WorldWideScience

Sample records for backstep scanning ion

  1. Kinesin's backsteps under mechanical load

    CERN Document Server

    Hyeon, Changbong; Onuchic, Jose' N

    2009-01-01

    Kinesins move processively toward the plus end of microtubules by hydrolyzing ATP for each step. From an enzymatic perspective, the mechanism of mechanical motion coupled to the nucleotide chemistry is often well explained using a single-loop cyclic reaction. However, several difficulties arise in interpreting kinesin's backstepping within this framework, especially when external forces oppose the motion of kinesin. We review evidence, such as an ATP-independent stall force and a slower cycle time for backsteps, that has emerged to challenge the idea that kinesin backstepping is due to ATP synthesis, i.e., the reverse cycle of kinesin's forward-stepping chemomechanics. Supplementing the conventional single-loop chemomechanics with routes for ATP-hydrolyzing backward steps and nucleotide-free steps, especially under load, gives a better physical interpretation of the experimental data on backsteps.

  2. Scanning Ion Conductance Microscopy of Live Keratinocytes

    Science.gov (United States)

    Hegde, V.; Mason, A.; Saliev, T.; Smith, F. J. D.; McLean, W. H. I.; Campbell, P. A.

    2012-07-01

    Scanning ion conductance microscopy (SICM) is perhaps the least well known technique from the scanning probe microscopy (SPM) family of instruments. As with its more familiar counterpart, atomic force microscopy (AFM), the technique provides high-resolution topographic imaging, with the caveat that target structures must be immersed in a conducting solution so that a controllable ion current may be utilised as the basis for feedback. In operation, this non-contact characteristic of SICM makes it ideal for the study of delicate structures, such as live cells. Moreover, the intrinsic architecture of the instrument, incorporating as it does, a scanned micropipette, lends itself to combination approaches with complementary techniques such as patch-clamp electrophysiology: SICM therefore boasts the capability for both structural and functional imaging. For the present observations, an ICnano S system (Ionscope Ltd., Melbourn, UK) operating in 'hopping mode' was used, with the objective of assessing the instrument's utility for imaging live keratinocytes under physiological buffers. In scans employing cultured HaCaT cells (spontaneously immortalised, human keratinocytes), we compared the qualitative differences of live cells imaged with SICM and AFM, and also with their respective counterparts after chemical fixation in 4% paraformaldehyde. Characteristic surface microvilli were particularly prominent in live cell imaging by SICM. Moreover, time lapse SICM imaging on live cells revealed that changes in the pattern of microvilli could be tracked over time. By comparison, AFM imaging on live cells, even at very low contact forces (scanning speed, however, the intrinsic non-obtrusive nature of

  3. Angular Approach Scanning Ion Conductance Microscopy.

    Science.gov (United States)

    Shevchuk, Andrew; Tokar, Sergiy; Gopal, Sahana; Sanchez-Alonso, Jose L; Tarasov, Andrei I; Vélez-Ortega, A Catalina; Chiappini, Ciro; Rorsman, Patrik; Stevens, Molly M; Gorelik, Julia; Frolenkov, Gregory I; Klenerman, David; Korchev, Yuri E

    2016-05-24

    Scanning ion conductance microscopy (SICM) is a super-resolution live imaging technique that uses a glass nanopipette as an imaging probe to produce three-dimensional (3D) images of cell surface. SICM can be used to analyze cell morphology at nanoscale, follow membrane dynamics, precisely position an imaging nanopipette close to a structure of interest, and use it to obtain ion channel recordings or locally apply stimuli or drugs. Practical implementations of these SICM advantages, however, are often complicated due to the limitations of currently available SICM systems that inherited their design from other scanning probe microscopes in which the scan assembly is placed right above the specimen. Such arrangement makes the setting of optimal illumination necessary for phase contrast or the use of high magnification upright optics difficult. Here, we describe the designs that allow mounting SICM scan head on a standard patch-clamp micromanipulator and imaging the sample at an adjustable approach angle. This angle could be as shallow as the approach angle of a patch-clamp pipette between a water immersion objective and the specimen. Using this angular approach SICM, we obtained topographical images of cells grown on nontransparent nanoneedle arrays, of islets of Langerhans, and of hippocampal neurons under upright optical microscope. We also imaged previously inaccessible areas of cells such as the side surfaces of the hair cell stereocilia and the intercalated disks of isolated cardiac myocytes, and performed targeted patch-clamp recordings from the latter. Thus, our new, to our knowledge, angular approach SICM allows imaging of living cells on nontransparent substrates and a seamless integration with most patch-clamp setups on either inverted or upright microscopes, which would facilitate research in cell biophysics and physiology. PMID:27224490

  4. Bias modulated scanning ion conductance microscopy.

    Science.gov (United States)

    McKelvey, Kim; Perry, David; Byers, Joshua C; Colburn, Alex W; Unwin, Patrick R

    2014-04-01

    Nanopipets are versatile tools for nanoscience, particularly when used in scanning ion conductance microscopy (SICM) to determine, in a noncontact manner, the topography of a sample. We present a new method, applying an oscillating bias between a quasi-reference counter electrode (QRCE) in the SICM nanopipet probe and a second QRCE in the bulk solution, to generate a feedback signal to control the distance between the end of a nanopipet and a surface. Both the amplitude and phase of the oscillating ion current, induced by the oscillating bias and extracted using a phase-sensitive detector, are shown to be sensitive to the probe-surface distance and are used to provide stable feedback signals. The phase signal is particularly sensitive at high frequencies of the oscillating bias (up to 30 kHz herein). This development eliminates the need to physically oscillate the probe to generate an oscillating ion current feedback signal, as needed for conventional SICM modes. Moreover, bias modulation allows a feedback signal to be generated without any net ion current flow, ensuring that any polarization of the quasi reference counter electrodes, electro-osmotic effects, and perturbations of the supporting electrolyte composition are minimized. Both feedback signals, magnitude and phase, are analyzed through approach curve measurements to different surfaces at a range of distinct frequencies and via impedance measurements at different distances from a surface. The bias modulated response is readily understood via a simple equivalent circuit model. Bias modulated (BM)-SICM is compared to conventional SICM imaging through measurements of substrates with distinct topographical features and yields equivalent results. Finally, BM-SICM with both amplitude and phase feedback is used for topographical imaging of subtle etch features in a calcite crystal surface. The 2 modes yield similar results, but phase-detection opens up the prospect of faster imaging.

  5. Backstepping Strategy for Induction Motor Control

    DEFF Research Database (Denmark)

    Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

    2000-01-01

    Using backstepping, which is a recursive nonlinear design method, a novel approach to control of induction motors is developed. The resulting scheme leads to a nonlinear controller for the torque and the amplitude of the field. A combination of nonlinear damping and observer backstepping with a s......Using backstepping, which is a recursive nonlinear design method, a novel approach to control of induction motors is developed. The resulting scheme leads to a nonlinear controller for the torque and the amplitude of the field. A combination of nonlinear damping and observer backstepping...

  6. Controlling beam halo-chaos via backstepping design

    Institute of Scientific and Technical Information of China (English)

    Gao Yuan; Kong Feng

    2008-01-01

    A backstepping control method is proposed for controlling beam halo-chaos in the periodic focusing channels PFCs) of high-current ion accelerator. The analysis and numerical results show that the method, via adjusting an exterior magnetic field, is effective to control beam halo chaos with five types of initial distribution ion beams, all statistical quantities of the beam halo-chaos are largely reduced, and the uniformity of ion beam is improved. This control method has an important value of application, for the exterior magnetic field can be easily adjusted in the periodical magnetic focusing channels in experiment.

  7. Graphitization of polymer surfaces by scanning ion irradiation

    International Nuclear Information System (INIS)

    Graphitization of polymer surfaces was performed by low-energy Ar+ and He+ ion irradiation. A method of scanning irradiation was implemented. It was found that by scanning ion irradiation, a significantly higher electrical conductivity in the graphitized layers can be achieved in comparison with a conventional broad-beam irradiation. The enhancement of the conductance becomes more pronounced for narrower and better collimated ion beams. In order to analyze these results in more detail, the temperature dependence of conductance of the irradiated samples was investigated. The results of measurements are discussed in terms of weak localization corrections to conductance in disordered metals. The observed effects can be explained by enlargement of graphitic patches, which was achieved with the scanning ion irradiation method.

  8. An automated scanning ion microbeam system

    Science.gov (United States)

    Requicha Ferreira, L. F.; Calvert, J. M.

    A standard Russian quadruplet lens system providing a microbeam on a 6 MV Van de Graaff accelerator has been fitted with an automated scanner. Samples housed in a special target chamber can be positioned accurately in two dimensions with respect to the beam. This is achieved by stepping motors. Two pairs of deflection coils provide electromagnetic deflection of the beam in two dimensions and the combination of electrical deflection of the beam and mechanical displacement of the sample permits scanning over a sample area of 10 mm × 10 mm. A staircase current waveform is provided to the coils and data accumulated at each step is routed appropriately to addresses in a large multichannel analyser (computer). The target chamber accommodates particle and X-ray detectors. The electronic operation is controlled by a microprocessor. The requirements of a complete scan are entered through the keyboard and the complete operation including writing of spectral data onto magnetic tape follows automatically. The arrangement has been used to study details of the oxidation behaviour of iron-chromium alloys as part of a larger programme of oxidation studies centred round the 18O(p, α) 15N reaction.

  9. An automated scanning ion microbeam system

    International Nuclear Information System (INIS)

    A standard Russian quadruplet lens system providing a microbeam on a 6 MV Van de Graaff accelerator has been fitted with an automated scanner. Samples housed in a special target chamber can be positioned accurately in two dimensions with respect to the beam. This is achieved by stepping motors. Two pairs of deflection coils provide electromagnetic deflection of the beam in two dimensions and the combination of electrical deflection of the beam and mechanical displacement of the sample permits scanning over a sample area of 10 mm x 10 mm. A staircase current waveform is provided to the coils and data accumulated at each step is routed appropriately to addresses in a large multichannel analyser (computer). The target chamber accommodates particle and X-ray detectors. The electronic operation is controlled by a microprocessor. The requirements of a complete scan are entered through the keyboard and the complete operation including writing of spectral data onto magnetic tape follows automatically. The arrangement has been used to study details of the oxidation behaviour of iron-chromium alloys as part of a larger programme of oxidation studies centred round the 18O (p,α)15 N reaction. (orig.)

  10. Scanning microbeam using a liquid metal ion source

    Energy Technology Data Exchange (ETDEWEB)

    Ishitani, T.; Tamura, H.; Todokoro, H.

    1982-01-01

    A scanning ion microprobe system using a liquid-Ga ion source and a voltage-asymmetric three-electrode lens is developed. It produces 2--20 keV Ga/sup +/ beams of 0.1--5 ..mu..m diameter with 20 pA--8 nA current. Beam sizes are directly measured by a combined sharp-edge and Faraday cup mehtod. This optical system is well suited for variable energy microprobe applications.

  11. Scanning MOKE investigation of ion-beam-synthesized silicide films

    Energy Technology Data Exchange (ETDEWEB)

    Gumarov, G.G., E-mail: ifoggg@gmail.com [Zavoisky Physical-Technical Institute of THE RAS, 10/7 Sibirsky Trakt, Kazan 420029, Tatarstan (Russian Federation); Kazan Federal University, 18 Kremlyovskaya St., Kazan 420008, Tatarstan (Russian Federation); Konovalov, D.A.; Alekseev, A.V. [Zavoisky Physical-Technical Institute of THE RAS, 10/7 Sibirsky Trakt, Kazan 420029, Tatarstan (Russian Federation); Petukhov, V.Yu. [Zavoisky Physical-Technical Institute of THE RAS, 10/7 Sibirsky Trakt, Kazan 420029, Tatarstan (Russian Federation); Kazan Federal University, 18 Kremlyovskaya St., Kazan 420008, Tatarstan (Russian Federation); Zhikharev, V.A. [Kazan State Technology University, 68 Karl Marx St., Kazan 420015, Tatarstan (Russian Federation); Nuzhdin, V.I.; Shustov, V.A. [Zavoisky Physical-Technical Institute of THE RAS, 10/7 Sibirsky Trakt, Kazan 420029, Tatarstan (Russian Federation)

    2012-07-01

    Fe ions with an energy of 40 keV were implanted into Si plates with the fluence varying in the range of (1.6-3.0) Multiplication-Sign 10{sup 17} ion/cm{sup 2} in the external magnetic field. Scanning magnetooptical Kerr effect (MOKE) studies have shown that all samples possess uniaxial anisotropy. Both the coercive field and the anisotropy field increase with fluence. It was suggested that induced anisotropy is caused by inverse magnetostriction.

  12. Frequency-scanning marginal oscillator for ion cyclotron resonance spectroscopy

    Science.gov (United States)

    Kemper, Paul R.; Bowers, Michael T.

    1982-07-01

    A number of ion cyclotron resonance applications have arisen in the past few years which require a frequency-scanned detection system. Since the traditional marginal oscillator detector has always been a fixed-frequency detector, alternative detection techniques such as bridge circuit detectors have become widely used. In this paper we present an alternative to the bridge detector, namely, a frequency-scanning marginal oscillator. Requirements and modifications necessary to convert a marginal oscillator to frequency scanning operation are discussed in detail and the necessary circuit diagrams presented. Finally, a theoretical comparison is made between bridge circuit and marginal oscillator sensitivities.

  13. Backstepping Strategy for Induction Motor Control

    DEFF Research Database (Denmark)

    Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

    2000-01-01

    Using backstepping, which is a recursive nonlinear design method, a novel approach to control of induction motors is developed. The resulting scheme leads to a nonlinear controller for the torque and the amplitude of the field. A combination of nonlinear damping and observer backstepping...... with a simple flux observer is used in the design. Assuming known motor parameters the design achieves stability with guaranteed region of attraction. It is also shown how a conventional field oriented controller may be obtained by omitting parts of the nonlinear controller....

  14. Simulating imaging with the scanning ion-conductance microscope.

    Science.gov (United States)

    Adenle, Omolabake; Fitzgerald, William

    2005-01-01

    The Scanning Ion-Conductance Microscope (SICM) is a member of the family of Scanned Probe Microscopes (SPM). Examples include the Scanning Electrochemical Microscope (SECM) and Atomic Force Microscope (AFM). SICM uses the ion-concentration field at the tip of a micropipette filled with an electrolyte solution as a probe to generate images of sample topography. As with other members of the SPM family, the probe geometry determines the observed image. This paper presents mathematical models for simulating the SICM in its different operating modes with the intent of creating a framework within which the effect of probe-geometry can be studied. We validate our model by comparing simulated approach-curves with empirical data. Finally, we show simulated images of a Gaussian-bump substrate under the different operating modes of the SICM. PMID:17280955

  15. Scanning ion deep level transient spectroscopy: I. Theory

    International Nuclear Information System (INIS)

    Theoretical aspects of a new technique for the MeV ion microbeam are described in detail for the first time. The basis of the technique, termed scanning ion deep level transient spectroscopy (SIDLTS), is the imaging of defect distributions within semiconductor devices. The principles of SIDLTS are similar to those behind other deep level transient spectroscopy (DLTS) techniques with the main difference stemming from the injection of carriers into traps using the localized energy-loss of a focused MeV ion beam. Energy-loss of an MeV ion generates an electron-hole pair plasma, providing the equivalent of a DLTS trap filling pulse with a duration which depends on space-charge screening of the applied electric field and ambipolar erosion of the plasma for short ranging ions. Some nanoseconds later, the detrapping current transient is monitored as a charge transient. Scanning the beam in conjunction with transient analysis allows the imaging of defect levels. As with DLTS, the temperature dependence of the transient can be used to extract trap activation levels. In this, the first of a two-part paper, we introduce the various stages of corner capture and derive a simple expression for the observed charge transient. The second paper will illustrate the technique on a MeV ion implanted Au-Si Schottky junction

  16. Phase modulation mode of scanning ion conductance microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Peng; Zhang, Changlin [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Liu, Lianqing, E-mail: lqliu@sia.cn, E-mail: gli@engr.pitt.edu; Wang, Yuechao; Yang, Yang [State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016 (China); Li, Guangyong, E-mail: lqliu@sia.cn, E-mail: gli@engr.pitt.edu [Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 (United States)

    2014-08-04

    This Letter reports a phase modulation (PM) mode of scanning ion conductance microscopy. In this mode, an AC current is directly generated by an AC voltage between the electrodes. The portion of the AC current in phase with the AC voltage, which is the current through the resistance path, is modulated by the tip-sample distance. It can be used as the input of feedback control to drive the scanner in Z direction. The PM mode, taking the advantages of both DC mode and traditional AC mode, is less prone to electronic noise and DC drift but maintains high scanning speed. The effectiveness of the PM mode has been proven by experiments.

  17. Nanochannel alignment analysis by scanning transmission ion microscopy

    DEFF Research Database (Denmark)

    Rajta, I.; Gál, G.A.B.; Szilasi, S.Z.;

    2010-01-01

    thickness, had pore diameters of ∼ 215nm and spacing of ∼ 450nm. When the proton beam size was limited to a single domain, a peak transmission ratio of 19% was observed as is expected from the geometry (∼19-20%). This result points out an almost perfectly parallel alignment of the capillaries within one...... domain. However, for larger beam scanning areas (sampling multiple domains) the transmission ratio was reduced to 5%. The STIM analysis over an area larger than the typical domain size revealed an overall capillary angular spread of ∼ 2°. © 2010 IOP Publishing Ltd.......In this paper a study on the ion transmission ratio of a nanoporous alumina sample is presented. The sample was investigated by scanning transmission ion microscopy (STIM) with different beam sizes. The hexagonally close-packed AlO nanocapillary array, realized as a suspended membrane of 15 νm...

  18. Design New Intelligent PID like Fuzzy Backstepping Controller

    OpenAIRE

    Arzhang Khajeh; Farzin Piltan; Mohammad Reza Rashidian; Afsaneh Salehi; Ehsan pouladi

    2014-01-01

    The minimum rule base Proportional Integral Derivative (PID) Fuzzy backstepping Controller is presented in this research. The popularity of PID Fuzzy backstepping controller can be attributed to their robust performance in a wide range of operating conditions and partly to their functional simplicity. The process of setting of PID Fuzzy backstepping controller can be determined as an optimization task. Over the years, use of intelligent strategies for tuning of these controllers has been grow...

  19. Double micropipettes configuration method of scanning ion conductance microscopy

    Science.gov (United States)

    Zhuang, Jian; Li, Zeqing; Jiao, Yangbohan

    2016-07-01

    In this paper, a new double micropipettes configuration mode of scanning ion conductance microscopy (SICM) is presented to better overcome ionic current drift and further improve the performance of SICM, which is based on a balance bridge circuit. The article verifies the feasibility of this new configuration mode from theoretical and experimental analyses, respectively, and compares the quality of scanning images in the conventional single micropipette configuration mode and the new double micropipettes configuration mode. The experimental results show that the double micropipettes configuration mode of SICM has better effect on restraining ionic current drift and better performance of imaging. Therefore, this article not only proposes a new direction of overcoming the ionic current drift but also develops a new method of SICM stable imaging.

  20. A computer program for scanning transmission ion microscopy simulation

    Science.gov (United States)

    Wu, R.; Shen, H.; Mi, Y.; Sun, M. D.; Yang, M. J.

    2005-04-01

    With the installation of the Scanning Proton Microprobe system at Fudan University, we are in the process of developing a three-dimension reconstruction technique based on scanning transmission ion microscopy-computed tomography (STIM-CT). As the first step, a related computer program of STIM simulation has been established. This program is written in the Visual C++®, using the technique of OOP (Object Oriented Programming) and it is a standard multiple-document Windows® program. It can be run with all MS Windows® operating systems. The operating mode is the menu mode, using a multiple process technique. The stopping power theory is based on the Bethe-Bloch formula. In order to simplify the calculation, the improved cylindrical coordinate model was introduced in the program instead of a usual spherical or cylindrical coordinate model. The simulated results of a sample at several rotation angles are presented.

  1. High resolution helium ion scanning microscopy of the rat kidney.

    Directory of Open Access Journals (Sweden)

    William L Rice

    Full Text Available Helium ion scanning microscopy is a novel imaging technology with the potential to provide sub-nanometer resolution images of uncoated biological tissues. So far, however, it has been used mainly in materials science applications. Here, we took advantage of helium ion microscopy to explore the epithelium of the rat kidney with unsurpassed image quality and detail. In addition, we evaluated different tissue preparation methods for their ability to preserve tissue architecture. We found that high contrast, high resolution imaging of the renal tubule surface is possible with a relatively simple processing procedure that consists of transcardial perfusion with aldehyde fixatives, vibratome tissue sectioning, tissue dehydration with graded methanol solutions and careful critical point drying. Coupled with the helium ion system, fine details such as membrane texture and membranous nanoprojections on the glomerular podocytes were visualized, and pores within the filtration slit diaphragm could be seen in much greater detail than in previous scanning EM studies. In the collecting duct, the extensive and striking apical microplicae of the intercalated cells were imaged without the shrunken or distorted appearance that is typical with conventional sample processing and scanning electron microscopy. Membrane depressions visible on principal cells suggest possible endo- or exocytotic events, and central cilia on these cells were imaged with remarkable preservation and clarity. We also demonstrate the use of colloidal gold probes for highlighting specific cell-surface proteins and find that 15 nm gold labels are practical and easily distinguishable, indicating that external labels of various sizes can be used to detect multiple targets in the same tissue. We conclude that this technology represents a technical breakthrough in imaging the topographical ultrastructure of animal tissues. Its use in future studies should allow the study of fine cellular details

  2. Semiconductor characterization by scanning ion beam induced charge (IBIC) microscopy

    CERN Document Server

    Vittone, E; Olivero, P; Manfredotti, C; Jaksic, M; Giudice, A Lo; Fizzotti, F; Colombo, E

    2016-01-01

    The acronym IBIC (Ion Beam Induced Charge) was coined in early 1990's to indicate a scanning microscopy technique which uses MeV ion beams as probes to image the basic electronic properties of semiconductor materials and devices. Since then, IBIC has become a widespread analytical technique to characterize materials for electronics or for radiation detection, as testified by more than 200 papers published so far in peer-reviewed journals. Its success stems from the valuable information IBIC can provide on charge transport phenomena occurring in finished devices, not easily obtainable by other analytical techniques. However, IBIC analysis requires a robust theoretical background to correctly interpret experimental data. In order to illustrate the importance of using a rigorous mathematical formalism, we present in this paper a benchmark IBIC experiment aimed to test the validity of the interpretative model based on the Gunn's theorem and to provide an example of the analytical capability of IBIC to characteriz...

  3. Amplitude Modulation Mode of Scanning Ion Conductance Microscopy.

    Science.gov (United States)

    Li, Peng; Liu, Lianqing; Yang, Yang; Zhou, Lei; Wang, Dong; Wang, Yuechao; Li, Guangyong

    2015-08-01

    Live-cell imaging at the nanoscale resolution is a hot research topic in the field of life sciences for the direct observation of cellular biological activity. Scanning ion conductance microscopy (SICM) is one of the few effective imaging tools for live-cell imaging at the nanoscale resolution. However, there are various problems in existing scanning modes. The hopping and AC modes suffer from low speed, whereas the DC mode is prone to instability because of the DC drift and external electrical interference. In this article, we propose an amplitude modulation (AM) mode of SICM, which employs an AC voltage to enhance the stability and improve the scanning speed. In this AM mode, we introduce a capacitance compensation method to eliminate capacitance effect and use the amplitude of the AC current component to control the tip movement. Experimental results on polydimethylsiloxane samples verify the validity of the AM mode and demonstrate an improved performance of both speed and stability of this new mode. PMID:25759185

  4. Scanning electrochemical microscopy of Li-ion batteries.

    Science.gov (United States)

    Ventosa, E; Schuhmann, W

    2015-11-21

    Li-ion batteries (LIBs) are receiving increasing attention over the past decade due to their high energy density. This energy storage technology is expected to continue improving the performance, especially for its large-scale deployment in plug-in hybrid electric vehicles (PHEVs) and full electric vehicles (EVs). Such improvement requires having a large variety of analytical techniques at scientists' disposal in order to understand and address the multiple mechanisms and processes occurring simultaneously in this complex system. This perspective article aims to highlight the strength and potential of scanning electrochemical microscopy (SECM) in this field. After a brief description of a LIB system and the most commonly used techniques in this field, the unique information provided by SECM is illustrated by discussing several recent examples from the literature. PMID:26076998

  5. Multiswitching Synchronization of a Driven Hyperchaotic Circuit Using Active Backstepping

    Directory of Open Access Journals (Sweden)

    A. Ayotunde Ajayi

    2014-01-01

    Full Text Available An active backstepping technique is proposed for the realization of multiswitching synchronization of periodically forced hyperchaotic Van der Pol-Duffing oscillators. The active backstepping technique is a systematic design approach with recursive procedures that skillfully optimizes the choice of Lyapunov functions and active control technique. Using the active backstepping technique, the usual master-slave synchronization scheme is extended to study the synchronization of systems with different combinations of the slave states variables with master state variables. Our numerical results confirm the effectiveness of the proposed analytical technique.

  6. Single ion impact detection and scanning probe aligned ion implantation for quantum bit formation

    Energy Technology Data Exchange (ETDEWEB)

    Weis, Christoph D.

    2011-10-04

    Quantum computing and quantum information processing is a promising path to replace classical information processing via conventional computers which are approaching fundamental physical limits. Instead of classical bits, quantum bits (qubits) are utilized for computing operations. Due to quantum mechanical phenomena such as superposition and entanglement, a completely different way of information processing is achieved, enabling enhanced performance for certain problem sets. Various proposals exist on how to realize a quantum bit. Among them are electron or nuclear spins of defect centers in solid state systems. Two such candidates with spin degree of freedom are single donor atoms in silicon and nitrogen vacancy (NV) defect centers in diamond. Both qubit candidates possess extraordinary qualities which makes them promising building blocks. Besides certain advantages, the qubits share the necessity to be placed precisely in their host materials and device structures. A commonly used method is to introduce the donor atoms into the substrate materials via ion implantation. For this, focused ion beam systems can be used, or collimation techniques as in this work. A broad ion beam hits the back of a scanning probe microscope (SPM) cantilever with incorporated apertures. The high resolution imaging capabilities of the SPM allows the non destructive location of device areas and the alignment of the cantilever and thus collimated ion beam spot to the desired implant locations. In this work, this technique is explored, applied and pushed forward to meet necessary precision requirements. The alignment of the ion beam to surface features, which are sensitive to ion impacts and thus act as detectors, is demonstrated. The technique is also used to create NV center arrays in diamond substrates. Further, single ion impacts into silicon device structures are detected which enables deliberate single ion doping.

  7. Single ion impact detection and scanning probe aligned ion implantation for quantum bit formation

    International Nuclear Information System (INIS)

    Quantum computing and quantum information processing is a promising path to replace classical information processing via conventional computers which are approaching fundamental physical limits. Instead of classical bits, quantum bits (qubits) are utilized for computing operations. Due to quantum mechanical phenomena such as superposition and entanglement, a completely different way of information processing is achieved, enabling enhanced performance for certain problem sets. Various proposals exist on how to realize a quantum bit. Among them are electron or nuclear spins of defect centers in solid state systems. Two such candidates with spin degree of freedom are single donor atoms in silicon and nitrogen vacancy (NV) defect centers in diamond. Both qubit candidates possess extraordinary qualities which makes them promising building blocks. Besides certain advantages, the qubits share the necessity to be placed precisely in their host materials and device structures. A commonly used method is to introduce the donor atoms into the substrate materials via ion implantation. For this, focused ion beam systems can be used, or collimation techniques as in this work. A broad ion beam hits the back of a scanning probe microscope (SPM) cantilever with incorporated apertures. The high resolution imaging capabilities of the SPM allows the non destructive location of device areas and the alignment of the cantilever and thus collimated ion beam spot to the desired implant locations. In this work, this technique is explored, applied and pushed forward to meet necessary precision requirements. The alignment of the ion beam to surface features, which are sensitive to ion impacts and thus act as detectors, is demonstrated. The technique is also used to create NV center arrays in diamond substrates. Further, single ion impacts into silicon device structures are detected which enables deliberate single ion doping.

  8. Scanning deep level transient spectroscopy using an MeV ion microprobe

    Energy Technology Data Exchange (ETDEWEB)

    Laird, J.S.; Bardos, R.A.; Saint, A.; Moloney, G.M.; Legge, G.F.J. [Melbourne Univ., Parkville, VIC (Australia)

    1993-12-31

    Traditionally the scanning ion microprobe has given little or no information regarding the electronic structure of materials in particular semiconductors. A new imaging technique called Scanning Ion Deep Level Transient Spectroscopy (SIDLTS) is presented which is able to spatially map alterations in the band gap structure of materials by lattice defects or impurities. 3 refs., 2 figs.

  9. Ancient Pb and Ti mobilization revealed by Scanning Ion Imaging

    Science.gov (United States)

    Kusiak, Monika A.; Whitehouse, Martin J.; Wilde, Simon A.

    2014-05-01

    Zircons from strongly layered early Archean ortho- and paragneisses in ultra-high temperature (UHT) metamorphic rocks of the Napier Complex, Enderby Land, East Antarctica are characterized by complex U-Th-Pb systematics [1,2,3]. A large number of zircons from three samples, Gage Ridge, Mount Sones and Dallwitz Nunatak, are reversely discordant (U/Pb ages older than 207Pb/206Pb ages) with the oldest date of 3.9 Ga [4] (for the grain from Gage Ridge orthogneiss). To further investigate this process, we utilized a novel high spatial resolution Scanning Ion Imaging technique on the CAMECA IMS 1280 at the Natural History Museum in Stockholm. Areas of 70 μm x 70 μm were selected for imaging in mono- and multicollection modes using a ~2 μm rastered primary beam to map out the distribution of 48Ti, 89Y, 180Hf, 232Th, 238U, 204Pb, 206Pb and 207Pb. The ion maps reveal variable distribution of certain elements within analysed grains that can be compared to their CL response. Yttrium, together with U and Th, exhibits zonation visible on the CL images, Hf shows expected minimal variation. Unusual patchiness is visible in the map for Ti and Pb distribution. The bright patches with enhanced signal do not correspond to any zones or to crystal imperfections (e.g. cracks). The presence of patchy titanium is likely to affect Ti-in-zircon thermometry, and patchy Pb affecting 207Pb/206Pb ages, usually considered as more robust for Archean zircons. Using the WinImage program, we produced 207Pb/206Pb ratio maps that allow calculation of 207Pb/206Pb ages for spots of any size within the frame of the picture and at any time after data collection. This provides a new and unique method for obtaining age information from zircon. These maps show areas of enhanced brightness where the 207Pb/206Pb ratio is higher and demonstrate that within these small areas (μm scale) the apparent 207Pb/206Pb age is older, in some of these patches even > 4 Ga. These data are a result of ancient Pb

  10. Design New Intelligent PID like Fuzzy Backstepping Controller

    Directory of Open Access Journals (Sweden)

    Arzhang Khajeh

    2014-02-01

    Full Text Available The minimum rule base Proportional Integral Derivative (PID Fuzzy backstepping Controller is presented in this research. The popularity of PID Fuzzy backstepping controller can be attributed to their robust performance in a wide range of operating conditions and partly to their functional simplicity. The process of setting of PID Fuzzy backstepping controller can be determined as an optimization task. Over the years, use of intelligent strategies for tuning of these controllers has been growing. PID methodology has three inputs and if any input is described with seven linguistic values, and any rule has three conditions we will need 7 × 7 × 7 = 343 rules. It is too much work to write 343 rules. In this research the PID-like fuzzy controller can be constructed as a parallel structure of a PD-like fuzzy controller and a PI-like controller to have the minimum rule base. However backstepping controller is work based on cancelling decoupling and nonlinear terms of dynamic parameters of each link, this controller is work based on manipulator dynamic model and this technique is highly sensitive to the knowledge of all parameters of nonlinear robot manipulator’s dynamic equation. This research is used to reduce or eliminate the backstepping controller problem based on minimum rule base fuzzy logic theory to control of flexible robot manipulator system and testing of the quality of process control in the simulation environment of MATLAB/SIMULINK Simulator.

  11. Scanning ion deep level transient spectroscopy: II. Ion irradiated Au-Si Schottky junctions

    International Nuclear Information System (INIS)

    Here we introduce a new technique called scanning ion deep level transient spectroscopy (SIDLTS) for the spatial analysis of electrically active defects in devices. In the first part of this paper, a simple theory behind SIDLTS was introduced and factors determining its sensitivity and resolution were discussed. In this paper, we demonstrate the technique on MeV boron implantation induced defects in an Au-Si Schottky junction. SIDLTS measurements are compared with capacitance DLTS measurements over the temperature range, 100-300 K. SIDLTS analyses indicate the presence of two levels, one of which was positively identified as the Ec - 0.23 eV divacancy level. The high sensitivity of SIDLTS is verified and the advantages and limitations of the technique are discussed in light of non-exponential components in the charge transient response. Reasons for several undetected levels are also discussed

  12. Backstepping Controller for Electrically Driven Flexible Joint Manipulator Under Uncertainties

    Directory of Open Access Journals (Sweden)

    Lilia Zouari

    2014-12-01

    Full Text Available The grown complexity of the robot manipulators dynamics taking into account the jointflexibility, parameter uncertainties and unknown bounded disturbances makes conventionalcontrol strategies difficult and complex to synthesize. This paper focuses on the investiga-tion into backstepping control of flexible joint manipulator driving by Brushless DC Motor(BDCM in the presence of parameter uncertainties and unknown bounded disturbances fortracking trajectory. The goal of this paper is to compensate all uncertainties and distur-bances for flexible joint manipulator. To study the effectiveness of the controllers, backstep-ping controller has been developed for position control and an hysteresis controller has beentreated for current control. Simulation results of the response of the flexible joint manipu-lators associated with their controllers have been presented. The high performances of thebackstepping control are examined in terms of tracking accuracy and error reduction.

  13. How occasional backstepping can speed up a processive motor protein

    CERN Document Server

    Bier, M

    2008-01-01

    Fueled by the hydrolysis of ATP, the motor protein kinesin literally walks on two legs along the biopolymer microtubule. The number of accidental backsteps that kinesin takes appears to be much larger than what one would expect given the amount of free energy that ATP hydrolysis makes available. This is puzzling as more than a billion years of natural selection should have optimized the motor protein for its speed and efficiency. But more backstepping allows for the production of more entropy. Such entropy production will make free energy available. With this additional free energy, the catalytic cycle of the kinesin can be speeded up. We show how measured backstep percentages represent an optimum at which maximal net forward speed is achieved.

  14. 3D Imaging of mammalian cells with ion-abrasion scanning electron microscopy

    OpenAIRE

    Heymann, Jurgen A. W.; Shi, Dan; Kim, Sang; Bliss, Donald; Milne, Jacqueline L. S.; Subramaniam, Sriram

    2008-01-01

    Understanding the hierarchical organization of molecules and organelles within the interior of large eukaryotic cells is a challenge of fundamental interest in cell biology. We are using ion-abrasion scanning electron microscopy (IA-SEM) to visualize this hierarchical organization in an approach that combines focused ion-beam milling with scanning electron microscopy. Here, we extend our previous studies on imaging yeast cells to image subcellular architecture in human melanoma cells and mela...

  15. Experimental Characterization of Secular Frequency Scanning in Ion Trap Mass Spectrometers

    Science.gov (United States)

    Snyder, Dalton T.; Pulliam, Christopher J.; Wiley, Joshua S.; Duncan, Jason; Cooks, R. Graham

    2016-07-01

    Secular frequency scanning is implemented and characterized using both a benchtop linear ion trap and a miniature rectilinear ion trap mass spectrometer. Separation of tetraalkylammonium ions and those from a mass calibration mixture and from a pesticide mixture is demonstrated with peak widths approaching unit resolution for optimized conditions using the benchtop ion trap. The effects on the spectra of ion trap operating parameters, including waveform amplitude, scan direction, scan rate, and pressure are explored, and peaks at black holes corresponding to nonlinear (higher-order field) resonance points are investigated. Reverse frequency sweeps (increasing mass) on the Mini 12 are shown to result in significantly higher ion ejection efficiency and superior resolution than forward frequency sweeps that decrement mass. This result is accounted for by the asymmetry in ion energy absorption profiles as a function of AC frequency and the shift in ion secular frequency at higher amplitudes in the trap due to higher order fields. We also found that use of higher AC amplitudes in forward frequency sweeps biases ions toward ejection at points of higher order parametric resonance, despite using only dipolar excitation. Higher AC amplitudes also increase peak width and decrease sensitivity in both forward and reverse frequency sweeps. Higher sensitivity and resolution were obtained at higher trap pressures in the secular frequency scan, in contrast to conventional resonance ejection scans, which showed the opposite trend in resolution on the Mini 12. Mass range is shown to be naturally extended in secular frequency scanning when ejecting ions by sweeping the AC waveform through low frequencies, a method which is similar, but arguably superior, to the more usual method of mass range extension using low q resonance ejection.

  16. High resolution imaging using scanning ion conductance microscopy with improved distance feedback control

    Institute of Scientific and Technical Information of China (English)

    Chao Li; Nicholas Johnson; Victor Ostanin; Andrew Shevchuk; Liming Ying; Yuri Korchev; David Klenerman

    2008-01-01

    Microscopy is an essential technique for observation on living cells. There is currently great interest in applying scanning probe microscopy to image-living biological cells in their natural environment at the nanometer scale. Scanning ion conductance microscopy is a new form of scanning probe microscopy, which enables non-contact high-resolution imaging of living biological cells. Based on a scanned nanopipette in physiological buffer, the distance feedback control uses the ion current to control the distance between the pipette tip and the sample surface. However, this feedback control has difficulties over slopes on convoluted cell surfaces, which limits its resolution. In this study, we present an improved form of feedback control that removes the contribution of up to the third-order slope from the ion current signal, hence providing a more accurate signal for controlling the distance. We show that this allows faster and lower noise topographic high-resolution imaging.

  17. Depth scanning for a conformal ion beam treatment of deep seated tumours

    International Nuclear Information System (INIS)

    Only target-conformal treatment allows one to exploit the advantages of ion beams (the increased dose and high biological efficiency at the end of the particle range) to a maximum extent. Up to now, target-conformal treatments such as spot scanning or intensity-controlled raster scanning have used fast magnetic lateral deflection in one or two directions perpendicular to the beam axis and a slow range variation in the longitudinal axis by active or passive energy variation. The present paper describes a new method for conformal irradiation with a fast intensity-controlled longitudinal scan in the beam direction, called 'depth scanning'. Its advantages and disadvantages will be discussed. First experimental results from depth scanning will be presented. Only target-conformal treatment allows one to exploit the advantages of ion beams (the increased dose and high biological efficiency at the end of the particle range) to a maximum extent. Up to now, target-conformal treatments such as spot scanning or intensity-controlled raster scanning have used fast magnetic lateral deflection in one or two directions perpendicular to the beam axis and a slow range variation in the longitudinal axis by active or passive energy variation. The present paper describes a new method for conformal irradiation with a fast intensity-controlled longitudinal scan in the beam direction, called 'depth scanning'. Its advantages and disadvantages will be discussed. First experimental results from depth scanning will be presented. (author)

  18. Nonlinear Superheat Control of a Refrigeration Plant using Backstepping

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    2008-01-01

    This paper proposes a novel method for superheat and capacity control of refrigeration systems. The main idea is to control the superheat by the compressor speed and capacity by the refrigerant flow. A new low order nonlinear model of the evaporator is developed and used in a backstepping design...

  19. Integrator backstepping using contraction theory: a brief technological note

    DEFF Research Database (Denmark)

    Jouffroy, Jerome; Lottin, Jacques

    While the use of Lyapunov function candidates for integrator backstepping has been extensively studied in the literature, little research has been conducted regarding the applicability of the so-called incremental stability approaches. This note addresses the problem of the use of an incremental ...

  20. Observer Backstepping Control for Variable Speed Wind Turbine

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Gryning, Mikkel Peter Sidoroff; Blanke, Mogens

    2013-01-01

    This paper presents an observer backstepping controller as feasible solution to variable speed control of wind turbines to maximize wind power capture when operating between cut-in and rated wind speeds. The wind turbine is modeled as a two-mass drive-train system controlled by the generator torq...

  1. Dark-Field Scanning Transmission Ion Microscopy via Detection of Forward-Scattered Helium Ions with a Microchannel Plate.

    Science.gov (United States)

    Woehl, Taylor J; White, Ryan M; Keller, Robert R

    2016-06-01

    A microchannel plate was used as an ion sensitive detector in a commercial helium ion microscope (HIM) for dark-field transmission imaging of nanomaterials, i.e. scanning transmission ion microscopy (STIM). In contrast to previous transmission HIM approaches that used secondary electron conversion holders, our new approach detects forward-scattered helium ions on a dedicated annular shaped ion sensitive detector. Minimum collection angles between 125 mrad and 325 mrad were obtained by varying the distance of the sample from the microchannel plate detector during imaging. Monte Carlo simulations were used to predict detector angular ranges at which dark-field images with atomic number contrast could be obtained. We demonstrate atomic number contrast imaging via scanning transmission ion imaging of silica-coated gold nanoparticles and magnetite nanoparticles. Although the resolution of STIM is known to be degraded by beam broadening in the substrate, we imaged magnetite nanoparticles with high contrast on a relatively thick silicon nitride substrate. We expect this new approach to annular dark-field STIM will open avenues for more quantitative ion imaging techniques and advance fundamental understanding of underlying ion scattering mechanisms leading to image formation. PMID:27153003

  2. Dark-Field Scanning Transmission Ion Microscopy via Detection of Forward-Scattered Helium Ions with a Microchannel Plate.

    Science.gov (United States)

    Woehl, Taylor J; White, Ryan M; Keller, Robert R

    2016-06-01

    A microchannel plate was used as an ion sensitive detector in a commercial helium ion microscope (HIM) for dark-field transmission imaging of nanomaterials, i.e. scanning transmission ion microscopy (STIM). In contrast to previous transmission HIM approaches that used secondary electron conversion holders, our new approach detects forward-scattered helium ions on a dedicated annular shaped ion sensitive detector. Minimum collection angles between 125 mrad and 325 mrad were obtained by varying the distance of the sample from the microchannel plate detector during imaging. Monte Carlo simulations were used to predict detector angular ranges at which dark-field images with atomic number contrast could be obtained. We demonstrate atomic number contrast imaging via scanning transmission ion imaging of silica-coated gold nanoparticles and magnetite nanoparticles. Although the resolution of STIM is known to be degraded by beam broadening in the substrate, we imaged magnetite nanoparticles with high contrast on a relatively thick silicon nitride substrate. We expect this new approach to annular dark-field STIM will open avenues for more quantitative ion imaging techniques and advance fundamental understanding of underlying ion scattering mechanisms leading to image formation.

  3. A Coefficient Diagram Method Controller with Backstepping Methodology for Robotic Manipulators

    Science.gov (United States)

    Haouari, Fouad; Nourdine, Bali; Boucherit, Mohamed Segir; Tadjine, Mohamed

    2015-09-01

    A new robust control procedure for robot manipulators is proposed in this paper. Coefficients diagram method controllers CDM and Backstepping methodology are combined to create the novel control law. Two steps of backstepping on the resulting system are used to design a nonlinear CDM-Backstepping controller. Simulations on a PUMA robot including external disturbances, parametric uncertainties and noises are performed to show the effectiveness and feasibility of the proposed method.

  4. Optimisation of the ion optical range adaptation method for tracking of moving tumours with scanned ion beams

    International Nuclear Information System (INIS)

    Currently an ion optical solution for beam tracking of moving targets with scanned ion beams is being investigated at GSI for the treatment of moving tumours, such as lung cancer. Beam tracking compensates target motion by adapting the lateral beam position as well as the beam range according to the motion parameters. Tracking of the lateral position is achieved via scanning magnets. For range adaptation the proposed ion optical solution uses an energy degrader with variable thickness inserted into the therapy beam line downstream of the synchrotron. By deflecting the particle beam via dipole magnets to different positions on the degrader, the range of the Bragg peak can be adjusted in real-time. Hence density changes due to organ motion can be compensated for each target spot during beam scanning. In order to reach a beam quality suitable for therapy with this method, systematic studies on the ion optical parameters have to be carried out. Different degrader designs (ramp or discrete step shaped), different materials (e.g. PMMA, graphite), as well as optimised degrader positions have been examined. The results of simulated beam profiles are presented.

  5. Fuzzy Backstepping Sliding Mode Control for Mismatched Uncertain System

    Directory of Open Access Journals (Sweden)

    H. Q. Hou

    2014-06-01

    Full Text Available Sliding mode controllers have succeeded in many control problems that the conventional control theories have difficulties to deal with; however it is practically impossible to achieve high-speed switching control. Therefore, in this paper an adaptive fuzzy backstepping sliding mode control scheme is derived for mismatched uncertain systems. Firstly fuzzy sliding mode controller is designed using backstepping method based on the Lyapunov function approach, which is capable of handling mismatched problem. Then fuzzy sliding mode controller is designed using T-S fuzzy model method, it can improve the performance of the control systems and their robustness. Finally this method of control is applied to nonlinear system as a case study; simulation results are also provided the performance of the proposed controller.

  6. Focused Ion Beam - Scanning Electron Microscopy Applied to Electrically Insulating Materials

    NARCIS (Netherlands)

    de Winter, D.A.M.

    2015-01-01

    The Focused Ion Beam – Scanning Electron Microscope (FIB-SEM) is a versatile instrument originating from the semiconductor industry. The FIB is used to produce cross sections of pre-defined locations of interest, which are imaged and analyzed with the SEM. Repeated FIB cross sectioning and subsequen

  7. CHAOS SYNCHRONIZATION OF MORSE OSCILLATOR VIA BACKSTEPPING DESIGN

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Synchronization and adaptive synchronization of Morse oscillator with periodic forced section is investigated in this paper. Backstepping design is a recursive procedure that combines the choice of Lyapunov function with the design of controller. The proposed approaches offers a syetematic design procedure for synchronization and adaptive synchronization of a large class of continuous-time chaotic systems in the chaos research literature. Simulation results are presented to show the effectiveness of the ...

  8. Synchronization of spatiotemporal chaos in complex networks via backstepping

    Institute of Scientific and Technical Information of China (English)

    Chai Yuan; Lü Ling; Chen Li-Qun

    2012-01-01

    A backstepping approach is proposed for the synchronization of chain networks of multi-spatiotemporal chaotic systems with topologically equivalent structures.The synchronization of multi-spatiotemporal chaotic systems is implemented by adding the control only to a terminal node,and the controller is designed via a corresponding update law.The control law is applied to spatiotemporal Gray-Scott systems.Numerical results demonstrate the effectiveness and the feasibility of the proposed approach.

  9. Backstepping Designs for Aircraft Control - What is there to Gain?

    OpenAIRE

    Härkegård, Ola

    2001-01-01

    Aircraft flight control design is traditionally based on linear control theory, due to the existing wealth of tools for linear design and analysis. However, in order to achieve tactical advantages, modern fighter aircraft strive towards performing maneuvers outside the region where the dynamics of flight are linear, and the need for nonlinear tools arises. In this paper, backstepping is proposed as a possible framework for nonlinear flight control design. Its capabilities of handling five maj...

  10. Output Feedback M-MRAC Backstepping With Aerospace Applications

    Science.gov (United States)

    Stepanyan, Vahram; Krishnakumar, Kalmanje Sriniva

    2014-01-01

    The paper presents a certainty equivalence output feedback backstepping adaptive control design method for the systems of any relative degree with unmatched uncertainties without over-parametrization. It uses a fast prediction model to estimate the unknown parameters, which is independent of the control design. It is shown that the system's input and output tracking errors can be systematically decreased by the proper choice of the design parameters. The approach is applied to aerospace control problems and tested in numerical simulations.

  11. Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam Milling

    Directory of Open Access Journals (Sweden)

    Takahiro eSonomura

    2013-02-01

    Full Text Available Three-dimensional reconstruction of ultrastructure of rat brain with minimal effort has recently been realized by scanning electron microscopy combined with focused ion beam milling (FIB-SEM. Because application of immunohistochemical staining to electron microscopy has a great advantage in that molecules of interest are specifically localized in ultrastructures, we here tried to apply immunocytochemistry to FIB-SEM and correlate immunoreactivity in confocal laser-scanning microcopy (CF-LSM with that in FIB-SEM. The dendrites of medium-sized spiny neurons in rat neostriatum were visualized with a recombinant viral vector, which labeled the infected neurons with membrane-targeted GFP in a Golgi stain-like fashion, and thalamostriatal afferent terminals were immunolabeled with Cy5 fluorescence for vesicular glutamate transporter 2 (VGluT2. After detecting the sites of terminals apposed to the dendrites in CF-LSM, GFP and VGluT2 immunoreactivities were further developed for electron microscopy by the immunogold/silver enhancement and immunoperoxidase/diaminobenzidine (DAB methods, respectively. In the contrast-inverted FIB-SEM images, silver precipitation and DAB deposits were observed as fine dark grains and diffuse dense profiles, respectively, indicating that these immunoreactivities were easily recognizable as in the images of transmission electron microscopy. In the sites of interest, some appositions were revealed to display synaptic specialization of asymmetric type. The present method is thus useful in the three-dimensional analysis of immunocytochemically differentiated synaptic connection in the central neural circuit.

  12. Development of scanning transmission ion microscopy computed tomography at Fudan Microbeam line

    International Nuclear Information System (INIS)

    The computed tomography was applied to setting STIM (Scanning Transmission Ion Microscopy) projections recorded at the Fudan Ion Beam Laboratory. In this work, in order to visualize the three-dimensional mass density distribution in several specimens, example for a test structure of hollow gold cylinder was presented together with a detailed description of the developed system, including data reconstruction code (Tomorebuild 2) and image display software (AMIRA®). Future development will allow the particle induced X-ray emission tomography for elemental analysis of micrometer-sized samples. (authors)

  13. Dosimetric characterization of a microDiamond detector in clinical scanned carbon ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Marinelli, Marco; Prestopino, G., E-mail: giuseppe.prestopino@uniroma2.it; Verona, C.; Verona-Rinati, G. [INFN—Dipartimento di Ingegneria Industriale, Università di Roma “Tor Vergata,” Via del Politecnico 1, Roma 00133 (Italy); Ciocca, M.; Mirandola, A.; Mairani, A. [Fondazione CNAO, Strada Campeggi 53, Pavia 27100 (Italy); Raffaele, L. [INFN—Laboratori Nazionali del Sud, Via S. Sofia 62, Catania 95123, Italy and Fondazione CNAO, Strada Campeggi 53, Pavia 27100 (Italy); Magro, G. [INFN—Dipartimento di Fisica, Università degli Studi di Pavia, Via U. Bassi 6, Pavia 27100, Italy and Fondazione CNAO, Strada Campeggi 53, Pavia 27100 (Italy)

    2015-04-15

    Purpose: To investigate for the first time the dosimetric properties of a new commercial synthetic diamond detector (PTW microDiamond) in high-energy scanned clinical carbon ion beams generated by a synchrotron at the CNAO facility. Methods: The detector response was evaluated in a water phantom with actively scanned carbon ion beams ranging from 115 to 380 MeV/u (30–250 mm Bragg peak depth in water). Homogeneous square fields of 3 × 3 and 6 × 6 cm{sup 2} were used. Short- and medium-term (2 months) detector response stability, dependence on beam energy as well as ion type (carbon ions and protons), linearity with dose, and directional and dose-rate dependence were investigated. The depth dose curve of a 280 MeV/u carbon ion beam, scanned over a 3 × 3 cm{sup 2} area, was measured with the microDiamond detector and compared to that measured using a PTW Advanced Markus ionization chamber, and also simulated using FLUKA Monte Carlo code. The detector response in two spread-out-Bragg-peaks (SOBPs), respectively, centered at 9 and 21 cm depths in water and calculated using the treatment planning system (TPS) used at CNAO, was measured. Results: A negligible drift of detector sensitivity within the experimental session was seen, indicating that no detector preirradiation was needed. Short-term response reproducibility around 1% (1 standard deviation) was found. Only 2% maximum variation of microDiamond sensitivity was observed among all the evaluated proton and carbon ion beam energies. The detector response showed a good linear behavior. Detector sensitivity was found to be dose-rate independent, with a variation below 1.3% in the evaluated dose-rate range. A very good agreement between measured and simulated Bragg curves with both microDiamond and Advanced Markus chamber was found, showing a negligible LET dependence of the tested detector. A depth dose curve was also measured by positioning the microDiamond with its main axis oriented orthogonally to the beam

  14. Surface damage through grazing incidence ions investigated by scanning tunneling microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Redinger, Alex

    2009-07-10

    Surface damage, caused by grazing incidence ions, is investigated with variable temperature scanning tunneling microscopy. The experiments are carried out on a Pt(111) crystal. The kinetic energy of noble gas ions is varied between 1-15 keV and the angle of incidence can be adjusted between {theta} = 78.5 and {theta} = 90 measured with respect to the surface normal. The damage patterns of single ion impacts, on flat terraces and at step edges of monoatomic height, are investigated at low surface temperatures. Ions hitting a flat terrace are usually specular reflected. The energy transfer from the ion to the crystal atoms is small and only little damage is produced. In contrast, at ascending step edges, which are illuminated by the ion beam, large angle scattering events occur. Sputtering, adatom and vacancy production is induced. However, a significant fraction of the ions, which hit step edges, enter the crystal and are guided in between two atomic layers parallel to the surface via small angle binary collisions. This steering process is denoted as subsurface channeling. The energy loss per length scale of the channeled particles is low, which results in long ion trajectories (up to 1000A). During the steering process, the ions produce surface damage. Depending on the ion species and the ion energy, adatom and vacancies or surface vacancy trenches of monoatomic width are observed. The surface damage can be used to track the path of the ion. This makes the whole trajectory of single ions with keV energy visible. The number of sputtered atoms per incident ion at ascending step edges, i.e. the step edge sputtering yield, is measured experimentally for different irradiation conditions. For {theta} = 86 , the sputtering yield is determined from the fluence dependent retraction of pre-existing illuminated step edges. An alternative method for the step edge sputtering yield determination, is the analysis of the concentration of ascending steps and of the removed amount

  15. Surface damage through grazing incidence ions investigated by scanning tunneling microscopy

    International Nuclear Information System (INIS)

    Surface damage, caused by grazing incidence ions, is investigated with variable temperature scanning tunneling microscopy. The experiments are carried out on a Pt(111) crystal. The kinetic energy of noble gas ions is varied between 1-15 keV and the angle of incidence can be adjusted between θ = 78.5 and θ = 90 measured with respect to the surface normal. The damage patterns of single ion impacts, on flat terraces and at step edges of monoatomic height, are investigated at low surface temperatures. Ions hitting a flat terrace are usually specular reflected. The energy transfer from the ion to the crystal atoms is small and only little damage is produced. In contrast, at ascending step edges, which are illuminated by the ion beam, large angle scattering events occur. Sputtering, adatom and vacancy production is induced. However, a significant fraction of the ions, which hit step edges, enter the crystal and are guided in between two atomic layers parallel to the surface via small angle binary collisions. This steering process is denoted as subsurface channeling. The energy loss per length scale of the channeled particles is low, which results in long ion trajectories (up to 1000A). During the steering process, the ions produce surface damage. Depending on the ion species and the ion energy, adatom and vacancies or surface vacancy trenches of monoatomic width are observed. The surface damage can be used to track the path of the ion. This makes the whole trajectory of single ions with keV energy visible. The number of sputtered atoms per incident ion at ascending step edges, i.e. the step edge sputtering yield, is measured experimentally for different irradiation conditions. For θ = 86 , the sputtering yield is determined from the fluence dependent retraction of pre-existing illuminated step edges. An alternative method for the step edge sputtering yield determination, is the analysis of the concentration of ascending steps and of the removed amount of material as a

  16. Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma – feasibility and clinical response

    International Nuclear Information System (INIS)

    Photon-based radiation therapy does currently not play a major role as local ablative treatment for hepatocellular carcinoma (HCC). Carbon ions offer distinct physical and biological advantages. Due to their inverted dose profile and the high local dose deposition within the Bragg peak, precise dose application and sparing of normal tissue is possible. Furthermore, carbon ions have an increased relative biological effectiveness (RBE) compared to photons. A total of six patients with one or more HCC-lesions were treated with carbon ions delivered by the raster-scanning technique according to our clinical trial protocol. Diagnosis of HCC was confirmed by histology or two different imaging modalities (CT and MRI) according to the AASLD-guidelines. Applied fractionation scheme was 4 × 10 Gy(RBE). Correct dose application was controlled by in-vivo PET measurement of β + −activity in the irradiated tissue shortly after treatment. Patients were observed for a median time period of 11.0 months (range, 3.4 – 12.7 months). Imaging studies showed a partial response in 4/7 lesions and a stable disease in 3/7 lesions in follow-up CT- and MRI scans. Local control was 100%. One patient with multifocal intrahepatic disease underwent liver transplantation 3 months after carbon ion therapy. During radiotherapy and the follow-up period no severe adverse events have occurred. We report the first clinical results of patients with HCC undergoing carbon ion therapy using the rasterscanning technique at our institution. All patients are locally controlled and experienced no higher toxicities in a short follow-up period. Further patients will be included in our prospective Phase-I clinical trial PROMETHEUS-01 (NCT01167374)

  17. Sliding mode control for an aerodynamic missile based on backstepping design

    Institute of Scientific and Technical Information of China (English)

    Wenjin GU; Hongchao ZHAO; Changpeng PAN

    2005-01-01

    In order to solve the mismatched uncertainties of a class of nonlinear systems,a control method of sliding mode control (SMC) based on the backstepping design is proposed.It introduces SMC in to the last step of backstepping design to modify the backstepping algorithm.This combination not only enables the generalization of the backstepping design to be applied to more general nonlinear systems,but also makes the SMC method become effective in solving the mismatched uncertainties.The SMC based on the backstepping design is applied to the flight control system design of an aerodynamic missile.The control system is researched through simulation.The simulation results show the effectiveness of the proposed control method.

  18. Recursive Backstepping Stabilization of a Wheeled Mobile Robot

    Directory of Open Access Journals (Sweden)

    Faical Mnif

    2008-11-01

    Full Text Available This research is aimed to the development of a dynamic control to enhance the performance of the existing dynamic controllers for mobile robots. System dynamics of the car-like robot with nonholonomic constraints were employed. A Backstepping approach for the design of discontinuous state feedback controller is used for the design of the controller. It is shown that the origin of the closed loop system can be made stable in the sense of Lyapunov. The control design is made on the basis of a suitable Lyapunov function candidate. The effectiveness of the proposed approach is tested through simulation on a car-like vehicle mobile robot.

  19. The Reduced-order Design of Robust Adaptive Backstepping Controller

    Institute of Scientific and Technical Information of China (English)

    WUZhao-Jing; XIEXue-Jun; ZHANGSi-Ying

    2005-01-01

    For a class of systems with unmodeled dynamics, robust adaptive stabilization problem is considered in this paper. Firstly, by a series of coordinate changes, the original system is reparameterized. Then, by introducing a reduced-order observer, an error system is obtained. Based on the system, a reduced-order adaptive backstepping controller design scheme is given. It is proved that all the signals in the adaptive control system are globally uniformly bounded, and the regulation error converges to zero asymptotically. Due to the order deduction of the controller, the design scheme in this paper has more practical values. A simulation example further demonstrates the efficiency of the control scheme.

  20. Adaptive Backstepping Control of Lightweight Tower Wind Turbine

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Borup, Kasper Trolle; Niemann, Hans Henrik;

    2015-01-01

    This paper investigates the feasibility of operating a wind turbine with lightweight tower in the full load region exploiting an adaptive nonlinear controller that allows the turbine to dynamically lean against the wind while maintaining nominal power output. The use of lightweight structures...... for towers and foundations would greatly reduce the construction cost of the wind turbine, however extra features ought be included in the control system architecture to avoid tower collapse. An adaptive backstepping collective pitch controller is proposed for tower point tracking control, i.e. to modify...

