Sample records for background current state

  1. Current state and future prospects of remedial soil protection. Background

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, Joerg


    The legal basis for soil protection in the Federal Republic of Germany is: -The Act on Protection against Harmful Changes to Soil and on Rehabilitation of Contaminated Sites (Federal Soil Protection Act) (Bundes-Bodenschutzgesetz - BBodSchG) of 1998 [1] -The Federal Soil Protection and Contaminated Sites Ordinance (BBodSchV) of 1999 [2]. In Germany, the Federal Government has legislative competence in the field of soil protection. The Lander (German federal states), in turn, are responsible for enforcement of the BBodSchG and the BBodSchV; they may also issue supplementary procedural regulations. According to Article 1 BBodschG, the purpose of the Act is inter alia to protect and restore the functions of the soil on a permanent sustainable basis. These actions shall include prevention of harmful soil changes as well as rehabilitating soil, contaminated sites and waters contaminated by such sites in such a way that any contamination remains permanently below the hazard threshold. Whilst prevention aims to protect and preserve soil functions on a long-term basis, the object of remediation is mainly to avert concrete hazards in a spatial, temporal and manageable causative context. ''Remedial soil protection'' encompasses a tiered procedure in which a suspicion is verified successively and with least-possible effort and in which the circumstances of the individual case at hand are taken into account in deciding whether or not a need for remediation exists. It comprises the systematic stages of identifying, investigating and assessing suspect sites and sites suspected of being contaminated with a view to their hazard potential, determining whether remediation is necessary, remediating identified harmful soil changes and contaminated sites, and carrying out, where necessary, aftercare measures following final inspection of the remedial measure. (orig.)

  2. Teaching in Multicultural Background in the States

    Institute of Scientific and Technical Information of China (English)



    The diversity present in every aspect of American life is an inevitable consequence of its multicultural society.Schools across the country are a reflection of what is,and always has been,an ever changing demographic constitution.Classroom teachers,especially teachers who have no teaching experience in the country,face a stiff challenge of teaching all students,regardless of their backgrounds.As a Chinese guest teacher in the States,I learned that the"growing-up"of a teacher requires positive changes in three areas:knowledge,attitudes and skills.Support from administrators is also vital in the"growing-up"process.

  3. Energetics of internal solitary waves in a background sheared current

    Directory of Open Access Journals (Sweden)

    K. G. Lamb


    Full Text Available The energetics of internal waves in the presence of a background sheared current is explored via numerical simulations for four different situations based on oceanographic conditions: the nonlinear interaction of two internal solitary waves; an internal solitary wave shoaling through a turning point; internal solitary wave reflection from a sloping boundary and a deep-water internal seiche trapped in a deep basin. In the simulations with variable water depth using the Boussinesq approximation the combination of a background sheared current, bathymetry and a rigid lid results in a change in the total energy of the system due to the work done by a pressure change that is established across the domain. A final simulation of the deep-water internal seiche in which the Boussinesq approximation is not invoked and a diffuse air-water interface is added to the system results in the energy remaining constant because the generation of surface waves prevents the establishment of a net pressure increase across the domain. The difference in the perturbation energy in the Boussinesq and non-Boussinesq simulations is accounted for by the surface waves.

  4. Ultrarelativistic electron states in a general background electromagnetic field

    CERN Document Server

    Di Piazza, A


    The feasibility of obtaining analytical results in the realm of QED in the presence of a background electromagnetic field is almost exclusively limited to a few tractable cases, where the Dirac equation can be solved exactly in the corresponding background field. This circumstance has restricted, in particular, the theoretical analysis of QED processes in intense laser fields to within the plane-wave approximation even at those high intensities, achievable experimentally only by tightly focusing the laser energy in space. Here, we construct analytically quasiclassical one-particle electron states in the presence of a background electromagnetic field of general space-time structure in the realistic assumption that the initial energy of the electron is the largest scale in the problem. The relatively compact expression of these states opens, in particular, the possibility of investigating analytically strong-field QED processes in the presence of spatially focused laser beams, which is of particular relevance i...

  5. Social Pedagogy in North America: historical background and current developments

    Directory of Open Access Journals (Sweden)

    Daniel Schugurensky


    Full Text Available In North America, the use of the term ‘social pedagogy’ is a relatively new phenomenon, but social pedagogical practices have been used for a long time. The recent interest in the field of social pedagogy can be explained in part by the publication of an unprecedented volume of books and articles in English language, the creation of a new international journal, the simultaneous development of graduate programs in social pedagogy in the UK and the USA, and the establishment of a social pedagogy association that brings together academics and practitioners. In North America, social pedagogy thinking is influenced by the history of the field, by current social pedagogy theory and practice in other parts of the world, and by several traditions that connect education with social change. The paper discusses ten of them: indigenous education, progressive education, social movement learning, community development, public pedagogy, popular education, participatory action research, social economy, participatory democracy, and critical theory. 

  6. The Cosmic Microwave Background State of the Art

    CERN Document Server

    Barreiro, R B


    We review the current status of the cosmic microwave background (CMB) radiation, including a revision of some basic theoretical aspects, a summary of anisotropy detections and CMB experiments, and a description of some relevant characteristics of the microwave foregrounds. We also discuss the different estimators proposed in the literature to detect non-Gaussianity and outline the basis of some reconstruction methods that have been applied to the CMB.

  7. Effect of background parabolic current on characteristics and energetics of internal solitary waves by numerical simulation

    Institute of Scientific and Technical Information of China (English)

    L Haibin; XIE Jieshuo; YAO Yuan; XU Jiexin; CHEN Zhiwu; HE Yinghui; CAI Shuqun


    Based on modifications of the observed background parabolic current in upper layer of the northeastern South China Sea (SCS), the effects of eight kinds of background currents on the characteristics and energy conversion of internal solitary waves (ISWs) are investigated by an Internal Gravity Wave (IGW) model. It is found that, although the background current has little effect on the number of the generated ISWs, it reduces the resulted phase speed of ISW. When the background parabolic current appears with its lower boundary near or above the main thermocline, the ISW amplitude and the depth of the isopycnal undergoing maximum displacement increase;when the background parabolic current curvature is reduced, the ISW amplitude and the ratio of baroclinic to barotropic energy reduce, whilst the phase speed of ISW, the baroclinic energy, and the ratio of baroclinic kinetic energy (KE) to available potential energy (APE) increase; when the lower boundary of background parabolic current extends down to the seabed and the background current curvature is reduced, the ISW amplitude and phase speed decrease, whilst the barotropic kinetic energy, the baroclinic energy and the ratio of KE to APE increase. At a whole depth, when the lower background current curvature is reduced and the upper current curvature is increased, the ISW amplitude, and phase speed, the ratio of baroclinic to barotropic energy, the baroclinic energy, and the ratio of KE to APE all increase.

  8. State regulation and power plant productivity: background and recommendations

    Energy Technology Data Exchange (ETDEWEB)


    This report was prepared by representatives of several state regulatory agencies. It is a guide to some of the activities currently under way in state agencies to promote increased availability of electrical generating power plants. Standard measures of plant performance are defined and the nature of data bases that report such measures is discussed. It includes reviews of current state, federal, and industry programs to enhance power plant productivity and provides detailed outlines of programs in effect in California, Illinois, Michigan, New York, North Carolina, Ohio, and Texas. A number of actions are presented that could be adopted by state regulatory agencies, depending on local conditions. They include: develop a commission position or policy statement to encourage productivity improvements by utilities; coordinate state efforts with ongoing industry and government programs to improve the acquisition of power plant performance data and the maintenance of quality information systems; acquire the capability to perform independent analyses of power plant productivity; direct the establishment of productivity improvement programs, including explicit performance objectives for both existing and planned power plants, and a performance program; establish a program of incentives to motivate productivity improvement activities; and participate in ongoing efforts at all levels and initiate new actions to promote productivity improvements.

  9. Current state of food radiopreservation

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, P.; Kyzlink, V. (Vysoka Skola Chemicko-Technologicka, Prague (Czechoslovakia)); Rusz, J. (Vyzkumny Ustav Masneho Prumyslu, Brno (Czechoslovakia))


    Irradiation of foodstuffs causes undesirable changes in oxylabile vitamins and lipids, the release of smelly products or the softening of fibres even at very low doses. A combination of irradiation with heating or freezing is used in the attempt to mitigate these unfavourable effects. Gamma and x rays are used for irradiation, beta rays are being tried which inactivate microorganisms on the surface of the foodstuff and interfere only very little with the internal structure of the foodstuff. In case dose rates over 1 kGy are used it will be necessary to test the toxicity and mutagenicity of the irradiated foodstuff on laboratory animals. Next to undesirable changes in the sensory properties and nutritional value of the foodstuffs there are also the high costs of irradiation which amount to 5 to 10% of the price of the foodstuff. Currently, irradiation is permitted for the preservation of foodstuffs in 21 countries of the world.

  10. Rosacea: current state of epidemiology. (United States)

    Tan, Jerry; Berg, Mats


    Case definitions are critical in epidemiologic research. However, modern disease indicators must now consider complex data from gene-based research along with traditional clinical parameters. Rosacea is a skin disorder with multiple signs and symptoms. In individuals, these features may be multiple or one may predominate. While studies on the epidemiology of rosacea have previously been sparse, there has been a recent increase in research activity. A broader body of epidemiological information that includes a greater variety of countries beyond Northern Europe and general population-based demographics is needed. As there are operational issues in current case definitions of rosacea subtypes--rationalization and standardization--universal consistent applications in future research is also imperative. Further improvement in disease definition combining new research information along with clinical pragmatism should increase the accuracy of rosacea case ascertainment and facilitate further epidemiological research.

  11. Solid state recording current meter conversion (United States)

    Cheng, Ralph T.; Wang, Lichen


    The authors describe the conversion of an Endeco-174 current meter to a solid-state recording current meter. A removable solid-state module was designed to fit in the space originally occupied by an 8-track tape cartridge. The module contains a CPU and 128 kilobytes of nonvolatile CMOS memory. The solid-state module communicates with any terminal or computer using an RS-232C interface at 4800 baud rate. A primary consideration for conversion was to keep modifications of the current meter to a minimum. The communication protocol was designed to emulate the Endeco tape translation unit, thus the need for a translation unit was eliminated and the original data reduction programs can be used without any modification. After conversion, the data recording section of the current meter contains no moving parts; the storage capacity of the module is equivalent to that of the original tape cartridge.

  12. Background current affects the internal wave structure of the northern South China Sea

    Institute of Scientific and Technical Information of China (English)

    Shuqun Cai; Xiaomin Long; Danpeng Dong; Shengan Wang


    The internal wave modal equations are solved with the consideration of background currents.Analytical and numerical solutions of some specific examples,including observations in the northern South China Sea(SCS),are obtained to investigate the effect of background current on internal wave vertical structure.The effects of current shear and curvature on intemal wave vertical structure are evaluated separately.It is found that the phase speed and wave structure are modified by background currents,the current shear has little effect on wave structure.whilst the current curvature Could have a strong impact on the wave structure.The extent of the effect by the current curvature on the wave structure depends on the magnitudes of current curvature,relative wave speed,and buoyancy frequency,sometimes the effect by the current curvature may even cause the wave to attenuate severely with depth.A new method to obtain the real eigenfunction with depth in the case that the waves become evanescent is also put forward.It is shown that the residual tidal current in the northern SCS is strong enough to cause the wave to attenuate severely at the upper layer.


    Directory of Open Access Journals (Sweden)

    Orlov A. I.


    Full Text Available The concept of risk-controlling is based on the general theory of risk. The current state of risk-management in our country is reviewed. We also discuss the research on risk-controlling made in the BMSTU Laboratory of economic-mathematical methods in controlling

  14. Flat Currents of Green-Schwarz Superstring in AdS2 × S2 Background

    Institute of Scientific and Technical Information of China (English)


    From the κ symmetric action of ⅡB string in AdS2 × S2 background given by Zhou, we derive the equations of motion. By using the twisted dual transformation which was introduced by Hou, we construct the flat currents, conserving non-local charge with one free parameter, for the superstring in AdS2 × S2.

  15. The charged current neutrino cross section for solar neutrinos, and background to \\BBz\\ experiments

    CERN Document Server

    Ejiri, H


    Solar neutrinos can interact with the source isotope in neutrinoless double beta decay experiments through charged current and neutral current interactions. The charged-current product nucleus will then beta decay with a Q-value larger than the double beta decay Q-value. As a result, this process can populate the region of interest and be a background to the double beta decay signal. In this paper we estimate the solar neutrino capture rates on three commonly used double beta decay isotopes, \

  16. Low Background Counting with the Berkeley Low Background Facility and the Black Hills State University Underground Campus at SURF (United States)

    Poon, Alan; Thomas, Keenan; Mount, Brianna; Lesko, Kevin; Smith, Alan; Norman, Eric; Chan, Yuen-Dat; Berkeley Low Background Facility Team; Black Hills State University Underground Campus Team


    The Berkeley Low Background Facility provides a variety of low background gamma spectroscopy services to a variety of projects and experiments. It operates HPGe spectrometers in two unique facilities: a surface low background lab at LBNL and 4,850 feet underground (4300 m.w.e.) at the Sanford Underground Research Facility in Lead, SD in a dedicated cleanroom at the Black Hills State University Underground Campus (BHUC). A large component of the measurements performed by the BLBF are for ultralow background experiments concerned with U, Th, K, and other radioisotopes within candidate construction materials to be used to construct sensitive detectors. Experiments utilizing these needs often include those studying dark matter, neutrinos, or neutrinoless double beta decay. A general overview of the services and facilities will be presented. The BHUC will ultimately host several HPGe low background counting stations and other sensitive instruments from several incoming low background groups and projects that will operate in a coordinated manner to provide low background measurements to the scientific community. An overview and description of the BHUC facility, status, and future plans will also be discussed.



    Shull, Bernard


    The Gramm-Leach-Bliley Financial Modernization Act went into effect in the United States in1999. The Act establishes a new framework for affiliations among commercial banks, insurance companies and securities firms through "financial holding companies" and "financial subsidiaries", and establishes guidelines for entry into merchant banking. It moves financial institutions in the United States towards a system of conglomeration that has long existed in continental Europe and elsewhere in the w...

  18. Canada ocean energy atlas phase 1 : potential tidal current energy resources analysis background

    Energy Technology Data Exchange (ETDEWEB)

    Tarbotton, M.; Larson, M. [Triton Consultants Ltd., Vancouver, BC (Canada)


    This report was prepared as a background document for a preliminary tidal current resource inventory for Canadian waters. Energy calculations in the study were based on preliminary estimates of known tidal flows. The inventory was based on nautical charts, Canadian sailing directions, tide and tidal current constituent data, and numerical tidal modelling data. A finite element harmonic tidal model tool was used to provide tidal height and current velocities data for a varying number of tidal constituents. The study identified several major tidal current power resources throughout Canada. It was concluded that modelling studies should concentrate on Minas Basin in Nova Scotia; Georgia and Johnstone Straits in British Columbia; and Hudson's Strait and Ungava Bay. Modelling studies should provide estimates of extractable energy as well as provide initial assessments of the environmental impacts of tidal energy extraction in all 3 regions. 3 refs., 8 tabs., 16 figs.

  19. [Current state of competence assessment in nursing]. (United States)

    Darmann-Finck, Ingrid; Reuschenbach, Bernd


    Competency measurement is central to the optimisation of outcome oriented educational processes in nursing, similar to the concept of evidence based practice. The classification of measurement tools provides the basis for describing the current state of research and development in relation to competence measurement in nursing science, and any gaps are identified. The article concludes with questioning the importance of outcome oriented quality orientation in order to achieve an increase in quality during training. Further methodological developments and qualitative studies are needed to examine the context specific processes of interaction and learning, beyond competence diagnostics.


    Directory of Open Access Journals (Sweden)

    Гузель Рефкадовна Фаизова


    Full Text Available The role and importance of the retail banking business in the banking sector continueto grow. The current state of the retail banking business is considered and specific features of this area in the face of growing demand for banking products and services by the public and interest from lending institutions are identified by the article.Purpose: Research of current state of retail banking business and detection specific features of this area.Methodology: In the process of analysis and researchof the question the methods of economical and statistical analysis, methods of comparison and generalizationwereused.Results: The conclusion is that interest in the retail banking business continues to grow.There were revealed the role and the importance of standardized service processes and standardized products and services delivering as one of the main line of development in the segment of retail business.DOI:

  1. Trilingual aligned corpus – current state and new applications

    Directory of Open Access Journals (Sweden)

    Ludmila Dimitrova


    Full Text Available Trilingual aligned corpus – current state and new applications This article describes current state of a trilingual parallel corpus consisted of texts in two Slavic (Bulgarian and Polish and one Baltic language (Lithuanian. The corpus contains original literary texts (fiction, novels, and short stories in one of the three languages with translations to the other two, and texts in other languages translated into Bulgarian, Polish, and Lithuanian. A part of the texts are aligned at the sentence level. The authors propose a semantic annotation of verbs appearing in these aligned texts that will facilitate contrastive studies of natural languages. A theoretical background for the proposed semantic annotation is briefly also discussed.

  2. Current helicity and electromotive force of magnetoconvection influenced by helical background fields

    CERN Document Server

    Ruediger, Guenther


    Motivated by the empirical finding that the known hemispheric rules for the current helicity at the solar surface are not strict, the excitation of small-scale current helicity by the influence of a large-scale helical magnetic background fields on nonrotating magnetoconvection is demonstrated. It is shown within a quasilinear analytic theory of driven turbulence and by nonlinear simulations of magnetoconvection that the resulting small-scale current helicity has the same sign as the large-scale current helicity while the ratio of both pseudo-scalars is of the order of the magnetic Reynolds number of the convection. The same models do not provide finite values of the small-scale kinetic helicity. On the other hand, a turbulence-induced electromotive force is produced including the diamagnetic pumping term as well as the eddy diffusivity but no alpha effect. It is thus argued that the relations by Pouquet & Patterson (1978) and Keinigs (1983) for the simultaneous existence of small-scale current helicity a...

  3. Characterization and influence of cardiac background sodium current in the atrioventricular node. (United States)

    Cheng, Hongwei; Li, Jue; James, Andrew F; Inada, Shin; Choisy, Stéphanie C M; Orchard, Clive H; Zhang, Henggui; Boyett, Mark R; Hancox, Jules C


    Background inward sodium current (IB,Na) that influences cardiac pacemaking has been comparatively under-investigated. The aim of this study was to determine for the first time the properties and role of IB,Na in cells from the heart's secondary pacemaker, the atrioventricular node (AVN). Myocytes were isolated from the AVN of adult male rabbits and mice using mechanical and enzymatic dispersion. Background current was measured using whole-cell patch clamp and monovalent ion substitution with major voltage- and time-dependent conductances inhibited. In the absence of a selective pharmacological inhibitor of IB,Na, computer modelling was used to assess the physiological contribution of IB,Na. Net background current during voltage ramps was linear, reversing close to 0mV. Switching between Tris- and Na(+)-containing extracellular solution in rabbit and mouse AVN cells revealed an inward IB,Na, with an increase in slope conductance in rabbit cells at -50mV from 0.54±0.03 to 0.91±0.05nS (mean±SEM; n=61 cells). IB,Na magnitude varied in proportion to [Na(+)]o. Other monovalent cations could substitute for Na(+) (Rb(+)>K(+)>Cs(+)>Na(+)>Li(+)). The single-channel conductance with Na(+) as charge carrier estimated from noise-analysis was 3.2±1.2pS (n=6). Ni(2+) (10mM), Gd(3+) (100μM), ruthenium red (100μM), or amiloride (1mM) produced modest reductions in IB,Na. Flufenamic acid was without significant effect, whilst La(3+) (100μM) or extracellular acidosis (pH6.3) inhibited the current by >60%. Under the conditions of our AVN cell simulations, removal of IB,Na arrested spontaneous activity and, in a simulated 1D-strand, reduced conduction velocity by ~20%. IB,Na is carried by distinct low conductance monovalent non-selective cation channels and can influence AVN spontaneous activity and conduction.

  4. Russian electricity market. Current state and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Abdurafikov, R.


    The Russian electricity market is currently in transition. The restructuring of the sector has been completed and former public vertically integrated monopolies have been unbundled and partly privatised. The government retained control in all the network companies, the system operator, nuclear generation, and hydro generation. The state retains control also via owner-ship in several TGCs and WGCs in the strategic regions of Moscow and Saint-Petersburg via the state owned gas monopoly Gazprom. The liberalization takes place within two price zones, Europe and Siberia, where more than 90%, 913 TWh in 2007, of Russian electricity consumption takes place. In the rest of Russia, e.g. the Far East and isolated areas like Kaliningrad, electricity is supplied at regulated rates. Only a minor part of electricity in the price zones is currently traded at free prices. The share of electricity traded at free market prices will increase according to the liberalization schedule, reaching ca 90%, all except households, by 2011. Wholesale electricity market bids are aggregated in a detailed power system model of the Russian power grid, taking into account the physical locations of the facilities. The resulting 7700+ nodal market prices, scattered across the 7 time zones of the Russian market area, capture costs of congestion and load losses in the grid. The price level of electricity seems to be rather low at a glance - about 21 euro and 15 euro per MWh in Europe and Siberia respectively. On the other hand, wholesale market buyers have to pay for capacity availability, on average around 3000 euro/MW monthly. With greater share of electricity traded at free prices there will be an increased need to hedge price risks. For this reason a financial market is planned. There are also plans for support schemes for renewable generation and to limit environmental pollution as well as ancillary services markets. Some areas do not experience a likewise opening of the competition in Russia, for

  5. Current management of obsessive and phobic states

    Directory of Open Access Journals (Sweden)

    Goljevscek S


    Full Text Available Serena Goljevscek1, Livia A Carvalho21Psychiatric Clinic, University of Udine, Udine, Italy; 2Health Science Research Centre, Department of Life Sciences, Roehampton University, London, UKAbstract: Obsessional states show an average point prevalence of 1%–3% and a lifetime prevalence of 2%–2.5%. Most treatment-seeking patients with obsessions continue to experience significant symptoms after 2 years of prospective follow-up. A significant burden of impairment, distress, and comorbidity characterize the course of the illness, leading to an increased need for a better understanding of the nature and management of this condition. This review aims to give a representation of the current pharmacological and psychotherapeutic strategies used in the treatment of obsessive-compulsive disorder. Antidepressants (clomipramine and selective serotonin reuptake inhibitors are generally the first-line choice used to handle obsessional states, showing good response rates and long-term positive outcomes. About 40% of patients fail to respond to selective serotonin reuptake inhibitors. So far, additional pharmacological treatment strategies have been shown to be effective, ie, administration of high doses of selective serotonin reuptake inhibitors, as well as combinations of different drugs, such as dopamine antagonists, are considered efficacious and well tolerated strategies in terms of symptom remission and side effects. Psychotherapy also plays an important role in the management of obsessive-compulsive disorder, being effective for a wide range of symptoms, and many studies have assessed its long-term efficacy, especially when added to appropriate pharmacotherapy. In this paper, we also give a description of the clinical and psychological features likely to characterize patients refractory to treatment for this illness, with the aim of highlighting the need for greater attention to more patient-oriented management of the disease.Keywords: obsessive

  6. Current management of obsessive and phobic states. (United States)

    Goljevscek, Serena; Carvalho, Livia A


    Obsessional states show an average point prevalence of 1%-3% and a lifetime prevalence of 2%-2.5%. Most treatment-seeking patients with obsessions continue to experience significant symptoms after 2 years of prospective follow-up. A significant burden of impairment, distress, and comorbidity characterize the course of the illness, leading to an increased need for a better understanding of the nature and management of this condition. This review aims to give a representation of the current pharmacological and psychotherapeutic strategies used in the treatment of obsessive-compulsive disorder. Antidepressants (clomipramine and selective serotonin reuptake inhibitors) are generally the first-line choice used to handle obsessional states, showing good response rates and long-term positive outcomes. About 40% of patients fail to respond to selective serotonin reuptake inhibitors. So far, additional pharmacological treatment strategies have been shown to be effective, ie, administration of high doses of selective serotonin reuptake inhibitors, as well as combinations of different drugs, such as dopamine antagonists, are considered efficacious and well tolerated strategies in terms of symptom remission and side effects. Psychotherapy also plays an important role in the management of obsessive-compulsive disorder, being effective for a wide range of symptoms, and many studies have assessed its long-term efficacy, especially when added to appropriate pharmacotherapy. In this paper, we also give a description of the clinical and psychological features likely to characterize patients refractory to treatment for this illness, with the aim of highlighting the need for greater attention to more patient-oriented management of the disease.

  7. The Current State of Music Therapy Theory?

    DEFF Research Database (Denmark)

    Bonde, Lars Ole


    An essay on themes from Ken Aigen (2014): "The Study of Music Therapy. Current Issues and Concepts"......An essay on themes from Ken Aigen (2014): "The Study of Music Therapy. Current Issues and Concepts"...

  8. Engineering photorespiration: current state and future possibilities. (United States)

    Peterhansel, C; Krause, K; Braun, H-P; Espie, G S; Fernie, A R; Hanson, D T; Keech, O; Maurino, V G; Mielewczik, M; Sage, R F


    Reduction of flux through photorespiration has been viewed as a major way to improve crop carbon fixation and yield since the energy-consuming reactions associated with this pathway were discovered. This view has been supported by the biomasses increases observed in model species that expressed artificial bypass reactions to photorespiration. Here, we present an overview about the major current attempts to reduce photorespiratory losses in crop species and provide suggestions for future research priorities.

  9. Floating Heavy Oil Recovery: Current State Analysis (United States)


    have taken place over the past seven years on a series of pumps known as positive displacement Archimedes ’ screw pumps commonly used in the oil spill...current research into containment strategies and equipment for heavy viscous oil was uncovered during this study. General principles used to...rotated in the water, it created small waves that caused the trail of bitumen to “break” and be pushed away from the skimmer. Operating the drum at

  10. Establishing policy relevant background (PRB) ozone concentrations in the United States. (United States)

    McDonald-Buller, Elena C; Allen, David T; Brown, Nancy; Jacob, Daniel J; Jaffe, Daniel; Kolb, Charles E; Lefohn, Allen S; Oltmans, Samuel; Parrish, David D; Yarwood, Greg; Zhang, Lin


    Policy Relevant Background (PRB) ozone concentrations are defined by the United States (U.S.) Environmental Protection Agency (EPA) as those concentrations that would occur in the U.S. in the absence of anthropogenic emissions in continental North America (i.e., the U.S, Canada, and Mexico). Estimates of PRB ozone have had an important role historically in the EPA's human health and welfare risk analyses used in establishing National Ambient Air Quality Standards (NAAQS). The margin of safety for the protection of public health in the ozone rulemaking process has been established from human health risks calculated based on PRB ozone estimates. Sensitivity analyses conducted by the EPA have illustrated that changing estimates of PRB ozone concentrations have a progressively greater impact on estimates of mortality risk as more stringent standards are considered. As defined by the EPA, PRB ozone is a model construct, but it is informed by measurements at relatively remote monitoring sites (RRMS). This review examines the current understanding of PRB ozone, based on both model predictions and measurements at RRMS, and provides recommendations for improving the definition and determination of PRB ozone.

  11. Solar photovoltaics: current state and trends (United States)

    Milichko, V. A.; Shalin, A. S.; Mukhin, I. S.; Kovrov, A. E.; Krasilin, A. A.; Vinogradov, A. V.; Belov, P. A.; Simovski, C. R.


    Basic aspects of current solar photovoltaics (PVs) are reviewed, starting from the recently developed already-on-the-market first-generation solar cells and ending with promising but not yet commercialized third-generation cells and materials possibly leading to new cell designs. The emphasis is on the physical principles of operation of various solar cells, which are divided into several groups according to our classification scheme. To make the picture complete, some technological and economic aspects of the field are discussed. A separate chapter considers antireflection coatings and light-trapping textures — structures which, while not having appeared yet in the PV review literature, are an integral part of the solar cells.

  12. Spaceflight osteoporosis: current state and future perspective. (United States)

    Cappellesso, R; Nicole, L; Guido, A; Pizzol, D


    Osteoporosis is one of the established major consequences of long-duration spaceflights in astronauts seriously undermining their health after their returning on Earth. Indeed, astronauts typically lose more bone mass during one month than postmenopausal women on Earth lose in one year. To date, countermeasures mainly consist in exercise and supplementation while pharmacological treatment as those used in postmenopausal women are not routine. However, it is evident that exercise and supplementation alone are not enough to maintain bone homeostasis. In this paper we describe the current countermeasures for bone loss during long-term spaceflight, review the modern treatment which are successfully employed to prevent osteoporosis on Earth and that could be quickly used also for astronauts and finally focus on the recent cellular and molecular understanding of bone homeostasis which might provide the basis for the development of future targeted therapies.

  13. The current state of Socio-hydrology (United States)

    Sivapalan, Murugesu; Viglione, Alberto; Di Baldassarre, Giuliano; Pande, Saket


    Socio-hydrology was introduced 4 years ago into the scientific lexicon, and elicited several reactions about the meaning and originality of the concept. However, there has also been much activity triggered by the original paper, including further commentaries that clarified the definitions, and several papers that acted on the definitions, and through them further clarified and illustrated the meaning and usefulness of socio-hydrology for understanding coupled human-water systems and underpinning sustainable water management. This presentation discusses how useful these recent studies have been towards the need for socio-hydrology to explain phenomena, such as rise and decline of human population or food production in water scarce basins ('pendulum swing'), the levee effect, small scale farmer suicides, anthropogenic droughts, etc… We also discuss its foundation as a Science, its similarities and dissimilarities with other fields that study human-water interactions, such as hydro-sociology and hydro-economics, its foundation as a Science, current gaps and the challenges that lie ahead.

  14. Colleges of Applied Arts and Technology of Ontario. Background Papers on Current Issues. (United States)

    Association of Colleges of Applied Arts and Technology of Ontario, Willowdale.

    Background information is provided on a number of conditions affecting Ontario's community colleges. The first section, dealing with financial issues, considers the college environment in the 1980s; examines the provincial government's perspective on priorities, the allocation process, government funding, and budgetary expenditures and trends; and…

  15. Historical Trust Levels Predict Current Welfare State Design

    DEFF Research Database (Denmark)

    Bergh, Andreas; Bjørnskov, Christian

    Using cross-sectional data for 76 countries, we apply instrumental variable techniques based on pronoun drop, temperature and monarchies to demonstrate that historical trust levels predict several indicators of current welfare state design, including universalism and high levels of regulatory...... welfare state universalism to individual trust, although we claim that the important causal link runs from historically trust levels to current welfare state design....

  16. Influence of Complete Coriolis Force on the Dispersion Relation of Ocean Internal-wave in a Background Currents Field

    Directory of Open Access Journals (Sweden)

    Liu Yongjun


    Full Text Available In this thesis, the influence of complete Coriolis force (the model includes both the vertical and horizontal components of Coriolis force on the dispersion relation of ocean internal-wave under background currents field are studied, it is important to the study of ocean internal waves in density-stratified ocean. We start from the control equation of sea water movement in the background of the non-traditional approximation, and the vertical velocity solution is derived where buoyancy frequency N(z gradually varies with the ocean depth z. The results show that the influence of complete Coriolis force on the dispersion relation of ocean internal-wave under background currents field is obvious, and these results provide strong evidence for the understanding of dynamic process of density stratified ocean internal waves.

  17. Background, Current Situation and International Experience of Food and Drug Police System

    Institute of Scientific and Technical Information of China (English)

    Hui; QIAO; Xu; WANG; Man; ZHANG; Fengtian; ZHENG


    Establishing the food and drug police system is particularly important for effectively striking at illegal and criminal activities related to food and drug. This study firstly revealed actual background of establishment of the food and drug police system. Taking the high profile gutter oil case in 2013 as an example,it analyzed advantages of the police in food safety supervision. Then,it summarized some pilot projects in China and analyzed characteristics of the Office of Criminal Investigations of FDA. Finally,it came up with problems and recommendations for improving food and drug police system.

  18. Development of Social Work Education in China: Background, Current Status, and Prospects (United States)

    Li, Yingsheng; Han, Wen-Jui; Huang, Chien-Chung


    China's social work education dates back to the 1920s, but the profession disappeared for 36 years after the establishment of the People's Republic of China. Not until the late 1980s was social work education in China revived. At the turn of the new century, the Central Committee of the Chinese Communist Party and the State Council supported the…

  19. Correlations in background activity control persistent state stability and allow execution of working memory tasks

    Directory of Open Access Journals (Sweden)

    Mario eDipoppa


    Full Text Available Working memory (WM is tightly capacity limited, it requires selective information gating, active information maintenance, and rapid active updating. Hence performing a WM task needs rapid and controlled transitions between neural persistent activity and the resting state. We propose that changes in spike-time correlations in neural activity provides a mechanism for the required working memory operations. As a proof of principle, we implement sustained activity and working memory in a recurrently-coupled spiking network with neurons receiving excitatory random background activity where background correlations are induced by a common noise source. We first characterize how the level of background correlations controls the stability of the persistent state. With sufficiently high correlations, the sustained state becomes practically unstable, so it cannot be initiated by a transient stimulus. We exploit this in a working memory model implementing the delay match to sample task by modulating flexibly in time the correlation level at different phases of the task. The modulation sets the network in different working regimes: more prompt to gate in a signal or clear the memory. The findings presented in this manuscript can form the basis for a new paradigm about how correlations are flexibly controlled by the cortical circuits to execute WM operations.

  20. Stable and unstable thermo -current states of high temperature superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Romanovskii, V; Lavrov, N; Ozhogina, V [Russian Research Center ' Kurchatov Institute' , Moscow 123182 (Russian Federation)], E-mail:


    Formation peculiarities of the stable and unstable states of high-T{sub c} superconductors are discussed. To understand the basic physical trends, which are characteristic for the current penetration mechanism in high temperature superconductors, the operating states of Bi2212 slab without stabilizing matrix placed in DC external magnetic fields at low coolant temperature are theoretically investigated. It is proved that the temperature of a high-T{sub c} superconductor is not equals to the coolant temperature before instability onset. Therefore, the voltage-current characteristic of a high-T{sub c} superconductor has only a positive slope during continuous current charging. As a result, it does not allow one to find the boundary between stable and unstable thermo - current states. This peculiarity has to be considered during experiments at which the critical current of high-T{sub c} superconductors is defined.

  1. Testing Literature: The Current State of Affairs. ERIC Digest. (United States)

    Purves, Alan C.

    A synthesis of the report, "The Current State of Assessment in Literature," (produced by the Center for the Learning and Teaching of Literature), this digest discusses methods of evaluating students' knowledge of literature. The digest argues that, by and large, the tests that now exist in the United States do not live up to the standards set by…

  2. Urban enhancement of PM10 bioaerosol tracers relative to background locations in the Midwestern United States (United States)

    Rathnayake, Chathurika M.; Metwali, Nervana; Baker, Zach; Jayarathne, Thilina; Kostle, Pamela A.; Thorne, Peter S.; O'Shaughnessy, Patrick T.; Stone, Elizabeth A.


    Bioaerosols are well-known immune-active particles that exacerbate respiratory diseases. Human exposures to bioaerosols and their resultant health impacts depend on their ambient concentrations, seasonal and spatial variation, and copollutants, which are not yet widely characterized. In this study, chemical and biological tracers of bioaerosols were quantified in respirable particulate matter (PM10) collected at three urban and three background sites in the Midwestern United States across four seasons in 2012. Endotoxins from Gram-negative bacteria (and a few Gram-positive bacteria), water-soluble proteins, and tracers for fungal spores (fungal glucans, arabitol, and mannitol) were ubiquitous and showed significant seasonal variation and dependence on temperature. Fungal spores were elevated in spring and peaked in summer, following the seasonal growing cycle, while endotoxins peaked in autumn during the row crop harvesting season. Paired comparisons of bioaerosols in urban and background sites revealed significant urban enhancements in PM10, fungal glucans, endotoxins, and water-soluble proteins relative to background locations, such that urban populations have a greater outdoor exposure to bioaerosols. These bioaerosols contribute, in part, to the urban excesses in PM10. Higher bioaerosol mass fractions in urban areas relative to background sites indicate that urban areas serve as a source of bioaerosols. Similar urban enhancements in water-soluble calcium and its correlation with bioaerosol tracers point toward windblown soil as an important source of bioaerosols in urban areas.

  3. Mapping current fluctuations of stochastic pumps to nonequilibrium steady states (United States)

    Rotskoff, Grant M.


    We show that current fluctuations in a stochastic pump can be robustly mapped to fluctuations in a corresponding time-independent nonequilibrium steady state. We thus refine a recently proposed mapping so that it ensures equivalence of not only the averages, but also optimal representation of fluctuations in currents and density. Our mapping leads to a natural decomposition of the entropy production in stochastic pumps similar to the "housekeeping" heat. As a consequence of the decomposition of entropy production, the current fluctuations in weakly perturbed stochastic pumps are shown to satisfy a universal bound determined by the steady state entropy production.

  4. Created-by-current states in long Josephson junctions (United States)

    Boyadjiev, T. L.; Andreeva, O. Yu.; Semerdjieva, E. G.; Shukrinov, Yu. M.


    Critical curves "critical current-external magnetic field" of long Josephson junctions with inhomogeneity and variable width are studied. We demonstrate the existence of regions of magnetic field where some fluxon states are stable only if the external current through the junction is different from zero. Position and size of such regions depend on the length of the junction, its geometry, parameters of inhomogeneity and form of the junction. The noncentral (left and right) pure fluxon states appear in the inhomogeneous Josephson junction with the increase in the junction length. We demonstrate new bifurcation points with change in width of the inhomogeneity and amplitude of the Josephson current through the inhomogeneity.

  5. Layer-by-layer assembled carbon nanotube films with molecule recognition function and lower capacitive background current. (United States)

    Kong, Bo; Zeng, Jinxiang; Luo, Guangming; Luo, Shenglian; Wei, Wanzhi; Li, Jun


    Multilayer films of multiwalled carbon nanotubes (MWCNTs) with molecule recognition function were assembled on glassy carbon (GC) electrode with lower capacitive background current by two steps: first, MWCNTs interacted with beta-cyclodextrin (beta-CD) with the aid of sonication to form beta-CD-MWCNTs nanocomposite, then the beta-CD-MWCNTs nanocomposite was assembled on GC electrode using layer-by-layer (LBL) method based on electrostatic interaction of positively charged biopolymer chitosan and negatively charged MWCNTs. The assembled beta-CD-MWCNTs multilayer films were characterized by scanning electron microscopy (SEM) and cyclic voltammetry. The SEM indicated that the MWCNTs multilayer films with beta-CD were somewhat more compact than that of the MWCNTs multilayer films without beta-CD. The cyclic voltammetric results indicated that the assembled MWCNTs with beta-CD on GC electrode exhibited lower capacitive background current than the assembled MWCNTs without beta-CD. The MWCNTs multilayer films with beta-CD were studied with respect to the electrocatalytic activity toward dopamine (DA). Compared with the MWCNTs multilayer films without beta-CD, the MWCNTs multilayer films with beta-CD possesses a much lower capacitive background current and higher electrocatalytic activity in phosphate buffer, which was ascribed to the relatively compact three-dimensional structure of the MWCNTs multilayer films with beta-CD and the excellent molecule recognition function of beta-CD.

  6. Multistable current states in high-temperature superconducting composites (United States)

    Romanovskii, V. R.


    Conditions for current instabilities that arise in high-temperature superconducting composites with essentially nonlinear dependences of the critical current densities and resistivity on the temperature and magnetic induction have been studied. The analysis has been conducted in terms of zero-dimensional models, which has made it possible to formulate general physical mechanisms behind the formation of currents states in superconducting composites according to the external magnetic field induction, cooling conditions, and the properties of the superconductor and cladding. The possible existence of current and temperature stable steps, as well as stable steps of the electric field strength, in the absence of the superconducting-normal transition, has been demonstrated. Reasons for instabilities under multistable current states have been discussed.

  7. Transient and steady-state currents in epoxy resin

    Energy Technology Data Exchange (ETDEWEB)

    Guillermin, Christophe [Schneider Electric Industries S.A.S., 37 quai Paul-Louis Merlin, 38050 Grenoble Cedex 9 (France); Rain, Pascal [Laboratoire d' Electrostatique et de Materiaux Dielectriques (LEMD), CNRS, 25 avenue des Martyrs, 38042 Grenoble Cedex 9 (France); Rowe, Stephen W [Schneider Electric Industries S.A.S., 37 quai Paul-Louis Merlin, 38050 Grenoble Cedex 9 (France)


    Charging and discharging currents have been measured in a diglycidyl ether of bisphenol-A epoxy resin with and without silica fillers, below and above its glass transition temperature T{sub g} = 65 deg. C. Both transient and steady-state current densities have been analysed. The average applied fields ranged from 3 to 35 kV mm{sup -1} with a sample thickness of 0.5 mm. Above T{sub g}, transient currents suggested a phenomenon of charge injection forming trapped space charges even at low fields. Steady-state currents confirmed that the behaviour was not Ohmic and suggested Schottky-type injection. Below T{sub g}, the current is not controlled by the metal-dielectric interface but by the conduction in the volume: the current is Ohmic at low fields and both transient and steady-state currents suggest a phenomenon of space-charge limited currents at high fields. The field threshold is similar in the filler-free and the filled resin. Values in the range 12-17 kV mm{sup -1} have been measured.

  8. The European Drought Observatory (EDO): Current State and Future Directions (United States)

    Vogt, Jürgen; Sepulcre, Guadalupe; Magni, Diego; Valentini, Luana; Singleton, Andrew; Micale, Fabio; Barbosa, Paulo


    Europe has repeatedly been affected by droughts, resulting in considerable ecological and economic damage and climate change studies indicate a trend towards increasing climate variability most likely resulting in more frequent drought occurrences also in Europe. Against this background, the European Commission's Joint Research Centre (JRC) is developing methods and tools for assessing, monitoring and forecasting droughts in Europe and develops a European Drought Observatory (EDO) to complement and integrate national activities with a European view. At the core of the European Drought Observatory (EDO) is a portal, including a map server, a metadata catalogue, a media-monitor and analysis tools. The map server presents Europe-wide up-to-date information on the occurrence and severity of droughts, which is complemented by more detailed information provided by regional, national and local observatories through OGC compliant web mapping and web coverage services. In addition, time series of historical maps as well as graphs of the temporal evolution of drought indices for individual grid cells and administrative regions in Europe can be retrieved and analysed. Current work is focusing on validating the available products, developing combined indicators, improving the functionalities, extending the linkage to additional national and regional drought information systems and testing options for medium-range probabilistic drought forecasting across Europe. Longer-term goals include the development of long-range drought forecasting products, the analysis of drought hazard and risk, the monitoring of drought impact and the integration of EDO in a global drought information system. The talk will provide an overview on the development and state of EDO, the different products, and the ways to include a wide range of stakeholders (i.e. European, national river basin, and local authorities) in the development of the system as well as an outlook on the future developments.

