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Sample records for baculovirus-based nasal drop

  1. Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

    OpenAIRE

    Nina Werkhäuser; Andreas Bilstein; Uwe Sonnemann

    2014-01-01

    Objectives. Allergic rhinitis is a common disease with increasing prevalence and high impact on economic burden and comorbidities. As treatment with pharmacological drugs is not always satisfactory due to side effects and incomplete efficacy, alternative treatment strategies are needed. Ectoine is an osmolyte with membrane stabilizing and inflammation reducing capacities. Nasal spray and eye drops containing ectoine are promising new treatment regimens for allergic rhinitis sufferers. Design ...

  2. Appl ication of compound mint nasal drops for patients receiving sputum suction via nasal cavity Application of compound mint nasal drops for patients with sputum suction via nasal cavity%复方薄荷滴鼻液在经鼻吸痰病人中的应用

    Institute of Scientific and Technical Information of China (English)

    葛宝兰; 马莉

    2015-01-01

    Objective:To relieve the nasal mucosa bleeding and burst in patients caused by sputum suction via na-sal cavity.Methods:A total of 90 cases of elderly patients who need sputum suction via nasal cavity were divided into two groups,they separately used the compound mint nasal drops for lubrication and physiological saline for lubrication.The nasal mucosa bleeding and nasal mucosa burst of patients were observed in both groups.Re-sults:The compound mint nasal drops lubrication method can reduce the nasal cavity bleeding and nasal mucosa damage.Conclusion:The application of compound mint nasal drops used in lubrication of nasal cavity can effec-tively reduce the nasal mucosa bleeding and damage,improve the quality of sputum suction and the patient’s comfort level when Sputun suction via nasal cavity.%[目的]减轻病人因经鼻吸痰时而引起的鼻腔黏膜出血及破溃。[方法]将本科室需经鼻腔吸痰的90例老年病人分为两组,分别采用复方薄荷滴鼻液润滑鼻腔和生理盐水润滑鼻腔。观察两组病人鼻腔黏膜出血情况及鼻腔黏膜破溃情况。[结果]复方薄荷滴鼻液润滑鼻腔法可减少鼻腔出血及鼻黏膜受损。[结论]在经鼻吸痰时应用复方薄荷滴鼻液润滑鼻腔可以有效减少鼻腔黏膜出血及损伤,提高吸痰质量和病人的舒适程度。

  3. Nasal temperature drop in response to a playback of conspecific fights in chimpanzees: A thermo-imaging study.

    Science.gov (United States)

    Kano, Fumihiro; Hirata, Satoshi; Deschner, Tobias; Behringer, Verena; Call, Josep

    2016-03-01

    Emotion is one of the central topics in animal studies and is likely to attract attention substantially in the coming years. Recent studies have developed a thermo-imaging technique to measure the facial skin temperature in the studies of emotion in humans and macaques. Here we established the procedures and techniques needed to apply the same technique to great apes. We conducted two experiments respectively in the two established research facilities in Germany and Japan. Total twelve chimpanzees were tested in three conditions in which they were presented respectively with the playback sounds (Exp. 1) or the videos (Exp. 2) of fighting conspecifics, control sounds/videos (allospecific display call: Exp. 1; resting conspecifics: Exp. 2), and no sound/image. Behavioral, hormonal (salivary cortisol) and heart-rate responses were simultaneously recorded. The nasal temperature of chimpanzees linearly dropped up to 1.5 °C in 2 min, and recovered to the baseline in 2 min, in the experimental but not control conditions. We found the related changes in excitement behavior and heart-rate variability, but not in salivary cortisol, indicating that overall responses were involved with the activities of sympathetic nervous system but not with the measureable activities of the hypothalamus-pituitary-adrenal (HPA) axis. The influence of general activity (walking, eating) was not negligible but controllable in experiments. We propose several techniques to control those confounding factors. Overall, thermo-imaging is a promising technique that should be added to the traditional physiological and behavioral measures in primatology and comparative psychology. PMID:26657470

  4. EFFICACY OF TOPICAL APPLICATION OF EPHEDRINE AND FURACILIN NASAL DROPS COMBINED WITH TETRACAINE IN REDUCING COMPLICATIONS OF POSTOPERATIVE NASAL PACK REMOVAL%局部应用呋麻滴鼻液及丁卡因减少鼻腔填塞物拔除时并发症的临床分析

    Institute of Scientific and Technical Information of China (English)

    王振英; 蔡邦; 陈国锋

    2015-01-01

    Objective To assess the efficacy of topical application of Ephedrine and furacilin nasal drops combined with tetracaine in reducing complications of pack removal after nasal surgery.Methods 81caseshaving un-dergone nasal septum surgery were randomly divided into the experimental group and control group: the former were treated with Ephedrine and furacilin nasal drops combined with tetracaine and the blank control group.The occur-rence of complications at removing nasal fillers after nasal surgery was assessed.Results The hemorrhage and pain in the experimental group were significantly less than those in the blank control group (p <0.05).Conclusion top-ical application of Ephedrine and furacilin nasal drops combined with tetracaineis an effective method for reducing the pains of pack removal after nasal surgery.%目的:探索减少鼻腔填塞物拔除时并发症的方法。方法81例鼻中隔手术后患者采用随机对照的方法,通过鼻腔填塞物局部应用呋麻滴鼻液及丁卡因或空白对照,评估鼻腔填塞物拔除时的并发症发生情况。结果鼻腔填塞物局部用药组在出血及疼痛方面优于空白对照组。结论通过呋麻滴鼻液及丁卡因的局部混合应用,达到明显减少患者鼻腔填塞物拔除的痛苦的效果。

  5. Effects of Xanthium sibiricum nasal drops on allergic rhinitis in guinea pigs%复方苍耳子滴鼻剂对豚鼠变应性鼻炎的影响

    Institute of Scientific and Technical Information of China (English)

    李道佩; 戴卫波; 吴又明

    2012-01-01

    Objective To determine the effects of compound Xanthii sibiricum nasal drops on changes in symptoms and serum histamine level in allergic rhinitis guinea pig models. Methods The guinea pig nasal mucosal allergy model was established by using toluene-2,4-diisocyanate (2, 4-TDI) as a sensitizer. The level of histamine and morphohistological changes of each group were determined, with model group, positive drug group and blank control group regarded as controls. Results For nasal symptoms, both high and low dosage of compound Xanthii sibiricum nasal drops were associated with significant improvement in post-treatment total score when compared with pre- treatment levels (both P<0.05), suggesting marked recovery of overall symptoms in chronic rhinitis animal models. Both high and low dosage of compound Xanthii sibiricum nasal drops have, in terms of the impact on serum histamine lev -el, resulted in considerably lower figures than model group (P<0.05 or 0.01), indicating significant attenuation of serum histamine in chronic rhinitis animal model. Additionally, both high and low dosage of compound Xanthii sibiricum nasal drops have led to morphohistological improvements with regard to epithelial metaplasia, hyperplasia of glands, vascular hyperplasia or dilatation as well as inflammatory cell counts in nasal mucosa. Conclusion Experimental allergic rhinitis in rats may benefit considerably from compound Xanthii sibiricum nasal drops treatment.%目的 观察复方苍耳子滴鼻剂对变应性鼻炎模型豚鼠症状的变化和血清组胺含量的影响.方法 以甲苯-2,4-二异氰酸甲苯酯(TDI)作为致敏因子建立豚鼠鼻黏膜变态反应模型,以模型组、阳性药物组与空白组为对照,测定各组豚鼠鼻黏膜内组胺的含量及形态组织学的改变.结果 ①鼻部症状的改善情况:复方苍耳子滴鼻剂高、低剂量组药前总评分与药后总评分比较差异有统计学意义(P<0.05),能显著性改善慢性鼻炎模型动

  6. Nasal Physiology

    Science.gov (United States)

    ... Q&A Complications of Sinusitis Epistaxis (Nosebleeds) Allergic Rhinitis (Hay Fever) Headaches and Sinus Disease Disorders of ... of the autonomic, i.e. automatic, nervous system) controls blood flow to the nasal cavity and nasal ...

  7. Nasal Cancer

    Science.gov (United States)

    ... the way to your throat as you breathe. Cancer of the nasal cavity and paranasal sinuses is ... be like those of infections. Doctors diagnose nasal cancer with imaging tests, lighted tube-like instruments that ...

  8. Nasal polyps

    Science.gov (United States)

    ... may not have any symptoms. If polyps block nasal passages, a sinus infection can develop. Symptoms include: Runny ... steroid sprays shrink polyps. They help clear blocked nasal passages and runny nose. Symptoms return if treatment is ...

  9. Oxymetazoline Nasal Spray

    Science.gov (United States)

    Afrin® Nasal Spray ... Anefrin® Nasal Spray ... Dristan® Nasal Spray ... Mucinex® Nasal Spray ... Nostrilla® Nasal Spray ... Vicks Sinex® Nasal Spray ... Zicam® Nasal Spray ... Oxymetazoline nasal spray is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to ...

  10. Desmopressin Nasal

    Science.gov (United States)

    ... nasal spray, follow these steps: Remove the protective cap from the bottle. Press down on the pump 4 times to ... bottle in your other nostril. Replace the protective cap on the bottle. To use the rhinal tube, follow these steps: ...

  11. Nasal encephaloceles

    NARCIS (Netherlands)

    Hoving, Eelco W.

    2000-01-01

    Nasal encephaloceles can be divided into frontoethmoidal and basal encephaloceles. Both conditions are very rare, but frontoethmoidal encephaloceles show a relatively high incidence (1:5,000) in Southeast Asia. The pathogenesis of encephaloceles may be explained by a disturbance in separation of sur

  12. Nicotine Nasal Spray

    Science.gov (United States)

    Nicotine nasal spray is used to help people stop smoking. Nicotine nasal spray should be used together with a smoking cessation ... counseling, or specific behavior change techniques. Nicotine nasal spray is in a class of medications called smoking ...

  13. Nasal Wash Treatment

    Science.gov (United States)

    ... Disease Medications > Alternative Therapies > Nasal Wash Treatment Nasal Wash Treatment The Centers for Disease Control (CDC) guidelines ... increases airflow Watch How to Perform a Nasal Wash CDC Water Preparation Guidelines Wash your hands. Make ...

  14. Azelastine Nasal Spray

    Science.gov (United States)

    Astelin® Nasal Spray ... Astepro® Nasal Spray ... Azelastine comes as a nasal spray. Azelastine usually is sprayed in each nostril two times a day. Follow the directions on your prescription label carefully, and ask ...

  15. Beclomethasone Nasal Spray

    Science.gov (United States)

    Beclomethasone nasal spray is used to relieve symptoms of sneezing, runny, stuffy, or itchy nose (rhinitis) caused by hay fever, other ... nose) after nasal polyp removal surgery. Beclomethasone nasal spray should not be used to treat symptoms (e. ...

  16. Foot Drop

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Foot Drop Information Page Table of Contents (click to ... research is being done? Clinical Trials What is Foot Drop? Foot drop describes the inability to raise ...

  17. Nasal chondromesenchymal hamartoma with no nasal symptoms.

    LENUS (Irish Health Repository)

    Uzomefuna, Vincent

    2012-01-01

    The authors present a case of nasal chondromesenchymal hamartoma (NCMH) in an 8-year-old boy with a 4-month history of frontal headache and no symptoms of nasal obstruction, rhinorrhoea or postnasal drip. An ENT examination as well as ophthalmology assessment presented normal results. CT scan showed a lesion involving the sphenoid and ethmoid sinuses. The patient had an endoscopic resection of the lesion that was confirmed histologically to be a NCMH. Though NCMH is known to present usually in infants with obstructing nasal mass, an unusual presentation of a patient with throbbing headache without any nasal symptoms is reported here.

  18. Mometasone Nasal Spray

    Science.gov (United States)

    Mometasone nasal spray is used to prevent and relieve symptoms of sneezing, runny, stuffy, or itchy nose caused by hay fever ... of the lining of the nose). Mometasone nasal spray should not be used to treat symptoms (e. ...

  19. Flunisolide Nasal Spray

    Science.gov (United States)

    Flunisolide nasal spray is used to relieve symptoms of sneezing, runny, stuffy, or itchy nose caused by hay fever or other allergies. Flunisolide nasal spray should not be used to treat symptoms (e. ...

  20. Naloxone Nasal Spray

    Science.gov (United States)

    Naloxone nasal spray is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone nasal spray is in a class of medications called opiate ...

  1. Nasal mucosal biopsy

    Science.gov (United States)

    Biopsy - nasal mucosa; Nose biopsy ... to fast for a few hours before the biopsy. ... Nasal mucosal biopsy is usually done when abnormal tissue is seen during examination of the nose. It may also be done ...

  2. Bacterial Nasal Infections

    Science.gov (United States)

    ... the Nose Sinusitis Bacteria may cause pimples and boils (furuncles) to form just inside the opening of ... weeks. Nasal furuncles More serious infections result in boils (furuncles) in the nasal vestibule. Boils may develop ...

  3. Nasal Harmony in Aguaruna.

    Science.gov (United States)

    Moon, Gui-Sun

    A discussion of the nasal harmony of Aguaruna, a language of the Jivaroan family in South America, approaches the subject from the viewpoint of generative phonology. This theory of phonology proposes an underlying nasal consonant, later deleted, that accounts for vowel nasalization. Complex rules that suppose a complex system of vowel and…

  4. Nasal Tip Deficiency.

    Science.gov (United States)

    Cerkes, Nazim

    2016-01-01

    Nasal tip deficiency can be congenital or secondary to previous nasal surgeries. Underdeveloped medial crura usually present with underprojected tip and lack of tip definition. Weakness or malposition of lateral crura causes alar rim retraction and lateral nasal wall weakness. Structural grafting of alar cartilages strengthens the tip framework, reinforces the disrupted support mechanisms, and controls the position of the nasal tip. In secondary cases, anatomic reconstruction of the weakened or interrupted alar cartilages and reconstitution of a stable nasal tip tripod must be the goal for a predictable outcome. PMID:26616702

  5. Treatment of nasal hemangiomas.

    Science.gov (United States)

    Simic, R; Vlahovic, A; Subarevic, V

    2009-10-01

    Hemangiomas are the most common soft tissue tumors of infancy. Almost 60% of these tumors develop in the head and neck region. Nasal hemangiomas, distort human physiognomy and leave long lasting psychological sequelae. Conservative approach (intralesional corticosteroids, laser) may accelerate involution. Proponents of an early surgery suggest that aesthetic improvement during a critical period in child development can be achieved. Fourteen patients with nasal hemangioma were treated during 5-year period (2003-2007) with intralesional corticosteroids, lenticular excision, open rhinoplasty excision, and circular excision with "purse string suture". The first line of treatment for large nasal hemangiomas is intralesional corticosteroids. Excision is indicated for small hemangiomas, while subtotal excision is preferable for large nasal hemangiomas. Circular excision and "purse string suture" is appropriate for prominent hemangiomas with predominant deep component. In our opinion surgery with maximal care for nasal architecture is the treatment option for nasal hemangioma. PMID:19656579

  6. Olopatadine Nasal Spray

    Science.gov (United States)

    Olopatadine nasal spray is used to relieve sneezing and a stuffy, runny or itchy nose caused by allergic rhinitis (hay fever). ... Olopatadine comes as a liquid to spray in the nose. Olopatadine nasal spray ... twice daily. Follow the directions on your prescription label carefully, ...

  7. Butorphanol Nasal Spray

    Science.gov (United States)

    Butorphanol nasal spray is used to relieve moderate to severe pain. Butorphanol is in a class of medications called opioid agonist- ... Butorphanol nasal spray comes as a solution (liquid) to spray in the nose. It is usually used as needed for pain, ...

  8. Ketorolac Nasal Spray

    Science.gov (United States)

    Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class ... Nasal ketorolac comes as a liquid to spray in the nose. It is usually used once every 6 to 8 hours as needed to control pain for up to 5 days. ...

  9. Calcitonin Salmon Nasal Spray

    Science.gov (United States)

    ... pump is now primed. To use the nasal spray, follow these steps: Keep your head up and place the nozzle in one nostril. Press down on the pump ... reach of children. Store unopened calcitonin salmon nasal spray in the ... the nozzle clean. Opened calcitonin salmon stored at room temperature ...

  10. Nasal mucociliary transport in laryngectomees

    International Nuclear Information System (INIS)

    A study has been carried out to assess the mucociliary function of nasal mucosa in 30 patients: 16 had undergone surgery due to larynx malignancy and the remaining 14 were divided in two groups. The first group was composed of seven patients suffering from larynx cancer but not operated, and the second group of seven had pathology not related to the airways (control group). The method used a sup(99m)technetium sulphur colloid drop deposited on the nasal mucosa of one nostril. To calculate the rate of transport, a new method of quantification has been introduced, based on the formation of a parametric image. The mean velocity in laryngectomees was 3.6 mm/min (range 1.1-6.4). It was compared with the group of 14 patients without tracheostomy (mean 5.3, range 3.3-8.2). An impaired student's-t-test gave a significant difference between both groups (P<0.005). The comparison between patients with nonoperated larynx cancer and normals have a nonsignificant difference. The 16 operated patients were arbitrarily divided into two groups as per the time elapsed from laryngectomy; seven were studied within the first 3 years of operation and seven other patients after this term. The comparison between them was not significant. (orig.)

  11. Nasal mucociliary transport in laryngectomees

    Energy Technology Data Exchange (ETDEWEB)

    Pavia, J.; Garcia, A.; Abello, R.; Herranz, R.; Franch, M.; Espana, R. de

    1986-04-01

    A study has been carried out to assess the mucociliary function of nasal mucosa in 30 patients: 16 had undergone surgery due to larynx malignancy and the remaining 14 were divided in two groups. The first group was composed of seven patients suffering from larynx cancer but not operated, and the second group of seven had pathology not related to the airways (control group). The method used a sup(99m)technetium sulphur colloid drop deposited on the nasal mucosa of one nostril. To calculate the rate of transport, a new method of quantification has been introduced, based on the formation of a parametric image. The mean velocity in laryngectomees was 3.6 mm/min (range 1.1-6.4). It was compared with the group of 14 patients without tracheostomy (mean 5.3, range 3.3-8.2). An impaired student's-t-test gave a significant difference between both groups. The comparison between patients with nonoperated larynx cancer and normals have a nonsignificant difference. The 16 operated patients were arbitrarily divided into two groups as per the time elapsed from laryngectomy; seven were studied within the first 3 years of operation and seven other patients after this term. The comparison between them was not significant.

  12. Pressure Drop

    Science.gov (United States)

    Lawson, Mike

    2010-01-01

    Mike Lawson briefly discussed pressure drop for aerospace applications and presented short stories about adventures experienced while working at NASA and General Dynamics, including exposure to technologies like the Crew and Equipment Translation Aid (CETA) cart and the SWME.

  13. Protective efficacy of a human endogenous retrovirus envelope-coated, nonreplicable, baculovirus-based hemagglutin vaccine against pandemic influenza H1N1 2009.

    Science.gov (United States)

    Choi, Jae-Yoo; Gwon, Yong-Dae; Kim, Jeong-Ki; Cho, Yeon-Dong; Heo, Yoon-Ki; Cho, Han-Sam; Choi, Tae-Jin; Poo, Ha-Ryoung; Oh, Yu-Kyoung; Kim, Young Bong

    2013-01-01

    Despite the advantages of DNA vaccines, overcoming their lower efficacy relative to that of conventional vaccines remains a challenge. Here, we constructed a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus-based HA vaccine against swine influenza A/California/04/2009(H1N1) hemagglutin (HA) (AcHERV-sH1N1-HA) as an alternative to conventional vaccines and evaluated its efficacy in two strains of mice, BALB/c and C57BL/6. A commercially available, killed virus vaccine was used as a positive control. Mice were intramuscularly administered AcHERV-sH1N1-HA or the commercial vaccine and subsequently given two booster injections. Compared with the commercial vaccine, AcHERV-sH1N1-HA induced significantly higher levels of cellular immune responses in both BALB/c and C57BL/6 mice. Unlike cellular immune responses, humoral immune responses depended on the strain of mice. Following immunization with AcHERV-sH1N1-HA, C57BL/6 mice showed HA-specific IgG titers 10- to 100-fold lower than those of BALB/c mice. In line with the different levels of humoral immune responses, the survival of immunized mice after intranasal challenge with sH1N1 virus (A/California/04/2009) depended on the strain. After challenge with 10-times the median lethal dose (MLD50) of sH1N1 virus, 100% of BALB/c mice immunized with the commercial vaccine or AcHERV-sH1N1-HA survived. In contrast, C57BL/6 mice immunized with AcHERV-sH1N1-HA or the commercial vaccine showed 60% and 70% survival respectively, after challenge with sH1N1 virus. In all mice, virus titers and results of histological analyses of lung tissues were consistent with the survival data. Our results indicate the importance of humoral immune response as a major defense system against influenza viral infection. Moreover, the complete survival of BALB/c mice immunized with AcHERV-sH1N1-HA after challenge with sH1N1 virus suggests the potential of baculoviral vector-based vaccines to achieve an efficacy comparable to

  14. Protective efficacy of a human endogenous retrovirus envelope-coated, nonreplicable, baculovirus-based hemagglutin vaccine against pandemic influenza H1N1 2009.

    Directory of Open Access Journals (Sweden)

    Jae-Yoo Choi

    Full Text Available Despite the advantages of DNA vaccines, overcoming their lower efficacy relative to that of conventional vaccines remains a challenge. Here, we constructed a human endogenous retrovirus (HERV envelope-coated, nonreplicable, baculovirus-based HA vaccine against swine influenza A/California/04/2009(H1N1 hemagglutin (HA (AcHERV-sH1N1-HA as an alternative to conventional vaccines and evaluated its efficacy in two strains of mice, BALB/c and C57BL/6. A commercially available, killed virus vaccine was used as a positive control. Mice were intramuscularly administered AcHERV-sH1N1-HA or the commercial vaccine and subsequently given two booster injections. Compared with the commercial vaccine, AcHERV-sH1N1-HA induced significantly higher levels of cellular immune responses in both BALB/c and C57BL/6 mice. Unlike cellular immune responses, humoral immune responses depended on the strain of mice. Following immunization with AcHERV-sH1N1-HA, C57BL/6 mice showed HA-specific IgG titers 10- to 100-fold lower than those of BALB/c mice. In line with the different levels of humoral immune responses, the survival of immunized mice after intranasal challenge with sH1N1 virus (A/California/04/2009 depended on the strain. After challenge with 10-times the median lethal dose (MLD50 of sH1N1 virus, 100% of BALB/c mice immunized with the commercial vaccine or AcHERV-sH1N1-HA survived. In contrast, C57BL/6 mice immunized with AcHERV-sH1N1-HA or the commercial vaccine showed 60% and 70% survival respectively, after challenge with sH1N1 virus. In all mice, virus titers and results of histological analyses of lung tissues were consistent with the survival data. Our results indicate the importance of humoral immune response as a major defense system against influenza viral infection. Moreover, the complete survival of BALB/c mice immunized with AcHERV-sH1N1-HA after challenge with sH1N1 virus suggests the potential of baculoviral vector-based vaccines to achieve an efficacy

  15. Snoring and Nasal Congestion

    Science.gov (United States)

    ... the noisy breathing caused by vibrations of the upper airway during sleep. In contrast to snoring (noisy but ... can even require a tracheostomy to bypass the upper airway obstruction. If you suffer from nasal congestion, snoring, ...

  16. Fentanyl Nasal Spray

    Science.gov (United States)

    Fentanyl nasal spray is used to treat breakthrough pain (sudden episodes of pain that occur despite round ... effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called narcotic ( ...

  17. Beclomethasone Nasal Spray

    Science.gov (United States)

    ... symptoms may begin to improve a few days after you first use beclomethasone, but it may take 1 ... your symptoms get worse or do not improve after you use beclomethasone nasal spray for 3 weeks. If ...

  18. Fracture Nasal Bone

    OpenAIRE

    Balasubramanian, Thiagarajan; Venkatesan, Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and u...

  19. FRACTURE NASAL BONES

    OpenAIRE

    Balasubramanian Thaigarajan; Venkatesan Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography a...

  20. Pathophysiology of nasal congestion

    Directory of Open Access Journals (Sweden)

    Robert M Naclerio

    2010-02-01

    Full Text Available Robert M Naclerio1, Claus Bachert2, James N Baraniuk31University of Chicago, Department of Surgery, Section of Otolaryngology – Head and Neck Surgery, Chicago, Illinois, USA; 2University of Ghent, Ghent, Belgium; 3Georgetown University, Washington, DC, USAAbstract: Nasal congestion is a common symptom in rhinitis (both allergic and nonallergic, rhinosinusitis and nasal polyposis. Congestion can also be caused by physical obstruction of nasal passages and/or modulation of sensory perception. Mucosal inflammation underlies many of the specific and interrelated factors that contribute to nasal congestion, as well as other symptoms of both allergic rhinitis and rhinosinusitis. A wide range of biologically active agents (eg, histamine, tumor necrosis factor-α, interleukins, cell adhesion molecules and cell types contribute to inflammation, which can manifest as venous engorgement, increased nasal secretions and tissue swelling/edema, ultimately leading to impaired airflow and the sensation of nasal congestion. Inflammation-induced changes in the properties of sensory afferents (eg, expression of peptides and receptors that innervate the nose can also contribute to altered sensory perception, which may result in a subjective feeling of congestion. Increased understanding of the mechanisms underlying inflammation can facilitate improved treatment selection and the development of new therapies for congestion.Keywords: allergic rhinitis, congestion, obstruction, pathophysiology, rhinosinusitis

  1. Nasal septum extramedullary plasmacytoma

    Directory of Open Access Journals (Sweden)

    Belić Branislav

    2013-01-01

    Full Text Available Introduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP. EMP represents less than 1% of all head and neck malignancies. Case report. We presented a case of EMP of the nasal septum in a 44-year-old male who had progressive difficulty in breathing through the nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed dark red, soft, polypoid tumor in the last third of the right nasal cavity arising from the nasal septum. The biopsy showed that it was plasmacytoma. Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy, skeletal survey and other screening tests failed to detect multiple myeloma. This confirmed the diagnosis of EMP. The mass was completely removed via an endoscopic approach, and then, 4 week later, radiotherapy was conducted with a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up period. Conclusion. EMP of the nasal cavity, being rare and having long natural history, represents a diagnostic and therapeutic challenge for any ear, nose and throat surgeon. Depending on the resectability of the lesion, a combined therapy is the accepted treatment.

  2. Nasal palatal: segment complex

    Directory of Open Access Journals (Sweden)

    Lourdes Romera

    2015-10-01

    Full Text Available This paper focuses on the nature of a segment which is always problematical —the palatal nasal. Phonetic results found in the acoustic, perceptive and articulate spheres, showing the different features of this nasal with regards to others, are the point of departure for a brief reflection on the phonological nature of this segment, taking into account the feature geometry and the articulatory phonology. It concludes by considering the palatal nasal /?/ as a complex segment formed by /n+j/ and the imputation, to temporary effects, of a degree of major o minor assimilation and gestural overlapping during effective perception of /?/, of /n+j/ or of /n+i/.

  3. Dihydroergotamine Injection and Nasal Spray

    Science.gov (United States)

    Migranal® Nasal Spray ... inject subcutaneously (under the skin) and as a spray to be used in the nose. It is ... that you know how to use the nasal spray or administer the injection correctly. After that, you ...

  4. OUTCOMES FOLLOWING NASAL SURGERY WITH AND WITHOUT POSTOPERATIVE NASAL DRESSINGS

    Directory of Open Access Journals (Sweden)

    Surya Prakasa Rao

    2015-02-01

    Full Text Available PURPOSE OF STUDY: Nasal dressing following nasal surgery in an attempt to prevent postoperative bleeding and to modulate the wound healing process. Experience with postoperative nasal dressings in otolaryngologic literature spans more than half a century; despite of this, there is still little agreement between the surgeons on the appropriate choice of nasal dressings following nasal surgery , or whether nasal dressings are required at all. This paper briefly reviews the comparative study between the postoperative case s wi th and without nasal dressings. STUDY DESIGN: It is a prospective study carried out in a te rtiary care, teaching hospital. MATERIALS AND METHODS: A prospective evaluation of patients who underwent nasal surgery at tertiary teaching hospital setting bet ween February 2013 to June 2014 was performed. Nasal dressing was done in some cases who underwent nasal surgery and no dressing was done in some cases. The comparative results between the cases with and without nasal packing in terms of Postoperative blee ding, Adhesion formation, Middle turbinate lateralization were studied. RESULTS: Out of 160 patients included in this study, nasal dressing postoperatively was done in 92 cases and 68 cases were not packed postoperatively. In terms of postoperative bleedin g there is no significant difference between the cases with packs (5.43% and without pack (5.88%. Postoperative Adhesion formation was less in cases without nasal packing ( 2.94% than in cases with nasal dressing ( 8.7%. Middle turbinate lateralization i s also less in cases without nasal packing ( 8.82% than in cases with nasal packing (17.5%. CONCLUSION: The decision as to whether to pack the nose after nasal surgery remains controversial. There has been an increasing tendency to move away from removabl e nasal dressings due to discomfort and bleeding upon removal and also postoperative adhesions. This study showcases that there is no considerable difference in

  5. FRACTURE NASAL BONES

    Directory of Open Access Journals (Sweden)

    Balasubramanian Thaigarajan

    2013-03-01

    Full Text Available Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and ultrasound in their diagnosis and their management.

  6. Nasalance Norms in Greek Adults

    Science.gov (United States)

    Okalidou, Areti; Karathanasi, Asimina; Grigoraki, Eleni

    2011-01-01

    The purposes of this study were to derive nasalance norms for monolingual Greek speakers, to examine nasalance scores as a function of gender and to draw cross-linguistic comparisons based on normative data. Participants read aloud a corpus of linguistic material, consisting of (1) a nasal text, an oral text and a balanced text; (2) a set of nasal…

  7. Cosmetic and Functional Nasal Deformities

    Science.gov (United States)

    ... nasal complaints. Nasal deformity can be categorized as “cosmetic” or “functional.” Cosmetic deformity of the nose results in a less ... taste , nose bleeds and/or recurrent sinusitis . A cosmetic or functional nasal deformity may occur secondary to ...

  8. Dropped Ceiling

    OpenAIRE

    Tabet, Rayyane

    2012-01-01

    On December 2nd 1950 the first drop of Saudi oil arrived to Lebanon via the newly constructed Trans-Arabian Pipeline, the world's longest pipeline and the largest American private investment in a foreign land. The 30inch wide structure which spanned 1213 kilometers passing through Saudi Arabia, Jordan, and Syria to end in Lebanon had required 3 years of planning and surveying, 2 years of installation, the fabrication of 256,000 tons of steel tubes, the employment of 30,000 workers, the ratifi...

  9. Ciclesonide Nasal Spray

    Science.gov (United States)

    Ciclesonide nasal spray is used to treat the symptoms of seasonal (occurs only at certain times of the year), and perennial ( ... Ciclesonide comes as a solution (liquid) to spray in the nose. It is usually sprayed in each nostril once daily. Use ciclesonide at around the same time every day. Follow the ...

  10. Naloxone Nasal Spray

    Science.gov (United States)

    ... symptoms, he or she should give you your first naloxone dose and then call 911 immediately. After receiving the naloxone nasal spray, ... the person on their side (recovery position) and call for emergency medical ... after giving the first naloxone dose. If the person does not respond ...

  11. Assessment of nasal obstruction with flexible nasal endoscopy

    International Nuclear Information System (INIS)

    Objective was to report the value of nasal endoscopy as an outpatient procedure in the diagnosis of posterior nasal obstruction. Over one year period, from March 2002 to March 2003, we evaluated 130 adult patients that attended the Ear, Nose and Throat Department of Sohag University Hospital in Egypt with persistent nasal obstruction via anterior rhinoscopy and flexible nasopharyngoscopy. We reported the cause and site of obstruction in relation to the choanae. We confirmed the diagnosis by CT scanning, rigid endoscopic examination under general anesthesia, and histopathological analysis of biopsies taken. Forty-six percent of our cases had posterior nasal obstruction, 43.5% due to post-choanal lesions (mainly adenoid), 33% due to pre-choanal lesions (mainly choanal polyps), and 23.5% due to choanal lesions (mainly choanal adenoid). We conclude that flexible nasal endoscopy is superior to visual examination in the evaluation of nasal obstruction; hence, we recommend its routine use. (author)

  12. Nasal Bridge Intramuscular Hemangioma

    OpenAIRE

    Zulkifli Hamir Basah; Irfan Mohamad; Ramiza Ramza Ramli; Maha Khadum Gayadh; Samarendra Singh Mutum

    2015-01-01

    Intramuscular haemangioma (IMH) is a benign mesenchymal tumour. It appears as a deep, nontender mass within the soft tissue, particularly in the extremities. This tumour may not be obvious on clinical examination. Head and neck IMHs represent only 13.5% of the total IMHs. The most common site for a head and neck IMH is the masseter muscle, followed by trapezius, sternocleidomastoid, and very rarely temporalis muscle. We present a patient with left nasal bridge swelling which was excised and h...

  13. Congenital nasal lipoma

    International Nuclear Information System (INIS)

    The authors describe a rare case of congenital lipoma of a nose and nasopharynx in a 7 months old girl. The tumor, about 7 x 2 cm was situated in the right nasal cavity and the nasopharynx. The tumor caused complete obstruction of the right side of the nose. After CT diagnosis the tumor was excised from intranasal approach. Histological examination disclosed lipoma. The duration of follow up was 10 months without any sight of recurrence. (author)

  14. Health risks associated with inhaled nasal toxicants

    NARCIS (Netherlands)

    Feron, V.J.; Arts, J.H.E.; Kuper, C.F.; Slootweg, P.J.; Woutersen, R.A.

    2001-01-01

    Health risks of inhaled nasal toxicants were reviewed with emphasis on chemically induced nasal lesions in humans, sensory irritation, olfactory and trigeminal nerve toxicity, nasal immunopathology and carcinogenesis, nasal responses to chemical mixtures, in vitro models, and nasal dosimetry- and me

  15. Numerical investigation of the flow field in realistic nasal septal perforation geometry.

    Science.gov (United States)

    Faramarzi, Mohammad; Baradaranfar, Mohammad Hossein; Abouali, Omid; Atighechi, Saeid; Ahmadi, Goodarz; Farhadi, Pejman; Keshavarzian, Erfan; Behniafard, Nasim; Baradaranfar, Amin

    2014-07-01

    The computational fluid dynamics (CFD) are used to evaluate the physiological function of the nose. We evaluated the aerodynamics of the nasal cavity in a patient with septal perforation (SP), pre- and postvirtual repair. Three-dimensional nasal models were reconstructed, and then a wide range of the pressure drops and flow rates were analyzed. The airflow velocity is higher in the central region and is lower around the boundary of the SP. The air velocity in the SP increases as the pressure drop increases. Furthermore, at the anterior part of the SP, the shear stress is higher in the upper part. In addition, the repair of SP does not affect the total nasal airflow rate and the velocity contour patterns. The potential usage of the CFD technique as a predictive technique to explore the details and a preoperative assessment tool to help in clinical decision making in nasal surgery is emphasized. PMID:24988523

  16. [Weiss' nasal lymphoma (histiocytic, malignant)].

    Science.gov (United States)

    Pons, S; Ortiz Medina, A

    1984-01-01

    We presented a patient with a deforming and necrotizing syndrome of the nasal pyramid. The histopathology demonstrated a lymphoma. The original works of Weiss are related. The diseases is characterized by: ecotaxis of the nasal pyramid, localized persistency during a long time, malaise in advanced studies and sensibility to radiations. We proposed the name linfoma histiocitico maligno nasal de Weiss and consider it as a autonomous entity. PMID:6384693

  17. Nasendoscopy for unusual nasal symptoms

    OpenAIRE

    Vedasalam, S; Sipaul, F.; Hill, A.; Porter, G.

    2010-01-01

    A 20-year-old woman who was fit and well presented with a history of left nasal blockage for 2 years. She was noted on anterior rhinoscopy to have nasal septal deviation towards the left. She was listed for septoplasty with the aim of relieving nasal obstruction. At operation she was found to have a mildly deviated septum to the left. There was also a rhinolith in the left nostril posterior to the deviated septum (figure 1). Following removal of the rhinolith, her nasal airway appeared adequa...

  18. On the relation of nasal cycling with nasal airway dimensions

    International Nuclear Information System (INIS)

    The size and configuration of the nasal airways of humans change with time as a result of the normal process of congestion/decongestion of the erectile tissue of the nasal mucosa. To determine the extent to which airway areas change in vivo, we used magnetic resonance imaging (MRI) to quantitate both the cross-sectional area and perimeter of coronal sections of the entire nasal airway of a human subject. Changes in airway size or patency were indexed to measured changes in unilateral nasal airway resistance determined by posterior rhino manometry. The results of this study in which two MRI scans were performed for presumed left-side patency and two for right-side patency, showed that changes in nasal airway resistance were difficult to ascribe to systematic changes In the sizes of the airways. (author)

  19. COMPARATIVE THERAPEUTIC EFFECTS OF VARIOUS MORPHOLOGICAL FORMS OF NASYA (NASAL ROUTE OF DRUG DELIVERY IN PRATISHYAYA (RHINOSINUSITIS WITH REFERENCE TO NASAL MUCO-CILIARY FUNCTION

    Directory of Open Access Journals (Sweden)

    Bhardwaj Atul

    2012-10-01

    Full Text Available Different morphological forms of Nasyas (Nasal route of drug administration in Ayurveda like Taila and Ghrita (lipid based nasal drops, churna (dry fine powder and Avpeeda nasya (Aqueous based medicated decoction nasal drops are commonly used as nasal drugs for the management of rhinological disorders in Ayurveda and they distinctly behave differently in the nasal cavity when introduced. This present study explores how these different morphological forms of Nasyas effects the nasal health and mucociliary mechanism in the patients of Pratishyaya i.e. Rhinosinusitis with the help of Goldman’s saccharin test which is carried out at various stages of this study. Clinically, endoscopically and radiologically diagnosed patients of Pratishyaya i.e. rhinosinusitis, satisfying the inclusion criteria were divided randomly by table method into four groups. A total of 40 patients were subjected in this trial after ramification into four trial groups with 10 patients in each group. Anu taila nasya, Shadbindu ghrita nasya, Katphala churna nasya and Pippali Avapeeda nasya respectively were selected for the present study in trial groups I – IV as they are the most frequently prescribed drugs in Ayurveda (Indian system of medicine for the management of the disease Pratishyaya i.e. Rhinosinusitis. These selected drugs subtly represent medicated oils/lipids, powder insufflations (errhines and medicated aqueous base decoction form of nasal drug administration when visualized in morphological appearance and modern perspective. Goldman’s saccharin test, which is used for the present study is a gold standard test for the evaluation of nasal mucociliary function and is directly related to nasal health. Powder form of nasal administered drug i.e. Katphala Churna nasya (powder form was found to be most effective in improvement of endoscopic and radiological parameters of rhinosinusitis. Mucoadhesive properties of Anu Taila nasya and Shadbindu ghrita nasya (both

  20. Nasal hump: Five year analysis

    Directory of Open Access Journals (Sweden)

    Kljajić Vladimir

    2010-01-01

    Full Text Available Introduction The nose has a prominent central position in the face and therefore it considerably contributes to the esthetic appearance and facial harmony. On the anterior view, the face is dominated by the nasal length and width, as well as medial location. On the lateral view, the nasal dorsum is most important; although it is the dimension we cannot see ourselves, it is the most common cause of surgery. Material and methods This five-year retrospective study included 216 patients of both sexes; their average age was 22 years, and they underwent surgery at the Ear, Throat and Nose Clinic in Novi Sad in the period from 2001 to 2006. There were 89 male, and 127 female patients. Results Most patients were aged 18 - 22 years (57%. A nasal pyramid deformity with septal deviation was present in 81.1% of patients, whereas 18.9% (41 patients presented only with a nasal pyramid deformity. Out of the total number of patients, 24 patients had both nasal kyphosis and scoliosis. All patients underwent closed rhinoplasty with obligatory correction of the tip of the nose. The nasal hump removal with lateral osteotomy was also performed in all patients. Two patients underwent reoperation, due to small dorsal humps within the cartilage, while one patient had a postoperative septal perforation. One patient presented with a postoperative abscess of the nasal dorsum, which was conservatively managed. Conclusion Nasal hump is the most common nasal pyramid deformity, often without a nasal septum deviation. It is quite easily treated by surgery. Two patients have already undergone reoperation with good results, and two patients had postoperative complications. Postoperative complications were recorded in 1,85% of patients.

  1. Dilating Eye Drops

    Science.gov (United States)

    ... Frequently Asked Questions Español Condiciones Chinese Conditions Dilating Eye Drops En Español Read in Chinese What are dilating eye drops? Dilating eye drops contain medication to enlarge ( ...

  2. Definitive magnetic nasal prosthesis for partial nasal defect

    Directory of Open Access Journals (Sweden)

    E Nagaraj

    2011-01-01

    Full Text Available Maxillofacial trauma refers to any injury to the face or jaw caused by physical force, trauma, the presence of foreign objects, animal or human bites, and burns. Facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potential compromises in quality of life. Restoration of facial defects, especially nasal defects, is a difficult challenge for both the surgeon and the prosthodontist. Here is a case report of partial nasal defect caused by trauma, rehabilitated with a magnetic nasal prosthesis made with silicone elastomers using mechanical and anatomical retentive aids.

  3. Pathogenesis of nasal polyposis.

    Science.gov (United States)

    Hulse, K E; Stevens, W W; Tan, B K; Schleimer, R P

    2015-02-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition that affects a large proportion of the population world-wide and is associated with high cost of management and significant morbidity. Yet, there is a lack of population-based epidemiologic studies using current definitions of CRSwNP, and the mechanisms that drive pathogenesis in this disease remain unclear. In this review, we summarize the current evidence for the plethora of factors that likely contribute to CRSwNP pathogenesis. Defects in the innate function of the airway epithelial barrier, including diminished expression of antimicrobial products and loss of barrier integrity, combined with colonization by fungi and bacteria likely play a critical role in the development of chronic inflammation in CRSwNP. This chronic inflammation is characterized by elevated expression of many key inflammatory cytokines and chemokines, including IL-5, thymic stromal lymphopoietin and CCL11, that help to initiate and perpetuate this chronic inflammatory response. Together, these factors likely combine to drive the influx of a variety of immune cells, including eosinophils, mast cells, group 2 innate lymphoid cells and lymphocytes, which participate in the chronic inflammatory response within the nasal polyps. Importantly, however, future studies are needed to demonstrate the necessity and sufficiency of these potential drivers of disease in CRSwNP. In addition to the development of new tools and models to aid mechanistic studies, the field of CRSwNP research also needs the type of robust epidemiologic data that has served the asthma community so well. Given the high prevalence, costs and morbidity, there is a great need for continued research into CRS that could facilitate the development of novel therapeutic strategies to improve treatment for patients who suffer from this disease. PMID:25482020

  4. Keratoacanthoma: an unusual nasal mass.

    Science.gov (United States)

    Sazafi, M S; Salina, H; Asma, A; Masir, N; Primuharsa Putra, S H A

    2013-12-01

    We report a case of keratoacanthoma in a non-sun-exposed nasal vestibule of an 84-year-old man. He presented with a progressively growing left nasal mass that had been present for 8 months. Examination showed a non-tender protruding mass arising from medial vestibular wall of the left nostril. Histopathology indicated it was a keratoacanthoma. In an elderly patient with a history of a progressively growing mass in the nose, a differential diagnosis of malignancy should be ruled out, and histological conformation is essential. To our knowledge, only a very small number of cases of nasal vestibular keratoacanthoma have been reported. PMID:24376301

  5. Measurement of nasal mucociliary clearance.

    OpenAIRE

    Corbo, G M; Foresi, A; Bonfitto, P; Mugnano, A; Agabiti, N.; Cole, P J

    1989-01-01

    The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance. Nasal mucociliary clearance times were analysed according to clinical history (asthma, rhinitis, asthma with rhinitis, and acute upper respiratory tract infections), laboratory findings (positive skin test respons...

  6. Bilateral cleft lip nasal deformity

    OpenAIRE

    Singh Arun; Nandini R.

    2009-01-01

    Bilateral cleft lip nose deformity is a multi-factorial and complex deformity which tends to aggravate with growth of the child, if not attended surgically. The goals of primary bilateral cleft lip nose surgery are, closure of the nasal floor and sill, lengthening of the columella, repositioning of the alar base, achieving nasal tip projection, repositioning of the lower lateral cartilages, and reorienting the nares from horizontal to oblique position. The multiplicity of procedures in the li...

  7. A entomoftorose nasal

    Directory of Open Access Journals (Sweden)

    Zilton A. Andrade

    1972-10-01

    Full Text Available São apresentados os dados clínico-patológicos de dois casos de entomoftorose nasal, nova doença humana causada por um ficomiceto - Entomophthora coronata. Os pacientes, uma menina e um homem, com 8 e 44 anos de idade respectivamente, apresentaram doença localizada, com nódulos no nariz e região paranasal, edema e deformação da face. O parasito foi isolado do primeiro caso, mas todas as tentativas para isolá-lo no segundo caso resultaram negativas. Histologicamente, havia reação granulomatosa, fibrose e edema, em torno de hifas não septadas, as quais exibiam envólucro eosinófilo amorfo em torno. Foram demonstrados anticorpos circulantes contra, as hifas do E. coronata no soro de um dos pacientes. O material eosinófilo em torno das hifas continha fibrina e material auto-fluorescente sob luz ultra-violeta, provavelmente lipofuscina, mas não foram demonstrados anticorpos ou antígenos nesta área. A apresentação destes casos, os primeiros a serem descritos no Brasil, é acompanhado, de uma revisão geral do assunto, pois tal poderá vir a ser de interesse para aqueles que estudam os problemas da patologia tropical em nosso meio.

  8. Reduction in drop size of ophthalmic topical drop preparations and the impact of treatment

    Directory of Open Access Journals (Sweden)

    Shiva Kumar

    2011-01-01

    Full Text Available In this work we devised a method to create smaller eye drops of the glaucoma medication timolol maleate by altering the dropper tip design and changing the physical properties of the formulation. Most ocular diseases are treated with topical application of eye drops. After instillation of an eye drop, typically, less than 5% of the applied drug penetrates the cornea and reaches the intraocular tissues; the major fraction of the instilled drug is absorbed and enters the systemic circulation. Ophthalmic solutions are available in multidose or single-dose glass/plastic dropper bottles that deliver drops with a volume that ranges from 25 μL to 70 μL (average 40 μL. Because of the low capacity of the precorneal area, the optimal drop volume is about 20 μL; with larger volumes there is the risk of adverse systemic effects due to absorption of the drug via the nasal mucosa. Thus, both from the biopharmaceutical and economic point of view, drops of only 5-15 mL volume should be instilled into the eye. In this present work we devised a method to reduce the size of the drop by inserting a glass capillary tube into the dropper tip and by changing the physical properties of the formulation (by altering the concentration of Tween 80™, i.e., 0.05% and 0.1% of Tween 80™. We measured the drop sizes of the different timolol eye drop formulations available in the market and estimated the yearly cost of the medications. Our timolol maleate formulation with 0.1% concentration of Tween 80™ delivered through the dropper tip with the inserted glass capillary was shown to be better than the other formulations available in the market in terms of ability to deliver smaller drops, meaning that each bottle would last longer and that the yearly cost of treatment would be lower.

  9. TEFLON NASAL SPLINTS IN NASAL SURGERIES: ADVANTAGES OVER CONVENTIONAL NASAL PACKING

    OpenAIRE

    Sudhir M Naik; Ravishankar, B.; T Shashikumar; T Deekshith; C Sherry; N Pooja; P.Sathya

    2014-01-01

    Background &Objectives: Nasal splints have long been used to prevent post operative nasal adhesions in septal surgery. But its efficacy in reducing adhesions and residual deviations are still controversial. Teflon is an inert material used as septal splints with sieves are used in our study as splints. Materials and methods: This is a comparative case series study done in 214 cases of septoplasties. 116 postoperative cases were packed with framycetin packs only and the other 98 cases ...

  10. Image diagnosis of nasal bone fracture

    International Nuclear Information System (INIS)

    Twenty cases of nasal bone fractures were evaluated as to the types of fractures based upon HRCT findings. Conventional X-Ray films for nasal bones were analyzed and compared with HRCT findings. Nasal bone fractures were classified into lateral and frontal fractures. HRCT images were evaluated in three planes including upper, middle and lower portions of the nasal bone. Fractures favored males of teens. Lateral fracture gave rise to the fractures of the nasal bone opposite to the external force, loosening of the ipsilateral nasomaxillary sutures and fractures of the frontal process of the maxilla. Conventional X-Ray films were reevaluated after HRCT evaluation and indications of nasal bone fractures were determined. In addition to the discontinuity of the nasal dorsum, fracture lines parallel to and beneath the nasal dorsum and indistinct fracture lines along the nasomaxillary sutures are the indication of nasal bone fractures by conventional X-Ray films. (author)

  11. Bilateral cleft lip nasal deformity

    Directory of Open Access Journals (Sweden)

    Singh Arun

    2009-01-01

    Full Text Available Bilateral cleft lip nose deformity is a multi-factorial and complex deformity which tends to aggravate with growth of the child, if not attended surgically. The goals of primary bilateral cleft lip nose surgery are, closure of the nasal floor and sill, lengthening of the columella, repositioning of the alar base, achieving nasal tip projection, repositioning of the lower lateral cartilages, and reorienting the nares from horizontal to oblique position. The multiplicity of procedures in the literature for correction of this deformity alludes to the fact that no single procedure is entirely effective. The timing for surgical intervention and its extent varies considerably. Early surgery on cartilage may adversely affect growth and development; at the same time, allowing the cartilage to grow in an abnormal position and contributing to aggravation of deformity. Some surgeons advocate correction of deformity at an early age. However, others like the cartilages to grow and mature before going in for surgery. With peer pressure also becoming an important consideration during the teens, the current trend is towards early intervention. There is no unanimity in the extent of nasal dissection to be done at the time of primary lip repair. While many perform limited nasal dissection for the fear of growth retardation, others opt for full cartilage correction at the time of primary surgery itself. The value of naso-alveolar moulding (NAM too is not universally accepted and has now more opponents than proponents. Also most centres in the developing world have neither the personnel nor the facilities for the same. The secondary cleft nasal deformity is variable and is affected by the extent of the original abnormality, any prior surgeries performed and alteration due to nasal growth. This article reviews the currently popular methods for correction of nasal deformity associated with bilateral cleft lip, it′s management both at the time of cleft lip repair

  12. Nasal trauma: Primary reconstruction with open rhinoplasty.

    Science.gov (United States)

    Konstantinidis, I; Malliari, H; Metaxas, S

    2011-01-01

    Due to the prominent location of the nose, the most common facial traumas are nasal injuries. Although nasal traumas usually require staged intervention at a later period of time, in selected cases, primary reconstruction can be effective. A 20-year-old man who was referred from the emergency department with nasal trauma is presented. He reported a fall after feeling unsteady, which caused a direct nasal injury. Clinical examination revealed septal fracture with obstruction of the left nasal cavity and deformity of the nasal pyramid (inverted V deformity). The patient also had a complete dissection of the columella skin. Epistaxis was self-limited, and an open rhinoplasty procedure was decided because the trauma occurred 1 h before admission and there was no significant edema. Surgical intervention included septal reconstruction combined with restoration of the nasal pyramid and columella. One month later, the patient had patent nasal airways, and he was satisfied with the aesthetic result. PMID:22942663

  13. High Flow Nasal Cannulae in preterm infants

    OpenAIRE

    F. Ciuffini; Colnaghi, M; A. Lavizzari; D. Mercadante; Musumeci, S; Mosca, F

    2013-01-01

    Despite of improved survival of premature infants, the incidence of long term pulmonary complications, mostly associated with ventilation-induced lung injury, remains high. Non invasive ventilation (NIV) is able to reduce the adverse effects of mechanical ventilation. Although nasal continuous positive airway pressure (NCPAP) is an effective mode of NIV, traumatic nasal complications and intolerance of the nasal interface are common. Recently high flow nasal cannula (HFNC) is emerging as an e...

  14. Nasal pulse oximetry overestimates oxygen saturation

    DEFF Research Database (Denmark)

    Rosenberg, J; Pedersen, M H

    1990-01-01

    Ten surgical patients were monitored with nasal and finger pulse oximetry (Nellcor N-200) for five study periods with alternating mouth and nasal breathing and switching of cables and sensors. Nasal pulse oximetry was found to overestimate arterial oxygen saturation by 4.7 (SD 1.4%) (bias and...

  15. Does Post Septoplasty Nasal Packing Reduce Complications?

    Directory of Open Access Journals (Sweden)

    Bijan Naghibzadeh

    2011-01-01

    Full Text Available The main issues in nasal surgery are to stabilize the nose in the good position after surgery and preserve the cartilages and bones in the favorable situation and reduce the risk of deviation recurrence. Also it is necessary to avoid the synechia formation, nasal valve narrowing, hematoma and bleeding. Due to the above mentioned problems and in order to solve and minimize them nasal packing, nasal splint and nasal mold have been advised. Patients for whom the nasal packing used may faced to some problems like naso-pulmonary reflex, intractable pain, sleep disorder, post operation infection and very dangerous complication like toxic shock syndrome. We have two groups of patients and three surgeons (one of the surgeons used post operative nasal packing in his patients and the two others surgeons did not.Complications and morbidities were compared in these two groups. Comparing the two groups showed that the rate of complication and morbidities between these two groups were same and the differences were not valuable, except the pain and discomfort post operatively and at the time of its removal. Nasal packing has several risks for the patients while its effects are not studied. Septoplasty can be safely performed without postoperative nasal packing. Nasal packing had no main findings that compensated its usage. Septal suture is one of the procedures that can be used as alternative method to nasal packing. Therefore the nasal packing after septoplasty should be reserved for the patients with increased risk of bleeding.