  1. Millimeter length micromachining using a heavy ion nuclear microprobe with standard magnetic scanning

    International Nuclear Information System (INIS)

    In order to increase the scanning length of our microprobe, we have developed an irradiation procedure suitable for use in any nuclear microprobe, extending at least up to 400% the length of our heavy ion direct writing facility using standard magnetic exploration. Although this method is limited to patterns of a few millimeters in only one direction, it is useful for the manufacture of curved waveguides, optical devices such Mach–Zehnder modulators, directional couplers as well as channels for micro-fluidic applications. As an example, this technique was applied to the fabrication of 3 mm 3D-Mach–Zehnder modulators in lithium niobate with short Y input/output branches and long shaped parallel-capacitor control electrodes. To extend and improve the quality of the machined structures we developed new scanning control software in LabView™ platform. The new code supports an external dose normalization, electrostatic beam blanking and is capable of scanning figures at 16 bit resolution using a National Instruments™ PCI-6731 High-Speed I/O card. A deep and vertical micromachining process using swift 35Cl ions 70 MeV bombarding energy and direct write patterning was performed on LiNbO3, a material which exhibits a strong natural anisotropy to conventional etching. The micromachined structures show the feasibility of this method for manufacturing micro-fluidic channels as well

  2. Millimeter length micromachining using a heavy ion nuclear microprobe with standard magnetic scanning

    Energy Technology Data Exchange (ETDEWEB)

    Nesprías, F. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Debray, M.E., E-mail: debray@tandar.cnea.gov.ar [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Escuela de Ciencia y Tecnología. Universidad Nacional de Gral. San Martín, M. De Irigoyen 3100 (1650), San Martín, Buenos Aires (Argentina); Davidson, J. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (C1033AAJ), Ciudad Autónoma de Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Escuela de Ciencia y Tecnología. Universidad Nacional de Gral. San Martín, M. De Irigoyen 3100 (1650), San Martín, Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (C1033AAJ), Ciudad Autónoma de Buenos Aires (Argentina); and others

    2013-04-01

    In order to increase the scanning length of our microprobe, we have developed an irradiation procedure suitable for use in any nuclear microprobe, extending at least up to 400% the length of our heavy ion direct writing facility using standard magnetic exploration. Although this method is limited to patterns of a few millimeters in only one direction, it is useful for the manufacture of curved waveguides, optical devices such Mach–Zehnder modulators, directional couplers as well as channels for micro-fluidic applications. As an example, this technique was applied to the fabrication of 3 mm 3D-Mach–Zehnder modulators in lithium niobate with short Y input/output branches and long shaped parallel-capacitor control electrodes. To extend and improve the quality of the machined structures we developed new scanning control software in LabView™ platform. The new code supports an external dose normalization, electrostatic beam blanking and is capable of scanning figures at 16 bit resolution using a National Instruments™ PCI-6731 High-Speed I/O card. A deep and vertical micromachining process using swift {sup 35}Cl ions 70 MeV bombarding energy and direct write patterning was performed on LiNbO{sub 3}, a material which exhibits a strong natural anisotropy to conventional etching. The micromachined structures show the feasibility of this method for manufacturing micro-fluidic channels as well.

  3. Robust adaptive backstepping control for reentry reusable launch vehicles

    Science.gov (United States)

    Wang, Zhen; Wu, Zhong; Du, Yijiang

    2016-09-01

    During the reentry process of reusable launch vehicles (RLVs), the large range of flight envelope will not only result in high nonlinearities, strong coupling and fast time-varying characteristics of the attitude dynamics, but also result in great uncertainties in the atmospheric density, aerodynamic coefficients and environmental disturbances, etc. In order to attenuate the effects of these problems on the control performance of the reentry process, a robust adaptive backstepping control (RABC) strategy is proposed for RLV in this paper. This strategy consists of two-loop controllers designed via backstepping method. Both the outer and the inner loop adopt a robust adaptive controller, which can deal with the disturbances and uncertainties by the variable-structure term with the estimation of their bounds. The outer loop can track the desired attitude by the design of virtual control-the desired angular velocity, while the inner one can track the desired angular velocity by the design of control torque. Theoretical analysis indicates that the closed-loop system under the proposed control strategy is globally asymptotically stable. Even if the boundaries of the disturbances and uncertainties are unknown, the attitude can track the desired value accurately. Simulation results of a certain RLV demonstrate the effectiveness of the control strategy.

  4. Adaptive backstepping slide mode control of pneumatic position servo system

    Science.gov (United States)

    Ren, Haipeng; Fan, Juntao

    2016-06-01

    With the price decreasing of the pneumatic proportional valve and the high performance micro controller, the simple structure and high tracking performance pneumatic servo system demonstrates more application potential in many fields. However, most existing control methods with high tracking performance need to know the model information and to use pressure sensor. This limits the application of the pneumatic servo system. An adaptive backstepping slide mode control method is proposed for pneumatic position servo system. The proposed method designs adaptive slide mode controller using backstepping design technique. The controller parameter adaptive law is derived from Lyapunov analysis to guarantee the stability of the system. A theorem is testified to show that the state of closed-loop system is uniformly bounded, and the closed-loop system is stable. The advantages of the proposed method include that system dynamic model parameters are not required for the controller design, uncertain parameters bounds are not need, and the bulk and expensive pressure sensor is not needed as well. Experimental results show that the designed controller can achieve better tracking performance, as compared with some existing methods.

  5. A Backstepping Simple Adaptive Control Application to Flexible Space Structures

    Institute of Scientific and Technical Information of China (English)

    LIU Min; XU Shijie; HAN Chao

    2012-01-01

    Although the simple adaptive control (SAC) is widely studied both in theory and application in flexible space structure control and other control problems,it is restricted by the almost strictly positive real (ASPR) conditions.In most practical control problems,the ASPR conditions are not satisfied.Therefore,based on the SAC theory,this paper proposes a backstepping simple adaptive control algorithm which suits the system with arbitrary relative degree with no need of parallel feedforward compensator.The proposed control algorithm consists of decomposition of the arbitrary relative degree system into a known subsystem and an unknown ASPR subsystem which are eonneeted in cascade,design of constant outpul feedback controller for the known subsystem,and implementation of backstepping method and SAC of the unknown ASPR subsystem.Inheriting the characteristics of the SAC,this method can be adaptive online for the parameter uncertainties.Then,the application of the proposed controller to large flexible space structure with collocated sensors and actuators is studied,and the simulation results validate the proposed controller.It is a new strategy to apply the classical SAC to high relative degree plants.

  6. Active spot-scanning test with heavy ions at HIRFL-CSR

    International Nuclear Information System (INIS)

    An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR, where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice. The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR. In this paper, the verification of active energy variation and the calibration of steerable beam deflection are shown, as the basic functionality components of the active spot-scanning system. Additionally, based on the capability of creating homogeneous irradiation fields with steerable pencil beams, a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries. (authors)

  7. Simultaneous Scanning Ion Conductance Microscopy and Atomic Force Microscopy with Microchanneled Cantilevers

    Science.gov (United States)

    Ossola, Dario; Dorwling-Carter, Livie; Dermutz, Harald; Behr, Pascal; Vörös, János; Zambelli, Tomaso

    2015-12-01

    We combined scanning ion conductance microscopy (SICM) and atomic force microscopy (AFM) into a single tool using AFM cantilevers with an embedded microchannel flowing into the nanosized aperture at the apex of the hollow pyramid. An electrode was positioned in the AFM fluidic circuit connected to a second electrode in the bath. We could thus simultaneously measure the ionic current and the cantilever bending (in optical beam deflection mode). First, we quantitatively compared the SICM and AFM contact points on the approach curves. Second, we estimated where the probe in SICM mode touches the sample during scanning on a calibration grid and applied the finding to image a network of neurites on a Petri dish. Finally, we assessed the feasibility of a double controller using both the ionic current and the deflection as input signals of the piezofeedback. The experimental data were rationalized in the framework of finite elements simulations.

  8. Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons.

    Directory of Open Access Journals (Sweden)

    Bohumil Maco

    Full Text Available Correlating in vivo imaging of neurons and their synaptic connections with electron microscopy combines dynamic and ultrastructural information. Here we describe a semi-automated technique whereby volumes of brain tissue containing axons and dendrites, previously studied in vivo, are subsequently imaged in three dimensions with focused ion beam scanning electron microcopy. These neurites are then identified and reconstructed automatically from the image series using the latest segmentation algorithms. The fast and reliable imaging and reconstruction technique avoids any specific labeling to identify the features of interest in the electron microscope, and optimises their preservation and staining for 3D analysis.

  9. In situ nanomechanical testing in focused ion beam and scanning electron microscopes

    Energy Technology Data Exchange (ETDEWEB)

    Gianola, D. S. [Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Institute for Applied Materials, Karlsruhe Institute of Technology, Karlsruhe (Germany); Sedlmayr, A.; Moenig, R.; Kraft, O. [Institute for Applied Materials, Karlsruhe Institute of Technology, Karlsruhe (Germany); Volkert, C. A. [Institute for Materials Physics, Georg-August University of Goettingen, Goettingen (Germany); Major, R. C.; Cyrankowski, E.; Asif, S. A. S.; Warren, O. L. [Hysitron, Inc., Minneapolis, Minnesota 55344 (United States)

    2011-06-15

    The recent interest in size-dependent deformation of micro- and nanoscale materials has paralleled both technological miniaturization and advancements in imaging and small-scale mechanical testing methods. Here we describe a quantitative in situ nanomechanical testing approach adapted to a dual-beam focused ion beam and scanning electron microscope. A transducer based on a three-plate capacitor system is used for high-fidelity force and displacement measurements. Specimen manipulation, transfer, and alignment are performed using a manipulator, independently controlled positioners, and the focused ion beam. Gripping of specimens is achieved using electron-beam assisted Pt-organic deposition. Local strain measurements are obtained using digital image correlation of electron images taken during testing. Examples showing results for tensile testing of single-crystalline metallic nanowires and compression of nanoporous Au pillars will be presented in the context of size effects on mechanical behavior and highlight some of the challenges of conducting nanomechanical testing in vacuum environments.

  10. In situ nanomechanical testing in focused ion beam and scanning electron microscopes.

    Science.gov (United States)

    Gianola, D S; Sedlmayr, A; Mönig, R; Volkert, C A; Major, R C; Cyrankowski, E; Asif, S A S; Warren, O L; Kraft, O

    2011-06-01

    The recent interest in size-dependent deformation of micro- and nanoscale materials has paralleled both technological miniaturization and advancements in imaging and small-scale mechanical testing methods. Here we describe a quantitative in situ nanomechanical testing approach adapted to a dual-beam focused ion beam and scanning electron microscope. A transducer based on a three-plate capacitor system is used for high-fidelity force and displacement measurements. Specimen manipulation, transfer, and alignment are performed using a manipulator, independently controlled positioners, and the focused ion beam. Gripping of specimens is achieved using electron-beam assisted Pt-organic deposition. Local strain measurements are obtained using digital image correlation of electron images taken during testing. Examples showing results for tensile testing of single-crystalline metallic nanowires and compression of nanoporous Au pillars will be presented in the context of size effects on mechanical behavior and highlight some of the challenges of conducting nanomechanical testing in vacuum environments.

  11. Development of scanning irradiation in Gunma University Heavy Ion Medical Center

    International Nuclear Information System (INIS)

    Spot scanning irradiation system of carbon ion beam has been developed in Gunma University Heavy Ion Medical Center. During 2013, the beam size and position was stabilized with the use of a pattern-excited steering magnet and optimization of the optic parameters. After these improvement, 3-dimensional spherical field uniform irradiation was carried out based on the measurement of pencil beam profile and depth-dose distribution. The irradiated dose distribution agreed with the calculation within 3%. An experiment of rotating energy absorber has been carried out to suppress the range variation in the extraction period. In order to improve the dose linearity and reproducibility in the low dose region less than 1Gy, the response of I/V converter circuit was improved from 3kHz to 50kHz. After these improvement, the uniform box irradiation was utilized routinely for the animal (mice) experiment from April 2014. (author)

  12. Focused ion beam (FIB)/scanning electron microscopy (SEM) in tissue structural research.

    Science.gov (United States)

    Leser, Vladka; Milani, Marziale; Tatti, Francesco; Tkalec, Ziva Pipan; Strus, Jasna; Drobne, Damjana

    2010-10-01

    The focused ion beam (FIB) and scanning electron microscope (SEM) are commonly used in material sciences for imaging and analysis of materials. Over the last decade, the combined FIB/SEM system has proven to be also applicable in the life sciences. We have examined the potential of the focused ion beam/scanning electron microscope system for the investigation of biological tissues of the model organism Porcellio scaber (Crustacea: Isopoda). Tissue from digestive glands was prepared as for conventional SEM or as for transmission electron microscopy (TEM). The samples were transferred into FIB/SEM for FIB milling and an imaging operation. FIB-milled regions were secondary electron imaged, back-scattered electron imaged, or energy dispersive X-ray (EDX) analyzed. Our results demonstrated that FIB/SEM enables simultaneous investigation of sample gross morphology, cell surface characteristics, and subsurface structures. The same FIB-exposed regions were analyzed by EDX to provide basic compositional data. When samples were prepared as for TEM, the information obtained with FIB/SEM is comparable, though at limited magnification, to that obtained from TEM. A combination of imaging, micro-manipulation, and compositional analysis appears of particular interest in the investigation of epithelial tissues, which are subjected to various endogenous and exogenous conditions affecting their structure and function. The FIB/SEM is a promising tool for an overall examination of epithelial tissue under normal, stressed, or pathological conditions.

  13. Nonlinear Field Oriented Control of Induction Motors using the Backstepping Design

    DEFF Research Database (Denmark)

    Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

    1999-01-01

    Using backstepping, which is a recursive nonlinear design method, a novel approach to control of induction motors is developed. The resulting scheme leads to a nonlinear controller for the torque and the amplitude of the field. A combination of nonlinear damping and observer backstepping with a s......Using backstepping, which is a recursive nonlinear design method, a novel approach to control of induction motors is developed. The resulting scheme leads to a nonlinear controller for the torque and the amplitude of the field. A combination of nonlinear damping and observer backstepping...... with a simple flux observer is used in the design. Assuming known motor parameters the design achieves stabilioty with garanteed region of attraction. It is also shown how a conventional field oriented controller may be obtained by omitting parts of the nonlinear controller....

  14. Backstepping Adaptive Controller of Electro-Hydraulic Servo System of Continuous Rotary Motor

    Institute of Scientific and Technical Information of China (English)

    XiaoJing Wang; ChangFu Xian; CaoLei Wan; JinBao Zhao; LiWei Xiu; AnCai Yu

    2014-01-01

    In order to consider the influence of the continuous rotary motor electro-hydraulic servo system parameters change on its performance, the design method of backstepping adaptive controller is put forward. The mathematical model of electro-hydraulic servo system of continuous rotary motor is established, and the whole system is decomposed into several lower order subsystems, and the virtual control signal is designed for each subsystem from the final subsystem with motor angular displacement to the subsystem with system control input voltage. Based on Lyapunov method and the backstepping theory, an adaptive backstepping controller is designed with the changed parameters adaptive law. It is proved that the system reaches the global asymptotic stability, and the system tracking error asymptotically tends to zero. The simulation results show that the backstepping adaptive controller based on the adaptive law of the changed parameters can improve the performance of continuous rotary motor, and the proposed control strategy is feasible.

  15. Subsurface Examination of a Foliar Biofilm Using Scanning Electron- and Focused-Ion-Beam Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, Patricia K.; Arey, Bruce W.; Mahaffee, Walt F.

    2011-08-01

    The dual beam scanning electron microscope, equipped with both a focused ion- and scanning electron- beam (FIB SEM) is a novel tool for the exploration of the subsurface structure of biological tissues. The FIB can remove a predetermined amount of material from a selected site to allow for subsurface exploration and when coupled with SEM or scanning ion- beam microscopy (SIM) could be suitable to examine the subsurface structure of bacterial biofilms on the leaf surface. The suitability of chemical and cryofixation was examined for use with the FIB SEM to examine bacterial biofilms on leaf surfaces. The biological control agent, Burkholderia pyroccinia FP62, that rapidly colonizes the leaf surface and forms biofilms, was inoculated onto geranium leaves and incubated in a greenhouse for 7 or 14 days. Cryofixation was not suitable for examination of leaf biofilms because it created a frozen layer over the leaf surface that cracked when exposed to the electron beam and the protective cap required for FIB milling could not be accurately deposited. With chemically fixed samples, it was possible to precisely FIB mill a single cross section (5 µm) or sequential cross sections from a single site without any damage to the surrounding surface. Biofilms, 7 days post-inoculation (DPI), were composed of 2 to 5 bacterial cell layers while biofilms 14 DPI ranged from 5 to greater than 30 cell layers. Empty spaces between bacteria cells in the subsurface structure were observed in biofilms 7- and 14-DPI. Sequential cross sections inferred that the empty spaces were often continuous between FP62 cells and could possibly make up a network of channels throughout the biofilm. FIB SEM was a useful tool to observe the subsurface composition of a foliar biofilm.

  16. Decentralized Neural Backstepping Control Applied to a Robot Manipulator

    Directory of Open Access Journals (Sweden)

    Ramon Garcia-Hernandez

    2013-01-01

    Full Text Available This paper presents a discrete‐time decentralized control scheme for trajectory tracking of a two degrees of freedom (DOF robot manipulator. A high order neural network (HONN is used to approximate a decentralized control law designed by the backstepping technique as applied to a block strict feedback form (BSFF. The weights for each neural network are adapted online by an extended Kalman filter training algorithm. The motion for each joint is controlled independently using only local angular position and velocity measurements. The stability analysis for the closed‐loop system via the Lyapunov approach is included. Finally, the real‐time results show the feasibility of the proposed control scheme using a robot manipulator.

  17. Control of Higher–Dimensional PDEs Flatness and Backstepping Designs

    CERN Document Server

    Meurer, Thomas

    2013-01-01

    This monograph presents new model-based design methods for trajectory planning, feedback stabilization, state estimation, and tracking control of distributed-parameter systems governed by partial differential equations (PDEs). Flatness and backstepping techniques and their generalization to PDEs with higher-dimensional spatial domain lie at the core of this treatise. This includes the development of systematic late lumping design procedures and the deduction of semi-numerical approaches using suitable approximation methods. Theoretical developments are combined with both simulation examples and experimental results to bridge the gap between mathematical theory and control engineering practice in the rapidly evolving PDE control area. The text is divided into five parts featuring: - a literature survey of paradigms and control design methods for PDE systems - the first principle mathematical modeling of applications arising in heat and mass transfer, interconnected multi-agent systems, and piezo-actuated smar...

  18. Backstepping tracking control for nonlinear time-delay systems

    Institute of Scientific and Technical Information of China (English)

    Chen Weisheng; Li Junmin

    2006-01-01

    Two design approaches of state feedback and output feedback tracking controllers are proposed for a class of strict feedback nonlinear time-delay systems by using backstepping technique. When the states of system cannot be observed, the time-delay state observer is designed to estimate the system states. Domination method is used to deal with nonlinear time-delay function under the assumption that the nonlinear time-delay functions of systems satisfy Lipschitz condition. The global asymptotical tracking of the references signal is achieved and the bound of all signals of the resultant closed-loop system is also guaranteed. By constructing a Lyapunov-Krasoviskii functional, the stability of the closed-loop system is proved. The feasibility of the proposed approach is illustrated by a simulation example.

  19. Flocking of multiple mobile robots based on backstepping.

    Science.gov (United States)

    Dong, Wenjie

    2011-04-01

    This paper considers the flocking of multiple nonholonomic wheeled mobile robots. Distributed controllers are proposed with the aid of backstepping techniques, results from graph theory, and singular perturbation theory. The proposed controllers can make the states of a group of robots converge to a desired geometric pattern whose centroid moves along a desired trajectory under the condition that the desired trajectory is available to a portion of the group of robots. Since communication delay is inevitable in distributed control, its effect on the performance of the closed-loop systems is analyzed. It is shown that the proposed controllers work well if communication delays are constant. To show effectiveness of the proposed controllers, simulation results are included.

  20. Adaptive Backstepping controller design and implementation for a matrix-converter-based IM drive system

    OpenAIRE

    R.R. Joshi; R.A. Gupta; A.K. Wadhwani

    2007-01-01

    A systematic controller design and implementation for a matrix-converter-based induction motor drive system is proposed. A nonlinear adaptive backstepping controller is proposed to improve the speed and position responses of the induction motor system. By using the proposed adaptive backstepping controller, the system can track a time-varying speed command and a time-varying position command well. Moreover, the system has a good load disturbance rejection capability. The realization of the co...

  1. Adaptive Backstepping design of an Observer for the Rotor Speed and Field of an Induction Motor

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    2001-01-01

    is de-veloped. The resulting scheme leads to a nonlinear full order observer for the rotor field. The rotor speed and the stator resis-tance are estimated by adaptive backstepping. Assuming motor parameters known the design achieves stability with guaran-teed region of attraction. The adaptive...... backstepping observer is used in a rotor field oriented controller and robustness due to variation of motor parameters is analysed by simulation....

  2. Dynamic surface control-backstepping based impedance control for 5-DOF flexible joint robots

    Institute of Scientific and Technical Information of China (English)

    XIONG Gen-liang; XIE Zong-wu; HUANG Jian-bin; LIU Hong; JIANG Zai-nan; SUN Kui

    2010-01-01

    A new impedance controller based on the dynamic surface control-backstepping technique to actualize the anticipant dynamic relationship between the motion of end-effector and the external torques was presented.Comparing with the traditional backstepping method that has"explosion of terms"problem,the new proposed control system is a combination of the dynamic surface control technique and the backstepping.The dynamic surface control(DSC)technique can resolve the"explosion of terms"problem that is caused by differential coefficient calculation in the model,and the problem can bring a complexity that will cause the backstepping method hardly to be applied to the practical application,especially to the multi-joint robot.Finally,the validity of the method was proved in the laboratory environment that was set up on the 5-DOF(degree of freedom)flexible joint robot.Tracking errors of DSC-backstepping impedance control that were 2.0 and 1.5 mm are better than those of backstepping impedance control which were 3.5 and 2.5 nun in directions X,Y in free space,respectively.And the anticipant Cartesian impedance behavior and compliant behavior were achieved successfully as depicted theoretically.

  3. Scanning electrochemical microscopy of metallic biomaterials: reaction rate and ion release imaging modes.

    Science.gov (United States)

    Gilbert, J L; Smith, S M; Lautenschlager, E P

    1993-11-01

    The Scanning Electrochemical Microscope (SECM) is a nonoptical scanning microscopic instrument capable of imaging highly localized electrical currents associated with charge transfer reactions on metallic biomaterials surfaces. The SECM operates as an aqueous electrochemical cell under bipotentiostatic control with a microelectrode and sample independently biased as working electrodes. Microelectrode current and position is recorded as it is scanned very near a metallurgically polished planar sample surface. To date, the SECM has imaged metallic biomaterials surfaces in oxygen reaction rate imaging (ORRI) and ion release and deposition imaging (IRDI) modes. In ORRI, sample and microelectrode are biased at sufficiently negative potentials to reduce absorbed oxygen. As the microelectrode scans areas of active oxygen reduction, localized diffusion fields with decreased oxygen solution concentrations are encountered and resultant decrements in microelectrode current are observed. In IRDI mode the sample is positively biased and the microelectrode is negatively biased. The microelectrode detects anodic dissolution products with highest currents being observed over the most active areas. Performance of the SECM has been evaluated on Ni minigrids, gamma-1 Hg-Ag dental amalgam crystals, and sintered beads of Co-Cr-Mo alloy which represent significantly different geometries and corrosion processes to help demonstrate the potential of this instrument. The SECM is a valuable tool for imaging microelectrochemical processes on the surfaces of metallurgically polished metallic biomaterials samples and a wide variety of other surfaces of biological interest where charge transfer reactions occur. The SECM allows selective biasing of metallic biomaterials surfaces and Faradaic reactions can be selectively imaged while the surface is in the active, passive, or transpassive state. PMID:8262998

  4. Scanning electrochemical microscopy of metallic biomaterials: reaction rate and ion release imaging modes.

    Science.gov (United States)

    Gilbert, J L; Smith, S M; Lautenschlager, E P

    1993-11-01

    The Scanning Electrochemical Microscope (SECM) is a nonoptical scanning microscopic instrument capable of imaging highly localized electrical currents associated with charge transfer reactions on metallic biomaterials surfaces. The SECM operates as an aqueous electrochemical cell under bipotentiostatic control with a microelectrode and sample independently biased as working electrodes. Microelectrode current and position is recorded as it is scanned very near a metallurgically polished planar sample surface. To date, the SECM has imaged metallic biomaterials surfaces in oxygen reaction rate imaging (ORRI) and ion release and deposition imaging (IRDI) modes. In ORRI, sample and microelectrode are biased at sufficiently negative potentials to reduce absorbed oxygen. As the microelectrode scans areas of active oxygen reduction, localized diffusion fields with decreased oxygen solution concentrations are encountered and resultant decrements in microelectrode current are observed. In IRDI mode the sample is positively biased and the microelectrode is negatively biased. The microelectrode detects anodic dissolution products with highest currents being observed over the most active areas. Performance of the SECM has been evaluated on Ni minigrids, gamma-1 Hg-Ag dental amalgam crystals, and sintered beads of Co-Cr-Mo alloy which represent significantly different geometries and corrosion processes to help demonstrate the potential of this instrument. The SECM is a valuable tool for imaging microelectrochemical processes on the surfaces of metallurgically polished metallic biomaterials samples and a wide variety of other surfaces of biological interest where charge transfer reactions occur. The SECM allows selective biasing of metallic biomaterials surfaces and Faradaic reactions can be selectively imaged while the surface is in the active, passive, or transpassive state.

  5. Scanning electron microscopy of the surfaces of ion implanted SiC

    Energy Technology Data Exchange (ETDEWEB)

    Malherbe, Johan B., E-mail: johan.malherbe@up.ac.za [Department of Physics, University of Pretoria, Pretoria 0002 (South Africa); Berg, N.G. van der; Kuhudzai, R.J.; Hlatshwayo, T.T.; Thabethe, T.T.; Odutemowo, O.S.; Theron, C.C.; Friedland, E. [Department of Physics, University of Pretoria, Pretoria 0002 (South Africa); Botha, A.J. [Laboratory for Microscopy & Microanalysis, University of Pretoria, Pretoria 0002 (South Africa); Wendler, E. [Institut für Festkörperphysik, Friedrich-Schiller-Universität Jena, 07743 Jena (Germany)

    2015-07-01

    This paper gives a brief review of radiation damage caused by particle (ions and neutrons) bombardment in SiC at different temperatures, and its annealing, with an expanded discussion on the effects occurring on the surface. The surface effects were observed using SEM (scanning electron microscopy) with an in-lens detector and EBSD (electron backscatter diffraction). Two substrates were used, viz. single crystalline 6H-SiC wafers and polycrystalline SiC, where the majority of the crystallites were 3C-SiC. The surface modification of the SiC samples by 360 keV ion bombardment was studied at temperatures below (i.e. room temperature), just at (i.e. 350 °C), or above (i.e. 600 °C) the critical temperature for amorphization of SiC. For bombardment at a temperature at about the critical temperature an extra step, viz. post-bombardment annealing, was needed to ascertain the microstructure of bombarded layer. Another aspect investigated was the effect of annealing of samples with an ion bombardment-induced amorphous layer on a 6H-SiC substrate. SEM could detect that this layer started to crystalize at 900 °C. The resulting topography exhibited a dependence on the ion species. EBSD showed that the crystallites forming in the amorphized layer were 3C-SiC and not 6H-SiC as the substrate. The investigations also pointed out the behaviour of the epitaxial regrowth of the amorphous layer from the 6H-SiC interface.

  6. Non-invasive scanning ion-selective electrode technique and its applications to the research of higher plants

    Institute of Scientific and Technical Information of China (English)

    Sun Tong; Xu Yue; Li Peng; Yu Shangguan; Yin Liping

    2007-01-01

    The process of various ions and molecules getting into and out of cells is critical for plant survival. The non-invasive scanning ion-selective electrode technique (SIET) is a non-invasive method to obtain the information of ions/molecules across membranes in plant. This technique can measure the absolute concentration of ions and molecules, and also their fluxes and directions of movement.The samples to be analyzed can be a single cell, a piece of tissue, a whole organ and even an intact seedling. This article reviews the recent progress made in plant physiology by using this technique and discusses its potentials in future studies on plant physiology.

  7. Internal composition of atmospheric dust particles from focused ion-beam scanning electron microscopy.

    Science.gov (United States)

    Conny, Joseph M

    2013-08-01

    Use of focused ion-beam scanning electron microscopy (FIB-SEM) to investigate the internal composition of atmospheric particles is demonstrated for assessing particle optical properties. In the FIB-SEM instrument equipped with an X-ray detector, a gallium-ion beam mills the particle, while the electron beam images the slice faces and energy-dispersive X-ray spectroscopy provides element maps of the particle. Differences in assessments of optical behavior based on FIB-SEM and conventional SEM were shown for five selected urban dust particles. The benefit of FIB-SEM for accurately determining the depth and size of optically important phases within particles was shown. FIB-SEM revealed that iron oxide grains left undetected by conventional SEM could potentially shift the single-scattering albedo of the particle from negative to positive radiative forcing. Analysis of a coke-like particle showed that 73% of the light-scattering inclusion went undetected with conventional SEM, causing the bulk absorption coefficient to vary by as much as 25%. Optical property calculations for particles as volume-equivalent spheres and as spheroids that approximated actual particle shapes revealed that the largest effect between conventional SEM and FIB-SEM analyses was on backscattering efficiency, in some cases varying several-fold. PMID:23763344

  8. Design High-Efficiency Intelligent PID like Fuzzy Backstepping Controller for Three Dimension Motor

    Directory of Open Access Journals (Sweden)

    Mahsa Piltan

    2014-08-01

    Full Text Available The minimum rule base Proportional Integral Derivative (PID Fuzzy backstepping Controller for three dimensions spherical motor is presented in this research. The popularity of PID Fuzzy backstepping controller can be attributed to their robust performance in a wide range of operating conditions and partly to their functional simplicity. The process of setting of PID Fuzzy backstepping controller can be determined as an optimization task. Over the years, use of intelligent strategies for tuning of these controllers has been growing. PID methodology has three inputs and if any input is described with seven linguistic values, and any rule has three conditions we will need 7 × 7 × 7 = 343 rules. It is too much work to write 343 rules. In this research the PID-like fuzzy controller can be constructed as a parallel structure of a PI-like controller and a PD-like fuzzy controller to have the minimum rule base. However backstepping controller is work based on cancelling decoupling and nonlinear terms of dynamic parameters of each dimension, this controller is work based on spherical motor dynamic model and this technique is highly sensitive to the knowledge of all parameters of nonlinear three dimension spherical motor’s dynamic equation. This research is used to reduce or eliminate the backstepping controller problem based on minimum rule base fuzzy logic theory to control of spherical motor system and testing of the quality of process control in the simulation environment of MATLAB/SIMULINK Simulator.

  9. Backstepping-Based Inverse Optimal Attitude Control of Quadrotor

    Directory of Open Access Journals (Sweden)

    An Honglei

    2013-05-01

    Full Text Available Input saturation must be taken into account for applying rapid reorientation in the large angle manoeuvre of a quadrotor. In this paper, a backstepping‐based inverse optimal attitude controller (BIOAC is derived which has the property of a maximum convergence rate in the sense of a control Lyapunov function (CLF under input torque limitation. In the controller, a backstepping technique is used for handling the complexity introducing by the unit quaternion representation of the attitude of a quadrotor with four parameters. Moreover, the inverse optimal approach is employed to circumvent the difficulty of solving the Hamilton‐Jacobi‐Bellman (HJB equation. The performance of BIOAC is compared with a PD controller in which the input torque limitation is not considered under the same unit quaternion representation using numerical simulation while the results show that BIOAC gains faster convergence with less control effort. Next, BIOAC is realized on a test bed and the effectiveness of the control law is verified by experimental studies.

  10. Simultaneous Interfacial Reactivity and Topography Mapping with Scanning Ion Conductance Microscopy.

    Science.gov (United States)

    Momotenko, Dmitry; McKelvey, Kim; Kang, Minkyung; Meloni, Gabriel N; Unwin, Patrick R

    2016-03-01

    Scanning ion conductance microscopy (SICM) is a powerful technique for imaging the topography of a wide range of materials and interfaces. In this report, we develop the use and scope of SICM, showing how it can be used for mapping spatial distributions of ionic fluxes due to (electro)chemical reactions occurring at interfaces. The basic idea is that there is a change of ion conductance inside a nanopipet probe when it approaches an active site, where the ionic composition is different to that in bulk solution, and this can be sensed via the current flow in the nanopipet with an applied bias. Careful tuning of the tip potential allows the current response to be sensitive to either topography or activity, if desired. Furthermore, the use of a distance modulation SICM scheme allows reasonably faithful probe positioning using the resulting ac response, irrespective of whether there is a reaction at the interface that changes the local ionic composition. Both strategies (distance modulation or tuned bias) allow simultaneous topography-activity mapping with a single channel probe. The application of SICM reaction imaging is demonstrated on several examples, including voltammetric mapping of electrocatalytic reactions on electrodes and high-speed electrochemical imaging at rates approaching 4 s per image frame. These two distinct approaches provide movies of electrochemical current as a function of potential with hundreds of frames (images) of surface reactivity, to reveal a wealth of spatially resolved information on potential- (and time) dependent electrochemical phenomena. The experimental studies are supported by detailed finite element method modeling that places the technique on a quantitative footing.

  11. Cryo DualBeam Focused Ion Beam–Scanning Electron Microscopy to Evaluate the Interface Between Cells and Nanopatterned Scaffolds

    NARCIS (Netherlands)

    Lamers, Edwin; Walboomers, X. Frank; Domanski, Maciej; McKerr, George; O'Hagan, Barry M.; Barnes, Clifford A.; Peto, Lloyd; Lüttge, Regina; Winnubst, Louis A.J.A.; Gardeniers, Han J.G.E.; Jansen, John A.

    2011-01-01

    With the advance of nanotechnology in biomaterials science and tissue engineering, it is essential that new techniques become available to observe processes that take place at the direct interface between tissue and scaffold materials. Here, Cryo DualBeam focused ion beam–scanning electron microscop

  12. The influence of lateral beam profile modifications in scanned proton and carbon ion therapy: a Monte Carlo study

    CERN Document Server

    Parodi, K; Kraemer, M; Sommerer, F; Naumann, J; Mairani, A; Brons, S

    2010-01-01

    Scanned ion beam delivery promises superior flexibility and accuracy for highly conformal tumour therapy in comparison to the usage of passive beam shaping systems. The attainable precision demands correct overlapping of the pencil-like beams which build up the entire dose distribution in the treatment field. In particular, improper dose application due to deviations of the lateral beam profiles from the nominal planning conditions must be prevented via appropriate beam monitoring in the beamline, prior to the entrance in the patient. To assess the necessary tolerance thresholds of the beam monitoring system at the Heidelberg Ion Beam Therapy Center, Germany, this study has investigated several worst-case scenarios for a sensitive treatment plan, namely scanned proton and carbon ion delivery to a small target volume at a shallow depth. Deviations from the nominal lateral beam profiles were simulated, which may occur because of misaligned elements or changes of the beam optic in the beamline. Data have been an...

  13. Multi-objective optimal design of high frequency probe for scanning ion conductance microscopy

    Science.gov (United States)

    Guo, Renfei; Zhuang, Jian; Ma, Li; Li, Fei; Yu, Dehong

    2016-01-01

    Scanning ion conductance microscopy(SICM) is an emerging non-destructive surface topography characterization apparatus with nanoscale resolution. However, the low regulating frequency of probe in most existing modulated current based SICM systems increases the system noise, and has difficulty in imaging sample surface with steep height changes. In order to enable SICM to have the capability of imaging surfaces with steep height changes, a novel probe that can be used in the modulated current based hopping mode is designed. The design relies on two piezoelectric ceramics with different travels to separate position adjustment and probe frequency regulation in the Z direction. To further improve the resonant frequency of the probe, the material and the key dimensions for each component of the probe are optimized based on the multi-objective optimization method and the finite element analysis. The optimal design has a resonant frequency of above 10 kHz. To validate the rationality of the designed probe, microstructured grating samples are imaged using the homebuilt modulated current based SICM system. The experimental results indicate that the designed high frequency probe can effectively reduce the spike noise by 26% in the average number of spike noise. The proposed design provides a feasible solution for improving the imaging quality of the existing SICM systems which normally use ordinary probes with relatively low regulating frequency.

  14. Evaluation of mRNA Localization Using Double Barrel Scanning Ion Conductance Microscopy.

    Science.gov (United States)

    Nashimoto, Yuji; Takahashi, Yasufumi; Zhou, Yuanshu; Ito, Hidenori; Ida, Hiroki; Ino, Kosuke; Matsue, Tomokazu; Shiku, Hitoshi

    2016-07-26

    Information regarding spatial mRNA localization in single cells is necessary for a better understanding of cellular functions in tissues. Here, we report a method for evaluating localization of mRNA in single cells using double-barrel scanning ion conductance microscopy (SICM). Two barrels in a nanopipette were filled with aqueous and organic electrolyte solutions and used for SICM and as an electrochemical syringe, respectively. We confirmed that the organic phase barrel could be used to collect cytosol from living cells, which is a minute but sufficient amount to assess cellular status using qPCR analysis. The water phase barrel could be used for SICM to image topography with subcellular resolution, which could be used to determine positions for analyzing mRNA expression. This system was able to evaluate mRNA localization in single cells. After puncturing the cellular membrane in a minimally invasive manner, using SICM imaging as a guide, we collected a small amount cytosol from different positions within a single cell and showed that mRNA expression depends on cellular position. In this study, we show that SICM imaging can be utilized for the analysis of mRNA localization in single cells. In addition, we fully automated the pipet movement in the XYZ-directions during the puncturing processes, making it applicable as a high-throughput system for collecting cytosol and analyzing mRNA localization. PMID:27399804

  15. Multi-resolution correlative focused ion beam scanning electron microscopy: applications to cell biology.

    Science.gov (United States)

    Narayan, Kedar; Danielson, Cindy M; Lagarec, Ken; Lowekamp, Bradley C; Coffman, Phil; Laquerre, Alexandre; Phaneuf, Michael W; Hope, Thomas J; Subramaniam, Sriram

    2014-03-01

    Efficient correlative imaging of small targets within large fields is a central problem in cell biology. Here, we demonstrate a series of technical advances in focused ion beam scanning electron microscopy (FIB-SEM) to address this issue. We report increases in the speed, robustness and automation of the process, and achieve consistent z slice thickness of ∼3 nm. We introduce "keyframe imaging" as a new approach to simultaneously image large fields of view and obtain high-resolution 3D images of targeted sub-volumes. We demonstrate application of these advances to image post-fusion cytoplasmic intermediates of the HIV core. Using fluorescently labeled cell membranes, proteins and HIV cores, we first produce a "target map" of an HIV infected cell by fluorescence microscopy. We then generate a correlated 3D EM volume of the entire cell as well as high-resolution 3D images of individual HIV cores, achieving correlative imaging across a volume scale of 10(9) in a single automated experimental run.

  16. Nano-Tomography of Porous Geological Materials Using Focused Ion Beam-Scanning Electron Microscopy

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2016-10-01

    Full Text Available Tomographic analysis using focused ion beam-scanning electron microscopy (FIB-SEM provides three-dimensional information about solid materials with a resolution of a few nanometres and thus bridges the gap between X-ray and transmission electron microscopic tomography techniques. This contribution serves as an introduction and overview of FIB-SEM tomography applied to porous materials. Using two different porous Earth materials, a diatomite specimen, and an experimentally produced amorphous silica layer on olivine, we discuss the experimental setup of FIB-SEM tomography. We then focus on image processing procedures, including image alignment, correction, and segmentation to finally result in a three-dimensional, quantified pore network representation of the two example materials. To each image processing step we consider potential issues, such as imaging the back of pore walls, and the generation of image artefacts through the application of processing algorithms. We conclude that there is no single image processing recipe; processing steps need to be decided on a case-by-case study.

  17. Active raster scanning with carbon ions. Reirradiation in patients with recurrent skull base chordomas and chondrosarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Uhl, Matthias; Welzel, Thomas; Oelmann, Jan; Habl, Gregor; Hauswald, Henrik; Jensen, Alexandra; Debus, Juergen; Herfarth, Klaus [University of Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Ellerbrock, Malte [Heidelberg Ion Therapy Center (HIT), Heidelberg (Germany)

    2014-07-15

    To evaluate the safety and efficacy of reirradiation with carbon ions in patients with relapse of skull base chordoma and chondrosarcoma. Reirradiation with carbon ions was performed on 25 patients with locally recurrent skull base chordoma (n = 20) or chondrosarcoma (n = 5). The median time between the last radiation exposure and the reirradiation with carbon ions was 7 years. In the past, 23 patients had been irradiated once, two patients twice. Reirradiation was delivered using the active raster scanning method. The total median dose was 51.0 GyE carbon ions in a weekly regimen of five to six fractions of 3 GyE. Local progression-free survival (LPFS) was evaluated using the Kaplan-Meier method; toxicity was evaluated using the NCI Common Terminology Criteria for Adverse Events (CTCAE v.4.03). The treatment could be finished in all patients without interruption. In 80 % of patients, symptom control was achieved after therapy. The 2-year-LPFS probability was 79.3 %. A PTV volume of < 100 ml or a total dose of > 51 GyE was associated with a superior local control rate. The therapy was associated with low acute toxicity. One patient developed grade 2 mucositis during therapy. Furthermore, 12 % of patients had tympanic effusion with mild hypacusis (grade 2), while 20 % developed an asymptomatic temporal lobe reaction after treatment (grade 1). Only one patient showed a grade 3 osteoradionecrosis. Reirradiation with carbon ions is a safe and effective method in patients with relapsed chordoma and chondrosarcoma of the skull base. (orig.) [German] Evaluierung der Sicherheit und Wirksamkeit einer Re-Bestrahlung mittels Kohlenstoffionen bei Patienten mit Lokalrezidiv eines Chordoms und Chondrosarkoms der Schaedelbasis. Bei 25 Patienten mit einem Lokalrezidiv eines Chordoms (n = 20) oder Chondrosarkoms (n = 5) der Schaedelbasis erfolgte eine Re-Bestrahlung mittels Kohlenstoffionen. Die mediane Zeit zwischen letzter Bestrahlung und Re-Bestrahlung mit Kohlenstoffionen

  18. Parametric adaptive estimation and backstepping control of electro-hydraulic actuator with decayed memory filter.

    Science.gov (United States)

    Guo, Qing; Sun, Ping; Yin, Jing-Min; Yu, Tian; Jiang, Dan

    2016-05-01

    Some unknown parameter estimation of electro-hydraulic system (EHS) should be considered in hydraulic controller design due to many parameter uncertainties in practice. In this study, a parametric adaptive backstepping control method is proposed to improve the dynamic behavior of EHS under parametric uncertainties and unknown disturbance (i.e., hydraulic parameters and external load). The unknown parameters of EHS model are estimated by the parametric adaptive estimation law. Then the recursive backstepping controller is designed by Lyapunov technique to realize the displacement control of EHS. To avoid explosion of virtual control in traditional backstepping, a decayed memory filter is presented to re-estimate the virtual control and the dynamic external load. The effectiveness of the proposed controller has been demonstrated by comparison with the controller without adaptive and filter estimation. The comparative experimental results in critical working conditions indicate the proposed approach can achieve better dynamic performance on the motion control of Two-DOF robotic arm.

  19. Identification-based chaos control via backstepping design using self-organizing fuzzy neural networks

    International Nuclear Information System (INIS)

    This paper proposes an identification-based adaptive backstepping control (IABC) for the chaotic systems. The IABC system is comprised of a neural backstepping controller and a robust compensation controller. The neural backstepping controller containing a self-organizing fuzzy neural network (SOFNN) identifier is the principal controller, and the robust compensation controller is designed to dispel the effect of minimum approximation error introduced by the SOFNN identifier. The SOFNN identifier is used to online estimate the chaotic dynamic function with structure and parameter learning phases of fuzzy neural network. The structure learning phase consists of the growing and pruning of fuzzy rules; thus the SOFNN identifier can avoid the time-consuming trial-and-error tuning procedure for determining the neural structure of fuzzy neural network. The parameter learning phase adjusts the interconnection weights of neural network to achieve favorable approximation performance. Finally, simulation results verify that the proposed IABC can achieve favorable tracking performance.

  20. Adaptive variable structure control based on backstepping for spacecraft with reaction wheels during attitude maneuver

    Institute of Scientific and Technical Information of China (English)

    SONG Bin; MA Guang-fu; LI Chuan-jiang

    2009-01-01

    An adaptive variable structure control method based on backstepping is proposed for the attitude maneuver problem of rigid spacecraft with reaction wheel dynamics in the presence of uncertain inertia matrix and external disturbances. The proposed control approach is a combination of the backstepping and the adaptive variable structure control. The cascaded structure of the attitude maneuver control system with reaction wheel dynamics gives the advantage for applying the backstepping method to construct Lyapunov functions. The robust stability to external disturbances and parametric uncertainty is guaranteed by the adaptive variable structure control. To validate the proposed control algorithm, numerical simulations using the proposed approach are performed for the attitude maneuver mission of rigid spacecraft with a configuration consisting of four reaction wheels for actuator and three magnetorquers for momentum unloading. Simulation results verify the effectiveness of the proposed control algorithm.

  1. Parametric adaptive estimation and backstepping control of electro-hydraulic actuator with decayed memory filter.

    Science.gov (United States)

    Guo, Qing; Sun, Ping; Yin, Jing-Min; Yu, Tian; Jiang, Dan

    2016-05-01

    Some unknown parameter estimation of electro-hydraulic system (EHS) should be considered in hydraulic controller design due to many parameter uncertainties in practice. In this study, a parametric adaptive backstepping control method is proposed to improve the dynamic behavior of EHS under parametric uncertainties and unknown disturbance (i.e., hydraulic parameters and external load). The unknown parameters of EHS model are estimated by the parametric adaptive estimation law. Then the recursive backstepping controller is designed by Lyapunov technique to realize the displacement control of EHS. To avoid explosion of virtual control in traditional backstepping, a decayed memory filter is presented to re-estimate the virtual control and the dynamic external load. The effectiveness of the proposed controller has been demonstrated by comparison with the controller without adaptive and filter estimation. The comparative experimental results in critical working conditions indicate the proposed approach can achieve better dynamic performance on the motion control of Two-DOF robotic arm. PMID:26920086

  2. Robust Neural Network Control of Electrically Driven Robot Manipulator using Backstepping Approach

    Directory of Open Access Journals (Sweden)

    Seyed Ehsan Shafiei

    2010-02-01

    Full Text Available A novel approach to neural network based tracking-control of robot manipulator including actuator dynamics is proposed by using of backstepping method. A simple two-step backstepping is considered for an nlink robotic system, and a feedforward neural controller is designed at second step where structured and unstructured uncertainties in robot dynamics and actuator model are approximated by this neural controller. Bounds of network reconstruction error and other imprecisions are estimated adaptively and for compensating them, a robust control signal is added and modified. Stability analysis is performed by the Lyapunov direct method and performance efficiency of the proposed controller is justified by the simulations.

  3. Submicron mass spectrometry imaging of single cells by combined use of mega electron volt time-of-flight secondary ion mass spectrometry and scanning transmission ion microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Siketić, Zdravko; Bogdanović Radović, Ivančica; Jakšić, Milko; Popović Hadžija, Marijana; Hadžija, Mirko [Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb (Croatia)

    2015-08-31

    In order to better understand biochemical processes inside an individual cell, it is important to measure the molecular composition at the submicron level. One of the promising mass spectrometry imaging techniques that may be used to accomplish this is Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), using MeV energy heavy ions for excitation. MeV ions have the ability to desorb large intact molecules with a yield that is several orders of magnitude higher than conventional SIMS using keV ions. In order to increase the spatial resolution of the MeV TOF-SIMS system, we propose an independent TOF trigger using a STIM (scanning transmission ion microscopy) detector that is placed just behind the thin transmission target. This arrangement is suitable for biological samples in which the STIM detector simultaneously measures the mass distribution in scanned samples. The capability of the MeV TOF-SIMS setup was demonstrated by imaging the chemical composition of CaCo-2 cells.

  4. Submicron mass spectrometry imaging of single cells by combined use of mega electron volt time-of-flight secondary ion mass spectrometry and scanning transmission ion microscopy

    International Nuclear Information System (INIS)

    In order to better understand biochemical processes inside an individual cell, it is important to measure the molecular composition at the submicron level. One of the promising mass spectrometry imaging techniques that may be used to accomplish this is Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), using MeV energy heavy ions for excitation. MeV ions have the ability to desorb large intact molecules with a yield that is several orders of magnitude higher than conventional SIMS using keV ions. In order to increase the spatial resolution of the MeV TOF-SIMS system, we propose an independent TOF trigger using a STIM (scanning transmission ion microscopy) detector that is placed just behind the thin transmission target. This arrangement is suitable for biological samples in which the STIM detector simultaneously measures the mass distribution in scanned samples. The capability of the MeV TOF-SIMS setup was demonstrated by imaging the chemical composition of CaCo-2 cells

  5. Application of radiochromic film for quality assurance in the heavy-ion beam scanning irradiation system at HIMAC

    International Nuclear Information System (INIS)

    For the quality assurance (QA) of therapeutic scanned carbon-ion beams, QA tool having high spatial resolution is required. The radiochromic film (such as Gafchromic EBT2 film model) is a very useful tool because of its high spatial resolution, self-development, and near tissue equivalence. However, for a complex field in carbon-ion therapy, it is difficult to unambiguously determine the dose from the measured net optical density (OD). As a first approach, we investigated the response of EBT2 to carbon-ion beam at the Heavy Ion Medical Accelerator in Chiba (HIMAC) in Japan. Based on the measured results, we performed QA measurements independently of dose. We verified the QA measurements by EBT2 by comparing the ionization chamber and the fluorescent screen. The results obtained with EBT2 were in good agreement with those obtained with the other detector. In addition, to test the use in a complex field, we verified the OD distributions for moving and static target by means of a gamma index analysis. As a result, we confirmed that EBT2 could be used as a part of QA procedures for therapeutic scanned carbon-ion beams

  6. Research and design of scanning power supply for deep tumor therapy facility with heavy ions accelerator in Lanzhou

    International Nuclear Information System (INIS)

    This paper describes the technique targets and operation principle of the scanning power supply for the deep tumor therapy facility with heavy ions in Cooler-Storage-Ring of the Heavy Ion Research Facility in Lanzhou (HIRFL-CSR). To ensure the specified accuracy of the current, the hysteresis loop control strategy was adopted, and tracking error was constrained in the specified tolerance. One prototype was designed and installed. And the simulation results and test results were listed in the paper. The results show that all the targets can meet the design requirements, and that the circuit configuration and hysteresis loop control strategy selected are practicable. (authors)

  7. Scanning tunneling microscopy and spectroscopy of ion-bombarded Si(111) and Si(100) surfaces

    NARCIS (Netherlands)

    Zandvliet, H.J.W.; Elswijk, H.B.; Loenen, van E.J.; Tsong, I.S.T.

    1992-01-01

    Surfaces of Si(111)-(7×7) and Si(100)-(2×1) were bombarded by 3-keV Ar+ ions at doses of ≤1012 ions cm-2 to study the effect of individual ion impacts on the atomic structure of surfaces. Atom-resolved images show damaged regions of missing and displaced atoms. Current-imaging tunneling spectroscop

  8. Motion compensation with a scanned ion beam: a technical feasibility study

    OpenAIRE

    Kraft Gerhard; Haberer Thomas; Bert Christoph; Grözinger Sven; Rietzel Eike

    2008-01-01

    Abstract Background Intrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target motion by tracking with the treatment beam. Methods Lateral motion components were compensated directly with the beam scanning system by adapting nominal beam positions according to the target motion. Longitudinal motion compensation to mitigate motion induced range changes was performed with a dedicated w...

  9. Artificial Error Tuning Based on Design a Novel SISO Fuzzy Backstepping Adaptive Variable Structure Control

    Directory of Open Access Journals (Sweden)

    Samaneh Zahmatkesh

    2013-10-01

    Full Text Available This paper examines single input single output (SISO chattering free variable structure control (VSC which controller coefficient is on-line tuned by fuzzy backstepping algorithm to control of continuum robot manipulator. Variable structure methodology is selected as a framework to construct the control law and address the stability and robustness of the close loop system based on Lyapunove formulation. The main goal is to guarantee acceptable error result and adjust the trajectory following. The proposed approach effectively combines the design technique from variable structure controller is based on Lyapunov and modified Proportional plus Derivative (P+D fuzzy estimator to estimate the nonlinearity of undefined system dynamic in backstepping controller. The input represents the function between variable structure function, error and the modified rate of error. The outputs represent joint torque, respectively. The fuzzy backstepping methodology is on-line tune the variable structure function based on adaptive methodology. The performance of the SISO VSC based on-line tuned by fuzzy backstepping algorithm (FBSAVSC is validated through comparison with VSC. Simulation results signify good performance of trajectory in presence of uncertainty joint torque load.

  10. Towards Certifiable Advanced Flight Control Systems, A Sensor Based Backstepping Approach

    NARCIS (Netherlands)

    Falkena, W.; Van Oort, E.R.; Chu, Q.P.

    2011-01-01

    This paper uses singular perturbation theory in order to design a backstepping control system. Earlier applications using singular perturbation theory for control of non-affine systems exist, but here the focus is shifted to uncertain systems. Dealing with uncertainties in this way could be a major

  11. Backstepping-Based Synchronization Control of Cross-Strict Feedback Hyper-Chaotic Systems

    Institute of Scientific and Technical Information of China (English)

    李海燕; 胡云安

    2011-01-01

    A certain backstepping control is proposed for synchronization of a class of hyper-chaotic systems.Only two control inputs are used to realize synchronization between hyper-chaotic systems,and the control avoids the possible singularity in the virtual control design.In addition,the adaptive backstepping control is proposed for the synchronization when the system parameters are unknown.The proposed methods can be applied to a variety of chaos systems which can be described by the so-called cross-strict feedback form.Numerical simulations are given to demonstrate the effciency of the proposed control schemes.%A certain backstepping control is proposed for synchronization of a class of hyper-chaotic systems. Only two control inputs are used to realize synchronization between hyper-chaotic systems, and the control avoids the possible singularity in the virtual control design. In addition, the adaptive backstepping control is proposed for the synchronization when the system parameters are unknown. The proposed methods can be applied to a variety of chaos systems which can be described by the so-called cross-strict feedback form. Numerical simulations are given to demonstrate the efficiency of the proposed control schemes.

  12. Scan-rate-dependent ion current rectification and rectification inversion in charged conical nanopores.

    Science.gov (United States)

    Momotenko, Dmitry; Girault, Hubert H

    2011-09-21

    Herein we report a theoretical study of diode-like behavior of negatively charged (e.g., glass or silica) nanopores at different potential scan rates (1-1000 V·s(-1)). Finite element simulations were used to determine current-voltage characteristics of conical nanopores at various electrolyte concentrations. This study demonstrates that significant changes in rectification behavior can be observed at high scan rates because the mass transport of ionic species appears sluggish on the time scale of the voltage scan. In particular, it explains the influence of the potential scan rate on the nanopore rectifying properties in the cases of classical rectification, rectification inversion, and the "transition" rectification domain where the rectification direction in the nanopore could be modulated according to the applied scan rate.

  13. Fine structures and ion images on fresh frozen dried ultrathin sections by transmission electron and scanning ion microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Takaya, K.; Okabe, M.; Sawataishi, M.; Takashima, H.; Yoshida, T

    2003-01-15

    Ion microscopy (IM) of air-dried or freeze-dried cryostat and semi-thin cryosections has provided ion images of elements and organic substances in wide areas of the tissue. For reproducible ion images by a shorter time of exposure to the primary ion beam, fresh frozen dried ultrathin sections were prepared by freezing the tissue in propane chilled with liquid nitrogen, cryocut at 60 nm, mounted on grids and silicon wafer pieces, and freeze-dried. Rat Cowper gland and sciatic nerve, bone marrow of the rat administered of lithium carbonate, tree frog and African toad spleen and buffy coat of atopic dermatitis patients were examined. Fine structures and ion images of the corresponding areas in the same or neighboring sections were observed by transmission electron microscopy (TEM) followed by sector type and time-of-flight type IM. Cells in the buffy coat contained larger amounts of potassium and magnesium while plasma had larger amounts of sodium and calcium. However, in the tissues, lithium, sodium, magnesium, calcium and potassium were distributed in the cell and calcium showed a granular appearance. A granular cell of the tree frog spleen contained sodium and potassium over the cell and magnesium and calcium were confined to granules.

  14. Investigation of acoustic waves generated in an elastic solid by a pulsed ion beam and their application in a FIB based scanning ion acoustic microscope

    International Nuclear Information System (INIS)

    The aim of this work is to investigate the acoustic wave generation by pulsed and periodically modulated ion beams in different solid materials depending on the beam parameters and to demonstrate the possibility to apply an intensity modulated focused ion beam (FIB) for acoustic emission and for nondestructive investigation of the internal structure of materials on a microscopic scale. The combination of a FIB and an ultrasound microscope in one device can provide the opportunity of nondestructive investigation, production and modification of micro- and nanostructures simultaneously. This work consists of the two main experimental parts. In the first part the process of elastic wave generation during the irradiation of metallic samples by a pulsed beam of energetic ions was investigated in an energy range from 1.5 to 10 MeV and pulse durations of 0.5-5 μs, applying ions with different masses, e.g. oxygen, silicon and gold, in charge states from 1+ to 4+. The acoustic amplitude dependence on the ion beam parameters like the ion mass and energy, the ion charge state, the beam spot size and the pulse duration were of interest. This work deals with ultrasound transmitted in a solid, i.e. bulk waves, because of their importance for acoustic transmission microscopy and nondestructive inspection of internal structure of a sample. The second part of this work was carried out using the IMSA-100 FIB system operating in an energy range from 30 to 70 keV. The scanning ion acoustic microscope based on this FIB system was developed and tested. (orig.)

  15. Investigation of acoustic waves generated in an elastic solid by a pulsed ion beam and their application in a FIB based scanning ion acoustic microscope

    Energy Technology Data Exchange (ETDEWEB)

    Akhmadaliev, C.

    2004-12-01

    The aim of this work is to investigate the acoustic wave generation by pulsed and periodically modulated ion beams in different solid materials depending on the beam parameters and to demonstrate the possibility to apply an intensity modulated focused ion beam (FIB) for acoustic emission and for nondestructive investigation of the internal structure of materials on a microscopic scale. The combination of a FIB and an ultrasound microscope in one device can provide the opportunity of nondestructive investigation, production and modification of micro- and nanostructures simultaneously. This work consists of the two main experimental parts. In the first part the process of elastic wave generation during the irradiation of metallic samples by a pulsed beam of energetic ions was investigated in an energy range from 1.5 to 10 MeV and pulse durations of 0.5-5 {mu}s, applying ions with different masses, e.g. oxygen, silicon and gold, in charge states from 1{sup +} to 4{sup +}. The acoustic amplitude dependence on the ion beam parameters like the ion mass and energy, the ion charge state, the beam spot size and the pulse duration were of interest. This work deals with ultrasound transmitted in a solid, i.e. bulk waves, because of their importance for acoustic transmission microscopy and nondestructive inspection of internal structure of a sample. The second part of this work was carried out using the IMSA-100 FIB system operating in an energy range from 30 to 70 keV. The scanning ion acoustic microscope based on this FIB system was developed and tested. (orig.)

  16. Development and characterization of a 2D scintillation detector for quality assurance in scanned carbon ion beams

    Science.gov (United States)

    Tamborini, A.; Raffaele, L.; Mirandola, A.; Molinelli, S.; Viviani, C.; Spampinato, S.; Ciocca, M.

    2016-04-01

    At the Centro Nazionale di Adroterapia Oncologica (CNAO Foundation), a two-dimensional high resolution scintillating dosimetry system has been developed and tested for daily Quality Assurance measurements (QA) in carbon ion radiotherapy with active scanning technique, for both single pencil beams and scanned fields produced by a synchrotron accelerator. The detector consists of a thin plane organic scintillator (25×25 cm2, 2 mm thick) coupled with a high spatial resolution CCD camera (0.25 mm) in a light-tight box. A dedicated Labview software was developed for image acquisition triggered with the beam extraction, data post-processing and analysis. The scintillator system was preliminary characterized in terms of short-term reproducibility (found to be within±0.5%), linearity with the number of particles (linear fit χ2 = 0.996) and dependence on particle flux (measured to be < 1.5 %). The detector was then tested for single beam spot measurements (Full Width at Half Maximum and position) and for 6×6 cm2 reference scanned field (determination of homogeneity) for carbon ions with energy from 115 MeV/u up to 400 MeV/u. No major differences in the investigated beam parameters measured with scintillator system and the radiochromic EBT3 reference films were observed. The system allows therefore real-time monitoring of the carbon ion beam relevant parameters, with a significant daily time saving with respect to films currently used. The results of this study show the suitability of the scintillation detector for daily QA in a carbon ion facility with an active beam delivery system.

