judgment regarding the risk/benefit rati...

  4. Solar energy and global heat balance of a city

    Energy Technology Data Exchange (ETDEWEB)

    Roulet, Claude-Alain [Ecole Polytechnique Federale, Lab. d' Energie Solaire et de Physique du Batiment, Lausanne (Switzerland)

    2001-07-01

    The global energy balance of a city involves numerous energy flows and is rather complex. It includes, among others, the absorbed solar radiation and the energy fuels on one hand, and the heat loss to the environment --- by radiation, convection and evaporation --- on the other hand. This balance generally results in a temperature in the town that is slightly higher than in the surrounding country. Using solar energy saves imported fuels on one hand, but increases the absorption of solar radiation on the other hand. Simple, steady state models are used to assess the change of heat released to the environment when replacing the use of classical fuels by solar powered plants, on both the global and city scale. The conclusion is that, in most cases, this will reduce the heat released to the environment. The exception is cooling, for which a good solar alternative does not exist today. (Author)

  5. Negative leave balances

    CERN Multimedia

    Human Resources Department

    2005-01-01

    Members of the personnel entitled to annual leave and, where appropriate, saved leave and/or compensatory leave are requested to take note of the new arrangements described below, which were recommended by the Standing Concertation Committee (SCC) at its meeting on 1Â September 2005 and subsequently approved by the Director-General. The changes do not apply to members of the personnel participating in the Progressive Retirement Programme (PRP) or the Part-time Work as a pre-retirement measure, for whom the specific provisions communicated at the time of joining will continue to apply. Â Negative balances in annual leave, saved leave and/or compensatory leave accounts at the end of the leave year (30th September) and on the date on which bonuses are credited to the saved leave account (31st December): Where members of the personnel have a leave account with a negative balance on 30Â September and/or 31Â December, leave will automatically be transferred from one account to another on the relevant dates i...

  6. Negative leave balances

    CERN Multimedia

    Human Resources Department

    2005-01-01

    Members of the personnel entitled to annual leave and, where appropriate, saved leave and/or compensatory leave are requested to take note of the new arrangements described below, which were recommended by the Standing Concertation Committee (SCC) at its meeting on 1 September 2005 and subsequently approved by the Director-General. The changes do not apply to members of the personnel participating in the Progressive Retirement Programme (PRP) or the Part-time Work as a pre-retirement measure, for whom the specific provisions communicated at the time of joining will continue to apply.  Negative balances in annual leave, saved leave and/or compensatory leave accounts at the end of the leave year (30th September) and on the date on which bonuses are credited to the saved leave account (31st December): Where members of the personnel have a leave account with a negative balance on 30 September and/or 31 December, leave will automatically be transferred from one account to another on the relevant dates in or...

  7. On output measurements via radiation pressure

    DEFF Research Database (Denmark)

    Leeman, S.; Healey, A.J.; Forsberg, F.

    1990-01-01

    It is shown, by simple physical argument, that measurements of intensity with a radiation pressure balance should not agree with those based on calorimetric techniques. The conclusion is ultimately a consequence of the circumstance that radiation pressure measurements relate to wave momentum, while...

  8. Balance ability and athletic performance.

    Science.gov (United States)

    Hrysomallis, Con

    2011-03-01

    The relationship between balance ability and sport injury risk has been established in many cases, but the relationship between balance ability and athletic performance is less clear. This review compares the balance ability of athletes from different sports, determines if there is a difference in balance ability of athletes at different levels of competition within the same sport, determines the relationship of balance ability with performance measures and examines the influence of balance training on sport performance or motor skills. Based on the available data from cross-sectional studies, gymnasts tended to have the best balance ability, followed by soccer players, swimmers, active control subjects and then basketball players. Surprisingly, no studies were found that compared the balance ability of rifle shooters with other athletes. There were some sports, such as rifle shooting, soccer and golf, where elite athletes were found to have superior balance ability compared with their less proficient counterparts, but this was not found to be the case for alpine skiing, surfing and judo. Balance ability was shown to be significantly related to rifle shooting accuracy, archery shooting accuracy, ice hockey maximum skating speed and simulated luge start speed, but not for baseball pitching accuracy or snowboarding ranking points. Prospective studies have shown that the addition of a balance training component to the activities of recreationally active subjects or physical education students has resulted in improvements in vertical jump, agility, shuttle run and downhill slalom skiing. A proposed mechanism for the enhancement in motor skills from balance training is an increase in the rate of force development. There are limited data on the influence of balance training on motor skills of elite athletes. When the effectiveness of balance training was compared with resistance training, it was found that resistance training produced superior performance results for

  9. Handbook of radiation effects

    International Nuclear Information System (INIS)

    Holmes-Siedle, A.; Adams, L.

    1993-01-01

    This handbook is intended to serve as a tool for designers of equipment and scientific instruments in cases where they are required to ensure the survival of the equipment in radiation environments. High-technology materials, especially semiconductors and optics, tend to degrade on exposure to radiation in many different ways. Intense high-energy radiation environments are found in nuclear reactors and accelerators, machines for radiation therapy, industrial sterilization, and space. Some engineers have to build equipment which will survive a nuclear explosion from a hostile source. Proper handling of a disaster with radioactive materials requires equipment which depends utterly on semiconductor microelectronics and imaging devices. Thus the technology of radiation-tolerant electronics is an instrument for good social spheres as diverse as disaster planning and the exploration of Mars. In order to design equipment for intense environments like those described above, then degradation from high-energy irradiation must be seen as a basic design parameter. The aim of this handbook is to assist the engineer or student in that thought; to make it possible to write intelligent specifications; to offer some understanding of the complex variety of effects which occur when high-technology components encounter high-energy radiation; and to go thoroughly into the balance of choices of how to alleviate the effects and hence achieve the design aims of the project. Separate abstracts were prepared for 15 chapters of this book

  10. Seasonal contrast in the surface energy balance of the Sahel

    Science.gov (United States)

    Miller, R. L.; Slingo, A.; Barnard, J. C.; Kassianov, E.

