WorldWideScience

Sample records for baculovirus-based nasal drop

  1. Appl ication of compound mint nasal drops for patients receiving sputum suction via nasal cavity Application of compound mint nasal drops for patients with sputum suction via nasal cavity%复方薄荷滴鼻液在经鼻吸痰病人中的应用

    Institute of Scientific and Technical Information of China (English)

    葛宝兰; 马莉

    2015-01-01

    Objective:To relieve the nasal mucosa bleeding and burst in patients caused by sputum suction via na-sal cavity.Methods:A total of 90 cases of elderly patients who need sputum suction via nasal cavity were divided into two groups,they separately used the compound mint nasal drops for lubrication and physiological saline for lubrication.The nasal mucosa bleeding and nasal mucosa burst of patients were observed in both groups.Re-sults:The compound mint nasal drops lubrication method can reduce the nasal cavity bleeding and nasal mucosa damage.Conclusion:The application of compound mint nasal drops used in lubrication of nasal cavity can effec-tively reduce the nasal mucosa bleeding and damage,improve the quality of sputum suction and the patient’s comfort level when Sputun suction via nasal cavity.%[目的]减轻病人因经鼻吸痰时而引起的鼻腔黏膜出血及破溃。[方法]将本科室需经鼻腔吸痰的90例老年病人分为两组,分别采用复方薄荷滴鼻液润滑鼻腔和生理盐水润滑鼻腔。观察两组病人鼻腔黏膜出血情况及鼻腔黏膜破溃情况。[结果]复方薄荷滴鼻液润滑鼻腔法可减少鼻腔出血及鼻黏膜受损。[结论]在经鼻吸痰时应用复方薄荷滴鼻液润滑鼻腔可以有效减少鼻腔黏膜出血及损伤,提高吸痰质量和病人的舒适程度。

  2. Nasal temperature drop in response to a playback of conspecific fights in chimpanzees: A thermo-imaging study.

    Science.gov (United States)

    Kano, Fumihiro; Hirata, Satoshi; Deschner, Tobias; Behringer, Verena; Call, Josep

    2016-03-01

    Emotion is one of the central topics in animal studies and is likely to attract attention substantially in the coming years. Recent studies have developed a thermo-imaging technique to measure the facial skin temperature in the studies of emotion in humans and macaques. Here we established the procedures and techniques needed to apply the same technique to great apes. We conducted two experiments respectively in the two established research facilities in Germany and Japan. Total twelve chimpanzees were tested in three conditions in which they were presented respectively with the playback sounds (Exp. 1) or the videos (Exp. 2) of fighting conspecifics, control sounds/videos (allospecific display call: Exp. 1; resting conspecifics: Exp. 2), and no sound/image. Behavioral, hormonal (salivary cortisol) and heart-rate responses were simultaneously recorded. The nasal temperature of chimpanzees linearly dropped up to 1.5 °C in 2 min, and recovered to the baseline in 2 min, in the experimental but not control conditions. We found the related changes in excitement behavior and heart-rate variability, but not in salivary cortisol, indicating that overall responses were involved with the activities of sympathetic nervous system but not with the measureable activities of the hypothalamus-pituitary-adrenal (HPA) axis. The influence of general activity (walking, eating) was not negligible but controllable in experiments. We propose several techniques to control those confounding factors. Overall, thermo-imaging is a promising technique that should be added to the traditional physiological and behavioral measures in primatology and comparative psychology. PMID:26657470

  3. Not Just a Drop in the Bucket-Inversion of Oxymetazoline Nasal Decongestant Container Increases Potential for Severe Pediatric Poisoning.

    Science.gov (United States)

    Nordt, Sean Patrick; Vivero, Lisa E; Cantrell, F Lee

    2016-01-01

    Oxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model.

  4. EFFICACY OF TOPICAL APPLICATION OF EPHEDRINE AND FURACILIN NASAL DROPS COMBINED WITH TETRACAINE IN REDUCING COMPLICATIONS OF POSTOPERATIVE NASAL PACK REMOVAL%局部应用呋麻滴鼻液及丁卡因减少鼻腔填塞物拔除时并发症的临床分析

    Institute of Scientific and Technical Information of China (English)

    王振英; 蔡邦; 陈国锋

    2015-01-01

    Objective To assess the efficacy of topical application of Ephedrine and furacilin nasal drops combined with tetracaine in reducing complications of pack removal after nasal surgery.Methods 81caseshaving un-dergone nasal septum surgery were randomly divided into the experimental group and control group: the former were treated with Ephedrine and furacilin nasal drops combined with tetracaine and the blank control group.The occur-rence of complications at removing nasal fillers after nasal surgery was assessed.Results The hemorrhage and pain in the experimental group were significantly less than those in the blank control group (p <0.05).Conclusion top-ical application of Ephedrine and furacilin nasal drops combined with tetracaineis an effective method for reducing the pains of pack removal after nasal surgery.%目的:探索减少鼻腔填塞物拔除时并发症的方法。方法81例鼻中隔手术后患者采用随机对照的方法,通过鼻腔填塞物局部应用呋麻滴鼻液及丁卡因或空白对照,评估鼻腔填塞物拔除时的并发症发生情况。结果鼻腔填塞物局部用药组在出血及疼痛方面优于空白对照组。结论通过呋麻滴鼻液及丁卡因的局部混合应用,达到明显减少患者鼻腔填塞物拔除的痛苦的效果。

  5. Effects of Xanthium sibiricum nasal drops on allergic rhinitis in guinea pigs%复方苍耳子滴鼻剂对豚鼠变应性鼻炎的影响

    Institute of Scientific and Technical Information of China (English)

    李道佩; 戴卫波; 吴又明

    2012-01-01

    Objective To determine the effects of compound Xanthii sibiricum nasal drops on changes in symptoms and serum histamine level in allergic rhinitis guinea pig models. Methods The guinea pig nasal mucosal allergy model was established by using toluene-2,4-diisocyanate (2, 4-TDI) as a sensitizer. The level of histamine and morphohistological changes of each group were determined, with model group, positive drug group and blank control group regarded as controls. Results For nasal symptoms, both high and low dosage of compound Xanthii sibiricum nasal drops were associated with significant improvement in post-treatment total score when compared with pre- treatment levels (both P<0.05), suggesting marked recovery of overall symptoms in chronic rhinitis animal models. Both high and low dosage of compound Xanthii sibiricum nasal drops have, in terms of the impact on serum histamine lev -el, resulted in considerably lower figures than model group (P<0.05 or 0.01), indicating significant attenuation of serum histamine in chronic rhinitis animal model. Additionally, both high and low dosage of compound Xanthii sibiricum nasal drops have led to morphohistological improvements with regard to epithelial metaplasia, hyperplasia of glands, vascular hyperplasia or dilatation as well as inflammatory cell counts in nasal mucosa. Conclusion Experimental allergic rhinitis in rats may benefit considerably from compound Xanthii sibiricum nasal drops treatment.%目的 观察复方苍耳子滴鼻剂对变应性鼻炎模型豚鼠症状的变化和血清组胺含量的影响.方法 以甲苯-2,4-二异氰酸甲苯酯(TDI)作为致敏因子建立豚鼠鼻黏膜变态反应模型,以模型组、阳性药物组与空白组为对照,测定各组豚鼠鼻黏膜内组胺的含量及形态组织学的改变.结果 ①鼻部症状的改善情况:复方苍耳子滴鼻剂高、低剂量组药前总评分与药后总评分比较差异有统计学意义(P<0.05),能显著性改善慢性鼻炎模型动

  6. 均匀设计优化复方黄芩苷滴鼻凝胶基质处方%OPtimization of matrix formulation for ComPound Baicalin Gel Nasal DroPs By uniform design

    Institute of Scientific and Technical Information of China (English)

    孙迎东; 胡丽敏; 刘明华; 王玉; 汪风芹

    2015-01-01

    OBjective TooptimizethematrixformulationofDompoundBaicalinGelNasalDropsbyuniformde-sign.Methods Thematrixformulationwasoptimizedbyathreefactorandtenleveluniformdesign,withrheologicalpa-rameterssuchaspHvalue,viscosity,fluidity,appearanceandparticlesize.Results Theoptimummatrixformulationwas established as follows:0. 5 g carbomer-940,0. 75 g borax,10 mL phosphate buffer( pH 6. 0)in 100 g Dompound Baicalin Gel Nasal Drops. The Dompound Baicalin Gel Nasal Drops was pale yellow,transparent and colloidal liquid. The pH value was6.0.Theviscositywas2500~2800mPa·s.Conclusion TheDompoundBaicalinGelNasalDropspreparedbythe method had characteristics such as good drug stability and good applicability.%目的:利用均匀设计法优化复方黄芩苷滴鼻凝胶基质处方。方法采用3因素10水平均匀设计方案,以复方黄芩苷滴鼻凝胶的pH值、黏度及可滴性、外观性状及粒度为评价指标,对基质处方进行优化。结果优化基质处方组成为:每100 g复方黄芩苷滴鼻凝胶含卡波姆-9400.5 g,硼砂0.75 g、磷酸盐缓冲液( pH 6.0)10 mL。按优化处方制备的复方黄芩苷滴鼻凝胶为浅黄色透明的胶状液体,pH 6.0,黏度为2500~2800 mPa·s。结论按优化处方制备的复方黄芩苷滴鼻凝胶为淡黄色透明胶液、色泽均匀、性质稳定,使用方便。

  7. Nasal Physiology

    Science.gov (United States)

    ... Q&A Complications of Sinusitis Epistaxis (Nosebleeds) Allergic Rhinitis (Hay Fever) Headaches and Sinus Disease Disorders of ... of the autonomic, i.e. automatic, nervous system) controls blood flow to the nasal cavity and nasal ...

  8. Nasal Cancer

    Science.gov (United States)

    ... the way to your throat as you breathe. Cancer of the nasal cavity and paranasal sinuses is ... be like those of infections. Doctors diagnose nasal cancer with imaging tests, lighted tube-like instruments that ...

  9. Oxymetazoline Nasal Spray

    Science.gov (United States)

    Afrin® Nasal Spray ... Anefrin® Nasal Spray ... Dristan® Nasal Spray ... Mucinex® Nasal Spray ... Nostrilla® Nasal Spray ... Vicks Sinex® Nasal Spray ... Zicam® Nasal Spray ... Oxymetazoline nasal spray is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to ...

  10. Nasal encephaloceles

    NARCIS (Netherlands)

    Hoving, Eelco W.

    2000-01-01

    Nasal encephaloceles can be divided into frontoethmoidal and basal encephaloceles. Both conditions are very rare, but frontoethmoidal encephaloceles show a relatively high incidence (1:5,000) in Southeast Asia. The pathogenesis of encephaloceles may be explained by a disturbance in separation of sur

  11. Nasal Wash Treatment

    Science.gov (United States)

    ... Disease Medications > Alternative Therapies > Nasal Wash Treatment Nasal Wash Treatment The Centers for Disease Control (CDC) guidelines ... increases airflow Watch How to Perform a Nasal Wash CDC Water Preparation Guidelines Wash your hands. Make ...

  12. Nicotine Nasal Spray

    Science.gov (United States)

    Nicotine nasal spray is used to help people stop smoking. Nicotine nasal spray should be used together with a smoking cessation ... counseling, or specific behavior change techniques. Nicotine nasal spray is in a class of medications called smoking ...

  13. Foot Drop

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Foot Drop Information Page Table of Contents (click to ... research is being done? Clinical Trials What is Foot Drop? Foot drop describes the inability to raise ...

  14. Nasal chondromesenchymal hamartoma with no nasal symptoms.

    LENUS (Irish Health Repository)

    Uzomefuna, Vincent

    2012-01-01

    The authors present a case of nasal chondromesenchymal hamartoma (NCMH) in an 8-year-old boy with a 4-month history of frontal headache and no symptoms of nasal obstruction, rhinorrhoea or postnasal drip. An ENT examination as well as ophthalmology assessment presented normal results. CT scan showed a lesion involving the sphenoid and ethmoid sinuses. The patient had an endoscopic resection of the lesion that was confirmed histologically to be a NCMH. Though NCMH is known to present usually in infants with obstructing nasal mass, an unusual presentation of a patient with throbbing headache without any nasal symptoms is reported here.

  15. Bacterial Nasal Infections

    Science.gov (United States)

    ... the Nose Sinusitis Bacteria may cause pimples and boils (furuncles) to form just inside the opening of ... weeks. Nasal furuncles More serious infections result in boils (furuncles) in the nasal vestibule. Boils may develop ...

  16. Nasal mucosal biopsy

    Science.gov (United States)

    Biopsy - nasal mucosa; Nose biopsy ... to fast for a few hours before the biopsy. ... Nasal mucosal biopsy is usually done when abnormal tissue is seen during examination of the nose. It may also be done ...

  17. Mometasone Nasal Spray

    Science.gov (United States)

    Mometasone nasal spray is used to prevent and relieve symptoms of sneezing, runny, stuffy, or itchy nose caused by hay fever ... of the lining of the nose). Mometasone nasal spray should not be used to treat symptoms (e. ...

  18. Flunisolide Nasal Spray

    Science.gov (United States)

    Flunisolide nasal spray is used to relieve symptoms of sneezing, runny, stuffy, or itchy nose caused by hay fever or other allergies. Flunisolide nasal spray should not be used to treat symptoms (e. ...

  19. Naloxone Nasal Spray

    Science.gov (United States)

    Naloxone nasal spray is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. Naloxone nasal spray is in a class of medications called opiate ...

  20. Soft Drop

    CERN Document Server

    Larkoski, Andrew J; Soyez, Gregory; Thaler, Jesse

    2014-01-01

    We introduce a new jet substructure technique called "soft drop declustering", which recursively removes soft wide-angle radiation from a jet. The soft drop algorithm depends on two parameters--a soft threshold $z_\\text{cut}$ and an angular exponent $\\beta$--with the $\\beta = 0$ limit corresponding roughly to the (modified) mass drop procedure. To gain an analytic understanding of soft drop and highlight the $\\beta$ dependence, we perform resummed calculations for three observables on soft-dropped jets: the energy correlation functions, the groomed jet radius, and the energy loss due to soft drop. The $\\beta = 0$ limit of the energy loss is particularly interesting, since it is not only "Sudakov safe" but also largely insensitive to the value of the strong coupling constant. While our calculations are strictly accurate only to modified leading-logarithmic order, we also include a discussion of higher-order effects such as multiple emissions and (the absence of) non-global logarithms. We compare our analytic r...

  1. Calcitonin Salmon Nasal Spray

    Science.gov (United States)

    ... pump is now primed. To use the nasal spray, follow these steps: Keep your head up and place the nozzle in one nostril. Press down on the pump ... reach of children. Store unopened calcitonin salmon nasal spray in the ... the nozzle clean. Opened calcitonin salmon stored at room temperature ...

  2. Olopatadine Nasal Spray

    Science.gov (United States)

    Olopatadine nasal spray is used to relieve sneezing and a stuffy, runny or itchy nose caused by allergic rhinitis (hay fever). ... Olopatadine comes as a liquid to spray in the nose. Olopatadine nasal spray ... twice daily. Follow the directions on your prescription label carefully, ...

  3. Ketorolac Nasal Spray

    Science.gov (United States)

    Ketorolac nasal spray is used for the short-term relief of moderate to moderately severe pain. Ketorolac is in a class ... Nasal ketorolac comes as a liquid to spray in the nose. It is usually used once every 6 to 8 hours as needed to control pain for up to 5 days. ...

  4. Nasal mucociliary transport in laryngectomees

    Energy Technology Data Exchange (ETDEWEB)

    Pavia, J.; Garcia, A.; Abello, R.; Herranz, R.; Franch, M.; Espana, R. de

    1986-04-01

    A study has been carried out to assess the mucociliary function of nasal mucosa in 30 patients: 16 had undergone surgery due to larynx malignancy and the remaining 14 were divided in two groups. The first group was composed of seven patients suffering from larynx cancer but not operated, and the second group of seven had pathology not related to the airways (control group). The method used a sup(99m)technetium sulphur colloid drop deposited on the nasal mucosa of one nostril. To calculate the rate of transport, a new method of quantification has been introduced, based on the formation of a parametric image. The mean velocity in laryngectomees was 3.6 mm/min (range 1.1-6.4). It was compared with the group of 14 patients without tracheostomy (mean 5.3, range 3.3-8.2). An impaired student's-t-test gave a significant difference between both groups. The comparison between patients with nonoperated larynx cancer and normals have a nonsignificant difference. The 16 operated patients were arbitrarily divided into two groups as per the time elapsed from laryngectomy; seven were studied within the first 3 years of operation and seven other patients after this term. The comparison between them was not significant.

  5. Budesonide Nasal Spray

    Science.gov (United States)

    ... ingredients in budesonide nasal spray. Check the package label for a list of the ingredients.tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or ...

  6. Fluticasone Nasal Spray

    Science.gov (United States)

    ... ingredients in fluticasone nasal spray. Check the package label for a list of the ingredients.tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking, or ...

  7. Zolmitriptan Nasal Spray

    Science.gov (United States)

    ... a copy of the manufacturer's information for the patient.To use the nasal spray, follow these steps: ... used to treat certain types of migraine headaches (hemiplegic or basilar) or other types of headaches (such ...

  8. Fentanyl Nasal Spray

    Science.gov (United States)

    Fentanyl nasal spray is used to treat breakthrough pain (sudden episodes of pain that occur despite round ... effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called narcotic ( ...

  9. Nasal packing and stenting

    Directory of Open Access Journals (Sweden)

    Weber, Rainer K.

    2009-01-01

    Full Text Available Nasal packs are indispensable in ENT practice. This study reviews current indications, effectiveness and risks of nasal packs and stents. In endoscopic surgery, nasal packs should always have smooth surfaces to minimize mucosal damage, improve wound healing and increase patient comfort. Functional endoscopic endonasal sinus surgery allows the use of modern nasal packs, since pressure is no longer required. So called hemostatic/resorbable materials are a first step in this direction. However, they may lead to adhesions and foreign body reactions in mucosal membranes. Simple occlusion is an effective method for creating a moist milieu for improved wound healing and avoiding dryness. Stenting of the frontal sinus is recommended if surgery fails to produce a wide, physiologically shaped drainage path that is sufficiently covered by intact tissue.

  10. Beclomethasone Nasal Spray

    Science.gov (United States)

    ... symptoms may begin to improve a few days after you first use beclomethasone, but it may take 1 ... your symptoms get worse or do not improve after you use beclomethasone nasal spray for 3 weeks. If ...

  11. FRACTURE NASAL BONES

    OpenAIRE

    Balasubramanian Thaigarajan; Venkatesan Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography a...

  12. Fracture Nasal Bone

    OpenAIRE

    Balasubramanian, Thiagarajan; Venkatesan, Ulaganathan

    2013-01-01

    Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and u...

  13. Dropped Ceiling

    OpenAIRE

    Tabet, Rayyane

    2012-01-01

    On December 2nd 1950 the first drop of Saudi oil arrived to Lebanon via the newly constructed Trans-Arabian Pipeline, the world's longest pipeline and the largest American private investment in a foreign land. The 30inch wide structure which spanned 1213 kilometers passing through Saudi Arabia, Jordan, and Syria to end in Lebanon had required 3 years of planning and surveying, 2 years of installation, the fabrication of 256,000 tons of steel tubes, the employment of 30,000 workers, the ratifi...

  14. Nasal septum extramedullary plasmacytoma

    Directory of Open Access Journals (Sweden)

    Belić Branislav

    2013-01-01

    Full Text Available Introduction. Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate in either bone - solitary osseous plasmacytoma, or in soft tissue - extramedullary plasmacytoma (EMP. EMP represents less than 1% of all head and neck malignancies. Case report. We presented a case of EMP of the nasal septum in a 44-year-old male who had progressive difficulty in breathing through the nose and frequent heavy epistaxis on the right side. Nasal endoscopy showed dark red, soft, polypoid tumor in the last third of the right nasal cavity arising from the nasal septum. The biopsy showed that it was plasmacytoma. Bence Jones protein in the urine, serum electrophoresis, bone marrow biopsy, skeletal survey and other screening tests failed to detect multiple myeloma. This confirmed the diagnosis of EMP. The mass was completely removed via an endoscopic approach, and then, 4 week later, radiotherapy was conducted with a radiation dose of 50 Gray. No recurrence was noted in a 3-year follow- up period. Conclusion. EMP of the nasal cavity, being rare and having long natural history, represents a diagnostic and therapeutic challenge for any ear, nose and throat surgeon. Depending on the resectability of the lesion, a combined therapy is the accepted treatment.

  15. Nasal palatal: segment complex

    Directory of Open Access Journals (Sweden)

    Lourdes Romera

    2015-10-01

    Full Text Available This paper focuses on the nature of a segment which is always problematical —the palatal nasal. Phonetic results found in the acoustic, perceptive and articulate spheres, showing the different features of this nasal with regards to others, are the point of departure for a brief reflection on the phonological nature of this segment, taking into account the feature geometry and the articulatory phonology. It concludes by considering the palatal nasal /?/ as a complex segment formed by /n+j/ and the imputation, to temporary effects, of a degree of major o minor assimilation and gestural overlapping during effective perception of /?/, of /n+j/ or of /n+i/.

  16. OUTCOMES FOLLOWING NASAL SURGERY WITH AND WITHOUT POSTOPERATIVE NASAL DRESSINGS

    Directory of Open Access Journals (Sweden)

    Surya Prakasa Rao

    2015-02-01

    Full Text Available PURPOSE OF STUDY: Nasal dressing following nasal surgery in an attempt to prevent postoperative bleeding and to modulate the wound healing process. Experience with postoperative nasal dressings in otolaryngologic literature spans more than half a century; despite of this, there is still little agreement between the surgeons on the appropriate choice of nasal dressings following nasal surgery , or whether nasal dressings are required at all. This paper briefly reviews the comparative study between the postoperative case s wi th and without nasal dressings. STUDY DESIGN: It is a prospective study carried out in a te rtiary care, teaching hospital. MATERIALS AND METHODS: A prospective evaluation of patients who underwent nasal surgery at tertiary teaching hospital setting bet ween February 2013 to June 2014 was performed. Nasal dressing was done in some cases who underwent nasal surgery and no dressing was done in some cases. The comparative results between the cases with and without nasal packing in terms of Postoperative blee ding, Adhesion formation, Middle turbinate lateralization were studied. RESULTS: Out of 160 patients included in this study, nasal dressing postoperatively was done in 92 cases and 68 cases were not packed postoperatively. In terms of postoperative bleedin g there is no significant difference between the cases with packs (5.43% and without pack (5.88%. Postoperative Adhesion formation was less in cases without nasal packing ( 2.94% than in cases with nasal dressing ( 8.7%. Middle turbinate lateralization i s also less in cases without nasal packing ( 8.82% than in cases with nasal packing (17.5%. CONCLUSION: The decision as to whether to pack the nose after nasal surgery remains controversial. There has been an increasing tendency to move away from removabl e nasal dressings due to discomfort and bleeding upon removal and also postoperative adhesions. This study showcases that there is no considerable difference in

  17. Dihydroergotamine Injection and Nasal Spray

    Science.gov (United States)

    Migranal® Nasal Spray ... inject subcutaneously (under the skin) and as a spray to be used in the nose. It is ... that you know how to use the nasal spray or administer the injection correctly. After that, you ...

  18. FRACTURE NASAL BONES

    Directory of Open Access Journals (Sweden)

    Balasubramanian Thaigarajan

    2013-03-01

    Full Text Available Nose is the most prominent part of the face, hence it is likely to be the most common structure to be injured in the face. Although fractures involving the nasal bones are very common, it is often ignored by the patient. Patients with fractures of nasal bone will have deformity, tenderness, haemorrhage, edema, ecchymosis, instability, and crepitation. These features may be present in varying combinations. This article discusses the pathophysiology of these fractures, role of radiography and ultrasound in their diagnosis and their management.

  19. Nasalance Norms in Greek Adults

    Science.gov (United States)

    Okalidou, Areti; Karathanasi, Asimina; Grigoraki, Eleni

    2011-01-01

    The purposes of this study were to derive nasalance norms for monolingual Greek speakers, to examine nasalance scores as a function of gender and to draw cross-linguistic comparisons based on normative data. Participants read aloud a corpus of linguistic material, consisting of (1) a nasal text, an oral text and a balanced text; (2) a set of nasal…

  20. Cosmetic and Functional Nasal Deformities

    Science.gov (United States)

    ... nasal complaints. Nasal deformity can be categorized as “cosmetic” or “functional.” Cosmetic deformity of the nose results in a less ... taste , nose bleeds and/or recurrent sinusitis . A cosmetic or functional nasal deformity may occur secondary to ...

  1. Butorphanol Nasal Spray

    Science.gov (United States)

    ... have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/cder) to obtain the Medication Guide. ... butorphanol, any other medications, or benzethonium chloride (a preservative ... nasal spray. Alcohol can make the side effects of the medication worse.

  2. Ciclesonide Nasal Spray

    Science.gov (United States)

    Ciclesonide nasal spray is used to treat the symptoms of seasonal (occurs only at certain times of the year), and perennial ( ... Ciclesonide comes as a solution (liquid) to spray in the nose. It is usually sprayed in each nostril once daily. Use ciclesonide at around the same time every day. Follow the ...

  3. Assessment of nasal obstruction with flexible nasal endoscopy

    International Nuclear Information System (INIS)

    Objective was to report the value of nasal endoscopy as an outpatient procedure in the diagnosis of posterior nasal obstruction. Over one year period, from March 2002 to March 2003, we evaluated 130 adult patients that attended the Ear, Nose and Throat Department of Sohag University Hospital in Egypt with persistent nasal obstruction via anterior rhinoscopy and flexible nasopharyngoscopy. We reported the cause and site of obstruction in relation to the choanae. We confirmed the diagnosis by CT scanning, rigid endoscopic examination under general anesthesia, and histopathological analysis of biopsies taken. Forty-six percent of our cases had posterior nasal obstruction, 43.5% due to post-choanal lesions (mainly adenoid), 33% due to pre-choanal lesions (mainly choanal polyps), and 23.5% due to choanal lesions (mainly choanal adenoid). We conclude that flexible nasal endoscopy is superior to visual examination in the evaluation of nasal obstruction; hence, we recommend its routine use. (author)

  4. Congenital nasal lipoma

    International Nuclear Information System (INIS)

    The authors describe a rare case of congenital lipoma of a nose and nasopharynx in a 7 months old girl. The tumor, about 7 x 2 cm was situated in the right nasal cavity and the nasopharynx. The tumor caused complete obstruction of the right side of the nose. After CT diagnosis the tumor was excised from intranasal approach. Histological examination disclosed lipoma. The duration of follow up was 10 months without any sight of recurrence. (author)

  5. Health risks associated with inhaled nasal toxicants

    NARCIS (Netherlands)

    Feron, V.J.; Arts, J.H.E.; Kuper, C.F.; Slootweg, P.J.; Woutersen, R.A.

    2001-01-01

    Health risks of inhaled nasal toxicants were reviewed with emphasis on chemically induced nasal lesions in humans, sensory irritation, olfactory and trigeminal nerve toxicity, nasal immunopathology and carcinogenesis, nasal responses to chemical mixtures, in vitro models, and nasal dosimetry- and me

  6. Numerical investigation of the flow field in realistic nasal septal perforation geometry.

    Science.gov (United States)

    Faramarzi, Mohammad; Baradaranfar, Mohammad Hossein; Abouali, Omid; Atighechi, Saeid; Ahmadi, Goodarz; Farhadi, Pejman; Keshavarzian, Erfan; Behniafard, Nasim; Baradaranfar, Amin

    2014-07-01

    The computational fluid dynamics (CFD) are used to evaluate the physiological function of the nose. We evaluated the aerodynamics of the nasal cavity in a patient with septal perforation (SP), pre- and postvirtual repair. Three-dimensional nasal models were reconstructed, and then a wide range of the pressure drops and flow rates were analyzed. The airflow velocity is higher in the central region and is lower around the boundary of the SP. The air velocity in the SP increases as the pressure drop increases. Furthermore, at the anterior part of the SP, the shear stress is higher in the upper part. In addition, the repair of SP does not affect the total nasal airflow rate and the velocity contour patterns. The potential usage of the CFD technique as a predictive technique to explore the details and a preoperative assessment tool to help in clinical decision making in nasal surgery is emphasized. PMID:24988523

  7. Nasendoscopy for unusual nasal symptoms

    OpenAIRE

    Vedasalam, S; Sipaul, F.; Hill, A.; Porter, G.

    2010-01-01

    A 20-year-old woman who was fit and well presented with a history of left nasal blockage for 2 years. She was noted on anterior rhinoscopy to have nasal septal deviation towards the left. She was listed for septoplasty with the aim of relieving nasal obstruction. At operation she was found to have a mildly deviated septum to the left. There was also a rhinolith in the left nostril posterior to the deviated septum (figure 1). Following removal of the rhinolith, her nasal airway appeared adequa...

  8. Dilating Eye Drops

    Science.gov (United States)

    ... Frequently Asked Questions Español Condiciones Chinese Conditions Dilating Eye Drops En Español Read in Chinese What are dilating eye drops? Dilating eye drops contain medication to enlarge ( ...

  9. COMPARATIVE THERAPEUTIC EFFECTS OF VARIOUS MORPHOLOGICAL FORMS OF NASYA (NASAL ROUTE OF DRUG DELIVERY IN PRATISHYAYA (RHINOSINUSITIS WITH REFERENCE TO NASAL MUCO-CILIARY FUNCTION

    Directory of Open Access Journals (Sweden)

    Bhardwaj Atul

    2012-10-01

    Full Text Available Different morphological forms of Nasyas (Nasal route of drug administration in Ayurveda like Taila and Ghrita (lipid based nasal drops, churna (dry fine powder and Avpeeda nasya (Aqueous based medicated decoction nasal drops are commonly used as nasal drugs for the management of rhinological disorders in Ayurveda and they distinctly behave differently in the nasal cavity when introduced. This present study explores how these different morphological forms of Nasyas effects the nasal health and mucociliary mechanism in the patients of Pratishyaya i.e. Rhinosinusitis with the help of Goldman’s saccharin test which is carried out at various stages of this study. Clinically, endoscopically and radiologically diagnosed patients of Pratishyaya i.e. rhinosinusitis, satisfying the inclusion criteria were divided randomly by table method into four groups. A total of 40 patients were subjected in this trial after ramification into four trial groups with 10 patients in each group. Anu taila nasya, Shadbindu ghrita nasya, Katphala churna nasya and Pippali Avapeeda nasya respectively were selected for the present study in trial groups I – IV as they are the most frequently prescribed drugs in Ayurveda (Indian system of medicine for the management of the disease Pratishyaya i.e. Rhinosinusitis. These selected drugs subtly represent medicated oils/lipids, powder insufflations (errhines and medicated aqueous base decoction form of nasal drug administration when visualized in morphological appearance and modern perspective. Goldman’s saccharin test, which is used for the present study is a gold standard test for the evaluation of nasal mucociliary function and is directly related to nasal health. Powder form of nasal administered drug i.e. Katphala Churna nasya (powder form was found to be most effective in improvement of endoscopic and radiological parameters of rhinosinusitis. Mucoadhesive properties of Anu Taila nasya and Shadbindu ghrita nasya (both

  10. Definitive magnetic nasal prosthesis for partial nasal defect

    Directory of Open Access Journals (Sweden)

    E Nagaraj

    2011-01-01

    Full Text Available Maxillofacial trauma refers to any injury to the face or jaw caused by physical force, trauma, the presence of foreign objects, animal or human bites, and burns. Facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potential compromises in quality of life. Restoration of facial defects, especially nasal defects, is a difficult challenge for both the surgeon and the prosthodontist. Here is a case report of partial nasal defect caused by trauma, rehabilitated with a magnetic nasal prosthesis made with silicone elastomers using mechanical and anatomical retentive aids.

  11. Pathogenesis of nasal polyposis.

    Science.gov (United States)

    Hulse, K E; Stevens, W W; Tan, B K; Schleimer, R P

    2015-02-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition that affects a large proportion of the population world-wide and is associated with high cost of management and significant morbidity. Yet, there is a lack of population-based epidemiologic studies using current definitions of CRSwNP, and the mechanisms that drive pathogenesis in this disease remain unclear. In this review, we summarize the current evidence for the plethora of factors that likely contribute to CRSwNP pathogenesis. Defects in the innate function of the airway epithelial barrier, including diminished expression of antimicrobial products and loss of barrier integrity, combined with colonization by fungi and bacteria likely play a critical role in the development of chronic inflammation in CRSwNP. This chronic inflammation is characterized by elevated expression of many key inflammatory cytokines and chemokines, including IL-5, thymic stromal lymphopoietin and CCL11, that help to initiate and perpetuate this chronic inflammatory response. Together, these factors likely combine to drive the influx of a variety of immune cells, including eosinophils, mast cells, group 2 innate lymphoid cells and lymphocytes, which participate in the chronic inflammatory response within the nasal polyps. Importantly, however, future studies are needed to demonstrate the necessity and sufficiency of these potential drivers of disease in CRSwNP. In addition to the development of new tools and models to aid mechanistic studies, the field of CRSwNP research also needs the type of robust epidemiologic data that has served the asthma community so well. Given the high prevalence, costs and morbidity, there is a great need for continued research into CRS that could facilitate the development of novel therapeutic strategies to improve treatment for patients who suffer from this disease. PMID:25482020

  12. Keratoacanthoma: an unusual nasal mass.

    Science.gov (United States)

    Sazafi, M S; Salina, H; Asma, A; Masir, N; Primuharsa Putra, S H A

    2013-12-01

    We report a case of keratoacanthoma in a non-sun-exposed nasal vestibule of an 84-year-old man. He presented with a progressively growing left nasal mass that had been present for 8 months. Examination showed a non-tender protruding mass arising from medial vestibular wall of the left nostril. Histopathology indicated it was a keratoacanthoma. In an elderly patient with a history of a progressively growing mass in the nose, a differential diagnosis of malignancy should be ruled out, and histological conformation is essential. To our knowledge, only a very small number of cases of nasal vestibular keratoacanthoma have been reported. PMID:24376301

  13. Mitek Suspension of the Lateral Nasal Wall.

    Science.gov (United States)

    White, James R; Hamilton, Grant S

    2016-02-01

    The nasal valve has long been described as the anatomical boundary most likely to inhibit nasal airflow and lead to subsequent nasal obstruction. Although many procedures can address this area to improve the nasal airway, for over 20 years, suture lateralization of the external nasal valve has been described as a minimally invasive technique that can improve nasal breathing. We report our modification of the standard technique in which we lateralize the placement of the bone-anchored suture and incorporate Gore-Tex within the nasal vestibular incision to prevent tissue migration. PMID:26862966

  14. Reduction in drop size of ophthalmic topical drop preparations and the impact of treatment

    Directory of Open Access Journals (Sweden)

    Shiva Kumar

    2011-01-01

    Full Text Available In this work we devised a method to create smaller eye drops of the glaucoma medication timolol maleate by altering the dropper tip design and changing the physical properties of the formulation. Most ocular diseases are treated with topical application of eye drops. After instillation of an eye drop, typically, less than 5% of the applied drug penetrates the cornea and reaches the intraocular tissues; the major fraction of the instilled drug is absorbed and enters the systemic circulation. Ophthalmic solutions are available in multidose or single-dose glass/plastic dropper bottles that deliver drops with a volume that ranges from 25 μL to 70 μL (average 40 μL. Because of the low capacity of the precorneal area, the optimal drop volume is about 20 μL; with larger volumes there is the risk of adverse systemic effects due to absorption of the drug via the nasal mucosa. Thus, both from the biopharmaceutical and economic point of view, drops of only 5-15 mL volume should be instilled into the eye. In this present work we devised a method to reduce the size of the drop by inserting a glass capillary tube into the dropper tip and by changing the physical properties of the formulation (by altering the concentration of Tween 80™, i.e., 0.05% and 0.1% of Tween 80™. We measured the drop sizes of the different timolol eye drop formulations available in the market and estimated the yearly cost of the medications. Our timolol maleate formulation with 0.1% concentration of Tween 80™ delivered through the dropper tip with the inserted glass capillary was shown to be better than the other formulations available in the market in terms of ability to deliver smaller drops, meaning that each bottle would last longer and that the yearly cost of treatment would be lower.

  15. Bilateral cleft lip nasal deformity

    OpenAIRE

    Singh Arun; Nandini R.

    2009-01-01

    Bilateral cleft lip nose deformity is a multi-factorial and complex deformity which tends to aggravate with growth of the child, if not attended surgically. The goals of primary bilateral cleft lip nose surgery are, closure of the nasal floor and sill, lengthening of the columella, repositioning of the alar base, achieving nasal tip projection, repositioning of the lower lateral cartilages, and reorienting the nares from horizontal to oblique position. The multiplicity of procedures in the li...

  16. A entomoftorose nasal

    Directory of Open Access Journals (Sweden)

    Zilton A. Andrade

    1972-10-01

    Full Text Available São apresentados os dados clínico-patológicos de dois casos de entomoftorose nasal, nova doença humana causada por um ficomiceto - Entomophthora coronata. Os pacientes, uma menina e um homem, com 8 e 44 anos de idade respectivamente, apresentaram doença localizada, com nódulos no nariz e região paranasal, edema e deformação da face. O parasito foi isolado do primeiro caso, mas todas as tentativas para isolá-lo no segundo caso resultaram negativas. Histologicamente, havia reação granulomatosa, fibrose e edema, em torno de hifas não septadas, as quais exibiam envólucro eosinófilo amorfo em torno. Foram demonstrados anticorpos circulantes contra, as hifas do E. coronata no soro de um dos pacientes. O material eosinófilo em torno das hifas continha fibrina e material auto-fluorescente sob luz ultra-violeta, provavelmente lipofuscina, mas não foram demonstrados anticorpos ou antígenos nesta área. A apresentação destes casos, os primeiros a serem descritos no Brasil, é acompanhado, de uma revisão geral do assunto, pois tal poderá vir a ser de interesse para aqueles que estudam os problemas da patologia tropical em nosso meio.

  17. TEFLON NASAL SPLINTS IN NASAL SURGERIES: ADVANTAGES OVER CONVENTIONAL NASAL PACKING

    OpenAIRE

    Sudhir M Naik; Ravishankar, B.; T Shashikumar; T Deekshith; C Sherry; N Pooja; P.Sathya

    2014-01-01

    Background &Objectives: Nasal splints have long been used to prevent post operative nasal adhesions in septal surgery. But its efficacy in reducing adhesions and residual deviations are still controversial. Teflon is an inert material used as septal splints with sieves are used in our study as splints. Materials and methods: This is a comparative case series study done in 214 cases of septoplasties. 116 postoperative cases were packed with framycetin packs only and the other 98 cases ...

  18. Image diagnosis of nasal bone fracture

    International Nuclear Information System (INIS)

    Twenty cases of nasal bone fractures were evaluated as to the types of fractures based upon HRCT findings. Conventional X-Ray films for nasal bones were analyzed and compared with HRCT findings. Nasal bone fractures were classified into lateral and frontal fractures. HRCT images were evaluated in three planes including upper, middle and lower portions of the nasal bone. Fractures favored males of teens. Lateral fracture gave rise to the fractures of the nasal bone opposite to the external force, loosening of the ipsilateral nasomaxillary sutures and fractures of the frontal process of the maxilla. Conventional X-Ray films were reevaluated after HRCT evaluation and indications of nasal bone fractures were determined. In addition to the discontinuity of the nasal dorsum, fracture lines parallel to and beneath the nasal dorsum and indistinct fracture lines along the nasomaxillary sutures are the indication of nasal bone fractures by conventional X-Ray films. (author)

  19. TEFLON NASAL SPLINTS IN NASAL SURGERIES: ADVANTAGES OVER CONVENTIONAL NASAL PACKING

    Directory of Open Access Journals (Sweden)

    Sudhir M Naik

    2014-10-01

    Full Text Available Background &Objectives: Nasal splints have long been used to prevent post operative nasal adhesions in septal surgery. But its efficacy in reducing adhesions and residual deviations are still controversial. Teflon is an inert material used as septal splints with sieves are used in our study as splints. Materials and methods: This is a comparative case series study done in 214 cases of septoplasties. 116 postoperative cases were packed with framycetin packs only and the other 98 cases by framycetin packs and teflon septal splints. The groups were compared for postoperative nasal adhesions, residual deviation , pain , septal perforations and subjective patient satisfaction. Result: The rates of adhesion and pain on VAS scale showed no significant difference in the splinted and non splinted group. Pain was more with the splints even after pack removal. Residual deviation was reduced with these teflon nasal septal splints. Conclusion: Nasal septal splint does not significantly reduce the adhesions after septoplasty but are effective in reducing the residual deviations. The pain and discomfort are more with the splints. Post operative adhesions are better reduced by nasal irrigation and manual cleaning of the cavities by antibiotic ointments.

  20. 21 CFR 341.80 - Labeling of nasal decongestant drug products.

    Science.gov (United States)

    2010-04-01

    ... drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks... taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or...), (3), and (4)—(A) Nasal drops or sprays—For a 0.5-percent aqueous solution. Adults and children...

  1. Bilateral cleft lip nasal deformity

    Directory of Open Access Journals (Sweden)

    Singh Arun

    2009-01-01

    Full Text Available Bilateral cleft lip nose deformity is a multi-factorial and complex deformity which tends to aggravate with growth of the child, if not attended surgically. The goals of primary bilateral cleft lip nose surgery are, closure of the nasal floor and sill, lengthening of the columella, repositioning of the alar base, achieving nasal tip projection, repositioning of the lower lateral cartilages, and reorienting the nares from horizontal to oblique position. The multiplicity of procedures in the literature for correction of this deformity alludes to the fact that no single procedure is entirely effective. The timing for surgical intervention and its extent varies considerably. Early surgery on cartilage may adversely affect growth and development; at the same time, allowing the cartilage to grow in an abnormal position and contributing to aggravation of deformity. Some surgeons advocate correction of deformity at an early age. However, others like the cartilages to grow and mature before going in for surgery. With peer pressure also becoming an important consideration during the teens, the current trend is towards early intervention. There is no unanimity in the extent of nasal dissection to be done at the time of primary lip repair. While many perform limited nasal dissection for the fear of growth retardation, others opt for full cartilage correction at the time of primary surgery itself. The value of naso-alveolar moulding (NAM too is not universally accepted and has now more opponents than proponents. Also most centres in the developing world have neither the personnel nor the facilities for the same. The secondary cleft nasal deformity is variable and is affected by the extent of the original abnormality, any prior surgeries performed and alteration due to nasal growth. This article reviews the currently popular methods for correction of nasal deformity associated with bilateral cleft lip, it′s management both at the time of cleft lip repair

  2. Nasal trauma: Primary reconstruction with open rhinoplasty.

    Science.gov (United States)

    Konstantinidis, I; Malliari, H; Metaxas, S

    2011-01-01

    Due to the prominent location of the nose, the most common facial traumas are nasal injuries. Although nasal traumas usually require staged intervention at a later period of time, in selected cases, primary reconstruction can be effective. A 20-year-old man who was referred from the emergency department with nasal trauma is presented. He reported a fall after feeling unsteady, which caused a direct nasal injury. Clinical examination revealed septal fracture with obstruction of the left nasal cavity and deformity of the nasal pyramid (inverted V deformity). The patient also had a complete dissection of the columella skin. Epistaxis was self-limited, and an open rhinoplasty procedure was decided because the trauma occurred 1 h before admission and there was no significant edema. Surgical intervention included septal reconstruction combined with restoration of the nasal pyramid and columella. One month later, the patient had patent nasal airways, and he was satisfied with the aesthetic result. PMID:22942663

  3. High Flow Nasal Cannulae in preterm infants

    OpenAIRE

    F. Ciuffini; Colnaghi, M; A. Lavizzari; D. Mercadante; Musumeci, S; Mosca, F

    2013-01-01

    Despite of improved survival of premature infants, the incidence of long term pulmonary complications, mostly associated with ventilation-induced lung injury, remains high. Non invasive ventilation (NIV) is able to reduce the adverse effects of mechanical ventilation. Although nasal continuous positive airway pressure (NCPAP) is an effective mode of NIV, traumatic nasal complications and intolerance of the nasal interface are common. Recently high flow nasal cannula (HFNC) is emerging as an e...

  4. Bubble and drop interfaces

    CERN Document Server

    Miller

    2011-01-01

    The book aims at describing the most important experimental methods for characterizing liquid interfaces, such as drop profile analysis, bubble pressure and drop volume tensiometry, capillary pressure technique, and oscillating drops and bubbles. Besides the details of experimental set ups, also the underlying theoretical basis is presented in detail. In addition, a number of applications based on drops and bubbles is discussed, such as rising bubbles and the very complex process of flotation. Also wetting, characterized by the dynamics of advancing contact angles is discussed critically. Spec

  5. Nasal pulse oximetry overestimates oxygen saturation

    DEFF Research Database (Denmark)

    Rosenberg, J; Pedersen, M H

    1990-01-01

    Ten surgical patients were monitored with nasal and finger pulse oximetry (Nellcor N-200) for five study periods with alternating mouth and nasal breathing and switching of cables and sensors. Nasal pulse oximetry was found to overestimate arterial oxygen saturation by 4.7 (SD 1.4%) (bias...

  6. Does Post Septoplasty Nasal Packing Reduce Complications?

    Directory of Open Access Journals (Sweden)

    Bijan Naghibzadeh

    2011-01-01

    Full Text Available The main issues in nasal surgery are to stabilize the nose in the good position after surgery and preserve the cartilages and bones in the favorable situation and reduce the risk of deviation recurrence. Also it is necessary to avoid the synechia formation, nasal valve narrowing, hematoma and bleeding. Due to the above mentioned problems and in order to solve and minimize them nasal packing, nasal splint and nasal mold have been advised. Patients for whom the nasal packing used may faced to some problems like naso-pulmonary reflex, intractable pain, sleep disorder, post operation infection and very dangerous complication like toxic shock syndrome. We have two groups of patients and three surgeons (one of the surgeons used post operative nasal packing in his patients and the two others surgeons did not.Complications and morbidities were compared in these two groups. Comparing the two groups showed that the rate of complication and morbidities between these two groups were same and the differences were not valuable, except the pain and discomfort post operatively and at the time of its removal. Nasal packing has several risks for the patients while its effects are not studied. Septoplasty can be safely performed without postoperative nasal packing. Nasal packing had no main findings that compensated its usage. Septal suture is one of the procedures that can be used as alternative method to nasal packing. Therefore the nasal packing after septoplasty should be reserved for the patients with increased risk of bleeding.

  7. Immunophenotype Heterogeneity in Nasal Glomangiopericytoma

    Directory of Open Access Journals (Sweden)

    Adriana Handra-Luca

    2015-01-01

    Full Text Available Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years presented with a left nasal tumefaction. The resected specimen (1.5-cm showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.

  8. Diagnostic strategies in nasal congestion

    Directory of Open Access Journals (Sweden)

    John Krouse

    2010-02-01

    Full Text Available John Krouse1, Valerie Lund2, Wytske Fokkens3, Eli O Meltzer41Temple University School of Medicine, Philadelphia, PA, USA; 2Ear Institute, University College London, UK; 3Department of Otorhinolaryngology, Amsterdam Medical Centre, Netherlands; 4Allergy and Asthma Medical Group and Research Center, San Diego, CA and Department of Pediatrics, University of California, San Diego, USAAbstract: Nasal congestion is a major symptom of upper respiratory tract disorders, and its characterization an important part of the diagnosis of these illnesses. Patient history and assessment of nasal symptoms are essential components of diagnosis, providing an initial evaluation that may be adequate to rule out serious conditions. However, current congestion medications are not always fully effective. Thus, if symptoms do not respond adequately to therapy, or symptoms suggestive of more serious conditions are present, specialized assessments may be needed. Various techniques are available for diagnosing patients, including those used chiefly by primary care clinicians and those requiring the expertise of otolaryngologists, allergists, and other specialists. Endoscopy remains a mainstay for evaluating nasal blockage and its causes, while modalities such as peak nasal inspiratory flow and acoustic rhinometry are evolving to provide easy-to-use, noninvasive procedures that are sensitive enough to measure small but clinically important abnormalities and therapeutic changes. Several imaging modalities are available to the specialist for severe or unusual cases, as are specialized diagnostic procedures that measure adjunctive features of congestion, such as impaired mucociliary function.Keywords: allergic rhinitis, congestion, diagnosis, obstruction, rhinosinusitis

  9. Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    Stevens, Whitney W; Schleimer, Robert P; Kern, Robert C

    2016-01-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females, but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis, but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease. PMID:27393770

  10. Nasal Schwannoma: a case report

    Directory of Open Access Journals (Sweden)

    Siu-Navarro YJ, Pérez-Carbajal AJ

    2013-10-01

    Full Text Available Introduction: Schwannomas are benign tumors that arise from Schwann cells peripheral nerves sheath. About 25-45% occur in the head and neck and only 4% of these tumors involve the sinunasal tract.Objective: To provide, through a clinic case and lecture review, the clinical and radiopatology findings of a bening and unusual tumors, as are the Nasal schwannomas. Case Report: We report a case of a young woman with nasal schwannoma, who complain of left nasal obstruction and rhinorrhea, which after subsequent imaging studies, surgical and pathology analisis, diagnosis was found. Sustained a favorable clinical evolution.Results and Discussion: The clinic and radiologic findings are nonspecific, depend upon the location or size of the tumor and subsequent involvement of surrounding structures, but generally present as a mass with less agressive behavior. The elective treatment is surgery, confirming this disease by microscopic and immunohistochemistry studies.Conclusion: Given these aspects must be considered nasal schwannomas within the differential diagnosis of a tumor with less aggressive behavior, clinical-radiological, because implies good results for the patient and unusual recurrence after surgery.

  11. Paramagnetic Leidenfrost Drops

    CERN Document Server

    Piroird, Keyvan; Clanet, Christophe; Quéré, David

    2010-01-01

    We present a fluid dynamics video showing the behavior of drops of liquid oxygen, at room temperature. Due to their low boiling point, these drops levitate on a cushion of their own vapour. This property gives them a high mobility, as known more generally in such Leidenfrost situations. But liquid oxygen is also paramagnetic, and thus likely to be manipulated using a magnet. It is first shown that the shape of the drop can be modified by changing the drop/magnet distance; approaching the magnet acts as reinforcing gravity, so that the drops get flattened by this action. The transformation is of course reversible: as the magnet is withdrawn, the liquid recovers its quasi-spherical shape. Magnets can also be used to trap the oxygen drops. As they pass above a magnet, they slow down significantly, a consequence of their deformation: despite a very low friction, the vibrations induced by the drop deformations represent an important source of dissipation: below a well-defined velocity, drops can even be stopped in...

  12. Turbulence, bubbles and drops

    NARCIS (Netherlands)

    Veen, van der Roeland Cornelis Adriaan

    2016-01-01

    In this thesis, several questions related to drop impact and Taylor-Couette turbulence are answered. The deformation of a drop just before impact can cause a bubble to be entrapped. For many applications, such as inkjet printing, it is crucial to control the size of this entrapped bubble. To study t

  13. Idiopathic calcinosis cutis of nasal dorsum

    Directory of Open Access Journals (Sweden)

    Shrinath D.P Kamath

    2012-01-01

    Full Text Available A 23-year-old lady presented with a slowly progressing firm mass on the nasal dorsum since 8 months. Her biochemical, haematological and collagen vascular disease screening tests were normal. Radiographs of the nasal bones showed a subcutaneous calcifying lesion with no evidence of nasal bone erosion. A diagnosis of idiopathic calcinosis cutis (ICC was made. The mass was excised and soft tissue defect was augmented with silicone prosthesis. The histopathology with the haematoxylin and eosin staining and von Kossa stain confirmed the diagnosis of calcinosis cutis. This is an unusual presentation of ICC involving the nasal dorsum requiring surgery and nasal dorsal augmentation with silicone prosthesis.

  14. Nasal Septum Perforation due to Methamphetamine abuse

    Directory of Open Access Journals (Sweden)

    Mehdi Bakhshaee

    2012-07-01

    Full Text Available Introduction: Spontaneous Perforation of the nasal septum is an uncommon condition. Nasal inhalation of substances such as cocaine has long been linked to this Perforation. Case Report: This report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.This is the first reported case of nasal septal necrosis linked to nasal inhalation of methamphetamine. Conclusions: Patient history and assurance regardingillegal drug consumption and abuse is a key point for fast and accurate diagnosis. The pathophysiology of drug-induced sinunasal disease and a review of the literature are also presented.

  15. Sessile Rayleigh drop instability

    Science.gov (United States)

    Steen, Paul; Bostwick, Josh

    2012-11-01

    Rayleigh (1879) determined the mode shapes and frequencies of the inviscid motion of a free drop held by surface tension. We study the inviscid motions of a sessile Rayleigh drop - a drop which rests on a planar solid and whose contact-line is free to move. Linear stability analysis gives the modes and frequencies of the droplet motions. In this talk, we focus on the ``walking instability,'' an unstable mode wherein the drop moves across a planar substrate in an inviscid rocking-like motion. The mode shape is non-axisymmetric. Although the experimental literature has hinted at such a mode, this is the first prediction from linear stability analysis, as far as we are aware. The ``walking instability'' of the drop converts energy stored in the liquid shape into the energy of liquid motion - which represents a heretofore unknown pathway of energy conversion of potentially wide significance for a broad range of applications.

  16. Effect of nasal decongestion on voice spectrum of a nasal consonant-vowel.

    Science.gov (United States)

    Lee, Guo-She; Yang, Cheryl C H; Wang, Ching-Ping; Kuo, Terry B J

    2005-03-01

    The nasal cavity and its related structures make significant contributions to human phonation, especially the resonance of voice spectra. The voice spectra of the nasal consonant-vowel (CV), [md:], in the subjects with nasal obstruction were obtained and were compared with the spectra of the same CV vocalized by the same subjects after topical nasal decongestion treatment with 1:1000 epinephrine solution. Results revealed that the intensity damping was more marked in the high-frequency area (>1600 Hz) after the nasal decongestion. Moreover, the intensities of the spectral valleys damped more than the spectral peaks, especially the spectral valley of 1000-2700 Hz. Therefore, a more complex spectral pattern was formed by the resultant uneven damping effect after nasal decongestion. The nasal cavity plays an important role in the formation of spectral peaks and valleys, and such engraved voice spectra may also characterize nasal voices like the nasal CV [md:] demonstrated in our study. PMID:15766851

  17. Primary Nasal Reconstruction in Self-Inflicted Nasal Injury.

    Science.gov (United States)

    Kapadia, Abizer; John, Jerry R; Gaba, Sunil; Sharma, Ramesh Kumar

    2015-10-01

    Self-inflicted injury of the nose is extremely rare. It may be associated with severe psychopathology and suicidal ideation. The authors report a case of a 24-year-old man, who presented with soft-tissue loss over both the alae of his nose. He had cut off the alar rims with an ordinary razor blade. He was overtly concerned about his nose being excessively broad and fat. A diagnosis of body dysmorphic disorder with nonsuicidal self-injury was made. Patient was observed during 72 hours in hospital with psychiatric support and local dressings. The authors undertook primary nasal reconstruction with nasolabial flaps on both sides for coverage. In conclusion, self-inflicted nasal injury mandates a judicious balancing of psychiatric support and surgical reconstruction. This can prevent untoward sequelae including further self-harm and suicide. PMID:26468831

  18. Contrastive and contextual vowel nasalization in Ottawa

    Science.gov (United States)

    Klopfenstein, Marie

    2005-09-01

    Ottawa is a Central Algonquian language that possesses the recent innovation of contrastive vowel nasalization. Most phonetic studies done to date on contrastive vowel nasalization have investigated Indo-European languages; therefore, a study of Ottawa could prove to be a valuable addition to the literature. To this end, a percentage of nasalization (nasal airflow/oral + nasal airflow) was measured during target vowels produced by native Ottawa speakers using a Nasometer 6200-3. Nasalized vowels in the target word set were either contrastively or contextually nasalized: candidates for contextual nasalization were either regressive or perserverative in word-initial and word-final syllables. Subjects were asked to read words containing target vowels in a carrier sentence. Mean, minimum, and maximum nasalance were obtained for each target vowel across its full duration. Target vowels were compared across context (regressive or perseverative and word-initial or word-final). In addition, contexts were compared to determine whether a significant difference existed between contrastive and contextual nasalization. Results for Ottawa will be compared with results for vowels in similar contexts in other languages including Hindi, Breton, Bengali, and French.