  17. Motion compensation with a scanned ion beam: a technical feasibility study

    International Nuclear Information System (INIS)

    Intrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target motion by tracking with the treatment beam. Lateral motion components were compensated directly with the beam scanning system by adapting nominal beam positions according to the target motion. Longitudinal motion compensation to mitigate motion induced range changes was performed with a dedicated wedge system that adjusts effective particle energies at isocenter. Lateral compensation performance was better than 1% for a homogeneous dose distribution when comparing irradiations of a stationary radiographic film and a moving film using motion compensation. The accuracy of longitudinal range compensation was well below 1 mm. Motion compensation with scanned particle beams is technically feasible with high precision

  18. Exponential Tracking Control Using Backstepping Approach for Voltage-Based Control of a Flexible Joint Electrically Driven Robot

    Directory of Open Access Journals (Sweden)

    Jean Bosco Mbede

    2014-01-01

    Full Text Available This paper addresses the design of exponential tracking control using backstepping approach for voltage-based control of a flexible joint electrically driven robot (EFJR, to cope with the difficulty introduced by the cascade structure in EFJR dynamic model, to deal with flexibility in joints, and to ensure fast tracking performance. Backstepping approach is used to ensure global asymptotic stability and its common algorithm is modified such that the link position and velocity errors converge to zero exponentially fast. In contrast with the other backstepping controller for electrically driven flexible joint robot manipulators control problem, the proposed controller is robust with respect to stiffness uncertainty and allows tracking fast motions. Simulation results are presented for both single link flexible joint electrically driven manipulator and 2-DOF flexible joint electrically driven robot manipulator. These simulations show very satisfactory tracking performances and the superiority of the proposed controller to those performed in the literature using simple backstepping methodology.

  19. Optimized treatment parameters to account for interfractional variability in scanned ion beam therapy of lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Brevet, Romain

    2015-02-04

    Scanned ion beam therapy of lung tumors is severely limited in its clinical applicability by intrafractional organ motion, interference effects between beam and tumor motion (interplay) as well as interfractional anatomic changes. To compensate for dose deterioration by intrafractional motion, motion mitigation techniques, such as gating have been developed. The latter confines the irradiation to a predetermined breathing state, usually the stable end-exhale phase. However, optimization of the treatment parameters is needed to further improve target dose coverage and normal tissue sparing. The aim of the study presented in this dissertation was to determine treatment planning parameters that permit to recover good target coverage and homogeneity during a full course of lung tumor treatments. For 9 lung tumor patients from MD Anderson Cancer Center (MDACC), a total of 70 weekly time-resolved computed tomography (4DCT) datasets were available, which depict the evolution of the patient anatomy over the several fractions of the treatment. Using the GSI in-house treatment planning system (TPS) TRiP4D, 4D simulations were performed on each weekly 4DCT for each patient using gating and optimization of a single treatment plan based on a planning CT acquired prior to treatment. It was found that using a large beam spot size, a short gating window (GW), additional margins and multiple fields permitted to obtain the best results, yielding an average target coverage (V95) of 96.5%. Two motion mitigation techniques, one approximating the rescanning process (multiple irradiations of the target with a fraction of the planned dose) and one combining the latter and gating, were then compared to gating. Both did neither show an improvement in target dose coverage nor in normal tissue sparing. Finally, the total dose delivered to each patient in a simulation of a fractioned treatment was calculated and clinical requirements in terms of target coverage and normal tissue sparing were

  20. Speed and accuracy of a beam tracking system for treatment of moving targets with scanned ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Saito, Nami; Bert, Christoph; Chaudhri, Naved; Gemmel, Alexander; Schardt, Dieter; Durante, Marco; Rietzel, Eike [GSI Helmholtz Centre for Heavy Ion Research GmbH, Planckstrasse 1, 64291 Darmstadt (Germany)], E-mail: n.saito@gsi.de

    2009-08-21

    The technical performance of an integrated three-dimensional carbon ion pencil beam tracking system that was developed at GSI was investigated in phantom studies. Aim of the beam tracking system is to accurately treat tumours that are subject to respiratory motion with scanned ion beams. The current system provides real-time control of ion pencil beams to track a moving target laterally using the scanning magnets and longitudinally with a dedicated range shifter. The system response time was deduced to be approximately 1 ms for lateral beam tracking. The range shifter response time has been measured for various range shift amounts. A value of 16 {+-} 2 ms was achieved for a water equivalent shift of 5 mm. An additional communication delay of 11 {+-} 2 ms was taken into account in the beam tracking process via motion prediction. Accuracy of the lateral beam tracking was measured with a multi-wire position detector to {<=}0.16 mm standard deviation. Longitudinal beam tracking accuracy was parameterized based on measured responses of the range shifter and required time durations to maintain a specific particle range. For example, 5 mm water equivalence (WE) longitudinal beam tracking results in accuracy of 1.08 and 0.48 mm WE in root mean square for time windows of 10 and 50 ms, respectively.

  1. Analysis of tyrosine phosphorylation sites in signaling molecules by a phosphotyrosine-specific immonium ion scanning method

    DEFF Research Database (Denmark)

    Steen, Hanno; Pandey, Akhilesh; Andersen, Jens S;

    2002-01-01

    Signal transduction pathways involve cascades of events, such as formation of second messengers and protein complexes that alter the activities of proteins. This can ultimately lead to changes in gene expression in response to the stimuli. Reversible phosphorylation of proteins is an important me...... mechanism for activating or inhibiting enzymes and for the assembly of multiprotein complexes. Here, we describe a mass spectrometry-based phosphotyrosine-specific immonium ion scanning (PSI scanning) method for selective detection of tyrosine-phosphorylated peptides. Once the tyrosine......-phosphorylated peptides are identified, they can be directly sequenced in the same experiment to localize the phosphorylation site. We provide protocols for isolation and preparation of samples for analysis, and detailed instructions for operation of a quadrupole time-of-flight (TOF) mass spectrometer for this method...

  2. Bioinspired Protein Channel-Based Scanning Ion Conductance Microscopy (Bio-SICM) for Simultaneous Conductance and Specific Molecular Imaging.

    Science.gov (United States)

    Macazo, Florika C; White, Ryan J

    2016-03-01

    The utility of stochastic single-molecule detection using protein nanopores has found widespread application in bioanalytical sensing as a result of the inherent signal amplification of the resistive pulse method. Integration of protein nanopores with high-resolution scanning ion conductance microscopy (SICM) extends the utility of SICM by enabling selective chemical imaging of specific target molecules, while simultaneously providing topographical information about the net ion flux through a pore under a concentration gradient. In this study, we describe the development of a bioinspired scanning ion conductance microscopy (bio-SICM) approach that couples the imaging ability of SICM with the sensitivity and chemical selectivity of protein channels to perform simultaneous pore imaging and specific molecule mapping. To establish the framework of the bio-SICM platform, we utilize the well-studied protein channel α-hemolysin (αHL) to map the presence of β-cyclodextrin (βCD) at a substrate pore opening. We demonstrate concurrent pore and specific molecule imaging by raster scanning an αHL-based probe over a glass membrane containing a single 25-μm-diameter glass pore while recording the lateral positions of the probe and channel activity via ionic current. We use the average channel current to create a conductance image and the raw current-time traces to determine spatial localization of βCD. With further optimization, we believe that the bio-SICM platform will provide a powerful analytical methodology that is generalizable, and thus offers significant utility in a myriad of bioanalytical applications. PMID:26848947

  3. Advantages of scanning-mode ion beam analysis for the study of Cultural Heritage

    Science.gov (United States)

    Grassi, N.; Giuntini, L.; Mandò, P. A.; Massi, M.

    2007-03-01

    In this paper, we discuss the convenience of performing external PIXE and PIGE measurements by scanning relatively large areas (some mm2) with a beam size of the order of hundred microns, rather than performing "spot" compositional analysis. Examples of test runs on samples of archaeometric interest are presented: scanning-mode measurements of ancient inks, Roman glass and metal point drawings clearly demonstrate that using this procedure to perform IBA may become fundamental to avoid deceptive information and to obtain more reliable quantitative results.

  4. Recent developments of ion beam induced luminescence at the external scanning microbeam facility of the LABEC laboratory in Florence

    Science.gov (United States)

    Colombo, E.; Calusi, S.; Cossio, R.; Giuntini, L.; Giudice, A. Lo; Mandò, P. A.; Manfredotti, C.; Massi, M.; Mirto, F. A.; Vittone, E.

    2008-04-01

    A new ionoluminescence (IL) apparatus has been successfully installed at the external scanning microbeam facility of the 3 MV Tandetron accelerator of the INFN LABEC in Firenze; the apparatus for photon detection has been fully integrated in the existing ion beam analysis (IBA) set-up, for the simultaneous acquisition of IL and PIXE/PIGE/BS spectra and maps. The potential of the new set-up is illustrated in this paper by some results extracted by the analysis of art objects and advanced semiconductor materials. In particular, the adequacy of the new IBA set-up in the field of cultural heritage is pointed out by the coupled PIXE/IL micro-analysis of a lapis lazuli stone; concerning applications in material science, IL spectra from a N doped diamond sample were acquired and compared with CL analyses to evaluate the relevant sensitivities and the effect of ion damage.

  5. Stripping chronopotentiometry at scanned deposition potential (SSCP). Part 2. Determination of metal ion speciation parameters

    NARCIS (Netherlands)

    Leeuwen, van H.P.; Town, R.M.

    2003-01-01

    Stripping chronopotentiometry at scanned deposition potential (SSCP) generates curves that are fundamentally different in form from classical polarographic waves. Still, despite their steeper slope and non-linear log plot, the shift in the SSCP half-wave deposition potential can be interpreted in a

  6. Adaptive Backstepping controller design and implementation for a matrix-converter-based IM drive system

    Directory of Open Access Journals (Sweden)

    R.R. Joshi

    2007-06-01

    Full Text Available A systematic controller design and implementation for a matrix-converter-based induction motor drive system is proposed. A nonlinear adaptive backstepping controller is proposed to improve the speed and position responses of the induction motor system. By using the proposed adaptive backstepping controller, the system can track a time-varying speed command and a time-varying position command well. Moreover, the system has a good load disturbance rejection capability. The realization of the controller is very simple. All of the control loops, including the current loop, speed loop and position loop, are implemented by a digital signal processor. Several experimental results are given to validate the theoretical analysis.

  7. Dynamical Adaptive Integral Sliding Backstepping Control of Nonlinear Nontriangular Uncertain Systems

    Directory of Open Access Journals (Sweden)

    Mahmood Pervaiz

    2014-01-01

    Full Text Available We present a control strategy for nonlinear nontriangular uncertain systems. The proposed control method is a synergy between the dynamic adaptive backstepping (DAB and integral sliding mode (ISM and is referred to as DAB-ISMC. Our main objective is to find a recursive procedure to transform a nontriangular system into an implementable form that enables designing a control law which almost eliminates the reaching-phase. The proposed method further facilitates minimization of chattering which is believed to be a shortcoming of the sliding mode control. In this methodology, the ISM, as an integrated subsystem of DAB, is introduced at the final stage of backstepping. This strategy works very well to obtain a system that is robust against model imperfections, matching and unmatching uncertainties. The DAB-ISMC method is applied on a continuous stirred tank reactor (CSTR and simulation results obtained on Matlab are found to be very promising.

  8. Design of a nonlinear backstepping control strategy of grid interconnected wind power system based PMSG

    Science.gov (United States)

    Errami, Y.; Obbadi, A.; Sahnoun, S.; Benhmida, M.; Ouassaid, M.; Maaroufi, M.

    2016-07-01

    This paper presents nonlinear backstepping control for Wind Power Generation System (WPGS) based Permanent Magnet Synchronous Generator (PMSG) and connected to utility grid. The block diagram of the WPGS with PMSG and the grid side back-to-back converter is established with the dq frame of axes. This control scheme emphasises the regulation of the dc-link voltage and the control of the power factor at changing wind speed. Besides, in the proposed control strategy of WPGS, Maximum Power Point Tracking (MPPT) technique and pitch control are provided. The stability of the regulators is assured by employing Lyapunov analysis. The proposed control strategy for the system has been validated by MATLAB simulations under varying wind velocity and the grid fault condition. In addition, a comparison of simulation results based on the proposed Backstepping strategy and conventional Vector Control is provided.

  9. Novel backstepping design for blended aero and reaction-jet missile autopilot

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The advanced missile uses blended control of aero-fin and reaction-jet to improve missile maneuverability.The blended control design,which is multi-inputs and multi-outputs (MIMO),severe nonlinear,and model uncertain,is much more complex than conventional aero-fin control.A novel nonlinear backstepping control approach is proposed to design the blended autopilot.Missile model is reformed to a new one by state reconstruction technique so that it is easy to be handled by the backetepping method.Then a Lyapunov function is chosen to avoid oscillation caused in normal backstepping way when control parameters are mismatched.In distribution of both inputs,optimal energy logic is proposed.In addition,a fuzzy cerebellar model articulation controller (FCMAC)neural network is used to guarantee controller robustness to uncertainties.Finally,simulation results demonstrate the efficiency and advantages of the proposed method.

  10. Aircraft-on-ground path following control by dynamical adaptive backstepping

    Institute of Scientific and Technical Information of China (English)

    Chen Bihua; Jiao Zongxia; Shuzhi Sam Ge

    2013-01-01

    The necessity of improving the air traffic and reducing the aviation emissions drives to investigate automatic steering for aircraft to effectively roll on the ground.This paper addresses the path following control problem of aircraft-on-ground and focuses on the task that the aircraft is required to follow the desired path on the runway by nose wheel automatic steering.The proposed approach is based on dynamical adaptive backstepping so that the system model does not have to be transformed into a canonical triangular form which is necessary in conventional backstepping design.This adaptive controller performs well despite the lack of information on the aerodynamic load and the tire cornering stiffness parameters.Simulation results clearly demonstrate the advantages and effectiveness of the proposed approach.

  11. Robust Backstepping Control Based on a Lyapunov Redesign for Skid-Steered Wheeled Mobile Robots

    Directory of Open Access Journals (Sweden)

    Eun-Ju Hwang

    2013-01-01

    Full Text Available This paper represents a robust backstepping tracking control based on a Lyapunov redesign for Skid‐Steered Wheeled Mobile Robots (WMRs. We present kinematic and dynamic models that explicitly relate the perturbations to the skidding in order to improve the tracking performance during real running. A robust controller is synthesized in the backstepping approach and the Lyapunov redesign technique, which forces the error dynamics to stabilize to the reference trajectories. We design an additional feedback control ‐ a Lyapunov redesign ‐ such that the overall control stabilizes the actual system in the presence of uncertainty and perturbation with the knowledge of the Lyapunov function. Simulation results are provided to validate and analyse the performance and stability of the proposed controller.

  12. Recurrent fuzzy neural network backstepping control for the prescribed output tracking performance of nonlinear dynamic systems.

    Science.gov (United States)

    Han, Seong-Ik; Lee, Jang-Myung

    2014-01-01

    This paper proposes a backstepping control system that uses a tracking error constraint and recurrent fuzzy neural networks (RFNNs) to achieve a prescribed tracking performance for a strict-feedback nonlinear dynamic system. A new constraint variable was defined to generate the virtual control that forces the tracking error to fall within prescribed boundaries. An adaptive RFNN was also used to obtain the required improvement on the approximation performances in order to avoid calculating the explosive number of terms generated by the recursive steps of traditional backstepping control. The boundedness and convergence of the closed-loop system was confirmed based on the Lyapunov stability theory. The prescribed performance of the proposed control scheme was validated by using it to control the prescribed error of a nonlinear system and a robot manipulator.

  13. Path Following of an Underactuated AUV Based on Fuzzy Backstepping Sliding Mode Control

    Directory of Open Access Journals (Sweden)

    Xiao Liang

    2016-06-01

    Full Text Available This paper addresses the path following problem of an underactuated autonomous underwater vehicle (AUV with the aim of dealing with parameter uncertainties and current disturbances. An adaptive robust control system was proposed by employing fuzzy logic, backstepping and sliding mode control theory. Fuzzy logic theory is adopted to approximate unknown system function, and the controller was designed by combining sliding mode control with backstepping thought. Firstly, the longitudinal speed was controlled, then the yaw angle was made as input of path following error to design the calm function and the change rate of path parameters. The controller stability was proved by Lyapunov stable theory. Simulation and outfield tests were conducted and the results showed that the controller is of excellent adaptability and robustness in the presence of parameter uncertainties and external disturbances. It is also shown to be able to avoid the chattering of AUV actuators.

  14. Command Filtered Adaptive Fuzzy Neural Network Backstepping Control for Marine Power System

    Directory of Open Access Journals (Sweden)

    Xin Zhang

    2014-01-01

    Full Text Available In order to retrain chaotic oscillation of marine power system which is excited by periodic electromagnetism perturbation, a novel command-filtered adaptive fuzzy neural network backstepping control method is designed. First, the mathematical model of marine power system is established based on the two parallel nonlinear model. Then, main results of command-filtered adaptive fuzzy neural network backstepping control law are given. And the Lyapunov stability theory is applied to prove that the system can remain closed-loop asymptotically stable with this controller. Finally, simulation results indicate that the designed controller can suppress chaotic oscillation with fast convergence speed that makes the system return to the equilibrium point quickly; meanwhile, the parameter which induces chaotic oscillation can also be discriminated.

  15. Backstepping design of a Nonlinear Observer for the Rotor Field of an Induction Motor

    DEFF Research Database (Denmark)

    Rasmussen, Henrik

    2000-01-01

    Using backstepping, which is a recursive nonlinear design method, a new approach for the design of flux observers is developed. The resulting scheme leads to a nonlinear full order observer for the amplitude and angle of the field. Assuming motor parameters known the design achieves stability...... with guaranteed region of attraction. Rubustness due to variation of motor parameters is analysed by simulation. The result is compared to the flux estimate used in a conventional field oriented controller Using backstepping, which is a recursive nonlinear design method, a new approach for the design of flux...... observers is developed. The resulting scheme leads to a nonlinear full order observer for the amplitude and angle of the field. Assuming motor parameters known the design achieves stability with guaranteed region of attraction. Rubustness due to variation of motor parameters is analysed by simulation...

  16. Sampled-Data Backstepping Control of a Quadrotor Unmanned Aerial Vehicle

    Directory of Open Access Journals (Sweden)

    Abdul Jabbar

    2014-12-01

    Full Text Available Sampled-data backstepping control of a quadrotor UAV is presented in this paper. The discrete time controllers have been designed on the basis of a continuous time system model and an approximate discrete time equivalent system model (Euler Approximate model obtained using the Euler method. The performance of the controllers obtained using the two sampled-data approaches has been compared in the presence of wing gusts and modeling uncertainties. Simulations have revealed that the backstepping controller designed on the basis of an approximate discrete time model has better performance in the presence of wind gusts and modeling uncertainties. In addition, the closed loop system has a larger region of attraction.

  17. Station-keeping control for a stratospheric airship platform via fuzzy adaptive backstepping approach

    Science.gov (United States)

    Yang, Yueneng; Wu, Jie; Zheng, Wei

    2013-04-01

    This paper presents a novel approach for station-keeping control of a stratospheric airship platform in the presence of parametric uncertainty and external disturbance. First, conceptual design of the stratospheric airship platform is introduced, including the target mission, configuration, energy sources, propeller and payload. Second, the dynamics model of the airship platform is presented, and the mathematical model of its horizontal motion is derived. Third, a fuzzy adaptive backstepping control approach is proposed to develop the station-keeping control system for the simplified horizontal motion. The backstepping controller is designed assuming that the airship model is accurately known, and a fuzzy adaptive algorithm is used to approximate the uncertainty of the airship model. The stability of the closed-loop control system is proven via the Lyapunov theorem. Finally, simulation results illustrate the effectiveness and robustness of the proposed control approach.

  18. Robust adaptive backstepping neural networks control for spacecraft rendezvous and docking with input saturation.

    Science.gov (United States)

    Xia, Kewei; Huo, Wei

    2016-05-01

    This paper presents a robust adaptive neural networks control strategy for spacecraft rendezvous and docking with the coupled position and attitude dynamics under input saturation. Backstepping technique is applied to design a relative attitude controller and a relative position controller, respectively. The dynamics uncertainties are approximated by radial basis function neural networks (RBFNNs). A novel switching controller consists of an adaptive neural networks controller dominating in its active region combined with an extra robust controller to avoid invalidation of the RBFNNs destroying stability of the system outside the neural active region. An auxiliary signal is introduced to compensate the input saturation with anti-windup technique, and a command filter is employed to approximate derivative of the virtual control in the backstepping procedure. Globally uniformly ultimately bounded of the relative states is proved via Lyapunov theory. Simulation example demonstrates effectiveness of the proposed control scheme.

  19. Adaptive backstepping control and synchronization of a modified and chaotic Van der Pol-Duffing oscillator

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In this paper,we propose a backstepping approach for the synchronization and control of modified Van-der Pol Duffing oscillator circuits.The method is such that one controller function that depends essentially on available circuit parameters that is sufficient to drive the two coupled circuits to a synchronized state as well achieve the global stabilization of the system to its regular dynamics.Numerical simulations are given to demonstrate the effectiveness of the technique.

  20. Backstepping design of missile guidance and control based on adaptive fuzzy sliding mode control

    OpenAIRE

    Ran Maopeng; Wang Qing; Hou Delong; Dong Chaoyang

    2014-01-01

    This paper presents an integrated missile guidance and control law based on adaptive fuzzy sliding mode control. The integrated model is formulated as a block-strict-feedback nonlinear system, in which modeling errors, unmodeled nonlinearities, target maneuvers, etc. are viewed as unknown uncertainties. The adaptive nonlinear control law is designed based on backstepping and sliding mode control techniques. An adaptive fuzzy system is adopted to approximate the coupling nonlinear functions of...

  1. DESIGN AND OPTIMIZATION OF BACKSTEPPING CONTROLLER FOR AN UNDERACTUATED AUTONOMOUS QUADROTOR UNMANNED AERIAL VEHICLE

    OpenAIRE

    Mohd Basri, Mohd Ariffanan; Danapalasingam, Kumeresan A.; Husain, Abdul Rashid

    2014-01-01

    The development of a high performance controller for a quadrotor unmanned aerial vehicle (UAV) is a challenging issue since a quadrotor is an underactuated and a highly unstable nonlinear system. In this paper, the contribution is focused on the design and optimization of a controller for an autonomous quadrotor UAV. Firstly, the dynamic model of the aerial vehicle is mathematically formulated. Then, an optimal backstepping controller (OBC) is proposed. Conventionally, control parameters of a...

  2. Backstepping Synthesis for Feedback Control of First-Order Hyperbolic PDEs with Spatial-Temporal Actuation

    Directory of Open Access Journals (Sweden)

    Xin Yu

    2014-01-01

    Full Text Available This paper deals with the stabilization problem of first-order hyperbolic partial differential equations (PDEs with spatial-temporal actuation over the full physical domains. We assume that the interior actuator can be decomposed into a product of spatial and temporal components, where the spatial component satisfies a specific ordinary differential equation (ODE. A Volterra integral transformation is used to convert the original system into a simple target system using the backstepping-like procedure. Unlike the classical backstepping techniques for boundary control problems of PDEs, the internal actuation can not eliminate the residual term that causes the instability of the open-loop system. Thus, an additional differential transformation is introduced to transfer the input from the interior of the domain onto the boundary. Then, a feedback control law is designed using the classic backstepping technique which can stabilize the first-order hyperbolic PDE system in a finite time, which can be proved by using the semigroup arguments. The effectiveness of the design is illustrated with some numerical simulations.

  3. Backstepping fuzzy-neural-network control design for hybrid maglev transportation system.

    Science.gov (United States)

    Wai, Rong-Jong; Yao, Jing-Xiang; Lee, Jeng-Dao

    2015-02-01

    This paper focuses on the design of a backstepping fuzzy-neural-network control (BFNNC) for the online levitated balancing and propulsive positioning of a hybrid magnetic levitation (maglev) transportation system. The dynamic model of the hybrid maglev transportation system including levitated hybrid electromagnets to reduce the suspension power loss and the friction force during linear movement and a propulsive linear induction motor based on the concepts of mechanical geometry and motion dynamics is first constructed. The ultimate goal is to design an online fuzzy neural network (FNN) control methodology to cope with the problem of the complicated control transformation and the chattering control effort in backstepping control (BSC) design, and to directly ensure the stability of the controlled system without the requirement of strict constraints, detailed system information, and auxiliary compensated controllers despite the existence of uncertainties. In the proposed BFNNC scheme, an FNN control is utilized to be the major control role by imitating the BSC strategy, and adaptation laws for network parameters are derived in the sense of projection algorithm and Lyapunov stability theorem to ensure the network convergence as well as stable control performance. The effectiveness of the proposed control strategy for the hybrid maglev transportation system is verified by experimental results, and the superiority of the BFNNC scheme is indicated in comparison with the BSC strategy and the backstepping particle-swarm-optimization control system in previous research. PMID:25608292

  4. Adaptive Backstepping Sliding-Mode Control of the Electronic Throttle System in Modern Automobiles

    Directory of Open Access Journals (Sweden)

    Rui Bai

    2014-01-01

    Full Text Available In modern automobiles, electronic throttle is a DC-motor-driven valve that regulates air inflow into the vehicle’s combustion system. The electronic throttle is increasingly being used in order to improve the vehicle drivability, fuel economy, and emissions. Electronic throttle system has the nonlinear dynamical characteristics with the unknown disturbance and parameters. At first, the dynamical nonlinear model of the electronic throttle is built in this paper. Based on the model and using the backstepping design technique, a new adaptive backstepping sliding-mode controller of the electronic throttle is developed. During the backstepping design process, parameter adaptive law is designed to estimate the unknown parameter, and sliding-mode control term is applied to compensate the unknown disturbance. The proposed controller can make the actual angle of the electronic throttle track its set point with the satisfactory performance. Finally, a computer simulation is performed, and simulation results verify that the proposed control method can achieve favorable tracking performance.

  5. Dimensional comparison between amplitude-modulation atomic force microscopy and scanning ion conductance microscopy of biological samples

    Science.gov (United States)

    Kim, Joonhui; Choi, MyungHoon; Jung, Goo-Eun; Rahim Ferhan, Abdul; Cho, Nam-Joon; Cho, Sang-Joon

    2016-08-01

    The range of scanning probe microscopy (SPM) applications for atomic force microscopy (AFM) is expanding in the biological sciences field, reflecting an increasing demand for tools that can improve our fundamental understanding of the physics behind biological systems. However, the complexity associated with applying SPM techniques in biomedical research hampers the full exploitation of its capabilities. Recently, the development of scanning ion conductance microscopy (SICM) has overcome these limitations and enabled contact-free, high resolution imaging of live biological specimens. In this work, we demonstrate the limitation of AFM for imaging biological samples in liquid due to artifacts arising from AFM tip-sample interaction, and how SICM imaging is able to overcome those limitations with contact-free scanning. We also demonstrate that SICM measurements, when compared to AFM, show better fit to the actual dimensions of the biological samples. Our results highlight the superiority of SICM imaging, enabling it to be widely adopted as a general and versatile research tool for biological studies in the nanoscale.

  6. Dimensional comparison between amplitude-modulation atomic force microscopy and scanning ion conductance microscopy of biological samples

    Science.gov (United States)

    Kim, Joonhui; Choi, MyungHoon; Jung, Goo-Eun; Rahim Ferhan, Abdul; Cho, Nam-Joon; Cho, Sang-Joon

    2016-08-01

    The range of scanning probe microscopy (SPM) applications for atomic force microscopy (AFM) is expanding in the biological sciences field, reflecting an increasing demand for tools that can improve our fundamental understanding of the physics behind biological systems. However, the complexity associated with applying SPM techniques in biomedical research hampers the full exploitation of its capabilities. Recently, the development of scanning ion conductance microscopy (SICM) has overcome these limitations and enabled contact-free, high resolution imaging of live biological specimens. In this work, we demonstrate the limitation of AFM for imaging biological samples in liquid due to artifacts arising from AFM tip–sample interaction, and how SICM imaging is able to overcome those limitations with contact-free scanning. We also demonstrate that SICM measurements, when compared to AFM, show better fit to the actual dimensions of the biological samples. Our results highlight the superiority of SICM imaging, enabling it to be widely adopted as a general and versatile research tool for biological studies in the nanoscale.

  7. In situ ion etching in a scanning electron microscope and its application to the study of dental restorations

    International Nuclear Information System (INIS)

    The cylindrical version of the Saddle Field ion source has been water-cooled to eliminate radiation from the source which contributes to the rise in temperature of a specimen undergoing ion bombardment. This has also eliminated the problem of the build-up of black contamination on the anodes which causes a deterioration in the performance within the first hour of operation. In the water-cooled source, smooth conducting films are obtained instead of the black uneven deposit, and this gives extremely stable operation for long periods of time. One of these sources has been incorporated into the specimen stage of a scanning electron microscope to provide a facility for the in situ ion etching of all types of materials. A particular problem of the recurrent failure of dental fillings has been studied in some detail and it is believed that this may be due to a thin bridge of amalgam near the interface with the enamel which is removed during etching, exposing a relatively large gap immediately below. A similar process may occur in the oral environment, where this thin layer can be fractured due to mastication, enabling bacteria to penetrate and thus initiate decay. Work is also being carried out in vivo using replication techniques to try to substantiate these findings. (author)

  8. Identified particle production and freeze-out properties in heavy-ion collisions at RHIC Beam Energy Scan program

    CERN Document Server

    ,

    2014-01-01

    The first phase of Beam Energy Scan (BES) program at the Relativistic Heavy-Ion Collider (RHIC) was started in the year 2010 with the aim to study the several aspects of the quantum chromodynamics (QCD) phase diagram. The Solenoidal Tracker At RHIC (STAR) detector has taken data at $\\sqrt{s_{NN}} = $ 7.7, 11.5, 19.6, 27, and 39 GeV in Au+Au collisions in the years 2010 and 2011 as part of the BES programme. For these beam energies, we present the results on the particle yields, average transverse mass and particle ratios for identified particles in mid-rapidity ($|y|$ < 0.1). The measured particle ratios have been used to study the chemical freeze-out dynamics within the framework of a statistical model.

  9. Identified particle production and freeze-out properties in heavy-ion collisions at RHIC Beam Energy Scan program

    Directory of Open Access Journals (Sweden)

    Das Sabita

    2015-01-01

    Full Text Available The first phase of Beam Energy Scan (BES program at the Relativistic Heavy-Ion Collider (RHIC was started in the year 2010 with the aim to study the several aspects of the quantum chromodynamics (QCD phase diagram. The Solenoidal Tracker At RHIC (STAR detector has taken data at √sNN = 7.7, 11.5, 19.6, 27, and 39 GeV in Au+Au collisions in the years 2010 and 2011 as part of the BES programme. For these beam energies, we present the results on the particle yields, average transverse mass and particle ratios for identified particles in mid-rapidity (|y| < 0.1. The measured particle ratios have been used to study the chemical freezeout dynamics within the framework of a statistical model.

  10. Comparison of SOFC Cathode Microstructure Quantified using X-ray Nanotomography and Focused Ion Beam - Scanning Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, George J. [Univ. of Connecticut, Storrs, CT (United States); Harris, William H. [Univ. of Connecticut, Storrs, CT (United States); Lombardo, Jeffrey J. [Univ. of Connecticut, Storrs, CT (United States); Izzo, Jr., John R. [Univ. of Connecticut, Storrs, CT (United States); Chiu, W. K. S. [Univ. of Connecticut, Storrs, CT (United States); Tanasini, Pietro [Ecole Ploytechnique Federale de Lausanne (Switzerland); Cantoni, Marco [Ecole Ploytechnique Federale de Lausanne (Switzerland); Van herle, Jan [Ecole Ploytechnique Federale de Lausanne (Switzerland); Comninellis, Christos [Ecole Ploytechnique Federale de Lausanne (Switzerland); Andrews, Joy C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Liu, Yijin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Pianetta, Piero [SLAC National Accelerator Lab., Menlo Park, CA (United States); Chu, Yong [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2011-03-24

    X-ray nanotomography and focused ion beam scanning electron microscopy (FIB-SEM) have been applied to investigate the complex 3D microstructure of solid oxide fuel cell (SOFC) electrodes at spatial resolutions of 45 nm and below. The application of near edge differential absorption for x-ray nanotomography and energy selected backscatter detection for FIB–SEM enable elemental mapping within the microstructure. Using these methods, non-destructive 3D x-ray imaging and FIB–SEM serial sectioning have been applied to compare three-dimensional elemental mapping of the LSM, YSZ, and pore phases in the SOFC cathode microstructure. The microstructural characterization of an SOFC cathode is reported based on these measurements. The results presented demonstrate the viability of x-ray nanotomography as a quantitative characterization technique and provide key insights into the SOFC cathode microstructure.

  11. Characterization of nanometer-scale porosity in reservoir carbonate rock by focused ion beam-scanning electron microscopy.

    Science.gov (United States)

    Bera, Bijoyendra; Gunda, Naga Siva Kumar; Mitra, Sushanta K; Vick, Douglas

    2012-02-01

    Sedimentary carbonate rocks are one of the principal porous structures in natural reservoirs of hydrocarbons such as crude oil and natural gas. Efficient hydrocarbon recovery requires an understanding of the carbonate pore structure, but the nature of sedimentary carbonate rock formation and the toughness of the material make proper analysis difficult. In this study, a novel preparation method was used on a dolomitic carbonate sample, and selected regions were then serially sectioned and imaged by focused ion beam-scanning electron microscopy. The resulting series of images were used to construct detailed three-dimensional representations of the microscopic pore spaces and analyze them quantitatively. We show for the first time the presence of nanometer-scale pores (50-300 nm) inside the solid dolomite matrix. We also show the degree of connectivity of these pores with micron-scale pores (2-5 μm) that were observed to further link with bulk pores outside the matrix.

  12. Recent experimental studies of ion acceleration driven by intense laser radiation pressure - Parametric scan and energy scaling

    International Nuclear Information System (INIS)

    Radiation Pressure Acceleration (RPA) mechanism is currently attracting a substantial amount of experimental and theoretical attention worldwide. Employing the Petawatt laser of the Rutherford Appleton Laboratory, UK, both the Hole-boring (HB) and Light sail (LS) regimes of RPA have been extensively explored by scanning over wide range of laser and target parameters. The dominant role of laser radiation pressure in such intense interaction conditions resulted in narrow band heavy ion spectra, where the ion energy scales with [Iτ/ξ)15 (I, τ and ξ stand for laser intensity, pulse duration and target areal density respectively] - significantly faster than the competing 'Target Normal Sheath Acceleration' mechanism (E oc I0.5). The aftermath of RPA is observed in the late time (0.1 -1 ns) evolution of collimated plasma jets ejected from the target rear surface, detected by ps time resolved transverse interferometry. Significant Improvement in spatial uniformity of the plasma jet density profile observed for circularly polarised laser compared to linear, polarisation is a clear indicative of the role played by circular polarisation towards stability of the RPA. (author)

  13. Combining operando synchrotron X-ray tomographic microscopy and scanning X-ray diffraction to study lithium ion batteries.

    Science.gov (United States)

    Pietsch, Patrick; Hess, Michael; Ludwig, Wolfgang; Eller, Jens; Wood, Vanessa

    2016-01-01

    We present an operando study of a lithium ion battery combining scanning X-ray diffraction (SXRD) and synchrotron radiation X-ray tomographic microscopy (SRXTM) simultaneously for the first time. This combination of techniques facilitates the investigation of dynamic processes in lithium ion batteries containing amorphous and/or weakly attenuating active materials. While amorphous materials pose a challenge for diffraction techniques, weakly attenuating material systems pose a challenge for attenuation-contrast tomography. Furthermore, combining SXRD and SRXTM can be used to correlate processes occurring at the atomic level in the crystal lattices of the active materials with those at the scale of electrode microstructure. To demonstrate the benefits of this approach, we investigate a silicon powder electrode in lithium metal half-cell configuration. Combining SXRD and SRXTM, we are able to (i) quantify the dissolution of the metallic lithium electrode and the expansion of the silicon electrode, (ii) better understand the formation of the Li15Si4 phase, and (iii) non-invasively probe kinetic limitations within the silicon electrode. A simple model based on the 1D diffusion equation allows us to qualitatively understand the observed kinetics and demonstrates why high-capacity electrodes are more prone to inhomogeneous lithiation reactions. PMID:27324109

  14. Combining operando synchrotron X-ray tomographic microscopy and scanning X-ray diffraction to study lithium ion batteries

    Science.gov (United States)

    Pietsch, Patrick; Hess, Michael; Ludwig, Wolfgang; Eller, Jens; Wood, Vanessa

    2016-01-01

    We present an operando study of a lithium ion battery combining scanning X-ray diffraction (SXRD) and synchrotron radiation X-ray tomographic microscopy (SRXTM) simultaneously for the first time. This combination of techniques facilitates the investigation of dynamic processes in lithium ion batteries containing amorphous and/or weakly attenuating active materials. While amorphous materials pose a challenge for diffraction techniques, weakly attenuating material systems pose a challenge for attenuation-contrast tomography. Furthermore, combining SXRD and SRXTM can be used to correlate processes occurring at the atomic level in the crystal lattices of the active materials with those at the scale of electrode microstructure. To demonstrate the benefits of this approach, we investigate a silicon powder electrode in lithium metal half-cell configuration. Combining SXRD and SRXTM, we are able to (i) quantify the dissolution of the metallic lithium electrode and the expansion of the silicon electrode, (ii) better understand the formation of the Li15Si4 phase, and (iii) non-invasively probe kinetic limitations within the silicon electrode. A simple model based on the 1D diffusion equation allows us to qualitatively understand the observed kinetics and demonstrates why high-capacity electrodes are more prone to inhomogeneous lithiation reactions. PMID:27324109

  15. Realization of a scanning ion beam monitor; Realisation d'un dispositif de controle et d'imagerie de faisceaux balayes d'ions

    Energy Technology Data Exchange (ETDEWEB)

    Pautard, C

    2008-07-15

    During this thesis, a scanning ion beam monitor has been developed in order to measure on-line fluence spatial distributions. This monitor is composed of an ionization chamber, Hall Effect sensors and a scintillator. The ionization chamber set between the beam exit and the experiment measures the ion rate. The beam spot is localized thanks to the Hall Effect sensors set near the beam sweeping magnets. The scintillator is used with a photomultiplier tube to calibrate the ionization chamber and with an imaging device to calibrate the Hall Effect sensors. This monitor was developed to control the beam lines of a radiobiology dedicated experimentation room at GANIL. These experiments are held in the context of the research in hadron-therapy. As a matter of fact, this new cancer treatment technique is based on ion irradiations and therefore demands accurate knowledge about the relation between the dose deposit in biological samples and the induced effects. To be effective, these studies require an on-line control of the fluence. The monitor has been tested with different beams at GANIL. Fluence can be measured with a relative precision of {+-}4% for a dose rate ranging between 1 mGy/s and 2 Gy/s. Once permanently set on the beam lines dedicated to radiobiology at GANIL, this monitor will enable users to control the fluence spatial distribution for each irradiation. The scintillator and the imaging device are also used to control the position, the spot shape and the energy of different beams such as those used for hadron-therapy. (author)

  16. An Improved Backstepping-Based Controller for Three-Dimensional Trajectory Tracking of a Midwater Trawl System

    Directory of Open Access Journals (Sweden)

    Zhao Yan

    2016-01-01

    Full Text Available An improved backstepping control method for three-dimensional trajectory tracking of a midwater trawl system is investigated. A new mathematical model of the trawl system while considering the horizontal expansion effect of two otter boards is presented based on the Newton Euler method. Subsequently, an active path tracking strategy of the trawl system based on the backstepping method is proposed. The nonstrict feedback characteristic of the proposed model employs a control allocation method and several parallel nonlinear PID (Proportion Integration Differentiation controllers to eliminate the high-order state variables. Then, the stability analysis by the Lyapunov Stability Theory shows that the proposed controller can maintain the stability of the trawl system even with the presence of external disturbances. To validate the proposed controller, a simulation comparison with a linear PID controller was conducted. The simulation results illustrate that the improved backstepping controller is effective for three-dimensional trajectory tracking of the midwater trawl system.

  17. Design of robust fuzzy controller for ship course-tracking based on RBF network and backstepping approach

    Institute of Scientific and Technical Information of China (English)

    ZHANG Song-tao; REN Guang

    2006-01-01

    This study presents an adaptive fuzzy neural network (FNN) control system for the ship steering autopilot. For the Norrbin ship steering mathematical model with the nonlinear and uncertain dynamic characteristics, an adaptive FNN control system is designed to achieve high-precision track control via the backstepping approach. In the adaptive FNN control system, a FNN backstepping controller is a principal controller which includes a FNN estimator used to estimate the uncertainties, and a robust controller is designed to compensate the shortcoming of the FNN backstepping controller. All adaptive learning algorithms in the adaptive FNN control system are derived from the sense of Lyapunov stability analysis, so that system-tracking stability can be guaranteed in the closed-loop system. The effectiveness of the proposed adaptive FNN control system is verified by simulation results.

  18. Improved 6-Plex Tandem Mass Tags Quantification Throughput Using a Linear Ion Trap-High-Energy Collision Induced Dissociation MS(3) Scan.

    Science.gov (United States)

    Liu, Jane M; Sweredoski, Michael J; Hess, Sonja

    2016-08-01

    The use of tandem mass tags (TMT) as an isobaric labeling strategy is a powerful method for quantitative proteomics, yet its accuracy has traditionally suffered from interference. This interference can be largely overcome by selecting MS(2) fragment precursor ions for high-energy collision induced dissociation (HCD) MS(3) analysis in an Orbitrap scan. While this approach minimizes the interference effect, sensitivity suffers due to the high AGC targets and long acquisition times associated with MS(3) Orbitrap detection. We investigated whether acquiring the MS(3) scan in a linear ion trap with its lower AGC target would increase overall quantification levels with a minimal effect on precision and accuracy. Trypsin-digested proteins from Saccharomyces cerevisiae were tagged with 6-plex TMT reagents. The sample was subjected to replicate analyses using either the Orbitrap or the linear ion trap for the HCD MS(3) scan. HCD MS(3) detection in the linear ion trap vs Orbitrap increased protein identification by 66% with minor loss in precision and accuracy. Thus, the use of a linear ion trap-HCD MS(3) scan during a 6-plex TMT experiment can improve overall identification levels while maintaining the power of multiplexed quantitative analysis. PMID:27377715

  19. Backstepping-based lag synchronization of a complex permanent magnet synchronous motor system

    Institute of Scientific and Technical Information of China (English)

    Wang Xing-Yuan; Zhang Hao

    2013-01-01

    Through introducing the concept of complex current and resetting cross-coupling term,this paper proposes a novel complex permanent magnet synchronous motor system and analyzes its properties.Based on a complex permanent magnet synchronous motor system,we design controllers and achieve lag synchronizations both in real part and imaginary part with backstepping method.In our study,we take complex current,time delay,and structure of complex system into consideration.Numerical simulation results demonstrate the validity of controllers.

  20. Attitude Analysis and Robust Adaptive Backstepping Sliding Mode Control of Spacecrafts Orbiting Irregular Asteroids

    Directory of Open Access Journals (Sweden)

    Chunhui Liang

    2014-01-01

    Full Text Available Attitude stability analysis and robust control algorithms for spacecrafts orbiting irregular asteroids are investigated in the presence of model uncertainties and external disturbances. Rigid spacecraft nonlinear attitude models are considered and detailed attitude stability analysis of spacecraft subjected to the gravity gradient torque in an irregular central gravity field is included in retrograde orbits and direct orbits using linearized system model. The robust adaptive backstepping sliding mode control laws are designed to make the attitude of the spacecrafts stabilized and responded accurately to the expectation in the presence of disturbances and parametric uncertainties. Numerical simulations are included to illustrate the spacecraft performance obtained using the proposed control laws.

  1. Backstepping-based lag synchronization of a complex permanent magnet synchronous motor system

    International Nuclear Information System (INIS)

    Through introducing the concept of complex current and resetting cross-coupling term, this paper proposes a novel complex permanent magnet synchronous motor system and analyzes its properties. Based on a complex permanent magnet synchronous motor system, we design controllers and achieve lag synchronizations both in real part and imaginary part with backstepping method. In our study, we take complex current, time delay, and structure of complex system into consideration. Numerical simulation results demonstrate the validity of controllers. (interdisciplinary physics and related areas of science and technology)

  2. Full adaptive backstepping design of a Speed Sensorless Field Oriented Controller for an Induction Motor

    DEFF Research Database (Denmark)

    Rasmussen, Henrik; Vadstrup, P.; Børsting, H.

    2001-01-01

    princip. A full proof for convergence of states is presented together with a stability proof for the parameter estimates. When the system is persistently excited simulations and experiments show convergence of the parameters. The observer is used in a Rotor Field Oriented Control strategy and verified by......It is well known that modern induction motor control rely on a good dynamic model of the motor. Full state variable information together with exact parameter knowledge is needed. The aim of this work is to fulfill these needs by use of a novel nonlinear observer structure based on the backstepping...

  3. Robust Adaptive Backstepping Control Design for a Nonlinear Hydraulic-Mechanical System

    DEFF Research Database (Denmark)

    Choux, Martin; Karimi, Hamid Reza; Hovland, Geir;

    2009-01-01

    The complex dynamics that characterize hydraulic systems make it difficult for the control design to achieve prescribed goals in an efficient manner. In this paper, we present the design and analysis of a robust nonlinear controller for a nonlinear hydraulic-mechanical (NHM) system. The system...... consists of an electrohydraulic servo valve and two hydraulic cylinders. Specifically, by considering a part of the dynamics of the NHM system as a norm-bounded uncertainty, two adaptive controllers are developed based on the backstepping technique that ensure the tracking error signals asymptotically...... the Lyapunov functional method and inequality techniques. Simulation results demonstrate the performance and feasibility of the proposed method....

  4. Production of monodisperse uranium oxide particles and their characterization by scanning electron microscopy and secondary ion mass spectrometry

    Science.gov (United States)

    Erdmann, N.; Betti, M.; Stetzer, O.; Tamborini, G.; Kratz, J. V.; Trautmann, N.; van Geel, J.

    2000-10-01

    Secondary ion mass spectrometry (SIMS) can be confidently used to measure uranium isotopic ratios in single particles. Dense particles of known isotopic composition and size allow the precision and the accuracy of the applied procedure to be estimated. These particles can be obtained by dissolving standard reference uranium materials, nebulizing the solution in droplets of proper diameter and collecting the particles after the desolvation and calcination of the droplets. A new instrumental set up, based on a commercial vibrating orifice aerosol generator to generate monodisperse droplets of the solutions from four uranium oxide reference materials, is described. The droplets were dried and calcined in a sequence of three furnaces. The morphology of the monodisperse uranium oxide particles was studied by scanning electron microscopy. It was observed that the particles were nearly spherical and consisted of dense material. Their diameter distribution evidenced the presence of two populations mainly, the first showing a narrow distribution with a maximum centered at approximately 1 μm. The first statistical moment ratios between the two populations remained practically constant at 1.24±0.01. This demonstrated that the second population was due to the formation of one particle from two droplets of solution (theoretical double mass≡diameter ratio of 2=1.26). Secondary ion mass spectrometry was used to verify the isotopic composition of the produced particles. Typical accuracies of better than 0.4% for 235U/ 238U and a few percent for the minor isotopes have been achieved. For the determination of the 236U content, the signal at mass M=239 (due to 238UH +) was used to correct the 235UH + contribution to 236U at mass M=236, greatly improving the accuracy of the 236/238 ratio with increasing enrichment of the 235U isotope.

  5. Analysis of shape and spatial interaction of synaptic vesicles using data from focused ion beam scanning electron microscopy (FIB-SEM)

    DEFF Research Database (Denmark)

    Khanmohammadi, Mahdieh; Waagepetersen, Rasmus Plenge; Sporring, Jon

    2015-01-01

    deviations from spherical shape and systematic trends in their orientation. We studied three-dimensional representations of synapses obtained by manual annotation of focused ion beam scanning electron microscopy (FIB-SEM) images of male mouse brain. The configurations of synaptic vesicles were regarded...

  6. Adaptive Recurrent Network Network Uncertainty Observer Based Integral Backstepping Control for a PMSM Drive System

    Directory of Open Access Journals (Sweden)

    Chih-Hong Lin

    2012-03-01

    Full Text Available The permanent magnet synchronous motor (PMSM is suitable for high-performance servo applications and has been used widely for the industrial robots, computer-numerically-controlled (CNC machine tools and elevators. The control performance of the actual PMSM drive system depends on many parameters, such as parameter variations, external load disturbance, and friction force. Their relationships are complex and the actual PMSM drive system has the properties of nonlinear uncertainty and time-varying characteristics. It is difficult to establish an accurate model for the nonlinear uncertainty and time-varying characteristics of the actual PMSM drive system Therefore, an adaptive recurrent neural network uncertainty observer (ARNNUO based integral backstepping control system is developed to overcome this problem in this paper. The proposed control strategy is based on integral backstepping control combined with RNN uncertainty observer to estimate the required lumped uncertainty. An adaptive rule of the RNN uncertainty observer is employed to on-line adjust the weights of sigmoidal functions by using the gradient descent method and the backpropagation algorithm in according to Lyapunov function. This ARNNUO has the on-line learning ability to respond to the system’s nonlinear and time-varying behaviors. Experimental results are executed to show the control performance of the proposed control scheme.

  7. Comparative morphology analysis of live blood platelets using scanning ion conductance and robotic dark-field microscopy.

    Science.gov (United States)

    Kraus, Max-Joseph; Seifert, Jan; Strasser, Erwin F; Gawaz, Meinrad; Schäffer, Tilman E; Rheinlaender, Johannes

    2016-09-01

    Many conventional microscopy techniques for investigating platelet morphology such as electron or fluorescence microscopy require highly invasive treatment of the platelets such as fixation, drying and metal coating or staining. Here, we present two unique but entirely different microscopy techniques for direct morphology analysis of live, unstained platelets: scanning ion conductance microscopy (SICM) and robotic dark-field microscopy (RDM). We demonstrate that both techniques allow for a quantitative evaluation of the morphological features of live adherent platelets. We show that their morphology can be quantified by both techniques using the same geometric parameters and therefore can be directly compared. By imaging the same identical platelets subsequently with SICM and RDM, we found that area, perimeter and circularity of the platelets are directly correlated between SICM and dark-field microscopy (DM), while the fractal dimension (FD) differed between the two microscopy techniques. We show that SICM and RDM are both valuable tools for the ex vivo investigation of the morphology of live platelets, which might contribute to new insights into the physiological and pathophysiological role of platelet spreading. PMID:27063564

  8. 3D Plant Cell Architecture of Arabidopsis thaliana (Brassicaceae Using Focused Ion Beam–Scanning Electron Microscopy

    Directory of Open Access Journals (Sweden)

    Bhawana

    2014-06-01

    Full Text Available Premise of the study: Focused ion beam–scanning electron microscopy (FIB-SEM combines the ability to sequentially mill the sample surface and obtain SEM images that can be used to create 3D renderings with micron-level resolution. We have applied FIB-SEM to study Arabidopsis cell architecture. The goal was to determine the efficacy of this technique in plant tissue and cellular studies and to demonstrate its usefulness in studying cell and organelle architecture and distribution. Methods: Seed aleurone, leaf mesophyll, stem cortex, root cortex, and petal lamina from Arabidopsis were fixed and embedded for electron microscopy using protocols developed for animal tissues and modified for use with plant cells. Each sample was sectioned using the FIB and imaged with SEM. These serial images were assembled to produce 3D renderings of each cell type. Results: Organelles such as nuclei and chloroplasts were easily identifiable, and other structures such as endoplasmic reticula, lipid bodies, and starch grains were distinguishable in each tissue. Discussion: The application of FIB-SEM produced 3D renderings of five plant cell types and offered unique views of their shapes and internal content. These results demonstrate the usefulness of FIB-SEM for organelle distribution and cell architecture studies.

  9. Study on the dose response characteristics of a scanning liquid ion-chamber electronic portal imaging device

    CERN Document Server

    Ma Shao Gang; Song Yi Xin

    2002-01-01

    Objective: To study the dose response characteristics and the influence factors such as gantry angle, field size and acquisition mode on the dosimetric response curves, when using a scanning liquid ion-chamber electronic portal imaging device (EPID) for dose verification. Methods: All experiments were carried out on a Varian 600 C/D accelerator (6 MV X-ray) equipped with a Varian PortalVision sup T sup M MK2 type EPID. To obtain the dose response curve, the relationship between the incident radiation intensity to the detector and the pixel value output from the EPID were established. Firstly, the different dose rates of 6 MV X-rays were obtained by varying SSD. Secondly, three digital portal images were acquired for each dose rate using the EPID and averaged to avoid the influence of the dose rate fluctuations of the accelerator. The pixel values of all images were read using self-designed image analysis software, and and average for a region consisting of 11 x 11 pixels around the center was taken as the res...

  10. Characterization of stainless steel through Scanning Electron Microscopy, nitrided in the process of implantation of immersed ions in plasma

    International Nuclear Information System (INIS)

    The present project carries out the investigation of the nitridation of the austenitic stainless steel schedule 304, applying the novel technology of installation of nitrogen ions in immersed materials in plasma (Plll), by means of which they modify those properties of the surface of the steel. The obtained results by means of tests of Vickers microhardness, shows that the hardness was increment from 266 to 740 HV (microhardness units). It was determined by means of scanning electron microscopy, the one semiquantitative chemical analysis of the elements that constitute the austenitic stainless steel schedule 304; the obtained results, show to the nitrogen like an element of their composition in the pieces where carried out to end the PIII technology. The parameters of the plasma with which carried out the technology Plll, were monitored and determined by means of electric probes, and with which it was determined that the density of particles is stable in the interval of 1x10-1 at 3x10-1Torr, and it is where better results of hardness were obtained. That reported in this work, they are the first results obtained when applying the technology Plll in Mexico, and with base in these, it is even necessary to investigate and to deepen until to dominate the process and to be in possibilities of proposing it to be carried out and exploited in an industrial way. (Author)

  11. Neutral Particle Analyzer Vertically Scanning Measurements of MHD-induced Energetic Ion Redistribution or Loss in the National Spherical Torus Experiment

    Energy Technology Data Exchange (ETDEWEB)

    S.S. Medley, R. Andre, R.E. Bell, D.S. Darrow, C.W. Domier, E.D. Fredrickson, N.N. Gorelenkov, S.M. Kaye, B.P. LeBlanc, K.C. Lee, F.M. Levinton, D. Liu, N.C. Luhmann, Jr., J.E. Menard, H. Park, D. Stutman, A.L. Roquemore, K. Tritz, H. Yuh and the NSTX Team

    2007-11-15

    Observations of magneto-hydro-dynamic (MHD) induced redistribution or loss of energetic ions measured using the vertically scanning capability of the Neutral Particle Analyzer diagnostic on the National Spherical Torus Experiment (NSTX) are presented along with TRANSP and ORBIT code analysis of the results. Although redistribution or loss of energetic ions due to bursting fishbone-like and low-frequency (f ~ 10 kHz) kinktype MHD activity has been reported previously, the primary goal of this work is to study redistribution or loss due to continuous Alfvénic (f ~ 20 – 150 kHz) modes, a topic that heretofore has not been investigated in detail for NSTX plasmas. Initial indications are that the former drive energetic ion loss whereas the continuous Alfvénic modes only cause redistribution and the energetic ions remain confined.

  12. Scanning electrochemical microscopy study of ion annihilation electrogenerated chemiluminescence of rubrene and [Ru(bpy)3]2+.

    Science.gov (United States)

    Rodríguez-López, Joaquín; Shen, Mei; Nepomnyashchii, Alexander B; Bard, Allen J

    2012-06-01

    Scanning electrochemical microscopy (SECM) was used for the study of electrogenerated chemiluminescence (ECL) in the radical annihilation mode. The concurrent steady-state generation of radical ions in the microgap formed between a SECM probe and a transparent microsubstrate provides a distance-dependent ECL signal that can provide information about the kinetics, stability, and mechanism of the light emission process. In the present study, the ECL emission from rubrene and [Ru(bpy)(3)](2+) was used to model the system by carrying out experiments with the SECM and light-detecting apparatus inside an inert atmosphere box. We studied the influence of the distance between the two electrodes, d, and the annihilation kinetics on the ECL light emission profiles under steady-state conditions, as well as the ECL profiles when carrying out cyclic voltammetry (CV) at a fixed d. Experimental results are compared to simulated results obtained through commercial finite element method software. The light produced by annihilation of the ions was a function of d; stronger light was observed at smaller d. The distance dependence of the ECL emission allows the construction of light approach curves in a similar fashion as with the tip currents in the feedback mode of SECM. These ECL approach curves provide an additional channel to describe the reaction kinetics that lead to ECL; good agreement was found between the ECL approach curve emission profile and the simulated results for a fast, diffusion-limited second-order annihilation process (k(ann) > 10(7) M(-1) s(-1)). In the CV mode at fixed distance, the ECL emission of rubrene showed two distinct signals at different potentials when fixing the substrate to generate the radical cation and scanning the tip to generate the radical anion. The first signal (pre-emission) corresponded to an emission well before reaching the generation of the radical anion and was more intense on Au than on Pt. The second ECL signal showed the expected

  13. Attitude Stabilization Control of a Quadrotor UAV by Using Backstepping Approach

    Directory of Open Access Journals (Sweden)

    Xing Huo

    2014-01-01

    Full Text Available The modeling and attitude stabilization control problems of a four-rotor vertical takeoff and landing unmanned air vehicle (UAV known as the quadrotor are investigated. The quadrotor’s attitude is represented by the unit quaternion rather than Euler angles to avoid singularity problem. Taking dynamical behavior of motors into consideration and ignoring aerodynamic effect, a nonlinear controller is developed to stabilize the attitude. The control design is accomplished by using backstepping control technique. The proposed control law is based on the compensation for the Coriolis and gyroscope torques. Applying Lyapunov stability analysis proves that the closed-loop attitude system is asymptotic stable. Moreover, the controller can guarantee that all the states of the system are uniformly ultimately bounded in the presence of external disturbance torque. The effectiveness of the proposed control approach is analytically authenticated and also validated via simulation study.

  14. Fuzzy Backstepping Torque Control Of Passive Torque Simulator With Algebraic Parameters Adaptation

    Science.gov (United States)

    Ullah, Nasim; Wang, Shaoping; Wang, Xingjian

    2015-07-01

    This work presents fuzzy backstepping control techniques applied to the load simulator for good tracking performance in presence of extra torque, and nonlinear friction effects. Assuming that the parameters of the system are uncertain and bounded, Algebraic parameters adaptation algorithm is used to adopt the unknown parameters. The effect of transient fuzzy estimation error on parameters adaptation algorithm is analyzed and the fuzzy estimation error is further compensated using saturation function based adaptive control law working in parallel with the actual system to improve the transient performance of closed loop system. The saturation function based adaptive control term is large in the transient time and settles to an optimal lower value in the steady state for which the closed loop system remains stable. The simulation results verify the validity of the proposed control method applied to the complex aerodynamics passive load simulator.

  15. Backstepping design of missile guidance and control based on adaptive fuzzy sliding mode control

    Directory of Open Access Journals (Sweden)

    Ran Maopeng

    2014-06-01

    Full Text Available This paper presents an integrated missile guidance and control law based on adaptive fuzzy sliding mode control. The integrated model is formulated as a block-strict-feedback nonlinear system, in which modeling errors, unmodeled nonlinearities, target maneuvers, etc. are viewed as unknown uncertainties. The adaptive nonlinear control law is designed based on backstepping and sliding mode control techniques. An adaptive fuzzy system is adopted to approximate the coupling nonlinear functions of the system, and for the uncertainties, we utilize an online-adaptive control law to estimate the unknown parameters. The stability analysis of the closed-loop system is also conducted. Simulation results show that, with the application of the adaptive fuzzy sliding mode control, small miss distances and smooth missile trajectories are achieved, and the system is robust against system uncertainties and external disturbances.

  16. Backstepping design of missile guidance and control based on adaptive fuzzy sliding mode control

    Institute of Scientific and Technical Information of China (English)

    Ran Maopeng; Wang Qing; Hou Delong; Dong Chaoyang

    2014-01-01

    This paper presents an integrated missile guidance and control law based on adaptive fuzzy sliding mode control. The integrated model is formulated as a block-strict-feedback nonlinear system, in which modeling errors, unmodeled nonlinearities, target maneuvers, etc. are viewed as unknown uncertainties. The adaptive nonlinear control law is designed based on backstepping and sliding mode control techniques. An adaptive fuzzy system is adopted to approximate the coupling nonlinear functions of the system, and for the uncertainties, we utilize an online-adaptive control law to estimate the unknown parameters. The stability analysis of the closed-loop system is also conducted. Simulation results show that, with the application of the adaptive fuzzy sliding mode control, small miss distances and smooth missile trajectories are achieved, and the system is robust against system uncertainties and external disturbances.