    2009-07-01

    Over much of the world, heating of the surface by sunlight is balanced predominately by evaporative cooling. However, at the Atmospheric Radiation Measurement (ARM) Mobile Facility (AMF) in Niamey, Niger, evaporation makes a significant contribution to the surface energy balance only at the height of the rainy season, when precipitation has replenished the reservoir of soil moisture. The AMF was placed at Niamey from late 2005 to early 2007 to provide measurements of surface fluxes in coordination with geostationary satellite retrievals of radiative fluxes at the top of the atmosphere, as part of the RADAGAST experiment to calculate atmospheric radiative divergence. We use observations at the mobile facility to investigate how the surface adjusts to radiative forcing throughout the year. The surface response to solar heating varies with changes in atmospheric water vapor associated with the seasonal reversal of the West African monsoon, which modulates the greenhouse effect and the ability of the surface to radiate thermal energy directly to space. During the dry season, sunlight is balanced mainly by longwave radiation and the turbulent flux of sensible heat. The ability of longwave radiation to cool the surface drops after the onset of southwesterly surface winds at Niamey, when moist, oceanic air flows onshore, increasing local column moisture and atmospheric opacity. Following the onset of southwesterly flow, evaporation remains limited by the supply of moisture from precipitation. By the height of the rainy season, however, sufficient precipitation has accumulated that evaporation is controlled by incident sunlight, and radiative forcing of the surface is balanced comparably by the latent, sensible, and longwave fluxes. Evaporation increases with the leaf area index, suggesting that plants are a significant source of atmospheric moisture and may tap moisture stored beneath the surface that accumulated during a previous rainy season. Surface radiative forcing

  11. Exploring antecedents of experimentation and implementation of the balanced scorecard

    NARCIS (Netherlands)

    Braam, G.J.M.; Nijssen, E.J.

    2011-01-01

    Adoption of management innovations like the balanced scorecard is generally a complex process. Many subdecisions are involved and customization is often required before firms can enjoy the benefits of these innovations. Consequently, firms tend to experiment before finally implementing such complex

  12. Operational Management of Intraday and Balancing Markets - a survey

    DEFF Research Database (Denmark)

    Andersen, Jeanne; K. Detlefsen, Nina

    changes and challenges, which may be better addressed with closer collaboration. In order to evaluate the benefits of cross-border balancing, it is essential to have an understanding of the mechanisms and operations of the European markets and how they interact. Therefore, this paper aims at describing...

  13. Strategy Revitalization in Academe: A Balanced Scorecard Approach

    Science.gov (United States)

    McDevitt, Roselie; Giapponi, Catherine; Solomon, Norman

    2008-01-01

    Purpose: The purpose of this paper is to present a unique version of the balanced scorecard developed and applied by the faculty of a university division. Design/methodology/approach: The paper uses a case study approach and uses the experiences of the faculty of a business school to describe the process and benefits of developing a custom…

  14. Development of a vital-sign/fluid-balance flow sheet.

    Science.gov (United States)

    Ozuna, L A; Adkins, A T

    1993-01-01

    An improved flow sheet for recording vital signs and fluid balance on a medical oncology unit was developed and tested using quality-assurance techniques. The new form, which replaced three separate forms, measurably improved documentation on all quality-assurance monitors tested. Additional benefits include cost-savings and decreased time expenditures by nursing staff.

  15. Sustaining a world in balance.

    Science.gov (United States)

    1992-04-01

    The world balance of population and resources is the internationally accepted goal for the 20th century. There is agreement that the requirements are elimination of absolute poverty, the legitimate satisfaction of the majority population, reduction in the environmental cost of development, fairer distribution of the benefits of development, slower population growth, and more balanced distribution within and between countries. A profile is given for 15 development and population measures for the Philippines. In the Philippines over 50% of the population lives in poverty, and the numbers are increasing. Unemployment is high at 10.6% in 1991, and underemployment is estimated to be 31.6%. Limited employment opportunities are push factors for international labor migration, which has swelled to over 600,000 workers. The Philippines is losing forest at the rate of about 119,000 hectares per year, which would result in a total loss of forests in 12 years. The loss of biodiversity is apparent. Marine resources are being depleted, and average farm size per rural person is 0.38 hectares. The average family of 6 persons must produce food on only 2.28 hectares. The annual population growth rate is 2.3%, and the rate of food production is only 1%. Metro Manila is now the 18th largest urban area in the world. Air pollution is very high, and the water supply is polluted with salt. 14% of children under 6 years old are severely underweight. Iron deficiency anemia affects 60% of children 1-6 years old and 40% of children 7-12 years old. 3.5 million children are working, and 20,000 are child prostitutes. 85,000 street children live in 17 cities. Maternal mortality is estimated at 1600 women each year, and 24% of deaths in 78 hospitals were due to induced abortion. About 2.7 million women have unmet need for family planning, and 1.8 million desire family planning but are not using any method.

  16. The philosophy behind the federal radiation council guides

    International Nuclear Information System (INIS)

    Tompkins, P.C.

    1969-01-01

    The basic philosophy of the FRC in making recommendations for the control of radioactivity associated with normal peacetime operations is given in FRC report. Radiation Protection Guides for application to activities such as Plowshare would be derived on the basis of this philosophy. Considerations involve a balance of benefit versus risk for each Plowshare activity that is proposed for industrial application using potential exposures small in comparison to the basic guide of 0.17 rem per year as the primary reference condition. Alternate approaches to achieving an appropriate balance have been suggested. These include allocation of a fraction of the 0.17 rem per capita per year to each relevant activity; setting a universally applicable MPC for each nuclide of interest, and the concept of the dose commitment. Data to show the benefit in terms of the national need for the resource in question (e.g., gas production) and the risk as indicated by the amount of residual radioactivity is a prerequisite to setting guidance for using Plowshare techniques in conjunction with consumer products available to the general public. (author)

  17. Quantifying the costs and benefits of energy

    International Nuclear Information System (INIS)

    Lindell, B.