  9. Bulgarian-Polish Language Resources (Current State and Future Development

    Directory of Open Access Journals (Sweden)

    Ludmila Dimitrova


    Full Text Available Bulgarian-Polish Language Resources (Current State and Future Development The paper briefly reviews the first Bulgarian-Polish digital bilingual resources: corpora and dictionaries, which are currently developed under bilateral collaboration between IMI-BAS and ISS-PAS: joint research project “Semantics and contrastive linguistics with a focus on a bilingual electronic dictionary”, coordinated by L. Dimitrova (IMI-BAS and V. Koseska (ISS-PAS.

  10. Visualization and data analysis-current state and exascale challenges

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, James P [Los Alamos National Laboratory; Rodgers, David [SNL; Springmeyer, Becky [LLNL


    Talk about Visualization and Data Analysis Current State and Exascale challenges. The goal is to update with colleagues our current status in our research. What challenges we need to face, and what future possibilities. Our goal is to propose to approach the problems with the visualization approach operating on the supercomputing platform. This presentation is about the L2 Milestone, we intend to discuss further possibilities of enhancing our results and optimizing our solutions.

  11. Quantum quasi-steady states in current transport (United States)

    D'Agosta, Roberto; Zwolak, Michael; di Ventra, Massimiliano


    We investigate quasi-steady state solutions to transport in quantum systems by finding states which at some time minimize the change in density throughout all space and have a given current density flowing from one part of the system to another [1]. Contrary to classical dynamics, in a quantum mechanical system there are many states with a given energy and particle number which satisfy this minimization criterion. Taking as an example spinless fermions on a one-dimensional lattice, we explicitly show the phase space of a class of quasi-steady states. We also discuss the possibility of coherent and incoherent mixing of these steady state solutions leading to a new type of noise in quantum transport. [1] M. Di Ventra and T.N. Todorov J. Phys. Cond. Matt. 16, 8025 (2004).

  12. Current state management of the consumer capital of domestic enterprises


    E.O. Golysheva


    In the article the analysis of the current state of management by consumer business capital is carried out. It is based on three components: system of communications with consumers and external subjects, the history of relationship with them and the database about partners; portfolio management of trade marks (brands); the.

  13. The Current State of Marketing Activity among Higher Education Institutions. (United States)

    Newman, Cynthia M.


    Investigated the current state of marketing, marketing research, and planning practices at four-year higher education institutions. Builds upon previous studies by Blackburn (1979) and Goldgehn (1982 and 1989). Determined whether the use and apparent understanding of marketing and its attendant activities by admissions and enrollment management…

  14. Sustainable practices in medicinal chemistry: current state and future directions. (United States)

    Bryan, Marian C; Dillon, Barry; Hamann, Lawrence G; Hughes, Gregory J; Kopach, Michael E; Peterson, Emily A; Pourashraf, Mehrnaz; Raheem, Izzat; Richardson, Paul; Richter, Daniel; Sneddon, Helen F


    The medicinal chemistry subgroup of the American Chemical Society's Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of environmentally sustainable practices in medicinal chemistry with the aim of sharing best practices more widely and highlighting some potential future developments.

  15. Current state management of the consumer capital of domestic enterprises

    Directory of Open Access Journals (Sweden)

    E.O. Golysheva


    Full Text Available In the article the analysis of the current state of management by consumer business capital is carried out. It is based on three components: system of communications with consumers and external subjects, the history of relationship with them and the database about partners; portfolio management of trade marks (brands; the.

  16. Quark effects, meson-exchange currents and background in the d(e, e[sup primep])[Delta] reaction

    Energy Technology Data Exchange (ETDEWEB)

    Gomez Tejedor, J.A. (Institut fuer Theoretische Physik der Universitaet Tuebingen, Tuebingen (Germany)); Oset, E. (Institut fuer Theoretische Physik der Universitaet Tuebingen, Tuebingen (Germany))


    We have studied in detail the cross section for the d(e, e[sup primep])[Delta] reaction leading to the emission of a fast nucleon and a [Delta] at rest, which has been advocated as a tool to investigate quark effects in nuclei. We find that ordinary meson-exchange currents mechanisms dominate the quark-exchange effects in the region of excitation of the [Delta] and could be competitive at higher energies. Furthermore, at these higher energies, the small cross sections for the quark signal, together with the presence of a background about one order of magnitude bigger than the quark signal, make in any case the extraction of information about quark-exchange currents effects extraordinarily difficult. ((orig.))

  17. Effects of QCD equation of state on the stochastic gravitational wave background (United States)

    Anand, Sampurn; Dey, Ujjal Kumar; Mohanty, Subhendra


    Cosmological phase transitions can be a source of Stochastic Gravitational Wave (SGW) background. Apart from the dynamics of the phase transition, the characteristic frequency and the fractional energy density Ωgw of the SGW depends upon the temperature of the transition. In this article, we compute the SGW spectrum in the light of QCD equation of state provided by the lattice results. We find that the inclusion of trace anomaly from lattice QCD, enhances the SGW signal generated during QCD phase transition by ~ 50% and the peak frequency of the QCD era SGW are shifted higher by ~ 25% as compared to the earlier estimates without trace anomaly. This result is extremely significant for testing the phase transition dynamics near QCD epoch.

  18. Evolution of the Coronal Magnetic Configurations Including a Current-Carrying Flux Rope in Response to the Change in the Background Field

    CERN Document Server

    Wang, Hong-Juan; Gong, Jian-Cun; Lin, Jun


    We investigate equilibrium height of the flux rope, and its internal equilibrium in a realistic plasma environment by carrying out numerical simulations of the evolution of systems including a current-carrying flux rope. We find that the equilibrium height of the flux rope is approximately a power-law function of the relative strength of the background field. Our simulations indicate that the flux rope can escape more easily from a weaker background field. This further confirms the catastrophe in the magnetic configuration of interest can be triggered by decrease of strength of the background field. Our results show that it takes some time to reach internal equilibrium depending on the initial state of the flux rope. The plasma flow inside the flux rope due to the adjustment for the internal equilibrium of the flux rope remains small and does not last very long when the initial state of the flux rope commences from the stable branch of the theoretical equilibrium curve. This work also confirms the influence o...

  19. Phase state dependent current fluctuations in pure lipid membranes

    CERN Document Server

    Wunderlich, B; Idzko, A-L; Keyser, U F; Wixforth, A; Myles, V M; Heimburg, T; Schneider, M F


    Current fluctuations in pure lipid membranes have been shown to occur under the influence of transmembrane electric fields (electroporation) as well as a result from structural rearrangements of the lipid bilayer during phase transition (soft perforation). We demonstrate that the ion permeability during lipid phase transition exhibits the same qualitative temperature dependence as the macroscopic heat capacity of a D15PC/DOPC vesicle suspension. Microscopic current fluctuations show distinct characteristics for each individual phase state. While current fluctuations in the fluid phase show spike-like behaviour of short time scales (~ 2ms) with a narrow amplitude distribution, the current fluctuations during lipid phase transition appear in distinct steps with time scales in the order of ~ 20ms. 1 We propose a theoretical explanation for the origin of time scales and permeability based on a linear relationship between lipid membrane susceptibilities and relaxation times in the vicinity of the phase transition.

  20. Current State and Issues of Logistics Cost Accounting and Management in Malaysia


    Zakariah, Sahidah; Pyeman, Jaafar


    Background: Logistics cost is an important factor affecting the competitiveness on both macro (national) and micro level (firms). Logistics cost indicates the performance of logistics industry, efficiency level and its competitiveness. Research Problem: Despite of its significance, current state of logistics cost accounting and management in Malaysia has not properly addressed and the issues surround logistics cost measurement remains incoherent. Aim of research: The purpose o...

  1. Composition and mixing state of the urban background aerosol in the Rhein-Main area (Germany) (United States)

    Vester, Barbara P.; Ebert, Martin; Barnert, Eric B.; Schneider, Johannes; Kandler, Konrad; Schütz, Lothar; Weinbruch, Stephan

    Size-resolved aerosol particle samples in the size range 0.1-10 μm aerodynamic diameter were collected in the years 2003 and 2004 at an urban background station in Mainz, Germany. Size, morphology, chemical composition and mixing state of more than 5400 individual particles of 7 selected sampling days were analyzed in detail by scanning electron microscopy and energy-dispersive X-ray microanalysis. In addition, transmission electron microscopy, aerosol mass spectrometry and atomic force microscopy were applied to obtain detailed information about the mixing state of the particles. The fine particle fraction (diameterparticles (⩾90% by number) independent from air mass origin. These particles are complex internal mixtures of ammonium and sodium sulfates, nitrates, and organic material. Between 20% and 40% of the complex secondary aerosol particles contain soot inclusions. The composition of the coarse particle fraction (>1 μm diameter) is strongly dependant on air mass history with variable abundances of complex secondary aerosol particles, aged sea salt, silicates, silicate mixtures, calcium sulfates, calcium sulfate/carbonate mixtures, calcium nitrate/carbonate mixtures, biological particles, and external soot. The dominance of complex secondary aerosol particles shows that reduction of the precursor gases is a major goal for successful reduction strategies for PM 10.

  2. Current trends in state child labor legislation and enforcement. (United States)

    Beyer, D


    There is much current child labor law activity, none of it reflecting concern with occupational health hazards. The focus of the legislation is on time for and dedication to education as youth's foremost priority. The only areas of state legislative change that could affect children's health and safety in the workplace are a general movement toward monetarily increasing fines and penalties and some minor inclusions of agricultural restrictions on young workers. Enforcement efforts are in all cases a primary indication of state commitment to child labor law protections, and these efforts are decreasing.

  3. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt


    The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer to a spe......The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer...... which simultaneously tracks the translator’s eye movements across a screen displaying both a source text and the translator’s emerging translation. This research method was developed as a means of qualifying and strengthening translation process hypotheses based on verbal reports by providing additional...

  4. The Development and Current State of Translation Process Research

    DEFF Research Database (Denmark)

    Lykke Jakobsen, Arnt


    The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer to a spe......The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer...... to a special descriptive, empirical, experimental approach to translation studies based on close, technology-supported observation of translational (micro)behaviour. Fundamentally, TPR is based on software which logs a translator’s keystrokes on a computer keyboard in time in combination with an eyetracker...

  5. [The current state and development prospectives of military nephrology]. (United States)

    Nagibovich, O A; Golota, A S; Krassiĭ, A B


    This article is dedicated to the current state and prospectives of military nephrology. Using as examples the nephrology services of the armed forces of Serbia, France, Great Britain and USA it is shown that this branch of military healthcare plays an important role abroad. The brief review of military nephrology formation and development history demonstrates the growing significance of military nephrology in the general system of medical care at the battlefield.


    Directory of Open Access Journals (Sweden)

    M. E. Kim


    Full Text Available The overview data for the syrups formulation, including syrups for children, with synthetic substances were represented: assortment, composition, technological approach. The advantages and disadvantages of this dosage form were described. Details considered flavoring agents and other auxiliaries (stabilizers, preservatives, thickeners comprising syrups were closely examined. The issues of current research state of syrups for children were described.

  7. Local Hubble Expansion: Current State of the Problem

    CERN Document Server

    Dumin, Yurii V


    We present a brief qualitative overview of the current state of the problem of Hubble expansion at the sufficiently small scales (e.g., in planetary systems or local intergalactic volume). The crucial drawbacks of the available theoretical treatments are emphasized, and the possible ways to avoid them are outlined. Attention is drawn to a number of observable astronomical phenomena that could be naturally explained by the local Hubble expansion.

  8. Analysis of current state and prospects of steel production development (United States)

    Protopopov, E. V.; Feyler, S. V.


    Data on world production of steel in the XXI century are provided. Analysis of current state and prospects of ferrous metallurgy development in the Russian Federation is carried out. Results of national steel production performance during 10 months of the year 2015 are given for different countries. Analysis of the main directions of metallurgical equipment import substitution aimed at technological independence in the industry is made. Russian ferrous metallurgy development predictions in its’ main directions up to 2030 is provided.

  9. The United States Navy and Israeli Navy: Background, Current Issues, Scenarios, and Prospects (United States)


    century. Throughout this narrative, key topics in USN-IN relations are explored. These include the impact of Israel’s sinking of the USS Liberty...the USS Liberty (AGTR-5), a technical research ship on an intelligence mission in the eastern Mediterranean. On the morning of June 8, the fourth...Cited in Edwin S. Cochran , “Israel’s Nuclear History,” Israel Affairs VI (Spring/Summer 2000), p. 149. 26 Among those outside the military

  10. [Current state and prospects of military personnel health monitoring]. (United States)

    Rezvantsev, M V; Kuznetsov, S M; Ivanov, V V; Zakurdaev, V V


    The current article is dedicated to some features of the Russian Federation Armed Forces military personnel health monitoring such as legal and informational provision, methodological basis of functioning, historical aspect of formation and development of the social and hygienic monitoring in the Russian Federation Armed Forces. The term "military personnel health monitoring" is defined as an analytical system of constant and long-term observation, analysis, assessment, studying of factors determined the military personnel health, these factors correlations, health risk factors management in order to minimize them. The current state of the military personnel health monitoring allows coming to the conclusion that the military health system does have forces and resources for state policy of establishing the population health monitoring system implementation. The following directions of the militarily personnel health monitoring improvement are proposed: the Russian Federation Armed Forces medical service record and report system reorganization bringing it closer to the civilian one, implementation of the integrated approach to the medical service informatisation, namely, military personnel health status and medical service resources monitoring. The leading means in this direction are development and introduction of a military serviceman individual health status monitoring system on the basis of a serviceman electronic medical record card. Also it is proposed the current Russian Federation Armed Forces social and hygienic monitoring improvement at the expense of informational interaction between the two subsystems on the basis of unified military medical service space.

  11. Microbial production of hyaluronic acid: current state, challenges, and perspectives

    Directory of Open Access Journals (Sweden)

    Liu Long


    Full Text Available Abstract Hyaluronic acid (HA is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.

  12. Radical Islam in Xinjiang – Evolution and Current State

    Directory of Open Access Journals (Sweden)

    Jiri Suchanek


    Full Text Available The article analyses the evolution and the current state of radical Islam in China’s Xinjiang Uyghur Autonomous Region. Chinese government considers Islamic radicalism as a serious threat, in particular in the Xinjiang region, which borders on some states in Central Asia as well as Pakistan and Afghanistan. The purpose of this article is to describe and evaluate roots and historical development of significant groups, in particular the East Turkestan Islamic Movement – ETIM. In its next part, the article deals with the contemporary situation as well as the cooperation between Uyghur radicals and other radical Islamic movements, in particular al-Qaeda and Taliban, and their activities. The article concludes that contemporary Uyghur Islamic radicalism cannot be considered as a major security threat, since the activities of these groups have largely shifted to Pakistan and rather have the nature of a propaganda war.

  13. The evolution and current state of emergency care in Ghana

    Directory of Open Access Journals (Sweden)

    Maxwell Osei-Ampofo


    Full Text Available Emergency Medicine as a specialty has only recently been introduced to Ghana. This article reviews the overall health and medical care systems as well as the evolution and the current state of emergency care in Ghana and the progress made in establishing Emergency Medicine (EM as a specialty along the Anglo-American model of emergency care. The article also describes the improvements implemented in emergency patient care, and emergency medicine management systems. Although there are challenges to overcome, much optimism remains about the future of this new specialty in Ghana and its ability to transform the face of emergency care.

  14. The current state of molecular cytogenetics in cancer diagnosis. (United States)

    Liehr, Thomas; Othman, Moneeb A K; Rittscher, Katharina; Alhourani, Eyad


    Cytogenetics and molecular cytogenetics are and will continue to be indispensable tools in cancer diagnostics. Leukemia and lymphoma diagnostics are still emphases of routine (molecular) cytogenetics and corresponding studies of solid tumors gain more and more prominence. Here, first a historical perspective of molecular tumor cytogenetics is provided, which is followed by the basic principles of the fluorescence in situ hybridization (FISH) approach. Finally the current state of molecular cytogenetics in cancer diagnostics is discussed. Nowadays routine diagnostics includes basic FISH approaches rather than multicolor-FISH. The latter together with modern high-throughput methods have their impact on research to identify new tumor-associated genomic regions.

  15. Estimation of thyroid gland state of voles natural populations from increased radioactive background territories

    Energy Technology Data Exchange (ETDEWEB)

    Raskosha, O.; Ermakova, O.; Kaneva, A. [Institute of Biology of Komi Scientific Center, Ural Division of Russian Academy of Science (Russian Federation)


    Investigation of effects caused in biological objects by chronic low-intensity radiation in their natural habitats is one of the most important problems of modern radioecology. The aim of our work - complex estimation of state of thyroid gland of voles inhabiting increased radioactive background territories. We investigated tundra voles (Microtus oeconomus Pall.) that were sampled at different stages of population cycle from the experimental and the control sites in the Uhta region of the Komi Republic, Russia. Experimental site contamination resulted from commercial extraction od radium between the 1930's and 1950's. Irradiation exposure dose at the site was 50-2000 mR/h (at the control site 10-15 mR/h). Complex estimation of thyroid was made by histological, morpho-metrical, radioimmunological and cytogenetic methods. Results showed high sensitivity of thyroid gland of tundra voles from chronically irradiated natural populations. We found reliable changes in morphological features of thyroid, in the level of thyroidal hormones and increased frequency of cells with micro-nucleuses in animals sampled from the experimental site as compared with the control ones. It was also showed, that chronic exposure of ionizing irradiation at the same range of absorbed doses can cause different effects in animals depending on sex, age and the stage of population cycle. This confirms the need of including these biological factors to analysis of low doses effects in the natural populations during radioecological studies. Investigations were supported by RFBR grants No. 13-04-01750? and No. 13-04-90351-RBUa. Document available in abstract form only. (authors)


    Directory of Open Access Journals (Sweden)

    N. N. Yurchenko


    Full Text Available The article is devoted to problems of administrative and political governance in Russia in the context of social unrest. The analysis of the situation prevailing in contemporary Russian society and the factors contributing to increased social tensions. It is noted that in the current environment, the organization of the system of administrative and political governance is a key factor in the reduction of tension in the social ecology. In the process of administrative and political management of social conflict is important to consider the stage of its formation and development. The parameters of variability, the variability of political behavior in complex space is a multi-ethnic society are fixed on the basis of monitoring ethno-social interactions, as well as methods of event analysis and cognitive mapping. For sustainable development of the Russian state, there is a need for timely anticipation and prevention of dangerous trends in the growth of social tension that, in turn, indicates the need for continuous improvement of all activities of public authorities, including supervision and management. These circumstances require leadership fundamentally new approaches to the administrative and political management, based on advanced, forward-looking information, allowing you to move from reactive management to proactive government and regional regulation, in a timely manner recognizing potential threats.

  17. EnviroAtlas - MSPA connectivity with water as background for the conterminous United States (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset categorizes land cover into structural elements (e.g. core, edge, connector, etc.). Water is treated as background in this dataset. This...

  18. Imaging of lumbar degenerative disk disease: history and current state

    Energy Technology Data Exchange (ETDEWEB)

    Emch, Todd M. [Cleveland Clinic, Division of Neuroradiology, Imaging Institute, Neuroradiology L-10, Cleveland, OH (United States); Modic, Michael T. [Cleveland Clinic, Division of Neuroradiology, Imaging Institute, Neurological Institute T-13, Cleveland, OH (United States)


    One of the most common indications for performing magnetic resonance (MR) imaging of the lumbar spine is the symptom complex thought to originate as a result of degenerative disk disease. MR imaging, which has emerged as perhaps the modality of choice for imaging degenerative disk disease, can readily demonstrate disk pathology, degenerative endplate changes, facet and ligamentous hypertrophic changes, and the sequelae of instability. Its role in terms of predicting natural history of low back pain, identifying causality, or offering prognostic information is unclear. As available modalities for imaging the spine have progressed from radiography, myelography, and computed tomography to MR imaging, there have also been advances in spine surgery for degenerative disk disease. These advances are described in a temporal context for historical purposes with a focus on MR imaging's history and current state. (orig.)

  19. Critical state model with anisotropic critical current density

    CERN Document Server

    Bhagwat, K V; Ravikumar, G


    Analytical solutions of Bean's critical state model with critical current density J sub c being anisotropic are obtained for superconducting cylindrical samples of arbitrary cross section in a parallel geometry. We present a method for calculating the flux fronts and magnetization curves. Results are presented for cylinders with elliptical cross section with a specific form of the anisotropy. We find that over a certain range of the anisotropy parameter the flux fronts have shapes similar to those for an isotropic sample. However, in general, the presence of anisotropy significantly modifies the shape of the flux fronts. The field for full flux penetration also depends on the anisotropy parameter. The method is extended to the case of anisotropic J sub c that also depends on the local field B, and magnetization hysteresis curves are presented for typical values of the anisotropy parameter for the case of |J sub c | that decreases exponentially with |B|.

  20. Trap States in Copper Phthalocyanine Thin Films using Photogenerated Currents (United States)

    Gredig, Thomas; Guerra, Jorge; Byrne, Matthew; Silverstein, Evan


    The efficiency of organic solar cells is limited by several factors including the photocurrent generation process. Copper phthalocyanine thin films with different grain structures are prepared via thermal evaporation onto interdigitated gold electrodes. The samples are analyzed with atomic force microscopy and then exposed to light pulses to explore the time dependence of photogenerated currents in phthalocyanine thin films. The average grain size is obtained from the correlation length of the height-height correlation function and varies from 30-200nm. The dependence of the recombination of photo-excited, dissociated charge pairs on the electric field is compared with the Onsager mechanism and a simple dual trap state model from which relevant time scales are extracted.

  1. Current state of the cotton and textile industry in Kazakhstan

    Directory of Open Access Journals (Sweden)

    Gulfari Azhimetova


    Full Text Available The textile industry of Kazakhstan is presented basically by enterprises created in period of centrally planned economy and as consequence. Low labor productivity, lacking equipment base and technologies, poor marketing are problems of the current state of industry. But, there are also advantages as a vicinity of potential cotton manufacturers - Uzbekistan, Tajikistan, Turkmenistan. A free economic zone (FEZ “Ontustik” has been established and a program of “Ontustik” FEZ development has been adopted for developing the cotton and textile cluster in Kazakhstan. The law “About development of the cotton branch” has been adopted in Kazakhstan to provide the textile enterprises with necessary raw material and to develop the domestic cotton growing.

  2. The Current State of Silicone-Based Dielectric Elastomer Transducers

    DEFF Research Database (Denmark)

    Madsen, Frederikke Bahrt; Daugaard, Anders Egede; Hvilsted, Søren;


    driving voltages. In this review, the current state of sili- cone elastomers for DETs is summarised and critically discussed, including commercial elastomers, composites, polymer blends, grafted elastomers and complex network structures. For future developments in the field it is essential that all aspects...... class of transducer due to their inherent lightweight and potentially large strains. For the field to progress towards industrial implementation, a leap in material devel- opment is required, specifically targeting longer lifetime and higher energy densities to provide more efficient transduction at lower...... of the elastomer are taken into account, namely dielectric losses, life- time and the very often ignored polymer network integrity and stability....

  3. The Current State and Perspectives of Systems Biology

    Institute of Scientific and Technical Information of China (English)

    Tielui Shi; Yixue Li


    Emerging as a new field in biology recently, Systems Biology provides a branch new way to study the biological activities in organisms. In order to decode the complexity of life systematically,systems biology integrates the "-omics" and uses the high throughput methods from transcriptomics,protomics and metabonomics to detect the dynamic activities in cell; and then, it incorporates bioinformatics methods to integrate and analyze those data, and simulate the biological processes based on the model built from those integrated data. In this paper, the current state, the research field and the methods for the Systems Biology are introduced briefly, and then, several ideas about future development in this field are also proposed.

  4. The current state of industry development in Ukraine: advance perspective

    Directory of Open Access Journals (Sweden)

    Skyba Maryna Valeriyivna


    Full Text Available The current state of the industry of Ukraine are considered at the article. The author determined that the stabilization of the situation and further development of the industry need first of all cessation of hostilities. It is necessary to implement effective measures to combat corruption, the development of consistent, constructive and concerted action on the formation of institutions guaranteeing stability, predictability and transparency of the market rules and procedures that minimize the impact of shadow factors, and implementation of professional privatization and limitation of monopoly at the markets, forming a transparent, competitive business environment, the introduction of new energy saving technologies. These measures will help attract investment, increase production and improve enterprise profitability.

  5. Steady-state and non-steady state operation of counter-current chromatography devices. (United States)

    Kostanyan, Artak E; Ignatova, Svetlana N; Sutherland, Ian A; Hewitson, Peter; Zakhodjaeva, Yulya A; Erastov, Andrey A


    Different variants of separation processes based on steady-state (continuous sample loading) and non-steady state (batch) operating modes of CCC columns have been analyzed and compared. The analysis is carried out on the basis of the modified equilibrium cell model, which takes into account both mechanisms of band broadening - interphase mass transfer and axial mixing. A full theoretical treatment of the intermittent counter-current chromatography with short sample loading time is performed. Analytical expressions are presented allowing the simulation of the intermittent counter-current chromatography separations for various experimental conditions. Chromatographic and extraction separations have been compared and advantages and disadvantages of the two methods have been evaluated. Further technical development of the CCC machines to implement counter-current extraction separations is considered.

  6. Western and Traditional Educational Background of Midwives and Delivery Pain Control among Women in Cross River State, Nigeria (United States)

    Oyira, Emilia James; Emon, Umoe Duke; Essien, N. C.; Ekpenyong, Affiong Onoyom


    This study sought to investigate western and traditional educational background of midwives with regard to their effectiveness in delivery pain control in Cross River State-Nigeria. To achieve this purpose, two null hypotheses were formulated to guide the investigation. The study adopted the survey design. The sample consisted of 360 post-natal…

  7. Investigation of the Effects of Facility Background Pressure on the Performance and Voltage-Current Characteristics of the High Voltage Hall Accelerator (United States)

    Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Spektor, Rostislav


    The National Aeronautics and Space Administration (NASA) Science Mission Directorate In-Space Propulsion Technology office is sponsoring NASA Glenn Research Center to develop a 4 kW-class Hall thruster propulsion system for implementation in NASA science missions. A study was conducted to assess the impact of varying the facility background pressure on the High Voltage Hall Accelerator (HiVHAc) thruster performance and voltage-current characteristics. This present study evaluated the HiVHAc thruster performance in the lowest attainable background pressure condition at NASA GRC Vacuum Facility 5 to best simulate space-like conditions. Additional tests were performed at selected thruster operating conditions to investigate and elucidate the underlying physics that change during thruster operation at elevated facility background pressure. Tests were performed at background pressure conditions that are three and ten times higher than the lowest realized background pressure. Results indicated that the thruster discharge specific impulse and efficiency increased with elevated facility background pressure. The voltage-current profiles indicated a narrower stable operating region with increased background pressure. Experimental observations of the thruster operation indicated that increasing the facility background pressure shifted the ionization and acceleration zones upstream towards the thruster's anode. Future tests of the HiVHAc thruster are planned at background pressure conditions that are expected to be two to three times lower than what was achieved during this test campaign. These tests will not only assess the impact of reduced facility background pressure on thruster performance, voltage-current characteristics, and plume properties; but will also attempt to quantify the magnitude of the ionization and acceleration zones upstream shifting as a function of increased background pressure.

  8. One Language for the United States? (Un Idioma para Los Estados Unidos?) CSG Backgrounder. (United States)

    Ford, Mark L.

    The United States has become increasingly multilingual in recent decades, and while English is the most commonly spoken language, almost 11 percent of Americans prefer to speak another language at home. Bilingualism is promoted by governmental units at the federal, state, and local levels through a variety of programs, particularly in education…

  9. The current state of water resources of Transcarpathia

    Directory of Open Access Journals (Sweden)

    V. І. Nikolaichuk


    sanitary rules and regulations by the most of indicators of general health and specific indices. 19.0% of total water supply systems fail to meet the sanitary norms and regulations, in particular: 14.2% for the lack of sanitary protection zones; 1.9% because of unavailability of the necessary integrated treatment facilities, and 7.6% by the reason of absence of disinfecting plants. Possible ways of avoiding the depletion of water bodies are preventive water protection measures aimed at preventing or limiting pollution, water contamination and depletion; besides, it is necessary to educate people explaning them the current state and possible consequences of thoughtless water consumption.

  10. Ecopharmacovigilance: Current state, challenges, and opportunities in China

    Directory of Open Access Journals (Sweden)

    Jun Wang


    Full Text Available In a context of severe pharmaceutical pollution, "ecopharmacovigilance" (EPV has been an area of novel interest. It aims to ensure that significant environmental issues associated with pharmaceuticals in the environment are identified in a timely way, and managed appropriately. EPV has become a research hotspot as a comprehensive and boundary science in Europe and North America, and regulatory requirements governing the comprehensive environmental risk assessment (ERA of pharmaceuticals exist in these regions. A speedy Chinese pharmaceutical industry development and drug consumption, China should shoulder more international responsibility and contribute to the worldwide EPV. Compared to the west, EPV in China is in its infancy. We analyzed the current state of EPV-related practice in China and found that many efforts have been made by the Chinese government and specialists to control the ever-worsening environmental pharmaceutical pollution problems, including consummating related policies and regulations, revealing the occurrence and behavior of pharmaceutical residues in environment and developing new technologies to improve their removal performance. Besides, we posed some recommendations on appropriate EPV implementation that can be taken with China in future. These include, building perfect laws and regulation system on EPV, defining the evaluation index for EPV, continuing the clinical rational medication and the pharmaceutical take-back programs in China, popularizing the concept of EPV in China, and strengthening the policy-guided and scientific researches of EPV in pharmaceutical firms and academia.

  11. Ecopharmacovigilance: Current state, challenges, and opportunities in China. (United States)

    Wang, Jun; Hu, Xiamin


    In a context of severe pharmaceutical pollution, "ecopharmacovigilance" (EPV) has been an area of novel interest. It aims to ensure that significant environmental issues associated with pharmaceuticals in the environment are identified in a timely way, and managed appropriately. EPV has become a research hotspot as a comprehensive and boundary science in Europe and North America, and regulatory requirements governing the comprehensive environmental risk assessment (ERA) of pharmaceuticals exist in these regions. A speedy Chinese pharmaceutical industry development and drug consumption, China should shoulder more international responsibility and contribute to the worldwide EPV. Compared to the west, EPV in China is in its infancy. We analyzed the current state of EPV-related practice in China and found that many efforts have been made by the Chinese government and specialists to control the ever-worsening environmental pharmaceutical pollution problems, including consummating related policies and regulations, revealing the occurrence and behavior of pharmaceutical residues in environment and developing new technologies to improve their removal performance. Besides, we posed some recommendations on appropriate EPV implementation that can be taken with China in future. These include, building perfect laws and regulation system on EPV, defining the evaluation index for EPV, continuing the clinical rational medication and the pharmaceutical take-back programs in China, popularizing the concept of EPV in China, and strengthening the policy-guided and scientific researches of EPV in pharmaceutical firms and academia.

  12. Current State of Undergraduate Education in Oral Implantology in Japan. (United States)

    Homma, Shinya; Sasaki, Hotaka; Furuya, Yoshitaka; Ito, Taichi; Yajima, Yasutomo


    An anonymous questionnaire-based survey was used to determine the current state of and issues involved in undergraduate education in oral implantology at Tokyo Dental College. The participants comprised 139 students who had received lectures on and practical training in oral implantology in 2013. The results indicate that the overall level of student comprehension was high for both lectures and practical training content; the level of difficulty was appropriate for practical training, but the amount of practice time given requires reconsideration. Over 80% of the students gave positive responses in their overall evaluation of lectures and practical training, and the number of students who had an interest in oral implantology after finishing the course and who wanted to be involved in oral implantology as dentists increased. These results indicate that this undergraduate education program is effective in improving understanding of oral implantology. Improvement is required, however, in lecture methodology and practical training content. It is also suggested that the curriculum should be evaluated by students regularly and that the courses be subject to updating as required.

  13. Current state of the hydrothermal geochemistry studies at Cerro Prieto

    Energy Technology Data Exchange (ETDEWEB)

    Fausto L, J.J.; Jimenez S, M.E.; Esquer P, I.


    The current state of hydrothermal geochemistry studies being carried out at the field are reported. These studies are based on the results of chemical analysis of water samples collected during 1979 and 1980 at the geothermal wells of the area known as Cerro Prieto I, as well as from those located in the Cerro Prieto II and Cerro Prieto III areas, some of which have only recently started flowing. Data are presented on the chemical variations of the main chemical constituents dissolved in the waters, as well as on the Na/K and Na-K-Ca chemical relations and the temperatures calculated from them and from SiO/sub 2/. Fluid recharge into the reservoir and its direction of flow are interpreted from isotherm contour maps of the field prepared from Na/K and Na-K-Ca geothermometry and from concentration contour maps of some of the main chemical constituents. Well M-43 is discussed as an example of a well affected by well completion problems in its production casing. Its behavior is explained on the basis of the chemical characteristics of the produced water. The chemical changes that have taken place in some of the wells during production are explained by correlating the chemistry with the production mechanisms of the well (steam-water production rates).

  14. Ebola hemorrhagic Fever and the current state of vaccine development. (United States)

    Hong, Joo Eun; Hong, Kee-Jong; Choi, Woo Young; Lee, Won-Ja; Choi, Yeon Hwa; Jeong, Chung-Hyeon; Cho, Kwang-Il


    Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with Ebola Hemorrhagic Fever (EHF) was continuously increasing even though the any effective therapeutics or vaccines has not been developed yet. The Ebola virus in Guinea showed 98% homology with Zaire Ebola Virus. Study of the pathogenesis of Ebola virus infection and assess of the various candidates of vaccine have been tried for a long time, especially in United States and some European countries. Even though the attenuated live vaccine and DNA vaccine containing Ebola viral genes were tested and showed efficacy in chimpanzees, those candidates still need clinical tests requiring much longer time than the preclinical development to be approved for the practical treatment. It can be expected to eradicate Ebola virus by a safe and efficient vaccine development similar to the case of smallpox virus which was extinguished from the world by the variola vaccine.

  15. Current State of Agile User-Centered Design: A Survey (United States)

    Hussain, Zahid; Slany, Wolfgang; Holzinger, Andreas

    Agile software development methods are quite popular nowadays and are being adopted at an increasing rate in the industry every year. However, these methods are still lacking usability awareness in their development lifecycle, and the integration of usability/User-Centered Design (UCD) into agile methods is not adequately addressed. This paper presents the preliminary results of a recently conducted online survey regarding the current state of the integration of agile methods and usability/UCD. A world wide response of 92 practitioners was received. The results show that the majority of practitioners perceive that the integration of agile methods with usability/UCD has added value to their adopted processes and to their teams; has resulted in the improvement of usability and quality of the product developed; and has increased the satisfaction of the end-users of the product developed. The top most used HCI techniques are low-fidelity prototyping, conceptual designs, observational studies of users, usability expert evaluations, field studies, personas, rapid iterative testing, and laboratory usability testing.

  16. Current State of Value-Based Purchasing Programs. (United States)

    Chee, Tingyin T; Ryan, Andrew M; Wasfy, Jason H; Borden, William B


    The US healthcare system is rapidly moving toward rewarding value. Recent legislation, such as the Affordable Care Act and the Medicare Access and CHIP Reauthorization Act, solidified the role of value-based payment in Medicare. Many private insurers are following Medicare's lead. Much of the policy attention has been on programs such as accountable care organizations and bundled payments; yet, value-based purchasing (VBP) or pay-for-performance, defined as providers being paid fee-for-service with payment adjustments up or down based on value metrics, remains a core element of value payment in Medicare Access and CHIP Reauthorization Act and will likely remain so for the foreseeable future. This review article summarizes the current state of VBP programs and provides analysis of the strengths, weaknesses, and opportunities for the future. Multiple inpatient and outpatient VBP programs have been implemented and evaluated; the impact of those programs has been marginal. Opportunities to enhance the performance of VBP programs include improving the quality measurement science, strengthening both the size and design of incentives, reducing health disparities, establishing broad outcome measurement, choosing appropriate comparison targets, and determining the optimal role of VBP relative to alternative payment models. VBP programs will play a significant role in healthcare delivery for years to come, and they serve as an opportunity for providers to build the infrastructure needed for value-oriented care.

  17. Biodiesel production--current state of the art and challenges. (United States)

    Vasudevan, Palligarnai T; Briggs, Michael


    Biodiesel is a clean-burning fuel produced from grease, vegetable oils, or animal fats. Biodiesel is produced by transesterification of oils with short-chain alcohols or by the esterification of fatty acids. The transesterification reaction consists of transforming triglycerides into fatty acid alkyl esters, in the presence of an alcohol, such as methanol or ethanol, and a catalyst, such as an alkali or acid, with glycerol as a byproduct. Because of diminishing petroleum reserves and the deleterious environmental consequences of exhaust gases from petroleum diesel, biodiesel has attracted attention during the past few years as a renewable and environmentally friendly fuel. Since biodiesel is made entirely from vegetable oil or animal fats, it is renewable and biodegradable. The majority of biodiesel today is produced by alkali-catalyzed transesterification with methanol, which results in a relatively short reaction time. However, the vegetable oil and alcohol must be substantially anhydrous and have a low free fatty acid content, because the presence of water or free fatty acid or both promotes soap formation. In this article, we examine different biodiesel sources (edible and nonedible), virgin oil versus waste oil, algae-based biodiesel that is gaining increasing importance, role of different catalysts including enzyme catalysts, and the current state-of-the-art in biodiesel production.

  18. Electronic money in russia: current state and problems of development

    Directory of Open Access Journals (Sweden)

    T. G. Bondarenko


    Full Text Available Article is devoted to urgent problems of non-cash methods of calculation development by using electronic money – as one of the modern economically developed state strategic tasks. On modern economic science strong influence appears informatization process. The control expansion tendency, influence and distribution of commerce due to informatization of society led to emergence of the new phenomenon – information economy. Information economy brought new economic events which owing to their novelty are insufficiently studied to life. It is possible to carry electronic money to such phenomena of modern network economy Relevance and, in our opinion, timeliness of this scientific work, consisting in novelty of this non-cash payment method, its prospects and innovation within non-cash methods of calculations. Authors set as the purpose – studying of problems and the prospects of development of electronic money in the Russian Federation. In article theoretical bases of electronic money functioning are described. Determinations and classifications dismissed non-cash a method, and also the principles of electronic money functioning are considered, the questions of their historical development are raised.Authors analyzed statistical data on development of electronic services and channels of their using. Features, benefits and shortcomings of the current state of the market of electronic money are studied. The emphasis on that fact that in modern conditions considerable number of economic actors perform the activities, both in the real environment of economy, and within the virtual environment that promotes expansion of methods of their customer interaction by means of technical devices of personal computers, mobile phones is placed. In article common problems and tendencies of payments with using an electronic money are designated, the research on assessment of the current state and the prospects of electronic money

  19. Effect of scanner acoustic background noise on strict resting-state fMRI

    Directory of Open Access Journals (Sweden)

    C. Rondinoni


    Full Text Available Functional MRI (fMRI resting-state experiments are aimed at identifying brain networks that support basal brain function. Although most investigators consider a ‘resting-state' fMRI experiment with no specific external stimulation, subjects are unavoidably under heavy acoustic noise produced by the equipment. In the present study, we evaluated the influence of auditory input on the resting-state networks (RSNs. Twenty-two healthy subjects were scanned using two similar echo-planar imaging sequences in the same 3T MRI scanner: a default pulse sequence and a reduced “silent” pulse sequence. Experimental sessions consisted of two consecutive 7-min runs with noise conditions (default or silent counterbalanced across subjects. A self-organizing group independent component analysis was applied to fMRI data in order to recognize the RSNs. The insula, left middle frontal gyrus and right precentral and left inferior parietal lobules showed significant differences in the voxel-wise comparison between RSNs depending on noise condition. In the presence of low-level noise, these areas Granger-cause oscillations in RSNs with cognitive implications (dorsal attention and entorhinal, while during high noise acquisition, these connectivities are reduced or inverted. Applying low noise MR acquisitions in research may allow the detection of subtle differences of the RSNs, with implications in experimental planning for resting-state studies, data analysis, and ergonomic factors.

  20. NOAA Historical Tidal Current Data for the Coastal United States (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Knowledge of the timing and strength of tidal currents is extremely important for safe navigation in coastal waters. Tidal currents are almost always the strongest...

  1. NOAA Tidal Current Data for the Coastal United States (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Knowledge of the timing and strength of tidal currents is extremely important for safe navigation in coastal waters. Tidal currents are almost always the strongest...

  2. Current state of forest mapping with Landsat data in Siberia (United States)

    Maksyutov, Shamil; Sedykh, Vladimir; Kuzmenko, Ekaterina; Farber, Sergey; Kalinicheva, Svetlana; Fedorov, Alexander; Schepaschenko, Dmitry


    We review a current state of a forest type mapping with Landsat data in Siberia. Target algorithm should be based on dynamic vegetation approach to be applicable to the analysis of the forest type distribution for Siberia, aiming at capability of mapping Siberian forest landscapes for applications such as predicting response of forest composition to climate change. We present data for several areas in West Siberian middle taiga, Central Siberia and East Siberia near Yakutsk. Analysis of the field survey, forest inventory data was made to produce forest type classification accounting for several stages for forest succession and variations in habitats and landforms. Supervised classification was applied to the areas were the ground truth and inventory data are available, including several limited area maps and vegetation survey transects. In Laryegan basin in West Siberia the upland forest areas are dominated by mix of Scots pine on sandy soils and Siberian pine with presence of fir and spruce on the others. Abundance of Scots pine decreases to the west due to change in soils. Those types are separable using Landsat spectral data. In the permafrost area around Yakutsk the most widespread succession type is birch to larch. Three stages of the birch to larch succession are detectable from Landsat image. When Landsat data is used in both West and East Siberia, distinction between deciduous broad-leaved species (birch, aspen, and willow) is generally difficult. Similar problem exist for distinguishing between dark coniferous species (Siberian pine, fir and spruce). Image classification can be improved by applying landform type analysis, such as separation into floodplain, terrace, sloping hills. Additional layers of information can be a promising way to complement Landsat data.