  17. Trajectory tracking control of underactuated USV based on modified backstepping approach

    Directory of Open Access Journals (Sweden)

    Dong Zaopeng

    2015-09-01

    Full Text Available This paper presents a state feedback based backstepping control algorithm to address the trajectory tracking problem of an underactuated Unmanned Surface Vessel (USV in the horizontal plane. A nonlinear three Degree of Freedom (DOF underactuated dynamic model for USV is considered, and trajectory tracking controller that can track both curve trajectory and straight line trajectory with high accuracy is designed as the well known Persistent Exciting (PE conditions of yaw velocity is completely relaxed in our study. The proposed controller has further been enriched by incorporating an integral action additionally for enhancing the steady state performance and control precision of the USV trajectory tracking control system. Global stability of the overall system is proved by Lyapunov theory and Barbalat’s Lemma, and then simulation experiments are carried out to demonstrate the effectiveness of the controller designed.

  18. Adaptive Backstepping Control Based on Floating Offshore High Temperature Superconductor Generator for Wind Turbines

    Directory of Open Access Journals (Sweden)

    Feng Yang

    2014-01-01

    Full Text Available With the rapid development of offshore wind power, the doubly fed induction generator and permanent magnet synchronous generator cannot meet the increasing request of power capacity. Therefore, superconducting generator should be used instead of the traditional motor, which can improve generator efficiency, reduce the weight of wind turbines, and increase system reliability. This paper mainly focuses on nonlinear control in the offshore wind power system which is consisted of a wind turbine and a high temperature superconductor generator. The proposed control approach is based on the adaptive backstepping method. Its main purpose is to regulate the rotor speed and generator voltage, therefore, achieving the maximum power point tracking (MPPT, improving the efficiency of a wind turbine, and then enhancing the system’s stability and robustness under large disturbances. The control approach can ensure high precision of generator speed tracking, which is confirmed in both the theoretical analysis and numerical simulation.

  19. Design of an adaptive backstepping controller for auto-berthing a cruise ship under wind loads

    Science.gov (United States)

    Park, Jong-Yong; Kim, Nakwan

    2014-06-01

    The auto-berthing of a ship requires excellent control for safe accomplishment. Crabbing, which is the pure sway motion of a ship without surge velocity, can be used for this purpose. Crabbing is induced by a peculiar operation procedure known as the push-pull mode. When a ship is in the push-pull mode, an interacting force is induced by complex turbulent flow around the ship generated by the propellers and side thrusters. In this paper, three degrees of freedom equations of the motions of crabbing are derived. The equations are used to apply the adaptive backstepping control method to the auto-berthing controller of a cruise ship. The controller is capable of handling the system nonlinearity and uncertainty of the berthing process. A control allocation algorithm for a ship equipped with two propellers and two side thrusters is also developed, the performance of which is validated by simulation of auto-berthing.

  20. Modeling and Backstepping-based Nonlinear Control Strategy for a 6 DOF Quadrotor Helicopter

    Institute of Scientific and Technical Information of China (English)

    Ashfaq Ahmad Mian; Wang Daobo

    2008-01-01

    In this article,a nonlinear model of an underactuated six degrees of freedom (6 DOF) quadrotor helicopter is derived on the basis of the Newton-Euler formalism.The derivation comprises determining equations of the motion of the quadrotor in three dimensions andapproximating the actuation forces through the modeling of aerodynamic coefficients and electric motor dynamics.The derived modelcomposed of translatioual and rotational subsystems is dynamically unstable,so a sequential nonlinear control strategy is used.The con-trol strategy includes feedback linearization coupled with a PD controller for the translational subsystem and a backstepping-based PID nonlinear controller for the rotational subsystem of the quadrotor.The performances of the nonlinear control method are evaluated by nonlinear simulation and the results demonstrate the effectiveness of the proposed control strategy for the quadrotor helicopter inquasi-stationary flights.

  1. Adaptive Backstepping Controller Design for Leveling Control of an Underwater Platform Based on Joint Space

    Directory of Open Access Journals (Sweden)

    Zhi-Lin Zeng

    2014-01-01

    Full Text Available This paper focuses on high precision leveling control of an underwater heavy load platform, which is viewed as an underwater parallel robot on the basis of its work pattern. The kinematic of platform with deformation is analyzed and the dynamics model of joint space is established. An adaptive backstepping controller according to Lyapunov's function is proposed for leveling control of platform based on joint space. Furthermore, the “lowest point fixed angle error” leveling scheme called “chase” is chosen for leveling control of platform. The digital simulation and practical experiment of single joint space actuator are carried out, and the results show high precision servo control of joint space. On the basis of this, the platform leveling control simulation relies on the hardware-in-loop system. The results indicate that the proposed controller can effectively restrain the influence from system parameter uncertainties and external disturbance to realize high precision leveling control of the underwater platform.

  2. A Back-stepping Based Trajectory Tracking Controller for a Non-chained Nonholonomic Spherical Robot

    Institute of Scientific and Technical Information of China (English)

    Zhan Qiang; Liu Zengbo; Cai Yao

    2008-01-01

    Spherical robot has good static and dynamic stability, which provides it with strong viability in hostile environment, but the lack of effective control methods has hindered its application and development. This article deals with the dynamic trajectory tracking problem of the spherical robot BHQ-2 designed for unmanned environment exploration. The dynamic model of the spherical robot is established with a simplified Boltzmann-Hamel equation, based on which a trajectory tracking controller is designed by using the back-stepping method. The convergence of the controller is proved with the Lyapunov stability theory. Numerical simulations show that with the controller the robot can globally and asymptotically track desired trajectories, both linear and circular.

  3. Design Novel Soft Computing Backstepping Controller with Application to Nonlinear Dynamic Uncertain System

    Directory of Open Access Journals (Sweden)

    Amin Jalali

    2013-09-01

    Full Text Available The increasing demand for multi-degree-of-freedom (DOF continuum robot in presence of highly nonlinear dynamic parameters in a number of industries has motivated a flurry of research in the development of soft computing nonlinear methodology. This robot is capable of providing smooth and isotropic three-dimensional motion in each joint. Compared to conventional robotic manipulators that offer the same motion capabilities, the innovative spherical motor possesses several advantages. Not only can the spherical motor combine 3-DOF motion in a single joint, it has a large range of motion with no singularities in its workspace. This research contributes to the on-going research effort by exploring alternate methods for controlling the continuum robot manipulator. This research addresses two basic issues related to the control of a continuum robots; (1 a more accurate representation of the dynamic model of an existing prototype, and (2 the design of a robust feedback controller. The robust backstepping controller proposed in this research is used to further demonstrate the appealing features exhibited by the continuum robot. Robust feedback controller is used to position control of continuum robot in presence of uncertainties. Using Lyapunov type stability arguments, a robust backstepping controller is designed to achieve this objective. The controller developed in this research is designed in two steps. Firstly, a robust stabilizing torque is designed for the nominal continuum robot dynamics derived using the constrained Lagrangian formulation. Next, the fuzzy logic methodology applied to it to solution uncertainty problem. The fuzzy model free problem is formulated to minimize the nonlinear formulation of continuum robot. The eventual stability of the controller depends on the torque generating capabilities of the continuum robots.

  4. SU-E-T-562: Scanned Percent Depth Dose Curve Discrepancy for Photon Beams with Physical Wedge in Place (Varian IX) Using Different Sensitive Volume Ion Chambers

    International Nuclear Information System (INIS)

    Purpose: To investigate and report the discrepancy of scanned percent depth dose (PDD) for photon beams with physical wedge in place when using ion chambers with different sensitive volumes. Methods/Materials: PDD curves of open fields and physical wedged fields (15, 30, 45, and 60 degree wedge) were scanned for photon beams (6MV and 10MV, Varian iX) with field size of 5x5 and 10x10 cm using three common scanning chambers with different sensitive volumes - PTW30013 (0.6cm3), PTW23323 (0.1cm3) and Exradin A16 (0.007cm3). The scanning system software used was OmniPro version 6.2, and the scanning water tank was the Scanditronix Wellhoffer RFA 300.The PDD curves from the three chambers were compared. Results: Scanned PDD curves of the same energy beams for open fields were almost identical between three chambers, but the wedged fields showed non-trivial differences. The largest differences were observed between chamber PTW30013 and Exradin A16. The differences increased as physical wedge angle increased. The differences also increased with depth, and were more pronounced for 6MV beam. Similar patterns were shown for both 5x5 and 10x10 cm field sizes. For open fields, all PDD values agreed with each other within 1% at 10cm depth and within 1.62% at 20 cm depth. For wedged fields, the difference of PDD values between PTW30013 and A16 reached 4.09% at 10cm depth, and 5.97% at 20 cm depth for 6MV with 60 degree physical wedge. Conclusion: We observed a significant difference in scanned PDD curves of photon beams with physical wedge in place obtained when using different sensitive volume ion chambers. The PDD curves scanned with the smallest sensitive volume ion chamber showed significant difference from larger chamber results, beyond 10cm depth. We believe this to be caused by varying response to beam hardening by the wedges

  5. 3D imaging of cells and tissues by focused ion beam/scanning electron microscopy (FIB/SEM).

    Science.gov (United States)

    Drobne, Damjana

    2013-01-01

    Integration of a scanning electron microscope (SEM) and focused ion beam (FIB) technology into a single FIB/SEM system permits use of the FIB as a nano-scalpel to reveal site-specific subsurface microstructures which can be examined in great detail by SEM. The FIB/SEM technology is widely used in the semiconductor industry and material sciences, and recently its use in the life sciences has been initiated. Samples for FIB/SEM investigation can be either embedded in a plastic matrix, the traditional means of preparation of transmission electron microscopy (TEM) specimens, or simply dried as in samples prepared for SEM imaging. Currently, FIB/SEM is used in the life sciences for (a) preparation by the lift-out technique of lamella for TEM analysis, (b) tomography of samples embedded in a matrix, and (c) in situ site-specific FIB milling and SEM imaging using a wide range of magnifications. Site-specific milling and imaging has attracted wide interest as a technique in structural research of single eukaryotic and prokaryotic cells, small animals, and different animal tissue, but it still remains to be explored more thoroughly. In the past, preparation of samples for site-specific milling and imaging by FIB/SEM has typically adopted the embedding techniques used for TEM samples, and which have been very well described in the literature. Sample preparation protocols for the use of dried samples in FIB/SEM have been less well investigated. The aim of this chapter is to encourage application of FIB/SEM on dried biological samples. A detailed description of conventional dried sample preparation and FIB/SEM investigation of dried biological samples is presented. The important steps are described and illustrated, and direct comparison between embedded and dried samples of same tissues is provided. The ability to discover links between gross morphology of the tissue or organ, surface characteristics of any selected region, and intracellular structural details on the nanometer

  6. Rapid phase-correlated rescanning irradiation improves treatment time in carbon-ion scanning beam treatment under irregular breathing

    Science.gov (United States)

    Mori, Shinichiro; Furukawa, Takuji

    2016-05-01

    To shorten treatment time in pencil beam scanning irradiation, we developed rapid phase-controlled rescanning (rPCR), which irradiates two or more isoenergy layers in a single gating window. Here, we evaluated carbon-ion beam dose distribution with rapid and conventional PCR (cPCR). 4 dimensional computed tomography (4DCT) imaging was performed on 12 subjects with lung or liver tumors. To compensate for intrafractional range variation, the field-specific target volume (FTV) was calculated using 4DCT within the gating window (T20–T80). We applied an amplitude-based gating strategy, in which the beam is on when the tumor is within the gating window defined by treatment planning. Dose distributions were calculated for layered phase-controlled rescanning under an irregular respiratory pattern, although a single 4DCT data set was used. The number of rescannings was eight times. The prescribed doses were 48 Gy(RBE)/1 fr (where RBE is relative biological effectiveness) delivered via four beam ports to the FTV for the lung cases and 45 Gy(RBE)/2 fr delivered via two beam ports to the FTV for the liver cases. In the liver cases, the accumulated dose distributions showed an increased magnitude of hot/cold spots with rPCR compared with cPCR. The results of the dose assessment metrics for the cPCR and rPCR were very similar. The D 95, D max, and D min values (cPCR/rPCR) averaged over all the patients were 96.3  ±  0.9%/96.0  ±  1.2%, 107.3  ±  3.6%/107.1  ±  2.9%, and 88.8  ±  3.2%/88.1  ±  3.1%, respectively. The treatment times in cPCR and rPCR were 110.7 s and 53.5 s, respectively. rPCR preserved dose conformation under irregular respiratory motion and reduced the total treatment time compared with cPCR.

  7. Geant4 simulation for a study of a possible use of carbon ion pencil beams for the treatment of ocular melanomas with the active scanning system at CNAO

    Science.gov (United States)

    Farina, E.; Piersimoni, P.; Riccardi, C.; Rimoldi, A.; Tamborini, A.; Ciocca, M.

    2015-12-01

    The aim of this work was to study a possible use of carbon ion pencil beams (delivered with active scanning modality) for the treatment of ocular melanomas at the Centro Nazionale di Adroterapia Oncologica (CNAO). The promising aspect of carbon ions radiotherapy for the treatment of this disease lies in its superior relative radio-biological effectiveness (RBE). The Monte Carlo (MC) Geant4 10.00 toolkit was used to simulate the complete CNAO extraction beamline, with the active and passive components along it. A human eye modeled detector, including a realistic target tumor volume, was used as target. Cross check with previous studies at CNAO using protons allowed comparisons on possible benefits on using such a technique with respect to proton beams. Experimental data on proton and carbon ion beams transverse distributions were used to validate the simulation.

  8. Development of a low-cost small-sized scanning transmission ion microscope of moderate resolution with educational and other potential applications

    Science.gov (United States)

    Pallone, Arthur

    2009-03-01

    Scanning transmission ion microscopy (STIM) has applications in many fields of study such as materials and device engineering, biological and geological sciences, and the arts. Since STIM is practiced at ion beam facilities, many persons outside of the ion beam community who could benefit from STIM are unaware of its potential. In an effort to better educate the public about STIM, an inexpensive portable demonstration unit suitable for interactive classroom use and public outreach events is under development. The required parts are readily available, mostly at local electronics and office supply stores. Progress toward completion of the demonstration unit and future efforts to modify the unit to support thin film research will be discussed. Activities that demonstrate the three modes of STIM will also be presented.

  9. Extended State Observer Based Adaptive Back-Stepping Sliding Mode Control of Electronic Throttle in Transportation Cyber-Physical Systems

    Directory of Open Access Journals (Sweden)

    Yongfu Li

    2015-01-01

    Full Text Available Considering the high accuracy requirement of information exchange via vehicle-to-vehicle (V2V communications, an extended state observer (ESO is designed to estimate the opening angle change of an electronic throttle (ET, wherein the emphasis is placed on the nonlinear uncertainties of stick-slip friction and spring in the system as well as the existence of external disturbance. In addition, a back-stepping sliding mode controller incorporating an adaptive control law is presented, and the stability and robustness of the system are analyzed using Lyapunov technique. Finally, numerical experiments are conducted using simulation. The results show that, compared with back-stepping control (BSC, the proposed controller achieves superior performance in terms of the steady-state error and rising time.

  10. Scanned ion beam therapy for prostate carcinoma. Comparison of single plan treatment and daily plan-adapted treatment

    Energy Technology Data Exchange (ETDEWEB)

    Hild, Sebastian [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Department of Biophysics, Darmstadt (Germany); University Clinic Erlangen and Friedrich- Alexander-University Erlangen-Nuernberg (FAU), Department of Radiation Oncology, Erlangen (Germany); Graeff, Christian [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Department of Biophysics, Darmstadt (Germany); Rucinski, Antoni [University Clinic Heidelberg, Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg (Germany); Sapienza Universit' a di Roma, Dipartimento di Scienze di Base e Applicate per Ingegneria, Roma (Italy); INFN, Roma (Italy); Zink, Klemens [University of Applied Sciences, Institute for Medical Physics and Radiation Protection, Giessen (Germany); University Medical Center Giessen-Marburg, Department of Radiotherapy and Radiooncology, Marburg (Germany); Habl, Gregor [University Clinic Heidelberg, Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg (Germany); Klinikum rechts der Isar, Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Munich (Germany); Durante, Marco [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Department of Biophysics, Darmstadt (Germany); Technische Universitaet Darmstadt, Faculty of Physics, Darmstadt (Germany); Herfarth, Klaus [University Clinic Heidelberg, Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg (Germany); Bert, Christoph [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Department of Biophysics, Darmstadt (Germany); University Clinic Erlangen and Friedrich- Alexander-University Erlangen-Nuernberg (FAU), Department of Radiation Oncology, Erlangen (Germany); University Hospital Erlangen, Radiation Oncology, Erlangen (Germany)

    2016-02-15

    Intensity-modulated particle therapy (IMPT) for tumors showing interfraction motion is a topic of current research. The purpose of this work is to compare three treatment strategies for IMPT to determine potential advantages and disadvantages of ion prostate cancer therapy. Simulations for three treatment strategies, conventional one-plan radiotherapy (ConvRT), image-guided radiotherapy (IGRT), and online adaptive radiotherapy (ART) were performed employing a dataset of 10 prostate cancer patients with six CT scans taken at one week intervals. The simulation results, using a geometric margin concept (7-2 mm) as well as patient-specific internal target volume definitions for IMPT were analyzed by target coverage and exposure of critical structures on single fraction dose distributions. All strategies led to clinically acceptable target coverage in patients exhibiting small prostate motion (mean displacement < 4 mm), but IGRT and especially ART led to significant sparing of the rectum. In 20 % of the patients, prostate motion exceeded 4 mm causing insufficient target coverage for ConvRT (V95{sub mean} = 0.86, range 0.63-0.99) and IGRT (V95{sub mean} = 0.91, range 0.68-1.00), while ART maintained acceptable target coverage. IMPT of prostate cancer demands consideration of rectal sparing and adaptive treatment replanning for patients exhibiting large prostate motion. (orig.) [German] Adaptive Therapieansaetze fuer sich interfraktionell bewegende Zielvolumina in der intensitaetsmodulierten Partikeltherapie (IMPT) befinden sich zurzeit in der Entwicklung. In dieser Arbeit werden drei Behandlungsstrategien auf moegliche Vor- und Nachteile in der IMPT des Prostatakarzinoms hin untersucht. Auf Basis eines anonymisierten Datensatzes aus 10 Patienten mit Prostatakarzinom wurden die drei Bestrahlungsstrategien, konventionelle Ein-Plan-Strahlentherapie (ConvRT), bildunterstuetzte Strahlentherapie (IGRT) und tagesaktuelle Strahlentherapie (adaptive radiotherapy,ART), simuliert

  11. In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines

    International Nuclear Information System (INIS)

    Pancreatic cancer is the fourth leading cause of cancer deaths, being responsible for 6% of all cancer-related deaths. Conventional radiotherapy with or without additional chemotherapy has been applied in the past in the context of neoadjuvant or adjuvant therapy concepts with only modest results, however new radiation modalities, such as particle therapy with promising physical and biological characteristics, present an alternative treatment option for patients with pancreatic cancer. Up until now the raster scanning technique employed at our institution for the application of carbon ions has been unique, and no radiobiological data using pancreatic cancer cells has been available yet. The aim of this study was to evaluate cytotoxic effects that can be achieved by treating pancreatic cancer cell lines with combinations of X-rays and gemcitabine, or alternatively with carbon ion irradiation and gemcitabine, respectively. Human pancreatic cancer cell lines AsPC-1, BxPC-3 and Panc-1 were irradiated with photons and carbon ions at various doses and treated with gemcitabine. Photon irradiation was applied with a biological cabin X-ray irradiator, and carbon ion irradiation was applied with an extended Bragg peak (linear energy transfer (LET) 103 keV/μm) using the raster scanning technique at the Heidelberg Ion Therapy Center (HIT). Responsiveness of pancreatic cancer cells to the treatment was measured by clonogenic survival. Clonogenic survival curves were then compared to predicted curves that were calculated employing the local effect model (LEM). Cell survival curves were calculated from the surviving fractions of each combination experiment and compared to a drug control that was only irradiated with X-rays or carbon ions, without application of gemcitabine. In terms of cytotoxicity, additive effects were achieved for the cell lines Panc-1 and BxPC-3, and a slight radiosensitizing effect was observed for AsPC-1. Relative biological effectiveness (RBE) of carbon

  12. Backstepping Based Global Exponential Stabilization of a Tracked Mobile Robot with Slipping Perturbation

    Institute of Scientific and Technical Information of China (English)

    Bo Zhou; Jianda Han; Xianzhong Dai

    2011-01-01

    While the nonholonomic robots with no-slipping constraints are studied extensively nowadays, the slipping effect is inevitable in many practical applications and should be considered necessarily to achieve autonomous navigation and control purposes especially in outdoor environments. In this paper the robust point stabilization problem of a tracked mobile robot is discussed in the presence of track slipping, which can be treated as model perturbation that violates the pure nonholonomic constraints. The kinematic model of the tracked vehicle is created, in which the slipping is assumed to be a time-varying parameter under certain assumptions of track-soil interaction. By transforming the original system to the special chained form of nonholonomic system, the integrator backstepping procedure with a state-scaling technique is used to construct the controller to stabilize the system at the kinematic level. The global exponential stability of the final system can be guaranteed by Lyapunov theory. Simulation results with different initial states and slipping parameters demonstrate the fast convergence, robustness and insensitivity to the initial state of the proposed method.

  13. Advancing Control for Shield Tunneling Machine by Backstepping Design with LuGre Friction Model

    Directory of Open Access Journals (Sweden)

    Haibo Xie

    2014-01-01

    Full Text Available Shield tunneling machine is widely applied for underground tunnel construction. The shield machine is a complex machine with large momentum and ultralow advancing speed. The working condition underground is rather complicated and unpredictable, and brings big trouble in controlling the advancing speed. This paper focused on the advancing motion control on desired tunnel axis. A three-state dynamic model was established with considering unknown front face earth pressure force and unknown friction force. LuGre friction model was introduced to describe the friction force. Backstepping design was then proposed to make tracking error converge to zero. To have a comparison study, controller without LuGre model was designed. Tracking simulations of speed regulations and simulations when front face earth pressure changed were carried out to show the transient performances of the proposed controller. The results indicated that the controller had good tracking performance even under changing geological conditions. Experiments of speed regulations were carried out to have validations of the controllers.

  14. Adaptive backstepping control for levitation system with load uncertainties and external disturbances

    Institute of Scientific and Technical Information of China (English)

    李金辉; 李杰; 余佩; 王连春

    2014-01-01

    To explore the precise dynamic response of the levitation system with active controller, a maglev guide way-electromagnet-air spring-cabin coupled model is derived firstly. Based on the mathematical model, it shows that the inherent nonlinearity, inner coupling, misalignments between the sensors and actuators, load uncertainties and external disturbances are the main issues that should be solved in engineering. Under the assumptions that the loads and external disturbance are measurable, the backstepping module controller developed in this work can tackle the above problems effectively. In reality, the load is uncertain due to the additions of luggage and passengers, which will degrade the dynamic performance. A load estimation algorithm is introduced to track the actual load asymptotically and eliminate its influence by tuning the parameters of controller online. Furthermore, considering the external disturbances generated by crosswind, pulling motor and air springs, the extended state observer is employed to estimate and suppress the external disturbance. Finally, results of numerical simulations illustrating closed-loop performance are provided.

  15. Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer

    International Nuclear Information System (INIS)

    The aim of the thesis is to improve radiation plans of patients with locally advanced, unresectable pancreatic cancer by using carbon ion and proton beams. Using the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) a total of 50 treatment plans have been created for five patients with the dose schedule 15 × 3 Gy(RBE). With reference to the anatomy, five field configurations were considered to be relevant. The plans were analyzed with respect to dose distribution and individual anatomy, and compared using a customized index. Within the index the three-field configurations yielded the best results, though with a high variety of score points (field setup 5, carbon ion: median 74 (range 48–101)). The maximum dose in the myelon is low (e.g. case 3, carbon ion: 21.5 Gy(RBE)). A single posterior field generally spares the organs at risk, but the maximum dose in the myelon is high (e.g. case 3, carbon ion: 32.9 Gy(RBE)). Two oblique posterior fields resulted in acceptable maximum doses in the myelon (e.g. case 3, carbon ion: 26.9 Gy(RBE)). The single-field configuration and the two oblique posterior fields had a small score dispersion (carbon ion: median 66 and 58 (range 62–72 and 40–69)). In cases with topographic proximity of the organs at risk to the target volume, the single-field configuration scored as well as the three-field configurations. In summary, the three-field configurations showed the best dose distributions. A single posterior field seems to be robust and beneficial in case of difficult topographical conditions and topographical proximity of organs at risk to the target volume. A setup with two oblique posterior fields is a reasonable compromise between three-field and single-field configurations

  16. 一类带有未知控制方向的非线性系统的适应镇定问题%A Control of Uncertain Nonlinear Systems with Unknown Control Direction Via Adaptive Backstepping

    Institute of Scientific and Technical Information of China (English)

    郑兆顺

    2007-01-01

    The adaptive stabilization problem of nonlinear systems are studied. For a class of uncertain nonlinear systems with unknown control direction, we proposed a robust adaptive backstepping scheme with σ-modification by introducing Nussbaum function and Backstepping methods, and proved that all the signals of the closed-loop systems are bounded.

  17. Application of Adaptive Backstepping Sliding Mode Control in Alternative Current Servo System of Rocket Launcher%Application of Adaptive Backstepping Sliding Mode Control in Alternative Current Servo System of Rocket Launcher

    Institute of Scientific and Technical Information of China (English)

    郭亚军; 马大为; 王晓峰; 乐贵高

    2011-01-01

    An adaptive backstepping sliding mode control approach is introduced to control the pitch motion of a rocket launcher. Its control law is proposed to guarantee that the control system is ultimately bounded in a Lyapunov sense and make the servo system track the instruction of reference position globally and asymptotically. In addition, the sliding mode control can restrain the effects of parameter uncertainties and external disturbance. The functions of adaptive mechanism and sliding mode control are analyzed through the simulation in the different conditions. The simulation results illustrate that the method is applicable and robust.

  18. The relative biological effectiveness for carbon and oxygen ion beams using the raster-scanning technique in hepatocellular carcinoma cell lines.

    Directory of Open Access Journals (Sweden)

    Daniel Habermehl

    Full Text Available BACKGROUND: Aim of this study was to evaluate the relative biological effectiveness (RBE of carbon (12C and oxygen ion (16O-irradiation applied in the raster-scanning technique at the Heidelberg Ion beam Therapy center (HIT based on clonogenic survival in hepatocellular carcinoma cell lines compared to photon irradiation. METHODS: Four human HCC lines Hep3B, PLC, HepG2 and HUH7 were irradiated with photons, 12C and 16O using a customized experimental setting at HIT for in-vitro trials. Cells were irradiated with increasing physical photon single doses of 0, 2, 4 and 6 Gy and heavy ion-single doses of 0, 0.125, 0.5, 1, 2, 3 Gy (12C and 16O. SOBP-penetration depth and extension was 35 mm +/-4 mm and 36 mm +/-5 mm for carbon ions and oxygen ions respectively. Mean energy level and mean linear energy transfer (LET were 130 MeV/u and 112 keV/um for 12C, and 154 MeV/u and 146 keV/um for 16O. Clonogenic survival was computated and relative biological effectiveness (RBE values were defined. RESULTS: For all cell lines and both particle modalities α- and β-values were determined. As expected, α-values were significantly higher for 12C and 16O than for photons, reflecting a steeper decline of the initial slope of the survival curves for high-LET beams. RBE-values were in the range of 2.1-3.3 and 1.9-3.1 for 12C and 16O, respectively. CONCLUSION: Both irradiation with 12C and 16O using the raster-scanning technique leads to an enhanced RBE in HCC cell lines. No relevant differences between achieved RBE-values for 12C and 16O were found. Results of this work will further influence biological-adapted treatment planning for HCC patients that will undergo particle therapy with 12C or 16O.

  19. A General Response System Control Method Based on Backstepping Design for Synchronization of Continuous Scalar Chaotic Signal

    Institute of Scientific and Technical Information of China (English)

    WANG Jing; GAO Jin-Feng; MA Xi-Kui; LIANG Zhan-Hong

    2006-01-01

    @@ A general response system control method for synchronization of continuous scalar chaotic signal is presented. The proposed canonical general response system can cover most of the well-known chaotic systems. Conversely, each of these chaotic systems can also be used to construct the general response system. Furthermore, a novel controller of the proposed response system is designed based on backstepping technique, with which the output of the general response system and the given continuous chaotic signal can synchronize perfectly. Two numerical examples are given to illustrate the effectiveness of the proposed control method.

  20. Non-linear control of variable-speed wind turbines with permanent magnet synchronous generators: a robust backstepping approach

    Science.gov (United States)

    Şeker, Murat; Zergeroğlu, Erkan; Tatlicioğlu, Enver

    2016-01-01

    In this study, a robust backstepping approach for the control problem of the variable-speed wind turbine with a permanent magnet synchronous generator is presented. Specifically, to overcome the negative effects of parametric uncertainties in both mechanical and electrical subsystems, a robust controller with a differentiable compensation term is proposed. The proposed methodology ensures the generator velocity tracking error to uniformly approach a small bound where practical tracking is achieved. Stability of the overall system is ensured by Lyapunov-based arguments. Comparative simulation studies with a standard proportional-integral-type controller are performed to illustrate the effectiveness, feasibility and efficiency of the proposed controller.

  1. Carbon-Based Solid-State Calcium Ion-Selective Microelectrode and Scanning Electrochemical Microscopy: A Quantitative Study of pH-Dependent Release of Calcium Ions from Bioactive Glass.

    Science.gov (United States)

    Ummadi, Jyothir Ganesh; Downs, Corey J; Joshi, Vrushali S; Ferracane, Jack L; Koley, Dipankar

    2016-03-15

    Solid-state ion-selective electrodes are used as scanning electrochemical microscope (SECM) probes because of their inherent fast response time and ease of miniaturization. In this study, we report the development of a solid-state, low-poly(vinyl chloride), carbon-based calcium ion-selective microelectrode (Ca(2+)-ISME), 25 μm in diameter, capable of performing an amperometric approach curve and serving as a potentiometric sensor. The Ca(2+)-ISME has a broad linear response range of 5 μM to 200 mM with a near Nernstian slope of 28 mV/log[a(Ca(2+))]. The calculated detection limit for Ca(2+)-ISME is 1 μM. The selectivity coefficients of this Ca(2+)-ISME are log K(Ca(2+),A) = -5.88, -5.54, and -6.31 for Mg(2+), Na(+), and K(+), respectively. We used this new type of Ca(2+)-ISME as an SECM probe to quantitatively map the chemical microenvironment produced by a model substrate, bioactive glass (BAG). In acidic conditions (pH 4.5), BAG was found to increase the calcium ion concentration from 0.7 mM ([Ca(2+)] in artificial saliva) to 1.4 mM at 20 μm above the surface. In addition, a solid-state dual SECM pH probe was used to correlate the release of calcium ions with the change in local pH. Three-dimensional pH and calcium ion distribution mapping were also obtained by using these solid-state probes. The quantitative mapping of pH and Ca(2+) above the BAG elucidates the effectiveness of BAG in neutralizing and releasing calcium ions in acidic conditions. PMID:26861499

  2. Proton and carbon ion radiotherapy for primary brain tumors delivered with active raster scanning at the Heidelberg Ion Therapy Center (HIT: early treatment results and study concepts

    Directory of Open Access Journals (Sweden)

    Rieken Stefan

    2012-03-01

    Full Text Available Abstract Background Particle irradiation was established at the University of Heidelberg 2 years ago. To date, more than 400 patients have been treated including patients with primary brain tumors. In malignant glioma (WHO IV patients, two clinical trials have been set up-one investigating the benefit of a carbon ion (18 GyE vs. a proton boost (10 GyE in addition to photon radiotherapy (50 Gy, the other one investigating reirradiation with escalating total dose schedules starting at 30 GyE. In atypical meningioma patients (WHO °II, a carbon ion boost of 18 GyE is applied to macroscopic tumor residues following previous photon irradiation with 50 Gy. This study was set up in order to investigate toxicity and response after proton and carbon ion therapy for gliomas and meningiomas. Methods 33 patients with gliomas (n = 26 and meningiomas (n = 7 were treated with carbon ion (n = 26 and proton (n = 7 radiotherapy. In 22 patients, particle irradiation was combined with photon therapy. Temozolomide-based chemotherapy was combined with particle therapy in 17 patients with gliomas. Particle therapy as reirradiation was conducted in 7 patients. Target volume definition was based upon CT, MRI and PET imaging. Response was assessed by MRI examinations, and progression was diagnosed according to the Macdonald criteria. Toxicity was classified according to CTCAE v4.0. Results Treatment was completed and tolerated well in all patients. Toxicity was moderate and included fatigue (24.2%, intermittent cranial nerve symptoms (6% and single episodes of seizures (6%. At first and second follow-up examinations, mean maximum tumor diameters had slightly decreased from 29.7 mm to 27.1 mm and 24.9 mm respectively. Nine glioma patients suffered from tumor relapse, among these 5 with infield relapses, causing death in 8 patients. There was no progression in any meningioma patient. Conclusions Particle radiotherapy is safe and feasible in patients with primary brain

  3. Argon broad ion beam tomography in a cryogenic scanning electron microscope: a novel tool for the investigation of representative microstructures in sedimentary rocks containing pore fluid.

    Science.gov (United States)

    Desbois, G; Urai, J L; Pérez-Willard, F; Radi, Z; Offern, S; Burkart, I; Kukla, P A; Wollenberg, U

    2013-03-01

    The contribution describes the implementation of a broad ion beam (BIB) polisher into a scanning electron microscope (SEM) functioning at cryogenic temperature (cryo). The whole system (BIB-cryo-SEM) provides a first generation of a novel multibeam electron microscope that combines broad ion beam with cryogenic facilities in a conventional SEM to produce large, high-quality cross-sections (up to 2 mm(2)) at cryogenic temperature to be imaged at the state-of-the-art SEM resolution. Cryogenic method allows detecting fluids in their natural environment and preserves samples against desiccation and dehydration, which may damage natural microstructures. The investigation of microstructures in the third dimension is enabled by serial cross-sectioning, providing broad ion beam tomography with slices down to 350 nm thick. The functionalities of the BIB-cryo-SEM are demonstrated by the investigation of rock salts (synthetic coarse-grained sodium chloride synthesized from halite-brine mush cold pressed at 150 MPa and 4.5 GPa, and natural rock salt mylonite from a salt glacier at Qom Kuh, central Iran). In addition, results from BIB-cryo-SEM on a gas shale and Boom Clay are also presented to show that the instrument is suitable for a large range of sedimentary rocks. For the first time, pore and grain fabrics of preserved host and reservoir rocks can be investigated at nm-scale range over a representative elementary area. In comparison with the complementary and overlapping performances of the BIB-SEM method with focused ion beam-SEM and X-ray tomography methods, the BIB cross-sectioning enables detailed insights about morphologies of pores at greater resolution than X-ray tomography and allows the production of large representative surfaces suitable for FIB-SEM investigations of a specific representative site within the BIB cross-section. PMID:23323728

  4. Rapid screening and identification of target constituents using full scan-parent ions list-dynamic exclusion acquisition coupled to diagnostic product ions analysis on a hybrid LTQ-Orbitrap mass spectrometer.

    Science.gov (United States)

    Zhang, Jia-Yu; Wang, Zi-Jian; Zhang, Qian; Wang, Fang; Ma, Qun; Lin, Zhao-Zhou; Lu, Jian-Qiu; Qiao, Yan-Jiang

    2014-06-01

    A highly sensitive and effective strategy for rapid screening and identification of target constituents has been developed using full scan-parent ions list-dynamic exclusion (FS-PIL-DE) acquisition coupled to diagnostic product ions (DPIs) analysis on a hybrid LTQ-Orbitrap mass spectrometer. The FS-PIL-DE was adopted as a survey scan to trigger the MS/MS acquisition of all the predictable constituents contained in traditional Chinese medicines. Additionally, DPIs analysis can provide a criterion to judge the target constituents detected into certain chemical families. Results from analyzing polymethoxylated flavonoids (PMFs) in the leaves of Citrus reticulata Blanco demonstrated that FS-PIL-DE was capable of targeting a greater number of constituents than FS, FS-PIL and FS-DE, thereby increasing the coverage of constituent screening. As a result, 135 PMFs including 81 polymethoxyflavones, 54 polymethoxyflavanones or polymethoxychalcones were identified preliminarily. And this was the first time to systematically report the presence of PMFs in the leaves of Citrus reticulata Blanco, especially for polymethoxylated flavanones and chalcones, most of which were new compounds. The results indicated that the developed FS-PIL-DE coupled to DPIs analysis methodology could be employed as a rapid, effective technique to screen and identify target constituents from TCMs extracts and other organic matter mixtures whose compounds contained can also be classified into families based on the common carbon skeletons. PMID:24767453

  5. Detection and cartography of the fluorinated antimalarial drug mefloquine in normal and Plasmodium falciparum infected red blood cells by scanning ion microscopy and mass spectrometry.

    Science.gov (United States)

    Adovelande, J; Boulard, Y; Berry, J P; Galle, P; Slodzian, G; Schrével, J

    1994-01-01

    Due to the presence of fluorine atoms in its molecule, the antimalarial drug mefloquine (MQ) can be easily detected in normal and Plasmodium falciparum infected red blood cells (RBC) by scanning ion microscopy and mass spectrometry. The P falciparum infected RBC exhibited intense distribution of MQ inside the parasite. The main compartments of the parasite which accumulate the drug were the food vacuole and the cytoplasm. The correlation between fluorine (19F-) and phosphorus (31P-) as well as probes for the DNA synthesis (BrdU and IdU) emissions shows that the parasite nucleus is also accessible to the drug. This study demonstrates that SIMS technique on smear preparations is an efficient approach for the direct detection and cartography of fluorinated antimalarial drugs in normal and P falciparum infected RBC, without radioactive labelling.

  6. Qualitative and Quantitative Characterization of Porosity in a Low Porous and Low Permeable Organic Rich Shale by Combining Broad Ion Beam and Scanning Electron Microscopy (BIB-SEM)

    International Nuclear Information System (INIS)

    This contribution focuses on the characterization of porosity in low porous shale using a broad ion beam (BIB) polishing technique combined with a conventional scanning electron microscopy (SEM). Porosity was traced in certain representative elementary areas (REA) and pores detected are segmented from mosaics of secondary electron (SE) images. Traced pores could be classified into two major pore-size classes. Relative large pores (> 0.5 μm2) were found in the organic matter and matrix. They contribute strongly to the overall porosity con-tent of the shale. Nevertheless the far majority of the pores traced have equivalent radius less than 400 nm. Including the latter pore class, the imaged porosity from both samples gives similar results in the order of < 1 %. (authors)

  7. Direct observation of the spatial distribution of samarium ions in alumina-silica macroporous monoliths by laser scanning confocal microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Murai, Shunsuke [Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan); Fujita, Koji [Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan)]. E-mail: fujita@sung7.kuic.kyoto-u.ac.jp; Nakanishi, Kazuki [Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan); Hirao, Kazuyuki [Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510 (Japan)

    2006-02-09

    We have investigated the spatial distribution of Sm{sup 2+} inside macroporous alumina-silica (Al{sub 2}O{sub 3}-SiO{sub 2}) glasses having three-dimensionally interconnected skeletons. The Sm{sup 2+}-doped Al{sub 2}O{sub 3}-SiO{sub 2} glasses are prepared via an alkoxy-derived sol-gel route in the presence of poly (ethylene oxide) and SmCl{sub 3}.6H{sub 2}O. The well-defined macroporous morphology is obtained by the concurrence of the phase separation and the sol-gel transition. The reduction of Sm{sup 3+} to Sm{sup 2+} is accomplished by heat treatment under a reducing atmosphere. Two-dimensional images of the fluorescence due to the 4f-4f transition of Sm{sup 2+} with the aid of a laser scanning confocal microscope reveal the spatially uniform dispersion of Sm{sup 2+} inside the Al{sub 2}O{sub 3}-SiO{sub 2} skeleton.

  8. Core - Corona Model analysis of the Low Energy Beam Scan at RHIC (Relativistic Heavy Ion Collider) in Brookhaven (USA)

    CERN Document Server

    Gemard, M

    2014-01-01

    The centrality dependence of spectra of identified particles in collisions between ultrarelativistic heavy ions with a center of mass energy ($\\sqrt{s}$) of 39 and 11.5 $AGeV$ is analyzed in the core - corona model. We show that at these energies the spectra can be well understood assuming that they are composed of two components whose relative fraction depends on the centrality of the interaction: The core component which describes an equilibrated quark gluon plasma and the corona component which is caused by nucleons close to the surface of the interaction zone which scatter only once and which is identical to that observed in proton-proton collisions. The success of this approach at 39 and 11.5 $AGeV$ shows that the physics does not change between this energy and $\\sqrt{s}=200~ AGeV$ for which this model has been developed (Aichelin 2008). This presents circumstantial evidence that a quark gluon plasma is also created at center of mass energies as low as 11.5 $AGeV$.

  9. In situ scanning tunneling microscopy studies of the SEI formation on graphite electrodes for Li+-ion batteries

    Science.gov (United States)

    Seidl, Lukas; Martens, Slađana; Ma, Jiwei; Stimming, Ulrich; Schneider, Oliver

    2016-07-01

    The SEI-formation on graphitic electrodes operated as an Li+-ion battery anode in a standard 1 M LiPF6 EC/DMC (1 : 1) electrolyte has been studied in situ by EC-STM. Two different modes of in situ study were applied, one, which allowed to follow topographic and crystallographic changes (solvent cointercalation, graphite exfoliation, SEI precipitation on the HOPG basal plane) of the graphite electrode during SEI-formation, and the second, which gave an insight into the SEI precipitation on the HOPG basal plane in real time. From the in situ EC-STM studies, not only conclusions about the SEI-topography could be drawn, but also about the formation mechanism and the chemical composition, which strongly depend on the electrode potential. It was shown that above 1.0 V vs. Li/Li+ the SEI-formation is still reversible, since the molecular structure of the solvent molecules remains intact during an initial reduction step. During further reduction, the molecular structures of the solvents are destructed, which causes the irreversible charge loss. The STM studies were completed by electrochemical methods, like cyclic voltammetry, the potentiostatic intermittent titration technique and charge/discharge tests of MCMB electrodes.

  10. Nuclear Scans

    Science.gov (United States)

    Nuclear scans use radioactive substances to see structures and functions inside your body. They use a special ... images. Most scans take 20 to 45 minutes. Nuclear scans can help doctors diagnose many conditions, including ...

  11. Adaptive-backstepping force/motion control for mobile-manipulator robot based on fuzzy CMAC neural networks

    Institute of Scientific and Technical Information of China (English)

    Thang-Long MAI; Yaonan WANG

    2014-01-01

    In this paper, an adaptive backstepping fuzzy cerebellar-model-articulation-control neural-networks control (ABFCNC) system for motion/force control of the mobile-manipulator robot (MMR) is proposed. By applying the ABFCNC in the tracking-position controller, the unknown dynamics and parameter variation problems of the MMR control system are relaxed. In addition, an adaptive robust compensator is proposed to eliminate uncertainties that consist of approximation errors, uncertain disturbances. Based on the tracking position-ABFCNC design, an adaptive robust control strategy is also developed for the nonholonomic-constraint force of the MMR. The design of adaptive-online learning algorithms is obtained by using the Lyapunov stability theorem. Therefore, the proposed method proves that it not only can guarantee the stability and robustness but also the tracking performances of the MMR control system. The effectiveness and robustness of the proposed control system are verified by comparative simulation results.

  12. Scanning transmission ion microscopy mass measurements for quantitative trace element analysis within biological samples and validation using atomic force microscopy thickness measurements

    Science.gov (United States)

    Devès, Guillaume; Cohen-Bouhacina, Touria; Ortega, Richard

    2004-10-01

    We used the nuclear microprobe techniques, micro-PIXE (particle-induced X-ray emission), micro-RBS (Rutherford backscattering spectrometry) and scanning transmission ion microscopy (STIM) in order to perform the characterization of trace element content and spatial distribution within biological samples (dehydrated cultured cells, tissues). The normalization of PIXE results was usually expressed in terms of sample dry mass as determined by micro-RBS recorded simultaneously to micro-PIXE. However, the main limit of RBS mass measurement is the sample mass loss occurring during irradiation and which could be up to 30% of the initial sample mass. We present here a new methodology for PIXE normalization and quantitative analysis of trace element within biological samples based on dry mass measurement performed by mean of STIM. The validation of STIM cell mass measurements was obtained in comparison with AFM sample thickness measurements. Results indicated the reliability of STIM mass measurement performed on biological samples and suggested that STIM should be performed for PIXE normalization. Further information deriving from direct confrontation of AFM and STIM analysis could as well be obtained, like in situ measurements of cell specific gravity within cells compartment (nucleolus and cytoplasm).

  13. Scanning transmission ion microscopy mass measurements for quantitative trace element analysis within biological samples and validation using atomic force microscopy thickness measurements

    Energy Technology Data Exchange (ETDEWEB)

    Deves, Guillaume [Laboratoire de chimie nucleaire analytique et bioenvironnementale, UMR 5084, CNRS-Universite de Bordeaux 1, BP 120 Chemin du solarium, F33175 Gradignan cedex (France)]. E-mail: deves@cenbg.in2p3.fr; Cohen-Bouhacina, Touria [Centre de Physique Moleculaire Optique et Hertzienne, Universite de Bordeaux 1, 351, cours de la Liberation, F33405 Talence cedex (France); Ortega, Richard [Laboratoire de chimie nucleaire analytique et bioenvironnementale, UMR 5084, CNRS-Universite de Bordeaux 1, BP 120 Chemin du solarium, F33175 Gradignan cedex (France)

    2004-10-08

    We used the nuclear microprobe techniques, micro-PIXE (particle-induced X-ray emission), micro-RBS (Rutherford backscattering spectrometry) and scanning transmission ion microscopy (STIM) in order to perform the characterization of trace element content and spatial distribution within biological samples (dehydrated cultured cells, tissues). The normalization of PIXE results was usually expressed in terms of sample dry mass as determined by micro-RBS recorded simultaneously to micro-PIXE. However, the main limit of RBS mass measurement is the sample mass loss occurring during irradiation and which could be up to 30% of the initial sample mass. We present here a new methodology for PIXE normalization and quantitative analysis of trace element within biological samples based on dry mass measurement performed by mean of STIM. The validation of STIM cell mass measurements was obtained in comparison with AFM sample thickness measurements. Results indicated the reliability of STIM mass measurement performed on biological samples and suggested that STIM should be performed for PIXE normalization. Further information deriving from direct confrontation of AFM and STIM analysis could as well be obtained, like in situ measurements of cell specific gravity within cells compartment (nucleolus and cytoplasm)

  14. Development and implementation of scanning ion conductance microscope%扫描离子电导显微镜的研制与实现

    Institute of Scientific and Technical Information of China (English)

    李鹏; 张常麟; 王文学; 刘连庆

    2014-01-01

    High- resolution imaging of living cell at the micro- /nano- scale is important for life science research. It may help to observe biological activities of cells, and to detect cell responses to external stimuli and even movements of some protein molecules in cell membranes. However, there have not been effective methods to realize such objectives yet. Scanning ion conductance microscope (SICM) has been widely applied in many fields and is receiving increasing attention due to its non- contact, force- free, and high- resolution imaging features. Herein, a design of SICM, including hardware integration and scanning algorithms, was introduced from the point of view of system firstly; then the feasibility and effectiveness of the system was evaluated through comparison of PDMS gratings measurements by SICM and AFM;finally, in situ experiments of living- cell imaging in physiological environment had been carried out, and the topography of living neuro- 2A cell had been successfully obtained. The well- established scanning ion conductance microscope will provide an effective tool for investigating functional mechanism and micro-structure on the surface of living biological samples.%在微纳米尺度上对活细胞高分辨率成像对生命科学研究具有重要的意义,其将有助于再现正在发生的生命过程、检测细胞对外界刺激做出的响应,甚至观测某些蛋白簇在细胞膜表面的运动。然而直到今天,仍然没有很好的实现上述目标。扫描离子电导显微镜(SICM)由于其真正的非接触、高分辨、无损独特成像方式,规避了扫描过程中探针与样品表面发生力的接触,得到越来越多的关注和广泛的应用。从系统的角度阐述自制SICM系统的设计、硬件集成及跳跃模式扫描算法的实现,并通过对聚二甲基硅氧烷(PDMS)栅格成像以及与原子力显微镜(AFM)成像结果的对比,验证了系统功能的正确性和有效性;最后开展了

  15. Comparison of backstepping and modified active control in projective synchronization of chaos in an extended Bonhöffer–van der Pol oscillator

    Indian Academy of Sciences (India)

    K S Ojo; A N Njah; S T Ogunjo

    2013-05-01

    In this article, projective synchronization of double–scroll attractor of an extended Bonöffer–van der Pol oscillator (BVPO) is considered via the backstepping and active control techniques. In each synchronization scheme, a single control function is designed to achieve projective synchronization between two Bonhöffer–van der Pol oscillator evolving from different initial conditions. To obtain a single control function via the active control, the coefficient of the error dynamics is chosen such that the number of control functions is reduced from three to one, thereby, reducing control function complexity in design. The results show that the transient error dynamics convergence and synchronization time are achieved faster via the backstepping than that of the active control technique. However, the control function obtained via the active control is simpler with a more stable synchronization time and hence, it is more suitable for practical implementation. Numerical simulations are presented to confirm the effectiveness of the analytical results.

  16. Global Harmonic Current Rejection of Nonlinear Backstepping Control with Multivariable Adaptive Internal Model Principle for Grid-Connected Inverter under Distorted Grid Voltage

    Directory of Open Access Journals (Sweden)

    Yang Yu

    2013-01-01

    Full Text Available Based on a brief review on current harmonics generation mechanism for grid-connected inverter under distorted grid voltage, the harmonic disturbances and uncertain items are immersed into the original state-space differential equation of grid-connected inverter. A new algorithm of global current harmonic rejection based on nonlinear backstepping control with multivariable internal model principle is proposed for grid-connected inverter with exogenous disturbances and uncertainties. A type of multivariable internal model for a class of nonlinear harmonic disturbances is constructed. Based on application of backstepping control law of the nominal system, a multivariable adaptive state feedback controller combined with multivariable internal model and adaptive control law is designed to guarantee the closed-loop system globally uniformly bounded, which is proved by a constructed Lyapunov function. The presented algorithm extends rejection of nonlinear single-input systems to multivariable globally defined normal form, the correctness and effectiveness of which are verified by the simulation results.

  17. Application of Backstepping to the Virtual Flux Direct Power Control of Five-Level Three-Phase Shunt Active Power Filter

    Directory of Open Access Journals (Sweden)

    Bouzidi Mansour

    2014-03-01

    Full Text Available This paper proposes a virtual flux direct power control-space vector modulation combined with backstepping control for three-phase five-level neutral point clamped shunt active power filter. The main goal of the proposed active filtering system is to eliminate the unwanted harmonics and compensate fundamental reactive power drawn from the nonlinear loads. In this study, the voltage-balancing control of four split dc capacitors of the five-level active filter is achieved using five-level space vector modulation with balancing strategy based on the effective use of the redundant switching states of the inverter voltage vectors. The obtained results showed that, the proposed multilevel shunt active power filter with backstepping control can produce a sinusoidal supply current with low harmonic distortion and in phase with the line voltage.

  18. Carbon-ion scanning lung treatment planning with respiratory-gated phase-controlled rescanning: simulation study using 4-dimensional CT data

    International Nuclear Information System (INIS)

    To moving lung tumors, we applied a respiratory-gated strategy to carbon-ion pencil beam scanning with multiple phase-controlled rescanning (PCR). In this simulation study, we quantitatively evaluated dose distributions based on 4-dimensional CT (4DCT) treatment planning. Volumetric 4DCTs were acquired for 14 patients with lung tumors. Gross tumor volume, clinical target volume (CTV) and organs at risk (OARs) were delineated. Field-specific target volumes (FTVs) were calculated, and 48Gy(RBE) in a single fraction was prescribed to the FTVs delivered from four beam angles. The dose assessment metrics were quantified by changing the number of PCR and the results for the ungated and gated scenarios were then compared. For the ungated strategy, the mean dose delivered to 95% of the volume of the CTV (CTV-D95) was in average 45.3 ± 0.9 Gy(RBE) even with a single rescanning (1 × PCR). Using 4 × PCR or more achieved adequate target coverage (CTV-D95 = 46.6 ± 0.3 Gy(RBE) for ungated 4 × PCR) and excellent dose homogeneity (homogeneity index =1.0 ± 0.2% for ungated 4 × PCR). Applying respiratory gating, percentage of lung receiving at least 20 Gy(RBE) (lung-V20) and heart maximal dose, averaged over all patients, significantly decreased by 12% (p < 0.05) and 13% (p < 0.05), respectively. Four or more PCR during PBS-CIRT improved dose conformation to moving lung tumors without gating. The use of a respiratory-gated strategy in combination with PCR reduced excessive doses to OARs

  19. Characterization of stainless steel through Scanning Electron Microscopy, nitrided in the process of implantation of immersed ions in plasma; Caracterizacion de acero inoxidable mediante Microscopia Electronica de Barrido nitrurado en el proceso de implantacion de iones inmersos en plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Moreno S, H

    2003-07-01

    The present project carries out the investigation of the nitridation of the austenitic stainless steel schedule 304, applying the novel technology of installation of nitrogen ions in immersed materials in plasma (Plll), by means of which they modify those properties of the surface of the steel. The obtained results by means of tests of Vickers microhardness, shows that the hardness was increment from 266 to 740 HV (microhardness units). It was determined by means of scanning electron microscopy, the one semiquantitative chemical analysis of the elements that constitute the austenitic stainless steel schedule 304; the obtained results, show to the nitrogen like an element of their composition in the pieces where carried out to end the PIII technology. The parameters of the plasma with which carried out the technology Plll, were monitored and determined by means of electric probes, and with which it was determined that the density of particles is stable in the interval of 1x10{sup -1} at 3x10{sup -1}Torr, and it is where better results of hardness were obtained. That reported in this work, they are the first results obtained when applying the technology Plll in Mexico, and with base in these, it is even necessary to investigate and to deepen until to dominate the process and to be in possibilities of proposing it to be carried out and exploited in an industrial way. (Author)

  20. CT Scans

    Science.gov (United States)

    ... cross-sectional pictures of your body. Doctors use CT scans to look for Broken bones Cancers Blood clots Signs of heart disease Internal bleeding During a CT scan, you lie still on a table. The table ...

  1. Thyroid scan

    Science.gov (United States)

    ... PET scan Skin nodules Thyroid cancer Thyroid cancer - medullary carcinoma Thyroid cancer - papillary carcinoma Toxic nodular goiter ... Topics Hyperthyroidism Hypothyroidism Nuclear Scans Thyroid Cancer Thyroid Diseases Thyroid Tests Browse the Encyclopedia A.D.A. ...

  2. SU-C-303-06: Treatment Planning Study for Non-Invasive Cardiac Arrhythmia Ablation with Scanned Carbon Ions in An Animal Model

    Energy Technology Data Exchange (ETDEWEB)

    Eichhorn, A; Constantinescu, A; Prall, M; Kaderka, R; Durante, M; Graeff, C [GSI Helmholtz Center, Darmstadt, DE (Germany); Lehmann, H I; Takami, M; Packer, D L [Mayo Clinic, Rochester, Minnesota (United States); Lugenbiel, P; Thomas, D [University of Heidelberg, Heidelberg, DE (Germany); Richter, D; Bert, C [University Clinic Erlangen, Erlagen, DE (Germany)

    2015-06-15

    Purpose: Scanned carbon ion beams might offer a non-invasive alternative treatment for cardiac arrhythmia, which are a major health-burden. We studied the feasibility of this procedure in an animal model. The underlying treatment planning and motion mitigation strategies will be presented. Methods: The study was carried out in 15 pigs, randomly distributed to 3 target groups: atrioventricular node (AVN, 8 animals with 25, 40, and 55 Gy target dose), left ventricular free-wall (LV, 4 animals with 40 Gy) and superior pulmonary vein (SPV, 3 animals with 40 Gy). Breathing motion was suppressed by repeated enforced breathholds at end exhale. Cardiac motion was mitigated by an inhomogeneous rescanning scheme with up to 15 rescans. The treatment planning was performed using the GSI in-house software TRiP4D on cardiac-gated 4DCTs, applying a range-considering ITV based on an extended CTV. For AVN and SPV isotropic 5 mm margins were applied to the CTV, while for the LV 2mm+2% range margins were used. The opposing fields for AVN and LV targets were optimized independently (SFUD), while SPV treatments were optimized as IMPT deliveries, including dose restrictions to the radiosensitive AVN. Results: Median value of D{sub 95} over all rescanning simulations was 99.1% (AVN), 98.0% (SPV) and 98.3% (LV) for the CTV and 94.7% (AVN) and 92.7% (SPV) for the PTV, respectively. The median D{sub 5}-D{sub 95} was improved with rescanning compared to unmitigated delivery from 13.3 to 6.5% (CTV) and from 23.4 to 11.6% (PTV). ICRP dose limits for aorta, trachea, esophagus and skin were respected. The maximal dose in the coronary arteries was limited to 30 Gy. Conclusion: We demonstrated the feasibility of a homogeneous dose delivery to different cardiac structures in a porcine model using a time-optimized inhomogeneous rescanning scheme. The presented treatment planning strategies were applied in a pig study with the analysis ongoing. Funding: This work was supported in part by the

  3. SU-C-303-06: Treatment Planning Study for Non-Invasive Cardiac Arrhythmia Ablation with Scanned Carbon Ions in An Animal Model

    International Nuclear Information System (INIS)

    Purpose: Scanned carbon ion beams might offer a non-invasive alternative treatment for cardiac arrhythmia, which are a major health-burden. We studied the feasibility of this procedure in an animal model. The underlying treatment planning and motion mitigation strategies will be presented. Methods: The study was carried out in 15 pigs, randomly distributed to 3 target groups: atrioventricular node (AVN, 8 animals with 25, 40, and 55 Gy target dose), left ventricular free-wall (LV, 4 animals with 40 Gy) and superior pulmonary vein (SPV, 3 animals with 40 Gy). Breathing motion was suppressed by repeated enforced breathholds at end exhale. Cardiac motion was mitigated by an inhomogeneous rescanning scheme with up to 15 rescans. The treatment planning was performed using the GSI in-house software TRiP4D on cardiac-gated 4DCTs, applying a range-considering ITV based on an extended CTV. For AVN and SPV isotropic 5 mm margins were applied to the CTV, while for the LV 2mm+2% range margins were used. The opposing fields for AVN and LV targets were optimized independently (SFUD), while SPV treatments were optimized as IMPT deliveries, including dose restrictions to the radiosensitive AVN. Results: Median value of D95 over all rescanning simulations was 99.1% (AVN), 98.0% (SPV) and 98.3% (LV) for the CTV and 94.7% (AVN) and 92.7% (SPV) for the PTV, respectively. The median D5-D95 was improved with rescanning compared to unmitigated delivery from 13.3 to 6.5% (CTV) and from 23.4 to 11.6% (PTV). ICRP dose limits for aorta, trachea, esophagus and skin were respected. The maximal dose in the coronary arteries was limited to 30 Gy. Conclusion: We demonstrated the feasibility of a homogeneous dose delivery to different cardiac structures in a porcine model using a time-optimized inhomogeneous rescanning scheme. The presented treatment planning strategies were applied in a pig study with the analysis ongoing. Funding: This work was supported in part by the Helmholtz Association, the

  4. Global Profiling and Novel Structure Discovery Using Multiple Neutral Loss/Precursor Ion Scanning Combined with Substructure Recognition and Statistical Analysis (MNPSS): Characterization of Terpene-Conjugated Curcuminoids in Curcuma longa as a Case Study.

    Science.gov (United States)

    Qiao, Xue; Lin, Xiong-hao; Ji, Shuai; Zhang, Zheng-xiang; Bo, Tao; Guo, De-an; Ye, Min

    2016-01-01

    To fully understand the chemical diversity of an herbal medicine is challenging. In this work, we describe a new approach to globally profile and discover novel compounds from an herbal extract using multiple neutral loss/precursor ion scanning combined with substructure recognition and statistical analysis. Turmeric (the rhizomes of Curcuma longa L.) was used as an example. This approach consists of three steps: (i) multiple neutral loss/precursor ion scanning to obtain substructure information; (ii) targeted identification of new compounds by extracted ion current and substructure recognition; and (iii) untargeted identification using total ion current and multivariate statistical analysis to discover novel structures. Using this approach, 846 terpecurcumins (terpene-conjugated curcuminoids) were discovered from turmeric, including a number of potentially novel compounds. Furthermore, two unprecedented compounds (terpecurcumins X and Y) were purified, and their structures were identified by NMR spectroscopy. This study extended the application of mass spectrometry to global profiling of natural products in herbal medicines and could help chemists to rapidly discover novel compounds from a complex matrix.