    1975-06-01

    A number of principles which have been developed for cost-benefit assessments in the radiation field are applied to the more general cost-benefit assessment of energy production. Sources of energy may be assessed in relation to a reference practice. If this is done for one and the same electricity production, the main objective is to assess detriments in comparable terms. Detriment rates may be integrated in space and time and might also be expressed in equivalent monetary units. Although there are several practical limitations to any theoretical treatment of the problem, the basic principles may form a useful background to more realistic although more complicated approaches to the task. (author)

  18. Cost/benefit analyses of environmental impact

    International Nuclear Information System (INIS)

    Goldman, M.I.

    1974-01-01

    Various aspects of cost-benefit analyses are considered. Some topics discussed are: regulations of the National Environmental Policy Act (NEPA); statement of AEC policy and procedures for implementation of NEPA; Calvert Cliffs decision; AEC Regulatory Guide; application of risk-benefit analysis to nuclear power; application of the as low as practicable (ALAP) rule to radiation discharges; thermal discharge restrictions proposed by EPA under the 1972 Amendment to the Water Pollution Control Act; estimates of somatic and genetic insult per unit population exposure; occupational exposure; EPA Point Source Guidelines for Discharges from Steam Electric Power Plants; and costs of closed-cycle cooling using cooling towers. (U.S.)

  19. Calculation of benefit reserves based on true m-thly benefit premiums

    Science.gov (United States)

    Riaman; Susanti, Dwi; Supriatna, Agus; Nurani Ruchjana, Budi

    2017-10-01

    Life insurance is a form of insurance that provides risk mitigation in life or death of a human. One of its advantages is measured life insurance. Insurance companies ought to give a sum of money as reserves to the customers. The benefit reserves are an alternative calculation which involves net and cost premiums. An insured may pay a series of benefit premiums to an insurer equivalent, at the date of policy issue, to the sum of to be paid on the death of the insured, or on survival of the insured to the maturity date. A balancing item is required and this item is a liability for one of the parties and the other is an asset. The balancing item, in loan, is the outstanding principle, an asset for the lender and the liability for the borrower. In this paper we examined the benefit reserves formulas corresponding to the formulas for true m-thly benefit premiums by the prospective method. This method specifies that, the reserves at the end of the first year are zero. Several principles can be used for the determined of benefit premiums, an equivalence relation is established in our discussion.

  20. Radiation protection

    CERN Multimedia

    CERN. Geneva

    2001-01-01

    This will be a simple explanation of the reasons why CERN has to be careful about radiation protections issues, a practical guide on how to recognize radiation dangers, the monitoring systems that make sure radiation levels are well tolerable norms, and a quick summary of what radiation levels mean in terms of personal risk.

  1. Electronics Environmental Benefits Calculator

    Science.gov (United States)

    The Electronics Environmental Benefits Calculator (EEBC) was developed to assist organizations in estimating the environmental benefits of greening their purchase, use and disposal of electronics.The EEBC estimates the environmental and economic benefits of: Purchasing Electronic Product Environmental Assessment Tool (EPEAT)-registered products; Enabling power management features on computers and monitors above default percentages; Extending the life of equipment beyond baseline values; Reusing computers, monitors and cell phones; and Recycling computers, monitors, cell phones and loads of mixed electronic products.The EEBC may be downloaded as a Microsoft Excel spreadsheet.See https://www.federalelectronicschallenge.net/resources/bencalc.htm for more details.

  2. Financing gas plants using off balance sheet structures

    International Nuclear Information System (INIS)

    Best, R.J.; Malcolm, V.

    1999-01-01

    A means by which to finance oil and gas facilities using off balance sheet structures was presented. Off balance sheet facility financing means the sale by an oil and gas producer of a processing and/or transportation facility to a financial intermediary, who under a Management Agreement, appoints the producer as the operator of the facility. The financial intermediary charges a fixed processing fee to the producer and all the benefits and upside of ownership are retained by the producer. This paper deals specifically with a flexible off balance sheet facility financing structure that can be used to make effective use of discretionary capital which is committed to gas processing and to the construction of new gas processing facilities. Off balance sheet financing is an attractive alternative method of ownership that frees up capital that is locked into the facilities while allowing the producer to retain strategic control of the processing facility

  3. Balancing Family and Career

    Science.gov (United States)

    Andam, Aba Bentil; Dawson, Silvina Ponce; Horton, K. Renee; Sandow, Barbara

    2005-10-01

    In essentially all countries, responsibilities for child care, cooking, cleaning, and other homemaking tasks fall predominantly on the wife and mother. In addition, the childbearing years come during the period when a physicist must study hard, work long hours on research, and take temporary positions, often abroad. Thus, balancing family and career has long been one of the major barriers to women's participation in science and engineering fields, including physics. While many young women believe that they must choose between having children and having a science career, the fact is that the majority of women physicists in both developing and developed countries have successfully done both. This paper summarizes some ideas and recommendations raised in discussions, especially focused on easing the challenges of having children while in temporary jobs, returning to physics after a career break, the need for "family-friendly" working conditions, and the dual-career problem facing couples where both are scientists.

  4. Balancing Trust and Control

    DEFF Research Database (Denmark)

    Jagd, Søren

    2010-01-01

    The purpose of this paper is to show that conceptualizing trust and control as interactively related processes, as opposed to more static conceptualizations of the two concepts and the relations between them, adds importantly towards understanding the challenges involved in balancing of trust...... and control in organizations. The paper examines recent literature on the conceptualization of the relation between trust and control in and between organizations. The literature review shows that trust and control has been conceptualized as either substituting or complementing each other. Further......, it is found that the complementary/substitution debate calls for an explicit conceptualization of the relation between trust and control as an interactive process, in contrast to earlier conceptualizations of trust and control as two relatively static and isolated concepts. While the static perspective...

  5. [Balanced scorecard in health].

    Science.gov (United States)

    Leyton-Pavez, Carolina Elena; Huerta-Riveros, Patricia Carolina; Paúl-Espinoza, Iván Renato

    2015-01-01

    To evaluate the installation of strategies in the higher complexity hospitals (HMC, in Spanish) of public health in Chile starting from the results of the Balanced Scorecard (BSC), during the years 2011-2012. The implementation of the BSC is described, the strategies and indicators identified, and the results of the 57 HMC compared and analyzed. Starting from the comparison of the results it is discovered that the BSC allows to evaluate the installation of the strategies. Differences are identified in the installation of the strategies by geographical area, with North presenting a higher score (20.21), followed by Center (10.41) and South (19.50), which can be explained by the size and complexity of this establishments, variables that should be incorporated in the evaluation of the results of the BSC.