  19. Drop Tower Workshop

    Science.gov (United States)

    Urban, David

    2013-01-01

    Ground based microgravity facilities are an important proving ground for space experiments, ground-based research and space hardware risk mitigation. An overview of existing platforms will be discussed with an emphasis on drop tower capabilities. The potential for extension to partial gravity conditions will be discussed. Input will be solicited from attendees for their potential to use drop towers in the future and the need for enhanced capabilities (e.g. partial gravity)

  20. Effect of Nasal Obstruction on Continuous Positive Airway Pressure Treatment: Computational Fluid Dynamics Analyses.

    Directory of Open Access Journals (Sweden)

    Tadashi Wakayama

    Full Text Available Nasal obstruction is a common problem in continuous positive airway pressure (CPAP therapy for obstructive sleep apnea and limits treatment compliance. The purpose of this study is to model the effects of nasal obstruction on airflow parameters under CPAP using computational fluid dynamics (CFD, and to clarify quantitatively the relation between airflow velocity and pressure loss coefficient in subjects with and without nasal obstruction.We conducted an observational cross-sectional study of 16 Japanese adult subjects, of whom 9 had nasal obstruction and 7 did not (control group. Three-dimensional reconstructed models of the nasal cavity and nasopharynx with a CPAP mask fitted to the nostrils were created from each subject's CT scans. The digital models were meshed with tetrahedral cells and stereolithography formats were created. CPAP airflow simulations were conducted using CFD software. Airflow streamlines and velocity contours in the nasal cavities and nasopharynx were compared between groups. Simulation models were confirmed to agree with actual measurements of nasal flow rate and with pressure and flow rate in the CPAP machine.Under 10 cmH2O CPAP, average maximum airflow velocity during inspiration was 17.6 ± 5.6 m/s in the nasal obstruction group but only 11.8 ± 1.4 m/s in the control group. The average pressure drop in the nasopharynx relative to inlet static pressure was 2.44 ± 1.41 cmH2O in the nasal obstruction group but only 1.17 ± 0.29 cmH2O in the control group. The nasal obstruction and control groups were clearly separated by a velocity threshold of 13.5 m/s, and pressure loss coefficient threshold of approximately 10.0. In contrast, there was no significant difference in expiratory pressure in the nasopharynx between the groups.This is the first CFD analysis of the effect of nasal obstruction on CPAP treatment. A strong correlation between the inspiratory pressure loss coefficient and maximum airflow velocity was found.

  1. Nasal airway responses to nasal continuous positive airway pressure breathing: An in-vivo pilot study.

    Science.gov (United States)

    White, David E; Bartley, Jim; Shakeel, Muhammad; Nates, Roy J; Hankin, Robin K S

    2016-06-14

    The nasal cycle, through variation in nasal airflow partitioning, allows the upper airway to accommodate the contrasting demands of air conditioning and removal of entrapped air contaminants. The purpose of this study was to investigate the influence of nasal continuous positive airway pressure (nCPAP) breathing has on both nasal airflow partitioning and nasal geometry. Using a custom-made nasal mask, twenty healthy participants had the airflow in each naris measured during normal nasal breathing followed by nCPAP breathing. Eight participants also underwent magnetic resonance imaging (MRI) of the nasal region during spontaneous nasal breathing, and then nCPAP breathing over a range of air pressures. During nCPAP breathing, a simultaneous reduction in airflow through the patent airway together with a corresponding increase in airway flow within the congested nasal airway were observed in sixteen of the twenty participants. Nasal airflow resistance is inversely proportional to airway cross-sectional area. MRI data analysis during nCPAP breathing confirmed airway cross-sectional area reduced along the patent airway while the congested airway experienced an increase in this parameter. During awake breathing, nCPAP disturbs the normal inter-nasal airflow partitioning. This could partially explain the adverse nasal drying symptoms frequently reported by many users of this therapy. PMID:27173595

  2. Nasal leech infestation causing persistent epistaxis

    OpenAIRE

    Sarathi, Kalra

    2011-01-01

    Foreign bodies in the nasal cavity are commonly encountered as a cause of epistaxis; however, nasal leech infestation as a cause of unilateral persistent epistaxis is very rare. Examination of nasal cavity revealed fleshy material in the left nostril, which was identified as leech. The leech was removed with the help of an artery forceps following irrigation of the left nostril with normal saline and adopting wait-and-watch policy. In developing countries, leech infestation as a cause of epis...

  3. [Review: pathophysiology and methodology of nasal packing].

    Science.gov (United States)

    Beule, A G; Weber, R K; Kaftan, H; Hosemann, W

    2004-08-01

    Nasal packing is a frequent procedure to control spontaneous nasal bleeding or postoperative oozing following different types of nasal surgery. It strives for internal stabilization of the nasal framework and for optimizing wound healing by prevention of stenosis or synechia. A lot of different materials is used and there is no accepted standard concerning the type and application. A review on pathophysiology of the packed nose is given together with a survey on customary packing materials focussing on the specific merits, demerits and side-effects including economical aspects. PMID:15316896

  4. Nasal Myiasis in Hinduism and Contemporary Otorhinolaryngology.

    Science.gov (United States)

    Bosmia, Anand N; Zimmermann, Terence M; Griessenauer, Christoph J; Shane Tubbs, R; Rosenthal, Eben L

    2014-01-01

    Various case reports on nasal myiasis written during the 1990s and 2000s state that nasal myiasis, which is known as peenash among South Asian natives, is a form of divine punishment in Hindu mythology, but do not provide citations from Hindu scriptures that would suggest this interpretation. This paper aims to discuss the phenomenon of peenash in a historical context by examining medical literature written during the nineteenth and early twentieth centuries, to identify Hindu texts contributing to the belief of some Hindus that nasal myiasis is a form of divine punishment, and to provide an overview of contemporary treatment for and management of nasal myiasis. PMID:24385004

  5. Drying drops of blood

    Science.gov (United States)

    Brutin, David; Sobac, Benjamin; Loquet, Boris; Sampol, José.

    2010-11-01

    The drying of a drop of human blood is fascinating by the complexity of the physical mechanisms that occur as well as the beauty of the phenomenon which has never been previously evidenced in the literature. The final stage of full blood evaporation reveals for a healthy person the same regular pattern with a good reproducibility. Other tests on anemia and hyperlipidemic persons were performed and presented different patterns. By means of digital camera, the influence of the motion of red blood cells (RBCs) which represent about 50% of the blood volume, is revealed as well as its consequences on the final stages of drying. The mechanisms which lead to the final pattern of dried blood drops are presented and explained on the basis of fluid and solid mechanics in conjunction with the principles of hematology. Our group is the first to evidence that the specific regular patterns characteristic of a healthy individual do not appear in a dried drop of blood from a person with blood disease. Blood is a complex colloidal suspension for which the flow motion is clearly non-Newtonian. When drops of blood evaporate, all the colloids are carried by the flow motion inside the drop and interact.

  6. Nasal and Oral Consonant Similarity in Speech Errors: Exploring Parallels with Nasal Consonant Harmony

    Science.gov (United States)

    Walker, Rachel

    2007-01-01

    Previous research has found that "similar" sounds interact in phonological nasal consonant harmony, wherein certain consonants become nasals when the word contains a nasal (e.g., Kikongo: /-kun-idi/ [right arrow] [-kun-ini] "planted"). Across languages, stops and approximants are chiefly affected, especially voiced consonants and ones that match…

  7. Lambda-dropping

    DEFF Research Database (Denmark)

    Danvy, Olivier; Schultz, Ulrik Pagh

    1997-01-01

    ;rbæk's case study presented at PEPM '95, most polyvariant specializers for procedural programs operate on recursive equations. To this end, in a pre-processing phase, they lambda-lift source programs into recursive equations, As a result, residual programs are also expressed as recursive equations, often......Lambda-lifting a functional program transforms it into a set of recursive equations. We present the symmetric transformation: lambda-dropping. Lambda-dropping a set of recursive equations restores block structure and lexical scope.For lack of scope, recursive equations must carry around all...... with dozens of parameters, which most compilers do not handle efficiently. Lambda-dropping in a post-processing phase restores their block structure and lexical scope thereby significantly reducing both the compile time and the run time of residual programs....

  8. Impact of granular drops

    KAUST Repository

    Marston, J. O.

    2013-07-15

    We investigate the spreading and splashing of granular drops during impact with a solid target. The granular drops are formed from roughly spherical balls of sand mixed with water, which is used as a binder to hold the ball together during free-fall. We measure the instantaneous spread diameter for different impact speeds and find that the normalized spread diameter d/D grows as (tV/D)1/2. The speeds of the grains ejected during the “splash” are measured and they rarely exceed twice that of the impact speed.

  9. Changes in nasal resistance and nasal geometry using pressure and acoustic rhinometry in a feline model of nasal congestion

    DEFF Research Database (Denmark)

    McLeod, R.L.; Mingo, G.G.; Herczku, C.;

    1999-01-01

    This is the first report describing the use and pharmacological characterization of nasal patency by both pressure rhinometry and acoustic rhinometry (AcR) in an experimental cat model of nasal congestion. In pressure rhinometry studies, aerosolized compound 48/80 (0.1-3.0%), a mast cell liberato...

  10. Neurilemmoma of lateral nasal wall

    Directory of Open Access Journals (Sweden)

    Jyotsna Naresh Bharti

    2015-06-01

    Full Text Available Neurilemmoma is a benign tumour of nerve sheath origin that can arise from myelinated nerve. The Head and neck is the most frequent site involved and other sites are scalp, face, oral cavity, pharynx, larynx, trachea and ear. Neurilemmoma usually occur as solitary lesions and in association with NF type 2. Malignant transformation is very rare. We report a case of 18 year old male presented with complaint of nasal obstruction and swelling in right side of nose. We discuss the clinical presentation, histologic features, and therapeutic options for such a rare benign lesion.

  11. Numbered nasal discs for waterfowl

    Science.gov (United States)

    Bartonek, J.C.; Dane, C.W.

    1964-01-01

    Numbered nasal discs were successfully used in studies requiring large numbers of individually marked waterfowl. The procedure for constructing these discs is outlined. Blue-winged teal (Anas discors) with 5/8-inch discs, and canvasback (Aythya valisineria) and redhead (A. americana) with 3/4-inch discs can be individually identified up to 50 and 80 yards, respectively, with a gunstock-mounted, 20-power spotting scope. The particular value of these markers is their durability, the number of combinations possible, and the apparent absence of behavioral or mortality influence among such species as the blue-winged teal.

  12. Coalescence of sessile drops

    CERN Document Server

    Nikolayev, Vadim; Pomeau, Yves; Andrieu, Claire

    2016-01-01

    We present an experimental and theoretical description of the kinetics of coalescence of two water drops on a plane solid surface. The case of partial wetting is considered. The drops are in an atmosphere of nitrogen saturated with water where they grow by condensation and eventually touch each other and coalesce. A new convex composite drop is rapidly formed that then exponentially and slowly relaxes to an equilibrium hemispherical cap. The characteristic relaxation time is proportional to the drop radius R * at final equilibrium. This relaxation time appears to be nearly 10 7 times larger than the bulk capillary relaxation time t b = R * $\\eta$/$\\sigma$, where $\\sigma$ is the gas--liquid surface tension and $\\eta$ is the liquid shear viscosity. In order to explain this extremely large relaxation time, we consider a model that involves an Arrhenius kinetic factor resulting from a liquid--vapour phase change in the vicinity of the contact line. The model results in a large relaxation time of order t b exp(L/R...

  13. An order drop theorem

    Directory of Open Access Journals (Sweden)

    Mihai Turinici

    2006-11-01

    Full Text Available A drop theorem on ordered metric spaces is established from the (pre order version of Ekeland’s variational principle in Turinici [An St UAIC Ia (Math, 36 (1990, 329-352]. The logical equivalence between these results is also discussed.

  14. An order drop theorem

    OpenAIRE

    Mihai Turinici

    2006-01-01

    A drop theorem on ordered metric spaces is established from the (pre) order version of Ekeland’s variational principle in Turinici [An St UAIC Ia (Math), 36 (1990), 329-352]. The logical equivalence between these results is also discussed.

  15. NASAL INVERTED PAPILLOMA OF UNUSUAL ORIGIN

    Directory of Open Access Journals (Sweden)

    kasim s. kasim

    2013-12-01

    Full Text Available Two cases of Schneiderian papilloma of the nasal septum are presented. The condition is rare, as indicated by a review of previously published cases. The clinical course of the lesion suggests that it behaves like Schneiderian papillomas elsewhere in the nasal cavity and paranasal sinuses. The need for aggressive surgical management and careful follow-up is emphasized.

  16. Chronic Rhinosinusitis without Nasal Polyps.

    Science.gov (United States)

    Cho, Seong Ho; Kim, Dae Woo; Gevaert, Philippe

    2016-01-01

    Chronic rhinosinusitis without nasal polyps (CRSsNP) is more prevalent than chronic rhinosinusitis with nasal polyps (CRSwNP). Certain diseases predispose to whereas others are associated with CRSsNP. Predisposing diseases include allergic and nonallergic upper and lower airway diseases, epithelial cell disorders, immunodeficiencies, autoimmune diseases, and some infectious diseases. In addition, environmental and host factors, examples of which include smoking, a higher incidence of abnormal biofilms, and innate immune defects, play a role in the pathogenesis of this disease. CRSsNP is characterized by histologic abnormalities, including basement membrane thickening (fibrosis) and goblet cell hyperplasia. Neutrophils and several chemokines, TGF-β and C-X-C motif chemokine ligand (CXCL)-8, play a role in CRSsNP remodeling. However, there are conflicting data about CRSsNP endotypes, for example, whether it is characterized by neutrophilia or eosinophilia or both. In spite of advancements and the understanding of the pathogenesis of this disease, additional study is necessary to better comprehend its underlying mechanisms, endotypes, and evidence-based treatment strategies. PMID:27393771

  17. Encapsulating Ellipsoids in Drops

    Science.gov (United States)

    Norton, Michael; Brugarolas, Teresa; Chou, Jonathan; Bau, Haim; Lee, Daeyeon

    2012-11-01

    Large aspect ratio particles were produced by embedding spherical polystyrene particles within a polymer film and subsequently heating and stretching the film. Particles were released by dissolving the film. Using a flow-focusing device, the elongated particles were partially encapsulated within droplets of fluid A, such as water, surrounded by an immiscible fluid B, such as oil. Drop volumes were controlled by adjusting the flow rates of fluids A and B. The contact angle was adjusted indirectly by varying the amount of surfactant adsorbed to the particle surface. The encapsulation process was visualized with a high-speed video camera. We observed cases ranging from partial to complete encapsulation and examined experimentally and theoretically the shape of the interface between fluid A and fluid B as a function of the drop volume. The numerically predicted position of the pinning line and the shape of the drop were compared to experimentally produced conformations and agreed favorably. This work was supported by ITMAT (UL1RR024134 from the NCRR) and the Penn MRSEC (NSF DMR-1120901).

  18. Coalescence of Liquid Drops

    CERN Document Server

    Eggers, J; Stone, H A; Eggers, Jens; Lister, John R.; Stone, Howard A.

    1999-01-01

    When two drops of radius $R$ touch, surface tension drives an initially singular motion which joins them into a bigger drop with smaller surface area. This motion is always viscously dominated at early times. We focus on the early-time behavior of the radius $\\rmn$ of the small bridge between the two drops. The flow is driven by a highly curved meniscus of length $2\\pi \\rmn$ and width $\\Delta\\ll\\rmn$ around the bridge, from which we conclude that the leading-order problem is asymptotically equivalent to its two-dimensional counterpart. An exact two-dimensional solution for the case of inviscid surroundings [Hopper, J. Fluid Mech. ${\\bf 213}$, 349 (1990)] shows that R)]$; and thus the same is true in three dimensions. The case of coalescence with an external viscous fluid is also studied in detail both analytically and numerically. A significantly different structure is found in which the outer fluid forms a toroidal bubble of radius $\\Delta \\propto \\rmn^{3/2}$ at the meniscus and $\\rmn \\sim (t\\gamma/4\\pi\\eta)...

  19. Three-dimensional Evaluation of Nasal Surgery in Patients with Obstructive Sleep Apnea

    Institute of Scientific and Technical Information of China (English)

    Dan-Mo Cui; De-Min Han; Busaba Nicolas; Chang-Long Hu; Jun Wu; Min-Min Su

    2016-01-01

    Background:Obstructive sleep apnea (OSA) is a common sleep disorder and is characterized by airway collapse at multiple levels of upper airway.The effectiveness of nasal surgery has been discussed in several studies and shows a promising growing interest.In this study,we intended to evaluate the effects of nasal surgery on the upper airway dimensions in patients with OSA using three-dimensional (3D)reconstruction of cone-beam computed tomography (CT).Methods:Twelve patients with moderate to severe OSA who underwent nasal surgery were included in this study.All patients were diagnosed with OSA using polysomnography (PSG) in multi sleep health centers associated with Massachusetts General Hospital,Massachusetts Eye and Ear Infirmary and the Partners Health Care from May 31,2011 to December 14,2013.The effect of nasal surgery was evaluated by the examination of PSG,subjective complains,and 3D reconstructed CT scan.Cross-sectional area was measured in eleven coronal levels,and nasal cavity volume was evaluated from anterior nasal spine to posterior nasal spine.The thickness of soft tissue in oral pharynx region was also measured.Results:Five out of the 12 patients were successfully treated by nasal surgery,with more than 50% drop of apnea-hypopnea index.All the 12 patients showed significant increase of cross-sectional area and volume postoperatively.The thickness of soft tissue in oral pharynx region revealed significant decrease postoperatively,which decreased from 19.14 ± 2.40 cm2 and 6.11 ± 1.76 cm2 to 17.13 ± 1.91 cm2 and 5.22 ± 1.20 cm2.Conclusions:Nasal surgery improved OSA severity as measured by PSG,subjective complaints,and 3D reconstructed CT scan.3D assessment of upper airway can play an important role in the evaluation of treatment outcome.

  20. Nasal Septal Deviation and Facial Skeletal Asymmetries.

    Science.gov (United States)

    Hartman, Christopher; Holton, Nathan; Miller, Steven; Yokley, Todd; Marshall, Steven; Srinivasan, Sreedevi; Southard, Thomas

    2016-03-01

    During ontogeny, the nasal septum exerts a morphogenetic influence on the surrounding facial skeleton. While the influence of the septum is well established in long snouted animal models, its role in human facial growth is less clear. If the septum is a facial growth center in humans, we would predict that deviated septal growth would be associated with facial skeletal asymmetries. Using computed tomographic (CT) scans of n = 55 adult subjects, the purpose of this study was to test whether there is a correlation between septal deviation and facial asymmetries using three-dimensional (3D) geometric morphometric techniques. We calculated deviation as a percentage of septal volume relative to the volume of a modeled non-deviated septum. We then recorded skeletal landmarks representing the nasal, palatal, and lateral facial regions. Landmark data were superimposed using Procrustes analysis. First, we examined the correlation between nasal septal deviation and the overall magnitude of asymmetry. Next, we assessed whether there was a relationship between nasal septal deviation and more localized aspects of asymmetry using multivariate regression analysis. Our results indicate that while there was no correlation between septal deviation and the overall magnitude of asymmetry, septal deviation was associated with asymmetry primarily in the nasal floor and the palatal region. Septal deviation was unassociated with asymmetries in the lateral facial skeleton. Though we did not test the causal relationship between nasal septal deviation and facial asymmetry, our results suggest that the nasal septum may have an influence on patterns of adult facial form. PMID:26677010

  1. Nasal continuous positive airway pressure

    DEFF Research Database (Denmark)

    Scholze, Alexandra; Lamwers, Stephanie; Tepel, Martin;

    2012-01-01

    Obstructive sleep apnoea (OSA) is linked to increased cardiovascular risk. This risk can be reduced by nasal continuous positive airway pressure (nCPAP) treatment. As OSA is associated with an increase of several vasoconstrictive factors, we investigated whether nCPAP influences the digital volume...... pulse wave. We performed digital photoplethysmography during sleep at night in 94 consecutive patients who underwent polysomnography and 29 patients treated with nCPAP. Digital volume pulse waves were obtained independently of an investigator and were quantified using an algorithm for continuous.......01; n = 94) and the arousal index (Spearman correlation, r = 0.21; p CPAP treatment, the AHI was significantly reduced from 27 ± 3 events · h(-1) to 4 ± 2 events · h(-1) (each n = 29; p

  2. Canine and feline nasal neoplasia.

    Science.gov (United States)

    Malinowski, Christine

    2006-05-01

    Dogs and cats of our society have outgrown their status as merely pets and are now considered our close companions and even family members. This shift in their roles has led to pet owners seeking improved preventative medicine for their four-legged friends. Subsequently, dogs and cats are living longer lives than ever before and developing more old-age-related diseases. One of the most devastating diseases of older animals is cancer. Once a veterinarian has detected cancer in a pet, pet owners seek advice on their next course of action. This article is intended to provide concise information regarding the diagnosis and treatment of intranasal tumors of the dog and cat. This article outlines the forms of nasal tumors that are the most common, the recommended imaging and biopsy techniques to diagnose the tumor, and the most appropriate treatments of them. PMID:16711615

  3. Nasal mass removal in the koala (Phascolarctos cinereus).

    Science.gov (United States)

    Bercier, Marjorie; Wynne, Janna; Klause, Stephen; Stadler, Cynthia K; Gorow, April; Pye, Geoffrey W

    2012-12-01

    Nasal masses in the koala (Phascolarctos cinereus) are not uncommon and can be challenging to diagnose and treat. Differential diagnoses for nasal masses in the koala are cryptococcal granulomas, nasal polyps, nasal adenocarcinoma, and osteochondromatosis. This report describes successful surgical approaches for two adult koalas with nasal masses and includes photodocumentation and description of the anatomy of the koala nasal passages from the postmortem transverse sectioning of a normal koala head. Surgical removal of the nasal masses in these koalas resulted in a rapid resolution of clinical signs.

  4. Plastinated nasal model: a new concept of anatomically realistic cast.

    OpenAIRE

    Durand, Marc; Pourchez, Jérémie; Louis, Bruno; Pouget, Jean-François; Isabey, Daniel; Coste, André; Prades, Jean-Michel; Rusch, Philippe; Cottier, Michèle

    2011-01-01

    BACKGROUND: For many years, researchers have been interested in investigating airflow and aerosol deposition in the nasal cavities. The nasal airways appear to be a complex geometrical system. Thus, in vitro experimental studies are frequently conducted with a more or less biomimetic nasal replica. AIM: This study is devoted to the development of an anatomically realistic nose model with bilateral nasal cavities, i.e. nasal anatomy, airway geometry and aerodynamic properties as close as possi...

  5. Model demonstrates functional purpose of the nasal cycle

    OpenAIRE

    White, David E.; Bartley, Jim; Nates, Roy J

    2015-01-01

    Background Despite the occurrence of the nasal cycle being well documented, the functional purpose of this phenomenon is not well understood. This investigation seeks to better understand the physiological objective of the nasal cycle in terms of airway health through the use of a computational nasal air-conditioning model. Method A new state-variable heat and water mass transfer model is developed to predict airway surface liquid (ASL) hydration status within each nasal airway. Nasal geometr...

  6. Nasal Chondromesenchymal Hamartoma in a Child

    International Nuclear Information System (INIS)

    Nasal chondromesenchymal hamartoma (NCMH) is a benign tumor that was described in 1998. The occurrence of this lesion in the nasal cavity of infants and children is especially rare, with only 21 cases reported in the international literature. We report a 12-month-old boy with respiratory distress due to nasal obstruction. Computed tomographic scan and magnetic resonance imaging examination demonstrated a soft-tissue mass obstructing the left nasal cavity. Digital subtraction angiography and preoperative superselective embolization with microparticles were also performed. The tumor was completely resected surgically. Histopathology and immunohistochemical analyses of the tumor disclosed a NCMH. The imaging characteristics of the tumor are described and the radiology literature is reviewed.

  7. Nasal septal teratoma in a child

    Directory of Open Access Journals (Sweden)

    Akinyemi Oluwole A

    2007-05-01

    Full Text Available Abstract Background Teratoma is a rare developmental neoplasm that arises from totipotential tumor stem cells. Head and neck teratomas constitute about 10% of all cases. Only two cases of mature teratoma of the nasal septum have previously been documented in the world literature. Case presentation We present a case of histologically confirmed mature teratoma arising from the nasal septum in an eighteen month old Nigerian female who presented with a history of noisy breathing associated with recurrent rhinorrhea since birth. Physical examination revealed obstruction of the right nasal cavity by a pale fleshy mass. She underwent a total surgical excision and to date, after thirty one months follow-up, she is free from recurrence. Conclusion The prognosis for benign teratoma of the nasal septum is good following total surgical excision.

  8. Discriminating between Nasal and Mouth Breathing

    OpenAIRE

    Curran, Kevin; Yuan, Peng; Coyle, Damian

    2010-01-01

    The recommendation to change breathing patterns from the mouth to the nose can have a significantly positive impact upon the general well being of the individual. We classify nasal and mouth breathing by using an acoustic sensor and intelligent signal processing techniques. The overall purpose is to investigate the possibility of identifying the differences in patterns between nasal and mouth breathing in order to integrate this information into a decision support system which will form the b...

  9. Numerical simulation and nasal air-conditioning

    Directory of Open Access Journals (Sweden)

    Keck, Tilman

    2010-01-01

    Full Text Available Heating and humidification of the respiratory air are the main functions of the nasal airways in addition to cleansing and olfaction. Optimal nasal air conditioning is mandatory for an ideal pulmonary gas exchange in order to avoid desiccation and adhesion of the alveolar capillary bed. The complex three-dimensional anatomical structure of the nose makes it impossible to perform detailed in vivo studies on intranasal heating and humidification within the entire nasal airways applying various technical set-ups. The main problem of in vivo temperature and humidity measurements is a poor spatial and time resolution. Therefore, in vivo measurements are feasible only to a restricted extent, solely providing single temperature values as the complete nose is not entirely accessible. Therefore, data on the overall performance of the nose are only based on one single measurement within each nasal segment. In vivo measurements within the entire nose are not feasible. These serious technical issues concerning in vivo measurements led to a large number of numerical simulation projects in the last few years providing novel information about the complex functions of the nasal airways. In general, numerical simulations merely calculate predictions in a computational model, e.g. a realistic nose model, depending on the setting of the boundary conditions. Therefore, numerical simulations achieve only approximations of a possible real situation. The aim of this review is the synopsis of the technical expertise on the field of in vivo nasal air conditioning, the novel information of numerical simulations and the current state of knowledge on the influence of nasal and sinus surgery on nasal air conditioning.

  10. Mechanically-Excited Sessile Drops

    Science.gov (United States)

    Chang, Chun-Ti; Bostwick, Joshua; Daniel, Susan; Steen, Paul

    2010-11-01

    The volume and contact-line mobility of a sessile drop determine the frequency response of the drop to mechanical excitation. A useful signature of the drop is its response to a sweep of frequency. At particular frequencies the drop exhibits standing wave patterns of different mode numbers and/or azimuthal, spinning motion. We report observations of the spectrum of standing wave patterns and compare to predictions of a linear stability theory. On the side of application, the results suggest how to tune the pinning-unpinning of a sessile drop in order to maximize its translation.

  11. Spindle cell carcinoma of the nasal cavity

    Directory of Open Access Journals (Sweden)

    Mark D DeLacure

    2013-02-01

    Full Text Available Spindle cell carcinoma (SpCC is a unique variant of squamous cell carcinoma (SCC. SpCC confined to the nasal cavity is extremely rare, with only one case having been previously reported. We present a case report of nasal cavity SpCC and review the literature on this rare entity. A 29-year-old male presented with intermittent epistaxis from the left nasal cavity. On physical examination, the patient had an ulcerated mass in the left nasal vestibule and a biopsy showed a proliferation of spindle and epitheliod cells. The patient underwent wide local excision of the mass via a lateral alotomy approach and reconstruction with a composite conchal bowl skin and cartilage graft. Histologically, the mass had dyplastic squamous epithelium and spindle-shaped cells admixed with epitheliod cells. Immunohistochemistry was only positive for pancytokeratin AE1/AE3 and vimentin. Six months after surgery, the patient continues to have no evidence of disease. On literature review, only one previous case of SpCC confined to the nasal cavity was identified. We present a rare case of nasal cavity SpCC. No definite treatment protocol exists for this unique entity, but we believe that this tumor should primarily be treated with aggressive, wide local excision. Adjuvant radiation and/or chemotherapy have also been used anecdotally.

  12. Eosinophilic Angiocentric Fibrosis of the Nasal Septum

    Directory of Open Access Journals (Sweden)

    Yunchuan Li

    2013-01-01

    Full Text Available Background. Eosinophilic angiocentric fibrosis (EAF is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with a slow growing mass at her anterior nasal septum for over eight years. She complained of persistent nasal obstruction, epistaxis, sometimes diffused facial pain, and chronic headache. 3 years ago, the tumor was partially resected for ventilation and a nasal septum perforation was left. Imaging findings indicated soft-tissue thickening of the anterior part of septum and adjacent lateral nasal walls. Pathological examination showed numerous inflammatory cells infiltrates containing eosinophils, fibroinflammatory lesion with a whorled appearance fibrosis which typically surrounded vessels. A diagnosis of eosinophilic angiocentric fibrosis was made. All laboratory tests were unremarkable. Skin prick test was positive. The tumor-like lesion was totally resected. Conclusions. EAF is a rare benign and progressive disorder causing destruction. Combined with radiological imaging of EAF historical findings contribute to the diagnosis. It is important to prevent tumor from recurrence by total resection of the lesion.

  13. Detection of Helicobacter pylori in Nasal Polyps.

    Science.gov (United States)

    Bansal, Divya; Sharma, Sonal; Agarwal, Sarla; Saha, Rumpa; Gupta, Neelima

    2016-09-01

    To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori. H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps. PMID:26830396

  14. NASALIZATION IN BRAZILIAN PORTUGUESE: AN AUTOSEGMENTAL (REVIEW

    Directory of Open Access Journals (Sweden)

    Consuelo de Paiva Godinho COSTA

    2015-06-01

    Full Text Available We propose to make a brief review on nasalization phenomena studies in Portuguese, aiming the phonological process of nasal harmonization that occurs in the variety of Brazilian Portuguese spoken in Vitória da Conquista-BA and region, a phenomenon hitherto not described for any Portuguese dialect. To do so, we consider as fundamental, D’Angelis (2002 analysis, which incorporates relevant concepts presented by Trubetzkoy, from the Prague School, and some points of Camara Jr. propose. We also propose to update the discussion with the approaches along the lines of auto segmental phonology, incorporating some insights of Piggott (1992, discussing with other analyzes for nasalization phenomena in other languages, especially Guarani (language of Tupi-Guarani Linguistic Family, as proposed by Costa (2010, which deals with the phonological processes involving nasality and nasal harmony in Brazilian indigenous languages , in order to verify if the researches on nasality phenomena in other languages can shed some light on the processes that occur in Portuguese.

  15. Controlling charge on levitating drops.

    Science.gov (United States)

    Hilger, Ryan T; Westphall, Michael S; Smith, Lloyd M

    2007-08-01

    Levitation technologies are used in containerless processing of materials, as microscale manipulators and reactors, and in the study of single drops and particles. Presented here is a method for controlling the amount and polarity of charge on a levitating drop. The method uses single-axis acoustic levitation to trap and levitate a single, initially neutral drop with a diameter between 400 microm and 2 mm. This drop is then charged in a controllable manner using discrete packets of charge in the form of charged drops produced by a piezoelectric drop-on-demand dispenser equipped with a charging electrode. The magnitude of the charge on the dispensed drops can be adjusted by varying the voltage applied to the charging electrode. The polarity of the charge on the added drops can be changed allowing removal of charge from the trapped drop (by neutralization) and polarity reversal. The maximum amount of added charge is limited by repulsion of like charges between the drops in the trap. This charging scheme can aid in micromanipulation and the study of charged drops and particles using levitation. PMID:17580951

  16. Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

    Science.gov (United States)

    Zhu, Zheng; Xie, Yanqing; Guan, Weijie; Gao, Yi; Xia, Shu; Shi, Xu

    2016-01-01

    Background The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear. Objective To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR. Methods Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed. Results A total of 25 eligible AR patients enrolled and finished both LTD4 and histamine nasal challenge and completed the questionnaire of RQoLQ. Histamine nasal challenge induced sneezing, increased nasal resistant were correlated with most of the dimensions (general, practical, nasal, eye problems, and quality of sleep, p < 0.05), while LTD4 nasal challenge induced sneeze, increased nasal resistant only correlated with nasal and ocular problems. On the contrary, the severity of the sneeze assessed by TSS4, was not correlated with QoL, while the severity of rhinorrhea, congestion, and nasal pruritus were correlated with nasal and practical problems, and nasal congestion was also correlated with ocular problems (r = 0.60, p = 0.01). Conclusion LTD4 and histamine nasal challenge induced nasal responses were correlated with different clinical symptoms severity and QoL, which can be used as a good diagnosis and evaluation methods for the management of AR.

  17. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving

    Directory of Open Access Journals (Sweden)

    Lorenz, Kai J.

    2014-05-01

    Full Text Available Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures.In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid.After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible.One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used.We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible.

  18. Nasal meatus plasty: a contribution to plastic reconstruction of the nasal valve during midfacial degloving.

    Science.gov (United States)

    Lorenz, Kai J; Maier, Heinz; Wilde, Frank

    2014-01-01

    Midfacial degloving is a proven method for easily accessing the midface, the nasal pyramid, the maxillary and ethmoidal sinuses, the orbits, as well as the anterior skull base. Indications for this method of access mainly include tumour resections in the area of the midface, the septum, the maxillary sinus, the paranasal to the sphenoidal sinus as well as the clivus. In addition, this method of access allows for the exposure of the bony structures of the midface in the event of extensive fractures. In general, this method of access combines an incision in the oral vestibule and circular incisions in the nasal vestibule area in order to release the nasal pyramid. After removing the facial wall of the maxillary sinus, extensive exposure of the surgical site is possible. One disadvantage of this method of access is the difficult reconstruction of the nasal valve area, which often leads to cicatricial stenoses and difficulties with breathing through the nose. Furthermore, wound healing problems and osteoradionecrosis in the area of the lateral margin of the anterior nasal aperture after replantation of the facial wall of the maxillary sinus have been described, because in this area sufficient soft tissue coverage cannot be ensured when a conventional technique is used. We describe a soft tissue flap pedicled in the cranial and caudal directions in the nasal valve area which makes both the reconstruction of the nasal vestibule and sufficient soft tissue coverage of the anterior nasal aperture possible. PMID:26504717

  19. Válvula nasal: anatomia e fisiologia Nasal valve: anatomy and physiology

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Nazareth Nigro

    2009-04-01

    Full Text Available A porção anterior das cavidades nasais, da narina à válvula nasal (VN, é a região de maior resistência nasal ao fluxo aerífero, de suma importância para a fisiologia nasal. Na literatura existem terminologias diferentes para se referir às mesmas estruturas anatômicas e, ainda, o mesmo termo se referindo a estruturas anatômicas diferentes. OBJETIVO: Realizamos este trabalho com o objetivo de revisarmos o funcionamento da VN e definirmos com mais clareza estruturas anatômicas da porção anterior das cavidades nasais, principalmente a região da VN. CONCLUSÃO: Existe controvérsia na literatura quanto à nomenclatura das estruturas da VN. Neste trabalho definimos VN como uma estrutura tridimensional compreendida anteriormente pelo ostium internum e posteriormente pelo isthmus nasi.The anterior portion of the nasal cavities, from the nostril to the nasal valve (NV, is the place of highest nasal resistance to airflow, paramount to nasal physiology. There are different terminologies for the same anatomic structures in the literature. AIM: The aim of this paper was to study the NV function and define clearly the structures of the anterior portion of the nasal cavities, mainly the region of the NV. CONCLUSION: Internum ostium is the anterior segment and isthmus nasi is the posterior segment of the NV region.

  20. Effects of nasal allergen challenge on dynamic viscoelasticity of nasal mucus.

    Science.gov (United States)

    Hattori, M; Majima, Y; Ukai, K; Sakakura, Y

    1993-04-01

    The effects of nasal provocation on the rheologic properties of nasal mucus were investigated in patients with allergic rhinitis provoked by house dust. The elastic modulus (G') and the dynamic viscosity (eta') of nasal mucus were determined by an oscillating sphere magnetic rheometer. Before and after the allergen challenge, G' increased, whereas eta' decreased with increasing oscillatory frequency; these findings indicate that the nasal mucus under these conditions is a non-newtonian fluid and has the cross-linked gel-like nature typical of mucus. Both G' and eta' values after nasal provocation were significantly lower than before. The values of G' and eta' after allergen challenge were in the optimal viscoelasticity range for mucociliary transport. PMID:8476173

  1. Excited Sessile Drops Dance Harmonically

    OpenAIRE

    Chang, Chun-Ti; Daniel, Susan; Steen, Paul H.

    2013-01-01

    In our fluid dynamics video, we demonstrate our method of visualizing and identifying various mode shapes of mechanically oscillated sessile drops. By placing metal mesh under an oscillating drop and projecting light from below, the drop's shape is visualized by the visually deformed mesh pattern seen in the top view. The observed modes are subsequently identified by their number of layers and sectors. An alternative identification associates them with spherical harmonics, as demonstrated in ...

  2. Investigations of levitated helium drops

    Science.gov (United States)

    Whitaker, Dwight Lawrence

    1999-11-01

    We report on the development of two systems capable of levitating drops of liquid helium. Helium drops of ˜20 mum have been levitated with the radiation pressure from two counter-propagating Nd:YAG laser beams. Drops are produced with a submerged piezoelectric transducer, and could be held for up to three minutes in our optical trap. Calculations show that Brillouin and Raman scattering of the laser light in the liquid helium produces a negligible rate of evaporation of the drop. Evaporation caused by the enhanced vapor pressure of the curved drop surfaces appears to be a significant effect limiting the drop lifetimes. Helium drops as large as 2 cm in diameter have been suspended in the earth's gravitational field with a magnetic field. A commercial superconducting solenoid provides the necessary field, field-gradient product required to levitate the drops. Drops are cooled to 0.5 K with a helium-3 refrigerator, and can be held in the trap indefinitely. We have found that when two or more drops are levitated in the same magnetic trap, the drops often remain in a state of apparent contact without coalescing. This effect is a result of the evaporation of liquid from between the two drops, and is found to occur only for normal fluid drops. We can induce shape oscillations in charged, levitated drops with an applied ac electric field. We have measured the resonance frequencies and damping rates for the l = 2 mode of oscillation as function of temperature. We have also developed a theory to describe the small amplitude shape oscillations of a He II drop surrounded by its saturated vapor. In our theory, we have considered two sets of boundary conditions---one where the drop does not evaporate and another in which the liquid and vapor are in thermodynamic equilibrium. We have found that both solutions give a frequency that agrees well with experiment, but that the data for the damping rate agree better with the solution without evaporation.

  3. Nasal commensal Staphylococcus epidermidis counteracts influenza virus

    Science.gov (United States)

    Chen, Hui-Wen; Liu, Pei-Feng; Liu, Yu-Tsueng; Kuo, Sherwin; Zhang, Xing-Quan; Schooley, Robert T.; Rohde, Holger; Gallo, Richard L.; Huang, Chun-Ming

    2016-01-01

    Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition between commensal bacteria and pathogenic species. We demonstrate here that S. epidermidis culture supernatants significantly suppressed the infectivity of various influenza viruses. Using high-performance liquid chromatography together with mass spectrometry, we identified a giant extracellular matrix-binding protein (Embp) as the major component involved in the anti-influenza effect of S. epidermidis. This anti-influenza activity was abrogated when Embp was mutated, confirming that Embp is essential for S. epidermidis activity against viral infection. We also showed that both S. epidermidis bacterial particles and Embp can directly bind to influenza virus. Furthermore, the injection of a recombinant Embp fragment containing a fibronectin-binding domain into embryonated eggs increased the survival rate of virus-infected chicken embryos. For an in vivo challenge study, prior Embp intranasal inoculation in chickens suppressed the viral titres and induced the expression of antiviral cytokines in the nasal tissues. These results suggest that S. epidermidis in the nasal cavity may serve as a defence mechanism against influenza virus infection. PMID:27306590

  4. Detection of Infectious Bovine Rhinotracheitis and Bovine Viral Diarrhea Viruses in the Nasal Epithelial Cells by the Direct Immunofluorescence Technique

    OpenAIRE

    Silim, A.; Elazhary, M. A. S. Y.

    1983-01-01

    Nasal epithelial cells were collected by cotton swabs for the diagnosis in experimental and field cases of infectious bovine rhinotracheitis and field cases of bovine viral diarrhea in calves. A portion of the cells was washed twice in phosphate buffered saline and a 25 µL drop was placed on microscope slides. The cells were dried, fixed and stained according to the direct fluorescent antibody technique. Another portion of the same specimen was inoculated onto primary bovine skin cell culture...

  5. Study of Effect of Resection of Cephalic Portion of Nasal Alar Cartilage on Nasal Tip Rotation

    Directory of Open Access Journals (Sweden)

    N Berjis

    2005-11-01

    Full Text Available Background: One of the most common techniques of nasal tip surgery in rhinoplasty is conservative resection of cephalic portion of nasal alar cartilage; although, there is a controversy about its effectiveness on nasal tip rotation in textbooks and articles. Therefore, in this research, we have studied the effect of conservative resection of cephalic portion of alar cartilage on nasal tip rotation. Methods: 35 patients were selected from the patients who were candidates for septoplasty, after getting their agreement. In surgery we performed conservative resection of cephalic portion of alar cartilage. Nasolabial angles were calculated, using the lateral photographs of the patients before and six monthes after surgery. The means of these angles were analyzed with t-paired test. Results: The means and standard deviations of nasolabial angles before and six months after surgery were 91.49±7.35 and 91.57±7.04, respectively. Calculated P-value was 0.52. Conclusion: There was no meaningful difference between means of nasolabial angles before and six months after surgery (P-value was greater than 0.05. Therefore, in this research we concluded that conservative resection of cephalic portion of alar cartilage has no effect on nasal tip rotation. Key words: nasal alar cartilage, nasolabial angle, nasal tip

  6. Prenatal diagnosis of a nasal glioma.

    Science.gov (United States)

    Grzegorczyk, Véronica; Brasseur-Daudruy, Marie; Labadie, Gérard; Cellier, Cécile; Verspyck, Eric

    2010-10-01

    Nasal glioma is a rare congenital midline malformation composed of heterotopic masses of neuroglial tissue. We report a case of fetal nasal glioma diagnosed by sonography at 22 weeks' gestation as a vascular hypoechoic mass located on the left nasal bone. Fetal MRI excluded an underlying bone defect. At birth, the lesion appeared as a reddish mass. Post natal imaging confirmed the vascularisation within the lesion with an arterial low-flow velocity and a high-resistance spectrum, consistent with a glioma. The child underwent surgery at 5 months and final diagnosis was made on pathological examination. Therefore, a vascular lesion and a clinical aspect mimicking a haemangioma should not be considered sufficient to reach the final diagnosis. PMID:20401478

  7. Paediatric nasal polyps in cystic fibrosis.

    Science.gov (United States)

    Mohd Slim, Mohd Afiq; Dick, David; Trimble, Keith; McKee, Gary

    2016-01-01

    Patients with cystic fibrosis (CF) are at increased risk of nasal polyps. We present the case of a 17-month-old Caucasian patient with CF who presented with hypertelorism causing cycloplegic astigmatism, right-sided mucoid discharge, snoring and noisy breathing. Imaging suggested bilateral mucoceles in the ethmoid sinuses. Intraoperatively, bilateral soft tissue masses were noted, and both posterior choanae were patent. Polypectomy and bilateral mega-antrostomies were performed. Histological examination revealed inflammatory nasal polyposis typical of CF. The role of early functional endoscopic sinus surgery (FESS) in children with CF nasal polyposis remains questionable as the recurrence rate is higher, and no improvement in pulmonary function has been shown. Our case, however, clearly demonstrates the beneficial upper airway symptom relief and normalisation of facial appearance following FESS in a child with this condition. PMID:27329094

  8. Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension.

    Science.gov (United States)

    Faramarzi, Mohammad; Dadgarnia, Mohammad Hossein; Moghimi, Mansour; Sharouny, Hadi; Behniafard, Nasim

    2015-09-01

    Eosinophilic angiocentric fibrosis (EAF) is an extremely rare, chronic, benign, idiopathic disorder that mostly affects the upper respiratory tract, particularly the nasal cavity, and features progressive submucosal perivascular fibrosis. To the best of our knowledge, only seven cases of EAF with orbital involvement have been reported. We report a case of sinonasal EAF with orbital extension that presented with left nasolacrimal duct obstruction. A 35-year-old man presented with left epiphora, proptosis, anterolateral globe displacement and nasal obstruction. Endoscopic sinus examination showed a firm, gritty, creamy, yellow, fibrous, adherent mass of maxillary sinus. Diagnosis was established with histopathological examination of excisional biopsy of the lesion. Although EAF is very rare, it should be considered in the differential diagnosis of lesions of upper airway tract, particularly the nasal cavity. Biopsy is necessary for diagnosis and treatment planning. Resecting of the involved tissues completely is essential for prevention of recurrence. PMID:25601283

  9. Discriminating between Nasal and Mouth Breathing

    CERN Document Server

    Curran, Kevin; Coyle, Damian

    2010-01-01

    The recommendation to change breathing patterns from the mouth to the nose can have a significantly positive impact upon the general well being of the individual. We classify nasal and mouth breathing by using an acoustic sensor and intelligent signal processing techniques. The overall purpose is to investigate the possibility of identifying the differences in patterns between nasal and mouth breathing in order to integrate this information into a decision support system which will form the basis of a patient monitoring and motivational feedback system to recommend the change from mouth to nasal breathing. Our findings show that the breath pattern can be discriminated in certain places of the body both by visual spectrum analysis and with a Back Propagation neural network classifier. The sound file recoded from the sensor placed on the hollow in the neck shows the most promising accuracy which is as high as 90%.

  10. Nanoparticles for nasal delivery of vaccines : monitoring adaptive immune responses

    NARCIS (Netherlands)

    Keijzer, C.

    2013-01-01

    The continuous emergence of new pathogens and growing drug resistance of microorganisms asks for innovative vaccination strategies. An alternative to conventional multiple injection vaccines is the nasal route of vaccine delivery. The immune response induced following nasal antigen delivery depends

  11. Nasal birth trauma: a review of appropriate treatment.

    LENUS (Irish Health Repository)

    Cashman, E C

    2012-02-01

    The aetiology of nasal deformity has frequently included birth trauma. There is no consensus in the literature as to whether nasal surgery, in the form of closed reduction, is indicated in neonates. The majority of studies in the literature that advocate intervention have inadequate followup periods and there is a paucity of evidence for the adverse effects of conservative management. This case highlights the therapeutic dilemma posed by such nasal injuries in the neonate and, to the best of the authors\\' knowledge, at the time of writing, represents the earliest reported case in the literature of nasal deformity in the neonate. The term nasal deformity is used to denote deformity of the nasal pyramid, soft tissue, and septum. Three main aspects of neonatal nasal deformity are addressed including, firstly, if nasal deformity at birth needs to be addressed, secondly, if left unaltered, what the long-term effects are and, finally, if intervention alters the normal course of midfacial development.

  12. Nasal Birth Trauma: A Review of Appropriate Treatment

    Directory of Open Access Journals (Sweden)

    E. C. Cashman

    2010-01-01

    Full Text Available The aetiology of nasal deformity has frequently included birth trauma. There is no consensus in the literature as to whether nasal surgery, in the form of closed reduction, is indicated in neonates. The majority of studies in the literature that advocate intervention have inadequate followup periods and there is a paucity of evidence for the adverse effects of conservative management. This case highlights the therapeutic dilemma posed by such nasal injuries in the neonate and, to the best of the authors' knowledge, at the time of writing, represents the earliest reported case in the literature of nasal deformity in the neonate. The term nasal deformity is used to denote deformity of the nasal pyramid, soft tissue, and septum. Three main aspects of neonatal nasal deformity are addressed including, firstly, if nasal deformity at birth needs to be addressed, secondly, if left unaltered, what the long-term effects are and, finally, if intervention alters the normal course of midfacial development.

  13. Condrossarcoma nasal: relato de caso

    Directory of Open Access Journals (Sweden)

    Pinna Fábio de Rezende

    2003-01-01

    Full Text Available O condrossarcoma é uma neoplasia maligna proveniente de tecido cartilaginoso, cuja incidência em região de cabeça e pescoço é rara. É mais freqüente em pacientes do sexo masculino, entre a terceira e quarta décadas, e na face localiza-se no seio e osso maxilar, sendo raro no septo nasal. Esse relato descreve o caso de uma paciente do sexo feminino, de 13 anos de idade, que apresentava queixa de deformidade facial em região malar direita acompanhada de dores esporádicas. Ao exame físico apresentava um abaulamento de aproximadamente 3 cm de diâmetro em região malar esquerda, não sendo notada nenhuma alteração à rinoscopia anterior. Foram realizadas tomografia computadorizada (TC de seios paranasais, ressonância magnética de face e biópsia da lesão para estudo anatomopatológico, que inicialmente sugeria o diagnóstico de condroma. Após a exérese da massa, a paciente evoluiu com recidiva da lesão em apenas 5 meses. Diante deste fato surpreendente, foi requisitada a revisão da lâmina que evidenciou Condrossarcoma tipo I. Nova cirurgia foi realizada, visando a remoção do tumor, com tratamento radioterápico complementar. Atualmente, a paciente se encontra em acompanhamento ambulatorial, sem queixas álgicas e sem sinas de recidiva. Os condrossarcomas são tumores malignos de crescimento lento, mas localmente agressivos, tendo grande propensão a recidivas. A conduta é preferencialmente cirúrgica, uma vez que são pouco radiossensíveis e a quimioterapia é meramente paliativa. O objetivo deste estudo é apresentar um caso de condrossarcoma em seio maxilar, etmóide, esfenóide e septo, discutindo o quadro clínico, diagnóstico, fatores prognósticos e conduta.

  14. Gas Pressure-Drop Experiment

    Science.gov (United States)

    Luyben, William L.; Tuzla, Kemal

    2010-01-01

    Most chemical engineering undergraduate laboratories have fluid mechanics experiments in which pressure drops through pipes are measured over a range of Reynolds numbers. The standard fluid is liquid water, which is essentially incompressible. Since density is constant, pressure drop does not depend on the pressure in the pipe. In addition, flow…

  15. Breakup of molten aluminum drops

    International Nuclear Information System (INIS)

    To clarify the entrapment of water and the breakup mechanism in molten Al drops, a series of experiments was carried out by pouring molten Al of 10 to 20 g (up to 1,000degC) into a highly subcooled-water pool (room temperature) through the air. A single large-scale water jet, which is capable of penetrating a molten Al drop, was found to appear above the molten Al drop immediately after an air column which the molten drop is dragging from the water surface, is detached. It was observed with a high frequency that a molten Al drop begins swelling first, and is then broken up during falling through the water pool or after hitting the basement. It was also found that the breakup always occurs in the course of solid crust formation, and the molten drop solidified without breakup forms a large cavity inside. Based on the experimental observations, it is concluded that the swelling and the breakup of a molten Al drop should be caused by the water entrapped inside and the hydrogen remaining super-saturated. It is reasonable to consider that an intensive breakup should be caused when some quantity of water is injected into a molten Al drop with a capability that a high-pressure vapor is generated due to a rapid release of latent heat just after brittle cracks occur during swelling. (author)

  16. Primary Nasal Tuberculosis in a 10-Year-Old Girl

    Science.gov (United States)

    Özer, Murat; Özsurekçi, Yasemin; Cengiz, Ali Bülent; Özçelik, Uğur; Yalçın, Ebru; Gököz, Özay

    2016-01-01

    Nasal tuberculosis is a rare clinical entity which mainly presents in elderly people. Nasal tuberculosis has always been considered to be secondary to tuberculosis of the lungs, and in rare instances it is a primary infection, usually when mycobacteria are inhaled. We describe the case of a 10-year-old girl who was successfully treated for primary nasal tuberculosis. This patient is one of the very few children who have been reported to have primary nasal tuberculosis. PMID:27366187

  17. The use of nasal markers for monitoring mallard populations

    OpenAIRE

    Fabião, António; Rodrigues, David; Figueiredo, Maria

    2001-01-01

    We discuss the advantages and limitations of alphanumeric-coded nasal markers used for monitoring resident mallard populations. We tested two designs of nasal saddles, various colours, PVC tape of 2 thicknesses and ribber tape. The rctangular nasal saddle could disturb birds during feeding, so we changed it to a more anatomical design. The use of alphanumeric coded nasal markers was an efficient method for marking mallards in small wetlands with good visibility and for relatively short periods.

  18. Absorption of acetylsalicylic acid from the rat nasal cavity.

    Science.gov (United States)

    Hussain, A A; Iseki, K; Kagoshima, M; Dittert, L W

    1992-04-01

    The fate of salicylate in the plasma of rats was followed after nasal, intravenous, and oral administration of 2.0-mg doses of aspirin. Aspirin was well absorbed following nasal administration of a neutralized, nonirritating solution containing triethanolamine. The rate of absorption was slower than that of other nasally administered drugs, such as propranolol or progesterone. The bioavailability of aspirin following nasal administration was 100%, whereas the oral bioavailability was only 58.8% at the dose studied. PMID:1501071

  19. Intraosseous hemangioma of the nasal septum: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Min Ho; Kim, Eui Jong; Jang, Ji Hye; Lee, Kyung Mi; Choi, Woo Suk; Kim, Sung Wan; Kim, Yoon Hwa [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Hemangioma can arise in the soft tissues and bone of the nasal cavity. However, to the best of our knowledge, there are no prior case reports presenting intraosseous hemangioma of the nasal septum. Intraosseous hemangioma, in addition to a chondroid tumor, should be included in the differential diagnosis of a calcified mass of the nasal cavity. In the present report, we present a case of an intraosseous cavernous hemangioma in the nasal bony septum of a 53-year-old woman.

  20. Endoscopic removal of nasal septum chondrosarcoma in paediatric patient

    OpenAIRE

    Muhammad Nasri Abu Bakar; Rosdi Ramli; Zulkiflee Salahuddin; Irfan Mohamad

    2014-01-01

    Chondrosarcomas of the head and neck are uncommon malignant tumours of non-epithelial origin. They rarely occur in paediatric age group. The treatment is mainly surgical and adjuvant therapy is only reserved to certain cases. We report a boy with progressive history of nasal obstruction and epistaxis. Nasal endoscopy revealed a mass arising from nasal septum. Endoscopic excision of the tumour was successfully done followed by radiotherapy. Endoscopic excision of chondrosarcoma of the nasal...

  1. The NOFLO trial: low-flow nasal prongs therapy in weaning nasal continuous positive airway pressure in preterm infants.

    LENUS (Irish Health Repository)

    O'Donnell, Sinéad M

    2013-07-01

    To determine if low-flow nasal prongs therapy with room air, compared with no treatment, facilitates weaning from nasal continuous positive airway pressure (NCPAP) in very low birth weight (VLBW, birth weight <1500 g) infants.

  2. Staphylococcus aureus and the ecology of the nasal microbiome

    DEFF Research Database (Denmark)

    Liu, Cindy M; Price, Lance B; Hungate, Bruce A;

    2015-01-01

    The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus...

  3. Underlying Phoneme Velar Nasal with Lip Rounding in Hueyapan Nahuatl

    Science.gov (United States)

    Campbell, R. Joe

    1976-01-01

    Reasons are given for the idea that Hueyapan (Morelos) Nahuatl has an underlying velar nasal with lip rounding phoneme which never has the surface reflex of a rounded velar nasal allophone, but occurs phonetically as a velar nasal allophone or a labial dental voiced allophone or disappears. (SCC)

  4. 21 CFR 868.5350 - Nasal oxygen catheter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nasal oxygen catheter. 868.5350 Section 868.5350...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5350 Nasal oxygen catheter. (a) Identification. A nasal oxygen catheter is a device intended to be inserted through a patient's nostril...

  5. 21 CFR 868.5340 - Nasal oxygen cannula.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nasal oxygen cannula. 868.5340 Section 868.5340...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5340 Nasal oxygen cannula. (a) Identification. A nasal oxygen cannula is a two-pronged device used to administer oxygen to a patient...

  6. Instant freezing of impacting wax drops

    Science.gov (United States)

    Ponomarenko, Alexandre; Virot, Emmanuel; Rubinstein, Shmuel

    2015-11-01

    We present the impact of hot liquid drops of wax on surfaces whose temperature is below the solidifying temperature of the drops. During the fall the drops remain mostly liquid, but upon impact, their temperature quickly decreases resulting in the solidification of the drop. Depending on the impact energy, drops size and the temperature difference between the drop and the surface this results in plethora of solid shapes: simple lenses, triangular drops, spherical caps and popped popcorn shapes.

  7. Pool impacts of Leidenfrost drop

    Science.gov (United States)

    Darbois Texier, Baptiste; Maquet, Laurent; Dorbolo, Stephane; Dehandschoewercker, Eline; Pan, Zhao; Truscott, Tadd

    2015-11-01

    This work concerns the impact of a droplet made of a volatile liquid (typically HFE) on a pool of an other liquid (typically silicone oil) which temperature is above the boiling point of the drop. Depending on the properties of the two liquids and the impacting conditions, four different regimes are observed. For low impacting speeds, the droplet bounces on the surface of the bath and finally levitates above it in a Leidenfrost state. Such a regime occurs as soon as the pool temperature exceeds the boiling point of the drop. This observation means that there is no threshold in temperature for a Leidenfrost effect on a liquid surface contrary to the case of a solid substrate. For intermediate impacting velocities, the pinch-off of the surface of the pool entraps the drop in the liquid bulk. The entrapped drop is separated from the pool by a layer of its own vapour in a similar way of antibulles. For increasing impacting speeds, the vapour layer between the drop and the pool does not hold during the pinch-off event. The contact of the drop with the hot liquid provokes a sudden and intense evaporation. At very large impacting speeds, the drop rapidely contacts the pool, spreads and finally induces a hemi-spherical cavity. In the end, these four different regimes are summarized in a Froud-Weber diagram which boundaries are discussed.