  16. Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    Stevens, Whitney W; Schleimer, Robert P; Kern, Robert C

    2016-01-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females, but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis, but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease. PMID:27393770

  17. Diagnostic strategies in nasal congestion

    Directory of Open Access Journals (Sweden)

    John Krouse

    2010-02-01

    Full Text Available John Krouse1, Valerie Lund2, Wytske Fokkens3, Eli O Meltzer41Temple University School of Medicine, Philadelphia, PA, USA; 2Ear Institute, University College London, UK; 3Department of Otorhinolaryngology, Amsterdam Medical Centre, Netherlands; 4Allergy and Asthma Medical Group and Research Center, San Diego, CA and Department of Pediatrics, University of California, San Diego, USAAbstract: Nasal congestion is a major symptom of upper respiratory tract disorders, and its characterization an important part of the diagnosis of these illnesses. Patient history and assessment of nasal symptoms are essential components of diagnosis, providing an initial evaluation that may be adequate to rule out serious conditions. However, current congestion medications are not always fully effective. Thus, if symptoms do not respond adequately to therapy, or symptoms suggestive of more serious conditions are present, specialized assessments may be needed. Various techniques are available for diagnosing patients, including those used chiefly by primary care clinicians and those requiring the expertise of otolaryngologists, allergists, and other specialists. Endoscopy remains a mainstay for evaluating nasal blockage and its causes, while modalities such as peak nasal inspiratory flow and acoustic rhinometry are evolving to provide easy-to-use, noninvasive procedures that are sensitive enough to measure small but clinically important abnormalities and therapeutic changes. Several imaging modalities are available to the specialist for severe or unusual cases, as are specialized diagnostic procedures that measure adjunctive features of congestion, such as impaired mucociliary function.Keywords: allergic rhinitis, congestion, diagnosis, obstruction, rhinosinusitis

  18. Nasal Schwannoma: a case report

    Directory of Open Access Journals (Sweden)

    Siu-Navarro YJ, Pérez-Carbajal AJ

    2013-10-01

    Full Text Available Introduction: Schwannomas are benign tumors that arise from Schwann cells peripheral nerves sheath. About 25-45% occur in the head and neck and only 4% of these tumors involve the sinunasal tract.Objective: To provide, through a clinic case and lecture review, the clinical and radiopatology findings of a bening and unusual tumors, as are the Nasal schwannomas. Case Report: We report a case of a young woman with nasal schwannoma, who complain of left nasal obstruction and rhinorrhea, which after subsequent imaging studies, surgical and pathology analisis, diagnosis was found. Sustained a favorable clinical evolution.Results and Discussion: The clinic and radiologic findings are nonspecific, depend upon the location or size of the tumor and subsequent involvement of surrounding structures, but generally present as a mass with less agressive behavior. The elective treatment is surgery, confirming this disease by microscopic and immunohistochemistry studies.Conclusion: Given these aspects must be considered nasal schwannomas within the differential diagnosis of a tumor with less aggressive behavior, clinical-radiological, because implies good results for the patient and unusual recurrence after surgery.

  19. Nasal cavity and frontal sinuses

    International Nuclear Information System (INIS)

    The anatomy, diagnostic principles, and surgical techniques relating to the nasal cavity and frontal sinuses are reviewed. Disorders are considered under headings of infectious, neoplastic, and miscellaneous conditions. For each disease condition, an attempt is made to emphasize particular problems and discuss new developments on treatment. Specific recommendations have been made where possible, along with the expected outcome

  20. Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

    Directory of Open Access Journals (Sweden)

    Adriana Handra-Luca

    2015-01-01

    Full Text Available Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years presented with a left nasal tumefaction. The resected specimen (1.5-cm showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.

  1. Carcinomas of the nasal cavity

    International Nuclear Information System (INIS)

    Between 1969-1985, 45 patients with carcinomas of the nasal cavity proper received curative treatment. Of these, 30 had squamous cell carcinoma, 1 un-differentiated carcinoma, 9 adenocarcinoma and 5 adenoid cystic carcinoma. 18 Patients were treated with definitive radiotherapy (interstitial brachy-therapy in 5 patients and external beam therapy in 13 patients), 27 received surgery and radiotherapy. Median length of follow-up was 11 years (range 2.8-16.8 years). 36 Patients had no evidence of disease at the last follow-up visit. All 14 patients with carcinoma of nasal septum had the disease controlled. 9/31 Patients with lesions of lateral wall and floor died of the disease, 5 of uncontrolled local disease, 2 of distant metastases, 2 of both. Disease specific survival rates at 5 and 10 years were 83 and 80%, the corresponding overall survival rates were 75 and 60%. Blindness occurred in 4 patients, 2 due to orbital exenteration and 2 to radiation injury to the cornea and optic pathway. Other infrequent side effects were bone necrosis, dental decay, nasal stenosis and septal perforation. This study indicated that prognosis of patients with nasal cavity carcinoma was better than that of patients with maxillary sinus cancer treated during the same era. In addition, the study showed that carcinoma of the nasal septum were smaller than those of lateral wall and floor at diagnosis, so that excellent control could be achieved by definitive radiotherapy; when accessible, interstitial brachytherapy might be the treatment of choice in such patients. (author). 18 refs.; 4 figs.; 2 tabs

  2. Appraisal of transverse nasal groove: A study

    Directory of Open Access Journals (Sweden)

    Belagola D Sathyanarayana

    2012-01-01

    Full Text Available Background: Transverse nasal groove is a condition of cosmetic concern which awaits due recognition and has been widely described as a shallow groove that extends transversely over the dorsum of nose. However, we observed variations in the clinical presentations of this entity, hitherto undescribed in literature. Aims: We conducted a clinicoepidemiological study of transverse nasal lesions in patients attending our outpatient department. Methods: We conducted a prospective observational study. We screened all patients attending our out-patient department for presence of transverse nasal lesions, signs of any dermatosis and associated other skin conditions. Results: One hundred patients were recruited in the study. Females (80% predominated over males. Most patients were of 15-45 years age group (70%. Majority of the transverse nasal lesions were classical transverse nasal groove (39% and others included transverse nasal line (28%, strip (28%, ridge (4% and loop (1%. Seborrhoeic diathesis was the most common condition associated with transverse nasal lesion. Conclusions: Occurrence of transverse nasal line, strip, ridge and loop, in addition to classical transverse nasal groove implies that latter is actually a subset of transverse nasal lesions. Common association of this entity with seborrheic dermatitis, seborrhea and dandruff raises a possibility of whether transverse nasal lesion is a manifestation of seborrheic diathesis.

  3. Drag on Sessile Drops

    Science.gov (United States)

    Milne, Andrew J. B.; Fleck, Brian; Nobes, David; Sen, Debjyoti; Amirfazli, Alidad; University of Alberta Mechanical Engineering Collaboration

    2013-11-01

    We present the first ever direct measurements of the coefficient of drag on sessile drops at Reynolds numbers from the creeping flow regime up to the point of incipient motion, made using a newly developed floating element differential drag sensor. Surfaces of different wettabilities (PMMA, Teflon, and a superhydrophobic surface (SHS)), wet by water, hexadecane, and various silicone oils, are used to study the effects of drop shape, and fluid properties on drag. The relation between drag coefficient and Reynolds number (scaled by drop height) varies slightly with liquid-solid system and drop volume with results suggesting the drop experiences increased drag compared to similar shaped solid bodies due to drop oscillation influencing the otherwise laminar flow. Drops adopting more spherical shapes are seen to experience the greatest force at any given airspeed. This indicates that the relative exposed areas of drops is an important consideration in terms of force, with implications for the shedding of drops in applications such as airfoil icing and fuel cell flooding. The measurement technique used in this work can be adapted to measure drag force on other deformable, lightly adhered objects such as dust, sand, snow, vesicles, foams, and biofilms. The authours acknowledge NSERC, Alberta Innovates Technology Futures, and the Killam Trusts.

  4. Bubble and drop interfaces

    CERN Document Server

    Miller

    2011-01-01

    The book aims at describing the most important experimental methods for characterizing liquid interfaces, such as drop profile analysis, bubble pressure and drop volume tensiometry, capillary pressure technique, and oscillating drops and bubbles. Besides the details of experimental set ups, also the underlying theoretical basis is presented in detail. In addition, a number of applications based on drops and bubbles is discussed, such as rising bubbles and the very complex process of flotation. Also wetting, characterized by the dynamics of advancing contact angles is discussed critically. Spec

  5. Effect of nasal decongestion on voice spectrum of a nasal consonant-vowel.

    Science.gov (United States)

    Lee, Guo-She; Yang, Cheryl C H; Wang, Ching-Ping; Kuo, Terry B J

    2005-03-01

    The nasal cavity and its related structures make significant contributions to human phonation, especially the resonance of voice spectra. The voice spectra of the nasal consonant-vowel (CV), [md:], in the subjects with nasal obstruction were obtained and were compared with the spectra of the same CV vocalized by the same subjects after topical nasal decongestion treatment with 1:1000 epinephrine solution. Results revealed that the intensity damping was more marked in the high-frequency area (>1600 Hz) after the nasal decongestion. Moreover, the intensities of the spectral valleys damped more than the spectral peaks, especially the spectral valley of 1000-2700 Hz. Therefore, a more complex spectral pattern was formed by the resultant uneven damping effect after nasal decongestion. The nasal cavity plays an important role in the formation of spectral peaks and valleys, and such engraved voice spectra may also characterize nasal voices like the nasal CV [md:] demonstrated in our study. PMID:15766851

  6. Primary Nasal Reconstruction in Self-Inflicted Nasal Injury.

    Science.gov (United States)

    Kapadia, Abizer; John, Jerry R; Gaba, Sunil; Sharma, Ramesh Kumar

    2015-10-01

    Self-inflicted injury of the nose is extremely rare. It may be associated with severe psychopathology and suicidal ideation. The authors report a case of a 24-year-old man, who presented with soft-tissue loss over both the alae of his nose. He had cut off the alar rims with an ordinary razor blade. He was overtly concerned about his nose being excessively broad and fat. A diagnosis of body dysmorphic disorder with nonsuicidal self-injury was made. Patient was observed during 72 hours in hospital with psychiatric support and local dressings. The authors undertook primary nasal reconstruction with nasolabial flaps on both sides for coverage. In conclusion, self-inflicted nasal injury mandates a judicious balancing of psychiatric support and surgical reconstruction. This can prevent untoward sequelae including further self-harm and suicide. PMID:26468831

  7. Paramagnetic Leidenfrost Drops

    CERN Document Server

    Piroird, Keyvan; Clanet, Christophe; Quéré, David

    2010-01-01

    We present a fluid dynamics video showing the behavior of drops of liquid oxygen, at room temperature. Due to their low boiling point, these drops levitate on a cushion of their own vapour. This property gives them a high mobility, as known more generally in such Leidenfrost situations. But liquid oxygen is also paramagnetic, and thus likely to be manipulated using a magnet. It is first shown that the shape of the drop can be modified by changing the drop/magnet distance; approaching the magnet acts as reinforcing gravity, so that the drops get flattened by this action. The transformation is of course reversible: as the magnet is withdrawn, the liquid recovers its quasi-spherical shape. Magnets can also be used to trap the oxygen drops. As they pass above a magnet, they slow down significantly, a consequence of their deformation: despite a very low friction, the vibrations induced by the drop deformations represent an important source of dissipation: below a well-defined velocity, drops can even be stopped in...

  8. Contrastive and contextual vowel nasalization in Ottawa

    Science.gov (United States)

    Klopfenstein, Marie

    2005-09-01

    Ottawa is a Central Algonquian language that possesses the recent innovation of contrastive vowel nasalization. Most phonetic studies done to date on contrastive vowel nasalization have investigated Indo-European languages; therefore, a study of Ottawa could prove to be a valuable addition to the literature. To this end, a percentage of nasalization (nasal airflow/oral + nasal airflow) was measured during target vowels produced by native Ottawa speakers using a Nasometer 6200-3. Nasalized vowels in the target word set were either contrastively or contextually nasalized: candidates for contextual nasalization were either regressive or perserverative in word-initial and word-final syllables. Subjects were asked to read words containing target vowels in a carrier sentence. Mean, minimum, and maximum nasalance were obtained for each target vowel across its full duration. Target vowels were compared across context (regressive or perseverative and word-initial or word-final). In addition, contexts were compared to determine whether a significant difference existed between contrastive and contextual nasalization. Results for Ottawa will be compared with results for vowels in similar contexts in other languages including Hindi, Breton, Bengali, and French.

  9. Effect of Nasal Obstruction on Continuous Positive Airway Pressure Treatment: Computational Fluid Dynamics Analyses.

    Directory of Open Access Journals (Sweden)

    Tadashi Wakayama

    Full Text Available Nasal obstruction is a common problem in continuous positive airway pressure (CPAP therapy for obstructive sleep apnea and limits treatment compliance. The purpose of this study is to model the effects of nasal obstruction on airflow parameters under CPAP using computational fluid dynamics (CFD, and to clarify quantitatively the relation between airflow velocity and pressure loss coefficient in subjects with and without nasal obstruction.We conducted an observational cross-sectional study of 16 Japanese adult subjects, of whom 9 had nasal obstruction and 7 did not (control group. Three-dimensional reconstructed models of the nasal cavity and nasopharynx with a CPAP mask fitted to the nostrils were created from each subject's CT scans. The digital models were meshed with tetrahedral cells and stereolithography formats were created. CPAP airflow simulations were conducted using CFD software. Airflow streamlines and velocity contours in the nasal cavities and nasopharynx were compared between groups. Simulation models were confirmed to agree with actual measurements of nasal flow rate and with pressure and flow rate in the CPAP machine.Under 10 cmH2O CPAP, average maximum airflow velocity during inspiration was 17.6 ± 5.6 m/s in the nasal obstruction group but only 11.8 ± 1.4 m/s in the control group. The average pressure drop in the nasopharynx relative to inlet static pressure was 2.44 ± 1.41 cmH2O in the nasal obstruction group but only 1.17 ± 0.29 cmH2O in the control group. The nasal obstruction and control groups were clearly separated by a velocity threshold of 13.5 m/s, and pressure loss coefficient threshold of approximately 10.0. In contrast, there was no significant difference in expiratory pressure in the nasopharynx between the groups.This is the first CFD analysis of the effect of nasal obstruction on CPAP treatment. A strong correlation between the inspiratory pressure loss coefficient and maximum airflow velocity was found.

  10. Effect of Nasal Obstruction on Continuous Positive Airway Pressure Treatment: Computational Fluid Dynamics Analyses

    Science.gov (United States)

    Wakayama, Tadashi; Suzuki, Masaaki; Tanuma, Tadashi

    2016-01-01

    Objective Nasal obstruction is a common problem in continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea and limits treatment compliance. The purpose of this study is to model the effects of nasal obstruction on airflow parameters under CPAP using computational fluid dynamics (CFD), and to clarify quantitatively the relation between airflow velocity and pressure loss coefficient in subjects with and without nasal obstruction. Methods We conducted an observational cross-sectional study of 16 Japanese adult subjects, of whom 9 had nasal obstruction and 7 did not (control group). Three-dimensional reconstructed models of the nasal cavity and nasopharynx with a CPAP mask fitted to the nostrils were created from each subject’s CT scans. The digital models were meshed with tetrahedral cells and stereolithography formats were created. CPAP airflow simulations were conducted using CFD software. Airflow streamlines and velocity contours in the nasal cavities and nasopharynx were compared between groups. Simulation models were confirmed to agree with actual measurements of nasal flow rate and with pressure and flow rate in the CPAP machine. Results Under 10 cmH2O CPAP, average maximum airflow velocity during inspiration was 17.6 ± 5.6 m/s in the nasal obstruction group but only 11.8 ± 1.4 m/s in the control group. The average pressure drop in the nasopharynx relative to inlet static pressure was 2.44 ± 1.41 cmH2O in the nasal obstruction group but only 1.17 ± 0.29 cmH2O in the control group. The nasal obstruction and control groups were clearly separated by a velocity threshold of 13.5 m/s, and pressure loss coefficient threshold of approximately 10.0. In contrast, there was no significant difference in expiratory pressure in the nasopharynx between the groups. Conclusion This is the first CFD analysis of the effect of nasal obstruction on CPAP treatment. A strong correlation between the inspiratory pressure loss coefficient and maximum airflow

  11. Nasal airway responses to nasal continuous positive airway pressure breathing: An in-vivo pilot study.

    Science.gov (United States)

    White, David E; Bartley, Jim; Shakeel, Muhammad; Nates, Roy J; Hankin, Robin K S

    2016-06-14

    The nasal cycle, through variation in nasal airflow partitioning, allows the upper airway to accommodate the contrasting demands of air conditioning and removal of entrapped air contaminants. The purpose of this study was to investigate the influence of nasal continuous positive airway pressure (nCPAP) breathing has on both nasal airflow partitioning and nasal geometry. Using a custom-made nasal mask, twenty healthy participants had the airflow in each naris measured during normal nasal breathing followed by nCPAP breathing. Eight participants also underwent magnetic resonance imaging (MRI) of the nasal region during spontaneous nasal breathing, and then nCPAP breathing over a range of air pressures. During nCPAP breathing, a simultaneous reduction in airflow through the patent airway together with a corresponding increase in airway flow within the congested nasal airway were observed in sixteen of the twenty participants. Nasal airflow resistance is inversely proportional to airway cross-sectional area. MRI data analysis during nCPAP breathing confirmed airway cross-sectional area reduced along the patent airway while the congested airway experienced an increase in this parameter. During awake breathing, nCPAP disturbs the normal inter-nasal airflow partitioning. This could partially explain the adverse nasal drying symptoms frequently reported by many users of this therapy. PMID:27173595

  12. Nasal leech infestation causing persistent epistaxis

    OpenAIRE

    Sarathi, Kalra

    2011-01-01

    Foreign bodies in the nasal cavity are commonly encountered as a cause of epistaxis; however, nasal leech infestation as a cause of unilateral persistent epistaxis is very rare. Examination of nasal cavity revealed fleshy material in the left nostril, which was identified as leech. The leech was removed with the help of an artery forceps following irrigation of the left nostril with normal saline and adopting wait-and-watch policy. In developing countries, leech infestation as a cause of epis...

  13. Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.

    OpenAIRE

    Rajakulasingam, K.; Polosa, R; Lau, L.C.; Church, M. K.; Holgate, S T; Howarth, P. H.

    1993-01-01

    BACKGROUND--Bradykinin may contribute to the pathogenesis of allergic rhinitis. Like histamine, nasal challenge with bradykinin induces rhinorrhoea, nasal blockage, and plasma protein leakage. Their comparative nasal potencies have not, however, been fully elucidated. METHODS--Three double blind, randomised, placebo controlled and cross-over studies were undertaken to compare objectively the nasal effects of bradykinin, histamine, and vehicle. RESULTS--Both bradykinin and histamine produced d...

  14. [Review: pathophysiology and methodology of nasal packing].

    Science.gov (United States)

    Beule, A G; Weber, R K; Kaftan, H; Hosemann, W

    2004-08-01

    Nasal packing is a frequent procedure to control spontaneous nasal bleeding or postoperative oozing following different types of nasal surgery. It strives for internal stabilization of the nasal framework and for optimizing wound healing by prevention of stenosis or synechia. A lot of different materials is used and there is no accepted standard concerning the type and application. A review on pathophysiology of the packed nose is given together with a survey on customary packing materials focussing on the specific merits, demerits and side-effects including economical aspects. PMID:15316896

  15. Nasal and Oral Consonant Similarity in Speech Errors: Exploring Parallels with Nasal Consonant Harmony

    Science.gov (United States)

    Walker, Rachel

    2007-01-01

    Previous research has found that "similar" sounds interact in phonological nasal consonant harmony, wherein certain consonants become nasals when the word contains a nasal (e.g., Kikongo: /-kun-idi/ [right arrow] [-kun-ini] "planted"). Across languages, stops and approximants are chiefly affected, especially voiced consonants and ones that match…

  16. Lambda-dropping

    DEFF Research Database (Denmark)

    Danvy, Olivier; Schultz, Ulrik Pagh

    Lambda-lifting a functional program transforms it into a set of recursive equations. We present the symmetric transformation: lambda-dropping. Lambda-dropping a set of recursive equations restores block structure and lexical scope.For lack of scope, recursive equations must carry around all the...... parameters that any of their callees might possibly need. Both lambda-lifting and lambda-dropping thus require one to compute a transitive closure over the call graph:• for lambda-lifting: to establish the Def/Use path of each free variable (these free variables are then added as parameters to each of...... the functions in the call path);• for lambda-dropping: to establish the Def/Use path of each parameter (parameters whose use occurs in the same scope as their definition do not need to be passed along in the call path).Without free variables, a program is scope-insensitive. Its blocks are then...

  17. Drop Tower Workshop

    Science.gov (United States)

    Urban, David

    2013-01-01

    Ground based microgravity facilities are an important proving ground for space experiments, ground-based research and space hardware risk mitigation. An overview of existing platforms will be discussed with an emphasis on drop tower capabilities. The potential for extension to partial gravity conditions will be discussed. Input will be solicited from attendees for their potential to use drop towers in the future and the need for enhanced capabilities (e.g. partial gravity)

  18. Neurilemmoma of lateral nasal wall

    Directory of Open Access Journals (Sweden)

    Jyotsna Naresh Bharti

    2015-06-01

    Full Text Available Neurilemmoma is a benign tumour of nerve sheath origin that can arise from myelinated nerve. The Head and neck is the most frequent site involved and other sites are scalp, face, oral cavity, pharynx, larynx, trachea and ear. Neurilemmoma usually occur as solitary lesions and in association with NF type 2. Malignant transformation is very rare. We report a case of 18 year old male presented with complaint of nasal obstruction and swelling in right side of nose. We discuss the clinical presentation, histologic features, and therapeutic options for such a rare benign lesion.

  19. Effect of the nasal cycle on congestive response during bilateral nasal allergen provocation

    Directory of Open Access Journals (Sweden)

    Tomasz Gotlib

    2014-06-01

    Full Text Available Background. Bilateral nasal allergen provocation usually produces more pronounced obstruction of one nasal passage. It was found that this could be related to the stage of the nasal cycle before the provocation. objective. To discover whether the stage of the nasal cycle is decisive for asymmetry in congestive response observed during bilateral allergen nasal provocation. methods. Two bilateral nasal allergen provocations were performed in a group of 26 pollen-sensitive volunteers. Acoustic rhinometry measurements were taken during the nasal cycle, and then after the provocation. A cross-sectional area at the level of the inferior turbinate (CSA-2 was measured. Consecutive challenges were performed in the opposite phase of the nasal cycle: the side which had been wide just before the first challenge, was narrow before the second provocation. results. Asymmetry in CSA-2 reduction between the nasal passages was observed in most cases. Significant difference was observed between mean CSA-2 reduction rate (reactivity of the side that responded with greater congestion, and the opposite side. No significant difference was found in mean CSA-2 reduction rate between the side which was narrow, and the side which was wide before provocation. conclusions. Asymmetry of congestive response during bilateral nasal allergen provocation is not dependent on the stage of the nasal cycle preceding the challenge.

  20. ANTHROPOMETRIC STUDY OF NASAL INDEX OF EGYPTIANS

    Directory of Open Access Journals (Sweden)

    Abdelmonem Awad Hegazy

    2014-12-01

    Full Text Available Background: The nasal index determination is one of the most commonly used anthropometric parameters in classifying human races. There are few reports in medical literature concerning nasal index that specifically address particular Egyptian populations. The objective of this study was to determine the normal parameters of external nose (width, height and nasal index in Egyptians. Methods: The study was conducted randomly on healthy Egyptian subjects of both sexes. Nasal height and width were measured using vernier caliper. Then, nasal index was determined for each subject. The obtained data were subjected to statistical analysis. Results: A total of 290 subjects, 144 males and 146 females, aged 1 month– 65 years, were enrolled in the study. The study showed the existence of sexual dimorphism in nasal morphology, appearing after the age 20 years. The mean nasal index in the investigated adults was 68.01; in males and females was 71.46 and 64.56, respectively. Conclusions: The dominant nasal type in Egyptians was in-between mesorrhine "medium" and leptorrhine "narrow" nose. Forensic and anthropological research, as well as cosmetic and reconstructive surgery may benefit from age- and sex- based data of the study.

  1. Nasal mucociliary clearance in coal mine workers

    Energy Technology Data Exchange (ETDEWEB)

    Cinar, F.; Beder, L. [Karaelmas University, Kozlu Zonguldak (Turkey)

    2004-06-01

    The purpose of this study was to analyze the effect of coal dust particles on nasal mucociliary function in coal mine workers. Using the saccharin method, nasal mucociliary clearance was determined for 77 subjects, of which 39 who worked in a coal mine were actively exposed to coal dust whereas 38 were unexposed control subjects. The measurements were performed in the coal mine, at the level of 170 m below sea level. The average saccharin nasal transit time in coal mine workers, 12.61 (SD: 4.30) minutes, is longer, than that of the control subjects, 10.97 (SD: 3.22). Although the findings of this study demonstrate that the coal particles affect the nasal mucociliary clearance, the difference in saccharin nasal transit time between the two groups (exposed vs unexposed) is not statistically significant (P = 0.063).

  2. Impact of granular drops

    KAUST Repository

    Marston, J. O.

    2013-07-15

    We investigate the spreading and splashing of granular drops during impact with a solid target. The granular drops are formed from roughly spherical balls of sand mixed with water, which is used as a binder to hold the ball together during free-fall. We measure the instantaneous spread diameter for different impact speeds and find that the normalized spread diameter d/D grows as (tV/D)1/2. The speeds of the grains ejected during the “splash” are measured and they rarely exceed twice that of the impact speed.

  3. Coalescence of sessile drops

    CERN Document Server

    Nikolayev, Vadim; Pomeau, Yves; Andrieu, Claire

    2016-01-01

    We present an experimental and theoretical description of the kinetics of coalescence of two water drops on a plane solid surface. The case of partial wetting is considered. The drops are in an atmosphere of nitrogen saturated with water where they grow by condensation and eventually touch each other and coalesce. A new convex composite drop is rapidly formed that then exponentially and slowly relaxes to an equilibrium hemispherical cap. The characteristic relaxation time is proportional to the drop radius R * at final equilibrium. This relaxation time appears to be nearly 10 7 times larger than the bulk capillary relaxation time t b = R * $\\eta$/$\\sigma$, where $\\sigma$ is the gas--liquid surface tension and $\\eta$ is the liquid shear viscosity. In order to explain this extremely large relaxation time, we consider a model that involves an Arrhenius kinetic factor resulting from a liquid--vapour phase change in the vicinity of the contact line. The model results in a large relaxation time of order t b exp(L/R...

  4. Rod drop measurement analysis

    International Nuclear Information System (INIS)

    In some cases control rod worth efficiencies evaluated by inverse point kinetics from out-core detector currents remarkable differ from direct calculations. Explanation of this effects is given and is supported by the analysis of some WWER-440 rod drop experiments. (Authors)

  5. Three-dimensional Evaluation of Nasal Surgery in Patients with Obstructive Sleep Apnea

    Institute of Scientific and Technical Information of China (English)

    Dan-Mo Cui; De-Min Han; Busaba Nicolas; Chang-Long Hu; Jun Wu; Min-Min Su

    2016-01-01

    Background:Obstructive sleep apnea (OSA) is a common sleep disorder and is characterized by airway collapse at multiple levels of upper airway.The effectiveness of nasal surgery has been discussed in several studies and shows a promising growing interest.In this study,we intended to evaluate the effects of nasal surgery on the upper airway dimensions in patients with OSA using three-dimensional (3D)reconstruction of cone-beam computed tomography (CT).Methods:Twelve patients with moderate to severe OSA who underwent nasal surgery were included in this study.All patients were diagnosed with OSA using polysomnography (PSG) in multi sleep health centers associated with Massachusetts General Hospital,Massachusetts Eye and Ear Infirmary and the Partners Health Care from May 31,2011 to December 14,2013.The effect of nasal surgery was evaluated by the examination of PSG,subjective complains,and 3D reconstructed CT scan.Cross-sectional area was measured in eleven coronal levels,and nasal cavity volume was evaluated from anterior nasal spine to posterior nasal spine.The thickness of soft tissue in oral pharynx region was also measured.Results:Five out of the 12 patients were successfully treated by nasal surgery,with more than 50% drop of apnea-hypopnea index.All the 12 patients showed significant increase of cross-sectional area and volume postoperatively.The thickness of soft tissue in oral pharynx region revealed significant decrease postoperatively,which decreased from 19.14 ± 2.40 cm2 and 6.11 ± 1.76 cm2 to 17.13 ± 1.91 cm2 and 5.22 ± 1.20 cm2.Conclusions:Nasal surgery improved OSA severity as measured by PSG,subjective complaints,and 3D reconstructed CT scan.3D assessment of upper airway can play an important role in the evaluation of treatment outcome.

  6. Nasal Septal Deviation and Facial Skeletal Asymmetries.

    Science.gov (United States)

    Hartman, Christopher; Holton, Nathan; Miller, Steven; Yokley, Todd; Marshall, Steven; Srinivasan, Sreedevi; Southard, Thomas

    2016-03-01

    During ontogeny, the nasal septum exerts a morphogenetic influence on the surrounding facial skeleton. While the influence of the septum is well established in long snouted animal models, its role in human facial growth is less clear. If the septum is a facial growth center in humans, we would predict that deviated septal growth would be associated with facial skeletal asymmetries. Using computed tomographic (CT) scans of n = 55 adult subjects, the purpose of this study was to test whether there is a correlation between septal deviation and facial asymmetries using three-dimensional (3D) geometric morphometric techniques. We calculated deviation as a percentage of septal volume relative to the volume of a modeled non-deviated septum. We then recorded skeletal landmarks representing the nasal, palatal, and lateral facial regions. Landmark data were superimposed using Procrustes analysis. First, we examined the correlation between nasal septal deviation and the overall magnitude of asymmetry. Next, we assessed whether there was a relationship between nasal septal deviation and more localized aspects of asymmetry using multivariate regression analysis. Our results indicate that while there was no correlation between septal deviation and the overall magnitude of asymmetry, septal deviation was associated with asymmetry primarily in the nasal floor and the palatal region. Septal deviation was unassociated with asymmetries in the lateral facial skeleton. Though we did not test the causal relationship between nasal septal deviation and facial asymmetry, our results suggest that the nasal septum may have an influence on patterns of adult facial form. PMID:26677010

  7. Canine and feline nasal neoplasia.

    Science.gov (United States)

    Malinowski, Christine

    2006-05-01

    Dogs and cats of our society have outgrown their status as merely pets and are now considered our close companions and even family members. This shift in their roles has led to pet owners seeking improved preventative medicine for their four-legged friends. Subsequently, dogs and cats are living longer lives than ever before and developing more old-age-related diseases. One of the most devastating diseases of older animals is cancer. Once a veterinarian has detected cancer in a pet, pet owners seek advice on their next course of action. This article is intended to provide concise information regarding the diagnosis and treatment of intranasal tumors of the dog and cat. This article outlines the forms of nasal tumors that are the most common, the recommended imaging and biopsy techniques to diagnose the tumor, and the most appropriate treatments of them. PMID:16711615

  8. Sonographic evaluation of nasal bone fractures

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Eun; Lee, Sun Wha; Lee, Jung Kyoung; Chung, Sun Hee [College of Medicine, Ewha Womans University, Seoul (Korea, Republic of)

    2000-07-01

    To describe the sonographic findings of nasal bone fracture and evaluate the diagnostic value of sonography (US). Thirty-six patients with sustained nasal trauma underwent plain radiography, US and CT, and the CT findings were used as the gold standard. The sonographic findings were retrospectively reviewed and compared with those of radiography and CT. Twelve patients underwent follow-up US within 3 months of reduction. Sonographic findings of nasal bone fractures were irregularity (n=3D7), discontinuity (n=3D25) and displacement with discontinuity (n=3D28) of the thin smooth echogenic line formed by the ventral cortex of the nasal bone. Sixty-five nasal bone fractures (36 patients) were identified by CT, 60 of these were revealed on US but only 41 by plain radiographs. CT demonstrated unilateral involvement of nasal bone fractures in seven bones and bilateral involvement in 58, while US revealed unilateral involvement in 12 and bilateral involvement in 48. Plain radiographs, unilateral involvement in 21 bones and bilateral fractures in 20. Plain radiographs were more limited in detecting the location of nasal bone fractures than was US. On follow-up US in 12 patients, normal alignment without residual abnormality was observed in seven patients, residual cortical irregularities in four, and minimal cortical depression in one. The sonographic findings of nasal bone fractures were similar to those of CT in detecting the location and degree of depression or displacement of nasal bone fractures. We believe that US is very useful for the evaluation of such fractures, especially in cases in which plain radiographs reveal equivocal abnormality, or postreduction status is uncertain. (author)

  9. Nasal Bone Osteotomies with Nonpowered Tools.

    Science.gov (United States)

    Gruber, Ronald P; Garza, Rebecca M; Cho, Gerald J

    2016-01-01

    Controlling the shape of the nasal bones has long been a frustrating problem. Conventional osteotomies are associated with bleeding, loss of reduction, inability to achieve the desired alignment, improperly placed osteotomy sites, and spicule formation. A nonpowered osteotomy method empirically provided the safest and most controlled technique to achieve the desired anatomic result. The nasal bones should be thought of as 2 thin nasal plates that can be released from their medial and lateral attachments to become mobile units that can affect the dorsal width and bony base independently. There is a learning curve to osteotomies. PMID:26616696

  10. Nose and Nasal Planum Neoplasia, Reconstruction.

    Science.gov (United States)

    Worley, Deanna R

    2016-07-01

    Most intranasal lesions are best treated with radiation therapy. Computed tomographic imaging with intravenous contrast is critical for treatment planning. Computed tomographic images of the nose will best assess the integrity of the cribriform plate for central nervous system invasion by a nasal tumor. Because of an owner's emotional response to an altered appearance of their dog's face, discussions need to include the entire family before proceeding with nasal planectomy or radical planectomy. With careful case selection, nasal planectomy and radical planectomy surgeries can be locally curative. PMID:26968300

  11. Model demonstrates functional purpose of the nasal cycle

    OpenAIRE

    White, David E.; Bartley, Jim; Nates, Roy J

    2015-01-01

    Background Despite the occurrence of the nasal cycle being well documented, the functional purpose of this phenomenon is not well understood. This investigation seeks to better understand the physiological objective of the nasal cycle in terms of airway health through the use of a computational nasal air-conditioning model. Method A new state-variable heat and water mass transfer model is developed to predict airway surface liquid (ASL) hydration status within each nasal airway. Nasal geometr...

  12. Plastinated nasal model: a new concept of anatomically realistic cast.

    OpenAIRE

    Durand, Marc; Pourchez, Jérémie; Louis, Bruno; Pouget, Jean-François; Isabey, Daniel; Coste, André; Prades, Jean-Michel; Rusch, Philippe; Cottier, Michèle

    2011-01-01

    BACKGROUND: For many years, researchers have been interested in investigating airflow and aerosol deposition in the nasal cavities. The nasal airways appear to be a complex geometrical system. Thus, in vitro experimental studies are frequently conducted with a more or less biomimetic nasal replica. AIM: This study is devoted to the development of an anatomically realistic nose model with bilateral nasal cavities, i.e. nasal anatomy, airway geometry and aerodynamic properties as close as possi...

  13. Coalescence of Liquid Drops

    CERN Document Server

    Eggers, J; Stone, H A; Eggers, Jens; Lister, John R.; Stone, Howard A.

    1999-01-01

    When two drops of radius $R$ touch, surface tension drives an initially singular motion which joins them into a bigger drop with smaller surface area. This motion is always viscously dominated at early times. We focus on the early-time behavior of the radius $\\rmn$ of the small bridge between the two drops. The flow is driven by a highly curved meniscus of length $2\\pi \\rmn$ and width $\\Delta\\ll\\rmn$ around the bridge, from which we conclude that the leading-order problem is asymptotically equivalent to its two-dimensional counterpart. An exact two-dimensional solution for the case of inviscid surroundings [Hopper, J. Fluid Mech. ${\\bf 213}$, 349 (1990)] shows that R)]$; and thus the same is true in three dimensions. The case of coalescence with an external viscous fluid is also studied in detail both analytically and numerically. A significantly different structure is found in which the outer fluid forms a toroidal bubble of radius $\\Delta \\propto \\rmn^{3/2}$ at the meniscus and $\\rmn \\sim (t\\gamma/4\\pi\\eta)...

  14. NASAL cytology: practical aspects and clinical relevance.

    Science.gov (United States)

    Gelardi, M; Iannuzzi, L; Quaranta, N; Landi, M; Passalacqua, G

    2016-06-01

    Nasal cytology is a simple and safe diagnostic procedure that allows to assess the normal and pathological aspects of the nasal mucosa, by identifying and counting the cell types and their morphology. It can be easily performed by a nasal scraping followed by May-Grunwald-Giemsa staining and optical microscopy reading. This procedure allows to identify the normal cells (ciliated and mucinous), the inflammatory cells (lymphocytes, neutrophils, eosinophils, mast cells), bacteria, or fungal hyphae/spores. Apart from the normal cell population, some specific cytological patterns can be of help in discriminating among various diseases. Viral infections, allergic rhinitis, vasomotor rhinitis and overlapping forms can be easily identified. According to the predominant cell type, various entities can be defined (named as NARES, NARESMA, NARMA). This implies a more detailed knowledge and assessment of the disease that can integrate the standard diagnostic procedures. Nasal cytology also represents a useful research tool for diagnosis and therapy. PMID:27009397

  15. Nasal Chondromesenchymal Hamartoma in a Child

    International Nuclear Information System (INIS)

    Nasal chondromesenchymal hamartoma (NCMH) is a benign tumor that was described in 1998. The occurrence of this lesion in the nasal cavity of infants and children is especially rare, with only 21 cases reported in the international literature. We report a 12-month-old boy with respiratory distress due to nasal obstruction. Computed tomographic scan and magnetic resonance imaging examination demonstrated a soft-tissue mass obstructing the left nasal cavity. Digital subtraction angiography and preoperative superselective embolization with microparticles were also performed. The tumor was completely resected surgically. Histopathology and immunohistochemical analyses of the tumor disclosed a NCMH. The imaging characteristics of the tumor are described and the radiology literature is reviewed.

  16. Nasal septal teratoma in a child

    Directory of Open Access Journals (Sweden)

    Akinyemi Oluwole A

    2007-05-01

    Full Text Available Abstract Background Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells. Head and neck teratomas constitute about 10% of all cases. Only two cases of mature teratoma of the nasal septum have previously been documented in the world literature. Case presentation We present a case of histologically confirmed mature teratoma arising from the nasal septum in an eighteen month old Nigerian female who presented with a history of noisy breathing associated with recurrent rhinorrhea since birth. Physical examination revealed obstruction of the right nasal cavity by a pale fleshy mass. She underwent a total surgical excision and to date, after thirty one months follow-up, she is free from recurrence. Conclusion The prognosis for benign teratoma of the nasal septum is good following total surgical excision.

  17. Discriminating between Nasal and Mouth Breathing

    OpenAIRE

    Curran, Kevin; Yuan, Peng; Coyle, Damian

    2010-01-01

    The recommendation to change breathing patterns from the mouth to the nose can have a significantly positive impact upon the general well being of the individual. We classify nasal and mouth breathing by using an acoustic sensor and intelligent signal processing techniques. The overall purpose is to investigate the possibility of identifying the differences in patterns between nasal and mouth breathing in order to integrate this information into a decision support system which will form the b...

  18. Nasal septal teratoma in a child

    OpenAIRE

    Akinyemi Oluwole A; Ngwu Bethrand A; Kokong Daniel D; Ibekwe Titus S; Nwaorgu Onyekwere G; Akang Effiong E

    2007-01-01

    Abstract Background Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells. Head and neck teratomas constitute about 10% of all cases. Only two cases of mature teratoma of the nasal septum have previously been documented in the world literature. Case presentation We present a case of histologically confirmed mature teratoma arising from the nasal septum in an eighteen month old Nigerian female who presented with a history of noisy breathing associated with r...

  19. Eosinophilic Angiocentric Fibrosis of the Nasal Septum

    Directory of Open Access Journals (Sweden)

    Yunchuan Li

    2013-01-01

    Full Text Available Background. Eosinophilic angiocentric fibrosis (EAF is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with a slow growing mass at her anterior nasal septum for over eight years. She complained of persistent nasal obstruction, epistaxis, sometimes diffused facial pain, and chronic headache. 3 years ago, the tumor was partially resected for ventilation and a nasal septum perforation was left. Imaging findings indicated soft-tissue thickening of the anterior part of septum and adjacent lateral nasal walls. Pathological examination showed numerous inflammatory cells infiltrates containing eosinophils, fibroinflammatory lesion with a whorled appearance fibrosis which typically surrounded vessels. A diagnosis of eosinophilic angiocentric fibrosis was made. All laboratory tests were unremarkable. Skin prick test was positive. The tumor-like lesion was totally resected. Conclusions. EAF is a rare benign and progressive disorder causing destruction. Combined with radiological imaging of EAF historical findings contribute to the diagnosis. It is important to prevent tumor from recurrence by total resection of the lesion.

  20. Spindle cell carcinoma of the nasal cavity

    Directory of Open Access Journals (Sweden)

    Mark D DeLacure

    2013-02-01

    Full Text Available Spindle cell carcinoma (SpCC is a unique variant of squamous cell carcinoma (SCC. SpCC confined to the nasal cavity is extremely rare, with only one case having been previously reported. We present a case report of nasal cavity SpCC and review the literature on this rare entity. A 29-year-old male presented with intermittent epistaxis from the left nasal cavity. On physical examination, the patient had an ulcerated mass in the left nasal vestibule and a biopsy showed a proliferation of spindle and epitheliod cells. The patient underwent wide local excision of the mass via a lateral alotomy approach and reconstruction with a composite conchal bowl skin and cartilage graft. Histologically, the mass had dyplastic squamous epithelium and spindle-shaped cells admixed with epitheliod cells. Immunohistochemistry was only positive for pancytokeratin AE1/AE3 and vimentin. Six months after surgery, the patient continues to have no evidence of disease. On literature review, only one previous case of SpCC confined to the nasal cavity was identified. We present a rare case of nasal cavity SpCC. No definite treatment protocol exists for this unique entity, but we believe that this tumor should primarily be treated with aggressive, wide local excision. Adjuvant radiation and/or chemotherapy have also been used anecdotally.

  1. CT findings of malignant nasal cavity tumors

    International Nuclear Information System (INIS)

    To evaluate the CT findings of malignant nasal cavity tumors. Retrospective analysis was performed on 20 patients with pathologically-proven malignant nasal cavity tumors. Using CT, we analysed their location, extent of bone destruction and of involvement of adjacent structures, and enhancing pattern. A total of 20 cases included nine squamous cell carcinomas, three olfactory neuroblastomas, three lymphomas, two polymorphic reticulosis, one adenoid cystic carcinoma, one undifferentiated carcinoma and one metastasis from renal cell carcinoma. All cases except one adenoid cystic carcinoma and one squamous cell carcinoma revealed bone destruction or erosion. Aggressive bone destruction and irregular enhancement were seen in eight cases of squamous cell carcinoma, seven cases of which showed involvement of the adjacent paranasal sinuses, nasopharynx, and orbit. Olfactory neuroblastomas were centered in the superior nasal cavity and the adjacent ethmoid sinus, and erosion or destruction of the cribriform plate had occurred. Lymphomas showed bilateral involvement, with uniform contrast enhancement. Polymorphic reticuloses showed perforation or erosion of the nasal septum, with bilateral involvement of the nasal cavity. The location, presence of bone destruction, involvement of adjacent structures, and enhancement pattern of tumor on CT can be helpful for the differential diagnosis of malignant nasal cavity tumors

  2. Nasal continuous positive airway pressure

    DEFF Research Database (Denmark)

    Scholze, Alexandra; Lamwers, Stephanie; Tepel, Martin; Sanner, Bernd M

    2012-01-01

    Obstructive sleep apnoea (OSA) is linked to increased cardiovascular risk. This risk can be reduced by nasal continuous positive airway pressure (nCPAP) treatment. As OSA is associated with an increase of several vasoconstrictive factors, we investigated whether nCPAP influences the digital volume...... automated analysis. In patients with OSA and an apnoea/hypopnoea index (AHI) of >10 events · h(-1), a significant vasoconstriction was observed during the night (p<0.0001 by Friedman's test). A significant positive correlation existed between vasoconstriction and AHI (Spearman correlation, r = 0.27; p<0.......01; n = 94) and the arousal index (Spearman correlation, r = 0.21; p < 0.05; n = 94). After 6 months of nCPAP treatment, the AHI was significantly reduced from 27 ± 3 events · h(-1) to 4 ± 2 events · h(-1) (each n = 29; p<0.001) and vasoconstriction during the night was significantly reduced from 10 ± 3...

  3. Liquid drops impacting superamphiphobic coatings.

    Science.gov (United States)

    Deng, Xu; Schellenberger, Frank; Papadopoulos, Periklis; Vollmer, Doris; Butt, Hans-Jürgen

    2013-06-25

    The dynamics of liquid drops impacting superamphiphobic coatings is studied by high-speed video microscopy. Superamphiphobic coatings repel water and oils. The coating consists of a fractal-like hydrophobized silica network. Mixtures of ethanol-water and glycerin-water are chosen to investigate the influence of interfacial tension and viscosity on spreading and retraction dynamics. Drop spreading is dominated by inertia. At low impact velocity, the drops completely rebound. However, the contact time increases with impact velocity, whereas the restitution coefficient decreases. We suggest that the drop temporarily impales the superamphiphobic coating, although the drop completely rebounds. From an estimate of the pressure, it can be concluded that impalement is dominated by depinning rather than sagging. With increasing velocity, the drops partially pin, and an increasing amount of liquid remains on the coating. A time-resolved study of the retraction dynamics reveals two well-separated phases: a fast inertia-dominated phase followed by a slow decrease of the contact diameter of the drop. The crossover occurs when the diameter of the retracting drop matches the diameter of the drop before impact. We suggest that the depth of impalement increases with impact velocity, where impalement is confined to the initial impact zone of the drop. If the drop partially pins on the coating, the depth of impalement exceeds a depth, preventing the whole drop from being removed during the retraction phase. PMID:23697383

  4. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving

    Directory of Open Access Journals (Sweden)

    Lorenz, Kai J.

    2014-05-01

    Full Text Available Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures.In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid.After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible.One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used.We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible.

  5. Nasal endotracheal intubation in a premature infant with a nasal encephalocele.

    OpenAIRE

    Bannister, C M; Kashab, M; Dagestani, H; Placzek, M

    1993-01-01

    After a difficult nasal intubation a premature infant leaked cerebrospinal fluid (CSF) from one nostril. After developing bacterial meningitis, the baby was referred for neurosurgical management of the CSF fistula. Transaxial computed tomograms demonstrated a nasal encephalocele, but coronal scans were needed to show the defect in the cribriform plate.

  6. Numerical study of the effect of the nasal cycle on unilateral nasal resistance.

    Science.gov (United States)

    Jo, Gyehwan; Chung, Seung-Kyu; Na, Yang

    2015-12-01

    We used computational fluid dynamics to study the effects of the nasal cycle on the modification of unilateral nasal resistance using nasal cavity models from 2 different patients with chronic rhinosinusitis. A steady airflow field with an inspiratory flow rate of 250 mL/s was simulated using ANSYS-FLUENT v14.5. The distribution of local unilateral nasal resistance showed different shapes of variation and magnitudes of resistance depending on the distribution of cross-sectional area in the nasal cavity models. The highest local resistance on the congested side was found near the nasal valve area in the first patient, whereas the highest value was found in the nasal vestibule for the second patient. The relative importance of nasal resistance in the turbinated air passage differed for the 2 patients. The unilateral resistance of the congested state was in the range of 0.0229-0.221 Pas/mL. In the inferior meatus, greater flow rate was allowed during the congested state than during the decongested state if an extensive backflow developed. PMID:26315663

  7. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving.

    Science.gov (United States)

    Lorenz, Kai J; Maier, Heinz; Wilde, Frank

    2014-01-01

    Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures. In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid. After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible. One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used. We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible. PMID:26504717

  8. Effects of nasal allergen challenge on dynamic viscoelasticity of nasal mucus.

    Science.gov (United States)

    Hattori, M; Majima, Y; Ukai, K; Sakakura, Y

    1993-04-01

    The effects of nasal provocation on the rheologic properties of nasal mucus were investigated in patients with allergic rhinitis provoked by house dust. The elastic modulus (G') and the dynamic viscosity (eta') of nasal mucus were determined by an oscillating sphere magnetic rheometer. Before and after the allergen challenge, G' increased, whereas eta' decreased with increasing oscillatory frequency; these findings indicate that the nasal mucus under these conditions is a non-newtonian fluid and has the cross-linked gel-like nature typical of mucus. Both G' and eta' values after nasal provocation were significantly lower than before. The values of G' and eta' after allergen challenge were in the optimal viscoelasticity range for mucociliary transport. PMID:8476173

  9. Clinical aspects of patients with nasal polyposis

    Directory of Open Access Journals (Sweden)

    Crespo, Cassio Caldini

    2009-09-01

    Full Text Available Introduction: The nasal Polyposis is a non-neoplastic chronic inflammatory process of the nasal mucosa. It causes a large impact to the patients' life quality. Objective: To analyze the characteristics of patients with polyposis in the Brazilian population. Method: 50 records of patients followed up in a tertiary hospital and submitted to surgical treatment of nasal polyposis were reviewed. The following variables were analyzed: age, sex, smoking, presence of asthma, presence of AAS intolerance and also the clinical manifestations: anterior and posterior rhinorrhea, nasal obstruction, hyposmia, sneezing and pruritus. The tomographic evaluation system applied was that of Lund-McKay. For statistical analysis we applied the chi-square test with p<0.05. Results: Out of 50 patients evaluated, 28 were male and 22 were female. The mean age range was of 40.8 years. The main clinical manifestation was nasal obstruction in 100% of the patients. In the tomographic evaluation, according to the Lund-McKay system, the average scoring was of 10.9. Discussion: No statistically significant difference was obtained in the patients' general symptoms compared to the patients with asthma or AAS intolerance. The difference in the Lund-McKay score was statistically significant in the populations studied. The symptoms were similar to the frequency of symptoms of other works. Conclusion: We concluded that the main complaint of the patients with nasal polyposis is nasal obstruction, the most affected age is of about 40 years old, without preference of sex. The severity of tomographic findings is higher in patients with asthma and AAS intolerance.

  10. Controlling charge on levitating drops.

    Science.gov (United States)

    Hilger, Ryan T; Westphall, Michael S; Smith, Lloyd M

    2007-08-01

    Levitation technologies are used in containerless processing of materials, as microscale manipulators and reactors, and in the study of single drops and particles. Presented here is a method for controlling the amount and polarity of charge on a levitating drop. The method uses single-axis acoustic levitation to trap and levitate a single, initially neutral drop with a diameter between 400 microm and 2 mm. This drop is then charged in a controllable manner using discrete packets of charge in the form of charged drops produced by a piezoelectric drop-on-demand dispenser equipped with a charging electrode. The magnitude of the charge on the dispensed drops can be adjusted by varying the voltage applied to the charging electrode. The polarity of the charge on the added drops can be changed allowing removal of charge from the trapped drop (by neutralization) and polarity reversal. The maximum amount of added charge is limited by repulsion of like charges between the drops in the trap. This charging scheme can aid in micromanipulation and the study of charged drops and particles using levitation. PMID:17580951

  11. Nasal commensal Staphylococcus epidermidis counteracts influenza virus

    Science.gov (United States)

    Chen, Hui-Wen; Liu, Pei-Feng; Liu, Yu-Tsueng; Kuo, Sherwin; Zhang, Xing-Quan; Schooley, Robert T.; Rohde, Holger; Gallo, Richard L.; Huang, Chun-Ming

    2016-01-01

    Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition between commensal bacteria and pathogenic species. We demonstrate here that S. epidermidis culture supernatants significantly suppressed the infectivity of various influenza viruses. Using high-performance liquid chromatography together with mass spectrometry, we identified a giant extracellular matrix-binding protein (Embp) as the major component involved in the anti-influenza effect of S. epidermidis. This anti-influenza activity was abrogated when Embp was mutated, confirming that Embp is essential for S. epidermidis activity against viral infection. We also showed that both S. epidermidis bacterial particles and Embp can directly bind to influenza virus. Furthermore, the injection of a recombinant Embp fragment containing a fibronectin-binding domain into embryonated eggs increased the survival rate of virus-infected chicken embryos. For an in vivo challenge study, prior Embp intranasal inoculation in chickens suppressed the viral titres and induced the expression of antiviral cytokines in the nasal tissues. These results suggest that S. epidermidis in the nasal cavity may serve as a defence mechanism against influenza virus infection. PMID:27306590

  12. Detection of Infectious Bovine Rhinotracheitis and Bovine Viral Diarrhea Viruses in the Nasal Epithelial Cells by the Direct Immunofluorescence Technique

    OpenAIRE

    Silim, A.; Elazhary, M. A. S. Y.

    1983-01-01

    Nasal epithelial cells were collected by cotton swabs for the diagnosis in experimental and field cases of infectious bovine rhinotracheitis and field cases of bovine viral diarrhea in calves. A portion of the cells was washed twice in phosphate buffered saline and a 25 µL drop was placed on microscope slides. The cells were dried, fixed and stained according to the direct fluorescent antibody technique. Another portion of the same specimen was inoculated onto primary bovine skin cell culture...

  13. In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum.

    Science.gov (United States)

    Inoue, Daisuke; Furubayashi, Tomoyuki; Ogawara, Ken-ichi; Kimura, Toshikiro; Higaki, Kazutaka; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira; Higashi, Yutaka

    2012-01-01

    Mucus on the nasal mucosa is translocated to the pharynx by ciliary beating, which is an important nonspecific defense mechanism called mucociliary clearance (MC). MC is one of the important factors determining the rate and extent of drug absorption after nasal application. The purpose of this study is to evaluate MC using rat nasal septum under physiological condition in an in vitro system. The nasal septum was excised from rats anesthetized with urethane and the movement of fluorescent microspheres (FMS) applied on the nasal septum was observed with a fluorescence microscope. FMS were transported at a constant velocity in the same direction for a few minutes, but addition of 4% mucin solution on the nasal septum maintained MC for at least 90 min after excision. With our evaluation system established by modifying the method of Saldiva, MC was determined to be around 1 mm/min. Furthermore, the ciliostatic effect of benzalkonium chloride was observed, and it was confirmed that β-adrenergic antagonists and a cholinergic antagonist decreased MC, and that β-adrenergic agonists and a cholinergic agonist tended to increase MC, indicating that our system is valid and useful for evaluating MC function and the effect of drugs and pharmaceutical additives for nasal application on MC. PMID:22687480

  14. Paediatric nasal polyps in cystic fibrosis.

    Science.gov (United States)

    Mohd Slim, Mohd Afiq; Dick, David; Trimble, Keith; McKee, Gary

    2016-01-01

    Patients with cystic fibrosis (CF) are at increased risk of nasal polyps. We present the case of a 17-month-old Caucasian patient with CF who presented with hypertelorism causing cycloplegic astigmatism, right-sided mucoid discharge, snoring and noisy breathing. Imaging suggested bilateral mucoceles in the ethmoid sinuses. Intraoperatively, bilateral soft tissue masses were noted, and both posterior choanae were patent. Polypectomy and bilateral mega-antrostomies were performed. Histological examination revealed inflammatory nasal polyposis typical of CF. The role of early functional endoscopic sinus surgery (FESS) in children with CF nasal polyposis remains questionable as the recurrence rate is higher, and no improvement in pulmonary function has been shown. Our case, however, clearly demonstrates the beneficial upper airway symptom relief and normalisation of facial appearance following FESS in a child with this condition. PMID:27329094

  15. Prenatal diagnosis of a nasal glioma.

    Science.gov (United States)

    Grzegorczyk, Véronica; Brasseur-Daudruy, Marie; Labadie, Gérard; Cellier, Cécile; Verspyck, Eric

    2010-10-01

    Nasal glioma is a rare congenital midline malformation composed of heterotopic masses of neuroglial tissue. We report a case of fetal nasal glioma diagnosed by sonography at 22 weeks' gestation as a vascular hypoechoic mass located on the left nasal bone. Fetal MRI excluded an underlying bone defect. At birth, the lesion appeared as a reddish mass. Post natal imaging confirmed the vascularisation within the lesion with an arterial low-flow velocity and a high-resistance spectrum, consistent with a glioma. The child underwent surgery at 5 months and final diagnosis was made on pathological examination. Therefore, a vascular lesion and a clinical aspect mimicking a haemangioma should not be considered sufficient to reach the final diagnosis. PMID:20401478

  16. Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension.