  6. Work-life balance

    Energy Technology Data Exchange (ETDEWEB)

    Roche, Pat

    2011-03-15

    Gay Renouf has opted for a work/life balance; with a chemistry degree she joined the Saskatchewan Research Council out of graduate school in 1986. She first worked on understanding surfactants in emulsions and then dealt more with petroleum engineering issues like pipeline specifications. She is looking at waterfloods in heavy and medium gravity pools and has discovered factors helping to produce heavy oil waterfloods. But all Renouf's life is not devoted to her work: she has been working part-time, spending her free time being a parent, training for marathons and being a running coach. Renouf believes that her passion for running is consistent with her work as a scientist.

  7. Balance Toward Language Mastery

    Directory of Open Access Journals (Sweden)

    Virginia R. Heslinga

    2017-01-01

    Full Text Available Problems in attaining language mastery with students from diverse language backgrounds and levels of ability confront educators around the world. Experiments, research, and experience see positive effects of adding sign language in communication methods to pre-school and K-12 education. Augmentative, alternative, interactive, accommodating, and enriching strategies using sign language aid learners in balancing the skills needed to mastery of one language or multiple languages. Theories of learning that embrace play, drama, motion, repetition, socializing, and self-efficacy connect to the options for using sign language with learners in inclusive and mainstream classes. The methodical use of sign language by this researcher-educator over two and a half decades showed signing does build thinking skills, add enjoyment, stimulate communication, expand comprehension, increase vocabulary acquisition, encourage collaboration, and helps build appreciation for cultural diversity.

  8. Space Flight Ionizing Radiation Environments

    Science.gov (United States)

    Koontz, Steve

    2017-01-01

    The space-flight ionizing radiation (IR) environment is dominated by very high-kinetic energy-charged particles with relatively smaller contributions from X-rays and gamma rays. The Earth's surface IR environment is not dominated by the natural radioisotope decay processes. Dr. Steven Koontz's lecture will provide a solid foundation in the basic engineering physics of space radiation environments, beginning with the space radiation environment on the International Space Station and moving outward through the Van Allen belts to cislunar space. The benefits and limitations of radiation shielding materials will also be summarized.

  9. Ethical problems in radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Shrader-Frechette, K.; Persson, Lars

    2001-05-01

    In this report the authors survey existing international radiation-protection recommendations and standards of the ICRP, the IAEA, and the ILO. After outlining previous work on the ethics of radiation protection, professional ethics, and the ethics of human radiation experiments, the authors review ethical thinking on seven key issues related to radiation protection and ethics. They formulate each of these seven issues in terms of alternative ethical stances: (1) equity versus efficiency, (2) health versus economics, (3) individual rights versus societal benefits, (4) due process versus necessary sacrifice, (5) uniform versus double standards, (6) stake holder consent versus management decisions, and (7) environmental stewardship versus anthropocentric standards.

  10. Ethical problems in radiation protection

    International Nuclear Information System (INIS)

    Shrader-Frechette, K.; Persson, Lars

    2001-05-01

    In this report the authors survey existing international radiation-protection recommendations and standards of the ICRP, the IAEA, and the ILO. After outlining previous work on the ethics of radiation protection, professional ethics, and the ethics of human radiation experiments, the authors review ethical thinking on seven key issues related to radiation protection and ethics. They formulate each of these seven issues in terms of alternative ethical stances: (1) equity versus efficiency, (2) health versus economics, (3) individual rights versus societal benefits, (4) due process versus necessary sacrifice, (5) uniform versus double standards, (6) stake holder consent versus management decisions, and (7) environmental stewardship versus anthropocentric standards

  11. Work-life balance: Does age matter?

    Science.gov (United States)

    Richert-Kaźmierska, Anita; Stankiewicz, Katarzyna

    2016-11-22

    Work-life balance is a priority of EU policies but at the same time demographic change affects the labour market. Employers have to deal with the ageing of their employees and adjust human resource management to maintain their competitiveness. The purpose of the article is to answer research questions: whether the age of workers determines their assessment of the work-life balance, and whether there is a relationship between the worker's age and their assessment of the activities undertaken by their employer to provide them with work-life balance. The article is based on the results of surveys conducted among 500 employees of the SME sector from Finland, Lithuania and Sweden. The results identified a statistically significant difference: employees representing older age groups are more likely to indicate the maintenance of WLB; older workers more frequently do not agree that all workers have equal opportunities to benefit from flexible solutions aimed at ensuring the maintenance of WLB. The results can be the inspiration for the decisions and actions of employers in the field of personnel management and for creating workplace conditions encouraging senior workers to continue working, even upon becoming entitled to old-age pension.

  12. Application of radiation nowadays

    International Nuclear Information System (INIS)

    Habibah Adnan

    2009-01-01

    Despite of scientist know about radiation since 1890, but they have successfully developed many of application to help human life. Now, we can see that radiation was applied in medical, academic, industrial, and generating electricity. Besides that, radiations also have other applications that can help in agriculture activities, archaeology, legislation, geology, space exploration and many more. In hospital, doctor use nuclear medicine to trace, monitor and save almost thousands of people every year. According to research, 7 out of 10 American citizens had already use this services at least once in their life. Universities, college, secondary school, research center also use nuclear material in their laboratory. For example, through research, radiation can help in plants study, agriculture technique, soils study and others. Industrial sector are one sector that applied radiation widely. For example, radiation can kill almost 80 % bacteria or dangerous microorganism in food or export products. Nowadays, radiation cannot be curtailed although it can give more benefit more than risk. It depends on how we manage it.