  8. Risk factors for nasal malignancies in German men: the South-German Nasal cancer study

    Directory of Open Access Journals (Sweden)

    Greiser Eberhard M

    2012-11-01

    Full Text Available Abstract Background There are few studies of the effects of nasal snuff and environmental factors on the risk of nasal cancer. This study aimed to investigate the impact of using nasal snuff and of other risk factors on the risk of nasal cancer in German men. Methods A population-based case–control study was conducted in the German Federal States of Bavaria and Baden-Württemberg. Tumor registries and ear, nose and throat departments provided access to patients born in 1926 or later. Results Telephone interviews were conducted with 427 cases (mean age 62.1 years and 2.401 population-based controls (mean age 60.8 years. Ever-use of nasal snuff was associated with an odds ratio (OR for nasal cancer of 1.45 (95% confidence interval [CI] 0.88–2.38 in the total study population, whereas OR in smokers was 2.01 (95% CI 1.00-4.02 and in never smokers was 1.10 (95% CI 0.43–2.80. The OR in ever-smokers vs. never-smokers was 1.60 (95% CI 1.24–2.07, with an OR of 1.06 (95% CI 1.05–1.07 per pack-year smoked, and the risk was significantly decreased after quitting smoking. Exposure to hardwood dust for at least 1 year resulted in an OR of 2.33 (95% CI 1.40–3.91 in the total population, which was further increased in never-smokers (OR 4.89, 95% CI 1.92–12.49 in analyses stratified by smoking status. The OR for nasal cancer after exposure to organic solvents for at least 1 year was 1.53 (1.17–2.01. Ever-use of nasal sprays/nasal lavage for at least 1 month rendered an OR of 1.59 (1.04–2.44. The OR after use of insecticides in homes was 1.48 (95% CI 1.04–2.11. Conclusions Smoking and exposure to hardwood dust were confirmed as risk factors for nasal carcinoma. There is evidence that exposure to organic solvents, and in-house use of insecticides could represent novel risk factors. Exposure to asbestos and use of nasal snuff were risk factors in smokers only.

  9. High Flow Nasal Cannulae in preterm infants

    Directory of Open Access Journals (Sweden)

    F. Ciuffini

    2013-06-01

    Full Text Available Despite of improved survival of premature infants, the incidence of long term pulmonary complications, mostly associated with ventilation-induced lung injury, remains high. Non invasive ventilation (NIV is able to reduce the adverse effects of mechanical ventilation. Although nasal continuous positive airway pressure (NCPAP is an effective mode of NIV, traumatic nasal complications and intolerance of the nasal interface are common. Recently high flow nasal cannula (HFNC is emerging as an efficient, better tolerated form of NIV, allowing better access to the baby’s face, which may improve nursing, feeding and bonding. The aim of this review is to discuss the available evidence of effectiveness and safety of HFNC in preterm newborns with respiratory distress syndrome (RDS. It is known that distending pressure generated by HFNC increases with increasing flow rate and decreasing infant size and varies according to the amount of leaks by nose and mouth. The effects of HFNC on lung mechanics, its clinical efficacy and safety are still insufficiently investigated. In conclusion, there is a growing evidence of the feasibility of HFNC as an alternative mode of NIV. However, further larger randomized trials are required, before being able to recommend HFNC in the treatment of moderate respiratory distress of preterm infants.

  10. Tumor relapse present in oncologic nasal repair

    International Nuclear Information System (INIS)

    Introduction: Tumor relapse is one of the more fearsome complications of the oncologic course and also to obscure the life prognosis, causing the loss of many reconstructions and of exhausting the repairing surgical possibilities. The aim of this study was to determine the relapse frequency, the repercussion on the repair and the subsequent medical course of patients operated on malign nasal tumors. Methods: We made a retrospective and descriptive study in 20 patients operated on malign nasal tumors with immediate repair using frontal flap. Patients came from National Institute of Oncology and Radiobiology (NIOR), where they were seen from 2002 and 2007. Results: There were two relapses in 5 patients (25% of total), and the 80% of these were an epidermoid carcinoma. All patients with relapse lost the repaired tissues and received radiotherapy. Only it was possible to repair the defect in one of the patients; two of remained deceased, and were alive, without tumor relapse but without possibilities of repair. Conclusions: Considering the relapse frequency of nasal epidermoid carcinomas and of its repercussions when the Mhos histography technique is not available, it is advisable to delay the nasal repair until will be possible to confirm completely the histology of tumor exeresis. (author)

  11. Measurement of secretion in nasal lavage

    DEFF Research Database (Denmark)

    Bisgaard, H; Krogsgaard, O W; Mygind, N

    1987-01-01

    for repeated use in humans. 4. The nasal lavage technique adopted allowed the return of 99.2% (median value) of the instilled volume. The area irrigated was visualized on a gamma-camera, and was demonstrated to cover an area larger than the area reached by challenge from a pumpspray, i.e. a large part...

  12. Pleomorphic adenoma of the nasal septum

    OpenAIRE

    Saxena, Sunil Kumar; Gopalakrishnan, S

    2003-01-01

    Despite the common occurrence of pleomorphic adenoma of major salivary glands, intranasal pleomorphic adenoma are rare. We present a ease of pleomorphic adenoma of the nasal septum along with a brief review of literature. The histological nature of this lesion in comparison to other salivary gland tumours and the importance of an accurate diagnosis has been stressed.

  13. Fracture of nasal bones: an epidemiologic analysis

    Directory of Open Access Journals (Sweden)

    Fornazieri, Marco Aurélio

    2008-12-01

    Full Text Available Introduction: One of the most common diseases in the otorhinolaryngology emergency room is the nasal bones fracture. The peak of incidence is between 15 and 25 years of age. Generally men are more affected. Objective: To analyze the age, gender and the most frequent causes of nasal fractures evaluated in the otorhinolaryngology service of a tertiary hospital. Method: Retrospective study of records of the patients with nasal fracture diagnosis treated between July 1st, 2003 and July 1st, 2007. Results: 167 patients with nasal bones fracture were included in the study, including 134 men and 33 women. Violence was the most frequent cause, with 55 cases (32.9%, followed by fall from their own height, with 33 cases (19.7%, and motorcycle accident, 14 cases (8.4%. The most common age was between 21 and 39 years (46.1%. Conclusion: Male, age between 21 and 39 years and violence are the most common characteristics found in our service. Motorcycle accidents also play an important role in this affection.

  14. Objective Measures in Aesthetic and Functional Nasal Surgery – Perspectives on Nasal Form and Function

    OpenAIRE

    Pawar, Sachin S.; Garcia, Guilherme J. M.; Kimbell, Julia S.; Rhee, John S.

    2010-01-01

    The outcomes of aesthetic and functional nasal surgery are difficult to assess objectively due to the intricate balance between nasal form and function. Despite historical emphasis on patient-reported subjective measures, objective measures are gaining importance in both research and the current outcomes-driven healthcare environment. Objective measures presently available have several shortcomings which limit their routine clinical use. In particular, the low correlation between objective an...

  15. Coblation nasal septal swell body reduction for treatment of nasal obstruction: a preliminary report.

    Science.gov (United States)

    Kim, So Jeong; Kim, Hee Tae; Park, Yun Hwi; Kim, Ju Yeon; Bae, Jung Ho

    2016-09-01

    In this paper, we present the results of coblation nasal septal swell body (NSB) reduction for the treatment of nasal obstruction in patients with abnormally thickened NSB. The study design was a retrospective clinical series conducted at a single tertiary medical center. Eight patients underwent coblation NSB reduction. Pre-operative and post-operative nasal functions were evaluated by acoustic rhinometry and subjective symptom scales. We also analyzed pre-operative CT scan images and nasal endoscopic findings. The mean maximal NSB width was 16.4 ± 2.2 mm on pre-operative coronal CT scan images. The mean visual analog scale score for nasal obstruction was decreased from preoperative 7.63 ± 0.99 points to 3.88 ± 0.92 points (postoperative 3 months), 4.16 ± 0.78 points (postoperative 6 months), and 4.63 ± 0.69 points (postoperative 1 year). Six out of the eight patients were satisfied with the clinical outcome at 1 year after the procedure. To the best of our knowledge, coblation NSB reduction has not yet been reported in the medical literature. Our results show that it can be an effective treatment modality for nasal valve narrowing in patients with abnormally thickened NSB. PMID:26912145

  16. Coblation nasal septal swell body reduction for treatment of nasal obstruction: a preliminary report.

    Science.gov (United States)

    Kim, So Jeong; Kim, Hee Tae; Park, Yun Hwi; Kim, Ju Yeon; Bae, Jung Ho

    2016-09-01

    In this paper, we present the results of coblation nasal septal swell body (NSB) reduction for the treatment of nasal obstruction in patients with abnormally thickened NSB. The study design was a retrospective clinical series conducted at a single tertiary medical center. Eight patients underwent coblation NSB reduction. Pre-operative and post-operative nasal functions were evaluated by acoustic rhinometry and subjective symptom scales. We also analyzed pre-operative CT scan images and nasal endoscopic findings. The mean maximal NSB width was 16.4 ± 2.2 mm on pre-operative coronal CT scan images. The mean visual analog scale score for nasal obstruction was decreased from preoperative 7.63 ± 0.99 points to 3.88 ± 0.92 points (postoperative 3 months), 4.16 ± 0.78 points (postoperative 6 months), and 4.63 ± 0.69 points (postoperative 1 year). Six out of the eight patients were satisfied with the clinical outcome at 1 year after the procedure. To the best of our knowledge, coblation NSB reduction has not yet been reported in the medical literature. Our results show that it can be an effective treatment modality for nasal valve narrowing in patients with abnormally thickened NSB.

  17. Elevation of soluble interleukin-2 receptor levels in nasal allergy

    OpenAIRE

    Hisamatsu, K.; T. Ganbo; Nakazawa, T; S. Horiguchi; Shimomura, S; Murakami, Y.

    1995-01-01

    To investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients (n = 26) compared with those of healthy subjects (n = 9). IL-2R-positive (CD25+) cells were observed in the crust formed in an allergic nasal mucosa. ...

  18. Nasal surgery in patients with systemic disorders

    Directory of Open Access Journals (Sweden)

    Sachse, Florian

    2010-01-01

    Full Text Available Multisystemic disorders represent a heterogenous group of diseases which can primarily manifest at the nose and paranasal sinuses as limited disease or secondarily as part of systemic involvement. Rhinologists therefore play an important role in the diagnostic but also therapeutic process. Although therapy of multisystemic disorders is primary systemic, additional rhinosurgery may become necessary. The spectrum of procedures consists of sinus surgery, surgery of the orbit and lacrimal duct, septorhinoplasty and closure of nasal septal perforation. Since the prevalence of most systemic diseases is very rare, recommendations are based on the analysis of single case reports and case series with a limited number of patients only. Although data is still limited, experiences published so far have shown that autologous cartilage or bone grafts can be used in nasal reconstruction of deformities caused by tuberculosis, leprosy, Wegener’s granulomatosis, sarcoidosis and relapsing polychondritis. Experiences gained from these diseases support the concept that well-established techniques of septorhinoplasty can be used in systemic diseases as well. However, a state of remission is an essential condition before considering any rhinosurgery in these patients. Even under these circumstances revision surgery has to be expected more frequently compared to the typical collective of patients undergoing septorhinoplasty. In addition, experiences gained from saddle nose reconstruction may in part be of value for the treatment of nasal septal perforations since implantation of cartilage grafts often represents an essential step in multilayer techniques of closure of nasal septal perforations. Aside from the treatment of orbital complications sinus surgery has been proven beneficial in reducing nasal symptoms and increasing quality of life in patients refractory to systemic treatment.

  19. RECENT TECHNIQUES IN NASAL DRUG DELIVERY: A REVIEW

    Directory of Open Access Journals (Sweden)

    Parmar Harshad

    2010-09-01

    Full Text Available Nasal drug administration has been used as an alternative route for the systemic availability of drugs restricted to intravenous administration. This is due to the large surface area, porous endothelial membrane, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including numerous compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in rapid systemic drug absorption. Approaches are discussed here for increasing the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. The article highlights the importance and advantages of the nasal drug delivery systems stressed upon bioadhesive properties. Bioadhesive, or more appropriately, mucoadhesive systems have been prepared for both oral and peroral administration in the past. The nasal mucosa presents an ideal site for bioadhesive drug delivery systems. In this review we discuss the effects of microspheres and other bioadhesive drug delivery systems on nasal drug absorption. Drug delivery systems, such as microspheres, liposomes and gels have been demonstrated to have good bioadhesive characteristics which swell easily when in contact with the nasal mucosa. These drug delivery systems have the ability to control the rate of drug clearance from the nasal cavity as well as protect the drug from enzymatic degradation in nasal secretions.

  20. Drop spreading with random viscosity

    CERN Document Server

    Xu, Feng

    2016-01-01

    We examine theoretically the spreading of a viscous liquid drop over a thin film of uniform thickness, assuming the liquid's viscosity is regulated by the concentration of a solute that is carried passively by the spreading flow. The solute is assumed to be initially heterogeneous, having a spatial distribution with prescribed statistical features. To examine how this variability influences the drop's motion, we investigate spreading in a planar geometry using lubrication theory, combining numerical simulations with asymptotic analysis. We assume diffusion is sufficient to suppress solute concentration gradients across but not along the film. The solute field beneath the bulk of the drop is stretched by the spreading flow, such that the initial solute concentration immediately behind the drop's effective contact lines has a long-lived influence on the spreading rate. Over long periods, solute swept up from the precursor film accumulates in a short region behind the contact line, allowing patches of elevated v...

  1. Free Auricular Composite Graft for Acquired Nasal Stenosis

    Science.gov (United States)

    Riley, Charles A.; Lawlor, Claire M.; Gray, Mingyang Liu; Graham, H. Devon

    2016-01-01

    Background: Acquired nasal stenosis poses a reconstructive challenge for the facial plastic surgeon. Many surgical options are available, ranging from primary closure to skin grafts to free flap reconstruction for complex defects. The free auricular composite graft is a single-stage procedure that can be used to repair nasal vestibular stenosis causing nasal obstruction. Case Report: We present the case of a patient with acquired nasal stenosis as a result of prolonged nasal tampon placement secondary to severe epistaxis and subsequent nasal vestibular infection. Repair via auricular composite graft was successful, and we provide a thorough explanation of graft design and operative technique. Conclusion: Free auricular composite grafts can produce desirable functional and aesthetic outcomes and should be considered in patients presenting with acquired nasal stenosis. PMID:27303225

  2. Evaluation of the nasal shape after orthognathic surgery

    Directory of Open Access Journals (Sweden)

    Wagner Ranier Maciel Dantas

    2015-02-01

    Full Text Available Introduction: Patients with dentofacial deformities may benefit from orthognathic surgery in the maxilla. Maxillary osteotomy may include procedures in the bone, cartilaginous, and soft tissues of the nose, leading to shape alterations. Objective: To evaluate the anatomic alterations of the nasal region in patients undergoing a Le Fort I osteotomy for advancement or superior impaction. Methods: This is a clinical prospective study. Twenty-one patients were evaluated during the preand postoperative periods. The positioning of the nasal tip and the modification of the nasal base were evaluated. Results: The results showed that the nasal tip was superiorly positioned in 85% of the cases, advanced in 80%, rotated in 80%, and there was a wide nasal base in 95%, resulting in esthetic improvement. Conclusions: Surgeries of maxillary advancement and superior reposition tend to cause elevation and advancement of the nasal tip, as well as enlargement of the nasal base.

  3. The effect of nasalization on /a/ vowel formants before and after nasal consonant in 4-9-year old normal Persian speaking children

    OpenAIRE

    Kowsar Baghban; Farhad Torabinezhad; Negin Moradi; Akbar Biglarian

    2014-01-01

    Background and Aim : Nasalization of a vowel refers to the addition of nasal resonance to the vocal tract transfer function. Also, vowel nasalization occurs because of coarticulation. Coupling of the nasal resonating space to the oropharyngeal cavity alters the vocal tract formants in complex ways. The purpose of this study was to investigate the effect of nasalization on /a/ vowel formants in before and after nasal consonant.Methods: In current cross-sectional study, voice samples of 60 norm...

  4. Electrostatic Liquid-Drop-Levitation System

    Science.gov (United States)

    Rhim, Won Kyu; Chung, San Kun; Hyson, Michael T.; Elleman, Daniel D.

    1988-01-01

    Electrostatic levitator has levitated drops of liquid up to 4 mm in diameter while maintaining spherical drop shapes. Stable levitation of spherical drops valuable in experiments involving super-cooling, solidification, and crystal growth.

  5. Deposition of ultrafine aerosols in F344/N rat nasal casts

    International Nuclear Information System (INIS)

    Determination of regional respiratory deposition of inhaled aerosols is critical for evaluation of the health effects of air pollutants. Information on deposition of larger particles (> 0.02 μm) in the nasal passages of laboratory animals is available; the deposition fraction increases with increasing particle size. Little information on ultrafine particles less than 0.2 μm is available. Molds (models) were prepared from replica casts of the nasal passages of F344/N rats, using clear casting plastic. Total deposition of ultrafine aerosols in these casts was then determined using a unidirectional flow system. Measured pressure drops in the casts were a function of flow rate to the power of 1.4-1.6, indicating that the flow through the nasal passage was not laminar. Deposition data were obtained from these casts, using monodisperse sodium chloride aerosols with particle size ranging from 0.2 to 0.005 μm, at inspiratory and expiratory flow rates of 200 to 600 cc/min. Similar deposition data were obtained for the three casts studied. The deposition efficiency was greatest for the smallest particles, and decreased with increasing particle size and flow rate, indicating that diffusion was the dominant mechanism for deposition. At an inspiratory flow rate of 400 cc/min, which is comparable to a respiratory minute volume of 200 cc/min for mature male F344/N rats, deposition efficiencies reached 40 and 70% for 0.01 and 0.005 μm particles, respectively. Turbulent diffusion was considered to be the dominant mechanism for deposition of ultrafine particles in the nasal passage. This information is important for understanding the toxicity and carcinogenicity of submicrometer particles, including diesel soot, radon progeny and vapors. (author)

  6. Adenoma pleomórfico de septo nasal: relato de caso Pleomorphic adenoma of the nasal septum: a case report

    Directory of Open Access Journals (Sweden)

    Mauren P. Rocha

    2004-06-01

    Full Text Available As neoplasias nasais são bastante raras. Os tumores mais observados na cavidade nasal são papilomas epiteliais, angiomas, carcinoma de células transicionais, carcinoma pavimentoso e adenocarcinoma. O adenoma pleomórfico pertence ao grupo de tumores que aparecem com menor freqüência na fossa nasal, e é o tumor benigno glandular mais comum originado na cabeça e pescoço. A apresentação clínica típica dos pacientes com adenoma pleomórfico do septo nasal é de obstrução nasal unilateral, epistaxe e massa indolor na cavidade nasal. Em vista da raridade da apresentação clínica do adenoma pleomórfico nesta localização, os autores descrevem um caso de adenoma pleomórfico nasal em um paciente do sexo masculino, com 69 anos de idade, onde relatam os achados clínicos, critérios diagnósticos, tratamento, prognóstico e revisão da literatura.Nasal tumours are very rare. The neoplasms most frequently seen in the nasal cavity are epithelial papillomas, angiomas, transitional cells carcinoma, pavement carcinoma and adenocarcinoma. The pleomorphic adenoma belongs to the group of tumours less commonly observed in the nasal cavity, and is the most common head and neck benign glandular tumour. The typical clinical presentation of the nasal pleomorphic adenoma is of unilateral nasal obstruction, epistaxis and a painless mass in the nasal cavity. The authors reported an adenoma pleomorphic case that highlights itself by its unusual nasal presentation in the nasal septum of a 45-year-old male patient who was submitted to surgical treatment, and discuss the clinical findings, diagnostic criteria, treatment, prognosis and literature review.

  7. Differential Diagnosis of Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    London, Nyall R; Reh, Douglas D

    2016-01-01

    Nasal polyps are semi-translucent mucosal outgrowths of the paranasal sinuses which typically arise in the setting of chronic rhinosinusitis (CRS). Nasal polyps are also associated with asthma, aspirin sensitivity, cystic fibrosis and allergic fungal rhinosinusitis (AFS). The majority of nasal polyps are bilateral and characterized by tissue edema and eosinophil infiltration. Patients with nasal polyps often present with complaints including nasal obstruction, congestion, rhinorrhea or altered sense of smell. The differential diagnosis ranges from benign masses such as schneiderian papilloma, antrochoanal polyp, angiofibroma and encephalocele to malignant neoplasms such as squamous cell carcinoma (SCC), esthesioneuroblastoma, nasal lymphoma and rhabdomyosarcoma. These lesions may have a similar appearance as nasal polyps and particular attention to an alternative diagnosis for nasal polyps should be entertained if the mass is unilateral or congenital in nature. Workup for patients with a unilateral mass should include radiographic imaging, possible biopsy and careful follow-up when appropriate. Here, we review the disease etiology of nasal polyps and describe the approach to the patient with nasal polyps with emphasis on differential diagnosis and workup. PMID:27466841

  8. External nasal dilators: definition, background, and current uses

    Directory of Open Access Journals (Sweden)

    Dinardi RR

    2014-11-01

    Full Text Available Ricardo Reis Dinardi, Cláudia Ribeiro de Andrade, Cássio da Cunha Ibiapina Department of Pediatrics, Pediatric Pulmonology Unit, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Abstract: Our goal was to revise the literature about external nasal dilators (ENDs as to their definition, history, and current uses. We reviewed journals in the PubMed and MEDLINE databases. The current uses hereby presented and discussed are physical exercise, nasal congestion and sleep, snoring, pregnancy, cancer, and healthy individuals. Numerous studies have shown that ENDs increase the cross-sectional area of the nasal valve, reducing nasal resistance and transnasal inspiratory pressure and stabilizing the lateral nasal vestibule, avoiding its collapse during final inspiration. These effects also facilitate breathing and are beneficial to patients with nasal obstruction. Furthermore, END use is simple, noninvasive, painless, affordable, and bears minimum risk to the user. Most studies have limited sample size and are mainly focused on physical exercise. In conclusion, ENDs seem useful, so further studies involving potential effects on the performance of physical tests and improvements in sleep quality are necessary, especially in children and teenagers. Keywords: external nasal dilator, nasal valve, nasal congestion, nasal resistance

  9. Fundus imaging with a nasal endoscope

    Directory of Open Access Journals (Sweden)

    P Mahesh Shanmugam

    2015-01-01

    Full Text Available Wide field fundus imaging is needed to diagnose, treat, and follow-up patients with retinal pathology. This is more applicable for pediatric patients as repeated evaluation is a challenge. The presently available imaging machines though provide high definition images, but carry the obvious disadvantages of either being costly or bulky or sometimes both, which limits its usage only to large centers. We hereby report a technique of fundus imaging using a nasal endoscope coupled with viscoelastic. A regular nasal endoscope with viscoelastic coupling was placed on the cornea to image the fundus of infants under general anesthesia. Wide angle fundus images of various fundus pathologies in infants could be obtained easily with readily available instruments and without the much financial investment for the institutes.

  10. SEPTOPLASTY WITH AND WITHOUT NASAL PACKING: A COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Mitta

    2016-05-01

    Full Text Available Septoplasty is one of the most commonly performed surgeries in rhinology to relieve nasal obstruction of patients with distortion in the midline cartilage or septum of the nose to relieve nasal obstruction of patient and findings consistent with nasal endoscopy. The anterior nasal packing routinely done following septoplasty is usually conventional and not evidence based. The purpose of nasal packing is to obtain haemostasis, enhance opposition of septal flaps, avoid septal haematoma formation, close the dead space, avoid synechiae formation, provide support to septal cartilage and prevent its displacement. OBJECTIVE This study intends to evaluate the effects of nasal packing on surgical success and related complications in septoplasty. MATERIALS AND METHODS The present clinical prospective and randomised study was carried out on patients attending Otorhinolaryngology Department of Santhiram Medical College & General Hospital between March 2012 and March 2015. Patients undergoing septoplasty were randomised either to receive anterior nasal packing or to not receive nasal packing postoperatively. RESULTS Levels of pain experienced by patients with nasal packing postoperatively during the initial 24 hours postoperatively and during the removal of the pack were significantly more. Post-operative headache, epiphora, swallowing discomfort and sleep disturbance were more in patients with nasal packing and statistically (p.05. Septal haematoma, adhesions and local infections in both groups were statistically insignificant (p>.05. CONCLUSION Septoplasty enhances the standard of living of patients with septal deviation and nasal obstruction. Our study results suggest that nasal packing after septoplasty is not obligatory. Nasal packing causes considerably more pain and complications, and it should be reserved only for those who have bleeding predisposition.

  11. Static Magnetowetting of Ferrofluid Drops.

    Science.gov (United States)

    Rigoni, Carlo; Pierno, Matteo; Mistura, Giampaolo; Talbot, Delphine; Massart, René; Bacri, Jean-Claude; Abou-Hassan, Ali

    2016-08-01

    We report results of a comprehensive study of the wetting properties of sessile drops of ferrofluid water solutions at various concentrations deposited on flat substrates and subjected to the action of permanent magnets of different sizes and strengths. The amplitude and the gradient of the magnetic field experienced by the ferrofluid are changed by varying the magnets and their distance to the surface. Magnetic forces up to 100 times the gravitational one and magnetic gradients up to 1 T/cm are achieved. A rich phenomenology is observed, ranging from flattened drops caused by the magnetic attraction to drops extended normally to the substrate because of the normal traction of the magnetic field. We find that the former effect can be conveniently described in terms of an effective Bond number that compares the effective drop attraction with the capillary force, whereas the drop's vertical elongation is effectively expressed by a dimensionless number S, which compares the pressure jump at the ferrofluid interface because of the magnetization with the capillary pressure. PMID:27385506

  12. BLIND NASAL INTUBATION IN CRANIOROFACIAL TRAUMA

    Directory of Open Access Journals (Sweden)

    K.R.DavidThakaran

    2013-09-01

    Full Text Available Restricted mouth opening presents one of the greatest challenges to the anesthetist for endotracheal intubation and ventilation. Awake blind nasal intubation has been one of the finest and favored techniques for intubation in previous decades for restricted mouth opening patients. A coordinated team approach, monitoring and adequate counseling of the patient is mandatory for the airway management to carry out a safe surgical procedure

  13. Reconstructing the extended nasal tip defect.

    Science.gov (United States)

    Mobley, Steven

    2013-10-01

    Reconstruction of large facial defects requires surgical skill, an understanding of engineering principles, an artistic eye, and patience to design the most elegant solution for each patient. Extended nasal tip defects, which may involve additional facial subunits, require even more thoughtful analysis and planning. Reconstructive surgeons need to be aware of the pros and cons of various options for flaps, the use of a delay stage, and sequencing and scheduling of staged operations to achieve an optimal outcome. PMID:24037937

  14. Brain-Targeted Nasal Clonazepam Microspheres

    OpenAIRE

    Shaji J; Poddar A; Iyer S

    2009-01-01

    Gelatin-chitosan mucoadhesive microspheres of clonazepam were prepared using the emulsion cross linking method. Mirospheres were evaluated using the in vitro and ex vivo drug release patterns. In vivo CNS drug distribution studies were carried out in rats by administering the clonazepam microspheres intra-nasally and clonazepam solution intravenously. From the drug levels in plasma and CSF, drug targeting index and drug targeting efficiency were calculated. Results obtained indicated that int...

  15. Status of glutathione in nasal epithelium

    International Nuclear Information System (INIS)

    During inhalation exposure to air-born toxicants, the nasal epithelium may be subjected to local toxicity. Since glutathione (GSH) is often involved in xenobiotic metabolism, GSH status in these tissues has been examined. GSH content and apparent first-order rate constants for GSH content and apparent first-order rate constants for GSH turnover and synthesis were determined for respiratory epithelium covering the anterior ventral septum, olfactory epithelium covering the dorsal posterior septum, olfactory epithelium covering the dorsal meatus from male Fischer rats. The three tissues had similar concentrations of GSH (approximately 3-3.4 umol/g tissue) as determined by the Ellman's assay or by HPLC equipped with an electrochemical detector. Animals were administered [35S]Cysteine (Cys) by tail vein injection and rate constants were estimated, after incorporation of Cys into tissue GSH pools, by the decrease in GSH specific activity 1-102 hr after administration. Total [35S]GSH was analyzed by HPLC with a flow-through radioactivity detector. The three nasal epithelial tissues had similar apparent biphasic rates of GSH turnover, with rapid-phase half-lives of less than 10 hr and slow-phase half-lives of approximately 30 hr. The high GSH concentrations and the apparent rapid GSH turnover may facilitate the GSH-mediated detoxification within nasal tissue

  16. Surgical Nasal Implants: Indications and Risks.

    Science.gov (United States)

    Genther, Dane J; Papel, Ira D

    2016-10-01

    Rhinoplasty often requires the use of grafting material, and the goal of the specific graft dictates the ideal characteristics of the material to be used. An ideal material would be biologically inert, resistant to infection, noncarcinogenic, nondegradable, widely available, cost-effective, readily modifiable, and easily removable, have compatible biomechanical characteristics, retain physical properties over time, and not migrate. Unfortunately, no material currently in existence meets all of these criteria. In modern rhinoplasty, autologous grafts are the gold standard against which all other nasal implants are measured and offer the safest long-term results for most patients. They are easily manipulated, have inherent stability and biomechanical characteristics similar to the native nasal framework, and confer minimal risk of complications. Modern homologous and alloplastic materials have gained considerable support in recent years because they are readily available in endless quantity, do not require a second surgical site for harvest, and are generally considered safe if most circumstances, but they confer additional risk and have biomechanical characteristics different from that of the native nasal framework. To address some of these issues, we provide a contemporary review of autologous, homologous, and alloplastic materials commonly used in rhinoplasty surgery. PMID:27680520

  17. [Language tests for the examination of nasal resonance].

    Science.gov (United States)

    Gasiorek, J; Pruszewicz, A; Obrebowski, A

    1996-01-01

    A set of 7 word tests with different number of nasal phonemes was prepared. These tests are adjusted to technical possibilities of nasal resonance examination by means of own construction apparatus. The VII-th test consisting only oral speech sounds appeared to be most important for estimating physiological nasal resonance characteristic for the Polish language and gave individual timbre of the voice. For Polish language these resonance rate is 15.2%. It is useful as reference data to evaluate patients with pathological nasal resonance. The VII-th test together with the V-th one which contain 6.3% of nasal consonants, and the VI-th with 33.3% of them were used for detailed evaluation of nasal resonance.

  18. Web-based analysis of nasal sound spectra.

    Science.gov (United States)

    Seren, Erdal

    2005-10-01

    The spectral analysis of the nasal sound is an indicator of the nasal airflow pattern. We investigated a new technique for nasal sound analysis via Internet. This study includes 27 patients and 22 healthy people. Patients were treated by septoplasty operation for septal deviation. Postoperation 10(th) day, this technique was applied to follow nasal airflow course. The patients recorded the nasal sound by microphone into the computer as a .wav file and sent us via internet, all those records were evaluated by us. The results were sent back to themselves. The 11 patients who had nasal obstruction symptoms (group A) were called to the hospital to check. In the nasal sound analyses e-mails of those patients, the sound intensity was at high frequencies (2-4 kHz, 4-6 kHz) above 30 dB, but low (500-1000 Hz) and medium frequencies (1-2 kHz), are below then 10 dB. In the patients without nasal obstruction symptom (group B), the sound intensity was at high frequencies below 10 dB, but low and medium frequencies are above 20 dB. There was a statistically significant difference in sound intensity between group A and group B. In the endoscopical examination of those obstructions, which decreases the nasal airway, crusting formation in the nasal cavity was found. Web-based nasal sound analysis is an important method to follow the postoperative course and the nasal airflow evaluation. The new method will save time and money, avoiding a return visit to the hospital unnecessarily.

  19. A Comparative Study of Septoplasty With or Without Nasal Packing

    OpenAIRE

    Walikar, Basavaraj N.; Rashinkar, S. M.; Watwe, M. V.; Fathima, Anees; Kakkeri, Ashfak

    2011-01-01

    This study was conducted to compare the outcome of septoplasty with or without Nasal packing. The study subjects were randomly allocated into two groups. There was significant reduction in frequency of post operative pain, headache, discomfort and duration of hospital stay in patients who have undergone septoplasty without nasal packing. However there was no difference in post operative bleeding and septal perforation between two groups. Therefore after Septoplasty without nasal packing is pr...

  20. Patient experience with mupirocin or povidone-iodine nasal decolonization.

    Science.gov (United States)

    Maslow, Jed; Hutzler, Lorraine; Cuff, Germaine; Rosenberg, Andrew; Phillips, Michael; Bosco, Joseph

    2014-06-01

    Led by the federal government, the payers of health care are enacting policies designed to base provider reimbursement on the quality of care they render. This study evaluated and compared patient experiences and satisfaction with nasal decolonization with either nasal povidone-iodine (PI) or nasal mupirocin ointment (MO). A total of 1903 patients were randomized to undergo preoperative nasal decolonization with either nasal MO or PI solution. All randomized patients were also given 2% chlorhexidine gluconate topical wipes. Patients were interviewed prior to discharge to assess adverse events and patient experience with their assigned preoperative antiseptic protocol. Of the 1903 randomized patients, 1679 (88.1%) were interviewed prior to discharge. Of patients receiving PI, 3.4% reported an unpleasant or very unpleasant experience, compared with 38.8% of those using nasal MO (P.05). Being recruited as an active participant in surgical site infection prevention was a positive experience for 87.2% of MO patients and 86.3% of PI patients (P=.652). Those assigned to receive PI solution preoperatively reported significantly fewer adverse events than the nasal MO group (P<.01). Preoperative nasal decolonization with either nasal PI or MO was considered somewhat or very helpful by more than two-thirds of patients. PMID:24972440

  1. ``Quantum'' interference with bouncing drops

    Science.gov (United States)

    Bohr, Tomas; Andersen, Anders; Madsen, Jacob; Reichelt, Christian; Lautrup, Benny; Ellegaard, Clive; Levinsen, Mogens

    2013-11-01

    In a series of recent papers (most recently) Yves Couder and collaborators have explored the dynamics of walking drops on the surface of a vibrated bath of silicon oil and have demonstrated a close analogy to quantum phenomena. The bouncing drop together with the surface wave that it excites seems to be very similar to the pilot wave envisaged by de Broglie for quantum particles. In particular, have studied a double slit experiment with walking drops, where an interference pattern identical to the quantum version is found even though it is possible to follow the orbits of the drops and unambigously determine which slit it goes through, something which in quantum mechanics would be ruled out by the Heisenberg uncertainly relations. We have repeated the experiment and present a somewhat more complicated picture. Theoretically, we study a Schrödinger equation with a source term originating from a localised ``particle'' being simultaneously guided by the wave. We present simple solutions to such a field theory and discuss the fundamental difficulties met by such a theory in order to comply with quantum mechanics.

  2. Fluid flow in drying drops

    NARCIS (Netherlands)

    Gelderblom, H.

    2013-01-01

    When a suspension drop evaporates, it leaves behind a drying stain. Examples of these drying stains encountered in daily life are coffee or tea stains on a table top, mineral rings on glassware that comes out of the dishwasher, or the salt deposits on the streets in winter. Drying stains are also pr

  3. Evaporating Drops of Alkane Mixtures

    CERN Document Server

    Gu'ena, G; Poulard, C; Cazabat, Anne-Marie; Gu\\'{e}na, Geoffroy; Poulard, Christophe

    2005-01-01

    Alkane mixtures are model systems where the influence of surface tension gradients during the spreading and the evaporation of wetting drops can be easily studied. The surface tension gradients are mainly induced by concentration gradients, mass diffusion being a stabilising process. Depending on the relative concentration of the mixture, a rich pattern of behaviours is obtained.

  4. A comparison of beclomethasone dipropionate aqueous nasal spray and beclomethasone dipropionate pressurized nasal spray in the management of seasonal rhinitis.

    OpenAIRE

    Dunn, A. M.; Wilson, R.S.; Baggott, P. J.

    1984-01-01

    Forty patients with seasonal rhinitis and a proven sensitivity to pollens were studied for 2 weeks during the pollen season of 1982. The study was carried out according to a double-blind, double-dummy design. All patients received 100 micrograms beclomethasone dipropionate (BDP) into each nostril twice daily (400 micrograms/day) on a randomized basis, from either the aqueous nasal spray or the pressurized nasal spray (Beconase Nasal Spray). Analysis of patients' symptom scores, additional sym...

  5. Randomized trial of prongs or mask for nasal continuous positive airway pressure in preterm infants.

    LENUS (Irish Health Repository)

    Kieran, Emily A

    2012-11-01

    To determine whether nasal continuous positive airway pressure (NCPAP) given with nasal prongs compared with nasal mask reduces the rate of intubation and mechanical ventilation in preterm infants within 72 hours of starting therapy.

  6. Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients

    NARCIS (Netherlands)

    D. L. Holton; L. E. Nicolle; D. Diley; K. Bernstein

    1991-01-01

    textabstractTopical 2% mupirocin ointment eradicated chronic Staphylococcus aureus nasal carriage immediately post-therapy in 17 (77%) of 22 haemodialysis patients. Mean time to recurrence was 3.8 weeks. Similar pre-therapy and post-therapy phage types occurred in 12 (71%) of 17 patients. Staphyloco

  7. Chronic urticaria treated with soft nasal filters

    Directory of Open Access Journals (Sweden)

    Pasricha J

    1995-01-01

    Full Text Available A 22-year-old boy having two attacks of urticaria per day for the last 5 years and intermittent attacks of sneezing and rhinorrhoea, and without any clues to the causative agent in spite of a detailed history and follow up, showed almost complete relief on wearing an ordinary cloth mask for 3 days. He was subsequently trained to use the soft nasal filters and obtained almost 80% relief in urticaria and complete relief in rhinitis during the next 1 year. Wearing the mask for 2 days again led to complete relief and further training in the proper use of the filters was helpful.

  8. [Nasal Highflow - Treatment option in severe hypoxaemia?].

    Science.gov (United States)

    Bräunlich, Jens; Wirtz, Hubert

    2015-12-01

    Nasal High Flow (NHF) provides a warmed and humidified air stream. In pediatrics, this method is already in widespread use and is increasingly replacing the CPAP. New studies show success in treating adults. Currently the acute hypoxemic insufficiency cause of pneumoniae is a secured area of use. NHF is not inferior in comparison to other oxygen delivery systems. At this juncture effectiveness of this easy to use method is not clear. Preliminary reports describe an improvement in ventilation by the NHF. Here, a wash-out of the airways and improved alveolar ventilation seem to be the main operating principles. PMID:26625231

  9. Drop impact on a fiber

    Science.gov (United States)

    Kim, Sung-Gil; Kim, Wonjung

    2016-04-01

    We present the results of a combined experimental and theoretical investigation of drop impact on a thin fiber. Using high-speed videography, we analyze the dynamics of droplet collision with a fiber. Based on the systematic experiments, we identify three outcomes of collision: capturing, single drop falling, and splitting. The outcomes are presented in a regime map, where the regime boundaries are explained through a scale analysis of forces. We also measure the liquid retention on the fiber after the droplet impact. By considering a liquid film on the fiber, we develop a mechanical model that predicts the residual water mass. Our model reveals that the residual mass depends critically on the fiber thickness and less on the impact speed. Our study can be extended to predicting the remaining droplet, critical problems in air filtration, water collection, and fiber coating.

  10. Dropped head syndrome in mitochondriopathy

    OpenAIRE

    Finsterer, J

    2004-01-01

    In a 63-year-old, 165-cm-tall woman with a history of repeated tick bites, dilative cardiomyopathy, osteoporosis, progressive head ptosis with neck stiffness and cervical pain developed. The family history was positive for thyroid dysfunction and neuromuscular disorders. Neurological examination revealed prominent forward head drop, weak anteflexion and retroflexion, nuchal rigidity, weakness of the shoulder girdle, cogwheel rigidity, and tetraspasticity. The lactate stress test was abnormal....

  11. Sensory neuropeptides and nitric oxide in nasal vascular regulation

    OpenAIRE

    Rinder, Johan

    1996-01-01

    Sensory neuropeptides and nitric oxide in nasal vascular regulation By Johan Rinder, M.D. Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institute, S- 171 77 Stockholm, Sweden and Department of Oto-Rhino-Laryngology, Karolinska Hospital, S-17176 Stockholm, SwedenThe role of sensory neuropeptides and nitric oxide in vascular regulation was investigated in the pig nasal mucosa...

  12. Resident aerobic microbiota of the adult human nasal cavity

    DEFF Research Database (Denmark)

    Rasmussen, TT; Kirkeby Nielsen, LP; Poulsen, Knud;

    2000-01-01

    Recent evidence strongly suggests that the microbiota of the nasal cavity plays a crucial role in determining the reaction patterns of the mucosal and systemic immune system. However, little is known about the normal microbiota of the nasal cavity. The purpose of this study was to determine the m...

  13. Nasal cytochrome P4502A: Identification in rats and humans

    Energy Technology Data Exchange (ETDEWEB)

    Thornton-Manning, J.R.; Hotchkiss, J.A. [Michigan State Univ., East Lansing, MI (United States); Ding, Xinxin [Wadsworth Center for Laboratories and Research, Albany, NY (United States)] [and others

    1995-12-01

    The nasal mucosa, the first tissue of contact for inhaled xenobiotics, possesses substantial enobiotic-metabolizing capacti. Enzymes of the nasal cavity may metabolize xenobiotics to innocuous, more water-soluble compounds that are eliminated from the body, or they may bioactivate them to toxic metabolites. These toxic metabolites may find to cellular macromolecules in the nasal cavity or be transported to other parts of the body where they may react. Nasal carcinogenesis in rodents often results from bioactivation of xenobiotics. The increased incidences of nasal tumors associated with certain occupations suggest that xenobiotic bioactivation may be important in human nasal cancer etiology, as well. The increasing popularity of the nose as a route of drug administration makes information concerning nasal drug metabolism and disposition vital to accomplish therapeutic goals. For these reasons, the study of xenobiotic-met abolizing capacity of the nasal cavity is an important area of health-related research. In the present study, we have confirmed the presence of CYP2A6 mRNA in human respiratory mucosa.

  14. Polyvinyl siloxane: novel material for external nasal splinting.

    Science.gov (United States)

    Jayakumar, N K; Rathnaprabhu, V; Ramesh, S; Parameswaran, A

    2016-01-01

    External nasal splinting is performed routinely after nasal bone fracture reductions, osteotomies, and rhinoplasties. Materials commonly used include plaster of Paris (POP), thermoplastic splints, self-adhesive padded aluminium splints, and Orthoplast, among many others. The disadvantages of these materials are described in this paper, and polyvinyl siloxane is recommended as an effective and more readily available alternative material to counter these pitfalls.

  15. Non-coalescence of oppositely charged drops

    CERN Document Server

    Ristenpart, W D; Belmonte, A; Dollar, F; Stone, H A

    2009-01-01

    Oppositely charged drops have long been assumed to experience an attractive force that favors their coalescence. In this fluid dynamics video we demonstrate the existence of a critical field strength above which oppositely charged drops do not coalesce. We observe that appropriately positioned and oppositely charged drops migrate towards one another in an applied electric field; but whereas the drops coalesce as expected at low field strengths, they are repelled from one another after contact at higher field strengths. Qualitatively, the drops appear to `bounce' off one another. We directly image the transient formation of a meniscus bridge between the bouncing drops.

  16. The nasal distribution of metered dose inhalers.

    Science.gov (United States)

    Newman, S P; Morén, P F; Clarke, S W

    1987-02-01

    The intranasal distribution of aerosol from a metered dose inhaler has been assessed using a radiotracer technique. Inhalers were prepared by adding 99Tcm-labelled Teflon particles (simulating the drug particles) to chlorofluorocarbon propellants, and scans of the head (and chest) taken with a gamma camera. Ten healthy subjects (age range 19-29 years) each performed two radioaerosol studies with the inhaler held in two different ways: either in a single position (vial pointing upwards) or in two positions (vial pointing upwards and then tilted by 30 degrees in the sagittal plane). The vast majority of the dose (82.5 +/- 2.8 (mean +/- SEM) per cent and 80.7 +/- 3.1 per cent respectively for one-position and two-position studies) was deposited on a single localized area in the anterior one-third of the nose, the initial distribution pattern being identical for each study. No significant radioaerosol was detected in the lungs. Only 18.0 +/- 4.7 per cent and 15.4 +/- 4.1 per cent of the dose had been removed by mucociliary action after 30 minutes, and it is probable that the remainder had not penetrated initially beyond the vestibule. Since the deposition pattern was highly localized and more than half the dose probably failed to reach the turbinates it is possible that the overall effect of nasal MDIs is suboptimal for the treatment of generalized nasal disorders.

  17. Treatment of nasal polyposis in Byzantine times.

    Science.gov (United States)

    Lascaratos, J G; Segas, J V; Assimakopoulos, D A

    2000-09-01

    The goal of this study was to describe the therapeutic methods and surgical techniques used during Byzantine times (AD 324-1453) for a disease that has occupied physicians since antiquity: nasal polyps. The original Greek-language texts of the Byzantine medical writers, most of which were published after the 17th century, were studied in order to identify the early knowledge of the definition, symptoms, conservative treatments, and surgical intervention in cases of this disease. A considerable number of conservative treatments, etiologic and local (with inunctions or blowing of caustic substances), with evident influence from Roman medicine, were identified even in the early Byzantine medical texts (4th century). Further, some surgical techniques were described that seem to constitute evolution of the Hippocratic tradition. From the study of the original texts of Byzantine medical writers, their interest in the rhinological diseases is evident; in the case of nasal polyps, new techniques were mentioned. The first meticulous intranasal surgical removal of polyps was described. These techniques, obviously developed during the Hellenistic period, initially influenced European medicine and later the rest of the world. PMID:11007093

  18. A Case of Nasal Glial Heterotopia in an Adult

    Directory of Open Access Journals (Sweden)

    Akira Hagiwara

    2014-01-01

    Full Text Available We report a rare case of nasal glial heterotopia in an adult. After the surgery, frontal lobe cerebral hemorrhage developed. A 58-year-old man had unilateral nasal obstruction that progressed for one year. He had been treated for hypertension, chronic heart failure, and cerebral infarction with aspirin and warfarin. A computed tomography scan showed that the tumor occupied the right nasal cavity and the sinuses with small defect in the cribriform plate. The tumor was removed totally with endoscopy. After the operation, the patient developed convulsions and frontal lobe cerebral hemorrhage. The hemorrhage site was located near a defect in the cribriform plate. Nasal glial heterotopia is a rare developmental abnormality, particularly rare in adult. Only few cases were reported. We could not find any report of adult nasal glial heterotopias that developed cerebral hemorrhage as a complication of the surgery.

  19. Nasal polyps. A clinical radiological histopathological and mycological study

    International Nuclear Information System (INIS)

    Forty patients with nasal polyposis were studied. This study included clinical, haematological and mycological aspects. There were 24 females (60% of patients) and 16 males (40%). We found that all patients presented with nasal obstruction and nasal tone and the majority of them had allergic nasal symptoms such as sneezing and watery discharge. Thirty five percent of the patients were recurrent cases, being operated before for nasal polyps. Radiological investigations showed high of sinusitis and that 10% of the patients had complicated disease with orbital or intracranial extensions. Mycological studies revealed the presence of fungal infection in 4 patient (10%) and it was caused by Aspergillus flavus. Histological studies identified the allergic nature of the polyps in all patients. Surgical treatment was carried out in all patients and operations varied from simple intranasal polypectomy, intranasal ethmiodectomy, external ethmoidectomy to Caldwell-Luc operation for patients with antrochanal polyps.(Author)

  20. Granuloma nasal (rinite atópica de bovinos Bovine nasal granuloma (atopic Rhinitis

    Directory of Open Access Journals (Sweden)

    Adriana Lücke Stigger

    2001-06-01

    Full Text Available Granuloma nasal ocorreu em 13 bovinos Jersey, fêmeas, com idades entre 9 meses e 3 anos, em uma propriedade de Pinhal Grande, Rio Grande do Sul. Sinais clínicos incluíam corrimento nasal seroso ou mucoso, às vezes com estrias de sangue, espirros, respiração ruidosa, dificuldade em respirar, lacrimejamento, congestão dos vasos da esclera e roçar o focinho em árvores e outros objetos. Os sinais clínicos se exacerbavam após exercício. No exame clínico de 10 bovinos, foram observados nódulos na mucosa da porção proximal da cavidade nasal. Na citologia do corrimento nasal de 9 bovinos, observaram-se eosinófilos em números diretamente proporcionais à intensidade dos sinais clínicos. Não houve alterações no hemograma. Um dos animais afetados foi sacrificado e necropsiado. As principais alterações macroscópicas observadas foram nódulos polipóides firmes, branco-alaranjados, multifocais, com 2 a 4mm de diâmetro, agrupados na porção proximal das fossas nasais. No exame histológico, os nódulos consistiam de epitélio respiratório hiperplásico, com metaplasia escamosa, sobre uma proliferação fibrovascular acentuadamente infiltrada por eosinófilos e, em menor grau, por, macrófagos e plasmócitos.Nasal granuloma affecting 13 female Jersey cattle with ages ranging from 9 months to 3-year-old occurred in a farm in Pinhal Grande, Rio Grande do Sul, Brazil. Clinical signs included serous to serosanguineous or mucous nasal discharge, snoring, sniffling, difficult in breathing, lacrimation, congestion of the vessels of the sclera and rubbing the nose against trees and other hard surfaces. Clinical signs were exacerbated by exercise. The clinical examination of 10 affected cattle revealed small nodules in the mucous membrane of the proximal portion of the nasal cavity. Cytology carried out in the nasal discharge of 9 affected cattle revealed mainly eosinophils in numbers directly proportional to the severity of clinical signs

  1. Seasonal changes in nasal cytology in mite-allergic patients

    Directory of Open Access Journals (Sweden)

    Gelardi M

    2014-03-01

    Full Text Available Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs are a major cause of allergic rhinitis (AR and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens

  2. Star-shaped Oscillations of Leidenfrost Drops

    CERN Document Server

    Ma, Xiaolei; Burton, Justin C

    2016-01-01

    We experimentally investigate the self-organized, star-shaped oscillations of Leidenfrost drops. The drops levitate on a cushion of evaporated vapor over a heated, curved surface. We observe modes with $n = 2-13$ lobes around the drop periphery. We find that both the wavelength and frequency of the oscillations depend only on the capillary length of the liquid, and are independent of the drop radius and substrate temperature. However, the number of observed modes depend sensitively on the liquid viscosity. The dominant frequency of pressure variations under the drop is approximately twice that the drop oscillation frequency, consistent with a parametric forcing mechanism. Our results suggest that the star-shaped oscillations are hydrodynamic in origin, and are driven by capillary waves beneath the drop. The exact mechanism by which the vapor flow initiates the capillary waves is likely related to static "brim waves" in levitated, viscous drops.

  3. Drop In - Experience the Taste

    OpenAIRE

    Lal, Sanjeev

    2014-01-01

    Wine is a growing industry and there are over 75,000 types of wine. Consumers are intimidated by the selection of wine and are afraid to ask questions of friends, bartenders, and retailers. Uneducated consumers also are reluctant to request samples of wine at liquor establishments. There are very few establishments in the downtown Vancouver area that offer a venue to sample the wine or educate the consumer. Drop In is an establishment that offers a pour or glass of different types of wine fro...

  4. Phenylephrine as an alternative to cocaine for nasal vasoconstriction before nasal surgery: A randomised trial

    Directory of Open Access Journals (Sweden)

    Sawsan T AlHaddad

    2013-01-01

    Full Text Available Background: Cocaine is often used topically to provide the profound vasoconstriction required for nasal surgery; however, it has been associated with intraoperative cardiac adverse effects. We compared cocaine with phenylephrine as an alternative to ascertain their relative efficacy as vasoconstrictors in nasal septoplasty. Methods: Adult patients, presenting for elective nasal septoplasty, of American Society of Anaesthesiologists physical status I-III, were randomised to either 0.5% phenylephrine or 4% cocaine. The primary outcome was quality of vasoconstriction on a 5-point scale (1=unacceptable, 5=excellent, rated by the surgeon at the end of the procedure. Results: Twenty-nine patients received phenylephrine and 26 received cocaine. The median rating for quality of the vasoconstriction was 4.0 (good in both the phenylephrine and cocaine groups ( P=0.84. Median blood loss was 50 ml in the phenylephrine group and 62.5 ml in the cocaine group ( P=0.49. In secondary analyses, phenylephrine was shown to be non-inferior to cocaine on both quality of vasoconstriction (non-inferiority delta of 1 point, P=0.009 and estimated blood loss (non-inferiority delta of 25 ml, P=0.028. The frequency of ventricular ectopy, ST segment changes or blood pressure changes after nasal packing was not significantly different between the two groups. Conclusion: Phenylephrine in a concentration of 0.5% is not different from 4% cocaine on the quality of vasoconstriction in septoplasty. Given the abuse potential of cocaine and the added administrative burden associated with its handling, phenylephrine might serve as an alternative.

  5. Non-Hodgkin's lymphoma of nasal cavity: CT diagnosis

    International Nuclear Information System (INIS)

    Objective: To study the CT imaging of nasal lymphomas and find out the relatively specific manifestations of CT imaging of nasal lymphomas. Methods: The CT imaging material of 10 nasal lymphomas confirmed pathologically and evaluate the diagnostic significance of the manifestations of the images combined with review of literatures. Results: The pathology of all 10 cases of nasal lymphomas were T cell Non-Hodgkin's lymphoma (NHL), Ann Arbor stage I-II in 9 and 1 in stage IV. The locations of 10 lymphomas were in the anterior portion of one of the nasal cavities, and the lymphomas extended posteriorly along the inferior and/or media nasalis concha in different extent. No bone structure destruction was found in all stage I cases and the bone of the media nasalis concha as well as the uncinate process was partially absorbed in the stage IV NHL. The skin of the external noses adjacent to the lymphoma of the whole 10 cases were swollen in various severity with disappearance of the subcutaneous fat. Conclusion: If that the tumor located in the anterior portion of nasal cavity, without destruction or deformation of the bone structure, the skin of the external nose adjacent to the tumor was swollen and/or the subcutaneous fat was disappeared shown by CT, the possibility of nasal lymphoma should be considered

  6. Results of rhinoplasties of the nasal tip in Cienfuegos

    Directory of Open Access Journals (Sweden)

    Bernardo Félix Canto Vidal

    2015-04-01

    Full Text Available Background: the rhinoplasty of the nasal tip is one of the most difficult and challenging plastic surgeries the surgeon dedicated to the nasal deformities faces. Objective: exposing the results of the rhinoplasty accomplished to patients with nasal deformities. Methods: a descriptive study of results obtained in 145 patients who had a surgery to correct nasal deformities. They were attended at Dr. Gustavo Aldereguía Lima University General Hospital of Cienfuegos, in a period of 10 years. Results: in 56 patients surgery was headed for embracing the nasal tip; in 45 patients to the rotation of the nasal tip; and in 44 patients to the projection of the nasal tip. The technique of the banner with graft of cartilage of the septum and the ear was used. Conclusion: in the analyzed period, the rhinoplasty accomplished in the province of Cienfuegos had satisfactory results, because the patient’s expectations were satisfied with a reduction of the costs of risks for them due to the use of local anesthesia.

  7. Sense of smell in patients with bilateral nasal polyposis

    Directory of Open Access Journals (Sweden)

    Savović Slobodan N.

    2004-01-01

    Full Text Available Introduction Sense of smell is susceptible to various changes, both in physiological and in numerous pathological conditions. Of quantitative disorders of smell, hyposmia and anosmia are quite common, whereas of qualitative disorders parosmia is most frequent. The aim of this paper was to examine impact of bilateral nasal polyposis on olfactory function. Material and methods The research was carried out at the Nose, Ear and Throat Clinic in Novi Sad. It included 80 examinees, 40 (20 male, 20 female with bilateral nasal polyposis, while 40 examinees belonged to the control group (20 male, 20 female without symptoms of nasal polyposes. Fortunato-Niccolini olfactometer was used for this examination. Results and discussion In patients with bilateral nasal polyposis the average perception threshold values for examined odors were 15.50 ccm of odorous air, while in the control group they were 10,20 ccm of odorous air. The average identification threshold values for examined odors in patients with bilateral nasal polyposis were 18.80 ccm of odorous air, while in the control group they were 13.55 ccm of scented air. T-test showed that values of both tresholds were statistically significantly higher (p< 0,01 in patients with bilateral nasal polyposis in relation to the control group. Conclusion Olfactory deficit in patients with bilateral nasal polyposis is explained by difficult or impossible passage of odors into the olfactory region.

  8. An approach to the nasal septum in children.

    Science.gov (United States)

    Healy, G B

    1986-11-01

    Surgery of the nasal septum has long been discouraged in the pediatric population. Concerns about growth and development of the nose have led surgeons to adopt an extremely cautious attitude toward the correction of nasal septal deformities in childhood. More recently, studies have shown that with proper preservation of septal cartilage, surgery can be safely undertaken in this area. Frequently, however, exposure to the nasal septum is limited in small children due to the size of the nasal vestibule. Sublabial septoplasty has been safely carried out now in ten patients ranging in age from 4 to 9 years. This approach allows for complete access to the nasal septum while avoiding any external cosmetic deformity. The nasal septum has been preserved in all cases through morsalization and repositioning. Growth and development of the nose has been followed for up to 60 months without evidence of deformity or alteration. Sublabial septoplasty would, therefore, appear to be a safe and cosmetically acceptable approach to the correction of severe nasal septal deformities of childhood. PMID:3773624

  9. NASAL IN SITU GEL: A NOVEL DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Dhrupesh panchal

    2012-06-01

    Full Text Available Over the past few decades, advances in the in situ gel technologies have spurred development in manymedical and biomedical applications including controlled drug delivery. Many novel in situ gel baseddelivery matrices have been designed and fabricated to fulfill the ever increasing needs of thepharmaceutical and medical fields. In situ gelling systems are liquid at room temperature but undergogelation when in contact with body fluids or change in pH. In situ gel forming drug delivery is a type ofmucoadhesive drug delivery system. The formation of gel depends on factors like temperaturemodulation, pH change, presence of ions and ultraviolet irradiation from which the drug gets released ina sustained and controlled manner. Nasal delivery is a promising drug delivery option where commondrug administrations such as intravenous, intramuscular or oral are inapplicable. Recently, it has beenshown that many drugs have better bioavailability by nasal route than the oral route. This has beenattributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled withavoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in thegastrointestinal tract. The physiology of the nose presents obstacles but offers a promising route for noninvasivesystemic delivery of numerous therapies and debatably drug delivery route to the brain. Thusthis review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal drugabsorption mechanisms, various nasal drug delivery systems and their applications in drug delivery.