  3. Cardiovascular pharmacogenomics; state of current knowledge and implementation in practice. (United States)

    Shahabi, Payman; Dubé, Marie-Pierre


    Pharmacogenomics (PGx) is the science that examines how an individual's genetic make-up affects the safety and efficacy of therapeutic drugs. PGx of response to cardiovascular (CV) medications is of the most successfully translated branches of PGx into the clinical workout. However, the clinical implementation of PGx of CV drugs is yet far beyond the growth of our understanding of the role of genetics in drug therapy. A considerable amount of efforts have been devoted by the regulatory agents like the food and drug administration (FDA) as well as the expert-based networks such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) to overcome the existing barriers. This has been done, at least in part, for some of the most widely prescribed CV drugs, including clopidogrel, warfarin and simvastatin for which the PGx knowledge have been satisfactorily robust to provoke the CPIC to issue the guidelines for these drugs and the FDA to update the drugs' labeling, both strongly recommended the use of genotype-guided dosing for these medications, provided that the genetic data are available. For other drugs, however, studies have produced contradictory results and further large and well-designed clinical trials are required to expand and confirm the clinical utility of their PGx data. This review paper presents the current state of knowledge in the field of PGx of CV medications and describes the facilities assisting to the translation of PGx data into the clinical practice. Afterward, the existing body of PGx literature of the most-commonly used CV medications is comprehensively discussed.

  4. Push Factor in Mexican Migration to the United States: The Background to Migration. (United States)


    Woids adDcus Amalysis. 17o. De&CrpCfts agricultural economics, economic analysis, employment, ethnic groups, foreign.government, labor, manpower...mobility,. national government, population migration, rural areas, socioeGronomic status, surveys, unskilled workers, urban areasI 17LIdasUeu/O~a.add Tam...States; (2) the Mixteca Baja, an extremely poor region of Oaxaca , which represents the lowest level of the rural socioeconomic development in Mexico

  5. Japan’s Political Turmoil in 2008: Background and Implications for the United States (United States)


    then- Prime Minister Shinzo Abe tried to deepen Japan’s alliance with the United States. They also touted a “values-based diplomacy” that called for...chambers are controlled by different parties. Shortly after the DPJ’s victory, then-prime minister Shinzo Abe resigned, leading the LDP to select...based system, Koizumi used his personal popularity and aggressiveness to enforce party discipline. However, his successors, Abe and Fukuda, often were

  6. Onchocerciasis in Plateau State; Nigeria: ecological background, local disease perception & treatment; and vector/parasite dynamics. (United States)

    Nwoke, B E; Onwuliri, C O; Ufomadu, G O


    The physico-biological ecological complex in Plateau State has by definition increased the potential of most rivers to support the breeding and dispersal of vector species as well as human acquisition and dissemination of the disease for several months in a year. Though villagers in endemic areas are of the know of the nuisance of blackfly bites, but the majority of them lacked the aetiological knowledge of onchocercal lesion. Hence disease management is misdirected towards consulting the oracle and appeasing the gods. The vectors of onchocerciasis in Plateau State, S. damnosum, and S. sirbanum are wet season breeders with their peak biting density occurring at the height of rainy season. However, biting flies carry more infective parasites at the beginning and end of rain. These vectors exhibit bimodal biting activity: a small one in the morning hours and a pronounced evening peak. Biting activity is at least influenced by two major climatic factors; illumination and temperature. However, the fastest changing climatic factor relative to an increase in the biting activity of flies was illumination. Microfilarial load in the skin of patients does not significantly change throughout the year or when biopsies are taken under shade throughout the day. Extreme temperatures, however, have significant reducing effect on the skin microfilarial. The epidemiological relevance of these in the ongoing MECTIZAN delivery in the State are discussed.

  7. Current state and future prospects for psychosomatic medicine in Japan. (United States)

    Murakami, Masato; Nakai, Yoshihide


    In this article, we describe the history and current state of psychosomatic medicine (PSM) in Japan and propose measures that could be considered based on our view of the future prospects of PSM in Japan. The Japanese Society of PSM (JSPM) was established in 1959, and the first Department of Psychosomatic Internal Medicine in Japan was established at Kyushu University In 1963. PSM in Japan has shown a prominent, unique development, with 3,300 members (as of March 2016), comprised of 71.6% of medical doctors including psychosomatic internal medicine (PIM) specialists, general internists, psychiatrists, pediatricians, obstetricians and gynecologists, dentists, dermatologists, and others. Most of the non-physician members include psychology and nursing staff specialists. The Japanese Society of Psychosomatic Internal Medicine (JSPIM), founded in 1996, is another major society with more than 1,200 physicians that is mainly composed of internists. The first joint congress of the five major PSM societies from each field was held in 2009. They included the Japanese Society of Psychosomatic Medicine, Psychosomatic Obstetrics and Gynecology, Psychosomatic Pediatric Medicine, Psychosomatic Dental Medicine, and Psychosomatic Internal Medicine. Several subdivided societies in related medical fields have also been established for cardiovascular, digestive, dermatological, and oriental medicine and for eating disorders, pain, fibromyalgia, stress science, behavioral medicine, and psycho-oncology. JSPM and JSPIM participate in international activities including publishing BioPsychoSocial Medicine (BPSM) and the establishment of a sister society relationship with the Germany College of PSM. PSM in Japan has adopted a variety of professional psychotherapies, including transactional analysis, autogenic therapy, and cognitive behavioral therapy. Mutual interrelationship has been promoted by the Japanese Union of Associations for Psycho-medical Therapy (UPM). Although PSM in Japan is

  8. Analysis on background magnetic field to generate eddy current by pulsed gradient of permanent-magnet MRI

    Institute of Scientific and Technical Information of China (English)


    In this paper the analytical expressions for the magnetic field H and induction B in iron-pole plates generated by MRI gradient coil are given using line-current and the multilayer dielectric plate model with the mirror-image method.Eddy current emanates from the magnetic flux in the iron-pole plates.In order to fully suppress the eddy current,this magnetic flux should be fully eliminated.The research results indicate the magnetic permeability of the resist-eddy plate must be bigger than that of magnetic pole material,i.e.pure iron,and that the resist-eddy plate should be thick enough to be far away from its magnetic saturation.

  9. Cadmium background concentrations to establish reference quality values for soils of São Paulo State, Brazil. (United States)

    de Oliveira, Vinicius Henrique; de Abreu, Cleide Aparecida; Coelho, Ricardo Marques; Melo, Leônidas Carrijo Azevedo


    Proper assessment of soil cadmium (Cd) concentrations is essential to establish legislative limits. The present study aimed to assess background Cd concentrations in soils from the state of São Paulo, Brazil, and to correlate such concentrations with several soil attributes. The topsoil samples (n = 191) were assessed for total Cd contents and for other metals using the USEPA 3051A method. The background concentration was determined according to the third quartile (75th). Principal component analysis, Spearman correlation, and multiple regressions between Cd contents and other soil attributes (pH, cation exchange capacity (CEC), clay content, sum of bases, organic matter, and total Fe, Al, Zn, and Pb levels) were performed. The mean Cd concentration of all 191 samples was 0.4 mg kg(-1), and the background concentration was 0.5 mg kg(-1). After the samples were grouped by parent material (rock origin) and soil type, the background Cd content varied, i.e., soils from igneous, metamorphic, and sedimentary rocks harbored 1.5, 0.4, and 0.2 mg kg(-1) of Cd, respectively. The background Cd content in Oxisols (0.8 mg kg(-1)) was higher than in Ultisols (0.3 mg kg(-1)). Multiple regression demonstrated that Fe was primarily attributed to the natural Cd contents in the soils (R (2) = 0.79). Instead of a single Cd background concentration value representing all São Paulo soils, we propose that the concentrations should be specific for at least Oxisols and Ultisols, which are the primary soil types.

  10. Lightning current parameters according to IEC 62305. Background, experience and outlook; Blitzstromparameter nach IEC 62305. Hintergrund, Erfahrung und Ausblick

    Energy Technology Data Exchange (ETDEWEB)

    Heidler, Fridolin [Universitaet der Bundeswehr Muenchen, Neubiberg (Germany). Inst. fuer Elektrische Energieversorgung


    Lightning protection measures are specified in the international standard series IEC 62305, which were integrated in European and German standards immediately upon publication in early 2006. The German version is the DIN EN 62 305 (VDE 0185-305). Investigations have shown that lightning currents present the biggest hazard. It is therefore the main danger at which all protective measures of the IEC 62305 standard series are aimed. The lightning current parameters to which the standards refer are based on long-term measurements carried out by Prof. Karl Berger on two telecommunication towers on San Salvatore mountain, Switzerland. (orig.)

  11. Accumulated Growing Degree Days, Contiguous United States, 1981 - Current Year (United States)

    U.S. Geological Survey, Department of the Interior — The USA National Phenology Network has available a series of gridded products enabling researchers to analyze current year Accumulated Growing Degree Days (AGDD)...

  12. Current state of the uranium extraction at the NMMC



    Currently of the uranium mined in NMMC is obtained by means of underground leaching in the Kyzyl-Kum open pits. This method allows to reduce the cost of uranium mining and ensure the environmentally clean production.

  13. Fault current limiter with solid-state circuit breakers (United States)

    Bălan, H.; Neamț, L.; Buzdugan, M. I.; Varodi, T.; Pop, E.


    Switching of power circuit breakers is an important technical issue, especially at short circuit, since the fault current cause thermal and dynamic stresses, and the power quality worsens. Recently, the development of distributed renewable electricity induces the short circuit protection problematic because the distributed production of electric energy cause the transport networks to lose their radial character and disturbs the protective relays coordination. The modern technologies for power switching uses static fault current limiters, which offers a viable solution to remove the problems caused by large fault currents in the system. An appropriate design of the current limiting device reduces the thermal and dynamic stress and limits the fault current to a low value. The static switches are based on high power semiconductor devices that offer advantages compared to mechanical switches. Using a fault current limiter that minimizes the effect of distributed generation of electricity in a radial network on the co-ordination of protective relays is a solution to this problem in terms of switching speed and lifespan of power switches.

  14. Current Developments in Communications Law in the United States (United States)

    Hadl, Robert D.


    Article reviews some of the major developments in communications law in the United States in the past year (1972). Significant events are covered in the areas of cable television, television programming and domestic satelites. (Author)

  15. Current State of the U.S. Ethanol Industry

    Energy Technology Data Exchange (ETDEWEB)

    Urbanchuk, John [Cardno ENTRIX, New Castle, DE (United States)


    The objective of this study is to provide a comprehensive overview of the state of the U.S. ethanol industry and to outline the major forces that will affect the development of the industry over the next decade.

  16. Engineering Ethics Education : Its Necessity, Objectives, Methods, Current State, and Challenges (United States)

    Fudano, Jun

    The importance of engineering ethics education has become widely recognized in the industrialized countries including Japan. This paper examines the background against which engineering ethics education is required, and reviews its objectives, methods, and challenges, as well as its current state. In pointing out important issues associated with the apparent acceptance and quantitative development of ethics education, especially after the establishment of the Japan Accreditation Board for Engineering Education in 1999, the author stresses that the most serious problem is the lack of common understanding on the objectives of engineering ethics education. As a strategy to improve the situation, the so-called “Ethics-across-the-Curriculum” approach is introduced. The author also claims that business/organization ethics which is consistent with engineering ethics should be promoted in Japan.

  17. Tri-State Current Source Inverter With Improved Dynamic Performance

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Loh, Poh Chiang; Wong, Chow Pang


    Traditional dc-ac current source inverter (CSI) has a right-half-plane (RHP) zero in its control-to-output transfer function. This RHP zero causes the inverter output to fall before rising when a step increase in command reference is required (commonly known as non-minimum-phase effect). To achieve...... sequence, the inductive boosting and discharging intervals can be decoupled, allowing the RHP zero to be eliminated with only minor circuit modifications (high level control schemes like predictive and multiloop voltage/current control remain unchanged). The designed inverter can be controlled using...

  18. HerMES: Current Cosmic Infrared Background Estimates are Consistent with Correlated Emission from Known Galaxies at z < 4

    CERN Document Server

    Viero, M P; Quadri, R F; Béthermin, M; Bock, J J; Burgarella, D; Chapman, S C; Clements, D L; Conley, A; Conversi, L; Duivenvoorden, S; Dunlop, J S; Farrah, D; Franceschini, A; Ivison, R J; Lagache, G; Magdis, G; Marchetti, L; Álvarez-Márquez, J; Marsden, G; Oliver, S J; Page, M J; Pérez-Fournon, I; Schulz, B; Scott, Douglas; Valtchanov, I; Vieira, J D; Wang, L; Wardlow, J; Zemcov, M


    We report contributions to cosmic infrared background (CIB) intensities originating from known galaxies, and their companions, at submillimeter wavelengths. Using the publicly-available UltraVISTA catalog, and maps at 250, 350, and 500 {\\mu}m from Herschel/SPIRE, we perform a novel measurement that exploits the fact that correlated sources will bias stacked flux densities if the resolution of the image is poor; i.e., we intentionally smooth the image - in effect degrading the angular resolution - before stacking and summing intensities. By smoothing the maps we are capturing the contribution of faint (undetected in K_S ~ 23.4) sources that are physically associated with the detected sources. We find that the cumulative CIB increases with increased smoothing, reaching 9.82 +- 0.78, 5.77 +- 0.43, and 2.32 +- 0.19 nWm^-2/sr at 250, 350, and 500 {\\mu}m at 300 arcsec full width half maximum. This corresponds to a fraction of the fiducial CIB of 0.94 +- 0.23, 1.07 +- 0.31, and 0.97 +- 0.26 at 250, 350, and 500 {\\mu...

  19. Methodological Approaches in Conducting Overviews: Current State in HTA Agencies (United States)

    Pieper, Dawid; Antoine, Sunya-Lee; Morfeld, Jana-Carina; Mathes, Tim; Eikermann, Michaela


    Objectives: Overviews search for reviews rather than for primary studies. They might have the potential to support decision making within a shorter time frame by reducing production time. We aimed to summarize available instructions for authors intending to conduct overviews as well as the currently applied methodology of overviews in…

  20. Robots in Education: The Current State of the Art. (United States)

    Lees, David; LePage, Pamela


    Describes how robots are currently being used in education as well as their future potential. Discusses limitations and effectiveness of robotics technology. Explores three ways robots are being used in the classroom: (1) to teach basic concepts; (2) to assist disabled students; and (3) as objects of study. Contains 60 references. (Author/AEF)

  1. State Child Support Agencies with Programs to Ensure Current Support Orders Reflect Current Earnings (United States)

    U.S. Department of Health & Human Services — Interactive Program Innovation Map - Click on State or Territory for information about child support agency programs designed to ensure that child support orders...

  2. History and Current Status of Divorce in the United States. (United States)

    Furstenberg, Frank F., Jr.


    Explores the remarkable shift in marriage and divorce practices that has occurred in the last third of this century in the United States. Information is presented on trends in this country and other industrialized nations, and some reasons for these changes are explored. (SLD)

  3. Current State and Development Trends for Integration Platforms

    Institute of Scientific and Technical Information of China (English)


    The integration platform (IP) is an advanced support tool for application softwa re development and integration. This paper analyzes the shortcomings of traditio nal software programming methods, introduces the background and development of i ntegration platforms and presents the basic functions and system architecture of computer integrated manufacture computing environment (CCE) IP as well as the i ntegration framework. Computer integrated manufacturing system (CIMS) applicatio n IP is defined i n relation to the IP requirements for CIMS implementation within a company. The CIMS application IP is not only a support tool for application software developm ent, but also a support tool for software integration and system operation. Ther efore, the behavior and functions of a CIMS application IP must also include sof tware integration and system operation. The development trend for CIMS applicati on IPs is discussed in view of software technology development trends.

  4. [Physiotherapeutic care marketing research: current state-of-the art]. (United States)

    Babaskin, D V


    Successful introduction of modern technologies into the national health care systems strongly depends on the current pharmaceutical market situation. The present article is focused on the peculiarities of marketing research with special reference to physiotherapeutic services and commodities. Analysis of the structure and sequence of marketing research processes is described along with the methods applied for the purpose including their support by the use of Internet resources and technologies.

  5. The Current State of Physics in Cuba: A Personal Perspective (United States)

    Alonso, Marcelo

    After 40 years of absence I returned twice to Cuba, in January and December of 2000, to participate as a guest lecturer in two international scientific meetings. The first dealt with physics education, and the second with current issues related to quantum mechanics. In addition to a few participants from Europe, the US and Latin America, the two meetings were well attended by Cuban physicists.

  6. OER and MOOCs in the Netherlands: current state of affairs


    Schuwer, R.; Janssen, B; Langhorst, T.


    In the fall of 2015 the Research Group Open Educational Resources of Fontys University of Applied Sciences - School of ICT has conducted a survey into the production and/or reuse of OER and MOOCs by Dutch publicly financed Higher Education (HE) institutions: 15 research universities, 38 university of applied sciences and 8 university medical centres. The goal of the survey was to provide an overview of the current situation regarding the creation, sharing and reuse of OER and MOOCs. Until the...

  7. The current state of FPGA technology in the nuclear domain

    Energy Technology Data Exchange (ETDEWEB)

    Ranta, J.


    Field programmable gate arrays are a form of programmable electronic device used in various applications including automation systems. In recent years, there has been a growing interest in the use of FPGA-based systems also for safety automation of nuclear power plants. The interest is driven by the need for reliable new alternatives to replace, on one hand, the aging technology currently in use and, on the other hand, microprocessor and software-based systems, which are seen as overly complex from the safety evaluation point of view. This report presents an overview of FPGA technology, including hardware aspects, the application development process, risks and advantages of the technology, and introduces some of the current systems. FPGAs contain an interesting combination of features from software-based and fully hardware-based systems. Application development has a great deal in common with software development, but the final product is a hardware component without the operating system and other platform functions on which software would execute. Currently the number of FPGA-based applications used for safety functions of nuclear power plants is rather limited, but it is growing. So far there is little experience or common solid understanding between different parties on how FPGAs should be evaluated and handled in the licensing process. (orig.)

  8. Birds of Pernambuco: Current state of ornithological knowledge

    Directory of Open Access Journals (Sweden)

    Gilmar Beserra de Farias


    Full Text Available An analysis of the present state of ornithological knowledge is required for the guidance of researchers in their future investigations. This work provides a survey of literature describing the development of ornithological research in the state. Between 1880 and 2008, many lists were organized, which contributed towards the systematization of the knowledge about Pernambuco’s birds. Out if the 535 species recorded, 49 are found in marine environments or wetlands, 450 occur in the Atlantic Rainforest, and 270 reside in the semi-arid Caatinga. We suggest that studies on the birds of the Caatinga are most important and should be prioritized at present, in addition to effective actions for the conservation of endemic species and of species under risk of extinction.

  9. Chairman’s government background, excess employment and government subsidies: Evidence from Chinese local state-owned enterprises

    Institute of Scientific and Technical Information of China (English)

    Xiongyuan; Wang; Shan; Wang


    Local state-owned enterprises(SOEs) in China continue to face government interference in their operations. They are influenced both by the government’s"grabbing hand" and by its "helping hand." Our study examines how SOE chairmen with connections to government influence their firm’s employment policies and the economic consequences of overstaffing. Using a sample of China’s listed local state-owned enterprises, we find that the scale of overstaffing in these SOEs is negatively related to the firms’ political connections to government. However,this relationship turns positive when the firm’s chairman has a government background. Appointing chairmen who have government backgrounds is a mechanism through which the government can intervene in local SOEs and influence firms’ staffing decisions. We also find that in compensation for the expenses of overstaffing, local SOEs receive more government subsidies and bank loans.However, the chairmen themselves do not get increased pay or promotion opportunities for supporting overstaffing. Further analysis indicates that whereas the "grabbing hand" of government does harm to a firm’s economic performance, the "helping hand" provides only weak positive effects, and such government intervention actually reduces the efficiency of social resource allocation.

  10. Invited review: Current state of genetic improvement in dairy sheep. (United States)

    Carta, A; Casu, Sara; Salaris, S


    Dairy sheep have been farmed traditionally in the Mediterranean basin in southern Europe, central Europe, eastern Europe, and in Near East countries. Currently, dairy sheep farming systems vary from extensive to intensive according to the economic relevance of the production chain and the specific environment and breed. Modern breeding programs were conceived in the 1960s. The most efficient selection scheme for local dairy sheep breeds is based on pyramidal management of the population with the breeders of nucleus flocks at the top, where pedigree and official milk recording, artificial insemination, controlled natural mating, and breeding value estimation are carried out to generate genetic progress. The genetic progress is then transferred to the commercial flocks through artificial insemination or natural-mating rams. Increasing milk yield is still the most profitable breeding objective for several breeds. Almost all milk is used for cheese production and, consequently, milk content traits are very important. Moreover, other traits are gaining interest for selection: machine milking ability and udder morphology, resistance to diseases (mastitis, internal parasites, scrapie), and traits related to the nutritional value of milk (fatty acid composition). Current breeding programs based on the traditional quantitative approach have achieved appreciable genetic gains for milk yield. In many cases, further selection goals such as milk composition, udder morphology, somatic cell count, and scrapie resistance have been implemented. However, the possibility of including other traits of selective interest is limited by high recording costs. Also, the organizational effort needed to apply the traditional quantitative approach limits the diffusion of current selection programs outside the European Mediterranean area. In this context, the application of selection schemes assisted by molecular information, to improve either traditional dairy traits or traits costly to record

  11. The current state of clinical interpretation of sequence variants. (United States)

    Hoskinson, Derick C; Dubuc, Adrian M; Mason-Suares, Heather


    Accurate and consistent variant classification is required for Precision Medicine. But clinical variant classification remains in its infancy. While recent guidelines put forth jointly by the American College of Medical Genetics and Genomics (ACMG) and Association of Molecular Pathology (AMP) for the classification of Mendelian variants has advanced the field, the degree of subjectivity allowed by these guidelines can still lead to inconsistent classification across clinical molecular genetic laboratories. In addition, there are currently no such guidelines for somatic cancer variants, only published institutional practices. Additional variant classification guidelines, including disease- or gene-specific criteria, along with inter-laboratory data sharing is critical for accurate and consistent variant interpretation.

  12. The Current State of Medical Malpractice in Urology. (United States)

    Sherer, Benjamin A; Coogan, Christopher L


    Medical malpractice can present an unwelcome professional, emotional, and economic burden to the practicing urologist. To date, there is a paucity of data specific to urologic malpractice in the literature. We performed a comprehensive literature search to identify and evaluate recent studies related to urologic malpractice. We also analyzed 6249 closed urologic claims from the largest available specialty-specific data set gathered by Physician Insurers Association of America from 1985 to 2012. The resulting comprehensive review seeks to raise awareness of current trends in the malpractice environment specific to urologic surgery while also helping urologists identify opportunities for risk management and improved patient care.

  13. Child Sleep Coaches: Current State and Future Directions. (United States)

    Mindell, Jodi A; Owens, Judith A; Babcock, Debra; Crabtree, Valerie McLaughlin; Ingram, David


    Given the genuine gaps in the availability of clinical sleep services for children, sleep coaching as a field has emerged and appears to be significantly increasing. Sleep coaches are typically individuals who provide individualized services, often via the Internet or phone, to families of infants and young children (and increasingly to older children, adolescents, and adults as well) with sleep problems. At this time, there is no universally accepted definition of sleep coach, nor are there clear guidelines regarding educational background, training requirements, scope of practice, or credentialing. To start to address the needs of families seeking the services of a sleep coach, educational materials were developed for parents and health care providers regarding issues to consider. Furthermore, there is a need going forward that (1) the designation sleep coach or consultant be clear and well defined, with a clear standard of care and scope of practice; (2) there is a standard core body of knowledge included in all training programs; (3) a certification process is developed for sleep coaches that is reputable and has recognizable and clear standards; and (4) that care for sleep problems in infants and young children are available to diverse populations, irrespective of socioeconomic status.

  14. Rural Administration in Romania: Evaluation of Current State



    A large part of Romania’s population lives in the rural environment, in communes and in their composing villages. However, there is an important gap in what concerns the administrative action, access to public services and the general development level, between the urban and the rural environment. The paper at hand aims at performing an assessment of the rural space state, from an administrative perspective, starting from the general characteristics of communes in Romania. This evaluation rep...

  15. E-learning: Current State of Art and Future Prospects

    Directory of Open Access Journals (Sweden)

    Mukta Goyal


    Full Text Available Adaptation of the E-learning system according to cognitive characteristics of the students is a relatively new direction of research on the conjunction of technical and pedagogical aspects. It is particularly important that the E-learning systems are able to integrate different paces of content and navigation in order to be able to respond to diverse needs of the students. The goal of this paper is to present the state of art in E-learning and thereafter to highlight some future aspects.

  16. Semantic Robot Vision Challenge: Current State and Future Directions

    CERN Document Server

    Helmer, Scott; Viswanathan, Pooja; McCann, Sancho; Dockrey, Matthew; Fazli, Pooyan; Southey, Tristram; Muja, Marius; Joya, Michael; Little, Jim; Lowe, David; Mackworth, Alan


    The Semantic Robot Vision Competition provided an excellent opportunity for our research lab to integrate our many ideas under one umbrella, inspiring both collaboration and new research. The task, visual search for an unknown object, is relevant to both the vision and robotics communities. Moreover, since the interplay of robotics and vision is sometimes ignored, the competition provides a venue to integrate two communities. In this paper, we outline a number of modifications to the competition to both improve the state-of-the-art and increase participation.

  17. Current state of knowledge about nutritional care of pregnant women

    Directory of Open Access Journals (Sweden)

    Luciana Barretto


    Full Text Available Pregnancy involves a significant anabolic activity that leads to increased nutritional needs relative to the preconception period. This paper aims to review the current understanding of the energy needs of macro and micronutrients during pregnancy as well as guidelines to address common gastrointestinal disorders during pregnancy, the issue of pica and anthropometric assessment to ensure an optimum weight gain. With the exception of iron, most of the nutrients needed by the pregnancy can be provided by a complete and balanced diet. Currently the scientific evidence shows that routine supplementation with iron and folic acid during pregnancy is a practice that prevents iron deficiency anemia, neural tube disorders and preterm births. Intermittent iron supplementation can also be an appropriated intervention. If the diet does not guarantee and adequate support, iodine, vitamin B12 and vitamin D supplements should also be necessaries. The anthropometric assessment by the pattern of weight gain should be present at each prenatal care visit to prevent maternal and fetal complications. In situations where the mother’s weight cannot be assessed, arm muscle circumference is possible to make an overall assessment as it correlates with maternal weight gain alternative. Measurements of biceps, triceps and subscapular skinfolds are another alternative that is useful to evaluate the fatty deposits and their location, in a complementary way to gain weight.

  18. The current state of facial prosthetics – A multicenter analysis. (United States)

    Thiele, Oliver C; Brom, Jörn; Dunsche, Anton; Ehrenfeld, Michael; Federspil, Philippe; Frerich, Bernhard; Hölzle, Frank; Klein, Martin; Kreppel, Matthias; Kübler, Alexander C; Kübler, Norbert R; Kunkel, Martin; Kuttenberger, Johannes; Lauer, Günter; Mayer, Boris; Mohr, Christopher; Neff, Andreas; Rasse, Michael; Reich, Rudolf H; Reinert, Siegmar; Rothamel, Daniel; Sader, Robert; Schliephake, Henning; Schmelzeisen, Rainer; Schramm, Alexander; Sieg, Peter; Terheyden, Hendrik; Wiltfang, Jörg; Ziegler, Christoph M; Mischkowski, Robert A; Zöller, Joachim E


    Even though modern surgical techniques are dominating reconstructive facial procedures, the capability to use facial epitheses for reconstruction is still an important skill for the maxillofacial surgeon. We present an international multicenter analysis to clarify which techniques are used to fixate facial prostheses. We contacted all maxillofacial departments in Germany, Austria, Switzerland and Norway which were registered with the German society for oral and maxillofacial surgery (DGMKG). These centers were asked via electronical mail to provide information on the type of epithesis fixation systems currently in use. The return rate from 58 departments was 43.1% (n = 25). Overall, implant fixation was the preferred fixation system (92%). Plates were the second most common fixation technique (32%). No centers reported the standard use of non-invasive fixation techniques for permanent epithesis fixation. The main retention systems in use were magnets (24/25), other retention systems are used much less often. The current preferred fixation technique for facial epitheses consists of implant-based, magnet-fixated epitheses. For nasal prostheses, a plate-based, magnet-fixated system is often used.

  19. Current state of herbicides in herbicide-resistant crops. (United States)

    Green, Jerry M


    Current herbicide and herbicide trait practices are changing in response to the rapid spread of glyphosate-resistant weeds. Growers urgently needed glyphosate when glyphosate-resistant crops became available because weeds were becoming widely resistant to most commonly used selective herbicides, making weed management too complex and time consuming for large farm operations. Glyphosate made weed management easy and efficient by controlling all emerged weeds at a wide range of application timings. However, the intensive use of glyphosate over wide areas and concomitant decline in the use of other herbicides led eventually to the widespread evolution of weeds resistant to glyphosate. Today, weeds that are resistant to glyphosate and other herbicide types are threatening current crop production practices. Unfortunately, all commercial herbicide modes of action are over 20 years old and have resistant weed problems. The severity of the problem has prompted the renewal of efforts to discover new weed management technologies. One technology will be a new generation of crops with resistance to glyphosate, glufosinate and other existing herbicide modes of action. Other technologies will include new chemical, biological, cultural and mechanical methods for weed management. From the onset of commercialization, growers must now preserve the utility of new technologies by integrating their use with other weed management technologies in diverse and sustainable systems.

  20. Imaging of HCC—Current State of the Art

    Directory of Open Access Journals (Sweden)

    Christina Schraml


    Full Text Available Early diagnosis of hepatocellular carcinoma (HCC is crucial for optimizing treatment outcome. Ongoing advances are being made in imaging of HCC regarding detection, grading, staging, and also treatment monitoring. This review gives an overview of the current international guidelines for diagnosing HCC and their discrepancies as well as critically summarizes the role of magnetic resonance imaging (MRI and computed tomography (CT techniques for imaging in HCC. The diagnostic performance of MRI with nonspecific and hepatobililiary contrast agents and the role of functional imaging with diffusion-weighted imaging will be discussed. On the other hand, CT as a fast, cheap and easily accessible imaging modality plays a major role in the clinical routine work-up of HCC. Technical advances in CT, such as dual energy CT and volume perfusion CT, are currently being explored for improving detection, characterization and staging of HCC with promising results. Cone beam CT can provide a three-dimensional analysis of the liver with tumor and vessel characterization comparable to cross-sectional imaging so that this technique is gaining an increasing role in the peri-procedural imaging of HCC treated with interventional techniques.

  1. [Video game and internet addiction. The current state of research]. (United States)

    Rehbein, F; Mößle, T; Arnaud, N; Rumpf, H-J


    The use of interactive screen media is widespread and for some users leads to pathological symptoms that are phenomenologically similar to signs of addictive disorders. Addictive use of computer games and other Internet applications, such as social media can be distinguished. In the past standard criteria to classify this new disorder were lacking. In DSM-5, nine criteria are proposed for diagnosing Internet gaming disorder. The focus is currently on video games as most studies have been done in this field. Prevalence estimations are difficult to interpret due to the lack of standard diagnostic measures and result in a range of the frequency of Internet addiction between 1 % and 4.2 % in the general German population. Rates are higher in younger individuals. For computer game addiction prevalence rates between 0.9 % and 1.7  % can be found in adolescents. Despite substantial comorbidity among those affected current research points to addictive media use as a stand-alone disorder.

  2. Poliomyelitis in the United States: A Historical Perspective and Current Vaccination Policy. (United States)

    Farizo, Karen M.; And Others


    Examines poliomyelitis in the United States by reviewing clinical manifestations and outcomes, history, recent epidemiologic characteristics, characteristics of currently available vaccines, controversies surrounding vaccination policy, current poliovirus vaccination recommendations, and prospects for worldwide eradication. Poliomyelitis remains…

  3. Current state of the art of vision based SLAM (United States)

    Muhammad, Naveed; Fofi, David; Ainouz, Samia


    The ability of a robot to localise itself and simultaneously build a map of its environment (Simultaneous Localisation and Mapping or SLAM) is a fundamental characteristic required for autonomous operation of the robot. Vision Sensors are very attractive for application in SLAM because of their rich sensory output and cost effectiveness. Different issues are involved in the problem of vision based SLAM and many different approaches exist in order to solve these issues. This paper gives a classification of state-of-the-art vision based SLAM techniques in terms of (i) imaging systems used for performing SLAM which include single cameras, stereo pairs, multiple camera rigs and catadioptric sensors, (ii) features extracted from the environment in order to perform SLAM which include point features and line/edge features, (iii) initialisation of landmarks which can either be delayed or undelayed, (iv) SLAM techniques used which include Extended Kalman Filtering, Particle Filtering, biologically inspired techniques like RatSLAM, and other techniques like Local Bundle Adjustment, and (v) use of wheel odometry information. The paper also presents the implementation and analysis of stereo pair based EKF SLAM for synthetic data. Results prove the technique to work successfully in the presence of considerable amounts of sensor noise. We believe that state of the art presented in the paper can serve as a basis for future research in the area of vision based SLAM. It will permit further research in the area to be carried out in an efficient and application specific way.

  4. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  5. Current regulations and state investment in the wind power projects

    Directory of Open Access Journals (Sweden)

    Danijela Simeunović


    Full Text Available It is the objective of this paper to present the path which the wind farm projects have undergone in Croatia from their introduction and expansion since the year 2007 up to the today's date when their development is temporarily stayed. The paper first describes the political and legal framework for renewable energy sources in Croatia, and specifically for wind power plants, as well as the current status of investment in building of wind farms in Croatia. The paper further analyses why the Croatian system of promotion of eligible producers has proven to attract investment, albeit unsustainable for a longer period of time, and which regulatory measures have later contributed to the suspension of wind farm investment in 2014. Legal and factual consequences of such suspension are discussed at the end of the paper, as well as some potential new business models for further exploitation of wind energy in Croatia.

  6. Minimally invasive veneers: current state of the art

    Directory of Open Access Journals (Sweden)

    Vanlıoğlu BA


    Full Text Available Burçin Akoğlu Vanlioğlu, Yasemin Kulak-Özkan University of Marmara, Department of Prosthetic Dentistry, Istanbul, TurkeyAbstract: Ceramic veneers are considered a conservative solution for patients requiring improvement of the shape, color, or position of their anterior teeth. Ceramic veneers have been extensively and successfully used to mask intrinsic staining, to give the appearance of straightening, and to correct minor malformations of anterior teeth without the removal of substantial amounts of sound tooth substance. The current literature was reviewed to search for the most important parameters determining the long-term success and correct application of ceramic veneers. Keywords: ceramic veneers, esthetic treatment

  7. Sediments Contamination with Organic Micropollutants: Current State and Perspectives (United States)

    Popenda, Agnieszka; Włodarczyk-Makuła, Maria


    This study focused on the sediment contamination with some organic micropollutants based on the monitoring data together with available literature in Poland. The following persistent organic pollutants (POPs): polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and chlorinated pesticides (CP) were characterized in sediments with respect to current legislations in force. Based on accessible data, higher PAHs, PCBs and CP concentrations were found in river sediments than in lake sediments. Especially, sediments of the Oder River and its tributary in the southern part of Poland, were highly polluted. In order to minimize the risk of the secondary pollution of surface waters, it is necessary to introduce consolidated management system with sediments proceeding. Furthermore, it is also of great importance to elaborate specific regulations concerning conditions of sediments management.

  8. Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge

    Directory of Open Access Journals (Sweden)

    Joana Martins


    Full Text Available Cyanobacteria are considered to be one of the most promising sources of new, natural products. Apart from non-ribosomal peptides and polyketides, ribosomally synthesized and post-translationally modified peptides (RiPPs are one of the leading groups of bioactive compounds produced by cyanobacteria. Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. It is assumed that the primary source of cyanobactins is cyanobacteria, although these compounds have also been isolated from marine animals such as ascidians, sponges and mollusks. The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential.

  9. Cyanobactins from Cyanobacteria: Current Genetic and Chemical State of Knowledge. (United States)

    Martins, Joana; Vasconcelos, Vitor


    Cyanobacteria are considered to be one of the most promising sources of new, natural products. Apart from non-ribosomal peptides and polyketides, ribosomally synthesized and post-translationally modified peptides (RiPPs) are one of the leading groups of bioactive compounds produced by cyanobacteria. Among these, cyanobactins have sparked attention due to their interesting bioactivities and for their potential to be prospective candidates in the development of drugs. It is assumed that the primary source of cyanobactins is cyanobacteria, although these compounds have also been isolated from marine animals such as ascidians, sponges and mollusks. The aim of this review is to update the current knowledge of cyanobactins, recognized as being produced by cyanobacteria, and to emphasize their genetic clusters and chemical structures as well as their bioactivities, ecological roles and biotechnological potential.


    Directory of Open Access Journals (Sweden)

    Laura Bokenchina


    Full Text Available The author researchers the social sphere consisting of the branches’ set creating various products in the form of non-material and material services which finally provide inquiries of the society in Kazakhstan that comes to be very important and authentic for the current matter of fact for this country. Transformations associated with the transition to the market economy caused a sharp decline in the rural population of life quality. In the context of transformational recession social services in the rural areas for a long time operated on prevailing conditions in the planned economy assets, resulting in the quality of its services significantly decreased.At the same time, the social sphere of urban economy is largely felt the benefits of the economic growth and participation in the reconstruction of this sector and took the largest system of corporation, especially in the status of city-companies within the social responsibility of business and regional agreements of social partnership.

  11. Computer-assisted Orthopaedic Surgery: Current State and Future Perspective

    Directory of Open Access Journals (Sweden)

    Guoyan eZheng


    Full Text Available Introduced about two decades ago, computer-assisted orthopaedic surgery (CAOS has emerged as a new and independent area, due to the importance of treatment of musculoskeletal diseases in orthopaedics and traumatology, increasing availability of different imaging modalities, and advances in analytics and navigation tools. The aim of this paper is to present the basic elements of CAOS devices and to review state-of-the-art examples of different imaging modalities used to create the virtual representations, of different position tracking devices for navigation systems, of different surgical robots, of different methods for registration and referencing, and of CAOS modules that have been realized for different surgical procedures. Future perspectives will also be outlined.

  12. Forest certification in Russia: development, current state and problems

    Directory of Open Access Journals (Sweden)

    Lukashevich Victor


    Full Text Available The article analyzes the development of voluntary forest certification by the Forest Stewardship Council (FSC system in Russia. The article is based on the review of diverse information sources, analysis of the reports of timber processing enterprises, personal observations during certification audits, discussions in workgroups, and information collected at training courses. We evaluated the present state of voluntary forest certification in Russia, analyzed non-compliances of the activity of Russian wood processing enterprises with the national standard FSC-STD-RUS-V6-1-2012 and indicated possible reasons for non-fulfillment of the requirements. We also presented problems in the development of forest certification in Russia and possible ways for its further development.

  13. Current state of studying precipitation acidification in Serbia

    Directory of Open Access Journals (Sweden)

    Talijan Radomir


    Full Text Available Basic relations between the state of air pollution and their effects on chemistry of precipitation were introduced in this paper. Changes in the composition of atmosphere were defined by numerous chemical elements and compounds different in character which also affect the phenomenon of acidification and alkaline processes. The interconnected sources of emission, relations between urban and rural, the regime of rainmeasuring system and climate elements combined as whole give us more complete image of the global phenomenon and its effects on cities as a contemporary social development first of all caused by industrialization, its dependance upon fosil sources of energy and demographic pressure. Characteristics of main pollutants were considered as well as their ability to modify atmospheric conditions, but also the influence of climate elements on those conditions, ph rainfall average value movement, seasonal and daily variations, the influence of industrial zones and agglomeration on the conditions in the area much wider than emitters.

  14. Current state of epidemiological studies in Belarus about Chernobyl sufferers

    Energy Technology Data Exchange (ETDEWEB)

    Matsko, V.P. [Institute of Radiobiology, Academy Sciences of Belarus, Minsk (Belarus)


    The present paper is an analysis of the results of epidemiological studies in Belarus about the after-effects of the accident at the Chernobyl atomic power station (ChAPS), based on published data at scientific institutes, organs and institutions of Ministry of Health. In the last years the affected population showed thereby more significant - as compared with republican indices - growth of incidence in the majority of diseases (first of all: digestion, urogenital, nervous, endocrine systems, diseases of ear, throat, nose both among adults and among children). Aggravation of health state continues in the participants of liquidation of the ChAPS accident consequences and the evacuees from the alienation zone which have obtained considerable radiation load to organism (rise of incidence of diseases of endocrine, cardiovascular, nervous system etc.). Considerable growth of thyroid cancer incidence is registered in Belarus children and adolescents, especially in the Gomel and Brest regions. This is conditioned by dose commitments on thyroid gland due to iodine radionuclides in first period after the accident, incorrect iodine prophylaxy, and goitre endemic. The rise of hereditary pathology is registered too. An expressed increase of oncological diseases is observed therewith mainly in the Gomel region, especially in the districts with high level of radiocontamination and, consequently, significant radiation load. First of all, this relates to the growth of incidence of cancer of lungs, mammary gland, bladder. The analysis of epidemiological studies performed in Belarus after the ChAPS catastrophe and comparison of them with data obtained in the pre-Chernobyl period testify to the aggravation of health state of Belarus population. The specialists unambiguously recognize the direct influence of radioactive pollution in the environment on rise of thyroid pathologies, hereditary and congenial diseases, and cancers of different localizations. There is no unique opinion

  15. Precarious Employment in the Vologda Oblast: Current State and Trends

    Directory of Open Access Journals (Sweden)

    Aleksandr Mikhailovich Panov


    Full Text Available The paper is devoted to the study of the phenomenon of precarious employment in Russian regions. Today, the socio-economic sciences lack a single concept of precarious employment applicable to Russian conditions. Despite the considerable amount of scientific and practical works of domestic and foreign authors on the issue of precarious employment, the criteria of its statistical evaluation as applied to Russian conditions have not been determined. At the same time, the development of precarious employment threatens the country’s socio-economic welfare, because it creates the risk of unwanted effects such as poor employment, hidden and open unemployment, lower labor productivity, degradation of human capital, etc. The paper provides a brief review of research on the problem stated, and defines precarious employment. The author makes an attempt to determine and substantiate the list of indicators available in official statistics for assessing precarious employment in the region. The study allocates three blocks of indicators: indicators of institutional regulation, conditions of employment and functioning of the labor market. Based on these indicators, the author analyzes the status and trends of precarious work in the Vologda Oblast in the period from 2001 to 2015. In some cases, the author presents a comparative analysis of the data for the Russian Federation and Northwestern Federal District. The analysis has helped identify positive and negative changes in the field of precarious employment in the Vologda Oblast. In particular, the author identifies the following problems: an increase in the share of those employed in the informal sector, a relative increase in the number of the working poor, an almost three-fold growth of overdue debts on wages in comparable prices per worker. On the basis of this analysis, the author identifies the directions of the state policy that can help reduce precarious employment: development of information

  16. Current state of biomedical engineering; Biomedical Engineering ha ima

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, K. [Waseda Univ., Tokyo (Japan). School of Science and Engineering; Kanamori, T. [National Inst. of Materials and Chemical Research, Tsukuba (Japan)


    Medical science is divided into basic medical science and clinical medicine, and the technology of the medical treatment is established as their aggregate power. This concept can be compared with the presence of industrial engineering as a product of physical science and engineering. Basic medical science has come to be combined with science deeply as a result of the rise of recent molecular biology. As to clinical medicine, current highly advanced medical treatment can be said to be made up of scientific technology. Medical treatment can be considered to include prevention, diagnosis, remedy, and rehabilitation stages. It is closely connected with engineering in each stage. The methods of approaching medical science are elucidation of the functions of internal organs and tissue considering that a living body is a plant, and offering of new therapeutical means by applying chemical devices to a living body. The functions of artificial organs can e divided roughly into convection transport, mass transfer, structural members, and signal transfer from the viewpoint of chemical engineering. Medical treatment will be brought into close relation with scientific technology in the future. 10 refs., 3 figs., 2 tabs.