  13. Beneficial uses of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Fox, M.R.

    1991-10-01

    An overall decline in technical literacy within the American public has come at a time when technological advances are accelerating in the United States and around the world. This had led to a large communication gulf between the general public and the technologists. Nowhere is this more evident then with the topic of radiation. Regrettably, too few people know about sources of radiation, the pervasiveness, amounts, and variabilities, and do not have a true understanding of the environment in which we live. Nor do many people know that radiation has been used in beneficial ways for decades around the world. While the general public does not know of the scientific applications to which radiation has been deployed, it nevertheless had benefited tremendously from these efforts. Thanks to the well know properties of radiation, scientific ingenuity has found many uses of radiation in chemical and agricultural research, biomedical research, in the diagnoses and treatment of hundreds of types of diseases, in industrial applications, food irradiation, and many others. This paper provides a sample of the types of uses to which radiation has been used to help advance the betterment of humankind.

  14. Beneficial uses of radiation

    International Nuclear Information System (INIS)

    Fox, M.R.

    1991-10-01

    An overall decline in technical literacy within the American public has come at a time when technological advances are accelerating in the United States and around the world. This had led to a large communication gulf between the general public and the technologists. Nowhere is this more evident then with the topic of radiation. Regrettably, too few people know about sources of radiation, the pervasiveness, amounts, and variabilities, and do not have a true understanding of the environment in which we live. Nor do many people know that radiation has been used in beneficial ways for decades around the world. While the general public does not know of the scientific applications to which radiation has been deployed, it nevertheless had benefited tremendously from these efforts. Thanks to the well know properties of radiation, scientific ingenuity has found many uses of radiation in chemical and agricultural research, biomedical research, in the diagnoses and treatment of hundreds of types of diseases, in industrial applications, food irradiation, and many others. This paper provides a sample of the types of uses to which radiation has been used to help advance the betterment of humankind

  15. Benefits of Java

    Science.gov (United States)

    ... health benefits as well. Drinking moderate amounts of coffee (including decaf) has been linked to lower risk of cardiovascular disease, Type 2 diabetes, Parkinson's disease and some cancers. And those antioxidants? Although ...

  16. Contraceptives with novel benefits.

    Science.gov (United States)

    Su, Ying; Lian, Qing-Quan; Ge, Ren-Shan

    2012-01-01

    Progesterone receptor (PR) agonists (progestins) and antagonists are developed for female contraceptives. However, non-contraceptive applications of newer progestins and PR modulators are being given more attention. The newer PR agonists including drospirenone, nomegestrol, trimegestone, dienogest and nestorone are being evaluated as contraceptives with health benefits because of their unique pharmacological properties. The selective PR modulators (SPRM; PR antagonists with PR agonistic properties) are under development not only for emergency contraception but also for other health benefits such as the treatment of endometritis and leiomyoma. After searching the literature from PubMed, clinicaltrials.gov and patent database, this review focuses on the effects and mechanisms of these progestins, and SPRMs as contraceptives with other health benefits. PR agonists and antagonists that have novel properties may generate better contraceptive effects with other health benefits.

  17. Benefits of being biased!

    Indian Academy of Sciences (India)

    Administrator

    Keywords. codon bias; alcohol dehydrogenase; Darwinian fitness; Drosophila melanogaster. RESEARCH COMMENTARY. Benefits of being biased! SUTIRTH DEY*. Evolutionary Biology Laboratory, Evolutionary & Organismal Biology Unit,. Jawaharlal Nehru Centre for Advanced Scientific Research,. Jakkur P.O. Box 6436 ...

  18. The benefits of prone SPECT myocardial perfusion imaging in reducing both artifact defects and patient radiation exposure; Beneficio da aquisicao de imagem na posicao Prona em perfusao miocardica com SPECT para reducao de artefatos e exposicao do paciente a radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Stathaki, Maria; Koukouraki, Sophia; Papadaki, Emmanouela; Tsaroucha, Angeliki; Karkavitsas, Nikolaos, E-mail: mariast_cha@yahoo.gr [Department of Nuclear Medicine, University Hospital of Heraklion, Crete (Greece)

    2015-10-15

    Background: Prone imaging has been demonstrated to minimize diaphragmatic and breast tissue attenuation. Objectives: To determine the role of prone imaging on the reduction of unnecessary rest perfusion studies and coronary angiographies performed, thus decreasing investigation time and radiation exposure. Methods: We examined 139 patients, 120 with an inferior wall and 19 with an anterior wall perfusion defect that might represented attenuation artifact. Post-stress images were acquired in both the supine and prone position. Coronary angiography was used as the 'gold standard' for evaluating coronary artery patency. The study was terminated and rest imaging was obviated in the presence of complete improvement of the defect in the prone position. Quantitative interpretation was performed. Results were compared with clinical data and coronary angiographic findings. Results: Prone acquisition correctly revealed defect improvement in 89 patients (89/120) with inferior wall and 12 patients (12/19) with anterior wall attenuation artifact. Quantitative analysis demonstrated statistically significant difference in the mean summed stress scores (SSS) of supine and mean SSS of prone studies in patients with disappearing inferior wall defect in the prone position and patent right coronary artery (true negative results). The mean difference between SSS in supine and in prone position was higher with disappearing than with remaining defects. Conclusion: Technetium-99m (Tc-99m) tetrofosmin myocardial perfusion imaging with the patient in the prone position overcomes soft tissue attenuation; moreover it provides an inexpensive, accurate approach to limit the number of unnecessary rest perfusion studies and coronary angiographies performed. (author)

  19. Individual isotoxic radiation dose escalation based on V20 and advanced technologies benefits unresectable stage III non-small cell lung cancer patients treated with concurrent chemoradiotherapy: long term follow-up.