  10. PRL-3 expression in nasal sinus squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Zi-Hui Chen; Min-Ying Li

    2016-01-01

    Objective:To investigate the relationship between liver regeneration phosphatase-3 (PRL-3) with differentiation extent of nasal sinus squamous cell carcinoma, and molecular biological effects on the pathogenesis of nasal sinus squamous cell carcinoma to comprehend its relevance, so as to make early diagnosis of patients, and to give guidance to the prognosis. Methods:Immunohistochemistry was used to detect PRL-3 in 30 cases of different degrees of sinus nasal squamous cell carcinoma. 20 cases of normal nasal cavity of mucosa tissues were set as control. Results:The PRL-3 in all levels of sinonasal squamous cell carcinoma tissues, there was a significant difference compared with the normal nasal mucosa (P<0.05), squamous cell carcinoma and its expression increased with the grade with enhanced trend. Conclusions:PRL-3 expression increased significantly in sinonasal squamous cell carcinoma than in nasal polyp tissue, showed that it may be associated with squamous cell carcinoma of nasal sinus squamous cell carcinoma, may be the early event.

  11. Brain-targeted nasal clonazepam microspheres

    Directory of Open Access Journals (Sweden)

    Shaji J

    2009-01-01

    Full Text Available Gelatin-chitosan mucoadhesive microspheres of clonazepam were prepared using the emulsion cross linking method. Mirospheres were evaluated using the in vitro and ex vivo drug release patterns. In vivo CNS drug distribution studies were carried out in rats by administering the clonazepam microspheres intra-nasally and clonazepam solution intravenously. From the drug levels in plasma and CSF, drug targeting index and drug targeting efficiency were calculated. Results obtained indicated that intranasally administered clonazepam microspheres resulted in higher brain levels with a drug targeting index of 2.12. Gelatin-chitosan cross linked mucoadhesive microspheres have the potential to be developed as a brain-targeted drug delivery system for clonazepam.

  12. Intra And Extra Nasal Laser Surgery

    Science.gov (United States)

    Selking, Stuart G.

    1988-06-01

    The author describes his experience with 400 intranasal laser surgical procedures done with the carbon dioxide laser and the surgical microscope. Procedures include excision and vaporization of polyps, turbinates, tumors, telangiectasia, synechia, nasal stenosis, intranasal cysts, papillomata, and septal spurs. The author describes a suction speculum and drape of his own design which provide smoke free access to the internal nose, and protection of the alar rim and the face from laser energy. Relief of obstruction is comparable to that obtained from the more traditional means of intranasal surgery. Intraoperative and early and delayed post operative bleeding is less with laser surgery than with any other means. Avoidance of technical problems is emphasized in this manuscript, since intranasal laser surgery is in some respects difficult to perform. Included are practical suggestions about patient positioning, use of protective devices, and patient selection.

  13. Electrohydrodynamics of a viscous drop with inertia

    Science.gov (United States)

    Nganguia, H.; Young, Y.-N.; Layton, A. T.; Lai, M.-C.; Hu, W.-F.

    2016-05-01

    Most of the existing numerical and theoretical investigations on the electrohydrodynamics of a viscous drop have focused on the creeping Stokes flow regime, where nonlinear inertia effects are neglected. In this work we study the inertia effects on the electrodeformation of a viscous drop under a DC electric field using a novel second-order immersed interface method. The inertia effects are quantified by the Ohnesorge number Oh, and the electric field is characterized by an electric capillary number CaE. Below the critical CaE, small to moderate electric field strength gives rise to steady equilibrium drop shapes. We found that, at a fixed CaE, inertia effects induce larger deformation for an oblate drop than a prolate drop, consistent with previous results in the literature. Moreover, our simulations results indicate that inertia effects on the equilibrium drop deformation are dictated by the direction of normal electric stress on the drop interface: Larger drop deformation is found when the normal electric stress points outward, and smaller drop deformation is found otherwise. To our knowledge, such inertia effects on the equilibrium drop deformation has not been reported in the literature. Above the critical CaE, no steady equilibrium drop deformation can be found, and often the drop breaks up into a number of daughter droplets. In particular, our Navier-Stokes simulations show that, for the parameters we use, (1) daughter droplets are larger in the presence of inertia, (2) the drop deformation evolves more rapidly compared to creeping flow, and (3) complex distribution of electric stresses for drops with inertia effects. Our results suggest that normal electric pressure may be a useful tool in predicting drop pinch-off in oblate deformations.

  14. Small drops from large nozzles

    Science.gov (United States)

    Castrejon-Pita, Alfonso Arturo; Said Mohamed, Ahmed; Castrejon-Pita, Jose Rafael; Herrada, Miguel Angel

    2015-11-01

    We report experimental and numerical results of the generation of drops which are significantly smaller than the nozzle from which they are generated. The system consists of a cylindrical reservoir and two endplates. One plate is a thin metal sheet with a small orifice in its centre which acts as the nozzle. The other end consists of a piston which moves by the action of an elecromechanical actuator which in turn is driven by sine-shape pull-mode pulses. The meniscus (formed at the nozzle) is thus first overturned, forming a cavity. This cavity collapses and a thin and fast jet emerges from its centre. Under appropriate conditions the tip of this jet breaks up and produces a single diminutive drop. A good agreement between the experimental and numerical results was found. Also, a series of experiments were performed in order to study the effects that the pulse amplitude and width, together with variations in the liquid properties, have over the final size of the droplet. Based on these experiments, a predictive law for the droplet size has been derived. This work was funded by the Royal Society (University Research Fellowship and Research Grant), the John Fell Fund (Oxford University Press), the Ministry of Science and Education (DPI2013-46485 Spain), and the Junta de Andalucia (P08-TEP-31704128 Spain).

  15. Clinical study and image diagnosis of nasal bone fracture

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Takenori; Suzuki, Naohiro; Okitsu, Takuji [Sendai City Hospital (Japan)

    2002-01-01

    In this study we reviewed the clinical features, diagnoses and treatments of 232 cases of nasal bone fracture cases treated at our department from January 1994 to June 2000. A marked predominance of males in the age range of 10-29 years was noted. Analysis of the causes of the nasal fractures were attributed to fighting (66 cases), traffic accidents (64 cases), sports (56 cases) and others (46 cases). The external appearance of nasal fractures were divided into 5 types, 85 cases of the displacement type, 27 cases of the depressed type, 32 of the mixed type, 56 of the non-deformation type and 32 of the unclassified type because of facial swelling. The sensitivity of conventional X-ray examination in identifying nasal fractures was 75.6%. Computed tomography scan (CT scan) was performed in 196 patients and showed that the middle and lower portions of nasal bones were fractured more easily than those of the upper portion. Nasal septum fracture occurred in 22 cases (11.2%). Other facial fractures combined with nasal fracture were found in 40 cases (20.4%). The type of combined fracture depended on the cause of the injury, for example, the combination of nasal and blow-out fracture was often caused by fighting, and many combined fractures of more than two facial bones resulted from traffic accidents. A total of 83 patients (35.8%) received reduction of the nasal bone fractures under general anaesthesia. The measurement of irradiation of each radiological examination revealed that the exposed dose of the newest model CT was similar to that of the conventional X-ray examination and tomography. (author)

  16. Levocabastine eye drops are effective and well tolerated for the treatment of allergic conjunctivitis in children

    Directory of Open Access Journals (Sweden)

    Brunello Wüthrich

    1995-01-01

    Full Text Available This open-label, prospective, multicentre, 4-week trial was undertaken to assess the efficacy and tolerability of twice daily levocabastine eye drops (0.5 mg/ml, with sodium cromoglycate nasal spray for the relief of concurrent nasal symptoms if required, in a total of 233 children with seasonal allergic conjunctivitis. No correlation between efficacy, tolerability and age was found. Investigator assessments revealed that the total severity of ocular symptoms decreased by 84 ± 34% in patients < 12 years and 85 ± 30% in those ≥ 12 years, with corresponding reductions in the total severity of ocular findings of 84% in both patient groups over the 4-week treatment period. Global assessments of therapeutic efficacy revealed the effect of therapy on ocular symptoms to be excellent or good in 81% of patients < 12 years and 82% of those ≥ 12 years after 2 weeks of treatment, with corresponding values at the end of the trial of 88% and 82% in the two groups, respectively. Treatment tolerability was considered to be excellent or good by 94% of patients overall. Application site reactions were the most common adverse event associated with ocular levocabastine, occurring in 13% of patients < 12 years and 9% of those ≥ 12 years. Twice daily levocabastine eye drops therefore appear to be effective and well tolerated for the treatment of seasonal allergic conjunctivitis in children.

  17. Vibration-induced climbing of drops

    CERN Document Server

    Brunet, P; Deegan, R D

    2008-01-01

    We report an experimental study of liquid drops moving against gravity, when placed on a vertically vibrating inclined plate, which is partially wetted by the drop. The frequency of vibrations ranges from 30 to 200 Hz, and, above a threshold in vibration acceleration, drops experience an upward motion. We attribute this surprising motion to the deformations of the drop, as a consequence of an up or down symmetry breaking induced by the presence of the substrate. We relate the direction of motion to contact angle measurements. This phenomenon can be used to move a drop along an arbitrary path in a plane, without special surface treatments or localized forcing.

  18. Using acoustic sensors to discriminate between nasal and mouth breathing.

    Science.gov (United States)

    Curran, Kevin; Yuan, Peng; Coyle, Damian

    2012-01-01

    The recommendation to change breathing patterns from the mouth to the nose can have a significantly positive impact upon the general well being of the individual. We classify nasal and mouth breathing by using an acoustic sensor and intelligent signal processing techniques. The overall purpose is to investigate the possibility of identifying the differences in patterns between nasal and mouth breathing in order to integrate this information into a decision support system which will form the basis of a patient monitoring and motivational feedback system to recommend the change from mouth to nasal breathing.

  19. A Case of Enzootic Nasal Adenocarcinoma in a Ewe

    Directory of Open Access Journals (Sweden)

    Devorah Marks Stowe

    2012-01-01

    Full Text Available An approximately 2-year-old open Suffolk ewe presented to the North Carolina State University College of Veterinary Medicine Veterinary Health Complex for evaluation of a left nasal mass. An ultrasound-guided aspirate and core biopsies were performed. An epithelial neoplasia with mild mixed inflammation (neutrophils and plasma cells was diagnosed on cytology and confirmed on histopathology. Immunohistochemistry (IHC, reverse transcriptase polymerase chain reaction (RT-PCR, and transmission electron microscopy were also performed. IHC and RT-PCR identified the presence of enzootic nasal tumor virus and confirmed the final diagnosis of enzootic nasal adenocarcinoma.

  20. Unstable Leidenfrost Drops on Roughened Surfaces

    CERN Document Server

    Boreyko, Jonathan B

    2010-01-01

    Drops placed on a surface with a temperature above the Leidenfrost point float atop an evaporative vapor layer. In this fluid dynamics video, it is shown that for roughened surfaces the Leidenfrost point depends on the drop size, which runs contrary to previous claims of size independence. The thickness of the vapor layer is known to increase with drop radius, suggesting that the surface roughness will not be able to penetrate the vapor layer for drops above a critical size. This size dependence was experimentally verified: at a given roughness and temperature, drops beneath a critical size exhibited transition boiling while drops above the critical size were in the Leidenfrost regime. These Leidenfrost drops were unstable; upon evaporation down to the critical size the vapor film suddenly collapsed.

  1. Ultrasonic Vibration Suspends Large Pendant Drops

    Institute of Scientific and Technical Information of China (English)

    HONG Zhen-Yu; XIE Wen-Jun; WEI Bing-Bo

    2009-01-01

    A stationary substrate can suspend only small pendant drops even with excellent wetting ability because of gravity. We report the suspension of large pendant water drops by a copper substrate that vibrates ultrasonically with a frequency of 22 kHz. The mass of the largest pendant drop suspended by the vibrating substrate reaches 1.1 g, which is 9 times that by the same stationary substrate. The pendant drop deforms drastically and quickly at both the beginning and the end of the vibration procedure. As the vibration power increases, the contact area between the drop and substrate expands and the drop height shrinks accordingly. Theoretical analysis indicates that the Bernoulli pressure induced by ultrasonic vibration may contribute strongly to enhancing the suspensibility of pendant drops.

  2. Drop shaping by laser-pulse impact

    CERN Document Server

    Klein, Alexander L; Visser, Claas Willem; Lhuissier, Henri; Sun, Chao; Snoeijer, Jacco H; Villermaux, Emmanuel; Lohse, Detlef; Gelderblom, Hanneke

    2015-01-01

    We study the hydrodynamic response of a falling drop hit by a laser pulse. Combining high-speed with stroboscopic imaging we report that a millimeter-sized dyed water drop hit by a milli-Joule nanosecond laser-pulse deforms and propels forward at several meters per second, until it eventually fragments. We show that the drop motion results from the recoil momentum imparted at the drop surface by water vaporization. We measure the propulsion speed and the time-deformation law of the drop, complemented by boundary integral simulations. We explain the drop propulsion and shaping in terms of the laser pulse energy and drop surface tension. These findings are crucial for the generation of extreme ultraviolet (EUV) light in lithography machines.

  3. [Nasal breath recovery and rhinoplasty in cleft lip and palate patient with unilateral choanal atresia].

    Science.gov (United States)

    Chkadua, T Z; Ivanova, M D; Daminov, R O; Brusova, L A; Savvateeva, D M

    2016-01-01

    The paper presents the analysis of clinical case of endoscopic nasal breath restoration and elimination of the secondary cleft lip nasal deformity in 27 years old patient with unilateral choanal atresia and secondary nasal deformity after rhinocheiloplasty. Preoperative examination revealed the absence of nasal breathing on collateral side due to complete bone choanal atresia. Surgical treatment included endoscopic choanal repair, elimination of the secondary nasal deformity, septoplasty, conchotomy and lateroposition of the inferior conchae. The treatment resulted in nasal breath restoration and elimination of nasal deformity. Long-term follow-up at 1 and 12 months post-operatively proved stable positive aesthetic and functional results. PMID:26925564

  4. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    OpenAIRE

    Wadell, Cecilia

    2002-01-01

    Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. Porcine nasal mucosa mounted in an Ussing chamber sys...

  5. Oxygenation and Exercise Performance-Enhancing Effects Attributed to the Breathe-Right Nasal Dilator

    OpenAIRE

    Trocchio, Marc; Fisher, Jean; Wimer, Jeffrey W.; Parkman, Anna W.

    1995-01-01

    Recently, many professional football players have elected to wear spring-loaded nasal dilators during competition. Many athletes believe that wearing the “Breathe-Right” nasal dilator will increase nasal gas conduction and oxygenation to their body, subsequently improving their performance. The purpose of this experiment was to investigate the advantages of wearing a nasal dilator while performing aerobic and anaerobic exercise, as opposed to not wearing a nasal dilator. It was hypothesized t...

  6. Preliminary stages before nasal reconstruction using forehead flap: restoring perinasal subunits and nostril patency

    Directory of Open Access Journals (Sweden)

    Victor Diniz de Pochat

    2015-03-01

    Full Text Available Due to the complex three-dimensional structure of the nose, the repair of the nasal defect requires reconstruction of three different layers: skin envelope, osteocartilaginous framework and nasal lining. Before nasal reconstruction can be accomplished, the nose must rest on a stable platform to avoid late nasal obstructions, and septal deviations resulting from scar contraction. We present three cases of nasal reconstruction using a forehead flap in which we performed a preliminary stage to increase reliability of outcomes.

  7. Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies.

    Science.gov (United States)

    Sintov, Amnon C; Levy, Haim V; Botner, Shafir

    2010-12-01

    The main purpose of this study was to investigate the nasal absorption of insulin from a new microemulsion spray preparation in rabbits. The bioavailability of insulin lispro via the nasal route using a W/O microemulsion was found to reach 21.5% relative to subcutaneous administration, whereas the use of an inverse microemulsion as well as a plain solution yielded less than 1% bioavailability. The profile of plasma glucose levels obtained after nasal spray application of the microemulsion (1IU/kg lispro) was similar to the subcutaneous profile of 0.5IU/kg at the first 90min after application and resulted in a 30-40% drop in glucose levels. The microemulsion system was characterized by DLS, TEM, viscosity measurements, and by construction of pseudo-ternary phase diagram. The average droplet size of an insulin-unloaded and insulin-loaded microemulsions containing 20% aqueous phase (surfactants-to-oil ratio=87:13) was 2nm and 2.26nm in diameter, respectively. In addition, the effect of the microemulsion on FITC-labeled insulin permeation was examined across the porcine nasal mucosa in vitro. The permeability coefficient of FITC-insulin via the microemulsion was 0.210±0.048cm/h with a lag time of 10.9±6.5min, whereas the permeability coefficient from a plain solution was 0.082±0.043cm/h with a lag time of 36.3±10.1min. In view of the absorption differences of insulin between 20%, 50% water-containing microemulsions and an aqueous solution obtained in vitro and in vivo, it has been concluded that the acceleration in the intramucosal transport process is the result of encapsulating insulin within the nano-droplet clusters of a W/O microemulsion, while the microemulsion ingredients seems to have no direct role. PMID:20709120

  8. Nasal Aspergillosis in a Dog: A Case Report

    Directory of Open Access Journals (Sweden)

    Camilo Padilla Peñuela

    2014-07-01

    Full Text Available Nasal aspergillosis is a major chronic disease affecting the nostrils in dogs. Clinical sinology is typical in every chronic nasal disease. Epistaxis and occasional pain occurs. Rhinoscopic assessment of the area evidences findings associated with the pathology and allows collecting samples for cytology and culture. Systemic therapy with oral antifungals has had variable utility, but now it has been replaced by direct topical medication to the affected area. This article describes the case of a 4-years-old male dog, submitted to consultation by unilateral muco-bloody nasal discharge with a week of evolution. The patient was treated by another vet center with cyclonamine and vitamin K for a possible clotting disorder. After a series of tests that included rhinoscopy and fungal culture, nasal aspergillosis was diagnosed. Intranasal clotrimazole was applied twice and it allowed the resolution of the clinical signs.

  9. Zicam-induced damage to mouse and human nasal tissue.

    Directory of Open Access Journals (Sweden)

    Jae H Lim

    Full Text Available Intranasal medications are used to treat various nasal disorders. However, their effects on olfaction remain unknown. Zicam (zinc gluconate; Matrixx Initiatives, Inc, a homeopathic substance marketed to alleviate cold symptoms, has been implicated in olfactory dysfunction. Here, we investigated Zicam and several common intranasal agents for their effects on olfactory function. Zicam was the only substance that showed significant cytotoxicity in both mouse and human nasal tissue. Specifically, Zicam-treated mice had disrupted sensitivity of olfactory sensory neurons to odorant stimulation and were unable to detect novel odorants in behavioral testing. These findings were long-term as no recovery of function was observed after two months. Finally, human nasal explants treated with Zicam displayed significantly elevated extracellular lactate dehydrogenase levels compared to saline-treated controls, suggesting severe necrosis that was confirmed on histology. Our results demonstrate that Zicam use could irreversibly damage mouse and human nasal tissue and may lead to significant smell dysfunction.

  10. Reconstruction of the Nasal Septum Using Polydioxanone Plate

    NARCIS (Netherlands)

    M. Boenisch; G.J.N. Trenite

    2010-01-01

    Objectives: To evaluate the usefulness of resorbable polydioxanone plate attached to nasal septal cartilage in external septoplasty, to assess its mechanical stability until healing of cartilage fragments, and to describe the surgical technique and clinical experience. Design: External septoplasty w

  11. Leidenfrost drops on a heated liquid pool

    Science.gov (United States)

    Maquet, L.; Sobac, B.; Darbois-Texier, B.; Duchesne, A.; Brandenbourger, M.; Rednikov, A.; Colinet, P.; Dorbolo, S.

    2016-09-01

    We show that a volatile liquid drop placed at the surface of a nonvolatile liquid pool warmer than the boiling point of the drop can be held in a Leidenfrost state even for vanishingly small superheats. Such an observation points to the importance of the substrate roughness, negligible in the case considered here, in determining the threshold Leidenfrost temperature. A theoretical model based on the one proposed by Sobac et al. [Phys. Rev. E 90, 053011 (2014), 10.1103/PhysRevE.90.053011] is developed in order to rationalize the experimental data. The shapes of the drop and of the liquid substrate are analyzed. The model notably provides scalings for the vapor film thickness profile. For small drops, these scalings appear to be identical to the case of a Leidenfrost drop on a solid substrate. For large drops, in contrast, they are different, and no evidence of chimney formation has been observed either experimentally or theoretically in the range of drop sizes considered in this study. Concerning the evaporation dynamics, the radius is shown to decrease linearly with time whatever the drop size, which differs from the case of a Leidenfrost drop on a solid substrate. For high superheats, the characteristic lifetime of the drops versus the superheat follows a scaling law that is derived from the model, but, at low superheats, it deviates from this scaling by rather saturating.

  12. Nasal mucosa in workers exposed to formaldehyde: a pilot study.

    OpenAIRE

    Boysen, M; Zadig, E; Digernes, V; Abeler, V; Reith, A.

    1990-01-01

    This study evaluates the histological changes, especially the presence of possible precancerous lesions, in the nasal mucosa of workers exposed to formaldehyde. Nasal biopsies of 37 workers occupationally exposed to formaldehyde for more than five years and 37 age matched referents showed a higher degree of metaplastic alterations in the former group. In addition, three cases of epithelial dysplasia were observed among the exposed. These results indicate that formaldehyde may be potentially c...

  13. [Design of the Rolling Type Nasal Feeding Perfusion Apparatus].

    Science.gov (United States)

    Yu, Dong; Yang, Yonghuan; Hu, Huiqin; Luo, Hongjun; Feng, Yunhao; Hao, Xiali

    2015-09-01

    At present, the existing problem in nasal feeding perfusion apparatus is laborious and instability. Designing the rolling type perfusion apparatus by using a roller pump, the problem is solved. Compared with the traditional perfusion apparatus, the advantage lies in liquid carrying only need once and simulating human swallowing process. Through testing and verification, the apparatus can be used in nasal feeding perfusion for elderly or patients.

  14. Trek1 contributes to maintaining nasal epithelial barrier integrity.

    Science.gov (United States)

    Jiang, Jing; Liu, Jiang-Qi; Li, Jing; Li, Meng; Chen, Hong-Bin; Yan, Hao; Mo, Li-Hua; Qiu, Shu-Qi; Liu, Zhi-Gang; Yang, Ping-Chang

    2015-01-01

    Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This study aims to elucidate the role of the TWIK-related potassium channel-1 (Trek1) in the regulation of the epithelial barrier function of the nasal mucosa. In this study, the levels of Trek1 were assessed by real time RT-PCR and Western blotting. The epithelial barrier function of the rat nasal epithelia was evaluated by the Ussing chamber system. The results showed that Trek1 was detected in the human and rat nasal epithelia, which were significantly lower in patients and rats with allergic rhinitis than that in healthy controls. Exposure to the signature T helper 2 cytokine, interleukin (IL)-4, markedly suppressed the expression of Trek1 in the nasal mucosa via up regulating the expression of the histone deacetylase (HDAC)1. The IL-4-induced rat nasal epithelial barrier dysfunction could be blocked by HDAC1 inhibitor (Trichostatin A), or sodium butyrate, or administration of Clostridium Butyricum. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function. PMID:25778785

  15. Treatment of Rhinitis Sicca Anterior with Ectoine Containing Nasal Spray

    Directory of Open Access Journals (Sweden)

    Uwe Sonnemann

    2014-01-01

    Full Text Available Objectives. The safety and efficacy of ectoine nasal spray and ectoine nasal spray with dexpanthenol in the treatment of rhinitis sicca were evaluated in two studies. Design and Methods. Two noninterventional observational studies were performed to evaluate the efficacy and safety of a nasal spray containing ectoine (study 1 and ectoine/dexpanthenol (study 2 over a period of two weeks including comparable numbers of patients suffering from rhinitis sicca anterior. Patients and physicians were asked to rate the efficacy in reducing symptoms and the tolerability over the treatment phase. Results. The treatment in both studies resulted in a clinical and statistical significant reduction of the main diagnosis parameters, nasal airway obstruction, and crust formation. There was also a significant reduction in the secondary diagnosis parameters in both studies. Importantly, the tolerability was very good. During the whole observational study, neither patients nor doctors stopped the medication due to unwanted effects. Conclusion. Rhinitis sicca could be successfully treated with a nasal spray containing ectoine and a nasal spray combining ectoine with dexpanthenol. The combination of both substances led to slight advantages.

  16. Concha bullosa and the nasal middle meatus obstructive syndrome

    Directory of Open Access Journals (Sweden)

    Perić Aleksandar

    2008-01-01

    Full Text Available Background. Concha bullosa (CB is pneumatization of the middle turbinate and one of the most common anatomic variation of the sinonasal region. It is found in about 25% of the population. Middle meatus obstructive syndrome (MMOS is, usually connected with CB. The main symptoms of this syndrome are headaches, impaired nasal breathing and hyposmia. Headache is the most common symptom and it may occur due to contact between a CB and other structures of the nasal cavity. Case report. We presented a case of 32 year-old-woman with headaches, located in the orbital and the left frontal region. The headaches were intermittent and corresponding to the nasal cycle. After neurologic and alergic examination, endoscopic nasal examination demonstrated a septal deviation to the right side and a large middle turbinate in the left side of the nasal cavity. Coronal computerized tomography (CT of the paranasal sinuses demonstrated the septal deformation and pneumatization of the left middle turbinate. Diagnosis was confirmed by lidocaine test. In the functional endoscopic surgery (FESS, the lateral lamela of the anterior CB was removed. At the same time, the septoplasty was done. At the control examination, the patient was without symptoms. Conclusion. Although CB is the common anatomic variation of the nasal cavity, MMOS is rare. Headache (rhinogenic origin is the most important symptom. Surgical treatment is the lateral resection of the CB in the FESS technique and the septoplasty.

  17. Nasalance and nasality at experimental velopharyngeal openings in palatal prosthesis: a case study

    Science.gov (United States)

    LIMA-GREGIO, Aveliny Mantovan; MARINO, Viviane Cristina de Castro; PEGORARO-KROOK, Maria Inês; BARBOSA, Plinio Almeida; AFERRI, Homero Carneiro; DUTKA, Jeniffer de Cassia Rillo

    2011-01-01

    The use of prosthetic devices for correction of velopharyngeal insufficiency (VPI) is an alternative treatment for patients with conditions that preclude surgery and for those individuals with a hypofunctional velopharynx (HV) with a poor prognosis for the surgical repair of VPI. Understanding the role and measuring the outcome of prosthetic treatment of velopharyngeal dysfunction requires the use of tools that allow for documenting pre- and post-treatment outcomes. Experimental openings in speech bulbs have been used for simulating VPI in studies documenting changes in aerodynamic, acoustic and kinematics aspects of speech associated with the use of palatal prosthetic devices. The use of nasometry to document changes in speech associated with experimental openings in speech bulbs, however, has not been described in the literature. Objective This single-subject study investigated nasalance and nasality at the presence of experimental openings drilled through the speech bulb of a patient with HV. Material and Methods Nasometric recordings of the word "pato" were obtained under 4 velopharyngeal conditions: no-opening (control condition), no speech bulb, speech bulb with a 20 mm2 opening, and speech bulb with 30 mm2 opening. Five speech-language pathologists performed auditory-perceptual ratings while the subject read an oral passage under all conditions. Results Kruskal-Wallis test showed significant difference among conditions (p=0.0002), with Scheffé post hoc test indicating difference from the no-opening condition. Conclusion The changes in nasalance observed after drilling holes of known sizes in a speech bulb suggest that nasometry reflect changes in transfer of sound energy related to different sizes of velopharyngeal opening. PMID:22230996

  18. Sepsis from dropped clips at laparoscopic cholecystectomy

    International Nuclear Information System (INIS)

    We report seven patients in whom five dropped surgical clips and two gallstones were visualized in the peritoneal cavity, on radiological studies. In two, subphrenic abscesses and empyemas developed as a result of dropped clips into the peritoneal cavity during or following laparoscopic cholecystectomy. In one of these two, a clip was removed surgically from the site of an abscess. In two other patients dropped gallstones, and in three, dropped clips led to no complications. These were seen incidentally on studies done for other indications. Abdominal abscess secondary to dropped gallstones is a well-recognized complication of laparoscopic cholecystectomy (LC). We conclude that even though dropped surgical clips usually do not cause problems, they should be considered as a risk additional to other well-known causes of post-LC abdominal sepsis

  19. Pressure Drop Measurements on Distillation Columns

    Institute of Scientific and Technical Information of China (English)

    T.J. Cai; M.R. Resetarits

    2011-01-01

    Pressure drops are of major importance for distillation/absorption columns. This paper mainly discusses how to correctly measure, interpret and use pressure drop data. The possible causes of incorrect pressure drop measurements are studied including the effects of pressure tap dimensions, locations, and vapor condensation etc. The effect of the static head of vapor on the pressure drop data and column pressures is evaluated. Variations of sectional pressure drops along the column are investigated based on the experimental data obtained from commercial size distillation columns at Fractionation Research, Inc. (FRI). For a packed column, it is found that the spacing between the liquid distributor and the top of the bed affects the overall pressure drop measurements, which is confirmed by a fundamental fluid dynamics analysis.

  20. Sepsis from dropped clips at laparoscopic cholecystectomy

    Energy Technology Data Exchange (ETDEWEB)

    Hussain, Sarwat E-mail: sarwathussain@hotmail.com

    2001-12-01

    We report seven patients in whom five dropped surgical clips and two gallstones were visualized in the peritoneal cavity, on radiological studies. In two, subphrenic abscesses and empyemas developed as a result of dropped clips into the peritoneal cavity during or following laparoscopic cholecystectomy. In one of these two, a clip was removed surgically from the site of an abscess. In two other patients dropped gallstones, and in three, dropped clips led to no complications. These were seen incidentally on studies done for other indications. Abdominal abscess secondary to dropped gallstones is a well-recognized complication of laparoscopic cholecystectomy (LC). We conclude that even though dropped surgical clips usually do not cause problems, they should be considered as a risk additional to other well-known causes of post-LC abdominal sepsis.

  1. Effectiveness of septoplasty versus non-surgical management for nasal obstruction due to a deviated nasal septum in adults: study protocol for a randomized controlled trial

    NARCIS (Netherlands)

    Egmond, M.M.H.T. van; Rovers, M.M.; Hendriks, C.T.; Heerbeek, N. van

    2015-01-01

    BACKGROUND: Septoplasty, i.e., surgical correction of the deviated nasal septum, is the most common ear, nose and throat (ENT) operation in adults. Currently the main indication to perform septoplasty is nasal obstruction. However, the effectiveness of septoplasty for nasal obstruction in adults wit

  2. Condensation-induced jumping water drops

    OpenAIRE

    Narhe, R.D. (Ramchandra D.); Khandkar, M. D.; Shelke, P.B. (P. B.); Limaye, A. V.; Beysens, D.A. (Daniel A.)

    2009-01-01

    Water droplets can jump during vapor condensation on solid benzene near its melting point. This phenomenon, which can be viewed as a kind of micro scale steam engine, is studied experimentally and numerically. The latent heat of condensation transferred at the drop three phase contact line melts the substrate during a time proportional to R the drop radius . The wetting conditions change and a spontaneous jump of the drop results in random direction over length 1.5R, a phenomeno...

  3. Noncontact surface tension measurement by drop rotation

    OpenAIRE

    Rhim, Won-Kyu; Ishikawa, Takehiko

    2001-01-01

    Validity of the surface tension measurement technique that was proposed by Elleman et al. was experimentally verified. The technique was based on Brown and Scriven's work on the shape evolution of rotating drops. Molten tin and aluminum drops were levitated in high vacuum by the electrostatic levitator and rotated by applying a rotating magnetic field. This technique offers an alternative technique for those liquids where the drop oscillation technique cannot be used. As a demonstration, the ...

  4. Drops with non-circular footprints

    OpenAIRE

    Ravazzoli, Pablo D.; González, Alejandro G.; Diez, Javier A.

    2015-01-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. This type of drops is a consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to hysteresis effects of the contact angle since some parts of the contact line are wetting, while others are dewetting. Here, we obtain a peculiar drop shape from the rupture of a long liquid filament sitting ...

  5. Clinical analysis of sino-nasal lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kojya, Shizuo; Itokazu, Tetsuo; Shinhama, Akihiko; Matsumura, Jun; Maeda, Hiroyuki; Inamine, Tomohiro; Toita, Takafumi; Ogawa, Kazuhiko; Noda, Yutaka [Ryukyus Univ., Nishihara, Okinawa (Japan). Faculty of Medicine

    2000-01-01

    Forty cases with sino-nasal malignant lymphoma who were treated at the Department of Otorhinolaryngology, University of the Ryukyus, Faculty of Medicine from 1974 to 1996 are herein reviewed. The staging of these cases was made based on the Ann Arbor classification system and pathologically according to the Working Formulation (WF). In addition, the lesions showed polymorphism regarding the size of the tumor cells which could invade in an angiocentric pattern with various types of inflammatory cells and necrosis of the surrounding tissue was classified as polymorphic reticulosis (PR). Regarding the immunological phenotype, immunostaining was performed with MB-1, L-26 for B cell type and MT-1, UCHL-1 for T cell type. The survival rate was calculated based on the Kaplan Meier method. The results were as follows; The immunophenotypes were T cell type in 63%, including 8 cases of NK cell type and B cell in 29%. Seventy-five percent of all cases were classified as an intermediate stage based on the Working Formulation. The 5-year survival rates for all cases, consisting of T cell type cases, B cell type cases and PR type cases were 49%, 42%, 50% and 54%, respectively. Chemotherapy, including CHOP demonstrated good therapeutic results, but the cases with lymphoma in the high grade group could not be controlled by ordinary therapeutic regimens. A histology-specific treatment regimen for high grade lymphoma is thus needed. (author)

  6. Superheated water drops in hot oil

    OpenAIRE

    Soto, Enrique; Zenit, Roberto; Belmonte, Andrew

    2009-01-01

    Drops of water at room temperature were released in hot oil, which had a temperature higher than that of the boiling point of water. Initially, the drop temperature increases slowly mainly due to heat transfer diffusion; convective heat transfer is small because the motion takes place at a small Reynolds number. Once the drop reaches the bottom of the container, it sticks to the surface with a certain contact angle. Then, a part of the drop vaporizes: the nucleation point may appear at the wa...

  7. Rapid Drop Dynamics During Superhydrophobic Condensation

    Science.gov (United States)

    Zhang, Xiaodong; Boreyko, Jonathan; Chen, Chuan-Hua

    2008-11-01

    Rapid drop motion is observed on superhydrophobic surfaces during condensation; condensate drops with diameter of order 10 μm can move at above 100G and 0.1 m/s. When water vapor condenses on a horizontal superhydrophobic surface, condensate drops move in a seemingly random direction. The observed motion is attributed to the energy released through coalescence of neighboring condensate drops. A scaling analysis captured the initial acceleration and terminal velocity. Our work is a step forward in understanding the dynamics of superhydrophobic condensation occurring in both natural water-repellant plants and engineered dropwise condensers.

  8. Impact force of a falling drop

    Science.gov (United States)

    Soto, Dan; Clanet, Cristophe; Quere, David; Xavier Boutillon Collaboration

    2012-11-01

    Controlling droplet deposition is crucial in many industrial processes such as spraying pesticides on crops, inkjet printing or spray coating. Therefore, the dynamics of drop impacts have been extensively studied for more than one century. However, few literature describe the impacting force of a drop on a solid flat surface, although it might be a way to measure the size distribution of a collection of falling drops. We investigated experimentally how the instantaneous force at impact depends on impact velocity and drop radius. We also propose a new model to understand our observations. Physique et Mecanique des Milieux Heterogenes, CNRS, ESPCI, Paris France & Ladhyx, CNRS, Ecole Polytechnique, Palaiseau, France.

  9. Parametric resonance in acoustically levitated water drops

    Energy Technology Data Exchange (ETDEWEB)

    Shen, C.L.; Xie, W.J. [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China); Wei, B., E-mail: bbwei@nwpu.edu.c [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2010-05-10

    Liquid drops can be suspended in air with acoustic levitation method. When the sound pressure is periodically modulated, the levitated drop is usually forced into an axisymmetric oscillation. However, a transition from axisymmetric oscillation into sectorial oscillation occurs when the modulation frequency approaches some specific values. The frequency of the sectorial oscillation is almost exactly half of the modulation frequency. It is demonstrated that this transition is induced by the parametric resonance of levitated drop. The natural frequency of sectorial oscillation is found to decrease with the increase of drop distortion extent.

  10. Drop deformation by laser-pulse impact

    CERN Document Server

    Gelderblom, Hanneke; Klein, Alexander L; Bouwhuis, Wilco; Lohse, Detlef; Villermaux, Emmanuel; Snoeijer, Jacco H

    2015-01-01

    A free-falling absorbing liquid drop hit by a nanosecond laser-pulse experiences a strong recoil-pressure kick. As a consequence, the drop propels forward and deforms into a thin sheet which eventually fragments. We study how the drop deformation depends on the pulse shape and drop properties. We first derive the velocity field inside the drop on the timescale of the pressure pulse, when the drop is still spherical. This yields the kinetic-energy partition inside the drop, which precisely measures the deformation rate with respect to the propulsion rate, before surface tension comes into play. On the timescale where surface tension is important the drop has evolved into a thin sheet. Its expansion dynamics is described with a slender-slope model, which uses the impulsive energy-partition as an initial condition. Completed with boundary integral simulations, this two-stage model explains the entire drop dynamics and its dependance on the pulse shape: for a given propulsion, a tightly focused pulse results in a...

  11. Videographic Assessment of Glaucoma Drop Instillation

    Science.gov (United States)

    Castillejos, Armando; Kahook, Malik; Jimenez-Roman, Jesus; Gonzalez-Salinas, Roberto

    2015-01-01

    ABSTRACT Purpose: To assess the effect of patient education on videotaped topical instillation of artificial tear drops on subsequent topical instillation. Materials and methods: Forty-five patients, who had been using glaucoma drops for at least 6 months and with a best-corrected visual acuity of 20/100 or better, were studied. The patients were asked to instill an artificial tear drop using their accustomed technique while being video recorded. The patients viewed the recordings, and the errors in their drop instillation method were pointed out. This was followed by an educational session on proper drop instillation technique. After 30 minutes, patients were videotaped instilling drops to ascertain the effect of the educational session. The variables compared were: number of drops instilled, number of drops reaching the ocular surface, and the number of times the tip of the medication bottle touched the eye or ocular adnexa. Results: Before the instruction session, patients squeezed an average of 1.5 ± 0.9 drops from the bottle, and the average number of drops reaching the conjunctival fornix was 0.9 ± 0.7. The tip of the bottle touched the ocular adnexa in 29/45 (64.4%) patients. After the education session, the patients squeezed an average of 1.2 ± 0.5 drops and an average of 1.2 ± 0.4 drops reached the conjunctival fornix. The tip of the bottle touched the ocular adnexa in 13/45 (28.9%) patients. With proper instructions, the percentage of patients that instilled just one drop on the eye increased from 66 to 82%. Conclusion: A single educational session on the proper use of topical drops improves the successful instillation of eye drops. However, it was not determined whether the patients will retain the improved instillation technique for long-term or if the intervention results in only a short-term improvement. How to cite this article: Lazcano-Gomez G, Castillejos A, Kahook M, Jimenez-Roman J, Gonzalez-Salinas R. Video-graphic Assessment of Glaucoma

  12. Rotating Drops with Helicoidal Symmetry

    CERN Document Server

    Palmer, Bennett

    2014-01-01

    See http://youtu.be/Mf4IE8gWcJs for a YouTube video showing part of the results in this paper. We consider helicoidal immersions in the Euclidean space whose axis of symmetry is the z-axis that are solutions of the equation 2 H=\\Lambda_0-a 1/2 R^2 where H is the mean curvature of the surface, R is the distance form the point in the surface to the z-axis and a is a real number. We refer to these surfaces as helicoidal rotating drops. We prove the existence of properly immersed solutions that contain the z-axis. We also show the existence of several families of embedded examples. We describe the set of possible solutions and we show that most of these solutions are not properly immerse and are dense in the region bounded by two concentric cylinders. We show that all properly immersed solutions, besides being invariant under a one parameter helicoidal group, they are invariant under a cyclic group of rotations of the variables x and y. The second variation of energy for the volume constrained problem with Dirich...

  13. Nasal toxicity, carcinogenicity, and olfactory uptake of metals.

    Science.gov (United States)

    Sunderman, F W

    2001-01-01

    Occupational exposures to inhalation of certain metal dusts or aerosols can cause loss of olfactory acuity, atrophy of the nasal mucosa, mucosal ulcers, perforated nasal septum, or sinonasal cancer. Anosmia and hyposmia have been observed in workers exposed to Ni- or Cd-containing dusts in alkaline battery factories, nickel refineries, and cadmium industries. Ulcers of the nasal mucosa and perforated nasal septum have been reported in workers exposed to Cr(VI) in chromate production and chrome plating, or to As(III) in arsenic smelters. Atrophy of the olfactory epithelium has been observed in rodents following inhalation of NiSO4 or alphaNi3S2. Cancers of the nose and nasal sinuses have been reported in workers exposed to Ni compounds in nickel refining, cutlery factories, and alkaline battery manufacture, or to Cr(VI) in chromate production and chrome plating. In animals, several metals (eg, Al, Cd, Co, Hg, Mn, Ni, Zn) have been shown to pass via olfactory receptor neurons from the nasal lumen through the cribriform plate to the olfactory bulb. Some metals (eg, Mn, Ni, Zn) can cross synapses in the olfactory bulb and migrate via secondary olfactory neurons to distant nuclei of the brain. After nasal instillation of a metal-containing solution, transport of the metal via olfactory axons can occur rapidly, within hours or a few days (eg, Mn), or slowly over days or weeks (eg, Ni). The olfactory bulb tends to accumulate certain metals (eg, Al, Bi, Cu, Mn, Zn) with greater avidity than other regions of the brain. The molecular mechanisms responsible for metal translocation in olfactory neurons and deposition in the olfactory bulb are unclear, but complexation by metal-binding molecules such as carnosine (beta-alanyl-L-histidine) may be involved. PMID:11314863

  14. MEASUREMENT OF NASAL FIGURE BY MAGNETIC RESONANCE IMAGING

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To get the basic data of nasal figure of the Han nationality individuals in Xi'an area and provide for junsprudence and the reconstruction of skull. Methods Nasal height, length, depth and breadth of 313cases in Xi'an area, which had different age and sex, were measured by magnetic resonance imaging (MRI). Results Image of MRI could clearly show the figure of nose and the position we selected were correct and accuracy. The specific data were: Nasal length (male:34. 47±4.29 ~52.20±3.47, female:33. 11±3.33~46. 94±3.83); Nasal height(male: 39.22±3.68~59.49±2.30, female: 33.89±3.95~51.75±3.68); Nasal depth(male: 11.89±1.76~16.68±2.48, female: 10.69±1. 81~16.46±2.04);Nasal breadth(male: 33. 09±3. 83~42. 49±2.72,female:32.00±1.94~38. 86±2.61). So the results were credible. Conclusion The nasal figure of individuals in Xi'an area is different as their different age and sex. It promotes that the influence factors of age and sex must be considered in the facial reconstruction and medico legally reconstructing skull.

  15. The effects of naris occlusion on mouse nasal turbinate development.

    Science.gov (United States)

    Coppola, David M; Craven, Brent A; Seeger, Johannes; Weiler, Elke

    2014-06-15

    Unilateral naris occlusion, a standard method for causing odor deprivation, also alters airflow on both sides of the nasal cavity. We reasoned that manipulating airflow by occlusion could affect nasal turbinate development given the ubiquitous role of environmental stimuli in ontogenesis. To test this hypothesis, newborn mice received unilateral occlusion or sham surgery and were allowed to reach adulthood. Morphological measurements were then made of paraffin sections of the whole nasal cavity. Occlusion significantly affected the size, shape and position of turbinates. In particular, the nasoturbinate, the focus of our quantitative analysis, had a more delicate appearance on the occluded side relative to the open side. Occlusion also caused an increase in the width of the dorsal meatus within the non-occluded and occluded nasal fossae, compared with controls, and the position of most turbinates was altered. These results suggest that a mechanical stimulus from respiratory airflow is necessary for the normal morphological development of turbinates. To explore this idea, we estimated the mechanical forces on turbinates caused by airflow during normal respiration that would be absent as a result of occlusion. Magnetic resonance imaging scans were used to construct a three-dimensional model of the mouse nasal cavity that provided the input for a computational fluid dynamics simulation of nasal airflow. The simulation revealed maximum shear stress values for the walls of turbinates in the 1 Pa range, a magnitude that causes remodeling in other biological tissues. These observations raise the intriguing possibility that nasal turbinates develop partly under the control of respiratory mechanical forces.

  16. Many Drops Make a Lake

    Directory of Open Access Journals (Sweden)

    Chaitanya S. Mudgal

    2014-03-01

    greater knowledge, better skills and disseminate this knowledge through this journal to influence as many physicians and their patients as possible. They have taken the knowledge of their teachers, recognized their giants and are now poised to see further than ever before. My grandmother often used to quote to me a proverb from India, which when translated literally means “Many drops make a lake”. I cannot help but be amazed by the striking similarities between the words of Newton and this Indian saying. Therefore, while it may seem intuitive, I think it must be stated that it is vital for the betterment of all our patients that we recognize our own personal lakes to put our drops of knowledge into. More important is that we recognize that it is incumbent upon each and every one of us to contribute to our collective lakes of knowledge such as ABJS. And finally and perhaps most importantly we need to be utterly cognizant of never letting such lakes of knowledge run dry.... ever.

  17. 49 CFR 178.603 - Drop test.

    Science.gov (United States)

    2010-10-01

    ... qualification of all packaging design types and performed periodically as specified in § 178.601(e). For other than flat drops, the center of gravity of the test packaging must be vertically over the point of... result in failure of the packaging must be used. The number of drops required and the...

  18. Electrical Excitation of Water Drops in Oil

    OpenAIRE

    Penne, Torstein Eidsnes

    2015-01-01

    Water drops in oil are excited by the use of electric fields. This thesis looks at the behavior of water drops subjected to different fields. These fields vary in shape and strength. The motivation behind is separation of oil and water after oil extraction with water injection, by using electric fields for electrocoalescence.

  19. Mixing in colliding, ultrasonically levitated drops.

    Science.gov (United States)

    Chainani, Edward T; Choi, Woo-Hyuck; Ngo, Khanh T; Scheeline, Alexander

    2014-02-18

    Lab-in-a-drop, using ultrasonic levitation, has been actively investigated for the last two decades. Benefits include lack of contact between solutions and an apparatus and a lack of sample cross-contamination. Understanding and controlling mixing in the levitated drop is necessary for using an acoustically levitated drop as a microreactor, particularly for studying kinetics. A pulsed electrostatic delivery system enables addition and mixing of a desired-volume droplet with the levitated drop. Measurement of mixing kinetics is obtained by high-speed video monitoring of a titration reaction. Drop heterogeneity is visualized as 370 nl of 0.25 M KOH (pH: 13.4) was added to 3.7 μL of 0.058 M HCl (pH: 1.24). Spontaneous mixing time is about 2 s. Following droplet impact, the mixed drop orbits the levitator axis at about 5 Hz during homogenization. The video's green channel (maximum response near 540 nm) shows the color change due to phenolphthalein absorption. While mixing is at least an order of magnitude faster in the levitated drop compared with three-dimensional diffusion, modulation of the acoustic waveform near the surface acoustic wave resonance frequency of the levitated drop does not substantially reduce mixing time. PMID:24460103

  20. Total Site Heat Integration Considering Pressure Drops

    Directory of Open Access Journals (Sweden)

    Kew Hong Chew

    2015-02-01

    Full Text Available Pressure drop is an important consideration in Total Site Heat Integration (TSHI. This is due to the typically large distances between the different plants and the flow across plant elevations and equipment, including heat exchangers. Failure to consider pressure drop during utility targeting and heat exchanger network (HEN synthesis may, at best, lead to optimistic energy targets, and at worst, an inoperable system if the pumps or compressors cannot overcome the actual pressure drop. Most studies have addressed the pressure drop factor in terms of pumping cost, forbidden matches or allowable pressure drop constraints in the optimisation of HEN. This study looks at the implication of pressure drop in the context of a Total Site. The graphical Pinch-based TSHI methodology is extended to consider the pressure drop factor during the minimum energy requirement (MER targeting stage. The improved methodology provides a more realistic estimation of the MER targets and valuable insights for the implementation of the TSHI design. In the case study, when pressure drop in the steam distribution networks is considered, the heating and cooling duties increase by 14.5% and 4.5%.

  1. Temperature Effect on Photovoltaic Modules Power Drop

    Directory of Open Access Journals (Sweden)

    Qais Mohammed Aish

    2015-06-01

    Full Text Available In order to determine what type of photovoltaic solar module could best be used in a thermoelectric photovoltaic power generation. Changing in powers due to higher temperatures (25oC, 35oC, and 45oC have been done for three types of solar modules: monocrystalline , polycrystalline, and copper indium gallium (di selenide (CIGS. The Prova 200 solar panel analyzer is used for the professional testing of three solar modules at different ambient temperatures; 25oC, 35oC, and 45oC and solar radiation range 100-1000 W/m2. Copper indium gallium (di selenide module has the lowest power drop (with the average percentage power drop 0.38%/oC while monocrystalline module has the highest power drop (with the average percentage power drop 0.54%/oC, while polycrystalline module has a percentage power drop of 0.49%/oC.

  2. CPAS Preflight Drop Test Analysis Process

    Science.gov (United States)

    Englert, Megan E.; Bledsoe, Kristin J.; Romero, Leah M.

    2015-01-01

    Throughout the Capsule Parachute Assembly System (CPAS) drop test program, the CPAS Analysis Team has developed a simulation and analysis process to support drop test planning and execution. This process includes multiple phases focused on developing test simulations and communicating results to all groups involved in the drop test. CPAS Engineering Development Unit (EDU) series drop test planning begins with the development of a basic operational concept for each test. Trajectory simulation tools include the Flight Analysis and Simulation Tool (FAST) for single bodies, and the Automatic Dynamic Analysis of Mechanical Systems (ADAMS) simulation for the mated vehicle. Results are communicated to the team at the Test Configuration Review (TCR) and Test Readiness Review (TRR), as well as at Analysis Integrated Product Team (IPT) meetings in earlier and intermediate phases of the pre-test planning. The ability to plan and communicate efficiently with rapidly changing objectives and tight schedule constraints is a necessity for safe and successful drop tests.

  3. Ferrofluid drops in rotating magnetic fields

    CERN Document Server

    Lebedev, A V; Morozov, K I; Bauke, H

    2003-01-01

    Drops of a ferrofluid floating in a non-magnetic liquid of the same density and spun by a rotating magnetic field are investigated experimentally and theoretically. The parameters for the experiment are chosen such that different stationary drop shapes including non-axis-symmetric configurations could be observed. Within an approximate theoretical analysis the character of the occurring shape bifurcations, the different stationary drop forms, as well as the slow rotational motion of the drop is investigated. The results are in qualitative, and often quantitative agreement, with the experimental findings. It is also shown that a small eccentricity of the rotating field may have a substantial impact on the rotational motion of the drop.

  4. Effects of nasal corticosteroids on boosts of systemic allergen-specific IgE production induced by nasal allergen exposure.

    Directory of Open Access Journals (Sweden)

    Cornelia Egger

    Full Text Available Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear.Here we aimed to determine in a double-blind, placebo-controlled study whether therapeutic doses of an INCS preparation, i.e., nasal fluticasone propionate, have effects on boosts of allergen-specific IgE following nasal allergen exposure.Subjects (n = 48 suffering from grass and birch pollen allergy were treated with daily fluticasone propionate or placebo nasal spray for four weeks. After two weeks of treatment, subjects underwent nasal provocation with either birch pollen allergen Bet v 1 or grass pollen allergen Phl p 5. Bet v 1 and Phl p 5-specific IgE, IgG1-4, IgM and IgA levels were measured in serum samples obtained at the time of provocation and one, two, four, six and eight weeks thereafter.Nasal allergen provocation induced a median increase to 141.1% of serum IgE levels to allergens used for provocation but not to control allergens 4 weeks after provocation. There were no significant differences regarding the boosts of allergen-specific IgE between INCS- and placebo-treated subjects.In conclusion, the application of fluticasone propionate had no significant effects on the boosts of systemic allergen-specific IgE production following nasal allergen exposure.http://clinicaltrials.gov/NCT00755066.

  5. Does gently clearing the nasal passage affect odor identification?

    Directory of Open Access Journals (Sweden)

    Mitchell G. Spring

    2014-12-01

    Full Text Available Identifying scents in a wine’s bouquet is considered one of the most important steps in the process of wine tasting. An individual’s ability to successfully do this is dependent on the sense of smell; thus, altering the nasal microenvironment could have a powerful effect on the wine tasting experience. In the present study, we examined olfactory performance in healthy participants who cleared their nasal cavity before odorant presentations. Fifty undergraduate participants were assessed with a standardized test of olfaction requiring the recognition of a battery of odors. Half of these participants cleared mucus from their nasal cavities (by gently blowing their noses prior to the assessment. No difference was found in performance between those who cleared their nasal passages and those who did not. Further, data were not different than known population data from the test. These data suggest that gently clearing the nasal cavity before presentation of odorants bears no effect on the ability to perceive those odor qualities.

  6. The effect of rapid maxillary expansion on nasal airway resistance.

    Science.gov (United States)

    White, B C; Woodside, D G; Cole, P

    1989-06-01

    The purpose of this investigation was to provide quantitative data describing the effects of rapid palatal expansion on nasal airway resistance. Rapid palatal expansion is an orthodontic procedure which is commonly used to widen the maxilla to correct maxillary narrowing resulting in the orthodontic abnormality of crossbite and to provide more space for alignment of crowded teeth. Recordings of nasal airway resistance were taken prior to expansion, immediately after expansion (approximately one month), after a retention period of approximately 4 months and approximately one year after initiation of treatment. Findings indicate an average reduction in nasal airway resistance of 48.7 per cent which was statistically significant at the 0.005 level. The reduction also appeared stable throughout the post treatment observation period (maximum one year) as each series of readings was statistically significantly lower than the initial reading, but not significantly different from each other. Reduction of nasal airway resistance was highly correlated to the initial nasal resistance level prior to rapid maxillary expansion. Those individuals with the greater initial resistance tended to have greater reductions in airway resistance following the expansion.

  7. Optimization of Thermoreversible In Situ Nasal Gel of Timolol Maleate

    Directory of Open Access Journals (Sweden)

    Swati Jagdale

    2016-01-01

    Full Text Available Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. Timolol maleate is a beta blocker used primarily in the treatment of hypertension. Drug undergoes extensive hepatic first-pass metabolism (80%. The drug has half-life of 4 hrs. Oral bioavailability of timolol maleate is 61%. The aim of the present study was to optimize controlled release in situ nasal delivery for timolol maleate. HPMC and Poloxamer 407 were selected as polymer in formulation of thermoreversible in situ nasal gel. Optimization was carried out using 32 factorial design. It was observed that formulations f1 and f4 revealed the highest % drug release, that is, 93.57% and 91.66%, respectively. Factorial design study indicated that the drug release and viscosity were most significant dependent factors. Ex vivo diffusion study through nasal mucosa indicated 67.26 ± 2.10% and 61.07 ± 2.49% drug release for f1 and f4 formulations. f1 was the optimized batch. This batch thus can act as a potential nasal delivery with enhanced bioavailability for the drug.