    Science.gov (United States)

    Faramarzi, Mohammad; Dadgarnia, Mohammad Hossein; Moghimi, Mansour; Sharouny, Hadi; Behniafard, Nasim

    2015-09-01

    Eosinophilic angiocentric fibrosis (EAF) is an extremely rare, chronic, benign, idiopathic disorder that mostly affects the upper respiratory tract, particularly the nasal cavity, and features progressive submucosal perivascular fibrosis. To the best of our knowledge, only seven cases of EAF with orbital involvement have been reported. We report a case of sinonasal EAF with orbital extension that presented with left nasolacrimal duct obstruction. A 35-year-old man presented with left epiphora, proptosis, anterolateral globe displacement and nasal obstruction. Endoscopic sinus examination showed a firm, gritty, creamy, yellow, fibrous, adherent mass of maxillary sinus. Diagnosis was established with histopathological examination of excisional biopsy of the lesion. Although EAF is very rare, it should be considered in the differential diagnosis of lesions of upper airway tract, particularly the nasal cavity. Biopsy is necessary for diagnosis and treatment planning. Resecting of the involved tissues completely is essential for prevention of recurrence. PMID:25601283

  17. Discriminating between Nasal and Mouth Breathing

    CERN Document Server

    Curran, Kevin; Coyle, Damian

    2010-01-01

    The recommendation to change breathing patterns from the mouth to the nose can have a significantly positive impact upon the general well being of the individual. We classify nasal and mouth breathing by using an acoustic sensor and intelligent signal processing techniques. The overall purpose is to investigate the possibility of identifying the differences in patterns between nasal and mouth breathing in order to integrate this information into a decision support system which will form the basis of a patient monitoring and motivational feedback system to recommend the change from mouth to nasal breathing. Our findings show that the breath pattern can be discriminated in certain places of the body both by visual spectrum analysis and with a Back Propagation neural network classifier. The sound file recoded from the sensor placed on the hollow in the neck shows the most promising accuracy which is as high as 90%.

  18. First drop dissimilarity in drop-on-demand inkjet devices

    International Nuclear Information System (INIS)

    As inkjet printing technology is increasingly applied in a broader array of applications, careful characterization of its method of use is critical due to its inherent sensitivity. A common operational mode in inkjet technology known as drop-on-demand ejection is used as a way to deliver a controlled quantity of material to a precise location on a target. This method of operation allows ejection of individual or a sequence (burst) of drops based on a timed trigger event. This work presents an examination of sequences of drops as they are ejected, indicating a number of phenomena that must be considered when designing a drop-on-demand inkjet system. These phenomena appear to be driven by differences between the first ejected drop in a burst and those that follow it and result in a break-down of the linear relationship expected between driving amplitude and drop mass. This first drop, as quantified by high-speed videography and subsequent image analysis, can be different in morphology, trajectory, velocity, and volume from subsequent drops within a burst. These findings were confirmed orthogonally by both volume and mass measurement techniques which allowed quantitation down to single drops.

  19. Nasal birth trauma: a review of appropriate treatment.

    LENUS (Irish Health Repository)

    Cashman, E C

    2012-02-01

    The aetiology of nasal deformity has frequently included birth trauma. There is no consensus in the literature as to whether nasal surgery, in the form of closed reduction, is indicated in neonates. The majority of studies in the literature that advocate intervention have inadequate followup periods and there is a paucity of evidence for the adverse effects of conservative management. This case highlights the therapeutic dilemma posed by such nasal injuries in the neonate and, to the best of the authors\\' knowledge, at the time of writing, represents the earliest reported case in the literature of nasal deformity in the neonate. The term nasal deformity is used to denote deformity of the nasal pyramid, soft tissue, and septum. Three main aspects of neonatal nasal deformity are addressed including, firstly, if nasal deformity at birth needs to be addressed, secondly, if left unaltered, what the long-term effects are and, finally, if intervention alters the normal course of midfacial development.

  20. Nanoparticles for nasal delivery of vaccines : monitoring adaptive immune responses

    NARCIS (Netherlands)

    Keijzer, C.

    2013-01-01

    The continuous emergence of new pathogens and growing drug resistance of microorganisms asks for innovative vaccination strategies. An alternative to conventional multiple injection vaccines is the nasal route of vaccine delivery. The immune response induced following nasal antigen delivery depends

  1. The nasal cavity microbiota of healthy adults

    OpenAIRE

    Bassis, Christine M.; Tang, Alice L.; Young, Vincent B.; Pynnonen, Melissa A

    2014-01-01

    Background The microbiota of the nares has been widely studied. However, relatively few studies have investigated the microbiota of the nasal cavity posterior to the nares. This distinct environment has the potential to contain a distinct microbiota and play an important role in health. Results We obtained 35,142 high-quality bacterial 16S rRNA-encoding gene sequence reads from the nasal cavity and oral cavity (the dorsum of the tongue and the buccal mucosa) of 12 healthy adult humans and dep...

  2. Surgical Treatment of Nasal Obstruction in Rhinoplasty.

    Science.gov (United States)

    Ghosh, Ankona; Friedman, Oren

    2016-01-01

    The key to a successful septorhinoplasty includes an understanding of nasal anatomy and physiology. This allows the surgeon the ability to properly address both form and function during the operation. History and physical examination are paramount in diagnosing and subsequently treating the epicenter of obstruction, which is commonly found among the internal and external nasal valve, the septum, or the turbinates. Treatment of each of these areas is nuanced and multiple approaches are discussed to provide an understanding of the current surgical techniques that allow for excellent functional and cosmetic rhinoplasty results. PMID:26616692

  3. Nasal mucociliary clearance in patients with tracheostomy

    OpenAIRE

    Yadav, S. P. S.; Janab, Khan Shariq; Singh, Jagat; Ranga, Rupender K.

    2003-01-01

    Nasal mucociliary clearance (NMC) time was estimated in 30 tracheostomized patients (24 males & 6 females) in the age group of 13–55 years which was 7.04±0.38 minutes: The patients suffering from nose and paranasal sinus disorders; taking drugs like bromhexine; undergoing radiotherapy and smokers were excluded from the study. The nasal mucociliary clearance in 30 age & sex matched healthy controls was 9.16±0.62 minutes. The NMC was found to he significantly lowered in patients with tracheosto...

  4. Primary Nasal Tuberculosis in a 10-Year-Old Girl

    Science.gov (United States)

    Özer, Murat; Özsurekçi, Yasemin; Cengiz, Ali Bülent; Özçelik, Uğur; Yalçın, Ebru; Gököz, Özay

    2016-01-01

    Nasal tuberculosis is a rare clinical entity which mainly presents in elderly people. Nasal tuberculosis has always been considered to be secondary to tuberculosis of the lungs, and in rare instances it is a primary infection, usually when mycobacteria are inhaled. We describe the case of a 10-year-old girl who was successfully treated for primary nasal tuberculosis. This patient is one of the very few children who have been reported to have primary nasal tuberculosis. PMID:27366187

  5. The use of nasal markers for monitoring mallard populations

    OpenAIRE

    Fabião, António; Rodrigues, David; Figueiredo, Maria

    2001-01-01

    We discuss the advantages and limitations of alphanumeric-coded nasal markers used for monitoring resident mallard populations. We tested two designs of nasal saddles, various colours, PVC tape of 2 thicknesses and ribber tape. The rctangular nasal saddle could disturb birds during feeding, so we changed it to a more anatomical design. The use of alphanumeric coded nasal markers was an efficient method for marking mallards in small wetlands with good visibility and for relatively short periods.

  6. Anthropometric Study of Nasal Index of the Kosovo Albanian Population

    OpenAIRE

    Gloria Staka; Fatmir Dragidella; Metush Disha

    2012-01-01

    Human nose occurs in many shapes and sizes and ethnic influences my results in different appearances of the nose. Nasal index is an ethnic sensitive anthropometric index. It is an important athropometric parameter for classifying the race and sex of the individual whose identity is unknown. This study was undertaken to determine the nasal index of the Kosovo Albanian population. The study sample comprised 204 subjects (101 males and 103 females) aged 18-25 years. Nasal height and nasal width ...

  7. Absorption of acetylsalicylic acid from the rat nasal cavity.

    Science.gov (United States)

    Hussain, A A; Iseki, K; Kagoshima, M; Dittert, L W

    1992-04-01

    The fate of salicylate in the plasma of rats was followed after nasal, intravenous, and oral administration of 2.0-mg doses of aspirin. Aspirin was well absorbed following nasal administration of a neutralized, nonirritating solution containing triethanolamine. The rate of absorption was slower than that of other nasally administered drugs, such as propranolol or progesterone. The bioavailability of aspirin following nasal administration was 100%, whereas the oral bioavailability was only 58.8% at the dose studied. PMID:1501071

  8. Intraosseous hemangioma of the nasal septum: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Min Ho; Kim, Eui Jong; Jang, Ji Hye; Lee, Kyung Mi; Choi, Woo Suk; Kim, Sung Wan; Kim, Yoon Hwa [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Hemangioma can arise in the soft tissues and bone of the nasal cavity. However, to the best of our knowledge, there are no prior case reports presenting intraosseous hemangioma of the nasal septum. Intraosseous hemangioma, in addition to a chondroid tumor, should be included in the differential diagnosis of a calcified mass of the nasal cavity. In the present report, we present a case of an intraosseous cavernous hemangioma in the nasal bony septum of a 53-year-old woman.

  9. Endoscopic removal of nasal septum chondrosarcoma in paediatric patient

    OpenAIRE

    Muhammad Nasri Abu Bakar; Rosdi Ramli; Zulkiflee Salahuddin; Irfan Mohamad

    2014-01-01

    Chondrosarcomas of the head and neck are uncommon malignant tumours of non-epithelial origin. They rarely occur in paediatric age group. The treatment is mainly surgical and adjuvant therapy is only reserved to certain cases. We report a boy with progressive history of nasal obstruction and epistaxis. Nasal endoscopy revealed a mass arising from nasal septum. Endoscopic excision of the tumour was successfully done followed by radiotherapy. Endoscopic excision of chondrosarcoma of the nasal...

  10. Excited Sessile Drops Dance Harmonically

    OpenAIRE

    Chang, Chun-Ti; Daniel, Susan; Steen, Paul H.

    2013-01-01

    In our fluid dynamics video, we demonstrate our method of visualizing and identifying various mode shapes of mechanically oscillated sessile drops. By placing metal mesh under an oscillating drop and projecting light from below, the drop's shape is visualized by the visually deformed mesh pattern seen in the top view. The observed modes are subsequently identified by their number of layers and sectors. An alternative identification associates them with spherical harmonics, as demonstrated in ...

  11. The NOFLO trial: low-flow nasal prongs therapy in weaning nasal continuous positive airway pressure in preterm infants.

    LENUS (Irish Health Repository)

    O'Donnell, Sinéad M

    2013-07-01

    To determine if low-flow nasal prongs therapy with room air, compared with no treatment, facilitates weaning from nasal continuous positive airway pressure (NCPAP) in very low birth weight (VLBW, birth weight <1500 g) infants.

  12. 21 CFR 868.5350 - Nasal oxygen catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nasal oxygen catheter. 868.5350 Section 868.5350...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5350 Nasal oxygen catheter. (a) Identification. A nasal oxygen catheter is a device intended to be inserted through a patient's nostril...

  13. Underlying Phoneme Velar Nasal with Lip Rounding in Hueyapan Nahuatl

    Science.gov (United States)

    Campbell, R. Joe

    1976-01-01

    Reasons are given for the idea that Hueyapan (Morelos) Nahuatl has an underlying velar nasal with lip rounding phoneme which never has the surface reflex of a rounded velar nasal allophone, but occurs phonetically as a velar nasal allophone or a labial dental voiced allophone or disappears. (SCC)

  14. 21 CFR 868.5340 - Nasal oxygen cannula.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nasal oxygen cannula. 868.5340 Section 868.5340...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5340 Nasal oxygen cannula. (a) Identification. A nasal oxygen cannula is a two-pronged device used to administer oxygen to a patient...

  15. The Effects of the Remanining Time of Anterior Nasal Packing in Nasal Passage on Healing After Septal Surgery

    OpenAIRE

    ÇETİNKAYA, Tufan

    2001-01-01

    One of the most disturbing problems to the patient after septal surgery is the presence of nasal packing. Postoperative nasal packing use has some advantages and disadvantages. This study was performed to determine whether there's a relation between the duration of postoperative nasal packing and patient complaints. A total of 66 patients undergoing septoplasty or septorhinoplasty were included into the study. The patients were divided into two groups according to the duration of nasal packin...

  16. Objective Measures in Aesthetic and Functional Nasal Surgery – Perspectives on Nasal Form and Function

    OpenAIRE

    Pawar, Sachin S.; Garcia, Guilherme J. M.; Kimbell, Julia S.; Rhee, John S.

    2010-01-01

    The outcomes of aesthetic and functional nasal surgery are difficult to assess objectively due to the intricate balance between nasal form and function. Despite historical emphasis on patient-reported subjective measures, objective measures are gaining importance in both research and the current outcomes-driven healthcare environment. Objective measures presently available have several shortcomings which limit their routine clinical use. In particular, the low correlation between objective an...

  17. How to Use Nasal Pump Sprays

    Science.gov (United States)

    Using Nasal Pump SpraysBlow your nose gently before using the spray. Prime the pump bottle by spraying it into the air a ... Breathe in quickly while squeezing down on the pump bottle one time. Repeat in other nostril. Do ...

  18. Nasal reconstruction with articulated irradiated rib cartilage

    International Nuclear Information System (INIS)

    Nasal structural reconstruction is a formidable task in cases where there is loss of support to both the nasal dorsum and tip. A multitude of surgical approaches and materials have been used for the correction of the saddle-nose deformity with varying degrees of success. Articulated irradiated rib cartilage inserted through an external rhinoplasty approach was used to reconstruct nasal deformities in 18 patients over a 6-year period. Simultaneous use of a midline forehead flap to reconstruct the overlying soft tissue was required in four cases. Follow-up ranged from 1 to 6 years (mean, 2.8 years). Results were rewarding in most cases with marked improvement in nasal support and airway. Revision and/or replacement secondary to trauma or warping of the graft was required in four cases. None of the patients exhibited infection, extrusion, or noticeable resorption. A description of the surgical technique, review of all the cases, and recommendation for continued use of this graft material are discussed

  19. Fracture of nasal bones: an epidemiologic analysis

    Directory of Open Access Journals (Sweden)

    Fornazieri, Marco Aurélio

    2008-12-01

    Full Text Available Introduction: One of the most common diseases in the otorhinolaryngology emergency room is the nasal bones fracture. The peak of incidence is between 15 and 25 years of age. Generally men are more affected. Objective: To analyze the age, gender and the most frequent causes of nasal fractures evaluated in the otorhinolaryngology service of a tertiary hospital. Method: Retrospective study of records of the patients with nasal fracture diagnosis treated between July 1st, 2003 and July 1st, 2007. Results: 167 patients with nasal bones fracture were included in the study, including 134 men and 33 women. Violence was the most frequent cause, with 55 cases (32.9%, followed by fall from their own height, with 33 cases (19.7%, and motorcycle accident, 14 cases (8.4%. The most common age was between 21 and 39 years (46.1%. Conclusion: Male, age between 21 and 39 years and violence are the most common characteristics found in our service. Motorcycle accidents also play an important role in this affection.

  20. High Flow Nasal Cannulae in preterm infants

    Directory of Open Access Journals (Sweden)

    F. Ciuffini

    2013-06-01

    Full Text Available Despite of improved survival of premature infants, the incidence of long term pulmonary complications, mostly associated with ventilation-induced lung injury, remains high. Non invasive ventilation (NIV is able to reduce the adverse effects of mechanical ventilation. Although nasal continuous positive airway pressure (NCPAP is an effective mode of NIV, traumatic nasal complications and intolerance of the nasal interface are common. Recently high flow nasal cannula (HFNC is emerging as an efficient, better tolerated form of NIV, allowing better access to the baby’s face, which may improve nursing, feeding and bonding. The aim of this review is to discuss the available evidence of effectiveness and safety of HFNC in preterm newborns with respiratory distress syndrome (RDS. It is known that distending pressure generated by HFNC increases with increasing flow rate and decreasing infant size and varies according to the amount of leaks by nose and mouth. The effects of HFNC on lung mechanics, its clinical efficacy and safety are still insufficiently investigated. In conclusion, there is a growing evidence of the feasibility of HFNC as an alternative mode of NIV. However, further larger randomized trials are required, before being able to recommend HFNC in the treatment of moderate respiratory distress of preterm infants.

  1. Pleomorphic adenoma of the nasal septum

    OpenAIRE

    Saxena, Sunil Kumar; Gopalakrishnan, S

    2003-01-01

    Despite the common occurrence of pleomorphic adenoma of major salivary glands, intranasal pleomorphic adenoma are rare. We present a ease of pleomorphic adenoma of the nasal septum along with a brief review of literature. The histological nature of this lesion in comparison to other salivary gland tumours and the importance of an accurate diagnosis has been stressed.

  2. Nasal reconstruction with articulated irradiated rib cartilage

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, C.S.; Cook, T.A.; Guida, R.A. (Univ. of Washington School of Medicine, Seattle (USA))

    1991-03-01

    Nasal structural reconstruction is a formidable task in cases where there is loss of support to both the nasal dorsum and tip. A multitude of surgical approaches and materials have been used for the correction of the saddle-nose deformity with varying degrees of success. Articulated irradiated rib cartilage inserted through an external rhinoplasty approach was used to reconstruct nasal deformities in 18 patients over a 6-year period. Simultaneous use of a midline forehead flap to reconstruct the overlying soft tissue was required in four cases. Follow-up ranged from 1 to 6 years (mean, 2.8 years). Results were rewarding in most cases with marked improvement in nasal support and airway. Revision and/or replacement secondary to trauma or warping of the graft was required in four cases. None of the patients exhibited infection, extrusion, or noticeable resorption. A description of the surgical technique, review of all the cases, and recommendation for continued use of this graft material are discussed.

  3. Tumor relapse present in oncologic nasal repair

    International Nuclear Information System (INIS)

    Introduction: Tumor relapse is one of the more fearsome complications of the oncologic course and also to obscure the life prognosis, causing the loss of many reconstructions and of exhausting the repairing surgical possibilities. The aim of this study was to determine the relapse frequency, the repercussion on the repair and the subsequent medical course of patients operated on malign nasal tumors. Methods: We made a retrospective and descriptive study in 20 patients operated on malign nasal tumors with immediate repair using frontal flap. Patients came from National Institute of Oncology and Radiobiology (NIOR), where they were seen from 2002 and 2007. Results: There were two relapses in 5 patients (25% of total), and the 80% of these were an epidermoid carcinoma. All patients with relapse lost the repaired tissues and received radiotherapy. Only it was possible to repair the defect in one of the patients; two of remained deceased, and were alive, without tumor relapse but without possibilities of repair. Conclusions: Considering the relapse frequency of nasal epidermoid carcinomas and of its repercussions when the Mhos histography technique is not available, it is advisable to delay the nasal repair until will be possible to confirm completely the histology of tumor exeresis. (author)

  4. Coblation nasal septal swell body reduction for treatment of nasal obstruction: a preliminary report.

    Science.gov (United States)

    Kim, So Jeong; Kim, Hee Tae; Park, Yun Hwi; Kim, Ju Yeon; Bae, Jung Ho

    2016-09-01

    In this paper, we present the results of coblation nasal septal swell body (NSB) reduction for the treatment of nasal obstruction in patients with abnormally thickened NSB. The study design was a retrospective clinical series conducted at a single tertiary medical center. Eight patients underwent coblation NSB reduction. Pre-operative and post-operative nasal functions were evaluated by acoustic rhinometry and subjective symptom scales. We also analyzed pre-operative CT scan images and nasal endoscopic findings. The mean maximal NSB width was 16.4 ± 2.2 mm on pre-operative coronal CT scan images. The mean visual analog scale score for nasal obstruction was decreased from preoperative 7.63 ± 0.99 points to 3.88 ± 0.92 points (postoperative 3 months), 4.16 ± 0.78 points (postoperative 6 months), and 4.63 ± 0.69 points (postoperative 1 year). Six out of the eight patients were satisfied with the clinical outcome at 1 year after the procedure. To the best of our knowledge, coblation NSB reduction has not yet been reported in the medical literature. Our results show that it can be an effective treatment modality for nasal valve narrowing in patients with abnormally thickened NSB. PMID:26912145

  5. Gas Pressure-Drop Experiment

    Science.gov (United States)

    Luyben, William L.; Tuzla, Kemal

    2010-01-01

    Most chemical engineering undergraduate laboratories have fluid mechanics experiments in which pressure drops through pipes are measured over a range of Reynolds numbers. The standard fluid is liquid water, which is essentially incompressible. Since density is constant, pressure drop does not depend on the pressure in the pipe. In addition, flow…

  6. Breakup of molten aluminum drops

    International Nuclear Information System (INIS)

    To clarify the entrapment of water and the breakup mechanism in molten Al drops, a series of experiments was carried out by pouring molten Al of 10 to 20 g (up to 1,000degC) into a highly subcooled-water pool (room temperature) through the air. A single large-scale water jet, which is capable of penetrating a molten Al drop, was found to appear above the molten Al drop immediately after an air column which the molten drop is dragging from the water surface, is detached. It was observed with a high frequency that a molten Al drop begins swelling first, and is then broken up during falling through the water pool or after hitting the basement. It was also found that the breakup always occurs in the course of solid crust formation, and the molten drop solidified without breakup forms a large cavity inside. Based on the experimental observations, it is concluded that the swelling and the breakup of a molten Al drop should be caused by the water entrapped inside and the hydrogen remaining super-saturated. It is reasonable to consider that an intensive breakup should be caused when some quantity of water is injected into a molten Al drop with a capability that a high-pressure vapor is generated due to a rapid release of latent heat just after brittle cracks occur during swelling. (author)

  7. Laser impact on a drop

    CERN Document Server

    Klein, Alexander L; Bouwhuis, Wilco; Lhuissier, Henri; Sun, Chao; Snoeijer, Jacco H; Villermaux, Emmanuel; Lohse, Detlef; Gelderblom, Hanneke

    2016-01-01

    The impact of a laser pulse on a highly absorbing liquid drop can lead to a violent response: the drop is accelerated, strongly deforms, and eventually fragments. Shock waves, the ejection of matter, and even plasma formation can accompany this process ...

  8. Pressure drop in contraction flow

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz

    This note is a supplement to Dynamic of Polymeric Liquids (DPL) page 178. DPL gives an equation for the pressure drop in a tapered (and circular) contraction, valid only at low angles. Here the general definition of contraction flow (the Bagley correction) and a more general method to find the...... pressure drop in a contraction are given....

  9. Elevation of soluble interleukin-2 receptor levels in nasal allergy

    OpenAIRE

    Hisamatsu, K.; T. Ganbo; Nakazawa, T; S. Horiguchi; Shimomura, S; Murakami, Y.

    1995-01-01

    To investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients (n = 26) compared with those of healthy subjects (n = 9). IL-2R-positive (CD25+) cells were observed in the crust formed in an allergic nasal mucosa. ...

  10. Nasal surgery in patients with systemic disorders

    Directory of Open Access Journals (Sweden)

    Sachse, Florian

    2010-01-01

    Full Text Available Multisystemic disorders represent a heterogenous group of diseases which can primarily manifest at the nose and paranasal sinuses as limited disease or secondarily as part of systemic involvement. Rhinologists therefore play an important role in the diagnostic but also therapeutic process. Although therapy of multisystemic disorders is primary systemic, additional rhinosurgery may become necessary. The spectrum of procedures consists of sinus surgery, surgery of the orbit and lacrimal duct, septorhinoplasty and closure of nasal septal perforation. Since the prevalence of most systemic diseases is very rare, recommendations are based on the analysis of single case reports and case series with a limited number of patients only. Although data is still limited, experiences published so far have shown that autologous cartilage or bone grafts can be used in nasal reconstruction of deformities caused by tuberculosis, leprosy, Wegener’s granulomatosis, sarcoidosis and relapsing polychondritis. Experiences gained from these diseases support the concept that well-established techniques of septorhinoplasty can be used in systemic diseases as well. However, a state of remission is an essential condition before considering any rhinosurgery in these patients. Even under these circumstances revision surgery has to be expected more frequently compared to the typical collective of patients undergoing septorhinoplasty. In addition, experiences gained from saddle nose reconstruction may in part be of value for the treatment of nasal septal perforations since implantation of cartilage grafts often represents an essential step in multilayer techniques of closure of nasal septal perforations. Aside from the treatment of orbital complications sinus surgery has been proven beneficial in reducing nasal symptoms and increasing quality of life in patients refractory to systemic treatment.

  11. RECENT TECHNIQUES IN NASAL DRUG DELIVERY: A REVIEW

    Directory of Open Access Journals (Sweden)

    Parmar Harshad

    2010-09-01

    Full Text Available Nasal drug administration has been used as an alternative route for the systemic availability of drugs restricted to intravenous administration. This is due to the large surface area, porous endothelial membrane, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including numerous compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in rapid systemic drug absorption. Approaches are discussed here for increasing the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. The article highlights the importance and advantages of the nasal drug delivery systems stressed upon bioadhesive properties. Bioadhesive, or more appropriately, mucoadhesive systems have been prepared for both oral and peroral administration in the past. The nasal mucosa presents an ideal site for bioadhesive drug delivery systems. In this review we discuss the effects of microspheres and other bioadhesive drug delivery systems on nasal drug absorption. Drug delivery systems, such as microspheres, liposomes and gels have been demonstrated to have good bioadhesive characteristics which swell easily when in contact with the nasal mucosa. These drug delivery systems have the ability to control the rate of drug clearance from the nasal cavity as well as protect the drug from enzymatic degradation in nasal secretions.

  12. Free Auricular Composite Graft for Acquired Nasal Stenosis

    Science.gov (United States)

    Riley, Charles A.; Lawlor, Claire M.; Gray, Mingyang Liu; Graham, H. Devon

    2016-01-01

    Background: Acquired nasal stenosis poses a reconstructive challenge for the facial plastic surgeon. Many surgical options are available, ranging from primary closure to skin grafts to free flap reconstruction for complex defects. The free auricular composite graft is a single-stage procedure that can be used to repair nasal vestibular stenosis causing nasal obstruction. Case Report: We present the case of a patient with acquired nasal stenosis as a result of prolonged nasal tampon placement secondary to severe epistaxis and subsequent nasal vestibular infection. Repair via auricular composite graft was successful, and we provide a thorough explanation of graft design and operative technique. Conclusion: Free auricular composite grafts can produce desirable functional and aesthetic outcomes and should be considered in patients presenting with acquired nasal stenosis. PMID:27303225

  13. Instant freezing of impacting wax drops

    Science.gov (United States)

    Ponomarenko, Alexandre; Virot, Emmanuel; Rubinstein, Shmuel

    2015-11-01

    We present the impact of hot liquid drops of wax on surfaces whose temperature is below the solidifying temperature of the drops. During the fall the drops remain mostly liquid, but upon impact, their temperature quickly decreases resulting in the solidification of the drop. Depending on the impact energy, drops size and the temperature difference between the drop and the surface this results in plethora of solid shapes: simple lenses, triangular drops, spherical caps and popped popcorn shapes.

  14. Electrokinetics of isolated electrified drops.

    Science.gov (United States)

    Pillai, Rohit; Berry, Joseph D; Harvie, Dalton J E; Davidson, Malcolm R

    2016-04-14

    Using a recently developed multiphase electrokinetic model, we simulate the transient electrohydrodynamic response of a liquid drop containing ions, to both small and large values of electric field. The temporal evolution is found to be governed primarily by two dimensionless groups: (i) Ohnesorge number (Oh), a ratio of viscous to inertio-capillary effects, and (ii) inverse dimensionless Debye length (κ), a measure of the diffuse regions of charge that develop in the drop. The effects of dielectric polarization dominate at low Oh, while effects of separated charge gain importance with increase in Oh. For small values of electric field, the deformation behaviour of a drop is shown to be accurately described by a simple analytical expression. At large electric fields, the drops are unstable and eject progeny drops. Depending on Oh and κ this occurs via dripping or jetting; the regime transitions are shown by a Oh-κ phase map. In contrast to previous studies, we find universal scaling relations to predict size and charge of progeny drops. Our simulations suggest charge transport plays a significant role in drop dynamics for 0.1 ≤ Oh ≤ 10, a parameter range of interest in microscale flows. PMID:26954299

  15. Pool impacts of Leidenfrost drop

    Science.gov (United States)

    Darbois Texier, Baptiste; Maquet, Laurent; Dorbolo, Stephane; Dehandschoewercker, Eline; Pan, Zhao; Truscott, Tadd

    2015-11-01

    This work concerns the impact of a droplet made of a volatile liquid (typically HFE) on a pool of an other liquid (typically silicone oil) which temperature is above the boiling point of the drop. Depending on the properties of the two liquids and the impacting conditions, four different regimes are observed. For low impacting speeds, the droplet bounces on the surface of the bath and finally levitates above it in a Leidenfrost state. Such a regime occurs as soon as the pool temperature exceeds the boiling point of the drop. This observation means that there is no threshold in temperature for a Leidenfrost effect on a liquid surface contrary to the case of a solid substrate. For intermediate impacting velocities, the pinch-off of the surface of the pool entraps the drop in the liquid bulk. The entrapped drop is separated from the pool by a layer of its own vapour in a similar way of antibulles. For increasing impacting speeds, the vapour layer between the drop and the pool does not hold during the pinch-off event. The contact of the drop with the hot liquid provokes a sudden and intense evaporation. At very large impacting speeds, the drop rapidely contacts the pool, spreads and finally induces a hemi-spherical cavity. In the end, these four different regimes are summarized in a Froud-Weber diagram which boundaries are discussed.

  16. The effect of nasalization on /a/ vowel formants before and after nasal consonant in 4-9-year old normal Persian speaking children

    OpenAIRE

    Kowsar Baghban; Farhad Torabinezhad; Negin Moradi; Akbar Biglarian

    2014-01-01

    Background and Aim : Nasalization of a vowel refers to the addition of nasal resonance to the vocal tract transfer function. Also, vowel nasalization occurs because of coarticulation. Coupling of the nasal resonating space to the oropharyngeal cavity alters the vocal tract formants in complex ways. The purpose of this study was to investigate the effect of nasalization on /a/ vowel formants in before and after nasal consonant.Methods: In current cross-sectional study, voice samples of 60 norm...

  17. Nasal Carriage of 200 Patients with Nasal Bone Fracture in Korea

    Directory of Open Access Journals (Sweden)

    Jun Wook Lee

    2013-09-01

    Full Text Available Background Pathogens in the nasal cavity during nasal surgery could lead to a systemicinfectious condition, such as bacteremia, nosocomial infection, or toxic shock syndrome.However, there is no research about the prevalence of nasal carriage in patients with nasalbone fracture.Methods This was a prospective, double-blind, randomized study about the rate of nasalcarriage in 200 patients with nasal bone fracture in Korea. Nasal secretions were taken fromboth the middle nasal meatus and colonized. All analyses were carried out using SPSS software.Results Pathogens were identified in 178 of the 200 cases. Coagulase-negative staphylococci(CNS were the most cultured bacteria in 127 (66.84% of the 190 total patients after excluding10 cases of contaminated samples, and methicillin-resistant coagulase-negative staphylococci(MRCNS were found in 48 (25.26%. Staphylococcus aureus was the second mostidentified pathogen, found in 36 (18.95%, followed by 7 cases (3.68% of methicillin-resistantStaphylococcus aureus (MRSA. The prevalence rate of MRSA in the females was higher thanthat in the males (RR=4.70; 95% CI, 1.09-20.18, but other demographic factors had no effecton the prevalence rate of MRSA and MRCNS.Conclusions The prevalence rate of these pathogens in patients with nasal bone fracture inKorea was similar to other reports. However, few studies have addressed the prevalence rateof CNS and MRCNS in accordance with risk factors or the change in prevalence according tospecific prophylaxis against infectious complications. Additional research is needed on thepotential connections between clinical factors and microbiological data.

  18. Excited Sessile Drops Perform Harmonically

    CERN Document Server

    Chang, Chun-Ti; Steen, Paul H

    2013-01-01

    In our fluid dynamics video, we demonstrate our method of visualizing and identifying various mode shapes of mechanically oscillated sessile drops. By placing metal mesh under an oscillating drop and projecting light from below, the drop's shape is visualized by the visually deformed mesh pattern seen in the top view. The observed modes are subsequently identified by their number of layers and sectors. An alternative identification associates them with spherical harmonics, as demonstrated in the tutorial. Clips of various observed modes are presented, followed by a 10-second quiz of mode identification.

  19. Adenoma pleomórfico de septo nasal: relato de caso Pleomorphic adenoma of the nasal septum: a case report

    Directory of Open Access Journals (Sweden)

    Mauren P. Rocha

    2004-06-01

    Full Text Available As neoplasias nasais são bastante raras. Os tumores mais observados na cavidade nasal são papilomas epiteliais, angiomas, carcinoma de células transicionais, carcinoma pavimentoso e adenocarcinoma. O adenoma pleomórfico pertence ao grupo de tumores que aparecem com menor freqüência na fossa nasal, e é o tumor benigno glandular mais comum originado na cabeça e pescoço. A apresentação clínica típica dos pacientes com adenoma pleomórfico do septo nasal é de obstrução nasal unilateral, epistaxe e massa indolor na cavidade nasal. Em vista da raridade da apresentação clínica do adenoma pleomórfico nesta localização, os autores descrevem um caso de adenoma pleomórfico nasal em um paciente do sexo masculino, com 69 anos de idade, onde relatam os achados clínicos, critérios diagnósticos, tratamento, prognóstico e revisão da literatura.Nasal tumours are very rare. The neoplasms most frequently seen in the nasal cavity are epithelial papillomas, angiomas, transitional cells carcinoma, pavement carcinoma and adenocarcinoma. The pleomorphic adenoma belongs to the group of tumours less commonly observed in the nasal cavity, and is the most common head and neck benign glandular tumour. The typical clinical presentation of the nasal pleomorphic adenoma is of unilateral nasal obstruction, epistaxis and a painless mass in the nasal cavity. The authors reported an adenoma pleomorphic case that highlights itself by its unusual nasal presentation in the nasal septum of a 45-year-old male patient who was submitted to surgical treatment, and discuss the clinical findings, diagnostic criteria, treatment, prognosis and literature review.

  20. Deposition of ultrafine aerosols in F344/N rat nasal casts

    International Nuclear Information System (INIS)

    Determination of regional respiratory deposition of inhaled aerosols is critical for evaluation of the health effects of air pollutants. Information on deposition of larger particles (> 0.02 μm) in the nasal passages of laboratory animals is available; the deposition fraction increases with increasing particle size. Little information on ultrafine particles less than 0.2 μm is available. Molds (models) were prepared from replica casts of the nasal passages of F344/N rats, using clear casting plastic. Total deposition of ultrafine aerosols in these casts was then determined using a unidirectional flow system. Measured pressure drops in the casts were a function of flow rate to the power of 1.4-1.6, indicating that the flow through the nasal passage was not laminar. Deposition data were obtained from these casts, using monodisperse sodium chloride aerosols with particle size ranging from 0.2 to 0.005 μm, at inspiratory and expiratory flow rates of 200 to 600 cc/min. Similar deposition data were obtained for the three casts studied. The deposition efficiency was greatest for the smallest particles, and decreased with increasing particle size and flow rate, indicating that diffusion was the dominant mechanism for deposition. At an inspiratory flow rate of 400 cc/min, which is comparable to a respiratory minute volume of 200 cc/min for mature male F344/N rats, deposition efficiencies reached 40 and 70% for 0.01 and 0.005 μm particles, respectively. Turbulent diffusion was considered to be the dominant mechanism for deposition of ultrafine particles in the nasal passage. This information is important for understanding the toxicity and carcinogenicity of submicrometer particles, including diesel soot, radon progeny and vapors. (author)

  1. External nasal dilators: definition, background, and current uses

    Directory of Open Access Journals (Sweden)

    Dinardi RR

    2014-11-01

    Full Text Available Ricardo Reis Dinardi, Cláudia Ribeiro de Andrade, Cássio da Cunha Ibiapina Department of Pediatrics, Pediatric Pulmonology Unit, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Abstract: Our goal was to revise the literature about external nasal dilators (ENDs as to their definition, history, and current uses. We reviewed journals in the PubMed and MEDLINE databases. The current uses hereby presented and discussed are physical exercise, nasal congestion and sleep, snoring, pregnancy, cancer, and healthy individuals. Numerous studies have shown that ENDs increase the cross-sectional area of the nasal valve, reducing nasal resistance and transnasal inspiratory pressure and stabilizing the lateral nasal vestibule, avoiding its collapse during final inspiration. These effects also facilitate breathing and are beneficial to patients with nasal obstruction. Furthermore, END use is simple, noninvasive, painless, affordable, and bears minimum risk to the user. Most studies have limited sample size and are mainly focused on physical exercise. In conclusion, ENDs seem useful, so further studies involving potential effects on the performance of physical tests and improvements in sleep quality are necessary, especially in children and teenagers. Keywords: external nasal dilator, nasal valve, nasal congestion, nasal resistance

  2. Differential Diagnosis of Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    London, Nyall R; Reh, Douglas D

    2016-01-01

    Nasal polyps are semi-translucent mucosal outgrowths of the paranasal sinuses which typically arise in the setting of chronic rhinosinusitis (CRS). Nasal polyps are also associated with asthma, aspirin sensitivity, cystic fibrosis and allergic fungal rhinosinusitis (AFS). The majority of nasal polyps are bilateral and characterized by tissue edema and eosinophil infiltration. Patients with nasal polyps often present with complaints including nasal obstruction, congestion, rhinorrhea or altered sense of smell. The differential diagnosis ranges from benign masses such as schneiderian papilloma, antrochoanal polyp, angiofibroma and encephalocele to malignant neoplasms such as squamous cell carcinoma (SCC), esthesioneuroblastoma, nasal lymphoma and rhabdomyosarcoma. These lesions may have a similar appearance as nasal polyps and particular attention to an alternative diagnosis for nasal polyps should be entertained if the mass is unilateral or congenital in nature. Workup for patients with a unilateral mass should include radiographic imaging, possible biopsy and careful follow-up when appropriate. Here, we review the disease etiology of nasal polyps and describe the approach to the patient with nasal polyps with emphasis on differential diagnosis and workup. PMID:27466841

  3. SEPTOPLASTY WITH AND WITHOUT NASAL PACKING: A COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Mitta

    2016-05-01

    Full Text Available Septoplasty is one of the most commonly performed surgeries in rhinology to relieve nasal obstruction of patients with distortion in the midline cartilage or septum of the nose to relieve nasal obstruction of patient and findings consistent with nasal endoscopy. The anterior nasal packing routinely done following septoplasty is usually conventional and not evidence based. The purpose of nasal packing is to obtain haemostasis, enhance opposition of septal flaps, avoid septal haematoma formation, close the dead space, avoid synechiae formation, provide support to septal cartilage and prevent its displacement. OBJECTIVE This study intends to evaluate the effects of nasal packing on surgical success and related complications in septoplasty. MATERIALS AND METHODS The present clinical prospective and randomised study was carried out on patients attending Otorhinolaryngology Department of Santhiram Medical College & General Hospital between March 2012 and March 2015. Patients undergoing septoplasty were randomised either to receive anterior nasal packing or to not receive nasal packing postoperatively. RESULTS Levels of pain experienced by patients with nasal packing postoperatively during the initial 24 hours postoperatively and during the removal of the pack were significantly more. Post-operative headache, epiphora, swallowing discomfort and sleep disturbance were more in patients with nasal packing and statistically (p.05. Septal haematoma, adhesions and local infections in both groups were statistically insignificant (p>.05. CONCLUSION Septoplasty enhances the standard of living of patients with septal deviation and nasal obstruction. Our study results suggest that nasal packing after septoplasty is not obligatory. Nasal packing causes considerably more pain and complications, and it should be reserved only for those who have bleeding predisposition.

  4. Drop spreading with random viscosity

    CERN Document Server

    Xu, Feng

    2016-01-01

    We examine theoretically the spreading of a viscous liquid drop over a thin film of uniform thickness, assuming the liquid's viscosity is regulated by the concentration of a solute that is carried passively by the spreading flow. The solute is assumed to be initially heterogeneous, having a spatial distribution with prescribed statistical features. To examine how this variability influences the drop's motion, we investigate spreading in a planar geometry using lubrication theory, combining numerical simulations with asymptotic analysis. We assume diffusion is sufficient to suppress solute concentration gradients across but not along the film. The solute field beneath the bulk of the drop is stretched by the spreading flow, such that the initial solute concentration immediately behind the drop's effective contact lines has a long-lived influence on the spreading rate. Over long periods, solute swept up from the precursor film accumulates in a short region behind the contact line, allowing patches of elevated v...

  5. Fundus imaging with a nasal endoscope

    Directory of Open Access Journals (Sweden)

    P Mahesh Shanmugam

    2015-01-01

    Full Text Available Wide field fundus imaging is needed to diagnose, treat, and follow-up patients with retinal pathology. This is more applicable for pediatric patients as repeated evaluation is a challenge. The presently available imaging machines though provide high definition images, but carry the obvious disadvantages of either being costly or bulky or sometimes both, which limits its usage only to large centers. We hereby report a technique of fundus imaging using a nasal endoscope coupled with viscoelastic. A regular nasal endoscope with viscoelastic coupling was placed on the cornea to image the fundus of infants under general anesthesia. Wide angle fundus images of various fundus pathologies in infants could be obtained easily with readily available instruments and without the much financial investment for the institutes.

  6. Assessment of the effect of deviated nasal septum on the structure of nasal cavity.

    Science.gov (United States)

    Wang, Junguo; Dou, Xin; Liu, Dingding; Song, Panpan; Qian, Xiaoyun; Wang, Shoulin; Gao, Xia

    2016-06-01

    The present study was aimed to investigate the effects of DNS on the structure of nasal cavity. The paranasal sinus coronal view CT of 108 patients with DNS and 129 hospitalized patients without DNS was retrospectively analyzed. The transverse diameter of nasal cavity (a), transverse diameter of nasal cavity and paranasal sinus (b), angle between maxillary and palatal bone, interalveolar distance, and maxillary rotation distance were measured. The ratio of a/b in experimental group was 0.367 ± 0.006 which was significantly (P = 0.0023) less than that in control group (0.391 ± 0.005). For the angle between maxillary and palatal bone, there was no significant difference found between DNS and control group for both right and left sides. The interalveolar distance was 40.75 mm in experimental group, and 38.8 mm in control (P = 0.0002). For the maxillary rotation distance, findings were considered as significant (P DNS affects the development of nasal cavity and paranasal sinus, as well as increases the interalveolar distance and maxillary rotation distance. These influences may be caused by the alteration of airflow inside the nasal cavities. PMID:26370235

  7. Reconstructing the extended nasal tip defect.

    Science.gov (United States)

    Mobley, Steven

    2013-10-01

    Reconstruction of large facial defects requires surgical skill, an understanding of engineering principles, an artistic eye, and patience to design the most elegant solution for each patient. Extended nasal tip defects, which may involve additional facial subunits, require even more thoughtful analysis and planning. Reconstructive surgeons need to be aware of the pros and cons of various options for flaps, the use of a delay stage, and sequencing and scheduling of staged operations to achieve an optimal outcome. PMID:24037937

  8. Brain-Targeted Nasal Clonazepam Microspheres

    OpenAIRE

    Shaji J; Poddar A; Iyer S

    2009-01-01

    Gelatin-chitosan mucoadhesive microspheres of clonazepam were prepared using the emulsion cross linking method. Mirospheres were evaluated using the in vitro and ex vivo drug release patterns. In vivo CNS drug distribution studies were carried out in rats by administering the clonazepam microspheres intra-nasally and clonazepam solution intravenously. From the drug levels in plasma and CSF, drug targeting index and drug targeting efficiency were calculated. Results obtained indicated that int...

  9. BLIND NASAL INTUBATION IN CRANIOROFACIAL TRAUMA

    Directory of Open Access Journals (Sweden)

    K.R.DavidThakaran

    2013-09-01

    Full Text Available Restricted mouth opening presents one of the greatest challenges to the anesthetist for endotracheal intubation and ventilation. Awake blind nasal intubation has been one of the finest and favored techniques for intubation in previous decades for restricted mouth opening patients. A coordinated team approach, monitoring and adequate counseling of the patient is mandatory for the airway management to carry out a safe surgical procedure

  10. Status of glutathione in nasal epithelium

    International Nuclear Information System (INIS)

    During inhalation exposure to air-born toxicants, the nasal epithelium may be subjected to local toxicity. Since glutathione (GSH) is often involved in xenobiotic metabolism, GSH status in these tissues has been examined. GSH content and apparent first-order rate constants for GSH content and apparent first-order rate constants for GSH turnover and synthesis were determined for respiratory epithelium covering the anterior ventral septum, olfactory epithelium covering the dorsal posterior septum, olfactory epithelium covering the dorsal meatus from male Fischer rats. The three tissues had similar concentrations of GSH (approximately 3-3.4 umol/g tissue) as determined by the Ellman's assay or by HPLC equipped with an electrochemical detector. Animals were administered [35S]Cysteine (Cys) by tail vein injection and rate constants were estimated, after incorporation of Cys into tissue GSH pools, by the decrease in GSH specific activity 1-102 hr after administration. Total [35S]GSH was analyzed by HPLC with a flow-through radioactivity detector. The three nasal epithelial tissues had similar apparent biphasic rates of GSH turnover, with rapid-phase half-lives of less than 10 hr and slow-phase half-lives of approximately 30 hr. The high GSH concentrations and the apparent rapid GSH turnover may facilitate the GSH-mediated detoxification within nasal tissue

  11. Evaluation of Fluticasone (Flixonase Nasal Spray Versus Beclomethasone (Beconase Nasal Spray in the Treatment of Allergic Rhinitis

    Directory of Open Access Journals (Sweden)

    Reza Farid

    2003-12-01

    Full Text Available Although response to intranasal steroid therapy has been reported in pa¬tients with allergic rhinitis, efficacy of some nasal steroids is noteworthy.This study was undertaken to evaluate the efficacy of a two-week course of Fluticasone (Flixonase nasal spray vs. Beclomethasone (beconase nasal spray in patients with symptoms of allergic rhinitis referred to our clinic. This study reviewed sixty randomized studies with symptoms of allergic rhinitis which sup¬ported common aeroallergens with skin prick test. Patients received a total daily dose of nasal spray of Fluticasone (Flixonase 100 meg bid (N=30 compared with patients with allergic rhinitis who received a total daily dose of Beclomethasone (Beconase 50mcg 2 puffs bid (N=30. Patients were visited before and after therapy, and efficacy of Flixonase. and Beconase was evaluated by the change in nasal symptoms including: nasal discharge, nasal obstruction, nasal itching, and sneezing. After two weeks of treatment nasal symptoms of blockage, discharge, sneezing and itching were significantly better in the group treated with Fluticasone nasal spray (65%, 82%, 67%, 79% respectively (/?100 meg bid Flixonase (Fluticasone intranasal spray is more effective than 50 meg 2 puffs bid Beconase (Beclomethasone intranasal spray. Like asthma, allergic rhinitis is an inflammatory disease and should be managed with anti-in¬flammatory medication.

  12. Electrostatic Liquid-Drop-Levitation System

    Science.gov (United States)

    Rhim, Won Kyu; Chung, San Kun; Hyson, Michael T.; Elleman, Daniel D.

    1988-01-01

    Electrostatic levitator has levitated drops of liquid up to 4 mm in diameter while maintaining spherical drop shapes. Stable levitation of spherical drops valuable in experiments involving super-cooling, solidification, and crystal growth.

  13. Anatomical study of nasal cartilage in buffalo (Bubalus bubulus

    Directory of Open Access Journals (Sweden)

    Mahdi Yeganehzad

    2011-07-01

    Full Text Available This study used ten heads of adult buffalo taken from slaughterhouse. After transferring the samples to the anatomy hall, a split was carefully created on skin of muzzle and the skin was slowly separated from muscles and hypodermal connective tissue. Place of connection of cartilages to bone, cartilages to each other and shape of the cartilages were specified. In buffalo, nose apex has two nostrils fixed by bone and cartilage. After identifying and separating the cartilages, it was found that nasal cartilages in buffalo consisted of: 1 septum nasal located between two nostrils and reinforces it from inside. 2 dorso-lateral nasal cartilage constituting dorsal and lateral parts of the nostril. 3 ventro-lateral nasal cartilage constituting ventral and lateral parts of the nostril. 4 lateral accessory cartilage constituting lateral and ventral parts of the nostril. 5 medial accessory nasal cartilage located at Alar fold and connected to ventro-lateral nasal cartilage.

  14. Dialectal and gender differences in nasalance for a Mandarin population.

    Science.gov (United States)

    Kim, Ha-Kyung; Yu, Xiao-Meng; Cao, Yan-Jing; Liu, Xiao-Ming; Huang, Zhao-Ming

    2016-01-01

    The purpose of this study was to determine whether there are dialectal and gender related differences in nasalance of main Mandarin vowels and three sentences in 400 Chinese normal adults. The mean nasalance score difference for dialect and gender was significant (p Beijing > Shanghai > Guangzhou for the nasal sentence, oro-nasal sentence, /a/, /i/ and /u/. In addition, the average nasalance scores of females were higher than those of males for all speech materials in all dialects. The clinical significance of this study can be helpful in making nasalance clinical decisions for Chinese people with cleft palate, hearing disorders and dysarthria with resonance disorders. It also shows the theoretical and socio-cultural features for linguists considering dialects and gender. PMID:26853731

  15. Nasal Septal Perforation Caused by Invasive Fungal Sinusitis

    Directory of Open Access Journals (Sweden)

    Wai-Tin Kuo

    2002-11-01

    Full Text Available Nasal septal perforation presents a distinct challenge to otorhinolaryngologists, and is aproblem for patients. Although it has a variety of causes, previous septal surgery is the mostcommon reason. We present a 57-year-old woman who had recurrent chronic sinusitis. Aleft nasal mass was noted and excised via endoscopic sinus surgery. Invasive aspergillosissinusitis was proven both grossly and histopathologically, and a nasal septal perforation wasalso noted during the operation. Although there has been only a single other case presentedby Siberry in 1997, we postulate that perforation of the nasal septum as with the casedescribed herein is a rare complication of invasive fungal sinusitis.

  16. Patient experience with mupirocin or povidone-iodine nasal decolonization.

    Science.gov (United States)

    Maslow, Jed; Hutzler, Lorraine; Cuff, Germaine; Rosenberg, Andrew; Phillips, Michael; Bosco, Joseph

    2014-06-01

    Led by the federal government, the payers of health care are enacting policies designed to base provider reimbursement on the quality of care they render. This study evaluated and compared patient experiences and satisfaction with nasal decolonization with either nasal povidone-iodine (PI) or nasal mupirocin ointment (MO). A total of 1903 patients were randomized to undergo preoperative nasal decolonization with either nasal MO or PI solution. All randomized patients were also given 2% chlorhexidine gluconate topical wipes. Patients were interviewed prior to discharge to assess adverse events and patient experience with their assigned preoperative antiseptic protocol. Of the 1903 randomized patients, 1679 (88.1%) were interviewed prior to discharge. Of patients receiving PI, 3.4% reported an unpleasant or very unpleasant experience, compared with 38.8% of those using nasal MO (P.05). Being recruited as an active participant in surgical site infection prevention was a positive experience for 87.2% of MO patients and 86.3% of PI patients (P=.652). Those assigned to receive PI solution preoperatively reported significantly fewer adverse events than the nasal MO group (P<.01). Preoperative nasal decolonization with either nasal PI or MO was considered somewhat or very helpful by more than two-thirds of patients. PMID:24972440

  17. A comparison of beclomethasone dipropionate aqueous nasal spray and beclomethasone dipropionate pressurized nasal spray in the management of seasonal rhinitis.

    OpenAIRE

    Dunn, A. M.; Wilson, R.S.; Baggott, P. J.

    1984-01-01

    Forty patients with seasonal rhinitis and a proven sensitivity to pollens were studied for 2 weeks during the pollen season of 1982. The study was carried out according to a double-blind, double-dummy design. All patients received 100 micrograms beclomethasone dipropionate (BDP) into each nostril twice daily (400 micrograms/day) on a randomized basis, from either the aqueous nasal spray or the pressurized nasal spray (Beconase Nasal Spray). Analysis of patients' symptom scores, additional sym...

  18. THE CORRELATION BETWEEN DERIVED NASALANCE MEASURES AND PERCEIVED NASALITY IN CHILDREN WITH REPAIRED CLEFT LIP AND PALATE

    Directory of Open Access Journals (Sweden)

    Attuluri Navya

    2014-04-01

    Full Text Available Context: Velopharyngeal dysfunction (VPD is one of the associated condition reported in individuals with repaired cleft lip and palate (RCLP leading to hypernasality. Nasality can be assessed by nasometer through nasalance values. But, mean nasalance values (N found to be overlapping between individuals with RCLP and normals. To overcome these limitations Nasalance Distance (ND and Nasalance Ratio (NR are derived based on nasalance range. Aims: The study is aimed to evaluate, correlate and compare acoustical (N, ND & NR and perceptual measures of nasality between the children with RCLP and control group. Settings and Design: Institutional setup and standard group comparison design Methods and Material: The study included fifteen children with RCLP ranging from 6 to 11 years and the control group consists of age and gender matched 15 typically developing children. Four point standard rating scale was used to rate the hypernasality by three speech language pathologists (SLP’s and Nasometer was used to measure the mean and derived nasalance scores for vowels and sentences in Kannada. Statistical analysis: SPSS, Cronbach’s Alpha test, multivariate analysis and Pearson’s product movement correlation were used to analyze the data. Results: Significant increase in the mean nasalance value and NR was seen in children with RCLP than the control group, whereas ND was contrary. ND was highly correlated with perceived nasality than N. The NR of sentences shows high negative correlation. Conclusions: The measures based on range of nasalance can be adapted to the routine clinical examinations for better correlation with perceived nasality.