    Science.gov (United States)

    Liu, Ming; Wang, Zhongtang; Zhou, Tao; Zhou, Antang; Zhao, Qian; Li, Hongsheng; Sun, Hongfu; Huang, Wei; Li, BaoSheng

    2017-08-01

    Under the assumption that the highest therapeutic ratio could be achieved by increasing the total tumor dose (TTD) to the limits of normal tissues, the phase I trial was conducted in patients with unresectable stage III non-small cell lung cancer treated with concurrent chemoradiotherapy, to determine the feasibility and effects of individual isotoxic radiation dose escalation based on bilateral lung V20 and advanced technologies. Consecutive eligible patients were assigned to cohorts of eight. V20 of each cohort was increased from 27% to 30%, 33%, 35%, 37%, and so on. The criterion for cessation of dose escalation was defined as ≥ 2 patients in each cohort experienced dose limiting toxicity. Isotoxic dose escalation was based on V20, functional imaging was used to improve the accuracy of radiotherapy. To test the power of escalation dose, patients with TTD over 66 Gy were assigned to the higher dose group (HD), while the others to the standard dose one (SD). In result, the recommended value of V20 was 35%. For all patients, follow-up ranged from 1 to 112 months, median overall and progression free survivals were 25.0 and 13.0 months, respectively. The 1-, 3-, 5- and 8-year overall survival (OS) rates were 72.5%, 22.5%, 17.5%, and 10.0%, respectively. Especially, the OS and local recurrence-free survival of patients in HD group were significantly longer than those in SD one ( P =0.035, P=0.007, respectively) without increasing severe toxicity. Thus, individual isotoxic dose escalation based on V20 with advanced technologies was feasible and effective.

  20. Benefits for handicapped children

    CERN Multimedia

    2003-01-01

    The introduction of long-term care benefits within the CERN Health Insurance Scheme requires the coordination of the benefits foreseen for handicapped children. Measures were adopted by the Management following the recommendation made by the Standing Concertation Committee on 26 March 2003. A document clarifying these measures is available on the Web at the following address: http://humanresources.web.cern.ch/humanresources/external/soc/Social_affairs/social_affairs.asp Social Affairs Service 74201

  1. Work-Life Balance Practices Among Irish Hotel Employees:Implications for HRM

    OpenAIRE

    Farrell, Kathleen

    2015-01-01

    The aim of this paper is to examine work-life balance in the Irish hotel sector from an employee perspective with implications for HRM. 246 questionnaires from employees were returned which was a 22% response rate. Company benefits were not associated with numerical flexibility, but company benefits were associated with functional flexibility and work-life balance supports. This would suggest an integrated approach to human resource management (HRM), whereby some companies engage in a contemp...

  2. Radar channel balancing with commutation

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2014-02-01

    When multiple channels are employed in a pulse-Doppler radar, achieving and maintaining balance between the channels is problematic. In some circumstances the channels may be commutated to achieve adequate balance. Commutation is the switching, trading, toggling, or multiplexing of the channels between signal paths. Commutation allows modulating the imbalance energy away from the balanced energy in Doppler, where it can be mitigated with filtering.

  3. Effect of ultraviolet-B radiation on biochemical and antioxidant ...

    African Journals Online (AJOL)

    International Journal of Engineering, Science and Technology ... The results suggest that Indigofera tinctoria is resistant to UV-B radiation damage and the possible negative effect of additional UV-B radiation on the growth of seedling may have been effectively balanced by the UV-B radiation stress through increase in ...

  4. Radiative Transfer Reconsidered as a Quantum Kinetic Theory ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... We revisit the radiative transfer theory from first principles approach, inspired from quantum kinetic theory. The radiation field is described within the second quantization formalism. A master equation for the radiation density operator is derived and transformed into a balance relation in the phase space, ...

  5. When Do States Balance Power?

    DEFF Research Database (Denmark)

    Hariri, Jacob Gerner; Wivel, Anders

    2010-01-01

    This paper explores the logic of balancing in structural realist theory. Arguably, the durability of the unipolar moment is a challenge to the logic of balancing. The paper uses the tools of microeconomics to build a mathematical model of structural realism. The simple model reiterates...... the structural realist prediction that the weaker states should balance the unipole. Under a slight model extension, it is shown that efforts to balance in separate capabilities always tends to offset each other. Under this extension, the durability of the unipolar moment is in fact consistent...

  6. Kin Selection - Mutation Balance

    DEFF Research Database (Denmark)

    Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

    2011-01-01

    Abstract Social conflict, in the form of intraspecific selfish "cheating" has been observed in a number of natural systems. However, a formal, evolutionary genetic theory of social cheating that provides an explanatory, predictive framework for these observations is lacking. Here we derive the kin...... control, such as policing. We find that increasing relatedness reduces the cheater load more efficiently than does policing the costs and benefits of cooperation. Our results provide new insight into the effects of genetic systems, mating systems, ecology, and patterns of sex-limited expression on social...

  7. Radiation, people and the environment

    International Nuclear Information System (INIS)

    Ford, J.

    2004-02-01

    Radiation is a fact of life. We live in a world in which radiation is naturally present everywhere. Light and heat from nuclear reactions in the Sun are essential to our existence. Radioactive materials occur naturally throughout the environment, and our bodies contain radioactive materials such as carbon-14, potassium-40 and polonium-210 quite naturally. All life on Earth has evolved in the presence of this radiation. Since the discovery of X rays and radioactivity more than 100 years ago, we have found ways of producing radiation and radioactive materials artificially. The first use of X rays was in medical diagnosis, within six months of their discovery in 1895. So a benefit from the use of radiation was established very early on, but equally some of the potential dangers of radiation became apparent in the doctors and surgeons who unwittingly overexposed themselves to X rays in the early 1900s. Since then, many different applications of radiation and radioactive materials have been developed. We can classify radiation according to the effects it produces on matter, into ionizing and non-ionizing radiation. Ionizing radiation includes cosmic rays, X rays and the radiation from radioactive materials. Non-ionizing radiation includes ultraviolet light, radiant heat, radio waves and microwaves. This book deals with ionizing radiation, a term, which for simplicity, is often shortened to just radiation. It has been prepared by the International Atomic Energy Agency (IAEA) in co-operation with the National Radiological Protection Board (United Kingdom) as a broad overview of the subject of ionizing radiation, its effects and uses, as well as the measures in place to use it safely. As the United Nations agency for nuclear science and its peaceful applications, the IAEA offers a broad spectrum of expertise and programmes to foster the safe use of radiation internationally

  8. Radiation protection cabin for catheter-directed liver interventions: operator dose assessment

    International Nuclear Information System (INIS)