  8. Infection in the Nasal Tip Caused by Acellular Dermal Matrix.

    Science.gov (United States)

    Lee, Kun Hee

    2015-12-01

    A 19-year-old female patient visited our clinic for rhinoplasty. She complained about her low take-off point, which was apparent in profile view, and wanted slight tip projection. She refused additional cartilage harvesting from ears or ribs but consented to the use of homologous tissue, including acellular dermal matrix, for her dorsum and tip. Septoturbinoplasty was performed, and only a very small amount of septal cartilage could be harvested. It was used as both the columellar strut and the alar rim graft. Nasal dorsum and tip were augmented with acellular dermal matrix. Three months postoperatively, she experienced a few episodes of edema and redness on her nasal tip, followed by pus exudation from the nasal skin. Six months postoperatively, she underwent revision rhinoplasty for removal of inflamed grafts, and onlay tip graft with homologous rib cartilage was performed. Nasal dorsum or tip grafts are an integral part of Asian rhinoplasty. Autogenous tissue is the gold standard for grafting materials. However, the limited availability of autogenous tissue and the preference of patients and surgeons for artificial surgical implants make Asian rhinoplasty challenging. Unavailability of autogenous cartilage and patient refusal of artificial implants led to the use of acellular dermal matrix (ADM) in the nasal dorsum and tip for this case. This is the first report of postoperative complication because of infection rather than absorption after ADM use. PMID:26894006

  9. Actual therapeutic management of allergic and hyperreactive nasal disorders

    Directory of Open Access Journals (Sweden)

    Rudack, Claudia

    2004-12-01

    Full Text Available Allergic rhinitis (AR and hyperractive disorders of the upper airways, depending upon the type of releasing stimuli, are defined as nasal hyperreactivity, for example in the case of AR, or as non-specific nasal hyperreactivity and as idiopathic rhinitis (IR (synonyms frequently used in the past: non-specific nasal hyperreactivity; vasomotor rhinitis in the case of non-characterised stimuli.An early and professional therapy of allergic disorders of the upper airways is of immense importance as allergic rhinitis is detected in comorbidities such as asthma and rhino sinusitis. The therapeutic concept is influenced by new and further developments in pharmacological substance classes such as antihistamines and glucocorticosteroids. Specific immune therapy, the only causal therapy for AR, has been reviewed over the past few years in respect of the type and pattern of application. However, to date no firm recommendations on oral, sublingual and /or nasal immune therapy have yet been drawn up based on investigations of these modifications.Therapeutic management of IR is aimed at a symptom-oriented therapy of nasal hyperactivity as etiological factors relating to this form of rhinitis are not yet sufficiently known. Drug groups such as mast cell stabilizers, systemic and topic antihistamines, topic and systemic glucocorticosteroids, ipatroium bromide and alpha symphatomimetics belong to the spectrum of the therapeutics employed.

  10. Shape of the human nasal cavity promotes retronasal smell

    Science.gov (United States)

    Trastour, Sophie; Melchionna, Simone; Mishra, Shruti; Zwicker, David; Lieberman, Daniel E.; Kaxiras, Efthimios; Brenner, Michael P.

    2015-11-01

    Humans are exceptionally good at perceiving the flavor of food. Flavor includes sensory input from taste receptors but is dominated by olfactory (smell) receptors. To smell food while eating, odors must be transported to the nasal cavity during exhalation. Olfactory performance of this retronasal route depends, among other factors, on the position of the olfactory receptors and the shape of the nasal cavity. One biological hypothesis is that the derived configuration of the human nasal cavity has resulted in a greater capacity for retronasal smell, hence enhanced flavor perception. We here study the air flow and resulting odor deposition as a function of the nasal geometry and the parameters of exhalation. We perform computational fluid dynamics simulations in realistic geometries obtained from CT scans of humans. Using the resulting flow fields, we then study the deposition of tracer particles in the nasal cavity. Additionally, we derive scaling laws for the odor deposition rate as a function of flow parameters and geometry using boundary layer theory. These results allow us to assess which changes in the evolution of the human nose led to significant improvements of retronasal smell.

  11. Risk of contamination of nasal sprays in otolaryngologic practice

    Directory of Open Access Journals (Sweden)

    Akkuzu Babur

    2007-03-01

    Full Text Available Abstract Background Reusable nasal-spray devices are frequently used in otolaryngologic examinations, and there is an increasing concern about the risk of cross-contamination from these devices. The aim of our study was to determine, by means of microbiologic analysis, the safety of a positive-displacement or pump-type atomizer after multiple uses. Methods A reusable nasal spray bottle, pump, and tips were used in the nasal physical examination of 282 patients admitted to a tertiary otolaryngology clinic. The effectiveness of 2 different methods of prophylaxis against microbiologic contamination (the use of protective punched caps or rinsing the bottle tip with alcohol was compared with that of a control procedure. Results Although there was no statistically significant difference in positive culture rates among the types of nasal spray bottles tested, methicillin-resistant coagulase-negative staphylococci were isolated in 4 of 198 cultures. Conclusion Given these findings, we concluded that additional precautions (such as the use of an autoclave between sprays, disposable tips, or disposable devices are warranted to avoid interpatient cross-contamination from a reusable nasal spray device.

  12. Condensation on surface energy gradient shifts drop size distribution toward small drops.

    Science.gov (United States)

    Macner, Ashley M; Daniel, Susan; Steen, Paul H

    2014-02-25

    During dropwise condensation from vapor onto a cooled surface, distributions of drops evolve by nucleation, growth, and coalescence. Drop surface coverage dictates the heat transfer characteristics and depends on both drop size and number of drops present on the surface at any given time. Thus, manipulating drop distributions is crucial to maximizing heat transfer. On earth, manipulation is achieved with gravity. However, in applications with small length scales or in low gravity environments, other methods of removal, such as a surface energy gradient, are required. This study examines how chemical modification of a cooled surface affects drop growth and coalescence, which in turn influences how a population of drops evolves. Steam is condensed onto a horizontally oriented surface that has been treated by silanization to deliver either a spatially uniform contact angle (hydrophilic, hydrophobic) or a continuous radial gradient of contact angles (hydrophobic to hydrophilic). The time evolution of number density and associated drop size distributions are measured. For a uniform surface, the shape of the drop size distribution is unique and can be used to identify the progress of condensation. In contrast, the drop size distribution for a gradient surface, relative to a uniform surface, shifts toward a population of small drops. The frequent sweeping of drops truncates maturation of the first generation of large drops and locks the distribution shape at the initial distribution. The absence of a shape change indicates that dropwise condensation has reached a steady state. Previous reports of heat transfer enhancement on chemical gradient surfaces can be explained by this shift toward smaller drops, from which the high heat transfer coefficients in dropwise condensation are attributed to. Terrestrial applications using gravity as the primary removal mechanism also stand to benefit from inclusion of gradient surfaces because the critical threshold size required for

  13. Formulation and Evaluation of Nasal Niosomal in situ Gels of Loratadine

    Directory of Open Access Journals (Sweden)

    Vyshnavi. V

    2015-01-01

    Full Text Available Loratadine is an antihistaminic drug, used in the treatment of allergic inflammation. Poor bioavailability of the drug from conventional dosage forms is especially attributable to mucociliary clearance and transient residence time. These problems can be reduced by the employment of niosomal in situ gelling system. In situ gelling of niosomal drops was developed to maintain the drug localization for extended period of time. The niosomal in situ gel formulation was transformed into gel once it is instilled into the nasal cavity. Niosomes were formulated using various surfactants (span 20, 40, 60 and 80 in different ratios using thin film hydration technique. Niosomes were evaluated for particle size, drug entrapment efficiency and in-vitro drug release. Niosomes prepared using cholesterol and span 60 in the ratio 1:1 (F3 showed higher entrapment efficiency (94.87% and in-vitro drug release (59.90% was optimized. The optimized niosomes were developed into in situ gel (pH induced and thermoreversible. The gels were evaluated for gelling capability, pH, viscosity, drug content and in-vitro drug release. Ex-vivo permeation was performed for optimized in situ gels (G2 and T5. The flux (Jss and Permeability Coefficient (Kp was found to be higher for G2. Hence niosomal in situ gelling system may have its potential applications than the conventional nasal formulations and to improve the bioavailability of the drug through its longer residence time and ability to sustain drug release with minimal loss of drug.

  14. Testing gene therapy vectors in human primary nasal epithelial cultures.

    Science.gov (United States)

    Cao, Huibi; Ouyang, Hong; Ip, Wan; Du, Kai; Duan, Wenming; Avolio, Julie; Wu, Jing; Duan, Cathleen; Yeger, Herman; Bear, Christine E; Gonska, Tanja; Hu, Jim; Moraes, Theo J

    2015-01-01

    Cystic fibrosis (CF) results from mutations in the CF transmembrane conductance regulator (CFTR) gene, which codes for a chloride/bicarbonate channel in the apical epithelial membranes. CFTR dysfunction results in a multisystem disease including the development of life limiting lung disease. The possibility of a cure for CF by replacing defective CFTR has led to different approaches for CF gene therapy; all of which ultimately have to be tested in preclinical model systems. Primary human nasal epithelial cultures (HNECs) derived from nasal turbinate brushing were used to test the efficiency of a helper-dependent adenoviral (HD-Ad) vector expressing CFTR. HD-Ad-CFTR transduction resulted in functional expression of CFTR at the apical membrane in nasal epithelial cells obtained from CF patients. These results suggest that HNECs can be used for preclinical testing of gene therapy vectors in CF. PMID:26730394

  15. Nasal reflexes: implications for exercise, breathing, and sex.

    Science.gov (United States)

    Baraniuk, James N; Merck, Samantha J

    2008-04-01

    Nasal patency, with both congestion and decongestion, is affected in a wide variety of reflexes. Stimuli leading to nasal reflexes include exercise; alterations of body position, pressure, and temperature; neurologic syndromes; and dentistry. As anticipated, the vagal and trigeminal systems are closely integrated through nasobronchial and bronchonasal reflexes. However, perhaps of greater pathophysiologic importance are the naso-hypopharyngeal-laryngeal reflexes that become aggravated during sinusitis. None other than Sigmund Freud saw deeply beyond the facial adornment and recognized the deeper sexual tensions that can regulate nasal functions and psychoanalytical status. Wine, women, and song are linked with airflow through the nose-the nose, which by any other name would still smell as sweetly. PMID:18417057

  16. Leidenfrost drops on a heated liquid pool

    CERN Document Server

    Maquet, Laurent; Darbois-Texier, Baptiste; Brandenbourger, Martin; Rednikov, Alexey; Colinet, Pierre; Dorbolo, Stéphane

    2016-01-01

    We show that a volatile liquid drop placed at the surface of a non-volatile liquid pool warmer than the boiling point of the drop can experience a Leidenfrost effect even for vanishingly small superheats. Such an observation points to the importance of the substrate roughness, negligible in the case considered here, in determining the threshold Leidenfrost temperature. A theoretical model based on the one proposed by Sobac et al. [Phys. Rev. E 90, 053011 (2014)] is developed in order to rationalize the experimental data. The shapes of the drop and of the substrate are analyzed. The model notably provides scalings for the vapor film thickness. For small drops, these scalings appear to be identical to the case of a Leidenfrost drop on a solid substrate. For large drops, in contrast, they are different and no evidence of chimney formation has been observed either experimentally or theoretically in the range of drop sizes considered in this study. Concerning the evaporation dynamics, the radius is shown to decrea...

  17. Superheated water drops in hot oil

    CERN Document Server

    Soto, Enrique; Belmonte, Andrew

    2009-01-01

    Drops of water at room temperature were released in hot oil, which had a temperature higher than that of the boiling point of water. Initially, the drop temperature increases slowly mainly due to heat transfer diffusion; convective heat transfer is small because the motion takes place at a small Reynolds number. Once the drop reaches the bottom of the container, it sticks to the surface with a certain contact angle. Then, a part of the drop vaporizes: the nucleation point may appear at the wall, the interface or the bulk of the drop. The vapor expands inside the drop and deforms its interface. The way in which the vapor expands, either smooth or violent, depends on the location of the nucleation point and oil temperature. Furthermore, for temperatures close to the boiling point of water, the drops are stable (overheated); the vaporization does not occur spontaneously but it may be triggered with an external perturbation. In this case the growth of the vapor bubble is rather violent. Many visualization for dif...

  18. Drop impact splashing and air entrapment

    KAUST Repository

    Thoraval, Marie-Jean

    2013-03-01

    Drop impact is a canonical problem in fluid mechanics, with numerous applications in industrial as well as natural phenomena. The extremely simple initial configuration of the experiment can produce a very large variety of fast and complex dynamics. Scientific progress was made in parallel with major improvements in imaging and computational technologies. Most recently, high-speed imaging video cameras have opened the exploration of new phenomena occurring at the micro-second scale, and parallel computing allowed realistic direct numerical simulations of drop impacts. We combine these tools to bring a new understanding of two fundamental aspects of drop impacts: splashing and air entrapment. The early dynamics of a drop impacting on a liquid pool at high velocity produces an ejecta sheet, emerging horizontally in the neck between the drop and the pool. We show how the interaction of this thin liquid sheet with the air, the drop or the pool, can produce micro-droplets and bubble rings. Then we detail how the breakup of the air film stretched between the drop and the pool for lower impact velocities can produce a myriad of micro-bubbles.

  19. Conically shaped drops in electric fields

    Science.gov (United States)

    Stone, Howard A.; Brenner, Michael P.; Lister, John R.

    1996-11-01

    When an electric field is applied to a dielectric liquid containing a suspended immiscible fluid drop, the drop deforms into a prolate ellipsoidal shape. Above a critical field strength the drop develops conical ends, as first observed by Zeleny [Phys. Rev. 10, 1 (1917)] and Wilson & Taylor [Proc. Camb. Phil. Soc. 22, 728 (1925)] for, respectively, the case of conducting drops and soap films in air. The case of two dielectric liquids was studied recently using a slender drop approximation by Li, Halsey & Lobkovsky [Europhys. Lett 27, 575 (1994)]. In this presentation we further develop the slender body approximation to obtain coupled ordinary differential equations for the electric field and the drop shape. Analytical formulae are derived which approximately give the cone angle as a function of the dielectric constant ratio between the two fluids, and the minimum applied electric field at which conical tips first form as a function of the dielectric constant ratio. Finally, drops shapes are calculated numerically and compared with the common prolate shape assumption.

  20. Terminal Effect of Drop Coalescence on Single Drop Mass Transfer Measurements and Its Minimization

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    For the mass transfer to single drops during the stage of steady buoyancy-driven motion, experimental measurement is complicated with the terminal effect of additional mass transfer during drop formation and coa lescence at the drop collector. Analysis reveals that consistent operating conditions and experimental procedure are of critical significance for minimizing the terminal effect of drop coalescence on the accuracy of mass transfer measurements. The novel design of a totally-closed extraction column is proposed for this purpose, which guaran tees that the volumetric rate of drop phase injection is exactly equal to that of withdrawal of drops. Tests in two extraction systems demonstrate that the experimental repeatability is improved greatly and the terminal effect of mass transfer during drop coalescence is brought well under control.

  1. Nasoendotracheal tube obstruction by a nasal polyp in emergency oral surgery: a case report

    OpenAIRE

    Milic Morena; Goranovic Tatjana; Knezevic Predrag

    2007-01-01

    Abstract Nasal polyps can make nasoendotracheal intubation difficult. We present a case of complete obstruction of a nasoendotracheal tube by a nasal polyp during a blind nasoendotracheal intubation in emergency oral surgery.

  2. The use of a camera-enabled mobile phone to triage patients with nasal bone injuries.

    LENUS (Irish Health Repository)

    Barghouthi, Taleb

    2012-03-01

    To identify the accuracy of a camera-enabled mobile phone in assessing patients with nasal bone injuries and to determine if treatment in the form of manipulation of the nasal bones and therefore outpatient attendance was necessary.

  3. Nasal polyps with metaplastic ossification: CT and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yi Kyung; Kim, Hyung-Jin; Kim, Eunhee; Kim, Sung Tae [Sungkyunkwan University School of Medicine, Department of Radiology, Samsung Medical Center, Seoul (Korea, Republic of); Kim, Jinna [Yonsei University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Chung, Seung-Kyu [Sungkyunkwan University School of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Seoul (Korea, Republic of); Ko, Young-Hyeh [Sungkyunkwan University School of Medicine, Department of Pathology, Samsung Medical Center, Seoul (Korea, Republic of)

    2010-12-15

    Metaplastic ossification is a rare event in nasal polyps. The purpose of this study was to review the computed tomography (CT) and magnetic resonance (MR) imaging findings of nasal polyps with metaplastic ossification. CT (n = 5) and MR (n = 3) images of five patients (four men and one woman; mean age, 59 years) with surgically proven nasal polyp with metaplastic ossification were retrospectively reviewed. The location and morphologic characteristics of metaplastic ossification were documented as well. All lesions were seen as lobulated (n = 3), ovoid (n = 1), or dumbbell-shaped (n = 1) benign-looking masses with a mean size of 3.7 cm (range, 2.4-6.5 cm), located unilaterally in the posterior nasal cavity and nasopharynx (n = 2), posterior nasoethmoidal tract (n = 2), and maxillary sinus and nasal cavity (n = 1). Compared with the brain stem, the soft tissue components of all lesions demonstrated isoattenuation on precontrast CT scans, slight hypointensity on T1-weighted MR images, and hyperintensity on T2-weighted MR images. On contrast-enhanced MR images, heterogeneous enhancement with marked peripheral enhancement was seen in two and homogeneous moderate enhancement in one. All lesions contained centrally located radiodense materials on CT scans, the shape of which was multiple clustered in three, single nodular in one, and single large lobulated in one. Although rare, metaplastic ossification can occur within nasal polyps. The possibility of its diagnosis may be raised when one sees a benign-looking sinonasal mass with centrally located radiodense materials on CT scans. MR imaging may be useful when mycetoma or inverted papilloma cannot be ruled out on CT scans. (orig.)

  4. Detecting Nasal Vowels in Speech Interfaces Based on Surface Electromyography.

    Directory of Open Access Journals (Sweden)

    João Freitas

    Full Text Available Nasality is a very important characteristic of several languages, European Portuguese being one of them. This paper addresses the challenge of nasality detection in surface electromyography (EMG based speech interfaces. We explore the existence of useful information about the velum movement and also assess if muscles deeper down in the face and neck region can be measured using surface electrodes, and the best electrode location to do so. The procedure we adopted uses Real-Time Magnetic Resonance Imaging (RT-MRI, collected from a set of speakers, providing a method to interpret EMG data. By ensuring compatible data recording conditions, and proper time alignment between the EMG and the RT-MRI data, we are able to accurately estimate the time when the velum moves and the type of movement when a nasal vowel occurs. The combination of these two sources revealed interesting and distinct characteristics in the EMG signal when a nasal vowel is uttered, which motivated a classification experiment. Overall results of this experiment provide evidence that it is possible to detect velum movement using sensors positioned below the ear, between mastoid process and the mandible, in the upper neck region. In a frame-based classification scenario, error rates as low as 32.5% for all speakers and 23.4% for the best speaker have been achieved, for nasal vowel detection. This outcome stands as an encouraging result, fostering the grounds for deeper exploration of the proposed approach as a promising route to the development of an EMG-based speech interface for languages with strong nasal characteristics.

  5. Detecting Nasal Vowels in Speech Interfaces Based on Surface Electromyography.

    Science.gov (United States)

    Freitas, João; Teixeira, António; Silva, Samuel; Oliveira, Catarina; Dias, Miguel Sales

    2015-01-01

    Nasality is a very important characteristic of several languages, European Portuguese being one of them. This paper addresses the challenge of nasality detection in surface electromyography (EMG) based speech interfaces. We explore the existence of useful information about the velum movement and also assess if muscles deeper down in the face and neck region can be measured using surface electrodes, and the best electrode location to do so. The procedure we adopted uses Real-Time Magnetic Resonance Imaging (RT-MRI), collected from a set of speakers, providing a method to interpret EMG data. By ensuring compatible data recording conditions, and proper time alignment between the EMG and the RT-MRI data, we are able to accurately estimate the time when the velum moves and the type of movement when a nasal vowel occurs. The combination of these two sources revealed interesting and distinct characteristics in the EMG signal when a nasal vowel is uttered, which motivated a classification experiment. Overall results of this experiment provide evidence that it is possible to detect velum movement using sensors positioned below the ear, between mastoid process and the mandible, in the upper neck region. In a frame-based classification scenario, error rates as low as 32.5% for all speakers and 23.4% for the best speaker have been achieved, for nasal vowel detection. This outcome stands as an encouraging result, fostering the grounds for deeper exploration of the proposed approach as a promising route to the development of an EMG-based speech interface for languages with strong nasal characteristics.

  6. New Hydrodynamic Mechanism for Drop Coarsening

    CERN Document Server

    Nikolayev, Vadim; Guenoun, Patrick

    2016-01-01

    We discuss a new mechanism of drop coarsening due to coalescence only, which describes the late stages of phase separation in fluids. Depending on the volume fraction of the minority phase, we identify two different regimes of growth, where the drops are interconnected and their characteristic size grows linearly with time, and where the spherical drops are disconnected and the growth follows (time) 1/3. The transition between the two regimes is sharp and occurs at a well defined volume fraction of order 30%.

  7. Deviation of viscous drops at chemical steps

    CERN Document Server

    Semprebon, Ciro; Filippi, Daniele; Perlini, Luca; Pierno, Matteo; Brinkmann, Martin; Mistura, Giampaolo

    2016-01-01

    We present systematic wetting experiments and numerical simulations of gravity driven liquid drops sliding on a plane substrate decorated with a linear chemical step. Surprisingly, the optimal direction to observe crossing is not the one perpendicular to the step, but a finite angle that depends on the material parameters. We computed the landscapes of the force acting on the drop by means of a contact line mobility model showing that contact angle hysteresis dominates the dynamics at the step and determines whether the drop passes onto the lower substrate. This analysis is very well supported by the experimental dynamic phase diagram in terms of pinning, crossing, sliding and sliding followed by pinning.

  8. Clival chordoma manifesting as nasal bleeding. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kitai, Ryuhei; Yoshida, Kazuhiko; Kubota, Toshihiko; Sato, Kazufumi; Handa, Yuji; Kasahara, Kazuma [University of Fukui, Department of Neurosurgery, Fukui (Japan); Nakajima, Hirofumi [Tsuruga Municipal Hospital, Department of Neurosurgery, Fukui (Japan)

    2005-05-01

    Chordoma is a rare cartilaginous tumor, for which bleeding presentation is unusual. We report a case of rare hemorrhaged clival chordoma, which was diagnosed correctly by magnetic resonance imaging. A 32-year-old man presented with nasal bleeding. The tumor was totally removed via a trans-sphenoidal approach, from which the surgical specimen confirmed chordoma. Epistaxis seemed to be caused by the spreading of the intratumoral hemorrhage into the sphenoid sinus. This case demonstrates the importance of an exact differential diagnostic evaluation, including chordoma, by use of modern imaging techniques for nasal bleeding. (orig.)

  9. STUDY OF NASAL INDEX AMONG STUDENTS OF TERTIARY MEDICAL CARE INSTITUTE IN SOUTHERN INDIA

    Directory of Open Access Journals (Sweden)

    Asharani S K

    2015-12-01

    Full Text Available Background: India is an ancient country having a diverse population group of various races, ethnic groups and tribes living in different climatic conditions. Nasal index is an ethnic sensitive anthropometric index which is used to classify race and sex of an individual. Aim: To study the Nasal index by using nasal parameters like Nasal height and Nasal width among students of South India and North India. Materials and Method: The study was done on medical students (male and female aged between 18-23yrs of age after obtaining the necessary consent. Nasal height and nasal width were measured with the aid of sliding caliper. On the basis of nasal height and nasal width, nasal index was calculated and the data was analyzed statistically. Results: The present study revealed that majority of the Indian population (both South India and North India belong to mesorrhinae type of nasal form followed by platyrrhinae and leptorrhinae. Conclusion: The majority of the Indian population belongs to mesorrhinae type of nasal form. The particular data will be of importance in forensic science, anthropology and rhinoplasty.

  10. Rhino-sinusitis related to endosseous implants extending into the nasal cavity - A case report

    NARCIS (Netherlands)

    Raghoebar, GM; van Weissenbruch, R; Vissink, A

    2004-01-01

    Rhino-sinusitis may develop as a result of an altered airflow in the nasal cavity causing irritation of the nasal mucosa. A patient is presented who developed recurrent rhino-sinusitis complaints following placement of endosseous implants in the maxilla. Inspection of the nasal floor revealed that t

  11. Acute effects of nasal salmon calcitonin on calcium and bone metabolism

    DEFF Research Database (Denmark)

    Thamsborg, G; Skousgaard, S G; Daugaard, H;

    1993-01-01

    .7 (3.2) nmol/mmol after nasal SCT (P = 0.04). Nasal SCT did not change the serum levels of alkaline phosphatase, osteocalcin, and the carboxyterminal propeptide of type 1 procollagen. The results indicate that nasal SCT given as a single dose provokes a modest decrease in bone resorption lasting...

  12. Nasal visualization on radioiodine whole-body scintigraphy due to benign abnormality.

    Science.gov (United States)

    Jiang, Xue; Wang, Qiao; Huang, Rui

    2015-04-01

    Nasal iodine activity can be observed on 123Iodine (123I) or 131I whole-body scintigraphy (WBS) commonly as a normal variant caused by nasal or salivary secretion of the tracer. We encountered 2 patients whose increased accumulation of 131I activity was associated with underlying abnormalities. One patient had a nasal polyp, whereas the other had an abscess.

  13. A secure method of nasal endotracheal tube stabilization with suture and rubber tube.

    Science.gov (United States)

    Ota, Y; Karakida, K; Aoki, T; Yamazaki, H; Arai, I; Mori, Y; Nakatogawa, N; Suzuki, T

    2001-12-01

    A new method of stabilizing the nasal endotrascheal tube was described. The tube was secured to the anterior portion of the nasal septum with braided silk thread, which was tightened over the rubber tube to keep air route of the cuff open. There found no complications such as unplanned extubation, necrosis and infections of the nasal septum.

  14. Aligner for Elastic Collisions of Dropped Balls.

    Science.gov (United States)

    Mellen, Walter Roy

    1995-01-01

    Discusses an aligner that permits dropping a stack of any number of balls of different sizes, elasticities, hardnesses, or types to observe the rebound of the top ball. Experimental results allow a reasonable comparison with theory. (MVL)

  15. Micro-splashing by drop impacts

    KAUST Repository

    Thoroddsen, Sigurdur T.

    2012-07-18

    We use ultra-high-speed video imaging to observe directly the earliest onset of prompt splashing when a drop impacts onto a smooth solid surface. We capture the start of the ejecta sheet travelling along the solid substrate and show how it breaks up immediately upon emergence from the underneath the drop. The resulting micro-droplets are much smaller and faster than previously reported and may have gone unobserved owing to their very small size and rapid ejection velocities, which approach 100 m s-1, for typical impact conditions of large rain drops. We propose a phenomenological mechanism which predicts the velocity and size distribution of the resulting microdroplets. We also observe azimuthal undulations which may help promote the earliest breakup of the ejecta. This instability occurs in the cusp in the free surface where the drop surface meets the radially ejected liquid sheet. © 2012 Cambridge University Press.

  16. Electric field induced deformation of sessile drops

    Science.gov (United States)

    Corson, Lindsey; Tsakonas, Costas; Duffy, Brian; Mottram, Nigel; Brown, Carl; Wilson, Stephen

    2014-11-01

    The ability to control the shape of a drop with the application of an electric field has been exploited for many technological applications including measuring surface tension, producing an optical display device, and optimising the optical properties of microlenses. In this work we consider, both theoretically and experimentally, the deformation of pinned sessile drops with contact angles close to either 0° or 90° resting on the lower substrate inside a parallel plate capacitor due to an A.C. electric field. Using both asymptotic and numerical approaches we obtain predictive equations for the static and dynamic drop shape deformations as functions of the key experimental parameters (drop size, capacitor plate separation, electric field magnitude and contact angle). The asymptotic results agree well with the experimental results for a range of liquids. We gratefully acknowledge the financial support of EPSRC via research Grants EP/J009865 and EP/J009873.

  17. Drop impact of shear thickening liquids

    CERN Document Server

    Boyer, Francois; Dijksman, J Frits; Lohse, Detlef

    2013-01-01

    The impact of drops of concentrated non-Brownian suspensions (cornstarch and polystyrene spheres) onto a solid surface is investigated experimentally. The spreading dynamics and maxi- mal deformation of the droplet of such shear thickening liquids are found to be markedly different from the impact of Newtonian drops. A particularly striking observation is that the maximal de- formation is independent of the drop velocity and that the deformation suddenly stops during the impact phase. Both observations are due to the shear-thickening rheology of the suspensions, as is theoretically explained from a balance between the kinetic energy and the viscously-dissipated en- ergy, from which we establish a scaling relation between drop maximal deformation and rheological parameters of concentrated suspensions.

  18. Shapes of Bubbles and Drops in Motion.

    Science.gov (United States)

    O'Connell, James

    2000-01-01

    Explains the shape distortions that take place in fluid packets (bubbles or drops) with steady flow motion by using the laws of Archimedes, Pascal, and Bernoulli rather than advanced vector calculus. (WRM)

  19. Rotating Drops of Axion Dark Matter

    CERN Document Server

    Davidson, Sacha

    2016-01-01

    We consider how QCD axions produced by the misalignment mechanism could form galactic dark matter halos. We recall that stationary, gravitationally stable axion field configurations have the size of an asteroid with masses of order $10^{-13} $ solar masses (because gradient pressure is insufficient to support a larger object). We call such field configurations "drops". We explore whether rotating drops could be larger, and find that their mass could increase by a factor ~ 10. Remarkably this mass is comparable to the mass of miniclusters generated from misalignment axions in the scenario where the axion is born after inflation. We speculate that misalignment axions today are in the form of drops, contributing to dark matter like a distribution of asteroids (and not as a coherent oscillating background field). We consider some observational signatures of the drops, which seem consistent with a galactic halo made of axion dark matter.

  20. Proceedings of the Second International Colloquium on Drops and Bubbles

    Science.gov (United States)

    Lecroissette, D. H. (Editor)

    1982-01-01

    Applications of bubble and drop technologies are discussed and include: low gravity manufacturing, containerless melts, microballoon fabrication, ink printers, laser fusion targets, generation of organic glass and metal shells, and space processing. The fluid dynamics of bubbles and drops were examined. Thermomigration, capillary flow, and interfacial tension are discussed. Techniques for drop control are presented and include drop size control and drop shape control.

  1. Total Gaussian curvature, drop shapes and the range of applicability of drop shape techniques.

    Science.gov (United States)

    Saad, Sameh M I; Neumann, A Wilhelm

    2014-02-01

    Drop shape techniques are used extensively for surface tension measurement. It is well-documented that, as the drop/bubble shape becomes close to spherical, the performance of all drop shape techniques deteriorates. There have been efforts quantifying the range of applicability of drop techniques by studying the deviation of Laplacian drops from the spherical shape. A shape parameter was introduced in the literature and was modified several times to accommodate different drop constellations. However, new problems arise every time a new configuration is considered. Therefore, there is a need for a universal shape parameter applicable to pendant drops, sessile drops, liquid bridges as well as captive bubbles. In this work, the use of the total Gaussian curvature in a unified approach for the shape parameter is introduced for that purpose. The total Gaussian curvature is a dimensionless quantity that is commonly used in differential geometry and surface thermodynamics, and can be easily calculated for different Laplacian drop shapes. The new definition of the shape parameter using the total Gaussian curvature is applied here to both pendant and constrained sessile drops as an illustration. The analysis showed that the new definition is superior and reflects experimental results better than previous definitions, especially at extreme values of the Bond number.

  2. Lesao nasal precoce pelo uso da pronga nasal em recem-nascidos prematuros de muito baixo peso: estudo piloto

    Directory of Open Access Journals (Sweden)

    Nathalie Tiemi Ota

    2013-09-01

    Full Text Available OBJETIVO: Analisar, em recém-nascidos de muito baixo peso e com indicação de ventilação não invasiva via pronga nasal, a incidência do aparecimento precoce de lesão nasal. MÉTODOS: Série de casos prospectiva de nascidos com idade gestacional <37 semanas, peso <1.500g e idade pós-natal <29 dias. Os pacientes foram avaliados desde a instalação da pronga nasal até o 3o dia de uso, três vezes ao dia. Foram analisadas as condições clínicas dos pacientes, características do dispositivo e de sua aplicação. A análise inicial foi descritiva, verificando-se a prevalência de lesão nasal bem como os fatores a ela associados. Os dados categóricos foram analisados por qui-quadrado ou exato de Fisher e os dados numéricos, por teste t ou Mann-Whitney. RESULTADOS: Dezoito recém-nascidos foram incluídos, dos quais 12 (idade gestacional de 29,8±3,1 semanas, peso ao nascer de 1.070±194g e Score for Neonatal Acute Phisiology - Perinatal Extension (SNAPPE de 15,4±17,5 evoluíram com lesão nasal (Grupo Lesão e 6 (idade gestacional de 28,0±1,9 semanas, peso de 1.003±317g e SNAPPE de 26,2±7,5 não apresentaram lesão nasal (Grupo Sem Lesão. No Grupo Lesão, houve maior frequência do gênero masculino (75% versus 17%, a lesão apareceu em média após 18 horas e predominantemente no período notur no (75%. CONCLUSÃO: A incidência de lesão nasal em prematuros submetidos à ventilação não invasiva via pronga nasal foi elevada, sendo possível planejar estudo dos fatores associados, com base neste piloto.

  3. Drop Performance Test of CRDMs for JRTR

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Myoung-Hwan; Cho, Yeong-Garp; Chung, Jong-Ha [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jung-Hyun [POSCO Plandtec Co. Ltd, Ulsan (Korea, Republic of); Lee, Kwan-Hee [RIST, Pohang (Korea, Republic of)

    2015-10-15

    The drop test results of CRDMs with AC-type electromagnet show that the initial delay times are not satisfied with the requirement, 0.15 seconds. After the replacement of the electromagnet from AC-type to DCtype, the drop times of CARs and accelerations due to the impact of moving parts are satisfied with all requirements. As a result, it is found that four CRDMs to be installed at site have a good drop performance, and meet all performance requirements. A control rod drive mechanism (CRDM) is a device to control the position of a control absorber rod (CAR) in the core by using a stepping motor which is commanded by the reactor regulating system (RRS) to control the reactivity during the normal operation of the reactor. The top-mounted CRDM driven by the stepping motor for Jordan Research and Training Reactor (JRTR) has been developed in KAERI. The CRDM for JRTR has been optimized by the design improvement based on that of the HANARO. It is necessary to verify the performances such as the stepping, drop, endurance, vibration, seismic and structural integrity for active components. Especially, the CAR drop curves are important data for the safety analysis. This paper describes the test results to demonstrate the drop performances of a prototype and 4 CRDMs to be installed at site. The tests are carried out at a test rig simulating the actual reactor's conditions.

  4. Toroidal bubble entrapment under an impacting drop

    Science.gov (United States)

    Thoraval, Marie-Jean; Thoroddsen, Sigurdur T.; Takehara, Kohsei; Etoh, Takeharu Goji

    2012-11-01

    We use ultra-high-speed imaging and numerical simulations (GERRIS, http://gfs.sf.net) to observe and analyze the formation of up to 14 air tori when a water drop impacts on a thin liquid film of water or other miscible liquids. They form during the early contact between the drop and the pool by the vertical oscillations of the ejecta sheet. They then break in micro-bubble rings by the Rayleigh instability. Their formation is associated with the shedding of an axisymmetric vortex street into the liquid from the free surface. These vorticity structures and their dynamics are made apparent by the dynamics of the micro-bubbles, added seed particles and the difference of refractive index for different liquids in the drop and the pool. More robust entrapments are observed for a thin film of ethanol or methanol. We show that while the non-spherical drop shape is not responsible for the toroidal bubble entrapments, the number of rings is increasing for more oblate drops. Individual bubble entrapments are also observed from azimuthal destabilizations of the neck between the drop and the pool.

  5. Electrohydrodynamics of a surfactant-covered drop

    Science.gov (United States)

    Oberlander, Andrew; Ouriemi, Malika; Vlahovska, Petia

    2014-11-01

    We present an experimental study of the behavior of a drop covered with insoluble surfactant in a uniform DC electric field. Steady drop shapes, drop evolution upon application of the field, and drop relaxation after the field is turned off are observed for a polybutadiene (PB) drop suspended in silicon oil (PDMS). The surfactant is generated at the drop interface by reaction between end-functionalized PB and PDMS. The experimental data is compared with the theory of Nganguia et al. (2013) for the steady shapes, and a new model developed by us which accounts for polarization relaxation. The latter effect turns to be significant for our system of very low conductivity fluids, for which the Maxwell-Wagner time is of the order of tens of seconds. We will discuss the complex interplay of shape deformation, surfactant redistribution, and interfacial charging in droplet electrohydrodynamics. Our results are important for understanding electrorheology of emulsions commonly found in the petroleum industry. Supported by NSF-CBET-1132614.

  6. Electrochemistry in an acoustically levitated drop.

    Science.gov (United States)

    Chainani, Edward T; Ngo, Khanh T; Scheeline, Alexander

    2013-02-19

    Levitated drops show potential as microreactors, especially when radicals are present as reactants or products. Solid/liquid interfaces are absent or minimized, avoiding adsorption and interfacial reaction of conventional microfluidics. We report amperometric detection in an acoustically levitated drop with simultaneous ballistic addition of reactant. A gold microelectrode sensor was fabricated with a lithographic process; active electrode area was defined by a photosensitive polyimide mask. The microdisk gold working electrode of radius 19 μm was characterized using ferrocenemethanol in aqueous buffer. Using cyclic voltammetry, the electrochemically active surface area was estimated by combining a recessed microdisk electrode model with the Randles-Sevcik equation. Computer-controlled ballistic introduction of reactant droplets into the levitated drop was developed. Chronoamperometric measurements of ferrocyanide added ballistically demonstrate electrochemical monitoring using the microfabricated electrode in a levitated drop. Although concentration increases with time due to drop evaporation, the extent of concentration is predictable with a linear evaporation model. Comparison of diffusion-limited currents in pendant and levitated drops show that convection arising from acoustic levitation causes an enhancement of diffusion-limited current on the order of 16%. PMID:23351154

  7. Leidenfrost drops on liquid baths: theory

    Science.gov (United States)

    Sobac, Benjamin; Rednikov, Alexei; Maquet, Laurent; Darbois-Texier, Baptiste; Duchesne, Alexis; Brandenbourger, Martin; Dorbolo, Stéphane; Colinet, Pierre

    2015-11-01

    It is well known that a liquid drop released over a very hot surface generally does not contact the surface nor boils but rather levitates over a thin vapor film generated by its own evaporation (Leidenfrost effect). In particular, the case of a hot (and flat) solid substrate has been extensively studied in recent years. In contrast, we here focus on Leidenfrost drops over a superheated liquid bath, addressing the problem theoretically and comparing our predictions with experimental results, detailed in a separate talk. We predict the geometry of the drop and of the liquid bath, based on the hydrostatic Young-Laplace and lubrication equations. A good agreement is observed with the available experimental data concerning the deformation of the liquid bath. The modeling also yields a rather complete insight into the shape of the drop. As in the case of a solid substrate, the vapor layer generally appears to be composed of a vapor pocket surrounded by a circular neck. The influences of the superheat and of the drop size are parametrically investigated. A number of scaling laws are established. Unlike the case of a solid substrate, no chimney instability was found in the range of drop size studied.

  8. Drops can bounce from perfectly hydrophilic surfaces

    Science.gov (United States)

    Kolinski, J. M.; Mahadevan, L.; Rubinstein, S. M.

    2014-10-01

    Drops are well known to rebound from superhydrophobic surfaces and from liquid surfaces. Here, we show that drops can also rebound from a superhydrophilic solid surface such as an atomically smooth mica sheet. However, the coefficient of restitution CR associated with this process is significantly lower than that associated with rebound from superhydrophobic surfaces. A direct imaging method allows us to characterize the dynamics of the deformation of the drop in entering the vicinity of the surface. We find that drop bouncing occurs without the drop ever touching the solid and there is a nanometer-scale film of air that separates the liquid and solid, suggesting that shear in the air film is the dominant source of dissipation during rebound. Furthermore, we see that any discrete nanometer-height defects on an otherwise hydrophilic surface, such as treated glass, completely inhibits the bouncing of the drop, causing the liquid to wet the surface. Our study adds a new facet to the dynamics of droplet impact by emphasizing that the thin film of air can play a role not just in the context of splashing but also bouncing, while highlighting the role of rare surface defects in inhibiting this response.

  9. Efeito do exercício físico sobre o volume nasal Effects of physical exercise in nasal volume

    Directory of Open Access Journals (Sweden)

    Marconi Teixeira Fonseca

    2006-04-01

    Full Text Available A variação da permeabilidade nasal tem sido demonstrada usando-se várias técnicas de exame. As estruturas nasais geram uma resistência que representa cerca de 50% da resistência respiratória total. O exercício físico é um dos fatores que pode causar um efeito vasoconstritor sobre a mucosa nasal. OBJETIVO: O objetivo deste estudo é avaliar o grau de mudança do volume nasal após exercício físico e o tempo de retorno aos níveis basais. MATERIAIS E MÉTODOS: Dezenove indivíduos foram submetidos à realização de teste físico em bicicleta ergométrica. O volume nasal foi obtido através da rinometria acústica, realizada em repouso, após o fim do exercício físico, e nos minutos décimo e vigésimo de seu final. RESULTADOS: Os resultados rinométricos mostram um aumento estatisticamente significativo do volume nasal (p The nasal permeability has been demonstrated using several exams. Nasal structures produces a resistance to the nasal air flux that represents over 50% of the total respiratory resistance. Physical exercises is a factor that brings a vasoconstrictor effect over nasal mucosa. AINS: Evaluate the improvement degree of nasal volume after aerobic physical exercises and time to return to previous levels. SUBJECTS AND METHODS: Nineteen heathly subjects were submitted to aerobic exercise in ergometric bike. The nasal volume was obtained by Acoustic Rhinometry perfomed in rest, after aerobic exercise, 10o and 20o minutes after the aerobic exercise. RESULTS: Rhynometrics results shows a statically and significant increase of nasal volume (p<0,001. The nasal volume, in twenty minutes, returns nearby the rest levels. CONCLUSIONS: Aerobic exercises, generally, increases the nasal volume. However, the increase of nasal volume was transitory, and occurs a major reduction of increase in the first ten minutes after the exercises ends, and perform a greater vasoconstrictor effect over nasal mucosa, Twenty minutes after the physical

  10. Polymorphous low-grade adenocarcinoma of the nasal fossa.

    Science.gov (United States)

    González-Lagunas, Javier; Alasà-Caparrós, Cristian; Vendrell-Escofet, Gerard; Huguet-Redecilla, Pere; Raspall-Martin, Guillermo

    2005-01-01

    An unusual case of a T4N2CMx polymorphous low grade adenocarcinoma located in the nasal fossae and extending to the pterygoid area is presented. The primary tumor was excised through a Lefort I maxillotomy and the neck was managed with a supraomohyoid neck dissection. Adjuntive postoperative radiotherapy was also administered to the patient.

  11. Effect of sleeping position on nasal patency in newborns

    OpenAIRE

    Olarinde, O; Banerjee, A R; O'Callaghan, C

    2006-01-01

    Sleeping posture has been implicated in the pathophysiology of sudden infant death syndrome. The effect of supine and lateral sleeping positions on nasal patency was investigated using acoustic rhinometry in 11 healthy newborns. The implications of the findings in sudden infant death syndrome are discussed.

  12. Thermally reversible xyloglucan gels as vehicles for nasal drug delivery.

    Science.gov (United States)

    Mahajan, Hitendra S; Tyagi, Vinod; Lohiya, Gopal; Nerkar, Pankaj

    2012-01-01

    The aim of this study was to investigate the potential application of thermosensitive gels formed by a xyloglucan polysaccharide derived from tamarind seed for nasal drug delivery. Xyloglucan that had been partially degraded by β-galactosidase to eliminate 45% of galactose residues formed gels at concentrations of 2.5% w/w at gelation temperatures decreasing over the range 27-28°C. The in vitro release of ondansetron hydrochloride from the enzyme-degraded xyloglucan gels followed higuchi kinetics over a period of 5 h at 34°C by anomalous transport mechanism. The ex vivo permeation of ondansetron hydrochloride from the gels was sustained. Histological examination of nasal mucosa following a single administration of the gels showed no evidence of mucosal damage. Finally, the bioavailability study in rabbits revealed that the absolute bioavailability of ondansetron hydrochloride was significantly increased from 28.64% in the case of the oral drug solution to 52.79% in the case of the nasal in situ gel. The results of this study suggest the potential of the enzyme-degraded xyloglucan gels as vehicles for nasal delivery of drugs.

  13. The Fungi Flora of Healthy Nasal Mucosa in Kerman, Iran

    Directory of Open Access Journals (Sweden)

    Narges Khanjani

    2011-04-01

    Full Text Available Introduction: Environmental fungi, molds and yeasts, can infest the nasal cavity through inhaled air. There is some evidence that they could be the main cause of Chronic Rhinosinusitis (CRS but little is known about the normal fungal flora in the human nose. The objective of this study was to assess the normal fungal flora of the nasal mucus in adults in Kerman. Materials and Methods: We conducted a cross sectional study. Nasal swabs were used to sample the nasal cavity of 100 adults, 46 men and 54 women between 17 and 60 years old, currently living in Kerman, Iran. Results: Among 100 healthy people, one or more types of fungi were detected in 31 (31% persons; Candida in 12 persons, Aspergillus in 8 persons, Streptomyces in 8 persons, and Penicillium, Nocardia and Mucor in a few persons. In only 4 persons, more than one type of fungi was detected.  There was no significant relation between age, sex, education or smoking with the presence of fungi. Conclusion: Fungi have been considered one of the causative agents of CRS and differences in climatic conditions can influence the fungi flora.

  14. Case Report of Nasal Polyp Treated by Acupuncture

    Institute of Scientific and Technical Information of China (English)

    蒋传义

    2007-01-01

    @@ A Patient, female, student, nineteen years old.She was diagnosed with rhinitis and nasal polyps at the age of 17, and was treated with many methods,but the disease was not cured. The patient and her parents were fearful of surgical treatment, so she came for acupuncture therapy.

  15. Nicotine nasal spray and vapor inhaler: abuse liability assessment.

    Science.gov (United States)

    Schuh, K J; Schuh, L M; Henningfield, J E; Stitzer, M L

    1997-04-01

    Acute subjective and physiological effects were examined to provide information relevant to abuse liability of new nicotine delivery systems. Subjects (n = 12) were overnight-deprived smokers who received 0, 4, 8 and 16 active puffs from nicotine-containing cigarettes (0.1 mg per puff), 0, 1, 2 or 4 nasal sprays (0.5 mg nicotine per spray) and 0, 30, 60 and 120 vapor inhalations (estimated 0.013 mg nicotine per inhalation) in a within-subject single blinded design. While smokers clearly liked cigarette puffs, there was much less evidence of liking produced by either nasal spray or vapor inhaler; only modest elevations on a measure of good drug effects were observed. The novel delivery products engendered unpleasant effects of burning throat and nose, watery eyes, runny nose, coughing and sneezing that might be expected to limit abuse liability. Nicotine plasma level and heart rate increase was dose-related for cigarettes and nasal spray but not for vapor inhaler, indicating limited nicotine delivery with the latter device. Overall, results are consistent with the conclusion that the nicotine nasal spray and vapor inhaler are of substantially lower abuse liability than cigarettes in experienced cigarette smokers receiving initial exposure to these products. PMID:9160851

  16. Nasal versus temporal preretinal vasoproliferation in retinopathy of prematurity.

    OpenAIRE

    Nissenkorn, I; Kremer, I; Cohen, S.; Ben-Sira, I

    1989-01-01

    Nasal preretinal neovascularisations have been observed to develop at least two weeks earlier than those on the temporal side in more than a third of premature babies with retinopathy of prematurity (ROP) stage 3, weighing between 690 and 1030 g. All these babies were assigned for cryotherapy. This interesting observation is discussed in relation to retinal vascular development and the pathogenesis of ROP.

  17. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists

    OpenAIRE

    Brant, Tereza C S; Yoshida, Carolina T; Tomas de S. Carvalho; Nicola, Marina L; Jocimar. A. Martins; Lays M. Braga; Regiani C. de Oliveira; Vilma Leyton; Carmen S. de André; Saldiva, Paulo H. N.; Rubin, Bruce K.; Naomi K. Nakagawa

    2014-01-01

    OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS:...

  18. Effect of Mupirocin on Nasal Carriage of Staphylococcus Aureus

    NARCIS (Netherlands)

    M. Bulanda; M. Gruszka; B. Heczko

    1989-01-01

    textabstractMupirocin eliminates nasal carriage of staphylococcal aureus among medical and surgical personnel for periode varying from several weeks upto one year. In persons recolonized after therapy densites of S. aureus population in nares were much lower than in the same persons before therapy.

  19. High flow nasal cannula for respiratory support in preterm infants.

    LENUS (Irish Health Repository)

    Wilkinson, Dominic

    2011-01-01

    High flow nasal cannulae (HFNC) are small, thin, tapered cannulae used to deliver oxygen or blended oxygen and air at flow rates of > 1 L\\/min. HFNC can be used to provide high concentrations of oxygen and may deliver positive end-expiratory pressure.

  20. Effects of diesel exhaust on influenza-induced nasal inflammation

    Science.gov (United States)

    Title: Effects of Diesel Exhaust on Influenza-Induced Nasal Inflammation T L Noah, MD1,2, K Horvath, BS3, C Robinette, RN2, 0 Diaz Sanchez, PhD4 and I Jaspers, PhD1,2. 1UNC Dept. of Pediatrics, United States; 2UNC Center for Environmental Medicine, Asthma and Lung Biology, ...

  1. Comparing the Effectiveness of Nasal Continuous Positive Airway Pressure (NCPAP) and High Flow Nasal Cannula (HFNC) in Prevention of Post Extubation Assisted Ventilation

    OpenAIRE

    Manizheh Mostafa-Gharehbaghi; Hooshyar Mojabi

    2015-01-01

    Background: There is a growing trend toward avoidance of intubation and mechanical ventilation for preterm neonates. Noninvasive ventilation can be provided by a variety of ways including nasal cannula. Objectives: This study was conducted to compare the efficacy and safety of Humidified high Flow Nasal Cannula (HFNC) and nasal CPAP for respiratory support after surfactant administration in preterm newborn infants with respiratory distress syndrome. Patients and Methods: In this r...

  2. A Comparative Study of Airflow and Odorant Deposition in the Mammalian Nasal Cavity

    Science.gov (United States)

    Richter, Joseph; Rumple, Christopher; Ranslow, Allison; Quigley, Andrew; Pang, Benison; Neuberger, Thomas; Krane, Michael; van Valkenburgh, Blaire; Craven, Brent

    2013-11-01

    The complex structure of the mammalian nasal cavity provides a tortuous airflow path and a large surface area for respiratory air conditioning, filtering of inspired contaminants, and olfaction. Due to the small and contorted structure of the nasal turbinals, nasal anatomy and function remains poorly understood in most mammals. Here, we utilize high-resolution MRI scans to reconstruct anatomically-accurate models of the mammalian nasal cavity. These data are used to compare the form and function of the mammalian nose. High-fidelity computational fluid dynamics (CFD) simulations of nasal airflow and odorant deposition are presented and used to compare olfactory function across species (primate, rodent, canine, feline, ungulate).

  3. CT findings of nasal non-Hodgkin`s lymphomas associated with prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Yuki; Matsubayashi, Takashi; Kan, Shinichi; Ikeda, Toshiaki; Nishiguchi, Iku [Kitasato Univ., Sagamihara, Kanagawa (Japan). School of Medicine

    1999-02-01

    X-ray CT images of the head obtained from thirteen patients (9 men and 4 women) among 33 patients (19 men and 14 women) with nasal non-Hodgkin`s lymphoma (NHL) who had been seen at Kitasato University Hospital during the period from April 1975 to March 1995 were retrospectively reviewed to search for useful prognostic image factors for nasal NHL. Extracavitary subcutaneous tumor extension into the nasal wing or cheek, and tumor penetration through the nasal septum revealed on X-ray CT images seemed to be likely indicators of a poor prognosis for patients with nasal NHL. (author)

  4. Staphylococcus aureus nasal carriage in hemodialysis centers of Fez, Morocco.

    Directory of Open Access Journals (Sweden)

    Idrissa Diawara

    2014-06-01

    Full Text Available Staphylococcus aureus (S. aureus nasal carriage may be responsible for some serious infections in hemodialyzed patients. The main target of this study was to estimate the prevalence of S. aureus nasal carriage in hemodialysis outpatients and medical staff in hemodialysis centers specifically in Fez region. The second target is to identify the risks of colonization, resistance pattern of isolates and their virulence toxin genes.Nasal swab specimens were obtained from 143 hemodialyzed outpatients and 32 medical staff from January to June 2012. Each participant completed a short questionnaire. Nasal carriage of S. aureus was demographically related (age, gender, hemodialysis duration, comorbidity (diabetes, malignancy and exposure to health care (dialysis staff, hospitalization. PCR (Polymerase Chain Reaction were used on all the isolates in the research of twelve staphylococcal enterotoxins genes. Also the PCR was used to investigate on the three factors epidermal cell differentiation inhibitors; three exfoliatin toxins; two leukotoxins; the toxic shock syndrome toxin-1 and the hemolysin beta genes.Nasal screening revealed 38.16%, 50% and 18.75% S. aureus carries in chronic, acute hemodialysis patients and medical staff, respectively. Only young participants were likely to be S. aureus carries (p = 0.002. But there were no gender differences between the isolate carriers and non-carriers or some comorbidity factors such as viral hepatitis B and C, HIV (Human Immunodeficiency Virus infections, diabetes, chronic smoking, recent hospitalization or antibiotic therapy. Out of all isolates, only one (1.61% was methicillin-resistant and Twenty-one (33.87% had at least two virulence toxin genes.Knowledge and monitoring of antibiotic resistance profile and virulence of S. aureus carriage are essential in the treatment of infections generated by this pathogen, as well as in the control of clonal dissemination and prevent the spread of S. aureus resistance.

  5. NUTRITIONAL STATUS, VITAMIN D AND NASAL COLONIZATION IN SPINAL SURGERY

    Directory of Open Access Journals (Sweden)

    Diego Benone dos Santos

    2016-03-01

    Full Text Available ABSTRACT Objective: Evaluate the nutritional status, vitamin D, the serum albumin, and the nasal colonization by bacteria in a Brazilian population sample that included specifically patients undergoing spine surgery Methods: The serum albumin and vitamin D tests were performed on blood samples; nasal microbiological research was performed by swab and demographic information was collected. We studied the correlation between the tests and gender and age groups of patients. Results: Seventy-five patients were included. Of this total, 74 patients underwent testing of albumin levels, 64 of vitamin D and 41 underwent nasal swab. The mean of serum albumin was 3.76 g/dl (SD = 0.53 g/dl; 70.3% of subjects were considered normal and 29.7% showed hypoalbuminemia. Regarding vitamin D, the mean was 16.64 ng/ml (SD: 7.43 ng/ml; 64.1% of patients were considered deficient, 32.8% insufficient, and 3.1% were considered normal. There was significant difference between albumin and age (p=0.007, being that the greater the age, the lower the albumin. Hypoalbuminemia was significantly more frequent over 60 years (p<0.001. There was no correlation between vitamin D or nasal swab and age (p=0.603 and 0.725, respectively. The correlation between the tests and gender showed no significant difference in any of the parameters. Conclusion: The serum albumin and vitamin D levels and results of nasal swab were presented for a Brazilian sample of patients undergoing spine surgery. It was found correlation between hypoalbuminemia (inferring malnutrition and age group of patients. Almost all the patients had some degree of vitamin D deficiency, with no correlation with age.

  6. Does Nasal Septal Deviation Affect the Success of Tympanoplasty Surgery?

    Science.gov (United States)

    Tan, M; Kalcioglu, MT; Akarcay, M; Toplu, Y; Karaca, S

    2015-01-01

    ABSTRACT Objective: This paper deals with the investigation of the effects of nasal septal deviation evaluated by acoustic rhinometry (ARM) in the success of tympanoplasty surgery. Subject and Methods: All patients who underwent tympanoplasty surgery by the same surgeon were reviewed. The patients with nasopharyngeal or nasal masses, polyps, symptoms of allergic rhinitis or rhinosinusitis, or concha bullosa were excluded from the study. Forty patients who underwent tympanoplasty at least one year ago were included in the study. The patients were divided into two groups according to the graft success results. Acoustic rhinometry evaluations of the patients were performed. Results: There were 25 and 15 cases in the intact graft (group A) and re-perforated group (group B), respectively. For the same side of the operated ear, ARM values of group A were 0.47 cm 2 at the first narrowest cross-sectional area (MCA 1), 0.43 cm2 at the second narrowest cross-sectional area (MCA 2), 1.51 cm3 volume at the first 2 cm of the nasal cavity (Vol 1) and 3.33 cm3 volume between the second and fifth cm of the nasal cavity (Vol 2). Acoustic rhinometry values of group B were 0.50 cm2, 0.47 cm2, 1.60 cm3 and 3.19 cm3 for MCA 1, MCA 2, Vol 1, and Vol 2, respectively. Conclusion: The results of this study showed that nasal septal deviation may not affect the success of tympanoplasty surgery, and septoplasty may not be necessary before ear surgery. PMID:26624593

  7. Charge and Size Distributions of Electrospray Drops

    Science.gov (United States)

    de Juan L; de la Mora JF

    1997-02-15

    The distributions of charge q and diameter d of drops emitted from electrified liquid cones in the cone-jet mode are investigated with two aerosol instruments. A differential mobility analyzer (DMA, Vienna type) first samples the spray drops, selects those with electrical mobilities within a narrow band, and either measures the associated current or passes them to a second instrument. The drops may also be individually counted optically and sized by sampling them into an aerodynamic size spectrometer (API's Aerosizer). For a given cone-jet, the distribution of charge q for the main electrospray drops is some 2.5 times broader than their distribution of diameters d, with qmax/qmin approximately 4. But mobility-selected drops have relative standard deviations of only 5% for both d and q, showing that the support of the (q, d) distribution is a narrow band centered around a curve q(d). The approximate one-dimensionality of this support region is explained through the mechanism of jet breakup, which is a random process with only one degree of freedom: the wavelength of axial modulation of the jet. The observed near constancy of the charge over volume ratio (q approximately d3) shows that the charge is frozen in the liquid surface at the time scale of the breakup process. The charge over volume ratio of the primary drops varies between 98 and 55% of the ratio of spray current I over liquid flow rate Q, and decreases at increasing Q. I/Q is therefore an unreliable measure of the charge density of these drops.