  19. The effectiveness of nasal surgery on psychological symptoms in patients with obstructive sleep apnea and nasal obstruction.

    Science.gov (United States)

    Xiao, Yang; Han, Demin; Zang, Hongrui; Wang, Danni

    2016-06-01

    Conclusion Nasal obstruction can aggravate the psychological status of OSA patients, and nasal surgery should reduce this aggravation. Nasal surgery significantly improved sleep latency and ameliorated several polysomnographic characteristics. Background The aim of this study was to investigate the psychological status of patients with obstructive sleep apnea (OSA) and nasal obstruction and to evaluate the effects of nasal surgery on the psychological symptoms and polysomnographic (PSG) parameters of these patients. Methods The study was designed as a prospective comparative study. This study compared 30 patients (all male) with nasal obstruction and 30 matched patients without nasal obstruction using the Pittsburgh Sleep Quality Index (PSQI) and the Symptom Check List 90 (SCL-90). All of the patients had been previously diagnosed with OSA (apnea hypopnea index [AHI] ≥ 5 events/h) via a whole-night polysomnographic examination. Nasal obstruction was assessed using a visual analogue scale (VAS). The patients with nasal obstruction underwent nasal surgery, and their weight, VAS, nocturnal PSG characteristics, and psychological symptoms at baseline and 3 months after surgery were compared. Results The OSA patients with nasal obstruction suffered from significantly longer sleep latency on the PSQI and higher somatization and anxiety scores on the SCL-90 than the subjects without nasal obstruction (p symptoms significantly improved after surgery (VAS decreased from 6.18 ± 1.85 to 1.87 ± 1.76, p symptoms on the SCL-90 (p symptoms on the SCL-90, including inter-personal sensitivity, depression, hostility, paranoid ideation, psychoticism, global symptom index, and the number of positive symptoms (r > 0.3, p < 0.05). PMID:26903174

  20. What Are the Key Statistics about Nasal Cavity and Paranasal Sinus Cancers?

    Science.gov (United States)

    ... the key statistics about nasal cavity and paranasal sinus cancers? Cancers of the nasal cavity and paranasal sinuses ... section “ Survival rates for nasal cavity and paranasal sinus cancers, by stage. ” Last Medical Review: 04/22/2014 ...

  1. Randomized trial of prongs or mask for nasal continuous positive airway pressure in preterm infants.

    LENUS (Irish Health Repository)

    Kieran, Emily A

    2012-11-01

    To determine whether nasal continuous positive airway pressure (NCPAP) given with nasal prongs compared with nasal mask reduces the rate of intubation and mechanical ventilation in preterm infants within 72 hours of starting therapy.

  2. What's New in Nasal Cavity and Paranasal Sinus Cancer Research and Treatment?

    Science.gov (United States)

    ... What’s new in nasal cavity and paranasal sinus cancer research and treatment? There is always research going on ... ways to prevent nasal cavity and paranasal sinus cancers. Research on better treatment for nasal cavity and paranasal ...

  3. Epidemiology and burden of nasal congestion

    Directory of Open Access Journals (Sweden)

    Michael Stewart

    2010-02-01

    Full Text Available Michael Stewart1, BJ Ferguson2, Len Fromer31Department of Otorhinolaryngology, Weill Cornell Medical College, New York-Presbyterian Hospital/Weill Cornell Medical Center, USA; 2Department of Otolaryngology, University of Pittsburgh School of Medicine, USA; 3University of California, Los Angeles; David Geffen School of Medicine Los Angeles, California, USAAbstract: Nasal congestion, which may be described as fullness, obstruction, reduced airflow, or being “stuffed up,” is a commonly encountered symptom in clinical practice. Systematic study of congestion has largely considered it as a component of a disease state. Conditions associated with congestion include nasal polyposis, obstructive sleep apnea, and anatomic variation; however, most information on the burden of congestion comes from studies of allergic rhinitis and rhinosinusitis, diseases of which congestion is the major symptom. Congestion can be caused by other rhinologic conditions, such as non-allergic rhinitis, viral or bacterial rhinitis, and vasomotor rhinitis. Allergic rhinitis affects as much as one quarter of the population worldwide and imposes a significant economic burden. Additionally, allergic rhinitis significantly impairs quality of life; congestion causes allergic rhinitis sufferers decreased daytime productivity at work or school and reduces night-time sleep time and quality. Annually, rhinosinusitis affects tens of millions of Americans and leads to approximately $6 billion in overall health care expenditures; it has been found to be one of the most costly physical conditions for US employers. Given the high prevalence and significant social and economic burden of nasal congestion, this symptom should be a key consideration in treating patients with rhinologic disease, and there continues to be a significant unmet medical need for effective treatment options for this condition.Keywords: allergic rhinitis, congestion, epidemiology, obstruction, rhinosinusitis

  4. Changes in nasal resistance and nasal geometry using pressure and acoustic rhinometry in a feline model of nasal congestion

    DEFF Research Database (Denmark)

    McLeod, R.L.; Mingo, G.G.; Herczku, C.; Corboz, M.R.; DeGennaro-Culver, F.; Pedersen, Ole Finn; Hey, J.A.

    1999-01-01

    , increased nasal airway resistance (NAR) 1.2 +/- 0.6, 5.8 +/- 0.5, 8.6 +/- 1.1 and 7.9 +/- 1.5 cmH2O.L/minute, respectively. Increases in NAR produced by compound 48/80 were associated with a 395% increase in histamine concentration found in the nasal lavage fluid. Pretreatment with the alpha......-adrenoreceptor agonist, phenylpropanolamine (PPA; 0.1-3.0 mg/kg, i.v.), and the NO synthetase inhibitor, NG-nitro-L-arginine (L-NAME; 10 mg/kg, i.v.) attenuated the increases in NAR produced by compound 48/80. The histamine H1 antagonist chlorpheniramine (1.0 mg/kg, i.v.) and the H2 antagonist, ranitidine (1.0 mg/kg, i.......v.) had no decongestant activity. Also without decongestant activity were the muscarinic antagonist atropine, the cyclooxygenase inhibitor indomethacin, and the 5-HT blocker methysergide. Aerosolized histamine (0.1-1.0%) also produced a dose dependent increase in NAR. In studies using acoustic rhinometry...

  5. Septum nasal perforation: treatments and literature' review

    Directory of Open Access Journals (Sweden)

    Martinez Neto, Eulógio Emílio

    2010-03-01

    Full Text Available Introduction: The present study consists in a bibliographical' review concerning the articles related to the different manifestations and forms of the septum nasal perforation, with a main emphasis in the description of its techniques of surgical correction. As the etiology, that is fundamentally iatrogenic, accordingly surgical trauma. Other causes include exhibition to chemical industrial reagents, cocaine use, intranasal steroidal therapeutic, neoplasia and, infectious conditions. There is a few data concerning the prevalence of septum perforation in the general population. The decision making about surgical correction or medical treatment depend on the anatomic characteristics and of the pathogenesis of the septal perforation.

  6. Fronto-nasal Encephalocele. A Case Report

    Directory of Open Access Journals (Sweden)

    Rafael Ferrer Montoya

    2013-06-01

    Full Text Available Encephalocele is a herniation of the brain tissue through a congenital or acquired defect of the skull. The congenital condition is caused by a neural-tube defect attributable to an interaction among several genes and environmental factors. Anterior encephalocele is a rare entity and its incidence varies depending on the geographic area. We report the case of a newborn with a tumour protruding through the fronto-nasal region with a central pedunculated polypoid formation, in addition to the presence of bilateral cleft lip and palate. Surgical treatment was decided after consulting the Neurosurgery Department. This case report is interesting due to the rarity of this entity.

  7. Nasal soft tissue trauma and management.

    Science.gov (United States)

    Immerman, Sara; Constantinides, Minas; Pribitkin, Edmund A; White, W Matthew

    2010-12-01

    The nose is the most prominent of all facial structures and is susceptible to many types of trauma. All soft tissue injuries of the nose have the potential to distort its appearance and adversely affect the patient's self-image and self-esteem. Once life-threatening injuries are stabilized, a careful history and physical exam should be completed and treatment individualized. The ultimate objective of treatment is to achieve both functional and cosmetic restoration with timely diagnosis and repair. Immediate nasal reconstruction is ideal when medically possible because this decreases long-term sequelae. PMID:21086240

  8. [Nasal Highflow - Treatment option in severe hypoxaemia?].

    Science.gov (United States)

    Bräunlich, Jens; Wirtz, Hubert

    2015-12-01

    Nasal High Flow (NHF) provides a warmed and humidified air stream. In pediatrics, this method is already in widespread use and is increasingly replacing the CPAP. New studies show success in treating adults. Currently the acute hypoxemic insufficiency cause of pneumoniae is a secured area of use. NHF is not inferior in comparison to other oxygen delivery systems. At this juncture effectiveness of this easy to use method is not clear. Preliminary reports describe an improvement in ventilation by the NHF. Here, a wash-out of the airways and improved alveolar ventilation seem to be the main operating principles. PMID:26625231

  9. Evaporating Drops of Alkane Mixtures

    CERN Document Server

    Gu'ena, G; Poulard, C; Cazabat, Anne-Marie; Gu\\'{e}na, Geoffroy; Poulard, Christophe

    2005-01-01

    Alkane mixtures are model systems where the influence of surface tension gradients during the spreading and the evaporation of wetting drops can be easily studied. The surface tension gradients are mainly induced by concentration gradients, mass diffusion being a stabilising process. Depending on the relative concentration of the mixture, a rich pattern of behaviours is obtained.

  10. Size distribution of detached drops

    Science.gov (United States)

    Baluev, V. V.; Stepanov, V. M.

    1989-10-01

    The law governing the size distribution of detached gas-liquid streams of drops has been determined analytically, and a comparison is carried out against experimental data existing in the literature. The derived theoretical relationships offer an excellent description of existing experimental results.

  11. Effect of aspirin on nasal resistance to airflow.

    OpenAIRE

    Jones, A S; Lancer, J M; Moir, A A; Stevens, J. C.

    1985-01-01

    The effect of aspirin on nasal resistance to airflow was investigated by rhinomanometry in 25 healthy subjects before and after ingestion of aspirin or vitamin C in a double blind crossover trial. Aspirin caused a significant increase in nasal resistance compared with vitamin C. The effect of aspirin may be due to its inhibition of the synthesis of prostaglandins.

  12. Computed tomographic anatomy of the canine nasal passages

    International Nuclear Information System (INIS)

    A normal German shepherd dog underwent CT imaging with contiguous 10 mm thick images made of the nasal cavity from the caudal limit of the frontal sinuses to the rostral aspect of the nose. Normal structures were identified. This normal anatomic information will be of use in assessing CT images of dogs suspected of having nasal cavity disease

  13. Sensory neuropeptides and nitric oxide in nasal vascular regulation

    OpenAIRE

    Rinder, Johan

    1996-01-01

    Sensory neuropeptides and nitric oxide in nasal vascular regulation By Johan Rinder, M.D. Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institute, S- 171 77 Stockholm, Sweden and Department of Oto-Rhino-Laryngology, Karolinska Hospital, S-17176 Stockholm, SwedenThe role of sensory neuropeptides and nitric oxide in vascular regulation was investigated in the pig nasal mucosa...

  14. Nasal cytochrome P4502A: Identification in rats and humans

    Energy Technology Data Exchange (ETDEWEB)

    Thornton-Manning, J.R.; Hotchkiss, J.A. [Michigan State Univ., East Lansing, MI (United States); Ding, Xinxin [Wadsworth Center for Laboratories and Research, Albany, NY (United States)] [and others

    1995-12-01

    The nasal mucosa, the first tissue of contact for inhaled xenobiotics, possesses substantial enobiotic-metabolizing capacti. Enzymes of the nasal cavity may metabolize xenobiotics to innocuous, more water-soluble compounds that are eliminated from the body, or they may bioactivate them to toxic metabolites. These toxic metabolites may find to cellular macromolecules in the nasal cavity or be transported to other parts of the body where they may react. Nasal carcinogenesis in rodents often results from bioactivation of xenobiotics. The increased incidences of nasal tumors associated with certain occupations suggest that xenobiotic bioactivation may be important in human nasal cancer etiology, as well. The increasing popularity of the nose as a route of drug administration makes information concerning nasal drug metabolism and disposition vital to accomplish therapeutic goals. For these reasons, the study of xenobiotic-met abolizing capacity of the nasal cavity is an important area of health-related research. In the present study, we have confirmed the presence of CYP2A6 mRNA in human respiratory mucosa.

  15. Resident aerobic microbiota of the adult human nasal cavity

    DEFF Research Database (Denmark)

    Rasmussen, TT; Kirkeby Nielsen, LP; Poulsen, Knud;

    2000-01-01

    Recent evidence strongly suggests that the microbiota of the nasal cavity plays a crucial role in determining the reaction patterns of the mucosal and systemic immune system. However, little is known about the normal microbiota of the nasal cavity. The purpose of this study was to determine the m...

  16. HABRONEMOSE NASAL EM UMA ÉGUA

    Directory of Open Access Journals (Sweden)

    Fernanda Coutinho de Freitas

    2011-05-01

    Full Text Available A Habronemose é uma doença parasitária, e sua patogenia não está totalmente clara. Supõe-se que as larvas mortas ou que estão morrendo, desencadeiem uma reação de hipersensibilidade. Pode-se realizar tanto o tratamento clínico, como a exérese cirúrgica do granuloma caso seja necessária. O presente caso ilustra umaenfermidade das vias aéreas inferiores secundária a uma afecção parasitária atípica obstruindo o tecido nasal e adjacências. A terapia clínica instituída através da aplicação de neguvon intranasal, mostrou-se eficiente, não ocorrendo recidivas.The habronemiasis is a parasitic disease and its pathogenesis is not entirely clear. It is assumed that maggots dead or dying, eliciting a hypersensitivity reaction. You can perform both clinical treatment such as surgical excision of the granuloma if needed. This case illustrates a lower airway disease secondary to an atypical parasitic disease by blocking the nasal tissue and surroundings. Therapy clinic established by the application of intranasal neguvon, was efficient, with no recidivism.

  17. Treatment of nasal polyposis in Byzantine times.

    Science.gov (United States)

    Lascaratos, J G; Segas, J V; Assimakopoulos, D A

    2000-09-01

    The goal of this study was to describe the therapeutic methods and surgical techniques used during Byzantine times (AD 324-1453) for a disease that has occupied physicians since antiquity: nasal polyps. The original Greek-language texts of the Byzantine medical writers, most of which were published after the 17th century, were studied in order to identify the early knowledge of the definition, symptoms, conservative treatments, and surgical intervention in cases of this disease. A considerable number of conservative treatments, etiologic and local (with inunctions or blowing of caustic substances), with evident influence from Roman medicine, were identified even in the early Byzantine medical texts (4th century). Further, some surgical techniques were described that seem to constitute evolution of the Hippocratic tradition. From the study of the original texts of Byzantine medical writers, their interest in the rhinological diseases is evident; in the case of nasal polyps, new techniques were mentioned. The first meticulous intranasal surgical removal of polyps was described. These techniques, obviously developed during the Hellenistic period, initially influenced European medicine and later the rest of the world. PMID:11007093

  18. Anthropometric Study of Nasal Index of the Kosovo Albanian Population

    Directory of Open Access Journals (Sweden)

    Gloria Staka

    2012-12-01

    Full Text Available Human nose occurs in many shapes and sizes and ethnic influences my results in different appearances of the nose. Nasal index is an ethnic sensitive anthropometric index. It is an important athropometric parameter for classifying the race and sex of the individual whose identity is unknown. This study was undertaken to determine the nasal index of the Kosovo Albanian population. The study sample comprised 204 subjects (101 males and 103 females aged 18-25 years. Nasal height and nasal width were measured using an electronic digital caliper, with accuracy of 0.01 mm (Boss, Hamburg – Germany. Descriptive statistics showed that Kosovo Albanian males and females had mean nasal index of 67.07 ± 6.67 and 63.87 ± 5.56, respectively. The distribution of the nose types showed leptorrhine to be 76.96 % and dominant type among Kosovo – Albanian population.

  19. Correlation of nasal geometry with aerosol deposition in human volunteers

    International Nuclear Information System (INIS)

    The nasal airways act as the first filter in the respiratory tract to remove very large or small particles, that would otherwise penetrate to the lower airways. Aerosol deposition data obtained with human volunteers vary considerably under comparable experimental conditions. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. Because there is no direct proof of this hypothesis, nasal deposition of ultrafine particles in human volunteers has been studied in our laboratory. Preliminary results obtained with four adult volunteers also vary considerably between subjects. The purpose of this part of the study was to establish a theoretical equation relating diffusional deposition in nasal airways to the geometrical dimensions of the individual nasal airways. This relationship was then applied to the experimental deposition data and measurement of airway morphometry for correlation

  20. Nasal polyps. A clinical radiological histopathological and mycological study

    International Nuclear Information System (INIS)

    Forty patients with nasal polyposis were studied. This study included clinical, haematological and mycological aspects. There were 24 females (60% of patients) and 16 males (40%). We found that all patients presented with nasal obstruction and nasal tone and the majority of them had allergic nasal symptoms such as sneezing and watery discharge. Thirty five percent of the patients were recurrent cases, being operated before for nasal polyps. Radiological investigations showed high of sinusitis and that 10% of the patients had complicated disease with orbital or intracranial extensions. Mycological studies revealed the presence of fungal infection in 4 patient (10%) and it was caused by Aspergillus flavus. Histological studies identified the allergic nature of the polyps in all patients. Surgical treatment was carried out in all patients and operations varied from simple intranasal polypectomy, intranasal ethmiodectomy, external ethmoidectomy to Caldwell-Luc operation for patients with antrochanal polyps.(Author)

  1. Seasonal changes in nasal cytology in mite-allergic patients

    Directory of Open Access Journals (Sweden)

    Gelardi M

    2014-03-01

    Full Text Available Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs are a major cause of allergic rhinitis (AR and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens

  2. Diagnostic value of ultrasound for identification of nasal fracture

    Directory of Open Access Journals (Sweden)

    Nazanin Farshchian

    2011-07-01

    Full Text Available Background: Nasal fracture is a common fracture due to trauma. Gold standard method in diagnosis of nasal fracture is clinical examination and radiography is used in legal situation. Recently, ultrasound is recommended as a noninvasive and simple method in diagnosis of nasal fracture. This study investigates the role of ultrasound in diagnosis of nasal fracture.Methods: 126 cases with suspected nasal fracture were evaluated using both ultrasound and nasal radiography in compare with clinical examination as a gold standard and the results were evaluated statistically. Sensitivity, specificity, negative predictive value and positive predictive value, negative likelihood ratio and positive likelihood ratio were calculated with confidence interval 95%. Accuracy of both methods was also evaluated.Results: In clinical examination 111 cases (88.1% out of 126 cases, were diagnosed fractured and 15cases (11.9% were unfractured. From these 111 fracture cases, 108 cases in ultrasound and 92 in radiography evaluation were also diagnosed fractured. Ultrasound sensitivity, specificity and accuracy in diagnosis of nasal fracture were; 96.4% (91.1-98.6, 93.3% (70.2-98.8 and 96% respectively. Radiography report showed sensitivity 81.1% (72.8-87.3%, specificity 86.7% (62.1-96.3% and accuracy of 82%. Most sensitivity of both methods was in diagnosis of nasal dorsum fracture (100% in ultrasound and 92.6% in radiography. Most specificity of ultrasound was in diagnosis of lateral wall (100% and in radiography was in diagnosis of nasal dorsum fractures (50%.Conclusion: According to this findings ultrasound can used as a noninvasive method with high sensitivity and specificity to diagnosis of nasal fracture.

  3. Lavagem nasal como método de avaliação das cavidades nasais Nasal lavage as a tool to evaluate nasal cavities

    Directory of Open Access Journals (Sweden)

    Guilherme P. Caminha

    2001-01-01

    Full Text Available A avaliação das cavidades nasais é extremamente importante nos indivíduos portadores de patologias nasais e nos que estão expostos a substâncias potencialmente nocivas presentes no meio ambiente. Como a histologia da mucosa nasal é similar à das vias respiratórias inferiores, uma resposta inflamatória vista no nariz pode ser um sinal de alerta de inflamação na via aérea inferior. A presença de biomarcadores nas cavidades nasais pode ser facilmente detectada através de inúmeras técnicas. Entretanto, é necessário dispormos de um método para avaliação das alterações encontradas nesta região que seja simples e seguro. A lavagem nasal preenche estes critérios e deve ser considerada sempre que se deseje estudar esta região.The evaluation of the nasal cavities of subjects with nasal pathologies and those exposed to environmental contaminants is very important. Nasal mucosal histology is similar to that in the lower airways. Therefore, an inflammatory response seen in the nasal passages may be a warning signal of inflammation in the lower airways. Biomarkers in the nasal cavities can be easily detected in many ways. However, it is necessary to have a method of quantifying this effects that is safe and simple to perform. Nasal lavage fulfills these criteria and should be considered when studying this area.

  4. In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: the enhancing effect of potassium sorbate.

    Science.gov (United States)

    Bortolotti, Fabrizio; Fabrizio, Bortolotti; Balducci, Anna Giulia; Giulia, Balducci Anna; Sonvico, Fabio; Fabio, Sonvico; Russo, Paola; Paola, Russo; Colombo, Gaia; Gaia, Colombo

    2009-04-11

    Nasal spray products containing desmopressin acetate (DDAVP) were tested in vitro to evaluate the effect of the contained preservatives on drug permeation across rabbit nasal mucosa. Experiments were performed using Franz-type diffusion cells with rabbit nasal mucosa as model barrier. Transport profiles obtained in comparison with a preservative-free solution evidenced that in the presence of preservatives DDAVP permeation in vitro always increased (phypothesis that the two compounds formed an ion pair in solution with improved permeability was made. Additional experiments with aqueous test solutions reconstructed ad hoc containing desmopressin and varying sorbate concentrations confirmed the enhancing effect of sorbate, which however resulted to be independent of sorbate concentration. In conclusion, preservatives significantly enhanced desmopressin permeation in vitro across rabbit nasal mucosa with different mechanisms. If a correlation existed between these data and in vivo DDAVP bioavailability after nasal administration, this could strengthen the safety concerns related to the use of this medication in adults and children. PMID:19162181

  5. Drop impact on a fiber

    Science.gov (United States)

    Kim, Sung-Gil; Kim, Wonjung

    2016-04-01

    We present the results of a combined experimental and theoretical investigation of drop impact on a thin fiber. Using high-speed videography, we analyze the dynamics of droplet collision with a fiber. Based on the systematic experiments, we identify three outcomes of collision: capturing, single drop falling, and splitting. The outcomes are presented in a regime map, where the regime boundaries are explained through a scale analysis of forces. We also measure the liquid retention on the fiber after the droplet impact. By considering a liquid film on the fiber, we develop a mechanical model that predicts the residual water mass. Our model reveals that the residual mass depends critically on the fiber thickness and less on the impact speed. Our study can be extended to predicting the remaining droplet, critical problems in air filtration, water collection, and fiber coating.

  6. Dropped head syndrome in mitochondriopathy

    OpenAIRE

    Finsterer, J

    2004-01-01

    In a 63-year-old, 165-cm-tall woman with a history of repeated tick bites, dilative cardiomyopathy, osteoporosis, progressive head ptosis with neck stiffness and cervical pain developed. The family history was positive for thyroid dysfunction and neuromuscular disorders. Neurological examination revealed prominent forward head drop, weak anteflexion and retroflexion, nuchal rigidity, weakness of the shoulder girdle, cogwheel rigidity, and tetraspasticity. The lactate stress test was abnormal....

  7. Phenylephrine as an alternative to cocaine for nasal vasoconstriction before nasal surgery: A randomised trial

    Directory of Open Access Journals (Sweden)

    Sawsan T AlHaddad

    2013-01-01

    Full Text Available Background: Cocaine is often used topically to provide the profound vasoconstriction required for nasal surgery; however, it has been associated with intraoperative cardiac adverse effects. We compared cocaine with phenylephrine as an alternative to ascertain their relative efficacy as vasoconstrictors in nasal septoplasty. Methods: Adult patients, presenting for elective nasal septoplasty, of American Society of Anaesthesiologists physical status I-III, were randomised to either 0.5% phenylephrine or 4% cocaine. The primary outcome was quality of vasoconstriction on a 5-point scale (1=unacceptable, 5=excellent, rated by the surgeon at the end of the procedure. Results: Twenty-nine patients received phenylephrine and 26 received cocaine. The median rating for quality of the vasoconstriction was 4.0 (good in both the phenylephrine and cocaine groups ( P=0.84. Median blood loss was 50 ml in the phenylephrine group and 62.5 ml in the cocaine group ( P=0.49. In secondary analyses, phenylephrine was shown to be non-inferior to cocaine on both quality of vasoconstriction (non-inferiority delta of 1 point, P=0.009 and estimated blood loss (non-inferiority delta of 25 ml, P=0.028. The frequency of ventricular ectopy, ST segment changes or blood pressure changes after nasal packing was not significantly different between the two groups. Conclusion: Phenylephrine in a concentration of 0.5% is not different from 4% cocaine on the quality of vasoconstriction in septoplasty. Given the abuse potential of cocaine and the added administrative burden associated with its handling, phenylephrine might serve as an alternative.

  8. Fatty Acid Composition of Cultured Fibroblasts Derived from Healthy Nasal Mucosa and Nasal Polyps

    OpenAIRE

    Ayyad, Suha Jabr; Roca-Ferrer, Jordi; Picado, César

    2016-01-01

    Background: Fibroblasts from nasal polyps (NP) of asthma patients have reduced expression of cyclooxygenase 2 (COX-2) and production of prostaglandin E2 (PGE2). We hypothesized that the reported alterations are due to alterations in the availability of arachidonic acid (AA). Objective: The objective was to determine the fatty acid composition of airway fibroblasts from healthy subjects and from asthma patients with and without aspirin intolerance. Methods: We analyzed the fatty acid compositi...

  9. A rare case of mucoepidermoid carcinoma of the nasal septum

    Directory of Open Access Journals (Sweden)

    Barcellos, Alano Nunes

    2008-12-01

    Full Text Available Introduction: Mucoepidermoid carcinoma is the most common malignant neoplasm of the salivary glands, and the parotid is the main site of attack. It also occurs in the minor salivary glands from the nasal cavity to the lungs. Nasal location of the mucoepidermoid carcinoma is extremely rare. There is little literature on similar cases. Objective: To report a case of mucoepidermoid carcinoma of the right nasal septum, and cover general aspects of the pathogenesis, diagnosis, therapy, and post-operative follow-up. Case Report: We present a case of a 32-year-old patient with a history of nasal obstruction, epistaxis and tumoration in the right nasal cavity. The biopsy revealed it was a mucoepidermoid carcinoma. The tumor was surgically removed using endoscopes with associated complementary radiotherapy. The anatomopathological analysis classified it with a high degree of malignancy. We obtained remission of the symptoms and without subsequent recurrence. Conclusion: Tumor nasal masses should be studied with imaging and histopathology examinations. We may discover rare malignant nasal tumors.

  10. NASAL IN SITU GEL: A NOVEL DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Dhrupesh panchal

    2012-06-01

    Full Text Available Over the past few decades, advances in the in situ gel technologies have spurred development in manymedical and biomedical applications including controlled drug delivery. Many novel in situ gel baseddelivery matrices have been designed and fabricated to fulfill the ever increasing needs of thepharmaceutical and medical fields. In situ gelling systems are liquid at room temperature but undergogelation when in contact with body fluids or change in pH. In situ gel forming drug delivery is a type ofmucoadhesive drug delivery system. The formation of gel depends on factors like temperaturemodulation, pH change, presence of ions and ultraviolet irradiation from which the drug gets released ina sustained and controlled manner. Nasal delivery is a promising drug delivery option where commondrug administrations such as intravenous, intramuscular or oral are inapplicable. Recently, it has beenshown that many drugs have better bioavailability by nasal route than the oral route. This has beenattributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled withavoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in thegastrointestinal tract. The physiology of the nose presents obstacles but offers a promising route for noninvasivesystemic delivery of numerous therapies and debatably drug delivery route to the brain. Thusthis review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal drugabsorption mechanisms, various nasal drug delivery systems and their applications in drug delivery.

  11. Sense of smell in patients with bilateral nasal polyposis

    Directory of Open Access Journals (Sweden)

    Savović Slobodan N.

    2004-01-01

    Full Text Available Introduction Sense of smell is susceptible to various changes, both in physiological and in numerous pathological conditions. Of quantitative disorders of smell, hyposmia and anosmia are quite common, whereas of qualitative disorders parosmia is most frequent. The aim of this paper was to examine impact of bilateral nasal polyposis on olfactory function. Material and methods The research was carried out at the Nose, Ear and Throat Clinic in Novi Sad. It included 80 examinees, 40 (20 male, 20 female with bilateral nasal polyposis, while 40 examinees belonged to the control group (20 male, 20 female without symptoms of nasal polyposes. Fortunato-Niccolini olfactometer was used for this examination. Results and discussion In patients with bilateral nasal polyposis the average perception threshold values for examined odors were 15.50 ccm of odorous air, while in the control group they were 10,20 ccm of odorous air. The average identification threshold values for examined odors in patients with bilateral nasal polyposis were 18.80 ccm of odorous air, while in the control group they were 13.55 ccm of scented air. T-test showed that values of both tresholds were statistically significantly higher (p< 0,01 in patients with bilateral nasal polyposis in relation to the control group. Conclusion Olfactory deficit in patients with bilateral nasal polyposis is explained by difficult or impossible passage of odors into the olfactory region.

  12. Results of rhinoplasties of the nasal tip in Cienfuegos

    Directory of Open Access Journals (Sweden)

    Bernardo Félix Canto Vidal

    2015-04-01

    Full Text Available Background: the rhinoplasty of the nasal tip is one of the most difficult and challenging plastic surgeries the surgeon dedicated to the nasal deformities faces. Objective: exposing the results of the rhinoplasty accomplished to patients with nasal deformities. Methods: a descriptive study of results obtained in 145 patients who had a surgery to correct nasal deformities. They were attended at Dr. Gustavo Aldereguía Lima University General Hospital of Cienfuegos, in a period of 10 years. Results: in 56 patients surgery was headed for embracing the nasal tip; in 45 patients to the rotation of the nasal tip; and in 44 patients to the projection of the nasal tip. The technique of the banner with graft of cartilage of the septum and the ear was used. Conclusion: in the analyzed period, the rhinoplasty accomplished in the province of Cienfuegos had satisfactory results, because the patient’s expectations were satisfied with a reduction of the costs of risks for them due to the use of local anesthesia.

  13. PRL-3 expression in nasal sinus squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Zi-Hui Chen; Min-Ying Li

    2016-01-01

    Objective:To investigate the relationship between liver regeneration phosphatase-3 (PRL-3) with differentiation extent of nasal sinus squamous cell carcinoma, and molecular biological effects on the pathogenesis of nasal sinus squamous cell carcinoma to comprehend its relevance, so as to make early diagnosis of patients, and to give guidance to the prognosis. Methods:Immunohistochemistry was used to detect PRL-3 in 30 cases of different degrees of sinus nasal squamous cell carcinoma. 20 cases of normal nasal cavity of mucosa tissues were set as control. Results:The PRL-3 in all levels of sinonasal squamous cell carcinoma tissues, there was a significant difference compared with the normal nasal mucosa (P<0.05), squamous cell carcinoma and its expression increased with the grade with enhanced trend. Conclusions:PRL-3 expression increased significantly in sinonasal squamous cell carcinoma than in nasal polyp tissue, showed that it may be associated with squamous cell carcinoma of nasal sinus squamous cell carcinoma, may be the early event.

  14. An approach to the nasal septum in children.

    Science.gov (United States)

    Healy, G B

    1986-11-01

    Surgery of the nasal septum has long been discouraged in the pediatric population. Concerns about growth and development of the nose have led surgeons to adopt an extremely cautious attitude toward the correction of nasal septal deformities in childhood. More recently, studies have shown that with proper preservation of septal cartilage, surgery can be safely undertaken in this area. Frequently, however, exposure to the nasal septum is limited in small children due to the size of the nasal vestibule. Sublabial septoplasty has been safely carried out now in ten patients ranging in age from 4 to 9 years. This approach allows for complete access to the nasal septum while avoiding any external cosmetic deformity. The nasal septum has been preserved in all cases through morsalization and repositioning. Growth and development of the nose has been followed for up to 60 months without evidence of deformity or alteration. Sublabial septoplasty would, therefore, appear to be a safe and cosmetically acceptable approach to the correction of severe nasal septal deformities of childhood. PMID:3773624

  15. Non-Hodgkin's lymphoma of nasal cavity: CT diagnosis

    International Nuclear Information System (INIS)

    Objective: To study the CT imaging of nasal lymphomas and find out the relatively specific manifestations of CT imaging of nasal lymphomas. Methods: The CT imaging material of 10 nasal lymphomas confirmed pathologically and evaluate the diagnostic significance of the manifestations of the images combined with review of literatures. Results: The pathology of all 10 cases of nasal lymphomas were T cell Non-Hodgkin's lymphoma (NHL), Ann Arbor stage I-II in 9 and 1 in stage IV. The locations of 10 lymphomas were in the anterior portion of one of the nasal cavities, and the lymphomas extended posteriorly along the inferior and/or media nasalis concha in different extent. No bone structure destruction was found in all stage I cases and the bone of the media nasalis concha as well as the uncinate process was partially absorbed in the stage IV NHL. The skin of the external noses adjacent to the lymphoma of the whole 10 cases were swollen in various severity with disappearance of the subcutaneous fat. Conclusion: If that the tumor located in the anterior portion of nasal cavity, without destruction or deformation of the bone structure, the skin of the external nose adjacent to the tumor was swollen and/or the subcutaneous fat was disappeared shown by CT, the possibility of nasal lymphoma should be considered

  16. HABRONEMOSE NASAL EM UMA ÉGUA

    OpenAIRE

    Fernanda Coutinho de Freitas; Angélica Trazzi Bento de Moraes; Paula Pimentel Valente; Juliana Maria Avanci Agostinho; Geórgia Mode Magalhães

    2011-01-01

    A Habronemose é uma doença parasitária, e sua patogenia não está totalmente clara. Supõe-se que as larvas mortas ou que estão morrendo, desencadeiem uma reação de hipersensibilidade. Pode-se realizar tanto o tratamento clínico, como a exérese cirúrgica do granuloma caso seja necessária. O presente caso ilustra umaenfermidade das vias aéreas inferiores secundária a uma afecção parasitária atípica obstruindo o tecido nasal e adjacências. A terapia clínica instituída através da aplicação de negu...

  17. Brain-targeted nasal clonazepam microspheres

    Directory of Open Access Journals (Sweden)

    Shaji J

    2009-01-01

    Full Text Available Gelatin-chitosan mucoadhesive microspheres of clonazepam were prepared using the emulsion cross linking method. Mirospheres were evaluated using the in vitro and ex vivo drug release patterns. In vivo CNS drug distribution studies were carried out in rats by administering the clonazepam microspheres intra-nasally and clonazepam solution intravenously. From the drug levels in plasma and CSF, drug targeting index and drug targeting efficiency were calculated. Results obtained indicated that intranasally administered clonazepam microspheres resulted in higher brain levels with a drug targeting index of 2.12. Gelatin-chitosan cross linked mucoadhesive microspheres have the potential to be developed as a brain-targeted drug delivery system for clonazepam.

  18. Intra And Extra Nasal Laser Surgery

    Science.gov (United States)

    Selking, Stuart G.

    1988-06-01

    The author describes his experience with 400 intranasal laser surgical procedures done with the carbon dioxide laser and the surgical microscope. Procedures include excision and vaporization of polyps, turbinates, tumors, telangiectasia, synechia, nasal stenosis, intranasal cysts, papillomata, and septal spurs. The author describes a suction speculum and drape of his own design which provide smoke free access to the internal nose, and protection of the alar rim and the face from laser energy. Relief of obstruction is comparable to that obtained from the more traditional means of intranasal surgery. Intraoperative and early and delayed post operative bleeding is less with laser surgery than with any other means. Avoidance of technical problems is emphasized in this manuscript, since intranasal laser surgery is in some respects difficult to perform. Included are practical suggestions about patient positioning, use of protective devices, and patient selection.

  19. Clinical study and image diagnosis of nasal bone fracture

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Takenori; Suzuki, Naohiro; Okitsu, Takuji [Sendai City Hospital (Japan)

    2002-01-01

    In this study we reviewed the clinical features, diagnoses and treatments of 232 cases of nasal bone fracture cases treated at our department from January 1994 to June 2000. A marked predominance of males in the age range of 10-29 years was noted. Analysis of the causes of the nasal fractures were attributed to fighting (66 cases), traffic accidents (64 cases), sports (56 cases) and others (46 cases). The external appearance of nasal fractures were divided into 5 types, 85 cases of the displacement type, 27 cases of the depressed type, 32 of the mixed type, 56 of the non-deformation type and 32 of the unclassified type because of facial swelling. The sensitivity of conventional X-ray examination in identifying nasal fractures was 75.6%. Computed tomography scan (CT scan) was performed in 196 patients and showed that the middle and lower portions of nasal bones were fractured more easily than those of the upper portion. Nasal septum fracture occurred in 22 cases (11.2%). Other facial fractures combined with nasal fracture were found in 40 cases (20.4%). The type of combined fracture depended on the cause of the injury, for example, the combination of nasal and blow-out fracture was often caused by fighting, and many combined fractures of more than two facial bones resulted from traffic accidents. A total of 83 patients (35.8%) received reduction of the nasal bone fractures under general anaesthesia. The measurement of irradiation of each radiological examination revealed that the exposed dose of the newest model CT was similar to that of the conventional X-ray examination and tomography. (author)

  20. [One case of fungal sinusitis foreign body in nasal sinus].

    Science.gov (United States)

    Yan, Xudong; Li, Na; Liu, Pei

    2015-08-01

    A young female complained repeated nasal discharge for over three months with discomfort of right cheek, and oral antibiotics had less effect. She has a history of "root canal therapy" five years before. Physical examination found purulent secretion in the right middle nasal meatus, and light tenderness in the right side of the maxillary sinus area. The CT scan of paranasal sinus shown possible fungal infection of right maxillary sinus. Finally the nasal endoscopic surgery confirmed the fungus ball of right maxillary sinus with foreign body (the root canal filling material). PMID:26685411

  1. Surgical Approaches to the Nasal Cavity and Sinuses.

    Science.gov (United States)

    Weeden, Alyssa Marie; Degner, Daniel Alvin

    2016-07-01

    The nasal cavity and sinuses may be exposed primarily via a dorsal or ventral surgical approach. Surgical planning involves the use of advanced imaging, such as computed tomography or MRI. Surgical treatment of lesions of the nasal cavity usually is limited to benign lesions or can also be used in combination with adjunctive therapy, such as radiation therapy. Extreme caution must be exercised with a dorsal approach to the nasal cavity to avoid complications of inadvertent penetration into the brain case. Gentle tissue handling and careful closure of the mucoperiosteum must be exercised following a ventral approach to minimize the risk of oronasal fistula formation. PMID:27217006

  2. Star-shaped Oscillations of Leidenfrost Drops

    CERN Document Server

    Ma, Xiaolei; Burton, Justin C

    2016-01-01

    We experimentally investigate the self-organized, star-shaped oscillations of Leidenfrost drops. The drops levitate on a cushion of evaporated vapor over a heated, curved surface. We observe modes with $n = 2-13$ lobes around the drop periphery. We find that both the wavelength and frequency of the oscillations depend only on the capillary length of the liquid, and are independent of the drop radius and substrate temperature. However, the number of observed modes depend sensitively on the liquid viscosity. The dominant frequency of pressure variations under the drop is approximately twice that the drop oscillation frequency, consistent with a parametric forcing mechanism. Our results suggest that the star-shaped oscillations are hydrodynamic in origin, and are driven by capillary waves beneath the drop. The exact mechanism by which the vapor flow initiates the capillary waves is likely related to static "brim waves" in levitated, viscous drops.

  3. Drop dynamics on hydrophobic and superhydrophobic surfaces

    OpenAIRE

    Mognetti, B. M.; Kusumaatmaja, H.; Yeomans, J. M.

    2010-01-01

    We investigate the dynamics of micron-scale drops pushed across a hydrophobic or superhydrophobic surface. The velocity profile across the drop varies from quadratic to linear with increasing height, indicating a crossover from a sliding to a rolling motion. We identify a mesoscopic slip capillary number which depends only on the motion of the contact line and the shape of the drop, and show that the angular velocity of the rolling increases with increasing viscosity. For drops on superhydrop...

  4. Drop In - Experience the Taste

    OpenAIRE

    Lal, Sanjeev

    2014-01-01

    Wine is a growing industry and there are over 75,000 types of wine. Consumers are intimidated by the selection of wine and are afraid to ask questions of friends, bartenders, and retailers. Uneducated consumers also are reluctant to request samples of wine at liquor establishments. There are very few establishments in the downtown Vancouver area that offer a venue to sample the wine or educate the consumer. Drop In is an establishment that offers a pour or glass of different types of wine fro...

  5. Levocabastine eye drops are effective and well tolerated for the treatment of allergic conjunctivitis in children

    Directory of Open Access Journals (Sweden)

    Brunello Wüthrich

    1995-01-01

    Full Text Available This open-label, prospective, multicentre, 4-week trial was undertaken to assess the efficacy and tolerability of twice daily levocabastine eye drops (0.5 mg/ml, with sodium cromoglycate nasal spray for the relief of concurrent nasal symptoms if required, in a total of 233 children with seasonal allergic conjunctivitis. No correlation between efficacy, tolerability and age was found. Investigator assessments revealed that the total severity of ocular symptoms decreased by 84 ± 34% in patients < 12 years and 85 ± 30% in those ≥ 12 years, with corresponding reductions in the total severity of ocular findings of 84% in both patient groups over the 4-week treatment period. Global assessments of therapeutic efficacy revealed the effect of therapy on ocular symptoms to be excellent or good in 81% of patients < 12 years and 82% of those ≥ 12 years after 2 weeks of treatment, with corresponding values at the end of the trial of 88% and 82% in the two groups, respectively. Treatment tolerability was considered to be excellent or good by 94% of patients overall. Application site reactions were the most common adverse event associated with ocular levocabastine, occurring in 13% of patients < 12 years and 9% of those ≥ 12 years. Twice daily levocabastine eye drops therefore appear to be effective and well tolerated for the treatment of seasonal allergic conjunctivitis in children.

  6. 49 CFR 572.102 - Drop test.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Drop test. 572.102 Section 572.102 Transportation..., DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Free Motion Headform § 572.102 Drop... surface when the midsagittal plane is vertical. (4) Drop the headform from the specified height by...

  7. Oxygenation and Exercise Performance-Enhancing Effects Attributed to the Breathe-Right Nasal Dilator

    OpenAIRE

    Trocchio, Marc; Fisher, Jean; Wimer, Jeffrey W.; Parkman, Anna W.

    1995-01-01

    Recently, many professional football players have elected to wear spring-loaded nasal dilators during competition. Many athletes believe that wearing the “Breathe-Right” nasal dilator will increase nasal gas conduction and oxygenation to their body, subsequently improving their performance. The purpose of this experiment was to investigate the advantages of wearing a nasal dilator while performing aerobic and anaerobic exercise, as opposed to not wearing a nasal dilator. It was hypothesized t...

  8. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    OpenAIRE

    Wadell, Cecilia

    2002-01-01

    Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. Porcine nasal mucosa mounted in an Ussing chamber sys...

  9. Feasibility to implement the radioisotopic method of nasal mucociliary transport measurement getting reliable results

    International Nuclear Information System (INIS)

    Aim: Our goal was to implement the radioisotopic method to measure the nasal mucociliary velocity of transport (NMVT) in a feasible way in order to make it easily available as well as to validate the accuracy of the results. Such a method is needed when primary ciliary dyskinesia (PCD) is suspected, a disorder characterized for low NMVT, non-specific chronic respiratory symptoms that needs to be confirmed by electronic microscopic cilia biopsy. Methods: We performed one hundred studies from February 2000 until February 2002. Patients aged 2 months to 39 years, mean 9 years. All of them were referred from the Respiratory Disease Department. Ninety had upper or lower respiratory symptoms, ten were healthy controls. The procedure, done be the Nuclear Medicine Technologist, consists to put a 20 μl drop of 99mTc-MAA (0,1 mCi, 4 MBq) behind the head of the inferior turbinate in one nostril using a frontal light, a nasal speculum and a teflon catheter attached to a tuberculin syringe. The drop movement was acquired in a gamma camera-computer system and the velocity was expressed in mm/min. As there is need for the patient not to move during the procedure, sedation has to be used in non-cooperative children. Abnormal NMVT values cases were referred for nasal biopsy. Patients were classified in three groups. Normal controls (NC), PCD confirmed by biopsy (PCDB) and cases with respiratory symptoms without biopsy (RSNB). In all patients with NMVT less than 2.4 mm/min PCD was confirmed by biopsy. There was a clear-cut separation between normal and abnormal values and interestingly even the highest NMVT in PCDB cases was lower than the lowest NMVT in NC. The procedure is not as easy as is generally described in the literature because the operator has to get some skill as well as for the need of sedation in some cases. Conclusion: The procedure gives reliable, reproducible and objective results. It is safe, not expensive and quick in cooperative patients. Although, sometimes

  10. Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies.

    Science.gov (United States)

    Sintov, Amnon C; Levy, Haim V; Botner, Shafir

    2010-12-01

    The main purpose of this study was to investigate the nasal absorption of insulin from a new microemulsion spray preparation in rabbits. The bioavailability of insulin lispro via the nasal route using a W/O microemulsion was found to reach 21.5% relative to subcutaneous administration, whereas the use of an inverse microemulsion as well as a plain solution yielded less than 1% bioavailability. The profile of plasma glucose levels obtained after nasal spray application of the microemulsion (1IU/kg lispro) was similar to the subcutaneous profile of 0.5IU/kg at the first 90min after application and resulted in a 30-40% drop in glucose levels. The microemulsion system was characterized by DLS, TEM, viscosity measurements, and by construction of pseudo-ternary phase diagram. The average droplet size of an insulin-unloaded and insulin-loaded microemulsions containing 20% aqueous phase (surfactants-to-oil ratio=87:13) was 2nm and 2.26nm in diameter, respectively. In addition, the effect of the microemulsion on FITC-labeled insulin permeation was examined across the porcine nasal mucosa in vitro. The permeability coefficient of FITC-insulin via the microemulsion was 0.210±0.048cm/h with a lag time of 10.9±6.5min, whereas the permeability coefficient from a plain solution was 0.082±0.043cm/h with a lag time of 36.3±10.1min. In view of the absorption differences of insulin between 20%, 50% water-containing microemulsions and an aqueous solution obtained in vitro and in vivo, it has been concluded that the acceleration in the intramucosal transport process is the result of encapsulating insulin within the nano-droplet clusters of a W/O microemulsion, while the microemulsion ingredients seems to have no direct role. PMID:20709120

  11. Nasal Aspergillosis in a Dog: A Case Report

    Directory of Open Access Journals (Sweden)

    Camilo Padilla Peñuela

    2014-07-01

    Full Text Available Nasal aspergillosis is a major chronic disease affecting the nostrils in dogs. Clinical sinology is typical in every chronic nasal disease. Epistaxis and occasional pain occurs. Rhinoscopic assessment of the area evidences findings associated with the pathology and allows collecting samples for cytology and culture. Systemic therapy with oral antifungals has had variable utility, but now it has been replaced by direct topical medication to the affected area. This article describes the case of a 4-years-old male dog, submitted to consultation by unilateral muco-bloody nasal discharge with a week of evolution. The patient was treated by another vet center with cyclonamine and vitamin K for a possible clotting disorder. After a series of tests that included rhinoscopy and fungal culture, nasal aspergillosis was diagnosed. Intranasal clotrimazole was applied twice and it allowed the resolution of the clinical signs.

  12. How Are Nasal Cavity and Paranasal Sinus Cancers Staged?

    Science.gov (United States)

    ... by stage How are nasal cavity and paranasal sinus cancers staged? Staging is a process that tells ... cavity or ethmoid sinuses. T categories for maxillary sinus cancer TX: Primary (main) tumor cannot be assessed. ...

  13. Nasal septum perforation in patient with pyoderma gangrenosum

    Directory of Open Access Journals (Sweden)

    Maia, Camilla Bezerra da Cruz

    2012-01-01

    Full Text Available Introduction: The cocaine is obtained from the leaves of the coca (Erythroxylon coca. It can be used in many ways, but the most common is the drug inhalation. The Cocaine also causes vasoconstriction at nasal mucous membrane and its chronic use can cause necrosis and nasal septum perforation. Pyoderma gangrenosum is an uncommon idiopathic disease characterized by ulcerations, usually observed on the legs. Its diagnosis is most common an exclusion of others diseases. So far, there is no specific treatment based on evidence by randomized controlled trials. Objective: Describe the rare association between Pyoderma gangrenosum and cocaine. Case Report: E. A., 27-year-old woman with destruction of nasal septum and palate who has been using a big amount of cocaine, been necessary note the difference from which disease cause de damage. Final Comments: Also there are only three cases of Pyoderma gangrenosum complicated with nasal septum perforation in cocaine users.

  14. Zicam-induced damage to mouse and human nasal tissue.

    Directory of Open Access Journals (Sweden)

    Jae H Lim

    Full Text Available Intranasal medications are used to treat various nasal disorders. However, their effects on olfaction remain unknown. Zicam (zinc gluconate; Matrixx Initiatives, Inc, a homeopathic substance marketed to alleviate cold symptoms, has been implicated in olfactory dysfunction. Here, we investigated Zicam and several common intranasal agents for their effects on olfactory function. Zicam was the only substance that showed significant cytotoxicity in both mouse and human nasal tissue. Specifically, Zicam-treated mice had disrupted sensitivity of olfactory sensory neurons to odorant stimulation and were unable to detect novel odorants in behavioral testing. These findings were long-term as no recovery of function was observed after two months. Finally, human nasal explants treated with Zicam displayed significantly elevated extracellular lactate dehydrogenase levels compared to saline-treated controls, suggesting severe necrosis that was confirmed on histology. Our results demonstrate that Zicam use could irreversibly damage mouse and human nasal tissue and may lead to significant smell dysfunction.

  15. Electrohydrodynamics of a viscous drop with inertia

    Science.gov (United States)

    Nganguia, H.; Young, Y.-N.; Layton, A. T.; Lai, M.-C.; Hu, W.-F.

    2016-05-01

    Most of the existing numerical and theoretical investigations on the electrohydrodynamics of a viscous drop have focused on the creeping Stokes flow regime, where nonlinear inertia effects are neglected. In this work we study the inertia effects on the electrodeformation of a viscous drop under a DC electric field using a novel second-order immersed interface method. The inertia effects are quantified by the Ohnesorge number Oh, and the electric field is characterized by an electric capillary number CaE. Below the critical CaE, small to moderate electric field strength gives rise to steady equilibrium drop shapes. We found that, at a fixed CaE, inertia effects induce larger deformation for an oblate drop than a prolate drop, consistent with previous results in the literature. Moreover, our simulations results indicate that inertia effects on the equilibrium drop deformation are dictated by the direction of normal electric stress on the drop interface: Larger drop deformation is found when the normal electric stress points outward, and smaller drop deformation is found otherwise. To our knowledge, such inertia effects on the equilibrium drop deformation has not been reported in the literature. Above the critical CaE, no steady equilibrium drop deformation can be found, and often the drop breaks up into a number of daughter droplets. In particular, our Navier-Stokes simulations show that, for the parameters we use, (1) daughter droplets are larger in the presence of inertia, (2) the drop deformation evolves more rapidly compared to creeping flow, and (3) complex distribution of electric stresses for drops with inertia effects. Our results suggest that normal electric pressure may be a useful tool in predicting drop pinch-off in oblate deformations.

  16. Small drops from large nozzles

    Science.gov (United States)

    Castrejon-Pita, Alfonso Arturo; Said Mohamed, Ahmed; Castrejon-Pita, Jose Rafael; Herrada, Miguel Angel

    2015-11-01

    We report experimental and numerical results of the generation of drops which are significantly smaller than the nozzle from which they are generated. The system consists of a cylindrical reservoir and two endplates. One plate is a thin metal sheet with a small orifice in its centre which acts as the nozzle. The other end consists of a piston which moves by the action of an elecromechanical actuator which in turn is driven by sine-shape pull-mode pulses. The meniscus (formed at the nozzle) is thus first overturned, forming a cavity. This cavity collapses and a thin and fast jet emerges from its centre. Under appropriate conditions the tip of this jet breaks up and produces a single diminutive drop. A good agreement between the experimental and numerical results was found. Also, a series of experiments were performed in order to study the effects that the pulse amplitude and width, together with variations in the liquid properties, have over the final size of the droplet. Based on these experiments, a predictive law for the droplet size has been derived. This work was funded by the Royal Society (University Research Fellowship and Research Grant), the John Fell Fund (Oxford University Press), the Ministry of Science and Education (DPI2013-46485 Spain), and the Junta de Andalucia (P08-TEP-31704128 Spain).

  17. Nasal mucosa in workers exposed to formaldehyde: a pilot study.

    OpenAIRE

    Boysen, M; Zadig, E; Digernes, V; Abeler, V; Reith, A.

    1990-01-01

    This study evaluates the histological changes, especially the presence of possible precancerous lesions, in the nasal mucosa of workers exposed to formaldehyde. Nasal biopsies of 37 workers occupationally exposed to formaldehyde for more than five years and 37 age matched referents showed a higher degree of metaplastic alterations in the former group. In addition, three cases of epithelial dysplasia were observed among the exposed. These results indicate that formaldehyde may be potentially c...

  18. BILATERAL NASOLABIAL CYST: A RARE CAUSE OF NASAL OBSTRUCTION

    OpenAIRE

    Samir

    2015-01-01

    Nasolabial cyst is rare, nonodontogenic, soft tissue, and developmental cyst. It is located inferior to the nasal ala. It is frequently asymptomatic, we report a rare case of bilateral nasolabial cysts causing nasal obstruction. This case report provides review of current knowledge adout pathogenesis, symptoms, imaging modalities, histopathology, treatment options and prognosis of nasolabial cyst. A 30 years old woman presented with swelling below the nose around the upper lip...

  19. A Solitary Malignant Schwannoma in the Choana and Nasal Septum

    OpenAIRE

    Eun Jung Lee; Kee Jae Song; Yeon Suk Seo; Kyung-Su Kim

    2014-01-01

    Malignant schwannoma is an extremely rare tumor and the risk of malignant schwannoma increases in patients with von Recklinghausen's disease. Recently, we encountered a case of solitary malignant schwannoma in the choana and posterior nasal septum. Malignant schwannoma has not been previously reported in these locations. A 53-year-old man, who was immunologically healthy and showed no abnormal dermatological lesions, presented with a polypoid mass in the right nasal cavity and underwent endos...