    Maleux, Geert; Bosmans, Hilde; Bergans, Niki; Bogaerts, Ria

    2016-01-01

    The number and complexity of interventional radiological procedures and in particular catheter-directed liver interventions have increased substantially. The current study investigates the reduction of personal doses when using a dedicated radiation protection cabin (RPC) for these procedures. Operator and assistant doses were assessed for 3 series of 20 chemo-infusion/chemoembolisation interventions, including an equal number of procedures with and without RPC. Whole body doses, finger doses and doses at the level of knees and eyes were evaluated with different types of TLD-100 Harshaw dosemeters. Dosemeters were also attached on the three walls of the RPC. The operator doses were significantly reduced by the RPC, but also without RPC, the doses appear to be limited as a result of thorough optimisation with existing radiation protection tools. The added value of the RPC should thus be determined by the outcome of balancing dose reduction and other aspects such as ergonomic benefits. (authors)

  9. The benefits from environmental remediation

    International Nuclear Information System (INIS)

    Falck, W.E.

    2002-01-01

    Environmental remediation projects inevitably take place against a backdrop of overall social goals and values. These goals can include, for example, full employment, preservation of the cultural, economic and archaeological resources, traditional patterns of land use, spiritual values, quality of life factors, biological diversity, environmental and socio-economic sustainability, protection of public health. Different countries will have different priorities, linked to the overall set of societal goals and the availability of resources, including funding, man-power and skills. These issues are embedded within both a national and local socio-cultural context, and will shape the way in which the remediation process is structured in any one country. The context will shape both the overall objectives of a remediation activity within the framework of competing societal goals, as well as generate constraints on the decision making process. Hence, the overall benefit of a remediation project is determined by its overall efficiency and effectiveness within the given legal, institutional, and governance framework, under the prevailing socio-economic boundary conditions, and balancing technology performance and risk reduction with fixed or limited budgetary resources, and is not simply the result of the technical remediation operation itself. (author)

  10. Benefit-cost analysis of OHER research

    International Nuclear Information System (INIS)

    Nesse, R.J.

    1988-01-01

    This research was undertaken to estimate societal benefits and costs of selected past research performed for OHER. Three case studies of representative OHER and DOE research were performed. One of these, the acid rain case study, included research conducted in another office in DOE. The other two cases were the OHER marine research program and the OHER project that developed high-purity germanium used in radiation detectors. The acid rain case study looked at research benefits and costs of furnace sorbent injection and duct injection, technologies that might reduce acid deposition precursors. Both appeared to show benefits in excess of costs. They examined in detail one of the marine research program's accomplishments, the increase in environmental information used by the Outer Continental Shelf leasing program to manage bidding for off-shore oil drilling. The results of an econometric model showed that, environmentally, marine research supported by OHER is unequivocally linked to government and industry leasing decisions. Finally, the germanium case study indicated that benefits of germanium radiation detectors were significant

  11. Interim balance: Ecology

    International Nuclear Information System (INIS)

    Kogon, E.; Jungk, R.

    1981-01-01

    Subjects: The ecology problem - world wide. Sectoral balances: The examples of energy, transportation, chemistry, agriculture and food industry, water supply. Destruction of nature and human discord. Conservatives in our political parties and their views on environmental protection. Alliance between reds and 'greens', integration between reds and greens. The Rhine initiative. Lead respects no borders, experiences of citizens' action groups in Lothringia and the Saar district. International airport Munich-II/comments by a protestant. 'Give priority to life'/A hearing on environmental protection. 4:96 - 'greens' in the Bremen Senate. Policy in a hard-hearing world/psychology of citizens' action groups. Critical ecological research and scientific establishment. Full productivity and ecology. The deluge to follow/Hints on how to build an ark. Symbiosis is more than coexistence/Ecologists' social theory. Throwing in two hundred elementary particles/on the way to an ecological concept of science. Scientific journals. Alternative literature. Teaching model for a teaching subject 'ecology'. (orig.) [de

  12. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  13. Balancing "we" and "me".

    Science.gov (United States)

    Congdon, Christine; Flynn, Donna; Redman, Melanie

    2014-10-01

    The open office is the dominant form of workspace design for good reason: It fosters collaboration, promotes learning, and nurtures strong culture. But what most companies fail to realize is that collaboration has a natural rhythm that requires both interaction and private contemplation. Companies have been trying for decades to find the balance between public and private workspace that best supports collaboration. In 1980 52% of U.S. employees lacked workspaces where they could concentrate without distraction. In response, high-walled cubicles took over the corporate landscape. By the late 1990s, the tide had turned, and only 23% of employees wanted more privacy, and 50% wanted more access to other people. Ever since, firms have been beefing up spaces that support collaboration and shrinking areas for individual work. But the pendulum seems to have swung too far: Once again, people feel a pressing need for privacy, not only to do heads-down work but to cope with the intensity of work today. To address these needs, according to the authors, we have to rethink our assumptions about privacy. Traditionally defined in physical terms, privacy is now about the individual's ability to control information and stimulation. In this article, the authors examine workspace design through the new lens of privacy and offer insights on how to foster teamwork and solitude.

  14. The right balance

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Over the course of her career as a physicist, Felicitas Pauss, currently responsible for CERN's External Relations, has often been the sole woman in an environment dominated by men. While she freely admits that being a woman physicist can have as many advantages as disadvantages, she thinks the best strategy is to maintain the right balance.   From a very early age, Felicitas Pauss always wanted to be involved in projects that interested and fascinated her. That's how she came to study physics. When she was a first-year university student in Austria in 1970, it was still fairly uncommon for women to go into physics research. "I grew up in Salzburg with a background in music. At that time, it was certainly considered more ‘normal’ for a woman to study music than to do research in physics. But already in high school I was interested in physics and technical instruments and wanted to know how things work and what they are made of”. At the beginning of her care...