  17. Meditative analgesia: the current state of the field. (United States)

    Grant, Joshua A


    Since the first demonstrations that mindfulness-based therapies could have a positive influence on chronic pain patients, numerous studies have been conducted with healthy individuals in an attempt to understand meditative analgesia. This review focuses explicitly on experimental pain studies of meditation and attempts to draw preliminary conclusions based on the work completed in this new field over the past 6 years. Dividing meditative practices into the broad categories of focused attention (FA) and open monitoring (OM) techniques allowed several patterns to emerge. The majority of evidence for FA practices suggests they are not particularly effective in reducing pain. OM, on the other hand, seems to influence both sensory and affective pain ratings depending on the tradition or on whether the practitioners were meditating. The neural pattern underlying pain modulation during OM suggests meditators actively focus on the noxious stimulation while inhibiting other mental processes, consistent with descriptions of mindfulness. A preliminary model is presented for explaining the influence of mindfulness practice on pain. Finally, the potential analgesic effect of the currently unexplored technique of compassion meditation is discussed.

  18. Clinical pharmacology in Russia-historical development and current state. (United States)

    Zagorodnikova Goryachkina, Ksenia; Burbello, Aleksandra; Sychev, Dmitry; Frolov, Maxim; Kukes, Vladimir; Petrov, Vladimir


    Clinical pharmacology in Russia has long history and is currently active, but rather unrecognized internationally. It is governmentally approved as a teaching/scientific specialty since 1983 and as a medical specialty since 1997. Courses of clinical pharmacology are included in the undergraduate curricula in the 5th and/or 6th year of education at all medical schools in the Russian Federation. Postgraduate education includes initial specialization in internal medicine with further residency in clinical pharmacology. Governmental legislation recommends that every healthcare institution has either a department or a single position of clinical pharmacologist. Major routine duties include information about and monitoring of medication use, consultations in difficult clinical situations, pharmacogenetic counseling, therapeutic drug monitoring, pharmacovigilance, and participation in drug and therapeutics (formulary) committees. There are official experts in clinical pharmacology in Russia responsible for coordinating relevant legislative issues. The chief expert clinical pharmacologist represents the discipline directly at the Ministry of Health. Research in clinical pharmacology in Russia is extensive and variable, but only some of it is published internationally. Russia is a participant of international societies of clinical pharmacology and therapeutics and collaboration is actively ongoing. There are still certain problems related to the development of the discipline in Russia-some healthcare institutions do not see the need for clinical pharmacology. However, the number of clinical pharmacologists in Russia is increasing as well as their role in physicians' education, national healthcare, and research.

  19. Precision therapy for lymphoma--current state and future directions. (United States)

    Intlekofer, Andrew M; Younes, Anas


    Modern advances in genomics and cancer biology have produced an unprecedented body of knowledge regarding the molecular pathogenesis of lymphoma. The diverse histological subtypes of lymphoma are molecularly heterogeneous, and most likely arise from distinct oncogenic mechanisms. In parallel to these advances in lymphoma biology, several new classes of molecularly targeted agents have been developed with varying degrees of efficacy across the different types of lymphoma. In general, the development of new drugs for treating lymphoma has been mostly empiric, with a limited knowledge of the molecular target, its involvement in the disease, and the effect of the drug on the target. Thus, the variability observed in clinical responses likely results from underlying molecular heterogeneity. In the era of personalized medicine, the challenge for the treatment of patients with lymphoma will involve correctly matching a molecularly targeted therapy to the unique genetic and molecular composition of each individual lymphoma. In this Review, we discuss current and emerging biomarkers that can guide treatment decisions for patients with lymphoma, and explore the potential challenges and strategies for making biomarker-driven personalized medicine a reality in the cure and management of this disease.

  20. Diagnosis of myocarditis: Current state and future perspectives. (United States)

    Biesbroek, P Stefan; Beek, Aernout M; Germans, Tjeerd; Niessen, Hans W M; van Rossum, Albert C


    Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or a persisting viral infection. It is therefore crucial to detect the disease early in its course and prevent persisting inflammation that may lead to DCM and end-stage heart failure. Because of the highly variable clinical presentation, ranging from mild symptoms to severe heart failure, and the limited available diagnostic tools, the evaluation of patients with suspected myocarditis represents an important clinical dilemma in cardiology. New approaches for the diagnosis of myocarditis are needed in order to improve recognition, to help unravel its pathophysiology, and to develop new therapeutic strategies to treat the disease. In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up.

  1. Prostate biopsy strategies: current state of the art. (United States)

    Mian, Badar M


    Prostate-specific antigen testing and prostate biopsy have revolutionized our ability to detect prostate cancer at an early stage. The transrectal ultrasound-guided biopsy procedure has undergone a number of modifications over the past 10 years to meet our goal of early detection of cancer at a curable stage. Biopsy schemes have evolved from lesion-directed biopsies to systematic mapping of the peripheral zone of the prostate, which harbors almost all of the significant tumor foci. An increase in the number of biopsy cores from 6 to 10 (or 12) has resulted in a significant improvement in the detection of clinically localized cancer, without any appreciable increase in the number of indolent cancers. Current biopsy schemes also have enhanced our ability to determine the true prognostic value of pathologic lesions such as high-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation which have been associated with cancer detection in repeat biopsies. I discuss the rationale behind, and the outcomes of, various biopsy strategies. More than 15 years after PSA testing was popularized for early detection, a number of men are presenting for evaluation regarding repeat prostate biopsy for various clinical indications. The indications, biopsy scheme, and cancer detection rates for repeat prostate biopsy are discussed in detail.

  2. Metabolomics: current state and evolving methodologies and tools. (United States)

    Oldiges, Marco; Lütz, Stephan; Pflug, Simon; Schroer, Kirsten; Stein, Nadine; Wiendahl, Christiane


    In recent years, metabolomics developed to an accepted and valuable tool in life sciences. Substantial improvements of analytical hardware allow metabolomics to run routinely now. Data are successfully used to investigate genotype-phenotype relations of strains and mutants. Metabolomics facilitates metabolic engineering to optimise mircoorganisms for white biotechnology and spreads to the investigation of biotransformations and cell culture. Metabolomics serves not only as a source of qualitative but also quantitative data of intra-cellular metabolites essential for the model-based description of the metabolic network operating under in vivo conditions. To collect reliable metabolome data sets, culture and sampling conditions, as well as the cells' metabolic state, are crucial. Hence, application of biochemical engineering principles and method standardisation efforts become important. Together with the other more established omics technologies, metabolomics will strengthen its claim to contribute to the detailed understanding of the in vivo function of gene products, biochemical and regulatory networks and, even more ambitious, the mathematical description and simulation of the whole cell in the systems biology approach. This knowledge will allow the construction of designer organisms for process application using biotransformation and fermentative approaches making effective use of single enzymes, whole microbial and even higher cells.

  3. Current state of web accessibility of Malaysian ministries websites (United States)

    Ahmi, Aidi; Mohamad, Rosli


    Despite the fact that Malaysian public institutions have progressed considerably on website and portal usage, web accessibility has been reported as one of the issues deserves special attention. Consistent with the government moves to promote an effective use of web and portal, it is essential for the government institutions to ensure compliance with established standards and guidelines on web accessibility. This paper evaluates accessibility of 25 Malaysian ministries websites using automated tools i.e. WAVE and Achecker. Both tools are designed to objectively evaluate web accessibility in conformance with Web Content Accessibility Guidelines 2.0 (WCAG 2.0) and United States Rehabilitation Act 1973 (Section 508). The findings reported somewhat low compliance to web accessibility standard amongst the ministries. Further enhancement is needed in the aspect of input elements such as label and checkbox to be associated with text as well as image-related elements. This findings could be used as a mechanism for webmasters to locate and rectify errors pertaining to the web accessibility and to ensure equal access of the web information and services to all citizen.

  4. Patient and citizen participation in German health care--current state and future perspectives. (United States)

    Loh, Andreas; Simon, Daniela; Bieber, Christiane; Eich, Wolfgang; Härter, Martin


    Patient participation within the German healthcare system is described at three different levels: the macro level as active patient influence on the regulation of medical care, the meso level in terms of institutions enhancing patient information and counselling, and the micro level focusing on the actual treatment decision-making process in the medical encounter. The main focus of the present publication is on the health care system-specific influences on patient participation in medical decision-making and on the current state of research and implementation of shared decision-making in Germany. We describe institutions promoting patient involvement, their aims and initiatives as well as recent changes in German legislation. Against the background of German health politics' endorsement of patient participation the German Ministry of Health funded a research consortium with shared decision-making intervention projects in various disease areas. The present state of the intervention projects' results is outlined as well as subsequently funded transfer projects and future perspectives of research grants. Supported by health politics and the utilisation of scientific evidence shared decision-making's transfer into practice is considered to be relevant to the German health care system.

  5. Current state of the art of medical foods. (United States)

    Blum, Stephanie; Brito, Fernando


    Inflammatory bowel disease (IBD) is one of the five most prevalent gastrointestinal disease burdens in the US, with an overall health care cost of more than USD 1.7 billion. It commonly requires a lifetime of care, and accounts for more than 700,000 physician visits, 100,000 hospitalizations, and disability in 119,000 patients each year. IBD is a multifactorial disease and comprises genetic susceptibility, uncontrolled immune responses, and environmental factors which play a role in the pathogenesis and course of the disease. IBD patients are lifelong on medication, either for induction or maintenance therapy. Current treatment option (corticosteroids, immune suppressants, biologics), administered in mono- or combination therapy, are still unsatisfactory. Due to the nature of disease, 20-40% of patients relapse within the first 12 months. Although modern treatment algorithms have diminished the risk of surgery, the treatments harbor significant side effects, which impacts patients' quality of life. The role of nutrition in IBD has gathered high interest, especially in pediatric Crohn's disease, where studies have shown that exclusive enteral nutrition can induce remission in mild-to-moderate disease comparable to corticosteroids. Thus, gastroenterologists and patients become increasingly aware that specific nutritional interventions offered in addition to the standard of care are an appealing option for a safe long-term disease management. Such specific nutritional solutions should be based on scientific/clinical evidence and specifically designed to address the patients' distinct nutritional requirements. As per definition, these nutrition products fall under the regulatory framework of a Medical Food (Foods for Special Medical Purposes in Europe).

  6. Resistive current states in wide superconducting films in zero magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Dmitriev, V M [B Verkin Institute for Low Temperature Physics and Engineering, National Academy of Sciences of Ukraine, 61103 Kharkiv (Ukraine); Zolochevskii, I V [B Verkin Institute for Low Temperature Physics and Engineering, National Academy of Sciences of Ukraine, 61103 Kharkiv (Ukraine)


    The temperature dependence of the current-voltage characteristics of high-quality thin films of tin from 7 to 50 {mu}m thick are investigated in the absence of an external magnetic field. For the first time, we have experimentally observed phase slip centres (PSCs) and phase slip lines (PSLs) on the same superconducting tin film with known parameters in the temperature intervals corresponding to the mechanisms of their formation and existence. We have shown that the states of a wide film with increasing transport current appear in the following order: the superconducting state for current less than critical; the resistive vortex state for current more than critical, but less than maximum current for the uniform flux flow (instability current); the critical state due to the onset of instability of the steady pattern of viscous motion of the vortices; a vortex-free resistive state with PSLs for current more than instability current, but less than the upper critical current; and the normal state at a current higher than the upper critical current.

  7. Current Cigarette Smoking Among Adults - United States, 2005-2015. (United States)

    Jamal, Ahmed; King, Brian A; Neff, Linda J; Whitmill, Jennifer; Babb, Stephen D; Graffunder, Corinne M


    Tobacco use is the leading cause of preventable disease and death in the United States, and cigarettes are the most commonly used tobacco product among U.S. adults (1,2). To assess progress toward achieving the Healthy People 2020 target of reducing the proportion of U.S. adults who smoke cigarettes to ≤12.0% (objective TU1.1),* CDC assessed the most recent national estimates of cigarette smoking prevalence among adults aged ≥18 years using data from the 2015 National Health Interview Survey (NHIS). The proportion of U.S. adults who smoke cigarettes declined from 20.9% in 2005 to 15.1% in 2015, and the proportion of daily smokers declined from 16.9% to 11.4%. However, disparities in cigarette smoking persist. In 2015, prevalence of cigarette smoking was higher among adults who were male; were aged 25-44 years; were American Indian/Alaska Native; had a General Education Development certificate (GED); lived below the federal poverty level; lived in the Midwest; were insured through Medicaid or were uninsured; had a disability/limitation; were lesbian, gay, or bisexual; or who had serious psychological distress. Proven population-based interventions, including tobacco price increases, comprehensive smoke-free laws, anti-tobacco mass media campaigns, and barrier-free access to tobacco cessation counseling and medications, are critical to reducing cigarette smoking and smoking-related disease and death among U.S. adults, particularly among subpopulations with the highest smoking prevalences (3).

  8. Current State of the Art in High Brightness LEDs (United States)

    Craford, George


    LED's have been commercially available since the 1960's. For many years they were used primarily for indicator applications. The remarkable increase in materials technology and efficiency that has been achieved since the early 1990's for AlInGaP red and amber LEDs, and InGaN green and blue LEDs, has enabled the penetration of markets such as outdoor display, signaling, and automotive brake light and turn signal applications. White LEDs, which are either blue LEDs combined with a phosphor, or a combination of red, green, and blue LEDs, are being used in emerging applications such as cell phone flash, television backlights, projection, and automotive headlights. In addition, to efficiency improvements these applications have required the development of higher power packages and, in some of these applications which are etendue limited, higher luminance devices. High power devices are commercially available which are capable of 140 lumens output and have an efficacy of around 70 lm/W for white emission. New package and chip technologies have been demonstrated which have a luminance of 38 mega nits (Mcd/m^2), approximately 50% more luminance than that of an automotive headlamp halogen bulb (˜25 mega nits). The recent progress in materials technology, packaging, and chip technology makes it clear that LED's will become important for general illumination applications. The rate of LED penetration of this market will depend upon continued increases in performance and lower costs as well as better control of the white spectral emission. Efficiency, current density, and costs are closely linked because the cost in dollars/lumen is inversely proportional to how many lumens can be realized from each unit of device area for a given device type. Performance as high as 138 lm/W, and over 40% wall plug efficiency, has been reported for low power research devices and over 90 lm/W for high power research devices. It is clear that high power commercial products with performance in


    Energy Technology Data Exchange (ETDEWEB)

    D. Moeller and L. C. Sun


    In the latter half of 2005, the U.S. Environmental Protection Agency (USEPA) published a Proposed Rule (40 CFR Part 197) for establishing a dose rate standard for limiting radionuclide releases from the proposed Yucca Mountain high-level radioactive waste repository during the time period from 10{sup 4} to 10{sup 6} years after closure. The proposed standard was based on the difference in the estimated total dose rate from natural background in the Amargosa Valley and the ''average annual background radiation'' for the State of Colorado. As defined by the USEPA, ''natural background radiation consists of external exposures from cosmic and terrestrial sources, and internal exposures from indoor exposures to naturally-occurring radon''. On the basis of its assessments, the USEPA estimated that the difference in the dose rate in the two identified areas was 3.5 mSv y{sup -1}. The purpose of this review was to provide an independent evaluation and review of this estimate. One of the first observations was that, because site-specific dose rate measurements for the Amargosa Valley ''were not available'', the dose rates for various sources of natural background in that area, used by the USEPA in its assessment, were based on modifications of the average values for the State of Nevada. A second observation was that the conversion factor applied in estimating the dose rates due to exposures to indoor radon and its decay products was a factor of 2 higher than the currently accepted value. Further review revealed that site-specific data for many natural background sources in the Amargosa Valley were available. One particularly important observation was that about 91% of the residents of that area live in mobile homes which, due to their construction and design, have indoor radon concentrations comparable to, or less than, those outdoors. For that reason, alone, the USEPA estimate of the average dose rate for

  10. The Current State of Poison Control Centers in Pakistan and the Need for Capacity Building

    Directory of Open Access Journals (Sweden)

    Nadeem Khan


    Full Text Available Background: Chemical exposure is a major health problem globally. Poison control centers (PCCs play a leading role both in developed and developing countries in the prevention and control of poisonous chemical exposures. In this study, we aimed to assess the current state of PCCs in Pakistan and highlight capacity building needs in these centers. Methods: A cross-sectional survey of the two registered PCCs was done during August – December 2011. Necessary services of the PCCs were evaluated and the data were recorded on a predesigned checklist. Results: Both PCCs are affiliated to a tertiary care hospital. Clinical services to poisoned patients were available 24 hours a day / 7 days a week. Information on common local products was available to poison center staff. Both centers were involved in undergraduate and post graduate teaching. Telephone poison information service was not available in either of centers. There was a limited capacity for qualitative and analytical toxicology. Common antidotes were available. There were limited surveillance activities to capture toxic risks existing in the community and also a deficiency was observed in chemical disaster planning. Conclusion: PCCs in Pakistan need capacity building for specialized training in toxicology, toxicovigilance, chemical disaster planning, analytical laboratory tests and telephone service for consultation in poisoning cases.   How to cite this article: Khan NU, Mir MU, Khan UR, Khan AR, Ara J, Raja K, et al. The Current State of Poison Control Centers in Pakistan and the Need for Capacity Building. Asia Pac J Med Toxicol 2014;3:31-5.

  11. Tanzania: Background and Current Conditions (United States)


    movement of refugees. Societal violence against women and persons with albinism and women persisted. Female genital mutilation (FGM), especially of...Zanzibar /islands over 99% Muslim Literacy: Male, 77.5%; Female , 66.2% (2003) Under-5 Mortality: 165 deaths/1,000 live births HIV/AIDS adult...infection rate: 6.2% (2007) Life Expectancy, years at birth: Male, 50.5 Female , 53.5 (2009 est.) Sources: CIA World Factbook 2010. Tanzania

  12. Judges in the Formation of the Nation- State: Professional Experiences, Academic Background and Geographic Circulation of Members of the Supreme Courts of Brazil and the United States

    Directory of Open Access Journals (Sweden)

    Luciano Da Ros


    Full Text Available This article compares the career profiles of judges from the highest bodies of the Judiciary in Brazil and the United States of America, examining the biographies of all the ministros of the Supreme Court of Justice (Empire and of the Supreme Federal Tribunal (Republic in Brazil, and of all the justices of the Supreme Court of the United States, appointed until 2008 in both cases. Based on the sociology of political elites perspective, the article examines data concerning academic background, geographic circulation and the different professional experiences — legal, political and linked to the administration of the State’s coercive activity (police or military — lived through by future members of the Supreme Courts of Brazil and the United States so as to identify the types of individuals recommended to join the top bodies of the Judiciary in the two countries. In this sense, different State-building processes are identified on the basis of the examination of Brazilian and US judicial elites, suggesting a more fragmented and diverse trajectory in the case of US justices, and greater homogeneity and centralization in the case of their Brazilian counterparts.

  13. Ground-state entanglement in a three-spin transverse Ising model with energy current

    Institute of Scientific and Technical Information of China (English)

    Zhang Yong; Liu Dan; Long Gui-Lu


    The ground-state entanglement associated with a three-spin transverse Ising model is studied. By introducing an energy current into the system, a quantum phase transition to energy-current phase may be presented with the variation of external magnetic field; and the ground-state entanglement varies suddenly at the critical point of quantum phase transition. In our model, the introduction of energy current makes the entanglement between any two qubits become maximally robust.

  14. Current Control in ITER Steady State Plasmas With Neutral Beam Steering

    Energy Technology Data Exchange (ETDEWEB)

    R.V. Budny


    Predictions of quasi steady state DT plasmas in ITER are generated using the PTRANSP code. The plasma temperatures, densities, boundary shape, and total current (9 - 10 MA) anticipated for ITER steady state plasmas are specified. Current drive by negative ion neutral beam injection, lower-hybrid, and electron cyclotron resonance are calculated. Four modes of operation with different combinations of current drive are studied. For each mode, scans with the NNBI aimed at differing heights in the plasma are performed to study effects of current control on the q profile. The timeevolution of the currents and q are calculated to evaluate long duration transients. Quasi steady state, strongly reversed q profiles are predicted for some beam injection angles if the current drive and bootstrap currents are sufficiently large.

  15. 75 FR 7284 - NIOSH Current Intelligence Bulletin-Asbestos Fibers and Other Elongate Mineral Particles: State... (United States)


    ... HUMAN SERVICES Centers for Disease Control and Prevention NIOSH Current Intelligence Bulletin--Asbestos... available for public comment entitled ``NIOSH Current Intelligence Bulletin--Asbestos Fibers and Other..., ``NIOSH Current Intelligence Bulletin--Asbestos Fibers and Other Elongate Mineral Particles: State of...

  16. Mentoring and New Teacher Induction in the United States: A Review and Analysis of Current Practices (United States)

    Bullough, Robert V., Jr.


    In this article, current practices were reviewed in mentoring and induction across three large states--New York, Texas, and California--and one small state, Utah. Patterns and trends are described in the United States, program results and evolving views of mentoring are discussed, gaps in the research literature are identified, and the future of…

  17. Novel kinetic and background current selectivity in the even harmonic components of fourier transformed square-wave voltammograms of surface-confined azurin. (United States)

    Zhang, Jie; Guo, Si-Xuan; Bond, Alan M; Honeychurch, Michael J; Oldham, Keith B


    Fourier transform analysis of ramped square-wave voltammograms indicates the availability of a novel form of kinetic selectivity for surface-confined electron-transfer processes. Thus, for all the even harmonic components, quasi-reversible processes are sensitive to the surface coverage, the reversible potential, the electron-transfer rate constant (k(0')), and the electron-transfer coefficient (alpha), as well as to the amplitude (DeltaE) and frequency (f) of the square wave and dc scan rate. Additionally, it is insensitive to background capacitance current. In contrast, reversible processes and background currents are predicted to be absent from the even harmonics and only detectable in the odd harmonic components. The square-wave voltammetry of the surface-confined quasi-reversible azurin process azurin[Cu(II)] + e(-) right arrow over left arrow azurin[Cu(I)] at a paraffin-impregnated graphite electrode has been employed as a model system to test theoretical predictions. Most voltammetric characteristics of the even harmonic components obtained from the Fourier analysis are consistent with electrode kinetic values of k(0') = 90 s(-1) and alpha = 0.48, although some nonideality possibly due to kinetic dispersion also is apparent. Conditions also have been determined under which a readily generated waveform constructed from the Fourier series of sine waves produces voltammograms that are essentially indistinguishable from those predicted when an ideal square wave is employed.

  18. Current State Efforts in Gifted/Talented Education in the United States. (United States)

    Mitchell, Bruce


    A survey of 50 state departments of education revealed increased spending for gifted/talented education from 1976/77. Fourteen states reported certification requirements for teaching the gifted, and the problem most frequently identified was funding. The most common teaching topics related to creative thinking development, higher level thinking,…

  19. Voltage and Current Regulators Design of Power Converters in Islanded Microgrids based on State Feedback Decoupling

    DEFF Research Database (Denmark)

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel


    In stand-alone microgrids based on voltage source inverters state feedback coupling between the capacitor voltage and inductor current degrades significantly the dynamics performance of voltage and current regulators. The decoupling of the controlled states is proposed, considering the limitations...... introduced by system delays. Moreover, a proportional resonant voltage controller is designed according to Nyquist criterion taking into account application requirements. Experimental tests performed in compliance with the UPS standards verify the theoretical analysis....

  20. Charge Neutral Fermionic States and Current Oscillation in a Graphene-Superconductor Hybrid Structure (United States)

    Duan, Wenye; Wang, Wei; Zhang, Chao; Jin, Kuijuan; Ma, Zhongshui


    The proximity properties of edge currents in the vicinity of the interface between the graphene and superconductor in the presence of magnetic field are investigated. It is shown that the edge states introduced by Andreev reflection at the graphene-superconductor (G/S) interface give rise to the charge neutral states in all Landau levels. We note that in a topological insulator-superconductor (TI/S) hybrid structure, only N = 0 Landau level can support this type of charge neutral states. The different interface states of a G/S hybrid and a TI/S hybrid is due to that graphene consists of two distinct sublattices. The armchair edge consists of two inequivalent atoms. This gives rise to unique electronic properties of edge states when connected to a superconductor. A direct consequence of zero charge states in all Landau levels is that the current density approaches zero at interface. The proximity effect leads to quantum magnetic oscillation of the current density in the superconductor region. The interface current density can also be tuned with a finite interface potential. For sharp δ-type interface potential, the derivative of the wavefunction is discontinuous. As a result, we found that there is current density discontinuity at the interface. The step of the current discontinuity is proportional to the strength of the interface potential.

  1. Producing a background free data set for measurement of the charge current flux and day-night asymmetry at the Sudbury Neutrino Observatory

    CERN Document Server

    McCauley, N K


    The SNO detector is a 1 kilo-tonne heavy water Cerenkov detector designed to solve the solar neutrino problem. The detector is situated 2km underground in the INCO Ltd. Creighton mine near Sudbury, Ontario. The heavy water is observed by approximately 9500 photo-multiplier tubes (PMTs) to detect Cerenkov light generated by solar neutrino interactions. Using heavy water SNO can detect neutrinos in three different ways. In this thesis aspects of the charge current (a reaction sensitive to electron neutrinos only) and elastic scattering flux analysis are presented. Some models predict a difference in the detected neutrino rate between day and night. Measurement of this via the day-night asymmetry can help solve the solar neutrino problem. One of the principal problems for the solar neutrino analysis are the instrumental backgrounds; events caused by processes other than Cerenkov light. This thesis contains the descriptions of the backgrounds, the data selection cuts that have been designed to remove them and the...

  2. 78 FR 9929 - Current Traumatic Brain Injury State Implementation Partnership Grantees; Non-Competitive One... (United States)


    ...-Competitive One-Year Extension Funds for Current Traumatic Brain Injury (TBI) State Implementation Partnership... Traumatic Brain Injury Act of 2008 (Pub. L. 110- 206). Under this authority, the HRSA TBI Program is charged... HUMAN SERVICES Health Resources and Services Administration Current Traumatic Brain Injury......

  3. Magnetic-field-induced superconducting state in Zn nanowires driven in the normal state by an electric current. (United States)

    Chen, Yu; Snyder, S D; Goldman, A M


    Four-terminal resistance measurements have been carried out on Zn nanowires formed using electron-beam lithography. When driven resistive by current, these wires reenter the superconducting state upon application of small magnetic fields. The data are qualitatively different from those of previous experiments on superconducting nanowires, which revealed either negative magnetoresistance near T_{c} or high-magnetic-field-enhanced critical currents.

  4. The study of different attention states under different background music based on Event-Related potential analysis

    Directory of Open Access Journals (Sweden)

    Tang Yun


    Full Text Available This paper conducts the research on the attention sates based on ERP analysis when the subjects are under the quiet, flute and zither background music. The amplitude and latency of P300 are analyzed. The results show that there are greater P300 amplitudes and smaller P300 latencies of CZ, PZ, OZ and CP3 in music background than those in quiet background. The PCA and ICA achieve to select the effective data components and the head model is reconstructed. The active degree of brain areas are analyzed by using the source location methods. The result shows that the brain’s excitement is very obvious under the Bach's flute background. The study also indicates that some background music might help to improve the attention.

  5. User-Computer Interface Technology: An Assessment of the Current State of the Art (United States)


    a model of the current state of the world. A similar effort is underway at the Computing Research Laboratory at New Mexico S-’ State University. One...process by validating or modifying requirements. Rapid prototyping techniques * such as storyboarding offer relatively low cost approaches to bringing the...Research Laboratory, New Mexico State University. Bannon, Liam J. (1986). Issues in design: some notes. In D. A. Norman and S. W. Draper (Eds.), User

  6. Assessment of Energy Production Potential from Ocean Currents along the United States Coastline

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Kevin A. [Georgia Inst. of Technology, Atlanta, GA (United States)


    Increasing energy consumption and depleting reserves of fossil fuels have resulted in growing interest in alternative renewable energy from the ocean. Ocean currents are an alternative source of clean energy due to their inherent reliability, persistence and sustainability. General ocean circulations exist in the form of large rotating ocean gyres, and feature extremely rapid current flow in the western boundaries due to the Coriolis Effect. The Gulf Stream system is formed by the western boundary current of the North Atlantic Ocean that flows along the east coastline of the United States, and therefore is of particular interest as a potential energy resource for the United States.

  7. Limitations Of The Current State Space Modelling Approach In Multistage Machining Processes Due To Operation Variations (United States)

    Abellán-Nebot, J. V.; Liu, J.; Romero, F.


    The State Space modelling approach has been recently proposed as an engineering-driven technique for part quality prediction in Multistage Machining Processes (MMP). Current State Space models incorporate fixture and datum variations in the multi-stage variation propagation, without explicitly considering common operation variations such as machine-tool thermal distortions, cutting-tool wear, cutting-tool deflections, etc. This paper shows the limitations of the current State Space model through an experimental case study where the effect of the spindle thermal expansion, cutting-tool flank wear and locator errors are introduced. The paper also discusses the extension of the current State Space model to include operation variations and its potential benefits.

  8. High ion charge states in a high-current, short-pulse, vacuum ARC ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Anders, A.; Brown, I.; MacGill, R.; Dickinson, M. [Lawrence Berkeley National Lab., CA (United States)


    Ions of the cathode material are formed at vacuum arc cathode spots and extracted by a grid system. The ion charge states (typically 1-4) depend on the cathode material and only little on the discharge current as long as the current is low. Here the authors report on experiments with short pulses (several {mu}s) and high currents (several kA); this regime of operation is thus approaching a more vacuum spark-like regime. Mean ion charge states of up to 6.2 for tungsten and 3.7 for titanium have been measured, with the corresponding maximum charge states of up to 8+ and 6+, respectively. The results are discussed in terms of Saha calculations and freezing of the charge state distribution.

  9. Emission of β+ Particles Via Internal Pair Production in the 0+ – 0+ Transition of 90Zr: Historical Background and Current Applications in Nuclear Medicine Imaging

    Directory of Open Access Journals (Sweden)

    Marco D'Arienzo


    Full Text Available 90Y is traditionally considered as a pure β– emitter. However, the decay of this radionuclide has a minor branch to the 0+ first excited state of 90Zr at 1.76 MeV, that is followed by a β+/β– emission. This internal pair production has been largely studied in the past because it is generated by a rare electric monopole transition (E0 between the states 0+/0+ of 90Zr. The positronic emission has been recently exploited for nuclear medicine applications, i.e. positron emission tomography (PET acquisitions of 90Y-labelled radiopharmaceuticals, widely used as therapeutic agents in internal radiation therapy. To date, this topic is gaining increasing interest in the radiation dosimetry community, as the possibility of detecting β+ emissions from 90Y by PET scanners may pave the way for an accurate patient-specific dosimetry. This could lead to an explosion in scientific production in this field. In the present paper the historical background behind the study of the internal pair production of the 0+/0+ transition of 90Zr is presented along with most up to date measured branch ratio values. An overview of most recent studies that exploit β+ particles emitted from 90Y for PET acquisitions is also provided.

  10. Series transformer based diode-bridge-type solid state fault current limiter

    Institute of Scientific and Technical Information of China (English)



    We propose a novel series transformer based diode-bridge-type solid state fault current limiter (SSFCL). To control the fault current, a series RLC branch is connected to the secondary side of an isolation series transformer. Based on this RLC branch, two current limiting modes are created. In the first mode, R and C are bypassed via a paralleled power electronic switch (insulated-gate bipolar transistor, IGBT) and L remains connected to the secondary side of the transformer as a DC reactor. In the second mode, the series reactor impedance is not enough to limit the fault current. In this case, the fault current can be con-trolled by selecting a proper on-off duration of the parallel IGBT, across the series damping resistor (R) and capacitor, which inserts high impedance into the line to limit the fault current. Then, by controlling the magnitude of the DC reactor current, the fault current is reduced and the voltage of the point of common coupling (PCC) is kept at an acceptable level. In addition, in the new SSFCL, the series RC branch, connected in parallel with the IGBT, serves as a snubber circuit for decreasing the transient recovery voltage (TRV) of the IGBT during on-off states. Therefore, the power quality indices can be improved. The measure-ment results of a built prototype are presented to support the simulation and theoretical studies. The proposed SSFCL can limit the fault current without any delay and successfully smooth the fault current waveform.

  11. Minimal invasive single-site surgery in colorectal procedures: Current state of the art

    Directory of Open Access Journals (Sweden)

    Diana Michele


    Full Text Available Background: Minimally invasive single-site (MISS surgery has recently been applied to colorectal surgery. We aimed to assess the current state of the art and the adequacy of preliminary oncological results. Methods: We performed a systematic review of the literature using Pubmed, Medline, SCOPUS and Web of Science databases. Keywords used were "Single Port" or "Single-Incision" or "LaparoEndoscopic Single Site" or "SILS™" and "Colon" or "Colorectal" and "Surgery". Results: Twenty-nine articles on colorectal MISS surgery have been published from July 2008 to July 2010, presenting data on 149 patients. One study reported analgesic requirement. The final incision length ranged from 2.5 to 8 cm. Only two studies reported fascial incision length. There were two port site hernias in a series of 13 patients (15.38%. Two "fully laparoscopic" MISS procedures with preparation and achievement of the anastomosis completely intracorporeally are reported. Future site of ileostomy was used as the sole access for the procedures in three studies. Lymph node harvesting, resection margins and length of specimen were sufficient in oncological cases. Conclusions: MISS colorectal surgery is a challenging procedure that seems to be safe and feasible, but the existing clinical evidence is limited. In selected cases, and especially when an ileostomy is planned, colorectal surgery may be an ideal indication for MISS surgery leading to a no-scar surgery. Despite preliminary oncological results showing the feasibility of MISS surgery, we want to stress the need to standardize the technique and carefully evaluate its application in oncosurgery under ethical committee control.

  12. Dynamics of the current filament formation and its steady-state characteristics in chalcogenide based PCM (United States)

    Bogoslovskiy, Nikita; Tsendin, Konstantin


    In the phase-change memory (PCM) crystallization occurs in the high-current filament which forms during switching to the conductive state. In the present paper we conduct a numerical modeling of the current filament formation dynamics in thin chalcogenide films using an electronic-thermal model based on negative-U centers tunnel ionization and Joule heating. The key role of inhomogeneities in the filament formation process is shown. Steady-state filament parameters were obtained from the analysis of the stationary heat conduction equation. The filament formation dynamics and the steady-state filament radius and temperature could be controlled by material parameters and contact resistance. Consequently it is possible to control the size of the region wherein crystallization occurs. A good agreement with numerous experimental data leads to the conclusion that thermal effects play a significant role in CGS conduction and high-current filament formation while switching.

  13. Radar Time and a State-Space Based Approach To Quantum Field Theory In Gravitational and Electromagnetic Backgrounds

    CERN Document Server

    Dolby, C E; Dolby, Carl E.; Gull, Stephen F.


    In a recent paper (hep-th/0103228) a new initial value formulation of fermionic QFT was presented that is applicable to an arbitrary observer in any electromagnetic background. This approach suggests a consistent particle interpretation at all times, with the concept of `radar time' used to generalise this interpretation to an arbitrarily moving observer. In the present paper we extend this formalism to allow for gravitational backgrounds. The observer-dependent particle interpretation generalises Gibbons' definition to non-stationary spacetimes. This allows any observer to be considered, providing a particle interpretation that depends {\\it only} on the observer's motion and the background, not on any choice of coordinates or gauge, or on details of their particle detector. Consistency with known results is demonstrated for the cases of Rindler space and deSitter space. Radar time is also considered for an arbitrarily moving observer in an arbitrary 1+1 dimensional spacetime, and for a comoving observer in a...

  14. Including Alternative Resources in State Renewable Portfolio Standards: Current Design and Implementation Experience

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Bird, L.


    Currently, 29 states, the District of Columbia, and Puerto Rico have instituted a renewable portfolio standard (RPS). An RPS sets a minimum threshold for how much renewable energy must be generated in a given year. Each state policy is unique, varying in percentage targets, timetables, and eligible resources. This paper examines state experience with implementing renewable portfolio standards that include energy efficiency, thermal resources, and non-renewable energy and explores compliance experience, costs, and how states evaluate, measure, and verify energy efficiency and convert thermal energy. It aims to gain insights from the experience of states for possible federal clean energy policy as well as to share experience and lessons for state RPS implementation.

  15. Change of surface critical current in the surface superconductivity and mixed states of superconducting niobium (United States)

    Aburas, Muhamad; Pautrat, Alain; Bellido, Natalia


    A systematic study of irreversible magnetization was performed in bulk niobium after different surface treatments. Starting with smooth surfaces and abrading them, a strong increase of the critical current is observed up to an apparent limiting value. An impressive change of the critical current is also observed in the surface superconductivity (SSC) state, reaching values of the same order of magnitude as in the mixed state. We explain also the observation of strong SSC for magnetic fields perpendicular to large facets in terms of nucleation of superconductivity along bumps of a corrugated surface.

  16. High magnetic field science and its application in the United States current status and future directions

    CERN Document Server

    National Research Council of the National Academies


    The Committee to Assess the Current Status and Future Direction of High Magnetic Field Science in the United States was convened by the National Research Council in response to a request by the National Science Foundation. This report answers three questions: (1) What is the current state of high-field magnet science, engineering, and technology in the United States, and are there any conspicuous needs to be addressed? (2) What are the current science drivers and which scientific opportunities and challenges can be anticipated over the next ten years? (3) What are the principal existing and planned high magnetic field facilities outside of the United States, what roles have U.S. high field magnet development efforts played in developing those facilities, and what potentials exist for further international collaboration in this area? A magnetic field is produced by an electrical current in a metal coil. This current exerts an expansive force on the coil, and a magnetic field is "high" if it challenges the str...

  17. Nutrition support in the United States, what is the current practice?

    Institute of Scientific and Technical Information of China (English)

    Patricia S. Anthony


    Clinical nutrition in the United States encompasses a vast continuum of nutrition:from the process of identification of malnutition to the management and prevention of obesity. This presentation with focus on the current pratice of nutrition support in the United States. Nutrition support is the provision of specially formulated and/or delivered parenteral or enteral nutrients to maintain or restore optimal nutrition status.

  18. 2D phase tomography of biotissues: IV. Wavelet processing of phase tomograms of the background and precancerous endometrial states (United States)

    Peresunko, A. P.; Zavadovskya, I. G.


    The paper deals with the studying of prognostic possibilities of determining the orientation structure of endometrial strome in the normal state and hiperplasia. The laser diagnostic of endometrial state is based on the principles of optical changes of laser radiation during its passing through the histological sample with the following investigation of its wavelet coefficients.

  19. Two Paths to Inequality in Educational Outcomes: Family Background and Educational Selection in the United States and Norway (United States)

    Reisel, Liza


    The United States and Norway represent two distinctively different attempts to equalize educational opportunity. Whereas the United States has focused on expansion and the proliferation of lower-tier open-access institutions, Norway has emphasized institutional streamlining and the equalization of living conditions. At the same time, the two…

  20. The steady-state performance of a controlled current active filter

    Energy Technology Data Exchange (ETDEWEB)

    Duke, R.M. (Univ. of Canterbury, Christchurch (New Zealand). Dept. of Electrical and Electronic Engineering); Round, S.D. (Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Electrical Engineering)


    An active filter that uses a high-frequency D-class asynchronous switching inverter for power system current distortion compensation is described. The distortion compensation technique involves deriving a signal corresponding to the distortion component of load current, and inverting and amplifying this signal for addition back to the supply current to cancel the load current distortion. A synthetic sinusoid is used to determine the distortion component in the time domain. Extensive computed and experimental results, illustrating the system's steady-state performance and ability to reduce the current harmonic distortion components, are presented. An intelligent controller is proposed to maintain the active filter's performance at the optimal operating point under varying load conditions.

  1. Dynamical skyrmion state in a spin current nano-oscillator with perpendicular magnetic anisotropy. (United States)

    Liu, R H; Lim, W L; Urazhdin, S


    We study the spectral characteristics of spin current nano-oscillators based on the Pt/[Co/Ni] magnetic multilayer with perpendicular magnetic anisotropy. By varying the applied magnetic field and current, both localized and propagating spin wave modes of the oscillation are achieved. At small fields, we observe an abrupt onset of the modulation sidebands. We use micromagnetic simulations to identify this state as a dynamical magnetic skyrmion stabilized in the active device region by spin current injection, whose current-induced dynamics is accompanied by the gyrotropic motion of the core due to the skew deflection. Our results demonstrate a practical route for controllable skyrmion manipulation by spin current in magnetic thin films.

  2. The Study of the Role of the Background Languages in Third Language Acquisition. the State of the Art (United States)

    Falk, Ylva; Bardel, Camilla


    The aim of this article is to give an up-to-date picture of study of the role of the background languages (the first language, L1, and the second language, L2) in third language (L3) acquisition, mainly in the two areas of vocabulary and syntax. These seem to be the two linguistic levels on which there has so far been most research concerning…

  3. Early Childhood Inclusion in the United States: Goals, Current Status, and Future Directions (United States)

    Guralnick, Michael J.; Bruder, Mary Beth


    The current status and future directions of early childhood inclusion in the United States are discussed from the perspective of 4 key goals: access, accommodations and feasibility, developmental progress, and social integration. Recommendations are put forward to promote inclusion goals emphasizing administrative structures, personnel…

  4. The Current State of Research on Networks in China’s Business System

    NARCIS (Netherlands)

    J. Meuer (Johannes); B. Krug (Barbara)


    textabstractThe purpose of the paper is to assess the current state of network research in China’s business system. Research on networks has developed significantly during the last decades in regards to analytic techniques, number of research projects, and accumulated findings. While research on net

  5. Planning for Development in the Arab Gulf States: A content Analysis of Current Development Plans

    DEFF Research Database (Denmark)

    Hvidt, Martin


    Abstract: This paper analyses current development plans published by the GCC states (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in order to explore the region’s future growth trajectory: what barriers to growth are foreseen and how can they be anticipated; what...