  5. Back-stepping active disturbance rejection control design for integrated missile guidance and control system via reduced-order ESO.

    Science.gov (United States)

    Xingling, Shao; Honglun, Wang

    2015-07-01

    This paper proposes a novel composite integrated guidance and control (IGC) law for missile intercepting against unknown maneuvering target with multiple uncertainties and control constraint. First, by using back-stepping technique, the proposed IGC law design is separated into guidance loop and control loop. The unknown target maneuvers and variations of aerodynamics parameters in guidance and control loop are viewed as uncertainties, which are estimated and compensated by designed model-assisted reduced-order extended state observer (ESO). Second, based on the principle of active disturbance rejection control (ADRC), enhanced feedback linearization (FL) based control law is implemented for the IGC model using the estimates generated by reduced-order ESO. In addition, performance analysis and comparisons between ESO and reduced-order ESO are examined. Nonlinear tracking differentiator is employed to construct the derivative of virtual control command in the control loop. Third, the closed-loop stability for the considered system is established. Finally, the effectiveness of the proposed IGC law in enhanced interception performance such as smooth interception course, improved robustness against multiple uncertainties as well as reduced control consumption during initial phase are demonstrated through simulations. PMID:25776190

  6. Back-stepping active disturbance rejection control design for integrated missile guidance and control system via reduced-order ESO.

    Science.gov (United States)

    Xingling, Shao; Honglun, Wang

    2015-07-01

    This paper proposes a novel composite integrated guidance and control (IGC) law for missile intercepting against unknown maneuvering target with multiple uncertainties and control constraint. First, by using back-stepping technique, the proposed IGC law design is separated into guidance loop and control loop. The unknown target maneuvers and variations of aerodynamics parameters in guidance and control loop are viewed as uncertainties, which are estimated and compensated by designed model-assisted reduced-order extended state observer (ESO). Second, based on the principle of active disturbance rejection control (ADRC), enhanced feedback linearization (FL) based control law is implemented for the IGC model using the estimates generated by reduced-order ESO. In addition, performance analysis and comparisons between ESO and reduced-order ESO are examined. Nonlinear tracking differentiator is employed to construct the derivative of virtual control command in the control loop. Third, the closed-loop stability for the considered system is established. Finally, the effectiveness of the proposed IGC law in enhanced interception performance such as smooth interception course, improved robustness against multiple uncertainties as well as reduced control consumption during initial phase are demonstrated through simulations.

  7. MRI Scans

    Science.gov (United States)

    Magnetic resonance imaging (MRI) uses a large magnet and radio waves to look at organs and structures inside your body. Health care professionals use MRI scans to diagnose a variety of conditions, from ...

  8. CT scan

    Science.gov (United States)

    ... come from a CT scan. Some people have allergies to contrast dye. Let your doctor know if you have ... vein contains iodine. If you have an iodine allergy, a type of contrast may cause nausea or vomiting , sneezing , itching , or ...

  9. Linking the microstructure, performance and durability of Ni-yttria-stabilized zirconia solid oxide fuel cell anodes using three-dimensional focused ion beam-scanning electron microscopy imaging

    International Nuclear Information System (INIS)

    In this work we demonstrate the utility of three-dimensional focused ion beam-scanning electron microscopy nanotomography for understanding composite electrode performance and degradation. Phase connectivity, electrochemically active triple-phase boundary density and phase tortuosity are calculated for a series of anodes with varying Ni-YSZ composition. These structural characteristics, achievable only through three-dimensional interrogation, are shown to play a vital role in determining electrode polarization resistance. Additionally, Ni-YSZ samples are experimentally annealed in hydrogen and reconstructed to quantitatively assess degradation as a function of reduced triple-phase boundary density.

  10. Energy Scan program

    Directory of Open Access Journals (Sweden)

    Poniatowska Katarzyna M.

    2014-04-01

    Full Text Available Femtoscopy of two non-identical particles in heavy ion collisions enables one to study the space-time asymmetry in the particle's emission process. Theoretical studies based on EPOS model performed for collision energies from the Beam Energy Scan program in STAR allow us to investigate the dependence of source sizes and dynamics effects. Obtained information will enable us to predict the collective behaviour of femtoscopic particle's source.

  11. A novel algorithm for the calculation of physical and biological irradiation quantities in scanned ion beam therapy: the beamlet superposition approach

    Science.gov (United States)

    Russo, G.; Attili, A.; Battistoni, G.; Bertrand, D.; Bourhaleb, F.; Cappucci, F.; Ciocca, M.; Mairani, A.; Milian, F. M.; Molinelli, S.; Morone, M. C.; Muraro, S.; Orts, T.; Patera, V.; Sala, P.; Schmitt, E.; Vivaldo, G.; Marchetto, F.

    2016-01-01

    The calculation algorithm of a modern treatment planning system for ion-beam radiotherapy should ideally be able to deal with different ion species (e.g. protons and carbon ions), to provide relative biological effectiveness (RBE) evaluations and to describe different beam lines. In this work we propose a new approach for ion irradiation outcomes computations, the beamlet superposition (BS) model, which satisfies these requirements. This model applies and extends the concepts of previous fluence-weighted pencil-beam algorithms to quantities of radiobiological interest other than dose, i.e. RBE- and LET-related quantities. It describes an ion beam through a beam-line specific, weighted superposition of universal beamlets. The universal physical and radiobiological irradiation effect of the beamlets on a representative set of water-like tissues is evaluated once, coupling the per-track information derived from FLUKA Monte Carlo simulations with the radiobiological effectiveness provided by the microdosimetric kinetic model and the local effect model. Thanks to an extension of the superposition concept, the beamlet irradiation action superposition is applicable for the evaluation of dose, RBE and LET distributions. The weight function for the beamlets superposition is derived from the beam phase space density at the patient entrance. A general beam model commissioning procedure is proposed, which has successfully been tested on the CNAO beam line. The BS model provides the evaluation of different irradiation quantities for different ions, the adaptability permitted by weight functions and the evaluation speed of analitical approaches. Benchmarking plans in simple geometries and clinical plans are shown to demonstrate the model capabilities.

  12. Dynamic modeling of a hose-drogue aerial refueling system and integral sliding mode backstepping control for the hose whipping phenomenon

    Institute of Scientific and Technical Information of China (English)

    Wang Haitao; Dong Xinmin; Xue Jianping; Liu Jiaolong

    2014-01-01

    Dynamic modeling of a hose-drogue aerial refueling system (HDARS) and an integral sliding mode backstepping controller design for the hose whipping phenomenon (HWP) during probe-drogue coupling are studied. Firstly, a dynamic model of the variable-length hose-drogue assembly is built for the sake of exploiting suppression methods for the whipping phenomenon. Based on the lumped parameter method, the hose is modeled by a series of variable-length links connected with frictionless joints. A set of iterative equations of the hose’s three-dimensional motion is derived subject to hose reeling in/out, tanker motion, gravity, and aerodynamic loads accounting for the effects of steady wind, atmospheric turbulence, and tanker wake. Secondly, relying on a permanent magnet synchronous motor and high-precision position sensors, a new active control strategy for the HWP on the basis of the relative position between the tanker and the receiver is proposed. Considering the strict-feedback configuration of the permanent magnet synchronous motor, a rotor position control law based on the backstepping method is designed to insure global stability. An integral of the rotor position error and an exponential sliding mode reaching law of the current errors are applied to enhance control accuracy and robustness. Finally, the simulation results show the effectiveness of the proposed model and control laws.

  13. Scan Statistics

    CERN Document Server

    Glaz, Joseph

    2009-01-01

    Suitable for graduate students and researchers in applied probability and statistics, as well as for scientists in biology, computer science, pharmaceutical science and medicine, this title brings together a collection of chapters illustrating the depth and diversity of theory, methods and applications in the area of scan statistics.

  14. Perineal scanning.

    Science.gov (United States)

    Jeanty, P; d'Alton, M; Romero, R; Hobbins, J C

    1986-10-01

    Although various techniques have been described to aid in the ultrasound diagnosis of placenta previa and incompetent cervix, these maneuvers depend on the precise identification of the internal cervical os, a feat which is notoriously difficult to accomplish consistently. In an attempt to get a closer view of the cervix we tried another approach. This simple technique of perineal scanning has the potential to help considerably with these problems. PMID:3530265

  15. Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: A tool for monitoring PE metabolism

    DEFF Research Database (Denmark)

    Bilgin, Mesut; Markgraf, Daniel F; Duchoslav, Eva;

    2011-01-01

    We report a method for the simultaneous identification and quantification of phosphatidylethanolamine (PE), monomethyl-phosphatidylethanolamine (MMPE), dimethyl-phosphatidylethanolamine (DMPE), and phosphatidylcholine (PC) species in lipid extracts. The method employs a specific "mass-tag" strategy...... where DMPE, MMPE, and PE species are chemically methylated with deuterated methyliodide (CD(3)I) to produce PC molecules having class-specific mass offsets of 3, 6 and 9Da, respectively. The derivatized aminoglycerophospholipids release characteristic phosphorylcholine-like fragment ions having specific...... and DMPE, and abundant PE and PC species in a single mass spectrometric analysis. We demonstrated the efficacy of the methodology by conducting a series of biochemical experiments using stable isotope labeled ethanolamine to survey the activities and substrate specificities of enzymes involved in PE...

  16. Adsorption behavior of poly(dimethyl-diallylammonium chloride) on pulp fiber studied by cryo-time-of-flight secondary ion mass spectrometry and cryo-scanning electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Masumi, Takashi [Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho Chikusa-ku, Nagoya, Aichi 464-8601 (Japan); Matsushita, Yasuyuki, E-mail: ysmatsu@agr.nagoya-u.ac.jp [Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho Chikusa-ku, Nagoya, Aichi 464-8601 (Japan); Aoki, Dan [Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho Chikusa-ku, Nagoya, Aichi 464-8601 (Japan); Takama, Ruka [Technical Center, Nagoya University, Furo-cho Chikusa-ku Nagoya, Aichi 464-8601 (Japan); Saito, Kaori [Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho Chikusa-ku, Nagoya, Aichi 464-8601 (Japan); Kuroda, Katsushi [Department of Wood Properties, Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba, Ibaraki 305-8687 (Japan); Fukushima, Kazuhiko [Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho Chikusa-ku, Nagoya, Aichi 464-8601 (Japan)

    2014-01-15

    In this study, the adsorption behavior of poly(dimethyl-diallylammonium chloride) (PDADMAC), a retention agent used in papermaking, in a dual polymer system with anionic poly(acrylamide) (A-PAM) was investigated by time-of-flight secondary ion mass spectrometry (TOF-SIMS). Initially, fragment structures and cleavage patterns were identified via TOF-SIMS experiments with deuterium-labeled PDADMAC and the unlabeled analogue. Visualization of PDADMAC on a dry handsheet surface using traditional TOF-SIMS analysis indicated that the electrostatic interaction between coagulated PDADMAC and A-PAM was relatively weak. A novel cryo-TOF-SIMS/SEM system enabled the evaluation of a wet handsheet containing PDADMAC. Analysis of this sample indicated that PDADMAC adsorbs onto the fiber surface and collects preferentially on the tangled fibrils located between fibers.

  17. A pH and solvent optimized reverse-phase ion-paring-LC–MS/MS method that leverages multiple scan-types for targeted absolute quantification of intracellular metabolites

    DEFF Research Database (Denmark)

    McCloskey, Douglas; Gangoiti, Jon A.; Palsson, Bernhard O.;

    2015-01-01

    to the understanding of intracellular metabolism. Liquid chromatography coupled to mass spectrometry (LC–MS and LC–MS/MS) has become a reliable means with which to quantify a multitude of intracellular metabolites in parallel with great specificity and accuracy. This work details a method that builds and extends upon...... existing reverse phase ion-paring liquid chromatography methods for separation and detection of polar and anionic compounds that comprise key nodes of intracellular metabolism by optimizing pH and solvent composition. In addition, the presented method utilizes multiple scan types provided by hybrid...... instrumentation to improve confidence in compound identification. The developed method was validated for a broad coverage of polar and anionic metabolites of intracellular metabolism...

  18. Adaptive sliding mode back-stepping pitch angle control of a variable-displacement pump controlled pitch system for wind turbines.

    Science.gov (United States)

    Yin, Xiu-xing; Lin, Yong-gang; Li, Wei; Liu, Hong-wei; Gu, Ya-jing

    2015-09-01

    A variable-displacement pump controlled pitch system is proposed to mitigate generator power and flap-wise load fluctuations for wind turbines. The pitch system mainly consists of a variable-displacement hydraulic pump, a fixed-displacement hydraulic motor and a gear set. The hydraulic motor can be accurately regulated by controlling the pump displacement and fluid flows to change the pitch angle through the gear set. The detailed mathematical representation and dynamic characteristics of the proposed pitch system are thoroughly analyzed. An adaptive sliding mode pump displacement controller and a back-stepping stroke piston controller are designed for the proposed pitch system such that the resulting pitch angle tracks its desired value regardless of external disturbances and uncertainties. The effectiveness and control efficiency of the proposed pitch system and controllers have been verified by using realistic dataset of a 750 kW research wind turbine.

  19. Adaptive sliding mode back-stepping pitch angle control of a variable-displacement pump controlled pitch system for wind turbines.

    Science.gov (United States)

    Yin, Xiu-xing; Lin, Yong-gang; Li, Wei; Liu, Hong-wei; Gu, Ya-jing

    2015-09-01

    A variable-displacement pump controlled pitch system is proposed to mitigate generator power and flap-wise load fluctuations for wind turbines. The pitch system mainly consists of a variable-displacement hydraulic pump, a fixed-displacement hydraulic motor and a gear set. The hydraulic motor can be accurately regulated by controlling the pump displacement and fluid flows to change the pitch angle through the gear set. The detailed mathematical representation and dynamic characteristics of the proposed pitch system are thoroughly analyzed. An adaptive sliding mode pump displacement controller and a back-stepping stroke piston controller are designed for the proposed pitch system such that the resulting pitch angle tracks its desired value regardless of external disturbances and uncertainties. The effectiveness and control efficiency of the proposed pitch system and controllers have been verified by using realistic dataset of a 750 kW research wind turbine. PMID:26303957

  20. Helix Scan: A Scan Design for Diagnosis

    Institute of Scientific and Technical Information of China (English)

    WANG Fei; HU Yu; LI Xiaowei

    2007-01-01

    Scan design is a widely used design-for-testability technique to improve test quality and efficiency. For the scan-designed circuit, test and diagnosis of the scan chain and the circuit is an important process for silicon debug and yield learning. However, conventional scan designs and diagnosis methods abort the subsequent diagnosis process after diagnosing the scan chain if the scan chain is faulty. In this work, we propose a design-for-diagnosis scan strategy called helix scan and a diagnosis algorithm to address this issue. Unlike previous proposed methods, helix scan has the capability to carry on the diagnosis process without losing information when the scan chain is faulty. What is more, it simplifies scan chain diagnosis and achieves high diagnostic resolution as well as accuracy. Experimental results demonstrate the effectiveness of our design.

  1. Research on quality testing for active spot scanning proton and heavy ion accelerator%主动式点扫描质子重离子加速器质量检测研究

    Institute of Scientific and Technical Information of China (English)

    程金生; 袁继龙; 李明生

    2016-01-01

    Objective To study the quality testing of dose delivery system of the active spot scanning proton and heavy ion accelerator,in order to provide the reference for the quality control of related equipment.Methods In the four therapy rooms,both 0.6 cc chambers and Gafchromic EBT3 films were used,respectively,to test the accelerator for dose reproducibility,dose linearity,dose stability,depth dose distribution,beam scanning position deviation and radiation field uniformity in each therapy room.Results Dose reproducibility variation coefficients are all less than 1.5%,dose linearity's maximum deviations less than 2%,dose stability's deviations less than 2%,depth dose distribution stability within 2%,beam scanning position deviation less than 1 mm,consistency of irradiation field's deviation less than 2 mm,and flatness within ± 5%.Conclusions The indicators about quality testing for the active spot scanning proton and heavy ion accelerator are all in line with the requirements of IEC standards draft.%目的 对主动式点扫描质子重离子加速器剂量传输系统进行质量检测,为相关设备质量检测研究提供参考.方法 在4个治疗室中,分别采用0.6 CC指型电离室和辐射胶片测量质子重离子加速器在每间治疗室的输出剂量重复性、剂量线性、剂量日稳定性、深度剂量分布、束流扫描位置偏差和射野的一致性.结果 4个治疗室分别对应的4个终端的剂量重复性变异系数均<1.5%,剂量线性最大偏差均<2%,剂量日稳定性偏差均<2%,深度剂量分布稳定性均在2%之内,束流扫描位置偏差均<1 mm,射野一致性中射野大小偏差均<2 mm,射野平坦度均<±5%.结论 本研究涉及的主动式点扫描质子重离子加速器质量检测的各项指标均符合国际电工委员会(IEC)相关标准草案的要求.

  2. Design of Flight Control System Based on Backstepping Theory%基于Backstepping的飞行控制系统设计

    Institute of Scientific and Technical Information of China (English)

    董龙德; 陈澜

    2012-01-01

    现代无人机多采用多操纵面设计,这样使其性能有很大的提高,但是同时也导致了飞机控制系统设计复杂度的增加.尤其在其大迎角飞行时,是一个非线性、时变、耦合的多输入多输出( MIMO)系统,这更增加了控制系统设计的复杂度.文中针对这个问题,提出了一种基于Backstepping(回推控制)的控制律设计方法,克服了传统增益调参法需要纵横向解耦、参数切换等缺点,且具有调节时间短、超调量小、鲁棒性强和易于工程实现等优点.将无人机迎角、侧滑角和滚转角速度作为被控指标设计控制律.通过对某型无人战斗机进行飞行控制律的设计分析,得到了满意的控制效果.%Multi-control surfaces design is used in modem UAV. This improves UAV's performance a lot,but leads to increase the complexity of the aircraft control system design. Especially in the high attack angle of Qight.it is a nonlinear, time-varying,coupling and multiple-input multiple-output system. To address this issue,present a control design based od Backstepping. This method don't need decoupling on the vertical and horizontal,parameter switching and so on. And it has a short settling tune,small overshoot and strong robustness and easy engineering implementation, etc. The attack angle velocity, sideslip angle velocity and roll angular velocity of the UAV is used as control targets to design control law. By the control law design and analysis of a certain type of unmanned aircraft flight,get satisfactory control effect.

  3. Electron transfer with self-assembled copper ions at Au-deposited biomimetic films: mechanistic ‘anomalies’ disclosed by temperature- and pressure-assisted fast-scan voltammetry

    International Nuclear Information System (INIS)

    It has been suggested that electron transfer (ET) processes occurring in complex environments capable of glass transitions, specifically in biomolecules, under certain conditions may experience the medium’s nonlinear response and nonergodic kinetic patterns. The interiors of self-assembled organic films (SAMs) deposited on solid conducting platforms (electrodes) are known to undergo glassy dynamics as well, hence they may also exhibit the abovementioned ‘irregularities’. We took advantage of Cu2+ ions as redox-active probes trapped in the Au-deposited  −COOH-terminated SAMs, either L-cysteine, or 3-mercaptopropionic acid diluted by the inert 2-mercaptoethanol, to systematically study the impact of glassy dynamics on ET using the fast-scan voltammetry technique and its temperature and high-pressure extensions. We found that respective kinetic data can be rationalized within the extended Marcus theory, taking into account the frictionally controlled (adiabatic) mechanism for short-range ET, and complications due to the medium’s nonlinear response and broken ergodicity. This combination shows up in essential deviations from the conventional energy gap (overpotential) dependence and in essentially nonlinear temperature (Arrhenius) and high-pressure patterns, respectively. Biomimetic aspects for these systems are also discussed in the context of recently published results for interfacial ET involving self-assembled blue copper protein (azurin) placed in contact with a glassy environment. (paper)

  4. Linking environmental processes to the in situ functioning of microorganisms by high-resolution secondary ion mass spectrometry (NanoSIMS) and scanning transmission X-ray microscopy (STXM).

    Science.gov (United States)

    Behrens, Sebastian; Kappler, Andreas; Obst, Martin

    2012-11-01

    Environmental microbiology research increasingly focuses on the single microbial cell as the defining entity that drives environmental processes. The interactions of individual microbial cells with each other, the environment and with higher organisms shape microbial communities and control the functioning of whole ecosystems. A single-cell view of microorganisms in their natural environment requires analytical tools that measure both cell function and chemical speciation at the submicrometre scale. Here we review the technical capabilities and limitations of high-resolution secondary ion mass spectrometry (NanoSIMS) and scanning transmission (soft) X-ray microscopy (STXM) and give examples of their applications. Whereas NanoSIMS can be combined with isotope-labelling, thereby localizing the distribution of cellular activities (e.g. carbon/nitrogen fixation/turnover), STXM provides information on the location and chemical speciation of metabolites and products of redox reactions. We propose the combined use of both techniques and discuss the technical challenges of their joint application. Both techniques have the potential to enhance our understanding of cellular mechanisms and activities that contribute to microbially mediated processes, such as the biogeochemical cycling of elements, the transformation of contaminants and the precipitation of mineral phases.

  5. Understanding the micro structure of Berea Sandstone by the simultaneous use of micro-computed tomography (micro-CT) and focused ion beam-scanning electron microscopy (FIB-SEM).

    Science.gov (United States)

    Bera, Bijoyendra; Mitra, Sushanta K; Vick, Douglas

    2011-07-01

    Berea sandstone is the building block for reservoirs containing precious hydrocarbon fuel. In this study, we comprehensively reveal the microstructure of Berea sandstone, which is often treated as a porous material with interconnected micro-pores of 2-5 μm. This has been possible due to the combined application of micro-computed tomography (CT) and focused ion beam (FIB)-scanning electron microscopy (SEM) on a Berea sample. While the use of micro-CT images are common for geological materials, the clubbing and comparison of tomography on Berea with state-of-the-art microstructure imaging techniques like FIB-SEM reveals some unforeseen features of Berea microstructure. In particular, for the first time FIB-SEM has been used to understand the micro-structure of reservoir rock material like Berea sandstone. By using these characterization tools, we are able to show that the micro-pores (less than 30 μm) are absent below the solid material matrix, and that it has small interconnected pores (30-40 μm) and large crater-like voids (100-250 μm) throughout the bulk material. Three-dimensional pore space reconstructions have been prepared from the CT images. Accordingly, characterization of Berea sandstone specimen is performed by calculation of pore-structure volumes and determination of porosity values.

  6. Heart PET scan

    Science.gov (United States)

    ... nuclear medicine scan; Heart positron emission tomography; Myocardial PET scan ... A PET scan requires a small amount of radioactive material (tracer). This tracer is given through a vein (IV), ...

  7. Coronary Calcium Scan

    Science.gov (United States)

    ... the NHLBI on Twitter. What Is a Coronary Calcium Scan? A coronary calcium scan is a test ... you have calcifications in your coronary arteries. Coronary Calcium Scan Figure A shows the position of the ...

  8. Scanning ion-selective electrode technique and X-ray microanalysis provide direct evidence of contrasting Na+ transport ability from root to shoot in salt-sensitive cucumber and salt-tolerant pumpkin under NaCl stress.

    Science.gov (United States)

    Lei, Bo; Huang, Yuan; Sun, Jingyu; Xie, Junjun; Niu, Mengliang; Liu, Zhixiong; Fan, Molin; Bie, Zhilong

    2014-12-01

    Grafting onto salt-tolerant pumpkin rootstock can increase cucumber salt tolerance. Previous studies have suggested that this can be attributed to pumpkin roots with higher capacity to limit the transport of Na(+) to the shoot than cucumber roots. However, the mechanism remains unclear. This study investigated the transport of Na(+) in salt-tolerant pumpkin and salt-sensitive cucumber plants under high (200 mM) or moderate (90 mM) NaCl stress. Scanning ion-selective electrode technique showed that pumpkin roots exhibited a higher capacity to extrude Na(+), and a correspondingly increased H(+) influx under 200 or 90 mM NaCl stress. The 200 mM NaCl induced Na(+)/H(+) exchange in the root was inhibited by amiloride (a Na(+)/H(+) antiporter inhibitor) or vanadate [a plasma membrane (PM) H(+) -ATPase inhibitor], indicating that Na(+) exclusion in salt stressed pumpkin and cucumber roots was the result of an active Na(+)/H(+) antiporter across the PM, and the Na(+)/H(+) antiporter system in salt stressed pumpkin roots was sufficient to exclude Na(+) X-ray microanalysis showed higher Na(+) in the cortex, but lower Na(+) in the stele of pumpkin roots than that in cucumber roots under 90 mM NaCl stress, suggesting that the highly vacuolated root cortical cells of pumpkin roots could sequester more Na(+), limit the radial transport of Na(+) to the stele and thus restrict the transport of Na(+) to the shoot. These results provide direct evidence for pumpkin roots with higher capacity to limit the transport of Na(+) to the shoot than cucumber roots. PMID:24813633

  9. Scan BIST with biased scan test signals

    Institute of Scientific and Technical Information of China (English)

    XIANG Dong; CHEN MingJing; SUN JiaGuang

    2008-01-01

    The conventional test-per-scan built-in self-test (BIST) scheme needs a number of shift cycles followed by one capture cycle.Fault effects received by the scan flip-flops are shifted out while shifting in the next test vector like scan testing.Unlike deterministic testing,it is unnecessary to apply a complete test vector to the scan chains.A new scan-based BIST scheme is proposed by properly controlling the test signals of the scan chains,Different biased random values are assigned to the test signals of scan flip-flops in separate scan chains.Capture cycles can be inserted at any clock cycle if necessary.A new testability estimation procedure according to the proposed testing scheme is presented.A greedy procedure is proposed to select a weight for each scan chain.Experimental results show that the proposed method can improve test effectiveness of scan-based BIST greatly,and most circuits can obtain complete fault coverage or very close to complete fault coverage.

  10. 数控机床直线伺服系统智能反推控制的研究%Study on Intelligent Backstepping for Linear Servo System of NC Machine Tool

    Institute of Scientific and Technical Information of China (English)

    关丽荣

    2012-01-01

    针对高速高精数控机床直线伺服系统,考虑参数变化、外部负载扰动和摩擦力等不确定因素对系统伺服性能的影响,设计基于递归模糊神经网络( RFNN)的反推控制器,利用了递归神经网络具有捕获系统动态信息的优点,可实时补偿不确定因素对跟踪性能的影响.仿真结果表明,该控制策略明显降低了不确定因素对系统性能的影响,从而显著提高了直线伺服系统的位置跟踪精度.%In view of high speed and precise NC machine tool droved by linear servo systems, an adaptive backstepping sliding mode controller (ABSMC) was proposed considering the influence of the lumped uncertainties with parameter variations, external force disturbances and frictions for linear servo systems. , an intelligence backstepping control is introduced to suppress further the tracking error. Considering the influence of the lumped uncertainties with parameter variations, external force disturbances and frictions for PMLSM, a backstepping controller based on recurrent neural network is designed. The advantages of recurrent neural network with capturing the dynamic information of system are used, can compensate real time the influence of tracking performance. Simulation results show that the proposed algorithm can reduce effectively the influence of the lumped uncertainties on system performances. The tracking performances of the PMLSM servo system are significantly improved.

  11. 船舶航向非线性Backstepping自适应鲁棒控制%Ship Course Nonlinear Adaptive Backstepping Control

    Institute of Scientific and Technical Information of China (English)

    叶宝玉; 王钦若; 熊建斌; 邓九英

    2013-01-01

    针对非线性船舶航向控制中船舶参数及扰动的不确定性,提出了带有积分器的非线性Backstepping自适应鲁棒控制算法.首先对扰动界已知的非线性船舶实现船舶航向跟踪控制,并取得了全局指数稳定的控制效果.考虑到海洋环境的随机性对船舶的影响,又对扰动界未知的非线性船舶实现船舶航向跟踪控制,并利用Lyapunov稳定性理论证明其满足L2控制标准,取得了全局稳定的控制效果.仿真结果验证了所设计方法的有效性.%Considering the nonlinear ship course control with uncertain parameters and disturbance,a nonlinear adaptive Backstepping control algorithm with integrator is proposed.Firstly,the control algorithm realizes the tracking control of nonlinear ship course with the known perturbation bounds,and obtained the control effects of global exponential stability.Taking the influence of the random Marine environment to the ship into account,the other control algorithm realizes the tracking control of nonlinear ship course with the unknown perturbation bounds,and proved that the control algorithm meets L2 control standards and has the control effect of global stability make use of Lyapunov stability theory.The simulation results show the effectiveness of the design method.

  12. Conventional cerebrospinal fluid scanning

    Energy Technology Data Exchange (ETDEWEB)

    Schicha, H.

    1985-06-01

    Conventional cerebrospinal fluid scanning (CSF scanning) today is mainly carried out in addition to computerized tomography to obtain information about liquor flow kinetics. Especially in patients with communicating obstructive hydrocephalus, CSF scanning is clinically useful for the decision for shunt surgery. In patients with intracranial cysts, CSF scanning can provide information about liquor circulation. Further indications for CSF scanning include the assessment of shunt patency especially in children, as well as the detection and localization of cerebrospinal fluid leaks.

  13. Evaluation of Pore Networks in Caprocks at Geologic Storage Sites: A Combined Study using High Temperature and Pressure Reaction Experiments, Small Angle Neutron Scattering, and Focused Ion Beam-Scanning Electron Microscopy

    Science.gov (United States)

    Mouzakis, K. M.; Sitchler, A.; Wang, X.; McCray, J. E.; Kaszuba, J. P.; Rother, G.; Dewers, T. A.; Heath, J. E.

    2011-12-01

    Low permeability rock units, often shales or mudstones, that overlie geologic formations under consideration for CO2 sequestration will help contain injected CO2. CO2 that does flow through these rocks will dissolve into the porewaters, creating carbonic acid lowering the pH. This perturbation of the system may result in mineral dissolution or precipitation, which can change the pore structure and impact the flow properties of the caprocks. In order to investigate the impacts that reaction can have on caprock pore structure, we performed a combination of high pressure high temperature reaction experiments, small angle neutron scattering (SANS) experiments and high resolution focused ion beam-scanning electron microscope (FIB-SEM) imaging on samples from the Gothic shale and Marine Tuscaloosa Group. Small angle neutron scattering was performed on unreacted and reacted caprocks at the High Flux Isotope Reactor at Oak Ridge National Laboratory. New precipitates and pores are observed in high-resolution images of the reacted samples. The precipitates have been preliminarily identified as gypsum or anhydrite, and sulfide minerals. Results from small angle neutron scattering, a technique that provides information about pores and pore/mineral interfaces at scales ~ 5 to 300 nm, show an increased porosity and specific surface area after reaction with brine and CO2. However, there appear to be differences in how the pore networks change between the two samples that are related to sample mineralogy and original pore network structure. Changes to pores and formation of new pores may lead to different capillary sealing behavior and permeability. This combination of controlled laboratory experiments, neutron scattering and high-resolution imaging provides detailed information about the geochemical processes that occur at the pore scale as CO2 reacts with rocks underground. Such information is integral to the evaluation of large-scale CO2 sequestration as a feasible technology

  14. Three dimensional analysis of the pore space in fine-grained Boom Clay, using BIB-SEM (broad-ion beam scanning electron microscopy), combined with FIB (focused ion-beam) serial cross-sectioning, pore network modeling and Wood's metal injection

    Science.gov (United States)

    Hemes, Susanne; Klaver, Jop; Desbois, Guillaume; Urai, Janos

    2014-05-01

    The Boom Clay is, besides the Ypresian clays, one of the potential host rock materials for radioactive waste disposal in Belgium (Gens et al., 2003; Van Marcke & Laenen, 2005; Verhoef et al., 2011). To access parameters, which are relevant for the diffusion controlled transport of radionuclides in the material, such as porosity, pore connectivity and permeability, it is crucial to characterize the pore space at high resolution (nm-scale) and in 3D. Focused-ion-beam (FIB) serial cross-sectioning in combination with high resolution scanning electron microscopy (SEM), pore network modeling, Wood's metal injection and broad-ion-beam (BIB) milling, constitute a superior set of methods to characterize the 3D pore space in fine-grained, clayey materials, down to the nm-scale resolution. In the present study, we identified characteristic 3D pore space morphologies, determined the 3D volume porosity of the material and applied pore network extraction modeling (Dong and Blunt, 2009), to access the connectivity of the pore space and to discriminate between pore bodies and pore throats. Moreover, we used Wood's metal injection (WMI) in combination with BIB-SEM imaging to assess the pore connectivity at a larger scale and even higher resolution. The FIB-SEM results show a highly (~ 90 %) interconnected pore space in Boom Clay, down to the resolution of ~ 3E+03 nm³ (voxel-size), with a total volume porosity of ~ 20 %. Pore morphologies of large (> 5E+08 nm³), highly interconnected pores are complex, with high surface area to volume ratios (shape factors G ~ 0.01), whereas small (areas (REAs) (Hemes et al., 2013).

  15. Sample preparation method for scanning force microscopy

    CERN Document Server

    Jankov, I R; Szente, R N; Carreno, M N P; Swart, J W; Landers, R

    2001-01-01

    We present a method of sample preparation for studies of ion implantation on metal surfaces. The method, employing a mechanical mask, is specially adapted for samples analysed by Scanning Force Microscopy. It was successfully tested on polycrystalline copper substrates implanted with phosphorus ions at an acceleration voltage of 39 keV. The changes of the electrical properties of the surface were measured by Kelvin Probe Force Microscopy and the surface composition was analysed by Auger Electron Spectroscopy.

  16. Rapid Frequency Scan EPR

    OpenAIRE

    Tseitlin, Mark; Rinard, George A.; Quine, Richard W.; Eaton, Sandra S.; Eaton, Gareth R.

    2011-01-01

    In rapid frequency scan EPR with triangular scans, sufficient time must be allowed to insure that the magnetization in the x,y plane decays to baseline at the end of the scan, which typically is about 5 T2 after the spins are excited. To permit relaxation of signals excited toward the extremes of the scan the total scan time required may be much longer than 5 T2. However, with periodic, saw-tooth excitation, the slow-scan EPR spectrum can be recovered by Fourier deconvolution of data recorded...

  17. 基于反步滑模控制的TCP网络的主动队列管理%Active queue management for TCP networks based on backstepping sliding mode control

    Institute of Scientific and Technical Information of China (English)

    叶成荫

    2012-01-01

    For the problem of congestion control in TCP networks,considered the parameter uncertainties of the networks itself and the disturbance of unresponsive flows, an active queue management algorithm is proposed based on the backstepping sliding mode control. Considered the bound of the lumped uncertainty known and not to be small, a backstepping sliding mode controller is designed to compensate the effects of the system uncertainties. The simulation results verify that the proposed algorithm has good robustness and fast system response for complicated changes in TCP networks.%针对TCP网络的拥塞问题,考虑到网络本身存在参数不确定因素和非响应流的干扰,基于反步滑模控制提出了一种主动队列管理算法.在总的不确定的界已知而且不必很小的情况下,设计了一种反步滑模控制器来补偿系统不确定所带来的影响.仿真结果表明,该方法对TCP网络的复杂变化具有较好的鲁棒性和较快的系统响应.

  18. RBC nuclear scan

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003835.htm RBC nuclear scan To use the sharing features on this page, please enable JavaScript. An RBC nuclear scan uses small amounts of radioactive material to ...

  19. Pulmonary ventilation/perfusion scan

    Science.gov (United States)

    V/Q scan; Ventilation/perfusion scan; Lung ventilation/perfusion scan ... A pulmonary ventilation/perfusion scan is actually two tests. They may be done separately or together. During the perfusion scan, a health care ...

  20. Pulmonary ventilation/perfusion scan

    Science.gov (United States)

    V/Q scan; Ventilation/perfusion scan; Lung ventilation/perfusion scan ... A pulmonary ventilation/perfusion scan is actually two tests. They may be done separately or together. During the perfusion scan, a health ...

  1. Rapid frequency scan EPR.

    Science.gov (United States)

    Tseitlin, Mark; Rinard, George A; Quine, Richard W; Eaton, Sandra S; Eaton, Gareth R

    2011-08-01

    In rapid frequency scan EPR with triangular scans, sufficient time must be allowed to insure that the magnetization in the x, y plane decays to baseline at the end of the scan, which typically is about 5T(2) after the spins are excited. To permit relaxation of signals excited toward the extremes of the scan the total scan time required may be much longer than 5T(2). However, with periodic, saw-tooth excitation, the slow-scan EPR spectrum can be recovered by Fourier deconvolution of data recorded with a total scan period of 5T(2), even if some spins are excited later in the scan. This scan time is similar to polyphase excitation methods. The peak power required for either polyphase excitation or rapid frequency scans is substantially smaller than for pulsed EPR. The use of an arbitrary waveform generator (AWG) and cross loop resonator facilitated implementation of the rapid frequency scan experiments reported here. The use of constant continuous low B(1), periodic excitation waveform, and constant external magnetic field is similar to polyphase excitation, but could be implemented without the AWG that is required for polyphase excitation. PMID:21664848

  2. Line-scanning, stage scanning confocal microscope

    Science.gov (United States)

    Carucci, John A.; Stevenson, Mary; Gareau, Daniel

    2016-03-01

    We created a line-scanning, stage scanning confocal microscope as part of a new procedure: video assisted micrographic surgery (VAMS). The need for rapid pathological assessment of the tissue on the surface of skin excisions very large since there are 3.5 million new skin cancers diagnosed annually in the United States. The new design presented here is a confocal microscope without any scanning optics. Instead, a line is focused in space and the sample, which is flattened, is physically translated such that the line scans across its face in a direction perpendicular to the line its self. The line is 6mm long and the stage is capable of scanning 50 mm, hence the field of view is quite large. The theoretical diffraction-limited resolution is 0.7um lateral and 3.7um axial. However, in this preliminary report, we present initial results that are a factor of 5-7 poorer in resolution. The results are encouraging because they demonstrate that the linear array detector measures sufficient signal from fluorescently labeled tissue and also demonstrate the large field of view achievable with VAMS.

  3. Comparative evaluation of scanned stripping techniques: SSCP vs. SSV

    NARCIS (Netherlands)

    Town, R.M.; Leeuwen, van H.P.

    2006-01-01

    The characteristic features of scanned deposition potential curves constructed from stripping chronopotentiometry (SSCP) and various modes of stripping voltammetry (SSV) are critically evaluated. The strengths and weaknesses of each method for identification of metal ion speciation features and susc

  4. Radionucleotide scanning in osteomyelitis

    International Nuclear Information System (INIS)

    Radionucleotide bone scanning can be an excellent adjunct to the standard radiograph and clinical findings in the diagnosis of osteomyelitis. Bone scans have the ability to detect osteomyelitis far in advance of the standard radiograph. The sequential use of technetium and gallium has been useful in differentiating cellulitis and osteomyelitis. Serial scanning with technetium and gallium may be used to monitor the response of osteomyelitis to antibiotic therapy

  5. Getting a CAT Scan

    Medline Plus

    Full Text Available ... Crushes What's a Booger? Getting a CAT Scan (Video) KidsHealth > For Kids > Getting a CAT Scan (Video) Print A A A Text Size en español Obtención de una tomografía computada (video) CAT stands for "computerized axial tomography." Translated, that ...

  6. Getting a CAT Scan

    Medline Plus

    Full Text Available ... Here's Help White House Lunch Recipes Getting a CAT Scan (Video) KidsHealth > For Kids > Getting a CAT Scan (Video) Print A A A Text Size en español Obtención de una tomografía computada (video) CAT stands for "computerized axial tomography." Translated, that means ...

  7. Frequency scanning microstrip antennas

    DEFF Research Database (Denmark)

    Danielsen, Magnus; Jørgensen, Rolf

    1979-01-01

    The principles of using radiating microstrip resonators as elements in a frequency scanning antenna array are described. The resonators are cascade-coupled. This gives a scan of the main lobe due to the phase-shift in the resonator in addition to that created by the transmission line phase...

  8. Abdominal CT scan

    Science.gov (United States)

    ... than regular x-rays. Many x-rays or CT scans over time may increase your risk for cancer. However, the risk from any one scan is small. Talk to your doctor about this risk and the benefit of the test for getting a correct diagnosis ...

  9. Environmental Scanning Report.

    Science.gov (United States)

    Truckee Meadows Community Coll., Sparks, NV.

    This report describes Truckee Meadows Community College's (Nevada) environmental scanning process and results. The college decided that environmental scanning and forecasting techniques should be used to plan for both short-term and long-term external factors that impact programs, enrollment, and budgets. Strategic goals include: (1) keeping pace…

  10. Optical Scanning Applications.

    Science.gov (United States)

    Wagner, Hans

    The successful use of optical scanning at the University of the Pacific (UOP) indicates that such techniques can simplify a number of administrative data processing tasks. Optical scanning is regularly used at UOP to assist with data processing in the areas of admissions, registration and grade reporting and also has applications for other tasks…

  11. Knee CT scan

    Science.gov (United States)

    Risks of CT scans include: Exposure to radiation Allergy to contrast dye CT scans give off more radiation than ... injected contrast dye. The most common type of contrast contains ... you have this an iodine allergy. If you need to have this kind of ...

  12. Getting a CAT Scan

    Medline Plus

    Full Text Available ... Dictionary of Medical Words En Español What Other Kids Are Reading Movie: Digestive System Winter Sports: Sledding, ... Booger? Getting a CAT Scan (Video) KidsHealth > For Kids > Getting a CAT Scan (Video) Print A A ...

  13. Getting a CAT Scan

    Medline Plus

    Full Text Available ... Skiing, Snowboarding, Skating Crushes What's a Booger? Getting a CAT Scan (Video) KidsHealth > For Kids > Getting a CAT Scan (Video) Print A A A Text Size en español Obtención de ...

  14. Getting a CAT Scan

    Medline Plus

    Full Text Available ... Snowboarding, Skating Crushes What's a Booger? Getting a CAT Scan (Video) KidsHealth > For Kids > Getting a CAT Scan (Video) Print A A A Text Size en español Obtención de una tomografía computada (video) CAT stands for "computerized axial tomography." Translated, that means ...

  15. Backstepping adaptive sliding mode control for unmanned surface vessel course tracking with water-jet-propelled%喷水推进型无人艇航向跟踪的反步自适应滑模控制

    Institute of Scientific and Technical Information of China (English)

    廖煜雷; 庞永杰; 庄佳园

    2012-01-01

    This paper presented a method of Backstepping adaptive sliding mode control for the course tracking nonlinear system of the unmanned hydroplane with single water-jet-propelled. The autopilot system consisted of the nonlinear ship response model and the rudder actuator dynamics. The motion response model took account of the modeling errors and external disturbances. It transformed the original system into a nonlinear system based on global diffeomorphism change of coordinate. And propsed an adaptive sliding mode control law based on sliding mode control theory and Backstepping method. By means of Lya-punov function, it proved that the proposed control law could render the course tracking system globally asymptotically stable. Simulations results illustrate the effectiveness of the proposed method.%针对单泵喷水推进型无人滑行艇的航向跟踪非线性系统,提出了一种反步自适应滑模控制方法.该系统由无人艇运动非线性响应模型和舵机伺服系统组成,并考虑运动响应模型的建模误差、外界干扰力等非匹配不确定性,利用全局微分同胚坐标变换将原系统变换为具有下三角特征的非线性系统.基于Backstepping方法和滑模控制理论,提出了一种自适应滑模控制律;利用Lyapunov函数,证明该控制律保证了航向跟踪系统的全局渐近稳定性.仿真对比结果验证了所提出控制器的有效性.

  16. 基于自适应反步滑模控制的主动队列管理%Active Queue Management Based on Adaptive Backstepping Sliding Mode Control

    Institute of Scientific and Technical Information of China (English)

    叶成荫

    2012-01-01

    针对TCP网络的拥塞控制问题,基于自适应反步滑模控制提出了一种主动队列管理算法.由于系统的不确定在实际工程中很难或根本无法事先获得,设计一个自适应律来实时适应系统不确定的值,从而消除系统不确定所带来的影响.利用此自适应律,提出一个自适应反步滑模控制器,使得系统具有较好的暂态性能和鲁棒性能.仿真结果表明,该方法对TCP网络的复杂变化具有较好的鲁棒性和较快的系统响应.%For the problem of congestion control in TCP networks,an active queue management algorithm is proposed based on the adaptive backstepping sliding mode control. Since the lumped uncertainties of the network systems is difficult to obtain in advance in practical applications, an adaptive law is proposed to compensate the effects of the system uncertainties. Using the proposed adaptive law, an adaptive backstepping sliding mode controller is proposed to make systems possesses the advantages of good transient control and robust performance. Simulation results verifies that the proposed algorithm has good robustness and fast system response for complicated changes in TCP networks.

  17. 飞翼布局无人机反步L2增益纵向着陆鲁棒控制%Backstepping L2 gain robust control of longitudinal landing of flying-wing UAV

    Institute of Scientific and Technical Information of China (English)

    谭健; 周洲; 祝小平; 许晓平

    2016-01-01

    For the longitudinal landing control problem of flying⁃wing UAV with unknown external disturbances, a backstepping L2 gain robust control scheme based on super twisting sliding mode disturbance observer and tracking differentiator is proposed. The tracking differentiator is introduced to calculate the derivative of virtual control law which is very difficult to evaluate with the traditional backstepping control. Super twisting sliding mode disturbance observer and L2 gain robust item are designed to increase the robustness of the control system. Simulation results show:the altitude and airspeed of UAV are tracked on control command, vertical ground speed is within the allowable range. Compared with traditional PID control scheme, the proposed control scheme has better automatical landing control performance.%针对存在干扰的飞翼布局无人机纵向着陆控制问题,提出一种基于super twisting滑模干扰观测器与跟踪微分器的反步L2增益鲁棒控制方案。为解决反步控制虚拟控制量求导复杂的问题,设计了跟踪微分器对虚拟控制量进行求导,同时综合采用super twisting滑模干扰观测器和L2增益鲁棒项增强了控制系统的鲁棒性。仿真结果表明,无人机高度、空速都跟踪上控制指令,垂直接地速度在允许的范围内,与传统的PID着陆控制方案相比具有更好的着陆控制性能。

  18. Robust backstepping control based on disturbance observer for hypersonic vehicle%基于干扰观测器的高超音速飞行器鲁棒反步控制

    Institute of Scientific and Technical Information of China (English)

    王首斌; 王新民; 谢蓉; 姚从潮

    2013-01-01

    To solve the control problem of a general hypersonic vehicle which is a strict-feedback nonlinear uncertain MIMO system, a robust backstepping control strategy based on the disturbance observer is proposed. The super-twisting algorithm is used to estimate and compensate for disturbances. The finite time convergence is guaranteed. A nonlinear backstepping control law is designed. Robust items are designed to make the whole control system has the L2 gain which is less than or equal to the prescribed positive const. Theoretical analysis is done to validate that the system can satisfy dissipative inequality and is uniformly ultimately bounded. The simulation results show that the developed method is effective and deals with the problem of uncertain factors preferably.%针对高超音速飞行器严格反馈不确定非线性MIMO系统,提出一种基于干扰观测器的鲁棒反步控制方法。该方法采用超扭曲算法设计干扰观测器以估计系统复合干扰,观测误差有限时间收敛。设计非线性反步控制律,引入鲁棒项使得系统满足干扰到性能输出的L2增益不超过设定的正实数,满足耗散不等式,使闭环系统跟踪误差一致最终有界稳定。仿真结果表明,所设计的控制律可以有效抑制系统复合干扰的影响,设计方法可行。

  19. Dynamic control of a cable-driven humanoid-shoulder joint based on backstepping technique%基于后推技术的绳驱动拟人肩关节动力学控制

    Institute of Scientific and Technical Information of China (English)

    游贤强; 陈伟海; 崔翔; 于守谦

    2012-01-01

    Aiming at the problems that cable-driven parallel manipulator is difficult to create model and control,the dynamic model of the humanoid-shoulder joint was built by using Lagrange dynamics method so as to obtain the standard form of dynamic equation.Taking into account the redundant actuation and single-direction force for the cable,tension distribution algorithm based on the minimum pre-tightening force was proposed to calculate driving force of each cable.Based on backstepping technique,the control law of the system model was designed for the robot trajectory tracking control problem.The results of simulation show backstepping-based control method is superior in convergence speed,and the driving force of each cable is more than the required minimum tension to keep the cable tensional.%针对并联式绳驱动机器人建模困难、控制复杂等问题,采用拉格朗日动力学建模方法,推导得到便于控制器设计的标准动力学方程,考虑绳驱动的冗余特性和绳索的单方向受力性,提出基于最小预紧力的张力分配算法,求解出各绳索的驱动力.针对机器人轨迹跟踪控制问题,设计了基于后推技术的系统模型控制律.仿真结果表明:后推技术法在收敛速度方面明显优于计算力矩法,且各绳索的驱动力皆能满足其张紧所需的最小张力.

  20. 基于反演滑模控制的导弹制导控制一体化设计%Integrated design of missile guidance and control based on back-stepping and sliding mode control

    Institute of Scientific and Technical Information of China (English)

    齐辉; 张泽; 韩鹏鑫; 许江涛; 张德伟

    2016-01-01

    Aiming at the defects that the traditional design for guidance and control is separated when inter-cepting high-speed maneuvering targets,an integrated algorithm for missile guidance and control based on back-stepping and sliding is presented.Firstly,the integrated mode of guidance and control is established based on the differential geometry theory.Then,according to the principle of parallel approach,an integrated algorithm of guidance and control is proposed by using the method of back-stepping and the sliding mode control (SMC) technique.Finally,system stability has been proved based on the Lyapunov theory.The simulation results demonstrate that the design for the integrated method of guidance and control can overcome the interference of unmodeled dynamics uncertainty and target maneuver,which has strong robustness.%针对传统制导和控制分开设计在拦截高速机动目标时的不足,给出了一种反演滑模一体化制导控制算法。首先利用微分几何理论,建立了一体化制导控制模型;然后根据平行接近原理,基于滑模控制和反演法,设计了一种反演滑模控制的导弹制导控制一体化算法;最后基于 Lyapunov 理论证明了系统的稳定性。数值仿真结果表明,所给出的一体化制导控制方法能够克服未建模的不确定性和目标机动干扰,具有较强的鲁棒性。

  1. 基于反步法的欠驱动UUV的3维路径跟踪控制%3D Path Following Control of Underactuated UUV Based on Backstepping

    Institute of Scientific and Technical Information of China (English)

    严浙平; 晏正新; 牟春晖; 边信黔

    2012-01-01

    Path following controller design of underactuated unmanned underwater vehicle (UUV) and its stability analysis in 3-dimensional space are studied. Firstly, a 6-DOF (degrees of freedom) kinematic model and a 6-DOF dynamic mode! Of the underactuated UUV in the form of second-order integrator are established. For the kinematic model, taking the position errors as the virtual control variable, a path following controller is designed based on backstepping. It is theoretically proved that the designed path following control system is stable according to the Lyapunov theory. The path following control of underactuaied UUV in 3-dimensional space is realized by the controller. The simulation results demonstrate its effectiveness.%研究了欠驱动无人水下航行器(unmanned underwater vehicle,UUV)在3维空间中的路径跟踪控制器设计及其稳定性分析问题.首先建立2阶积分器形式的欠驱动UUV空间6自由度运动模型和动力学模型.针对该运动模型,以位置误差作为虚拟控制变量,基于反步法(backstepping)设计路径跟踪控制器.根据李亚普诺夫理论,在理论上证明了所设计的路径跟踪控制系统是稳定的.该控制器实现了欠驱动UUV 3维空间的路径跟踪控制.仿真结果验证了控制器的有效性.

  2. 控制受限的BTT导弹反演自适应滑模控制研究%Adaptive backstepping sliding mode control for BTT missiles with control input constraints

    Institute of Scientific and Technical Information of China (English)

    朱凯; 齐乃明

    2011-01-01

    针对具有非匹配不确定性的倾斜转弯(bank-to-turn,BTT)导弹在控制受限情况下的鲁棒控制问题,提出了一种自适应滑模反演控制方法.反演设计的每一步中,采用自适应算法对不确定性的上界进行估计,给出了具有范数型切换函数的连续的自适应滑模控制律.在实际控制量的设计中显式地考虑了控制量的饱和特性,保证了系统在控制饱和时的稳定性,并采用Lyapunov稳定性理论证明了跟踪误差最终有界.仿真结果表明,在气动参数摄动和控制量存在饱和的情况下,本文的控制方法仍能快速,准确地跟踪指令信号,具有较强的鲁棒性.%Concerning with robust control of a bank-to-turn ( BTT) missile in the presence of unmatched uncertainties and control input saturation, an adaptive backstepping sliding mode controller is designed. The upper bound of uncertainties is adaptively estimated at each step of the backstepping design, and continuous sliding mode control with norm switching funcion is used. To ensure the stability under control input saturation, control saturation is explicitly accounted in the design of real control. Using the Lyapunov stability theorem,the tracking error is shown to be ultimately bounded Simulation results show the good dynamic characteristics and robustness of the proposed method in the presence of aerodynamic dispersion and control input saturation

  3. Scanning with Iodine-125

    International Nuclear Information System (INIS)

    The use of I125 as I125-iodide for scanning of the thyroid and of thyroid carcinoma métastasés and as I125-labelled Rose Bengal for scanning of the liver has been investigated in our laboratories. In some patients, the thyroid scans and the scans of thyroid carcinoma metastases were repeated with I131. The liver scans were repeated with colloidal Au198. Cold nodules in the thyroid which could not be detected with I131 were clearly seen with I125. Anterior métastasés in the lungs could be differentiated from posterior métastasés with I125, while with I131 this was not possible. Using the same doses of radioactivity the background with I131 was much higher and could not be eliminated, as this would have reduced the counting rate over the lesions to levels which could not be detected. Some of the photoscans and mechanical scans of livers carried out with colloidal Au198 could not be interpreted. However, ''cold'' lesions were clearly seen on the scans of the same livers with I125-labelled Rose Bengal. (author)

  4. Ion beam diagnosis

    International Nuclear Information System (INIS)

    This report is an introduction to ion beam diagnosis. After a short description of the most important ion beam parameters measurements of the beam current by means of Faraday cups, calorimetry, and beam current transformers and measurements of the beam profile by means of viewing screens, profile grids and scanning devices, and residual gas ionization monitors are described. Finally measurements in the transverse and longitudinal phase space are considered. (HSI)

  5. The conical scan radiometer

    Science.gov (United States)

    Prosch, T.; Hennings, D.

    1982-07-01

    A satellite-borne conical scan radiometer (CSR) is proposed, offering multiangular and multispectral measurements of Earth radiation fields, including the total radiances, which are not available from conventional radiometers. Advantages of the CSR for meteorological studies are discussed. In comparison to conventional cross track scanning instruments, the CSR is unique with respect to the selected picture element size which is kept constant by means of a specially shaped detector matrix at all scan angles. The conical scan mode offers the chance to improve angular sampling. Angular sampling gaps of previous satellite-borne radiometers can be interpolated and complemented by CSR data. Radiances are measured through 10 radiometric channels which are selected to study cloudiness, water vapor, ozone, surface albedo, ground and mean stratospheric temperature, and aerosols.

  6. Pediatric CT Scans

    Science.gov (United States)

    The Radiation Epidemiology Branch and collaborators have initiated a retrospective cohort study to evaluate the relationship between radiation exposure from CT scans conducted during childhood and adolescence and the subsequent development of cancer.

  7. Pelvic CT scan

    Science.gov (United States)

    ... Abscess (collection of pus) Bladder stones Broken bone Cancer Diverticulitis ... scans over time may increase your risk of cancer. But the risk from any ... to contrast dye. Let your provider know if you have ever ...

  8. Sinus CT scan

    Science.gov (United States)

    ... may be due to: Birth defects Bone fractures Cancer Polyps in the sinuses Sinus infection (sinusitis) ... scans over time may increase your risk for cancer. However, the risk ... to contrast dye. Let your provider know if you have ever ...

  9. Scanning ultrafast electron microscopy

    OpenAIRE

    Yang, Ding-Shyue; Mohammed, Omar F.; Zewail, Ahmed H.

    2010-01-01

    Progress has been made in the development of four-dimensional ultrafast electron microscopy, which enables space-time imaging of structural dynamics in the condensed phase. In ultrafast electron microscopy, the electrons are accelerated, typically to 200 keV, and the microscope operates in the transmission mode. Here, we report the development of scanning ultrafast electron microscopy using a field-emission-source configuration. Scanning of pulses is made in the single-electron mode, for whic...

  10. Uniform irradiation system using beam scanning method for cyclotron

    International Nuclear Information System (INIS)

    JAERI AVF-cyclotron is equipped with an ion beam scanner for large area irradiation. The two-dimensional fluence distribution of ion beam obtained using cellulose triacetate film dosimeter was not uniform. This is resulted from the distortion of excitation current for electromagnet of the scanner. So, the beam scanning condition, i.e., the relation between the ion species, the beam profile and the scanning width, was extremely limited to make a good uniformity. We have developed a beam scanning simulator to get fluence distributions by calculation and then compared the simulated distributions with the measured ones. It was revealed that the both of them are in good agreement and the beam scanning condition to get good uniformity was led by using this simulator. On the basis of these results, the power supply of scanner was improved. A good uniformity of beam distribution was available. (author)

  11. Advanced Network Scanning

    Directory of Open Access Journals (Sweden)

    Ashiqur Rahman

    2016-07-01

    Full Text Available Network scanning is à procedure for identifying active hosts on a network, either for the purpose of attacking them or for network security assessment. Scanning procedures, such as ping sweeps and port scans, return information about which IP addresses map to live hosts that are active on the Internet and what services they offer. Another scanning method, inverse mapping, returns information about what IP addresses do not map to live hosts; this enables an attacker to make assumptions about viable addresses. Scanning is one of three components of intelligence gathering for an attacker. In the foot printing phase, the attacker creates a profile of the target organization, with information such as its domain name system (DNS and e-mail servers, and its IP address range. Most of this information is available online. In the scanning phase, the attacker finds information about the specific IP addresses that can be accessed over the Internet, their operating systems, the system architecture, and the services running on each computer. In the enumeration phase, the attacker gathers information such as network user and group names, routing tables, and Simple Network Management Protocol (SNMP data

  12. Lung Ventilation/Perfusion Scan

    Science.gov (United States)

    ... two types of scans: ventilation and perfusion. The ventilation scan shows where air flows in your lungs. The perfusion scan shows where blood flows in your lungs. Both scans use radioisotopes (a low-risk radioactive substance). For the ventilation scan, you ...

  13. Scanning Probe Microscopy and Spectroscopy

    Science.gov (United States)

    Wiesendanger, Roland

    1994-09-01

    Preface; List of acronyms; Introduction; Part I. Experimental Methods and Theoretical Background of Scanning Probe Microscopy and Spectroscopy: 1. Scanning tunnelling microscopy; 2. Scanning force microscopy; 3. Related scanning probe techniques; Part II. Applications of Scanning Probe Microscopy and Spectroscopy: 4. Condensed matter physics; 5. Chemistry; 6. Organic materials; 7. Metrology and standards; 8. Nanotechnology; References; Index.

  14. Lung scans and malignancy

    International Nuclear Information System (INIS)

    An experience of pulmonary isotope scanning carried out with mercury 197 labelled mercury chloride and acetate, cobalt 57-labelled bleomycin, and Cu67 and Cu64 labelled copper citrate was presented. The scans were carried out with various isotopes supplied by the French Atomic Energy Authority, and gave comparable results, which may be summarised as follows: increased uptake in more than 90% of cases of carcinoma, absent uptake in all cases of benign tumour, frequent increased uptake in acute or advanced inflammatory lesions, absence of uptake, very commonly, in tuberculoma and chronic lesions with scar formation. Radio-isotope scan using Cu67 labelled copper citrate permitted discrimination of malignant tumours (increased fixation which showed up best at the 24th hour) from inflammatory lesions (increased fixation which was reduced on the 24th hour). The positive or negative character of the fixation in a given lesions remains the same, whatever the isotope used in our experience

  15. Adaptive Optical Scanning Holography

    Science.gov (United States)

    Tsang, P. W. M.; Poon, Ting-Chung; Liu, J.-P.