  15. Paul Collier : Balancing beams

    CERN Multimedia

    2009-01-01

    As former head of AB Operations, Paul Collier and his group were in the ‘cockpit’ for the LHC’s maiden voyage - piloting the first beam around the ring. But now, as Head of the Beams Department, he will need his feet firmly on the ground in order to balance all the beam activities at CERN. "As Department Head, I’ll have less direct contact with the machines," Collier says with a hint of regret. "I’ll still obviously be very involved, but they won’t actually let me loose in front of the keyboard anymore!" As the new Head of the BE Department, Collier will be in charge of nearly 400 people, and will oversee all the beam activities, including the preparations for the longest period of beam operation in the history of CERN. In the new organization, the BE, TE and EN Departments have been grouped together in the Accelerator and Technology Sector. "‘Partnership’ is a key word for the three departments," says Collier. "The n...

  16. Present status of radiation education in Bangladesh

    International Nuclear Information System (INIS)

    Ullah, Sana

    1999-01-01

    Radioisotopes and Radiation are being widely used in the fields of agriculture, medicine, industry for the benefit of people throughout the world. At the same time the use of radiation sources can do harm to man and environment. In order to ensure the satiety against radiation hazards and safe use of radiation, proper education, training, knowledge and awareness are essential. Like other achieve economic development through application f count rues Bangladesh is flying to in agriculture, food, industry, power; health or medi of isotopes and radiation technology cine. Basic education about radiation is incorporated in the school curriculum. Courses on radiation are also given in college and university education. Research organizations, universities carry out research and development works on different disciplines using radiation and radioisotopes. Seminars, workshops, conferences, takings on isotopes and radiation are also being organized. In 1993 Government of Bangladesh passed the Nuclear Satiety and Radiation Control Act 1993 for see use of radiation. The present paper win cover the radiation education, research and development works on radiation, applications of radiation in agriculture, medicine and industry, personal safety and radiation protection against radiation hazard and rules and regulations of the nuclear safety and radiation control act practised in Bangladesh. (author)

  17. Effect of respiratory motion on internal radiation dosimetry

    NARCIS (Netherlands)

    Xie, Tianwu; Zaidi, Habib

    2014-01-01

    Purpose: Estimation of the radiation dose to internal organs is essential for the assessment of radiation risks and benefits to patients undergoing diagnostic and therapeutic nuclear medicine procedures including PET. Respiratory motion induces notable internal organ displacement, which influences

  18. Problems with radiation protection concerning volunteers accompanying radiological patients

    International Nuclear Information System (INIS)

    Adrian Daoud

    2008-01-01

    Full text: The purpose of this work is to point out, within the framework of the Radiation Protection guidelines, the irregular situation of the 'volunteer' or 'accompanying person' who accompanies anyone requiring medical treatment with ionising radiation, as well as to suggest a possible justification for such role. It should be noted that most of these persons are subject to ionising radiation without knowing anything about the effects that it could cause on them, so that their condition could be hardly considered as 'voluntary'. There are several circumstances under which the presence of accompanying persons is required, being different among them. Several examples could be mentioned such as: those who are accompanying a direct relative (family bonds), those who are acting in service during their normal work (social workers, policemen) and even those who are forced by unusual under an accidental situation. The qualitative classification that radiological protection established in society concerning radiation risks for people in general enables to set mechanisms of justification, optimisation and dose limitation for each category, being perfectly identified which of them each person belongs to. But the figure of 'accompanying person' has been excluded from such characterisation. They are subject to radiation exposure without knowing it, or without having any information concerning the potential risks. For them, no balance between the net benefit of an adequate medical treatment versus potential health detriment may be applied as for the case of a patient. Thus, their exposure could be not justified. It is not the purpose of this work to question radiological medicine or its practices, but to clarify certain aspects involving members of the public in general, patients and members of the radiological community, as well as to propose lines of action concerning this subject. We conclude that it is not the volunteer who should decide about medical actions, a role

  19. Auditoria e balanço social: o potencial intrínseco do controle social na promoção do desenvolvimento (Audit and social balance: the intrinsic potential of social control in benefiting from the development Doi: 10.5212/Emancipacao.v.14i2.0002

    Directory of Open Access Journals (Sweden)

    Airton Carlos Patzlaff

    2016-03-01

    Full Text Available Normal 0 21 MicrosoftInternetExplorer4 Resumo: O presente artigo busca elucidar a importância do controle social na promoção do desenvolvimento, discorrendo acerca de ferramentas como auditoria e Balanço Social no mister de promover um controle social efetivo. Conceitos como transparência e confiança são utilizados no artigo sob o viés do desenvolvimento, buscando alternativas e instrumentos que alavanquem a boa governança. Com efeito, nota-se que o Balanço Social surge como ferramenta essencial na captação e análise de indicadores de sustentabilidade (dimensões econômicas, sociais e ambientais, sendo possível aperfeiçoar os processos de auditoria e controle social a partir dos demonstrativos produzidos por meio deste importante instrumento de accountability. Para desenvolver a pesquisa em questão, empregou-se o método dedutivo, tendo como principais procedimentos metodológicos a pesquisa bibliográfica e documental, as quais permitiram demonstrar - ao final do estudo - como os instrumentos de controle podem contribuir para o desenvolvimento, notadamente na seara da Administração Pública.Palavras-chave: Desenvolvimento, Sustentabilidade, Transparência, Balanço Social. Abstract: This article reveals the importance of social control in the pursuit of development, highlighting tools such as Audit and Social Balance in promoting a social control effective. Concepts like transparency and trust are used in the article, seeking instruments that stimulate the good governance and the development. Finally, it is clear that the Social Balance appears as an essential tool in achieving sustainability indicators (economic, social and environmental, and can improve audit processes and social control from the demonstratives produced through this important instrument of accountability. To achieve these objectives we used the deductive method, through a bibliographic and documentary research, which demonstrated as instruments of control

  20. Towards exoskeletons with balance capacities

    NARCIS (Netherlands)

    van der Kooij, Herman; van Asseldonk, Edwin H.F.; Vlutters, Mark; González-Vargas, José; Ibáñez, Jaime; Contreras-Vidal, Jose L.; van der Kooij, Herman; Pons, José Luis

    2017-01-01

    Current exoskeletons replay pre-programmed trajectories at the actuated joints. Towards the employment of exoskeletons with more flexible and adaptive behavior, we investigate human balance control during gait. We study human balance control by applying brief force pulses at the pelvis in different