  8. Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formmaldehyde Dosimetry Predictions in the Rat, Monkey, and Human Nasal Passages

    Science.gov (United States)

    ABSTRACT Formaldehyde, a nasal carcinogen, is also an endogenous compound that is present in all living cells. Due to its high solubility and reactivity, quantitative risk estimates for inhaled formaldehyde rely on internal dose calculations in the upper respiratory tract which ...

  9. Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa : Effects of single allergen challenge

    NARCIS (Netherlands)

    Holm, A; Dijkstra, M; Kleinjan, A; Severijnen, LA; Boks, S; Mulder, P; Fokkens, W

    2001-01-01

    Background: Topical corticosteroid therapy reduces symptoms and nasal mucosal inflammatory cells in patients with allergic rhinitis. Usually patients are advised to start their medication (1 week) before the beginning of the pollen season. The effect of pretreatment with a topical corticosteroid on

  10. Shape oscillation of a levitated drop in an acoustic field

    CERN Document Server

    Ran, Weiyu

    2013-01-01

    A `star drop' refers to the patterns created when a drop, flattened by some force, is excited into shape mode oscillations. These patterns are perhaps best understood as the two dimensional analog to the more common three dimensional shape mode oscillations. In this fluid dynamics video an ultrasonic standing wave was used to levitate a liquid drop. The drop was then flattened into a disk by increasing the field strength. This flattened drop was then excited to create star drop patterns by exciting the drop at its resonance frequency. Different oscillatory modes were induced by varying the drop radius, fluid properties, and frequency at which the field strength was modulated.

  11. Stereoscopic PIV measurements of flow in the nasal cavity with high flow therapy

    Science.gov (United States)

    Spence, C. J. T.; Buchmann, N. A.; Jermy, M. C.; Moore, S. M.

    2011-04-01

    Knowledge of the airflow characteristics within the nasal cavity with nasal high flow (NHF) therapy and during unassisted breathing is essential to understand the treatment's efficacy. The distribution and velocity of the airflow in the nasal cavity with and without NHF cannula flow has been investigated using stereoscopic particle image velocimetry at steady peak expiration and inspiration. In vivo breathing flows were measured and dimensionally scaled to reproduce physiological conditions in vitro. A scaled model of the complete nasal cavity was constructed in transparent silicone and airflow simulated with an aqueous glycerine solution. NHF modifies nasal cavity flow patterns significantly, altering the proportion of inspiration and expiration through each passageway and producing jets with in vivo velocities up to 17.0 ms-1 for 30 l/min cannula flow. Velocity magnitudes differed appreciably between the left and right sides of the nasal cavity. The importance of using a three-component measurement technique when investigating nasal flows has been highlighted.

  12. Detection of helicobacter pylori in nasal polyps using rapid urease test and ELISA

    Directory of Open Access Journals (Sweden)

    Masood Kaviani

    2009-01-01

    Full Text Available Introduction: Nasal polyposis is an inflammatory condition of unknown etiology. Recently concerns regarding gastroesophageal reflux or helicobacter pylori as a possible pathologic cause of nasal polyps have been increasing. The present study was planned to investigate the presence of helicobacter pylori in nasal polyps. Materials and Methods: This case-control study was undertaken enrolling 37 patients with nasal polyps who had undergone nasal endoscopic sinus surgery and 38 control subjects. Biopsy specimens of nasal polyps and inferior turbinates were assessed by rapid urease test. Blood samples of both study and control subjects were evaluated for anti H.pylori IgG by ELISA. H. pylori status was regarded positive, if both tests were positive. Results: Seropositivity was more common in the patients with nasal polyps (66.2% than control subjects (36.8% (P

  13. An unusual cause of necrosis and nasal septum perforation after septoplasty: Enterobacter cloacae.

    Science.gov (United States)

    Binar, M; Arslan, F; Tasli, H; Karakoc, O; Kilic, A; Aydin, U

    2015-11-01

    A 20-year-old man with nasal obstruction underwent septoplasty due to nasal septal deviation. Nasal packs were inserted at the end of surgery and removed 48 hours after surgery. Twenty-four hours after removal of nasal packs, there was necrosis in both sides of septal mucosa and in bilateral inferior turbinates. Nasal swab culture was performed from both nasal cavities. Enterobacter cloacae was isolated from samples. Two weeks after surgery, nasal septum perforation was unavoidable. To our knowledge, this is the first case in literature describing septal mucosal necrosis caused by this pathogen after septoplasty. Mucosal necrosis and perforation as septoplasty complications should be kept in mind, the result of causes both common and, as in the present case, unusual. PMID:27257495

  14. An unusual cause of necrosis and nasal septum perforation after septoplasty: Enterobacter cloacae

    Directory of Open Access Journals (Sweden)

    M. Binar

    2015-11-01

    Full Text Available A 20-year-old man with nasal obstruction underwent septoplasty due to nasal septal deviation. Nasal packs were inserted at the end of surgery and removed 48 hours after surgery. Twenty-four hours after removal of nasal packs, there was necrosis in both sides of septal mucosa and in bilateral inferior turbinates. Nasal swab culture was performed from both nasal cavities. Enterobacter cloacae was isolated from samples. Two weeks after surgery, nasal septum perforation was unavoidable. To our knowledge, this is the first case in literature describing septal mucosal necrosis caused by this pathogen after septoplasty. Mucosal necrosis and perforation as septoplasty complications should be kept in mind, the result of causes both common and, as in the present case, unusual.

  15. Drop Testing Representative Multi-Canister Overpacks

    Energy Technology Data Exchange (ETDEWEB)

    Snow, Spencer D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Morton, Dana K. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-06-01

    The objective of the work reported herein was to determine the ability of the Multi- Canister Overpack (MCO) canister design to maintain its containment boundary after an accidental drop event. Two test MCO canisters were assembled at Hanford, prepared for testing at the Idaho National Engineering and Environmental Laboratory (INEEL), drop tested at Sandia National Laboratories, and evaluated back at the INEEL. In addition to the actual testing efforts, finite element plastic analysis techniques were used to make both pre-test and post-test predictions of the test MCOs structural deformations. The completed effort has demonstrated that the canister design is capable of maintaining a 50 psig pressure boundary after drop testing. Based on helium leak testing methods, one test MCO was determined to have a leakage rate not greater than 1x10-5 std cc/sec (prior internal helium presence prevented a more rigorous test) and the remaining test MCO had a measured leakage rate less than 1x10-7 std cc/sec (i.e., a leaktight containment) after the drop test. The effort has also demonstrated the capability of finite element methods using plastic analysis techniques to accurately predict the structural deformations of canisters subjected to an accidental drop event.

  16. Drops with non-circular footprints

    CERN Document Server

    Ravazzoli, Pablo D; Diez, Javier A

    2015-01-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. This type of drops is a consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to hysteresis effects of the contact angle since some parts of the contact line are wetting, while others are dewetting. Here, we obtain a peculiar drop shape from the rupture of a long liquid filament sitting on a solid substrate, and analyze its shape and contact angles by means of goniometric and refractive techniques. We also find a non--trivial steady state solution for the drop shape within the long wave approximation (lubrication theory), and compare most of its features with experimental data. This solution is presented both in Cartesian and polar coordinates, whose constants must be determined by a certain group of measured parameters. Besides, we obtain the dynamics of the drop generation from numerical simulations of...

  17. Drop impact entrapment of bubble rings

    KAUST Repository

    Thoraval, M.-J.

    2013-04-29

    We use ultra-high-speed video imaging to look at the initial contact of a drop impacting on a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et al. (Phys. Rev. Lett., vol. 108, 2012, article 264506). These dynamics mainly occur within 50 -s after the first contact, requiring imaging at 1 million f.p.s. For a water drop impacting on a thin layer of water, the entrapment of isolated bubbles starts through azimuthal instability, which forms at low impact velocities, in the neck connecting the drop and pool. For Reynolds number Re above -12 000, up to 10 partial bubble rings have been observed at the base of the ejecta, starting when the contact is -20% of the drop size. More regular bubble rings are observed for a pool of ethanol or methanol. The video imaging shows rotation around some of these air cylinders, which can temporarily delay their breakup into micro-bubbles. The different refractive index in the pool liquid reveals the destabilization of the vortices and the formation of streamwise vortices and intricate vortex tangles. Fine-scale axisymmetry is thereby destroyed. We show also that the shape of the drop has a strong influence on these dynamics. 2013 Cambridge University Press.

  18. Drop splash on a smooth, dry surface

    Science.gov (United States)

    Riboux, Guillaume; Gordillo, Jose Manuel; Korobkin, Alexander

    2013-11-01

    It is our purpose here to determine the conditions under which a drop of a given liquid with a known radius R impacting against a smooth impermeable surface at a velocity V, will either spread axisymmetrically onto the substrate or will create a splash, giving rise to usually undesired star-shaped patterns. In our experimental setup, drops are generated injecting low viscosity liquids falling under the action of gravity from a stainless steel hypodermic needle. The experimental observations using two high speed cameras operating simultaneously and placed perpendicularly to each other reveal that, initially, the drop deforms axisymmetrically, with A (T) the radius of the wetted area. For high enough values of the drop impact velocity, a thin sheet of liquid starts to be ejected from A (T) at a velocity Vjet > V for instants of time such that T >=Tc . If Vjet is above a certain threshold, which depends on the solid wetting properties as well as on the material properties of both the liquid and the atmospheric gas, the rim of the lamella dewets the solid to finally break into drops. Using Wagner's theory we demonstrate that A (T) =√{ 3 RVT } and our results also reveal that Tc We - 1 / 2 =(ρV2 R / σ) - 1 / 2 and Vjet We 1 / 4 .

  19. Drops with non-circular footprints

    Science.gov (United States)

    Ravazzoli, Pablo D.; González, Alejandro G.; Diez, Javier A.

    2016-04-01

    In this paper we study the morphology of drops formed on partially wetting substrates, whose footprint is not circular. These drops are consequence of the breakup processes occurring in thin films when anisotropic contact line motions take place. The anisotropy is basically due to the hysteresis of the contact angle since there is a wetting process in some parts of the contact line, while a dewetting occurs in other parts. Here, we obtain a characteristic drop shape from the rupture of a long liquid filament sitting on a solid substrate. We analyze its shape and contact angles by means of goniometric and refractive techniques. We also find a non-trivial steady state solution for the drop shape within the long wave approximation (lubrication theory), and we compare most of its features with experimental data. This solution is presented both in Cartesian and polar coordinates, whose constants must be determined by a certain group of measured parameters. Besides, we obtain the dynamics of the drop generation from numerical simulations of the full Navier-Stokes equation, where we emulate the hysteretic effects with an appropriate spatial distribution of the static contact angle over the substrate.

  20. A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps.

    Science.gov (United States)

    Kim, Dong-Young; Lee, Sun Hye; Carter, Roderick G; Kato, Atsushi; Schleimer, Robert P; Cho, Seong H

    2016-08-01

    Animal model systems are invaluable for examining human diseases. Our laboratory recently established a mouse model of nasal polyps (NPs) and investigated similarities and differences between this mouse model and human NPs. We especially focus on the hypothesis that B cell activation occurs during NP generation in the murine model. After induction of ovalbumin-induced allergic rhinosinusitis, 6% ovalbumin and Staphylococcus aureus enterotoxin B (10 ng) were instilled into the nasal cavity of mice three times per week for 8 weeks. The development of structures that somewhat resemble NPs (which we will refer to as NPs) was confirmed by hematoxylin and eosin staining. The mRNA and protein levels of various inflammatory cell markers and mediators were measured by real-time PCR in nasal tissue and by ELISA in nasal lavage fluid (NLF), respectively. Total Ig isotype levels in NLF were also quantitated using the Mouse Ig Isotyping Multiplex kit (EMD Millipore, Billerica, MA) on a Luminex 200 instrument (Life Technologies, Grand Island, NY). Similar to human NPs, there were significant increases in gene expression of inflammatory cell markers, such as CD19, CD138, CD11c, and mast cell protease-6 in nasal tissue samples of the NP group compared with those of the control group. In further investigations of B cell activation, mRNA expressions of B cell activating factor and a proliferation-inducing ligand were found to be significantly increased in mouse NP tissue. B cell-activating factor protein concentration and IgA and IgG1 levels in NLF were significantly higher in the NP group compared with the control group. In this study, the NP mouse model demonstrated enhanced B cell responses, which are reminiscent of B cell responses in human NPs. PMID:27163839

  1. Liquid Drop Measuring Device for Analyzing Liquid Properties

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Based on the correlation between certain properties of liquid and the properties of the corresponding liquid drop formed under given conditions, a liquid drop measuring device is utilized to monitor the drop formation process of the liquid sample with photoelectric measuring methods. The mechanical and optical characteristic of the liquid is explored with the optical fibers from the internal of the liquid drop during its formation. The drop head capacitor is utilized to monitor the growth process of the liquid drop to gain the drop volume information related to the physical property of liquid. The unique liquid drop trace containing the integrated properties of liquid is generated, and it is proved by experiment that for different liquids their liquid drop traces are different. The analysis on liquid properties and discrimination between different liquids can be proceeded with the liquid drop trace obtained by the liquid drop measuring device.

  2. Settling of copper drops in molten slags

    Science.gov (United States)

    Warczok, A.; Utigard, T. A.

    1995-02-01

    The settling of suspended metal and sulfide droplets in liquid metallurgical, slags can be affected by electric fields. The migration of droplets due to electrocapillary motion phenomena may be used to enhance the recovery of suspended matte/metal droplets and thereby to increase the recovery of pay metals. An experimental technique was developed for the purpose of measuring the effect of electric fields on the settling rate of metallic drops in liquid slags. Copper drops suspended in CaO-SiO2-Al2O3-Cu2O slags were found to migrate toward the cathode. Electric fields can increase the settling rate of 5-mm-diameter copper drops 3 times or decrease the settling until levitation by reversal of the electric field. The enhanced settling due to electric fields decreases with increasing Cu2O contents in the slag.

  3. Drop interaction with the ejecta sheet

    Science.gov (United States)

    Thoraval, M.-J.; Thoroddsen, S. T.; Takehara, K.; Etoh, T. G.; Ray, P.; Josserand, C.; Zaleski, S.

    2011-11-01

    We studied experimentally and numerically the dynamics of the ejecta sheet produced by a drop impacting on a deep pool of the same liquid at high Reynolds and Weber numbers. Ultra-high speed imaging revealed a diversity of evolutions by using different mixtures of water and glycerine, and different impact velocities. We observed a transition from a smooth ejecta sheet to a more irregular splashing for a Reynolds number of 3500. In this transition regime, the ejecta sheet interacts with the impacting drop. This interaction can pull the ejecta sheet towards the centre of the drop at lower splash parameters, or generate a bumping on the ejecta sheet moving outwards at higher splash parameters. The volume of fluid (VOF) code Gerris was used to reproduce numerically this peculiar dynamics in axisymmetric conditions. Very good agreement with the experiments was reached by using adaptive refinement and parallelization of the calculations.

  4. Effects of heated humidification and topical steroids on compliance, nasal symptoms, and quality of life in patients with obstructive sleep apnea syndrome using nasal continuous positive airway pressure.

    LENUS (Irish Health Repository)

    Ryan, Silke

    2012-02-01

    BACKGROUND: Nasal side effects are common in patients with obstructive sleep apnea syndrome (OSAS) starting on nasal continuous positive airway pressure (CPAP) therapy. We tested the hypothesis that heated humidification or nasal topical steroids improve compliance, nasal side effects and quality of life in this patient group. METHODS: 125 patients with the established diagnosis of OSAS (apnea\\/hypopnea index > or = 10\\/h), who tolerated CPAP via a nasal mask, and who had a successful CPAP titration were randomized to 4 weeks of dry CPAP, humidified CPAP or CPAP with additional topical nasal steroid application (fluticasone, GlaxoWellcome). Groups were similar in all demographic variables and in frequency of nasal symptoms at baseline. Outcome measures were objective compliance, quality of life (short form 36), subjective sleepiness (Epworth Sleepiness Scale score) and nasal symptoms such as runny, dry or blocked nose, sneezing and headaches; all variables assessed using a validated questionnaire and by direct interview. RESULTS: There was no difference in compliance between groups after 4 weeks (dry: 5.21 +\\/- 1.66 h\\/night, fluticasone: 5.66 +\\/- 1.68, humidifier: 5.21 +\\/- 1.84; p = 0.444). Quality of life and subjective sleepiness improved in all groups, but there were no differences in the extent of improvement. Nasal Symptoms were less frequently reported in the humidifier group (28%) than in the remaining groups (dry: 70%, fluticasone: 53%, p = 0.002). However, the addition of fluticasone resulted in increased frequency of sneezing. CONCLUSION: The addition of a humidifier, but not nasal steroids decreases the frequency of nasal symptoms in unselected OSAS patients initiating CPAP therapy; however compliance and quality of life remain unaltered.

  5. Short time dynamics of viscous drop spreading

    OpenAIRE

    Eddi, Antonin; Winkels, Koen G.; Snoeijer, Jacco H.

    2012-01-01

    Liquid drops start spreading directly after coming into contact with a solid sub- strate. Although this phenomenon involves a three-phase contact line, the spread- ing motion can be very fast. We experimentally study the initial spreading dy- namics, characterized by the radius of the wetted area, for viscous drops. Using high-speed imaging with synchronized bottom and side views gives access to 6 decades of time resolution. We show that short time spreading does not exhibit a pure power-law ...

  6. Shuttlecock Velocity of a Badminton Drop Shot

    Directory of Open Access Journals (Sweden)

    Ampharin Ongvises

    2013-12-01

    Full Text Available In a badminton ‘drop shot’, the shuttlecock is struck by a non-rotating racquet at low speed. In this investigation, a shuttlecock was hit by a badminton racquet in a linear collision, simulating a drop shot. The collision was recorded with high-speed video and the velocities of the racquet and shuttlecock determined. The relationship between the impact velocity of the racquet and the velocity of the shuttlecock as it leaves the badminton racquet after collision was found to be proportional over the range tested.

  7. Shuttlecock Velocity of a Badminton Drop Shot

    Directory of Open Access Journals (Sweden)

    Ampharin Ongvises

    2013-01-01

    Full Text Available In a badminton ‘drop shot’, the shuttlecock is struck by a non-rotating racquet at low speed. In this investigation, a shuttlecock was hit by a badminton racquet in a linear collision, simulating a drop shot. The collision was recorded with high-speed video and the velocities of the racquet and shuttlecock determined. The relationship between the impact velocity of the racquet and the velocity of the shuttlecock as it leaves the badminton racquet after collision was found to be proportional over the range tested.

  8. Drops on hydrophobic surfaces & vibrated fluid surfaces

    DEFF Research Database (Denmark)

    Wind-Willassen, Øistein

    in the literature. Furthermore, we quantify the energy associated with center of mass translation and internal fluid motion. The model predicts trajectories for tracer particles deposited inside the drop, and satisfactorily describes the sliding motion of steadily accelerating droplets. The model can be used...... the case where the fluid bath is also rotated around its center-line. The drop then experiences an effective Coriolis force, and previous studies have made a comparison between emerging unstable radii in this system and Landau levels for a charged particle in a magnetic field. The system is treated...

  9. 14 CFR 23.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 23.727... Construction Landing Gear § 23.727 Reserve energy absorption drop test. (a) If compliance with the reserve energy absorption requirement in § 23.723(b) is shown by free drop tests, the drop height may not be...

  10. Effects of nasalance on the acoustical properties of the tenor passaggio and the head voice

    Science.gov (United States)

    Perna, Nicholas Kevin

    This study aims to measure the effect that nasality has on the acoustical properties of the tenor passaggio and head voice. Not to be confused with forward resonance, nasality here will be defined as nasalance, the reading of a Nasometer, or the percentage of nasal and oral airflow during phonation. A previous study by Peer Birch et al. has shown that professional tenors used higher percentages of nasalance through their passaggio. They hypothesized that tenors used nasalance to make slight timbral adjustments as they ascended through passaggio. Other well respected authors including Richard Miller and William McIver have claimed that teaching registration issues is the most important component of training young tenors. It seemed logical to measure the acoustic effects of nasalance on the tenor passaggio and head voice. Eight professional operatic tenors participated as subjects performing numerous vocal exercises that demonstrated various registration events. These examples were recorded and analyzed using a Nasometer and Voce Vista Pro Software. Tenors did generally show an increase of nasalance during an ascending B-flat major scale on the vowels [i] and [u]. Perhaps the most revealing result was that six of seven tenors showed at least a 5-10% increase in nasalance on the note after their primary register transition on the vowel of [a]. It is suggested that this phenomenon receive further empirical scrutiny, because, if true, pedagogues could use nasalance as a tool for helping a young tenor ascend through his passaggio.

  11. An acoustic study of nasal consonants in three Central Australian languages.

    Science.gov (United States)

    Tabain, Marija; Butcher, Andrew; Breen, Gavan; Beare, Richard

    2016-02-01

    This study presents nasal consonant data from 21 speakers of three Central Australian languages: Arrernte, Pitjantjatjara and Warlpiri. The six nasals considered are bilabial /m/, dental /n/, alveolar /n/, retroflex /ɳ/, alveo-palatal /ɲ/, and velar /ŋ/. Nasal formant and bandwidth values are examined, as are the locations of spectral minima. Several differences are found between the bilabial /m/ and the velar /ŋ/, and also the palatal /ɲ/. The remaining coronal nasals /n n ɳ/ are not well differentiated within the nasal murmur, but their average bandwidths are lower than for the other nasal consonants. Broader spectral shape measures (Centre of Gravity and Standard Deviation) are also considered, and comparisons are made with data for stops and laterals in these languages based on the same spectral measures. It is suggested that nasals are not as easily differentiated using the various measures examined here as are stops and laterals. It is also suggested that existing models of nasal consonants do not fully account for the observed differences between the various nasal places of articulation; and that oral formants, in addition to anti-formants, contribute substantially to the output spectrum of nasal consonants. PMID:26936570

  12. Progress with volunteer studies of nasal deposition and clearance

    International Nuclear Information System (INIS)

    Inhalation is the main route of intake of radioactive material for workers, and can be an important pathway for members of the public following accidental releases of radioactivity to the environment. Much of the inhaled radioactivity initially deposits in the nose, typically over 40% for particles of aerodynamic diameter (dae) greater than 2 μm. However, there is remarkably little information on the clearance from the human nose of particles deposited during inhalation and, until now, none on the clearance of the significant fraction of material that remains in the nasal passage for more than 12 hours. NRPB is conducting a volunteer study to determine the effects of particle size and breathing pattern on particle deposition in, and clearance from, the human nasal passage. This article summarises results obtained to date. (author)

  13. Nasal fracture in sports: its occurrence and importance

    Directory of Open Access Journals (Sweden)

    Neide Pena Coto

    2010-07-01

    Full Text Available Introduction: The increasing number of participants in various sports,mainly those practiced indoors,brought a significant increase of orofacial injuries in sports,especially nasal fractures, which rank third in incidence in all sports.Objective and literature review: To study the causes, ccurrence and importance of nasal fracture in sports,as providing ways of protecting the maxillofacial area in sports is the responsibility of the dentist,area in which Sports Dentistry is establishing itself.Conclusion: A long athlete withdrawal carries great physical and psychological damage,as well as financial loss to his club.Attention in providing ways of protection for the athlete is required.

  14. Localized bi-nasal macular edema in optic chiasmal syndrome

    Directory of Open Access Journals (Sweden)

    Alejandro J Lavaque

    2013-01-01

    Full Text Available A 28-year-old healthy male complaining of vision loss in his right eye was discovered to have localized bi-nasal macular edema in the presence of a pituitary adenoma. The presence of a junctional scotoma composed by a central scotoma in the right eye associated with superior temporal quadrantanopia in the fellow eye was seen. The pattern detected in the visual field suggested the presence of an expansive mass at the level of the optic chiasm. Optical coherence tomography findings also revealed subtle macular thickness beyond normal in the superior and nasal quadrants of both maculae. This report illustrates the importance of suspecting a pituitary adenoma in the light of uncharacteristic retinal alterations.

  15. [Mensurement of airflow resistance in neonatal prongs of nasal CPAP

    Science.gov (United States)

    Sampietro, V I; Azevedo, M P; Resende, J G

    2000-01-01

    OBJECTIVE: To measure airflow resistance in prongs of nasal CPAP, making use of different gas admission flow (GAF) in the ventilation circuit, in different internal diameters of the nasal prongs, besides verifying whether a GAF responding only to the demand of three times the minute-volume(MV) is enough to the circuit not to be cause of CO(2) retention. METHODOLOGY: Nasal prongs, assembled in the original circuits, were used, having their prongs kept open to the atmosphere. Pressure was read at a pressure monitor, in water centimeters, connected to the appropriate entrance of the circuit. A flowmeter balanced to the pressure was used, gauged at 50 psi, installed to the oxygen net of the Hospital, connected to the assessing set of the CPAP circuit. Initially, making use of the 8 l/min flow and keeping the exhaling set of the circuit closed, it was possible to eliminate the nasal prongs larger than two once the measured resistance was equal to zero. Having nasal parts number zero, 1 and 2 selected for this study, the system was then assembled as for the neonate: the inhaling set to the gas source and the exhaling set sunk into different depths in the water seal (2, 4, 6 and 8 centimeters). At the level of patient analysis, in order to assess the CO(2) retention, a mechanical pulmonary ventilation device was used as gas source and a nasal CPAP circuit was assembled to the device in adequate places. GAF values and FiO(2) were determined in the commands of the mechanical ventilation device. The assessment of gas concentration in the ventilation circuit was made while assisting two newborns. Gas samples were obtained within the ventilation circuit in the system assessing set (samples A), and right after the distal prong to the gas entrance (samples B). To determine MV the Tidal Volume (considered 10ml/kg) was multiplied by the respiratory frequency of the patient; GAF was three times MV. RESULTS: To a maximum GAF of 8 litres/min, only prongs sized zero, 1 and 2 showed

  16. Mometasone furoate nasal spray for the treatment of asthma

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke

    2016-01-01

    INTRODUCTION: Asthma is a common respiratory disease characterized by airway inflammation, bronchoconstriction and airway hyperresponsiveness and symptoms such as coughing, wheezing, shortness of breath and chest tightness. Allergic rhinitis is a common comorbidity in asthma and glucocorticoids are...... associated with an improvement in asthma control. AREAS COVERED: This current paper reviews the current knowledge on the effect of mometasone furoate nasal spray in the treatment of asthma and includes clinical trials in which both subjective and objective outcomes are assessed. EXPERT OPINION: To date, only...... few clinical studies have investigated the effect of nasal steroids in the treatment of asthma. The studies investigating the effect of MFNS report contradicting results, although the most well-designed study to answer this question finds no improvement in asthma control. Thus, it seems unlikely that...

  17. Multifocal primary cutaneous extranodal NK/T lymphoma nasal type*

    Science.gov (United States)

    de Vasconcelos, Pedro; Ferreira, Cristina; Soares-Almeida, Luís; Filipe, Paulo

    2016-01-01

    Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old patient that came to our department with erythematous plaques of the right leg and eczematous lesions of the trunk. These lesions were biopsied and the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. He was treated with multi-agent systemic chemotherapy but died 5 months after diagnosis. This case highlights the rarity and variability of cutaneous features of this disease and its aggressive course and poor prognosis. PMID:27192524

  18. Local tissue hypoxia and formation of nasal polyps

    Institute of Scientific and Technical Information of China (English)

    姜舒; 董震; 朱冬冬; 杨占泉

    2003-01-01

    Objective To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP). Methods Epithelial cells of NP and inferior turbinate (IT) were cultured serum-fr ee under normal oxygen and hypoxic circumstances with stimulation of IL-1β and TNFα. The vascular endothelial growth factor (VEGF)mRNA and VEGF protein leve ls of the cultured cells were detected using in situ hybridization and ELISA, re spectively. Results The expression of VEGF mRNA was significantly higher in epithelial cells of NP t han in IT exposed to pro-inflammatory cytokines or hypoxia (P<0.01). VEGF levels were higher in NP epithelial cells than those of IT (P<0.01) under hypoxia.Conclusion VEGF-induced by hypoxia is very important for the early stages of forming polyps.

  19. MR findings of nasal cavity lesions showing the infundibular widening on

    Energy Technology Data Exchange (ETDEWEB)

    Youn, Eun Kyung; Lee, Young Uk; Lee, Young Rae [Kangbuk Samsung Hospital, Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of)

    1999-03-01

    Several kinds of nasal cavity lesions located in the region of the infundibulum on CT. At such time, the visualization of these lesions is very similar. The purpose of this study was to differentially diagnose these nasal cavity lesions through evaluation of the MR findings. In 51 cases of pathologically proven nasal cavity masses which on CT showed infundibular widening, we retrospectively evaluated the MR findings. The cases involved prolapsed antral mucosa from sinusitis(n=15), inverted papilloma(n=10), antrochoanal polyp(n=10), aspergillosis(n=9), and nasal polyp(n=7). All patients underwent both CT and MR. imaging. In all cases, CT findings were similar ; soft tissue masses filling the maxillary sinus and nasal cavity were associated with infundibular widening caused by pressure on the uncinate process, leading to erosion. Differential diagnosis by CT was very difficult ; MR T2 weighted imaging was most effective for differential diagnosis of these nasal cavity masses. Prolapsed antral mucosa showed central inhomogeneous mixed signal intensity, with a peripheral rim of hyperintensity along the sinus wall and nasal component. Antrochoanal polyps showed homogeneous bright signal intensity of the antral and nasal component. Aspergillosis showed central dark signal foci. Inverted papillomas showed mixed intermediate and high intensity mixed with high signal intensity. Nasal polyps showed striation mixed of intermediate and high signal intensity, while nasal polyp showed striation of intermediate and high intensity. On Gd-enhanced T1 weighted images, prolapsed antral mucosa and antrochoanal polyp showed peripheral rim enhancement of the antral and nasal component. In contrast, inverted papilloma and nasal polyp showed intense enhancement of the mass and can be separate from the sinus inflammatory disease. Various nasal cavity masses showing infundibular widening on CT can be differentiated on MR images, especially of these are T2 weighted or contrast enhanced T1

  20. Clinical effect of surgical correction for nasal pathology on the treatment of obstructive sleep apnea syndrome.

    Directory of Open Access Journals (Sweden)

    Chong Yoon Park

    Full Text Available OBJECTIVES: This study aimed to evaluate the hypothesis that relief of nasal obstruction in subjects with obstructive sleep apnea (OSA would lead to reduce OSA severity and to discuss the available evidence on the clinical efficacy of nasal surgery as a treatment modality for OSA. STUDY DESIGN: Twenty-five subjects who had reduced patency of nasal cavity and narrowing of retroglossal or retropalatal airways were diagnosed with OSA and underwent nasal surgery, such as septoplasty or turbinoplasty to correct nasal pathologies. The effect of the surgery on nasal patency was quantified by measuring minimal cross-sectional area (MCA using acoustic rhinometry. The watch-PAT-derived respiratory disturbance index (RDI, apnea and hypopnea index (AHI, lowest oxygen saturation, and valid sleep time were measured before and after nasal surgery. RESULTS: The present study shows that the AHI and RDI decreased significantly and the lowest oxygen saturation and valid sleep time rose after nasal surgery in 25 OSA subjects. In addition, a reduction in subjective symptoms was observed in subjects and mean MCA increased after nasal surgery. Fourteen subjects were classified as responders and 11 subjects as non-responders. Responders showed considerable improvement of their subjective symptoms and the AHI and RDI were significantly lower after surgery. We found that the changes between pre- and post-operative AHI and RDI values were minimal in 11 non-responders. However, daytime somnolence and REM sleep time improved after nasal surgery in non-responders. CONCLUSIONS: Our study provides evidence that the surgical treatment of nasal pathology improves nasal airway patency and reduces OSA severity in 56% subjects. Furthermore, correction of nasal pathology appears to result in improved sleep quality in both responder and non-responders OSA subjects.

  1. Drop impact entrapment of bubble rings

    CERN Document Server

    Thoraval, M -J; Etoh, T G; Thoroddsen, S T

    2012-01-01

    We use ultra-high-speed video imaging to look at the initial contact of a drop impacting onto a liquid layer. We observe experimentally the vortex street and the bubble-ring entrapments predicted numerically, for high impact velocities, by Thoraval et al. [Phys. Rev. Lett. 108, 264506 (2012)]. These dynamics occur mostly within 50 {\\mu}s after the first contact, requiring imaging at 1 million frames/sec. For a water drop impacting onto a thin layer of water, the entrapment of isolated bubbles starts through azimuthal instability, which forms at low impact velocities, in the neck connecting the drop and pool. For Re above about 12 000, up to 10 partial bubble-rings have been observed at the base of the ejecta, starting when the contact is about 20% of the drop size. More regular bubble rings are observed for a pool of ethanol or methanol. The video imaging shows rotation around some of these air cylinders, which can temporarily delay their breakup into microbubbles. The different refractive index in the pool l...

  2. 49 CFR 178.965 - Drop test.

    Science.gov (United States)

    2010-10-01

    ... Large Packaging design types and performed periodically as specified in § 178.955(e) of this subpart. (b... § 178.960(d). (d) Test method. (1) Samples of all Large Packaging design types must be dropped onto a... be restored to the upright position for observation. (2) Large Packaging design types with a...

  3. Reasons Students with Disabilities Drop Out.

    Science.gov (United States)

    Bounds, M. Betsy; Gould, Albert

    2000-01-01

    Students with disabilities who dropped out of high school (n=60) cited more school factors (lack of academic success, suspension, peer problems) than personal factors (motivation, pregnancy, family problems) influencing dropout. Three-fourths suggested improved communication with teachers, flexible scheduling, and more relevance would decrease…

  4. Scaling the drop size in coflow experiments

    Energy Technology Data Exchange (ETDEWEB)

    Castro-Hernandez, E; Gordillo, J M [Area de Mecanica de Fluidos, Universidad de Sevilla, Avenida de los Descubrimientos s/n, 41092 Sevilla (Spain); Gundabala, V; Fernandez-Nieves, A [School of Physics, Georgia Institute of Technology, Atlanta, GA 30332 (United States)], E-mail: jgordill@us.es

    2009-07-15

    We perform extensive experiments with coflowing liquids in microfluidic devices and provide a closed expression for the drop size as a function of measurable parameters in the jetting regime that accounts for the experimental observations; this expression works irrespective of how the jets are produced, providing a powerful design tool for this type of experiments.

  5. As Fitness Levels Rise, Diabetes Risk Drops

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_158889.html As Fitness Levels Rise, Diabetes Risk Drops But change requires dedication to regular exercise in the long run, study shows ... By Robert Preidt Tuesday, May 17, 2016 TUESDAY, May 17, 2016 (HealthDay News) -- A higher level of heart-lung fitness may reduce your risk ...

  6. Predicting Students Drop Out: A Case Study

    Science.gov (United States)

    Dekker, Gerben W.; Pechenizkiy, Mykola; Vleeshouwers, Jan M.

    2009-01-01

    The monitoring and support of university freshmen is considered very important at many educational institutions. In this paper we describe the results of the educational data mining case study aimed at predicting the Electrical Engineering (EE) students drop out after the first semester of their studies or even before they enter the study program…

  7. Utah Drop-Out Drug Use Questionnaire.

    Science.gov (United States)

    Governor's Citizen Advisory Committee on Drugs, Salt Lake City, UT.

    This questionnaire assesses drug use practices in high school drop-outs. The 79 items (multiple choice or apply/not apply) are concerned with demographic data and use, use history, reasons for use/nonuse, attitudes toward drugs, availability of drugs, and drug information with respect to narcotics, amphetamines, LSD, Marijuana, and barbiturates.…

  8. Peak nasal inspiratory flow: uma possível ferramenta para a motricidade orofacial? Peak nasal inspiratory flow: a possible instrument in orofacial myology?

    Directory of Open Access Journals (Sweden)

    Andréa Rodrigues Motta

    2010-12-01

    Full Text Available Os fonoaudiólogos que atuam no campo da Motricidade Orofacial atendem com frequência, pacientes com obstrução nasal; entretanto, nem sempre o acesso ao profissional responsável pelo diagnóstico otorrinolaringológico é fácil. O Peak Nasal Inspiratory Flow é um instrumento barato, de fácil manuseio, amplamente citado na literatura internacional, que tem por objetivo avaliar a patência nasal. O objetivo do presente estudo foi realizar uma revisão da literatura acerca do Peak Nasal Inspiratory Flow, fornecendo subsídios para reflexões acerca de seu emprego nos distúrbios miofuncionais orofaciais e cervicais. Para tanto, foi realizada uma revisão da literatura nas bases de dados Medline, Cochrane Library, LILACS e SciELO empregando-se os descritores peak, inspiratory, nasal e flow. O Peak Nasal Inspiratory Flow mostrou-se uma técnica simples, barata, validada e com boa reprodutibilidade. Parece, portanto, tratar-se de um instrumento útil para avaliação da patência nasal, apesar de algumas limitações, fornecendo dados complementares ao diagnóstico miofuncional orofacial e cervical. Entretanto, estudos clínicos precisam ser conduzidos para que se comprove ou refute a hipótese.The speech-language pathologists that work in the Orofacial Myology field frequently have patients with nasal obstruction; however, the access to the professional responsible for the diagnosis can be difficult at times. The Peak Nasal Inspiratory Flow is a cheap and easy to handle instrument, broadly cited in the international literature, that has the aim to evaluate nasal patency. The aim of this study was to review the current literature regarding the Peak Nasal Inspiratory Flow, enabling considerations about its use in cervical and orofacial myology disorders. The literature review consulted Medline, Cochrane Library, LILACS and SciELO databases, using the keywords: peak, inspiratory, nasal and flow. The results showed that Peak Nasal Inspiratory Flow

  9. CHONDROID CHORDOMA OF NASAL SEPTUM : A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Gayattre

    2015-04-01

    Full Text Available Chordomas are rare neoplasms of presumed notochordal origin that arise along the vertebral axis and show a proclivity for the spheno - occipital and sacral regions. ( 1,2 Chondroid chordoma is a variant of chordoma, with cartilaginous component . We report a histologically proven case of chondroid chordoma, with an exceptional localization to the nasal septum . Chondroid Chordomas are likely to recur and hence diagnostically important to institute effective treatment .

  10. CAPILLARY HEMANGIOMA OF THE NASAL SEPTUM IN CHILDREN

    OpenAIRE

    Salman, Nergis; Baysal, Nakiye; Adabag, Aysegul; Yildiz, Ugur; Akin, Istemihan

    2012-01-01

    Lobular capillary hemangioma (LCH) is a benign vascular tumor, also known as, pyogenic granuloma. LCH appears on the skin, the oral mucosa, and, rarely, on the nasal mucosa. Trauma, hormones, viral oncogenes, microscopic arteriovenous malformations, and angiogenic growth factors have been implicated in the etiology of LCH lesions. LCH most commonly presents in the third decade of life but may present in persons of any age. It is considerably rare in children; only a few cases have been report...

  11. [Nasal obstruction and mouth breathing: the ENT's point of view].

    Science.gov (United States)

    Leboulanger, Nicolas

    2013-06-01

    Obstructive diseases of children's upper airways are frequent, mostly caused by tonsils and adenoids hypertrophy. A nasal septum deviation or a lower turbinate hypertrophy may also cause a significant obstruction. Tonsillectomy and adenoidectomy must be performed in case of clinical obstruction, sometimes documented by a sleep study. A tonsils' hypertrophy without significant obstruction and clinical symptoms is not an indication of adenotonsillectomy, even in case of snoring or if an orthodontic treatment is planned.

  12. Primary Burkitt's Lymphoma in the Nasal Cavity and Paranasal Sinuses

    OpenAIRE

    Lee, Dong Hwan; Yu, Myeong Sang; Lee, Bong-Jae

    2013-01-01

    Burkitt's lymphoma is a highly aggressive small B-cell lymphoma. The treatment of choice is complex chemotherapy. As a rare tumor in the head and neck area, Burkitt's lymphoma usually involves cervical lymph nodes, and only fewer than 25% of cases involves extranodal regions. Involvement of the paranasal sinuses has been reported in only 14 cases in the past century. We describe here two patients with rare, sporadic, American type Burkitt's lymphoma involving the nasal cavity and paranasal si...

  13. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists

    Directory of Open Access Journals (Sweden)

    Tereza C.S. Brant

    2014-01-01

    Full Text Available OBJECTIVES: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. METHODS: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2 concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039. RESULTS: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m3 for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p = 0.036. CONCLUSION: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.

  14. Carotid Cavernous Fistula Subsequent to Nasal Septoplasty; A Case Report

    Directory of Open Access Journals (Sweden)

    H Moin

    2005-03-01

    Full Text Available Carotid cavernous fistula (CCF is a rare and lethal condition; it can be spontaneous, traumatic or iatrogenic. This report Presents a case of CCF subsequent to nasal septoplasty who was a 24 years old lady with proptosis and severe decreased visual acuity. After cerebral angiography, trapping and embolization of fistula was performed with good recovery. Like our case, review of articles shows that the patients are signs and symptoms free after embolization.

  15. Saccade performance in the nasal and temporal hemifields

    DEFF Research Database (Denmark)

    Jóhannesson, Ómar Ingi; Ásgeirsson, Árni Gunnar; Kristjánsson, Árni

    2012-01-01

    There are numerous asymmetries in anatomy between the nasal and temporal hemiretinae, which have been connected to various asymmetries in behavioral performance. These include asymmetries in Vernier acuity, saccade selection, and attentional function, in addition to some evidence for latency diff...... is surprising in light of previous findings of attentional asymmetries, it may reflect that cortical input to midbrain eye control centers mitigates any retinal and retinotectal asymmetry....

  16. Ameloblastoma de fossa nasal: revisão bibliográfica e relato de dois casos Nasal ameloblastoma: literature review and report of two cases

    Directory of Open Access Journals (Sweden)

    Washington L. C. Almeida

    2001-09-01

    Full Text Available O ameloblastoma é um tumor bastante incomum na cavidade nasal. Surge a partir do epitélio odontogênico, podendo estender-se ao seio maxilar, órbitas e base de crânio. Apresentamos dois casos de ameloblastoma em fossa nasal direita, associados a sintomas nasossinusais e seus principais achados, clínicos e cirúrgicos.Ameloblastoma is a very unusual tumor in the nasal cavity. It arises from the odontogenic epithelium and extends up to the maxillary sinus, orbits and skull base. We have presented two cases of ameloblastoma, both in the right nasal cavity, associated with nasal and sinusal symptoms, and reported the main surgical and clinical findings.

  17. Numerical investigation of the influence of companion drops on drop-on-demand ink jetting

    Institute of Scientific and Technical Information of China (English)

    Hai-yun ZHANG; Jin WANG; Guo-dong LU

    2012-01-01

    In this study we characterized and investigated the specific phenomenon of “companion drops” in the drop-ondemand (DOD) ink jetting process.A series of simulations based on a piezoelectric DOD printhead system is presented,adapting the volume-of-fluid (VOF) interface-capturing method to track the boundary evolution and model the interfacial physics.The results illustrate the causality between the generation of companion drops and droplet deviation behavior,as well as their close correlations with ink jetting straightness and printing accuracy.The characteristics of companion drops are summarized and compared with those of satellite drops.Also,a theoretical mechanism for the generation of companion drops is presented,and their effects and behaviors are analyzed and discussed.Finally,the effects of critical factors on the generation of companion drops are investigated and characterized based on variations in the printable pressure range.Recommendations are given for the suppression of companion drops and for the improvement of printing accuracy.

  18. Failure patterns following cobalt irradiation in dogs with nasal carcinoma

    International Nuclear Information System (INIS)

    The pattern of tumor recurrence was assessed in 24 dogs receiving cobalt radiation therapy for nasal carcinoma. Dogs were evaluated using nasal cavity computed tomography prior to treatment, and at 1, 3, 6 and 12 months after treatment, and at 6-month intervals thereafter if still alive. Dogs were treated with various combinations of total dose, and fraction size. Total doses were normalized to equivalent doses given in 3.0 Gy fractions. The extent of tumor regression or duration of tumor control were not dependent on absolute total dose, normalized total dose, or tumor type. The median duration of local control in all dogs was 312 days. Marked tumor regression was observed in 11 of the 24 dogs. Median duration of local control was significantly longer in dogs with marked tumor regression in comparison to dogs without tumor regression; 389 vs. 161 days respectively. When tumor recurrence was documented in dogs having tumor regression, the location of the recurrence was in the nasal cavity. No tumor recurred in a sinus or periorbital region, and only one geographic miss was detected. Tumor recurrence in the irradiated volume, including dogs with and without marked regression, was documented in 13 of the 24 dogs. The high local failure rate, coupled with the recurrence pattern in these dogs, suggests there may be an opportunity for improvement in local control through use of shrinking field techniques

  19. Is the human nasal cavity at risk from inhaled radionuclides?

    International Nuclear Information System (INIS)

    In a series of three life-span studies in which beagle dogs inhaled relatively soluble forms of beta-emitting radionuclides, a number of cancers of the nasal cavity have arisen at long times after the inhalation exposure. No such cancers were observed in the control dogs. Data obtained in other studies involving serial sacrifice of dogs that received these radionuclides in similar forms have shown that high local concentrations of the radionuclides can persist in nasal turbinates for long periods of time, depending on the physical half-life of the radionuclide inhaled. Several nasal carcinomas have also been observed in dogs injected with 137CsCl in which the relative concentrations of beta activity in the turbinate region were not as pronounced as in the above studies. Similar risks of sinonasal cancer were calculated for dogs in each of these studies regardless of differences in radionuclide, dosimetry, and route of administration. Since sinonasal cancers have occurred in people exposed to alpha-emitting radionuclides, it is reasonable to assume this could occur with beta emitters as well. Radiation protection guidelines should account for the sinonasal region being at risk. 23 refs., 1 fig., 6 tabs

  20. Nasal Septal Deviations: A Systematic Review of Classification Systems

    Science.gov (United States)

    Teixeira, Jeffrey; Certal, Victor; Chang, Edward T.; Camacho, Macario

    2016-01-01

    Objective. To systematically review the international literature for internal nasal septal deviation classification systems and summarize them for clinical and research purposes. Data Sources. Four databases (including PubMed/MEDLINE) were systematically searched through December 16, 2015. Methods. Systematic review, adhering to PRISMA. Results. After removal of duplicates, this study screened 952 articles for relevance. A final comprehensive review of 50 articles identified that 15 of these articles met the eligibility criteria. The classification systems defined in these articles included C-shaped, S-shaped, reverse C-shaped, and reverse S-shaped descriptions of the septal deviation in both the cephalocaudal and anteroposterior dimensions. Additional studies reported use of computed tomography and categorized deviation based on predefined locations. Three studies graded the severity of septal deviations based on the amount of deflection. The systems defined in the literature also included an evaluation of nasal septal spurs and perforations. Conclusion. This systematic review ascertained that the majority of the currently published classification systems for internal nasal septal deviations can be summarized by C-shaped or reverse C-shaped, as well as S-shaped or reverse S-shaped deviations in the anteroposterior and cephalocaudal dimensions. For imaging studies, predefined points have been defined along the septum. Common terminology can facilitate future research. PMID:26933510

  1. Nasal Septal Deviations: A Systematic Review of Classification Systems

    Directory of Open Access Journals (Sweden)

    Jeffrey Teixeira

    2016-01-01

    Full Text Available Objective. To systematically review the international literature for internal nasal septal deviation classification systems and summarize them for clinical and research purposes. Data Sources. Four databases (including PubMed/MEDLINE were systematically searched through December 16, 2015. Methods. Systematic review, adhering to PRISMA. Results. After removal of duplicates, this study screened 952 articles for relevance. A final comprehensive review of 50 articles identified that 15 of these articles met the eligibility criteria. The classification systems defined in these articles included C-shaped, S-shaped, reverse C-shaped, and reverse S-shaped descriptions of the septal deviation in both the cephalocaudal and anteroposterior dimensions. Additional studies reported use of computed tomography and categorized deviation based on predefined locations. Three studies graded the severity of septal deviations based on the amount of deflection. The systems defined in the literature also included an evaluation of nasal septal spurs and perforations. Conclusion. This systematic review ascertained that the majority of the currently published classification systems for internal nasal septal deviations can be summarized by C-shaped or reverse C-shaped, as well as S-shaped or reverse S-shaped deviations in the anteroposterior and cephalocaudal dimensions. For imaging studies, predefined points have been defined along the septum. Common terminology can facilitate future research.

  2. CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.

    Science.gov (United States)

    Sinha, Ian P; McBride, Antonia K S; Smith, Rachel; Fernandes, Ricardo M

    2015-09-01

    Severe respiratory failure develops in some infants with bronchiolitis because of a complex pathophysiologic process involving increased airways resistance, alveolar atelectasis, muscle fatigue, and hypoxemia due to mismatch between ventilation and perfusion. Nasal CPAP and high-flow nasal cannula (HFNC) oxygen may improve the work of breathing and oxygenation. Although the mechanisms behind these noninvasive modalities of respiratory support are not well understood, they may help infants by way of distending pressure and delivery of high concentrations of warmed and humidified oxygen. Observational studies of varying quality have suggested that CPAP and HFNC may confer direct physiologic benefits to infants with bronchiolitis and that their use has reduced the need for intubation. No trials to our knowledge, however, have compared CPAP with HFNC in bronchiolitis. Two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Two trials evaluated HFNC in bronchiolitis (one comparing it with headbox oxygen, the other with nebulized hypertonic saline), with the results not seeming to suggest important clinical or physiologic benefits. In this article, we review the pathophysiology of respiratory failure in bronchiolitis, discuss these trials in detail, and consider how future research studies may be designed to best evaluate CPAP and HFNC in bronchiolitis. PMID:25836649

  3. CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.

    Science.gov (United States)

    Sinha, Ian P; McBride, Antonia K S; Smith, Rachel; Fernandes, Ricardo M

    2015-09-01

    Severe respiratory failure develops in some infants with bronchiolitis because of a complex pathophysiologic process involving increased airways resistance, alveolar atelectasis, muscle fatigue, and hypoxemia due to mismatch between ventilation and perfusion. Nasal CPAP and high-flow nasal cannula (HFNC) oxygen may improve the work of breathing and oxygenation. Although the mechanisms behind these noninvasive modalities of respiratory support are not well understood, they may help infants by way of distending pressure and delivery of high concentrations of warmed and humidified oxygen. Observational studies of varying quality have suggested that CPAP and HFNC may confer direct physiologic benefits to infants with bronchiolitis and that their use has reduced the need for intubation. No trials to our knowledge, however, have compared CPAP with HFNC in bronchiolitis. Two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Two trials evaluated HFNC in bronchiolitis (one comparing it with headbox oxygen, the other with nebulized hypertonic saline), with the results not seeming to suggest important clinical or physiologic benefits. In this article, we review the pathophysiology of respiratory failure in bronchiolitis, discuss these trials in detail, and consider how future research studies may be designed to best evaluate CPAP and HFNC in bronchiolitis.

  4. Balloon sinuplasty: a new concept in the endoscopic nasal surgery

    Directory of Open Access Journals (Sweden)

    Nogueira Júnior, João Flávio

    2008-12-01

    Full Text Available Introduction: Sinus diseases affect millions of people annually. Clinical treatment is effective in most patients, but in case of failure of this therapy the functional endoscopic surgery is currently the treatment choice for surgical treatment. The objective of the functional endoscopic surgery is to increase the aeration and drainage of the involved paranasal sinuses, which allows for the adequate functioning of the nasal mucosa mucociliary clearance. However, this method still has some limitations, mainly because it removes the nasal mucosa and bone tissue, and it may lead to physiologic alterations of the nasosinusal mucosa and cicatricial fibrosis. Many of these patients could be benefited from less invasive methods, with larger nasal mucosa preservation. Since 2006, an even less invasive procedure was remarked in our specialty: the balloon dilatation of the paranasal sinus ostia. Objective: The objective of this article is to define the concept of sinuplasty, its action mechanism, and present the necessary material for the procedures performance; to describe the techniques with the equipment in a nasosinusal endoscopic surgery simulator model and review the current literature about the indications, complications, results, and follow-up of patients submitted to this procedure. Balloon sinuplasty is safe and appears to be effective in the improvement of the quality of life of patients not responsive to conventional clinical therapy. New applications and indications for this equipment should be described and researched.

  5. The Healthy Infant Nasal Transcriptome: A Benchmark Study

    Science.gov (United States)

    Chu, Chin-Yi; Qiu, Xing; Wang, Lu; Bhattacharya, Soumyaroop; Lofthus, Gerry; Corbett, Anthony; Holden-Wiltse, Jeanne; Grier, Alex; Tesini, Brenda; Gill, Steven R.; Falsey, Ann R.; Caserta, Mary T.; Walsh, Edward E.; Mariani, Thomas J.

    2016-01-01

    Responses by resident cells are likely to play a key role in determining the severity of respiratory disease. However, sampling of the airways poses a significant challenge, particularly in infants and children. Here, we report a reliable method for obtaining nasal epithelial cell RNA from infants for genome-wide transcriptomic analysis, and describe baseline expression characteristics in an asymptomatic cohort. Nasal epithelial cells were collected by brushing of the inferior turbinates, and gene expression was interrogated by RNA-seq analysis. Reliable recovery of RNA occurred in the absence of adverse events. We observed high expression of epithelial cell markers and similarity to the transcriptome for intrapulmonary airway epithelial cells. We identified genes displaying low and high expression variability, both inherently, and in response to environmental exposures. The greatest gene expression differences in this asymptomatic cohort were associated with the presence of known pathogenic viruses and/or bacteria. Robust bacteria-associated gene expression patterns were significantly associated with the presence of Moraxella. In summary, we have developed a reliable method for interrogating the infant airway transcriptome by sampling the nasal epithelium. Our data demonstrates both the fidelity and feasibility of our methodology, and describes normal gene expression and variation within a healthy infant cohort. PMID:27658638

  6. Sulforaphane induces SLPI secretion in the nasal mucosa

    Science.gov (United States)

    Meyer, Megan; Kesic, Matthew J.; Clarke, John; Ho, Emily; Simmen, Rosalia C.M.; Diaz-Sanchez, David; Noah, Terry L.; Jaspers, Ilona

    2012-01-01

    Summary Cells lining the respiratory tract are equipped with mechanisms that dampen the effects of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a mediator involved in regulating oxidative stress. Recent data indicate Nrf2 also controls expression of secretory leukocyte protease inhibitor (SLPI). Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, enhances Nrf2 activity. Therefore, we hypothesized that SFN supplementation induces SLPI secretion in the nasal mucosa in an Nrf2 dependent manner. Healthy nonsmoking adults ingested SFN-containing broccoli shake homogenate (BSH) for 3 consecutive days. Nasal lavage fluid (NLF) was collected before and after BSH ingestion and analyzed for SLPI protein levels. In follow up in vitro experiments, differentiated primary nasal epithelial cells were used to evaluate the relationship between SFN, Nrf2, and SLPI. Epithelial cells were transduced with Nrf2-specific shRNA to examine the regulatory role of Nrf2 on SLPI expression. Supplementation with BSH significantly increased SLPI levels in NLF. SFN supplementation in vitro significantly enhanced SLPI secretion and these effects were significantly decreased in cells transduced with Nrf2-specific shRNA. PMID:23195333

  7. Proteomic analysis of nasal epithelial cells from cystic fibrosis patients.

    Directory of Open Access Journals (Sweden)

    Ludovic Jeanson

    Full Text Available The pathophysiology of cystic fibrosis (CF lung disease remains incompletely understood. New explanations for the pathogenesis of CF lung disease may be discovered by studying the patterns of protein expression in cultured human nasal epithelial cells (HNEC. To that aim, we compared the level of protein expressions in primary cultures of HNEC from nasal polyps secondary to CF (CFNP, n = 4, primary nasal polyps (NP, n = 8 and control mucosa (CTRL, n = 4 using isobaric tag for relative and absolute quantification (iTRAQ labeling coupled with liquid chromatography (LC-MS-MS. The analysis of the data revealed 42 deregulated protein expressions in CFNP compared to NP and CTRL, suggesting that these alterations are related to CF. Overall, AmiGo analysis highlighted six major pathways important for cell functions that seem to be impaired: metabolism, G protein process, inflammation and oxidative stress response, protein folding, proteolysis and structural proteins. Among them, glucose and fatty acid metabolic pathways could be impaired in CF with nine deregulated proteins. Our proteomic study provides a reproducible set of differentially expressed proteins in airway epithelial cells from CF patients and reveals many novel deregulated proteins that could lead to further studies aiming to clarify the involvement of such proteins in CF pathophysiology.

  8. Annual Occurrence of Meteorite-Dropping Fireballs

    Science.gov (United States)

    Konovalova, Natalia; Jopek, Tadeusz J.