    2016-01-01

    Optical Scanning Holography (OSH) is a powerful technique that employs a single-pixel sensor and a row-by-row scanning mechanism to capture the hologram of a wide-view, three-dimensional object. However, the time required to acquire a hologram with OSH is rather lengthy. In this paper, we propose an enhanced framework, which is referred to as Adaptive OSH (AOSH), to shorten the holographic recording process. We have demonstrated that the AOSH method is capable of decreasing the acquisition time by up to an order of magnitude, while preserving the content of the hologram favorably. PMID:26916866

  16. State-reconstruction-based robust backstepping control of air-breathing hypersonic vehicles%基于状态重构的吸气式高超声速飞行器鲁棒反演控制

    Institute of Scientific and Technical Information of China (English)

    卜祥伟; 吴晓燕; 马震; 张蕊

    2015-01-01

    A robust backstepping controller was designed based on state reconstruction for flexible air⁃breathing hypersonic ve⁃hicles considering that only the velocity,altitude and pitch rate were observable. Firstly,the controlled plant was rewritten as a strict feedback form,and the actual control laws and virtual control laws were designed based on dynamic inversion and backstepping re⁃spectively. Secondly,arctangent tracking differentiator was introduced to estimate the derivatives of virtual control laws and recon⁃struct the states of flight⁃path angle and angle of attack.Finally,in order to guarantee the backstepping controller'robustness,a new nonlinear disturbance observer was designed based on nonlinear⁃linear tracking differentiator to estimate and compensate uncertain⁃ties of the model precisely.Simulation results show that a high precise state construction can be obtained by the proposed strategy and the presented control methodology can provide a stable altitude and velocity tracking,and eliminate the influence of the uncer⁃tainties of the model.%针对吸气式高超声速飞行器参数不确定弹性体模型,仅考虑速度、高度和俯仰角速度可测的情况,提出了一种基于状态重构的鲁棒反演控制器设计方法。首先,将被控对象模型表示为严格反馈形式,分别采用动态逆和反演设计实际控制律和虚拟控制律;其次,引入反正切跟踪微分器来简化虚拟控制律求导运算,并用于对弹道角和攻角进行状态重构;最后,为了保证反演控制器的鲁棒性,基于非线性⁃线性跟踪微分器,设计了一种新型非线性干扰观测器,可实现对模型不确定项的精确估计和补偿。仿真结果表明,所提策略取得了较高的状态重构精度,控制器能够克服模型不确定项的影响,且能保证速度和高度对参考输入的稳定跟踪。

  17. Non-contact scanning ion conductance microscopy for high-resolution morphological imaging of live cells%非接触式扫描离子电导显微镜技术在探测活体细胞表面微结构中的应用

    Institute of Scientific and Technical Information of China (English)

    杨茜; 刘晓; 马丽颖; 李长峰; 鲍亚盟; 高瑞玲; 张西正; 张彦军

    2009-01-01

    As a new kind of scanning probe microscopy,scanning ion conductance microscopy (SICM) is designed for imaging non-conducting biological sample at the nanometer scale. Firstly, nanometer scale glass micropipettes were pulled successfully, and were functionally evaluated. Secondly, a micropipette-sample approaching curve was obtained for describing the working principle of SICM. Finally, SICM was used to scan the morphology of a conductive standard sample and live renal epithelial A6 cells. The topography of A6 cells monolayer was verified with Scanning Electron Microscopy (SEM) observation. As a result, non-contact SICM can be used not only for scanning conductive samples, but also for acquiring 30 morphological image of non-conducting living cells. It provides a powerful tool for in-depth studying the relationship between the cell membrane microstructures and their physiological functions.%扫描离子电导显微镜技术是在纳米尺度进行非导电的生物样品成像的一种新型扫描探针显微镜技术.通过成功制备扫描离子电导显微镜扫描探测用纳米尺度玻璃微探针,对其进行了功能性评估;而后通过绘制探针-样品接近曲线,阐述了扫描离子电导显微镜技术实现非接触高分辨率探测的工作原理;最后采用该显微镜技术对导电标准样品及活体肾上皮A6细胞进行了表面形貌扫描成像,并与A6细胞表面形貌的扫描电镜图像进行了对照.结果表明,扫描离子电导显微镜技术不仅可实现导电样品的扫描成像,而且适宜于在生理条件下、非接触式地研究活体细胞表面的三维形貌,从而为人们深入研究细胞表面微观结构与生理功能提供了全新的技术手段.

  18. Bone scan in rheumatology

    International Nuclear Information System (INIS)

    In this chapter a revision is made concerning different uses of bone scan in rheumatic diseases. These include reflex sympathetic dystrophy, osteomyelitis, spondyloarthropaties, metabolic bone diseases, avascular bone necrosis and bone injuries due to sports. There is as well some comments concerning pediatric pathology and orthopedics. (authors). 19 refs., 9 figs

  19. Scan This Book!

    Science.gov (United States)

    Albanese, Andrew Richard

    2007-01-01

    In this article, the author presents an interview with Brewster Kahle, leader of the Open Content Alliance (OCA). OCA book scan program is an alternative to Google's library project that aims to make books accessible online. In this interview, Kahle discusses his views on the challenges of getting books on the Web, on Google's library…

  20. Lung gallium scan

    Science.gov (United States)

    ... Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Lung Diseases Nuclear Scans Sarcoidosis Browse the Encyclopedia A.D.A. ...

  1. Surface micromachined scanning mirrors

    DEFF Research Database (Denmark)

    Mattsson, Kent Erik

    1992-01-01

    Both aluminum cantilever and torsional scanning mirrors have been fabricated and their static and dynamic properties are studied experimentally and theoretically. The experiments showed resonance frequencies in the range of 163 k-Hz - 632 kHz for cantilever beams with Q values between 5 and 11. T...

  2. Scanning bubble chamber pictures

    CERN Multimedia

    1974-01-01

    These were taken at the 2 m hydrogen bubble chamber. The photo shows an early Shiva system where the pre-measurements needed to qualify the event were done manually (cf photo 7408136X). The scanning tables were located in bld. 12. Gilberte Saulmier sits on foreground, Inge Arents at centre.

  3. 吸气式高超声速飞行器纵向运动反演控制器设计%Design of Backstepping Controller for Longitudinal Motion of an Air-Breathing Hypersonic Vehicle

    Institute of Scientific and Technical Information of China (English)

    时建明; 王洁; 王琨; 邵雷

    2013-01-01

    针对气动/推进/结构耦合的吸气式高超声速飞行器纵向平面飞行控制问题,提出了基于反演的鲁棒控制器设计方法.利用曲线拟合模型将控制系统表示为反馈形式,采用反演方法设计虚拟和实际控制器,并引入鲁棒微分器估计虚拟控制量的导数,解决了虚拟控制量求导运算复杂的问题.为增强控制器应对不确定项的鲁棒性,设计了超扭曲滑模干扰观测器,实现了对系统模型不确定项的估计和补偿.对吸气式高超声速飞行器一体化原理模型的速度和高度指令跟踪仿真表明,该控制器对拟合误差和外加干扰等系统不确定项具有鲁棒性,系统状态量能够在指令跟踪过程中趋于平衡状态,从而验证了所提方案的有效性.%A robust controller based on backstepping design procedure is proposed for an air-breathing hypersonic vehicle with aerodynamic, propulsion and structural couplings. Expressing the control system as strict feedback form via the curve-fitted model, virtual and actual controllers are constructed for the velocity and altitude subsystems. To omit analytic calculation of the virtual control law derivatives, which is very difficult to evaluate in the traditional backstepping control, robust differentiators are introduced. Super-twisting sliding mode disturbance observers are designed to compensate uncertainties in the system dynamics. Trajectory tracking simulation performed on the first principle model of the vehicle's longitudinal dynamics shows that the designed controllers are robust to model fitting errors and outside disturbances, and the system states reach trimmed condition asymptotically.

  4. Backstepping high order sliding mode control for brushless DC motor speed servo control system%无刷直流电机转速伺服系统反步高阶滑模控制

    Institute of Scientific and Technical Information of China (English)

    张庆超; 马瑞卿

    2016-01-01

    针对无刷直流电机转速伺服系统高性能非线性鲁棒控制,提出一种新型的多滑模反步高阶滑模非线性控制方法。在控制律设计的每一步都引入二阶滑模Super-Twisting算法,无需计算变量导数,消除了滑模抖振,并在第1级子系统虚拟控制律设计中提出一种改进的二阶滑模Super-Twisting算法。与传统双闭环PI控制相比,能够令系统的动静态性能更好,转矩脉动更小,鲁棒性更强;与标准Super-Twisting算法相比,进一步提高了系统对阶跃负载扰动的抑制能力。最后通过仿真分析表明了所提出方法的有效性。%For higher performance speed servo robustness control of brushless DC motor(BLDCM), a novel multiple sliding mode backstepping high order sliding mode nonlinear control approach is proposed. The second order sliding mode Super-Twisting algorithm(STA) ,which needs no derivative of any variables and eliminates the sliding mode chattering, is used in each step design of the whole backstepping control law. And a self-adaption STA(SSTA) is proposed and used in the virtual control law of the first level subsystem. Compared with the traditional dual closed loop PI control, the proposed method makes the system have higher dynamic and static performance, smaller torque ripple and stronger robustness. Compared with the traditional STA, the proposed SSTA can futher improve the system’s robustness for the step load disturbance. Finally, simulation analysis shows the effectiveness of the proposed method.

  5. A Back-Stepping Sliding Mode Control Strategy for Single-Phase Photovoltaic Grid-Connected Inverter%单相光伏并网逆变器的反步滑模控制策略

    Institute of Scientific and Technical Information of China (English)

    游国栋; 李继生; 侯勇; 赵春东

    2015-01-01

    Since the photovoltaic (PV) grid-connected inverter system is easy to be affected by such factors as external interference and the uncertainty of its system parameters, taking the output voltage of filter capacitor and its derivative as state variables and integrating the back-stepping method with sliding mode control, a back-stepping sliding mode control based control strategy for PV grid-connected inverter is proposed, and the feedback control law for the inverter under parameter uncertainty and external interference is derived. To achieve the global maximum power point (MPP) of PV array, an improved particle swarm optimization (PSO) algorithm based maximum power point tracking (MPPT) method is put forward, and the duty ratio is divided into two parts for the initialization, thus a linear relation between the operational power of PV array and the duty ratio is established. The effectiveness of the proposed control strategy is validated by both results of simulation and experiments.%为了克服光伏并网逆变系统受外界干扰和系统参数的不确定性等多种因素的干扰,以逆变器的输出滤波电容电压及其导数为状态变量,将反步法和滑模控制相结合,提出了基于反步滑模控制的光伏并网逆变器控制策略。推导了具有参数不确定和外界干扰情况下的逆变器的反馈控制律。为了获取光伏阵列的全局最大功率点(maximum power point, MPP),提出了一种基于改进粒子群优化算法(particle swarm optimization,PSO)的最大功率点跟踪(maximum power point tracking,MPPT)方法,将占空比分为两部分进行初始化,建立了光伏阵列运行功率与占空比之间的线性关系。仿真和试验结果验证了所提控制策略的有效性。

  6. 磁悬浮球系统的自适应反演滑模控制%Adaptive back-stepping sliding mode control of magnetic levitation ball system

    Institute of Scientific and Technical Information of China (English)

    郑建英; 于占东

    2016-01-01

    磁悬浮球系统是一种典型的开环不稳定系统,为了实现磁悬浮球系统的精确控制,而且使系统更具有实际意义,设计了一种自适应反演滑模控制器。在实际控制系统中,不确定性及外加干扰是未知的,本文基于实际应用,利用该系统的线性化模型,来设计此控制器。实验结果表明:所设计的自适应反演滑模控制器与普通滑模控制器相比,能减小系统的抖振,能较好的实现小球的稳定悬浮并具有良好的动态跟踪性能,与自适应滑模控制器相比,能更好的在实践中应用。%Magnetic levitation ball system is a typical open-loop and unstable system, in order to achieve precise control of the magnetic levitation ball system, and make the system more practical, we design an adaptive back-stepping sliding mode controller. In the actual control system, uncertainties and external disturbances are unknown, we base on the practical application of this system, use a linear model of the system, to design the controller. The results show that:compared with the normal mode controller, the design of adaptive back-stepping sliding mode controller can reduce chattering of the system, can better achieve a stable suspension of the ball and has good dynamic tracking performance, and compared to the adaptive sliding mode controller, the controller we design in this paper can better applied in practice.

  7. 基于名义模型的飞行模拟转台反演滑模控制%Nominal Model-Based Sliding Mode Control with Backstepping for 3-Axis Flight Table

    Institute of Scientific and Technical Information of China (English)

    刘金琨; 孙富春

    2006-01-01

    针对飞行模拟转台这一实际的不确定伺服系统,提出一种新型控制策略,该控制策略是建立在名义模型基础上的一种新型全鲁棒滑模控制器.控制系统由两种控制器构成,一种是针对实际对象的全鲁棒滑模控制器,另一种是针对名义模型的积分反演滑模控制器.采用名义模型与实际对象之间的建模误差设计全鲁棒滑模控制器,采用积分反演滑模控制器来保证控制精度,全鲁棒性能由全局滑模控制器来保证.采用Lyapunov方法实现了两种控制器的稳定性分析.以飞行模拟转台伺服系统为被控对象,针对正弦和阶跃响应的仿真结果表明,采用所提出的控制方法,可实现全局鲁棒性并保证较高的位置跟踪精度.%Based on nominal model, a novel global sliding mode controller (GSMC) with a new control scheme is proposed for a practical uncertain servo system. This control scheme consists of two combined controllers. One is the global sliding mode controller for practical plant, the other is the integral backstepping controller for nominal model. Modeling error between practical plant and nominal model is used to design GSMC. The steady-state control accuracy can be guaranteed by the integral backstepping control law, and the global robustness can be obtained by GSMC. The stability of the proposed controller is proved according to the Lyapunov approach. The simulation results both of sine signal and step signal tracking for 3-axis flight table are investigated to show good position tracking performance and high robustness with respect to large and parameter changes over all the response time.

  8. COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results of the Prospective Phase 2 Trial

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Alexandra D., E-mail: alexdjensen@gmx.de [Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany); Nikoghosyan, Anna V.; Lossner, Karen [Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany); Haberer, Thomas; Jäkel, Oliver [Heidelberg Ion Beam Therapy Centre, Heidelberg (Germany); Münter, Marc W.; Debus, Jürgen [Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)

    2015-09-01

    Purpose: To investigate the effect of intensity modulated radiation therapy (IMRT) and dose-escalated carbon ion (C12) therapy in adenoid cystic carcinoma (ACC) and other malignant salivary gland tumors (MSGTs) of the head and neck. Patients and Methods: COSMIC (combined treatment of malignant salivary gland tumors with intensity modulated radiation therapy and carbon ions) is a prospective phase 2 trial of 24 Gy(RBE) C12 followed by 50 Gy IMRT in patients with pathologically confirmed MSGT. The primary endpoint is mucositis Common Terminology Criteria grade 3; the secondary endpoints are locoregional control (LC), progression-free survival (PFS), overall survival (OS), and toxicity. Toxicity was scored according to the Common Terminology Criteria for Adverse Events version 3; treatment response was scored according to Response Evaluation Criteria in Solid Tumors 1.1. Results: Between July 2010 and August 2011, 54 patients were accrued, and 53 were available for evaluation. The median follow-up time was 42 months; patients with microscopically incomplete resections (R1, n=20), gross residual disease (R2, n=17), and inoperable disease (n=16) were included. Eighty-nine percent of patients had ACC, and 57% had T4 tumors. The most common primary sites were paranasal sinus (34%), submandibular gland, and palate. At the completion of radiation therapy, 26% of patients experienced grade 3 mucositis, and 20 patients reported adverse events of the ear (38%). The most common observed late effects were grade 1 xerostomia (49%), hearing impairment (25%, 2% ipsilateral hearing loss), and adverse events of the eye (20%), but no visual impairment or loss of vision. Grade 1 central nervous system necrosis occurred in 6%, and 1 grade 4 ICA hemorrhage without neurologic sequelae. The best response was 54% (complete response/partial remission). At 3 years, the LC, PFS, and OS were 81.9%, 57.9%, and 78.4%, respectively. No difference was found regarding resection status. The

  9. COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results of the Prospective Phase 2 Trial

    International Nuclear Information System (INIS)

    Purpose: To investigate the effect of intensity modulated radiation therapy (IMRT) and dose-escalated carbon ion (C12) therapy in adenoid cystic carcinoma (ACC) and other malignant salivary gland tumors (MSGTs) of the head and neck. Patients and Methods: COSMIC (combined treatment of malignant salivary gland tumors with intensity modulated radiation therapy and carbon ions) is a prospective phase 2 trial of 24 Gy(RBE) C12 followed by 50 Gy IMRT in patients with pathologically confirmed MSGT. The primary endpoint is mucositis Common Terminology Criteria grade 3; the secondary endpoints are locoregional control (LC), progression-free survival (PFS), overall survival (OS), and toxicity. Toxicity was scored according to the Common Terminology Criteria for Adverse Events version 3; treatment response was scored according to Response Evaluation Criteria in Solid Tumors 1.1. Results: Between July 2010 and August 2011, 54 patients were accrued, and 53 were available for evaluation. The median follow-up time was 42 months; patients with microscopically incomplete resections (R1, n=20), gross residual disease (R2, n=17), and inoperable disease (n=16) were included. Eighty-nine percent of patients had ACC, and 57% had T4 tumors. The most common primary sites were paranasal sinus (34%), submandibular gland, and palate. At the completion of radiation therapy, 26% of patients experienced grade 3 mucositis, and 20 patients reported adverse events of the ear (38%). The most common observed late effects were grade 1 xerostomia (49%), hearing impairment (25%, 2% ipsilateral hearing loss), and adverse events of the eye (20%), but no visual impairment or loss of vision. Grade 1 central nervous system necrosis occurred in 6%, and 1 grade 4 ICA hemorrhage without neurologic sequelae. The best response was 54% (complete response/partial remission). At 3 years, the LC, PFS, and OS were 81.9%, 57.9%, and 78.4%, respectively. No difference was found regarding resection status. The

  10. Classification of jet fuels by fuzzy rule-building expert systems applied to three-way data by fast gas chromatography--fast scanning quadrupole ion trap mass spectrometry.

    Science.gov (United States)

    Sun, Xiaobo; Zimmermann, Carolyn M; Jackson, Glen P; Bunker, Christopher E; Harrington, Peter B

    2011-01-30

    A fast method that can be used to classify unknown jet fuel types or detect possible property changes in jet fuel physical properties is of paramount interest to national defense and the airline industries. While fast gas chromatography (GC) has been used with conventional mass spectrometry (MS) to study jet fuels, fast GC was combined with fast scanning MS and used to classify jet fuels into lot numbers or origin for the first time by using fuzzy rule-building expert system (FuRES) classifiers. In the process of building classifiers, the data were pretreated with and without wavelet transformation and evaluated with respect to performance. Principal component transformation was used to compress the two-way data images prior to classification. Jet fuel samples were successfully classified with 99.8 ± 0.5% accuracy for both with and without wavelet compression. Ten bootstrapped Latin partitions were used to validate the generalized prediction accuracy. Optimized partial least squares (o-PLS) regression results were used as positively biased references for comparing the FuRES prediction results. The prediction results for the jet fuel samples obtained with these two methods were compared statistically. The projected difference resolution (PDR) method was also used to evaluate the fast GC and fast MS data. Two batches of aliquots of ten new samples were prepared and run independently 4 days apart to evaluate the robustness of the method. The only change in classification parameters was the use of polynomial retention time alignment to correct for drift that occurred during the 4-day span of the two collections. FuRES achieved perfect classifications for four models of uncompressed three-way data. This fast GC/fast MS method furnishes characteristics of high speed, accuracy, and robustness. This mode of measurement may be useful as a monitoring tool to track changes in the chemical composition of fuels that may also lead to property changes.

  11. Forensic Scanning Electron Microscope

    Science.gov (United States)

    Keeley, R. H.

    1983-03-01

    The scanning electron microscope equipped with an x-ray spectrometer is a versatile instrument which has many uses in the investigation of crime and preparation of scientific evidence for the courts. Major applications include microscopy and analysis of very small fragments of paint, glass and other materials which may link an individual with a scene of crime, identification of firearms residues and examination of questioned documents. Although simultaneous observation and chemical analysis of the sample is the most important feature of the instrument, other modes of operation such as cathodoluminescence spectrometry, backscattered electron imaging and direct x-ray excitation are also exploited. Marks on two bullets or cartridge cases can be compared directly by sequential scanning with a single beam or electronic linkage of two instruments. Particles of primer residue deposited on the skin and clothing when a gun is fired can be collected on adhesive tape and identified by their morphology and elemental composition. It is also possible to differentiate between the primer residues of different types of ammunition. Bullets may be identified from the small fragments left behind as they pass through the body tissues. In the examination of questioned documents the scanning electron microscope is used to establish the order in which two intersecting ink lines were written and to detect traces of chemical markers added to the security inks on official documents.

  12. 基于修正LuGre模型的反步自适应摩擦补偿控制%Adaptive Backstepping Friction Compensation Control Based on Modified LuGre Model

    Institute of Scientific and Technical Information of China (English)

    梁青; 张剑; 王永

    2011-01-01

    LuGre模型是一种常用的对伺服系统进行动态摩擦建模和补偿的模型.基于一种改进的LuGre模型,建立了伺服系统模型;利用反步自适应控制算法得到系统控制律,并构造Lyapunov函数证明了系统的稳定性;将控制结果方面与传统的前馈PID固定摩擦补偿算法进行比较.仿真结果表明该方法能有效降低摩擦因素的不利影响,且比传统的控制算法具有更高的跟踪精度.%LuGre model has been widely used in servo system for dynamic friction modeling and compensation. Model of servo system was built base on a modified LuGre model. Adaptive backstepping algorithm was used to get the control law, The closed-up system stability was proved according to Lyapunov theory. Compared with tradition feed-forward PID algorithm, the simulation results show that the proposed method can effectively reduce the adverse effect of the friction and improve the system tracking accuracy.

  13. Visualization in Scanning

    International Nuclear Information System (INIS)

    Scanning is essentially a method of making the unknown known, and for the vast majority of scanning work this means making the invisible visible. Visualization is developed as a process involving a model of eye and brain function, display performance and counter performance combined with the spatial frequency components in the object scanned. The performance of a scanner or gamma camera depends in part on its display system and experiments have been performed to determine the fractional change in count-rate which can be perceived by the eye from colour, photoscan and cathode-ray tube displays, for both circular and line sources of radioactivity. For circular sources, colour and photoscan displays are capable of making 10% increases in count-rate perceptible in backgrounds ranging from 5 to 100 counts/s for sources of 1 to 4 cm diameter, whilst cathode-ray tube and black-mark displays show only 20% at best. The results for line sources are also given. In testing for the statistical significance of count-rate differences on a scan, the counts are usually compared for equal areas. On this basis the cathode-ray tube display is only able to show five standard deviations of difference whereas colour and photoscan displays show from 2.5 to 3 standard deviations, levels not usually accepted statistically as significant. It is suggested that if the eye examines the areas surrounding the area of interest then the significance of a count-rate difference may be established more accurately and in general will be increased, thereby accounting for the visualization of apparently 'insignificant' regions. This theory is used to predict the areas of count density which should be visually perceived in the presence of noise, and extended to consider practical display conditions, which have been described in this paper. The performance of a scanner can be considered in terms of its modulation transfer function (derived from a line spread function). Fourier analysis has been performed

  14. Ultrafast scanning tunneling microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Botkin, D.A. [California Univ., Berkeley, CA (United States). Dept. of Physics]|[Lawrence Berkeley Lab., CA (United States)

    1995-09-01

    I have developed an ultrafast scanning tunneling microscope (USTM) based on uniting stroboscopic methods of ultrafast optics and scanned probe microscopy to obtain nanometer spatial resolution and sub-picosecond temporal resolution. USTM increases the achievable time resolution of a STM by more than 6 orders of magnitude; this should enable exploration of mesoscopic and nanometer size systems on time scales corresponding to the period or decay of fundamental excitations. USTM consists of a photoconductive switch with subpicosecond response time in series with the tip of a STM. An optical pulse from a modelocked laser activates the switch to create a gate for the tunneling current, while a second laser pulse on the sample initiates a dynamic process which affects the tunneling current. By sending a large sequence of identical pulse pairs and measuring the average tunnel current as a function of the relative time delay between the pulses in each pair, one can map the time evolution of the surface process. USTM was used to measure the broadband response of the STM`s atomic size tunnel barrier in frequencies from tens to hundreds of GHz. The USTM signal amplitude decays linearly with the tunnel junction conductance, so the spatial resolution of the time-resolved signal is comparable to that of a conventional STM. Geometrical capacitance of the junction does not appear to play an important role in the measurement, but a capacitive effect intimately related to tunneling contributes to the measured signals and may limit the ultimate resolution of the USTM.

  15. Nuclear Medicine Scans for Cancer

    Science.gov (United States)

    ... My ACS » Your Local Offices Close + - Text Size Nuclear Medicine Scans for Cancer Other names for these ... inflammation, or cancer. Use of monoclonal antibodies in nuclear scans A special type of antibody made in ...

  16. Scanned-cantilever atomic force microscope with large scanning range

    Institute of Scientific and Technical Information of China (English)

    Jintao Yang; Wendong Xu

    2006-01-01

    A scanned-cantilever atomic force microscope (AFM) with large scanning range is proposed, which adopts a new design named laser spot tracking. The scanned-cantilever AFM uses the separate flexure x-y scanner and z scanner instead of the conventional piezoelectric tube scanner. The closed-loop control and integrated capacitive sensors of these scanners can insure that the images of samples have excellent linearity and stability. According to the experimental results, the scanned-cantilever AFM can realize maximal 100 × 100 (μm) scanning range, and 1-nm resolution in z direction, which can meet the requirements of large scale sample testing.

  17. Quadrature wavelength scanning interferometry.

    Science.gov (United States)

    Moschetti, Giuseppe; Forbes, Alistair; Leach, Richard K; Jiang, Xiang; O'Connor, Daniel

    2016-07-10

    A novel method to double the measurement range of wavelength scanning interferometery (WSI) is described. In WSI the measured optical path difference (OPD) is affected by a sign ambiguity, that is, from an interference signal it is not possible to distinguish whether the OPD is positive or negative. The sign ambiguity can be resolved by measuring an interference signal in quadrature. A method to obtain a quadrature interference signal for WSI is described, and a theoretical analysis of the advantages is reported. Simulations of the advantages of the technique and of signal errors due to nonideal quadrature are discussed. The analysis and simulation are supported by experimental measurements to show the improved performances. PMID:27409307

  18. A Scanning Cavity Microscope

    CERN Document Server

    Mader, Matthias; Hänsch, Theodor W; Hunger, David

    2014-01-01

    Imaging of the optical properties of individual nanosystems beyond fluorescence can provide a wealth of information. However, the minute signals for absorption and dispersion are challenging to observe, and only specialized techniques requiring sophisticated noise rejection are available. Here we use signal enhancement in a scanning optical microcavity to demonstrate ultra-sensitive imaging. Harnessing multiple interactions of probe light with a sample within an optical resonator, we achieve a 1700-fold signal enhancement compared to diffraction-limited microscopy. We demonstrate quantitative imaging of the extinction cross section of gold nanoparticles with a sensitivity below 1 nm2, we show a method to improve spatial resolution potentially below the diffraction limit by using higher order cavity modes, and we present measurements of the birefringence and extinction contrast of gold nanorods. The demonstrated simultaneous enhancement of absorptive and dispersive signals promises intriguing potential for opt...

  19. Telescopic horizon scanning.

    Science.gov (United States)

    Koenderink, Jan

    2014-12-20

    The problem of "distortionless" viewing with terrestrial telescopic systems (mainly "binoculars") remains problematic. The so called "globe effect" is only partially counteracted in modern designs. Theories addressing the phenomenon have never reached definitive closure. In this paper, we show that exact distortionless viewing with terrestrial telescopic systems is not possible in general, but that it is in principle possible in-very frequent in battle field and marine applications-the case of horizon scanning. However, this involves cylindrical optical elements. For opto-electronic systems, a full solution is more readily feasible. The solution involves a novel interpretation of the relevant constraints and objectives. For final design decisions, it is not necessary to rely on a corpus of psychophysical (or ergonomic) data, although one has to decide whether the instrument is intended as an extension of the eye or as a "pictorial" device. PMID:25608206

  20. Micro scanning probes

    CERN Document Server

    Niblock, T

    2001-01-01

    This thesis covers the design methodology, theory, modelling, fabrication and evaluation of a Micro-Scanning-Probe. The device is a thermally actuated bimorph quadrapod fabricated using Micro Electro Mechanical Systems technology. A quadrapod is a structure with four arms, in this case a planar structure with the four arms forming a cross which is dry etched out of a silicon diaphragm. Each arm has a layer of aluminium deposited on it forming a bimorph. Through heating each arm actuation is achieved in the plane of the quadrapod and the direction normal to it. Fabrication of the device has required the development of bulk micromachining techniques to handle post CMOS fabricated wafers and the patterning of thickly sputtered aluminium in bulk micro machined cavities. CMOS fabrication techniques were used to incorporate diodes onto the quadrapod arms for temperature measurement of the arms. Fine tungsten and silicon tips have also been fabricated to allow tunnelling between the tip and the platform at the centr...

  1. Scan mirrors relay for high resolution laser scanning systems

    Science.gov (United States)

    Kessler, David

    2014-09-01

    Two dimensional beam deflection is often required in medical laser scanning systems such as OCT or confocal microscopy. Commonly two linear galvo mirrors are used for performance in terms of their large apertures and scan angles. The galvo mirrors are placed at the vicinity of entrance pupil of the scan lens with a "displacement distance" separating them. This distance limits the scan fields and/or reduces the effective aperture of the scan lens. Another option is to use a beam or pupil relay, and image one galvo mirror onto the other. However, beam (or pupil) relays are notoriously complicated, expensive and can add significant aberrations. This paper discusses a simple, all reflective, diffraction limited, color corrected, beam relay, capable of large scan angles and large deflecting mirrors. The design is based on a unique combination of an Offner configuration with a Schmidt aspheric corrector. The design is highly corrected up to large scan mirrors and large scan angles down to milliwaves of aberrations. It allows significantly larger scan field and or scan lenses with higher numerical aperture as compared with scanners using galvos separated by the displacement distance. While this relay is of exceptionally high performance, it has one element located where the beam is focused which may present a problem for high power lasers. Thus modifications of the above design are introduced where the beam is focused in mid air thus making it usable for high power systems such including laser marking and fabrication systems.

  2. IMM Based Adaptive Backstepping Variable Structure Fault-Tolerant Control for Spacecraft with Reaction Wheel Dynamics%轮控航天器的IMM自适应反步变结构容错控制

    Institute of Scientific and Technical Information of China (English)

    马广富; 王宇雷; 李传江; 张海博

    2011-01-01

    A new adaptive backstepping variable structure control combined with interactive multiple model ( IMM)method is proposed in this paper for the attitude maneuver problem of rigid spacecraft in the presence of actuator faults, uncertainties of moment af inertia and external disturbance torques. The algorithm can guarantee attitude maneuver errors converged to a smatl set around the equilibrium point. limit the chatter of variable structure control caused hy actuator faults and reduce the impact of diagnostical uncertainty on system. By using Matlab/Simulink programming, modeling and simulation of spacecraft attitude maneuver are also discussed in the paper. Simulation results demonstrate the effectiveness and feasibility of the proposed control algorithm.%针对存在飞轮故障、转动惯量不确定性和干扰力矩的轮控航天器姿态机动问题,提出了一种基于交互多模型算法(IMM)的自适应反步变结构容错控制方法.该方法可以有效提高系统控制精度,保航天器姿态机动误差收敛到系统平衡点的较小邻域;同时有效减小飞轮抖振,降低诊断不确定性对系统的影响.最后在Matlab/Simulink环境下对航天器姿态机动进行了仿真研究,结果表明了提出的控制算法在处理航天器姿态机动问题方面的有效性和可行性.

  3. Adaptive backstepping control for an air-breathing hypersonic vehicle with input constraints%吸气式高超声速飞行器输入受限自适应反演控制

    Institute of Scientific and Technical Information of China (English)

    时建明; 王洁; 叶继坤; 邵雷

    2012-01-01

    The issues of flight control of an air-breathing hypersonic vehicle with constrained inputs and uncertain aerodynamic coefficients were addressed. Based on backstepping procedure, virtual and actual controllers were designed for linearly parameterized form of the vehicle longitudinal motion model. To deal with uncertain parametric coefficients, on-line adaptive bounding learning scheme was selected. Considering input constraints condition, tracking errors were modified by introducing margin filtering terms of designed controllers and executable inputs. Stability analysis was implemented to prove the effectiveness of the proposed method. Reference trajectory tracking simulation results demonstrate the effectiveness of the control law design under wind disturbance.%针对输入受限和气动与推进参数存在不确定时的吸气式高超声速飞行器飞行控制问题,建立了线性参数化形式的纵向运动模型,通过引入控制量与可执行输入之间的差值滤波环节,修正跟踪误差的定义,设计了使闭环系统稳定的反演鲁棒控制器,给出了气动与推进参数向量的有界自适应估计律.轨迹跟踪仿真结果表明,提出的自适应控制方法能够保证阵风干扰情况下飞行器控制的稳定性.

  4. 自适应反演滑模控制在火箭炮交流伺服系统中的应用%Application of Adaptive Backstepping Sliding Mode Controlin in Alternative Current Servo System of Rocket Gun

    Institute of Scientific and Technical Information of China (English)

    郭亚军; 王晓锋; 马大为; 乐贵高

    2011-01-01

    A adaptive backstepping sliding mode control approach was introduced to control the pitch motion of a rocket gun. Its control law was proposed to guarantee that the control system was ultimately bounded in a Lyapunov sense and make the servo system could track the instruction of reference position globally and asymptotically. In addition, the sliding mode control can restrain effects of parameter uncertainties and external disturbance. The functions of adaptive mechanism and sliding mode control were analyzed by using simulation under different conditions. The simulation results illustrate that the method is applicable and robust.%针对某火箭炮俯仰运动的位置控制问题,采用了一种自适应反演滑模控制方法.自适应反演控制律保证了闭环系统最终有界,使伺服系统能够全局渐进跟踪参考位置指令,从而达到交流伺服系统稳定跟踪控制的目的,滑模控制抑制了模型参数摄动和外界干扰的影响.通过不同条件下的仿真研究,分析了自适应机制和滑模控制在运动控制中的作用,结果表明该方法具有较强的适应性及鲁棒性.

  5. 液力自动变速器换挡过程的反演优化控制%Optimizing gear shifting quality with backstepping control for automatic transmission

    Institute of Scientific and Technical Information of China (English)

    赵鑫鑫; 杨珏; 张静; 张文明

    2016-01-01

    The Automatic Transmission is widely equipped in the heavy-duty trucks, while the driving comfort reduction during gear shift is the major drawbacks, and the optimization of gear shifting process is quite challenging due to the various objectives. With the development of modern control theory, it has been widely applied into gear shifting duration, such as PID control, genetic algorithm and dynamic programming et al. In this paper, a backstepping control strategy is proposed to enhance the gear shift quality, which will transform the multi-objective optimization to a single target tracking as well. According to the gear shifting dynamic model, gear shifting can be divided into four phases, lower gear phase, torque phase, inertial phase and higher gear phase. The clutch output torques during engagement and disengagement are derived considering the motion states of the off-going and on-coming clutches. The trajectory target is defined on the basis of the rotatory input and output speed of the transmission. Since the torque is hard to be measured accurately and the transmission output speed does not has obvious change during the torque phase of gear shifting, we will adjust the current of pressure reducing valves in the inertial phase. By analyzing the motion states of off-going clutch and on-coming clutch, the mathematical model of output torque for clutches has been built in this paper. The backstepping method and state stability theory (ISS) are utilized in the sliding mode controller to control the synchronization torques by tuning the valves current. The shifting quality is assessed in terms of the shift time, jerk and sliding friction work which are considered into the objective function in sliding control problem. All of them are fitted as three-order polynomial functions, and the controller parameters are evaluated according to the system parameters and the margin of errors. Based on the reference trajectory, the speed of driven plate on-coming clutch

  6. Radionuclide brain scanning

    International Nuclear Information System (INIS)

    At one stage of medical imaging development, radionuclide brain scanning was the only technique available for imaging of the brain. Advent of CT and MRI pushed it to the background. It regained some of the grounds lost to ''allied advances'' with the introduction of brain perfusion radiopharmaceuticals. Positron emission tomography is a promising functional imaging modality that at present will remain as a research tool in special centres in developed countries. However, clinically useful developments will gradually percolate from PET to SPECT. The non-nuclear imaging methods are totally instrument dependent; they are somewhat like escalators, which can go that far and no further. Nuclear imaging has an unlimited scope for advance because of the new developments in radiopharmaceuticals. As the introduction of a radiopharmaceutical is less costly than buying new instruments, the recent advances in nuclear imaging are gradually perfusing through the developing countries also. Therefore, it is essential to follow very closely PET developments because what is research today might become routine tomorrow

  7. LANL Robotic Vessel Scanning

    Energy Technology Data Exchange (ETDEWEB)

    Webber, Nels W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-25

    Los Alamos National Laboratory in J-1 DARHT Operations Group uses 6ft spherical vessels to contain hazardous materials produced in a hydrodynamic experiment. These contaminated vessels must be analyzed by means of a worker entering the vessel to locate, measure, and document every penetration mark on the vessel. If the worker can be replaced by a highly automated robotic system with a high precision scanner, it will eliminate the risks to the worker and provide management with an accurate 3D model of the vessel presenting the existing damage with the flexibility to manipulate the model for better and more in-depth assessment.The project was successful in meeting the primary goal of installing an automated system which scanned a 6ft vessel with an elapsed time of 45 minutes. This robotic system reduces the total time for the original scope of work by 75 minutes and results in excellent data accumulation and transmission to the 3D model imaging program.

  8. Hyperchromatic laser scanning cytometry

    Science.gov (United States)

    Tárnok, Attila; Mittag, Anja

    2007-02-01

    In the emerging fields of high-content and high-throughput single cell analysis for Systems Biology and Cytomics multi- and polychromatic analysis of biological specimens has become increasingly important. Combining different technologies and staining methods polychromatic analysis (i.e. using 8 or more fluorescent colors at a time) can be pushed forward to measure anything stainable in a cell, an approach termed hyperchromatic cytometry. For cytometric cell analysis microscope based Slide Based Cytometry (SBC) technologies are ideal as, unlike flow cytometry, they are non-consumptive, i.e. the analyzed sample is fixed on the slide. Based on the feature of relocation identical cells can be subsequently reanalyzed. In this manner data on the single cell level after manipulation steps can be collected. In this overview various components for hyperchromatic cytometry are demonstrated for a SBC instrument, the Laser Scanning Cytometer (Compucyte Corp., Cambridge, MA): 1) polychromatic cytometry, 2) iterative restaining (using the same fluorochrome for restaining and subsequent reanalysis), 3) differential photobleaching (differentiating fluorochromes by their different photostability), 4) photoactivation (activating fluorescent nanoparticles or photocaged dyes), and 5) photodestruction (destruction of FRET dyes). With the intelligent combination of several of these techniques hyperchromatic cytometry allows to quantify and analyze virtually all components of relevance on the identical cell. The combination of high-throughput and high-content SBC analysis with high-resolution confocal imaging allows clear verification of phenotypically distinct subpopulations of cells with structural information. The information gained per specimen is only limited by the number of available antibodies and by sterical hindrance.

  9. Re-scan confocal microscopy: scanning twice for better resolution

    NARCIS (Netherlands)

    G.M.R. De Luca; R.M.P. Breedijk; R.A.J. Brandt; C.H.C. Zeelenberg; B.E. de Jong; W. Timmermans; L.N. Azar; R.A. Hoebe; S. Stallinga; E.M.M. Manders

    2013-01-01

    We present a new super-resolution technique, Re-scan Confocal Microscopy (RCM), based on standard confocal microscopy extended with an optical (re-scanning) unit that projects the image directly on a CCD-camera. This new microscope has improved lateral resolution and strongly improved sensitivity wh

  10. Scanning tunneling microscopy II further applications and related scanning techniques

    CERN Document Server

    Güntherodt, Hans-Joachim

    1995-01-01

    Scanning Tunneling Microscopy II, like its predecessor, presents detailed and comprehensive accounts of the basic principles and broad range of applications of STM and related scanning probe techniques. The applications discussed in this volume come predominantly from the fields of electrochemistry and biology. In contrast to those described in STM I, these studies may be performed in air and in liquids. The extensions of the basic technique to map other interactions are described in chapters on scanning force microscopy, magnetic force microscopy, and scanning near-field optical microscopy, together with a survey of other related techniques. Also described here is the use of a scanning proximal probe for surface modification. Together, the two volumes give a comprehensive account of experimental aspects of STM. They provide essential reading and reference material for all students and researchers involved in this field. In this second edition the text has been updated and new methods are discussed.

  11. Scanning tunneling microscopy II further applications and related scanning techniques

    CERN Document Server

    Güntherodt, Hans-Joachim

    1992-01-01

    Scanning Tunneling Microscopy II, like its predecessor, presents detailed and comprehensive accounts of the basic principles and broad range of applications of STM and related scanning probe techniques. The applications discussed in this volume come predominantly from the fields of electrochemistry and biology. In contrast to those described in Vol. I, these sudies may be performed in air and in liquids. The extensions of the basic technique to map other interactions are described inchapters on scanning force microscopy, magnetic force microscopy, scanning near-field optical microscopy, together with a survey of other related techniques. Also described here is the use of a scanning proximal probe for surface modification. Togehter, the two volumes give a comprehensive account of experimental aspcets of STM. They provide essentialreading and reference material for all students and researchers involvedin this field.

  12. Bone Densitometry (Bone Density Scan)

    Science.gov (United States)

    ... of DXA Bone Densitometry? What is a Bone Density Scan (DXA)? Bone density scanning, also called dual-energy x-ray absorptiometry ( ... is today's established standard for measuring bone mineral density (BMD). An x-ray (radiograph) is a noninvasive ...

  13. Gas and metal ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Oaks, E. [High Current Electronics Institute, Tomsk (Russian Federation)]|[State Academy of Control System and Radioelectronics, Tomsk (Russian Federation); Yushkov, G. [High Current Electronics Institute, Tomsk (Russian Federation)

    1996-08-01

    The positive ion sources are now of interest owing to both their conventional use, e.g., as injectors in charged-particle accelerators and the promising capabilities of intense ion beams in the processes related to the action of ions on various solid surfaces. For industrial use, the sources of intense ion beams and their power supplies should meet the specific requirements as follows: They should be simple, technologically effective, reliable, and relatively low-cost. Since the scanning of an intense ion beam is a complicated problem, broad ion beams hold the greatest promise. For the best use of such beams it is desirable that the ion current density be uniformly distributed over the beam cross section. The ion beam current density should be high enough for the treatment process be accomplished for an acceptable time. Thus, the ion sources used for high-current, high-dose metallurgical implantation should provide for gaining an exposure dose of {approximately} 10{sup 17} cm{sup {minus}2} in some tens of minutes. So the average ion current density at the surface under treatment should be over 10{sup {minus}5} A/cm{sup 2}. The upper limit of the current density depends on the admissible heating of the surface under treatment. The accelerating voltage of an ion source is dictated by its specific use; it seems to lie in the range from {approximately}1 kV (for the ion source used for surface sputtering) to {approximately}100 kV and over (for the ion sources used for high-current, high-dose metallurgical implantation).

  14. Application for the On-line Isotope Mass Separator ISOLDE Facility: the Mass Scan

    CERN Document Server

    Sánchez-Conejo, Jorge

    2003-01-01

    The purpose of the Mass Scan Application is to scan the mass of the ion beam that passes through the GPS (General Purpose Separator) on the On-Line Isotope Mass Separator ISOLDE facility. The application has been developed in Java, making use of the Java Development Kit 1.4 and the PS Java environment.

  15. Ion Colliders

    CERN Document Server

    Fischer, W

    2014-01-01

    High-energy ion colliders are large research tools in nuclear physics to study the Quark-Gluon-Plasma (QGP). The range of collision energy and high luminosity are important design and operational considerations. The experiments also expect flexibility with frequent changes in the collision energy, detector fields, and ion species. Ion species range from protons, including polarized protons in RHIC, to heavy nuclei like gold, lead and uranium. Asymmetric collision combinations (e.g. protons against heavy ions) are also essential. For the creation, acceleration, and storage of bright intense ion beams, limits are set by space charge, charge change, and intrabeam scattering effects, as well as beam losses due to a variety of other phenomena. Currently, there are two operating ion colliders, the Relativistic Heavy Ion Collider (RHIC) at BNL, and the Large Hadron Collider (LHC) at CERN.

  16. Development of a focused ion beam micromachining system

    Energy Technology Data Exchange (ETDEWEB)

    Pellerin, J.G.; Griffis, D.; Russell, P.E.

    1988-12-01

    Focused ion beams are currently being investigated for many submicron fabrication and analytical purposes. An FIB micromachining system consisting of a UHV vacuum system, a liquid metal ion gun, and a control and data acquisition computer has been constructed. This system is being used to develop nanofabrication and nanomachining techniques involving focused ion beams and scanning tunneling microscopes.

  17. Re-scan confocal microscopy: scanning twice for better resolution.

    Science.gov (United States)

    De Luca, Giulia M R; Breedijk, Ronald M P; Brandt, Rick A J; Zeelenberg, Christiaan H C; de Jong, Babette E; Timmermans, Wendy; Azar, Leila Nahidi; Hoebe, Ron A; Stallinga, Sjoerd; Manders, Erik M M

    2013-01-01

    We present a new super-resolution technique, Re-scan Confocal Microscopy (RCM), based on standard confocal microscopy extended with an optical (re-scanning) unit that projects the image directly on a CCD-camera. This new microscope has improved lateral resolution and strongly improved sensitivity while maintaining the sectioning capability of a standard confocal microscope. This simple technology is typically useful for biological applications where the combination high-resolution and high-sensitivity is required.

  18. Ion colliders

    International Nuclear Information System (INIS)

    Ion colliders are research tools for high-energy nuclear physics, and are used to test the theory of Quantum Chromo Dynamics (QCD). The collisions of fully stripped high-energy ions create matter of a temperature and density that existed only microseconds after the Big Bang. Ion colliders can reach higher densities and temperatures than fixed target experiments although at a much lower luminosity. The first ion collider was the CERN Intersecting Storage Ring (ISR), which collided light ions (77Asb1, 81Bou1). The BNL Relativistic Heavy Ion Collider (RHIC) is in operation since 2000 and has collided a number of species at numerous energies. The CERN Large Hadron Collider (LHC) started the heavy ion program in 2010. Table 1 shows all previous and the currently planned running modes for ISR, RHIC, and LHC. All three machines also collide protons, which are spin-polarized in RHIC. Ion colliders differ from proton or antiproton colliders in a number of ways: the preparation of the ions in the source and the pre-injector chain is limited by other effects than for protons; frequent changes in the collision energy and particle species, including asymmetric species, are typical; and the interaction of ions with each other and accelerator components is different from protons, which has implications for collision products, collimation, the beam dump, and intercepting instrumentation devices such a profile monitors. In the preparation for the collider use the charge state Z of the ions is successively increased to minimize the effects of space charge, intrabeam scattering (IBS), charge change effects (electron capture and stripping), and ion-impact desorption after beam loss. Low charge states reduce space charge, intrabeam scattering, and electron capture effects. High charge states reduce electron stripping, and make bending and acceleration more effective. Electron stripping at higher energies is generally more efficient. Table 2 shows the charge states and energies in the

  19. Establishing an Environmental Scanning Process.

    Science.gov (United States)

    Morrison, James L.

    1985-01-01

    A formal environmental scanning system designed to identify emerging issues, events, or trends threatening or bringing opportunity to an institution is discussed that uses a committee to systematically collect and analyze data from a variety of sources. (MSE)

  20. Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor

    OpenAIRE

    NOZAKI, Kazuyoshi; TARUI, Akira; OSAKA, Issey; Kawasaki, Hideya; ARAKAWA, Ryuichi; 荒川, 隆一

    2010-01-01

    The effects of an on-line ion suppressor device on alkali metal ion adduct formations of the model compound tacrolimus were investigated. The base peak ion in the positive ion ESI-MS spectrum of tacrolimus was a sodium ion adduct, [M+Na]+. On the other hand, an ammonium ion adduct, [M+NH4]+, was the base peak ion in the full-scan mass spectrum of tacrolimus with a cation-exchange suppressor resin, and both [M+Na]+ and [M+K]+ were eliminated. These results indicate that the combination of an o...

  1. Scanning electron microscopy of biomaterials

    OpenAIRE

    McKinlay, K.J.; Scotchford, C A; Grant, D M; Oliver, J M; King, John R.; Brown, Paul D.

    2004-01-01

    A comparison of conventional high vacuum scanning electron microscopy (HVSEM), environmental SEM (ESEM) and confocal laser scanning microscopy (CLSM) in the assessment of cell-material interactions is made. The processing of cells cultured for conventional HVSEM leads to the loss of morphological features that are retained when using ESEM. The use of ESEM in conjunction with CLSM of the labeled cytoskeleton gives an indication of changes to the cell morphology as a consequence of incubation t...

  2. Air-ion counter and mobility spectrometer

    International Nuclear Information System (INIS)

    Mono-electrode self “zeroing” air-ion counter and mobility (size) scanning spectrometer (CDI-011) based on the Gerdien aspirated condenser principle has been developed. Instrument is intended for short- and long-term indoor and outdoor air-ion concentration measurements and scanning of air-ions by mobility. Measuring small currents (typically 10−14 A) generated by the air-ions in outdoor conditions is demanding and causes many problems related to change of temperature, relative humidity, wind and electromagnetic noise. Also, measuring of both ion polarities with mono electrode detector require alternate changes of the polarizing voltage sign which produces capacitive current spikes. Various techniques, including “zeroing” method, have been applied to successfully overcome most of these measuring interferences.

  3. Air-ion counter and mobility spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Kolarz, Predrag, E-mail: kolarz@ipb.ac.rs [Institute of Physics, University of Belgrade, Pregrevica 118, 11080 Belgrade (Serbia); Miljkovic, Budimir [Merni Instrumenti D.O.O., Ljube Stojanovica 38, 11000 Belgrade (Serbia); Curguz, Zoran [Faculty of Transport and Traffic Engineering, University of East Sarajevo, Vojvode Misica 52, 74000 Doboj (Bosnia and Herzegowina)

    2012-05-15

    Mono-electrode self 'zeroing' air-ion counter and mobility (size) scanning spectrometer (CDI-011) based on the Gerdien aspirated condenser principle has been developed. Instrument is intended for short- and long-term indoor and outdoor air-ion concentration measurements and scanning of air-ions by mobility. Measuring small currents (typically 10{sup -14} A) generated by the air-ions in outdoor conditions is demanding and causes many problems related to change of temperature, relative humidity, wind and electromagnetic noise. Also, measuring of both ion polarities with mono electrode detector require alternate changes of the polarizing voltage sign which produces capacitive current spikes. Various techniques, including 'zeroing' method, have been applied to successfully overcome most of these measuring interferences.

  4. Sub-Kelvin scanning tunneling microscopy on magnetic molecules

    OpenAIRE

    Zhang, Lei

    2012-01-01

    Magnetic molecules have attracted lots interest. In this work, an ultra-stable and low noise scanning tunneling microscopy operating at 400 mK using He-3 (930 mK using He-4) has been developed. The magnetic behavior of different magnetic molecules on substrates, especially the exchange interaction between the magnetic ions, the magnetic anisotropy on the surface, the magnetic excitations as well as the Kondo effect, were studied by using STM.

  5. Ion Chromatography.

    Science.gov (United States)

    Mulik, James D.; Sawicki, Eugene

    1979-01-01

    Accurate for the analysis of ions in solution, this form of analysis enables the analyst to directly assay many compounds that previously were difficult or impossible to analyze. The method is a combination of the methodologies of ion exchange, liquid chromatography, and conductimetric determination with eluant suppression. (Author/RE)

  6. Residual biomass for removal of uranyl ions;Biomassa residual para remocao de ions uranilo

    Energy Technology Data Exchange (ETDEWEB)

    Boniolo, Milena Rodrigues [Universidade Federal de Sao Carlos (UFScar), SP (Brazil). Dept. de Biogeoquimica Ambiental; Yamaura, Mitiko; Monteiro, Raquel Almeida, E-mail: milenaboniolo@usp.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Quimica e Meio Ambiente

    2010-07-01

    Activities related to nuclear industry, production of phosphoric acid and hospitals have generated considerable volumes of radioactive waste containing uranyl ions. Banana pith was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy and was investigated as a biosorbent for uranyl ions from nitric solutions by batch experiments. Influences of adsorbent size, kinetics and equilibrium adsorption were studied. The biosorption of the uranyl ions followed pseudo-second-order kinetics. The adsorption isotherm data were closely fitted to the Freundlich equation. (author)

  7. Environmental Scanning and the Information Manager.

    Science.gov (United States)

    Newsome, James; McInerney, Claire

    1990-01-01

    Discusses nine components of an environmental scanning model: selecting the scanning team; selecting resources to scan; choosing criteria for scanning; scanning the resources; identifying signals of new issues; selecting key events/issues; monitoring and analyzing events/issues; disseminating information; and deciding on appropriate organizational…

  8. Holders for in situ treatments of scanning tunneling microscopy tips.

    Science.gov (United States)

    Ishida, Nobuyuki; Subagyo, Agus; Ikeuchi, Akira; Sueoka, Kazuhisa

    2009-09-01

    We have developed holders for scanning tunneling microscopy tips that can be used for in situ treatments of the tips, such as electron bombardment (EB) heating, ion sputtering, and the coating of magnetic materials. The holders can be readily installed into the transfer paths and do not require any special type of base stages. Scanning electron microscopy is used to characterize the tip apex after EB heating. Also, spin-polarized scanning tunneling spectroscopy using an Fe coated W tip on the Cr(001) single crystal surface is performed in order to confirm both the capability of heating a tip up to about 2200 K and the spin sensitivity of the magnetically coated tip.

  9. Interesting bone scans - unusual findings

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, M.; Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Wollongong Hospital, Wollongong, NSW (Australia)

    1997-12-01

    A 59-year-old female with carcinoma of the colon and known liver metastatic disease was referred for bone scan to evaluate for bone metastases. Although no bone metastases were found, there was abnormal uptake noted in the liver corresponding to a metastatic calcified lesion. The only other findings were of degenerative disease in the cervical spine, right shoulder and small joints of the hands. A 69-year-old male with carcinoma of the prostate and right side low back pain was referred for bone scan. No focal abnormalities to suggest metastatic disease were identified; findings within the cervical spine, lumber spine and knees were presumed secondary to degenerative disease. Intermittent pain persisted and the patient was referred for a repeat bone scan six months later. Previous scan findings of degenerative disease and no metastatic disease were confirmed; however, closer inspection revealed an enlarged right kidney with significant retention of tracer in the pelvicalyceal system suggesting possible obstruction. A Retrograde pyelogram was performed, and no obvious obstruction demonstrated. As bone scan findings were very suggestive of obstruction, a DTPA scan with lasix was performed showing a dilated right collecting system with no functional obstruction. Given the degree of dilation, it is possible that the patient experiences intermittent PUJ obstruction causing his symptoms. A 33-year-old male with insulin dependent diabetes mellitus and viral arthritis was referred for a bone scan. A three phase revealed increased uptake in the region of the knee and leR proximal tibia. Delayed whole body images revealed multiple focal areas of osteoblastic activity in the leR tibia. Abnormal uptake was also seen in the upper third of the leR femur. The remainder of the skeletal survey was normal. X-ray correlation of the leR tibia and femoral findings was undertaken. Combinating unilateral changes on bone scan and X-ray although very suggestive of sclerotic polyostotic

  10. The boundary-scan handbook

    CERN Document Server

    Parker, Kenneth P

    2016-01-01

    Aimed at electronics industry professionals, this 4th edition of the Boundary Scan Handbook describes recent changes to the IEEE1149.1 Standard Test Access Port and Boundary-Scan Architecture. This updated edition features new chapters on the possible effects of the changes on the work of the practicing test engineers and the new 1149.8.1 standard. Anyone needing to understand the basics of boundary scan and its practical industrial implementation will need this book. Provides an overview of the recent changes to the 1149.1 standard and the effect of the changes on the work of test engineers;   Explains the new IEEE 1149.8.1 subsidiary standard and applications;   Describes the latest updates on the supplementary IEEE testing standards. In particular, addresses: IEEE Std 1149.1                      Digital Boundary-Scan IEEE Std 1149.4                      Analog Boundary-Scan IEEE Std 1149.6                      Advanced I/O Testing IEEE Std 1149.8.1           �...

  11. Scanning Terahertz Heterodyne Imaging Systems

    Science.gov (United States)

    Siegel, Peter; Dengler, Robert

    2007-01-01

    Scanning terahertz heterodyne imaging systems are now at an early stage of development. In a basic scanning terahertz heterodyne imaging system, (see Figure 1) two far-infrared lasers generate beams denoted the local-oscillator (LO) and signal that differ in frequency by an amount, denoted the intermediate frequency (IF), chosen to suit the application. The LO beam is sent directly to a mixer as one of two inputs. The signal beam is focused to a spot on or in the specimen. After transmission through or reflection from the specimen, the beams are focused to a spot on a terahertz mixer, which extracts the IF outputs. The specimen is mounted on a translation stage, by means of which the focal spot is scanned across the specimen to build up an image.

  12. Calculation of Uniform of Beam Scanning

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    For the electron beam application, it is always scanned by a dipole magnet. The uniform of the scanning has great influence for some application, such as the irradiation of the thyristor. There are two methods for improving the scanning uniform:

  13. What Is a Nuclear Heart Scan?

    Science.gov (United States)

    ... from the NHLBI on Twitter. What Is a Nuclear Heart Scan? A nuclear heart scan is a test that provides important ... use it to create pictures of your heart. Nuclear heart scans are used for three main purposes: ...

  14. Children, CT Scan and Radiation

    OpenAIRE

    Morteza Bajoghli; Farshad Bajoghli; Nazila Tayari; Reza Rouzbahani

    2010-01-01

    Children are more sensitive to radiation than adults. Computer-ized tomography (CT) consists of 25 % of all medical imaging. It was estimated that more than 2% of all carcinomas in the USA are due to CT scans. There is an ongoing focus on the reduction of CT scan radiation dose. Awareness about risk-benefits of CT has increased. Reduction of radiological exam is an important issue because the accumulation effects of radiation can be hazardous. In addition, proper protocol should be followed f...

  15. RPC High Voltage Scan 2015

    CERN Document Server

    CMS Collaboration

    2016-01-01

    During the LS1 the CMS RPC system has been upgraded with 144 new chambers installed on the forth endcap stations. An annual HV (RPC efficiency vs HV) scan for the entire RPC system has been performed during the Run2 data taking period in 2015. The obtained results have been compared to the HV scans performed in 2011 and 2012. No significant differences are observed in the compared results. The optimal HV working points for the newly installed chambers have been evaluated for the first time with collision data.

  16. Producing colour pictures from SCAN

    International Nuclear Information System (INIS)

    The computer code SCAN.TSK has been written for use on the Interdata 7/32 minicomputer which will convert the pictures produced by the SCAN program into colour pictures on a colour graphics VDU. These colour pictures are a more powerful aid to detecting errors in the MONK input data than the normal lineprinter pictures. This report is intended as a user manual for using the program on the Interdata 7/32, and describes the method used to produce the pictures and gives examples of JCL, input data and of the pictures that can be produced. (U.K.)