  6. Globalization of Gerontology Education: Current Practices and Perceptions for Graduate Gerontology Education in the United States (United States)

    Mwangi, Samuel M.; Yamashita, Takashi; Ewen, Heidi H.; Manning, Lydia K.; Kunkel, Suzanne R.


    The purpose of this study is to document current practices and understandings about globalization of gerontology education in the United States. Better understanding of aging requires international perspectives in global communities. However, little is known about how globalization of gerontology education is practiced in U.S. graduate-level…

  7. Evaluation of current state of agricultural land using problem-oriented fuzzy indicators in GIS environment (United States)

    Current state of agricultural lands is defined under influence of processes in soil, plants and atmosphere and is described by observation data, complicated models and subjective opinion of experts. Problem-oriented indicators summarize this information in useful form for decision of the same specif...

  8. Tidal Stream Generators, current state and potential opportunities for condition monitoring

    DEFF Research Database (Denmark)

    Kappatos, Vassilios; Georgoulas, George; Avdelidis, Nicolas


    is being retarded by operation and maintenance problems, which results in very low operational availability times, as low as 25 %. This paper presents a literature review of the current state of tidal device operators as well as some commercial tidal turbine condition monitoring solutions. Furthermore...

  9. The Current State of Empirical Support for the Pharmacological Treatment of Selective Mutism (United States)

    Carlson, John S.; Mitchell, Angela D.; Segool, Natasha


    This article reviews the current state of evidence for the psychopharmacological treatment of children diagnosed with selective mutism within the context of its link to social anxiety disorder. An increased focus on potential medication treatment for this disorder has resulted from significant monetary and resource limitations in typical practice,…

  10. Current state and future directions of neurochemical biomarkers for Alzheimer's disease

    NARCIS (Netherlands)

    de Jong, Daniëlle; Kremer, Berry P H; Olde Rikkert, Marcel G M; Verbeek, Marcel M


    In this comprehensive review, we summarize the current state-of-the-art of neurochemical biomarkers for Alzheimer's disease. Predominantly, these biomarkers comprise cerebrospinal fluid biomarkers directly related to the pathophysiology of this disorder (such as amyloid beta protein, tau protein). W

  11. The current state of teaching specialized English for chemistry and improvements

    Institute of Scientific and Technical Information of China (English)

    Jin-Liang Zhuang


    The globalization of world economy makes the learning of Specialized English for Chemistry more and more important. In this paper, we have discussed the current state and problems of this cause. Finally, several suggestions have been brought to improve the teaching of this cause.

  12. "Nobody Told Us about What Happened": The Current State of Holocaust Education in Romania (United States)

    Misco, Tomas


    This research study sought to understand the current state of Holocaust education in Romanian classrooms and how sociocultural and institutional forces influence its treatment. By identifying the obstacles, challenges, and successes of Holocaust education in Romania, this study can both disseminate the techniques and conditions that bring about…

  13. Dominant male song performance reflects current immune state in a cooperatively breeding songbird

    NARCIS (Netherlands)

    York, Jenny E.; Radford, Andrew N.; Groothuis, Ton G.; Young, Andrew J.


    Conspicuous displays are thought to have evolved as signals of individual quality, though precisely what they encode remains a focus of debate. While high quality signals may be produced by high quality individuals due to good genes or favourable early-life conditions, whether current immune state a

  14. Current State of Environmental Education in Mexico: A Study on Practices, Audiences, Settings, and Topics (United States)

    Marcos-Iga, Jose; Shaw, William


    Environmental education in Mexico takes many forms and plays a wide variety of roles. Through an online survey, we addressed the need to present a wider picture on the current state of environmental education practices in Mexico: Who is engaging in environmental education practices, how important is it for their organization, who are they…


    Directory of Open Access Journals (Sweden)

    Ma Hang


    Full Text Available Oil and gas resources are the main energy resources consumed in the world, so the oil and gas industry has the economic and political aspects, profoundly inuencing the development of modern international economic and political relations.This article analyzes the current state of Russian-Chinese cooperation in the sphere of energy resources on the basis of statistical data on the volume of bilateral trade and energy compared with the data of other countries exporting energy resources. Also assessed the prospects for Russian-Chinese cooperation in the sphere of energy resources on the background of signicant world events and the Sino-Russian relations over the last few years (for example, the impact on the Russian-Chinese cooperation events such as rising US energy independence and solutions IMF to include the yuan in the basket SDR.

  16. Complex state variable- and disturbance observer-based current controllers for AC drives

    DEFF Research Database (Denmark)

    Dal, Mehmet; Teodorescu, Remus; Blaabjerg, Frede


    , extracted by a disturbance observer and then injected into the current controller. In this study, a revised version of a disturbance observer-based controller and a well known complex variable model-based design with a single set of complex pole are compared in terms of design aspects and performance...... of the parameter and the cross-coupling effect. Moreover, it provides a better performance, smooth and low noisy operation with respect to the complex variable controller....... of the stator current. In order to improve the current control performance an alternative current control strategy was proposed previously aiming to avoid the undesired cross-coupling and non-linearities between the state variables. These effects are assumed as disturbances arisen in the closed-loop path...

  17. Lower bounds for ballistic current and noise in non-equilibrium quantum steady states

    Directory of Open Access Journals (Sweden)

    Benjamin Doyon


    Full Text Available Let an infinite, homogeneous, many-body quantum system be unitarily evolved for a long time from a state where two halves are independently thermalized. One says that a non-equilibrium steady state emerges if there are nonzero steady currents in the central region. In particular, their presence is a signature of ballistic transport. We analyze the consequences of the current observable being a conserved density; near equilibrium this is known to give rise to linear wave propagation and a nonzero Drude peak. Using the Lieb–Robinson bound, we derive, under a certain regularity condition, a lower bound for the non-equilibrium steady-state current determined by equilibrium averages. This shows and quantifies the presence of ballistic transport far from equilibrium. The inequality suggests the definition of “nonlinear sound velocities”, which specialize to the sound velocity near equilibrium in non-integrable models, and “generalized sound velocities”, which encode generalized Gibbs thermalization in integrable models. These are bounded by the Lieb–Robinson velocity. The inequality also gives rise to a bound on the energy current noise in the case of pure energy transport. We show that the inequality is satisfied in many models where exact results are available, and that it is saturated at one-dimensional criticality.

  18. Interpreting current-induced spin polarization in topological insulator surface states (United States)

    Li, Pengke; Appelbaum, Ian


    Several recent experiments on three-dimensional topological insulators claim to observe a large charge current-induced nonequilibrium ensemble spin polarization of electrons in the helical surface state. We present a comprehensive criticism of such claims, using both theory and experiment: First, we clarify the interpretation of quantities extracted from these measurements by deriving standard expressions from a Boltzmann transport equation approach in the relaxation-time approximation at zero and finite temperature to emphasize our assertion that, despite high in-plane spin projection, obtainable current-induced ensemble spin polarization is minuscule. Second, we use a simple experiment to demonstrate that magnetic field-dependent open-circuit voltage hysteresis (identical to those attributed to current-induced spin polarization in topological insulator surface states) can be generated in analogous devices where current is driven through thin films of a topologically trivial metal. This result ipso facto discredits the naive interpretation of previous experiments with TIs, which were used to claim observation of helicity, i.e., spin-momentum locking in the topologically protected surface state.

  19. The Current Mental State of School Students in Online Learning Conditions

    Directory of Open Access Journals (Sweden)

    Kovalevskaya E.V.,


    Full Text Available This article discusses the results of a study of actual mental state of high school students who are active subjects of career self-determination in terms of interactive learning. There are four groups of methods of interactive training: psychological training, art therapy, cognitive, and game training. The main task, which is solved by a researcher in a formative experiment with the use of each of these methods, is to establish significant differences in health, activity and mood as the indicators of current mental state of students in the classroom. As a result, we found that the most significant improvements in the current mental state takes place when using art and game therapy, so these techniques should be used in groups of students with low motivation to work, as well as in the adverse psychological climate. Less significant was the improvement of the current mental state after psychological training due to the fact that this method allow to update and seek solutions to the most important intrapersonal issues and require the implementation of a deeper reflection

  20. Current driven tri-stable resistance states in magnetic point contacts. (United States)

    Yanson, I K; Fisun, V V; Naidyuk, Yu G; Balkashin, O P; Triputen, L Yu; Konovalenko, A; Korenivski, V


    Point contacts between normal and ferromagnetic metals are investigated using magnetoresistance and transport spectroscopy measurements combined with micromagnetic simulations. Pronounced hysteresis in the point contact resistance versus both bias current and external magnetic field are observed. It is found that such hysteretic resistance can exhibit, in addition to bi-stable resistance states found in ordinary spin valves, tri-stable resistance states with a middle resistance level. We interpret these observations in terms of surface spin valve and spin vortex states, originating from a substantially modified spin structure at the ferromagnetic interface in the contact core. We argue that these surface spin states, subject to a weakened exchange interaction, dominate the effects of spin transfer torques on the nanometer scale.

  1. Current driven tri-stable resistance states in magnetic point contacts

    Energy Technology Data Exchange (ETDEWEB)

    Yanson, I K; Fisun, V V; Naidyuk, Yu G; Balkashin, O P; Triputen, L Yu [B Verkin Institute for Low Temperature Physics and Engineering, National Academy of Sciences of Ukraine, 47 Lenin Avenue, 61103, Kharkiv (Ukraine); Konovalenko, A; Korenivski, V [Nanostructure Physics, Royal Institute of Technology, 10691, Stockholm (Sweden)


    Point contacts between normal and ferromagnetic metals are investigated using magnetoresistance and transport spectroscopy measurements combined with micromagnetic simulations. Pronounced hysteresis in the point contact resistance versus both bias current and external magnetic field are observed. It is found that such hysteretic resistance can exhibit, in addition to bi-stable resistance states found in ordinary spin valves, tri-stable resistance states with a middle resistance level. We interpret these observations in terms of surface spin valve and spin vortex states, originating from a substantially modified spin structure at the ferromagnetic interface in the contact core. We argue that these surface spin states, subject to a weakened exchange interaction, dominate the effects of spin transfer torques on the nanometer scale.

  2. Economic stagnation postponed: background of the 2008 financial-economic crisis in the European Union and the United States

    NARCIS (Netherlands)

    Reuten, G.


    The significant increase since the early 1980s in the share of income accruing to capital (rather than labor), in both the United States and the European Union, created the potential for economic stagnation. Stagnation was postponed, however, by the development of the banking sector in these countri

  3. An Explosives Products Thermodynamic Equation of State Appropriate for Material Acceleration and Overdriven Detonation: Theoretical Background and Formulation (United States)


    9 i 1 Normally, the equation of state parameters are chosen so that E. has the value E. = p0AH, where AH is the heat of detonation . This is consistent...Initial Specific Volume a Gruneisen Parameter 7 Adiabatic Gamnma C Sound Speed D) Detonation Velocity U mMass Velocity A 1l Heat of Detonation B ;., R xi

  4. Drug-related disorders and the criminal and clinical background of the prison population of Sao Paulo State, Brazil.

    Directory of Open Access Journals (Sweden)

    Maíra Mendes dos Santos

    Full Text Available OBJECTIVE: To analyze the association between drug (DAD and alcohol (AAD abuse and dependency and criminal and clinical background by gender of prisoners in São Paulo, Brazil. METHOD: Cross-sectional study, random sample stratified by administrative district, from which prisons and prisoners were selected via random, multistage sampling. Psychiatric diagnoses were made with the CIDI 2.1. Lifetime prevalence and 95% CI were calculated and adjusted via analysis of complex samples. Multinomial logistic regression analysis was carried out with four categories of dependent variables: presence AAD; presence DAD; presence of another mental disorder; no mental disorders. For female alcohol and drug abuse and dependency (ADAD were combined into a single category. RESULTS: The sample was composed by 1809 interviewed prisoners (1192 men and 617 women. Prevalence of DAD and AAD was 25.2% and 15.6%, respectively, among female prisoners, and 26.5% and 18.5% among males. Male prisoners with DAD were more likely to have a criminal record as an adolescent (OR 2.17, to be a repeat offender (OR 2.85, and to have committed a property crime (OR 2.18. Prisoners with AAD were repeat offenders (OR 2.18. Among female prisoners, ADAD was associated with repeat offenses (OR 3.39, a criminal record as an adolescent (OR 9.24, a clinical or infectious condition (OR 5.09, another health problem (OR 3.04, and violent crime (OR 2.5. CONCLUSION: The study confirmed an association between drug-use disorders and the criminal and clinical background in the study population. Prisoners with such disorders were more likely to be repeat offenders and to have a criminal record as adolescents. Among female prisoners disorders were also associated with violent crime and health problems, while among males they were associated with property crime. These patterns in clinical and criminal backgrounds illustrate the need for social rehabilitation programs and specific medical treatment for

  5. Practitioner Perspectives on the Current Status of Agriculture Education in the United States

    Institute of Scientific and Technical Information of China (English)

    Victor C X Wang


    For modern nations, a healthy agricultural sector provides the necessary foundation for the economic growth and social progress that enhance their citizens′ quality of life.Historically, agriculture education has been a dynamic and growing facet of career and technical education in the United States. Currently, however, public policy and support for agriculture education is negatively impacted by a national attitude that devalues agriculture education and perceives it as less desirable than a four-year college degree. This paper considers the history, scope, and current status of agriculture education in the context of increasing worldwide demand for agricultural products and rapidly changing technology.

  6. Current state of methodological and decisions for radiation treatment of blood, its components and products

    Directory of Open Access Journals (Sweden)

    Gordeev A.V.


    Full Text Available This article presents currently used blood transfusion media — components and blood products, therapeutic effects, reactions and complications of blood transfusion, use of radiation treatment for blood transfusion fluids. There had been discussed in detail the practice of radiation processing of blood components and for the prevention of reaction "graft versus host" and studies of plasma radiation treatment for its infectious safety. There was presented the current state of techniques and technical solutions of radiation treatment of transfusion-transmissible environments. There were also considered an alternative to radiation treatment of blood.

  7. Conservation assessment of current and proposed nature reserves of Tamaulipas state, Mexico (United States)

    Cantu, C.; Gerald, Wright R.; Michael, Scott J.; Strand, Espen


    The Mexican state of Tamaulipas located in the northeastern portion of the country currently has five state nature reserves covering slightly less than 3% of its land area. These reserves were established for a variety of reasons, many unrelated to the protection of biological resources. In 2000 in response to a growing concern about the lack of organized conservation reserve planning to protect the important biological and physical features of Mexico, the Mexican Commission for Knowledge and Use of Biodiversity (CONABIO) proposed 13 new terrestrial reserves for Tamaulipas. If established these new reserves would increase the proportion of terrestrial protected lands in the state to over 21%. We compiled a geographic information system (GIS) using existing digital thematic maps of physical and biological features to examine how the existing and proposed reserves might serve to protect the biodiversity and physical features of the state. We found that most of the existing protected sites occur in areas with elevations > 1000-2000 m with temperate climate and dominated by pine forest, oak forest, and cloud forest vegetation cover types. The state's dominant biotic region - low elevation coastal plain with tropical and arid climate types and xeric scrub vegetation - is disproportionately underrepresented in the current reserve system. The creation of the proposed areas would substantially increase the protection of mid and high elevation lands. The largest gap in the protected lands network would be low elevation, level, coastal lands.


    Directory of Open Access Journals (Sweden)

    І. Hrytsyniak


    Full Text Available Purpose. Fisheries has a strategic importance for supplying the population with food, while the sectors of the national economy with raw materials, for strengthening the country’s position in the international arena, for preserving spatial and national integrity of Ukraine, plays an important role in the restoration of natural resources and in the increase in employment. In recent years, fisheries sector of Ukraine is in a severe, protracted economic crisis. Considering its socio-economic and strategic importance for the state, there is a task for developing an effective policy for fisheries development in Ukraine that defines the relevance of the research and practical importance of its results. Thus, a compilation and analysis of the existing information on the current state and development of fisheries sector in the crisis period will allow a deeper understanding of problems in the fisheries sector in Ukraine and finding quick solutions. The main goal of the state policy in the field of fisheries in Ukraine has to be meeting the needs of the population in fish and fish products by creating conditions for effective operations and development of aquaculture and fishing enterprises. Findings. The article reviews the current state of the development of fisheries sector in Ukraine, consumption, catch, processing of fish and seafood, dynamics of fish product exports and imports, legislative and regulatory framework of fisheries sector, state of the implementation of WTO and EU requirements, as well as finding ways for the fisheries sector out from the crisis. Originality. This work is a compilation of the information on the current state of fisheries sector development in Ukraine. The information is provided in the form of a coherent presentation of information on the current state of fisheries sector in Ukraine, both in the domestic and foreign markets. Practical Value. The fact that the fisheries sector of Ukraine is still in a depressive state

  9. [Management in nursing in the current state impoverishment of working conditions]. (United States)

    Bellato, Roseney; Pereira, Wilza Rocha


    This study aims to provide reflection points on the nursing management process in the current state impoverishment financial conditions facing nursing work in a public health service in the State of Mato Grosso. We used the concepts of vulnerability, user rights and ethic to seek to understand how these concepts can broaden the view of citizenship in the search for better health care conditions for the users and workers in the institution studied. The blatant impoverishment of conditions that was detected point to the need for more awareness raising all levels where we think about, carry out and submit ourselves to the health care Nursing, working conditions, nursing ethics.


    Directory of Open Access Journals (Sweden)

    L. M. Vasileva


    Full Text Available The article considers the issues of current degraded state of aquatic biological resources of the Volga-Caspian Sea basin and provides specific data on commercial stocks of fish. The main reasons for decrease in natural stocks of ichthyofauna are regulation and pollution of the spawning rivers, adverse hydrological conditions, injudicious hunting, poaching pressure. To improve the state of natural stocks of fish it is necessary to increase their reproduction and implement measures to restore and rational exploitation of aquatic bioresources of the Volga- Caspian Sea basin.

  11. Sampled-current voltammetry at microdisk electrodes: kinetic information from pseudo steady state voltammograms. (United States)

    Perry, Samuel C; Al Shandoudi, Laila M; Denuault, Guy


    In sampled-current voltammetry (SCV), current transients acquired after stepping the potential along the redox wave of interest are sampled at a fixed time to produce a sigmoidal current-potential curve akin to a pseudo steady state voltammogram. Repeating the sampling for different times yields a family of sampled-current voltammograms, one for each time scale. The concept has been used to describe the current-time-potential relationship at planar electrodes but rarely employed as an electroanalytical method except in normal pulse voltammetry where the chronoamperograms are sampled once to produce a single voltammogram. Here we combine the unique properties of microdisk electrodes with SCV and report a simple protocol to analyze and compare the microdisk sampled-current voltammograms irrespective of sampling time. This is particularly useful for microelectrodes where cyclic voltammograms change shape as the mass transport regime evolves from planar diffusion at short times to hemispherical diffusion at long times. We also combine microdisk sampled-current voltammetry (MSCV) with a conditioning waveform to produce voltammograms where each data point is recorded with the same electrode history and demonstrate that the waveform is crucial to obtaining reliable sampled-current voltammograms below 100 ms. To facilitate qualitative analysis of the voltammograms, we convert the current-potential data recorded at different time scales into a unique sigmoidal curve, which clearly highlights kinetic complications. To quantitatively model the MSCVs, we derive an analytical expression which accounts for the diffusion regime and kinetic parameters. The procedure is validated with the reduction of Ru(NH3)6(3+), a model one electron outer sphere process, and applied to the derivation of the kinetic parameters for the reduction of Fe(3+) on Pt microdisks. The methodology reported here is easily implemented on computer controlled electrochemical workstations as a new

  12. Current tobacco use among middle and high school students--United States, 2011. (United States)


    Tobacco use continues to be the leading preventable cause of death and disease in the United States, with nearly 443,000 deaths occurring annually because of cigarette smoking and exposure to secondhand smoke. Moreover, nearly 90% of adult smokers begin smoking by age 18 years. To assess current tobacco use among youths, CDC analyzed data from the 2011 National Youth Tobacco Survey (NYTS). This report describes the results of that analysis, which indicated that, in 2011, the prevalence of current tobacco use among middle school and high school students was 7.1% and 23.2%, respectively, and the prevalence of current cigarette use was 4.3%, and 15.8%, respectively. During 2000-2011, among middle school students, a linear downward trend was observed in the prevalence of current tobacco use (14.9% to 7.1%), current combustible tobacco use (14.0% to 6.3%), and current cigarette use (10.7% to 4.3%). For high school students, a linear downward trend also was observed in these measures (current tobacco use [34.4% to 23.2%], current combustible tobacco use [33.1% to 21.0%], and current cigarette use [27.9% to 15.8%]). Interventions that are proven to prevent and reduce tobacco use among youths include media campaigns, limiting advertisements and other promotions, increasing the price of tobacco products, and reducing the availability of tobacco products for purchase by youths. These interventions should continue to be implemented as part of national comprehensive tobacco control programs and should be coordinated with Food and Drug Administration (FDA) regulations restricting the sale, distribution, and marketing of cigarettes and smokeless tobacco products to youths.

  13. English-Lithuanian-English Machine Translation lexicon and engine: current state and future work

    CERN Document Server

    Barisevičius, G


    This article overviews the current state of the English-Lithuanian-English machine translation system. The first part of the article describes the problems that system poses today and what actions will be taken to solve them in the future. The second part of the article tackles the main issue of the translation process. Article briefly overviews the word sense disambiguation for MT technique using Google.

  14. Localized excitations in nonlinear complex systems current state of the art and future perspectives

    CERN Document Server

    Cuevas-Maraver, Jesús; Frantzeskakis, Dimitri; Karachalios, Nikos; Kevrekidis, Panayotis; Palmero-Acebedo, Faustino


    The study of nonlinear localized excitations is a long-standing challenge for research in basic and applied science, as well as engineering, due to their importance in understanding and predicting phenomena arising in nonlinear and complex systems, but also due to their potential for the development and design of novel applications. This volume is a compilation of chapters representing the current state-of-the-art on the field of localized excitations and their role in the dynamics of complex physical systems.

  15. Globalization of Gerontology Education: Current Practices and Perceptions for Graduate Gerontology Education in the United States


    MWANGI, SAMUEL M.; Yamashita, Takashi; EWEN, HEIDI H.; Manning, Lydia K.; KUNKEL, SUZANNE R.


    The purpose of this study is to document current practices and understandings about globalization of gerontology education in the United States. Better understanding of aging requires international perspectives in global communities. However, little is known about how globalization of gerontology education is practiced in U.S. graduate-level degree programs. The authors conducted qualitative interviews with representatives of the Association for Gerontology in Higher Education, the major nati...

  16. Fractal-Based Methods and Inverse Problems for Differential Equations: Current State of the Art


    Kunze, Herb E.; Davide La Torre; Franklin Mendivil; Manuel Ruiz Galán; Rachad Zaki


    We illustrate, in this short survey, the current state of the art of fractal-based techniques and their application to the solution of inverse problems for ordinary and partial differential equations. We review several methods based on the Collage Theorem and its extensions. We also discuss two innovative applications: the first one is related to a vibrating string model while the second one considers a collage-based approach for solving inverse problems for partial differential equations on ...

  17. The Cosmic Microwave Background


    Silk, Joseph


    This set of lectures provides an overview of the basic theory and phenomenology of the cosmic microwave background. Topics include a brief historical review; the physics of temperature and polarization fluctuations; acoustic oscillations of the primordial plasma; the space of inflationary cosmological models; current and potential constraints on these models from the microwave background; and constraints on inflation.

  18. The Financial System of the New EU Member States: Experiences and Current Challenges

    Directory of Open Access Journals (Sweden)

    Angela ROMAN


    Full Text Available The current financial crisis has had a severe impact on the European financial systems, reinforcing the ongoing discussion about the scale, scope, performance, safety and soundness of the financial system and its institutions. In this context, the purpose of this research is to highlight, using an empirical approach and a quantitative analysis, the vulnerabilities accumulated by the financial systems from the new EU member states (Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania during the period before the current global economic crisis broke out and to emphasize the extremely serious consequences of the current crisis on their financial systems, the interaction between the financial sector and the real economy, the measures taken by the authorities in order to avoid the collapse of financial systems, as well as the new challenges aroused for the authorities in the current context. Finally, we argue then that building a safer financialsystem with better crisis management and a compelling solution forburden‐sharing should be the current priority.

  19. The current state and trends of the development of universities in Ukraine

    Directory of Open Access Journals (Sweden)

    O.B. Morhulets


    Full Text Available Education is the basis of social, political, economic, spiritual, and cultural development. Therefore, the study of the current state and trends of the development of Ukrainian universities is a significant factor of social and economic progress of the country.The paper reflects the general state of universities in Ukraine, in particular, the trends in dynamics: the number of students in terms of entry/graduation, sources of financing, education fields; the number of universities in the context of accreditation, types and forms of ownership; the number of outbound Ukrainian and inbound foreign students; quantitative and qualitative characteristics of teaching staff; spending on higher education and the cost of funding per student compared with other countries. The purpose of the study is the assessment of economic activity of higher educational establishments in Ukraine, the identification of problems and tendencies of their development in the context of national transformational processes in education and formation of the society of knowledge. The methodical base used in the study is analysis and synthesis, methods of comparison and generalization, extrapolation, index and graphical methods. The practical value of the study is based on the results of a thorough analysis of university activities. Such results reveal the current state and trends of the development of universities under conditions of higher education transformation in Ukraine and its integration into the European educational area. The results of research improve understanding of the state and problems of the universities and provide the foundations for further research in the field of the national education system development and for improving of the quality of young professionals’ training. The trends of the university development indicate that the reorganization of higher education which is being currently taken place, already results in the emergence of new competencies of

  20. Background Material

    DEFF Research Database (Denmark)

    Zandersen, Marianne; Hyytiäinen, Kari; Saraiva, Sofia;


    This document serves as a background material to the BONUS Pilot Scenario Workshop, which aims to develop harmonised regional storylines of socio-ecological futures in the Baltic Sea region in a collaborative effort together with other BONUS projects and stakeholders....

  1. Abrupt millennial variability and interdecadal-interstadial oscillations in a global coupled model: sensitivity to the background climate state

    Energy Technology Data Exchange (ETDEWEB)

    Arzel, Olivier [The University of New South Wales, Climate Change Research Centre (CCRC), Sydney (Australia); Universite de Bretagne Occidentale, Laboratoire de Physique des Oceans (LPO), Brest (France); England, Matthew H. [The University of New South Wales, Climate Change Research Centre (CCRC), Sydney (Australia); Verdiere, Alain Colin de; Huck, Thierry [Universite de Bretagne Occidentale, Laboratoire de Physique des Oceans (LPO), Brest (France)


    The origin and bifurcation structure of abrupt millennial-scale climate transitions under steady external solar forcing and in the absence of atmospheric synoptic variability is studied by means of a global coupled model of intermediate complexity. We show that the origin of Dansgaard-Oeschger type oscillations in the model is caused by the weaker northward oceanic heat transport in the Atlantic basin. This is in agreement with previous studies realized with much simpler models, based on highly idealized geometries and simplified physics. The existence of abrupt millennial-scale climate transitions during glacial times can therefore be interpreted as a consequence of the weakening of the negative temperature-advection feedback. This is confirmed through a series of numerical experiments designed to explore the sensitivity of the bifurcation structure of the Atlantic meridional overturning circulation to increased atmospheric CO{sub 2} levels under glacial boundary conditions. Contrasting with the cold, stadial, phases of millennial oscillations, we also show the emergence of strong interdecadal variability in the North Atlantic sector during warm interstadials. The instability driving these interdecadal-interstadial oscillations is shown to be identical to that found in ocean-only models forced by fixed surface buoyancy fluxes, that is, a large-scale baroclinic instability developing in the vicinity of the western boundary current in the North Atlantic. Comparisons with modern observations further suggest a physical mechanism similar to that driving the 30-40 years time scale associated with the Atlantic multidecadal oscillation. (orig.)

  2. Relationship between the prevalence of hemoglobin S and the ethnic background of blood donors in Paraná state

    Directory of Open Access Journals (Sweden)

    Kárita C. F. Lidani


    Full Text Available ABSTRACTIntroduction:Hemoglobin S (HbS is one of the most common inherited hematological disorders in humans. In Brazil, the sickle-cell disease (SCD has significant epidemiological importance due to its prevalence and the morbidity-mortality and, therefore, it has been identified as a matter of public health.Objective:To determine the prevalence of HbS among Asian Brazilian, Afro Brazilian, and Euro Brazilian individuals of a blood bank in Curitiba.Material and method:The study was conducted from January 2008 to December 2009, and included 83,213 donors seen at the Instituto Paranaense de Hemoterapia e Hematologia.Results and discussion:The prevalence of HbS in the studied population was 0.9%, among them, 0% Asian Brazilians, 2.7% Afro Brazilians, and 0.7% Euro Brazilians. There was a positive association, statistically significant for the sickle cell trait in Afro-descendants, with odds ratio (OR 4.01; confidence interval (CI 3.42-4.72; and 95% confidence.Conclusion:This study showed higher rates of sickle cell trait in Afro Brazilians, which corroborates data published in other Brazilian regions and states.

  3. Application of a rule-based model to estimate mercury exchange for three background biomes in the continental United States. (United States)

    Hartman, Jelena S; Weisberg, Peter J; Pillai, Rekha; Ericksen, Jody A; Kuiken, Todd; Lindberg, Steve E; Zhang, Hong; Rytuba, James J; Gustin, Mae S


    Ecosystems that have low mercury (Hg) concentrations (i.e., not enriched or impacted by geologic or anthropogenic processes) cover most of the terrestrial surface area of the earth yet their role as a net source or sink for atmospheric Hg is uncertain. Here we use empirical data to develop a rule-based model implemented within a geographic information system framework to estimate the spatial and temporal patterns of Hg flux for semiarid deserts, grasslands, and deciduous forests representing 45% of the continental United States. This exercise provides an indication of whether these ecosystems are a net source or sink for atmospheric Hg as well as a basis for recommendation of data to collect in future field sampling campaigns. Results indicated that soil alone was a small net source of atmospheric Hg and that emitted Hg could be accounted for based on Hg input by wet deposition. When foliar assimilation and wet deposition are added to the area estimate of soil Hg flux these biomes are a sink for atmospheric Hg.

  4. Description of plasma focus current sheath as the Turner relaxed state of a Hall magnetofluid (United States)

    Auluck, S. K. H.


    The central mystery of plasma focus research is the two orders-of-magnitude-higher-than-thermal fusion reaction rate and the fact that both the space-resolved neutron spectra and space-resolved reaction proton spectra show features which can be ascribed only to a rotational motion of the center-of-mass of the reacting deuteron population. It has been suggested earlier [S. K. H. Auluck, IEEE Trans. Plasma Sci. 25, 37 (1997)] that this and other experimental observations can be consistently explained in terms of a hypothesis involving rotation of the current carrying plasma annulus behind the imploding gas-dynamic shock. Such rotation (more generally, mass flow) is an in-built feature of relaxed state of a two-fluid plasma [R. N. Sudan, Phys. Rev. Lett. 42, 1277 (1979)]. Relaxation in the "Hall magnetofluid" approximation, in which the generalized Ohm's law includes the Hall effect term and the magnetic convection term but omits the contributions to the electric field from resistive dissipation, electron pressure gradient, thermoelectric effect, electron inertia, etc., has been extensively studied by many authors. In the present paper, Turner's [IEEE Trans. Plasma Sci. PS-14, 849 (1986)] degenerate solution for the relaxed state of the Hall magnetohydrodynamic plasma has been adapted to the case of an infinitely long annular current carrying plasma, a tractable idealization of the current sheath of a plasma focus. The resulting model is consistent with experimental values of ion kinetic energy and observation of predominantly radially directed neutron emission in good shots.

  5. Fed-state gastric media and drug analysis techniques: Current status and points to consider. (United States)

    Baxevanis, Fotios; Kuiper, Jesse; Fotaki, Nikoletta


    Gastric fed state conditions can have a significant effect on drug dissolution and absorption. In vitro dissolution tests with simple aqueous media cannot usually predict drugs' in vivo response, as several factors such as the meal content, the gastric emptying and possible interactions between food and drug formulations can affect drug's pharmacokinetics. Good understanding of the effect of the in vivo fed gastric conditions on the drug is essential for the development of biorelevant dissolution media simulating the gastric environment after the administration of the standard high fat meal proposed by the FDA and the EMA in bioavailability/bioequivalence (BA/BE) studies. The analysis of drugs in fed state media can be quite challenging as most analytical protocols currently employed are time consuming and labour intensive. In this review, an overview of the in vivo gastric conditions and the biorelevant media used for their in vitro simulation are described. Furthermore an analysis of the physicochemical properties of the drugs and the formulations related to food effect is given. In terms of drug analysis, the protocols currently used for the fed state media sample treatment and analysis and the analytical challenges and needs emerging for more efficient and time saving techniques for a broad spectrum of compounds are being discussed.

  6. Limitations of STIRAP-like population transfer in extended systems: the three-level system embedded in a web of background states. (United States)

    Jakubetz, Werner


    This paper presents a systematic numerical investigation of background state participation in STIRAP (stimulated Raman-adiabatic passage) population transfer among vibrational states, focusing on the consequences for the robustness of the method. The simulations, which are performed over extended grids in the parameter space of the Stokes- and pump pulses (frequencies, field strengths, and pulse lengths), involve hierarchies of (3 + N)-level systems of increasing complexity, ranging from the standard three-level STIRAP setup, (N = 0) in Λ-configuration, up to N = 446. A strongly coupled three-level core system is selected from the full Hamiltonian of the double-well HCN∕HNC system, and the couplings connecting this core system to the remaining states are (re-) parameterized in different ways, from very weak to very strong. The systems so obtained represent a three-level system embedded in various ways in webs of cross-linked vibrational background states and incorporate typical molecular properties. We first summarize essential properties of population transfer in the standard three-level system and quantify the robustness of the method and its dependence on the pulse parameters. Against these reference results, we present results obtained for four (3 + 446)-level systems and several subsystems. For pulse lengths of at most few picoseconds the intrinsic robustness of STIRAP with respect to variations in the field strength disappears as soon as the largest core-background couplings exceed about one tenth of the STIRAP couplings. In such cases robustness with respect to variations in the field strength is entirely lost, since at higher field strengths, except for irregularly spaced narrow frequency ranges, transfer probabilities are strongly reduced. STIRAP-like population transfer is maintained, with some restrictions, at low field strengths near the onset of adiabatic transfer. The suppression of STIRAP is traced back to different mechanisms based on a

  7. Assessment of Energy Production Potential from Ocean Currents along the United States Coastline

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Kevin


    Increasing energy consumption and depleting reserves of fossil fuels have resulted in growing interest in alternative renewable energy from the ocean. Ocean currents are an alternative source of clean energy due to their inherent reliability, persistence and sustainability. General ocean circulations exist in the form of large rotating ocean gyres, and feature extremely rapid current flow in the western boundaries due to the Coriolis Effect. The Gulf Stream system is formed by the western boundary current of the North Atlantic Ocean that flows along the east coastline of the United States, and therefore is of particular interest as a potential energy resource for the United States. This project created a national database of ocean current energy resources to help advance awareness and market penetration in ocean current energy resource assessment. The database, consisting of joint velocity magnitude and direction probability histograms, was created from data created by seven years of numerical model simulations. The accuracy of the database was evaluated by ORNL?s independent validation effort documented in a separate report. Estimates of the total theoretical power resource contained in the ocean currents were calculated utilizing two separate approaches. Firstly, the theoretical energy balance in the Gulf Stream system was examined using the two-dimensional ocean circulation equations based on the assumptions of the Stommel model for subtropical gyres with the quasi-geostrophic balance between pressure gradient, Coriolis force, wind stress and friction driving the circulation. Parameters including water depth, natural dissipation rate and wind stress are calibrated in the model so that the model can reproduce reasonable flow properties including volume flux and energy flux. To represent flow dissipation due to turbines additional turbine drag coefficient is formulated and included in the model. Secondly, to determine the reasonableness of the total power

  8. [Pathological gambling and computergame-addiction. Current state of research regarding two subtypes of behavioural addiction]. (United States)

    Wölfling, K; Müller, K W


    Behavioral addictions, like pathological gambling and computer game addiction (or internet addiction), have become a growing concern in research and public interest. Currently similarities between behavioral addictions and substance dependency are controversially discussed in the scientific community. Unfortunately a mismatch exists between the large number of people seeking treatment and the small number of scientific studies on pathological gambling and computer game addiction. Prevalence of pathological gambling among the German population is estimated to be 0.2-0.5%. These estimations are comparable to prevalence rates reported for drug dependency. Latest research states that about 3% of German adolescents and young adults are believed to suffer from computer game addiction. Therefore, it is important to enhance investigations regarding the clinical and neuroscientific basis of computer game addiction. This review offers a summary of current results of research regarding pathological gambling and internet addiction. The phenomenological description of these two disorders is meant to allow a deeper understanding of behavioral addictions.

  9. The History of Liquid Ear Acupuncture and the Current Scientific State of the Art. (United States)

    Litscher, Daniela; Litscher, Gerhard


    This short review article presents a current overview of existing publications and scientific results regarding liquid (ear) acupuncture. The injection of liquids into defined acupuncture points of the ear is not a method commonly used in the Western world. The term liquid acupuncture has different definitions, which makes understanding each definition and differentiating one from the other difficult. General terms like pharmacopuncture, homeosiniatry, and liquid acupuncture, which all describe the method of injecting different kinds of drugs into a defined body acupuncture point, are used. This article presents the history of liquid acupuncture, as well as the current scientific state of the art, from the point of view of two European researchers. Some articles are discussed and a few practical examples are presented.

  10. Mid to late Holocene Leeuwin Current variability offshore southern Australia linked to ENSO state changes (United States)

    Perner, Kerstin; Moros, Matthias; De Deckker, Patrick; Blanz, Thomas; Siegel, Herbert; Wacker, Lukas; Schneider, Ralph; Jansen, Eystein


    The El Niño-Southern Oscillation (ENSO), a key aspect of the Earth's climate, drives regional to global oceanic and climate changes on various time-scales. Differences in the temporal coverage of Holocene records for the more general state in El Niño frequency, however, restrict a comprehensive overview. Oceanic variability offshore southern Australia is linked to the Leeuwin Current (LC), an eastern boundary current, transporting tropical waters from the Indo Pacific Warm Pool region towards higher latitudes. Instrumental data, spanning the last few decades, document that ENSO modulates LC variability. Here we present new, well-dated time series from two marine sediment cores (MD03-2611 and SS0206-GC 15)of past LC variability, based on alkenone-derived sea-surface temperatures (SST) and planktonic foraminifera offshore southern Australia, an area affected by recent El Niño and La Niña events. Our reconstructions of ENSO-state changes cover the last 7,400 years. With transition into the mid Holocene [dates], we find clear evidence that oceanic conditions prevailed under the dominant influence of a persistent La Niña mode. A strong LC produces a stratified water column and establishes a permanent thermocline as seen in the high abundance of the 'tropical fauna' (Globoturborotalita rubescens, Globoturborotalita tenella and Globigerinella sacculifer (including G. trilobus)) and maximum SST offshore southern Australia. During this La Niña-state dominated period, we record at c. 5000 years BP the first short period of a strong El Niño-like-state, by a pronounced drop in abundance of the subtropical species Globigerinoides ruber and a reduced SST gradient between the two core sites. The Late Holocene (from 3,500 years BP onwards) period is characterized by centennial to millennial scale variability in the LC strength, which is accompanied by an overall decrease of SSTs offshore southern Australia. We link this LC variability to Late Holocene centennial

  11. Rapid Detection Strategies for the Global Threat of Zika Virus: Current State, New Hypotheses and Limitations

    Directory of Open Access Journals (Sweden)

    Shruti Shukla


    Full Text Available The current scenario regarding the widespread Zika virus (ZIKV has resulted in numerous diagnostic studies, specifically in South America and in locations where there is frequent entry of travelers returning from ZIKV-affected areas, including pregnant women with or without clinical symptoms of ZIKV infection. The World Health Organization, WHO, announced that millions of cases of ZIKV are likely to occur in the United States of America in the near future. This situation has created an alarming public health emergency of international concern requiring the detection of this life-threatening viral candidate due to increased cases of newborn microcephaly associated with ZIKV infection. Hence, this review reports possible methods and strategies for the fast and reliable detection of ZIKV with particular emphasis on current updates, knowledge and new hypotheses that might be helpful for medical professionals in poor and developing countries that urgently need to address this problem. In particular, we emphasize liposome-based biosensors. Although these biosensors are currently among the less popular tools for human disease detection, they have become useful tools for the screening and detection of pathogenic bacteria, fungi and viruses because of their versatile advantageous features compared to other sensing devices. This review summarizes the currently available methods employed for the rapid detection of ZIKV and suggests an innovative approach involving the application of a liposome-based hypothesis for the development of new strategies for ZIKV detection and their use as effective biomedicinal tools.

  12. Random phase approximation with second-order screened exchange for current-carrying atomic states (United States)

    Zhu, Wuming; Zhang, Liang; Trickey, S. B.


    The direct random phase approximation (RPA) and RPA with second-order screened exchange (SOSEX) have been implemented with complex orbitals as a basis for treating open-shell atoms. Both RPA and RPA+SOSEX are natural implicit current density functionals because the paramagnetic current density implicitly is included through the use of complex orbitals. We confirm that inclusion of the SOSEX correction improves the total energy accuracy substantially compared to RPA, especially for smaller-Z atoms. Computational complexity makes post self-consistent-field (post-SCF) evaluation of RPA-type expressions commonplace, so orbital basis origins and properties become important. Sizable differences are found in correlation energies, total atomic energies, and ionization energies for RPA-type functionals evaluated in the post-SCF fashion with orbital sets obtained from different schemes. Reference orbitals from Kohn-Sham calculations with semi-local functionals are more suitable for RPA+SOSEX to generate accurate total energies, but reference orbitals from exact exchange (non-local) yield essentially energetically degenerate open-shell atom ground states. RPA+SOSEX correlation combined with exact exchange calculated from a hybrid reference orbital set (half the exchange calculated from exact-exchange orbitals, the other half of the exchange from orbitals optimized for the Perdew-Burke-Ernzerhof (PBE) exchange functional) gives the best overall performance. Numerical results show that the RPA-like functional with SOSEX correction can be used as a practical implicit current density functional when current effects should be included.