  20. Formulation of a dry powder influenza vaccine for nasal delivery

    OpenAIRE

    Garmise, Robert J.; Mar, Kevin; Crowder, Timothy M.; Hwang, C. Robin; Ferriter, Matthew; Huang, Juan; Mikszta, John A.; Sullivan, Vincent J.; Hickey, Anthony J.

    2006-01-01

    The purpose of this research was to prepare a dry powder vaccine formulation containing whole inactivated influenza virus (VIIV) and a mucoadhesive compound suitable for nasal delivery. Powders containing WIIV and either lactose or trehalose were produced by lyophilization. A micro-ball mill was used to reduce the lyophilized cake to sizes suitable for nasal delivery. Chitosan flakes were reduced in size using a cryo-milling technique. Milled powders were sieved between 45 and 125 μm aggregat...

  1. RECENT TECHNIQUES IN NASAL DRUG DELIVERY: A REVIEW

    OpenAIRE

    Parmar Harshad; Bhandari Anand; Shah Dushyant

    2010-01-01

    Nasal drug administration has been used as an alternative route for the systemic availability of drugs restricted to intravenous administration. This is due to the large surface area, porous endothelial membrane, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including numerous compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the ...

  2. Scientific Considerations for Generic Synthetic Salmon Calcitonin Nasal Spray Products

    OpenAIRE

    Lee, Sau L.; Yu, Lawrence X.; Cai, Bing; Johnsons, Gibbes R.; Rosenberg, Amy S.; Cherney, Barry W.; Guo, Wei; Raw, Andre S.

    2010-01-01

    Under the Abbreviated New Drug Application pathway, a proposed generic salmon calcitonin nasal spray is required to demonstrate pharmaceutical equivalence and bioequivalence to the brand-name counterpart or the reference listed drug. This review discusses two important aspects of pharmaceutical equivalence for this synthetic peptide nasal spray product. The first aspect is drug substance sameness, in which a proposed generic salmon calcitonin product is required to demonstrate that it contain...

  3. Nasal septum perforation in patient with pyoderma gangrenosum

    OpenAIRE

    Maia, Camilla Bezerra da Cruz; Felix, Felippe; Paes, Vania; Azevedo, Julia Alves de; Grangeiro, Eliza Raquel Negrão; Riccio, Jonatah Lucas N.; Rito, Helen Cruz

    2012-01-01

    Summary Introduction: The cocaine is obtained from the leaves of the coca (Erythroxylon coca). It can be used in many ways, but the most common is the drug inhalation. The Cocaine also causes vasoconstriction at nasal mucous membrane and its chronic use can cause necrosis and nasal septum perforation. Pyoderma gangrenosum is an uncommon idiopathic disease characterized by ulcerations, usually observed on the legs. Its diagnosis is most common an exclusion of others diseases. So far, there is ...

  4. Strategie formulative per la veicolazione nasale di farmaci

    OpenAIRE

    Saladini, Bruno

    2014-01-01

    Microparticelle a base di complessi polielettrolitici di Chitosano/Pectina per il rilascio nasale di Tacrina cloridrato. Lo scopo di questo studio è stata la ricerca di nuove formulazioni solide per la somministrazione nasale di Tacrina cloridrato allo scopo di ridurre l’eccessivo effetto di primo passaggio epatico ed aumentarne la biodisponibilità a livello del Sistema Nervoso Centrale. La Tacrina è stata incapsulata in microparticelle mucoadesive a base di complessi elettrolitici di chitosa...

  5. Nasal heterotopia versus pilocytic astrocytoma: A narrow border.

    Science.gov (United States)

    Ellouze, N; Born, J; Hoyoux, C; Michotte, A; Retz, C; Tebache, M; Piette, C

    2015-08-01

    Failure of the anterior neuropore can lead to three main types of anomalies: nasal dermal sinus, encephalocele and nasal glioma or heterotopia. In this report, we describe a case of intracranial and extracranial glial heterotopia that probably resulted from a common failure of anterior neuropore development. We describe the prenatal radiological assessment based on ultrasound and MRI results, and consider their limitation for early fetal diagnosis. We also discuss the embryogenesis and the possible pathogenic mechanisms involved. PMID:26072230

  6. Treatment of Rhinitis Sicca Anterior with Ectoine Containing Nasal Spray

    Directory of Open Access Journals (Sweden)

    Uwe Sonnemann

    2014-01-01

    Full Text Available Objectives. The safety and efficacy of ectoine nasal spray and ectoine nasal spray with dexpanthenol in the treatment of rhinitis sicca were evaluated in two studies. Design and Methods. Two noninterventional observational studies were performed to evaluate the efficacy and safety of a nasal spray containing ectoine (study 1 and ectoine/dexpanthenol (study 2 over a period of two weeks including comparable numbers of patients suffering from rhinitis sicca anterior. Patients and physicians were asked to rate the efficacy in reducing symptoms and the tolerability over the treatment phase. Results. The treatment in both studies resulted in a clinical and statistical significant reduction of the main diagnosis parameters, nasal airway obstruction, and crust formation. There was also a significant reduction in the secondary diagnosis parameters in both studies. Importantly, the tolerability was very good. During the whole observational study, neither patients nor doctors stopped the medication due to unwanted effects. Conclusion. Rhinitis sicca could be successfully treated with a nasal spray containing ectoine and a nasal spray combining ectoine with dexpanthenol. The combination of both substances led to slight advantages.

  7. Trek1 contributes to maintaining nasal epithelial barrier integrity.

    Science.gov (United States)

    Jiang, Jing; Liu, Jiang-Qi; Li, Jing; Li, Meng; Chen, Hong-Bin; Yan, Hao; Mo, Li-Hua; Qiu, Shu-Qi; Liu, Zhi-Gang; Yang, Ping-Chang

    2015-01-01

    Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This study aims to elucidate the role of the TWIK-related potassium channel-1 (Trek1) in the regulation of the epithelial barrier function of the nasal mucosa. In this study, the levels of Trek1 were assessed by real time RT-PCR and Western blotting. The epithelial barrier function of the rat nasal epithelia was evaluated by the Ussing chamber system. The results showed that Trek1 was detected in the human and rat nasal epithelia, which were significantly lower in patients and rats with allergic rhinitis than that in healthy controls. Exposure to the signature T helper 2 cytokine, interleukin (IL)-4, markedly suppressed the expression of Trek1 in the nasal mucosa via up regulating the expression of the histone deacetylase (HDAC)1. The IL-4-induced rat nasal epithelial barrier dysfunction could be blocked by HDAC1 inhibitor (Trichostatin A), or sodium butyrate, or administration of Clostridium Butyricum. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function. PMID:25778785

  8. Nasal obstruction of the newborn: a differential diagnosis

    Directory of Open Access Journals (Sweden)

    Silva, Daniela Brunelli e

    2009-09-01

    Full Text Available Introduction: The nasal obstruction is potentially severe when affecting newborns, preferential nasal breathers. The newborns with nasal obstruction may present from an asymptomatic affection up to a severe situation of airway obstruction, with cyclical cyanosis. The cyanosis worsens with feeding and improves with crying. Despite the most common cause of obstruction in the newborn is mucosa edema secondary to viral rhinitis or idiopathic rhinitis of the child, it is important to be attentive to the diagnosis of the nasal anatomic alterations. Although not much frequent, they represent affections in which the early diagnosis and management are basic to prevent airway obstruction and feeding difficulties with recurrent aspiration. Objective: The objective of this case report is to describe the three most common causes of anatomic nasal obstruction in newborns: the choanal atresia, dacryocystocele and anterior piriform opening stenosis. Final Comments: The clinical characteristics, diagnostic investigation and treatment of these three pathologies are presented. Therefore, we seek to alert as to the importance that the nasal probe passage be part of the physical exam of every newborn, specially when it has breathing disorder upon birth and/or cyanosis when breastfeeding.

  9. Fibrosarcoma of the nasal cavity: A case report

    Directory of Open Access Journals (Sweden)

    Omar Maliki

    2014-11-01

    Full Text Available Nasal fibrosarcoma is an infrequent malignant neoplasm. It usually presents as other sarcomas in this region, with nasal obstruction and epistaxis. The final diagnosis is based on the histopathology and immunohistochemistry. We report the case of a 37-year-old man with a 3-month history of recurrent epistaxis and nasal obstruction. Nasal endoscopy confirmed a right nasal neoplasia. Computed tomography and magnetic resonance image showed the tumor. TEP scan showed no metastasis. Complete removal was achieved through a combined surgery, by endoscopic endonasal approach and by incision in the right upper oral vestibule. Fibrosarcoma was found on histopathologic and immunohistochemistric examinations. After 12 months, the postoperative course was uneventful and follow-up information showed no recurrence of metastasis. However, in the 13th month, the patient suddenly died at home. Autopsy found no obvious cause for his death. To the best of our knowledge, no case of a fibrosarcoma of the nasal cavity with sudden death has been previously reported in the English-language.

  10. Unstable Leidenfrost Drops on Roughened Surfaces

    CERN Document Server

    Boreyko, Jonathan B

    2010-01-01

    Drops placed on a surface with a temperature above the Leidenfrost point float atop an evaporative vapor layer. In this fluid dynamics video, it is shown that for roughened surfaces the Leidenfrost point depends on the drop size, which runs contrary to previous claims of size independence. The thickness of the vapor layer is known to increase with drop radius, suggesting that the surface roughness will not be able to penetrate the vapor layer for drops above a critical size. This size dependence was experimentally verified: at a given roughness and temperature, drops beneath a critical size exhibited transition boiling while drops above the critical size were in the Leidenfrost regime. These Leidenfrost drops were unstable; upon evaporation down to the critical size the vapor film suddenly collapsed.

  11. Nasalance and nasality at experimental velopharyngeal openings in palatal prosthesis: a case study

    Directory of Open Access Journals (Sweden)

    Aveliny Mantovan Lima-Gregio

    2011-12-01

    Full Text Available The use of prosthetic devices for correction of velopharyngeal insufficiency (VPI is an alternative treatment for patients with conditions that preclude surgery and for those individuals with a hypofunctional velopharynx (HV with a poor prognosis for the surgical repair of VPI. Understanding the role and measuring the outcome of prosthetic treatment of velopharyngeal dysfunction requires the use of tools that allow for documenting pre- and post-treatment outcomes. Experimental openings in speech bulbs have been used for simulating VPI in studies documenting changes in aerodynamic, acoustic and kinematics aspects of speech associated with the use of palatal prosthetic devices. The use of nasometry to document changes in speech associated with experimental openings in speech bulbs, however, has not been described in the literature. Objective: This single-subject study investigated nasalance and nasality at the presence of experimental openings drilled through the speech bulb of a patient with HV. Material and Methods: Nasometric recordings of the word "pato" were obtained under 4 velopharyngeal conditions: no-opening (control condition, no speech bulb, speech bulb with a 20 mm² opening, and speech bulb with 30 mm² opening. Five speech-language pathologists performed auditory-perceptual ratings while the subject read an oral passage under all conditions. Results: Kruskal-Wallis test showed significant difference among conditions (p=0.0002, with Scheffé post hoc test indicating difference from the no-opening condition. Conclusion: The changes in nasalance observed after drilling holes of known sizes in a speech bulb suggest that nasometry reflect changes in transfer of sound energy related to different sizes of velopharyngeal opening.

  12. [Plastic surgery indications for the repair of nasal tip and nasal alae defects].

    Science.gov (United States)

    Boudard, Ph

    2010-01-01

    Analyze methods of reconstruction of non-transfixing and transfixing loss of substance of the nasal tip and nasal ala. We would like to share the attitude guiding our selecting of the different methods to rehabilitate this mobile and functional portion of the nose. We retrospectively studied 32 cases of defects of the tip and ala treated between 2007 and 2009. There were 26 basal cell carcinomas, 5 squamous cell carcinomas and 1 melanoma. The minimum postoperative follow-up was one year. For reconstruction we used local flaps: medial dorsal flap, bilobed flap, transverse island flap and regional flaps: fronto-glabellar flap, forehead flap, nasolabial flap. In this study we analyzed the aesthetic and functional result achieved at the nasal orifice. We also studied the histopathological reports regarding safety tissue margins, both in depth and peripherally. Most of the defects of the tip and the alae of less than 1 cm were repaired by local flaps; bilobed or transverse island flaps. For the median region, the Rintala mid-dorsal flap appears to give better results. Tissue losses greater than 1 cm often required the use of a fronto-glabellar flap that allowed delivery of more tissue with less scarring at the donor site. The nasolabial flap may have the disadvantage of removing the crease and sometimes a certain thickness at the arc of rotation, which might require further thinning at a later stage. For transfixing loss of substance, we must repair all the layers: skin, cartilage and mucosa. The forehead flap with respect to the principles of the aesthetic subunits of the nose is the flap of choice. We stress on the importance of ample resection with adequate safety margins peripherally and in depth. PMID:21284228

  13. Linfoma nasal de células T/NK Nasal T/NK cell lymphoma

    Directory of Open Access Journals (Sweden)

    A. Torre Iturraspe

    2005-04-01

    Full Text Available El linfoma nasal de células T/ natural killer (NK (LNT/NK, tras haber recibido múltiples denominaciones, ha sido definido y caracterizado en el año 2001 por la Organización Mundial de la Salud (OMS, basándose en una clasificación previa de la Revised European-American Lymphoma Classification (REAL, de la manera en que se le conoce actualmente. Su incidencia en el mundo occidental es baja, mientras que en Asia supone el segundo grupo de linfomas más frecuente, tras los gastrointestinales. Se localiza preferentemente en las fosas nasales y senos maxilares, mostrando un curso clínico agresivo, definido por una destrucción de los tejidos circundantes. Su diagnóstico definitivo se realiza por medio de técnicas de hibridación in situ, llegando a la determinación de su inmunofenotipo. Se ha observado una frecuente asociación con el virus de Epstein-Barr (VEB. El pronóstico de esta enfermedad viene definido por el índice pronóstico internacional (IPI y por el volumen alcanzado por el tumor. A pesar de ser radiosensible, su pronóstico es infausto, aconteciendo la muerte del paciente poco tiempo después del diagnóstico, generalmente como consecuencia de las complicaciones del tratamiento.Nasal T-cell and Natural Killer cell lymphoma (NT/NKL, having been given many names, was defined and described in the year 2001 by the World Health Organization (WHO, on the basis of a previous classification by the Revised European-American Lymphoma Classification (REAL as it is known today. Its incidence in the western world is low, while in Asia it represents the second most frequent group of lymphomas, followed by the gastrointestinal [lymphoma]. It is typically located in the nasal cavity and maxillary sinuses. It is associated with an aggressive clinical course, characterized by the destruction of surrounding tissue. The definitive diagnosis is made by means of in situ hybridization techniques, in order to determine the immunophenotype. Its

  14. Clinical analysis of sino-nasal lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kojya, Shizuo; Itokazu, Tetsuo; Shinhama, Akihiko; Matsumura, Jun; Maeda, Hiroyuki; Inamine, Tomohiro; Toita, Takafumi; Ogawa, Kazuhiko; Noda, Yutaka [Ryukyus Univ., Nishihara, Okinawa (Japan). Faculty of Medicine

    2000-01-01

    Forty cases with sino-nasal malignant lymphoma who were treated at the Department of Otorhinolaryngology, University of the Ryukyus, Faculty of Medicine from 1974 to 1996 are herein reviewed. The staging of these cases was made based on the Ann Arbor classification system and pathologically according to the Working Formulation (WF). In addition, the lesions showed polymorphism regarding the size of the tumor cells which could invade in an angiocentric pattern with various types of inflammatory cells and necrosis of the surrounding tissue was classified as polymorphic reticulosis (PR). Regarding the immunological phenotype, immunostaining was performed with MB-1, L-26 for B cell type and MT-1, UCHL-1 for T cell type. The survival rate was calculated based on the Kaplan Meier method. The results were as follows; The immunophenotypes were T cell type in 63%, including 8 cases of NK cell type and B cell in 29%. Seventy-five percent of all cases were classified as an intermediate stage based on the Working Formulation. The 5-year survival rates for all cases, consisting of T cell type cases, B cell type cases and PR type cases were 49%, 42%, 50% and 54%, respectively. Chemotherapy, including CHOP demonstrated good therapeutic results, but the cases with lymphoma in the high grade group could not be controlled by ordinary therapeutic regimens. A histology-specific treatment regimen for high grade lymphoma is thus needed. (author)

  15. Nasal reconstruction based on aesthetic subunits in Orientals.

    Science.gov (United States)

    Yotsuyanagi, T; Yamashita, K; Urushidate, S; Yokoi, K; Sawada, Y

    2000-07-01

    Reconstruction based on the aesthetic subunit principle has yielded good aesthetic outcomes in patients with moderate to severe nasal defects caused by trauma or tumor resection. However, the topographic subunits previously proposed are often unsuitable for Orientals. Compared with the nose in white patients, the nose in Orientals is low, lacks nasal muscle, and has a flat glabella; the structural features of the underlying cartilage and bone are not distinctly reflected in outward appearance. The authors devised aesthetic subunits suitable for Orientals, and they used these units to reconstruct various parts of the nose. The major difference between these units and those presented previously is the lack of soft triangles and the addition of the glabella as an independent unit. The authors divided the nose into the following five topographic units: the glabella, the nasal dorsum, the nasal tip, and the two alae. The border of the nasal dorsum unit was extended to above the maxillonasal suture. The basic reconstruction techniques use a V-Y advancement flap from the forehead to reconstruct the glabella, an island flap from the forehead to reconstruct the nasal dorsum and nasal tip, a nasolabial flap to reconstruct an ala, and a malar flap to reconstruct the cheek. A combination of flaps was used when the defect involved more than one unit. This concept was used for nasal reconstruction in 24 patients. In one patient undergoing reconstruction of the nasal dorsum and in one undergoing reconstruction of the nasal tip, the texture of the forearm flap did not match well, which resulted in a slightly unsatisfactory aesthetic outcome. In one patient in whom the glabella, nasal dorsum, and part of the cheek were reconstructed simultaneously, a web was formed at the medial ocular angle, and a secondary operation was subsequently performed using Z-plasty. In one patient undergoing reconstruction with a forehead flap, defatting was required to reduce the bulk of the

  16. Nasal toxicity, carcinogenicity, and olfactory uptake of metals.

    Science.gov (United States)

    Sunderman, F W

    2001-01-01

    Occupational exposures to inhalation of certain metal dusts or aerosols can cause loss of olfactory acuity, atrophy of the nasal mucosa, mucosal ulcers, perforated nasal septum, or sinonasal cancer. Anosmia and hyposmia have been observed in workers exposed to Ni- or Cd-containing dusts in alkaline battery factories, nickel refineries, and cadmium industries. Ulcers of the nasal mucosa and perforated nasal septum have been reported in workers exposed to Cr(VI) in chromate production and chrome plating, or to As(III) in arsenic smelters. Atrophy of the olfactory epithelium has been observed in rodents following inhalation of NiSO4 or alphaNi3S2. Cancers of the nose and nasal sinuses have been reported in workers exposed to Ni compounds in nickel refining, cutlery factories, and alkaline battery manufacture, or to Cr(VI) in chromate production and chrome plating. In animals, several metals (eg, Al, Cd, Co, Hg, Mn, Ni, Zn) have been shown to pass via olfactory receptor neurons from the nasal lumen through the cribriform plate to the olfactory bulb. Some metals (eg, Mn, Ni, Zn) can cross synapses in the olfactory bulb and migrate via secondary olfactory neurons to distant nuclei of the brain. After nasal instillation of a metal-containing solution, transport of the metal via olfactory axons can occur rapidly, within hours or a few days (eg, Mn), or slowly over days or weeks (eg, Ni). The olfactory bulb tends to accumulate certain metals (eg, Al, Bi, Cu, Mn, Zn) with greater avidity than other regions of the brain. The molecular mechanisms responsible for metal translocation in olfactory neurons and deposition in the olfactory bulb are unclear, but complexation by metal-binding molecules such as carnosine (beta-alanyl-L-histidine) may be involved. PMID:11314863

  17. Sepsis from dropped clips at laparoscopic cholecystectomy

    International Nuclear Information System (INIS)

    We report seven patients in whom five dropped surgical clips and two gallstones were visualized in the peritoneal cavity, on radiological studies. In two, subphrenic abscesses and empyemas developed as a result of dropped clips into the peritoneal cavity during or following laparoscopic cholecystectomy. In one of these two, a clip was removed surgically from the site of an abscess. In two other patients dropped gallstones, and in three, dropped clips led to no complications. These were seen incidentally on studies done for other indications. Abdominal abscess secondary to dropped gallstones is a well-recognized complication of laparoscopic cholecystectomy (LC). We conclude that even though dropped surgical clips usually do not cause problems, they should be considered as a risk additional to other well-known causes of post-LC abdominal sepsis

  18. Pressure Drop Measurements on Distillation Columns

    Institute of Scientific and Technical Information of China (English)

    T.J. Cai; M.R. Resetarits

    2011-01-01

    Pressure drops are of major importance for distillation/absorption columns. This paper mainly discusses how to correctly measure, interpret and use pressure drop data. The possible causes of incorrect pressure drop measurements are studied including the effects of pressure tap dimensions, locations, and vapor condensation etc. The effect of the static head of vapor on the pressure drop data and column pressures is evaluated. Variations of sectional pressure drops along the column are investigated based on the experimental data obtained from commercial size distillation columns at Fractionation Research, Inc. (FRI). For a packed column, it is found that the spacing between the liquid distributor and the top of the bed affects the overall pressure drop measurements, which is confirmed by a fundamental fluid dynamics analysis.

  19. Condensation-induced jumping water drops

    OpenAIRE

    Narhe, R.D. (Ramchandra D.); Khandkar, M. D.; Shelke, P.B. (P. B.); Limaye, A. V.; Beysens, D.A. (Daniel A.)

    2009-01-01

    Water droplets can jump during vapor condensation on solid benzene near its melting point. This phenomenon, which can be viewed as a kind of micro scale steam engine, is studied experimentally and numerically. The latent heat of condensation transferred at the drop three phase contact line melts the substrate during a time proportional to R the drop radius . The wetting conditions change and a spontaneous jump of the drop results in random direction over length 1.5R, a phenomeno...

  20. Drops with non-circular footprints

    OpenAIRE

    Ravazzoli, Pablo D.; González, Alejandro G.; Diez, Javier A.

    2015-01-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. This type of drops is a consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to hysteresis effects of the contact angle since some parts of the contact line are wetting, while others are dewetting. Here, we obtain a peculiar drop shape from the rupture of a long liquid filament sitting ...

  1. Noncontact surface tension measurement by drop rotation

    OpenAIRE

    Rhim, Won-Kyu; Ishikawa, Takehiko

    2001-01-01

    Validity of the surface tension measurement technique that was proposed by Elleman et al. was experimentally verified. The technique was based on Brown and Scriven's work on the shape evolution of rotating drops. Molten tin and aluminum drops were levitated in high vacuum by the electrostatic levitator and rotated by applying a rotating magnetic field. This technique offers an alternative technique for those liquids where the drop oscillation technique cannot be used. As a demonstration, the ...

  2. Effects of nasal corticosteroids on boosts of systemic allergen-specific IgE production induced by nasal allergen exposure.

    Directory of Open Access Journals (Sweden)

    Cornelia Egger

    Full Text Available Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear.Here we aimed to determine in a double-blind, placebo-controlled study whether therapeutic doses of an INCS preparation, i.e., nasal fluticasone propionate, have effects on boosts of allergen-specific IgE following nasal allergen exposure.Subjects (n = 48 suffering from grass and birch pollen allergy were treated with daily fluticasone propionate or placebo nasal spray for four weeks. After two weeks of treatment, subjects underwent nasal provocation with either birch pollen allergen Bet v 1 or grass pollen allergen Phl p 5. Bet v 1 and Phl p 5-specific IgE, IgG1-4, IgM and IgA levels were measured in serum samples obtained at the time of provocation and one, two, four, six and eight weeks thereafter.Nasal allergen provocation induced a median increase to 141.1% of serum IgE levels to allergens used for provocation but not to control allergens 4 weeks after provocation. There were no significant differences regarding the boosts of allergen-specific IgE between INCS- and placebo-treated subjects.In conclusion, the application of fluticasone propionate had no significant effects on the boosts of systemic allergen-specific IgE production following nasal allergen exposure.http://clinicaltrials.gov/NCT00755066.

  3. Superheated water drops in hot oil

    OpenAIRE

    Soto, Enrique; Zenit, Roberto; Belmonte, Andrew

    2009-01-01

    Drops of water at room temperature were released in hot oil, which had a temperature higher than that of the boiling point of water. Initially, the drop temperature increases slowly mainly due to heat transfer diffusion; convective heat transfer is small because the motion takes place at a small Reynolds number. Once the drop reaches the bottom of the container, it sticks to the surface with a certain contact angle. Then, a part of the drop vaporizes: the nucleation point may appear at the wa...

  4. Videographic Assessment of Glaucoma Drop Instillation

    Science.gov (United States)

    Castillejos, Armando; Kahook, Malik; Jimenez-Roman, Jesus; Gonzalez-Salinas, Roberto

    2015-01-01

    ABSTRACT Purpose: To assess the effect of patient education on videotaped topical instillation of artificial tear drops on subsequent topical instillation. Materials and methods: Forty-five patients, who had been using glaucoma drops for at least 6 months and with a best-corrected visual acuity of 20/100 or better, were studied. The patients were asked to instill an artificial tear drop using their accustomed technique while being video recorded. The patients viewed the recordings, and the errors in their drop instillation method were pointed out. This was followed by an educational session on proper drop instillation technique. After 30 minutes, patients were videotaped instilling drops to ascertain the effect of the educational session. The variables compared were: number of drops instilled, number of drops reaching the ocular surface, and the number of times the tip of the medication bottle touched the eye or ocular adnexa. Results: Before the instruction session, patients squeezed an average of 1.5 ± 0.9 drops from the bottle, and the average number of drops reaching the conjunctival fornix was 0.9 ± 0.7. The tip of the bottle touched the ocular adnexa in 29/45 (64.4%) patients. After the education session, the patients squeezed an average of 1.2 ± 0.5 drops and an average of 1.2 ± 0.4 drops reached the conjunctival fornix. The tip of the bottle touched the ocular adnexa in 13/45 (28.9%) patients. With proper instructions, the percentage of patients that instilled just one drop on the eye increased from 66 to 82%. Conclusion: A single educational session on the proper use of topical drops improves the successful instillation of eye drops. However, it was not determined whether the patients will retain the improved instillation technique for long-term or if the intervention results in only a short-term improvement. How to cite this article: Lazcano-Gomez G, Castillejos A, Kahook M, Jimenez-Roman J, Gonzalez-Salinas R. Video-graphic Assessment of Glaucoma

  5. Parametric resonance in acoustically levitated water drops

    Energy Technology Data Exchange (ETDEWEB)

    Shen, C.L.; Xie, W.J. [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China); Wei, B., E-mail: bbwei@nwpu.edu.c [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2010-05-10

    Liquid drops can be suspended in air with acoustic levitation method. When the sound pressure is periodically modulated, the levitated drop is usually forced into an axisymmetric oscillation. However, a transition from axisymmetric oscillation into sectorial oscillation occurs when the modulation frequency approaches some specific values. The frequency of the sectorial oscillation is almost exactly half of the modulation frequency. It is demonstrated that this transition is induced by the parametric resonance of levitated drop. The natural frequency of sectorial oscillation is found to decrease with the increase of drop distortion extent.

  6. Drop deformation by laser-pulse impact

    CERN Document Server

    Gelderblom, Hanneke; Klein, Alexander L; Bouwhuis, Wilco; Lohse, Detlef; Villermaux, Emmanuel; Snoeijer, Jacco H

    2015-01-01

    A free-falling absorbing liquid drop hit by a nanosecond laser-pulse experiences a strong recoil-pressure kick. As a consequence, the drop propels forward and deforms into a thin sheet which eventually fragments. We study how the drop deformation depends on the pulse shape and drop properties. We first derive the velocity field inside the drop on the timescale of the pressure pulse, when the drop is still spherical. This yields the kinetic-energy partition inside the drop, which precisely measures the deformation rate with respect to the propulsion rate, before surface tension comes into play. On the timescale where surface tension is important the drop has evolved into a thin sheet. Its expansion dynamics is described with a slender-slope model, which uses the impulsive energy-partition as an initial condition. Completed with boundary integral simulations, this two-stage model explains the entire drop dynamics and its dependance on the pulse shape: for a given propulsion, a tightly focused pulse results in a...

  7. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  8. Infection in the Nasal Tip Caused by Acellular Dermal Matrix.

    Science.gov (United States)

    Lee, Kun Hee

    2015-12-01

    A 19-year-old female patient visited our clinic for rhinoplasty. She complained about her low take-off point, which was apparent in profile view, and wanted slight tip projection. She refused additional cartilage harvesting from ears or ribs but consented to the use of homologous tissue, including acellular dermal matrix, for her dorsum and tip. Septoturbinoplasty was performed, and only a very small amount of septal cartilage could be harvested. It was used as both the columellar strut and the alar rim graft. Nasal dorsum and tip were augmented with acellular dermal matrix. Three months postoperatively, she experienced a few episodes of edema and redness on her nasal tip, followed by pus exudation from the nasal skin. Six months postoperatively, she underwent revision rhinoplasty for removal of inflamed grafts, and onlay tip graft with homologous rib cartilage was performed. Nasal dorsum or tip grafts are an integral part of Asian rhinoplasty. Autogenous tissue is the gold standard for grafting materials. However, the limited availability of autogenous tissue and the preference of patients and surgeons for artificial surgical implants make Asian rhinoplasty challenging. Unavailability of autogenous cartilage and patient refusal of artificial implants led to the use of acellular dermal matrix (ADM) in the nasal dorsum and tip for this case. This is the first report of postoperative complication because of infection rather than absorption after ADM use. PMID:26894006

  9. Risk of contamination of nasal sprays in otolaryngologic practice

    Directory of Open Access Journals (Sweden)

    Akkuzu Babur

    2007-03-01

    Full Text Available Abstract Background Reusable nasal-spray devices are frequently used in otolaryngologic examinations, and there is an increasing concern about the risk of cross-contamination from these devices. The aim of our study was to determine, by means of microbiologic analysis, the safety of a positive-displacement or pump-type atomizer after multiple uses. Methods A reusable nasal spray bottle, pump, and tips were used in the nasal physical examination of 282 patients admitted to a tertiary otolaryngology clinic. The effectiveness of 2 different methods of prophylaxis against microbiologic contamination (the use of protective punched caps or rinsing the bottle tip with alcohol was compared with that of a control procedure. Results Although there was no statistically significant difference in positive culture rates among the types of nasal spray bottles tested, methicillin-resistant coagulase-negative staphylococci were isolated in 4 of 198 cultures. Conclusion Given these findings, we concluded that additional precautions (such as the use of an autoclave between sprays, disposable tips, or disposable devices are warranted to avoid interpatient cross-contamination from a reusable nasal spray device.

  10. [Arteriovenous anastomosis in nasal cavities using microcorrosion technique].

    Science.gov (United States)

    Passàli, D; Buccella, M G; Vetuschi, A; Bellussi, L

    1990-01-01

    In the present study the morphology of arteriovenous anastomoses in the nasal area are analyzed using the microcorrosion technique. This technique calls for perfusion of the vascular system, passing through the left ventricle, with Batson's of the vessels. For the first time in the microcorrosion study of the nasal vascular network human fetuses (from the 12th to 24th week of intrauterine life) obtained from spontaneous abortions were used as well as rats weighing from 250 to 300 gr. The animals were anesthetized with sodium thiopental prior to administration of the resin. A specimen containing the facial muscles, the nasal pyramid, the maxillary bone and the palatine bones was excised. Then, from this specimen the nasal septum and the two lateral portions of the nose were obtained. The bony and soft perivascular tissues were removed by placing the casts in an aqueous 20% KOH solution. Finally the corrosion cases were observed under a scanning electron microscope (EM). Within the nasal cavities the microcorrosion technique makes it possible to identify three different vascular layers: superficial, intermediate and deep. In the latter it proved possible to visualize the two types of arteriovenous anastomoses: i.e. simple and complex. On the basis of both vascular course and the impressions left by the endothelial cell nuclei it proved possible to differentiate between the arterial and venous portions of the anastomoses. PMID:2095105

  11. Optimization of Thermoreversible In Situ Nasal Gel of Timolol Maleate.

    Science.gov (United States)

    Jagdale, Swati; Shewale, Nirupama; Kuchekar, Bhanudas S

    2016-01-01

    Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. Timolol maleate is a beta blocker used primarily in the treatment of hypertension. Drug undergoes extensive hepatic first-pass metabolism (80%). The drug has half-life of 4 hrs. Oral bioavailability of timolol maleate is 61%. The aim of the present study was to optimize controlled release in situ nasal delivery for timolol maleate. HPMC and Poloxamer 407 were selected as polymer in formulation of thermoreversible in situ nasal gel. Optimization was carried out using 3(2) factorial design. It was observed that formulations f1 and f4 revealed the highest % drug release, that is, 93.57% and 91.66%, respectively. Factorial design study indicated that the drug release and viscosity were most significant dependent factors. Ex vivo diffusion study through nasal mucosa indicated 67.26 ± 2.10% and 61.07 ± 2.49% drug release for f1 and f4 formulations. f1 was the optimized batch. This batch thus can act as a potential nasal delivery with enhanced bioavailability for the drug. PMID:27293975

  12. Actual therapeutic management of allergic and hyperreactive nasal disorders

    Directory of Open Access Journals (Sweden)

    Rudack, Claudia

    2004-12-01

    Full Text Available Allergic rhinitis (AR and hyperractive disorders of the upper airways, depending upon the type of releasing stimuli, are defined as nasal hyperreactivity, for example in the case of AR, or as non-specific nasal hyperreactivity and as idiopathic rhinitis (IR (synonyms frequently used in the past: non-specific nasal hyperreactivity; vasomotor rhinitis in the case of non-characterised stimuli.An early and professional therapy of allergic disorders of the upper airways is of immense importance as allergic rhinitis is detected in comorbidities such as asthma and rhino sinusitis. The therapeutic concept is influenced by new and further developments in pharmacological substance classes such as antihistamines and glucocorticosteroids. Specific immune therapy, the only causal therapy for AR, has been reviewed over the past few years in respect of the type and pattern of application. However, to date no firm recommendations on oral, sublingual and /or nasal immune therapy have yet been drawn up based on investigations of these modifications.Therapeutic management of IR is aimed at a symptom-oriented therapy of nasal hyperactivity as etiological factors relating to this form of rhinitis are not yet sufficiently known. Drug groups such as mast cell stabilizers, systemic and topic antihistamines, topic and systemic glucocorticosteroids, ipatroium bromide and alpha symphatomimetics belong to the spectrum of the therapeutics employed.

  13. Optimization of Thermoreversible In Situ Nasal Gel of Timolol Maleate

    Directory of Open Access Journals (Sweden)

    Swati Jagdale

    2016-01-01

    Full Text Available Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. Timolol maleate is a beta blocker used primarily in the treatment of hypertension. Drug undergoes extensive hepatic first-pass metabolism (80%. The drug has half-life of 4 hrs. Oral bioavailability of timolol maleate is 61%. The aim of the present study was to optimize controlled release in situ nasal delivery for timolol maleate. HPMC and Poloxamer 407 were selected as polymer in formulation of thermoreversible in situ nasal gel. Optimization was carried out using 32 factorial design. It was observed that formulations f1 and f4 revealed the highest % drug release, that is, 93.57% and 91.66%, respectively. Factorial design study indicated that the drug release and viscosity were most significant dependent factors. Ex vivo diffusion study through nasal mucosa indicated 67.26 ± 2.10% and 61.07 ± 2.49% drug release for f1 and f4 formulations. f1 was the optimized batch. This batch thus can act as a potential nasal delivery with enhanced bioavailability for the drug.

  14. Rotating Drops with Helicoidal Symmetry

    CERN Document Server

    Palmer, Bennett

    2014-01-01

    See http://youtu.be/Mf4IE8gWcJs for a YouTube video showing part of the results in this paper. We consider helicoidal immersions in the Euclidean space whose axis of symmetry is the z-axis that are solutions of the equation 2 H=\\Lambda_0-a 1/2 R^2 where H is the mean curvature of the surface, R is the distance form the point in the surface to the z-axis and a is a real number. We refer to these surfaces as helicoidal rotating drops. We prove the existence of properly immersed solutions that contain the z-axis. We also show the existence of several families of embedded examples. We describe the set of possible solutions and we show that most of these solutions are not properly immerse and are dense in the region bounded by two concentric cylinders. We show that all properly immersed solutions, besides being invariant under a one parameter helicoidal group, they are invariant under a cyclic group of rotations of the variables x and y. The second variation of energy for the volume constrained problem with Dirich...

  15. Formulation and Evaluation of Nasal Niosomal in situ Gels of Loratadine

    Directory of Open Access Journals (Sweden)

    Vyshnavi. V

    2015-01-01

    Full Text Available Loratadine is an antihistaminic drug, used in the treatment of allergic inflammation. Poor bioavailability of the drug from conventional dosage forms is especially attributable to mucociliary clearance and transient residence time. These problems can be reduced by the employment of niosomal in situ gelling system. In situ gelling of niosomal drops was developed to maintain the drug localization for extended period of time. The niosomal in situ gel formulation was transformed into gel once it is instilled into the nasal cavity. Niosomes were formulated using various surfactants (span 20, 40, 60 and 80 in different ratios using thin film hydration technique. Niosomes were evaluated for particle size, drug entrapment efficiency and in-vitro drug release. Niosomes prepared using cholesterol and span 60 in the ratio 1:1 (F3 showed higher entrapment efficiency (94.87% and in-vitro drug release (59.90% was optimized. The optimized niosomes were developed into in situ gel (pH induced and thermoreversible. The gels were evaluated for gelling capability, pH, viscosity, drug content and in-vitro drug release. Ex-vivo permeation was performed for optimized in situ gels (G2 and T5. The flux (Jss and Permeability Coefficient (Kp was found to be higher for G2. Hence niosomal in situ gelling system may have its potential applications than the conventional nasal formulations and to improve the bioavailability of the drug through its longer residence time and ability to sustain drug release with minimal loss of drug.

  16. Nasal reflexes: implications for exercise, breathing, and sex.

    Science.gov (United States)

    Baraniuk, James N; Merck, Samantha J

    2008-04-01

    Nasal patency, with both congestion and decongestion, is affected in a wide variety of reflexes. Stimuli leading to nasal reflexes include exercise; alterations of body position, pressure, and temperature; neurologic syndromes; and dentistry. As anticipated, the vagal and trigeminal systems are closely integrated through nasobronchial and bronchonasal reflexes. However, perhaps of greater pathophysiologic importance are the naso-hypopharyngeal-laryngeal reflexes that become aggravated during sinusitis. None other than Sigmund Freud saw deeply beyond the facial adornment and recognized the deeper sexual tensions that can regulate nasal functions and psychoanalytical status. Wine, women, and song are linked with airflow through the nose-the nose, which by any other name would still smell as sweetly. PMID:18417057

  17. Formulation and evaluation of nasal mucoadhesive microspheres of sumatriptan succinate.

    Science.gov (United States)

    Jain, Snehal A; Chauk, Dheeraj S; Mahajan, Hitendra S; Tekade, Avinash R; Gattani, Surendra G

    2009-12-01

    The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing sumatriptan succinate (SS) were prepared by spray-drying technique. The microspheres were evaluated with respect to the yield, particle size, incorporation efficiency, swelling property, in vitro mucoadhesion, in vitro drug release, histological study and stability. Microspheres were characterized by differential scanning calorimetry, scanning electron microscopy and X-ray diffraction study. It was found that the particle size, swelling ability and incorporation efficiency of microspheres increases with increasing drug-to-polymer ratio. HPMC-based microspheres show adequate mucoadhesion and do not have any destructive effect on nasal mucosa. On the basis of these results, SS microspheres based on HPMC may be considered as a promising nasal delivery system. PMID:19888880

  18. Testing gene therapy vectors in human primary nasal epithelial cultures.

    Science.gov (United States)

    Cao, Huibi; Ouyang, Hong; Ip, Wan; Du, Kai; Duan, Wenming; Avolio, Julie; Wu, Jing; Duan, Cathleen; Yeger, Herman; Bear, Christine E; Gonska, Tanja; Hu, Jim; Moraes, Theo J

    2015-01-01

    Cystic fibrosis (CF) results from mutations in the CF transmembrane conductance regulator (CFTR) gene, which codes for a chloride/bicarbonate channel in the apical epithelial membranes. CFTR dysfunction results in a multisystem disease including the development of life limiting lung disease. The possibility of a cure for CF by replacing defective CFTR has led to different approaches for CF gene therapy; all of which ultimately have to be tested in preclinical model systems. Primary human nasal epithelial cultures (HNECs) derived from nasal turbinate brushing were used to test the efficiency of a helper-dependent adenoviral (HD-Ad) vector expressing CFTR. HD-Ad-CFTR transduction resulted in functional expression of CFTR at the apical membrane in nasal epithelial cells obtained from CF patients. These results suggest that HNECs can be used for preclinical testing of gene therapy vectors in CF. PMID:26730394

  19. Nasal PMN response to repeated challenge with endotoxin in healthy volunteers**

    Science.gov (United States)

    Abstract Rationale: We have employed nasal challenge with Iipopolysaccharid (lPS) followed by nasal lavage (NU to experimentally induce and examine upper airway inflammation in human volunteers.It is unclear however whether adaptation within individuals occurs following repeated ...

  20. The use of a camera-enabled mobile phone to triage patients with nasal bone injuries.

    LENUS (Irish Health Repository)

    Barghouthi, Taleb

    2012-03-01

    To identify the accuracy of a camera-enabled mobile phone in assessing patients with nasal bone injuries and to determine if treatment in the form of manipulation of the nasal bones and therefore outpatient attendance was necessary.

  1. Nasoendotracheal tube obstruction by a nasal polyp in emergency oral surgery: a case report

    OpenAIRE

    Milic Morena; Goranovic Tatjana; Knezevic Predrag

    2007-01-01

    Abstract Nasal polyps can make nasoendotracheal intubation difficult. We present a case of complete obstruction of a nasoendotracheal tube by a nasal polyp during a blind nasoendotracheal intubation in emergency oral surgery.

  2. Surfactant Proteins A, B, C and D in the Human Nasal Airway

    DEFF Research Database (Denmark)

    Gaunsbaek, Maria Q; Kjeldsen, Anette D; Svane-Knudsen, Viggo; Henriksen, Maiken L; Hansen, Soren

    2014-01-01

    Surgery, Odense University Hospital, Denmark. The study included 39 subjects. Nasal mucosal biopsies were analyzed by immunohistochemistry, and bronchoalveolar and nasal lavages, nasal brush biopsies and nasal mucus were analyzed for SP-A, -B, -C and -D by SDS-PAGE and Western blotting. The presence of SP-A...... and SP-D in the first three samplings were also analyzed by enzyme-linked immunosorbent assay. Results: In nasal mucosal biopsies, SP-A, -B, -C and -D were all demonstrated in the serous acini of the submucosal glands and in the surface epithelium. SP-D was detected in nasal brush biopsies, whereas...... the other SPs were absent. Moreover, SP-A, -B, -C and -D were absent in nasal lavage and mucus. Conclusion: SP-A, -B, -C and -D exert their protective effect in the ductal epithelium of the submucosal glands rather than in nasal secretions and mucus. Further studies are required to clarify the...

  3. Many Drops Make a Lake

    Directory of Open Access Journals (Sweden)

    Chaitanya S. Mudgal

    2014-03-01

    greater knowledge, better skills and disseminate this knowledge through this journal to influence as many physicians and their patients as possible. They have taken the knowledge of their teachers, recognized their giants and are now poised to see further than ever before. My grandmother often used to quote to me a proverb from India, which when translated literally means “Many drops make a lake”. I cannot help but be amazed by the striking similarities between the words of Newton and this Indian saying. Therefore, while it may seem intuitive, I think it must be stated that it is vital for the betterment of all our patients that we recognize our own personal lakes to put our drops of knowledge into. More important is that we recognize that it is incumbent upon each and every one of us to contribute to our collective lakes of knowledge such as ABJS. And finally and perhaps most importantly we need to be utterly cognizant of never letting such lakes of knowledge run dry.... ever.

  4. Comparison of nasal Midazolam with Ketamine versus nasal Midazolam as a premedication in children

    Directory of Open Access Journals (Sweden)

    Sonal S Khatavkar

    2014-01-01

    Full Text Available Background: T his study was done to compare effects of intranasal midazolam and intranasal midazolam with ketamine for premedication of children aged 1-12 yrs undergoing intermediate and major surgeries. Aims: Midazolam and Ketamine have already been used as premedicants in children. Our aim was to find out advantage of combination of midazolam with ketamine over midazolam by nasal route. Methods: Sixty children of age group 1-12 yrs of American Society of Anesthesiologists (ASA grade 1 and 2 were selected. Group A- midazolam (0.2 mg/kg, Group B- midazolam (0.15 mg/kg + ketamine 1 mg/kg. Both groups received drug intranasally 30 min before surgery in recovery room with monitored anesthesia care. Onset of sedation, sedation score, emotional reaction, intravenous cannula acceptance, and mask acceptance were studied. Statistical Analysis: Unpaired t test and chi square test. Results: Sedation score, anxiolysis, attitude, reaction to intravenous cannulation, face mask acceptance, and emotional reaction were significantly better in midazolam with ketamine group. Intra operatively, in both groups, pulse rate, oxygen saturation, and respiratory rate had no significant difference; also, post operatively, no significant difference was observed in above parameters, post operative analgesia was significantly better in midazolam with ketamine group. Conclusions: Intra nasal premedication allows rapid and predictable sedation in children. Midazolam as well as combination of Midazolam with ketamine gives good level of sedation and comfort. But quality of sedation, analgesia, and comfort is significantly better in midazolam with ketamine group. No significant side effects were observed in both groups.

  5. Detecting Nasal Vowels in Speech Interfaces Based on Surface Electromyography.

    Directory of Open Access Journals (Sweden)

    João Freitas

    Full Text Available Nasality is a very important characteristic of several languages, European Portuguese being one of them. This paper addresses the challenge of nasality detection in surface electromyography (EMG based speech interfaces. We explore the existence of useful information about the velum movement and also assess if muscles deeper down in the face and neck region can be measured using surface electrodes, and the best electrode location to do so. The procedure we adopted uses Real-Time Magnetic Resonance Imaging (RT-MRI, collected from a set of speakers, providing a method to interpret EMG data. By ensuring compatible data recording conditions, and proper time alignment between the EMG and the RT-MRI data, we are able to accurately estimate the time when the velum moves and the type of movement when a nasal vowel occurs. The combination of these two sources revealed interesting and distinct characteristics in the EMG signal when a nasal vowel is uttered, which motivated a classification experiment. Overall results of this experiment provide evidence that it is possible to detect velum movement using sensors positioned below the ear, between mastoid process and the mandible, in the upper neck region. In a frame-based classification scenario, error rates as low as 32.5% for all speakers and 23.4% for the best speaker have been achieved, for nasal vowel detection. This outcome stands as an encouraging result, fostering the grounds for deeper exploration of the proposed approach as a promising route to the development of an EMG-based speech interface for languages with strong nasal characteristics.

  6. Assessment of nasal patency after rhinoplasty through the Glatzel mirror

    Directory of Open Access Journals (Sweden)

    Pochat, Victor Diniz de

    2012-01-01

    Full Text Available Introduction: Objective evaluation of nasal function is a constant challenge for plastic surgeons, otolaryngologists, and allergists. The modified Glatzel mirror can evaluate nasal expiratory flow; however, there is little information on this method and its use in the measurement of nasal patency after surgical procedures. Objective: To compare, in a prospective study, the functional results before and after cosmetic rhinoplasty and evaluate the use of the Glatzel mirror as an objective method to assess nasal patency. Methods: To achieve this objective, we analyzed the functional results of surgery through a subjective questionnaire and objective evaluation through a modified Glatzel mirror, and evaluated the correlation between the 2 methods. Twenty patients (14 women and 6 men underwent aesthetic rhinoplasty using spreader grafts. Pre- and postoperative evaluation (90-120 days included a respiratory quality score (subjective and modified Glatzel mirror test (objective. Subsequently, the Spearman test was used to compare the pre- and postoperative subjective and objective data. Results: The subjective evaluation demonstrated a statistical difference between pre- and postoperative scores (8 ± 2 and 9.4 ± 0.7, P< 0.001. There was no statistical difference in mean nasal patency by modified Glatzel mirror. No statistically significant correlation was observed when comparing the modified Glatzel mirror values with the subjective scores reported by patients pre- or postoperatively. Conclusion: The Glatzel method lacks sensitivity in detecting patient-reported improvements in breathing following rhinoplasty. This suggests that the method is a poor assessment tool to detect small, post-surgical changes in the nasal airways.

  7. Nasal polyps with metaplastic ossification: CT and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yi Kyung; Kim, Hyung-Jin; Kim, Eunhee; Kim, Sung Tae [Sungkyunkwan University School of Medicine, Department of Radiology, Samsung Medical Center, Seoul (Korea, Republic of); Kim, Jinna [Yonsei University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Chung, Seung-Kyu [Sungkyunkwan University School of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Seoul (Korea, Republic of); Ko, Young-Hyeh [Sungkyunkwan University School of Medicine, Department of Pathology, Samsung Medical Center, Seoul (Korea, Republic of)

    2010-12-15

    Metaplastic ossification is a rare event in nasal polyps. The purpose of this study was to review the computed tomography (CT) and magnetic resonance (MR) imaging findings of nasal polyps with metaplastic ossification. CT (n = 5) and MR (n = 3) images of five patients (four men and one woman; mean age, 59 years) with surgically proven nasal polyp with metaplastic ossification were retrospectively reviewed. The location and morphologic characteristics of metaplastic ossification were documented as well. All lesions were seen as lobulated (n = 3), ovoid (n = 1), or dumbbell-shaped (n = 1) benign-looking masses with a mean size of 3.7 cm (range, 2.4-6.5 cm), located unilaterally in the posterior nasal cavity and nasopharynx (n = 2), posterior nasoethmoidal tract (n = 2), and maxillary sinus and nasal cavity (n = 1). Compared with the brain stem, the soft tissue components of all lesions demonstrated isoattenuation on precontrast CT scans, slight hypointensity on T1-weighted MR images, and hyperintensity on T2-weighted MR images. On contrast-enhanced MR images, heterogeneous enhancement with marked peripheral enhancement was seen in two and homogeneous moderate enhancement in one. All lesions contained centrally located radiodense materials on CT scans, the shape of which was multiple clustered in three, single nodular in one, and single large lobulated in one. Although rare, metaplastic ossification can occur within nasal polyps. The possibility of its diagnosis may be raised when one sees a benign-looking sinonasal mass with centrally located radiodense materials on CT scans. MR imaging may be useful when mycetoma or inverted papilloma cannot be ruled out on CT scans. (orig.)

  8. Equilibrium shapes of a ferrofluid drop

    OpenAIRE

    Lavrova, O.; Polevikov, V.; Tobiska, L.

    2005-01-01

    A numerical solution strategy for calculating equilibrium free surfaces of a ferrofluid drop under the action of uniform magnetic fields is proposed. Based on this strategy, drop shapes of nonlinear magnetizable fluids are obtained numerically in a wide range of field intensities and compared with existing theoretical results

  9. 49 CFR 178.603 - Drop test.

    Science.gov (United States)

    2010-10-01

    ... qualification of all packaging design types and performed periodically as specified in § 178.601(e). For other than flat drops, the center of gravity of the test packaging must be vertically over the point of... result in failure of the packaging must be used. The number of drops required and the...

  10. Mixing in colliding, ultrasonically levitated drops.

    Science.gov (United States)

    Chainani, Edward T; Choi, Woo-Hyuck; Ngo, Khanh T; Scheeline, Alexander

    2014-02-18

    Lab-in-a-drop, using ultrasonic levitation, has been actively investigated for the last two decades. Benefits include lack of contact between solutions and an apparatus and a lack of sample cross-contamination. Understanding and controlling mixing in the levitated drop is necessary for using an acoustically levitated drop as a microreactor, particularly for studying kinetics. A pulsed electrostatic delivery system enables addition and mixing of a desired-volume droplet with the levitated drop. Measurement of mixing kinetics is obtained by high-speed video monitoring of a titration reaction. Drop heterogeneity is visualized as 370 nl of 0.25 M KOH (pH: 13.4) was added to 3.7 μL of 0.058 M HCl (pH: 1.24). Spontaneous mixing time is about 2 s. Following droplet impact, the mixed drop orbits the levitator axis at about 5 Hz during homogenization. The video's green channel (maximum response near 540 nm) shows the color change due to phenolphthalein absorption. While mixing is at least an order of magnitude faster in the levitated drop compared with three-dimensional diffusion, modulation of the acoustic waveform near the surface acoustic wave resonance frequency of the levitated drop does not substantially reduce mixing time. PMID:24460103

  11. Aging, Terminal Decline, and Terminal Drop

    Science.gov (United States)

    Palmore, Erdman; Cleveland, William

    1976-01-01

    Data from a 20-year longitudinal study of persons over 60 were analyzed by step-wise multiple regression to test for declines in function with age, for terminal decline (linear relationship to time before death), and for terminal drop (curvilinear relationship to time before death). There were no substantial terminal drop effects. (Author)

  12. University Drop-Out: An Italian Experience

    Science.gov (United States)

    Belloc, Filippo; Maruotti, Antonello; Petrella, Lea

    2010-01-01

    University students' drop-out is a crucial issue for the universities' efficiency evaluation and funding. In this paper, we analyze the drop-out rate of the Economics and Business faculty of Sapienza University of Rome. We use administrative data on 9,725 undergraduates students enrolled in three-years bachelor programs from 2001 to 2007 and…

  13. Diffusion-driven evaporation of sessile drops

    International Nuclear Information System (INIS)

    The evaporation of wetting drops deposited on a substrate at thermal equilibrium under normal atmosphere is discussed. The evaporation rate appears to be controlled by the stationary diffusion of vapour molecules in the gas phase. Experiments with alkanes and water drops are fairly well accounted for by an isothermal model, taking into account the specific properties of thin films

  14. Electrical Excitation of Water Drops in Oil

    OpenAIRE

    Penne, Torstein Eidsnes

    2015-01-01

    Water drops in oil are excited by the use of electric fields. This thesis looks at the behavior of water drops subjected to different fields. These fields vary in shape and strength. The motivation behind is separation of oil and water after oil extraction with water injection, by using electric fields for electrocoalescence.