  17. Intelligent nonlinear control for the hypersonic morphing vehicle based on the backstepping method%基于回馈递推的可变翼高超声速飞行器智能非线性控制

    Institute of Scientific and Technical Information of China (English)

    吴雨珊; 江驹; 甄子洋; 顾臣风

    2016-01-01

    In this paper, an intelligence nonlinear control scheme is proposed based on the backstepping method to solve the difficulty of the stable tracking control of the hypersonic morphing vehicle, considering compound disturb⁃ances as well as the influence of model uncertainties and unknown outside disturbances. First, the aerodynamic pa⁃rameters of the morphing vehicle are replaced with a curve⁃fitted approximation in order to build an accurate hyper⁃sonic model. Then, the feedback linearization approach is used to transform the nonlinear vehicle model into a strict feedback multi⁃input/multi⁃output nonlinear system. The nonlinear system is divided into three subsystems accord⁃ing to the features of the state variables and the virtual control signals are calculated for every subsystem. Next, the radial basis function ( RBF) is proved to have excellent capability in restraining unknown disturbances, and a dy⁃namic surface control strategy is employed to eliminate the explosion terms. The simulation results show that the pro⁃posed method can ensure the integral stability of the closed⁃loop system, as well as can have excellent tracing per⁃formance and robustness.%针对可变翼高超声速飞行器的外环稳定跟踪控制问题,考虑可变翼对建模的影响、模型参数不确定和外界未知干扰对跟踪控制性能的影响,提出基于回馈递推的智能非线性控制策略。本文首先利用巡航段气动参数的插值数据建立精确的纵向模型;然后采用输入-输出反馈线性化方法对飞行器纵向模型进行非线性映射,并根据状态变量特性将飞行器划分为三个子系统,利用回馈递推依次求取控制信号,采用RBF神经网络对未知干扰进行逼近,保证鲁棒性能。针对回馈递推设计过程中微分膨胀的问题,加入动态面控制思想进行改进。通过仿真表明,该方法可以保证闭环系统的全局稳定,并且拥有良好的跟踪性能和鲁棒性能。

  18. Heavy ions: Report from Relativistic Heavy Ion Collider

    Indian Academy of Sciences (India)

    Sonia Kabana

    2012-10-01

    We review selected highlights from the experiments at the Relativistic Heavy Ion Collider (RHIC) exploring the QCD phase diagram. A wealth of new results appeared recently from RHIC due to major recent upgrades, like for example the $\\Upsilon$ suppression in central nucleus-nucleus collisions which has been discovered recently in both RHIC and LHC. Furthermore, we discuss RHIC results from the beam energy scan (BES) program aiming to search for a possible critical point and to map out the QCD phase diagram.

  19. Localizing Test Power Consumption for Scan Testing

    Institute of Scientific and Technical Information of China (English)

    XIANG Dong; LI Kai-wei

    2005-01-01

    A two stage scan architecture is proposed to do low powerand low test application cost scan testing. The first stage includes multiple scan chains, where each scan chain is driven by a primary input. Each scan flip-flop in the multiple scan chains drives a group of scan flip-flops. The scan flip-flop in the multiple scan chain and the scan flipflop driven by it are assigned the same values for all test vectors. Scan flip-flops in the multiple scan chains and those in the second stage use separate clock signals, but the design for testability technqiue needs only one clock. The proposed scan architecture localizes test power consumption to the multiple scan chains during test application. Test signals assigned to scan flip-flops in the multiple scan chains are applied to the scan flip-flops in the second stage after the test vector has been applied to the multiple scan chains. This technique can make test power consumption very small.

  20. Developing an Environmental Scanning System.

    Science.gov (United States)

    Morrison, James L.

    A step-by-step approach is provided for developing an environmental scanning system for colleges and universities to assist them in planning for the future. The objectives of such a system are to detect social, scientific, economic, technical, and political interactions important to the organization; define potential threats and opportunities from…

  1. Environmental Scanning, Vancouver Community College.

    Science.gov (United States)

    Yao, Min

    This 1994 environmental scanning report from Vancouver Community College (VCC) reviews the expected effects of the separation of VCC into a new Vancouver Community College and Langara College (LC). The report examines the projected service area student-intake capacity; student characteristics; population growth trends; other postsecondary…

  2. Technical aspects of CT scanning.

    Science.gov (United States)

    Maravilla, K R; Pastel, M S

    1978-01-01

    The advent of computed tomography (CT) has initiated a technological revolution which continues to the present time. A brief review of basic principles of CT scanning is presented, and the evolution of modern CT scanner systems is traced. Some early indications of future trends are also presented.

  3. Broadband antenna with frequency scanning

    Directory of Open Access Journals (Sweden)

    A. A. Shekaturin

    2014-06-01

    Full Text Available Relevance of this study. The main advantage of frequency scanning is simplicity of implementation. At this point, multifunctional usage of microwave modules is an urgent task, as well as their maximum simpler and cheaper. Antenna design and operation. The study is aimed at providing electric antenna with frequency scanning. It was based on the log-periodic antenna due to its wideband and negotiation capability over the entire operating frequency range. For this distribution line is bent in an arc of a circle in a plane blade while vibrators are arranged along the radius. Computer modeling of antennas with frequency scanning. Modeled with a non-mechanical motion antenna beam emitters representing system for receiving a radio frequency signal on mobile objects calculated for 1.8 GHz ... 4.2 GHz. The simulation was performed in a software environment for numerical modeling of electromagnetic «Feko 5.5». Analysis of the interaction of radiation is based on the method of moments. Findings. The result of this work is to propose a new design of the antenna with a frequency scanning method as agreed in a wide frequency range. In the studied technical solution provided by the rotation of NAM in the frequency range, and the matching of the antenna to the feed line is maintained. Application of this type of antennas on the proposed technical solution in communication systems will improve the communication reliability by maintaining coordination in the frequency range

  4. Introduction to scanning tunneling microscopy

    CERN Document Server

    Chen, C Julian

    2008-01-01

    The scanning tunneling and the atomic force microscope, both capable of imaging individual atoms, were crowned with the Physics Nobel Prize in 1986, and are the cornerstones of nanotechnology today. This is a thoroughly updated version of this 'bible' in the field.

  5. Electrochemical metal speciation analysis of chemically heterogeneous samples: the outstanding features of stripping chronopotentiometry at scanned deposition potential

    NARCIS (Netherlands)

    Leeuwen, van H.P.; Town, R.M.

    2003-01-01

    The application of depletive stripping chronopotentiometry at scanned deposition potential (SSCP) to metal ion speciation analysis of chemically heterogeneous complex systems is described. In this electroanalytical stripping technique, metal which is accumulated in the electrode during the depositio

  6. A Plasma Ion Source for ISOLTRAP

    CERN Document Server

    Skov, Thomas Guldager

    2016-01-01

    In this report, my work testing the new Penning ion source as a summer student at ISOLTRAP is described. The project was composed of three stages: (1) Setting up a test laboratory in building 275, (2) characterizing the ion source, and (3) implementing and testing the source in the ISOLTRAP setup. After setting up the test laboratory, the ion source was tested in a constant pressure environment with produced ion currents in the range of nA . An extensive scan of the source ion current versus operating parameters (pressure, voltage) was performed. A setup with pulsed gas flow was also tested, allowing a reduction of the gas load on the vacuum system. The behavior of the ion source together with the ISOLTRAP setup was also investigated, allowing to understand current limitations and future directions of improvement.

  7. Studies on Ion-Exchange Properties of Polyaniline Zr(IV Tungstoiodophosphate Nanocomposite Ion Exchanger

    Directory of Open Access Journals (Sweden)

    K. Jacinth Mispa

    2013-01-01

    Full Text Available Organic-inorganic hybrid materials prepared by sol-gel approach have attracted a great deal of attention in material science. Organic polymeric part of the composite provides mechanical and chemical stability whereas the inorganic part supports the ion-exchange behaviour and thermal stability and also increases the electrical conductivity. Such modified composite materials can be applied as an electrochemically switchable ion exchanger for water treatment, especially water softening. Polyaniline zirconium(IV tungstoiodophosphate nanocomposite ion exchanger is prepared by sol-gel method. Polyaniline zirconium(IV tungstoiodophosphate nanocomposite ion exchanger is synthesized and characterized by Fourier transform-infrared spectra, ultraviolet-visible spectra, X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, ion exchange, conductivity, and antimicrobial studies. A mechanism for the formation of the polyaniline zirconium(IV tungstoiodophosphate nanocomposite ion exchanger was discussed. The route reported here may be used for the preparation of other nanocomposite ion exchangers.

  8. Control on Electron Beam Scanning Track

    Institute of Scientific and Technical Information of China (English)

    王学东; 姚舜

    2004-01-01

    In order to use electron beam as a movable welding heat source and whose energy distribution along its moving trace can be controlled, a method of electron beam scanning track and scanning mode control was put forward. Based on it, the electron beam scanning track and scanning mode can be edited at will according to actual requirements, and the energy input of each point of the scanning track can be controlled. In addition, the scanning frequency and points control, real time adjusting of the scanning track etc. were explained. This method can be used in electron beam brazing, surface modification, surface heat treatment etc.

  9. Children, CT scan and radiation

    Directory of Open Access Journals (Sweden)

    Morteza Bajoghli

    2010-01-01

    Full Text Available Children are more sensitive to radiation than adults. Computer-ized tomography (CT consists of 25 % of all medical imaging. It was estimated that more than 2% of all carcinomas in the USA are due to CT scans. There is an ongoing focus on the reduction of CT scan radiation dose. Awareness about risk-benefits of CT has increased. Reduction of radiological exam is an important issue because the accumulation effects of radiation can be hazardous. In addition, proper protocol should be followed for diagnostic pro-cedures of ionization radiation and computerized tomography. Effective radiation dose should range from 0.8 to 10.5 millisievert. The same protocol should be followed in different hospitals as well. Basic principles of radiation protection should be monitored. As much as possible, both technician and radiologist must be pre-sent during computerized tomography for children, and MRI and ultrasound should be replaced if possible.

  10. /sup 67/Ga lung scan

    Energy Technology Data Exchange (ETDEWEB)

    Niden, A.H.; Mishkin, F.S.; Khurana, M.M.L.; Pick, R.

    1977-03-21

    Twenty-three patients with clinical signs of pulmonary embolic disease and lung infiltrates were studied to determine the value of gallium citrate /sup 67/Ga lung scan in differentiating embolic from inflammatory lung disease. In 11 patients without angiographically proved embolism, only seven had corresponding ventilation-perfusion defects compatible with inflammatory disease. In seven of these 11 patients, the /sup 67/Ga concentration indicated inflammatory disease. In the 12 patients with angiographically proved embolic disease, six had corresponding ventilation-perfusion defects compatible with inflammatory disease. None had an accumulation of /sup 67/Ga in the area of pulmonary infiltrate. Thus, ventilation-perfusion lung scans are of limited value when lung infiltrates are present. In contrast, the accumulation of /sup 67/Ga in the lung indicates an inflammatory process. Gallium imaging can help select those patients with lung infiltrates who need angiography.

  11. Seismic scanning tunneling macroscope - Theory

    KAUST Repository

    Schuster, Gerard T.

    2012-09-01

    We propose a seismic scanning tunneling macroscope (SSTM) that can detect the presence of sub-wavelength scatterers in the near-field of either the source or the receivers. Analytic formulas for the time reverse mirror (TRM) profile associated with a single scatterer model show that the spatial resolution limit to be, unlike the Abbe limit of λ/2, independent of wavelength and linearly proportional to the source-scatterer separation as long as the point scatterer is in the near-field region; if the sub-wavelength scatterer is a spherical impedance discontinuity then the resolution will also be limited by the radius of the sphere. Therefore, superresolution imaging can be achieved as the scatterer approaches the source. This is analogous to an optical scanning tunneling microscope that has sub-wavelength resolution. Scaled to seismic frequencies, it is theoretically possible to extract 100 Hz information from 20 Hz data by imaging of near-field seismic energy.

  12. Differential scanning calorimetry of coal

    Science.gov (United States)

    Gold, P. I.

    1978-01-01

    Differential scanning calorimetry studies performed during the first year of this project demonstrated the occurrence of exothermic reactions associated with the production of volatile matter in or near the plastic region. The temperature and magnitude of the exothermic peak were observed to be strongly affected by the heating rate, sample mass and, to a lesser extent, by sample particle size. Thermal properties also were found to be influenced by oxidation of the coal sample due to weathering effects.

  13. Octreotide scanning for carcinoid tumours.

    OpenAIRE

    Critchley, M

    1997-01-01

    The somatostatin analogue octreotide may be used in the diagnosis of carcinoid and other neuroendocrine tumours. Radionuclide scanning following intravenous injection of 111Indium-labelled octreotide (111In-DTPA-pentetreotide) provides a sensitive, non-invasive method of localising somatostatin-positive tumours. The technique may also be used to identify patients who may respond to 'cold' octreotide therapy and to monitor therapeutic efficacy.

  14. 3D scanning with Kinect

    OpenAIRE

    Novak, David

    2012-01-01

    This paper describes the procedures and technologies used for scanning and three-dimensional reconstruction of objects using the optical scanner Kinect. Theoretical backgrounds of basic computer graphics, projective geometry, optics and graphical reconstruction were studied for better understanding of this field of computer science. A part of the content also describes the structure and operating of the Kinect and is used as a theoretical basis for implementing a new framework for three-di...

  15. New Snail Mail Scanning Service

    CERN Multimedia

    2012-01-01

    Modernisation does not stop at the CERN postal service (GS/PS). “With more and more digitisation and the prevalence of e-mail throughout the site, we were hoping to provide more timely delivery of letters and make further saving in resources”, said Tueri Datta, head of GS/PS.   Instead of the standard delivery to your P.O. box, the CERN postal service will digitally scan all letters and books up to 100 pages on reception. These scans will subsequently be sent via e-mail to the corresponding recipient as PDF (Portable Data Format - you will need to install “Acrobat Reader” on your PC). Express mail will be handled with priority. Users without a valid CERN mailbox can register at mail.scan.service@cern.ch in order to have their letters read to them via the phone line (we are currently investigating whether we can use the voices of the last five DGs).   This service will start on 1st April 2012 on the Meyrin site and will gradually replace th...

  16. Mechanically scanned deployable antenna study

    Science.gov (United States)

    1983-03-01

    The conceptual design of a Mechanically Scanned Deployable Antenna which is launched by the STS (Space Shuttle) to provide radiometric brightness temperature maps of the Earth and oceans at selected frequency bands in the frequency range of 1.4 GHz to 11 GHz is presented. Unlike previous scanning radiometric systems, multiple radiometers for each frequency are required in order to fill in the resolution cells across the swath created by the 15 meter diameter spin stabilized system. This multiple beam radiometric system is sometimes designated as a ""whiskbroom'' system in that it combines the techniques of the scanning and ""pushbroom'' type systems. The definition of the feed system including possible feed elements and location, determination of the fundamental reflector feed offset geometry including offset angles and f/D ratio, preliminary estimates of the beam efficiency of the feed reflector system, a summary of reflector mesh losses at the proposed radiometric frequency bands, an overall conceptual configuration design and preliminary structural and thermal analyses are included.

  17. Probing cytotoxicity of nanoparticles and organic compounds using scanning proton microscopy, scanning electron microscopy and fluorescence microscopy

    Science.gov (United States)

    Tong, Yongpeng; Li, Changming; Liang, Feng; Chen, Jianmin; Zhang, Hong; Liu, Guoqing; Sun, Huibin; Luong, John H. T.

    2008-12-01

    Scanning proton microscopy, scanning electron microscopy (SEM) and fluorescence microscopy have been used to probe the cytotoxicity effect of benzo[a]pyrene (BaP), ethidium bromide (EB) and nanoparticles (ZnO, Al 2O 3 and TiO 2) on a T lymphoblastic leukemia Jurkat cell line. The increased calcium ion (from CaCl 2) in the culture medium stimulated the accumulation of BaP and EB inside the cell, leading to cell death. ZnO, Al 2O 3 and TiO 2 nanoparticles, however, showed a protective effect against these two organic compounds. Such inorganic nanoparticles complexed with BaP or EB which became less toxic to the cell. Fe 2O 3 nanoparticles as an insoluble particle model scavenged by macrophage were investigated in rats. They were scavenged out of the lung tissue about 48 h after infection. This result suggest that some insoluble inorganic nanoparticles of PM (particulate matters) showed protective effects on organic toxins induced acute toxic effects as they can be scavenged by macrophage cells. Whereas, some inorganic ions such as calcium ion in PM may help environmental organic toxins to penetrate cell membrane and induce higher toxic effect.

  18. Probing cytotoxicity of nanoparticles and organic compounds using scanning proton microscopy, scanning electron microscopy and fluorescence microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tong Yongpeng [Institute of Nuclear Techniques, Shenzhen University, Nanhai Avenue 3688, Shenzhen 518060 (China)], E-mail: yongpengt@yahoo.com.cn; Li Changming [School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457 (Singapore); Liang Feng [Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025 (China); Chen Jianmin [Shenzhen Municipal Hospital for Chronic Disease Control and Prevention, Guangdong 518020 (China); Zhang Hong; Liu Guoqing; Sun Huibin [Institute of Nuclear Techniques, Shenzhen University, Nanhai Avenue 3688, Shenzhen 518060 (China); Luong, John H.T. [Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, H4P 2R2 (Canada)

    2008-12-15

    Scanning proton microscopy, scanning electron microscopy (SEM) and fluorescence microscopy have been used to probe the cytotoxicity effect of benzo[a]pyrene (BaP), ethidium bromide (EB) and nanoparticles (ZnO, Al{sub 2}O{sub 3} and TiO{sub 2}) on a T lymphoblastic leukemia Jurkat cell line. The increased calcium ion (from CaCl{sub 2}) in the culture medium stimulated the accumulation of BaP and EB inside the cell, leading to cell death. ZnO, Al{sub 2}O{sub 3} and TiO{sub 2} nanoparticles, however, showed a protective effect against these two organic compounds. Such inorganic nanoparticles complexed with BaP or EB which became less toxic to the cell. Fe{sub 2}O{sub 3} nanoparticles as an insoluble particle model scavenged by macrophage were investigated in rats. They were scavenged out of the lung tissue about 48 h after infection. This result suggest that some insoluble inorganic nanoparticles of PM (particulate matters) showed protective effects on organic toxins induced acute toxic effects as they can be scavenged by macrophage cells. Whereas, some inorganic ions such as calcium ion in PM may help environmental organic toxins to penetrate cell membrane and induce higher toxic effect.

  19. An Adaptive Algorithm to Detect Port Scans

    Institute of Scientific and Technical Information of China (English)

    单蓉胜; 李小勇; 李建华

    2004-01-01

    Detection of port scan is an important component in a network intrusion detection and prevention system. Traditional statistical methods can be easily evaded by stealthy scans and are prone to DeS attacks. This paper presents a new mechanism termed PSD(port scan detection), which is based on TCP packet anomaly evaluation. By learning the port distribution and flags of TCP packets arriving at the protected hosts, PSD can compute the anomaly score of each packet and effectively detect port scans including slow scans and stealthy scans. Experiments show that PSD has high detection accuracy and low detection latency.

  20. Aperture scanning Fourier ptychographic microscopy

    Science.gov (United States)

    Ou, Xiaoze; Chung, Jaebum; Horstmeyer, Roarke; Yang, Changhuei

    2016-01-01

    Fourier ptychographic microscopy (FPM) is implemented through aperture scanning by an LCOS spatial light modulator at the back focal plane of the objective lens. This FPM configuration enables the capturing of the complex scattered field for a 3D sample both in the transmissive mode and the reflective mode. We further show that by combining with the compressive sensing theory, the reconstructed 2D complex scattered field can be used to recover the 3D sample scattering density. This implementation expands the scope of application for FPM and can be beneficial for areas such as tissue imaging and wafer inspection. PMID:27570705

  1. ABS: Sequence alignment by scanning

    KAUST Repository

    Bonny, Mohamed Talal

    2011-08-01

    Sequence alignment is an essential tool in almost any computational biology research. It processes large database sequences and considered to be high consumers of computation time. Heuristic algorithms are used to get approximate but fast results. We introduce fast alignment algorithm, called Alignment By Scanning (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the well-known alignment algorithms, the FASTA (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 76% enhancement in alignment score when it is compared with the FASTA Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  2. The Kv channel blocker 4-aminopyridine enhances Ag+ uptake: A scanning electrochemical microscopy study of single living cells

    OpenAIRE

    Zhan, Dongping; Fan, Fu-Ren F.; Bard, Allen J.

    2008-01-01

    We report that silver ion (Ag+) uptake is enhanced by 4-aminopyridine (4-AP), a well known voltage-sensitive potassium ion channel (Kv) blocker. Both bacterial (Escherichia coli) and mammalian (3T3 fibroblast) cells were used as model systems. Ag+ uptake was monitored with a scanning electrochemical microscope with an amperometric Ag+ ion-selective electrode (Ag+-ISE) and the respiration rates of E. coli cells were measured by oxygen reduction at an ultramicroelectrode. The results showed tha...

  3. Plasma ion sources and ion beam technology in microfabrications

    International Nuclear Information System (INIS)

    For over decades, focused ion beam (FIB) has been playing a very important role in microscale technology and research, among which, semiconductor microfabrication is one of its biggest application area. As the dimensions of IC devices are scaled down, it has shown the need for new ion beam tools and new approaches to the fabrication of small-scale devices. In the meanwhile, nanotechnology has also deeply involved in material science research and bioresearch in recent years. The conventional FIB systems which utilize liquid gallium ion sources to achieve nanometer scale resolution can no longer meet the various requirements raised from such a wide application area such as low contamination, high throughput and so on. The drive towards controlling materials properties at nanometer length scales relies on the availability of efficient tools. In this thesis, three novel ion beam tools have been developed and investigated as the alternatives for the conventional FIB systems in some particular applications. An integrated focused ion beam (FIB) and scanning electron microscope (SEM) system has been developed for direct doping or surface modification. This new instrument employs a mini-RF driven plasma source to generate focused ion beam with various ion species, a FEI two-lens electron (2LE) column for SEM imaging, and a five-axis manipulator system for sample positioning. An all-electrostatic two-lens column has been designed to focus the ion beam extracted from the source. Based on the Munro ion optics simulation, beam spot sizes as small as 100 nm can be achieved at beam energies between 5 to 35 keV if a 5 (micro)m-diameter extraction aperture is used. Smaller beam spot sizes can be obtained with smaller apertures at sacrifice of some beam current. The FEI 2LE column, which utilizes Schottky emission, electrostatic focusing optics, and stacked-disk column construction, can provide high-resolution (as small as 20 nm) imaging capability, with fairly long working distance

  4. Plasma ion sources and ion beam technology inmicrofabrications

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Lili [Univ. of California, Berkeley, CA (United States)

    2007-01-01

    For over decades, focused ion beam (FIB) has been playing a very important role in microscale technology and research, among which, semiconductor microfabrication is one of its biggest application area. As the dimensions of IC devices are scaled down, it has shown the need for new ion beam tools and new approaches to the fabrication of small-scale devices. In the meanwhile, nanotechnology has also deeply involved in material science research and bioresearch in recent years. The conventional FIB systems which utilize liquid gallium ion sources to achieve nanometer scale resolution can no longer meet the various requirements raised from such a wide application area such as low contamination, high throughput and so on. The drive towards controlling materials properties at nanometer length scales relies on the availability of efficient tools. In this thesis, three novel ion beam tools have been developed and investigated as the alternatives for the conventional FIB systems in some particular applications. An integrated focused ion beam (FIB) and scanning electron microscope (SEM) system has been developed for direct doping or surface modification. This new instrument employs a mini-RF driven plasma source to generate focused ion beam with various ion species, a FEI two-lens electron (2LE) column for SEM imaging, and a five-axis manipulator system for sample positioning. An all-electrostatic two-lens column has been designed to focus the ion beam extracted from the source. Based on the Munro ion optics simulation, beam spot sizes as small as 100 nm can be achieved at beam energies between 5 to 35 keV if a 5 μm-diameter extraction aperture is used. Smaller beam spot sizes can be obtained with smaller apertures at sacrifice of some beam current. The FEI 2LE column, which utilizes Schottky emission, electrostatic focusing optics, and stacked-disk column construction, can provide high-resolution (as small as 20 nm) imaging capability, with fairly long working distance (25

  5. Observation of molybdenite surface using scanning Auger microscope

    Science.gov (United States)

    Takagi, S.; Murakami, K.; Gotoh, T.

    1999-04-01

    A preliminary experiment was performed on diffusion of gas particles in the bulk to the surface using the electron stimulated desorption (ESD) method. In molybdenite diffusion of hydrogen from the bulk to the surface was observed by desorbed ion images in the scanning electron microscope. Diffusion to the surface was observed on two types of surface, those with high step density and those with lower density, at about 300 and 400°C of the sample temperatures. The diffusion energy from the bulk to the surface can be larger than the thermal desorption energy at the surface.

  6. Selective Measurement of Calcium and Sodium Ion Conductance Using Sub-Micropipette Probes with Ion Filters

    Science.gov (United States)

    Deng, Xiao Long; Takami, Tomohide; Son, Jong Wan; Kawai, Tomoji; Park, Bae Ho

    2012-02-01

    Selective ion currents in aqueous calcium chloride and sodium chloride solutions with concentrations of up to 1.0 M were observed with sub-micropipettes in which poly(vinyl chloride) (PVC) films containing ionophores selectively filtered cations. Calcium bis[4-(1,1,3,3-tetramethylbutyl)phenyl] phosphate (HDOPP-Ca) and bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate [bis(12-crown-4)] were used as the ionophores to filter calcium and sodium ions, respectively. The selective ion current was observed using a low-current detection system developed from scanning tunneling microscopy. The approximate linear relationship between the ion concentration and ion current suggests that the sub-micropipette probe can be used to detect the intracellular local concentration of a specific ion up to 1.0 M.

  7. Singularity and Bohm criterion in hot positive ion species in the electronegative ion sources

    Science.gov (United States)

    Aslaninejad, Morteza; Yasserian, Kiomars

    2016-05-01

    The structure of the discharge for a magnetized electronegative ion source with two species of positive ions is investigated. The thermal motion of hot positive ions and the singularities involved with it are taken into account. By analytical solution of the neutral region, the location of the singular point and also the values of the plasma parameter such as electric potential and ion density at the singular point are obtained. A generalized Bohm criterion is recovered and discussed. In addition, for the non-neutral solution, the numerical method is used. In contrast with cold ion plasma, qualitative changes are observed. The parameter space region within which oscillations in the density and potential can be observed has been scanned and discussed. The space charge behavior in the vicinity of edge of the ion sources has also been discussed in detail.

  8. ION VATAMANU

    Directory of Open Access Journals (Sweden)

    l. Povar

    2012-12-01

    Full Text Available Ion Vatamanu was a chemist, writer and public figure. He was equally passionate about both his chosen fields of activity: chemistry and poetry. Chemistry, with its perfect equilibrium of logic and precision, provided inspiration for lyrical creativity, whereas poetry writing enlivened his imagination and passion for chemistry. He loved his parents. He adored his wife Elena, whom he often gifted a sea of flowers. He loved his daughters Mihaela, Mariana, and Leontina. He loved life, and he loved people.

  9. Using Environmental Scans in Educational Needs Assessment.

    Science.gov (United States)

    Hatch, Terry F.; Pearson, Thomas G.

    1998-01-01

    Presents advantages and disadvantages of environmental scanning for assessing the context of professional continuing education. Provides a checklist for evaluating the quality and usefulness of information sources. Addresses the ethics of scanning. (SK)

  10. Three-dimensional scanning confocal laser microscope

    Science.gov (United States)

    Anderson, R. Rox; Webb, Robert H.; Rajadhyaksha, Milind

    1999-01-01

    A confocal microscope for generating an image of a sample includes a first scanning element for scanning a light beam along a first axis, and a second scanning element for scanning the light beam at a predetermined amplitude along a second axis perpendicular to the first axis. A third scanning element scans the light beam at a predetermined amplitude along a third axis perpendicular to an imaging plane defined by the first and second axes. The second and third scanning element are synchronized to scan at the same frequency. The second and third predetermined amplitudes are percentages of their maximum amplitudes. A selector determines the second and third predetermined amplitudes such that the sum of the percentages is equal to one-hundred percent.

  11. Electronically-Scanned Fourier-Transform Spectrometer

    Science.gov (United States)

    Breckinridge, J. B.; Ocallaghan, F. G.

    1984-01-01

    Instrument efficient, lightweight, and stable. Fourier-transform spectrometer configuration uses electronic, instead of mechanical, scanning. Configuration insensitive to vibration-induced sampling errors introduced into mechanically scanned systems.

  12. On the role of ion-based imaging methods in modern ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Magallanes, L., E-mail: lorena.magallanes@med.uni-heidelberg.de; Rinaldi, I., E-mail: ilaria.rinaldi@med.uni-heidelberg.de [Heidelberg University Clinic (Dep. Radiation Therapy and Radiation Oncology). Im Neuenheimer Feld 400 69120 Heidelberg, Germany and Ludwig Maximilians University Munich. Am Coulombwall 1, D-85748, Garching (Germany); Brons, S., E-mail: stephan.brons@med.uni-heidelberg.de [Heidelberg Ion Therapy Center. Im Neuenheimer Feld 450 69120 Heidelberg (Germany); Marcelos, T., E-mail: tiago.marcelos@physik.uni-muenchen.de; Parodi, K., E-mail: katia.parodi@physik.uni-muenchen.de [Ludwig Maximilians University Munich. Am Coulombwall 1, D-85748, Garching (Germany); Takechi, M., E-mail: m.takechi@gsi.de [GSI Heimholtz Center for Heavy Ion Research. Planckstraße 1, 64291, Darmstadt (Germany); Voss, B., E-mail: b.voss@gsi.de [GSI Heimholte Center for Heavy Ion Research. Planckstraße 1, 64291, Darmstadt (Germany); Jäkel, O., E-mail: o.jaekel@dkfz-heidelberg.de [Heidelberg University Clinic (Dep. Radiation Therapy and Radiation Oncology). Im Neuenheimer Feld 400 69120 Heidelberg (Germany); Heidelberg Ion Therapy Center. Im Neuenheimer Feld 450 69120 Heidelberg (Germany); German Cancer Research Center, Im N (Germany)

    2014-11-07

    External beam radiotherapy techniques have the common aim to maximize the radiation dose to the target while sparing the surrounding healthy tissues. The inverted and finite depth-dose profile of ion beams (Bragg peak) allows for precise dose delivery and conformai dose distribution. Furthermore, increased radiobiological effectiveness of ions enhances the capability to battle radioresistant tumors. Ion beam therapy requires a precise determination of the ion range, which is particularly sensitive to range uncertainties. Therefore, novel imaging techniques are currently investigated as a tool to improve the quality of ion beam treatments. Approaches already clinically available or under development are based on the detection of secondary particles emitted as a result of nuclear reactions (e.g., positron-annihilation or prompt gammas, charged particles) or transmitted high energy primary ion beams. Transmission imaging techniques make use of the beams exiting the patient, which have higher initial energy and lower fluence than the therapeutic ones. At the Heidelberg Ion Beam Therapy Center, actively scanned energetic proton and carbon ion beams provide an ideal environment for the investigation of ion-based radiography and tomography. This contribution presents the rationale of ion beam therapy, focusing on the role of ion-based transmission imaging methods towards the reduction of range uncertainties and potential improvement of treatment planning.

  13. Hydrolyzed Poly(acrylonitrile) Electrospun Ion-Exchange Fibers

    OpenAIRE

    Jassal, Manisha; Bhowmick, Sankha; Sengupta, Sukalyan; Patra, Prabir K.; Walker, Douglas I.

    2014-01-01

    A potential ion-exchange material was developed from poly(acrylonitrile) fibers that were prepared by electrospinning followed by alkaline hydrolysis (to convert the nitrile group to the carboxylate functional group). Characterization studies performed on this material using X-ray photoelectron spectroscopy, scanning electron microscopy, Fourier-Transform infra-red spectroscopy, and ion chromatography confirmed the presence of ion-exchange functional group (carboxylate). Optimum hydrolysis co...

  14. Ion Beam Extraction by Discrete Ion Focusing

    DEFF Research Database (Denmark)

    2010-01-01

    An apparatus (900) and methods are disclosed for ion beam extraction. In an implementation, the apparatus includes a plasma source (or plasma) (802) and an ion extractor (804). The plasma source is adapted to generate ions and the ion extractor is immersed in the plasma source to extract a fraction...... of the generated ions. The ion extractor is surrounded by a space charge (810) formed at least in part by the extracted ions. The ion extractor includes a biased electrode (806) forming an interface with an insulator (808). The interface is customized to form a strongly curved potential distribution (812......) in the space-charge surrounding the ion extractor. The strongly curved potential distribution focuses the extracted ions towards an opening (814) on a surface of the biased electrode thereby resulting in an ion beam....

  15. Development of heavy-ion irradiation technique for single-event in semiconductor devices

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Norio; Akutsu, Takao; Matsuda, Sumio [National Space Development Agency of Japan, Tsukuba, Ibaraki (Japan). Tsukuba Space Center; Naitoh, Ichiro; Itoh, Hisayoshi; Agematsu, Takashi; Kamiya, Tomihiro; Nashiyama, Isamu

    1997-03-01

    Heavy-ion irradiation technique has been developed for the evaluation of single-event effects on semiconductor devices. For the uniform irradiation of high energy heavy ions to device samples, we have designed and installed a magnetic beam-scanning system in a JAERI cyclotron beam course. It was found that scanned area was approximately 4 x 2 centimeters and that the deviation of ion fluence from the average value was less than 7%. (author)

  16. Issue Scanning: Finding the Future...Maybe.

    Science.gov (United States)

    Plog, Michael; Sweeney, Jim; Weiss, Barry

    Issue Scanning, sometimes called Environmental Scanning, is used in many business, government, educational, and nonprofit organizations. The technique is supposed to monitor the "pulse" of the external environment. The scanning process should lessen the randomness of the information used in decision making, and it should alert managers to trends…

  17. Verification of high efficient broad beam cold cathode ion source.

    Science.gov (United States)

    Abdel Reheem, A M; Ahmed, M M; Abdelhamid, M M; Ashour, A H

    2016-08-01

    An improved form of cold cathode ion source has been designed and constructed. It consists of stainless steel hollow cylinder anode and stainless steel cathode disc, which are separated by a Teflon flange. The electrical discharge and output characteristics have been measured at different pressures using argon, nitrogen, and oxygen gases. The ion exit aperture shape and optimum distance between ion collector plate and cathode disc are studied. The stable discharge current and maximum output ion beam current have been obtained using grid exit aperture. It was found that the optimum distance between ion collector plate and ion exit aperture is equal to 6.25 cm. The cold cathode ion source is used to deposit aluminum coating layer on AZ31 magnesium alloy using argon ion beam current which equals 600 μA. Scanning electron microscope and X-ray diffraction techniques used for characterizing samples before and after aluminum deposition. PMID:27587108

  18. Instrumentation: Ion Chromatography.

    Science.gov (United States)

    Fritz, James S.

    1987-01-01

    Discusses the importance of ion chromatography in separating and measuring anions. The principles of ion exchange are presented, along with some applications of ion chromatography in industry. Ion chromatography systems are described, as well as ion pair and ion exclusion chromatography, column packings, detectors, and programming. (TW)

  19. Influence of scanning force microscope loading force on measurement of ion—track diameter

    Institute of Scientific and Technical Information of China (English)

    WangYu-Gang; AckermannJ; 等

    1997-01-01

    Scanning force microscope(SFM) was operated in the lateral-force mode with different loading forces.The mica samples were irradiated by Se ions with a kinetic energy of 11.4MeV/u.The"full-height width" and the "half-height width" of track profiles were used to evaluate the ion-track diameter,For the former method,the average track diameter increases slowly with increasing loading force between SFM tip and sample.For the later method,the average diameters of ion track nearly keep a common value as the SFM loading force increases.

  20. A fluorescence scanning electron microscope

    Directory of Open Access Journals (Sweden)

    Takaaki Kanemaru

    2010-01-01

    Full Text Available Fluorescence techniques are widely used in biological research to examine molecular localization, while electron microscopy can provide unique ultrastructural information. To date, correlative images from both fluorescence and electron microscopy have been obtained separately using two different instruments, i.e. a fluorescence microscope (FM and an electron microscope (EM. In the current study, a scanning electron microscope (SEM (JEOL JXA8600 M was combined with a fluorescence digital camera microscope unit and this hybrid instrument was named a fluorescence SEM (FL-SEM. In the labeling of FL-SEM samples, both Fluolid, which is an organic EL dye, and Alexa Fluor, were employed. We successfully demonstrated that the FL-SEM is a simple and practical tool for correlative fluorescence and electron microscopy.

  1. QUANTITATIVE CONFOCAL LASER SCANNING MICROSCOPY

    Directory of Open Access Journals (Sweden)

    Merete Krog Raarup

    2011-05-01

    Full Text Available This paper discusses recent advances in confocal laser scanning microscopy (CLSM for imaging of 3D structure as well as quantitative characterization of biomolecular interactions and diffusion behaviour by means of one- and two-photon excitation. The use of CLSM for improved stereological length estimation in thick (up to 0.5 mm tissue is proposed. The techniques of FRET (Fluorescence Resonance Energy Transfer, FLIM (Fluorescence Lifetime Imaging Microscopy, FCS (Fluorescence Correlation Spectroscopy and FRAP (Fluorescence Recovery After Photobleaching are introduced and their applicability for quantitative imaging of biomolecular (co-localization and trafficking in live cells described. The advantage of two-photon versus one-photon excitation in relation to these techniques is discussed.

  2. Scanning ARM Cloud Radar Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Widener, K; Bharadwaj, N; Johnson, K

    2012-06-18

    The scanning ARM cloud radar (SACR) is a polarimetric Doppler radar consisting of three different radar designs based on operating frequency. These are designated as follows: (1) X-band SACR (X-SACR); (2) Ka-band SACR (Ka-SACR); and (3) W-band SACR (W-SACR). There are two SACRs on a single pedestal at each site where SACRs are deployed. The selection of the operating frequencies at each deployed site is predominantly determined by atmospheric attenuation at the site. Because RF attenuation increases with atmospheric water vapor content, ARM's Tropical Western Pacific (TWP) sites use the X-/Ka-band frequency pair. The Southern Great Plains (SGP) and North Slope of Alaska (NSA) sites field the Ka-/W-band frequency pair. One ARM Mobile Facility (AMF1) has a Ka/W-SACR and the other (AMF2) has a X/Ka-SACR.

  3. Scanning strategies for imaging arrays

    CERN Document Server

    Kovács, A

    2008-01-01

    Large-format (sub)millimeter wavelength imaging arrays are best operated in scanning observing modes rather than traditional position-switched (chopped) modes. The choice of observing mode is critical for isolating source signals from various types of noise interference, especially for ground-based instrumentation operating under a bright atmosphere. Ideal observing strategies can combat 1/f noise, resist instrumental defects, sensitively recover emission on large scales, and provide an even field coverage -- all under feasible requirements of telescope movement. This work aims to guide the design of observing patterns that maximize scientific returns. It also compares some of the popular choices of observing modes for (sub)millimeter imaging, such as random, Lissajous, billiard, spiral, On-The-Fly (OTF), DREAM, chopped and stare patterns. Many of the conclusions are also applicable other imaging applications and imaging in one dimension (e.g. spectroscopic observations).

  4. Scanning laser polarimetry in glaucoma

    Directory of Open Access Journals (Sweden)

    Tanuj Dada

    2014-01-01

    Full Text Available Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL. White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells. Hence, the measurement of RNFL thickness has come up. Optical coherence tomography and scanning laser polarimetry (SLP are the techniques that utilize the evaluation of RNFL for the evaluation of glaucoma. SLP provides RNFL thickness measurements based upon the birefringence of the retinal ganglion cell axons. We have reviewed the published literature on the use of SLP in glaucoma. This review elucidates the technological principles, recent developments and the role of SLP in the diagnosis and monitoring of glaucomatous optic neuropathy, in the light of scientific evidence so far.

  5. The utility of bone scans in rheumatology

    International Nuclear Information System (INIS)

    Full text: Introduction: Bone scans are the commonest diagnostic imaging services requested by Australian rheumatologists. Medicare figures suggest that an average rheumatologist orders about $50 000 (AUS) of bone scans annually. Aims: To ascertain the reasons why rheumatologists request bone scans and how it affects their patient management. Methods: A two-part prospective survey was administered before and after every bone scan ordered by four rheumatologists over a six-month period in 1996. Results: A total of 136 bone scans were requested (66.2% whole body; 33.8% regional; 6% SPECT). The primary indications for scanning were (1) to confirm a clinical diagnosis (38%); (2) to exclude a diagnosis (34%); (3) to localize site of pain (17%); and (4) to assist in management (6%). The common diseases that rheumatologists were attempting to confirm/exclude with bone scanning were inflammatory arthritis, malignancy, and fracture. However, the commonest provisional and final diagnosis was soft tissue rheumatism (18%) followed by inflammatory arthritis (15%) and osteoarthritis (11%). In 24% of patients with a provisional diagnosis of soft tissue rheumatism the diagnosis was changed by the bone scan. The scan was successful in excluding a diagnosis in 88 per cent where this was the primary indication for the test. It was successful in confirming a diagnosis in 79 per cent where this was the primary indication. In 32 per cent the bone scan altered the clinical diagnosis and in 43 per cent it altered management. The bone scan result prevented further investigations in 60 per cent. Conclusions: The commonest pre-scan and post-scan diagnosis is soft tissue rheumatism. Rheumatologists predominantly request bone scanning to confirm or exclude their clinical suspicion of inflammatory arthritis, malignancy, and fracture. Bone scans were successful in achieving these objectives in at least 79 per cent of cases

  6. Maskless, resistless ion beam lithography

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Qing

    2003-03-10

    are presented. The formation of shallow pn-junctions in bulk silicon wafers by scanning focused P{sup +} beam implantation at 5 keV is also presented. With implantation dose of around 10{sup 16} cm{sup -2}, the electron concentration is about 2.5 x 10{sup 18} cm{sup -3} and electron mobility is around 200 cm{sup 2}/V{center_dot}s. To demonstrate the suitability of scanning FIB lithography for the manufacture of integrated circuit devices, SOI MOSFET fabrication using the maskless, resistless ion beam lithography is demonstrated. An array of microcolumns can be built by stacking multi-aperture electrode and insulator layers. Because the multicusp plasma source can achieve uniform ion density over a large area, it can be used in conjunction with the array of microcolumns, for massively parallel FIB processing to achieve reasonable exposure throughput.

  7. Maskless, resistless ion beam lithography

    International Nuclear Information System (INIS)

    As the dimensions of semiconductor devices are scaled down, in order to achieve higher levels of integration, optical lithography will no longer be sufficient for the needs of the semiconductor industry. Alternative next-generation lithography (NGL) approaches, such as extreme ultra-violet (EUV), X-ray, electron-beam, and ion projection lithography face some challenging issues with complicated mask technology and low throughput. Among the four major alternative NGL approaches, ion beam lithography is the only one that can provide both maskless and resistless patterning. As such, it can potentially make nano-fabrication much simpler. This thesis investigates a focused ion beam system for maskless, resistless patterning that can be made practical for high-volume production. In order to achieve maskless, resistless patterning, the ion source must be able to produce a variety of ion species. The compact FIB system being developed uses a multicusp plasma ion source, which can generate ion beams of various elements, such as O2+, BF2+, P+ etc., for surface modification and doping applications. With optimized source condition, around 85% of BF2+, over 90% of O2+ and P+ have been achieved. The brightness of the multicusp-plasma ion source is a key issue for its application to maskless ion beam lithography. It can be substantially improved by optimizing the source configuration and extractor geometry. Measured brightness of 2 keV He+ beam is as high as 440 A/cm2 · Sr, which represents a 30x improvement over prior work. Direct patterning of Si thin film using a focused O2+ ion beam has been investigated. A thin surface oxide film can be selectively formed using 3 keV O2+ ions with the dose of 1015 cm-2. The oxide can then serve as a hard mask for patterning of the Si film. The process flow and the experimental results for directly patterned poly-Si features are presented. The formation of shallow pn-junctions in bulk silicon wafers by scanning focused P+ beam implantation at

  8. Handbook of optical and laser scanning

    CERN Document Server

    Marshall, Gerald F

    2011-01-01

    From its initial publication titled Laser Beam Scanning in 1985 to Handbook of Optical and Laser Scanning, now in its second edition, this reference has kept professionals and students at the forefront of optical scanning technology. Carefully and meticulously updated in each iteration, the book continues to be the most comprehensive scanning resource on the market. It examines the breadth and depth of subtopics in the field from a variety of perspectives. The Second Edition covers: Technologies such as piezoelectric devices Applications of laser scanning such as Ladar (laser radar) Underwater

  9. Spatial heterodyne scanning laser confocal holographic microscopy

    CERN Document Server

    Liu, Changgeng

    2016-01-01

    Scanning laser confocal holographic microscopy using a spatial heterodyne detection method is presented. Spatial heterodyne detection technique employs a Mach-Zehnder interferometer with the reference beam frequency shifted by two acousto-optic modulators (AOM) relative to the object beam frequency. Different from the traditional temporal heterodyne detection technique in which hundreds temporal samples are taken at each scanning point to achieve the complex signal, the spatial heterodyne detection technique generates spatial interference fringes by use of a linear tempo-spatial relation provided by galvanometer scanning in a typical line-scanning confocal microscope or for the slow-scanning on one dimension in a point-scanning confocal microscope, thereby significantly reducing sampling rate and increasing the signal to noise ratio under the same illumination compared to the traditional temporal heterodyne counterpart. The proposed spatial heterodyne detection scheme applies to both line-scanning and point-s...

  10. Bone scanning in severe external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Levin, W.J.; Shary, J.H. 3d.; Nichols, L.T.; Lucente, F.E.

    1986-11-01

    Technetium99 Methylene Diphosphate bone scanning has been considered an early valuable tool to diagnose necrotizing progressive malignant external otitis. However, to our knowledge, no formal studies have actually compared bone scans of otherwise young, healthy patients with severe external otitis to scans of patients with clinical presentation of malignant external otitis. Twelve patients with only severe external otitis were studied with Technetium99 Diphosphate and were compared to known cases of malignant otitis. All scans were evaluated by two neuroradiologists with no prior knowledge of the clinical status of the patients. Nine of the 12 patients had positive bone scans with many scans resembling those reported with malignant external otitis. Interestingly, there was no consistent correlation between the severity of clinical presentation and the amount of Technetium uptake. These findings suggest that a positive bone scan alone should not be interpreted as indicative of malignant external otitis.

  11. ION GUN

    Science.gov (United States)

    Dandl, R.A.

    1961-10-24

    An ion gun is described for the production of an electrically neutral ionized plasma. The ion gun comprises an anode and a cathode mounted in concentric relationship with a narrow annulus between. The facing surfaces of the rear portions of the anode and cathode are recessed to form an annular manifold. Positioned within this manifold is an annular intermediate electrode aligned with the an nulus between the anode and cathode. Gas is fed to the manifold and an arc discharge is established between the anode and cathode. The gas is then withdrawn from the manifold through the annulus between the anode and cathode by a pressure differential. The gas is then ionized by the arc discharge across the annulus. The ionized gas is withdrawn from the annulus by the combined effects of the pressure differential and a collimating magnetic field. In a 3000 gauss magnetic field, an arc voltage of 1800 volts, and an arc current of 0.2 amp, a plasma of about 3 x 10/sup 11/ particles/cc is obtained. (AEC)

  12. Scanning Tunneling Optical Resonance Microscopy

    Science.gov (United States)

    Bailey, Sheila; Wilt, Dave; Raffaelle, Ryne; Gennett, Tom; Tin, Padetha; Lau, Janice; Castro, Stephanie; Jenkins, Philip; Scheiman, Dave

    2003-01-01

    Scanning tunneling optical resonance microscopy (STORM) is a method, now undergoing development, for measuring optoelectronic properties of materials and devices on the nanoscale by means of a combination of (1) traditional scanning tunneling microscopy (STM) with (2) tunable laser spectroscopy. In STORM, an STM tip probing a semiconductor is illuminated with modulated light at a wavelength in the visible-to-near-infrared range and the resulting photoenhancement of the tunneling current is measured as a function of the illuminating wavelength. The photoenhancement of tunneling current occurs when the laser photon energy is sufficient to excite charge carriers into the conduction band of the semiconductor. Figure 1 schematically depicts a proposed STORM apparatus. The light for illuminating the semiconductor specimen at the STM would be generated by a ring laser that would be tunable across the wavelength range of interest. The laser beam would be chopped by an achromatic liquid-crystal modulator. A polarization-maintaining optical fiber would couple the light to the tip/sample junction of a commercial STM. An STM can be operated in one of two modes: constant height or constant current. A STORM apparatus would be operated in the constant-current mode, in which the height of the tip relative to the specimen would be varied in order to keep the tunneling current constant. In this mode, a feedback control circuit adjusts the voltage applied to a piezoelectric actuator in the STM that adjusts the height of the STM tip to keep the tunneling current constant. The exponential relationship between the tunneling current and tip-to-sample distance makes it relatively easy to implement this mode of operation. The choice of method by which the photoenhanced portion of the tunneling current would be measured depends on choice of the frequency at which the input illumination would be modulated (chopped). If the frequency of modulation were low enough (typically < 10 Hz) that the

  13. CT scanning: patterns of use and dose

    International Nuclear Information System (INIS)

    CT scanning is a relatively high-dose procedure. In spite of the use of magnetic resonance imaging, with faster CT scanners and helical techniques CT is becoming more common. There are few data from practice in the United States regarding the age and sex distribution of patients receiving CT scans, what type of scan and how many scans they receive, or how much radiation dose CT scans contribute. We reviewed over 33 700 consecutive CT examinations done at our institution in 1998 and 1999. Information on the types of scans as well as the age and sex distribution of the patients was determined. Between 1990 and 1999, CT examinations in our institution increased from 6.1% to 11.1% of all radiology procedures. Nineteen per cent of all patients seen in our department in the last year had at least one CT scan and more than half had multiple scans on the same day. Thirty-six per cent of all patients had a prior CT examination done on an earlier date. The male/female ratio of patients was 56/44. Studies of children age 0-15 years comprised 11.2% of scans. The highest percentage of scans was done in the 36-50-year-old age group. CT scanning accounted for 67% of the effective dose from diagnostic radiology. In most large hospitals in the United States CT scanning probably accounts for more than 10% of diagnostic radiology examinations and about two-thirds of the radiation dose. Most patients have multiple scan sequences. Studies done on children are probably more common than previously thought. (author)

  14. Focused ion beams in biology.

    Science.gov (United States)

    Narayan, Kedar; Subramaniam, Sriram

    2015-11-01

    A quiet revolution is under way in technologies used for nanoscale cellular imaging. Focused ion beams, previously restricted to the materials sciences and semiconductor fields, are rapidly becoming powerful tools for ultrastructural imaging of biological samples. Cell and tissue architecture, as preserved in plastic-embedded resin or in plunge-frozen form, can be investigated in three dimensions by scanning electron microscopy imaging of freshly created surfaces that result from the progressive removal of material using a focused ion beam. The focused ion beam can also be used as a sculpting tool to create specific specimen shapes such as lamellae or needles that can be analyzed further by transmission electron microscopy or by methods that probe chemical composition. Here we provide an in-depth primer to the application of focused ion beams in biology, including a guide to the practical aspects of using the technology, as well as selected examples of its contribution to the generation of new insights into subcellular architecture and mechanisms underlying host-pathogen interactions.

  15. Modulation transfer function of bar code scanning

    Science.gov (United States)

    Tang, Hong; Milster, Tom D.

    1998-09-01

    Bar code scanners are ubiquitous in supermarkets. As a bar code is passed over a scanner, a laser beam scans across the bar code. The scattered light is modulated by the reflectivity of the bars and spaces of the bar code. The bar code scanning process can be described as a 1D convolution of the scanning laser profile and the bar code reflectivity function. The modulation transfer function (MTF) of bar code scanning is the Fourier transform of the marginal profile of the laser beam. The properties of the MTF of bar code scanning is similar to that of an incoherent imaging system. Measurements of the MTF of bar code scanning at one focus position are presented. The experimental results are then discussed.

  16. Clinical applications of Genome Polymorphism Scans

    OpenAIRE

    Weber James L

    2006-01-01

    Abstract Applications of Genome Polymorphism Scans range from the relatively simple such as gender determination and confirmation of biological relationships, to the relatively complex such as determination of autozygosity and propagation of genetic information throughout pedigrees. Unlike nearly all other clinical DNA tests, the Scan is a universal test – it covers all people and all genes. In balance, I argue that the Genome Polymorphism Scan is the most powerful, affordable clinical DNA te...

  17. Scanning Synchronization of Colliding Bunches for MEIC Project

    Energy Technology Data Exchange (ETDEWEB)

    Derbenev, Yaroslav S. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Popov, V. P. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Chernousov, Yu D. [Inst. of Chemical Kinetics and Combustion, Novosibirsk (Russian Federation); Kazakevich, G. M. [Euclid Techlabs LLC., Cleveland, OH (United States)

    2015-09-01

    Synchronization of colliding beams is one of the major issues of an electron-ion collider (EIC) design because of sensitivity of ion revolution frequency to beam energy. A conventional solution for this trouble is insertion of bent chicanes in the arcs space. In our report we consider a method to provide space coincidence of encountering bunches in the crab-crossing orbits Interaction Region (IR) while repetition rates of two beams do not coincide. The method utilizes pair of fast kickers realizing a bypass for the electron bunches as the way to equalize positions of the colliding bunches at the Interaction Point (IP). A dipole-mode warm or SRF cavities fed by the magnetron transmitters are used as fast kickers, allowing a broad-band phase and amplitude control. The proposed scanning synchronization method implies stabilization of luminosity at a maximum via a feedback loop. This synchronization method is evaluated as perspective for the Medium Energy Electron-Ion collider (MEIC) project of JLab with its very high bunch repetition rate.

  18. Parallel scanning probe arrays: their applications

    Directory of Open Access Journals (Sweden)

    Chang Liu

    2008-01-01

    Full Text Available Since the invention of the scanning tunneling microscope (STM1 and the atomic force microscope (AFM2, the field of scanning probe microscopy (SPM instruments has grown steadily and has had a profound influence in materials research, chemistry, biology, nanotechnology, and electronics3,4. Today, scanning probe instruments are used for metrology, characterization5, detection6, manipulation7, patterning8,9, and material modification. A wide range of scanning probe applications are available, taking advantage of various modes of tip–substrate interactions, including force, optics10,11, electrochemistry12, electromagnetics, electrostatics, thermal and mass transfer13,14, and vibration15,16.

  19. Human Digital Modeling & Hand Scanning Lab

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory incorporates specialized scanning equipment, computer workstations and software applications for the acquisition and analysis of digitized models of...

  20. Selected papers on laser scanning and recording

    Science.gov (United States)

    Beiser, L.

    Previously published papers concerned with laser scanning and recording techniques are presented. Subjects treated include laser beam information scanning and recording, laser scanning techniques, system design considerations for laser scanning, laser noise, reliability, resolution, and dynamic range, and optical data storage systems. Consideration is given to the components and media for developing laser scanning and recording systems, in particular the laser, the optics, the scanner, and the storage media. Topics discussed include basic and operational multichannel acoustooptic operation; galvanometer and analog compensations; motor and control systems; angle measurement of scanner by interferometry, preheat-aided laser recording, creating multidimensional scan using a single rotating component, digital techniques in high resolution analog scanning and recording; laser scanning parameters and latitudes in laser xerography; optical video disc technology; focus error detection in optical data storage systems, holographic laser scanners for nonimpact printing; and techniques in optical strobe recording. Laser beam recording, techniques, film recorder systems, laser scanner applicaations, the optimization of printing speed and printout quality of laser beam printers, an internal drum laser scanning plate exposure system, and an ultra-high resolution graphic data terminal are described.

  1. Influence of scanning strategies on the accuracy of digital intraoral scanning systems.

    Science.gov (United States)

    Ender, A; Mehl, A

    2013-01-01

    The digital intraoral impression is a central part in today's CAD/CAM dentistry. With its possibilities, new treatment options for the patient is provided and the prosthetic workflow is accelerated. Nowadays, the major issue with intraoral scanning systems is to gain more accuracy especially for larger scan areas and to simplify clinical handling for the dentist. The aim of this study was to investigate different scanning strategies regardingtheir accuracy with full arch scans in an in-vitro study design. A reference master model was used for the digital impressions with the Lava COS, the Cerec Bluecam and a powderfree intraoral scanning system, Cadent iTero. The trueness and precision of each scanning protocol was measured. Lava COS provides the a trueness of 45.8 microm with the scanning protocol recommended from the manufacturer. A different scanning protocol shows significantly lower accuracy (trueness +/- 90.2 microm). Cerec Bluecam also benefits from an optimal scanning protocol with a trueness of +/- 23.3 microm compared to +/- 52.5 microm with a standard protocol. The powderfree impression system Cadent iTero shows also a high accurate full-arch scan with a trueness of +/- 35.0 microm and a precision of +/- 30.9 microm. With the current intraoral scanning systems, full arch dental impressions are possible with a high accuracy, if adequate scan strategies are used. The powderfree scanning system provides the same level of accuracy compared to scanning systems with surface pretreatment. PMID:23641661

  2. Influence of scanning strategies on the accuracy of digital intraoral scanning systems.

    Science.gov (United States)

    Ender, A; Mehl, A

    2013-01-01

    The digital intraoral impression is a central part in today's CAD/CAM dentistry. With its possibilities, new treatment options for the patient is provided and the prosthetic workflow is accelerated. Nowadays, the major issue with intraoral scanning systems is to gain more accuracy especially for larger scan areas and to simplify clinical handling for the dentist. The aim of this study was to investigate different scanning strategies regardingtheir accuracy with full arch scans in an in-vitro study design. A reference master model was used for the digital impressions with the Lava COS, the Cerec Bluecam and a powderfree intraoral scanning system, Cadent iTero. The trueness and precision of each scanning protocol was measured. Lava COS provides the a trueness of 45.8 microm with the scanning protocol recommended from the manufacturer. A different scanning protocol shows significantly lower accuracy (trueness +/- 90.2 microm). Cerec Bluecam also benefits from an optimal scanning protocol with a trueness of +/- 23.3 microm compared to +/- 52.5 microm with a standard protocol. The powderfree impression system Cadent iTero shows also a high accurate full-arch scan with a trueness of +/- 35.0 microm and a precision of +/- 30.9 microm. With the current intraoral scanning systems, full arch dental impressions are possible with a high accuracy, if adequate scan strategies are used. The powderfree scanning system provides the same level of accuracy compared to scanning systems with surface pretreatment.

  3. Ion funnel ion trap and process

    Science.gov (United States)

    Belov, Mikhail E [Richland, WA; Ibrahim, Yehia M [Richland, WA; Clowers, Biran H [West Richland, WA; Prior, David C [Hermiston, OR; Smith, Richard D [Richland, WA

    2011-02-15

    An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

  4. Simulation of low-energy ion scattering

    Science.gov (United States)

    Langelaar, M. H.; Breeman, M.; Mijiritskii, A. V.; Boerma, D. O.

    A new simulation program `MATCH' has been developed for a detailed analysis of low-energy ion scattering (LEIS) and recoiling data. Instead of performing the full calculation of the three-dimensional trajectories through the sample from the ion source towards the detector, incoming trajectories as well as reversed-time outgoing trajectories are calculated, separately. Finally, these trajectories are matched to obtain the yield. The program has been tested for spectra and azimuthal scans of scattering and recoiling events of various sample species in different scattering geometries.

  5. A model for enterprises’ environmental scanning

    OpenAIRE

    Tudor NISTORESCU; Catalin Mihail BARBU

    2006-01-01

    Today’s environment determines companies to use scanning activities in order to seize the opportunities and to avoid the threats. Individual factors and organizational factors influence the scanning behavior. The examination of the environment can be presented in a model based on environment analyzability and organizational intrusiveness.

  6. Spatial scan statistics using elliptic windows

    DEFF Research Database (Denmark)

    Christiansen, Lasse Engbo; Andersen, Jens Strodl; Wegener, Henrik Caspar;

    The spatial scan statistic is widely used to search for clusters in epidemiologic data. This paper shows that the usually applied elimination of secondary clusters as implemented in SatScan is sensitive to smooth changes in the shape of the clusters. We present an algorithm for generation of set...

  7. Spatial scan statistics using elliptic windows

    DEFF Research Database (Denmark)

    Christiansen, Lasse Engbo; Andersen, Jens Strodl; Wegener, Henrik Caspar;

    2006-01-01

    The spatial scan statistic is widely used to search for clusters. This article shows that the usually applied elimination of secondary clusters as implemented in SatScan is sensitive to smooth changes in the shape of the clusters. We present an algorithm for generation of a set of confocal elliptic...

  8. Security scanning of Web sites at CERN

    CERN Multimedia

    IT Department

    2010-01-01

    As of early 2010, the CERN Computer Security Team will start regular scanning of all Web sites and Web applications at CERN, visible on the Internet, or on the General Purpose Network (office network). The goal of this scanning is to improve the quality of CERN Web sites. All deficits found will be reported by e-mail to the relevant Web site owners, and must be fixed in a timely manner. Web site owners may also request one-off scans of their Web site or Web application, by sending an e-mail to Computer.Security@cern.ch. These Web scans are designed to limit the impact on the scanned Web sites. Nevertheless, in very rare cases scans may cause undesired side-effects, e.g. generate a large number of log entries, or cause particularly badly designed or less robust Web applications to crash. If a Web site is affected by these security scans, it will also be susceptible to any more aggressive scan that can be performed any time by a malicious attacker. Such Web applications should be fixed, and also additionally...