    2016-07-01

    The event of Chelyabinsk meteorite has brought about change the earlier opinion about limits of the sizes of potentially dangerous asteroidal fragments that crossed the Earth's orbit and irrupted in the Earth's atmosphere making the brightest fireball. The observations of the fireballs by fireball networks allows to get the more precise data on atmospheric trajectories and coordinates of predicted landing place of the meteorite. For the reason to search the periods of fireball activity is built the annual distribution of the numbers of meteorites with the known fall dates and of the meteorite-dropping fireballs versus the solar longitude. The resulting profile of the annual activity of meteorites and meteorite-dropping fireballs shows several periods of increased activity in the course of the year. The analysis of the atmospheric trajectories and physical properties of sporadic meteorite-dropping fireballs observed in Tajikistan by instrumental methods in the summer‒autumn periods of increased fireballs activity has been made. As a result the structural strength, the bulk density and terminal mass of the studied fireballs that can survive in the Earth atmosphere and became meteorites was obtained. From the photographic IAU MDC_2003 meteor database and published sources based on the orbit proximity as determined by D-criterion of Southworth and Hawkins the fireballs that could be the members of group of meteorite-dropping fireballs, was found. Among the near Earth's objects (NEOs) the searching for parent bodies for meteorite-dropping fireballs was made and the evolution of orbits of these objects in the past on a long interval of time was investigated.

  9. Experience in the management of patients with nasal fractures. Experiencia en el manejo de los pacientes con fracturas nasales.

    Directory of Open Access Journals (Sweden)

    Jorge Luis Estepa Pérez

    2009-03-01

    Full Text Available Background: Nasal fracture is the most frequent facial trauma; its immediate treatment help avoiding further complications. Objective: to characterize the patients with nasal fracture who meet the criteria for treatment. Method: An observational, descriptive study was developed, including all patients (114 of 15 years or more with nasal fracture received at the Emergency Maxilo-Facial Surgical Department in the provincial hospital of Cienfuegos from June 2006 to April 2007. The studies variables were age, sex, aetiology, clinical signs, classification depending on the fractures focus and direction of the trauma, treatment following the guidelines for good clinical practices and post-treatment assessment. Results: There was higher incidence of males and the age group between 15 and 44. The main cause of fracture were fights, the most frequent clinical sign was epistaxis. The most common fractures were closed fractures and lateral deviation fractures. Most of the patients received immediate treatment. Among the clinical postsurgical sing was nasal congestion. Conclusions: We proved that immediate care should be provided to patients with this kind of fractures with local anaesthesia to avoid further risks.Fundamento: La fractura nasal constituye el trauma más frecuente del macizo facial, tratarlas de forma inmediata evita complicaciones al paciente. Objetivo: Caracterizar los pacientes con fracturas nasales tributarios a tratamiento. Método: Se realizó un estudio observacional descriptivo que incluyó todos los pacientes (114 con 15 años de edad o más y que fueron atendidos con el diagnóstico de fractura nasal en el Servicio de Urgencias de Cirugía Máxilofacial del Hospital Provincial de Cienfuegos, en el período de junio 2006 a abril del 2007. Las variables estudiadas fueron edad, sexo, etiología, signos

  10. [The possibility of using соformulated intranasal drugs after surgical correction of nasal breathing].

    Science.gov (United States)

    Nikiforova, G N; Svistushkin, V M; Zakharova, N M; Shevchik, E A; Zolotova, A V; Dedova, M G

    2016-01-01

    One of the major causes of chronic nasal obstruction is the nasal septum deformation and increase of the lower nasal turbinates. The number of septoplasty--operations ranges from 14% to 44,2% of all ENT-operations. The results of surgery are swelling of the tissues and damaged ciliar epithelium, that leads to the inparament of the mucociliar transport. In the postoperati e period the nasal cavity should be cleaned. Drugs, that are used, should reduce swelling, improve regeneration and should not supress ciliar activity. The results of supervisory, non-interventional study have shown, that application of Nasiс after septoplasty and submucose vasotomy of inferior nasal turbinates increases reparative process and leads to more rapid recovery of respiratory function of nasal cavity. PMID:26977570

  11. Use of high-flow nasal cannula in neonates: Nationwide survey in Japan.

    Science.gov (United States)

    Motojima, Yukiko; Ito, Masato; Oka, Shuntaro; Uchiyama, Atsushi; Tamura, Masanori; Namba, Fumihiko

    2016-04-01

    High-flow nasal cannula is a new modality of respiratory support and is increasing in popularity despite the lack of supporting evidence. We investigated the prevalence of its use in tertiary neonatal units in Japan. A paper-based survey was conducted. The response rate was 83%. High-flow nasal cannula was used in 46/80 units (58%), of which 96% used the high-flow nasal cannula without guidelines. It was used for several indications, including weaning off nasal continuous positive airway pressure and post-extubation respiratory support. The main perceived benefits of the cannula included better access to the neonate and reduced risk of nasal trauma. This survey found that high-flow nasal cannula is used without clear criteria and that clinical practice varies across neonatal units in Japan. Its use in neonates needs to be urgently evaluated. PMID:27095676

  12. Role of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps

    Science.gov (United States)

    Xu, Jun; Han, Ruining; Kim, Dae Woo; Mo, Ji-Hun; Jin, Yongde; Rha, Ki-Sang; Kim, Yong Min

    2016-01-01

    Background and Objectives Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. The dysregulation of IL-10 is associated with an enhanced immunopathologic response to infection, as well as with an increased risk for developing numerous autoimmune diseases. In this study, we investigated IL-10 expression in chronic rhinosinusitis with nasal polyps (CRSwNP) and assessed the possible role of IL-10 in the pathogenesis of CRSwNP. Materials and Methods Thirty-five patients with CRSwNP, 12 patients with chronic rhinosinusitis without NP (CRSsNP) and 10 control subjects were enrolled in this study. NP tissues and uncinated tissues (UT) were collected for analysis. Dispersed NP cells (DNPCs) were cultured in the presence or absence of IL-25 and IL-10, and a flow cytometric assay was performed to identify the constitutive cell populations of the DNPCs. Murine NP (n = 18) models were used for the in vivo experiments. Real-time PCR, immunohistochemistry, western blotting analysis and ELISA were performed to measure the expression levels of the selected inflammatory cytokines and inflammation-associated molecules. Results The mRNA expression levels of IL-10, IL-5, IL-17A, IL-25 and interferon gamma (IFN-γ) were significantly higher in the NP tissues than in the UT tissues. Strong positive correlations were observed between IL-10 and a variety of inflammatory cytokines (IL-5, IL-17A, IL-25, IFN-γ) and inflammation-associated molecules (B-cell activating factor; BAFF, CD19). Other than the IL-25 to IL-10 ratio, the expression ratios of the other measured inflammatory cytokines to IL-10 were significantly lower in the CRSwNP group than in the CRSsNP or control groups. Administrating IL-25 into the cultured DNPCs significantly increased the production of IL-10, but administrating IL-10 had no effect on the production of IL-25. Conclusion Increased expression of IL-10, IL-10 related inflammatory cytokine, and IL-10 related B cell activation indicated that IL-10, a potent

  13. Determination of the Effect of Nasal Septoplasty on Pulmonary Artery Pressure in Patients with Deviated Nasal Septum

    Directory of Open Access Journals (Sweden)

    Ghazipour

    2014-07-01

    Full Text Available Background Nasal septal deviation (NSD can cause upper airway obstruction, which results in hypoxia and therefore, pulmonary vasoconstriction, ventricular hypertrophy and right-sided heart failure. Objectives The aim of this study is to determine the mean pulmonary arterial pressure (mPAP of the patients with NSD and the effect of septoplasty on pulmonary arterial pressure. Patients and Methods Thirty five patients with NSD (mean age, 31.37 years; 19 men and 16 women were included in the study. Mean pulmonary arterial pressure was measured in the preoperative period and after third month postsurgery. Results The preoperative mPAP value (23.43 mmHg [SD, 3.84] was higher than postoperative values (20.17 mmHg [SD, 3.36]. There was a significant decrease in mPAP after the surgery (3.26 mmHg. P-value in our study was smaller than 0.001. Conclusions Nasal septal deviation like other causes of upper airway obstruction such as adenotonsillar hypertrophy affects mPAP. Nasal septoplasty is effective in reduction of mPAP in patients with NSD.

  14. Coalescence collision of liquid drops I: Off-center collisions of equal-size drops

    Directory of Open Access Journals (Sweden)

    Alejandro Acevedo-Malavé

    2011-09-01

    Full Text Available The Smoothed Particle Hydrodynamics method (SPH is used here to model off-center collisions of equal-size liquid drops in a three-dimensional space. In this study the Weber number is calculated for several conditions of the droplets dynamics and the velocity vector fields formed inside the drops during the collision process are shown. For the permanent coalescence the evolution of the kinetic and internal energy is shown and also the approaching to equilibrium of the resulting drop. Depending of the Weber number three possible outcomes for the collision of droplets is obtained: permanent coalescence, flocculation and fragmentation. The fragmentation phenomena are modeled and the formation of small satellite drops can be seen. The ligament that is formed follows the “end pinching” mechanism and it is transformed into a flat structure.

  15. Metaplastic changes of nasal respiratory epithelium in rats exposed to hexamethylphosphoramide (HMPA) by inhalation.

    OpenAIRE

    K. P. Lee(University of Tokyo); Trochimowicz, H. J.

    1982-01-01

    Rats exposed by inhalation to hexamethylphosphoramide (HMPA) at concentrations of 50, 100, 400, and 4000 parts per billion (ppb) for 6-24 months revealed nasal tumors and squamous metaplasia with inflammation in the nasal epithelium, but no changes were observed at 10 ppb. The ciliated cells were most susceptible to HMPA, showing degenerative changes, with abnormal cilia and extensive deciliation. The desquamated nasal epithelium was repaired initially by undifferentiated mucus or microvillou...

  16. Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde.

    OpenAIRE

    Holmstrom, M.; Lund, V J

    1991-01-01

    Formaldehyde is a well known nasal carcinogen in rodents, but so far there has been no convincing evidence that workers occupationally exposed to formaldehyde have an increased risk of nasal cancer. In this study three cases of malignant melanoma of the nasal mucosa in persons occupationally exposed to formaldehyde for a long time are presented. The occurrence of such a rare tumour in patients with significant exposure to a known carcinogen warrants further investigation.

  17. Risk factors for Staphylococcus aureus nasal colonization in Danish middle-aged and elderly twins

    DEFF Research Database (Denmark)

    Andersen, P S; Larsen, Lisbeth Aagaard; Fowler, V G;

    2013-01-01

    Staphylococcus aureus is a human commensal bacterium found in the nasal cavity and other body sites. Identifying risk factors for S. aureus nasal carriage is of interest, as nasal carriage is a risk factor for subsequent invasive infection. We recently investigated the influence of host genetics ......, male gender, psoriasis, and atopic diseases. Also, present living on a farm is clearly associated with S. aureus colonization, while smoking had a borderline statistically significant protective effect....

  18. Restorative procedures in disturbed function of the upper airways - nasal breathing

    OpenAIRE

    Mlynski, Gunter

    2005-01-01

    These days, functional rhinosurgery is almost always taken to mean the improvement of nasal airflow. However, air should not only pass through the nose without obstruction. It needs to be warmed, moistened and filtered. This requires sufficient air/mucous membrane contact by spreading airflow over the entire turbinate region, as well as regulation of nasal airway resistance and the degree of turbulence within the nasal cycle. These factors are not considered enough in the concept of functiona...

  19. Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)

    OpenAIRE

    Pringels, E

    2006-01-01

    As peptides are not suitable for oral administration, they are generally administered parenterally. Due to the disadvantages associated with parenteral delivery alternative routes of administration (buccal, nasal, pulmonal, ocular, transdermal, rectal and vaginal route) have been investigated. In the present work, the nasal route was selected as an alternative route for peptide delivery. Despite the advantages related to nasal administration, the bioavailability remains low. In Chapter 1 the ...

  20. Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis.

    OpenAIRE

    Braunstein, G; Malaquin, F; Fajac, I; Melac, M; Frossard, N

    1992-01-01

    This double-blind randomized crossover placebo-controlled study was designed to assess objectively the nasal antihistamine effect of cetirizine in patients with allergic rhinitis and control subjects. Nasal challenge was performed by nebulization of increasing doubling doses of histamine (0; 0.04 to 1.28 mg/nostril) in six patients with allergic rhinitis and six control subjects on cetirizine (2 x 10 mg daily for 3 days) or placebo. Sneezings were counted and nasal obstruction was assessed by...

  1. Ultrasonography in the diagnosis of nasal bone fractures: a comparison with conventional radiography and computed tomography.

    Science.gov (United States)

    Lee, In Sook; Lee, Jung-Hoon; Woo, Chang-Ki; Kim, Hak Jin; Sol, Yu Li; Song, Jong Woon; Cho, Kyu-Sup

    2016-02-01

    The purpose of this study was to evaluate and compare the diagnostic efficacy of ultrasonography (US) with radiography and multi-detector computed tomography (CT) for the detection of nasal bone fractures. Forty-one patients with a nasal bone fracture who underwent prospective US examinations were included. Plain radiographs and CT images were obtained on the day of trauma. For US examinations, radiologist used a linear array transducer (L17-5 MHz) in 24 patients and hockey-stick probe (L15-7 MHz) in 17. The bony component of the nose was divided into three parts (right and left lateral nasal walls, and midline of nasal bone). Fracture detection by three modalities was subjected to analysis. Furthermore, findings made by each modality were compared with intraoperative findings. Nasal bone fractures were located in the right lateral wall (n = 28), midline of nasal bone (n = 31), or left lateral wall (n = 31). For right and left lateral nasal walls, CT had greater sensitivity and specificity than US or radiography, and better agreed with intraoperative findings. However, for midline fractures of nasal bone, US had higher specificity, positive predictive value, and negative predictive value than CT. Although two US evaluations showed good agreements at all three sites, US findings obtained by the hockey-stick probe showed closer agreement with intraoperative findings for both lateral nasal wall and midline of nasal bone. Although CT showed higher sensitivity and specificity than US or radiography, US found to be helpful for evaluating the midline of nasal bone. Furthermore, for US examinations of the nasal bone, a smaller probe and higher frequency may be required. PMID:25749616

  2. Flow through the nasal cavity of the spiny dogfish, Squalus acanthias

    Science.gov (United States)

    Timm-Davis, L. L.; Fish, F. E.

    2015-12-01

    The nasal cavity of spiny dogfish is a blind capsule with no internal connection to the oral cavity. Water is envisioned to flow through the cavity in a smooth, continuous flow pattern; however, this assumption is based on previous descriptions of the morphology of the olfactory cavity. No experimentation on the flow through the internal nasal cavity has been reported. Morphology of the head of the spiny dogfish ( Squalus acanthias) does not suggest a close external connection between the oral and nasal systems. However, dye visualization showed that there was flow through the nasal apparatus and from the excurrent nostril to the mouth when respiratory flows were simulated. The hydrodynamic flow through the nasal cavity was observed from flow tank experiments. The dorsum of the nasal cavity of shark heads from dead animals was exposed by dissection and a glass plate was glued over of the exposed cavity. When the head was placed in a flow, dye was observed to be drawn passively into the cavity showing a complex, three-dimensional hydrodynamic flow. Dye entered the incurrent nostril, flowed through the nasal lamellae, crossed over and under the nasal valve, and circulated around the nasal valve before exiting the excurrent nostril. When the nasal valve was removed, the dye became stagnant and back flowed out through the incurrent nostril. The single nasal valve has a hydrodynamic function that organizes a coherent flow of water through the cavity without disruption. The results suggest that the morphology of the nasal apparatus in concert with respiratory flow and ambient flows from active swimming can be used to draw water through the olfactory cavity of the shark.

  3. A case-control study of mastitis: nasal carriage of Staphylococcus aureus

    OpenAIRE

    Garland Suzanne M; Amir Lisa H; Lumley Judith

    2006-01-01

    Abstract Background Mastitis is a common problem for breastfeeding women. Researchers have called for an investigation into the possible role of maternal nasal carriage of S. aureus in the causation of mastitis in breastfeeding women. Methods The aim of the study was to investigate the role of maternal S. aureus nasal carriage in mastitis. Other factors such as infant nasal S. aureus carriage, nipple damage, maternal fatigue and oversupply of milk were also investigated. A case-control design...

  4. Freeze-dried Xanthan/Guar Gum Nasal Inserts for the Delivery of Metoclopramide Hydrochloride

    OpenAIRE

    Dehghan, Mohamed Hassan; Girase, Mohan

    2012-01-01

    Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic and effective for preventing emesis induced by cancer chemotherapy, migraine, pregnancy and gastropare...

  5. Predictive Value of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Swab PCR Assay for MRSA Pneumonia

    OpenAIRE

    Dangerfield, Benjamin; Chung, Andrew; Webb, Brandon; Seville, Maria Teresa

    2014-01-01

    Pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) is associated with poor outcomes and frequently merits empirical antibiotic consideration despite its relatively low incidence. Nasal colonization with MRSA is associated with clinical MRSA infection and can be reliably detected using the nasal swab PCR assay. In this study, we evaluated the performance of the nasal swab MRSA PCR in predicting MRSA pneumonia. A retrospective cohort study was performed in a tertiary care cente...

  6. Semisupervised Community Detection by Voltage Drops

    Directory of Open Access Journals (Sweden)

    Min Ji

    2016-01-01

    Full Text Available Many applications show that semisupervised community detection is one of the important topics and has attracted considerable attention in the study of complex network. In this paper, based on notion of voltage drops and discrete potential theory, a simple and fast semisupervised community detection algorithm is proposed. The label propagation through discrete potential transmission is accomplished by using voltage drops. The complexity of the proposal is OV+E for the sparse network with V vertices and E edges. The obtained voltage value of a vertex can be reflected clearly in the relationship between the vertex and community. The experimental results on four real networks and three benchmarks indicate that the proposed algorithm is effective and flexible. Furthermore, this algorithm is easily applied to graph-based machine learning methods.

  7. Drop test of transportable storage cask

    International Nuclear Information System (INIS)

    It is being planned to transport the transportable storage casks again after their storage period of several decades, so metal gaskets are used as seal material in their lids in place of rubber o-rings which deteriorate during the storage period. Since the slightest dislocation of the lids causes seal performance deterioration in the metal gaskets, it is necessary to establish a simulation technology which accurately estimates the dislocation in order to design a rigid lid structure to protect against the impact loads under 9 m drop condition. A 1:3 scale model of the transportable storage cask developed by Hitz for BWR spent fuel rods were manufactured and 9 m drop tests were performed. Measured dislocations of the lids were confirmed within the allowable limit and they were found to be accurately simulated. (author)

  8. SURVEY OF PACKET DROPPING ATTACK IN MANET

    Directory of Open Access Journals (Sweden)

    A.Janani

    2014-03-01

    Full Text Available Mobile Ad-hoc NETwork (MANET is an application of wireless network with self-configuring mobile nodes. MANET does not require any fixed infrastructure. Its development never has any threshold range. Nodes in MANET can communicate with each other if and only if all the nodes are in the same range. This wide distribution of nodes makes MANET vulnerable to various attacks, packet dropping attack or black hole attack is one of the possible attack. It is very hard to detect and prevent. To prevent from packet dropping attack, detection of misbehavior links and selfish nodes plays a vital role in MANETs. In this paper, a omprehensive investigation on detection of misbehavior links and malicious nodes is carried out.

  9. Discrete Element Modeling of Drop Tests

    Science.gov (United States)

    Wang, Yuannian; Tonon, Fulvio

    2012-09-01

    A discrete element code with impact model has been developed and calibrated to simulate the dynamic behavior of rock materials, with special regard to rock fragmentation upon impact during rock-fall analysis. The paper summarizes the discrete element code, the calibration algorithms developed to identify the model microparameters, and the impact model. Experimental work on drop tests is then used to validate the code on modeling impact fragmentation. It has been found that the developed discrete element code and impact model can reasonably simulate rock fragmentation in drop tests. The use of the discrete element code and impact model can provide good reference results in evaluating impact fragmentation in rock-fall analysis.

  10. A pressure drop model for PWR grids

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Dong Seok; In, Wang Ki; Bang, Je Geon; Jung, Youn Ho; Chun, Tae Hyun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-12-31

    A pressure drop model for the PWR grids with and without mixing device is proposed at single phase based on the fluid mechanistic approach. Total pressure loss is expressed in additive way for form and frictional losses. The general friction factor correlations and form drag coefficients available in the open literatures are used to the model. As the results, the model shows better predictions than the existing ones for the non-mixing grids, and reasonable agreements with the available experimental data for mixing grids. Therefore it is concluded that the proposed model for pressure drop can provide sufficiently good approximation for grid optimization and design calculation in advanced grid development. 7 refs., 3 figs., 3 tabs. (Author)

  11. Control of Drop Motion by Mechanical Vibrations

    Science.gov (United States)

    Bestehorn, Michael

    2014-11-01

    Since the first experimental observations of Michael Faraday in 1831 it is known that a vibrating liquid may show an instability of its flat free surface with respect to oscillating regular surface patterns. We study thin liquid films on a horizontal substrate in the long wave approximation. The films are parametrically excited by mechanical horizontal or inclined oscillations. Inertia effects are taken into account and the standard thin film formulation is extended by a second equation for the vertically averaged mass flux. The films can be additionally unstable by Van der Waals forces on a partially wetting substrate, leading to the formation of drops. These drops can be manipulated by the vibrations to move in a desired direction. Linear results based on a damped complex valued Mathieu equation as well as fully nonlinear results using a reduced model will be presented, for more details see.

  12. In vivo deposition of ultrafine aerosols in human nasal and oral airways

    International Nuclear Information System (INIS)

    The extrathoracic airways, including the nasal passage, oral passage, pharynx, and larynx, are the first targets for inhaled particles and provide an important defense for the lung. Understanding the deposition efficiency of the nasal and oral passages is therefore crucial for assessing doses of inhaled particles to the extrathoracic airways and the lung. Significant inter-subject variability in nasal deposition has been shown in recent studies by Rasmussen, T.R. et al, using 2.6 μm particles in 10 human subjects and in our preliminary studies using 0.004-0.15 μm particles in four adult volunteers. No oral deposition was reported in either of these studies. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. The aims of the present study were to measure in vivo the nasal airway dimensions and the deposition of ultrafine aerosols in both the nasal and oral passages, and to determine the relationship between nasal airway dimensions and aerosol deposition. A statistical procedure incorporated with the diffusion theory was used to model the dimensional features of the nasal airways which may be responsible for the biological variability in particle deposition. In summary, we have correlated deposition of particles in the size range of 0.004 to 0.15 μm with the nasal dimensions of each subject

  13. Management of nasal aspergillosis in a dog with a single, noninvasive intranasal infusion of clotrimazole

    International Nuclear Information System (INIS)

    An 11-year-old, spayed female keeshond was presented for unilateral epistaxis and serous nasal discharge of four weeks duration. Initial nasal radiographs, rhinoscopy, and histopathology suggested severe, destructive lymphoplasmacytic rhinitis. The patient deteriorated while receiving an anti-inflammatory dose of prednisone. A computed tomographic scan of the nose demonstrated a soft-tissue density in both the right nasal cavity and frontal sinus. Samples for histopathology obtained at surgery were diagnostic for nasal aspergillosis. All clinical signs resolved with a single, noninvasive infusion of intranasal clotrimazole and a four-week course of oral itraconazole

  14. Differential Analysis of the Nasal Microbiome of Pig Carriers or Non-Carriers of Staphylococcus aureus

    DEFF Research Database (Denmark)

    Espinosa-Gongora, Carmen; Larsen, Niels; Schonning, Kristian;

    2016-01-01

    pathogen in animal carriers. The aim of this study was to determine whether the nasal microbiome of pig S. aureus carriers differs from that of non-carriers. The V3-V5 region of the 16S rRNA gene was sequenced from nasal swabs of 44 S. aureus carriers and 56 non-carriers using the 454 GS FLX titanium...... microbiome of pigs that are not colonized with S. aureus harbours several species/taxa that are significantly less abundant in pig carriers, suggesting that the nasal microbiota may play a role in the individual predisposition to S. aureus nasal carriage in pigs. Further research is warranted to isolate...

  15. In vivo deposition of ultrafine aerosols in human nasal and oral airways

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, Hsu-Chi; Swift, D.L. [John Hopkins Univ., Baltimore, MD (United States); Simpson, S.Q. [Univ. of New Mexico, Albuquerque, NM (United States)] [and others

    1995-12-01

    The extrathoracic airways, including the nasal passage, oral passage, pharynx, and larynx, are the first targets for inhaled particles and provide an important defense for the lung. Understanding the deposition efficiency of the nasal and oral passages is therefore crucial for assessing doses of inhaled particles to the extrathoracic airways and the lung. Significant inter-subject variability in nasal deposition has been shown in recent studies by Rasmussen, T.R. et al, using 2.6 {mu}m particles in 10 human subjects and in our preliminary studies using 0.004-0.15 {mu}m particles in four adult volunteers. No oral deposition was reported in either of these studies. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. The aims of the present study were to measure in vivo the nasal airway dimensions and the deposition of ultrafine aerosols in both the nasal and oral passages, and to determine the relationship between nasal airway dimensions and aerosol deposition. A statistical procedure incorporated with the diffusion theory was used to model the dimensional features of the nasal airways which may be responsible for the biological variability in particle deposition. In summary, we have correlated deposition of particles in the size range of 0.004 to 0.15 {mu}m with the nasal dimensions of each subject.

  16. Merocel versus Nasopore for nasal packing: a meta-analysis of randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Jianzhang Wang

    Full Text Available OBJECTIVE: To compare the clinical outcomes, including efficacy and complications, of Merocel versus Nasopore as a nasal packing material after nasal surgery. METHODS: Relevant randomized controlled trials were identified from electronic databases (The Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure and Chinese Biomedical Database. Conference proceedings and references from identified trials and review articles were also searched. Outcome measures were pain during nasal packing, pain and bleeding upon packing removal, pressure sensation, nasal blockage, formation of synechiae, mucosal healing, and patients' general satisfaction. RESULTS: Seven randomized controlled trials met criteria for analysis. Compared with Merocel, Nasopore significantly reduced patients' subjective symptoms including in situ pain (pain experienced while packing is in place, nasal pressure, pain and bleeding during packing removal, and increased patients' general satisfaction with nasal packing. There were no significant differences in nasal obstruction, adhesion and mucosal healing between the Merocel and Nasopore groups. CONCLUSIONS: Preliminary evidence suggests that Nasopore may be superior to Merocel as a nasal packing material with regard to in situ pain, pain and bleeding upon removal, pressure, and general satisfaction and does not differ from Merocel in terms of nasal obstruction, tissue adhesion, and long-term mucosal healing.

  17. Comparison of Septoplasty With and Without Nasal Packing and Review of Literature

    OpenAIRE

    Mane, Rajashri S.; Patil, Balasaheb; Mohite, Anjana

    2013-01-01

    Septoplasty is routinely performed for symptomatic deviated nasal septum. The most unpleasant part of this procedure is the pain during removal of nasal pack. The objective of this study was to compare the results of septoplasty with and without post-operative nasal packing and thereby assess the necessity of nasal packing after septoplasty. This descriptive study was carried out in ENT Department of D.Y. Patil Hospital, Kolhapur. 50 patients between the age groups of 18–50 years, having symp...

  18. Nasal base narrowing of the caucasian nose through the cerclage technique

    Directory of Open Access Journals (Sweden)

    Mocellin, Marcos

    2010-06-01

    Full Text Available Introduction: Several techniques can be performed to reduce the nasal base (narrowing, as skin resection vestibular columellar skin resection, resection of skin in elliptical lip narinary, sloughing of skin and advancements (VY technique of Bernstein and the use of cerclage sutures in the nasal base. Objective: To evaluate the technique of cerclage performed in the nasal base, through endonasal rhinoplasty without delivery of basic technique, in the Caucasian nose, reducing the distance inter-alar flare and correcting the wing with consequent improvement in nasal harmony in the whole face. Methods: A retrospective analysis by analysis of clinical documents and photos of 43 patients in whom cerclage was made of the nasal base by resecting skin ellipse in the region of the vestibule and the nasal base (modified technique of Weir using colorless mononylon® 4 "0" with a straight cutting needle. The study was conducted in 2008 and 2009 at Hospital of Paraná Institute of Otolaryngology - IPO in Curitiba, Parana - Brazil. Patients had a follow up ranging 7-12 months. Results: In 100% of cases was achieved an improvement in nasal harmony, by decreasing the inter-alar distance. Conclusion: The encircling with minimal resection of vestibular skin and the nasal base is an effective method for the narrowing of the nasal base in the Caucasian nose, with predictable results and easy to perform.

  19. Nasal septal abscess--retrospective analysis of 14 cases from University Hospital, Kuala Lumpur.

    Science.gov (United States)

    Jalaludin, M A

    1993-10-01

    Fourteen patients who presented to the University Hospital of Kuala Lumpur between June 1981 and June 1991 were reviewed retrospectively. Nasal septal abscesses are uncommon and therefore there are limited reports in the medical literature. Early diagnosis and immediate therapy is mandatory to avoid cosmetic nasal deformity or intracranial infection. Two out of the fourteen patients developed saddle nose deformity and septal perforation because of delay in treatment, the cases were misdiagnosed by non-otolaryngologist as turbinates swelling. The leading cause of nasal septal abscess was non-surgical trauma which accounted for about 85.7%. The commonest pathogenic organism isolated from the pus of nasal septal abscess was Staphylococcus aureus.

  20. Clara cell protein in nasal lavage fluid and nasal nitric oxide - biomarkers with anti-inflammatory properties in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Irander Kristina

    2012-02-01

    Full Text Available Abstract Background Clara cell protein (CC16 is ascribed a protective and anti-inflammatory role in airway inflammation. Lower levels have been observed in asthmatic subjects as well as in subjects with intermittent allergic rhinitis than in healthy controls. Nasal nitric oxide (nNO is present in high concentrations in the upper airways, and considered a biomarker with beneficial effects, due to inhibition of bacteria and viruses along with stimulation of ciliary motility. The aim of this study was to evaluate the presumed anti-inflammatory effects of nasal CC16 and nNO in subjects with allergic rhinitis. Methods The levels of CC16 in nasal lavage fluids, achieved from subjects with persistent allergic rhinitis (n = 13, intermittent allergic rhinitis in an allergen free interval (n = 5 and healthy controls (n = 7, were analyzed by Western blot. The levels of nNO were measured by the subtraction method using NIOX®. The occurrences of effector cells in allergic inflammation, i.e. metachromatic cells (MC, mast cells and basophiles and eosinophils (Eos were analyzed by light microscopy in samples achieved by nasal brushing. Results The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02 in allergic subjects. The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03 and nNO (p = 0.05 were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC. Similar relationships, but not reaching significance, were observed between the CC16 and nNO levels and Eos occurrence. The levels of CC16 and nNO did not differ between the allergic and the control groups. Conclusions The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of

  1. Modeling Evaporation of Drops of Different Kerosenes

    Science.gov (United States)

    Bellan, Josette; Harstad, Kenneth

    2007-01-01

    A mathematical model describes the evaporation of drops of a hydrocarbon liquid composed of as many as hundreds of chemical species. The model is intended especially for application to any of several types of kerosenes commonly used as fuels. The concept of continuous thermodynamics, according to which the chemical composition of the evaporating multicomponent liquid is described by use of a probability distribution function (PDF). However, the present model is more generally applicable than is its immediate predecessor.

  2. Impact of water drops on small targets

    Science.gov (United States)

    Rozhkov, A.; Prunet-Foch, B.; Vignes-Adler, M.

    2002-10-01

    The collision of water drops against small targets was studied experimentally by means of a high-speed photography technique. The drop impact velocity was about 3.5 m/s. Drop diameters were in the range of 2.8-4.0 mm. The target was a stainless steel disk of 3.9 mm diameter. The drop spread beyond the target like a central cap surrounded by a thin, slightly conical lamella bounded by a thicker rim. By mounting a small obstacle near the target, surface-tension driven Mach waves in the flowing lamella were generated, which are formally equivalent to the familiar compressibility driven Mach waves in gas dynamics. From the measurement of the Mach angle, the values of some flow parameters could be obtained as functions of time, which provided insight into the flow structure. The liquid flowed from the central cap to the liquid rim through the thin lamella at constant momentum flux. At a certain stage of the process, most of the liquid accumulated in the rim and the internal part of the lamella became metastable. In this situation, a rupture wave propagating through the metastable internal part of the lamella caused the rim to retract while forming outwardly directed secondary jets. The jets disintegrated into secondary droplets due to the Savart-Plateau-Rayleigh instability. Prior to the end of the retraction, an internal circular wave of rupture was formed. It originated at the target and then it propagated to meet the retracting rim. Their meeting resulted in a crown of tiny droplets. A theoretical analysis of the ejection process is proposed.

  3. Tendon transfers for the drop foot.

    Science.gov (United States)

    Schweitzer, Karl M; Jones, Carroll P

    2014-03-01

    The paralytic drop foot represents a challenging problem for even the most experienced orthopedic surgeon. Careful patient selection, thorough preoperative examination and planning, and application of tendon transfer biomechanical and physiologic principles outlined in this article can lead to successful results, either through a posterior tibialis tendon transfer, Bridle transfer, or variations on these procedures. Achilles lengthening or gastrocnemius recession may also be needed at the time of tendon transfer. PMID:24548510

  4. Low-Pressure-Drop Shutoff Valve

    Science.gov (United States)

    Thornborrow, John

    1994-01-01

    Flapper valve remains open under normal flow conditions but closes upon sudden increases to high rate of flow and remains closed until reset. Valve is fluid/mechanical analog of electrical fuse or circuit breaker. Low-pressure-drop shutoff valve contains flapper machined from cylindrical surface. During normal flow conditions, flapper presents small cross section to flow. (Useful in stopping loss of fluid through leaks in cooling systems.)

  5. Drop floating on a granular raft

    Science.gov (United States)

    Jambon-Puillet, Etienne; Josserand, Christophe; Protiere, Suzie

    2015-11-01

    When a droplet comes in contact with a bath of the same liquid, it coalesces to minimize the surface energy. This phenomenon reduces emulsion stability and is usually fought with surfactant molecules. Another way to slow down coalescence is to use colloidal solid particles. In this case the particles spontaneously migrate to the interface to form ``Pickering'' emulsions and act as a barrier between droplets. Here we use dense, large particles (~ 500 μm) which form a monolayer at an oil/water interface that we call a granular raft. When a droplet is placed on top of such a raft, for a given set of particle properties (contact angle/size), the raft prevents coalescence indefinitely. However, in contrast to what happens when a droplet is placed on a hydrophobic surface and never wets the surface, here the droplet is strongly anchored to the raft and deforms it. We will use this specific configuration to probe the mechanical response of the granular raft: by controlling the droplet volume we can impose tensile or compressive stresses. Finally we will show that the drop, spherical at first, slowly takes a more complex shape as it's volume increases. This shape is not reversible as the drop volume is decreased. The drop can become oblate or prolate with wrinkling of the raft.

  6. Ultrafast Drop Movements Arising from Curvature Gradient

    CERN Document Server

    Lv, Cunjing; Chuang, Yin-Chuan; Tseng, Fan-Gang; Yin, Yajun; Zheng, Quanshui

    2011-01-01

    We report experimental observation of a kind of fast spontaneous movements of water drops on surfaces of cones with diameters from 0.1 to 1.5 mm. The observed maximum speed (0.22 m/s) under ambient conditions were at least two orders of magnitude higher than that resulting from any known single spontaneous movement mechanism, for example, Marangoni effect due to gradient of surface tension. We trapped even higher spontaneous movement speeds (up to 125 m/s) in virtual experiments for drops on nanoscale cones by using molecular dynamics simulations. The underlying mechanism is found to be universally effective - drops on any surface either hydrophilic or hydrophobic with varying mean curvature are subject to driving forces toward the gradient direction of the mean curvature. The larger the mean curvature of the surface and the lower the contact angle of the liquid are, the stronger the driving force will be. This discovery can lead to more effective techniques for transporting droplets.

  7. Drop impacts on electrospun nanofiber membranes

    Science.gov (United States)

    Sahu, Rakesh P.; Sinha-Ray, Suman; Yarin, Alexander; Pourdeyhimi, Behnam

    2013-11-01

    This work reports a study of drop impacts of polar and non-polar liquids onto electrospun nanofiber membranes (of 8-10 mm thickness and pore sizes of 3-6 nm) with an increasing degree of hydrophobicity. The nanofibers used were electrospun from polyacrylonitrile (PAN), nylon 6/6, polycaprolactone (PCL) and Teflon. It was found that for any liquid/fiber pair there exists a threshold impact velocity (1.5 to 3 m/s) above which water penetrates membranes irrespective of their wettability. The low surface tension liquid left the rear side of sufficiently thin membranes as a millipede-like system of tiny jets protruding through a number of pores. For such a high surface tension liquid as water, jets immediately merged into a single bigger jet, which formed secondary drops due to capillary instability. An especially non-trivial result is that superhydrophobicity of the porous nano-textured Teflon skeleton with the interconnected pores is incapable of preventing water penetration due to drop impact, even at relatively low impact velocities close to 3.46 m/s. A theoretical estimate of the critical membrane thickness sufficient for complete viscous dissipation of the kinetic energy of penetrating liquid corroborates with the experimental data. The current work is supported by the Nonwovens Cooperative Research Center (NCRC).

  8. Cusp formation in drops inside Taylor cones

    Science.gov (United States)

    Marin, Alvaro G.; Loscertales, Ignacio G.; Barrero, Antonio

    2005-11-01

    Here, we report the formation of cusp in insulating drops inside compound Taylor cones. The action of the electrical shear stress acting on the outer interface, which is transmitted by viscous forces inside the Taylor cone, tends to deform the drop of insulating liquid placed inside. For appropriate values of the capillary number, the insulating drop develops a steady cusp angle which depends on both the capillary number and the conducting to insulating viscosity ratio. A self-similar analysis has been developed to qualitatively describe the flow inside these compounds Taylor cones. Any perturbation of the cusp gives rise to an intermittent emission of tiny droplets; this effect may recall the tip-streaming observed by G.I. Taylor in his four-roll mill device. This emission can be stabilized by an appropriate control of the injected flow rate of the insulating liquid. When the capillary number increases, the cusped interface turns into a spout which flows coated by the conducting liquid forming the electrified coaxial jet which has been successfully employed for the production of nanocapsules, coaxial nanofibers and nanotubes (Science 295, n. 5560, 1695, 2002; JACS 126, 5376, 2004).

  9. Dielectrophoresis of a surfactant-laden viscous drop

    Science.gov (United States)

    Mandal, Shubhadeep; Bandopadhyay, Aditya; Chakraborty, Suman

    2016-06-01

    The dielectrophoresis of a surfactant-laden viscous drop in the presence of non-uniform DC electric field is investigated analytically and numerically. Considering the presence of bulk-insoluble surfactants at the drop interface, we first perform asymptotic solution for both low and high surface Péclet numbers, where the surface Péclet number signifies the strength of surface convection of surfactants as compared to the diffusion at the drop interface. Neglecting fluid inertia and interfacial charge convection effects, we obtain explicit expression for dielectrophoretic drop velocity for low and high Péclet numbers by assuming small deviation of drop shape from sphericity and small deviation of surfactant concentration from the equilibrium uniform distribution. We then depict a numerical solution, assuming spherical drop, for arbitrary values of Péclet number. Our analyses demonstrate that the asymptotic solution shows excellent agreement with the numerical solution in the limiting conditions of low and high Péclet numbers. The present analysis shows that the flow-induced redistribution of the surfactants at the drop interface generates Marangoni stress, owing to the influence of the surfactant distribution on the local interfacial tension, at the drop interface and significantly alters the drop velocity at steady state. For a perfectly conducting/dielectric drop suspended in perfectly dielectric medium, Marangoni stress always retards the dielectrophoretic velocity of the drop as compared with a surfactant-free drop. For a leaky dielectric drop suspended in another leaky dielectric medium, in the low Péclet number limit, depending on the electrical conductivity and permittivity of both the liquids, the Marangoni stress may aid or retard the dielectrophoretic velocity of the drop. The Marangoni stress also has the ability to move the drop in the opposite direction as compared with a surfactant-free drop. This non-intuitive reverse motion of the drop is

  10. Local IgE production in nonatopic nasal polyposis.

    LENUS (Irish Health Repository)

    Sheahan, Patrick

    2012-02-01

    INTRODUCTION: Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents an eosinophilic T-helper 2 inflammatory response. Local production of IgE within nasal polyps (NPs) has been demonstrated, suggesting a role for local IgE in the pathogenesis of NP in atopic CRS patients. We hypothesized that local IgE specific to inhalant allergens may also play a role in the genesis of NP in nonatopic CRS patients. METHODS: Sinus and inferior turbinate tissue was obtained from nonatopic CRSwNP patients (n = 7), chronic rhinosinusitis without nasal polyps (CRSsNP) patients (n = 15), and healthy controls (n = 9) at the time of surgery. ImmunoCAP analysis (Phadia AB, Portage, MI) for 14 common inhalant antigens was performed on tissue homogenates to determine the antigen-specific response. RESULTS: Total IgE levels did not differ in sinus or turbinate tissue between CRSwNP, CRSsNP, or control patients. CRSwNP sinus tissue had higher levels of specific IgE for cockroach and plantain (p = .03) than other groups and elevated Alternaria IgE levels when compared with CRSsNP sinus tissue (p < .05). No significant differences were found for any of the other antigen-specific IgE levels. Fifty-seven percent of CRSwNP polyps demonstrated a polyclonal IgE response, whereas the other 43% had no demonstrable antigen-specific IgE. In contrast, only 17% of CRSsNP patients demonstrated a polyclonal response within sinus tissue, whereas 67% had no detectable antigen-specific IgE. There was no significant difference in levels of IgE in inferior turbinate tissue between the groups (p > .05). CONCLUSIONS: Localized mucosal IgE specific to common inhalant allergens appears to play a role in a subset of CRSwNP patients without evidence of systemic atopy.

  11. Treatment outcome of nasal natural killer/T-cell lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyubn Jin; Lee, Sang Wook; Suh, Cheol Won; Huh, Joo Ryung; Yoon, Sang Min; Kim, Young Seok; Kim, Su San; Kim, Jong Hoon; Choi, Eun Kyung; Ahn, Seung Do [Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2011-09-15

    To evaluate the radiotherapy treatment outcome of patients in stage IE and IIE nasal natural killer/T-cell lymphoma. From August 1999 to August 2009, 46 patients with stage IE and IIE nasal natural killer/T-cell lymphoma were treated by definitive radiotherapy and chemotherapy. 33 patients were treated with chemotherapy followed by radiotherapy (CT + RT) and they received 50.4 Gy in 28 fractions. 13 patients were treated with concurrent chemoradiotherapy (CCRT) and they received 40 Gy in 20 fractions. The median follow-up period was 4.6-137.6 months (median, 50.2 months) for all patients. The 4-year overall survival was 68.6% and 4-year disease free survival (DFS) was 61.9%. The 4-year locoregional recurrence free survival was 65.0%, and 4-year distant metastasis free survival (DMFS) was 66.2%. For patients treated with CT + RT, 15 patients (45.5%) achieved complete response after chemotherapy, and 13 patients (39.4%) achieved partial response. 13 patients (81.8%) achieved complete response after radiotherapy, and 6 patients (18.2%) achieved partial response. For patients treated with CCRT, 11 patients (84.6%) achieved complete response, and one patient (7.7%) achieved partial response. In univariate analysis, presence of cervical lymph node metastasis was only significant prognostic factor for DFS and DMFS. This study did not show satisfactory overall survival rate and disease free survival rate of definitive radiotherapy and chemotherapy for stage IE and IIE nasal natural killer/T-cell lymphoma. For patients with cervical lymph node metastasis, further investigation of new chemotherapy regimens is necessary to reduce the distant metastasis.

  12. Feasibility of coblation versus laser resection in recurrent nasal polyps

    Science.gov (United States)

    Ilgner, Justus; Schramm, Karsten; Duwel, Philip; Donner, Andreas; Westhofen, Martin

    2005-04-01

    Introduction: Chronic sinusitis with nasal polyps is one of the commonest diseases of the upper airways, with a recurrence rate of about 15%. Minimally-invasive endoscopic laser procedures have been established to reduce the need for conventional revision surgery whenever medical follow-up fails. However, laser surgery requires special considerations for surgical, safety and economic aspects. This study evaluates the feasibility of coblation versus laser resection for recurrent nasal polyps. Material and methods: 6 nasal polyps were harvested each from the ostiomeatal complex of patients undergoing microscopic endonasal surgery for chronic sinusitis. 3 were dissected using a Neodymium:YAG laser system (Dornier MediLas 5060N) set at 10, 20 and 30w in cw mode with a 600μm bare fiber in contact mode with negative feedback power control, while further 3 polyps were dissected using a Coblation system (ArthroCare® Coblator® I) with a 30° angled and a 0° straight probe with 2.4 mm outer diameter. The specimens were examined histologically for carbonization and coagulation as well as unaltered tissue. Results: Laser resection resulted in a carbonization zone of 30μm in depth plus a coagulation zone of about 100μm, depending on the water content and type of tissue. While the carbonization zone was smaller with coblation, coagulation zones were comparable, leaving ample amount of unaltered tissue available for further diagnosis. Conclusion: Both resection techniques are generally feasible to be used in day case surgery for recurrent polyps. While the coblation system required no special safety requirements, accessibility of the sinuses was limited by the rigidity of applicators that are available.

  13. Immunological role of nasal staphylococcus aureus carriage in patients with persistent allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Mohamed Yousif Atia

    2008-10-01

    Full Text Available Nasal carriage of staphylococcus aureus (S.aureus exerts immunomodulatory effect in patients with atopic dermatitis and it may contribute to airway inflammation and allergic response in patients with allergic rhinitis. We Aim to investigate the frequency of nasal S.aureus carriage in patients with persistent allergic rhinitis and its possible influence on their symptoms and immune markers. We chosed 20 non smoker patients with house dust mite (HDM allergy causing allergic rhinitis and 20 non smoker healthy subjects matched for age and sex. For all subjects rhinoscopy was done, skin prick test, nasal culture for S.aureus, nasal interleukin 4,nasal total IgE, serum total IgE and serum specific IgE(SSIgE for HDM. Nasal S.aureus was detected in 16/20 patients (80% and 5/20 (25% in healthy subjects with highly significant statistical difference plt0.01. Correlation of nasal staph.aureus count and different systemic and local immune markers revealed highly significant positive correlation between nasal S.aureus count and serum total IgE (r = 0.78, plt0.01 and significant positive correlation with SSIgE (HDM (r = 0.53, plt0.05, nasal total IgE (r = 0.39, plt0.05 and nasal IL-4 (r = 0.55, plt0.05. Nasal staph.aureus actively modulated the immune reaction in persistent allergic rhinitis patients by promoting local IgE production, so we recommend early detection and treatment of S.aureus carriage in patients

  14. Predictors of Nasal Obstruction: Quantification and Assessment Using Multiple Grading Scales

    Science.gov (United States)

    Camacho, Macario; Zaghi, Soroush; Certal, Victor; Abdullatif, Jose; Modi, Rahul; Sridhara, Shankar; Tolisano, Anthony M.; Chang, Edward T.; Cable, Benjamin B.; Capasso, Robson

    2016-01-01

    Objective. To evaluate the association between nasal obstruction and (1) demographic factors, (2) medical history, (3) physical tests, and (4) nasal exam findings. Study Design. Case series. Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1 ± 17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE) score of 32.0 ± 24.1) were included. Demographic factors and inferior turbinate sizes were not associated with NOSE score or Nasal Obstruction Visual Analog Scale (NO-VAS). A significant association was found between higher NOSE score on univariate analysis and positive history of nasal trauma (p = 0.0136), allergic rhinitis (p < 0.0001), use of nasal steroids (p = 0.0108), higher grade of external nasal deformity (p = 0.0149), higher internal nasal septal deviation grade (p = 0.0024), and narrow internal nasal valve angle (p < 0.0001). Multivariate analysis identified the following as independent predictors of high NOSE score: NO-VAS: ≥50 (Odds Ratio (OR) = 17.6 (95% CI 5.83–61.6), p < 0.0001), external nasal deformity: grades 2–4 (OR = 4.63 (95% CI 1.14–19.9), p = 0.0339), and allergic rhinitis: yes (OR = 5.5 (95% CI 1.77–18.7), p = 0.0041). Conclusion. Allergic rhinitis, NO-VAS score ≥ 50, and external nasal deformity (grades 2–4) were statistically significant independent predictors of high NOSE scores on multivariate analysis. Inferior turbinate size was not associated with NOSE scores or NO-VAS. PMID:27293885

  15. Predictors of Nasal Obstruction: Quantification and Assessment Using Multiple Grading Scales

    Directory of Open Access Journals (Sweden)

    Macario Camacho

    2016-01-01

    Full Text Available Objective. To evaluate the association between nasal obstruction and (1 demographic factors, (2 medical history, (3 physical tests, and (4 nasal exam findings. Study Design. Case series. Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1±17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE score of 32.0±24.1 were included. Demographic factors and inferior turbinate sizes were not associated with NOSE score or Nasal Obstruction Visual Analog Scale (NO-VAS. A significant association was found between higher NOSE score on univariate analysis and positive history of nasal trauma (p=0.0136, allergic rhinitis (p<0.0001, use of nasal steroids (p=0.0108, higher grade of external nasal deformity (p=0.0149, higher internal nasal septal deviation grade (p=0.0024, and narrow internal nasal valve angle (p<0.0001. Multivariate analysis identified the following as independent predictors of high NOSE score: NO-VAS: ≥50 (Odds Ratio (OR = 17.6 (95% CI 5.83–61.6, p<0.0001, external nasal deformity: grades 2–4 (OR = 4.63 (95% CI 1.14–19.9, p=0.0339, and allergic rhinitis: yes (OR = 5.5 (95% CI 1.77–18.7, p=0.0041. Conclusion. Allergic rhinitis, NO-VAS score ≥ 50, and external nasal deformity (grades 2–4 were statistically significant independent predictors of high NOSE scores on multivariate analysis. Inferior turbinate size was not associated with NOSE scores or NO-VAS.

  16. Stable Dry Powder Formulation for Nasal Delivery of Anthrax Vaccine

    OpenAIRE

    Wang, Sheena H.; Kirwan, Shaun M.; Abraham, Soman N.; Staats, Herman F.; Hickey, Anthony J.

    2011-01-01

    There is a current biodefense interest in protection against Anthrax. Here we developed a new generation of stable and effective anthrax vaccine. We studied the immune response elicited by rPA delivered intranasally with a novel mucosal adjuvant, a mast cell activator Compound 48/80. The vaccine formulation was prepared in a powder form by spray-freeze-drying (SFD) under optimized conditions to produce particles with a target size of D50=25μm, suitable for delivery to the rabbit nasal cavity....

  17. Aplicaciones del colgajo frontonasal para la cobertura de defectos nasales

    Directory of Open Access Journals (Sweden)

    M. Pérez

    2015-12-01

    Full Text Available Presentamos una revisión retrospectiva de los pacientes a los cuales se realizó un colgajo frontonasal para la cobertura de defectos nasales intervenidos en la Unidad de Tumores Cutáneos de nuestro Servicio en el periodo comprendido entre enero de 2010 y mayo de 2014. El objetivo es analizar nuestras aplicaciones y resultados además de describir un algoritmo que permita indicar los distintos diseños en función de la localización y el tamaño del defecto a reparar. Empleamos el colgajo frontonasal en 78 pacientes (49 mujeres y 29 varones con un rango de edad de 47 a 92 años (media de 73 años. Creamos un total de 81 defectos, puesto que en 3 casos se resecaron simultáneamente 2 tumoraciones, todos de etiología tumoral (64 carcinomas basocelulares, 16 carcinomas espinocelulares y 1 caso de léntigo maligno melanoma, localizados en el área nasal, con un tamaño mínimo de 12 x 17 mm y máximo de 30 x 35 mm (media de 22 x 25 mm. El periodo de seguimiento fue de entre 2 meses y 4 años (media de 2,5 años. Respecto a las complicaciones observadas, todas ellas menores, hubo 6 casos de necrosis marginal, 8 de dehiscencia parcial de la herida y 1 de cicatrización hipertrófica, tratándose en su mayor parte de varones fumadores. Todos los colgajos sobrevivieron con resultado estético satisfactorio. El colgajo frontonasal permite la cobertura en un sólo tiempo quirúrgico de defectos nasales independientemente de su localización, de hasta 30 x 35 mm en nuestra serie. Se trata de un colgajo seguro y versátil en sus múltiples modificaciones, con unos resultados estéticos satisfactorios. Estas ventajas son de especial importancia en pacientes de edad avanzada como alternativa a técnicas más complejas. Se trata por lo tanto, a nuestro juicio, de una opción a tener en cuenta para la reconstrucción en un único tiempo quirúrgico de defectos nasales.

  18. Nasal airway nitric oxide : Methodological aspects and influence of inflammation

    OpenAIRE

    Palm, Jörgen

    2004-01-01

    Nitric oxide (NO) is an endogenously formed free radical gas involved in numerous biological processes. In 1991 NO was discovered to be present in exhaled air of humans. Soon after, it was reported that the largest amounts of NO were found in the upper airways, and that the levels of NO were increased in the lower airways of patients with asthma. The high levels of NO in the nasal region are believed to be involved in functions as various as primary host defence, including k...

  19. Nasal highflow improves ventilation in patients with COPD

    Directory of Open Access Journals (Sweden)

    Bräunlich J

    2016-05-01

    Full Text Available Jens Bräunlich,* Marcus Köhler,* Hubert WirtzDepartment of Respiratory Medicine, University of Leipzig, Leipzig, Germany *These authors contributed equally to this workBackground: Nasal highflow (NHF provides a warmed and humidified air stream up to 60 L/min. Recent data demonstrated a positive effect in patients with acute hypoxemic respiratory failure, especially when caused by pneumonia. Preliminary data show a decrease in hypercapnia in patients with COPD. Therefore, NHF should be evaluated as a new ventilatory support device. This study was conducted to assess the impact of different flow rates on ventilatory parameters in patients with COPD.Materials and methods: This interventional clinical study was performed with patients suffering from severe COPD. The aim was to characterize flow-dependent changes in mean airway pressure, breathing volumes, breathing frequency, and decrease in partial pressure of CO2 (pCO2. Mean airway pressure was measured in the nasopharyngeal space (19 patients. To evaluate breathing volumes, we used a polysomnographic device (18 patients. All patients received 20 L/min, 30 L/min, 40 L/min, and 50 L/min and – to illustrate the effects – nasal continuous positive airway pressure and nasal bilevel positive airway pressure. Capillary blood gas analyses were performed in 54 patients with hypercapnic COPD before and two hours after the use of NHF. We compared the extent of decrease in pCO2 when using 20 L/min and 30 L/min. Additionally, comfort and dyspnea during the use of NHF were surveyed.Results: NHF resulted in a minor flow dependent increase in mean airway pressure. Tidal volume increased, and breathing rate decreased. The calculated minute volume decreased under NHF breathing. In spite of this fact, hypercapnia decreased with increasing flow (20 L/min vs 30 L/min. Additionally, an improvement in dyspnea was observed. The rapid shallow breathing index shows a decrease when using NHF.Conclusion: NHF

  20. Decreased Expression of FOXP3 in Nasal Polyposis

    OpenAIRE

    Roongrotwattanasiri, Kannika; Pawankar, Ruby; KIMURA, SATOKO; Mori, Sachiko; Nonaka, Manabu; Yagi, Toshiaki

    2011-01-01

    Purpose The pathogenesis of nasal polyposis (NP) is unclear. Eosinophils and mast cells are considered to play important roles in this process. In addition, the levels of Th2-type cells are increased, irrespective of the atopic status of the patient with NP. In this context, we and others have shown high levels of thymus and activation-related chemokine/CCL17, macrophage-derived chemokine, eotaxin, and RANTES in patients with NP. Forkhead box P3 (FOXP3) plays a key role in CD4+CD25+ regulator...

  1. Nasal Potential Difference in Cystic Fibrosis considering Severe CFTR Mutations

    OpenAIRE

    2015-01-01

    The gold standard for diagnosing cystic fibrosis (CF) is a sweat chloride value above 60 mEq/L. However, this historical and important tool has limitations; other techniques should be studied, including the nasal potential difference (NPD) test. CFTR gene sequencing can identify CFTR mutations, but this method is time-consuming and too expensive to be used in all CF centers. The present study compared CF patients with two classes I-III CFTR mutations (10 patients) (G1), CF patients with class...

  2. [Non-puncture treatment of sinusitis in nasal septal defects].

    Science.gov (United States)

    Shilenkova, V V; Markov, G I; Shilenkov, A A

    1994-01-01

    The [symbol: see text] sinus-catheter was used to treat purulent sinusitis with septal perforation or defective septum of the sinuses. The procedure described implies simultaneous introduction of two sinus-catheters the functioning channels of which unite into one output by means of T-joint. The method has been successfully tried in the treatment of exudative and aggravated chronic purulent hemisinusitis (6 cases). The authors hold that communication between nasal sinuses is not a contraindication for sinus-catheter application. This fact widely extends potentialities of its use.

  3. Oscillating and star-shaped drops levitated by an airflow

    CERN Document Server

    Bouwhuis, Wilco; Peters, Ivo R; Brunet, Philippe; van der Meer, Devaraj; Snoeijer, Jacco H

    2013-01-01

    We investigate the spontaneous oscillations of drops levitated above an air cushion, eventually inducing a breaking of axisymmetry and the appearance of `star drops'. This is strongly reminiscent of the Leidenfrost stars that are observed for drops floating above a hot substrate. The key advantage of this work is that we inject the airflow at a constant rate below the drop, thus eliminating thermal effects and allowing for a better control of the flow rate. We perform experiments with drops of different viscosities and observe stable states, oscillations and chimney instabilities. We find that for a given drop size the instability appears above a critical flow rate, where the latter is largest for small drops. All these observations are reproduced by numerical simulations, where we treat the drop using potential flow and the gas as a viscous lubrication layer. Qualitatively, the onset of instability agrees with the experimental results, although the typical flow rates are too large by a factor 10. Our results...