  13. State-of-Art Empirical Modeling of Ring Current Plasma Pressure (United States)

    Yue, C.; Ma, Q.; Wang, C. P.; Bortnik, J.; Thorne, R. M.


    The plasma pressure in the inner magnetosphere plays a key role in plasma dynamics by changing magnetic field configurations and generating the ring current. In this study, we present our preliminary results of empirically constructing 2D equatorial ring current pressure and pressure anisotropy spatial distributions controlled by Dst based on measurements from two particle instruments (HOPE and RBSPICE) onboard Van Allen Probes. We first obtain the equatorial plasma perpendicular and parallel pressures for different species including H+, He+, O+ and e- from 20 eV to ~1 MeV, and investigate their relative contributions to the total plasma pressure and pressure anisotropy. We then establish empirical equatorial pressure models within ~ 6 RE using a state-of-art machine learning technique, Support Vector Regression Machine (SVRM). The pressure models predict equatorial perpendicular and parallel plasma thermal pressures (for each species and for total pressures) and pressure anisotropy at any given r, MLT, Bz/Br (equivalent Z distance), and Dst within applicable ranges. We are currently validating our model predictions and investigating how the ring current pressure distributions and the associated pressure gradients vary with Dst index.

  14. Russian language as a state language: current status and measures for its strengthening and development

    Directory of Open Access Journals (Sweden)

    Verbitskaya L. A.


    Full Text Available The focus of the article is the role of the Russian language in the world system of languages, the current status of the Russian language and the language policy measures that should be taken to preserve the Russian language and for the strengthening of its positions. The law “On the state language of the Russian Federation” adopted in 2005 should be supplemented by the list of grammar books and dictionaries of various types as listed in the appendixes to the article. The main actions aimed at ensuring the effective functioning of the law “On the state language of the Russian Federation” are also enlisted in the article.

  15. The current state of the art of quantitative phosphoproteomics and its applications to diabetes research

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Chi Yuet X’avia; Gritsenko, Marina A.; Smith, Richard D.; Qian, Wei-Jun


    Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been revealed in various human diseases. Kinases and their cognate inhibitors have been hotspot for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for the disease of interest. In this review, we will highlight recent advances in phosphoproteomics, the current state-of-the-art of the technologies, and the challenges and future perspectives of this research area. Finally, we will underscore some exemplary applications of phosphoproteomics in diabetes research.

  16. Measuring neutrino-induced exclusive charge-current final states on hydrogen at T2K

    CERN Document Server

    Coplowe, David; Barr, Giles


    By taking advantage of symmetries with respect to the plane containing the directions of the neutrino and outgoing lepton, it is possible to isolate neutrino interactions on hydrogen in composite nuclear targets. This technique enables us to study the `primary' neutrino-nucleon interaction and therefore gain access to fundamental model parameters free from nuclear effects. Using T2K Monte Carlo equivalent to $\\sim7\\times10^{21}$ POT, we present an update on the measurement of the exclusive charged-current $\\mu^-$, p, $\\pi^+$ final state on hydrogen.

  17. Learning Styles of Pilots Currently Qualified in United States Air Force Aircraft (United States)

    Kanske, Craig A.


    Kolb's Learning Style Inventory was used to identify the predominant learning styles of pilots currently qualified in United States Air Force aircraft. The results indicate that these pilots show a significant preference for facts and things over people and feelings. By understanding the preferred learning styles of the target population, course material can be developed that take advantage of the strengths of these learning styles. This information can be especially useful in the future design of cockpit resource management training. The training program can be developed to demonstrate both that there are different learning styles and that it is possible to take advantage of the relative strengths of each of these learning styles.

  18. Joystick control for powered mobility: current state of technology and future directions. (United States)

    Dicianno, Brad E; Cooper, Rory A; Coltellaro, John


    Recent advancements in control interface technology have made the use of end devices such as power wheelchairs easier for individuals with disabilities, especially persons with movement disorders. In this article, we discuss the current state of control interface technology and the devices available clinically for power wheelchair control. We also discuss our research on novel hardware and software approaches that are revolutionizing joystick interface technology and allowing more customizability for individual users with special needs and abilities. Finally, we discuss the future of control interfaces and what research gaps remain.

  19. Current state and problems of noble hardwoods plants: the Regions’ point of view

    Directory of Open Access Journals (Sweden)

    Calvo E


    Full Text Available This paper illustrates the current state of noble hardwoods plants established in Italy since early ’90s, with the aim of describing the extension, distribution and quality of wood production obtained. Based on both results of this investigation and advices issued by administrative Regions, several considerations are discussed aimed to identify new directions for research and extension activities, as well as to support appropriate managing practices, in the light of the absence of an integrated system among the noble hardwoods productions, the agricultural sector and the timber market.

  20. Assessment of Current State of Mooring Design in the Danish Wave Energy Sector

    DEFF Research Database (Denmark)

    Thomsen, Jonas Bjerg; Ferri, Francesco; Kofoed, Jens Peter


    The mooring system is a vital part of any floating wave energy converter, both in terms of ensuring station keeping but also as it constitutes a significant share of the total cost. Motivatedby the considerable amount of failures due to insufficient mooring and the cost of mooring today......, the present study outlines the design procedure recommended by design standards and provides considerations on choice of tools for analysis. This is compared to the procedure used by four wave energy converter developers, to illustrate the state of their current mooring design. The study shows a clear...

  1. The current state of the art of quantitative phosphoproteomics and its applications to diabetes research. (United States)

    Chan, Chi Yuet X'avia; Gritsenko, Marina A; Smith, Richard D; Qian, Wei-Jun


    Protein phosphorylation is a fundamental regulatory mechanism in many cellular processes and aberrant perturbation of phosphorylation has been implicated in various human diseases. Kinases and their cognate inhibitors have been considered as hotspots for drug development. Therefore, the emerging tools, which enable a system-wide quantitative profiling of phosphoproteome, would offer a powerful impetus in unveiling novel signaling pathways, drug targets and/or biomarkers for diseases of interest. This review highlights recent advances in phosphoproteomics, the current state of the art of the technologies and the challenges and future perspectives of this research area. Finally, some exemplary applications of phosphoproteomics in diabetes research are underscored.

  2. Current State of Agile Methodologies Worldwide and in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Martin Tománek


    Full Text Available The objective of this research paper is to compare the current state of agile methodologies in the world and in the Czech Republic. The comparison is executed as the comparative analysis of two publicly available researches conducted in 2013 and published in 2014. The comparison is further enriched by the results of the unpublished survey in the global logistics company which was conducted also in 2013. The potential trend for agile methodologies in the Czech Republic is also discussed with regard to the worldwide trend.

  3. State-dependent modulation of gap junction signaling by the persistent sodium current. (United States)

    Haas, Julie S; Landisman, Carole E


    THALAMIC NEURONS FLUCTUATE BETWEEN TWO STATES: a hyperpolarized state associated with burst firing and sleep spindles, and a depolarized state associated with tonic firing and rapid, reliable information transmission between the sensory periphery and cortex. The thalamic reticular nucleus (TRN) plays a central role in thalamocortical processing by providing feed-forward and feedback inhibition to thalamic relay cells; TRN cells participate in the generation of sleep spindles, and have been suggested to focus the neural "searchlight" of attention. The mechanisms underlying synchrony in the TRN during different behavioral states are largely unknown. TRN cells are densely interconnected by electrical synapses. Here we show that activation of the persistent sodium current (I(NaP)) by depolarization causes up to fourfold changes in electrical synaptic efficacy between TRN neurons. We further show that amplification of electrical synaptic responses strongly enhances tonic spike synchrony but, surprisingly, does not affect burst coordination. We use a Hodgkin-Huxley model to gain insight into the differences between the effects of burstlets, spikelets, and amplification on burst and spike times.

  4. State-dependent modulation of gap junction signaling by the persistent sodium current

    Directory of Open Access Journals (Sweden)

    Julie S Haas


    Full Text Available Thalamic neurons fluctuate between two states: a hyperpolarized state associated with burst firing and sleep spindles, and a depolarized state associated with tonic firing and rapid, reliable information transmission between the sensory periphery and cortex. The thalamic reticular nucleus (TRN plays a central role in thalamocortical processing by providing feed-forward and feedback inhibition to thalamic relay cells; TRN cells participate in the generation of sleep spindles, and have been suggested to focus the neural searchlight of attention. The mechanisms underlying synchrony in the TRN during different behavioral states are largely unknown. TRN cells are densely interconnected by electrical synapses. Here we show that activation of the persistent sodium current (INaP by depolarization causes up to four-fold changes in electrical synaptic efficacy between TRN neurons. We further show that amplification of electrical synaptic responses strongly enhances tonic spike synchrony but, surprisingly, does not affect burst coordination. We use a Hodgkin-Huxley model to gain insight into the differences between the effects of burstlets, spikelets and amplification on burst and spike times.

  5. An induction machine model including interbar currents for studying performances during transients and steady state

    Energy Technology Data Exchange (ETDEWEB)

    Razik, H. [Universite Henri Poincare, GREEN, CNRS-UMR 7037, BP 239, F-54506 Vandoeuvre-les-Nancy Cedex (France); Henao, H. [University of Picardie, CREA, 33 rue Saint Leu, F-80039 Amiens Cedex 1 (France); Carlson, R. [GRUCAD/CTC/UFSC, Campus Universitario, C.P. 436, Florianopolis - SC, 88040-900 (Brazil)


    This paper presents a mathematical model of a three-phase induction motor taking into consideration the interbar contacts. Several models have been available in the references. However, they consider the rotor of the induction motor as being constituted either a three-phase or a squirrel cage even if it operates under stator and/or rotor faults condition. Nonetheless, the contact between a bar and the iron core for the machine has to be considered, especially when a rotor fault occurs. It is obvious that rotor currents are under the influence of rotor constitution materials. So, the paper aim's concerns a transient model of the induction motors which can consider the rotor broken bars defect. Despite its increasing complexity, it could be able to provide with useful indications for diagnostic purposes. This model is advocated for the simulation of motors behavior under rotor defect which takes into account the interbar currents. The proposed technique is based on the mesh model analysis of the squirrel cage. As low power induction motors are prevalent in industrial plants, we pay a special attention on them. Notwithstanding, additional currents are due to the contact between the non-insulated bar constituting the squirrel cage to the rotor iron core. The monitoring of induction motors is predominantly made through the stator current analysis of the motor when it operates at nominal condition. Moreover, this one is observed in steady state operating system, knowing that the motor is generally fed by a sinusoidal supply. Consequently, simulation results showed in this paper prove the effectiveness of the proposed approach, and the impact of interbar resistance both on the model and the line current spectrum for the diagnostic. An experimental test proves the effectiveness of this model. (author)

  6. Interconnections between magnetic state and transport currents in antiferromagnetic Sr2IrO4 (United States)

    Tsoi, Maxim

    Interconnections between magnetic state and transport currents in ferromagnetic (F) heterostructures are the basis for spintronic applications, e.g. tunneling magnetoresistance and spin-transfer torque phenomena provide a means to read and write information in magnetic memory devices like STTRAM. Similar interconnections were proposed to occur in systems where F-components are replaced with antiferromagnets (AFM). We demonstrated experimentally the existence of such interconnections in antiferromagnetic Mott insulator Sr2IrO4: first, we found a very large anisotropic magnetoresistance (AMR) which can be used to monitor (read) the magnetic state of AFM; second, we demonstrated the feasibility of reversible resistive switching driven by high-density currents/high electric fields which can be used for writing in AFM memory applications. These results support the feasibility of AFM spintronics where antiferromagnets are used in place of ferromagnets. This work was supported in part by C-SPIN, one of six centers of STARnet, a Semiconductor Research Corporation program, sponsored by MARCO and DARPA, and by NSF grants DMR-1207577, DMR-1265162 and DMR-1122603.

  7. Current State of Technology of Fuel Cell Power Systems for Autonomous Underwater Vehicles

    Directory of Open Access Journals (Sweden)

    Alejandro Mendez


    Full Text Available Autonomous Underwater Vehicles (AUVs are vehicles that are primarily used to accomplish oceanographic research data collection and auxiliary offshore tasks. At the present time, they are usually powered by lithium-ion secondary batteries, which have insufficient specific energies. In order for this technology to achieve a mature state, increased endurance is required. Fuel cell power systems have been identified as an effective means to achieve this endurance but no implementation in a commercial device has yet been realized. This paper summarizes the current state of development of the technology in this field of research. First, the most adequate type of fuel cell for this application is discussed. The prototypes and design concepts of AUVs powered by fuel cells which have been developed in the last few years are described. Possible commercial and experimental fuel cell stack options are analyzed, examining solutions adopted in the analogous aerial vehicle applications, as well as the underwater ones, to see if integration in an AUV is feasible. Current solutions in oxygen and hydrogen storage systems are overviewed and energy density is objectively compared between battery power systems and fuel cell power systems for AUVs. A couple of system configuration solutions are described including the necessary lithium-ion battery hybrid system. Finally, some closing remarks on the future of this technology are given.

  8. Mass Casualty Decontamination in the United States: An Online Survey of Current Practice. (United States)

    Power, Sarah; Symons, Charles; Carter, Holly; Jones, Emma; Amlôt, Richard; Larner, Joanne; Matar, Hazem; Chilcott, Robert P


    Mass casualty decontamination is a public health intervention that would be employed by emergency responders following a chemical, biological, or radiological incident. The decontamination of large numbers of casualties is currently most often performed with water to remove contaminants from the skin surface. An online survey was conducted to explore US fire departments' decontamination practices and their preparedness for responding to incidents involving mass casualty decontamination. Survey respondents were asked to provide details of various aspects of their decontamination procedures, including expected response times to reach casualties, disrobing procedures, approaches to decontamination, characteristics of the decontamination showering process, provision for special populations, and any actions taken following decontamination. The aim of the survey was to identify any differences in the way in which decontamination guidance is implemented across US states. Results revealed that, in line with current guidance, many US fire departments routinely use the "ladder-pipe system" for conducting rapid, gross decontamination of casualties. The survey revealed significant variability in ladder-pipe construction, such as the position and number of fire hoses used. There was also variability in decontamination characteristics, such as water temperature and water pressure, detergent use, and shower duration. The results presented here provide important insights into the ways in which implementation of decontamination guidance can vary between US states. These inconsistencies are thought to reflect established perceived best practices and local adaptation of response plans to address practical and logistical constraints. These outcomes highlight the need for evidence-based national guidelines for conducting mass casualty decontamination.

  9. Transient analysis and control of bias magnetic state in the transformer of on-line pulse-width-modulation switching full bridge direct current-direct current converter (United States)

    Chen, Jiaxin; Guo, Youguang; Zhu, Jianguo; Wei Lin, Zhi


    This paper presents a finite element analysis (FEA) based method for analyzing and controlling the bias magnetic state of the transformer of a pulse-width-modulation (PWM) switching full bridge dc-dc converter. A field-circuit indirect coupling method for predicting the transient bias magnetic state is introduced first. To increase flexibility of the proposed method, a novel transformer model which can address not only its basic input-output characteristic, but also the nonlinear magnetizing inductance, is proposed. Both the asymmetric characteristic and the variable laws of the current flowing through the two secondary windings during the period of PWM switching-off state are highlighted. Finally, the peak magnetizing current controlled method based on the on-line magnetizing current computation is introduced. Analysis results show that this method can address the magnetic saturation at winding ends, and hence many previous difficulties, such as the start-up process and asymmetry of power electronics, can be easily controlled.

  10. Zimbabwe: Background (United States)


    12 Reporters Without Borders , “No Letup in Abusive Media Tactics Three Weeks Before Legislative Elections... Without Borders , a Paris-based organization that 8 “Title Deeds to 4,000 Farms Nullified...supporters suggested that voters simply lost faith in MDC promises. Opposition access to the state-run media was severely limited, according to Reporters

  11. Veterinarian-Client Communication Skills: Current State, Relevance, and Opportunities for Improvement. (United States)

    McDermott, Michael P; Tischler, Victoria A; Cobb, Malcolm A; Robbé, Iain J; Dean, Rachel S


    Communication is increasingly recognized as a core skill for veterinary practitioners, and in recent years, attention to communication competency and skills training has increased. To gain an up-to-date assessment of the current state of veterinary communication skills and training, we conducted a survey among veterinary practitioners in the United Kingdom and United States in 2012/2013. The questionnaire was used to assess the current state, relevance, and adequacy of veterinary communication skills among veterinary practitioners, to assess interest in further training, and to understand perceived challenges in communicating with clients. There was an overall response rate of 29.6% (1,774 of 6,000 recipients), with a higher response rate for UK-based practitioners (39.7%) than practitioners in the US (19.5%). Ninety-eight percent of respondents agreed that communication skills were as important as or more important than clinical knowledge. Forty-one percent of respondents had received formal veterinary communication skills training during veterinary school, and 47% had received training post-graduation. Thirty-five percent said their veterinary communication skills training during veterinary school prepared them well or very well for communicating with clients about the health of their pets, compared to 61% of those receiving post-graduate training. Forty percent said they would be interested in further veterinary communication skills training, with the preferred methods being simulated consultations and online training. While there has been increased emphasis on communication skills training during and after veterinary school, there is a need for more relevant and accessible training.

  12. Change in mean frequency of resting-state electroencephalography after transcranial direct current stimulation

    Directory of Open Access Journals (Sweden)

    Tjeerd W. Boonstra


    Full Text Available Transcranial direct current stimulation (tDCS is proposed as a tool to investigate cognitive functioning in healthy people and as a treatment for various neuropathological disorders. However, the underlying cortical mechanisms remain poorly understood. We aim to investigate whether resting-state electroencephalography (EEG can be used to monitor the effects of tDCS on cortical activity. To end we tested whether the spectral content of ongoing EEG activity is significantly different after a single session of active tDCS compared to sham stimulation. Twenty participants were tested in a sham-controlled, randomized, crossover design. Resting-state EEG was acquired before, during and after active tDCS to the left dorsolateral prefrontal cortex (15 min of 2mA tDCS and sham stimulation. Electrodes with a diameter of 3.14 cm2 were used for EEG and tDCS. Partial least squares (PLS analysis was used to examine differences in power spectral density and the EEG mean frequency to quantify the slowing of EEG activity after stimulation. PLS revealed a significant increase in spectral power at frequencies below 15 Hz and a decrease at frequencies above 15 Hz after active tDCS (P=0.001. The EEG mean frequency was significantly reduced after both active tDCS (P<0.0005 and sham tDCS (p=0.001, though the decrease in mean frequency was smaller after sham tDCS than after active tDCS (P=0.073. Anodal tDCS of the left DLPFC using a high current density bi-frontal electrode montage resulted in general slowing of resting-state EEG. The similar findings observed following sham stimulation question whether the standard sham protocol is an appropriate control condition for tDCS.


    Directory of Open Access Journals (Sweden)

    Khromova I. N.


    Full Text Available Current horticulture is a complex system of fruit crops cultivation based on the integrated using of material, labor, natural and financial resources. Horticulture is an important part of agriculture because of the high nutritional value of its products. The fruits are used fresh and as raw material for canning, wine and other industries. Modern methods of processing and freezing of products are making possible to save its nutritional value and extend the period of consumption. The main problem of the horticultural industry is providing the population with fresh, high quality fruits and products of their processing. Horticulture is in a state of dynamic changes associated with the economic situation in the region. The authors assessed the current status of horticulture in the Republic of Tajikistan, revealed the problems in the functioning of the industry in the current economic conditions. As a result of scientific investigation the authors have proved the impact of the financial-credit, tax, price factors, level of competition, investment policy. The authors identified promising directions of improving the efficiency of horticulture and found the advantages of intensive technology of fruit crops cultivation. The implementation of these arrangements will help to ensure the country's food security and agricultural development

  14. The current state of electronic consultation and electronic referral systems in Canada: an environmental scan. (United States)

    Liddy, Clare; Hogel, Matthew; Blazkho, Valerie; Keely, Erin


    Access to specialist care is a point of concern for patients, primary care providers, and specialists in Canada. Innovative e-health platforms such as electronic consultation (eConsultation) and referral (eReferral) can improve access to specialist care. These systems allow physicians to communicate asynchronously and could reduce the number of unnecessary referrals that clog wait lists, provide a record of the patient's journey through the referral system, and lead to more efficient visits. Little is known about the current state of eConsultation and eReferral in Canada. The purpose of this work was to identify current systems and gain insight into the design and implementation process of existing systems. An environmental scan approach was used, consisting of a systematic and grey literature review, and targeted semi-structured key informant interviews. Only three eConsultation/eReferral systems are currently in operation in Canada. Four themes emerged from the interviews: eReferral is an end goal for those provinces without an active eReferral system, re-organization of the referral process is a necessity prior to automation, engaging the end-user is essential, and technological incompatibilities are major impediments to progress. Despite the acknowledged need to improve the referral system and increase government spending on health information technology, eConsultation and eReferral systems remain scarce as Canada lags behind the rest of the developed world.

  15. Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions. (United States)

    Aggarwal, Sunil K; Carter, Gregory T; Sullivan, Mark D; ZumBrunnen, Craig; Morrill, Richard; Mayer, Jonathan D


    Cannabis (marijuana) has been used for medicinal purposes for millennia, said to be first noted by the Chinese in c. 2737 BCE. Medicinal cannabis arrived in the United States much later, burdened with a remarkably checkered, yet colorful, history. Despite early robust use, after the advent of opioids and aspirin, medicinal cannabis use faded. Cannabis was criminalized in the United States in 1937, against the advice of the American Medical Association submitted on record to Congress. The past few decades have seen renewed interest in medicinal cannabis, with the National Institutes of Health, the Institute of Medicine, and the American College of Physicians, all issuing statements of support for further research and development. The recently discovered endocannabinoid system has greatly increased our understanding of the actions of exogenous cannabis. Endocannabinoids appear to control pain, muscle tone, mood state, appetite, and inflammation, among other effects. Cannabis contains more than 100 different cannabinoids and has the capacity for analgesia through neuromodulation in ascending and descending pain pathways, neuroprotection, and anti-inflammatory mechanisms. This article reviews the current and emerging research on the physiological mechanisms of cannabinoids and their applications in managing chronic pain, muscle spasticity, cachexia, and other debilitating problems.

  16. Data-driven background estimates in searches for supersymmetry in final states with two same-sign leptons, jets and E{sub T}{sup miss} with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Tornambe, Peter; Cardillo, Fabio [Albert-Ludwigs Universitaet Freiburg (Germany)


    Supersymmetry is one of the most studied theories to extend the Standard Model. If R-parity is conserved, SUSY particles are produced in pairs and the lightest supersymmetric particle which is typically the lightest neutralino χ{sub 0}{sup 1} is stable. In many models the LSP can be a suitable candidate for dark matter. This talk presents a search for supersymmetric phenomena in final states with two leptons of the same electric charge, jets and missing transverse energy E{sub T}{sup miss}. While the same-sign leptons signature is present in many supersymmetric scenarios, SM processes leading to such events have very small cross-sections. Therefore, this analysis benefits from a small SM background in the signal regions leading to a good sensitivity especially in compressed regions of the SUSY phase-space. The other main sources for SM processes contaminating the signal regions are fake-leptons and leptons with a charge mis-identification. While background originating from prompt same-sign lepton sources is estimated with simulated Monte Carlo events, the non-prompt sources are addressed with data-driven techniques. Within this talk, the current analysis strategy in Run-II are presented focussing on the methods used for the background estimation and sensitivity optimization. But also the latest results obtained during the 2015 data-taking are shown.

  17. Advanced robotics for medical rehabilitation current state of the art and recent advances

    CERN Document Server

    Xie, Shane


    Focussing on the key technologies in developing robots for a wide range of medical rehabilitation activities – which will include robotics basics, modelling and control, biomechanics modelling, rehabilitation strategies, robot assistance, clinical setup/implementation as well as neural and muscular interfaces for rehabilitation robot control – this book is split into two parts; a review of the current state of the art, and recent advances in robotics for medical rehabilitation. Both parts will include five sections for the five key areas in rehabilitation robotics: (i) the upper limb; (ii) lower limb for gait rehabilitation (iii) hand, finger and wrist; (iv) ankle for strains and sprains; and (v) the use of EEG and EMG to create interfaces between the neurological and muscular functions of the patients and the rehabilitation robots. Each chapter provides a description of the design of the device, the control system used, and the implementation and testing to show how it fulfils the needs of that specific ...

  18. Current contraceptive status among women aged 15-44: United States, 2011-2013. (United States)

    Daniels, Kimberly; Daugherty, Jill; Jones, Jo


    Nearly all women use contraception at some point in their lifetimes, although at any given time they may not be using contraception for reasons such as seeking pregnancy, being pregnant, or not being sexually active. Using data from the 2011-2013 National Survey of Family Growth (NSFG) on contraceptive use in the month of the interview, this report provides a snapshot of current contraceptive status among women aged 15-44 in the United States. In addition to describing use of any method by age, Hispanic origin and race, and educational attainment, patterns of use are described for the four most commonly used contraceptive methods: the oral contraceptive pill, female sterilization, the male condom, and long-acting reversible contraceptives, which include contraceptive implants and intrauterine devices.

  19. Metacognition fundaments, applications, and trends a profile of the current state-of-the-art

    CERN Document Server


    This book is devoted to the Metacognition arena. It highlights works that show relevant analysis, reviews, theoretical, and methodological proposals, as well as studies, approaches, applications, and tools that shape current state, define trends and inspire future research. As a result of the revision process fourteen manuscripts were accepted and organized into five parts as follows: ·     Conceptual: contains conceptual works oriented to: (1) review models of strategy instruction and tailor a hybrid strategy; (2) unveil second-order judgments and define a method to assess metacognitive judgments; (3) introduces a conceptual model to describe the metacognitive activity as an autopoietic system. ·     Framework: offers three works concerned with: (4) stimulate metacognitive skills and self-regulatory functions; (5) evaluate metacognitive skills and self-regulated learning at problem solving; (6) deal with executive management metacognition and strategic knowledge metacognition. ·     Studies: r...

  20. African swine fever virus: current state and future perspectives in vaccine and antiviral research. (United States)

    Zakaryan, Hovakim; Revilla, Yolanda


    African swine fever (ASF) is among the most significant of swine diseases for which no effective vaccines and antivirals are available. The disease, which is endemic in Africa, was introduced to Trans-Caucasian countries and the Russian Federation in 2007, where it remains prevalent today among domestic pigs and wild boars. Although some measures were implemented, ASF continues to pose a global risk for all countries, and thereby highlighting the importance of vaccine and antiviral research. In this review, an overview of research efforts toward the development of effective vaccines during the past decades is presented. As an alternative to vaccine development, the current state in antiviral research against ASFV is also presented. Finally, future perspectives in vaccine and antiviral research giving emphasis on some strategies that may allow researchers to develop effective countermeasures against ASF are discussed.

  1. Aerospace Concurrent Engineering Design Teams: Current State, Next Steps and a Vision for the Future (United States)

    Hihn, Jairus; Chattopadhyay, Debarati; Karpati, Gabriel; McGuire, Melissa; Borden, Chester; Panek, John; Warfield, Keith


    Over the past sixteen years, government aerospace agencies and aerospace industry have developed and evolved operational concurrent design teams to create novel spaceflight mission concepts and designs. These capabilities and teams, however, have evolved largely independently. In today's environment of increasingly complex missions with limited budgets it is becoming readily apparent that both implementing organizations and today's concurrent engineering teams will need to interact more often than they have in the past. This will require significant changes in the current state of practice. This paper documents the findings from a concurrent engineering workshop held in August 2010 to identify the key near term improvement areas for concurrent engineering capabilities and challenges to the long-term advancement of concurrent engineering practice. The paper concludes with a discussion of a proposed vision for the evolution of these teams over the next decade.

  2. The current state of intestine transplantation: indications, techniques, outcomes and challenges. (United States)

    Sudan, D


    Intestine transplantation is the least common form of organ transplantation in the United States and often deemed one of the most difficult. Patient and graft survival have historically trailed well behind other organ transplants. Over the past 5-10 years registry reports and single center series have demonstrated improvements to patient survival after intestinal transplantation that now match patient survival for those without life-threatening complications on parenteral nutrition. For various reasons including improvements in medical care of patients with intestinal failure and difficulty accessing transplant care, the actual number of intestine transplants has declined by 25% over the past 6 years. In light of the small numbers of intestine transplants, many physicians and the lay public are often unaware that this is a therapeutic option. The aim of this review is to describe the current indications, outcomes and advances in the field of intestine transplantation and to explore concerns over future access to this important and life-saving therapy.

  3. Public health services and systems research: current state of finance research. (United States)

    Ingram, Richard C; Bernet, Patrick M; Costich, Julia F


    There is a growing recognition that the US public health system should strive for efficiency-that it should determine the optimal ways to utilize limited resources to improve and protect public health. The field of public health finance research is a critical part of efforts to understand the most efficient ways to use resources. This article discusses the current state of public health finance research through a review of public health finance literature, chronicles important lessons learned from public health finance research to date, discusses the challenges faced by those seeking to conduct financial research on the public health system, and discusses the role of public health finance research in relation to the broader endeavor of Public Health Services and Systems Research.


    Directory of Open Access Journals (Sweden)

    Semenova V. V.


    Full Text Available The article considers data on the stocktaking of plants in the collection of medicinal plants of the Yakut Botanical Garden on the following parameters: the study of the component composition, the inclusion in the Pharmacopoeia articles and the Russian State Register of medicinal products. Introduction test in the collection has been performed for 158 species from 99 genera and 41 families, currently the collection has 101 species from 79 genera and 34 families. Chemical composition of plants is known for 61 species. 17 species are pharmacopoeal and 15 species make medicinal products available. The rest of the medicinal plants can be used in folk medicine. Most represented are Asteraceae family (25, Ranunculaceae (20, Rosaceae (16, Fabaceae (15, Lamiaceae (13, among tested plants. According to the assessment of introduction capabilities, 49 species in the collection are highly stable, 51 - stable and just one is unstable

  5. New Member States of the European Union and the Current Trends in the World Economy

    Directory of Open Access Journals (Sweden)

    Ilya Bolotov


    Full Text Available This paper describes the specifics of the current development of the world economy and discusses implications for new member states of the European Union, the EU NMS, with a small case study on the Czech Republic. The paper is divided into four parts: the trends, the EU NMS and the effects of the trends in the EU NMS and in the Czech Republic. The paper is based on a general economic analysis of data provided by the World Bank (WB, the International Monetary Fund (IMF, Eurostat, the European Central Bank (ECB and by the Czech Statistical Office (CZSO. Being familiar with recent macroeconomic trends is nowadays important for Central and Eastern European managers in order to efficiently adapt their strategies to the constantly changing business environment.

  6. Current limit diagrams for dendrite formation in solid-state electrolytes for Li-ion batteries (United States)

    Raj, R.; Wolfenstine, J.


    We build upon the concept that nucleation of lithium dendrites at the lithium anode-solid state electrolyte interface is instigated by the higher resistance of grain boundaries that raises the local electro-chemical potential of lithium, near the lithium-electrode. This excess electro-chemo-mechanical potential, however, is reduced by the mechanical back stress generated when the dendrite is formed within the electrolyte. These parameters are coalesced into an analytical model that prescribes a specific criterion for dendrite formation. The results are presented in the form of current limit diagrams that show the "safe" and "fail" regimes for battery function. A higher conductivity of the electrolyte can reduce dendrite formation.

  7. The LandScan Global Population Distribution Project: Current State of the Art and Prospective Innovation

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Amy N [ORNL; Bright, Eddie A [ORNL


    Advances in remote sensing, dasymetric mapping techniques, and the ever-increasing availability of spatial datasets have enhanced global human population distribution databases. These datasets demonstrate an enormous improvement over the conventional use of choropleth maps to represent population distribution and are vital for analysis and planning purposes including humanitarian response, disease mapping, risk analysis, and evacuation modeling. Dasymetric mapping techniques have been employed to address spatial mismatch, but also to develop finer resolution population distributions in areas of the world where subnational census data are coarse or non-existent. One such implementation is the LandScan Global model which provides a 30 arc-second global population distribution based on ancillary datasets such as land cover, slope, proximity to roads, and settlement locations. This work will review the current state of the LandScan model, future innovations aimed at increasing spatial and demographic resolution, and situate LandScan within the landscape of other global population distribution datasets.

  8. Current state and prospects of cost accounting enterprises oil and fat industry

    Directory of Open Access Journals (Sweden)

    I.M. Vygivska


    Full Text Available The article analyzes the current state oil and fat industry of Ukraine and described the trend of the industry of agriculture. Revealed the pressing problems of accounting of expenses oil and fat industry, identified cost centers and their composition, raw materials, products and waste as well as the directions of economic activity (of species that cause costs to increase efficiency of resource potential sub the object management capabilities and optimize its financial results. The study singles out areas of improvement of organizational and methodological aspects of the accounting of expenses oil and fat industry, in particular in terms of internal accounting proposed disclosure of costs to activities, types of oil and fat products, cost centers and production waste, contributing optimization of production costs and expenses of the entity as a whole

  9. AC current driven dynamic vortex state in YBa{sub 2}Cu{sub 3}O{sub 7-x}

    Energy Technology Data Exchange (ETDEWEB)

    Lucarelli, A.; Frey, A.; Yang, R.; Luepke, G. [The College of William and Mary, Department of Applied Science, Williamsburg, VA (United States); Grilli, F. [Los Alamos National Laboratory, Superconductivity Technology Center, Los Alamos, NM (United States); Haugan, T.; Levin, G.; Barnes, P. [Air Force Research Laboratory, Wright-Patterson AFB, OH (United States)


    Time-resolved magneto-optical imaging measurements show that an ac current enables the vortex matter in YBa{sub 2}Cu{sub 3}O{sub 7-x} thin films to reorganize into two coexisting steady states of driven vortex motion with different characteristics: a quasi-static disordered glassy state in the sample interior and a dynamic state of plastic motion near the edges. Finite-element calculations consistent with the critical state model show good agreement with the measured field profiles in the quasi-static state but predict a larger hysteretic behavior in the dynamic state. (orig.)

  10. Crowdsourcing, Citizen Science or Volunteered Geographic Information? The Current State of Crowdsourced Geographic Information

    Directory of Open Access Journals (Sweden)

    Linda See


    Full Text Available Citizens are increasingly becoming an important source of geographic information, sometimes entering domains that had until recently been the exclusive realm of authoritative agencies. This activity has a very diverse character as it can, amongst other things, be active or passive, involve spatial or aspatial data and the data provided can be variable in terms of key attributes such as format, description and quality. Unsurprisingly, therefore, there are a variety of terms used to describe data arising from citizens. In this article, the expressions used to describe citizen sensing of geographic information are reviewed and their use over time explored, prior to categorizing them and highlighting key issues in the current state of the subject. The latter involved a review of ~100 Internet sites with particular focus on their thematic topic, the nature of the data and issues such as incentives for contributors. This review suggests that most sites involve active rather than passive contribution, with citizens typically motivated by the desire to aid a worthy cause, often receiving little training. As such, this article provides a snapshot of the role of citizens in crowdsourcing geographic information and a guide to the current status of this rapidly emerging and evolving subject.

  11. Finite current stationary states of random walks on one-dimensional lattices with aperiodic disorder (United States)

    Miki, Hiroshi


    Stationary states of random walks with finite induced drift velocity on one-dimensional lattices with aperiodic disorder are investigated by scaling analysis. Three aperiodic sequences, the Thue-Morse (TM), the paperfolding (PF), and the Rudin-Shapiro (RS) sequences, are used to construct the aperiodic disorder. These are binary sequences, composed of two symbols A and B, and the ratio of the number of As to that of Bs converges to unity in the infinite sequence length limit, but their effects on diffusional behavior are different. For the TM model, the stationary distribution is extended, as in the case without current, and the drift velocity is independent of the system size. For the PF model and the RS model, as the system size increases, the hierarchical and fractal structure and the localized structure, respectively, are broken by a finite current and changed to an extended distribution if the system size becomes larger than a certain threshold value. Correspondingly, the drift velocity is saturated in a large system while in a small system it decreases as the system size increases.

  12. The order Corallinales sensu lato (Rhodophyta in the Iberian Atlantic: current state of knowledge

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    Juan Lugilde


    Full Text Available A review of the order Corallinales sensu lato in the Atlantic Iberian Peninsula is presented with the aim of assessing its current state of knowledge in comparison with adjacent areas (British Isles-Atlantic France, Macaronesia and Iberian Mediterranean. According to the information compiled from more than 250 publications, herbarium data and manuscripts, we concluded that Atlantic Iberian coralline algae have been poorly studied, which resulted in only 49 species reported. By contrast, Macaronesia is the most species-rich region (91, followed by Spanish Mediterranean (67 and the British Isles-Atlantic France (61. In the Atlantic Iberian Peninsula, 17 species occurred commonly (present in more than 50% of the coastline, particularly those corresponding to the genera Amphiroa, Jania, Lithophyllum, Mesophyllum, and Phymatolithon. Instead, the genera Harveylithon, Hydrolithon, Leptophytum, Lithothamnion, Neogoniolithon and Pneophyllum have been occasionally reported. In the Atlantic Iberian Peninsula and adjacent regions, the epilithic growth-form was dominant, followed by the epiphytic, epizoic and the unattached (maerl/rodoliths; besides, sciaphilous taxa were more abundant than photophilous species. The low intertidal and shallow subtidal harbour a high diversity of coralline algae, as well as semi-exposed coasts or areas affected by currents. The present study confirms that studies on the Atlantic Iberian coralline algae are scarce, and that further research on this group is required.

  13. The economic burden of systemic lupus erythematosus in Asia: the current state. (United States)

    Mak, A


    Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory disorder which imposes considerable negative impact on patients' function and quality of life, and it appears to entail substantial loss of work productivity and healthcare cost. Although much has been studied regarding the epidemiology, pathogenesis, disease activity, disease damage and pharmacological treatment of SLE, publications on the economic burden of lupus are scarce. As the majority of lupus patients are residing in the Asia Pacific region where many are financially and socially deprived, and, from what we know from the current literature, work disability of lupus patients in Asia is substantial, cost-of-illness studies on SLE are thus particularly relevant in countries around the region. Reliable data from properly conducted prospective SLE cost studies are imperative for policymakers to efficiently distribute healthcare resources, especially in Asia where limited resources are unable to cope with the huge population. In this paper, we review the current state of cost-of-illness research on lupus in Asia and analyze the reasons why such studies are urgently required in the Asia Pacific region.

  14. A Review of Current Issues in State-of-Art of Wind Farm Overvoltage Protection

    Directory of Open Access Journals (Sweden)

    Ranko Goić


    Full Text Available This paper elaborates on several important outstanding issues in the state-of-art of overvoltage protection selection for modern wind farms. The lack of experience with this still-new technology, together with the inherent complexity of wind farm electrical systems, entails several unresolved issues pertinent to the topic of overvoltage protection, particularly in relation to lightning-initiated surges. Firstly, several aspects of the wind turbine lightning incidence, along with the issues related to the selection of lightning current parameters (pertinent to the wind farm overvoltage protection, are addressed in this paper. Secondly, several issues in the state-of-art models of the wind farm electrical systems—for the lightning surge analysis—are addressed and discussed. Here, a well-known ElectroMagnetic Transients Program (EMTP software package is often employed, with all of its benefits and some limitations. Thirdly, the metal-oxide surge arrester energy capability and the issues related to the selection of the surge arrester rated energy—in relation to the direct lightning strikes to wind turbines—is addressed. Finally, some general considerations concerning the overvoltage protection selection for wind farm projects, particularly regarding the installation of the metal-oxide surge arresters, are provided as well.

  15. Research on the Current Telecommuting Trends in United States and European Union Markets

    Directory of Open Access Journals (Sweden)

    Catalina Georgiana PICU


    Full Text Available In the context of globalization and due to the accelerated progress made in information and communication technology, more and more companies offer their employees the option of telecommuting. For the past twenty years, telecommuting has been on an asceding trend, an incresing number of people embracing the ability to work from home, using a computer and internet connection to communicate for their jobs. The goal of the paper is to explain the overall notion of telecommuting and to analyze the current trends in the United States and European Union markets. Another objective is to assess the advantages and disadvantages of telecommuting and the important role played by this concept within the striving purpose of corporations to achieve their strategic targets. The study is based upon specialized literature reviews regarding the emergence of telecommuting and the role it plays in organizations. A comparative analysis was conducted by the authors on two regional markets, United States and the European Union, in order to assess the trend in telecommuting and the factors that influence it. The outcome of the research shows that although the benefits of telecommuting are numerous, it does not come without challenges, both being applicable for both the employer, as well as for the employee. The research results of this study can be used by organizations when considering to offer their employees flexible work opportunities which can positively influence the long term business performance.

  16. Progress toward steady-state tokamak operation exploiting the high bootstrap current fraction regime (United States)

    Ren, Q. L.; Garofalo, A. M.; Gong, X. Z.; Holcomb, C. T.; Lao, L. L.; McKee, G. R.; Meneghini, O.; Staebler, G. M.; Grierson, B. A.; Qian, J. P.; Solomon, W. M.; Turnbull, A. D.; Holland, C.; Guo, W. F.; Ding, S. Y.; Pan, C. K.; Xu, G. S.; Wan, B. N.


    Recent DIII-D experiments have increased the normalized fusion performance of the high bootstrap current fraction tokamak regime toward reactor-relevant steady state operation. The experiments, conducted by a joint team of researchers from the DIII-D and EAST tokamaks, developed a fully noninductive scenario that could be extended on EAST to a demonstration of long pulse steady-state tokamak operation. Improved understanding of scenario stability has led to the achievement of very high values of βp and βN , despite strong internal transport barriers. Good confinement has been achieved with reduced toroidal rotation. These high βp plasmas challenge the energy transport understanding, especially in the electron energy channel. A new turbulent transport model, named TGLF-SAT1, has been developed which improves the transport prediction. Experiments extending results to long pulse on EAST, based on the physics basis developed at DIII-D, have been conducted. More investigations will be carried out on EAST with more additional auxiliary power to come online in the near term.