  9. Environmental Scanning Practices for Rural Colleges.

    Science.gov (United States)

    Friedel, Janice Nahra; Lapin, Joel D.

    1995-01-01

    Discusses the importance of environmental scanning in the planning efforts of rural community colleges. Reviews basic techniques and terminology and suggests sources of data. Argues that environmental scanning allows rural colleges to inexpensively forecast change, identify implications for the organization, and plan preferred responses to shape…

  10. Environmental Scanning Is Vital to Strategic Planning.

    Science.gov (United States)

    Poole, Molly Linda

    1991-01-01

    Educators involved in strategic planning can use environmental scanning techniques to anticipate social, economic, political, and technological changes that will affect their schools. Compared to more traditional data gathering, environmental scanning is wider in scope and more concerned with anticipating the future and studying the interaction of…

  11. A Student-Built Scanning Tunneling Microscope

    Science.gov (United States)

    Ekkens, Tom

    2015-01-01

    Many introductory and nanotechnology textbooks discuss the operation of various microscopes including atomic force (AFM), scanning tunneling (STM), and scanning electron microscopes (SEM). In a nanotechnology laboratory class, students frequently utilize microscopes to obtain data without a thought about the detailed operation of the tool itself.…

  12. Scanning electron microscopy - application and techniques

    International Nuclear Information System (INIS)

    The application of the scanning electron microscope, and other image forming scanning systems (STEM and the nuclear microprobe), to a range of nuclear reactor problems is described. Particular attention is given to the solution of fracture problems. Autoradiography, electron spectroscopy, and an investigation of irradiation damage in boron carbide using the transmission electron microscope are also described. (author)

  13. Towards high-speed scanning tunneling microscopy

    NARCIS (Netherlands)

    Tabak, Femke Chantal

    2013-01-01

    In this thesis, two routes towards high-speed scanning tunneling microscopy (STM) are described. The first possibility for high-speed scanning that is discussed is the use of MEMS (Micro-Electro Mechanical Systems) devices as high-speed add-ons in STM microscopes. The functionality of these devices

  14. Live ultrasound volume reconstruction using scout scanning

    Science.gov (United States)

    Meyer, Amelie; Lasso, Andras; Ungi, Tamas; Fichtinger, Gabor

    2015-03-01

    Ultrasound-guided interventions often necessitate scanning of deep-seated anatomical structures that may be hard to visualize. Visualization can be improved using reconstructed 3D ultrasound volumes. High-resolution 3D reconstruction of a large area during clinical interventions is challenging if the region of interest is unknown. We propose a two-stage scanning method allowing the user to perform quick low-resolution scouting followed by high-resolution live volume reconstruction. Scout scanning is accomplished by stacking 2D tracked ultrasound images into a low-resolution volume. Then, within a region of interest defined in the scout scan, live volume reconstruction can be performed by continuous scanning until sufficient image density is achieved. We implemented the workflow as a module of the open-source 3D Slicer application, within the SlicerIGT extension and building on the PLUS toolkit. Scout scanning is performed in a few seconds using 3 mm spacing to allow region of interest definition. Live reconstruction parameters are set to provide good image quality (0.5 mm spacing, hole filling enabled) and feedback is given during live scanning by regularly updated display of the reconstructed volume. Use of scout scanning may allow the physician to identify anatomical structures. Subsequent live volume reconstruction in a region of interest may assist in procedures such as targeting needle interventions or estimating brain shift during surgery.

  15. The white blood cell scan in orthopedics

    Energy Technology Data Exchange (ETDEWEB)

    Propst-Proctor, S.L.; Dillingham, M.F.; McDougall, I.R.; Goodwin, D.

    1982-08-01

    A new nuclear scanning technique was found more specific for bone, joint, and soft tissue infections than any previously described scanning technique. The leukocyte scan, whereby a patient's own cells are labeled with a radioactive tagging agent (/sup 111/In oxine), can distinguish an active infectious process from other pain-inducing conditions. Ninety-seven /sup 111/In labeled autologous leukocyte scans were performed in 88 patients. The findings in 17 of 40 patients scanned for possible acute osteomyelitis, six of nine for suspected septic arthritis, and six for possible soft tissue infections, were positive. Subsequent clinical courses verified the infectious nature of these processes in all patients. Patients who had chronic osteomyelitis (14), bony metastases (four patients), heterotopic ossification (three), and degenerative arthritis (two) demonstrated negative findings. Of the seven patients scanned for acute long-bone fractures, one demonstrated positive findings. Nine scans demonstrated positive findings without determined causes. The leukocyte scan is a useful addition to the diagnostic tools of the orthopedic surgeon.

  16. A Scanning Microwave Radar and Radiometer

    DEFF Research Database (Denmark)

    Skou, Niels

    1995-01-01

    The Scanning Microwave Radar and Radiometer (SMRR) is a line scanner featuring a combined radar and radiometer system operating around 35 and 94 GHz. The layout of the SMRR is shown. The 2 offset antenna parabolas scan in synchronism, the receiver antenna has the highest gain in order to ensure...

  17. Camera Systems Rapidly Scan Large Structures

    Science.gov (United States)

    2013-01-01

    Needing a method to quickly scan large structures like an aircraft wing, Langley Research Center developed the line scanning thermography (LST) system. LST works in tandem with a moving infrared camera to capture how a material responds to changes in temperature. Princeton Junction, New Jersey-based MISTRAS Group Inc. now licenses the technology and uses it in power stations and industrial plants.

  18. Computed tomography scanning during a traumatic resuscitation

    NARCIS (Netherlands)

    L.F.M. Beenen; R. Adams; R.W. Koster; T. Otto

    2011-01-01

    In cardiopulmonary resuscitation, computed tomography (CT) imaging could be of decisive importance to therapeutic strategy making but is yet unavailable because of incompatibility of CT scanning and manual chest compressions. In this report, we describe a case in which CT scanning was performed on a

  19. Optimal stimulation settings for CMAP scan registrations

    NARCIS (Netherlands)

    E.M. Maathuis (Ellen); R.D. Henderson (Robert); J. Drenthen (Judith); N.M. Hutchinson (Nicole); J.R. Daube (Jasper); J.H. Blok (Joleen); G.H. Visser (Gerhard Henk)

    2012-01-01

    textabstractBackground: The CMAP (Compound Muscle Action Potential) scan is a non-invasive electrodiagnostic tool, which provides a quick and visual assessment of motor unit potentials as electrophysiological components that together constitute the CMAP. The CMAP scan records the electrical activity

  20. Pinpoint attack on cancer cell with ions

    International Nuclear Information System (INIS)

    Microbeam technology is indispensable in bio-scientific research, for example the investigation of cell-to-cell communications such as bystander effects, the analysis of cellular spatial sensitivity, the interaction of damage caused by individual irradiation, cellular repair dynamics, and intra-cellular processes such as apoptosis. A single-ion hit technique using the heavy-ion microbeam is being developed at JAEA AVF cyclotron facility for elucidate of biofunctions. A heavy ion microbeam system was developed using a beam collimator with a 5 μm diameter hole. In the new system the microbeam spot was focused to 0.7 μm in diameter using focusing lenses. The PIXE analysis has been widely applied in the fields of biology and medicine. The use of micro-beams allows analyzing trace elements on the cellular level as well. In Air Micro-PIXE images the elemental distribution in the cell by scanning the micro-beams. Biological effects of heavy ion particle beams are markedly more potent, and the dose distribution of heavy ion particle beams is more concentrated than those of X-ray and gamma ray. Therefore, radiotherapy using heavy ion particle beams not only improves the prognosis of cancer patients, but significantly contributes to improvement of their quality of life by conserving the function and morphology of affected organs. A highly precise carbon ion microsurgery system will be developed to treat various small tumours based on the technique of microbeam formation. (author)

  1. Scanning tunneling microscope assembly, reactor, and system

    Science.gov (United States)

    Tao, Feng; Salmeron, Miquel; Somorjai, Gabor A

    2014-11-18

    An embodiment of a scanning tunneling microscope (STM) reactor includes a pressure vessel, an STM assembly, and three spring coupling objects. The pressure vessel includes a sealable port, an interior, and an exterior. An embodiment of an STM system includes a vacuum chamber, an STM reactor, and three springs. The three springs couple the STM reactor to the vacuum chamber and are operable to suspend the scanning tunneling microscope reactor within the interior of the vacuum chamber during operation of the STM reactor. An embodiment of an STM assembly includes a coarse displacement arrangement, a piezoelectric fine displacement scanning tube coupled to the coarse displacement arrangement, and a receiver. The piezoelectric fine displacement scanning tube is coupled to the coarse displacement arrangement. The receiver is coupled to the piezoelectric scanning tube and is operable to receive a tip holder, and the tip holder is operable to receive a tip.

  2. Theory of second optimization for scan experiment

    CERN Document Server

    Mo, X H

    2015-01-01

    The optimal design of scan experiment is of great significance both for scientific research and from economical viewpoint. Two approaches, one has recourse to the sampling technique and the other resorts to the analytical proof, are adopted to figure out the optimized scan scheme for the relevant parameters. The final results indicate that for $n$ parameters scan experiment, $n$ energy points are necessary and sufficient for optimal determination of these $n$ parameters; each optimal position can be acquired by single parameter scan (sampling method), or by analysis of auxiliary function (analytic method); the luminosity allocation among the points can be determined analytically with respect to the relative importance between parameters. By virtue of the second optimization theory established in this paper, it is feasible to accommodate the perfectly optimal scheme for any scan experiment.

  3. MR guided spatial normalization of SPECT scans

    International Nuclear Information System (INIS)

    Full text: In SPECT population studies where magnetic resonance (MR) scans are also available, the higher resolution of the MR scans allows for an improved spatial normalization of the SPECT scans. In this approach, the SPECT images are first coregistered to their corresponding MR images by a linear (affine) transformation which is calculated using SPM's mutual information maximization algorithm. Non-linear spatial normalization maps are then computed either directly from the MR scans using SPM's built in spatial normalization algorithm, or, from segmented TI MR images using DARTEL, an advanced diffeomorphism based spatial normalization algorithm. We compare these MR based methods to standard SPECT based spatial normalization for a population of 27 fibromyalgia patients and 25 healthy controls with spin echo T1 scans. We identify significant perfusion deficits in prefrontal white matter in FM patients, with the DARTEL based spatial normalization procedure yielding stronger statistics than the standard SPECT based spatial normalization. (author)

  4. Theory for broadband detection of ion cyclotron resonance signals

    Science.gov (United States)

    McIver, Robert T.; Ledford, Edward B.; Hunter, Richard L.

    1980-02-01

    A complete line shape theory is developed for the transient response of a new type of ion cyclotron resonance (ICR) detector circuit. The detector is basically a balanced capacitance bridge which is sensitive to the abundance of gaseous ions stored in a static magnetic ion trap. For the first time, the equations of motion of ions in the ICR analyzer cell are shown to be coupled to the circuit equations of the detector. Also, the effect of nonreactive ion-molecule collisions on line shapes and on the transient response of the detector are analyzed and shown to allow measurement of ion-molecule collisions frequencies as a function of ion translational energy. One of the most important features of the capacitance bridge detector is its broadband sensitivity to a wide range of ion cyclotron resonance frequencies. This allows a mass spectrum of ions stored in the ICR analyzer cell to be obtained by scanning the frequency ω1 of the irradiating rf electric field at a fixed magnetic field strength. The capacitance bridge circuit can serve not only as a direct replacement for marginal oscillator circuits traditionally used in ICR experiments, but also as the detector for recently developed Fourier Transform and Rapid Scan ICR experiments.

  5. LHC Report: Ion Age

    CERN Multimedia

    John Jowett for the LHC team

    2013-01-01

    The LHC starts the New Year facing a new challenge: proton-lead collisions in the last month before the shutdown in mid-February.    Commissioning this new and almost unprecedented mode of collider operation is a major challenge both for the LHC and its injector chain. Moreover, it has to be done very quickly to achieve a whole series of physics goals, requiring modifications of the LHC configuration, in a very short time. These include a switch of the beam directions halfway through the run, polarity reversals of the ALICE spectrometer magnet and Van der Meer scans.    The Linac3 team kept the lead source running throughout the end-of-year technical stop, and recovery of the accelerator complex was very quick. New proton and lead beams were soon ready, with a bunch filling pattern that ensures they will eventually match up in the LHC. The LEIR machine has even attained a new ion beam intensity record.  On Friday 11 January the first single bunches o...

  6. Imaging ion and molecular transport at subcellular resolution by secondary ion mass spectrometry

    Science.gov (United States)

    Chandra, Subhash; Morrison, George H.

    1995-05-01

    The transport of K+, Na+, and Ca2+ were imaged in individual cells with a Cameca IMS-3f ion microscope. Strict cryogenic frozen freeze-dry sample preparations were employed. Ion redistribution artifacts in conventional chemical preparations are discussed. Cryogenically prepared freeze-fractured freeze-dried cultured cells allowed the three-dimensional ion microscopic imaging of elements. As smaller structures in calcium images can be resolved with the 0.5 [mu]m spatial resolution, correlative techniques are needed to confirm their identity. The potentials of reflected light microscopy, scanning electron microscopy and laser scanning confocal microscopy are discussed for microfeature recognition in freeze-fractured freeze-dried cells. The feasibility of using frozen freeze-dried cells for imaging molecular transport at subcellular resolution was tested. Ion microscopy successfully imaged the transport of the isotopically tagged (13C, 15N) amino acid, -arginine. The labeled amino acid was imaged at mass 28 with a Cs+ primary ion beam as the 28(13C15N)- species. After a 4 h exposure of LLC-PK1 kidney cells to 4 mM labeled arginine, the amino acid was localized throughout the cell with a preferential incorporation into the nucleus and nucleolus. An example is also shown of the ion microscopic imaging of sodium borocaptate, an experimental therapeutic drug for brain tumors, in cryogenically prepared frozen freeze-dried Swiss 3T3 cells.

  7. Breakdown of the iron passive layer by use of the scanning electrochemical microscope

    Energy Technology Data Exchange (ETDEWEB)

    Still, J.W.; Wipf, D.O. [Mississippi State Univ., MS (United States). Dept. of Chemistry

    1997-08-01

    The scanning electrochemical microscope (SECM) is sued to generate localized corrosion at passivating iron surfaces by using the tip to generate Cl{sup {minus}} ions. Use of the SECM allows the rapid establishment of a locally aggressive chemical environment at a preselected site on the iron surface. The susceptibility for passive layer breakdown and corrosion initiation was examined as a function of the time between the start of the passive layer growth and the formation of Cl{sup {minus}} ions. The breakdown of the passive layer was found to depend strongly on the passivation potential and the site of Cl{sup {minus}} formation on the iron surface. In addition to generating Cl{sup {minus}} ions, the SECM tip was simultaneously used to detect large iron ion concentration fluctuations as corrosion began. Current fluctuations at the tip were observed and ascribed to precursors to the passive layer breakdown.

  8. Ion-optically driven depth compensation for ion beam tracking

    International Nuclear Information System (INIS)

    The beam delivery system for scanned carbon ion beam radiotherapy at GSI has been extended in research mode to irradiate moving targets. For beam tracking, the ion beam is adapted laterally as well as in range corresponding to the target's three dimensional (3D) motion. A beam tracking system with a motorized double wedge system for fast and accurate range adaptation has been developed. In addition to the current range adaptation system a much faster method for online energy modulation is being investigated where a fine focused ion beam is dynamically positioned, controlled by fast dipole magnets, on a small static wedge shaped absorber within the beam line. Experiments were performed at the therapy beam line to study the beam shift from central axis by the first dipole magnet up to the maximum limit where the beam can be deflected back to central axis by the second dipole magnet. Beam profiles were measured at different locations of the beam delivery system. The particle transmission was measured as well at the target position. Experiments were supported by Monte Carlo simulations for energy variation studies and for assessing the influence on beam profiles using MOCADI code

  9. Magnetic field imaging of a tungsten carbide film by scanning nano-SQUID microscope

    Science.gov (United States)

    Shibata, Yusuke; Nomura, Shintaro; Ishiguro, Ryosuke; Kashiwaya, Hiromi; Kashiwaya, Satoshi; Nago, Yusuke; Takayanagi, Hideaki

    2016-10-01

    We present the results of magnetic field imaging by scanning nano-superconducting quantum interference device (SQUID) microscopy on a tungsten carbide (W-C) film fabricated using focused-ion-beam chemical vapor deposition. We have investigated magnetic field change by a W-C film in an external magnetic field using a scanning nano-SQUID microscope system. We have found that the reduction of the magnetic field above the W-C film was 0.9%, indicating the penetration of vortices in the W-C at an external magnetic field of 0.171 mT.

  10. Bone scan in inflammatory osseous disease

    International Nuclear Information System (INIS)

    The /sup 99m/Tc-phosphate bone scan has become a sensitive, reliable, and safe method for evaluating the patient with suspected inflammatory disease of bone. The scan may become positive as early as the first 24 hr after the symptoms and 10-14 days before roentgenographic changes occur. It can be used to differentiate successfully a variety of diseases from osteomyelitis, and in conjunction with 67Ga-citrate scan has become a mainstay in the work-up of the patient with infectious disease. Applications of the bone scan to infectious diseases in pediatric practice are especially helpful, since these diseases are common problems in this age group. Increased experience with the /sup 99m/Tc-phosphate bone scan has already defined several areas of ''limitations'' in evaluating inflammatory disease. ''Cold'' defects, negative scans in early stages of osteomyelitis, and ''extended uptake'' may all pose problems in interpretation, but careful correlation of the bone scan results with clinical history and physical findings, blood cultures, and roentgenography will significantly reduce these problems

  11. Tumor scanning with 57Co-bleomycin

    International Nuclear Information System (INIS)

    The clinical application of 57Co-bleomycin as a tumor scanning radiopharmaceutical was firstly reported by Nouel and Maeda respectively. The authors conducted studies on the diagnostic significance of this tumor scanning agent and presented the results obtained in 40 patients with malignant and non malignant lesions. Six hours and 24 hours after the injection of 500 μCi of 57Co-bleomycin, scintigrams were taken with a 3-inch scintiscanner. Positive scans were found in 20 out of 36 patients with various malignant tumors. Of 20 patients with lung cancer, positive scans were obtained in 17 cases (85%) and of 6 with breast cancer, 3 cases showed positive scans. False negative scans were obtained in another 10 cases of malignant tumors (3 cases of thyroid carcinoma, 4 cases of hepatoma, and 1 case each of gastric carcinoma, peritoneal carcinomatosis, and reticulum cell sarcoma). Of 4 patients with non malignant disease, one case of pulmonary tuberculosis showed a positive scan. In 8 cases of lung cancer and 6 of breast cancer, the relationship between the size of the excised tumor and the scintigram findings was studied. The smallest tumors detected by scintigram were 2 cm in lung cancer and 3.2 cm in breast cancer. (author)

  12. Scanning spreading resistance microscopy of shallow doping profiles in silicon

    Energy Technology Data Exchange (ETDEWEB)

    Suchodolskis, A. [Royal Inst. of Technology, IMIT-MSP, P.O. Box Electrum 229 SE-164 40 Kista (Sweden) and Semiconductor Physics Institute, LT 01108 Vilnius (Lithuania)]. E-mail: suchy@pfi.lt; Hallen, A. [Royal Inst. of Technology, IMIT-MSP, P.O. Box Electrum 229 SE-164 40 Kista (Sweden); Gran, J. [Justervesendet, Fetveien 99, N-2007 Kjeller (Norway); Hansen, T.-E. [AME, P.O. Box 83, N-3191 Horten (Norway); Karlsson, U.O. [Royal Inst. of Technology, IMIT-MSP, P.O. Box Electrum 229 SE-164 40 Kista (Sweden)

    2006-12-15

    We demonstrate the application of scanning spreading resistance microscopy (SSRM) for characterization of shallow highly-conductive layers formed by boron implantation of lowly doped n-type silicon substrate followed by a post-implantation annealing. The electrically active dopant concentration versus depth was obtained from a cross-section of freshly cleaved samples where the Si-surface could be clearly distinguished by depositing a SiO{sub 2}-layer before cleavage. To quantify free carrier concentration we calibrated our data against samples with implanted/annealed boron profiles established by secondary ion mass spectrometry (SIMS). A good fit of SSRM and SIMS data is possible for free carrier concentrations lower than 10{sup 20} cm{sup -3}, but for higher concentrations there is a discrepancy indicating an incomplete activation of the boron.

  13. Ion trap simulation program, ITSIM: A powerful heuristic and predictive tool in ion trap mass spectrometry

    Science.gov (United States)

    Bui, Huy Anh

    The multi-particle simulation program, ITSIM version 4.0, takes advantage of the enhanced performance of the Windows 95 and NT operating systems in areas such as memory management, user friendliness, flexibility of graphics and speed, to investigate the motion of ions in the quadrupole ion trap. The objective of this program is to use computer simulations based on mathematical models to improve the performance of the ion trap mass spectrometer. The simulation program can provide assistance in understanding fundamental aspects of ion trap mass spectrometry, precede and help to direct the course of experiments, as well as having didactic value in elucidating and allowing visualization of ion behavior under different experimental conditions. The program uses the improved Euler method to calculate ion trajectories as numerical solutions to the Mathieu differential equation. This Windows version can simultaneously simulate the trajectories of ions with a virtually unlimited number of different mass-to-charge ratios and hence allows realistic mass spectra, ion kinetic energy distributions and other experimentally measurable properties to be simulated. The large number of simulated ions allows examination of (i) the offsetting effects of mutual ion repulsion and collisional cooling in an ion trap and (ii) the effects of higher order fields. Field inhomogeneities arising from exit holes, electrode misalignment, imperfect electrode surfaces or new trap geometries can be simulated with the program. The simulated data are used to obtain mass spectra from mass-selective instability scans as well as by Fourier transformation of image currents induced by coherently moving ion clouds. Complete instruments, from an ion source through the ion trap mass analyzer to a detector, can now be simulated. Applications of the simulation program are presented and discussed. Comparisons are made between the simulations and experimental data. Fourier transformed experiments and a novel six

  14. Feedback Effects in Combined Fast-Scan Cyclic Voltammetry-Scanning Electrochemical Microscopy

    OpenAIRE

    Schrock, Daniel S.; Wipf, David O.; Baur, John E.

    2007-01-01

    Fast-scan cyclic voltammetry at scan rates between 5 and 1000 Vs−1 was performed at the tip of a scanning electrochemical microscope immersed in a solution of redox mediator. The effect of conducting and insulating substrates on the voltammetric signal was investigated as a function of scan rate and tip-substrate distance. It was found that diffusional interactions between the tip and the substrate are greatest at lower scan rates and on the reverse sweep of the voltammogram. At the fastest s...

  15. Bone scan in diagnosis of infectious osteoarthritis

    International Nuclear Information System (INIS)

    Bone scan with Technetium 99m is harmless method of evaluation of skeletal lesions. It is safe in pediatrics age group and it can be used in early diagnosis of infectious osteoarthritis. Bone scan differentiate osteomyelitis from cellulitis, and also it may help in diagnosis of subclinical involvement of rheumatoid arthritis, benign and malignant bone tumors, stress fractures and periostitis. We report results of bone scan in 30 pediatrics patients as follow: osteomyelitis 9 cases, cellulitis 4 cases, infectious arthritis 7 cases, tuberculous osteoarthritis 2 cases, rheumatoid arthritis 2 cases, and other different diseases 9 cases

  16. Bone scan in diagnosis of infectious osteoarthritis

    International Nuclear Information System (INIS)

    Bone scan with Technetium 99m is harmless method of evaluation of skeletal lesions. It is safe in pediatrics age group and it can be used in early diagnosis of infectious osteo-arthritis. Bone scan differentiate osteomyelitis from cellulitis, and also it may help in diagnosis of subclinical involvement of rheumatoid arthritis, benign and malignant bone tumors, stress fractures and periostitis. We report results of bone scan in 30 pediatric patients as follows: osteomyelitis 9 cases, cellulitis 4 cases, infectious arthritis 4 cases, tuberculous osteoarthritis 2 cases, rheumatoid arthritis 2 cases and other different diseases 9 cases

  17. CT scan for suspected acute appendicitis

    OpenAIRE

    Widlus, David M.

    2012-01-01

    Appendicitis is common with a 7% lifetime risk for an individual in the United States. Mean age at diagnosis is 22 years old. While frequently clinically obvious, by 2006, more than 90% of patients diagnosed with appendicitis had a CT scan of the abdomen and pelvis performed. Use of CT scans has allowed a decrease in false-negative rate at appendectomy to under 10% from a rate of approximately 20% before routine use of CT scan. In addition, the rate of perforation has decreased from nearly 30...

  18. Clinical applications of Genome Polymorphism Scans

    Directory of Open Access Journals (Sweden)

    Weber James L

    2006-06-01

    Full Text Available Abstract Applications of Genome Polymorphism Scans range from the relatively simple such as gender determination and confirmation of biological relationships, to the relatively complex such as determination of autozygosity and propagation of genetic information throughout pedigrees. Unlike nearly all other clinical DNA tests, the Scan is a universal test – it covers all people and all genes. In balance, I argue that the Genome Polymorphism Scan is the most powerful, affordable clinical DNA test available today. Reviewers: This article was reviewed by Scott Weiss (nominated by Neil Smalheiser, Roberta Pagon (nominated by Jerzy Jurka and Val Sheffield (nominated by Neil Smalheiser.

  19. Reconstruction the KROKUS scanning measuring projector

    International Nuclear Information System (INIS)

    Modernized scanning measuring projector, designated for primary scanning of films from bubble chambers is described. Detailed consideration is given to electronic circuit for controlling film-pulling mechanism in three modes: slow pulling, fast pulling and start-stop conditions. Controle unit for scanning device contains the following basic elements: the circuit of controlling by operating elements, photorelay circuit, phase shifting unit and supply unit of projector lamps and electric drive. The maximal image dimension on the screen - 400X600 mm. Film-pulling mechanism enables to load both 35 and 50 mm films

  20. pMSSM scans in ATLAS

    CERN Document Server

    Heinrich, Lukas; The ATLAS collaboration

    2016-01-01

    Multidimensional scans of the pMSSM have been used in ATLAS to assess the experiment sensitivity to classess of models usually not well represented by simplified models. Such scans require a well defined approach in generating signal events and deciding which ones should be passed through the CPU-intensive detector simulation and for which ones the sensitivity can be instead parametrised. They also impose challenges in deciding how the experiment sensitivity should be summarised. The talk will discuss in detail hos such large-scale scans have been approached by ATLAS, touching upon recent results obtained.

  1. Gas phase ion chemistry

    CERN Document Server

    Bowers, Michael T

    1979-01-01

    Gas Phase Ion Chemistry, Volume 1 covers papers on the advances of gas phase ion chemistry. The book discusses the advances in flow tubes and the measurement of ion-molecule rate coefficients and product distributions; the ion chemistry of the earth's atmosphere; and the classical ion-molecule collision theory. The text also describes statistical methods in reaction dynamics; the state selection by photoion-photoelectron coincidence; and the effects of temperature and pressure in the kinetics of ion-molecule reactions. The energy distribution in the unimolecular decomposition of ions, as well

  2. Biological Effects on Fruit Fly by N+ ion Beam Implantation

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Mutation induced by low energy ion beam implantation has beenapplied widely both in plants and microbes. However, due to the vacuum limitation, such ion implantation into animals was never studied except for silkworm. In this study, Pupae of fruit fly were irradiated with different dosage N+ ions at energy 20 KeV to study the biological effect of ion beam on animal. The results showed a saddle-like curve exists between incubate rate and dosage. Damage of pupae by ion beam implantation was observed using scanning electron microscope. Some individuals with incomplete wing were obtained after implantation but no similar character was observed in their offspring. Furthermore, about 5.47% mutants with wide variation appeared in M1 generation. Therefore, ion beam implantation could be widely used for mutation breeding.

  3. Measurements of Beam Ion Loss from the Compact Helical System

    Energy Technology Data Exchange (ETDEWEB)

    D. S. Darrow, M. Isobe, Takashi Kondo, M. Sasao, and the CHS Group National Institute for Fusion Science, Toki, Gifu, Japan

    2010-02-03

    Beam ion loss from the Compact Helical System (CHS) has been measured with a scintillator-type probe. The total loss to the probe, and the pitch angle and gyroradius distributions of that loss, have been measured as various plasma parameters were scanned. Three classes of beam ion loss were observed at the probe position: passing ions with pitch angles within 10o of those of transition orbits, ions on transition orbits, and ions on trapped orbits, typically 15o or more from transition orbits. Some orbit calculations in this geometry have been performed in order to understand the characteristics of the loss. Simulation of the detector signal based upon the following of orbits from realistic beam deposition profiles is not able to reproduce the pitch angle distribution of the losses measured. Consequently it is inferred that internal plasma processes, whether magnetohydrodynamic modes, radial electric fields, or plasma turbulence, move previously confined beam ions to transition orbits, resulting in their loss.

  4. Microfabricated ion frequency standard

    Science.gov (United States)

    Schwindt, Peter; Biedermann, Grant; Blain, Matthew G.; Stick, Daniel L.; Serkland, Darwin K.; Olsson, III, Roy H.

    2010-12-28

    A microfabricated ion frequency standard (i.e. an ion clock) is disclosed with a permanently-sealed vacuum package containing a source of ytterbium (Yb) ions and an octupole ion trap. The source of Yb ions is a micro-hotplate which generates Yb atoms which are then ionized by a ultraviolet light-emitting diode or a field-emission electron source. The octupole ion trap, which confines the Yb ions, is formed from suspended electrodes on a number of stacked-up substrates. A microwave source excites a ground-state transition frequency of the Yb ions, with a frequency-doubled vertical-external-cavity laser (VECSEL) then exciting the Yb ions up to an excited state to produce fluorescent light which is used to tune the microwave source to the ground-state transition frequency, with the microwave source providing a precise frequency output for the ion clock.

  5. Study on Machine Tool Crossbeam Magnetic Levitation System Based on Backstepping Self-adaptive Dynamic Sliding Mode Control%机床横梁悬浮系统的反演自适应动态滑模变结构控制研究

    Institute of Scientific and Technical Information of China (English)

    王通; 迟青光

    2011-01-01

    Disturbance and the system parameters time variation have effects on magnetic levitation system when the tool was cutting. In order to achieve levitation gaps precision control, a backstepping self-adaptive dynamic sliding mode controller was designed at the moving crossbeam levitation system of the gantry NC machining center. Using this method, chatting of the system could be effectively decreased and the stability of levitation system could be kept. Due to the introduction of self-adaptive control strategy, the control ability restraining parameters uncertainty was greatly improved. The simulated result shows that this controller has powerful anti-disturbance ability and makes the system has high rigidity. It can achieve steady levitation.%在龙门数控加工中心移动横梁磁悬浮系统中,刀具切削工件过程中磁悬浮系统所受到扰动和系统自身参数的时变性对悬浮高度有影响.为了实现悬浮高度的精确控制,设计了控制悬浮高度的反演自适应动态滑模控制器,该控制器可有效削弱系统抖振并保持悬浮高度的稳定性;引入自适应控制策略,大大改进了滑模控制对不确定性系统参数的控制能力.仿真结果表明:该控制器具有很强的抗扰性,并使系统具有较高刚度,实现了稳定悬浮.

  6. Successive Resonances for Ion Ejection at Arbitrary Frequencies in an Ion Trap

    Science.gov (United States)

    Snyder, Dalton T.; Cooks, R. Graham

    2016-09-01

    The use of successive resonances for ion ejection is demonstrated here as a method of scanning quadrupole ion traps with improvement in both resolution and sensitivity compared with single frequency resonance ejection. The conventional single frequency resonance ejection waveform is replaced with a dual-frequency waveform. The two included frequencies are spaced very closely and their relative amplitudes are adjusted so that the first frequency that ions encounter excites them to higher amplitudes where space charge effects are less prominent, thereby giving faster and more efficient ejection when the ions come into resonance with the second frequency. The method is applicable at any arbitrary frequency, unlike double and triple resonance methods. However, like double and triple resonance ejection, ejection using successive resonances requires the rf and AC waveforms to be phase-locked in order to retain mass accuracy and mass precision. The improved performance is seen in mass spectra acquired by rf amplitude scans (resonance ejection) as well as by secular frequency scans.

  7. CHARACTERIZATION OF PRECIPITATES IN CUBIC SILICON CARBIDE IMPLANTED WITH 25Mg+ IONS

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Weilin; Spurgeon, Steven R.; Liu, Jia; Edwards, Danny J.; Schreiber, Daniel K.; Henager, Charles H.; Kurtz, Richard J.; Wang, Yongqiang

    2016-09-26

    The aim of this study is to characterize precipitates in Mg+ ion implanted and high-temperature annealed cubic silicon carbide using scanning transmission electron microscopy, electron energy loss spectroscopy and atom probe tomography.

  8. Ion Coulomb Crystals

    CERN Document Server

    Thompson, Richard C

    2014-01-01

    Ion Coulomb crystals (ICC), formed by atomic ions at low temperatures in radiofrequency and Penning ion traps, are structures that have remarkable properties and many applications. Images of Coulomb crystals are striking and reveal the crystal structure, which arises from a balance between the trapping forces acting on the ions and their mutual Coulomb repulsion. Applications of these structures range from frequency standards and quantum simulation through to measurement of the cross sections of chemical reactions of ions.

  9. Electron Beam Scanning in Industrial Applications

    Science.gov (United States)

    Jongen, Yves; Herer, Arnold

    1996-05-01

    Scanned electron beams are used within many industries for applications such as sterilization of medical disposables, crosslinking of wire and cables insulating jackets, polymerization and degradation of resins and biomaterials, modification of semiconductors, coloration of gemstones and glasses, removal of oxides from coal plant flue gasses, and the curing of advanced composites and other molded forms. X-rays generated from scanned electron beams make yet other applications, such as food irradiation, viable. Typical accelerators for these applications range in beam energy from 0.5MeV to 10 MeV, with beam powers between 5 to 500kW and scanning widths between 20 and 300 cm. Since precise control of dose delivery is required in many of these applications, the integration of beam characteristics, product conveyance, and beam scanning mechanisms must be well understood and optimized. Fundamental issues and some case examples are presented.

  10. Indium-111 leukocyte scanning and fracture healing

    International Nuclear Information System (INIS)

    This study was undertaken to determine the specificity of indium-111 leukocyte scans for osteomyelitis when fractures are present. Midshaft tibial osteotomies were performed in 14 New Zealand white rabbits, seven of which were infected postoperatively with Staphylococcus aureus per Norden's protocol. All 14 rabbits were scanned following injection with 75 microCi of indium 111 at 72 h after osteotomy and at weekly intervals for 4 weeks. Before the rabbits were killed, the fracture sites were cultured to document the presence or absence of infection. The results of all infected osteotomy sites were positive, whereas no positive scans were found in the noninfected osteotomies. We concluded from this study that uncomplicated fracture healing does not result in a positive indium-111 leukocyte scan

  11. A Scanning Quantum Cryogenic Atom Microscope

    CERN Document Server

    Yang, Fan; Taylor, Stephen F; Turner, Richard W; Lev, Benjamin L

    2016-01-01

    Microscopic imaging of local magnetic fields provides a window into the organizing principles of complex and technologically relevant condensed matter materials. However, a wide variety of intriguing strongly correlated and topologically nontrivial materials exhibit poorly understood phenomena outside the detection capability of state-of-the-art high-sensitivity, high-resolution scanning probe magnetometers. We introduce a quantum-noise-limited scanning probe magnetometer that can operate from room-to-cryogenic temperatures with unprecedented DC-field sensitivity and micron-scale resolution. The Scanning Quantum Cryogenic Atom Microscope (SQCRAMscope) employs a magnetically levitated atomic Bose-Einstein condensate (BEC), thereby providing immunity to conductive and blackbody radiative heating. The SQCRAMscope has a noise floor of 300 pT and provides a 100x improvement in magnetic flux sensitivity over previous atomic scanning probe magnetometers. These capabilities are carefully benchmarked by imaging magnet...

  12. Probe microscopy: Scanning below the cell surface

    Science.gov (United States)

    Sahin, Ozgur

    2008-08-01

    Conventional atomic force microscopy probes only the surface of specimens. A related technique called scanning near-field ultrasonic holography can now image nanoparticles buried below the surfaces of cells, which could prove useful in nanotoxicology.

  13. Noncontact dimensional measurement system using holographic scanning

    Science.gov (United States)

    Sagan, Stephen F.; Rosso, Robert S.; Rowe, David M.

    1997-07-01

    Holographic scanning systems have been used for years in point-of-sale bar code scanners and other low resolution applications. These simple scanning systems could not successfully provide the accuracy and precision required to measure, inspect and control the production of today's high tech optical fibers, medical extrusions and electrical cables. A new class of instruments for the precision measurement of industrial processes has been created by the development of systems with a unique combination of holographic optical elements that can compensate for the wavelength drift in laser diodes, the application of proprietary post-processing algorithms, and the advancements in replication methods to fabricate low cost holographic scanning discs. These systems have improved upon the performance of traditional polygon mirror scanners. This paper presents the optical configuration and design features that have been incorporated into a holographic scanning inspection system that provides higher productivity, increased product quality and lower production costs for many manufacturers.

  14. EO Scanned Micro-LADAR Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR program we will develop, design and build new scanning based micro-ladar sensors with unprecedented small size, weight, and power (SWaP), thereby...

  15. Intelligent Classification and Visualization of Network Scans

    Energy Technology Data Exchange (ETDEWEB)

    Chen, L; Muelder, C; Ma, K; Bartoletti, A

    2007-03-01

    Network scans are a common first step in a network intrusion attempt. In order to gain information about a potential network intrusion, it is beneficial to analyze these network scans. Statistical methods such as wavelet scalogram analysis have been used along with visualization techniques in previous methods. However, applying these statistical methods to reduce the data causes a substantial amount of data loss. This paper presents a study of using associative memory learning techniques to directly compare network scans in order to create a classification which can be used by itself or in conjunction with existing visualization techniques to better characterize the sources of these scans. This produces an integrated system of visual and intelligent analysis which is applicable to real world data.

  16. EO Scanned Micro-LADAR Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this phase II SBIR we will design, build, test, and deliver new scanning based micro-ladar sensors with unprecedented small size, weight, and power (SWaP),...

  17. Nanoscale thermometry by scanning thermal microscopy

    Science.gov (United States)

    Menges, Fabian; Riel, Heike; Stemmer, Andreas; Gotsmann, Bernd

    2016-07-01

    Measuring temperature is a central challenge in nanoscience and technology. Addressing this challenge, we report the development of a high-vacuum scanning thermal microscope and a method for non-equilibrium scanning probe thermometry. The microscope is built inside an electromagnetically shielded, temperature-stabilized laboratory and features nanoscopic spatial resolution at sub-nanoWatt heat flux sensitivity. The method is a dual signal-sensing technique inferring temperature by probing a total steady-state heat flux simultaneously to a temporally modulated heat flux signal between a self-heated scanning probe sensor and a sample. Contact-related artifacts, which so far limit the reliability of nanoscopic temperature measurements by scanning thermal microscopy, are minimized. We characterize the microscope's performance and demonstrate the benefits of the new thermometry approach by studying hot spots near lithographically defined constrictions in a self-heated metal interconnect.

  18. Photodetachment of cold OH- in a multipole ion trap

    OpenAIRE

    Trippel, S.; Mikosch, J.; Berhane, R.; Otto, R; Weidemüller, M.; Wester, R.

    2006-01-01

    The absolute photodetachment cross section of OH- anions at a rotational and translational temperature of 170K is determined by measuring the detachment-induced decay rate of the anions in a multipole radio-frequency ion trap. In comparison with previous results, the obtained cross section shows the importance of the initial rotational state distribution. Using a tomography scan of the photodetachment laser through the trapped ion cloud, the derived cross section is model-independent and thus...

  19. The external scanning proton microprobe of Firenze: A comprehensive description

    Science.gov (United States)

    Giuntini, L.; Massi, M.; Calusi, S.

    2007-06-01

    An external proton scanning microbeam setup is installed on the -30° line of the new 3 MV tandem accelerator in Firenze; the most relevant features of the line, such as detection setup for IBA measurements, target viewing system, beam diagnostic and transport are described here. With our facility we can work with a beam spot on sample better than 10 μm full-width half-maximum (FWHM) and an intensity of some nanoamperes. Standard beam exit windows are silicon nitride (Si 3N 4) TEM membranes, 100 nm thick and 0.5×0.5 mm 2 wide; we also successfully performed measurements using membranes 1×1 mm 2 wide, 100 nm thick, and 2×2 mm 2 wide, 200 and 500 nm thick. Exploiting the yield of Si X-rays produced by the beam in the exit window as an indirect measurement of the charge, a beam charge monitor system was implemented. The analytical capabilities of the microbeam have been extended by integrating a two-detector PIXE setup with BS and PIGE detectors; the external scanning proton microprobe in Firenze is thus a powerful instrument to fully characterize samples by ion beam analysis, through the simultaneous collection of PIXE, PIGE and BS elemental maps. Its characteristics can make it often competitive with traditional in vacuum microbeam for measurements of thick targets.

  20. Scan matching SLAM in underwater environments

    OpenAIRE

    Mallios, Angelos; Ridao Rodríguez, Pere; Ribas Romagós, David; Hernàndez Bes, Emili

    2014-01-01

    This paper proposes a pose-based algorithm to solve the full simultaneous localization and mapping problem for autonomous underwater vehicle (AUV) navigating in unknown and possibly unstructured environments. The proposed method first estimates the local path traveled by the robot while forming the acoustic image (scan) with range data coming from a mono-beam rotating sonar head, providing position estimates for correcting the distortions that the vehicle motion produces in the scans. Then, c...

  1. Towards high-speed scanning tunneling microscopy

    OpenAIRE

    Tabak, Femke Chantal

    2013-01-01

    In this thesis, two routes towards high-speed scanning tunneling microscopy (STM) are described. The first possibility for high-speed scanning that is discussed is the use of MEMS (Micro-Electro Mechanical Systems) devices as high-speed add-ons in STM microscopes. The functionality of these devices is shown using finite-element simulations, combined with measurements of their resonance frequency and actuation range. Tip deposition was done using EBID (Electron-Beam Induced Deposition) which a...

  2. Scanning probe microscopy on new dental alloys

    Science.gov (United States)

    Reusch, B.; Geis-Gerstorfer, J.; Ziegler, C.

    Surface analytical methods such as scanning force microscopy (SFM), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were used to determine the surface properties of amalgam substitutes as tooth filling materials. In particular the corrosion and the passivation behavior of new gallium restorative materials were studied. To give relevant practical data, the measurements were performed with and without the alloys being stored in artificial saliva to simulate physiological oral conditions.

  3. Optimal stimulation settings for CMAP scan registrations

    OpenAIRE

    Maathuis Ellen M; Henderson Robert D; Drenthen Judith; Hutchinson Nicole M; Daube Jasper R; Blok Joleen H; Visser Gerhard H

    2012-01-01

    Abstract Background The CMAP (Compound Muscle Action Potential) scan is a non-invasive electrodiagnostic tool, which provides a quick and visual assessment of motor unit potentials as electrophysiological components that together constitute the CMAP. The CMAP scan records the electrical activity of the muscle (CMAP) in response to transcutaneous stimulation of the motor nerve with gradual changes in stimulus intensity. Large MUs, including those that result from collateral reinnervation, appe...

  4. Analysis of the volatile compounds in Senecio scandens Buch-Ham by gas chromatography-tandem mass spectrometry based on diversified scan technologies.

    Science.gov (United States)

    Li, Sensen; Su, Yue; Guo, Yinlong

    2011-01-01

    Static headspace gas chromatography-tandem mass spectrometry was used to identify volatile compounds from Senecio scandens Buch-Ham. The elemental composition of compounds was confirmed by exploiting the tandem mass spectra of isotopic peaks from the precursor ion. Some isomers were well distinguished by the diversified scan technologies of tandem mass spectrometry (MS/MS). The MS/MS included a product ion scan, a precursor ion scan and a neutral loss scan. The results showed that 46 volatile compounds were completely identified, and the great of majority compounds were α-pinene (11.93%), n-caproaldehyde (9.02%) and dehydrosabinene (6.22%). This qualitative method is convenient and accurate and can be considered as a complementary identification method for the qualitative analysis of volatile compounds in complex samples. PMID:22006636

  5. Graphene engineering by neon ion beams.

    Science.gov (United States)

    Iberi, Vighter; Ievlev, Anton V; Vlassiouk, Ivan; Jesse, Stephen; Kalinin, Sergei V; Joy, David C; Rondinone, Adam J; Belianinov, Alex; Ovchinnikova, Olga S

    2016-03-29

    Achieving the ultimate limits of lithographic resolution and material performance necessitates engineering of matter with atomic, molecular, and mesoscale fidelity. With the advent of scanning helium ion microscopy, maskless He(+) and Ne(+) beam lithography of 2D materials, such as graphene-based nanoelectronics, is coming to the forefront as a tool for fabrication and surface manipulation. However, the effects of using a Ne focused-ion-beam on the fidelity of structures created out of 2D materials have yet to be explored. Here, we will discuss the use of energetic Ne ions in engineering graphene nanostructures and explore their mechanical, electromechanical and chemical properties using scanning probe microscopy (SPM). By using SPM-based techniques such as band excitation (BE) force modulation microscopy, Kelvin probe force microscopy (KPFM) and Raman spectroscopy, we are able to ascertain changes in the mechanical, electrical and optical properties of Ne(+) beam milled graphene nanostructures and surrounding regions. Additionally, we are able to link localized defects around the milled graphene to ion milling parameters such as dwell time and number of beam passes in order to characterize the induced changes in mechanical and electromechanical properties of the graphene surface.

  6. Graphene engineering by neon ion beams

    Science.gov (United States)

    Iberi, Vighter; Ievlev, Anton V.; Vlassiouk, Ivan; Jesse, Stephen; Kalinin, Sergei V.; Joy, David C.; Rondinone, Adam J.; Belianinov, Alex; Ovchinnikova, Olga S.

    2016-03-01

    Achieving the ultimate limits of lithographic resolution and material performance necessitates engineering of matter with atomic, molecular, and mesoscale fidelity. With the advent of scanning helium ion microscopy, maskless He+ and Ne+ beam lithography of 2D materials, such as graphene-based nanoelectronics, is coming to the forefront as a tool for fabrication and surface manipulation. However, the effects of using a Ne focused-ion-beam on the fidelity of structures created out of 2D materials have yet to be explored. Here, we will discuss the use of energetic Ne ions in engineering graphene nanostructures and explore their mechanical, electromechanical and chemical properties using scanning probe microscopy (SPM). By using SPM-based techniques such as band excitation (BE) force modulation microscopy, Kelvin probe force microscopy (KPFM) and Raman spectroscopy, we are able to ascertain changes in the mechanical, electrical and optical properties of Ne+ beam milled graphene nanostructures and surrounding regions. Additionally, we are able to link localized defects around the milled graphene to ion milling parameters such as dwell time and number of beam passes in order to characterize the induced changes in mechanical and electromechanical properties of the graphene surface.

  7. Role of bone scan in rheumatic disease

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Young [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2003-06-01

    Rheumatic diseases can be categorized by pathology into several specific types of musculoskeletal problems, including synovitis (e.g. rheumatoid arthritis), enthesopathy (e.g. ankylosing spondylitis) and cartilage degeneration (e.g. osteoarthritis). Skeletal radiographs have contributed to the diagnosis of these articular diseases, and some disease entities need typical radiographic changes as a factor of the diagnostic criteria. However, they sometimes show normal radiographic findings in the early stage of disease, when there is demineralization of less than 30-50%. Bone scans have also been used in arthritis, but not widely because the findings are nonspecific and it is thought that bone scans do not add significant information to routine radiography. Bone scans do however play a different role than simple radiography, and it is a complementary imaging method in the course of management of arthritis. The image quality of bone scans can be improved by obtaining regional views and images under al pin-hole collimator, and through a variety of scintigraphic techniques including the three phase bone scan and bone SPECT. Therefore, bone scans could improve the diagnostic value, and answer multiple clinical questions, based on the pathophysiology of various forms of arthritis.

  8. MEMS-based fast scanning probe microscopes

    International Nuclear Information System (INIS)

    Scanning probe microscopy is a frequently used nanometer-scale surface investigation technique. Unfortunately, its applicability is limited by the relatively low image acquisition speed, typically seconds to minutes per image. Higher imaging speeds are desirable for rapid inspection of samples and for the study of a range of dynamic surface processes, such as catalysis and crystal growth. We have designed a new high-speed scanning probe microscope (SPM) based on micro-electro mechanical systems (MEMS). MEMS are small, typically micrometer size devices that can be designed to perform the scanning motion required in an SPM system. These devices can be optimized to have high resonance frequencies (up to the MHz range) and have very low mass (10-11 kg). Therefore, MEMS can perform fast scanning motion without exciting resonances in the mechanical loop of the SPM, and hence scan the surface without causing the image distortion from which conventional piezo scanners suffer. We have designed a MEMS z-scanner which we have integrated in commercial AFM (atomic force microscope) and STM (scanning tunneling microscope) setups. We show the first successful AFM experiments.

  9. Continuous scanning of the mobility and size distribution of charged clusters and nanometer particles in atmospheric air and the Balanced Scanning Mobility Analyzer BSMA

    Science.gov (United States)

    Tammet, H.

    2006-12-01

    Measuring of charged nanometer particles in atmospheric air is a routine task in research on atmospheric electricity, where these particles are called the atmospheric ions. An aspiration condenser is the most popular instrument for measuring atmospheric ions. Continuous scanning of a mobility distribution is possible when the aspiration condenser is connected as an arm of a balanced bridge. Transfer function of an aspiration condenser is calculated according to the measurements of geometric dimensions, air flow rate, driving voltage, and electric current. The most complicated phase of the calibration is the estimation of the inlet loss of ions due to the Brownian deposition. The available models of ion deposition on the protective inlet screen and the inlet control electrofilter have the uncertainty of about 20%. To keep the uncertainty of measurements low the adsorption should not exceed a few tens of percent. The online conversion of the mobility distribution to the size distribution and a correct reduction of inlet losses are possible when air temperature and pressure are measured simultaneously with the mobility distribution. Two instruments called the Balanced Scanning Mobility Analyzers (BSMA) were manufactured and tested in routine atmospheric measurements. The concentration of atmospheric ions of the size of about a few nanometers is very low and a high air flow rate is required to collect enough of ion current. The air flow of 52 l/s exceeds the air flow in usual aerosol instruments by 2-3 orders of magnitude. The high flow rate reduces the time of ion passage to 60 ms and the heating of air in an analyzer to 0.2 K, which suppresses a possible transformation of ions inside the instrument. The mobility range of the BSMA of 0.032-3.2 cm 2 V - 1 s - 1 is logarithmically uniformly divided into 16 fractions. The size distribution is presented by 12 fractions in the diameter range of 0.4-7.5 nm. The measurement noise of a fraction concentration is typically

  10. Feedback effects in combined fast-scan cyclic voltammetry-scanning electrochemical microscopy.

    Science.gov (United States)

    Schrock, Daniel S; Wipf, David O; Baur, John E

    2007-07-01

    Fast-scan cyclic voltammetry at scan rates between 5 and 1000 V s(-1) was performed at the tip of a scanning electrochemical microscope immersed in a solution of redox mediator. The effect of conducting and insulating substrates on the voltammetric signal was investigated as a function of scan rate and tip-substrate distance. It was found that diffusional interactions between the tip and the substrate are greatest at lower scan rates and on the reverse sweep of the voltammogram. At the fastest scan rates used, the tip could be brought to with 1 microm of the substrate without appreciable perturbation of the voltammogram. By selecting scan rates and tip-substrate distances such that feedback effects were negligible, it was possible to image the diffusion layer of a 10 microm Pt substrate electrode. With the tip placed 1 microm above a biological cell, tip-substrate diffusional interactions were greatly diminished at a scan rate of 100 V s(-1) and absent at a scan rate of 1000 V s(-1). These results suggest conditions can be selected that allow chemical imaging of substrates without the feedback interactions typically encountered in scanning electrochemical microscopy. PMID:17550230

  11. Solid-state electrochemistry on the nanometer and atomic scales: the scanning probe microscopy approach

    Science.gov (United States)

    Strelcov, Evgheni; Yang, Sang Mo; Jesse, Stephen; Balke, Nina; Vasudevan, Rama K.; Kalinin, Sergei V.

    2016-07-01

    Energy technologies of the 21st century require an understanding and precise control over ion transport and electrochemistry at all length scales - from single atoms to macroscopic devices. This short review provides a summary of recent studies dedicated to methods of advanced scanning probe microscopy for probing electrochemical transformations in solids at the meso-, nano- and atomic scales. The discussion presents the advantages and limitations of several techniques and a wealth of examples highlighting peculiarities of nanoscale electrochemistry.

  12. Application of pressure scanning to the tuning of a high resolution dye laser

    International Nuclear Information System (INIS)

    Pressure tuning of a dye laser pumped by a nitrogen laser is described. Tuning is by a grating with an intracavity etalon or by grating, etalon and extracavity confocal filter. Pressure chambers of dry nitrogen surround the grating filter combination and the filter, respectively. Without the filter, the tuning range is more than 40 cm-1. With the filter the scan range is 4 cm-1. Results of an absorption experiment show isotope shifts of the chromium ions in ruby. (U.S.)

  13. FRS ion catcher: Ion survival efficiency of radioactive ions

    International Nuclear Information System (INIS)

    At the MATS and LaSpec experiments of the LEB of the Super-FRS, high precision experiments will be done with low-energy exotic nuclei. To reach out to the most exotic nuclei, high efficiencies in the thermalization and beam preparation (e.g., separation and identification) are of upmost importance. Therefore, these parameters are optimized and tested online with the of the FRS Ion Catcher facility and in a separate off-line experiment. An in depth study of ion survival efficiencies has been performed to characterize the cryogenic stopping cell, to understand the slowing down process and to optimize the overall efficiency of the FRS Ion Catcher. Alpha-decay recoil ions from a 223Ra source are used to determine the ion survival and transport efficiencies, which reflect the charge-exchange and stripping cross-sections during the slowing down process of the ions. These investigations as well as other efficiency optimizations of the FRS Ion Catcher are presented.

  14. Ions and light

    CERN Document Server

    Bowers, Michael T

    2013-01-01

    Gas Phase Ion Chemistry, Volume 3: Ions and Light discusses how ions are formed by electron impact, ion-molecule reactions, or electrical discharge. This book discusses the use of light emitted by excited molecules to characterize either the chemistry that formed the excited ion, the structure of the excited ion, or both.Organized into 10 chapters, this volume begins with an overview of the extension of the classical flowing afterglow technique to include infrared and chemiluminescence and laser-induced fluorescence detection. This text then examines the experiments involving molecules that ar

  15. Scan path entropy and Arrow plots: Capturing scanning behavior of multiple observers

    Directory of Open Access Journals (Sweden)

    Ignace T C Hooge

    2013-12-01

    Full Text Available Designers of visual communication material want their material to attract and retain attention. In marketing research, heat maps, dwell time, and time to AOI first hit are often used as evaluation parameters. Here we present two additional measures 1 scan path entropy to quantify gaze guidance and 2 the arrow plot to visualize the average scan path. Both are based on string representations of scan paths. The latter also incorporates transition matrices and time required for 50% of the observers to first hit AOIs (T50. The new measures were tested in an eye tracking study (48 observers, 39 advertisements. Scan path entropy is a sensible measure for gaze guidance and the new visualization method reveals aspects of the average scan path and gives a better indication in what order global scanning takes place.

  16. Scan path entropy and arrow plots: capturing scanning behavior of multiple observers.

    Science.gov (United States)

    Hooge, Ignace; Camps, Guido

    2013-01-01

    Designers of visual communication material want their material to attract and retain attention. In marketing research, heat maps, dwell time, and time to AOI first hit are often used as evaluation parameters. Here we present two additional measures (1) "scan path entropy" to quantify gaze guidance and (2) the "arrow plot" to visualize the average scan path. Both are based on string representations of scan paths. The latter also incorporates transition matrices and time required for 50% of the observers to first hit AOIs (T50). The new measures were tested in an eye tracking study (48 observers, 39 advertisements). Scan path entropy is a sensible measure for gaze guidance and the new visualization method reveals aspects of the average scan path and gives a better indication in what order global scanning takes place. PMID:24399993

  17. Modified Cr valence in symmetric oxygen ion conducting half cells with ion flow

    Science.gov (United States)

    Finsterbusch, Martin; Lussier, Alexandre; Negusse, Ezana; Idzerda, Yves

    2010-03-01

    The degradation mechanisms in ion conducting materials, including solid oxide fuel cells (SOFC), are still of high interest in current energy research, especially with regards to material and interface stability, fuel impurities and impurities originating from sealing or interconnect materials. A common practice is the use of symmetric half-cells (e.g. cathode/electrolyte/cathode) to determine interface stability via cross section Energy Dispersive x-ray Spectroscopy line scans and overpotential magnitude and degradation via AC-impedance spectroscopy. Using these electrically driven half-cells, we have developed a new method to directly measure degradation due to oxygen ion flow through ion conducting materials and their associated interface structures. By using X-ray absorption spectroscopy of cells before and after oxygen ion flow (800 C for 100 hours), we determined that the valence state of Cr that migrated from a metallic interconnect into the porous cathode changes in valence from +3 (Cr2O3) to +6 (CrO3), depending on the direction of the oxygen ion flow. This observation is strong evidence of the influence of the oxygen ion flux on the degradation mechanisms of ion conducting materials.

  18. Bone scans in nasopharyngeal carcinoma: local experience

    International Nuclear Information System (INIS)

    Introduction: Nasopharyngeal carcinoma (NPC) tops the list of malignancy in Malaysia and ranks first in male malignancy in the state of Sarawak. The majority of the NPC patients presented in the advanced stages and often with distal metastasis usually to the bones. In our local hospital is the new practice of bone scan using Tc99 started last year. Over a period of 9 months from July 2003 to March 2004, 41 NPC patients had the bone scans and our experience in these are reviewed and presented. Method: The NPC patients are selected consecutively including both new and treated patients. The scanner used is Siemen E.cam plus and Technecium (Tc99) the radio-active isotope used. The scan images are read and reported by qualified and trained Radiologists. The bone scans are requested from the ENT Specialist of the ENT department of the Hospital. The bone scan reports are checked by the ENT Specialists and the decisions made as to clinical correlation and further definitive imaging studies. Results: 41 NPC patients were included in the studies, 29 newly diagnosed and bone-canned before treatment started and 12 treated of which 3 being diagnosed having recurrent NPC. Of the 29 newly diagnosed patients, one was found true positive bone scan having increased radio-tracer uptake and confirmed Xray imagings. 3 of the treated patients had true positive bone scan with increased radio-tracer uptake and confirmed Xray imagings. Hence a total of 4 out of the 41 patients (9.8%) had bone metastasis on positive bone scans. Of the 29 newly diagnosed patients, 14 were found false positive bone scan having increased radio-tracer uptake but no confirmed X ray imagings. 4 of the treated patients had false positive bone scan with increased radio-tracer uptake but no confirmed X ray imagings. Hence a total of 18 out of the 41 patients (44%) had no bone metastasis on positive bone scans. There were 6 patients with symptoms referable to the bones' distal to the head and 2 had true positive bone

  19. Pose-based SLAM with probabilistic scan matching algorithm using a mechanical scanned imaging sonar

    OpenAIRE

    Mallios, Angelos; Ridao Rodríguez, Pere; Hernàndez Bes, Emili; Ribas Romagós, David; Maurelli, Francesco; Petillot, Yvan R.

    2009-01-01

    This paper proposes a pose-based algorithm to solve the full SLAM problem for an autonomous underwater vehicle (AUV), navigating in an unknown and possibly unstructured environment. The technique incorporate probabilistic scan matching with range scans gathered from a mechanical scanning imaging sonar (MSIS) and the robot dead-reckoning displacements estimated from a Doppler velocity log (DVL) and a motion reference unit (MRU). The proposed method utilizes two extended Kalman filters (EKF). T...

  20. Pose-based slam with probabilistic scan matching algorithm using a mechanical scanned imaging sonar

    OpenAIRE

    Mallios, Angelos; Ridao, Pere; Hernández, Emili; Ribas, David

    2010-01-01

    This paper proposes a pose-based algorithm to solve the full SLAM problem for an Autonomous Underwater Vehicle (AUV), navigating in an unknown and possibly unstructured environment. The technique incorporate probabilistic scan matching with range scans gathered from a Mechanical Scanned Imaging Sonar (MSIS) and the robot dead-reckoning displacements estimated from a Doppler Velocity Log (DVL) and a Motion Reference Unit (MRU). The raw data from the sensors are processed and ...