  15. Nasal vascularization: experiences using the microcorrosion technique in human foetuses.

    Science.gov (United States)

    Passàli, D; Buccella, M G; Vetuschi, A; Bellussi, L

    1992-06-01

    The authors have studied the three-dimensional aspect of the vascular architecture of the nasal mucosa, using the microcorrosion method followed by scanning electron microscopical observation of casts of the vascular networks in both the septum and the lateral part of the nose. Batson's compound was introduced into the vascular system through the ascending aorta, in order to obtain a replica of the nasal mucosa vessels. Twelve- to 24-week-old foetuses obtained from spontaneous abortions were used for this purpose. PMID:1411101

  16. Metabolism of ferrocene by rat nasal and liver microsomes

    International Nuclear Information System (INIS)

    Toxicokinetics from earlier studies suggested that there Is high ferrocene hydroxylase activity in nasal tissue. We developed an assay using 59Fe-labeled ferrocene to confirm that nasal tissue, in particular olfactory tissue, has ferrocene hydroxylase activity exceeding that of liver by about a factor of ten. Because metabolism of ferrocene potentially leads to iron-catalyzed peroxidation, it was predicted that the olfactory tissue would be especially sensitive to toxic effects from inhaled ferrocene. This was confirmed in an independent study. (author)

  17. Hydrothermal waves in evaporating sessile drops

    CERN Document Server

    Brutin, D; Niliot, C Le

    2009-01-01

    Drop evaporation is a simple phenomena but still unclear concerning the mechanisms of evaporation. A common agreement of the scientific community based on experimental and numerical work evidences that most of the evaporation occurs at the triple line. However, the rate of evaporation is still empirically predicted due to the lack of knowledge on the convection cells which develop inside the drop under evaporation. The evaporation of sessile drop is more complicated than it appears due to the coupling by conduction with the heating substrate, the convection and conduction inside the drop and the convection and diffusion with the vapour phase. The coupling of heat transfer in the three phases induces complicated cases to solve even for numerical simulations. We present recent experimental fluid dynamics videos obtained using a FLIR SC-6000 coupled with a microscopic lens of 10 micron of resolution to observe the evaporation of sessile drops in infrared wavelengths. The range of 3 to 5 micron is adapted to the ...

  18. Temperature Effect on Photovoltaic Modules Power Drop

    Directory of Open Access Journals (Sweden)

    Qais Mohammed Aish

    2015-06-01

    Full Text Available In order to determine what type of photovoltaic solar module could best be used in a thermoelectric photovoltaic power generation. Changing in powers due to higher temperatures (25oC, 35oC, and 45oC have been done for three types of solar modules: monocrystalline , polycrystalline, and copper indium gallium (di selenide (CIGS. The Prova 200 solar panel analyzer is used for the professional testing of three solar modules at different ambient temperatures; 25oC, 35oC, and 45oC and solar radiation range 100-1000 W/m2. Copper indium gallium (di selenide module has the lowest power drop (with the average percentage power drop 0.38%/oC while monocrystalline module has the highest power drop (with the average percentage power drop 0.54%/oC, while polycrystalline module has a percentage power drop of 0.49%/oC.

  19. CPAS Preflight Drop Test Analysis Process

    Science.gov (United States)

    Englert, Megan E.; Bledsoe, Kristin J.; Romero, Leah M.

    2015-01-01

    Throughout the Capsule Parachute Assembly System (CPAS) drop test program, the CPAS Analysis Team has developed a simulation and analysis process to support drop test planning and execution. This process includes multiple phases focused on developing test simulations and communicating results to all groups involved in the drop test. CPAS Engineering Development Unit (EDU) series drop test planning begins with the development of a basic operational concept for each test. Trajectory simulation tools include the Flight Analysis and Simulation Tool (FAST) for single bodies, and the Automatic Dynamic Analysis of Mechanical Systems (ADAMS) simulation for the mated vehicle. Results are communicated to the team at the Test Configuration Review (TCR) and Test Readiness Review (TRR), as well as at Analysis Integrated Product Team (IPT) meetings in earlier and intermediate phases of the pre-test planning. The ability to plan and communicate efficiently with rapidly changing objectives and tight schedule constraints is a necessity for safe and successful drop tests.

  20. Ferrofluid drops in rotating magnetic fields

    CERN Document Server

    Lebedev, A V; Morozov, K I; Bauke, H

    2003-01-01

    Drops of a ferrofluid floating in a non-magnetic liquid of the same density and spun by a rotating magnetic field are investigated experimentally and theoretically. The parameters for the experiment are chosen such that different stationary drop shapes including non-axis-symmetric configurations could be observed. Within an approximate theoretical analysis the character of the occurring shape bifurcations, the different stationary drop forms, as well as the slow rotational motion of the drop is investigated. The results are in qualitative, and often quantitative agreement, with the experimental findings. It is also shown that a small eccentricity of the rotating field may have a substantial impact on the rotational motion of the drop.

  1. Method for making nasal bone roentgenograms for the diagnosis of fractures

    International Nuclear Information System (INIS)

    The author suggests a method for making highly-structured roentgenograms of nasal bones in forensic medical expert examinations of live subjects, involving no x-raying of nasal bones. The method is based on nasal bones imaging in skull bone roentgenography in the lateral projection

  2. Acute effects of nasal salmon calcitonin on calcium and bone metabolism

    DEFF Research Database (Denmark)

    Thamsborg, G; Skousgaard, S G; Daugaard, H; Schifter, S; Kollerup, G; Sørensen, O H

    1993-01-01

    .5) nmol/mmol to 11.7 (3.2) nmol/mmol after nasal SCT (P = 0.04). Nasal SCT did not change the serum levels of alkaline phosphatase, osteocalcin, and the carboxyterminal propeptide of type 1 procollagen. The results indicate that nasal SCT given as a single dose provokes a modest decrease in bone...

  3. STUDY OF NASAL INDEX AMONG STUDENTS OF TERTIARY MEDICAL CARE INSTITUTE IN SOUTHERN INDIA

    Directory of Open Access Journals (Sweden)

    Asharani S K

    2015-12-01

    Full Text Available Background: India is an ancient country having a diverse population group of various races, ethnic groups and tribes living in different climatic conditions. Nasal index is an ethnic sensitive anthropometric index which is used to classify race and sex of an individual. Aim: To study the Nasal index by using nasal parameters like Nasal height and Nasal width among students of South India and North India. Materials and Method: The study was done on medical students (male and female aged between 18-23yrs of age after obtaining the necessary consent. Nasal height and nasal width were measured with the aid of sliding caliper. On the basis of nasal height and nasal width, nasal index was calculated and the data was analyzed statistically. Results: The present study revealed that majority of the Indian population (both South India and North India belong to mesorrhinae type of nasal form followed by platyrrhinae and leptorrhinae. Conclusion: The majority of the Indian population belongs to mesorrhinae type of nasal form. The particular data will be of importance in forensic science, anthropology and rhinoplasty.

  4. Lesao nasal precoce pelo uso da pronga nasal em recem-nascidos prematuros de muito baixo peso: estudo piloto

    Directory of Open Access Journals (Sweden)

    Nathalie Tiemi Ota

    2013-09-01

    Full Text Available OBJETIVO: Analisar, em recém-nascidos de muito baixo peso e com indicação de ventilação não invasiva via pronga nasal, a incidência do aparecimento precoce de lesão nasal. MÉTODOS: Série de casos prospectiva de nascidos com idade gestacional <37 semanas, peso <1.500g e idade pós-natal <29 dias. Os pacientes foram avaliados desde a instalação da pronga nasal até o 3o dia de uso, três vezes ao dia. Foram analisadas as condições clínicas dos pacientes, características do dispositivo e de sua aplicação. A análise inicial foi descritiva, verificando-se a prevalência de lesão nasal bem como os fatores a ela associados. Os dados categóricos foram analisados por qui-quadrado ou exato de Fisher e os dados numéricos, por teste t ou Mann-Whitney. RESULTADOS: Dezoito recém-nascidos foram incluídos, dos quais 12 (idade gestacional de 29,8±3,1 semanas, peso ao nascer de 1.070±194g e Score for Neonatal Acute Phisiology - Perinatal Extension (SNAPPE de 15,4±17,5 evoluíram com lesão nasal (Grupo Lesão e 6 (idade gestacional de 28,0±1,9 semanas, peso de 1.003±317g e SNAPPE de 26,2±7,5 não apresentaram lesão nasal (Grupo Sem Lesão. No Grupo Lesão, houve maior frequência do gênero masculino (75% versus 17%, a lesão apareceu em média após 18 horas e predominantemente no período notur no (75%. CONCLUSÃO: A incidência de lesão nasal em prematuros submetidos à ventilação não invasiva via pronga nasal foi elevada, sendo possível planejar estudo dos fatores associados, com base neste piloto.

  5. Efeito do exercício físico sobre o volume nasal Effects of physical exercise in nasal volume

    Directory of Open Access Journals (Sweden)

    Marconi Teixeira Fonseca

    2006-04-01

    Full Text Available A variação da permeabilidade nasal tem sido demonstrada usando-se várias técnicas de exame. As estruturas nasais geram uma resistência que representa cerca de 50% da resistência respiratória total. O exercício físico é um dos fatores que pode causar um efeito vasoconstritor sobre a mucosa nasal. OBJETIVO: O objetivo deste estudo é avaliar o grau de mudança do volume nasal após exercício físico e o tempo de retorno aos níveis basais. MATERIAIS E MÉTODOS: Dezenove indivíduos foram submetidos à realização de teste físico em bicicleta ergométrica. O volume nasal foi obtido através da rinometria acústica, realizada em repouso, após o fim do exercício físico, e nos minutos décimo e vigésimo de seu final. RESULTADOS: Os resultados rinométricos mostram um aumento estatisticamente significativo do volume nasal (p The nasal permeability has been demonstrated using several exams. Nasal structures produces a resistance to the nasal air flux that represents over 50% of the total respiratory resistance. Physical exercises is a factor that brings a vasoconstrictor effect over nasal mucosa. AINS: Evaluate the improvement degree of nasal volume after aerobic physical exercises and time to return to previous levels. SUBJECTS AND METHODS: Nineteen heathly subjects were submitted to aerobic exercise in ergometric bike. The nasal volume was obtained by Acoustic Rhinometry perfomed in rest, after aerobic exercise, 10o and 20o minutes after the aerobic exercise. RESULTS: Rhynometrics results shows a statically and significant increase of nasal volume (p<0,001. The nasal volume, in twenty minutes, returns nearby the rest levels. CONCLUSIONS: Aerobic exercises, generally, increases the nasal volume. However, the increase of nasal volume was transitory, and occurs a major reduction of increase in the first ten minutes after the exercises ends, and perform a greater vasoconstrictor effect over nasal mucosa, Twenty minutes after the physical

  6. Superheated water drops in hot oil

    CERN Document Server

    Soto, Enrique; Belmonte, Andrew

    2009-01-01

    Drops of water at room temperature were released in hot oil, which had a temperature higher than that of the boiling point of water. Initially, the drop temperature increases slowly mainly due to heat transfer diffusion; convective heat transfer is small because the motion takes place at a small Reynolds number. Once the drop reaches the bottom of the container, it sticks to the surface with a certain contact angle. Then, a part of the drop vaporizes: the nucleation point may appear at the wall, the interface or the bulk of the drop. The vapor expands inside the drop and deforms its interface. The way in which the vapor expands, either smooth or violent, depends on the location of the nucleation point and oil temperature. Furthermore, for temperatures close to the boiling point of water, the drops are stable (overheated); the vaporization does not occur spontaneously but it may be triggered with an external perturbation. In this case the growth of the vapor bubble is rather violent. Many visualization for dif...

  7. Leidenfrost drops on a heated liquid pool

    CERN Document Server

    Maquet, Laurent; Darbois-Texier, Baptiste; Brandenbourger, Martin; Rednikov, Alexey; Colinet, Pierre; Dorbolo, Stéphane

    2016-01-01

    We show that a volatile liquid drop placed at the surface of a non-volatile liquid pool warmer than the boiling point of the drop can experience a Leidenfrost effect even for vanishingly small superheats. Such an observation points to the importance of the substrate roughness, negligible in the case considered here, in determining the threshold Leidenfrost temperature. A theoretical model based on the one proposed by Sobac et al. [Phys. Rev. E 90, 053011 (2014)] is developed in order to rationalize the experimental data. The shapes of the drop and of the substrate are analyzed. The model notably provides scalings for the vapor film thickness. For small drops, these scalings appear to be identical to the case of a Leidenfrost drop on a solid substrate. For large drops, in contrast, they are different and no evidence of chimney formation has been observed either experimentally or theoretically in the range of drop sizes considered in this study. Concerning the evaporation dynamics, the radius is shown to decrea...

  8. Drop impact splashing and air entrapment

    KAUST Repository

    Thoraval, Marie-Jean

    2013-03-01

    Drop impact is a canonical problem in fluid mechanics, with numerous applications in industrial as well as natural phenomena. The extremely simple initial configuration of the experiment can produce a very large variety of fast and complex dynamics. Scientific progress was made in parallel with major improvements in imaging and computational technologies. Most recently, high-speed imaging video cameras have opened the exploration of new phenomena occurring at the micro-second scale, and parallel computing allowed realistic direct numerical simulations of drop impacts. We combine these tools to bring a new understanding of two fundamental aspects of drop impacts: splashing and air entrapment. The early dynamics of a drop impacting on a liquid pool at high velocity produces an ejecta sheet, emerging horizontally in the neck between the drop and the pool. We show how the interaction of this thin liquid sheet with the air, the drop or the pool, can produce micro-droplets and bubble rings. Then we detail how the breakup of the air film stretched between the drop and the pool for lower impact velocities can produce a myriad of micro-bubbles.

  9. Drop on demand in a microfluidic chip

    International Nuclear Information System (INIS)

    In this work, we introduce the novel technique of in-chip drop on demand, which consists in dispensing picoliter to nanoliter drops on demand directly in the liquid-filled channels of a polymer microfluidic chip, at frequencies up to 2.5 kHz and with precise volume control. The technique involves a PDMS chip with one or several microliter-size chambers driven by piezoelectric actuators. Individual aqueous microdrops are dispensed from the chamber to a main transport channel filled with an immiscible fluid, in a process analogous to atmospheric drop on demand dispensing. In this paper, the drop formation process is characterized with respect to critical dispense parameters such as the shape and duration of the driving pulse, and the size of both the fluid chamber and the nozzle. Several features of the in-chip drop on demand technique with direct relevance to lab-on-a-chip applications are presented and discussed, such as the precise control of the dispensed volume, the ability to merge drops of different reagents and the ability to move a drop from the shooting area of one nozzle to another for multistep reactions. The possibility to drive the microfluidic chip with inexpensive audio electronics instead of research-grade equipment is also examined and verified. Finally, we show that the same piezoelectric technique can be used to generate a single gas bubble on demand in a microfluidic chip

  10. Terminal Effect of Drop Coalescence on Single Drop Mass Transfer Measurements and Its Minimization

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    For the mass transfer to single drops during the stage of steady buoyancy-driven motion, experimental measurement is complicated with the terminal effect of additional mass transfer during drop formation and coa lescence at the drop collector. Analysis reveals that consistent operating conditions and experimental procedure are of critical significance for minimizing the terminal effect of drop coalescence on the accuracy of mass transfer measurements. The novel design of a totally-closed extraction column is proposed for this purpose, which guaran tees that the volumetric rate of drop phase injection is exactly equal to that of withdrawal of drops. Tests in two extraction systems demonstrate that the experimental repeatability is improved greatly and the terminal effect of mass transfer during drop coalescence is brought well under control.

  11. Effect of sleeping position on nasal patency in newborns

    OpenAIRE

    Olarinde, O; Banerjee, A R; O'Callaghan, C

    2006-01-01

    Sleeping posture has been implicated in the pathophysiology of sudden infant death syndrome. The effect of supine and lateral sleeping positions on nasal patency was investigated using acoustic rhinometry in 11 healthy newborns. The implications of the findings in sudden infant death syndrome are discussed.

  12. The Fungi Flora of Healthy Nasal Mucosa in Kerman, Iran

    Directory of Open Access Journals (Sweden)

    Narges Khanjani

    2011-04-01

    Full Text Available Introduction: Environmental fungi, molds and yeasts, can infest the nasal cavity through inhaled air. There is some evidence that they could be the main cause of Chronic Rhinosinusitis (CRS but little is known about the normal fungal flora in the human nose. The objective of this study was to assess the normal fungal flora of the nasal mucus in adults in Kerman. Materials and Methods: We conducted a cross sectional study. Nasal swabs were used to sample the nasal cavity of 100 adults, 46 men and 54 women between 17 and 60 years old, currently living in Kerman, Iran. Results: Among 100 healthy people, one or more types of fungi were detected in 31 (31% persons; Candida in 12 persons, Aspergillus in 8 persons, Streptomyces in 8 persons, and Penicillium, Nocardia and Mucor in a few persons. In only 4 persons, more than one type of fungi was detected.  There was no significant relation between age, sex, education or smoking with the presence of fungi. Conclusion: Fungi have been considered one of the causative agents of CRS and differences in climatic conditions can influence the fungi flora.

  13. A modified bilobed flap design for nasal tip defects

    Directory of Open Access Journals (Sweden)

    Zhi-Guo Wang

    2014-06-01

    Full Text Available Aim: The correction of nasal tip defects presents many challenges. Zitelli's bilobed flap has been widely used for such repairing defects, but may be complicated by interrupted scars on the nasal dorsum. Our study evaluates the design principles, results, and advantages of a modified bilobed flap for repairing nasal tip defects. Methods: The primary lobe was located between the defect and the cheek, and the second lobe was located in the cheek. The width of the primary lobe was equal to that of the primary defect. The length of the primary lobe was 10% longer than the distance of the distal defect edge to the pivot point of the flap. The length of the second lobe was 30% longer than the distance of the distal defect edge to the pivot point of the flap. The width of the second lobe was 90%-100% of that of the primary lobe. The ability to close the defect under minimal tension, the cosmetic appearance, and any complications were evaluated. Results: This technique was performed in 34 cases; defect size ranged from 0.8 cm × 0.9 cm to 1.2 cm × 1.8 cm. All defects were closed under minimal wound tension, all scars were inconspicuous, no obvious complications occurred, and the aesthetic outcomes were considered favorable. Conclusion: The modified bilobed flap can provide satisfying outcomes with lower morbidity and inconspicuous scarring. It is simple and suitable for repairing small- to medium-sized defects in the nasal tip.

  14. High flow nasal cannula for respiratory support in preterm infants.

    LENUS (Irish Health Repository)

    Wilkinson, Dominic

    2011-01-01

    High flow nasal cannulae (HFNC) are small, thin, tapered cannulae used to deliver oxygen or blended oxygen and air at flow rates of > 1 L\\/min. HFNC can be used to provide high concentrations of oxygen and may deliver positive end-expiratory pressure.

  15. Nasal versus temporal preretinal vasoproliferation in retinopathy of prematurity.

    OpenAIRE

    Nissenkorn, I; Kremer, I; Cohen, S.; Ben-Sira, I

    1989-01-01

    Nasal preretinal neovascularisations have been observed to develop at least two weeks earlier than those on the temporal side in more than a third of premature babies with retinopathy of prematurity (ROP) stage 3, weighing between 690 and 1030 g. All these babies were assigned for cryotherapy. This interesting observation is discussed in relation to retinal vascular development and the pathogenesis of ROP.

  16. Nasal and Oral Inspiration during Natural Speech Breathing

    Science.gov (United States)

    Lester, Rosemary A.; Hoit, Jeannette D.

    2014-01-01

    Purpose: The purpose of this study was to determine the typical pattern for inspiration during speech breathing in healthy adults, as well as the factors that might influence it. Method: Ten healthy adults, 18-45 years of age, performed a variety of speaking tasks while nasal ram pressure, audio, and video recordings were obtained. Inspirations…

  17. Chrome induced nasal septal perforation-An occupational hazard

    OpenAIRE

    Krishna, N. Joshi

    2004-01-01

    86 patients, working in a chemical factory dealing with Chrome manufacturing job, were referred by Health Inspectai to F S 1 S Hospital O PD 32 patients out of above were found to be having Nasal septal perforation and were recommended to Medical Board for consideration of compensation as cases of Occupational hazard

  18. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists

    OpenAIRE

    Brant, Tereza C S; Yoshida, Carolina T; Tomas de S. Carvalho; Nicola, Marina L; Jocimar. A. Martins; Lays M. Braga; Regiani C. de Oliveira; Vilma Leyton; Carmen S. de André; Saldiva, Paulo H. N.; Rubin, Bruce K.; Naomi K. Nakagawa

    2014-01-01

    OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS:...

  19. Effect of Mupirocin on Nasal Carriage of Staphylococcus Aureus

    NARCIS (Netherlands)

    M. Bulanda; M. Gruszka; B. Heczko

    1989-01-01

    textabstractMupirocin eliminates nasal carriage of staphylococcal aureus among medical and surgical personnel for periode varying from several weeks upto one year. In persons recolonized after therapy densites of S. aureus population in nares were much lower than in the same persons before therapy.

  20. Case Report of Nasal Polyp Treated by Acupuncture

    Institute of Scientific and Technical Information of China (English)

    蒋传义

    2007-01-01

    @@ A Patient, female, student, nineteen years old.She was diagnosed with rhinitis and nasal polyps at the age of 17, and was treated with many methods,but the disease was not cured. The patient and her parents were fearful of surgical treatment, so she came for acupuncture therapy.

  1. Deviation of viscous drops at chemical steps

    CERN Document Server

    Semprebon, Ciro; Filippi, Daniele; Perlini, Luca; Pierno, Matteo; Brinkmann, Martin; Mistura, Giampaolo

    2016-01-01

    We present systematic wetting experiments and numerical simulations of gravity driven liquid drops sliding on a plane substrate decorated with a linear chemical step. Surprisingly, the optimal direction to observe crossing is not the one perpendicular to the step, but a finite angle that depends on the material parameters. We computed the landscapes of the force acting on the drop by means of a contact line mobility model showing that contact angle hysteresis dominates the dynamics at the step and determines whether the drop passes onto the lower substrate. This analysis is very well supported by the experimental dynamic phase diagram in terms of pinning, crossing, sliding and sliding followed by pinning.

  2. New Hydrodynamic Mechanism for Drop Coarsening

    CERN Document Server

    Nikolayev, Vadim; Guenoun, Patrick

    2016-01-01

    We discuss a new mechanism of drop coarsening due to coalescence only, which describes the late stages of phase separation in fluids. Depending on the volume fraction of the minority phase, we identify two different regimes of growth, where the drops are interconnected and their characteristic size grows linearly with time, and where the spherical drops are disconnected and the growth follows (time) 1/3. The transition between the two regimes is sharp and occurs at a well defined volume fraction of order 30%.

  3. Comparing the Effectiveness of Nasal Continuous Positive Airway Pressure (NCPAP) and High Flow Nasal Cannula (HFNC) in Prevention of Post Extubation Assisted Ventilation

    OpenAIRE

    Manizheh Mostafa-Gharehbaghi; Hooshyar Mojabi

    2015-01-01

    Background: There is a growing trend toward avoidance of intubation and mechanical ventilation for preterm neonates. Noninvasive ventilation can be provided by a variety of ways including nasal cannula. Objectives: This study was conducted to compare the efficacy and safety of Humidified high Flow Nasal Cannula (HFNC) and nasal CPAP for respiratory support after surfactant administration in preterm newborn infants with respiratory distress syndrome. Patients and Methods: In this r...

  4. Correction of nasal deformity in infants with unilateral cleft lip and palate using multiple digital techniques.

    Science.gov (United States)

    Zheng, Yaqi; Zhang, Dapeng; Qin, Tian; Wu, Guofeng

    2016-06-01

    Presurgical correction of severe nasal deformities before cheiloplasty is often recommended for infants with cleft lip and palate. This article describes an approach for the computer-aided design and fabrication of a nasal molding stent. A 3-dimensional photogrammetric system was used to obtain the shape information of the nosewing that was then built as the nostril support for the nasal molding stent. The stent was fabricated automatically with a rapid prototyping machine. This technique may be an alternative approach to presurgical nasal molding in the clinic. Moreover, the patient's nasal morphology can be saved as clinical data for future study. PMID:26724850

  5. Staphylococcus aureus and the ecology of the nasal microbiome

    DEFF Research Database (Denmark)

    Liu, Cindy M; Price, Lance B; Hungate, Bruce A;

    2015-01-01

    The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus......, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization....

  6. NUTRITIONAL STATUS, VITAMIN D AND NASAL COLONIZATION IN SPINAL SURGERY

    Directory of Open Access Journals (Sweden)

    Diego Benone dos Santos

    2016-03-01

    Full Text Available ABSTRACT Objective: Evaluate the nutritional status, vitamin D, the serum albumin, and the nasal colonization by bacteria in a Brazilian population sample that included specifically patients undergoing spine surgery Methods: The serum albumin and vitamin D tests were performed on blood samples; nasal microbiological research was performed by swab and demographic information was collected. We studied the correlation between the tests and gender and age groups of patients. Results: Seventy-five patients were included. Of this total, 74 patients underwent testing of albumin levels, 64 of vitamin D and 41 underwent nasal swab. The mean of serum albumin was 3.76 g/dl (SD = 0.53 g/dl; 70.3% of subjects were considered normal and 29.7% showed hypoalbuminemia. Regarding vitamin D, the mean was 16.64 ng/ml (SD: 7.43 ng/ml; 64.1% of patients were considered deficient, 32.8% insufficient, and 3.1% were considered normal. There was significant difference between albumin and age (p=0.007, being that the greater the age, the lower the albumin. Hypoalbuminemia was significantly more frequent over 60 years (p<0.001. There was no correlation between vitamin D or nasal swab and age (p=0.603 and 0.725, respectively. The correlation between the tests and gender showed no significant difference in any of the parameters. Conclusion: The serum albumin and vitamin D levels and results of nasal swab were presented for a Brazilian sample of patients undergoing spine surgery. It was found correlation between hypoalbuminemia (inferring malnutrition and age group of patients. Almost all the patients had some degree of vitamin D deficiency, with no correlation with age.

  7. Aligner for Elastic Collisions of Dropped Balls.

    Science.gov (United States)

    Mellen, Walter Roy

    1995-01-01

    Discusses an aligner that permits dropping a stack of any number of balls of different sizes, elasticities, hardnesses, or types to observe the rebound of the top ball. Experimental results allow a reasonable comparison with theory. (MVL)

  8. Micro-splashing by drop impacts

    KAUST Repository

    Thoroddsen, Sigurdur T.

    2012-07-18

    We use ultra-high-speed video imaging to observe directly the earliest onset of prompt splashing when a drop impacts onto a smooth solid surface. We capture the start of the ejecta sheet travelling along the solid substrate and show how it breaks up immediately upon emergence from the underneath the drop. The resulting micro-droplets are much smaller and faster than previously reported and may have gone unobserved owing to their very small size and rapid ejection velocities, which approach 100 m s-1, for typical impact conditions of large rain drops. We propose a phenomenological mechanism which predicts the velocity and size distribution of the resulting microdroplets. We also observe azimuthal undulations which may help promote the earliest breakup of the ejecta. This instability occurs in the cusp in the free surface where the drop surface meets the radially ejected liquid sheet. © 2012 Cambridge University Press.

  9. Drop impact of shear thickening liquids

    CERN Document Server

    Boyer, Francois; Dijksman, J Frits; Lohse, Detlef

    2013-01-01

    The impact of drops of concentrated non-Brownian suspensions (cornstarch and polystyrene spheres) onto a solid surface is investigated experimentally. The spreading dynamics and maxi- mal deformation of the droplet of such shear thickening liquids are found to be markedly different from the impact of Newtonian drops. A particularly striking observation is that the maximal de- formation is independent of the drop velocity and that the deformation suddenly stops during the impact phase. Both observations are due to the shear-thickening rheology of the suspensions, as is theoretically explained from a balance between the kinetic energy and the viscously-dissipated en- ergy, from which we establish a scaling relation between drop maximal deformation and rheological parameters of concentrated suspensions.

  10. Shapes of Bubbles and Drops in Motion.

    Science.gov (United States)

    O'Connell, James

    2000-01-01

    Explains the shape distortions that take place in fluid packets (bubbles or drops) with steady flow motion by using the laws of Archimedes, Pascal, and Bernoulli rather than advanced vector calculus. (WRM)

  11. Physical Causes of Drop Size Distribution Variability

    Science.gov (United States)

    Zawadzki, I.

    Drop size distributions are measured at ground by instruments (disdrometers) that mostly sample one drop at a time or at best, a small number of drops simultaneously. To obtain a representative sample a time window of the observations is required. This introduces a spurious variability due to the differential fall speed of drops coupled with a highly variable field of precipitation in rapid displacement respect to the dis- drometer. A filter has been studied to minimize this spurious variability as well as instrumental uncertainty. The use of filtered data allows to see case to case differences in DSDs that are hidden in the large scatter in the raw data. These differences can be associated to physical processes revealed by a vertically pointing radar such as the de- gree of aggregation, riming, etc. Numerical modeling of particle size evolution using the quasi-stochastic growth equation serves as guide for the understanding of these processes.

  12. Rotating Drops of Axion Dark Matter

    CERN Document Server

    Davidson, Sacha

    2016-01-01

    We consider how QCD axions produced by the misalignment mechanism could form galactic dark matter halos. We recall that stationary, gravitationally stable axion field configurations have the size of an asteroid with masses of order $10^{-13} $ solar masses (because gradient pressure is insufficient to support a larger object). We call such field configurations "drops". We explore whether rotating drops could be larger, and find that their mass could increase by a factor ~ 10. Remarkably this mass is comparable to the mass of miniclusters generated from misalignment axions in the scenario where the axion is born after inflation. We speculate that misalignment axions today are in the form of drops, contributing to dark matter like a distribution of asteroids (and not as a coherent oscillating background field). We consider some observational signatures of the drops, which seem consistent with a galactic halo made of axion dark matter.

  13. As Fitness Levels Rise, Diabetes Risk Drops

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_158889.html As Fitness Levels Rise, Diabetes Risk Drops But change requires ... HealthDay News) -- A higher level of heart-lung fitness may reduce your risk for prediabetes or type ...

  14. The Efficacy of Ultrasonography in Identifying Fracture Patterns of Nasal Bone

    International Nuclear Information System (INIS)

    The purpose of this study was to know whether ultrasonography is proper diagnostic tool for decision of treatment method or not, as compared the efficacy of US in allowing identifying fracture patterns of nasal bone with that of CT. Fifty patients with nasal trauma were investigated prospectively by CT and US. According to CT and ultrasonographic findings, each case of nasal bone injury were rated as grade 1 (nasal injury but not fracture), grade 2 (simple fracture without displacement), grade 3 (unilateral simple fracture with displacement), grade 4 (bilateral simple fractures with displacement), and grade 5 (bilateral comminuted fractures with depression). Assessment for ultrasonographic method were defined as overestimations or underestimation according to whether the nasal fracture had been assigned a higher or lower grade at the review of the findings of CT. The correlation between the results of CT and ultrasonography were measured. In ultrasonographic estimation of grade of 50 cases of nasal bone injuries, there were correctly graded in 42 cases, overestimated in 5 cases, underestimated in 3 cases. In allowing accurate grading of nasal bone injury, images of nasal ultrasonography correlated closely with those of CT (r = 0.796). Nasal ultrasonography is a reliable method that allows appropriate grading of nasal bone injury and would be a useful first line imaging method in providing the detail necessary for proper management of patients with mild simple nasal bone injury

  15. Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formmaldehyde Dosimetry Predictions in the Rat, Monkey, and Human Nasal Passages

    Science.gov (United States)

    ABSTRACT Formaldehyde, a nasal carcinogen, is also an endogenous compound that is present in all living cells. Due to its high solubility and reactivity, quantitative risk estimates for inhaled formaldehyde rely on internal dose calculations in the upper respiratory tract which ...

  16. Stereoscopic PIV measurements of flow in the nasal cavity with high flow therapy

    Science.gov (United States)

    Spence, C. J. T.; Buchmann, N. A.; Jermy, M. C.; Moore, S. M.

    2011-04-01

    Knowledge of the airflow characteristics within the nasal cavity with nasal high flow (NHF) therapy and during unassisted breathing is essential to understand the treatment's efficacy. The distribution and velocity of the airflow in the nasal cavity with and without NHF cannula flow has been investigated using stereoscopic particle image velocimetry at steady peak expiration and inspiration. In vivo breathing flows were measured and dimensionally scaled to reproduce physiological conditions in vitro. A scaled model of the complete nasal cavity was constructed in transparent silicone and airflow simulated with an aqueous glycerine solution. NHF modifies nasal cavity flow patterns significantly, altering the proportion of inspiration and expiration through each passageway and producing jets with in vivo velocities up to 17.0 ms-1 for 30 l/min cannula flow. Velocity magnitudes differed appreciably between the left and right sides of the nasal cavity. The importance of using a three-component measurement technique when investigating nasal flows has been highlighted.

  17. Staphylococcus aureus and the ecology of the nasal microbiome

    DEFF Research Database (Denmark)

    Liu, Cindy M; Price, Lance B; Hungate, Bruce A; Abraham, Alison G; Larsen, Lisbeth A; Christensen, Kaare; Stegger, Marc; Skov, Robert; Andersen, Paal Skytt

    2015-01-01

    The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus...... colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization......, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization....

  18. Detection of helicobacter pylori in nasal polyps using rapid urease test and ELISA

    Directory of Open Access Journals (Sweden)

    Masood Kaviani

    2009-01-01

    Full Text Available Introduction: Nasal polyposis is an inflammatory condition of unknown etiology. Recently concerns regarding gastroesophageal reflux or helicobacter pylori as a possible pathologic cause of nasal polyps have been increasing. The present study was planned to investigate the presence of helicobacter pylori in nasal polyps. Materials and Methods: This case-control study was undertaken enrolling 37 patients with nasal polyps who had undergone nasal endoscopic sinus surgery and 38 control subjects. Biopsy specimens of nasal polyps and inferior turbinates were assessed by rapid urease test. Blood samples of both study and control subjects were evaluated for anti H.pylori IgG by ELISA. H. pylori status was regarded positive, if both tests were positive. Results: Seropositivity was more common in the patients with nasal polyps (66.2% than control subjects (36.8% (P

  19. Blood drop patterns: Formation and applications.

    Science.gov (United States)

    Chen, Ruoyang; Zhang, Liyuan; Zang, Duyang; Shen, Wei

    2016-05-01

    The drying of a drop of blood or plasma on a solid substrate leads to the formation of interesting and complex patterns. Inter- and intra-cellular and macromolecular interactions in the drying plasma or blood drop are responsible for the final morphologies of the dried patterns. Changes in these cellular and macromolecular components in blood caused by diseases have been suspected to cause changes in the dried drop patterns of plasma and whole blood, which could be used as simple diagnostic tools to identify the health of humans and livestock. However, complex physicochemical driving forces involved in the pattern formation are not fully understood. This review focuses on the scientific development in microscopic observations and pattern interpretation of dried plasma and whole blood samples, as well as the diagnostic applications of pattern analysis. Dried drop patterns of plasma consist of intricate visible cracks in the outer region and fine structures in the central region, which are mainly influenced by the presence and concentration of inorganic salts and proteins during drying. The shrinkage of macromolecular gel and its adhesion to the substrate surface have been thought to be responsible for the formation of the cracks. Dried drop patterns of whole blood have three characteristic zones; their formation as functions of drying time has been reported in the literature. Some research works have applied engineering treatment to the evaporation process of whole blood samples. The sensitivities of the resultant patterns to the relative humidity of the environment, the wettability of the substrates, and the size of the drop have been reported. These research works shed light on the mechanisms of spreading, evaporation, gelation, and crack formation of the blood drops on solid substrates, as well as on the potential applications of dried drop patterns of plasma and whole blood in diagnosis. PMID:26988066

  20. Electrochemistry in an acoustically levitated drop.

    Science.gov (United States)

    Chainani, Edward T; Ngo, Khanh T; Scheeline, Alexander

    2013-02-19

    Levitated drops show potential as microreactors, especially when radicals are present as reactants or products. Solid/liquid interfaces are absent or minimized, avoiding adsorption and interfacial reaction of conventional microfluidics. We report amperometric detection in an acoustically levitated drop with simultaneous ballistic addition of reactant. A gold microelectrode sensor was fabricated with a lithographic process; active electrode area was defined by a photosensitive polyimide mask. The microdisk gold working electrode of radius 19 μm was characterized using ferrocenemethanol in aqueous buffer. Using cyclic voltammetry, the electrochemically active surface area was estimated by combining a recessed microdisk electrode model with the Randles-Sevcik equation. Computer-controlled ballistic introduction of reactant droplets into the levitated drop was developed. Chronoamperometric measurements of ferrocyanide added ballistically demonstrate electrochemical monitoring using the microfabricated electrode in a levitated drop. Although concentration increases with time due to drop evaporation, the extent of concentration is predictable with a linear evaporation model. Comparison of diffusion-limited currents in pendant and levitated drops show that convection arising from acoustic levitation causes an enhancement of diffusion-limited current on the order of 16%. PMID:23351154

  1. Leidenfrost drops on liquid baths: theory

    Science.gov (United States)

    Sobac, Benjamin; Rednikov, Alexei; Maquet, Laurent; Darbois-Texier, Baptiste; Duchesne, Alexis; Brandenbourger, Martin; Dorbolo, Stéphane; Colinet, Pierre

    2015-11-01

    It is well known that a liquid drop released over a very hot surface generally does not contact the surface nor boils but rather levitates over a thin vapor film generated by its own evaporation (Leidenfrost effect). In particular, the case of a hot (and flat) solid substrate has been extensively studied in recent years. In contrast, we here focus on Leidenfrost drops over a superheated liquid bath, addressing the problem theoretically and comparing our predictions with experimental results, detailed in a separate talk. We predict the geometry of the drop and of the liquid bath, based on the hydrostatic Young-Laplace and lubrication equations. A good agreement is observed with the available experimental data concerning the deformation of the liquid bath. The modeling also yields a rather complete insight into the shape of the drop. As in the case of a solid substrate, the vapor layer generally appears to be composed of a vapor pocket surrounded by a circular neck. The influences of the superheat and of the drop size are parametrically investigated. A number of scaling laws are established. Unlike the case of a solid substrate, no chimney instability was found in the range of drop size studied.

  2. Airflows generated by an impacting drop.

    Science.gov (United States)

    Bischofberger, Irmgard; Ray, Bahni; Morris, Jeffrey F; Lee, Taehun; Nagel, Sidney R

    2016-03-16

    A drop impacting a solid surface with sufficient velocity will splash and emit many small droplets. However, lowering the ambient air pressure suppresses splashing completely. This effect, robustly found for different liquid and substrate properties, raises the fundamental question of how air affects a spreading drop. In a combined experimental and numerical study we characterize the flow of air induced by the drop after it hits the substrate, using a modified Schlieren optics technique combined with high-speed video imaging and Lattice-Boltzmann simulations. Our experiments reveal the emergence of air structures on different length scales. On large scales, the airflow induced in the drop's wake leads to vortex structures due to interaction with the substrate. On smaller scales, we visualize a ring structure above the outer edge of the spreading liquid generated by the spreading of the drop. Our simulations reveal the interaction between the wake vorticity and the flows originating from the rapidly escaping air from below the impacting drop. We show that the vorticity is governed by a balance between inertial and viscous forces in the air, and is unrelated to the splashing threshold. PMID:26809314

  3. Drops can bounce from perfectly hydrophilic surfaces

    Science.gov (United States)

    Kolinski, J. M.; Mahadevan, L.; Rubinstein, S. M.

    2014-10-01

    Drops are well known to rebound from superhydrophobic surfaces and from liquid surfaces. Here, we show that drops can also rebound from a superhydrophilic solid surface such as an atomically smooth mica sheet. However, the coefficient of restitution CR associated with this process is significantly lower than that associated with rebound from superhydrophobic surfaces. A direct imaging method allows us to characterize the dynamics of the deformation of the drop in entering the vicinity of the surface. We find that drop bouncing occurs without the drop ever touching the solid and there is a nanometer-scale film of air that separates the liquid and solid, suggesting that shear in the air film is the dominant source of dissipation during rebound. Furthermore, we see that any discrete nanometer-height defects on an otherwise hydrophilic surface, such as treated glass, completely inhibits the bouncing of the drop, causing the liquid to wet the surface. Our study adds a new facet to the dynamics of droplet impact by emphasizing that the thin film of air can play a role not just in the context of splashing but also bouncing, while highlighting the role of rare surface defects in inhibiting this response.

  4. A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps.

    Science.gov (United States)

    Kim, Dong-Young; Lee, Sun Hye; Carter, Roderick G; Kato, Atsushi; Schleimer, Robert P; Cho, Seong H

    2016-08-01

    Animal model systems are invaluable for examining human diseases. Our laboratory recently established a mouse model of nasal polyps (NPs) and investigated similarities and differences between this mouse model and human NPs. We especially focus on the hypothesis that B cell activation occurs during NP generation in the murine model. After induction of ovalbumin-induced allergic rhinosinusitis, 6% ovalbumin and Staphylococcus aureus enterotoxin B (10 ng) were instilled into the nasal cavity of mice three times per week for 8 weeks. The development of structures that somewhat resemble NPs (which we will refer to as NPs) was confirmed by hematoxylin and eosin staining. The mRNA and protein levels of various inflammatory cell markers and mediators were measured by real-time PCR in nasal tissue and by ELISA in nasal lavage fluid (NLF), respectively. Total Ig isotype levels in NLF were also quantitated using the Mouse Ig Isotyping Multiplex kit (EMD Millipore, Billerica, MA) on a Luminex 200 instrument (Life Technologies, Grand Island, NY). Similar to human NPs, there were significant increases in gene expression of inflammatory cell markers, such as CD19, CD138, CD11c, and mast cell protease-6 in nasal tissue samples of the NP group compared with those of the control group. In further investigations of B cell activation, mRNA expressions of B cell activating factor and a proliferation-inducing ligand were found to be significantly increased in mouse NP tissue. B cell-activating factor protein concentration and IgA and IgG1 levels in NLF were significantly higher in the NP group compared with the control group. In this study, the NP mouse model demonstrated enhanced B cell responses, which are reminiscent of B cell responses in human NPs. PMID:27163839

  5. Sensitivity and specificity of hypopnoea detection using nasal pressure in the presence of a nasal expiratory resistive device (Provent®)

    International Nuclear Information System (INIS)

    Nasal expiratory resistive valves (Provent®) have been proposed as novel therapy for obstructive sleep apnea. We compared pressure measurements from a standard nasal pressure catheter used to assess nasal airflow during sleep with those from nasal expiratory resistive device with attached proprietary nasal pressure cannula. Nasal pressure cannula or Provent® + proprietary nasal pressure cannula were attached to a bench model of human anterior nares and nasal passages, and pressure measured (P). Respiratory airflows generated by a subject breathing were applied to rear of model and airflow ( V-dot ) measured via pneumotachograph. Airflow amplitude (Δ V-dot ) was plotted against pressure amplitude (ΔP). Hypopnoea detection (<50% Δ V-dot ) sensitivity and specificity was tested by expressing ΔP in terms of two reference breaths: reference breath 1, Δ V-dot 0.55 L s−1 = 100%; and reference breath 2, Δ V-dot 0.45 L s−1 = 100%. ΔP/Δ V-dot relationships were linear for Δ V-dot  ≤ 0.55 L s−1; ΔP = 0.37ΔV + 0.16 (nasal pressure cannula), ΔP = 2.7ΔV + 0.12 (Provent® + proprietary nasal pressure cannula); both R2 > 0.65, p < 0.0001; p < 0.0001 for between slope difference). For nasal pressure cannula, specificity of hypopnoea detection differed between reference breaths one and two (80.2% and 40.0%, respectively), and Provent® + proprietary nasal pressure cannula (30.3% and 74.2%, respectively). Quantification of airflow obstruction in the presence of Provent® + proprietary nasal pressure cannula is greatly influenced by the reference breath chosen to determine a reduction in nasal airflow. Reported variability in therapeutic response to nasal expiratory resistive devices may relate to differences in measurement technique specificity used to quantify the severity of sleep disordered breathing. (paper)

  6. Effects of heated humidification and topical steroids on compliance, nasal symptoms, and quality of life in patients with obstructive sleep apnea syndrome using nasal continuous positive airway pressure.

    LENUS (Irish Health Repository)

    Ryan, Silke

    2012-02-01

    BACKGROUND: Nasal side effects are common in patients with obstructive sleep apnea syndrome (OSAS) starting on nasal continuous positive airway pressure (CPAP) therapy. We tested the hypothesis that heated humidification or nasal topical steroids improve compliance, nasal side effects and quality of life in this patient group. METHODS: 125 patients with the established diagnosis of OSAS (apnea\\/hypopnea index > or = 10\\/h), who tolerated CPAP via a nasal mask, and who had a successful CPAP titration were randomized to 4 weeks of dry CPAP, humidified CPAP or CPAP with additional topical nasal steroid application (fluticasone, GlaxoWellcome). Groups were similar in all demographic variables and in frequency of nasal symptoms at baseline. Outcome measures were objective compliance, quality of life (short form 36), subjective sleepiness (Epworth Sleepiness Scale score) and nasal symptoms such as runny, dry or blocked nose, sneezing and headaches; all variables assessed using a validated questionnaire and by direct interview. RESULTS: There was no difference in compliance between groups after 4 weeks (dry: 5.21 +\\/- 1.66 h\\/night, fluticasone: 5.66 +\\/- 1.68, humidifier: 5.21 +\\/- 1.84; p = 0.444). Quality of life and subjective sleepiness improved in all groups, but there were no differences in the extent of improvement. Nasal Symptoms were less frequently reported in the humidifier group (28%) than in the remaining groups (dry: 70%, fluticasone: 53%, p = 0.002). However, the addition of fluticasone resulted in increased frequency of sneezing. CONCLUSION: The addition of a humidifier, but not nasal steroids decreases the frequency of nasal symptoms in unselected OSAS patients initiating CPAP therapy; however compliance and quality of life remain unaltered.

  7. The Drop Tower Bremen -Experiment Operation

    Science.gov (United States)

    Könemann, Thorben; von Kampen, Peter; Rath, Hans J.

    The idea behind the drop tower facility of the Center of Applied Space Technology and Micro-gravity (ZARM) in Bremen is to provide an inimitable technical opportunity of a daily access to short-term weightlessness on earth. In this way ZARM`s european unique ground-based microgravity laboratory displays an excellent economic alternative for research in space-related conditions at low costs comparable to orbital platforms. Many national and international ex-perimentalists motivated by these prospects decide to benefit from the high-quality and easy accessible microgravity environment only provided by the Drop Tower Bremen. Corresponding experiments in reduced gravity could open new perspectives of investigation methods and give scientists an impressive potential for a future technology and multidisciplinary applications on different research fields like Fundamental Physics, Astrophysics, Fluid Dynamics, Combus-tion, Material Science, Chemistry and Biology. Generally, realizing microgravity experiments at ZARM`s drop tower facility meet new requirements of the experimental hardware and may lead to some technical constraints in the setups. In any case the ZARM Drop Tower Operation and Service Company (ZARM FAB mbH) maintaining the drop tower facility is prepared to as-sist experimentalists by offering own air-conditioned laboratories, clean rooms, workshops and consulting engineers, as well as scientific personal. Furthermore, ZARM`s on-site apartment can be used for accommodations during the experiment campaigns. In terms of approaching drop tower experimenting, consulting of experimentalists is mandatory to successfully accomplish the pursued drop or catapult capsule experiment. For this purpose there will be a lot of expertise and help given by ZARM FAB mbH in strong cooperation to-gether with the experimentalists. However, in comparison to standard laboratory setups the drop or catapult capsule setup seems to be completely different at first view. While defining a

  8. Shape oscillation of a levitated drop in an acoustic field

    OpenAIRE

    Ran, Weiyu; Fredericks, Steven; Saylor, John R.

    2013-01-01

    A `star drop' refers to the patterns created when a drop, flattened by some force, is excited into shape mode oscillations. These patterns are perhaps best understood as the two dimensional analog to the more common three dimensional shape mode oscillations. In this fluid dynamics video an ultrasonic standing wave was used to levitate a liquid drop. The drop was then flattened into a disk by increasing the field strength. This flattened drop was then excited to create star drop patterns by ex...

  9. Rolling ferrofluid drop on the surface of a liquid

    OpenAIRE

    Sterr, V.; R.Krauss; Morozov, K. I.; Rehberg, I.; Engel, A.; Richter, R.

    2008-01-01

    We report on the controlled transport of drops of magnetic liquid, which are swimming on top of a non-magnetic liquid layer. A magnetic field which is rotating in a vertical plane creates a torque on the drop. Due to surface stresses within the immiscible liquid beneath, the drop is propelled forward. We measure the drop speed for different field amplitudes, field frequencies and drop volumes. Simplifying theoretical models describe the drop either as a solid sphere with a Navier slip boundar...

  10. Acute bilateral isolated foot drop: Report of two cases

    OpenAIRE

    Kertmen, H.; Gürer, B.; Yimaz, E. R.; Sekerci, Z.

    2015-01-01

    Foot drop is defined as the weakness of the foot and ankle dorsiflexion. Acute unilateral foot drop is a well-documented entity, whereas bilateral foot drop is rarely documented. Slowly progressing bilateral foot drop may occur with various metabolic causes, parasagittal intracranial pathologies, and cauda equina syndrome. Acute onset of bilateral foot drop due to disc herniation is extremely rare. Here we present two cases of acute bilateral foot drop due to disc herniation. The first patien...

  11. Shape oscillation of a levitated drop in an acoustic field

    CERN Document Server

    Ran, Weiyu

    2013-01-01

    A `star drop' refers to the patterns created when a drop, flattened by some force, is excited into shape mode oscillations. These patterns are perhaps best understood as the two dimensional analog to the more common three dimensional shape mode oscillations. In this fluid dynamics video an ultrasonic standing wave was used to levitate a liquid drop. The drop was then flattened into a disk by increasing the field strength. This flattened drop was then excited to create star drop patterns by exciting the drop at its resonance frequency. Different oscillatory modes were induced by varying the drop radius, fluid properties, and frequency at which the field strength was modulated.

  12. Effects of nasalance on the acoustical properties of the tenor passaggio and the head voice

    Science.gov (United States)

    Perna, Nicholas Kevin

    This study aims to measure the effect that nasality has on the acoustical properties of the tenor passaggio and head voice. Not to be confused with forward resonance, nasality here will be defined as nasalance, the reading of a Nasometer, or the percentage of nasal and oral airflow during phonation. A previous study by Peer Birch et al. has shown that professional tenors used higher percentages of nasalance through their passaggio. They hypothesized that tenors used nasalance to make slight timbral adjustments as they ascended through passaggio. Other well respected authors including Richard Miller and William McIver have claimed that teaching registration issues is the most important component of training young tenors. It seemed logical to measure the acoustic effects of nasalance on the tenor passaggio and head voice. Eight professional operatic tenors participated as subjects performing numerous vocal exercises that demonstrated various registration events. These examples were recorded and analyzed using a Nasometer and Voce Vista Pro Software. Tenors did generally show an increase of nasalance during an ascending B-flat major scale on the vowels [i] and [u]. Perhaps the most revealing result was that six of seven tenors showed at least a 5-10% increase in nasalance on the note after their primary register transition on the vowel of [a]. It is suggested that this phenomenon receive further empirical scrutiny, because, if true, pedagogues could use nasalance as a tool for helping a young tenor ascend through his passaggio.

  13. An acoustic study of nasal consonants in three Central Australian languages.

    Science.gov (United States)

    Tabain, Marija; Butcher, Andrew; Breen, Gavan; Beare, Richard

    2016-02-01

    This study presents nasal consonant data from 21 speakers of three Central Australian languages: Arrernte, Pitjantjatjara and Warlpiri. The six nasals considered are bilabial /m/, dental /n/, alveolar /n/, retroflex /ɳ/, alveo-palatal /ɲ/, and velar /ŋ/. Nasal formant and bandwidth values are examined, as are the locations of spectral minima. Several differences are found between the bilabial /m/ and the velar /ŋ/, and also the palatal /ɲ/. The remaining coronal nasals /n n ɳ/ are not well differentiated within the nasal murmur, but their average bandwidths are lower than for the other nasal consonants. Broader spectral shape measures (Centre of Gravity and Standard Deviation) are also considered, and comparisons are made with data for stops and laterals in these languages based on the same spectral measures. It is suggested that nasals are not as easily differentiated using the various measures examined here as are stops and laterals. It is also suggested that existing models of nasal consonants do not fully account for the observed differences between the various nasal places of articulation; and that oral formants, in addition to anti-formants, contribute substantially to the output spectrum of nasal consonants. PMID:26936570

  14. MR findings of nasal cavity lesions showing the infundibular widening on

    Energy Technology Data Exchange (ETDEWEB)

    Youn, Eun Kyung; Lee, Young Uk; Lee, Young Rae [Kangbuk Samsung Hospital, Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-03-01

    Several kinds of nasal cavity lesions located in the region of the infundibulum on CT. At such time, the visualization of these lesions is very similar. The purpose of this study was to differentially diagnose these nasal cavity lesions through evaluation of the MR findings. In 51 cases of pathologically proven nasal cavity masses which on CT showed infundibular widening, we retrospectively evaluated the MR findings. The cases involved prolapsed antral mucosa from sinusitis(n=15), inverted papilloma(n=10), antrochoanal polyp(n=10), aspergillosis(n=9), and nasal polyp(n=7). All patients underwent both CT and MR. imaging. In all cases, CT findings were similar ; soft tissue masses filling the maxillary sinus and nasal cavity were associated with infundibular widening caused by pressure on the uncinate process, leading to erosion. Differential diagnosis by CT was very difficult ; MR T2 weighted imaging was most effective for differential diagnosis of these nasal cavity masses. Prolapsed antral mucosa showed central inhomogeneous mixed signal intensity, with a peripheral rim of hyperintensity along the sinus wall and nasal component. Antrochoanal polyps showed homogeneous bright signal intensity of the antral and nasal component. Aspergillosis showed central dark signal foci. Inverted papillomas showed mixed intermediate and high intensity mixed with high signal intensity. Nasal polyps showed striation mixed of intermediate and high signal intensity, while nasal polyp showed striation of intermediate and high intensity. On Gd-enhanced T1 weighted images, prolapsed antral mucosa and antrochoanal polyp showed peripheral rim enhancement of the antral and nasal component. In contrast, inverted papilloma and nasal polyp showed intense enhancement of the mass and can be separate from the sinus inflammatory disease. Various nasal cavity masses showing infundibular widening on CT can be differentiated on MR images, especially of these are T2 weighted or contrast enhanced T1

  15. Drop impact entrapment of bubble rings

    KAUST Repository

    Thoraval, M.-J.