  17. Comprehensive estimation model of MERGE: adaptation to current state of world economy

    Directory of Open Access Journals (Sweden)

    Boris Vadimovich Digas


    Full Text Available The optimizing interdisciplinary MERGE model meant mainly for quantitative estimation of outcomes of various nature protection strategy is one of the tools used for studying the climate change problems. Components of a model are the economical and power module, climatic module and module of damage assessment. The main attention in work is paid to the MERGE model adaptation to a world economy current state, and analysis of possible trajectories of economic development of Russia and studying of consequences of country participation in initiatives for emission abatement of greenhouse gases at the various assumptions on dynamics of regional economic and power indicators. As a source of model scenarios of development of the Russian economy, the forecast of long-term socioeconomic development of the country for the period up to 2030 is used. They made by the Ministry of Economic Development of the Russian Federation (namely, the conservative, innovative and forced scenarios defined by different models of state policy for ensuring macroeconomic balance are considered

  18. AAPM/SNMMI Joint Task Force: report on the current state of nuclear medicine physics training. (United States)

    Harkness, Beth A; Allison, Jerry D; Clements, Jessica B; Coffey, Charles W; Fahey, Frederic H; Gress, Dustin A; Kinahan, Paul E; Nickoloff, Edward L; Mawlawi, Osama R; MacDougall, Robert D; Pizzutiello, Robert J


    The American Association of Physicists in Medicine (AAPM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) recognized the need for a review of the current state of nuclear  medicine physics training and the need to explore pathways for improving nuclear medicine physics training opportunities. For these reasons, the two organizations formed a joint AAPM/SNMMI Ad Hoc Task Force on Nuclear Medicine Physics  Training. The mission of this task force was to assemble a representative group of stakeholders to:• Estimate the demand for board-certified nuclear medicine physicists in the next 5-10 years,• Identify the critical issues related to supplying an adequate number of physicists who have received the appropriate level of training in nuclear medicine physics, and• Identify approaches that may be considered to facilitate the training of nuclear medicine physicists.As a result, a task force was appointed and chaired by an active member of both organizations that included representation from the AAPM, SNMMI, the American Board of Radiology (ABR), the American Board of Science in Nuclear Medicine (ABSNM), and the Commission for the Accreditation of Medical Physics Educational Programs (CAMPEP). The Task Force first met at the AAPM Annual Meeting in Charlotte in July 2012 and has met regularly face-to-face, online, and by conference calls. This manuscript reports the findings of the Task Force, as well as recommendations to achieve the stated mission.

  19. Current status of preventive cardiology training among United States cardiology fellowships and comparison to training guidelines. (United States)

    Pack, Quinn R; Keteyian, Steven J; McBride, Patrick E; Weaver, W Douglas; Kim, Henry E


    We evaluated preventive cardiology education in United States cardiology fellowship programs and their adherence to Core Cardiovascular Training Symposium training guidelines, which recommend 1 month of training, faculty with expertise, and clinical experience in cardiac rehabilitation, lipid disorder management, and diabetes management as a part of the prevention curricula. We sent an anonymous survey to United States cardiology program directors and their chief fellow. The survey assessed the program curricula, rotation structure, faculty expertise, obstacles, and recommended improvements. The results revealed that 24% of surveyed programs met the Core Cardiovascular Training Symposium guidelines with a dedicated 1-month rotation in preventive cardiology, 24% had no formalized training in preventive cardiology, and 30% had no faculty with expertise in preventive cardiology, which correlated with fewer rotations in prevention than those with specialized faculty (p = 0.009). Fellows rotated though the following experiences (% of programs): cardiac rehabilitation, 71%; lipid management, 37%; hypertension, 15%; diabetes, 7%; weight management/obesity, 6%; cardiac nutrition, 6%; and smoking cessation, 5%. The program directors cited "lack of time" as the greatest obstacle to providing preventive cardiology training and the chief fellows reported "lack of a developed curriculum" (p = 0.01). The most recommended improvement was for the American College of Cardiology to develop a web-based curriculum/module. In conclusion, most surveyed United States cardiology training programs currently do not adhere to basic preventive cardiovascular medicine Core Cardiovascular Training Symposium recommendations. Additional attention to developing curricular content and structure, including the creation of an American College of Cardiology on-line knowledge module might improve fellowship training in preventive cardiology.

  20. Current status of solid waste management in small island developing states: A review

    Energy Technology Data Exchange (ETDEWEB)

    Mohee, Romeela [University of Mauritius, Réduit (Mauritius); Mauthoor, Sumayya, E-mail: [Department of Chemical & Environmental Engineering, University of Mauritius, Réduit (Mauritius); Bundhoo, Zumar M.A.; Somaroo, Geeta; Soobhany, Nuhaa; Gunasee, Sanjana [Department of Chemical & Environmental Engineering, University of Mauritius, Réduit (Mauritius)


    Highlights: • Waste management is a matter of great concern for small island developing states. • On average, waste generation rate in these islands amounts to 1.29 kg/capita/day. • Illegal dumping and landfilling prevail in most small island developing states. • Sustainable waste management practices, previously absent, are now emerging. • However, many challenges still hinder the implementation of these practices. - Abstract: This article reviews the current status of waste management in Small Island Developing States (SIDS) and the challenges that are faced in solid waste management. The waste generation rates of SIDS were compared within the three geographic regions namely Caribbean SIDS, Pacific SIDS and Atlantic, Indian Ocean, Mediterranean and South China (AIMS) SIDS and with countries of the Organisation for Economic Co-Operation and Development (OECD). Only Pacific SIDS had a waste generation rate less than 1 kg/capita/day. The waste generation rates for the three SIDS regions averaged 1.29 kg/capita/day while that for OECD countries was at a mean value of 1.35 kg/capita/day. The waste compositions in the different SIDS regions were almost similar owing to comparable consumption patterns while these differed to a large extent with wastes generated in OECD countries. In SIDS, the major fraction of MSW comprised of organics (44%) followed by recyclables namely paper, plastics, glass and metals (total: 43%). In contrast, MSW in OECD countries consisted mainly of recyclables (43%) followed by organics (37%). This article also reviewed the other functional elements of the waste management systems in SIDS. Several shortcomings were noted in the process of waste collection, transfer and transport namely the fact of having outdated collection vehicles and narrow roads which are inaccessible. Among the waste management practices in SIDS, waste disposal via landfilling, illegal dumping and backyard burning were favoured most of the time at the expense of

  1. A new current line division concept for the determination of the current distribution in electrochemical cells. Part I. Theoretical background of the “corner weakness” effect in electroforming

    Directory of Open Access Journals (Sweden)



    Full Text Available A new approach to the determination of the current distribution in electrochemical cells, the current line division concept, is introduced. The new concept, based on the basic equations of electrics and electrochemical kinetics, was employed for a theoretical explanation of the phenomenon known in electroforming as “corner weakness”. It was shown that this phenomenon depends on the kind of control of the deposition process, being the largest in the case of pure ohmic control and disappearing in the case of pure activation control.

  2. Current state of chronic wound care in Kazakhstan: focus on topical treatments

    Directory of Open Access Journals (Sweden)

    Alma Akhmetova


    Full Text Available Background — The presence of chronic hard-to-heal wounds significantly affects patients’ quality of life causing pain, discomfort, decrease of mobility and consequently leads to social isolation and depression. This type of wound is more prevalent among older population. It has been estimated that up to 1-2% of the world population have this condition. The treatment of hard-to-heal wounds is expensive and long-term process, and, stresses healthcare systems of every country. Unfortunately, limited information is available about the situation with chronic wounds in Kazakhstan as the statistical data on such patients is not monitored and not registered in this country. Methods — The search was conducted by using available electronic sources, including Google Scholar, PubMed, Web of Sciences, Medline, Wiley Online Library, and Cochrane Library databases as well as hard copy versions of peer-reviewed publications in Russian, Kazakh, and English languages. Results — We have identified and analyzed current situation with wound care in the Republic of Kazakhstan. Research has demonstrated a variety of types of treatments utilized in the country, particularly the treatment of the diabetic foot.It also indicates the lack of statistics on wound care. Conclusions — The review highlights the mechanisms of wound healing process, methods for wound care, and encompasses the information available on wound healing in Republic of Kazakhstan. The article emphasizes the necessity of establishing the systemic monitoring of wound care and formation of electronic database. Apart from that, the importance of developing and manufacturing of domestic novel wound treatments have been also stressed out.

  3. Individual Differences and State-Dependent Responses in Transcranial Direct Current Stimulation. (United States)

    Hsu, Tzu-Yu; Juan, Chi-Hung; Tseng, Philip


    Transcranial direct current stimulation (tDCS) has been extensively used to examine whether neural activities can be selectively increased or decreased with manipulations of current polarity. Recently, the field has reevaluated the traditional anodal-increase and cathodal-decrease assumption due to the growing number of mixed findings that report the effects of the opposite directions. Therefore, the directionality of tDCS polarities and how it affects each individual still remain unclear. In this study, we used a visual working memory (VWM) paradigm and systematically manipulated tDCS polarities, types of different independent baseline measures, and task difficulty to investigate how these factors interact to determine the outcome effect of tDCS. We observed that only low-performers, as defined by their no-tDCS corsi block tapping (CBT) performance, persistently showed a decrement in VWM performance after anodal stimulation, whereas no tDCS effect was found when participants were divided by their performance in digit span. In addition, only the optimal level of task difficulty revealed any significant tDCS effect. All these findings were consistent across different blocks, suggesting that the tDCS effect was stable across a short period of time. Lastly, there was a high degree of intra-individual consistency in one's responsiveness to tDCS, namely that participants who showed positive or negative effect to anodal stimulation are also more likely to show the same direction of effects for cathodal stimulation. Together, these findings imply that tDCS effect is interactive and state dependent: task difficulty and consistent individual differences modulate one's responsiveness to tDCS, while researchers' choices of independent behavioral baseline measures can also critically affect how the effect of tDCS is evaluated. These factors together are likely the key contributors to the wide range of "noises" in tDCS effects between individuals, between stimulation protocols

  4. Automated glycopeptide analysis--review of current state and future directions. (United States)

    Dallas, David C; Martin, William F; Hua, Serenus; German, J Bruce


    Glycosylation of proteins is involved in immune defense, cell-cell adhesion, cellular recognition and pathogen binding and is one of the most common and complex post-translational modifications. Science is still struggling to assign detailed mechanisms and functions to this form of conjugation. Even the structural analysis of glycoproteins-glycoproteomics-remains in its infancy due to the scarcity of high-throughput analytical platforms capable of determining glycopeptide composition and structure, especially platforms for complex biological mixtures. Glycopeptide composition and structure can be determined with high mass-accuracy mass spectrometry, particularly when combined with chromatographic separation, but the sheer volume of generated data necessitates computational software for interpretation. This review discusses the current state of glycopeptide assignment software-advances made to date and issues that remain to be addressed. The various software and algorithms developed so far provide important insights into glycoproteomics. However, there is currently no freely available software that can analyze spectral data in batch and unambiguously determine glycopeptide compositions for N- and O-linked glycopeptides from relevant biological sources such as human milk and serum. Few programs are capable of aiding in structural determination of the glycan component. To significantly advance the field of glycoproteomics, analytical software and algorithms are required that: (i) solve for both N- and O-linked glycopeptide compositions, structures and glycosites in biological mixtures; (ii) are high-throughput and process data in batches; (iii) can interpret mass spectral data from a variety of sources and (iv) are open source and freely available.

  5. Current state, habitat and potential invasiveness of Montia linearis (Douglas ex Hook. Greene in Poland

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    Iwona Dembicz


    Full Text Available Montia linearis is a vascular plant originating from western North America. The expansion of this species has been observed for several decades. For the first time M. linearis was found in Europe in 1989. Further six populations were documented by 2004 within the continent: three in Poland, two in Denmark and one in Hungary. Apart from discovering a new population of M. linearis, we confirmed two out of the three previously known localities of the species in Poland. All the currently known populations of M. linearis occupied predominantly meadow habitats, especially intensively managed sites. Some individuals were also found in disturbed sites with bare soil. The studied species inhabited soils of various types with broad range of fertility as well as humidity. Montia linearis populations reached densities up to 87 individuals per 0.04 m2. The number of seeds produced by an individual was between 10 and 55 in 90% of the studied specimens, however much more fertile specimens were also observed. As the previously presented hypothesis of M. linearis dispersal with rail transport seemed not to be well supported, the connection between the M. linearis presence and cattle husbandry is considered. It is possible that the species can be transferred with living animals or manure. The species was able to survive for at least 26 years within once inhabited site. Further spread of M. linearis within Europe is highly probable. The aim of the study is to: (i describe the current state of populations of M. linearis in Poland, (ii provide information on habitat preferences and biology of the species, (iii assess the invasiveness potential of M. linearis in Poland.

  6. Vitamin D and chronic diseases: the current state of the art. (United States)

    Muscogiuri, Giovanna; Altieri, Barbara; Annweiler, Cedric; Balercia, Giancarlo; Pal, H B; Boucher, Barbara J; Cannell, John J; Foresta, Carlo; Grübler, Martin R; Kotsa, Kalliopi; Mascitelli, Luca; März, Winfried; Orio, Francesco; Pilz, Stefan; Tirabassi, Giacomo; Colao, Annamaria


    The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document's topic that was subjected to voting by all experts as "yes" (agreement with the content and/or wording) or "no" (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.

  7. Spin-up, adjustment and equilibrium state of the Antarctic Circumpolar Current (United States)

    Johnson, H. L.; Allison, L. C.; Marshall, D. P.; Munday, D. R.


    An analytical model will be presented for the spin-up, adjustment and equilibrium state of the Antarctic Circumpolar Current (ACC) in a reduced-gravity ocean, forced by wind stress, buoyancy forcing and diapycnal mixing. The initial spin-up from a shallow pycnocline (consistent with Sandstrom's theorem) is controlled by diapycnal mixing, but the eventual equilibration/adjustment time-scale is controlled by the Gent and McWilliams eddy transfer coefficient. This has important implications for climate model studies, which greatly underestimate the sensitivity of eddy fluxes to changes in the mean strength of the ACC. We also find that diapycnal mixing plays an important role in setting the mean strength of the ACC, in particular in the limit of strong diapycnal mixing (10-4 m2 s-1). This is for precisely the same reasons that diapycnal mixing may be important in setting the strength of the Atlantic Meridional Overturning Circulation (AMOC). The theoretical predictions are compared with the results of numerical calculations carried out with the MITgcm, in a global configuration with parameterized eddies, and in an idealized basin/re-entrant channel configuration with partially resolved eddies. The relationship between ACC adjustment, the global pycnocline and the AMOC, as well as the possibility of exciting seiching modes between the different basins, will also be discussed.

  8. Crash data quality for road safety research: Current state and future directions. (United States)

    Imprialou, Marianna; Quddus, Mohammed


    Crash databases are one of the primary data sources for road safety research. Therefore, their quality is fundamental for the accuracy of crash analyses and, consequently the design of effective countermeasures. Although crash data often suffer from correctness and completeness issues, these are rarely discussed or addressed in crash analyses. Crash reports aim to answer the five "W" questions (i.e. When?, Where?, What?, Who? and Why?) of each crash by including a range of attributes. This paper reviews current literature on the state of crash data quality for each of these questions separately. The most serious data quality issues appear to be: inaccuracies in crash location and time, difficulties in data linkage (e.g. with traffic data) due to inconsistencies in databases, severity misclassification, inaccuracies and incompleteness of involved users' demographics and inaccurate identification of crash contributory factors. It is shown that the extent and the severity of data quality issues are not equal between attributes and the level of impact in road safety analyses is not yet entirely known. This paper highlights areas that require further research and provides some suggestions for the development of intelligent crash reporting systems.

  9. Current epidemiological status of schistosomiasis in the state of Pernambuco, Brazil. (United States)

    Barbosa, Constança Simões; Araújo, Karina Conceição; Sevilla, Manuel Alexander Amarista; Melo, Fabio; Gomes, Elainne Christine de Souza; Souza-Santos, Reinaldo


    Uncontrolled peripheral urbanisation coupled with environmental degradation has affected the status of schistosomiasis in Pernambuco (PE), Brazil. This endemic disease continues to perpetuate its transmission in rural areas and has also become a cause for concern in coastal towns of the state. The lack of basic infrastructure (sanitation and health programmes) to support the new urban areas leads to faecal contamination of natural aquatic environments, resulting in consequent infection of vector snails and the emergence of new sources of schistosomiasis transmission. In the present paper, we discuss the current epidemiological status of schistosomiasis in PE. We have consolidated and analysed information from parasitological, malacological and morbidity surveys undertaken by the group of researchers at the Laboratory of Schistosomiasis, Centro de Pesquisas Aggeu Magalhães-Fiocruz. The results of our analysis show: (i) the maintenance of the levels of schistosomiasis in the rural Zona da Mata, PE, (ii) the record of the human cases of schistosomiasis and the foci of infected snails detected along the coast of PE through 2007, (iii) the high record of the severe clinical form of schistosomiasis in the metropolitan region of Recife (RMR) and (iv) new breeding sites of schistosomiasis vector snails that were identified in a 2008 survey covering the RMR and the coastal localities of PE.

  10. Advances in hepatitis C therapy: What is the current state - what come’s next? (United States)

    Zopf, Steffen; Kremer, Andreas E; Neurath, Markus F; Siebler, Juergen


    Chronic hepatitis C virus (HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease. It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin. However, treatment of HCV has undergone a revolutionary change in recent years. The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents (DAA). Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure. High rates of sustained virological response (SVR) rates can be achieved with these novel drugs. Even in difficult to treat populations such as patients with liver cirrhosis, HCV-human immunodeficiency virus co-infections, after liver transplantion, or with chronic kidney disease comparable high rates of SVR can be achieved. The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or post-transplant patients. These 2nd generations DAAs will have higher resistance barriers, higher antiviral effects and a pan-genotypic spectrum. This review highlights the current state of the art of antiviral treatment in hepatitis C and gives an outlook for upcoming therapies. PMID:26839638

  11. The current format and ongoing advances of medical education in the United States. (United States)

    Gishen, Kriya; Ovadia, Steven; Arzillo, Samantha; Avashia, Yash; Thaller, Seth R


    The objective of this study was to examine the current system of medical education along with the advances that are being made to support the demands of a changing health care system. American medical education must reform to anticipate the future needs of a changing health care system. Since the dramatic transformations to medical education that followed the publication of the Flexner report in 1910, medical education in the United States has largely remained unaltered. Today, the education of future physicians is undergoing modifications at all levels: premedical education, medical school, and residency training. Advances are being made with respect to curriculum design and content, standardized testing, and accreditation milestones. Fields such as plastic surgery are taking strides toward improving resident training as the next accreditation system is established. To promote more efficacious medical education, the American Medical Association has provided grants for innovations in education. Likewise, the Accreditation Council for Graduate Medical Education outlined 6 core competencies to standardize the educational goals of residency training. Such efforts are likely to improve the education of future physicians so that they are able to meet the future needs of American health care.


    Directory of Open Access Journals (Sweden)

    Yulia Hafizovna DAVYDOVA


    Full Text Available The article highlights the current state of the legislation on protection of the rights of under-aged. Much attention is paid to the formation of the juvenile justice system in the Russian Federation. We present problems related to law infringements by teenagers in various fields and their solutions, highlight the work and the development of juvenile courts in Russia, sum up the results of the implementation of juvenile technologies and their significance, gives the definition of the term «confiscation» of the child, which in accordance with the Family Code is replaced by the «restriction of parental rights». The article considers the cases when the guardianship and trusteeship bodies deprived parents of their children because of their «oppressive love» to the child or because they could not buy more «fashionable» clothes, and stresses the idea that it is inadmissible to deprive children of their family without serious reasons, such as a threat to their life or health. This issue must be given proper public attention; otherwise it can lead to destruction of the family. The article suggests various measures and recommendations for the reform of the judicial system and its adaptation for juveniles, including protection of the rights of disabled children and protection of children from alcohol, drug abuse, and violence. 


    Directory of Open Access Journals (Sweden)

    Klimova N. V.


    Full Text Available The crediting activity of commercial banks is a precondition for successful competition of these institutions which leads to the increase in production of credited organizations, employment growth and solvency improvement of the participants of economic relations. Not only the improvement of the crediting technology is considered but also the development and the introduction of new methods of reducing crediting risks are observed. The realization of the small business potential in solving economic and social problems is absolutely impossible without its adequate financial and crediting support. In contemporary Russia the problem of financial support of small business development is particularly urgent. The need for crediting and development of small business in Russia is discussed in this article. The analysis of the main indicators characterizing the current state of crediting of small and medium-sized businesses is made, the SWOT-credit rating is given and the rating of banks providing loans to small business is shown. The main indicators of small and medium-sized business were considered, the analysis of the dynamics of the volume of loans provided to small business was made and the size of loan portfolios was discussed. The main reasons why banks refuse to lend to small business are ranked. On the basis of findings, the ways of solving the problem, in particular the reduction of the tax burden on small business, fixing the prices for the conclusion of contracts and the development of credit bureaus, are suggested.

  14. Carotid artery stenosis. Current state of therapy; Karotisstenose. Aktueller Stand der Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, K.I.; Papanagiotou, P.; Zimmer, A.; Reith, W. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany); Schaefers, H.J. [Universitaetsklinikum des Saarlandes, Klinik fuer Thorax- und Herz-Gefaess-Chirurgie, Homburg/Saar (Germany)


    Ipsilateral occlusive or embolizing carotid artery stenoses are found in 20-30% of all cases of ischemic stroke. Several randomized studies revealed endarterectomy to be the gold standard in the therapy of severe symptomatic (NASCET, ESCT) and to some extent of asymptomatic carotid stenoses (ACAS, ACST). Stent angioplasty has been established as an alternative therapeutic option although non-inferiority of this procedure has not yet been proven. We provide an overview of both procedures as well of the state of current trials. (orig.) [German] Okkludierende oder embolisierende Stenosen der A. carotis interna sind in 20-30% der Faelle fuer einen ipsilateralen ischaemischen Schlaganfall verantwortlich. Nach Abschluss mehrerer randomisierter Studien erscheint die Karotisendarteriektomie als Therapie der Wahl bei hochgradigen symptomatischen (NASCET, ESCT) und z. T. auch asymptomatischen Stenosen (ACAS, ACST). Seit einigen Jahren hat sich die (Stent-)Angioplastie zunehmend als Therapiealternative etabliert, auch wenn die bislang veroeffentlichten Studien die Gleichwertigkeit beider Verfahren noch nicht zeigen konnten. Wir geben einen Ueberblick ueber beide Verfahren sowie ueber die derzeitige Studienlage. (orig.)

  15. Current State Overview of the Vama Veche - 2 Mai Marine Reserve, Black Sea, Romania

    Directory of Open Access Journals (Sweden)

    Victor Niţă


    Full Text Available The Vama Veche - 2 Mai marine area is an almost unique combination at the Romanian coast, covering a wide variety of elementaryhabitats, the area being considered a true mosaic. The extremely rich benthic and pelagic life, expressed by the high biodiversity in the area, isa real milestone for the Romanian coast, being at the same time shelter and breeding area for many nektonic marine organisms. The NationalInstitute for Marine Research and Development “Grigore Antipa“ Constanta was custodian of the reserve in the period 2004 - 2009, duringwhich an intense research activity was developed in the area, evidenced by the numerous scientific papers published, as well as the ManagementPlan and Regulation of the Reserve, completed and submitted for approval to the Ministry of Environment. Since December 2011, the Institutehas again taken into custody the Vama Veche Reserve, for a period of five years. The paper herein is a brief scan of the current state of the protectedarea, based mainly on the research conducted there by the Institute, within many projects focusing on the quality of the Romanian marineenvironment.

  16. Mixing state and sources of submicron regional background aerosols in the northern Qinghai-Tibet Plateau and the influence of biomass burning (United States)

    Li, W. J.; Chen, S. R.; Xu, Y. S.; Guo, X. C.; Sun, Y. L.; Yang, X. Y.; Wang, Z. F.; Zhao, X. D.; Chen, J. M.; Wang, W. X.


    Transmission electron microscopy (TEM) was employed to obtain morphology, size, composition, and mixing state of background aerosols with diameter less than 1 μm in the northern Qinghai-Tibet Plateau (QTP) during 15 September to 15 October 2013. Individual aerosol particles mainly contained secondary inorganic aerosols (SIA - sulfate and nitrate) and organics during clean periods (PM2.5 mass concentration less than 2.5 μg m-3). The presence of K-Na-Cl associated with organics and an increase in soot particles suggest that an intense biomass burning event caused the highest PM2.5 concentrations (> 30 μg m-3) during the study. A large number fraction of the fly-ash-containing particles (21.73 %) suggests that coal combustion emissions in the QTP significantly contributed to air pollutants at the medium pollution level (PM2.5: 10-30 μg m-3). We concluded that emissions from biomass burning and from coal combustion both constantly contribute to anthropogenic particles in the QTP atmosphere. Based on size distributions of individual particles at different pollution levels, we found that gas condensation on existing particles is an important chemical process for the formation of SIA with organic coating. TEM observations show that refractory aerosols (e.g., soot, fly ash, and visible organic particles) likely adhere to the surface of SIA particles larger than 200 nm due to coagulation. Organic coating and soot on surface of the aged particles likely influence their hygroscopic and optical properties, respectively, in the QTP. To our knowledge, this study reports the first microscopic analysis of fine particles in the background QTP air.

  17. Current state and prospects of carbon management in high latitudes of Northern Eurasia (United States)

    Schepaschenko, Dmitry; Shvidenko, Anatoly


    The current state and trajectories of future development of natural landscapes in high latitudes of Northern Eurasia are defined inter alia by (1) current unsatisfactory social and economic situation in boreal Northern Eurasia; (2) the dramatic magnitude of on-going and expected climatic change (warming up to 10-12oC under global warming at 4oC); (3) increasing anthropogenic pressure, particularly in regions of intensive oil and gas exploration and extraction; (4) large areas of sparsely populated and practically unmanaged land; (5) vulnerability of northern ecosystems which historically developed under cold climates and buffering capacity of which is not well known; (6) risk of catastrophic natural disturbances (fire, insect outbreaks) whose frequency and severity have accelerated during recent decades; and (7) high probability of irreversible changes of vegetation cover. These specifics are overlapped with insufficient governance of natural renewable resources (e.g., forests) and destructed practice of industrial development of new territories (oil and gas extraction and exploration, metallurgy etc.). Based on a full carbon account for terrestrial vegetation ecosystems of Northern Eurasia, we analyze the relative impacts of major drivers on magnitude and uncertainty of the Net Ecosystem Carbon Balance (NECB) under current and expected climate and environment. Dynamic trends and interannual variability of NECB are mostly dependent on weather conditions during growth seasons of individual years, regimes of natural disturbances, and anthropogenic impacts on ecosystems. In a short term, disturbances and human impacts cause a theoretically 'manageable' part of the full carbon account, which on average is estimated to be of about 20% of annual net primary production. In a long term, thawing of permafrost and change of hydrological regimes of vast territories may result in a catastrophic decline of the forested area and wide distribution of 'green desertification'. The

  18. Current State of Terminology in Lithuania: Scientific Research, Management and Education

    Directory of Open Access Journals (Sweden)

    Albina Auksoriūtė


    Full Text Available Current State of Terminology in Lithuania: Scientific Research, Management and Education The article discusses the current state of terminology in Lithuania, presents terminological research carried out in the last five years, analyses ways of Lithuanian terminology management, and briefly overviews terminological education and teaching in Lithuania. Lithuanian terminological research is mostly carried out at the Institute of the Lithuanian Language and at universities and other research institutes. The largest part of terminological research is carried out at the Centre of Terminology of the Institute of the Lithuanian Language, which researches Lithuanian terminology and terminography, analyses the use of Lithuanian terminology in different fields. Three ways of terminology management are discussed: terminography, creation of term banks and databases and standardisation of terms. The number of term dictionaries published in Lithuania is rather considerable – over 600. The most productive period for publishing term dictionaries is from 1990 up to date. Between 1990–2013 more than 420 term dictionaries and special encyclopaedias were published. The main and most important terminology database in Lithuania is the Term Bank of the Republic of Lithuania (lt Lietuvos Respublikos terminų bankas, further – LTB, initiated in 2004. This bank is created as a common information system of state institutions administered by the State Commission of the Lithuanian Language (further – Language Commission. There are more than 237,000 term entries in LTB. The article discusses two more terminology databases containing Lithuanian terminology sources – IATE and EUROTERMBANK. The Lithuanian Standards Board, in addition to other work, prepares Lithuanian standards of terms and offers these terms to the Language Commission for evaluation. Since 2000, the Lithuanian Standards Board has been creating a database of standardised terms which currently contains

  19. Overview of current marine juvenile salmon research by the United States (United States)

    Helle, John H.; Eisner, L.B.; Farley, Edward V.; Martinson, Ellen C.; Martinson, Angela; Moss, Jamal H.; Murphy, James M.; Orsi, Joseph A.; Sturdevant, Mollly V.; Wertheimer, Alex C.; Wing, Bruce L.; Brodeur, R.D.; Emmett, Robert; Bucher, Cynthia; MacFarlane, Bruce; Harding, Jeff; Ammann, Arnold; Zimmerman, Christian E.


    A history of juvenile salmon research on Pacific salmon in coastal areas conducted by the United States (U.S.) was published by Brodeur et al. (2003). Presently, juvenile Pacific salmon research in the U.S. occurs in the coastal areas of all of the Pacific states: California, Oregon, Washington, and Alaska (Fig. 1). Major objectives of this research are to understand how dynamics in marine ecosystems influence migration, distribution, growth, and survival of juvenile salmon during their early ocean residence. Several large-scale studies in coastal areas from California to Alaska are currently being conducted by the National Oceanic and Atmospheric Administration (NOAA), National Marine Fisheries Service (NMFS), in collaboration with university and state scientists. Studies off California are operated by the Southwest Fisheries Science Center, Santa Cruz Laboratory in Santa Cruz, California and University of California Santa Cruz. Studies off Oregon and Washington are operated by the Northwest Fisheries Science Center, Newport Laboratory and Oregon State University in Newport, Oregon. Studies in the Gulf of Alaska, Bering Sea and in the seaward migration corridors in the coastal waters of southeastern Alaska are operated by the Alaska Fisheries Science Center, Auke Bay Laboratory in Juneau, Alaska, in collaboration with Alaska Department of Fish and Game, University of Alaska Fairbanks, Bering Sea Fishermen’s Association, and Yukon River Drainage Fishermen’s Association. In addition to these large studies, smaller estuarine studies on juvenile salmon occur in northwestern Alaska in Kuskokwim Bay by the U.S. Geological Survey (Anchorage) and University of Alaska Fairbanks (Juneau), and, in Norton Sound by LGL Alaska Research Associates and Norton Sound Economic Development Corporation both headquartered in Anchorage (Fig. 1). The estuarine studies on juvenile salmon in Alaska operate in shallow water and a variety of gear is used to capture salmon. A small trawl

  20. The reaction current distribution in battery electrode materials revealed by XPS-based state-of-charge mapping. (United States)

    Pearse, Alexander J; Gillette, Eleanor; Lee, Sang Bok; Rubloff, Gary W


    Morphologically complex electrochemical systems such as composite or nanostructured lithium ion battery electrodes exhibit spatially inhomogeneous internal current distributions, particularly when driven at high total currents, due to resistances in the electrodes and electrolyte, distributions of diffusion path lengths, and nonlinear current-voltage characteristics. Measuring and controlling these distributions is interesting from both an engineering standpoint, as nonhomogenous currents lead to lower utilization of electrode material, as well as from a fundamental standpoint, as comparisons between theory and experiment are relatively scarce. Here we describe a new approach using a deliberately simple model battery electrode to examine the current distribution in a electrode material limited by poor electronic conductivity. We utilize quantitative spatially resolved X-ray photoelectron spectroscopy to measure the spatial distribution of the state-of-charge of a V2O5 model electrode as a proxy measure for the current distribution on electrodes discharged at varying current densities. We show that the current at the electrode-electrolyte interface falls off with distance from the current collector, and that the current distribution is a strong function of total current. We compare the observed distributions with a simple analytical model which reproduces the dependence of the distribution on total current, but fails to predict the correct length scale. A more complete numerical simulation suggests that dynamic changes in the electronic conductivity of the V2O5 concurrent with lithium insertion may contribute to the differences between theory and experiment. Our observations should help inform design criteria for future electrode architectures.

  1. A synthesis of current knowledge on forests and carbon storage in the United States. (United States)

    McKinley, Duncan C; Ryan, Michael G; Birdsey, Richard A; Giardina, Christian P; Harmon, Mark E; Heath, Linda S; Houghton, Richard A; Jackson, Robert B; Morrison, James F; Murray, Brian C; Patakl, Diane E; Skog, Kenneth E


    Using forests to mitigate climate change has gained much interest in science and policy discussions. We examine the evidence for carbon benefits, environmental and monetary costs, risks and trade-offs for a variety of activities in three general strategies: (1) land use change to increase forest area (afforestation) and avoid deforestation; (2) carbon management in existing forests; and (3) the use of wood as biomass energy, in place of other building materials, or in wood products for carbon storage. We found that many strategies can increase forest sector carbon mitigation above the current 162-256 Tg C/yr, and that many strategies have co-benefits such as biodiversity, water, and economic opportunities. Each strategy also has trade-offs, risks, and uncertainties including possible leakage, permanence, disturbances, and climate change effects. Because approximately 60% of the carbon lost through deforestation and harvesting from 1700 to 1935 has not yet been recovered and because some strategies store carbon in forest products or use biomass energy, the biological potential for forest sector carbon mitigation is large. Several studies suggest that using these strategies could offset as much as 10-20% of current U.S. fossil fuel emissions. To obtain such large offsets in the United States would require a combination of afforesting up to one-third of cropland or pastureland, using the equivalent of about one-half of the gross annual forest growth for biomass energy, or implementing more intensive management to increase forest growth on one-third of forestland. Such large offsets would require substantial trade-offs, such as lower agricultural production and non-carbon ecosystem services from forests. The effectiveness of activities could be diluted by negative leakage effects and increasing disturbance regimes. Because forest carbon loss contributes to increasing climate risk and because climate change may impede regeneration following disturbance, avoiding

  2. Coal-water slurry fuel production: Its evolution and current status in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, J.L.; Miller, B.G.; Scaroni, A.W. [Pennsylvania State Univ., University Park, PA (United States)


    Interest in the US in utilizing bituminous coal in a slurry form has evolved substantially over the last two decades. In the mid-1970`s, technologies to utilize coal-oil mixtures (COMs) as potential fuel oil replacements for utility and industrial boilers were developed as a consequence of escalating world oil prices. To further reduce dependency on imported oil, interest shifted away from COMs to coal-water slurry fuels (CWSFs) because higher solids loadings were obtainable while eliminating the use of oil. Research which focused on the use of CWSF as a potential fuel oil replacement peaked in the mid to late-1980`s as a result of a decline in world oil prices. During the late 1980`s and early 1990`s, coal suppliers and coal-fired utilities began to evaluate the production of CWSF using bituminous coal fines from fine coal cleaning circuits in an effort to reduce dewatering/drying costs. This marked a philosophical change in the driving force behind the utilization of CWSF in the US. In an effort to broaden the supply of coal fines, The Pennsylvania State University (Penn State) and the Pennsylvania Electric Company (Penelec) surveyed a series of fine coal impoundments in western Pennsylvania to determine the quality, cleanability, and slurryability of the coal fines contained therein. The development and commercialization of recovery technologies, cleaning techniques, and CWSF reentrainment circuits, coupled with an interest by utilities to utilize low-cost fuels, has fostered the recovery of impounded coal fines. In addition to the fine coal impoundments, fine coal cleaning circuits which actively dispose of process water having suspended coal fines (e.g. centrifuge effluent) are being examined to determine if the fines can be recovered and thickened into a low solids CWSF. The paper describes required physical and chemical properties of a CWSF for boiler applications. There is a growing awareness that CWSF is a fuel form that can be cofired with coal. The

  3. Are South African Speech-Language Therapists adequately equipped to assess English Additional Language (EAL) speakers who are from an indigenous linguistic and cultural background? A profile and exploration of the current situation. (United States)

    Mdladlo, Thandeka; Flack, Penelope; Joubert, Robin


    This article presents the results of a survey conducted on Speech-Language Therapists (SLTs) regarding current practices in the assessment of English Additional Language (EAL) speakers in South Africa. It forms part of the rationale for a broader (PhD) study that critiques the use of assessment instruments on EAL speakers from an indigenous linguistic and cultural background. This article discusses an aspect of the broader research and presents the background, method, findings, discussion and implications of the survey. The results of this survey highlight the challenges of human and material resources to, and the dominance of English in, the profession in South Africa. The findings contribute to understanding critical factors for acquiring reliable and valid assessment results with diverse populations, particularly the implications from a cultural and linguistic perspective.

  4. Backgrounder: Final Rule for Current Good Manufacturing ... (United States)

    ... History. ... Tiếng Việt | 한국어 | Tagalog | Русский | العربية | Kreyòl Ayisyen | Français | Polski | Português | Italiano | Deutsch | 日本語 | فارسی | English. ...

  5. The Background to Current Theories of Scuffing (United States)


    but was in fact an oleophobic monolayer of adsorbed polar molecules. The dipper was replaced and the temperature of the solution increased until...182A (1943), 12. BIGELOW, W.C., GLASS, E., ZIZMAN, W.A. Oleophobic Monolayers II, J, Colloid Soc, 1, No.6 (194?). 13. ASKWITH, T.C., CROUCH, R.F

  6. Current state of Czech astronomy popularization and its potential for enhancing science career interest (United States)

    Kříček, Radek


    The Czech Republic has a dense net of observatories, astronomical clubs and other activities for both adults and children. Can we use it to improve skills of our pupils and their motivation to choose their career in science? Does the situation in the Czech Republic differ from abroad? What can we improve in the future? These questions were not answered satisfactorily so far. We decided to contribute to solve this issue.We present our survey of current state based mainly on electronic sources and personal dealings. Besides of 56 observatories working with public and many interest clubs, there are other possibilities to meet astronomy. For example, Astronomical Olympiad attracts thousands of pupils across the country each year to solve both theoretical and practical tasks in astronomy. In other projects, children can visit Dark-Sky Parks, design experiments for a stratospheric balloon, observe with CCD or radio devices or build their own rockets.We outline our ongoing project to examine the link between popularization activities and pupils’ or high school students’ attitude toward science and science career. We plan to create a typology of both popularization activities and life stories of people dealing with astronomy. From the methodological point of view, the mixed method design, combining both the qualitative and quantitative approach, will be used to solve the research problems. The basic research plan will be a case study. So far the project is based on interviews with various subjects. We choose people with different life stories, all connected with astronomy or astronomy popularization in some period. We focus on important moments in their career, similarities between subjects, and various types of possible motivation to participate in astronomy-related activities or to study science at university.Future results can be used to help interested organizations such as universities, observatories or astronomical societies. They will be able to work more

  7. State dependent effect of transcranial direct current stimulation (tDCS) on methamphetamine craving. (United States)

    Shahbabaie, Alireza; Golesorkhi, Mehrshad; Zamanian, Behnam; Ebrahimpoor, Mitra; Keshvari, Fatemeh; Nejati, Vahid; Fregni, Felipe; Ekhtiari, Hamed


    Transcranial direct current stimulation (tDCS) has been shown to modulate subjective craving ratings in drug dependents by modification of cortical excitability in dorsolateral prefrontal cortex (DLPFC). Given the mechanism of craving in methamphetamine (meth) users, we aimed to test whether tDCS of DLPFC could also alter self-reported craving in abstinent meth users while being exposed to meth cues. In this double-blinded, crossover, sham-controlled study, thirty two right-handed abstinent male meth users were recruited. We applied 20 min 'anodal' tDCS (2 mA) or 'sham' tDCS over right DLPFC in a random sequence while subjects performed a computerized cue-induced craving task (CICT) starting after 10 min of stimulation. Immediate craving was assessed before the stimulation, after 10 min of tDCS, and after tDCS termination by visual analog scale (VAS) of 0 to 100. Anodal tDCS of rDLPFC altered craving ratings significantly. We found a significant reduction of craving at rest in real tDCS relative to the sham condition (p = 0.016) after 10 min of stimulation. On the other hand, cue-induced VAS craving was rated significantly higher in the real condition in comparison with sham stimulation (p = 0.012). Our findings showed a state dependent effect of tDCS: while active prefrontal tDCS acutely reduced craving at rest in the abstinent meth users, it increased craving during meth-related cue exposure. These findings reflect the important role of the prefrontal cortex in both cue saliency evaluation and urge to meth consumption.

  8. Genetic considerations for mollusc production in aquaculture: current state of knowledge.

    Directory of Open Access Journals (Sweden)

    Marcela eAstorga


    Full Text Available IIn 2012, world mollusk production in aquaculture reached a volume of 15,171,000 tons, representing 23% of total aquaculture production and positioning mollusks as the second most important category of aquaculture products (fishes are the first. Clams and oysters are the mollusk species with the highest production levels, followed in descending order by mussels, scallops and abalones. In view of the increasing importance attached to genetic information on aquaculture, which can help with good maintenance and thus the sustainability of production, the present work offers a review of the state of knowledge on genetic and genomic information about mollusks produced in aquaculture. The analysis was applied to mollusks which are of importance for aquaculture, with emphasis on the 5 species with the highest production levels. According to FAO, these are: Japanese clam Ruditapes philippinarum; Pacific oyster Crassostrea gigas; Chilean mussel Mytilus chilensis; Blood clam Anadara granosa and Chinese clam Sinonovacula constricta. To date, the genomes of 5 species of mollusks have been sequenced, only one of which, Crassostrea gigas, coincides with the species with the greatest production in aquaculture. Another important species whose genome has been sequenced is Mytilus galloprovincialis, which is the second most important mussel in aquaculture production, after M. chilensis. Few genetic improvement programs have been reported in comparison with the number reported in fish species. The most commonly investigated species are oysters, with at least 5 genetic improvement programs reported, followed by abalones with 2 programs and mussels with one. The results of this work will establish the current situation with respect to the genetics of mollusks which are of importance for aquaculture production, in order to assist future decisions to ensure the sustainability of these resources.

  9. Current status of traditional mental health practice in Ilorin Emirate Council area, Kwara State, Nigeria. (United States)

    Makanjuola, A B; Adelekan, M L; Morakinyo, O


    Twenty-seven traditional mental health practitioners (TMHPs) and 16 patients' relatives (PR) were studied with a view to gaining an understanding of the current status of traditional mental health practice in five local government areas in Ilorin Emirate Council Area, Kwara State, Nigeria. Data was collected using Practitioners' Questionnaire (PQ), Patients' Relatives' Questionnaire (PRQ), Focus Group Discussions (FGDs) and observation of TMHPs in their clinics. Factors which affect utilization of traditional mental health services were also reviewed. We found that TMHPs still enjoy considerable patronage from the populace, are more in numerical strength, and are more widely and evenly dispersed in the community than orthodox mental health practitioners (OMHPs). About 74% of TMHPs expressed interest in attending seminars aimed at improving their skills. Most of the patients' relatives expressed the belief that only traditional healers can understand the supernatural aetiological basis of mental disorders, and can therefore offer more effective care than OMHPs. Some of the negative practices observed were (i) infliction of corporal punishment and physical restraints on patients by some TMHPs resulting in wounds, which often become septic (ii) low level of hygiene at the clinics and (iii) lack of adequate follow-up care. In conclusion, since TMHPs still play a major role in the treatment of the mentally ill in this environment, OMHPs should assist them in improving on some of the negative practices identified. Thus, there is an urgent need to organize a training programme for TMHPs to expose them to the general rules of hygiene in medical care, basic principles of orthodox mental health practice, including human treatment of the mentally ill.