  4. Rolling ferrofluid drop on the surface of a liquid

    CERN Document Server

    Sterr, V; Morozov, K I; Rehberg, I; Engel, A; Richter, R

    2008-01-01

    We report on the controlled transport of drops of magnetic liquid, which are swimming on top of a non-magnetic liquid layer. A magnetic field which is rotating in a vertical plane creates a torque on the drop. Due to surface stresses within the immiscible liquid beneath, the drop is propelled forward. We measure the drop speed for different field amplitudes, field frequencies and drop volumes. Simplifying theoretical models describe the drop either as a solid sphere with a Navier slip boundary condition, or as a liquid half-sphere. An analytical expression for the drop speed is obtained which is free of any fitting parameters and is well in accordance with the experimental measurements. Possible microfluidic applications of the rolling drop are also discussed.

  5. Drop-by-drop chemical reaction and sample introduction for capillary electrophoresis.

    Science.gov (United States)

    Chen, Fengming; Rang, Ying; Weng, Ying; Lin, Luyao; Zeng, Hulie; Nakajim, Hizuru; Lin, Jin-Ming; Uchiyama, Katsumi

    2015-06-21

    In this paper, we report a novel sample introduction and chemical reaction strategy by drop-by-drop inkjet injection for an electrophoretically mediated microanalysis (EMMA). This method makes it possible to achieve an on-line introduction of reactant solutions by alternately ejecting small plugs, with an overlapping region of the plugs for mixing the reactants by electrophoresis, supporting chemical reactions, followed by electrophoretic separation of the final compounds. As a proof-of-concept of the method, the EMMA of an inkjetted mixture of 4-fluoro-7-nitrobenzofurazan (NBD-F) and amino acids was carried out as a model chemical reaction. The product NBD-amino acids were quantified by detection with laser induced fluorescence. The optimal conditions for the procedure were: inkjet driving voltage: +40-44 V; pulse width: 20-24 μs; drop-by-drop injection of reactant solutions: alternately 2 drops × 25 times for the amino acid solution and the NBD-F solution; zone overlapping voltage and time: 3 kV and 2 s; incubation time after overlapping: 5 min; separation voltage: 18 kV. Under the optimized conditions, a significant enhancement in sensitivity and a sensitive quantitative analysis were realized. The results obtained were comparable with those using the off-line labeling method. This method is rapid, cost-effective, and readily automated for EMMA. PMID:25728632

  6. Tolerability and effects on quality of life of liposomal nasal spray treatment compared to nasal ointment containing dexpanthenol or isotonic NaCl spray in patients with rhinitis sicca

    OpenAIRE

    Hahn, C; Böhm, M.; Allekotte, S.; Mösges, R

    2013-01-01

    This study aimed to investigate symptom reduction via the liposomal nasal spray LipoNasal (LN) in patients with rhinitis sicca. Tolerability and the impact on quality of life were also examined. The same parameters were established in parallel for treatment approaches with Bepanthen (BP) nasal ointment containing dexpanthenol and the Rhinomer (RH) nasal spray containing NaCl. This prospective, controlled, open-label observation study was a multicenter trial. 92 patients with rhinitis sicca we...

  7. Bioactivities of some essential oils against the camel nasal botfly, Cephalopina titillator.

    Science.gov (United States)

    Khater, Hanem F

    2014-02-01

    Nasopharyngeal myiasis of camels is caused by the larvae of Cephalopina titillator. We determined the efficacy of essential oils (EOs) of pumpkin, Cucurbita maxima; lupinus, Lupinus luteus; garlic oil, Allium sativum; and peppermint, Mentha piperita, against the third larval stage of C. titillator using larval immersion tests. The positive control group was treated with ivermectin and the negative control one was treated with distilled water and few drops of Tween 80. Larvae were reared until adult emergence. The data indicated that complete larval mortalities were reached 24 h post treatment (PT) with 2 % pumpkin, 7.5 % garlic and peppermint, 30 % lupinus, and 0.15 % ivermectin. The lethal values, LC50s, were 0.20, 0.44, 0.42, 0.47, and 0.03 %, respectively. Pumpkin and ivermectin were 2 and 17 times, respectively, more effective than the other EOs. Ivermectin was seven times more intoxicating than pumpkin oil. Formation of pupae had been stopped after treatment of larvae with 2 % pumpkin, 7.5 % garlic and peppermint, 30 % lupines, and 0.04 % ivermectin. Adult emergence had been completely ceased following treatment of larvae with 0.5 % EOs and 0.04 % ivermectin. Morphological abnormalities were pronounced after treatments, and peppermint oil was the foremost cause of deformation in larvae (44 % PT with 7.5 %) and pupae (40 % PT with 2 %). Pumpkin oil (6 %) was selected to be the drug of choice for controlling C. titillator. Besides their insecticidal effects, EOs are much safer than ivermectin regarding health and environmental issues. Consequently, EOs described herein merit further study as potential nasal drench for C. titillator control. PMID:24276644

  8. The influence of surface tension gradients on drop coalescence

    OpenAIRE

    Blanchette, François; Messio, Laura; Bush, John W.M.

    2009-01-01

    We present the results of a combined experimental and numerical investigation of the coalescence of a drop with a liquid reservoir of a miscible but distinct fluid. Particular attention is given to elucidating the influence on the coalescence process of a surface tension difference between drop and reservoir. Drops are gently deposited on the surface of the reservoir, and so coalesce with negligible initial vertical velocity. Depending on the drop size and reservoir composition, partial or to...

  9. Dynamics of Ferrofluidic Drops Impacting Superhydrophobic Surfaces

    CERN Document Server

    Bolleddula, D A; Alliseda, A; Bhosale, P; Berg, J C

    2010-01-01

    This is a fluid dynamics video illustrating the impact of ferrofluidic droplets on surfaces of variable wettability. Surfaces studied include mica, teflon, and superhydrophobic. A magnet is placed beneath each surface, which modifies the behavior of the ferrofluid by applying additional downward force apart from gravity resulting in reduced droplet size and increased droplet velocity. For the superhydrophobic droplet a jetting phenomena is shown which only occurs in a limited range of impact speeds, higher than observed before, followed by amplified oscillation due to magnetic field as the drop stabilizes on the surface.

  10. Solid drop based liquid-phase microextraction.

    Science.gov (United States)

    Ganjali, Mohammad Reza; Sobhi, Hamid Reza; Farahani, Hadi; Norouzi, Parviz; Dinarvand, Rassoul; Kashtiaray, Amir

    2010-04-16

    Solid drop based liquid-phase microextraction (SDLPME) is a novel sample preparation technique possessing obvious advantages of simple operation with a high pre-concentration factor, low cost and low consumption of organic solvent. SDLPME coupled with gas chromatography (GC), high-performance liquid chromatography (HPLC), and atomic absorption spectrometry (AAS) has been widely applied to the analyses of a different variety of samples. The basic principles, parameters affecting the extraction efficiency, and the latest applications of SDLPME are reviewed in this article. PMID:19962710

  11. DNA Dynamics in A Water Drop

    CERN Document Server

    Mazur, A K

    2002-01-01

    Due to its polyionic character the DNA double helix is stable and biologically active only in salty aqueous media where its charge is compensated by solvent counterions. Monovalent metal ions are ubiquitous in DNA environment and they are usually considered as the possible driving force of sequence-dependent modulations of DNA structure that make it recognizable by proteins. In an effort to directly examine this hypothesis, MD simulations of DNA in a water drop surrounded by vacuum were carried out, which relieves the requirement of charge neutrality. Surprisingly, with zero concentration of counterions a dodecamer DNA duplex appears metastable and its structure remains similar to that observed in experiments.

  12. Clinical and histopathologic features of biofilm-associated chronic rhinosinusitis with nasal polyps in Chinese patients

    Institute of Scientific and Technical Information of China (English)

    SUN Yan; LI Ying; ZHOU Bing; WANG Cheng-shuo; HUANG Qian; ZHANG Qi; HAN Ye-hua; DAI Wei; SUN Yi-lin; FAN Er-zhong

    2012-01-01

    Background Biofilms have given new insights to the understanding of pathogenesis of chronic rhinosinusitis (CRS).However,the link between biofilms formation and local inflammatory response remains poorly defined in CRS with nasal polys.The aim of this study was to determine the potential association of the presence of biofilms in the nasal mucosal tissues with clinical features in Chinese patients,which had CRS with nasal polyps (CRSwNP).Methods A total of 19 patients with CRSwNP and 12 patients with non-CRS were subjected to endoscopic surgery and their nasal mucosal tissue specimens were examined histologically and by scanning electron microscopy (SEM).Their demographic and clinical features were recorded.Results Thirteen (68.4%) out of the 19 specimens from patients with CRSwNP,but none from control patients,were positive for biofilms that displayed typical characteristics of bacterial and fugal structures.The presence of biofilms in the nasal mucosal tissues was associated with significantly greater values of purulent nasal discharge and preoperative Lund-Kennedy scores,higher levels of serum total IgE and percentages of subjects with endoscopic surgery (ESS)history in patients with CRSwNP,and more severe inflammation in the nasal mucosal tissues of patients with CRSwNP.Conolusion Our study demonstrated the presence of biofilms in the nasal mucosal tissues of many patients,contributing to the understanding of the pathogenic process of CRSwNP in Chinese patients.

  13. The Epidemiological and Clinical Aspects of Nasal Polyps that Require Surgery

    Directory of Open Access Journals (Sweden)

    Ahmad Meymane Jahromi

    2011-01-01

    Full Text Available Introduction: The objective of this retrospective cross-sectional study was to obtain epidemiological data from the charts of 297 patients with nasal polyposis who were operated on in a referral hospital in Mashhad and to determine the frequency of the presenting symptoms of nasal polyps.  Materials and Methods: The variables recorded included age, gender, the presence of asthma or allergic rhinitis, family history, and previous treatments. We studied the main symptoms of nasal polyposis (nasal obstruction, rhinorrhea, anosmia, headache, epistaxis, snoring, and so on, as well as ear problems and facial deformity.  Results: Nasal polyposis affects men (60.3% more frequently, at a mean age of 39.5 years. The most frequent symptom was nasal blockage (81.1 % followed by rhinorrhea (37.7%. A total of 11.1% of the patients had a history of epistaxis. Asthma was found in 10.4% of patients with nasal polyposis and the ears were affected in 5.1% of patients. In all, 7.4% of patients had first-degree relatives who suffered from asthma or allergic rhinitis.  Conclusion: This study highlights the need for large-scale epidemiologic research exploring the prevalence and incidence of nasal polyposis in Iran.

  14. A death certificate analysis of nasal cancer among furniture workers in North Carolina.

    Science.gov (United States)

    Brinton, L A; Blot, W J; Stone, B J; Fraumeni, J F

    1977-10-01

    A case-control study of nasal cancer, based on death certificate statements on occupation in North Carolina counties with furniture-manufacturing industries, revealed a 4-fold excess risk linked to this occupation. Although woodworking exposures have been associated with nasal adenocarcinomas in several areas of the world, this is the first report of such a relationship in the United States.

  15. Thiolated polycarbophil as an adjuvant for permeation enhancement in nasal delivery of antisense oligonucleotides.

    Science.gov (United States)

    Vetter, A; Martien, R; Bernkop-Schnürch, A

    2010-03-01

    The purpose of this study was to investigate the effect of thiolated polycarbophil as an adjuvant to enhance the permeation and improve the stability of a phosphorothioate antisense oligonucleotide (PTO-ODN) on the nasal mucosa. Polycarbophil-cysteine (PCP-Cys) was synthesized by the covalent attachment of L-cysteine to the polymeric backbone. Cytotoxicity tests were examined on human nasal epithelial cells from surgery of nasal polyps confirmed by histological studies. Deoxyribonuclease I activity in respiratory region of the porcine nasal cavity was analyzed by an enzymatic assay. The enzymatic degradation of PTO-ODNs on freshly excised porcine nasal mucosa was analyzed and protection of PCP-cysteine toward DNase I degradation was evaluated. Permeation studies were performed in Ussing-type diffusion chambers. PCP-Cys/GSH did not arise a remarkable mortal effect. Porcine respiratory mucosa was shown to possess nuclease activity corresponding to 0.69 Kunitz units/mL. PTO-ODNs were degraded by incubation with nasal mucosa. In the presence of 0.45% thiolated polycarbophil and 0.5% glutathione (GSH), this degradation process could be lowered. In the presence of thiolated polycarbophil and GSH the uptake of PTO-ODNs from the nasal mucosa was 1.7-fold improved. According to these results thiolated polycarbophil/GSH might be a promising excipient for nasal administration of PTO-ODNs.

  16. Downregulation of peroxisome proliferator-activated receptors (PPARs in nasal polyposis

    Directory of Open Access Journals (Sweden)

    Adner Mikael

    2005-11-01

    Full Text Available Abstract Background Peroxisome proliferator-activated receptor (PPAR α, βδ and γ are nuclear receptors activated by fatty acid metabolites. An anti-inflammatory role for these receptors in airway inflammation has been suggested. Methods Nasal biopsies were obtained from 10 healthy volunteers and 10 patients with symptomatic allergic rhinitis. Nasal polyps were obtained from 22 patients, before and after 4 weeks of local steroid treatment (fluticasone. Real-time RT-PCR was used for mRNA quantification and immunohistochemistry for protein localization and quantification. Results mRNA expression of PPARα, PPARβδ, PPARγ was found in all specimens. No differences in the expression of PPARs were obtained in nasal biopsies from patients with allergic rhinitis and healthy volunteers. Nasal polyps exhibited lower levels of PPARα and PPARγ than normal nasal mucosa and these levels were, for PPARγ, further reduced following steroid treatment. PPARγ immunoreactivity was detected in the epithelium, but also found in smooth muscle of blood vessels, glandular acini and inflammatory cells. Quantitative evaluation of the epithelial immunostaining revealed no differences between nasal biopsies from patients with allergic rhinitis and healthy volunteers. In polyps, the PPARγ immunoreactivity was lower than in nasal mucosa and further decreased after steroid treatment. Conclusion The down-regulation of PPARγ, in nasal polyposis but not in turbinates during symptomatic seasonal rhinitis, suggests that PPARγ might be of importance in long standing inflammations.

  17. Reshaping of the Anterior Nasal Spine: An Important Step in Rhinoplasty

    Science.gov (United States)

    Boccieri, Armando; Pascali, Michele

    2016-01-01

    Background: The importance of analysis of the nasal spine should not be underestimated in the correct planning of rhinoplasty. Deformations in position with respect to the midline and/or in size are often present, and their correction to ensure harmony between the spine and the other components of the nasal pyramid constitutes a key step in rhinoplasty that can lead to excellent results. Methods: The study includes 160 patients who underwent surgical treatment of the anterior nasal spine with or without other techniques of nasal reshaping. Eighty-seven of these patients presented with hyperplasia of the nasal spine, 43 with hypoplasia, and 30 with deviation. A combination of deviation and hyperplasia was present in 15 cases. Results: No patients developed postoperative complications. Five patients who underwent anterior nasal spine reduction reported postoperative numbness in the premaxillary area, but sensitivity was fully regained within 4 months after surgery in these patients. All the patients reported postoperative improvement of nasal airflow. A total of 142 patients considered their postoperative aesthetic result as excellent and 18 as good. Conclusion: The simplicity of the surgical procedures performed on the nasal spine and the marked aesthetic improvements thus achieved suggest that greater attention should be paid to this anatomical region.

  18. Early nasal continuous positive airway pressure in a cohort of the smallest infants in Denmark

    DEFF Research Database (Denmark)

    Hansen, Bo M; Esbjørn, Barbara Hoff; Greisen, G;

    2004-01-01

    To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period.......To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period....

  19. Absorption and metabolism of the absorption enhancer didecanoylphosphatidylcholine in rabbit nasal epithelium in vivo

    DEFF Research Database (Denmark)

    Vermehren, C.; Johansen, P.B.; Hansen, Harald S.

    1997-01-01

    The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-H]choline in rabbit nasal mucosa...

  20. Acoustic Rhinometry (AR): An alternative method to image nasal airway geometry

    DEFF Research Database (Denmark)

    Straszek, Sune

    2007-01-01

    In acoustic rhinometry (AR) a soud pulse enters the nasal cavity, where it is reflected due to changes in the local impedances. From the incident and reflected sound signal we use the Ware-Aki algorithm to calculate an area-distance relationship. The method has been validated in nasal cavity mode...

  1. Development and characterization of mucoadhesive in situ nasal gel of midazolam prepared with Ficus carica mucilage.

    Science.gov (United States)

    Basu, Shyamoshree; Bandyopadhyay, Amal Kumar

    2010-09-01

    The objective of the present study was to prepare mucoadhesive in situ nasal gels with mucilage isolated from fig fruits (Ficus carica, family: Moraceae) containing midazolam hydrochloride. Nasal gels of midazolam were prepared using three different concentrations (0.5%, 1.0% and 1.5% w/v) of F. carica mucilage (FCM) and synthetic polymers (hydroxypropylmethyl cellulose and Carbopol 934). Evaluation of FCM showed that it was as safe as the synthetic polymers for nasal administration. In situ gels were prepared with mixture Pluronic F127 and mucoadhesive agents. Evaluation of the prepared gels was carried out, including determination of viscosity, texture profile analysis and mucoadhesive strength. In vitro drug permeation study was conducted with the gels prepared with and without permeation enhancer (0.5% w/v sodium taurocholate) using excised goat nasal mucosa. In vitro permeation profiles were evaluated, and histological study of nasal mucosae before and after permeation study was also conducted to determine histological change, if any. In vivo experiments conducted in rabbits further confirmed that in situ nasal gels provided better bioavailability of midazolam than the gels prepared from synthetic mucoadhesive polymers. It was observed that the nasal gel containing 0.5% FCM and 0.5% sodium taurocholate exhibited appropriate rheological, mechanical and mucoadhesive properties and showed better drug release profiles. Moreover, this formulation produced no damage to the nasal mucosa that was used for the permeation study, and absolute bioavailability was also higher compared to gels prepared from synthetic polymers.

  2. Sinonasal Headaches and Post-Operative Outcomes after Septoplasty in Patients with Nasal Septal Deviation

    Directory of Open Access Journals (Sweden)

    Ali Ghazipour

    2011-03-01

    Headache is one of the most common symptoms in patients with nasal anatomical abnormalities such as septal deviation and usually responds well to surgical treatment. More studies with long-term follow-ups seems to be inevitable to determine the relationship between headaches and nasal anatomical abnormalities, accurate surgical results in patients’ recovery and the recurrence rate of headaches.

  3. The nasal valve : New Methods for Reconstruction, Suspension and Objective measurements

    NARCIS (Netherlands)

    Menger, D.J.

    2014-01-01

    This thesis is composed of 3 chapters. The first chapter deals with cartilaginous implants for the reconstruction of the nasal valve region and the nasal skeleton. In the first part of this chapter long-term results of homologous irradiated costal cartilage grafts in rhinoplasty are discussed for ni

  4. Pendant-Drop Surface-Tension Measurement On Molten Metal

    Science.gov (United States)

    Man, Kin Fung; Thiessen, David

    1996-01-01

    Method of measuring surface tension of molten metal based on pendant-drop method implemented in quasi-containerless manner and augmented with digital processing of image data. Electrons bombard lower end of sample rod in vacuum, generating hanging drop of molten metal. Surface tension of drop computed from its shape. Technique minimizes effects of contamination.

  5. Delayed Frost Growth on Jumping-Drop Superhydrophobic Surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Boreyko, Jonathan B [ORNL; Collier, Pat [ORNL

    2013-01-01

    Self-propelled jumping drops are continuously removed from a condensing superhydrophobic surface to enable a micrometric steady-state drop size. Here, we report that subcooled condensate on a chilled superhydrophobic surface are able to repeatedly jump off the surface before heterogeneous ice nucleation occurs. Frost still forms on the superhydrophobic surface due to ice nucleation at neighboring edge defects, which eventually spreads over the entire surface via an inter-drop frost wave. The growth of this inter-drop frost front is shown to be up to three times slower on the superhydrophobic surface compared to a control hydrophobic surface, due to the jumping-drop effect dynamically minimizing the average drop size and surface coverage of the condensate. A simple scaling model is developed to relate the success and speed of inter-drop ice bridging to the drop size distribution. While other reports of condensation frosting on superhydrophobic surfaces have focused exclusively on liquid-solid ice nucleation for isolated drops, these findings reveal that the growth of frost is an inter-drop phenomenon that is strongly coupled to the wettability and drop size distribution of the surface. A jumping-drop superhydrophobic condenser was found to be superior to a conventional dropwise condenser in two respects: preventing heterogeneous ice nucleation by continuously removing subcooled condensate, and delaying frost growth by minimizing the success of interdrop ice bridge formation.

  6. 14 CFR 29.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 29.727 Section 29.727 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION....727 Reserve energy absorption drop test. The reserve energy absorption drop test must be conducted...

  7. 14 CFR 27.727 - Reserve energy absorption drop test.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Reserve energy absorption drop test. 27.727 Section 27.727 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Reserve energy absorption drop test. The reserve energy absorption drop test must be conducted as...

  8. Inverse Leidenfrost Effect: Levitating Drops on Liquid Nitrogen.

    Science.gov (United States)

    Adda-Bedia, M; Kumar, S; Lechenault, F; Moulinet, S; Schillaci, M; Vella, D

    2016-05-01

    We explore the interaction between a liquid drop (initially at room temperature) and a bath of liquid nitrogen. In this scenario, heat transfer occurs through film-boiling: a nitrogen vapor layer develops that may cause the drop to levitate at the bath surface. We report the phenomenology of this inverse Leidenfrost effect, investigating the effect of the drop size and density by using an aqueous solution of a tungsten salt to vary the drop density. We find that (depending on its size and density) a drop either levitates or instantaneously sinks into the bulk nitrogen. We begin by measuring the duration of the levitation as a function of the radius R and density ρd of the liquid drop. We find that the levitation time increases roughly linearly with drop radius but depends weakly on the drop density. However, for sufficiently large drops, R ≥ Rc(ρd), the drop sinks instantaneously; levitation does not occur. This sinking of a (relatively) hot droplet induces film-boiling, releasing a stream of vapor bubbles for a well-defined length of time. We study the duration of this immersed-drop bubbling finding similar scalings (but with different prefactors) to the levitating drop case. With these observations, we study the physical factors limiting the levitation and immersed-film-boiling times, proposing a simple model that explains the scalings observed for the duration of these phenomena, as well as the boundary of (R,ρd) parameter space that separates them. PMID:27054550

  9. Effect of marbofloxacin on Haemophilus parasuis nasal carriage.

    Science.gov (United States)

    Vilalta, Carles; Galofré, Nuria; Aragon, Virginia; Pérez de Rozas, Ana María; Fraile, Lorenzo

    2012-09-14

    Haemophilus parasuis is a colonizer of the upper respiratory tract and the causative agent of Glässer's disease in swine. This study focused on the nasal carriage of H. parasuis after treatment with marbofloxacin. Three marbofloxacin treatments (three doses of 2mg/kg body weight [bw] every 24h, two doses of 4 mg/kg bw every 48 h and 8 mg/kg bw in one single shot) were used and all of them reduce significantly (pmarbofloxacin/kg bw in one shot was further studied in a farm with clinical cases of Glässer's disease using a longitudinal study. Statistically significant reduction of nasal carriage of H. parasuis was detected during the first week after treatment in comparison with the control group. However, a clear relationship between the minimum inhibitory concentration (MIC) of the different strains, their putative virulence or the treatment group (antibiotic or control) from which they were isolated was not detected. Finally, the effect induced by the antibiotic treatment on the bacterial strains seemed to be transitory, since diverse H. parasuis strains (with high and low marbofloxacin MICs) were observed 7 days after finishing the treatment.

  10. Properties and Mechanobiological Behavior of Bovine Nasal Septum Cartilage.

    Science.gov (United States)

    Correro-Shahgaldian, Maria Rita; Introvigne, Jasmin; Ghayor, Chafik; Weber, Franz E; Gallo, Luigi M; Colombo, Vera

    2016-05-01

    Bovine nasal septum (BNS) is a source of non-load bearing hyaline cartilage. Little information is available on its mechanical and biological properties. The aim of this work was to assess the characteristics of BNS cartilage and investigate its behavior in in vitro mechanobiological experiments. Mechanical tests, biochemical assays, and microscopic assessment were performed for tissue characterization. Compressions tests showed that the tissue is viscoelastic, although values of elastic moduli differ from the ones of other cartilaginous tissues. Water content was 78 ± 1.4%; glycosaminoglycans and collagen contents-measured by spectrophotometric assay and hydroxyproline assay-were 39 ± 5% and 25 ± 2.5% of dry weight, respectively. Goldner's Trichrome staining and transmission electron microscopy proved isotropic cells distribution and results of earlier cell division. Furthermore, gene expression was measured after uniaxial compression, showing variations depending on compression time as well as trends depending on equilibration time. In conclusion, BNS has been characterized at several levels, revealing that bovine nasal tissue is regionally homogeneous. Results suggest that, under certain conditions, BNS could be used to perform in vitro cartilage loading experiments.

  11. RANS and LES simulations of the airflow through nasal cavities

    Science.gov (United States)

    Lamberti, Giacomo

    2015-11-01

    The prediction of detailed flow patterns in nasal cavities using computational fluid dynamics (CFD) can provide essential information on the potential relationship between patient-specific geometrical characteristics and health problems. The long-term goal of the OpenNOSE project is to develop a reliable open-source computational tool based on the OpenFOAM CFD toolbox that can assist surgeons in their daily practice. The objective of this study was to investigate the effect of the turbulence model and boundary conditions on simulations of the airflow in nasal cavities. The geometry, including paranasal sinuses, was reconstructed from a carefully selected CT scan, and RANS and LES simulations were carried out for steady inspiration and expiration. At a flow rate near 20 l/min, the flow is laminar in most of the domain. During the inspiration phase, turbulence develops in nasopharynx and oropharynx regions; during the expiration phase, another vortical region is observed down the nostrils. A comparison between different boundary conditions suggests the use of a total pressure condition, or alternatively a uniform velocity, at the inlet and outlet. In future work the same geometry will be used for setting up a laboratory experiment, intended to cross-validate the numerical results.

  12. Angular vessels as a new vascular pedicle of an island nasal chondromucosal flap: Anatomical study and clinical application

    OpenAIRE

    HOU, DIANJU; Fang, Lin; Zhao, Zhenmin; ZHOU, CHUANDE; YANG, MINGYONG

    2012-01-01

    Successful eyelid reconstructions have been reported when using an axial nasal chondromucosal flap based on the dorsal nasal artery. The present study aimed to present a detailed anatomical description of the blood supply of the lateral nasal region and the angular artery, in order to propose the angular vessels as a new vascular pedicle for the island nasal chondromucosal flap. A total of 11 cadavers (22 hemi-faces) were examined. Observations with regard to the origin, course and distributi...

  13. Westernization of the Asian Nose by Augmentation of the Retropositioned Anterior Nasal Spine With an Injectable Filler

    OpenAIRE

    Tanaka, Yohei; Matsuo, Kiyoshi; Yuzuriha, Shunsuke

    2011-01-01

    Objective: The aging nose presents as a drooping nasal tip secondary to atrophy of the underlying bony support with a relatively prominent dorsal hump. We hypothesized that low nasal tip projection in the Asian nose may be secondary to the retropositioned anterior nasal spine (ANS) as well. Therefore, we investigated how filler injection between the medial crura and the retropositioned ANS affects the nasal shape. Methods: Local anesthetic was injected on the ANS for analgesia and simulation ...

  14. PROGRAM DROP: A computer program for prediction of evaporation from freely falling multicomponent drops

    Energy Technology Data Exchange (ETDEWEB)

    Gavin, P.M. [Gavin Consulting, Newark, OH (United States)

    1996-12-01

    PROGRAM DROP consists of a series of FORTRAN routine which together are used to model the evaporation of a freely falling, multicomponent drop composed of an arbitrary number of volatile species and a single nonvolatile, inert component. The physics underlying the model are clearly identified, and the model`s relationship to previous work in the literature is described. Test cases are used to illustrate the viability of the model and to highlight its potential usefulness in the accurate prediction of multicomponent droplet vaporization in a variety of applications.

  15. Clinical value of CT scan in diagnosing nasal malignant lymphoma (a report of 11 cases)

    International Nuclear Information System (INIS)

    Objective: To investigate the value of CT in diagnosing nasal malignant lymphoma. Methods: CT findings of 11 patients with nasal malignant lymphoma proved pathologically were reviewed retrospectively. Results: The lesions pathologically diagnosed were all NHL and 9 cases were peripheral T-cell lymphoma. CT scan showed: (1) Lesions arose mainly from nasal vestibule or anterior part of nasal cavity, consisting of hyperplasia type 2 cases, infiltration type 3 cases, and hyperplasia-infiltration (mixed) type 6 cases. (2) Density of mass of hyperplasia type was relatively homogeneous, presenting as isodensity or slight hyper-density, while infiltration and mixed type appeared inhomogeneous. (3) Slight bony erosion was found in 8 cases, characterized by 'mouse nibbled' or cribriform bony absorption. (4) Adjacent structures were usually involved, and lesions might be polycentric. (5) Lesions often shrank or disappeared after radiotherapy. Conclusion: CT findings of nasal malignant lymphoma are relatively characteristic. It can clearly demonstrate the extent of lesion

  16. Unexpected nasal changes in rats related to reflux after gavage dosing.

    Science.gov (United States)

    Damsch, Siegrid; Eichenbaum, Gary; Looszova, Adriana; Lammens, Lieve; Feyen, Bianca; Van den Bulck, Kathleen; Knight, Elaine; Kelley, Michael; Tonelli, Alfred

    2011-02-01

    In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasal cavity was included for examination. Histology revealed extensive necrosis and purulent inflammation within the nasal passages, indicative of direct irritation. Since posterior nasal regions were most affected, with food material present within the inflammatory exudates, reflux and retrograde aspiration of irritant material (possibly stomach contents with test formulation) into the nasal cavity were suspected. Lowering the dose volume and fasting the rats prior to gavage dosing substantially reduced the respiratory effects and mortality. The current article focuses on the histological changes in the nasal cavity indicative of gavage-related reflux and provides guidance on differentiation between technical gavage error and gavage-related reflux. PMID:21422260

  17. Anatomia cirúrgica do acesso nasal transesfenoidal para tumores da hipófise Surgical anatomy of the nasal transphenoidal approach for pituitary tumors

    Directory of Open Access Journals (Sweden)

    Murilo S. Meneses

    1997-09-01

    Full Text Available Foram analisadas diferentes medidas relacionadas ao acesso nasal transesfenoidal em 18 hemicabeças de cadáveres com o objetivo de estudar os limites e vantagens dessa via. Foram obtidos os seguintes valores médios (mm para as principais medidas: diâmetro maior da narina 15,18; altura da cavidade nasal 44,11; distância narina - sela turca 71,71. Esses valores demonstram ser o acesso nasal uma via ampla e direta à sela turca. O presente estudo demonstrou também ser possível nesse acesso preservar o septo cartilágino e outras estruturas que são usualmente lesadas no acesso sublabial.Different distances related to the nasal transphenoidal approach were measured on the hemiheads of eighteen cadavers in order to study its limits and advantages. The main mean measures obtained (mm were: major diameter of the nostril 15.18; height of the nasal cavity 44.11; nostril-sella turcica distance 71.71. These results show that the nasal approach is wide and direct to the sella turcica. The present study demonstrate the possibility of preservation of the cartilaginous septum and other structures which are usually damaged when the sublabial approach is employed.

  18. Electrically induced drop detachment and ejection

    Science.gov (United States)

    Cavalli, Andrea; Preston, Daniel J.; Tio, Evelyn; Martin, David W.; Miljkovic, Nenad; Wang, Evelyn N.; Blanchette, Francois; Bush, John W. M.

    2016-02-01

    A deformed droplet may leap from a solid substrate, impelled to detach through the conversion of surface energy into kinetic energy that arises as it relaxes to a sphere. Electrowetting provides a means of preparing a droplet on a substrate for lift-off. When a voltage is applied between a water droplet and a dielectric-coated electrode, the wettability of the substrate increases in a controlled way, leading to the spreading of the droplet. Once the voltage is released, the droplet recoils, due to a sudden excess in surface energy, and droplet detachment may follow. The process of drop detachment and lift-off, prevalent in both biology and micro-engineering, has to date been considered primarily in terms of qualitative scaling arguments for idealized superhydrophobic substrates. We here consider the eletrically-induced ejection of droplets from substrates of finite wettability and analyze the process quantitatively. We compare experiments to numerical simulations and analyze how the energy conversion efficiency is affected by the applied voltage and the intrinsic contact angle of the droplet on the substrate. Our results indicate that the finite wettability of the substrate significantly affects the detachment dynamics, and so provide new rationale for the previously reported large critical radius for drop ejection from micro-textured substrates.

  19. Impact Dynamics of Oxidized Liquid Metal Drops

    CERN Document Server

    Xu, Qin; Jaeger, Heinrich M

    2013-01-01

    With exposure to air, many liquid metals spontaneously generate an oxide layer on their surface. In oscillatory rheological tests, this skin is found to introduce a yield stress that typically dominates the elastic response but can be tuned by exposing the metal to hydrochloric acid solutions of different concentration. We systematically studied the normal impact of eutectic gallium-indium (eGaIn) drops under different oxidation conditions and show how this leads to two different dynamical regimes. At low impact velocity (or low Weber number), eGaIn droplets display strong recoil and rebound from the impacted surface when the oxide layer is removed. In addition, the degree of drop deformation or spreading during the impact is controlled by the oxide skin. We show that the scaling law known from ordinary liquids for the maximum spreading radius as a function of impact velocity can still be applied to the case of oxidized eGaIn if an effective Weber number $We^{\\star}$ is employed that uses an effective surface...

  20. Experimental Analysis of a Vertical Drop Shaft

    Directory of Open Access Journals (Sweden)

    Giuseppe Del Giudice

    2013-09-01

    Full Text Available An experimental campaign is undertaken in order to investigate the hydraulic features of a vertical drop shaft, also considering the influence of a venting system consisting of a coaxial vertical pipe, projecting within the drop shaft with different plunging rates. Three different flow regimes are observed: a “weir flow” for very low head values, where the flow profile is subject to the atmospheric pressure; a “full flow” for high head values, where water flows in a pressurized regime along the whole shaft; and a “transitional flow” for intermediate water head values. Weir flow and full flow can be experimentally investigated under steady-state conditions, whereas transitional flow is a pulsating condition, alternately switching from full flow to weir flow. Considering some significant geometric parameters, a head-discharge relation is sought both for the non-vented and for the vented configurations, by means of an energy balance equation, with specific assumptions about intake losses.

  1. The use of nasal mupirocin ointment to prevent Staphylococcus aureus bacteraemias in haemodialysis patients: an analysis of cost- effectiveness

    NARCIS (Netherlands)

    J.R. Boelaert; M. A. Geernaert; C.A. Godard (Claudine); H.W. van Landuyt; Y.A. de Baere

    1991-01-01

    textabstractNasal carriage of Staphylococcus aureus is a risk factor for the development of infections caused by S. aureus in haemodialysis patients. This study compared the incidence of bacteraemia caused by S. aureus during 6 months of use of nasal 2% calcium mupirocin ('Nasal Bactroban') 3-times

  2. Reliability of fetal nasal bone length measurement at 11–14 weeks of gestation

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    Suwanrath Chitkasaem

    2013-01-01

    Full Text Available Abstract Background Nasal bone assessment has been incorporated into Down syndrome screening in first trimester. Several studies have established the normal reference values for fetal nasal bone length in the first trimester, which were found to be varied by population. However, the study on reliability of nasal bone length measurement was limited with contradictory results. This study aimed to investigate the reliability of fetal nasal bone length measurement at 11–14 weeks of gestation in the Thai population. Methods A total of 111 pregnant women at 11–14 weeks of gestation attending for the routine first-trimester ultrasound examination were recruited. Each case was measured separately by two examiners. Examiner 1 performed the first measurement in all cases; any of the other 5 examiners consecutively performed the second measurement. Three independent measurements were performed by each examiner and they were blinded to the results of the others. Intraobserver and interobserver variabilities were evaluated with the intraclass correlation coefficient (ICC. Results Nasal bone measurement was successfully performed in 106/111 cases (95.5% by at least one examiner; 89 cases were performed by two examiners. The intraobserver variability was excellent for all examiners (ICC, 0.840-0.939. The interobserver variability between different pairs of examiners varied from moderate to excellent (ICC, 0.467-0.962. The interobserver variability between examiner 1 and any other examiner was good (ICC, 0.749. The Bland-Altman plot of the interobserver differences of nasal bone length measurements between examiner 1 and any other examiner showed good agreement. Conclusions The reliability of the fetal nasal bone length measurement at 11–14 weeks of gestation was good. The nasal bone length measurement was reproducible. Ethnicity has an effect on fetal nasal bone length, but reliability of nasal bone length measurement is critical to accuracy of

  3. Herpes viruses and human papilloma virus in nasal polyposis and controls

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    Dimitrios Ioannidis

    2015-12-01

    Full Text Available ABSTRACT INTRODUCTION: Chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. Contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic rhinosinusitis. OBJECTIVE: To compare the prevalence of human herpes viruses (1-6 and Human Papilloma Virus in adult patients with chronic rhinosinusitis with nasal polyps and healthy controls. METHODS: Viral DNA presence was evaluated by real-time polymerase chain reaction application to nasal polyps specimens from 91 chronic rhinosinusitis with nasal polyps patients and nasal turbinate mucosa from 38 healthy controls. RESULTS: Epstein-Barr virus positivity was higher in nasal polyps (24/91; 26.4% versus controls (4/38; 10.5%, but the difference did not reach significance (p = 0.06. Human herpes virus-6 positivity was lower in nasal polyps (13/91; 14.29% versus controls (10/38; 26.32%,p = 0.13. In chronic rhinosinusitis with nasal polyps group, 1 sample was herpes simplex virus-1-positive (1/91; 1.1%, and another was cytomegalovirus-positive (1/91; 1.1%, versus none in controls. No sample was positive for herpes simplex virus-2, varicella-zoster virus, high-risk-human papilloma viruses (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and low-risk-human papilloma viruses (6, 11. CONCLUSION: Differences in Epstein-Barr virus and human herpes virus-6 positivity among patients with chronic rhinosinusitis with nasal polyps and healthy controls are not statistically significant, weakening the likelihood of their implication in chronic rhinosinusitis with nasal polyps pathogenesis.

  4. Evidence for intranasal anti-nuclear autoantibodies in Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    Tan, Bruce K.; Li, Quan-Zhen; Suh, Lydia; Kato, Atsushi; Conley, David B.; Chandra, Rakesh K.; Zhou, Jinchun; Norton, James; Carter, Roderick; Hinchcliff, Monique; Harris, Kathleen; Peters, Anju; Grammer, Leslie C.; Kern, Robert C.; Mohan, Chandra; Schleimer, Robert P.

    2011-01-01

    BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal passage and paranasal sinuses characterized by Th2 biased inflammation with elevated levels of BAFF, B-lymphocytes, and immunoglobulins. Since high levels of BAFF are associated with autoimmune diseases, we assessed for evidence of autoimmunity in patients with CRS. OBJECTIVES The objective of this study was to investigate for the presence of autoantibodies in sinonasal tissue from patients with CRS. METHODS Standardized nasal tissue specimens were collected from patients with CRS and control subjects and assayed for immunoglobulin production, autoantibody levels, tissue distribution of immunoglobulins and binding potential of antibodies in nasal tissue using a multiplexed autoantibody microarray, ELISA and immunofluoresence. RESULTS Elevated levels of several specific autoantibodies were found in nasal polyp tissue in comparison with control tissue and inflamed tissue from non-polypoid CRS (CRSsNP) (p<0.05). In particular, nuclear-targeted autoantibodies such as anti-dsDNA IgG and IgA antibodies were found at elevated levels in nasal polyps (p<0.05) and particularly in nasal polyps from patients requiring revision surgery for recurrence. Direct immunofluorescence staining demonstrated diffuse epithelial and sub-epithelial deposition of IgG and increased numbers of IgA secreting plasma cells not seen in control nasal tissue. CONCLUSIONS Autoantibodies, particularly those against nuclear antigens, are present at locally elevated levels in nasal polyps. The presence of autoantibodies suggests that the microenvironment of a nasal polyp promotes the expansion of self-reactive B-cell clones. While the pathogenicity of these antibodies remains to be elucidated, the presence of elevated anti-dsDNA antibodies is associated with a clinically more aggressive form of CRSwNP requiring repeated surgery. PMID:21996343

  5. Impact of nasal obstruction on sleep quality: a community-based study of women.

    Science.gov (United States)

    Bengtsson, Caroline; Jonsson, Lars; Holmström, Mats; Svensson, Malin; Theorell-Haglöw, Jenny; Lindberg, Eva

    2015-01-01

    The aim of the study was to analyse the impact of self-reported nasal obstruction on sleep quality in women. A community-based sample of 400 women underwent a full night of polysomnography. Airway diseases, allergies and sleep-related symptoms were assessed by questionnaires. Women with subjective nasal obstruction were subdivided into three groups: persistent nasal obstruction (PNO, n = 46), hay fever (n = 88) and nasal obstruction at night (NON, n = 30). Sleep problems and related daytime symptoms were most prevalent among women with NON. After adjusting for age, BMI, smoking and asthma, NON was an independent predictor of 'Difficulties inducing sleep due to nasal obstruction' [adjusted odds ratio (95 % CI): 89.5 (27.0-296.7)], 'Snoring' [4.2 (1.7-10.2)], 'Sweating at night' [2.6 (1.1-6.1)], 'Difficulties maintaining sleep' [2.7 (1.2-6.2)], and 'Waking up hastily gasping for breath' [32.2 (8.7-119.1)]. 'Dry mouth on awakening' [7.7 (3.2-18.4)], 'Waking up unrefreshed' [2.7 (1.2-6.0)], 'Excessive daytime sleepiness' [2.6 (1.1-6.0)], and 'Daytime nasal obstruction' [12.2 (4.8-31.2)] were also associated with NON. Persistent nasal obstruction and hay fever were both associated with some reported sleep problems due to an overlap with NON. When women with NON were excluded, only 'Daytime nasal obstruction' was still significantly associated with PNO, while hay fever was associated with 'Daytime nasal obstruction' and 'Waking up hastily gasping for breath'. There were no significant differences in objectively measured sleep variables between any of the three subgroups and the study cohort. Self-reported nasal obstruction at night in women has a significant effect on several subjective day- and nighttime symptoms, but it does not appear to affect objectively measured sleep quality. PMID:24792065

  6. Processing nasals with and without consecutive context phonemes: Evidence from explicit categorization and the N100

    Directory of Open Access Journals (Sweden)

    Heidrun eBien

    2013-01-01

    Full Text Available With neurophysiological (N100 and explicit behavioural measures (two-alternative forced-choice categorization, we investigated how the processing of nasal segments of German is affected by following context phonemes and their place of articulation. We investigated pre-lexical processing, with speech stimuli excised from naturally spoken utterances. Participants heard nasals (/n/, /m/, and place-assimilated /n’/, both with and without a subsequent context phoneme. Context phonemes were voiced or voiceless, and either shared or did not share their place of articulation with the nasals. The explicit forced-choice categorization of the isolated nasals showed /n’/ to be in-between the clear categorizations for /n/ and /m/. In early, implicit processing, /m/ had a significantly higher N100 amplitude than both /n/ and /n’/, with, most importantly, no difference between the latter two. When presented in context (e.g., /nb/, /mt/, explicit categorizations were affected by both the nasal and the context phoneme: a consecutive labial led to more M-categorizations, a following alveolar to more N-categorizations. The early processing of the nasal/+context stimuli in the N100 showed strong effects of context, modulated by the type of preceding nasal. Crucially, the context effects on assimilated nasals /n’/ were clearly different to effects on /m/, and indistinguishable from effects on /n/. The grouping of the isolated nasals in the N100 replicates previous findings, using MEG and a different set of stimuli. Importantly, the same grouping was observed in the nasal/+context stimuli. Most models that deal with assimilation are either challenged by the mere existence of phonemic context effects, and/or use mechanisms that rely on lexical information. Our results support the existence, and early activation, of pre-lexical categories for phonemic segments. We suggest that due to experience with assimilation, specific speech-sound categories are flexible

  7. Force-displacement differences in the lower extremities of young healthy adults between drop jumps and drop landings.

    Science.gov (United States)

    Hackney, James M; Clay, Rachel L; James, Meredith

    2016-10-01

    We measured ground reaction force and lower extremity shortening in ten healthy, young adults in order to compare five trials of drop jumps to drop landings. Our dependent variable was the percentage of displacement (shortening) between the markers on the ASIS and second metatarsal heads on each LE, relative to the maximum shortening (100% displacement) for that trial at the point of greatest ground reaction force. We defined this as "percent displacement at maximum force" (%dFmax). The sample mean %dFmax was 0.73%±0.14% for the drop jumps, and 0.47%±0.09% for the drop landings. The mean within-subject difference score was 0.26%±0.20%. Two-tailed paired t test comparing %dFmax between the drop jump and drop landing yielded P=0.002. For all participants in this study, the %dFmax was greater in drop jumps than in drop landings. This indicates that in drop jumps, the point of maximum force and of maximum shortening was nearly simultaneous, compared to drop landings, where the point of maximum shortening followed that of maximum force by a greater proportion. This difference in force to displacement behavior is explained by linear spring behavior in drop jumps, and linear damping behavior in drop landings. PMID:27344129

  8. Tip Streaming from a Drop in the Presence of Surfactants

    International Nuclear Information System (INIS)

    Drop breakup in a linear extensional flow is simulated numerically using a nonlinear model for the surface tension that accounts for maximum packing at the interface. Surface convection sweeps surfactant to the drop poles, where it accumulates and drives the surface tension to near zero. The drop assumes a transient shape with highly pointed tips. From these tips, thin liquid threads are pulled. Subsequently, small, surfactant-rich droplets are emitted from the termini of these threads. The scale of the shed drops depends on the initial surfactant coverage. Dilute initial coverage leads to tip streaming, while high initial coverage leads to the tip dropping breakup mode

  9. Vertical vibration and shape oscillation of acoustically levitated water drops

    Science.gov (United States)

    Geng, D. L.; Xie, W. J.; Yan, N.; Wei, B.

    2014-09-01

    We present the vertical harmonic vibration of levitated water drops within ultrasound field. The restoring force to maintain such a vibration mode is provided by the resultant force of acoustic radiation force and drop gravity. Experiments reveal that the vibration frequency increases with the aspect ratio for drops with the same volume, which agrees with the theoretical prediction for those cases of nearly equiaxed drops. During the vertical vibration, the floating drops undergo the second order shape oscillation. The shape oscillation frequency is determined to be twice the vibration frequency.

  10. Vertical vibration and shape oscillation of acoustically levitated water drops

    Energy Technology Data Exchange (ETDEWEB)

    Geng, D. L.; Xie, W. J.; Yan, N.; Wei, B., E-mail: bbwei@nwpu.edu.cn [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2014-09-08

    We present the vertical harmonic vibration of levitated water drops within ultrasound field. The restoring force to maintain such a vibration mode is provided by the resultant force of acoustic radiation force and drop gravity. Experiments reveal that the vibration frequency increases with the aspect ratio for drops with the same volume, which agrees with the theoretical prediction for those cases of nearly equiaxed drops. During the vertical vibration, the floating drops undergo the second order shape oscillation. The shape oscillation frequency is determined to be twice the vibration frequency.

  11. Deformed liquid marbles: Freezing drop oscillations with powders

    KAUST Repository

    Marston, Jeremy

    2012-09-01

    In this work we show that when a liquid drop impacts onto a fine-grained hydrophobic powder, the final form of the drop can be very different from the spherical form with which it impacts. In all cases, the drop rebounds due to the hydrophobic nature of the powder. However, we find that above a critical impact speed, the drop undergoes a permanent deformation to a highly non-spherical shape with a near-complete coverage of powder, which then freezes the drop oscillations during rebound. © 2012 Elsevier B.V.

  12. Surface Patterns of Parametrically-Excited Sessile Drops

    Science.gov (United States)

    Chang, Chun-Ti; Bostwick, Joshua; Daniel, Susan; Steen, Paul

    2012-11-01

    A mechanically-excited sessile water drop exhibits surface patterns that vary with driving amplitude and frequency. At small amplitudes, drops exhibit axisymmetric wave patterns. At sufficiently large amplitudes and at particular frequencies, symmetry breaks and there appear subharmonically-resonating sectoral and tesseral mode shapes. We report observations from experiment and compare to results from modeling the parametric excitation of the drops. The modeling uses the spectrum and eigenmodes from a linear stability analysis of the inviscid sessile Rayleigh drop with moving/pinned contact-line. Manipulating drop motion can be important to a variety of applications.

  13. Development of a Drop Tester for Portable Electronic Products

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Portable electronic products are susceptible to accidental drop impact which can cause various functional and physical damage. This paper first presents a patent pending drop tester which allows portable electronic products free drop at any orientation and drop height, and then introduces the drop tester experiment setup and its design principle. Using a cellular phone as an experiment object, we obtain some data such as the impact forces, the impact accelerations, and the strain of an interested spot. By analyzing experiment data the influence of impact to products in various states is investigated with the aim to provide help for the design of products and improvement of reliability.

  14. The bounce-splash of a viscoelastic drop

    CERN Document Server

    Hernandez-Sanchez, Federico; Zenit, Roberto

    2008-01-01

    This is an entry for the Gallery of Fluid Motion of the 61st Annual Meeting of the APS-DFD (fluid dynamics videos). This video shows the collision and rebound of viscoelastic drops against a solid wall. Using a high speed camera, the process of approach, contact and rebound of drops of a viscoelastic liquid is observed. We found that these drops first splash, similar to what is observed in Newtonian colliding drops; after a few instants, the liquid recoils, recovering its original drop shape and bounce off the wall.

  15. Quality by design approach for development of suspension nasal spray products: a case study on budesonide nasal suspension.

    Science.gov (United States)

    Chudiwal, Swapnil Sharadkumar; Dehghan, Mohamed Hassan G

    2016-10-01

    The objective of this study was to provide quality by design (QbD) approach for development of suspension type nasal spray products. Quality target product profile (QTPP) of test product budesonide nasal suspension (B-NS) was defined and critical quality attributes (CQAs) were identified. Critical formulation, process and delivery device variables were recognized. Risk assessment was performed by using failure mode and effect analysis (FMEA) methodology. Selected variables were further assessed using a Plackett Burman screening study. A response surface design consisting of the critical factors was used to study the interactions between the study variables. Formulation variable X2: median particle size of budesonide (D50) (µ) has strikingly influenced dissolution (%) (Y1), while D50 droplet size distribution (µm) (Y2) was significantly impacted by formulation variable X1: Avicel RC 591 (%) and process variable X4: homogenization speed (rpm). A design space plot within which the CQAs remained unchanged was established at lab scale. A comprehensive approach for development of B-NS product based on the QbD methodology has been demonstrated. The accuracy and robustness of the model were confirmed by comparability of the predicted value generated by model with the observed value. PMID:26943653

  16. Characterization of biofluids prepared by sessile drop formation.

    Science.gov (United States)

    Esmonde-White, Karen A; Esmonde-White, Francis W L; Morris, Michael D; Roessler, Blake J

    2014-06-01

    Sessile drop formation, also called drop deposition, has been studied as a potential medical diagnostic, but the effects of complex biofluid rheology on the final deposition pattern are not well understood. We studied two model biofluids, blood plasma and synovial fluid, when deposited onto slightly hydrophilic substrates forming a contact angle of 50-90°. Drops were imaged during the evaporation process and geometric properties of the drop, such as contact angle and drop height, were calculated from the images. The resulting dried biofluid drops were then examined using light microscopy and Raman spectroscopy to assess morphological and chemical composition of the dried drop. The effect of substrate contact angle (surface wetting) and fluid concentration was examined. We found that when biofluids are deposited onto slightly hydrophilic surfaces, with a contact angle of 50-90°, a ring-shaped deposit was formed. Analysis of the drying drop's geometric properties indicates that biofluid dynamics follow the piling model of drop formation, as proposed by Deegan et al. The final deposition pattern varied with substrate surface and concentration, as shown by light microscopy photos of dried drops. The chemical composition of the outer ring was minimally affected by substrate surface, but the spatial heterogeneity of protein distribution within the ring varied with concentration. These results indicate that biofluid drop deposition produces ring-shaped deposits which can be examined by multiple analytical techniques. PMID:24757707

  17. Jumps, somersaults, and symmetry breaking in Leidenfrost drops

    Science.gov (United States)

    Chen, Simeng; Bertola, Volfango

    2016-08-01

    When a droplet of water impacts a heated surface, the drop may be observed to bounce. Recently is has been found that small quantities (˜100 ppm) of polymer additives such as polyethylene oxide can significantly increase the maximum bouncing height of drops. This effect has been explained in terms of the reduction of energy dissipation caused by polymer additives during the drop retraction and rebound, resulting in higher mechanical energy available for bouncing. Here we demonstrate, by comparing three types of fluids (Newtonian, shear-thinning, and viscoelastic), that the total kinetic energy carried by low-viscosity Newtonian drops during retraction is partly transformed into rotational kinetic energy rather than dissipated when compared with high-viscosity or non-Newtonian drops. We also show that non-Newtonian effects play little role in the energy distribution during drop impact, while the main effect is due to the symmetry break observed during the retraction of low-viscosity drops.

  18. Metal particle compaction during drop-substrate impact for inkjet printing and drop-casting processes

    Science.gov (United States)

    Clancy, I.; Amarandei, G.; Nash, C.; Glowacki, B. A.

    2016-02-01

    Direct coating methods using metal particles from aqueous solutions or solvent-based inks become central in the roll-to-roll fabrication processes as these methods can lead to continuous or pre-defined conductive layers on a large variety of substrates. For good electrical conductivity, the metal particles have to be brought into contact, and traditionally, additional sintering treatments are required. Such treatments can degrade the sensitive substrates as paper or polymer films. In this study, the possibility of obtaining conductive layers at room temperature is investigated for direct coating methods with an emphasis on drop-casting and inkjet printing. Thus, it is shown that electrical conductive layers can be achieved if the metal particles can compact during the drop-substrate impact interaction. It is theoretically shown that the compaction process is directly related to the particle and ink drop size, the initial fractional particle loading of the ink, solvent viscosity, and drop velocity. The theoretical predictions on compaction are experimentally validated, and the particle compaction's influence on changes in the electrical conductivity of the resulting layers is demonstrated.

  19. A STUDY OF NASAL EOSINOPHILIA IN ASTHMA PATIENTS

    Directory of Open Access Journals (Sweden)

    Ramachandra Prabhu

    2014-05-01

    Full Text Available INTRODUCTION: Asthma is an inflammatory, reversible and progressive disease with episodes of exacerbations. Asthma is now considered as single airway disease and hence comprehensive diagnosis, treatment and follow-up of upper and lower respiratory tract is essential. Both the Nasal and Bronchial mucosa are the elements of united airway disease and Eosinophils measured from this mucosa can be an indirect marker of Airway inflammation in asthma. Eosinophil infiltration is hallmark feature of pathogenesis of asthma which is the trigger for the chronic airway inflammation and these are raised in acute exacerbations. Hence assessing Eosinophil is evidence of serological marker for Airway inflammation (AI. Nasal Smear Eosinophils (NSE is used in asthma with Allergic Rhinitis (AR. This study Using Definition of GINA explores the utility of NSE as marker for management of Asthma. METHODS: In this study 100 patients diagnosed with bronchial asthma attending the outpatient department in KIMS were studied. The severity of asthma was assessed as per FEV1 classification- Adapted from 2007 NHLBI Guidelines for the diagnosis and treatment of Asthma Expert panel Report 3. The Statistical analysis was done with SAS 9.2, SPSS 15.0, Stata 10.1, Med Calc 9.0.1, Systat 12.0 and R environment ver.2.11.1.software. RESULTS: Asthma was more common in Females in this study with M: F ratio of 1.04 and Allergic Rhinitis was found in 55% of Asthmatics. Nasal Eosinophilia was seen in 44% in asthmatic group and 49% in Asthma with Allergic Rhinitis. Absolute Eosinophil count (AEC and Differential count (DC for Eosinophils was almost same in both groups. The Sensitivity of NSE with respect to DC is 70% and in AR group with Asthma and in Asthma group with/without AR it was 38%. Similarly the NSE with respect to AEC was 47% in AR group with Asthma whereas in Asthma group with/without AR it was 38%. CONCLUSIONS: The finding confirms that symptoms, Variable airflow Obstruction and

  20. The dynamics of free liquid drops

    Science.gov (United States)

    Wang, T. G.; Trinh, E. H.; Croonquist, A. P.; Elleman, D. D.

    1988-01-01

    The behavior of rotating and oscillating free liquid drops was studied by many investigators theoretically for many years. More recent numerical treatments have yielded predictions which are yet to be verified experimentally. The purpose is to report the results of laboratory work as well as that of the experiments carried out in space during the flight of Spacelab 3, and to compare it with the existing theoretical studies. Ground-based experiments were attempted as a first approximation to the ideal boundary conditions used by the theoretical treatments by neutralizing the overwhelming effects of the Earth's gravitational field with an outside supporting liquid and with the use of levitation technology. The viscous and inertial loading of such a suspending fluid was found to profoundly effect the results, but the information thus gathered has emphasized the uniqueness of the experimental data obtained in the low-gravity environment of space.