    2013-04-29

    We use ultra-high-speed video imaging to look at the initial contact of a drop impacting on a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et al. (Phys. Rev. Lett., vol. 108, 2012, article 264506). These dynamics mainly occur within 50 -s after the first contact, requiring imaging at 1 million f.p.s. For a water drop impacting on a thin layer of water, the entrapment of isolated bubbles starts through azimuthal instability, which forms at low impact velocities, in the neck connecting the drop and pool. For Reynolds number Re above -12 000, up to 10 partial bubble rings have been observed at the base of the ejecta, starting when the contact is -20% of the drop size. More regular bubble rings are observed for a pool of ethanol or methanol. The video imaging shows rotation around some of these air cylinders, which can temporarily delay their breakup into micro-bubbles. The different refractive index in the pool liquid reveals the destabilization of the vortices and the formation of streamwise vortices and intricate vortex tangles. Fine-scale axisymmetry is thereby destroyed. We show also that the shape of the drop has a strong influence on these dynamics. 2013 Cambridge University Press.

  16. Drops with non-circular footprints

    Science.gov (United States)

    Ravazzoli, Pablo D.; González, Alejandro G.; Diez, Javier A.

    2016-04-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. These drops are consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to the hysteresis of the contact angle since there is a wetting process in some parts of the contact line, while a dewetting occurs in other parts. Here, we obtain a characteristic drop shape from the rupture of a long liquid filament sitting on a solid substrate. We analyze its shape and contact angles by means of goniometric and refractive techniques. We also find a non-trivial steady state solution for the drop shape within the long wave approximation (lubrication theory), and we compare most of its features with experimental data. This solution is presented both in Cartesian and polar coordinates, whose constants must be determined by a certain group of measured parameters. Besides, we obtain the dynamics of the drop generation from numerical simulations of the full Navier-Stokes equation, where we emulate the hysteretic effects with an appropriate spatial distribution of the static contact angle over the substrate.

  17. Drops with non-circular footprints

    CERN Document Server

    Ravazzoli, Pablo D; Diez, Javier A

    2015-01-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. This type of drops is a consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to hysteresis effects of the contact angle since some parts of the contact line are wetting, while others are dewetting. Here, we obtain a peculiar drop shape from the rupture of a long liquid filament sitting on a solid substrate, and analyze its shape and contact angles by means of goniometric and refractive techniques. We also find a non--trivial steady state solution for the drop shape within the long wave approximation (lubrication theory), and compare most of its features with experimental data. This solution is presented both in Cartesian and polar coordinates, whose constants must be determined by a certain group of measured parameters. Besides, we obtain the dynamics of the drop generation from numerical simulations of...

  18. Drop Testing Representative Multi-Canister Overpacks

    Energy Technology Data Exchange (ETDEWEB)

    Snow, Spencer D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Morton, Dana K. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-06-01

    The objective of the work reported herein was to determine the ability of the Multi- Canister Overpack (MCO) canister design to maintain its containment boundary after an accidental drop event. Two test MCO canisters were assembled at Hanford, prepared for testing at the Idaho National Engineering and Environmental Laboratory (INEEL), drop tested at Sandia National Laboratories, and evaluated back at the INEEL. In addition to the actual testing efforts, finite element plastic analysis techniques were used to make both pre-test and post-test predictions of the test MCOs structural deformations. The completed effort has demonstrated that the canister design is capable of maintaining a 50 psig pressure boundary after drop testing. Based on helium leak testing methods, one test MCO was determined to have a leakage rate not greater than 1x10-5 std cc/sec (prior internal helium presence prevented a more rigorous test) and the remaining test MCO had a measured leakage rate less than 1x10-7 std cc/sec (i.e., a leaktight containment) after the drop test. The effort has also demonstrated the capability of finite element methods using plastic analysis techniques to accurately predict the structural deformations of canisters subjected to an accidental drop event.

  19. Drop splash on a smooth, dry surface

    Science.gov (United States)

    Riboux, Guillaume; Gordillo, Jose Manuel; Korobkin, Alexander

    2013-11-01

    It is our purpose here to determine the conditions under which a drop of a given liquid with a known radius R impacting against a smooth impermeable surface at a velocity V, will either spread axisymmetrically onto the substrate or will create a splash, giving rise to usually undesired star-shaped patterns. In our experimental setup, drops are generated injecting low viscosity liquids falling under the action of gravity from a stainless steel hypodermic needle. The experimental observations using two high speed cameras operating simultaneously and placed perpendicularly to each other reveal that, initially, the drop deforms axisymmetrically, with A (T) the radius of the wetted area. For high enough values of the drop impact velocity, a thin sheet of liquid starts to be ejected from A (T) at a velocity Vjet > V for instants of time such that T >=Tc . If Vjet is above a certain threshold, which depends on the solid wetting properties as well as on the material properties of both the liquid and the atmospheric gas, the rim of the lamella dewets the solid to finally break into drops. Using Wagner's theory we demonstrate that A (T) =√{ 3 RVT } and our results also reveal that Tc We - 1 / 2 =(ρV2 R / σ) - 1 / 2 and Vjet We 1 / 4 .

  20. Local tissue hypoxia and formation of nasal polyps

    Institute of Scientific and Technical Information of China (English)

    姜舒; 董震; 朱冬冬; 杨占泉

    2003-01-01

    Objective To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP). Methods Epithelial cells of NP and inferior turbinate (IT) were cultured serum-fr ee under normal oxygen and hypoxic circumstances with stimulation of IL-1β and TNFα. The vascular endothelial growth factor (VEGF)mRNA and VEGF protein leve ls of the cultured cells were detected using in situ hybridization and ELISA, re spectively. Results The expression of VEGF mRNA was significantly higher in epithelial cells of NP t han in IT exposed to pro-inflammatory cytokines or hypoxia (P<0.01). VEGF levels were higher in NP epithelial cells than those of IT (P<0.01) under hypoxia.Conclusion VEGF-induced by hypoxia is very important for the early stages of forming polyps.

  1. The nasopharynx, the paranasal sinuses, and nasal cavity

    International Nuclear Information System (INIS)

    In considering malignancies of the head and neck region, a number of sites mutually lend themselves to the presentation of diagnostic imaging and treatment. Some of these sites are the nasopharynx, the paranasal sinuses, and the nasal cavity, which are primarily concerned with the intake of air and are, in essence, the beginning of the respiratory tract. Because of its function, the tract is exposed to many environmental antigens and pollutants. For example, carcinoma of the nasopharynx is especially common among southern Chinese and seems to be related to environmental rather than genetic factors. However, the Epstein-Barr virus is associated with nasopharyngeal carcinomas in all races. The incidence of carcinomas of the nasal cavity and the paranasal sinuses has been found to be increased in furniture workers and appears to be related to wood dust inhalation

  2. Mometasone furoate nasal spray for the treatment of asthma

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke

    2016-01-01

    INTRODUCTION: Asthma is a common respiratory disease characterized by airway inflammation, bronchoconstriction and airway hyperresponsiveness and symptoms such as coughing, wheezing, shortness of breath and chest tightness. Allergic rhinitis is a common comorbidity in asthma and glucocorticoids are...... associated with an improvement in asthma control. AREAS COVERED: This current paper reviews the current knowledge on the effect of mometasone furoate nasal spray in the treatment of asthma and includes clinical trials in which both subjective and objective outcomes are assessed. EXPERT OPINION: To date, only...... few clinical studies have investigated the effect of nasal steroids in the treatment of asthma. The studies investigating the effect of MFNS report contradicting results, although the most well-designed study to answer this question finds no improvement in asthma control. Thus, it seems unlikely that...

  3. Nasal fracture in sports: its occurrence and importance

    Directory of Open Access Journals (Sweden)

    Neide Pena Coto

    2010-07-01

    Full Text Available Introduction: The increasing number of participants in various sports,mainly those practiced indoors,brought a significant increase of orofacial injuries in sports,especially nasal fractures, which rank third in incidence in all sports.Objective and literature review: To study the causes, ccurrence and importance of nasal fracture in sports,as providing ways of protecting the maxillofacial area in sports is the responsibility of the dentist,area in which Sports Dentistry is establishing itself.Conclusion: A long athlete withdrawal carries great physical and psychological damage,as well as financial loss to his club.Attention in providing ways of protection for the athlete is required.

  4. Development of brachytherapy technique for nasal tumors in dogs

    International Nuclear Information System (INIS)

    Two groups of 4 dogs underwent nasal and ethmoidal turbinectomies followed by irradiation (mean minimal) doses of 5,390 and 6,550 cGy of radiation, respectively from implanted intracavitary sources of iridium 192. Two dogs from each group were euthanatized for histologic evaluation at 3 months after irradiation. The remaining 2 dogs from each group were euthanatized for similar evaluation at 6 months after irradiation. During the course of the study, few clinical complications were encountered. Histologic evaluation of the tissues forming the nasal passages revealed loss of epithelial lining and fibrous tissue replacement of surrounding bone. A direct correlation of pathologic changes could not be associated with the amount of radiation received, but there seemed to be a tendency for greater change in those dogs given higher doses and those kept alive for 6 months

  5. [Mensurement of airflow resistance in neonatal prongs of nasal CPAP

    Science.gov (United States)

    Sampietro, V I; Azevedo, M P; Resende, J G

    2000-01-01

    OBJECTIVE: To measure airflow resistance in prongs of nasal CPAP, making use of different gas admission flow (GAF) in the ventilation circuit, in different internal diameters of the nasal prongs, besides verifying whether a GAF responding only to the demand of three times the minute-volume(MV) is enough to the circuit not to be cause of CO(2) retention. METHODOLOGY: Nasal prongs, assembled in the original circuits, were used, having their prongs kept open to the atmosphere. Pressure was read at a pressure monitor, in water centimeters, connected to the appropriate entrance of the circuit. A flowmeter balanced to the pressure was used, gauged at 50 psi, installed to the oxygen net of the Hospital, connected to the assessing set of the CPAP circuit. Initially, making use of the 8 l/min flow and keeping the exhaling set of the circuit closed, it was possible to eliminate the nasal prongs larger than two once the measured resistance was equal to zero. Having nasal parts number zero, 1 and 2 selected for this study, the system was then assembled as for the neonate: the inhaling set to the gas source and the exhaling set sunk into different depths in the water seal (2, 4, 6 and 8 centimeters). At the level of patient analysis, in order to assess the CO(2) retention, a mechanical pulmonary ventilation device was used as gas source and a nasal CPAP circuit was assembled to the device in adequate places. GAF values and FiO(2) were determined in the commands of the mechanical ventilation device. The assessment of gas concentration in the ventilation circuit was made while assisting two newborns. Gas samples were obtained within the ventilation circuit in the system assessing set (samples A), and right after the distal prong to the gas entrance (samples B). To determine MV the Tidal Volume (considered 10ml/kg) was multiplied by the respiratory frequency of the patient; GAF was three times MV. RESULTS: To a maximum GAF of 8 litres/min, only prongs sized zero, 1 and 2 showed

  6. Case report 367: Hemangioma of the nasal bone

    International Nuclear Information System (INIS)

    In summary, an 18-year-old young woman presented with an expanding lesion of the nasal bone(s), with a prior history of gradual swelling of the nose. A past history of trauma sustained when she was struck by a tennis ball dated approximately five years before the current presentation. Plain film roentgenograms and a tomographic study showed an expanding lesion of the nasal bone(s) which had the appearance of benignity; the lesion was well demarcated with a narrow zone of transition. The lesional tissue contained small bony opacities in the form of circles and linear and curvilinear strands. The neoplasm was surgically excised and proved to be a benign hemangioma. (orig./SHA)

  7. Progress with volunteer studies of nasal deposition and clearance

    International Nuclear Information System (INIS)

    Inhalation is the main route of intake of radioactive material for workers, and can be an important pathway for members of the public following accidental releases of radioactivity to the environment. Much of the inhaled radioactivity initially deposits in the nose, typically over 40% for particles of aerodynamic diameter (dae) greater than 2 μm. However, there is remarkably little information on the clearance from the human nose of particles deposited during inhalation and, until now, none on the clearance of the significant fraction of material that remains in the nasal passage for more than 12 hours. NRPB is conducting a volunteer study to determine the effects of particle size and breathing pattern on particle deposition in, and clearance from, the human nasal passage. This article summarises results obtained to date. (author)

  8. Peak nasal inspiratory flow: uma possível ferramenta para a motricidade orofacial? Peak nasal inspiratory flow: a possible instrument in orofacial myology?

    Directory of Open Access Journals (Sweden)

    Andréa Rodrigues Motta

    2010-12-01

    Full Text Available Os fonoaudiólogos que atuam no campo da Motricidade Orofacial atendem com frequência, pacientes com obstrução nasal; entretanto, nem sempre o acesso ao profissional responsável pelo diagnóstico otorrinolaringológico é fácil. O Peak Nasal Inspiratory Flow é um instrumento barato, de fácil manuseio, amplamente citado na literatura internacional, que tem por objetivo avaliar a patência nasal. O objetivo do presente estudo foi realizar uma revisão da literatura acerca do Peak Nasal Inspiratory Flow, fornecendo subsídios para reflexões acerca de seu emprego nos distúrbios miofuncionais orofaciais e cervicais. Para tanto, foi realizada uma revisão da literatura nas bases de dados Medline, Cochrane Library, LILACS e SciELO empregando-se os descritores peak, inspiratory, nasal e flow. O Peak Nasal Inspiratory Flow mostrou-se uma técnica simples, barata, validada e com boa reprodutibilidade. Parece, portanto, tratar-se de um instrumento útil para avaliação da patência nasal, apesar de algumas limitações, fornecendo dados complementares ao diagnóstico miofuncional orofacial e cervical. Entretanto, estudos clínicos precisam ser conduzidos para que se comprove ou refute a hipótese.The speech-language pathologists that work in the Orofacial Myology field frequently have patients with nasal obstruction; however, the access to the professional responsible for the diagnosis can be difficult at times. The Peak Nasal Inspiratory Flow is a cheap and easy to handle instrument, broadly cited in the international literature, that has the aim to evaluate nasal patency. The aim of this study was to review the current literature regarding the Peak Nasal Inspiratory Flow, enabling considerations about its use in cervical and orofacial myology disorders. The literature review consulted Medline, Cochrane Library, LILACS and SciELO databases, using the keywords: peak, inspiratory, nasal and flow. The results showed that Peak Nasal Inspiratory Flow

  9. Mucosal melanoma of nasal cavity and paranasal sinus

    Directory of Open Access Journals (Sweden)

    Dwivedi Raghav

    2008-01-01

    Full Text Available Mucosal melanoma of the nasal cavity and paranasal sinuses is seldom encountered in routine ENT practice. These tumors have poor prognosis owing to higher rates of locoregional recurrence and distant metastasis. Various treatment modalities have been employed over time but the ideal treatment approach still remains an open issue. This article presents some commonly accepted guidelines in treating these rare mucosal neoplasms.

  10. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists

    OpenAIRE

    Brant, Tereza C S; Yoshida, Carolina T; de S. Carvalho, Tomas; Marina L. Nicola; Jocimar A. Martins; Lays M. Braga; de Oliveira, Regiani C; Leyton, Vilma; Carmen S. de André; Saldiva, Paulo H N; Rubin, Bruce K; Naomi K. Nakagawa

    2014-01-01

    OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urba...

  11. Primary Burkitt's Lymphoma in the Nasal Cavity and Paranasal Sinuses

    OpenAIRE

    Lee, Dong Hwan; Yu, Myeong Sang; Lee, Bong-Jae

    2013-01-01

    Burkitt's lymphoma is a highly aggressive small B-cell lymphoma. The treatment of choice is complex chemotherapy. As a rare tumor in the head and neck area, Burkitt's lymphoma usually involves cervical lymph nodes, and only fewer than 25% of cases involves extranodal regions. Involvement of the paranasal sinuses has been reported in only 14 cases in the past century. We describe here two patients with rare, sporadic, American type Burkitt's lymphoma involving the nasal cavity and paranasal si...

  12. Osteolytic nasal polyp of the maxillary sinus mimicking malignancy

    OpenAIRE

    Arvind Karikal; Sampathila Mahalinga Sharma; Anju Gopinath; Arathi Karikal

    2014-01-01

    We present an osteolytic nasal polyp of the maxillary sinus with clinical features and radiographic features mimicking that of a malignancy. Maxillary sinusitis being a common inflammatory condition progressed to cause destruction of the maxillary bone and spread into the facial soft tissue, which is quite a rare occurrence. We have discussed in detail the clinical, radiological, histopathology and management of this uncommon presentation of a common case.

  13. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists

    Directory of Open Access Journals (Sweden)

    Tereza C.S. Brant

    2014-01-01

    Full Text Available OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2 concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039. RESULTS: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m3 for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p = 0.036. CONCLUSION: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

  14. CAPILLARY HEMANGIOMA OF THE NASAL SEPTUM IN CHILDREN

    OpenAIRE

    Salman, Nergis; Baysal, Nakiye; Adabag, Aysegul; Yildiz, Ugur; Akin, Istemihan

    2012-01-01

    Lobular capillary hemangioma (LCH) is a benign vascular tumor, also known as, pyogenic granuloma. LCH appears on the skin, the oral mucosa, and, rarely, on the nasal mucosa. Trauma, hormones, viral oncogenes, microscopic arteriovenous malformations, and angiogenic growth factors have been implicated in the etiology of LCH lesions. LCH most commonly presents in the third decade of life but may present in persons of any age. It is considerably rare in children; only a few cases have been report...

  15. Saccade performance in the nasal and temporal hemifields

    DEFF Research Database (Denmark)

    Jóhannesson, Ómar Ingi; Ásgeirsson, Árni Gunnar; Kristjánsson, Árni

    2012-01-01

    differences for saccadic eye movements. There is also evidence for stronger retinotectal neural projection from the nasal than the temporal he- miretina. There is, accordingly, good reason to predict asymmetries in saccadic performance depending on which hemifield the saccade trigger stimuli are presented in...... asymmetry is surprising in light of previous findings of attentional asymmetries, it may reflect that cortical input to midbrain eye control centers mitigates any retinal and retinotectal asymmetry....

  16. Failure patterns following cobalt irradiation in dogs with nasal carcinoma

    International Nuclear Information System (INIS)

    The pattern of tumor recurrence was assessed in 24 dogs receiving cobalt radiation therapy for nasal carcinoma. Dogs were evaluated using nasal cavity computed tomography prior to treatment, and at 1, 3, 6 and 12 months after treatment, and at 6-month intervals thereafter if still alive. Dogs were treated with various combinations of total dose, and fraction size. Total doses were normalized to equivalent doses given in 3.0 Gy fractions. The extent of tumor regression or duration of tumor control were not dependent on absolute total dose, normalized total dose, or tumor type. The median duration of local control in all dogs was 312 days. Marked tumor regression was observed in 11 of the 24 dogs. Median duration of local control was significantly longer in dogs with marked tumor regression in comparison to dogs without tumor regression; 389 vs. 161 days respectively. When tumor recurrence was documented in dogs having tumor regression, the location of the recurrence was in the nasal cavity. No tumor recurred in a sinus or periorbital region, and only one geographic miss was detected. Tumor recurrence in the irradiated volume, including dogs with and without marked regression, was documented in 13 of the 24 dogs. The high local failure rate, coupled with the recurrence pattern in these dogs, suggests there may be an opportunity for improvement in local control through use of shrinking field techniques

  17. Is the human nasal cavity at risk from inhaled radionuclides?

    International Nuclear Information System (INIS)

    In a series of three life-span studies in which beagle dogs inhaled relatively soluble forms of beta-emitting radionuclides, a number of cancers of the nasal cavity have arisen at long times after the inhalation exposure. No such cancers were observed in the control dogs. Data obtained in other studies involving serial sacrifice of dogs that received these radionuclides in similar forms have shown that high local concentrations of the radionuclides can persist in nasal turbinates for long periods of time, depending on the physical half-life of the radionuclide inhaled. Several nasal carcinomas have also been observed in dogs injected with 137CsCl in which the relative concentrations of beta activity in the turbinate region were not as pronounced as in the above studies. Similar risks of sinonasal cancer were calculated for dogs in each of these studies regardless of differences in radionuclide, dosimetry, and route of administration. Since sinonasal cancers have occurred in people exposed to alpha-emitting radionuclides, it is reasonable to assume this could occur with beta emitters as well. Radiation protection guidelines should account for the sinonasal region being at risk. 23 refs., 1 fig., 6 tabs

  18. CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.

    Science.gov (United States)

    Sinha, Ian P; McBride, Antonia K S; Smith, Rachel; Fernandes, Ricardo M

    2015-09-01

    Severe respiratory failure develops in some infants with bronchiolitis because of a complex pathophysiologic process involving increased airways resistance, alveolar atelectasis, muscle fatigue, and hypoxemia due to mismatch between ventilation and perfusion. Nasal CPAP and high-flow nasal cannula (HFNC) oxygen may improve the work of breathing and oxygenation. Although the mechanisms behind these noninvasive modalities of respiratory support are not well understood, they may help infants by way of distending pressure and delivery of high concentrations of warmed and humidified oxygen. Observational studies of varying quality have suggested that CPAP and HFNC may confer direct physiologic benefits to infants with bronchiolitis and that their use has reduced the need for intubation. No trials to our knowledge, however, have compared CPAP with HFNC in bronchiolitis. Two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Two trials evaluated HFNC in bronchiolitis (one comparing it with headbox oxygen, the other with nebulized hypertonic saline), with the results not seeming to suggest important clinical or physiologic benefits. In this article, we review the pathophysiology of respiratory failure in bronchiolitis, discuss these trials in detail, and consider how future research studies may be designed to best evaluate CPAP and HFNC in bronchiolitis. PMID:25836649

  19. Defining the Best Nasal Tip Projection among Iranian Women

    Science.gov (United States)

    Mohebbi, Alireza; Jahandideh, Hesam; Faham, Zhaleh; Jafari, Morteza

    2016-01-01

    Rhinoplasty is one of the most complicated aesthetic surgeries. One important factor in nasal profile analysis before surgery is the NTP (Nasal Tip Projection). There has been controversy over defining the best tip projection and due to cultural differences there is a need to find the best formulation for Iranian noses. We selected 50 randomized patients. Lateral nasal views were captured from all of the patients. In order to equalize the photos, all tip rotations changed first to 105. We selected four methods for measuring NTP (Goode, Crumley 1, Crumley 2, and Powell and Humphreys). Based on these methods NTP was shown in four pictures. A questionnaire was designed for rating the pictures. Questionnaires were filled in by 3 different groups: rhinoplasty surgeons, general people, and artists. A total of 73 questionnaires were filled in. The analysis and comparison were done. Crumley 2 is the best NTP measurement method from the surgeons' and artists' view. Goode is the method preferred by general people. Powell & Humphreys method seems to be the worst method from all 3 groups' view. It seems that general people prefer smaller noses, because projection in Goode method is almost less than Crumley 2.

  20. Balloon sinuplasty: a new concept in the endoscopic nasal surgery

    Directory of Open Access Journals (Sweden)

    Nogueira Júnior, João Flávio

    2008-12-01

    Full Text Available Introduction: Sinus diseases affect millions of people annually. Clinical treatment is effective in most patients, but in case of failure of this therapy the functional endoscopic surgery is currently the treatment choice for surgical treatment. The objective of the functional endoscopic surgery is to increase the aeration and drainage of the involved paranasal sinuses, which allows for the adequate functioning of the nasal mucosa mucociliary clearance. However, this method still has some limitations, mainly because it removes the nasal mucosa and bone tissue, and it may lead to physiologic alterations of the nasosinusal mucosa and cicatricial fibrosis. Many of these patients could be benefited from less invasive methods, with larger nasal mucosa preservation. Since 2006, an even less invasive procedure was remarked in our specialty: the balloon dilatation of the paranasal sinus ostia. Objective: The objective of this article is to define the concept of sinuplasty, its action mechanism, and present the necessary material for the procedures performance; to describe the techniques with the equipment in a nasosinusal endoscopic surgery simulator model and review the current literature about the indications, complications, results, and follow-up of patients submitted to this procedure. Balloon sinuplasty is safe and appears to be effective in the improvement of the quality of life of patients not responsive to conventional clinical therapy. New applications and indications for this equipment should be described and researched.

  1. Rain Drop Measurement Techniques: A Review

    Directory of Open Access Journals (Sweden)

    Gopinath Kathiravelu

    2016-01-01

    Full Text Available For over a century there have been many studies that describe the use of rain drop measurement techniques. Initial manual measurement methods evolved due to improved technology to include photographic and, more recently, automated disdrometer and laser measurement techniques. Despite these numerous studies, there have been few comparative reviews of the range of methodologies, and their relative performance. This review explores the raindrop measurement techniques available, and summarizes and classifies the techniques according to the method or principle involved. The requirements of a robust raindrop measurement technique are suggested, and these are reviewed against existing rain drop measurement techniques to provide a comparative guide to the use of the range of techniques available for any research study. This review revealed that while advances in technology have allowed many of the deficiencies of early techniques to be eliminated, challenges remain in relation to the precision of the measurement of the size, shape, and velocity of rain drops.

  2. Lifetime of oil drops pressed by buoyancy against a planar interface: Large drops

    OpenAIRE

    Rojas, Clara; García-Sucre, Máximo; Urbina-Villalba, Germán

    2010-01-01

    In a previous report [10] it was shown that emulsion stability simulations are able to reproduce the lifetime of micrometer-size drops of hexadecane pressed by buoyancy against a planar water-hexadecane interface. It was confirmed that small drops (ri

  3. Coalescing drops in microfluidic parking networks: A multifunctional platform for drop-based microfluidics.

    Science.gov (United States)

    Bithi, Swastika S; Wang, William S; Sun, Meng; Blawzdziewicz, Jerzy; Vanapalli, Siva A

    2014-05-01

    Multiwell plate and pipette systems have revolutionized modern biological analysis; however, they have disadvantages because testing in the submicroliter range is challenging, and increasing the number of samples is expensive. We propose a new microfluidic methodology that delivers the functionality of multiwell plates and pipettes at the nanoliter scale by utilizing drop coalescence and confinement-guided breakup in microfluidic parking networks (MPNs). Highly monodisperse arrays of drops obtained using a hydrodynamic self-rectification process are parked at prescribed locations in the device, and our method allows subsequent drop manipulations such as fine-gradation dilutions, reactant addition, and fluid replacement while retaining microparticles contained in the sample. Our devices operate in a quasistatic regime where drop shapes are determined primarily by the channel geometry. Thus, the behavior of parked drops is insensitive to flow conditions. This insensitivity enables highly parallelized manipulation of drop arrays of different composition, without a need for fine-tuning the flow conditions and other system parameters. We also find that drop coalescence can be switched off above a critical capillary number, enabling individual addressability of drops in complex MPNs. The platform demonstrated here is a promising candidate for conducting multistep biological assays in a highly multiplexed manner, using thousands of submicroliter samples. PMID:25379078

  4. Analysis of the refloding pressure drop measurements

    International Nuclear Information System (INIS)

    These work draw a theoretical-experimental comparison from the total pressure drop results during the reflooding phase of a loss of coolant accident of a PWR. It was verified from this evaluation that the void fraction and the pressure drop models for the two-phase flow, including the subcooled boiling influence and the configuration, dont permit a satisfatory prediction of the experimental data. These differences can occur from the fact that the existing models are stablished, the majority, for the different conditions than those for the reflooding events. (author)

  5. Shuttlecock Velocity of a Badminton Drop Shot

    Directory of Open Access Journals (Sweden)

    Ampharin Ongvises

    2013-12-01

    Full Text Available In a badminton ‘drop shot’, the shuttlecock is struck by a non-rotating racquet at low speed. In this investigation, a shuttlecock was hit by a badminton racquet in a linear collision, simulating a drop shot. The collision was recorded with high-speed video and the velocities of the racquet and shuttlecock determined. The relationship between the impact velocity of the racquet and the velocity of the shuttlecock as it leaves the badminton racquet after collision was found to be proportional over the range tested.

  6. Shuttlecock Velocity of a Badminton Drop Shot

    Directory of Open Access Journals (Sweden)

    Ampharin Ongvises

    2013-01-01

    Full Text Available In a badminton ‘drop shot’, the shuttlecock is struck by a non-rotating racquet at low speed. In this investigation, a shuttlecock was hit by a badminton racquet in a linear collision, simulating a drop shot. The collision was recorded with high-speed video and the velocities of the racquet and shuttlecock determined. The relationship between the impact velocity of the racquet and the velocity of the shuttlecock as it leaves the badminton racquet after collision was found to be proportional over the range tested.

  7. Short time dynamics of viscous drop spreading

    OpenAIRE

    Eddi, Antonin; Winkels, Koen G.; Snoeijer, Jacco H.

    2012-01-01

    Liquid drops start spreading directly after coming into contact with a solid sub- strate. Although this phenomenon involves a three-phase contact line, the spread- ing motion can be very fast. We experimentally study the initial spreading dy- namics, characterized by the radius of the wetted area, for viscous drops. Using high-speed imaging with synchronized bottom and side views gives access to 6 decades of time resolution. We show that short time spreading does not exhibit a pure power-law ...

  8. Development of the Rod-Drop Technique

    International Nuclear Information System (INIS)

    The integral count technique is generalized, and then applied to a perturbation formula to estimate the influence of finite dropping times. In a second version of the integral method a weight factor t is introduced to suppress errors near the starting point. It enhances the influence of the medium times after the rod-drop which proved advantageous in the evaluation. This weighting method is still more generalized and applied to set up a system of equations to determine an arbitrary number of parameters in the negative reactivity if the time dependence of the power is known

  9. Linfoma Extranodal de Células NK/T tipo Nasal Extranodal Nasal type NK/T-Cell Lymphoma

    OpenAIRE

    Carlos S. Chiattone

    2009-01-01

    O Linfoma Extranodal de Células NK/T tipo Nasal tem uma distribuição geográfica peculiar, ocorrendo mais frequentemente em países orientais e na população nativa de alguns países da América Central e da América do Sul. Sua localização preferencial é na cavidade nasal e nos seios paranasais, mas pode acometer outras estruturas da chamada região médio-facial. Tem um padrão de disseminação com "homing" característico, incluindo pele, testículo, SNC e trato digestivo. Este linfoma, menos frequent...

  10. Experience in the management of patients with nasal fractures. Experiencia en el manejo de los pacientes con fracturas nasales.

    Directory of Open Access Journals (Sweden)

    Jorge Luis Estepa Pérez

    2009-03-01

    Full Text Available Background: Nasal fracture is the most frequent facial trauma; its immediate treatment help avoiding further complications. Objective: to characterize the patients with nasal fracture who meet the criteria for treatment. Method: An observational, descriptive study was developed, including all patients (114 of 15 years or more with nasal fracture received at the Emergency Maxilo-Facial Surgical Department in the provincial hospital of Cienfuegos from June 2006 to April 2007. The studies variables were age, sex, aetiology, clinical signs, classification depending on the fractures focus and direction of the trauma, treatment following the guidelines for good clinical practices and post-treatment assessment. Results: There was higher incidence of males and the age group between 15 and 44. The main cause of fracture were fights, the most frequent clinical sign was epistaxis. The most common fractures were closed fractures and lateral deviation fractures. Most of the patients received immediate treatment. Among the clinical postsurgical sing was nasal congestion. Conclusions: We proved that immediate care should be provided to patients with this kind of fractures with local anaesthesia to avoid further risks.Fundamento: La fractura nasal constituye el trauma más frecuente del macizo facial, tratarlas de forma inmediata evita complicaciones al paciente. Objetivo: Caracterizar los pacientes con fracturas nasales tributarios a tratamiento. Método: Se realizó un estudio observacional descriptivo que incluyó todos los pacientes (114 con 15 años de edad o más y que fueron atendidos con el diagnóstico de fractura nasal en el Servicio de Urgencias de Cirugía Máxilofacial del Hospital Provincial de Cienfuegos, en el período de junio 2006 a abril del 2007. Las variables estudiadas fueron edad, sexo, etiología, signos

  11. Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion.

    Science.gov (United States)

    Yazıcı, Hasmet

    2015-12-01

    Mucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and paranasal sinuses along with the trapped inhaled pathogens to the nasopharynx. Physiologic or pathologic situations that effect nasal MCC, such as temperature, humidity, nasal obstruction, allergic rhinitis, chronic infections, etc., lead to impaired MCC and related local or circumjacent system disorders. With this perspective, when a unified airway with a multiple disease principle is considered, investigating the relationship between adenoid hypertrophy (AH), otitis media with effusion (OME) and nasal MCC is logical. In this review, histological and physiologic properties of nasal MCC and its possible role involving pathologic situations such as AH and OME is discussed together with recent literature findings. PMID:26496764

  12. Ion activated in situ gel of gellan gum containing salbutamol sulphate for nasal administration.

    Science.gov (United States)

    Salunke, Sneha R; Patil, Sanjay B

    2016-06-01

    Nasal delivery is the promising approach for rapid onset of action and avoids the first pass metabolism. The main aim of present study was to develop a novel mucoadhesive in situ gel of salbutamol sulphate using gellan gum and hydroxylpropyl methyl cellulose (HPMC) for nasal administration. The formulations were prepared so as to have gelation at physiological ion content after nasal administration. Developed formulations were evaluated for gelation, viscosity, drug content, in vitro mucoadhesion, in vitro drug release study, ex vivo permeation, and histopathology. Formulations showed pH in the range of nasal cavity and optimum viscosity for nasal administration. The mucoadhesive force depends upon concentration of HPMC and drug release was found to be 97.34% in 11h. The histopathology did not detect any damage during ex vivo permeation studies. Hence, in situ gel system of gellan gum may be a promising approach for nasal delivery of salbutamol sulphate for therapeutic improvement. PMID:26899173

  13. Single-stage osseointegrated implants for nasal prosthodontic rehabilitation: A clinical report.

    Science.gov (United States)

    de Carvalho, Bruna M D F; Freitas-Pontes, Karina M; de Negreiros, Wagner A; Verde, Marcus A R L

    2015-08-01

    Malignant tumors in the nasal region may be treated by means of invasive surgical procedures, with large facial losses. Nasal prostheses, retained by osseointegrated facial implants, instead of plastic surgery, will, in most patients, offer good biomechanical and cosmetic results. This clinical report describes the prosthetic rehabilitation of a patient with nasal cancer who had the entire nasal vestibule removed in a single-stage surgical procedure in order to shorten the rehabilitation time. The nasal prosthesis was built on a 3-magnet bar and was made of platinum silicone with intrinsic pigmentation, thereby restoring the patient's appearance and self-esteem. The authors concluded that single-stage implants may reduce the rehabilitation time to as little as 1 month, and the correct use of materials and techniques may significantly improve the nasal prosthesis. PMID:25976710

  14. Use of high-flow nasal cannula in neonates: Nationwide survey in Japan.

    Science.gov (United States)

    Motojima, Yukiko; Ito, Masato; Oka, Shuntaro; Uchiyama, Atsushi; Tamura, Masanori; Namba, Fumihiko

    2016-04-01

    High-flow nasal cannula is a new modality of respiratory support and is increasing in popularity despite the lack of supporting evidence. We investigated the prevalence of its use in tertiary neonatal units in Japan. A paper-based survey was conducted. The response rate was 83%. High-flow nasal cannula was used in 46/80 units (58%), of which 96% used the high-flow nasal cannula without guidelines. It was used for several indications, including weaning off nasal continuous positive airway pressure and post-extubation respiratory support. The main perceived benefits of the cannula included better access to the neonate and reduced risk of nasal trauma. This survey found that high-flow nasal cannula is used without clear criteria and that clinical practice varies across neonatal units in Japan. Its use in neonates needs to be urgently evaluated. PMID:27095676

  15. Developmental nasal midline masses in children: neuroradiological evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Huisman, Thierry A.G.M.; Schneider, Jacques F.L.; Kellenberger, Christian J.; Martin-Fiori, Ernst; Willi, Ulrich V. [Department of Radiology and Magnetic Resonance, University Children' s Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich (Switzerland); Holzmann, David [Department of Otorhinolaryngology, University Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich (Switzerland)

    2004-02-01

    Developmental nasal midline masses in children are rare lesions. Neuroimaging is essential to characterise these lesions, to determine the exact location of the lesion and most importantly to exclude a possible intracranial extension or connection. Our objective was to evaluate CT and MRI in the diagnosis of developmental nasal midline masses. Eleven patients (mean age 4.5 years) with nasal midline masses were examined by CT and MRI. Neuroimaging was evaluated for (a) lesion location/size, (b) indirect (bifid or deformed crista galli, widened foramen caecum, defect of the cribriform plate) and direct (identification of intracranially located lesion components or signal alterations) imaging signs of intracranial extension, (c) secondary complications and (d) associated malformations. Surgical and histological findings served as gold standard. Nasal dermoid sinus cysts were diagnosed in 9 patients. One patient was diagnosed with an meningocele and another patient with a nasal glioma. Indirect CT and MRI signs correlated with the surgical results in 10 of 11 patients. Direct CT findings correlated with surgery in all patients, whereas the direct MRI signs correlated in 9 of 11 patients. In 2 patients MRI showed an intracranial signal alteration not seen on CT. Neuroimaging corrected the clinical diagnosis in 1 patient. One child presented with a meningitis. In none of the patients was an associated malformation diagnosed. Intracranial extension is equally well detected by CT and MRI using indirect imaging signs. Evaluating the direct imaging signs, MRI suspected intracranial components in 2 patients without a correlate on CT. This could represent an isolated intracranial component that got undetected on CT and surgery. In 9 patients CT and MRI matched the surgical findings. The MRI did not show any false-negative results. These results in combination with the multiplanar MRI capabilities, the different image contrasts that can be generated by MRI and the lack of

  16. Astigmatic Outcomes of Temporal versus Nasal Clear Corneal Phacoemulsification

    Directory of Open Access Journals (Sweden)

    Mohammad Pakravan

    2009-04-01

    Full Text Available

    PURPOSE: To compare the astigmatic outcomes of phacoemulsification cataract surgery using temporal versus nasal clear corneal incisions. METHODS: In a clinical trial, consecutive patients with senile cataracts underwent phacoemulsification and implantation of a hydrophobic acrylic foldable intraocular lens through a horizontal clear corneal incision (temporal in right and nasal in left eyes. Outcome measures included keratometric astigmatism and surgically induced astigmatism (SIA calculated by the vector analysis method using the Holladay-Cravy-Koch formula. RESULTS: The nasal and temporal groups consisted of 20 eyes each. Mean preoperative keratometric astigmatism was 0.63±0.48 D and 0.38±0.39 D in the temporal and nasal incision groups respectively (P=0.09. Data on 10 eyes in each study group was available for the six-month analysis. Mean keratometric astigmatism was as follows in the temporal and nasal groups respectively: 0.85±0.47 D versus 1.95±0.45 D at 1 week (P < 0.001, 0.73±0.46 D versus 1.79±0.55 D at 4 weeks (P < 0.001, and 0.63±0.30 D versus 1.05±0.56 D at 6 months (P=0.053 after surgery. SIA at the same follow-up intervals was 0.71±0.20 D versus 1.80±0.22 D (P < 0.001, 0.63±0.20 D versus 1.65±0.31 D (P < 0.001 and 0.26±0.46 D versus 0.92±0.36 D (P=0.002 in the temporal versus nasal incision groups

  17. Metaplastic changes of nasal respiratory epithelium in rats exposed to hexamethylphosphoramide (HMPA) by inhalation.

    OpenAIRE

    K. P. Lee(University of Tokyo); Trochimowicz, H. J.

    1982-01-01

    Rats exposed by inhalation to hexamethylphosphoramide (HMPA) at concentrations of 50, 100, 400, and 4000 parts per billion (ppb) for 6-24 months revealed nasal tumors and squamous metaplasia with inflammation in the nasal epithelium, but no changes were observed at 10 ppb. The ciliated cells were most susceptible to HMPA, showing degenerative changes, with abnormal cilia and extensive deciliation. The desquamated nasal epithelium was repaired initially by undifferentiated mucus or microvillou...

  18. Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde.

    OpenAIRE

    Holmstrom, M.; Lund, V J

    1991-01-01

    Formaldehyde is a well known nasal carcinogen in rodents, but so far there has been no convincing evidence that workers occupationally exposed to formaldehyde have an increased risk of nasal cancer. In this study three cases of malignant melanoma of the nasal mucosa in persons occupationally exposed to formaldehyde for a long time are presented. The occurrence of such a rare tumour in patients with significant exposure to a known carcinogen warrants further investigation.

  19. IgG4-related chronic rhinosinusitis: A new clinical entity of nasal disease

    OpenAIRE

    Moteki, Hideaki; Yasuo, Masanori; Hamano, Hideaki; Uehara, Takeshi; Usami, Shin-Ichi

    2010-01-01

    Conclusion IgG4-related disease involves nasal manifestations with chronic rhinosinusitis (CRS). This type of sinusitis is a new clinical entity of nasal disease associated with a high level of serum IgG4 for which steroid therapy is effective. Objectives. To confirm whether IgG4-related disease has distinctive chronic rhinosinusitis. Methods: We compared serum IgG4 levels as well as nasal computed tomography (CT) and clinicopathological findings before and after glucocorticoid treatment in 3...

  20. Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis.

    OpenAIRE

    Braunstein, G; Malaquin, F; Fajac, I; Melac, M; Frossard, N

    1992-01-01

    This double-blind randomized crossover placebo-controlled study was designed to assess objectively the nasal antihistamine effect of cetirizine in patients with allergic rhinitis and control subjects. Nasal challenge was performed by nebulization of increasing doubling doses of histamine (0; 0.04 to 1.28 mg/nostril) in six patients with allergic rhinitis and six control subjects on cetirizine (2 x 10 mg daily for 3 days) or placebo. Sneezings were counted and nasal obstruction was assessed by...

  1. Ultrasonography in the diagnosis of nasal bone fractures: a comparison with conventional radiography and computed tomography.

    Science.gov (United States)

    Lee, In Sook; Lee, Jung-Hoon; Woo, Chang-Ki; Kim, Hak Jin; Sol, Yu Li; Song, Jong Woon; Cho, Kyu-Sup

    2016-02-01

    The purpose of this study was to evaluate and compare the diagnostic efficacy of ultrasonography (US) with radiography and multi-detector computed tomography (CT) for the detection of nasal bone fractures. Forty-one patients with a nasal bone fracture who underwent prospective US examinations were included. Plain radiographs and CT images were obtained on the day of trauma. For US examinations, radiologist used a linear array transducer (L17-5 MHz) in 24 patients and hockey-stick probe (L15-7 MHz) in 17. The bony component of the nose was divided into three parts (right and left lateral nasal walls, and midline of nasal bone). Fracture detection by three modalities was subjected to analysis. Furthermore, findings made by each modality were compared with intraoperative findings. Nasal bone fractures were located in the right lateral wall (n = 28), midline of nasal bone (n = 31), or left lateral wall (n = 31). For right and left lateral nasal walls, CT had greater sensitivity and specificity than US or radiography, and better agreed with intraoperative findings. However, for midline fractures of nasal bone, US had higher specificity, positive predictive value, and negative predictive value than CT. Although two US evaluations showed good agreements at all three sites, US findings obtained by the hockey-stick probe showed closer agreement with intraoperative findings for both lateral nasal wall and midline of nasal bone. Although CT showed higher sensitivity and specificity than US or radiography, US found to be helpful for evaluating the midline of nasal bone. Furthermore, for US examinations of the nasal bone, a smaller probe and higher frequency may be required. PMID:25749616

  2. Preparation of nanosized Fluticasone Propionate nasal spray with improved stability and uniformity

    OpenAIRE

    Dai Jiajia; Ruan Benfang H.; Zhu Ying; Liang Xianrui; Su Feng; Su Weike

    2015-01-01

    Transmucosal nasal delivery has been recognized as up-and-coming option for delivery of therapeutic compounds. However, the short residence time of the formulation within the nasal cavity coupled to its low permeability is regarded as the barrier to good bioavailability. To overcome those limitations, we developed a new formulation - nanosized Fluticasone Propionate (FP) nasal spray. High pressure homogenization (HPH) was employed to achieve effective parti...

  3. Primary intra osseous venous malformation of nasal bone: A rare case report

    OpenAIRE

    Ajit Kumar Pati; Bibhuti Bhusan Nayak; Arun Kumar Choudhury; Debesh Kumar Rout

    2014-01-01

    Primary intra osseous venous malformation with involvement of nasal bone is a rare phenomenon. Nasal bone intraosseous venous malformation on a back ground of port wine stain of face has not been reported in the available literature. We report the very rare case of intraosseous venous malformation of left nasal bone developing on a background of port wine stain of face, its diagnosis, pathology, management and review of literature.

  4. MRSA Nasal Carriage Patterns and the Subsequent Risk of Conversion between Patterns, Infection, and Death

    OpenAIRE

    Gupta, Kalpana; Martinello, Richard A.; Young, Melissa; Strymish, Judith Margery; Cho, Kelly; Lawler, Elizabeth Victoria

    2013-01-01

    Background: Patterns of methicillin-resistant S. aureus (MRSA) nasal carriage over time and across the continuum of care settings are poorly characterized. Knowledge of prevalence rates and outcomes associated with MRSA nasal carriage patterns could help direct infection prevention strategies. The VA integrated health-care system and active surveillance program provides an opportunity to delineate nasal carriage patterns and associated outcomes of death, infection, and conversion in carriage....

  5. Restorative procedures in disturbed function of the upper airways - nasal breathing

    OpenAIRE

    Mlynski, Gunter

    2005-01-01

    These days, functional rhinosurgery is almost always taken to mean the improvement of nasal airflow. However, air should not only pass through the nose without obstruction. It needs to be warmed, moistened and filtered. This requires sufficient air/mucous membrane contact by spreading airflow over the entire turbinate region, as well as regulation of nasal airway resistance and the degree of turbulence within the nasal cycle. These factors are not considered enough in the concept of functiona...

  6. Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)

    OpenAIRE

    Pringels, E

    2006-01-01

    As peptides are not suitable for oral administration, they are generally administered parenterally. Due to the disadvantages associated with parenteral delivery alternative routes of administration (buccal, nasal, pulmonal, ocular, transdermal, rectal and vaginal route) have been investigated. In the present work, the nasal route was selected as an alternative route for peptide delivery. Despite the advantages related to nasal administration, the bioavailability remains low. In Chapter 1 the ...

  7. Primary intra osseous venous malformation of nasal bone: A rare case report

    Directory of Open Access Journals (Sweden)

    Ajit Kumar Pati

    2014-01-01

    Full Text Available Primary intra osseous venous malformation with involvement of nasal bone is a rare phenomenon. Nasal bone intraosseous venous malformation on a back ground of port wine stain of face has not been reported in the available literature. We report the very rare case of intraosseous venous malformation of left nasal bone developing on a background of port wine stain of face, its diagnosis, pathology, management and review of literature.

  8. Treatment of an Extensive Maxillary Cyst Using Nasal Airway and Balloon Catheter Devices

    OpenAIRE

    Atsushi Kasamatsu; Chonji Fukumoto; Morihiro Higo; Yosuke Endo-Sakamoto; Katsunori Ogawara; Masashi Shiiba; Hideki Tanzawa; Katsuhiro Uzawa

    2014-01-01

    Introduction. Large maxillary cysts occasionally expand into the maxilla and erode the maxillary sinus and nasal cavity. The Caldwell-Luc procedure is the recommended treatment for large maxillary sinus cysts. However, it is hard to preserve the nasal space in the case of large maxillary sinus cysts that penetrate into the nasal cavity. Methods. A 22-year-old man who had large maxillary sinus cysts was referred to our department for a surgical treatment. After removing the cyst from the maxil...

  9. Flow through the nasal cavity of the spiny dogfish, Squalus acanthias

    Science.gov (United States)

    Timm-Davis, L. L.; Fish, F. E.

    2015-12-01

    The nasal cavity of spiny dogfish is a blind capsule with no internal connection to the oral cavity. Water is envisioned to flow through the cavity in a smooth, continuous flow pattern; however, this assumption is based on previous descriptions of the morphology of the olfactory cavity. No experimentation on the flow through the internal nasal cavity has been reported. Morphology of the head of the spiny dogfish ( Squalus acanthias) does not suggest a close external connection between the oral and nasal systems. However, dye visualization showed that there was flow through the nasal apparatus and from the excurrent nostril to the mouth when respiratory flows were simulated. The hydrodynamic flow through the nasal cavity was observed from flow tank experiments. The dorsum of the nasal cavity of shark heads from dead animals was exposed by dissection and a glass plate was glued over of the exposed cavity. When the head was placed in a flow, dye was observed to be drawn passively into the cavity showing a complex, three-dimensional hydrodynamic flow. Dye entered the incurrent nostril, flowed through the nasal lamellae, crossed over and under the nasal valve, and circulated around the nasal valve before exiting the excurrent nostril. When the nasal valve was removed, the dye became stagnant and back flowed out through the incurrent nostril. The single nasal valve has a hydrodynamic function that organizes a coherent flow of water through the cavity without disruption. The results suggest that the morphology of the nasal apparatus in concert with respiratory flow and ambient flows from active swimming can be used to draw water through the olfactory cavity of the shark.

  10. Freeze-dried Xanthan/Guar Gum Nasal Inserts for the Delivery of Metoclopramide Hydrochloride

    OpenAIRE

    Dehghan, Mohamed Hassan; Girase, Mohan

    2012-01-01

    Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic and effective for preventing emesis induced by cancer chemotherapy, migraine, pregnancy and gastropare...

  11. Predictive Value of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Swab PCR Assay for MRSA Pneumonia

    OpenAIRE

    Dangerfield, Benjamin; Chung, Andrew; Webb, Brandon; Seville, Maria Teresa

    2014-01-01

    Pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) is associated with poor outcomes and frequently merits empirical antibiotic consideration despite its relatively low incidence. Nasal colonization with MRSA is associated with clinical MRSA infection and can be reliably detected using the nasal swab PCR assay. In this study, we evaluated the performance of the nasal swab MRSA PCR in predicting MRSA pneumonia. A retrospective cohort study was performed in a tertiary care cente...

  12. Drop deformation in stokes flow through converging channels

    OpenAIRE

    Wrobel, LC; Soares, D.; Das Bhaumik, CL

    2009-01-01

    This work presents an application of a direct BEM formulation for drop deformation and interaction in Stokes flows through converging channels. Parametric studies are conducted to investigate the effect, on drop deformation, of the channel’s convergence ratio, the drop-fluid viscosity ratio, the interfacial tension and the initial relative position of the drops.

  13. 14 CFR 29.725 - Limit drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit drop test. 29.725 Section 29.725... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Landing Gear § 29.725 Limit drop test. The limit drop test must be conducted as follows: (a) The drop height must be at least 8 inches. (b)...

  14. 14 CFR 27.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 27.727... Reserve energy absorption drop test. The reserve energy absorption drop test must be conducted as follows: (a) The drop height must be 1.5 times that specified in § 27.725(a). (b) Rotor lift, where...

  15. 14 CFR 23.725 - Limit drop tests.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit drop tests. 23.725 Section 23.725... § 23.725 Limit drop tests. (a) If compliance with § 23.723(a) is shown by free drop tests, these tests... their proper relation, from free drop heights not less than those determined by the following formula:...

  16. 14 CFR 27.725 - Limit drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit drop test. 27.725 Section 27.725... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Landing Gear § 27.725 Limit drop test. The limit drop test must be conducted as follows: (a) The drop height must be— (1) 13 inches from the...

  17. 14 CFR 23.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 23.727... Construction Landing Gear § 23.727 Reserve energy absorption drop test. (a) If compliance with the reserve energy absorption requirement in § 23.723(b) is shown by free drop tests, the drop height may not be...

  18. 14 CFR 29.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 29.727....727 Reserve energy absorption drop test. The reserve energy absorption drop test must be conducted as follows: (a) The drop height must be 1.5 times that specified in § 29.725(a). (b) Rotor lift,...

  19. Predicting Students Drop Out: A Case Study

    Science.gov (United States)

    Dekker, Gerben W.; Pechenizkiy, Mykola; Vleeshouwers, Jan M.

    2009-01-01

    The monitoring and support of university freshmen is considered very important at many educational institutions. In this paper we describe the results of the educational data mining case study aimed at predicting the Electrical Engineering (EE) students drop out after the first semester of their studies or even before they enter the study program…

  20. Scaling the drop size in coflow experiments

    Energy Technology Data Exchange (ETDEWEB)

    Castro-Hernandez, E; Gordillo, J M [Area de Mecanica de Fluidos, Universidad de Sevilla, Avenida de los Descubrimientos s/n, 41092 Sevilla (Spain); Gundabala, V; Fernandez-Nieves, A [School of Physics, Georgia Institute of Technology, Atlanta, GA 30332 (United States)], E-mail: jgordill@us.es

    2009-07-15

    We perform extensive experiments with coflowing liquids in microfluidic devices and provide a closed expression for the drop size as a function of measurable parameters in the jetting regime that accounts for the experimental observations; this expression works irrespective of how the jets are produced, providing a powerful design tool for this type of experiments.

  1. As Fitness Levels Rise, Diabetes Risk Drops

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_158889.html As Fitness Levels Rise, Diabetes Risk Drops But change requires dedication to regular exercise in the long run, study shows ... By Robert Preidt Tuesday, May 17, 2016 TUESDAY, May 17, 2016 (HealthDay News) -- A higher level of heart-lung fitness may reduce your risk ...

  2. 49 CFR 178.965 - Drop test.

    Science.gov (United States)

    2010-10-01

    ... Large Packaging design types and performed periodically as specified in § 178.955(e) of this subpart. (b... § 178.960(d). (d) Test method. (1) Samples of all Large Packaging design types must be dropped onto a... be restored to the upright position for observation. (2) Large Packaging design types with a...

  3. Drop impact entrapment of bubble rings

    CERN Document Server

    Thoraval, M -J; Etoh, T G; Thoroddsen, S T

    2012-01-01

    We use ultra-high-speed video imaging to look at the initial contact of a drop impacting onto a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et al. [Phys. Rev. Lett. 108, 264506 (2012)]. These dynamics occur mostly within 50 {\\mu}s after the first contact, requiring imaging at 1 million frames/sec. For a water drop impacting onto a thin layer of water, the entrapment of isolated bubbles starts through azimuthal instability, which forms at low impact velocities, in the neck connecting the drop and pool. For Re above about 12 000, up to 10 partial bubble-rings have been observed at the base of the ejecta, starting when the contact is about 20% of the drop size. More regular bubble rings are observed for a pool of ethanol or methanol. The video imaging shows rotation around some of these air cylinders, which can temporarily delay their breakup into microbubbles. The different refractive index in the pool l...

  4. Utah Drop-Out Drug Use Questionnaire.

    Science.gov (United States)

    Governor's Citizen Advisory Committee on Drugs, Salt Lake City, UT.

    This questionnaire assesses drug use practices in high school drop-outs. The 79 items (multiple choice or apply/not apply) are concerned with demographic data and use, use history, reasons for use/nonuse, attitudes toward drugs, availability of drugs, and drug information with respect to narcotics, amphetamines, LSD, Marijuana, and barbiturates.…

  5. Reasons Students with Disabilities Drop Out.

    Science.gov (United States)

    Bounds, M. Betsy; Gould, Albert

    2000-01-01

    Students with disabilities who dropped out of high school (n=60) cited more school factors (lack of academic success, suspension, peer problems) than personal factors (motivation, pregnancy, family problems) influencing dropout. Three-fourths suggested improved communication with teachers, flexible scheduling, and more relevance would decrease…

  6. Potential drop sensors for sodium loops

    International Nuclear Information System (INIS)

    Potential drop sensors to detect the presence or the absence of sodium in pipe lines are described. These are very handy during loop charging and dumping operations. Their suitability to detect level surges and to monitor continuous level of liquid metals in certain applications is discussed. (author)

  7. An evaporation model of multicomponent solution drops

    Science.gov (United States)

    Sartori, Silvana; Liñán, Amable; Lasheras, Juan C.

    2010-11-01

    Solutions of polymers are widely used in the pharmaceutical industry as tablets coatings. These allow controlling the rate at which the drug is delivered, taste or appearance. The coating is performed by spraying and drying the tablets at moderate temperatures. The wetting of the coating solution on the pill's surface depends on the droplet Webber and Re numbers, angle of impact and on the rheological properties of the droplet. We present a model for the evaporation of multicomponent solutions droplets in a hot air environment with temperatures substantially lower than the boiling temperature of the solvent. As the liquid vaporizes from the surface the fluid in the drop increases in concentration, until reaching its saturation point. After saturation, precipitation occurs uniformly within the drop. As the surface regresses, a compacting front formed by the precipitate at its maximum packing density advances into the drop, while the solute continues precipitating uniformly. This porous shell grows fast due to the double effect of surface regression and precipitation. The evaporation rate is determined by the rates at which heat is transported to the droplet surface and at which liquid vapor diffuses away from it. When the drop is fully compacted, the evaporation is drastically reduced.

  8. Merocel versus Nasopore for nasal packing: a meta-analysis of randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Jianzhang Wang

    Full Text Available OBJECTIVE: To compare the clinical outcomes, including efficacy and complications, of Merocel versus Nasopore as a nasal packing material after nasal surgery. METHODS: Relevant randomized controlled trials were identified from electronic databases (The Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure and Chinese Biomedical Database. Conference proceedings and references from identified trials and review articles were also searched. Outcome measures were pain during nasal packing, pain and bleeding upon packing removal, pressure sensation, nasal blockage, formation of synechiae, mucosal healing, and patients' general satisfaction. RESULTS: Seven randomized controlled trials met criteria for analysis. Compared with Merocel, Nasopore significantly reduced patients' subjective symptoms including in situ pain (pain experienced while packing is in place, nasal pressure, pain and bleeding during packing removal, and increased patients' general satisfaction with nasal packing. There were no significant differences in nasal obstruction, adhesion and mucosal healing between the Merocel and Nasopore groups. CONCLUSIONS: Preliminary evidence suggests that Nasopore may be superior to Merocel as a nasal packing material with regard to in situ pain, pain and bleeding upon removal, pressure, and general satisfaction and does not differ from Merocel in terms of nasal obstruction, tissue adhesion, and long-term mucosal healing.

  9. Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole

    International Nuclear Information System (INIS)

    An 11-year-old, spayed female keeshond was presented for unilateral epistaxis and serous nasal discharge of four weeks duration. Initial nasal radiographs, rhinoscopy, and histopathology suggested severe, destructive lymphoplasmacytic rhinitis. The patient deteriorated while receiving an anti-inflammatory dose of prednisone. A computed tomographic scan of the nose demonstrated a soft-tissue density in both the right nasal cavity and frontal sinus. Samples for histopathology obtained at surgery were diagnostic for nasal aspergillosis. All clinical signs resolved with a single, noninvasive infusion of intranasal clotrimazole and a four-week course of oral itraconazole

  10. Nasal base narrowing of the caucasian nose through the cerclage technique

    Directory of Open Access Journals (Sweden)

    Mocellin, Marcos

    2010-06-01

    Full Text Available Introduction: Several techniques can be performed to reduce the nasal base (narrowing, as skin resection vestibular columellar skin resection, resection of skin in elliptical lip narinary, sloughing of skin and advancements (VY technique of Bernstein and the use of cerclage sutures in the nasal base. Objective: To evaluate the technique of cerclage performed in the nasal base, through endonasal rhinoplasty without delivery of basic technique, in the Caucasian nose, reducing the distance inter-alar flare and correcting the wing with consequent improvement in nasal harmony in the whole face. Methods: A retrospective analysis by analysis of clinical documents and photos of 43 patients in whom cerclage was made of the nasal base by resecting skin ellipse in the region of the vestibule and the nasal base (modified technique of Weir using colorless mononylon® 4 "0" with a straight cutting needle. The study was conducted in 2008 and 2009 at Hospital of Paraná Institute of Otolaryngology - IPO in Curitiba, Parana - Brazil. Patients had a follow up ranging 7-12 months. Results: In 100% of cases was achieved an improvement in nasal harmony, by decreasing the inter-alar distance. Conclusion: The encircling with minimal resection of vestibular skin and the nasal base is an effective method for the narrowing of the nasal base in the Caucasian nose, with predictable results and easy to perform.

  11. In vivo deposition of ultrafine aerosols in human nasal and oral airways

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, Hsu-Chi; Swift, D.L. [John Hopkins Univ., Baltimore, MD (United States); Simpson, S.Q. [Univ. of New Mexico, Albuquerque, NM (United States)] [and others

    1995-12-01

    The extrathoracic airways, including the nasal passage, oral passage, pharynx, and larynx, are the first targets for inhaled particles and provide an important defense for the lung. Understanding the deposition efficiency of the nasal and oral passages is therefore crucial for assessing doses of inhaled particles to the extrathoracic airways and the lung. Significant inter-subject variability in nasal deposition has been shown in recent studies by Rasmussen, T.R. et al, using 2.6 {mu}m particles in 10 human subjects and in our preliminary studies using 0.004-0.15 {mu}m particles in four adult volunteers. No oral deposition was reported in either of these studies. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. The aims of the present study were to measure in vivo the nasal airway dimensions and the deposition of ultrafine aerosols in both the nasal and oral passages, and to determine the relationship between nasal airway dimensions and aerosol deposition. A statistical procedure incorporated with the diffusion theory was used to model the dimensional features of the nasal airways which may be responsible for the biological variability in particle deposition. In summary, we have correlated deposition of particles in the size range of 0.004 to 0.15 {mu}m with the nasal dimensions of each subject.

  12. Pneumocephalus after insertion of an inflatable nasal tampon for the management of epistaxis.

    Science.gov (United States)

    Kimple, Adam J; Ferguson, Michael O

    2016-01-01

    While the fundamental principles of epistaxis management have not changed over the decades, the methods by which tamponade is achieved have been evolving. Inflatable nasal tampons are being used and seen with increasing frequency in our ENT clinic. They are usually placed by emergency department personnel, who then refer patients to our clinic for removal. The classically described complications of nasal packs are induction of the nasopulmonary reflex, toxic shock syndrome, and discomfort. In this article, we describe a case of pneumocephalus following placement of an inflatable nasal tampon. To the best of our knowledge, this is the first report of pneumocephalus after placement of an inflatable nasal tampon. PMID:27140017

  13. In vivo deposition of ultrafine aerosols in human nasal and oral airways

    International Nuclear Information System (INIS)

    The extrathoracic airways, including the nasal passage, oral passage, pharynx, and larynx, are the first targets for inhaled particles and provide an important defense for the lung. Understanding the deposition efficiency of the nasal and oral passages is therefore crucial for assessing doses of inhaled particles to the extrathoracic airways and the lung. Significant inter-subject variability in nasal deposition has been shown in recent studies by Rasmussen, T.R. et al, using 2.6 μm particles in 10 human subjects and in our preliminary studies using 0.004-0.15 μm particles in four adult volunteers. No oral deposition was reported in either of these studies. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. The aims of the present study were to measure in vivo the nasal airway dimensions and the deposition of ultrafine aerosols in both the nasal and oral passages, and to determine the relationship between nasal airway dimensions and aerosol deposition. A statistical procedure incorporated with the diffusion theory was used to model the dimensional features of the nasal airways which may be responsible for the biological variability in particle deposition. In summary, we have correlated deposition of particles in the size range of 0.004 to 0.15 μm with the nasal dimensions of each subject

  14. Clara cell protein in nasal lavage fluid and nasal nitric oxide - biomarkers with anti-inflammatory properties in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Irander Kristina

    2012-02-01

    Full Text Available Abstract Background Clara cell protein (CC16 is ascribed a protective and anti-inflammatory role in airway inflammation. Lower levels have been observed in asthmatic subjects as well as in subjects with intermittent allergic rhinitis than in healthy controls. Nasal nitric oxide (nNO is present in high concentrations in the upper airways, and considered a biomarker with beneficial effects, due to inhibition of bacteria and viruses along with stimulation of ciliary motility. The aim of this study was to evaluate the presumed anti-inflammatory effects of nasal CC16 and nNO in subjects with allergic rhinitis. Methods The levels of CC16 in nasal lavage fluids, achieved from subjects with persistent allergic rhinitis (n = 13, intermittent allergic rhinitis in an allergen free interval (n = 5 and healthy controls (n = 7, were analyzed by Western blot. The levels of nNO were measured by the subtraction method using NIOX®. The occurrences of effector cells in allergic inflammation, i.e. metachromatic cells (MC, mast cells and basophiles and eosinophils (Eos were analyzed by light microscopy in samples achieved by nasal brushing. Results The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02 in allergic subjects. The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03 and nNO (p = 0.05 were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC. Similar relationships, but not reaching significance, were observed between the CC16 and nNO levels and Eos occurrence. The levels of CC16 and nNO did not differ between the allergic and the control groups. Conclusions The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of

  15. Numerical investigation of the influence of companion drops on drop-on-demand ink jetting

    Institute of Scientific and Technical Information of China (English)

    Hai-yun ZHANG; Jin WANG; Guo-dong LU

    2012-01-01

    In this study we characterized and investigated the specific phenomenon of “companion drops” in the drop-ondemand (DOD) ink jetting process.A series of simulations based on a piezoelectric DOD printhead system is presented,adapting the volume-of-fluid (VOF) interface-capturing method to track the boundary evolution and model the interfacial physics.The results illustrate the causality between the generation of companion drops and droplet deviation behavior,as well as their close correlations with ink jetting straightness and printing accuracy.The characteristics of companion drops are summarized and compared with those of satellite drops.Also,a theoretical mechanism for the generation of companion drops is presented,and their effects and behaviors are analyzed and discussed.Finally,the effects of critical factors on the generation of companion drops are investigated and characterized based on variations in the printable pressure range.Recommendations are given for the suppression of companion drops and for the improvement of printing accuracy.

  16. Nasal NK/T cell lymphoma presents with long-term nasal blockage and fever: a rare case report and literature review

    Science.gov (United States)

    Zou, Hai; Pan, Ke-Hua; Wu, Liang; Pan, Hong-Ying; Ding, Ya-Hui; Zheng, Ming-Hua

    2016-01-01

    NK/T cell lymphoma (NKTCL) is a common disease which is a threat to human health. Nasal NKTCL is a rare but serious type of systemic lymphoma because of its high mortality rate and serious complications. In this case report, we describe a male who presented with nasal blockage in the right side, a fever of one month duration and a soy-like, painless and gradually increasing mass in the right submandibular region due to nasal NKTCL. The patient had no significant medical history and the initial clinical symptoms were nasal blockage. Contrast computed tomography showed that the nasopharyngeal mucosa was thickened and that the celiac and retroperitoneal lymphaden was intumescent. Finally a biopsy, guided by nasal endoscopy and examined using flow cytometry confirmed a diagnosis of NKTCL. Nasal NKTCL is rare and has no unique characteristics at first presentation, such as epidemiology and obvious clinical manifestation. As no effective therapy is currently available for this disease, early diagnosis and therapy of nasal NKTCL remains challenging. PMID:26885897

  17. Predictors of Nasal Obstruction: Quantification and Assessment Using Multiple Grading Scales

    Science.gov (United States)

    Camacho, Macario; Zaghi, Soroush; Certal, Victor; Abdullatif, Jose; Modi, Rahul; Sridhara, Shankar; Tolisano, Anthony M.; Chang, Edward T.; Cable, Benjamin B.; Capasso, Robson

    2016-01-01

    Objective. To evaluate the association between nasal obstruction and (1) demographic factors, (2) medical history, (3) physical tests, and (4) nasal exam findings. Study Design. Case series. Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1 ± 17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE) score of 32.0 ± 24.1) were included. Demographic factors and inferior turbinate sizes were not associated with NOSE score or Nasal Obstruction Visual Analog Scale (NO-VAS). A significant association was found between higher NOSE score on univariate analysis and positive history of nasal trauma (p = 0.0136), allergic rhinitis (p < 0.0001), use of nasal steroids (p = 0.0108), higher grade of external nasal deformity (p = 0.0149), higher internal nasal septal deviation grade (p = 0.0024), and narrow internal nasal valve angle (p < 0.0001). Multivariate analysis identified the following as independent predictors of high NOSE score: NO-VAS: ≥50 (Odds Ratio (OR) = 17.6 (95% CI 5.83–61.6), p < 0.0001), external nasal deformity: grades 2–4 (OR = 4.63 (95% CI 1.14–19.9), p = 0.0339), and allergic rhinitis: yes (OR = 5.5 (95% CI 1.77–18.7), p = 0.0041). Conclusion. Allergic rhinitis, NO-VAS score ≥ 50, and external nasal deformity (grades 2–4) were statistically significant independent predictors of high NOSE scores on multivariate analysis. Inferior turbinate size was not associated with NOSE scores or NO-VAS.

  18. Predictors of Nasal Obstruction: Quantification and Assessment Using Multiple Grading Scales

    Directory of Open Access Journals (Sweden)

    Macario Camacho

    2016-01-01

    Full Text Available Objective. To evaluate the association between nasal obstruction and (1 demographic factors, (2 medical history, (3 physical tests, and (4 nasal exam findings. Study Design. Case series. Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1±17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE score of 32.0±24.1 were included. Demographic factors and inferior turbinate sizes were not associated with NOSE score or Nasal Obstruction Visual Analog Scale (NO-VAS. A significant association was found between higher NOSE score on univariate analysis and positive history of nasal trauma (p=0.0136, allergic rhinitis (p<0.0001, use of nasal steroids (p=0.0108, higher grade of external nasal deformity (p=0.0149, higher internal nasal septal deviation grade (p=0.0024, and narrow internal nasal valve angle (p<0.0001. Multivariate analysis identified the following as independent predictors of high NOSE score: NO-VAS: ≥50 (Odds Ratio (OR = 17.6 (95% CI 5.83–61.6, p<0.0001, external nasal deformity: grades 2–4 (OR = 4.63 (95% CI 1.14–19.9, p=0.0339, and allergic rhinitis: yes (OR = 5.5 (95% CI 1.77–18.7, p=0.0041. Conclusion. Allergic rhinitis, NO-VAS score ≥ 50, and external nasal deformity (grades 2–4 were statistically significant independent predictors of high NOSE scores on multivariate analysis. Inferior turbinate size was not associated with NOSE scores or NO-VAS.

  19. Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Mohamed Yousif Atia

    2008-10-01

    Full Text Available Nasal carriage of staphylococcus aureus (S.aureus exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done, skin prick test, nasal culture for S.aureus, nasal interleukin 4,nasal total IgE, serum total IgE and serum specific IgE(SSIgE for HDM. Nasal S.aureus was detected in 16/20 patients (80% and 5/20 (25% in healthy subjects with highly significant statistical difference plt0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r = 0.78, plt0.01 and significant positive correlation with SSIgE (HDM (r = 0.53, plt0.05, nasal total IgE (r = 0.39, plt0.05 and nasal IL-4 (r = 0.55, plt0.05. Nasal staph.aureus actively modulated the immune reaction in persistent allergic rhinitis patients by promoting local IgE production, so we recommend early detection and treatment of S.aureus carriage in patients

  20. Coalescence collision of liquid drops I: Off-center collisions of equal-size drops

    Directory of Open Access Journals (Sweden)

    Alejandro Acevedo-Malavé

    2011-09-01

    Full Text Available The Smoothed Particle Hydrodynamics method (SPH is used here to model off-center collisions of equal-size liquid drops in a three-dimensional space. In this study the Weber number is calculated for several conditions of the droplets dynamics and the velocity vector fields formed inside the drops during the collision process are shown. For the permanent coalescence the evolution of the kinetic and internal energy is shown and also the approaching to equilibrium of the resulting drop. Depending of the Weber number three possible outcomes for the collision of droplets is obtained: permanent coalescence, flocculation and fragmentation. The fragmentation phenomena are modeled and the formation of small satellite drops can be seen. The ligament that is formed follows the “end pinching” mechanism and it is transformed into a flat structure.

  1. DOES BODY MASS INDEX INFLUENCE NASAL MUCOCILIARY CLEARANCE?

    Directory of Open Access Journals (Sweden)

    Tamilselvan K, Latha R, Nirmala N, Susiganeshkumar E, Thananjayam A

    2015-01-01

    Full Text Available Background: The respiratory system is constantly exposed to particulate matter suspended in the inhaled air and one among the efficient mechanisms to trap and expel the particulate substances is the nasal and bronchial mucociliary clearance mechanism. This mucociliary clearance mechanism is influenced by both physiological and pathological factors that alter the functioning of the respiratory cilia and the overlying mucosal layer that traps the particulate agents. As Body mass index (BMI determines the health of a person by influencing various physiological parameters, this study has been planned to study the effect of normal and abnormal BMI (overweight and obese range on the nasal mucociliary clearance (NMC. Aim: To evaluate the effect of BMI on nasal mucociliary clearance (NMC. Materials & Methods: NMC was measured in 20 volunteers with normal BMI (18.5-22.9 Kg/m2 and 20 volunteers with BMI in overweight and obese range (23 Kg/m2 and above. The NMC time was recorded by the time the volunteers appreciated the sweet taste following the placement of ¼ of saccharin tablet (1mm x 1mm in the nostril referred as saccharin transit time (STT.Results: NMC was found to be prolonged in overweight and obese population and BMI has positive correlation with NMC as calculated by Pearson correlation with r value of 0.591 and p value 0.001 which is statistically significant. Conclusion: NMC time is prolonged in abnormal BMI referring to the impairment in the mucociliary escalator mechanism thus predisposing to disease states.

  2. Local IgE production in nonatopic nasal polyposis.

    LENUS (Irish Health Repository)

    Sheahan, Patrick

    2012-02-01

    INTRODUCTION: Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents an eosinophilic T-helper 2 inflammatory response. Local production of IgE within nasal polyps (NPs) has been demonstrated, suggesting a role for local IgE in the pathogenesis of NP in atopic CRS patients. We hypothesized that local IgE specific to inhalant allergens may also play a role in the genesis of NP in nonatopic CRS patients. METHODS: Sinus and inferior turbinate tissue was obtained from nonatopic CRSwNP patients (n = 7), chronic rhinosinusitis without nasal polyps (CRSsNP) patients (n = 15), and healthy controls (n = 9) at the time of surgery. ImmunoCAP analysis (Phadia AB, Portage, MI) for 14 common inhalant antigens was performed on tissue homogenates to determine the antigen-specific response. RESULTS: Total IgE levels did not differ in sinus or turbinate tissue between CRSwNP, CRSsNP, or control patients. CRSwNP sinus tissue had higher levels of specific IgE for cockroach and plantain (p = .03) than other groups and elevated Alternaria IgE levels when compared with CRSsNP sinus tissue (p < .05). No significant differences were found for any of the other antigen-specific IgE levels. Fifty-seven percent of CRSwNP polyps demonstrated a polyclonal IgE response, whereas the other 43% had no demonstrable antigen-specific IgE. In contrast, only 17% of CRSsNP patients demonstrated a polyclonal response within sinus tissue, whereas 67% had no detectable antigen-specific IgE. There was no significant difference in levels of IgE in inferior turbinate tissue between the groups (p > .05). CONCLUSIONS: Localized mucosal IgE specific to common inhalant allergens appears to play a role in a subset of CRSwNP patients without evidence of systemic atopy.

  3. Stable Dry Powder Formulation for Nasal Delivery of Anthrax Vaccine

    OpenAIRE

    Wang, Sheena H.; Kirwan, Shaun M.; Abraham, Soman N.; Staats, Herman F.; Hickey, Anthony J.

    2011-01-01

    There is a current biodefense interest in protection against Anthrax. Here we developed a new generation of stable and effective anthrax vaccine. We studied the immune response elicited by rPA delivered intranasally with a novel mucosal adjuvant, a mast cell activator Compound 48/80. The vaccine formulation was prepared in a powder form by spray-freeze-drying (SFD) under optimized conditions to produce particles with a target size of D50=25μm, suitable for delivery to the rabbit nasal cavity....

  4. Fungal Agents as a Cause of Nasal Polyposis

    Directory of Open Access Journals (Sweden)

    Mohammad Nejadkazem

    2015-01-01

    Full Text Available Introduction: Sinonasal polyposis is the most common tumor of nasal cavity and sinuses. Its complications are but not limited to sinusitis, breathing difficulties, hyposmia, anosmia and bone erosion.Methods and materials: A total of 98 patients with sinonasal polyposis were examined for suspicious causative fungal agent.Results: Direct microscopy and culture confirmed fungal agent in 8 patients (8.1% from which 3 cases had Alternaria spp, 1 patient Aspergillus spp, 1 patient Bipolaris spp, and 3 patients yeast.Conclusion: Fungi may be considered as a potential cause of sinonasal polyposis. Keywords: Sinonasal Polyposis, Rhinosinusitis, Fungi

  5. Aplicaciones del colgajo frontonasal para la cobertura de defectos nasales

    Directory of Open Access Journals (Sweden)

    M. Pérez

    2015-12-01

    Full Text Available Presentamos una revisión retrospectiva de los pacientes a los cuales se realizó un colgajo frontonasal para la cobertura de defectos nasales intervenidos en la Unidad de Tumores Cutáneos de nuestro Servicio en el periodo comprendido entre enero de 2010 y mayo de 2014. El objetivo es analizar nuestras aplicaciones y resultados además de describir un algoritmo que permita indicar los distintos diseños en función de la localización y el tamaño del defecto a reparar. Empleamos el colgajo frontonasal en 78 pacientes (49 mujeres y 29 varones con un rango de edad de 47 a 92 años (media de 73 años. Creamos un total de 81 defectos, puesto que en 3 casos se resecaron simultáneamente 2 tumoraciones, todos de etiología tumoral (64 carcinomas basocelulares, 16 carcinomas espinocelulares y 1 caso de léntigo maligno melanoma, localizados en el área nasal, con un tamaño mínimo de 12 x 17 mm y máximo de 30 x 35 mm (media de 22 x 25 mm. El periodo de seguimiento fue de entre 2 meses y 4 años (media de 2,5 años. Respecto a las complicaciones observadas, todas ellas menores, hubo 6 casos de necrosis marginal, 8 de dehiscencia parcial de la herida y 1 de cicatrización hipertrófica, tratándose en su mayor parte de varones fumadores. Todos los colgajos sobrevivieron con resultado estético satisfactorio. El colgajo frontonasal permite la cobertura en un sólo tiempo quirúrgico de defectos nasales independientemente de su localización, de hasta 30 x 35 mm en nuestra serie. Se trata de un colgajo seguro y versátil en sus múltiples modificaciones, con unos resultados estéticos satisfactorios. Estas ventajas son de especial importancia en pacientes de edad avanzada como alternativa a técnicas más complejas. Se trata por lo tanto, a nuestro juicio, de una opción a tener en cuenta para la reconstrucción en un único tiempo quirúrgico de defectos nasales.

  6. The Tolerance of the Nasal Bone to Blunt Impact

    OpenAIRE

    Cormier, Joseph; Manoogian, Sarah; Bisplinghoff, Jill; Rowson, Steve; Santago, Anthony; McNally, Craig; Duma, Stefan; Bolte, John

    2010-01-01

    The nasal bone is among the most frequently broken facial bone due to all types of trauma and is the most frequently fractured facial bone due to motor vehicle collisions. This study reports the results of anterior-posterior impacts performed on male cadavers using a free-falling impactor with a flat impacting surface. The force at fracture onset was determined using an acoustic emission sensor. These non-censored data were utilized in parametric and non-parametric techniques to determine a r...

  7. Nasal Potential Difference in Cystic Fibrosis considering Severe CFTR Mutations

    OpenAIRE

    2015-01-01

    The gold standard for diagnosing cystic fibrosis (CF) is a sweat chloride value above 60 mEq/L. However, this historical and important tool has limitations; other techniques should be studied, including the nasal potential difference (NPD) test. CFTR gene sequencing can identify CFTR mutations, but this method is time-consuming and too expensive to be used in all CF centers. The present study compared CF patients with two classes I-III CFTR mutations (10 patients) (G1), CF patients with class...

  8. Decreased Expression of FOXP3 in Nasal Polyposis

    OpenAIRE

    Roongrotwattanasiri, Kannika; Pawankar, Ruby; KIMURA, SATOKO; Mori, Sachiko; Nonaka, Manabu; Yagi, Toshiaki

    2011-01-01

    Purpose The pathogenesis of nasal polyposis (NP) is unclear. Eosinophils and mast cells are considered to play important roles in this process. In addition, the levels of Th2-type cells are increased, irrespective of the atopic status of the patient with NP. In this context, we and others have shown high levels of thymus and activation-related chemokine/CCL17, macrophage-derived chemokine, eotaxin, and RANTES in patients with NP. Forkhead box P3 (FOXP3) plays a key role in CD4+CD25+ regulator...

  9. Preparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Delivery.

    Science.gov (United States)

    Barbi, Mariana Da Silva; Carvalho, Flávia Chiva; Kiill, Charlene Priscila; Barud, Hernane Da Silva; Santagneli, Sílvia Helena; Ribeiro, Sidney José Lima; Gremião, Maria Palmira Daflon

    2015-01-01

    Zidovudine (AZT) is the antiretroviral drug most frequently used for the treatment of Acquired Immunodeficiency Syndrome. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. The nasal route is an option for enhanced therapeutic efficacy and to reduce the extent of the first-pass effect. In this article, AZT loaded chitosan nanoparticles were prepared by a modified ionotropic gelation method with sodium tripolyphosphate. The increase proportion of CS (NP1 10:01 (w/w)) promoted the formation of smaller nanoparticles (260 nm), while raising the proportion of TPP (NP2 5:1 w/w) increased the nanoparticles size (330 nm). The incorporation of AZT increased the nanoparticles size for both AZT-loaded nanoparticles AZT-loaded NP1 (406 nm) and AZT-loaded NP2 (425 nm). The incorporation of AZT into NP1 did not change the electrophoretic mobility, however, in AZT-loaded NP2 there was a significant increase. The positive surface of the nanoparticles is very important for the mucoadhesive properties due interaction with the sialic groups of the mucin. Nuclear resonance magnetic data showed that the higher concentration of chitosan in the nanoparticles favored the interaction of few phosphate units (pyrophosphate) by ionic interaction Scanning electron microscopy, revealed that the nanoparticles are nearly spherical shape with porous surface. The entrapment efficiency of AZT, was 17.58% ± 1.48 and 11.02% ± 2.05 for NP1 and NP2, respectively. The measurement of the mucoadhesion force using mucin discs and nasal tissue obtained values of NP1 = 2.12 and NP2 = 4.62. In vitro permeation study showed that the nanoparticles promoted an increase in the flux of the drug through the nasal mucosa. In view of these results, chitosan nanoparticles were found to be a promising approach for the incorporation of hydrophilic drugs and these results suggest that the CS-containing nanoparticles have great potential for nasal AZT

  10. Nasal airway nitric oxide : Methodological aspects and influence of inflammation

    OpenAIRE

    Palm, Jörgen

    2004-01-01

    Nitric oxide (NO) is an endogenously formed free radical gas involved in numerous biological processes. In 1991 NO was discovered to be present in exhaled air of humans. Soon after, it was reported that the largest amounts of NO were found in the upper airways, and that the levels of NO were increased in the lower airways of patients with asthma. The high levels of NO in the nasal region are believed to be involved in functions as various as primary host defence, including k...

  11. Nasal highflow improves ventilation in patients with COPD

    Directory of Open Access Journals (Sweden)

    Bräunlich J

    2016-05-01

    Full Text Available Jens Bräunlich,* Marcus Köhler,* Hubert WirtzDepartment of Respiratory Medicine, University of Leipzig, Leipzig, Germany *These authors contributed equally to this workBackground: Nasal highflow (NHF provides a warmed and humidified air stream up to 60 L/min. Recent data demonstrated a positive effect in patients with acute hypoxemic respiratory failure, especially when caused by pneumonia. Preliminary data show a decrease in hypercapnia in patients with COPD. Therefore, NHF should be evaluated as a new ventilatory support device. This study was conducted to assess the impact of different flow rates on ventilatory parameters in patients with COPD.Materials and methods: This interventional clinical study was performed with patients suffering from severe COPD. The aim was to characterize flow-dependent changes in mean airway pressure, breathing volumes, breathing frequency, and decrease in partial pressure of CO2 (pCO2. Mean airway pressure was measured in the nasopharyngeal space (19 patients. To evaluate breathing volumes, we used a polysomnographic device (18 patients. All patients received 20 L/min, 30 L/min, 40 L/min, and 50 L/min and – to illustrate the effects – nasal continuous positive airway pressure and nasal bilevel positive airway pressure. Capillary blood gas analyses were performed in 54 patients with hypercapnic COPD before and two hours after the use of NHF. We compared the extent of decrease in pCO2 when using 20 L/min and 30 L/min. Additionally, comfort and dyspnea during the use of NHF were surveyed.Results: NHF resulted in a minor flow dependent increase in mean airway pressure. Tidal volume increased, and breathing rate decreased. The calculated minute volume decreased under NHF breathing. In spite of this fact, hypercapnia decreased with increasing flow (20 L/min vs 30 L/min. Additionally, an improvement in dyspnea was observed. The rapid shallow breathing index shows a decrease when using NHF.Conclusion: NHF

  12. Sensitive analysis of fuel drop diameter in vapor explosions

    International Nuclear Information System (INIS)

    Background: In nuclear plant vapor explosion analysis, fuel drop diameter is an important parameter which could significantly influence the evaluation of explosion pressure. Purpose: Decrease the uncertainty of vapor explosion calculation caused by fuel drop diameter. Methods: A simulation model of typical vapor explosion was built using MC3D to take sensitive analysis of fuel drop diameter. Results: The calculation relates to fuel drop energy, fuel drop fragmentation rate and vapor explosion pressure. The effect of fuel drop diameter in vapor explosion is analyzed based on theoretical analysis and the calculation. Conclusions: The results show that the vapor explosion pressure is very sensitive to fuel drop diameter, which is mainly caused by the fuel drop energy and the fuel drop fragmentation rate. (authors)

  13. A pressure drop model for PWR grids

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dong Seok; In, Wang Ki; Bang, Je Geon; Jung, Youn Ho; Chun, Tae Hyun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-12-31

    A pressure drop model for the PWR grids with and without mixing device is proposed at single phase based on the fluid mechanistic approach. Total pressure loss is expressed in additive way for form and frictional losses. The general friction factor correlations and form drag coefficients available in the open literatures are used to the model. As the results, the model shows better predictions than the existing ones for the non-mixing grids, and reasonable agreements with the available experimental data for mixing grids. Therefore it is concluded that the proposed model for pressure drop can provide sufficiently good approximation for grid optimization and design calculation in advanced grid development. 7 refs., 3 figs., 3 tabs. (Author)

  14. Discrete Element Modeling of Drop Tests

    Science.gov (United States)

    Wang, Yuannian; Tonon, Fulvio

    2012-09-01

    A discrete element code with impact model has been developed and calibrated to simulate the dynamic behavior of rock materials, with special regard to rock fragmentation upon impact during rock-fall analysis. The paper summarizes the discrete element code, the calibration algorithms developed to identify the model microparameters, and the impact model. Experimental work on drop tests is then used to validate the code on modeling impact fragmentation. It has been found that the developed discrete element code and impact model can reasonably simulate rock fragmentation in drop tests. The use of the discrete element code and impact model can provide good reference results in evaluating impact fragmentation in rock-fall analysis.

  15. Drop evaporation and triple line dynamics

    Science.gov (United States)

    Sobac, Benjamin; Brutin, David; Gavillet, Jerome; Université de Provence Team; Cea Liten Team

    2011-03-01

    Sessile drop evaporation is a phenomenon commonly came across in nature or in industry with cooling, paintings or DNA mapping. However, the evaporation of a drop deposited on a substrate is not completely understood due to the complexity of the problem. Here we investigate, with several nano-coating of the substrate (PTFE, SiOx, SiOc and CF), the influence of the dynamic of the triple line on the evaporation process. The experiment consists in analyzing simultaneously the motion of the triple line, the kinetics of evaporation, the internal thermal motion and the heat and mass transfer. Measurements of temperature, heat-flux and visualizations with visible and infrared cameras are performed. The dynamics of the evaporative heat flux appears clearly different depending of the motion of the triple line

  16. Coupling slots without shunt impedance drop

    International Nuclear Information System (INIS)

    It is well known that coupling slots between adjacent cells in a π-mode structure reduce shunt impedance per unit length with respect to single cell cavities. To design optimized coupling slots, one has to answer the following question: for a given coupling factor, what shape, dimension, position and number of slots lead to the lowest shunt impedance drop? A numerical study using the 3D code MAFIA has been carried out. The aim was to design the 352 MHz cavities for the high intensity proton accelerator of the TRISPAL project. The result is an unexpected set of four 'petal' slots. Such slots should lead to a quasi-negligible drop in shunt impedance: about -1% on average, for particle velocity from 0.4 c to 0.8 c. (author)

  17. Control of Drop Motion by Mechanical Vibrations

    Science.gov (United States)

    Bestehorn, Michael

    2014-11-01

    Since the first experimental observations of Michael Faraday in 1831 it is known that a vibrating liquid may show an instability of its flat free surface with respect to oscillating regular surface patterns. We study thin liquid films on a horizontal substrate in the long wave approximation. The films are parametrically excited by mechanical horizontal or inclined oscillations. Inertia effects are taken into account and the standard thin film formulation is extended by a second equation for the vertically averaged mass flux. The films can be additionally unstable by Van der Waals forces on a partially wetting substrate, leading to the formation of drops. These drops can be manipulated by the vibrations to move in a desired direction. Linear results based on a damped complex valued Mathieu equation as well as fully nonlinear results using a reduced model will be presented, for more details see.

  18. SURVEY OF PACKET DROPPING ATTACK IN MANET

    Directory of Open Access Journals (Sweden)

    A.Janani

    2014-03-01

    Full Text Available Mobile Ad-hoc NETwork (MANET is an application of wireless network with self-configuring mobile nodes. MANET does not require any fixed infrastructure. Its development never has any threshold range. Nodes in MANET can communicate with each other if and only if all the nodes are in the same range. This wide distribution of nodes makes MANET vulnerable to various attacks, packet dropping attack or black hole attack is one of the possible attack. It is very hard to detect and prevent. To prevent from packet dropping attack, detection of misbehavior links and selfish nodes plays a vital role in MANETs. In this paper, a omprehensive investigation on detection of misbehavior links and malicious nodes is carried out.

  19. Drop test of transportable storage cask

    International Nuclear Information System (INIS)

    It is being planned to transport the transportable storage casks again after their storage period of several decades, so metal gaskets are used as seal material in their lids in place of rubber o-rings which deteriorate during the storage period. Since the slightest dislocation of the lids causes seal performance deterioration in the metal gaskets, it is necessary to establish a simulation technology which accurately estimates the dislocation in order to design a rigid lid structure to protect against the impact loads under 9 m drop condition. A 1:3 scale model of the transportable storage cask developed by Hitz for BWR spent fuel rods were manufactured and 9 m drop tests were performed. Measured dislocations of the lids were confirmed within the allowable limit and they were found to be accurately simulated. (author)

  20. Dropped nucleus following phacoemulsification cataract surgery.

    Science.gov (United States)

    Tajunisah, I; Reddy, S C

    2007-12-01

    Twenty two cases of dropped nucleus following 1,196 phacoemulsification procedures in cataract surgery were examined retrospectively to determine the incidence, predisposing factors and visual outcomes of this dreaded complication. All the cases underwent pars plana vitrectomy and the lens fragments were removed with phacofragmotome, vitrectomy cutter or delivered through limbus. The incidence of dropped nucleus was 1.84%. The predisposing factors were hard cataracts (13.6%), polar cataracts (9.1%), previously vitrectomized eyes (4.5%) and high myopia (4.5%). The final visual outcome was > or = 6/12 in 10 eyes (45.5%); complications were seen in 5 eyes (22.7%). The interval between initial surgery and vitrectomy, the method of fragment removal and the type of lens implanted, did not influence the final visual outcome. PMID:18705466

  1. Tolerability and effects on quality of life of liposomal nasal spray treatment compared to nasal ointment containing dexpanthenol or isotonic NaCl spray in patients with rhinitis sicca

    OpenAIRE

    Hahn, C; Böhm, M.; Allekotte, S.; Mösges, R

    2013-01-01

    This study aimed to investigate symptom reduction via the liposomal nasal spray LipoNasal (LN) in patients with rhinitis sicca. Tolerability and the impact on quality of life were also examined. The same parameters were established in parallel for treatment approaches with Bepanthen (BP) nasal ointment containing dexpanthenol and the Rhinomer (RH) nasal spray containing NaCl. This prospective, controlled, open-label observation study was a multicenter trial. 92 patients with rhinitis sicca we...

  2. Drop impacts on electrospun nanofiber membranes

    Science.gov (United States)

    Sahu, Rakesh P.; Sinha-Ray, Suman; Yarin, Alexander; Pourdeyhimi, Behnam

    2013-11-01

    This work reports a study of drop impacts of polar and non-polar liquids onto electrospun nanofiber membranes (of 8-10 mm thickness and pore sizes of 3-6 nm) with an increasing degree of hydrophobicity. The nanofibers used were electrospun from polyacrylonitrile (PAN), nylon 6/6, polycaprolactone (PCL) and Teflon. It was found that for any liquid/fiber pair there exists a threshold impact velocity (1.5 to 3 m/s) above which water penetrates membranes irrespective of their wettability. The low surface tension liquid left the rear side of sufficiently thin membranes as a millipede-like system of tiny jets protruding through a number of pores. For such a high surface tension liquid as water, jets immediately merged into a single bigger jet, which formed secondary drops due to capillary instability. An especially non-trivial result is that superhydrophobicity of the porous nano-textured Teflon skeleton with the interconnected pores is incapable of preventing water penetration due to drop impact, even at relatively low impact velocities close to 3.46 m/s. A theoretical estimate of the critical membrane thickness sufficient for complete viscous dissipation of the kinetic energy of penetrating liquid corroborates with the experimental data. The current work is supported by the Nonwovens Cooperative Research Center (NCRC).

  3. Drop floating on a granular raft

    Science.gov (United States)

    Jambon-Puillet, Etienne; Josserand, Christophe; Protiere, Suzie

    2015-11-01

    When a droplet comes in contact with a bath of the same liquid, it coalesces to minimize the surface energy. This phenomenon reduces emulsion stability and is usually fought with surfactant molecules. Another way to slow down coalescence is to use colloidal solid particles. In this case the particles spontaneously migrate to the interface to form ``Pickering'' emulsions and act as a barrier between droplets. Here we use dense, large particles (~ 500 μm) which form a monolayer at an oil/water interface that we call a granular raft. When a droplet is placed on top of such a raft, for a given set of particle properties (contact angle/size), the raft prevents coalescence indefinitely. However, in contrast to what happens when a droplet is placed on a hydrophobic surface and never wets the surface, here the droplet is strongly anchored to the raft and deforms it. We will use this specific configuration to probe the mechanical response of the granular raft: by controlling the droplet volume we can impose tensile or compressive stresses. Finally we will show that the drop, spherical at first, slowly takes a more complex shape as it's volume increases. This shape is not reversible as the drop volume is decreased. The drop can become oblate or prolate with wrinkling of the raft.

  4. Ultrafast Drop Movements Arising from Curvature Gradient

    CERN Document Server

    Lv, Cunjing; Chuang, Yin-Chuan; Tseng, Fan-Gang; Yin, Yajun; Zheng, Quanshui

    2011-01-01

    We report experimental observation of a kind of fast spontaneous movements of water drops on surfaces of cones with diameters from 0.1 to 1.5 mm. The observed maximum speed (0.22 m/s) under ambient conditions were at least two orders of magnitude higher than that resulting from any known single spontaneous movement mechanism, for example, Marangoni effect due to gradient of surface tension. We trapped even higher spontaneous movement speeds (up to 125 m/s) in virtual experiments for drops on nanoscale cones by using molecular dynamics simulations. The underlying mechanism is found to be universally effective - drops on any surface either hydrophilic or hydrophobic with varying mean curvature are subject to driving forces toward the gradient direction of the mean curvature. The larger the mean curvature of the surface and the lower the contact angle of the liquid are, the stronger the driving force will be. This discovery can lead to more effective techniques for transporting droplets.

  5. Drop attack during chest radiography: Case report

    International Nuclear Information System (INIS)

    Chest radiography is the first line of thoracic imaging performed in patients with thoracic diseases. It is probably the most frequently performed type of X-ray examination. It is recommended to be performed in the full upright position except where the patient's condition will not permit. This is because the erect technique allows full expansion of the lungs, prevents engorgement of pulmonary vessels and also helps in fluid level evaluation. However, little is reported on the negative effects associated with erect radiography. Herein, we present a case of drop attack during erect chest radiography. - Highlights: • Radiographers should be aware of the possibilities of drop attach during erect chest radiography. • A patient's determination to stand for chest radiograph may not always relate with the ability. • The causes of some drop attacks may be unknown. • Watching patients during radiographic exposure is essential. • Being alert and working very fast during erect chest examinations is important

  6. Bioactivities of some essential oils against the camel nasal botfly, Cephalopina titillator.

    Science.gov (United States)

    Khater, Hanem F

    2014-02-01

    Nasopharyngeal myiasis of camels is caused by the larvae of Cephalopina titillator. We determined the efficacy of essential oils (EOs) of pumpkin, Cucurbita maxima; lupinus, Lupinus luteus; garlic oil, Allium sativum; and peppermint, Mentha piperita, against the third larval stage of C. titillator using larval immersion tests. The positive control group was treated with ivermectin and the negative control one was treated with distilled water and few drops of Tween 80. Larvae were reared until adult emergence. The data indicated that complete larval mortalities were reached 24 h post treatment (PT) with 2 % pumpkin, 7.5 % garlic and peppermint, 30 % lupinus, and 0.15 % ivermectin. The lethal values, LC50s, were 0.20, 0.44, 0.42, 0.47, and 0.03 %, respectively. Pumpkin and ivermectin were 2 and 17 times, respectively, more effective than the other EOs. Ivermectin was seven times more intoxicating than pumpkin oil. Formation of pupae had been stopped after treatment of larvae with 2 % pumpkin, 7.5 % garlic and peppermint, 30 % lupines, and 0.04 % ivermectin. Adult emergence had been completely ceased following treatment of larvae with 0.5 % EOs and 0.04 % ivermectin. Morphological abnormalities were pronounced after treatments, and peppermint oil was the foremost cause of deformation in larvae (44 % PT with 7.5 %) and pupae (40 % PT with 2 %). Pumpkin oil (6 %) was selected to be the drug of choice for controlling C. titillator. Besides their insecticidal effects, EOs are much safer than ivermectin regarding health and environmental issues. Consequently, EOs described herein merit further study as potential nasal drench for C. titillator control. PMID:24276644

  7. Early nasal continuous positive airway pressure in a cohort of the smallest infants in Denmark

    DEFF Research Database (Denmark)

    Hansen, Bo M; Esbjørn, Barbara Hoff; Greisen, G;

    2004-01-01

    To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period.......To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period....

  8. Allergen-induced increase of eosinophil cationic protein in nasal lavage fluid

    DEFF Research Database (Denmark)

    Bisgaard, H; Grønborg, H; Mygind, N;

    1990-01-01

    It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days af...

  9. Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004

    DEFF Research Database (Denmark)

    Thorup, Christian; Sebbesen, Lars; Danø, Hella; Leetmaa, Michael; Andersen, M; von Buchwald, Christian; Kristensen, Claus A; Bentzen, Jens; Godballe, Christian; Johansen, Jørgen; Grau, Cai; Andersen, Maria

    2010-01-01

    To evaluate the treatment outcome for sino-nasal carcinomas in Denmark from 1995-2004 and compare the results to the previous Danish survey covering 1982-1991.......To evaluate the treatment outcome for sino-nasal carcinomas in Denmark from 1995-2004 and compare the results to the previous Danish survey covering 1982-1991....

  10. The Epidemiological and Clinical Aspects of Nasal Polyps that Require Surgery

    Directory of Open Access Journals (Sweden)

    Ahmad Meymane Jahromi

    2011-01-01

    Full Text Available Introduction: The objective of this retrospective cross-sectional study was to obtain epidemiological data from the charts of 297 patients with nasal polyposis who were operated on in a referral hospital in Mashhad and to determine the frequency of the presenting symptoms of nasal polyps.  Materials and Methods: The variables recorded included age, gender, the presence of asthma or allergic rhinitis, family history, and previous treatments. We studied the main symptoms of nasal polyposis (nasal obstruction, rhinorrhea, anosmia, headache, epistaxis, snoring, and so on, as well as ear problems and facial deformity.  Results: Nasal polyposis affects men (60.3% more frequently, at a mean age of 39.5 years. The most frequent symptom was nasal blockage (81.1 % followed by rhinorrhea (37.7%. A total of 11.1% of the patients had a history of epistaxis. Asthma was found in 10.4% of patients with nasal polyposis and the ears were affected in 5.1% of patients. In all, 7.4% of patients had first-degree relatives who suffered from asthma or allergic rhinitis.  Conclusion: This study highlights the need for large-scale epidemiologic research exploring the prevalence and incidence of nasal polyposis in Iran.

  11. Feasibility Investigation of Cellulose Polymers for Mucoadhesive Nasal Drug Delivery Applications.

    Science.gov (United States)

    Hansen, Kellisa; Kim, Gwangseong; Desai, Kashappa-Goud H; Patel, Hiren; Olsen, Karl F; Curtis-Fisk, Jaime; Tocce, Elizabeth; Jordan, Susan; Schwendeman, Steven P

    2015-08-01

    The feasibility of various cellulose polymer derivatives, including methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), sodium-carboxymethylcellulose (sodium-CMC), and cationic-hydroxyethylcellulose (cationic-HEC), for use as an excipient to enhance drug delivery in nasal spray formulations was investigated. Three main parameters for evaluating the polymers in nasal drug delivery applications include rheology, ciliary beat frequency (CBF), and permeation across nasal tissue. Reversible thermally induced viscosity enhancement was observed at near nasal physiological temperature when cellulose derivatives were combined with an additional excipient, poly(vinyl caprolactam)-poly(vinyl acetate)-poly(ethylene glycol) graft copolymer (PVCL-PVA-PEG). Cationic-HEC was shown to enhance acyclovir permeation across the nasal mucosa. None of the tested cellulosic polymers caused any adverse effects on porcine nasal tissues and cells, as assessed by alterations in CBF. Upon an increase in polymer concentration, a reduction in CBF was observed when ciliated cells were immersed in the polymer solution, and this decrease returned to baseline when the polymer was removed. While each cellulose derivative exhibited unique advantages for nasal drug delivery applications, none stood out on their own to improve more than one of the performance characteristics examined. Hence, these data may be useful for the development of new cellulose derivatives in nasal drug formulations. PMID:26097994

  12. Computed tomography of the normal feline nasal cavity and paranasal sinuses

    International Nuclear Information System (INIS)

    Computed tomography (CT) images of the feline nasal cavity and paranasal sinuses were acquired from normal adult cats, Good resolution and anatomic detail were obtained from the CT images using soft tissue formatting. A description of normal feline nasal cavity and paranasal sinus anatomy using CT is presented

  13. Absorption and metabolism of the absorption enhancer didecanoylphosphatidylcholine in rabbit nasal epithelium in vivo

    DEFF Research Database (Denmark)

    Vermehren, C.; Johansen, P.B.; Hansen, Harald S.

    1997-01-01

    The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-H]choline in rabbit nasal mucosa...

  14. Complete Sequence of Enzootic Nasal Tumor Virus, a Retrovirus Associated with Transmissible Intranasal Tumors of Sheep

    OpenAIRE

    Cousens, Christina; Minguijon, Esmeralda; Dalziel, Robert G.; Ortin, Aurora; Garcia, Mercedes; Park, Jane; Gonzalez, Lorenzo; Sharp, J. Michael; De las Heras, Marcelo

    1999-01-01

    The sequence of the complete genome of ovine enzootic nasal tumor virus, an exogenous retrovirus associated exclusively with contagious intranasal tumors of sheep, was determined. The genome is 7,434 nucleotides long and exhibits a genetic organization characteristic of type B and D oncoviruses. Enzootic nasal tumor virus is closely related to the Jaagsiekte sheep retrovirus and to sheep endogenous retroviruses.

  15. Dynamics of Vapor Layer Under a Leidenfrost Drop

    OpenAIRE

    Thomas A. Caswell

    2014-01-01

    In the Leidenfrost effect a small drop of fluid is levitated above a sufficiently hot surface, on a persistent vapor layer generated by evaporation from the drop. The vapor layer thermally insulates the drop from the surface leading to extraordinarily long drop lifetimes. The top-view shape of the levitated drops can exhibit persistent star-like vibrations. I extend recent work [Burton et al. PRL 2012] to study the bottom surface of the drop using interference-imaging. In this work I use a hi...

  16. School Drop out: Patterns, Causes, Changes and Policies

    OpenAIRE

    Sabates, R.; Westbrook, J; Akyeampong, K.; Hunt, F.

    2010-01-01

    This background paper for the UNESCO GMR team draws on a range of resources to provide a synthesis on drop out. The paper focuses on patterns of participation, age-specific drop out rates, equity in drop out rates, and the link between over age enrolment and drop out rates. The paper outlines the main causes of drop out and provides two country case studies, Ghana and Tanzania, to highlight the potential strategies that could be used to address drop out. The paper concludes with our main poli...

  17. Linfoma Extranodal de Células NK/T tipo Nasal Extranodal Nasal type NK/T-Cell Lymphoma

    Directory of Open Access Journals (Sweden)

    Carlos S. Chiattone

    2009-08-01

    Full Text Available O Linfoma Extranodal de Células NK/T tipo Nasal tem uma distribuição geográfica peculiar, ocorrendo mais frequentemente em países orientais e na população nativa de alguns países da América Central e da América do Sul. Sua localização preferencial é na cavidade nasal e nos seios paranasais, mas pode acometer outras estruturas da chamada região médio-facial. Tem um padrão de disseminação com "homing" característico, incluindo pele, testículo, SNC e trato digestivo. Este linfoma, menos frequentemente, pode acometer primariamente estas regiões. A maioria destas neoplasias apresenta um fenótipo NK, mas alguns poucos casos podem ter sua origem em células T verdadeiras, por este motivo é designado "linfoma NK/T". O genoma do vírus Epstein-Barr é detectado na maioria dos casos, sugerindo uma relação etiológica. Embora este linfoma seja sensível à radioterapia, apresenta mais frequentemente resistência a agentes quimioterápicos que outros linfomas. Uma possível explicação para a resistência é a usual expressão de glicoproteína-p. O prognóstico destes linfomas é pobre, sendo necessária a investigação de novas modalidades terapêuticas.Extranodal Nasal type NK/T-Cell Lymphoma has a peculiar geographic distribution, occurring more frequently in Eastern countries and in the native populations of some Central and South American countries. It is commonly found in the nasal cavity and paranasal sinuses, but may also compromise other structures in the mid-facial region. The disease has a characteristic homing dissemination pattern, including skin, testis, CNS and digestive tract. This lymphoma can, less frequently, primarily compromise these regions. The majority of these neoplastic diseases present an NK phenotype, but a few cases can be truly of T-cell origin, because of which it is designed "NK/T-cell lymphoma". The Epstein-Barr virus genome can be detected in most of the cases, suggesting an etiological

  18. Westernization of the Asian Nose by Augmentation of the Retropositioned Anterior Nasal Spine With an Injectable Filler

    OpenAIRE

    Tanaka, Yohei; Matsuo, Kiyoshi; Yuzuriha, Shunsuke

    2011-01-01

    Objective: The aging nose presents as a drooping nasal tip secondary to atrophy of the underlying bony support with a relatively prominent dorsal hump. We hypothesized that low nasal tip projection in the Asian nose may be secondary to the retropositioned anterior nasal spine (ANS) as well. Therefore, we investigated how filler injection between the medial crura and the retropositioned ANS affects the nasal shape. Methods: Local anesthetic was injected on the ANS for analgesia and simulation ...

  19. Angular vessels as a new vascular pedicle of an island nasal chondromucosal flap: Anatomical study and clinical application

    OpenAIRE

    HOU, DIANJU; Fang, Lin; Zhao, Zhenmin; ZHOU, CHUANDE; YANG, MINGYONG

    2012-01-01

    Successful eyelid reconstructions have been reported when using an axial nasal chondromucosal flap based on the dorsal nasal artery. The present study aimed to present a detailed anatomical description of the blood supply of the lateral nasal region and the angular artery, in order to propose the angular vessels as a new vascular pedicle for the island nasal chondromucosal flap. A total of 11 cadavers (22 hemi-faces) were examined. Observations with regard to the origin, course and distributi...

  20. Laplacian drop shapes and effect of random perturbations on accuracy of surface tension measurement for different drop constellations.

    Science.gov (United States)

    Saad, Sameh M I; Neumann, A Wilhelm

    2015-08-01

    Theoretical drop shapes are calculated for three drop constellations: pendant drops, constrained sessile drops, and unconstrained sessile drops. Based on total Gaussian curvature, shape parameter and critical shape parameter are discussed as a function of different drop sizes and surface tensions. The shape parameter is linked to physical parameters for every drop constellation. The as yet unavailable detailed dimensional analysis for the unconstrained sessile drop is presented. Results show that the unconstrained sessile drop shape depends on a dimensionless volume term and the contact angle. Random perturbations are introduced and the accuracy of surface tension measurement is assessed for precise and perturbed profiles of the three drop constellations. It is concluded that pendant drops are the best method for accurate surface tension measurement, followed by constrained sessile drops. The unconstrained sessile drops come last because they tend to be more spherical at low and moderate contact angles. Of course, unconstrained sessile drops are the only option if contact angles are to be measured. PMID:25466689