  10. Current status of solid waste management in small island developing states: A review. (United States)

    Mohee, Romeela; Mauthoor, Sumayya; Bundhoo, Zumar M A; Somaroo, Geeta; Soobhany, Nuhaa; Gunasee, Sanjana


    This article reviews the current status of waste management in Small Island Developing States (SIDS) and the challenges that are faced in solid waste management. The waste generation rates of SIDS were compared within the three geographic regions namely Caribbean SIDS, Pacific SIDS and Atlantic, Indian Ocean, Mediterranean and South China (AIMS) SIDS and with countries of the Organisation for Economic Co-Operation and Development (OECD). Only Pacific SIDS had a waste generation rate less than 1kg/capita/day. The waste generation rates for the three SIDS regions averaged 1.29kg/capita/day while that for OECD countries was at a mean value of 1.35kg/capita/day. The waste compositions in the different SIDS regions were almost similar owing to comparable consumption patterns while these differed to a large extent with wastes generated in OECD countries. In SIDS, the major fraction of MSW comprised of organics (44%) followed by recyclables namely paper, plastics, glass and metals (total: 43%). In contrast, MSW in OECD countries consisted mainly of recyclables (43%) followed by organics (37%). This article also reviewed the other functional elements of the waste management systems in SIDS. Several shortcomings were noted in the process of waste collection, transfer and transport namely the fact of having outdated collection vehicles and narrow roads which are inaccessible. Among the waste management practices in SIDS, waste disposal via landfilling, illegal dumping and backyard burning were favoured most of the time at the expense of sustainable waste treatment technologies such as composting, anaerobic digestion and recycling.

  11. Cosmic Tachyon Background Radiation

    CERN Document Server

    Tomaschitz, R


    The equilibrium statistical mechanics of a background radiation of superluminal particles is investigated, based on a vectorial wave equation for tachyons of the Proca type. The partition function, the spectral energy density, and the various thermodynamic variables of an ideal Bose gas of tachyons in an open Robertson-Walker cosmology are derived. The negative mass square in the wave equation changes the frequency scaling in the Rayleigh-Jeans law, and there are also significant changes in the low temperature regime as compared to the microwave background, in particular in the caloric and thermal equations of state.

  12. A Method to Simultaneously Detect the Current Sensor Fault and Estimate the State of Energy for Batteries in Electric Vehicles. (United States)

    Xu, Jun; Wang, Jing; Li, Shiying; Cao, Binggang


    Recently, State of energy (SOE) has become one of the most fundamental parameters for battery management systems in electric vehicles. However, current information is critical in SOE estimation and current sensor is usually utilized to obtain the latest current information. However, if the current sensor fails, the SOE estimation may be confronted with large error. Therefore, this paper attempts to make the following contributions: Current sensor fault detection and SOE estimation method is realized simultaneously. Through using the proportional integral observer (PIO) based method, the current sensor fault could be accurately estimated. By taking advantage of the accurate estimated current sensor fault, the influence caused by the current sensor fault can be eliminated and compensated. As a result, the results of the SOE estimation will be influenced little by the fault. In addition, the simulation and experimental workbench is established to verify the proposed method. The results indicate that the current sensor fault can be estimated accurately. Simultaneously, the SOE can also be estimated accurately and the estimation error is influenced little by the fault. The maximum SOE estimation error is less than 2%, even though the large current error caused by the current sensor fault still exists.

  13. A Method to Simultaneously Detect the Current Sensor Fault and Estimate the State of Energy for Batteries in Electric Vehicles (United States)

    Xu, Jun; Wang, Jing; Li, Shiying; Cao, Binggang


    Recently, State of energy (SOE) has become one of the most fundamental parameters for battery management systems in electric vehicles. However, current information is critical in SOE estimation and current sensor is usually utilized to obtain the latest current information. However, if the current sensor fails, the SOE estimation may be confronted with large error. Therefore, this paper attempts to make the following contributions: Current sensor fault detection and SOE estimation method is realized simultaneously. Through using the proportional integral observer (PIO) based method, the current sensor fault could be accurately estimated. By taking advantage of the accurate estimated current sensor fault, the influence caused by the current sensor fault can be eliminated and compensated. As a result, the results of the SOE estimation will be influenced little by the fault. In addition, the simulation and experimental workbench is established to verify the proposed method. The results indicate that the current sensor fault can be estimated accurately. Simultaneously, the SOE can also be estimated accurately and the estimation error is influenced little by the fault. The maximum SOE estimation error is less than 2%, even though the large current error caused by the current sensor fault still exists. PMID:27548183

  14. Integrating resource efficiency and EU State aid. An evaluation of resource efficiency considerations in the current EU State aid framework

    Energy Technology Data Exchange (ETDEWEB)

    Bennink, D.; Faber, J.; Smit, M. [CE Delft, Delft (Netherlands); Goba, V. [SIA Estonian, Latvian and Lithuanian Environment ELLE, Tallinn (Estonia); Miller, K.; Williams, E. [AEA Technology plc, London (United Kingdom)


    This study, for the European Commission, analyses the issues that need to be addressed in the revision of the EU State aid framework to ensure that they do not hinder environmental, resource efficiency and sustainable development goals. In some cases, State aid can be considered an environmentally harmful subsidy (EHS). The study analyses (1) the extent to which the Environmental Aid Guidelines (EAG) need to be changed to take into account recent European environmental policy developments; (2) existing and potential resource efficiency considerations in a) the Regional Aid Guidelines; b) the Research, Development and Innovation (RDI) Guidelines and c) the Agriculture and Forestry Guidelines; assesses cases and schemes using these guidelines to identify whether resource efficiency considerations are taken into account. The study also considers the social, environmental and economic impacts of these cases and schemes. It develops recommendations for the review of the EAG and a number of horizontal guidelines. One of the conclusions of the analysis is that the way in which multiple objectives and impacts are balanced, when deciding to approve state aid, is unclear. Also, EU member states are not required to provide information on certain types of (estimated) impacts. To guarantee that multiple objectives and impacts are sufficiently balanced, it is recommended that the State aid framework prescribes that applicants identify social, economic and environmental objectives and impacts and describe how these are taken into account in the procedure of balancing multiple (conflicting) objectives. Objectives and impacts should be quantified as much as possible, for example by making use of the method of external cost calculation laid down in 'the Handbook on estimation of external costs in the transport Sector'. The results of the study are used by the European Commission as an input for evaluating and improving the EU State aid framework.

  15. Diagnostics of many-particle electronic states: non-stationary currents and residual charge dynamics (United States)

    Maslova, N. S.; Mantsevich, V. N.; Arseyev, P. I.


    We propose the method for identifying many particle electronic states in the system of coupled quantum dots (impurities) with Coulomb correlations. We demonstrate that different electronic states can be distinguished by the complex analysis of localized charge dynamics and non-stationary characteristics. We show that localized charge time evolution strongly depends on the properties of initial state and analyze different time scales in charge kinetics for initially prepared singlet and triplet states. We reveal the conditions for existence of charge trapping effects governed by the selection rules for electron transitions between the states with different occupation numbers.

  16. Dark current reduction of small molecule organic photodetectors by controlling gap states of molybdenum oxide buffer layers (United States)

    Kim, Seong Heon; Heo, Sung; Yun, Dong-Jin; Satoh, Ryu-ichi; Park, Gyeongsu; Kim, Kyu-Sik


    The gap states of the molybdenum-oxide (MoO x ) hole-extraction layer (HEL) in an organic photodetector (OPD) device, which originate from oxygen-vacancy defects, are controlled by appropriate plasma treatments on the MoO x layer. The density of MoO x gap states, investigated using X-ray photoelectron spectroscopy (XPS), is enhanced and depressed with Ar- and O2-plasma treatments, respectively. The dark current of an OPD with a MoO x HEL is considerably reduced by controlling the MoO x gap states using the plasma-treatment method. The mechanism of dark-current reduction may be interpreted by reduced gap states and by a suitable energy level bending and alignment.

  17. The Cosmic Microwave Background

    Directory of Open Access Journals (Sweden)

    Jones Aled


    Full Text Available We present a brief review of current theory and observations of the cosmic microwave background (CMB. New predictions for cosmological defect theories and an overview of the inflationary theory are discussed. Recent results from various observations of the anisotropies of the microwave background are described and a summary of the proposed experiments is presented. A new analysis technique based on Bayesian statistics that can be used to reconstruct the underlying sky fluctuations is summarised. Current CMB data is used to set some preliminary constraints on the values of fundamental cosmological parameters $Omega$ and $H_circ$ using the maximum likelihood technique. In addition, secondary anisotropies due to the Sunyaev-Zel'dovich effect are described.

  18. A Solid-State Fault Current Limiting Device for VSC-HVDC Systems (United States)

    Larruskain, D. Marene; Zamora, Inmaculada; Abarrategui, , Oihane; Iturregi, Araitz


    Faults in the DC circuit constitute one of the main limitations of voltage source converter VSC-HVDC systems, as the high fault currents can damage seriously the converters. In this article, a new design for a fault current limiter (FCL) is proposed, which is capable of limiting the fault current as well as interrupting it, isolating the DC grid. The operation of the proposed FCL is analysed and verified with the most usual faults that can occur in overhead lines.

  19. Current state and changes of glaciers in the Tavan Bogd Mountains (Mongolia

    Directory of Open Access Journals (Sweden)

    M. V. Syromyatina


    Full Text Available This study is the first stage of detailed investigation of large glaciers located in the Tavan-Bogd Mountains. The main task of this work is to estimate a current state and dynamics of glaciers and to update glacier and rock-glacier inventory. Basing on results of 2013 field survey together with remote sensing data the main glaciers located on eastern slopes of the Tavan Bogd mountain massif in the Tsagan-Us and Tsagan-Gol river basins are described (these glaciers are Potanin, Alexandra, Grane, Kozlov, and Krylov ones. In order to monitor regime of glacier systems the geodetic survey of glaciers and rock-glacier edges was carried out using Trimble GNSS system and the ranging mark system. The Landsat satellite images made taken in August-September of 1989, 2006, and 2013, their spatial resolution 15-30 m, were used to map areas of debris-free glaciers and to estimate the glacier changes between 1989 and 2013. Pictures were taken from the USGS site, the ArcGIS software was used for this work. In addition, the high-resolution satellite pictures with resolution of 0.5–2.5 m made at the end of the ablation season if 2008 (CARTOSAT-1 and 2010 (Geoeye-1 and SPOT-5 were also used to analyze current conditions and changes of the above glaciers and to improve visual estimation of the Landsat imagery. In 2013, the study included 26 glaciers with the debris-free glacier area of 67 km2 in the Tsagan-Gol river basin and 37 glaciers with area of 30 km2 in the Tsagan-Us river basin. According to our estimates, areas of these glaciers did not significantly changed since 1989 however a certain regression of the glacier tongues had been fixed. The Kozlov glacier retreated with average rate of 21 m/year between 2001 and 2013. Retreat of the Potanin glacier was slower and between 1989 and 2001 the average rate was equal to 5 m/year, but between 2001 and 2013 it became more active and its average rate reached 24 m/year. One of the largest One of the largest rock

  20. Past changes, current state and future evolution of the ozone layer (United States)

    Godin-Beekmann, S.


    The ozone layer has been under scrutiny since the discovery of the ozone hole over Antarctica in the mid-eighties (Farman et al., 1985). The rapid disclosure of the main processes involved in polar ozone destruction lead to the signature of the Montreal Protocol that regulates the emission of ozone depleting substances (ODS). The objective of this presentation is to review the current understanding of past changes and current state of the ozone layer, the evolution of ODS concentration in the atmosphere and assess the projections of ozone recovery. Satellite measurements revealed a peak of ODS concentration in the mid and end of the nineties and ODS concentrations have started to decrease, albeit at a slower pace than during the increase period due to the atmospheric lifetimes of these compounds. The total ozone content has stabilized at global scale since the beginning of the 21st century. In 2009, integrated ozone content was about 3.5 % smaller in the 60°S-60°N region compared to values prior to 1980 (WMO, 2011). Climate change will influence the recovery of stratospheric. Both ozone depletion and increase of carbon dioxide induce a cooling of the stratosphere. In the winter polar stratosphere, this cooling enhances the formation of polar stratospheric clouds involved in the formation of the ozone hole. In the high stratosphere, it slows the chemical reactions destroying ozone and accelerates its reformation (WMO, 2011). Besides, most chemistry-climate models predict an acceleration of the stratospheric meridional circulation, which would speed up the ozone recovery (Eyring et al., 2010). This recovery is forecasted in periods ranging between 2015 and 2030 and between 2030 and 2040 in the northern and southern hemispheres, respectively. The Antarctic ozone hole will not disappear before 2050. Because of the acceleration of the meridional circulation, models simulate a super-recovery of ozone in the high latitude regions and an under recovery in the tropics. At

  1. Numerical methods in vehicle system dynamics: state of the art and current developments (United States)

    Arnold, M.; Burgermeister, B.; Führer, C.; Hippmann, G.; Rill, G.


    Robust and efficient numerical methods are an essential prerequisite for the computer-based dynamical analysis of engineering systems. In vehicle system dynamics, the methods and software tools from multibody system dynamics provide the integration platform for the analysis, simulation and optimisation of the complex dynamical behaviour of vehicles and vehicle components and their interaction with hydraulic components, electronical devices and control structures. Based on the principles of classical mechanics, the modelling of vehicles and their components results in nonlinear systems of ordinary differential equations (ODEs) or differential-algebraic equations (DAEs) of moderate dimension that describe the dynamical behaviour in the frequency range required and with a level of detail being characteristic of vehicle system dynamics. Most practical problems in this field may be transformed to generic problems of numerical mathematics like systems of nonlinear equations in the (quasi-)static analysis and explicit ODEs or DAEs with a typical semi-explicit structure in the dynamical analysis. This transformation to mathematical standard problems allows to use sophisticated, freely available numerical software that is based on well approved numerical methods like the Newton-Raphson iteration for nonlinear equations or Runge-Kutta and linear multistep methods for ODE/DAE time integration. Substantial speed-ups of these numerical standard methods may be achieved exploiting some specific structure of the mathematical models in vehicle system dynamics. In the present paper, we follow this framework and start with some modelling aspects being relevant from the numerical viewpoint. The focus of the paper is on numerical methods for static and dynamic problems, including software issues and a discussion which method fits best for which class of problems. Adaptive components in state-of-the-art numerical software like stepsize and order control in time integration are

  2. XBRL Standard for Financial Reporting in Croatia: Current State and Perspectives

    Directory of Open Access Journals (Sweden)

    Gostimir Dejan


    Full Text Available Background: Harmonization and standardization is becoming important among regulators and business community. XBRL has entered the global stage as a financial reporting standard. Its mission was to standardize the financial reporting, lower the reporting costs and make the reporting as transparent as possible.

  3. Nitric oxide in plants: an assessment of the current state of knowledge

    DEFF Research Database (Denmark)

    Mur, Luis A J; Mandon, Julien; Persijn, Stefan


    Background and aims After a series of seminal works during the last decade of the 20th century nitric oxide (NO) is now firmly placed in the pantheon of plant signals. NO acts in plant-microbe interactions, responses to abiotic stress, stomatal regulation and a range of developmental processes. B...

  4. Field-dependent critical state of high-Tc superconducting strip simultaneously exposed to transport current and perpendicular magnetic field (United States)

    Xue, Cun; He, An; Yong, Huadong; Zhou, Youhe


    We present an exact analytical approach for arbitrary field-dependent critical state of high-Tc superconducting strip with transport current. The sheet current and flux-density profiles are derived by solving the integral equations, which agree with experiments quite well. For small transport current, the approximate explicit expressions of sheet current, flux-density and penetration depth for the Kim model are derived based on the mean value theorem for integration. We also extend the results to the field-dependent critical state of superconducting strip in the simultaneous presence of applied field and transport current. The sheet current distributions calculated by the Kim model agree with experiments better than that by the Bean model. Moreover, the lines in the Ia-Ba plane for the Kim model are not monotonic, which is quite different from that the Bean model. The results reveal that the maximum transport current in thin superconducting strip will decrease with increasing applied field which vanishes for the Bean model. The results of this paper are useful to calculate ac susceptibility and ac loss.

  5. Field-dependent critical state of high-Tc superconducting strip simultaneously exposed to transport current and perpendicular magnetic field

    Directory of Open Access Journals (Sweden)

    Cun Xue


    Full Text Available We present an exact analytical approach for arbitrary field-dependent critical state of high-Tc superconducting strip with transport current. The sheet current and flux-density profiles are derived by solving the integral equations, which agree with experiments quite well. For small transport current, the approximate explicit expressions of sheet current, flux-density and penetration depth for the Kim model are derived based on the mean value theorem for integration. We also extend the results to the field-dependent critical state of superconducting strip in the simultaneous presence of applied field and transport current. The sheet current distributions calculated by the Kim model agree with experiments better than that by the Bean model. Moreover, the lines in the Ia-Ba plane for the Kim model are not monotonic, which is quite different from that the Bean model. The results reveal that the maximum transport current in thin superconducting strip will decrease with increasing applied field which vanishes for the Bean model. The results of this paper are useful to calculate ac susceptibility and ac loss.

  6. Field-dependent critical state of high-Tc superconducting strip simultaneously exposed to transport current and perpendicular magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Cun; He, An; Yong, Huadong; Zhou, Youhe, E-mail: [Key Laboratory of Mechanics on Disaster and Environment in Western China attached to the Ministry of Education of China, and Department of Mechanics and Engineering Sciences, College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu 730000 (China)


    We present an exact analytical approach for arbitrary field-dependent critical state of high-T{sub c} superconducting strip with transport current. The sheet current and flux-density profiles are derived by solving the integral equations, which agree with experiments quite well. For small transport current, the approximate explicit expressions of sheet current, flux-density and penetration depth for the Kim model are derived based on the mean value theorem for integration. We also extend the results to the field-dependent critical state of superconducting strip in the simultaneous presence of applied field and transport current. The sheet current distributions calculated by the Kim model agree with experiments better than that by the Bean model. Moreover, the lines in the I{sub a}-B{sub a} plane for the Kim model are not monotonic, which is quite different from that the Bean model. The results reveal that the maximum transport current in thin superconducting strip will decrease with increasing applied field which vanishes for the Bean model. The results of this paper are useful to calculate ac susceptibility and ac loss.

  7. Next-Generation Accountability Systems: An Overview of Current State Policies and Practices (United States)

    Rosenberg, Sarah


    With significant shifts in education, states are recognizing that students were not being taught at levels that adequately prepared them for college and careers and stepped up to develop and implement more rigorous standards. As part of this transition, states have also committed to better supports for educators to adapt to the new standards,…

  8. Vital Signs: The Current State of African Americans in Higher Education. (United States)

    Journal of Blacks in Higher Education, 2000


    Presents a statistical record of the progress of African Americans in higher education, offering: the Black-White Higher Education Equality Index; statistics that measure racial inequality; states in which black college enrollments are expected to grow over the next 15 years; and differences among the states in their percentages of low-income…

  9. Cognitive load theory and multimedia learning, task characteristics, and learning engagement: The current state of the art

    NARCIS (Netherlands)

    Kirschner, Femke; Kester, Liesbeth; Corbalan, Gemma


    Kirschner, F., Kester, L., & Corbalan, G. (2011). Cognitive load theory and multimedia learning, task characteristics, and learner engagement: The current state of the art. Computers in Human Behavior, 27, 1-4. doi:10.1016/j.chb.2010.05.003


    Directory of Open Access Journals (Sweden)

    S. Sernov


    Full Text Available The paper contains information on the current state of automotive lighting equipment. Different designs of automotive lighting devices, their merits and demerits are described in the paper. The paper includes a substantiation of expediency of developing light-emitting diode lighting and proposes recommendations about optimization of their design.

  11. Ideas on Learning a New Language Intertwined with the Current State of Natural Language Processing and Computational Linguistics (United States)

    Snyder, Robin M.


    In 2014, in conjunction with doing research in natural language processing and attending a global conference on computational linguistics, the author decided to learn a new foreign language, Greek, that uses a non-English character set. This paper/session will present/discuss an overview of the current state of natural language processing and…

  12. Current state in tracking and robotic navigation systems for application in endovascular aortic aneurysm repair

    NARCIS (Netherlands)

    De Ruiter, Quirina M B; Moll, Frans L.; Van Herwaarden, Joost A.


    Objective This study reviewed the current developments in manual tracking and robotic navigation technologies for application in endovascular aortic aneurysm repair (EVAR). Methods EMBASE and MEDLINE databases were searched for studies reporting manual tracking or robotic navigation systems that are

  13. Steady-state configurations of Dzyaloshinskii domain walls driven by field and current (United States)

    Sánchez-Tejerina, L.; Alejos, O.; Martínez, E.


    The dynamics of Dzyaloshinskii domain walls (DDW) in ultrathin ferromagnetic strips with perpendicular magnetic anisotropy, for different values of both perpendicular field and longitudinal current excitation associated to the Spin-Hall effect, has been studied, taking into account different values of the interfacial Dzyaloshinskii-Moriya interaction (DMI). This study has been carried out with the help of the q-Φ one-dimensional model and micromagnetic simulations. We have found that Walker breakdown may be avoided by applying a certain threshold current, even though the inverse effect is also possible. We have also found that, for particular values of field and current, the magnetization within the DDW experiences an abrupt change of orientation, which provokes a change on the contribution of current to the terminal DDW velocity. This effect disappears for sufficiently strong DMI, as it is expected from the model.

  14. Experimental pain processing in individuals with cognitive impairment: current state of the science

    DEFF Research Database (Denmark)

    Defrin, R; Amanzio, Martina; de Tomasso, M


    to cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited, but may be enhanced through the use of animal models of CI which also exhibit alterations in nociceptive responding. Further research employing additional behavioural...

  15. Research Initiatives for Materials State Sensing (RIMSS) Task Order 0020: High Frequency Eddy Current NDE (United States)


    coatings using eddy current techniques”, AIP Conference Proceedings , Vol. 1430, 2012, pp 441. 7. F. M. Smits, “Measurement of sheet resistivities with... Conference 2014: 27 October - 30 October, Charleston, SC, USA. “High-Frequency Eddy Current System for Analyzing Wet Conductive Coatings during...Processing”. 3. QNDE 2014 (ORAL PRESENTATION), 41st Annual Review of Progress in Quantitative Nondestructive Evaluation: Conference Boise Centre

  16. Current National Weather Service Watches, Warnings, or Advisories for the United States (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Weather Service (NWS) Storm Prediction Center uses RSS feeds to disseminate all watches, warnings and advisories for the United States that are...

  17. High or low-side solid state relay with current limiting and operational testing (United States)

    Dolland, C. R.


    The switch comprises a circuit from a first output terminal via parallel MOS devices in series with current-sensing resistance to a second output terminal, with alternative high-side and low-side configurations having a load between the second terminal and ground, or the first terminal and the DC supply voltage. An input terminal for a digital control signal is coupled via an input diode and two Schmitt Trigger CMOS inverters to a control lead for the gates of the switch. A current overload or short circuit protection circuit coupled between the current-sensor and the input diode comprises two transistors coupled by a diode. A built-in test circuit for indicating the switch condition (on, off, shorted or open) comprises MOS transistors having their gates connected to voltage dividers at the two output terminals, and their drains connected to discrete indication terminals.

  18. Resistive states created in superconducting NbTiN filaments by an electrical current pulse

    Directory of Open Access Journals (Sweden)

    K. Harrabi


    Full Text Available We have observed as a function of the time the appearance of the voltage caused by a larger-than-critical (I > Ic step-pulse of current in narrow NbTiN strips at 4.2 K. Different current intensities produced either phase-slip centres characterized by a voltage saturating with the time, or ever expanding hot spots. These dissipative structures occur after a measurable delay time, whose dependence upon the ratio I/Ic can be analysed through a Ginzburg-Landau theory to yield a unique adjustable time constant.

  19. The effects of current and expected future income on stated preferences for environmental improvements

    DEFF Research Database (Denmark)

    Jacobsen, Jette Bredahl; Lundhede, Thomas; Thorsen, Bo Jellesmark


    determinants for preferences. The effect of income on WTP seems to be caused by changes in preferences for environmental attributes rather than by marginal utility of income. The results suggest that to evaluate the distributional impacts of environmental improvements, researchers need a better measure......We formulate and test the hypothesis that expectations regarding changes in future income influences the WTP for environmental goods. For valuation of environmental goods in forests and other habitats in Denmark, we find that both current income and expected changes in future income are significant...... of expected future consumption options than current income....

  20. The Current Experiences of Physical Education Teachers at Schools for Blind Students in the United States (United States)

    Haegele, Justin A.; Lieberman, Lauren J.


    Introduction: It has been well established that children with visual impairments tend to be less physically active and more delayed in motor skills than their sighted peers. As a result, there has been some research focusing on inclusive physical education for these children. However, there is a clear lack of research on the current status of…

  1. Income in the United States: 2002. Current Population Reports. Consumer Income. (United States)

    DeNavas-Walt, Carmen; Cleveland, Robert W.; Webster, Bruce H., Jr.

    Using data from the 2003 Current Population Survey Annual Social and Economic Supplement, this study found that real median household money income declined by 1.1 percent between 2001-2002 to $42,409. Real median household income was unchanged between 2001-2002 for three of four alternative income definitions. The fourth, real median household…

  2. Current state and emission performance of CNG/LNG heavy-duty vehicles

    NARCIS (Netherlands)

    Ligterink, N.E.; Patuleia, A.F.; Koornneef, G.P.


    The use of natural gas and biogas for heavy-duty road transport is gaining popularity. Apart from economic benefits and supply security, the environmental advantages are often cited. This report, with an extended Dutch summary, gives an overview of the current situation in Europe, with a focus on Th

  3. Disturbingly Weak: The Current State of Financial Management Education in Library and Information Science Curricula (United States)

    Burger, Robert H.; Kaufman, Paula T.; Atkinson, Amy L.


    Financial management skills are necessary for responsible library management. In light of the profession's current emphasis on financial literacy, the authors posed four questions: (1) to what extent are library and information science schools providing courses in financial management for their graduates; (2) what is the quality and quantity of…


    Directory of Open Access Journals (Sweden)

    Naftanaila Ionel


    Full Text Available Under the current economic conditions many organizations strive to continue the trend towards adopting agile processes, in order to take advantage of the numerous benefits that these can offer. Those benefits include quicker return on investment, better s

  5. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis

    DEFF Research Database (Denmark)

    Caforio, Alida L P; Pankuweit, Sabine; Arbustini, Eloisa


    In this position statement of the ESC Working Group on Myocardial and Pericardial Diseases an expert consensus group reviews the current knowledge on clinical presentation, diagnosis and treatment of myocarditis, and proposes new diagnostic criteria for clinically suspected myocarditis and its...

  6. The extragalactic IR background

    CERN Document Server

    De Zotti, G; Mazzei, P; Toffolatti, L; Danese, L; De Zotti, G; Franceschini, A; Mazzei, P; Toffolatti, L; Danese, L


    Current limits on the intensity of the extragalactic infrared background are consistent with the expected contribution from evolving galaxies. Depending on the behaviour of the star formation rate and of the initial mass function, we can expect that dust extinction during early evolutionary phases ranges from moderate to strong. An example of the latter case may be the ultraluminous galaxy IRAS F10214 + 4724. The remarkable lack of high redshift galaxies in faint optically selected samples may be indirect evidence that strong extinction is common during early phases. Testable implications of different scenarios are discussed; ISO can play a key role in this context. Estimates of possible contributions of galaxies to the background under different assumptions are presented. The COBE/FIRAS limits on deviations from a blackbody spectrum at sub-mm wavelengths already set important constraints on the evolution of the far-IR emission of galaxies and on the density of obscured (``Type 2'') AGNs. A major progress in ...

  7. Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. (United States)

    Nikitin, E S; Kiss, T; Staras, K; O'shea, M; Benjamin, P R; Kemenes, G


    We have identified a TTX-resistant low-threshold persistent inward sodium current in the cerebral giant cells (CGCs) of Lymnaea, an important state-setting modulatory cell type of molluscan feeding networks. This current has slow voltage-dependent activation and de-activation kinetics, ultra-slow inactivation kinetics and fast de-inactivation kinetics. It activates at approximately -90 mV, peaks at approximately -30 mV, reverses at approximately +35 mV and does not show full voltage-dependent inactivation even at positive voltage steps. Lithium-sodium replacement experiments indicate that the persistent sodium current makes a significant contribution to the CGC membrane potential. Injection of cyclic adenosine monophosphate (cAMP) into the CGC cell body produces a large increase in the persistent sodium current that lasts for several hours. cAMP injection also leads to increased bursting, a significant decrease in the resistance and a significant depolarization of the soma membrane, indicating that cAMP-dependent mechanisms induce prolonged neuronal plasticity in the CGCs. Our observations provide the first link between cAMP-mediated modulation of a TTX-resistant persistent sodium current and prolonged neuronal plasticity in an identified modulatory cell type that plays an important role in behavioral state setting.

  8. The National Instructional Materials Accessibility Standard (NIMAS): Current State Implementation. inForum (United States)

    Muller, Eve; Burdette, Paula


    As part of the 2004 reauthorization of the Individuals with Disabilities Education Act (IDEA), states are required to comply with the National Instructional Materials Accessibility Standard (NIMAS) beginning July 19, 2006. NIMAS is defined as "the standard established by the Secretary to be used in the preparation of electronic files suitable…

  9. On the Question of the Current State of Autonomy of Higher Educational Institutions in Russia (United States)

    Gushchin, V. V.; Gureev, V. A.


    There is probably no one who doubts that education is a top-priority interest of the state. The future of the Russian Federation and its economic and legal stability depend on the level of development of the system of education. The right to an education is one of the most fundamental and essential constitutional rights of the citizens of the…

  10. Teacher Perspectives on the Current State of Computer Technology Integration into the Public School Classroom (United States)

    Zuniga, Ramiro


    Since the introduction of computers into the public school arena over forty years ago, educators have been convinced that the integration of computer technology into the public school classroom will transform education. Joining educators are state and federal governments. Public schools and others involved in the process of computer technology…

  11. Transient state of polarization in optical ground wire caused by lightning and impulse current (United States)

    Kurono, Masahiro; Isawa, K.; Kuribara, Masayuki


    This paper describes a transient state of polarization in an optical ground wire (OPGW) theoretically, experimentally and with field measurements in lightning conditions, which is considered one of the fastest phenomena of polarization fluctuations in the natural environment. These characteristics will be required for optical coherent communication for utilities in future and for application to sensing of lightning with OPGW.

  12. Regulation of zebrafish sleep and arousal states: current and prospective approaches

    Directory of Open Access Journals (Sweden)

    Cindy N Chiu


    Full Text Available Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal’s well-being and survival. Mammalian models have predominated sleep and arousal research, although in the past decade, invertebrate models have made significant contributions to our understanding of the genetic underpinnings of behavioral states. More recently, the zebrafish has emerged as a promising model system for sleep and arousal research. Here we review experimental evidence that the zebrafish, a diurnal vertebrate, exhibits fundamental behavioral and neurochemical characteristics of mammalian sleep and arousal. We also propose how specific advantages of the zebrafish can be harnessed to advance the field. These include tractable genetics to identify and manipulate molecular and cellular regulators of behavioral states, optical transparency to facilitate in vivo observation of neural structure and function, and amenability to high-throughput drug screens to discover novel therapies for neurological disorders.

  13. Design of Nonlinear Robust Rotor Current Controller for DFIG Based on Terminal Sliding Mode Control and Extended State Observer

    Directory of Open Access Journals (Sweden)

    Guowei Cai


    Full Text Available As to strong nonlinearity of doubly fed induction generators (DFIG and uncertainty of its model, a novel rotor current controller with nonlinearity and robustness is proposed to enhance fault ride-though (FRT capacities of grid-connected DFIG. Firstly, the model error, external disturbances, and the uncertain factors were estimated by constructing extended state observer (ESO so as to achieve linearization model, which is compensated dynamically from nonlinear model. And then rotor current controller of DFIG is designed by using terminal sliding mode variable structure control theory (TSMC. The controller has superior dynamic performance and strong robustness. The simulation results show that the proposed control approach is effective.

  14. Optimal state feedback control of brushless direct-current motor drive systems based on Lyapunov stability criterion

    Institute of Scientific and Technical Information of China (English)


    This paper develops a unified methodology for a real-time speed control of brushless direct-current motor drive systems in the presence of measurement noise and load torque disturbance. First, the mathematical model and hardware structure of system is established. Next, an optimal state feed back controller using the Kalman filter state estimation technique is derived.This is followed by an adaptive control algorithm to compensate for the effects of noise and disturbance. Those two algorithms working together can provide a very-high-speed regulation and dynamic response over a wide range of operating conditions.Simulated responses are presented to highlight the effectiveness of the proposed control strategy.

  15. Strategic Petroleum Reserve equation of state model development : current performance against measured data.

    Energy Technology Data Exchange (ETDEWEB)

    Lord, David L.; Rudeen, David Keith (GRAM, Inc., Albuquerque, NM)


    This report documents the progression of crude oil phase behavior modeling within the U.S. Strategic Petroleum Reserve vapor pressure program during the period 2004-2009. Improvements in quality control on phase behavior measurements in 2006 coupled with a growing body of degasification plant operations data have created a solid measurement baseline that has served to inform and significantly improve project understanding on phase behavior of SPR oils. Systematic tuning of the model based on proven practices from the technical literature have shown to reduce model bias and match observed data very well, though this model tuning effort is currently in process at SPR and based on preliminary data. The current report addresses many of the steps that have helped to build a strong baseline of data coupled with sufficient understanding of model features so that calibration is possible.

  16. The current state of affairs for disaster planning for a nuclear terrorist attack. (United States)

    Goffman, Thomas E


    The author presents current thinking on the effects of an atomic bomb blast from a medical point of view and will argue that current US Federal plans for a nuclear disaster are simply crude, insufficient, disarticulated, and principally relies on martial law as a means of crowd control. The simple physics of a fusion reaction bomb is discussed along with the plans of other countries, apparently "secret"American plans, which show a poor knowledge of the physics of nuclear bombs as well as poor insight into what will be needed to help the maximum number of citizens. An alternative plan involving computer modeling and educating the public to the effects of a fission explosion are presented. The key issue of statewide planning is discussed, as the Federal government has dumped medical problems on "the local level."

  17. Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play. (United States)

    Savitz, J B; Rauch, S L; Drevets, W C


    In response to queries about whether brain imaging technology has reached the point where it is useful for making a clinical diagnosis and for helping to guide treatment selection, the American Psychiatric Association (APA) has recently written a position paper on the Clinical Application of Brain Imaging in Psychiatry. The following perspective piece is based on our contribution to this APA position paper, which specifically emphasized the application of neuroimaging in mood disorders. We present an introductory overview of the challenges faced by researchers in developing valid and reliable biomarkers for psychiatric disorders, followed by a synopsis of the extant neuroimaging findings in mood disorders, and an evidence-based review of the current research on brain imaging biomarkers in adult mood disorders. Although there are a number of promising results, by the standards proposed below, we argue that there are currently no brain imaging biomarkers that are clinically useful for establishing diagnosis or predicting treatment outcome in mood disorders.

  18. [Service robots in elderly care. Possible application areas and current state of developments]. (United States)

    Graf, B; Heyer, T; Klein, B; Wallhoff, F


    The term "Service robotics" describes semi- or fully autonomous technical systems able to perform services useful to the well-being of humans. Service robots have the potential to support and disburden both persons in need of care as well as nursing care staff. In addition, they can be used in prevention and rehabilitation in order to reduce or avoid the need for help. Products currently available to support people in domestic environments are mainly cleaning or remote-controlled communication robots. Examples of current research activities are the (further) development of mobile robots as advanced communication assistants or the development of (semi) autonomous manipulation aids and multifunctional household assistants. Transport robots are commonly used in many hospitals. In nursing care facilities, the first evaluations have already been made. So-called emotional robots are now sold as products and can be used for therapeutic, occupational, or entertainment activities.

  19. Hydrogen Storage Materials for Mobile and Stationary Applications: Current State of the Art. (United States)

    Lai, Qiwen; Paskevicius, Mark; Sheppard, Drew A; Buckley, Craig E; Thornton, Aaron W; Hill, Matthew R; Gu, Qinfen; Mao, Jianfeng; Huang, Zhenguo; Liu, Hua Kun; Guo, Zaiping; Banerjee, Amitava; Chakraborty, Sudip; Ahuja, Rajeev; Aguey-Zinsou, Kondo-Francois


    One of the limitations to the widespread use of hydrogen as an energy carrier is its storage in a safe and compact form. Herein, recent developments in effective high-capacity hydrogen storage materials are reviewed, with a special emphasis on light compounds, including those based on organic porous structures, boron, nitrogen, and aluminum. These elements and their related compounds hold the promise of high, reversible, and practical hydrogen storage capacity for mobile applications, including vehicles and portable power equipment, but also for the large scale and distributed storage of energy for stationary applications. Current understanding of the fundamental principles that govern the interaction of hydrogen with these light compounds is summarized, as well as basic strategies to meet practical targets of hydrogen uptake and release. The limitation of these strategies and current understanding is also discussed and new directions proposed.

  20. Financing of current account deficit in new member states and Croatia

    Directory of Open Access Journals (Sweden)

    Radmila Jovančević


    Full Text Available The aim of this paper is to analyze the transition results in the countries of the last wave of accession to the European Union. After they joined the EU, the average productivity growth dropped in the fi rst year, but later this was overcome. While the rate of GDP growth rose in most NMS countries, current account deficits remained very high and foreign direct investments were not capable of covering current account defi cits in all NMS countries. Both the rising external debt in many NMS countries and the accumulation of household debts resulting from fast credit growth create a risk in most countries. The comparative analyses show that some governments need to work at sustainable economic policies to keep infl ation under control and reduce external vulnerability. The conclusion of the paper is that regardless of the availability of EU funds, national investment policy will have considerable impact on the real growth of the economy.

  1. Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development. (United States)

    Gennari, Luigi; Merlotti, Daniela; Valleggi, Fabrizio; Martini, Giuseppe; Nuti, Ranuccio


    Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen receptor agonists and antagonists. These drugs have been intensively studied over the past decade and have proven to be a highly versatile group for the treatment of different conditions associated with aging, including hormone-responsive cancer and osteoporosis. Tamoxifen and toremifene are currently used to treat advanced breast cancer and also have beneficial effects on bone mineral density and serum lipids in postmenopausal women. Raloxifene is the only SERM approved worldwide for the prevention and treatment of postmenopausal osteoporosis and vertebral fractures. However, although these SERMs have many benefits, they may also be responsible for some potentially very serious adverse effects, such as thromboembolic disorders and, in the case of tamoxifen, uterine cancer. These adverse effects represent a major concern given that long-term therapy is required to prevent osteoporosis. Moreover, both preclinical and clinical reports suggest that tamoxifen, toremifene and raloxifene are considerably less potent than estrogen. The search for the 'ideal' SERM, which would have estrogenic effects on bone and serum lipids, neutral effects on the uterus, and antiestrogenic effects on breast tissue, but none of the adverse effects associated with current therapies, is currently under way. Ospemifene, lasofoxifene, bazedoxifene and arzoxifene, which are new SERM molecules with potential greater efficacy and potency than previous SERMs, are currently under investigation for use in the treatment and prevention of osteoporosis. These drugs have been shown to be comparably effective to conventional hormone replacement therapy in animal models of osteoporosis, with potential indications for an improved safety profile. Clinical efficacy data from ongoing phase III trials are awaited so that a true understanding of

  2. Tiger Beetles' (Coleoptera: Carabidae, Cicindelinae) pupal stage: current state of knowledge and future perspectives. (United States)

    Roza, André S; Mermudes, José R M


    The tiger beetles (Carabidae: Cicindelinae) include about 2,822 species and 120 genera around the world. They are one of the most widely studied families of Coleoptera. However, the knowledge about their immature stages is incipient and usually restricted to the larval stages. Pupal characteristics have been among the most ignored aspects of tiger beetle biology. Here we compile and update the current knowledge of tiger beetle pupae.

  3. [The problems of education in otosurgery: the current state-of-the-art]. (United States)

    Ioannides, G F


    An overview of the current problems of education in ear surgery is presented. The methods used for the purpose including the classical dissection of the temporal bone, application of synthetic and natural (animal) temporal bones are described alongside with the 3D models of the temporal bone and virtual dissection. In addition, the review covers the problem of enhancing effectiveness of the teaching methods, considers their advantages and disadvantages.

  4. Dynamics at Solid State Surfaces and Interfaces, Volume 1 Current Developments

    CERN Document Server

    Bovensiepen, Uwe; Wolf, Martin


    This two-volume work covers ultrafast structural and electronic dynamics of elementary processes at solid surfaces and interfaces, presenting the current status of photoinduced processes. Providing valuable introductory information for newcomers to this booming field of research, it investigates concepts and experiments, femtosecond and attosecond time-resolved methods, as well as frequency domain techniques. The whole is rounded off by a look at future developments.

  5. Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives

    DEFF Research Database (Denmark)

    Gracia-Lor, Emma; Castiglioni, Sara; Bade, Richard


    lifestyle habits, health and wellbeing, but its selection is not an easy task as it should fulfil several specific requirements in order to be successfully employed. This paper aims to summarize the current knowledge related to the most relevant biomarkers used so far. In addition, some potential wastewater...... and pharmacokinetic data (i.e. metabolism and urinary excretion profile) has been reviewed. Finally, several needs and recommendations for future research are proposed....

  6. Invasive Carassius Carp in Georgia: Current state of knowledge and future perspectives

    Directory of Open Access Journals (Sweden)

    Bella JAPOSHVILI, Levan MUMLADZE, Fahrettin KÜÇÜK


    Full Text Available In Georgia, crucian carp Carassius carassius (Linnaeus, 1758 was known from only one locality after Kesslers record (1877–1878 with no new findings until 1985. Since then C. carassius rapidly and simultaneously invaded almost all water bodies of Georgia. In 2004, it was for the first time noted that this invasive Carassius sp. could not be a C. Carassius, but was a form of Carassius gibelio (Bloch, 1792. However no further data is available about this invasive species in Georgia. The aim of the present study was to investigate taxonomic status of Carassius sp. in Georgia using mtDNA phylogenetic analyses and morphometric study of truss network system. Genetic analysis revealed that invasive Carassius sp. is closely related to the C. gibelio from Turkey and other countries. In contrast, morphometrically Carassius sp. from Georgia can be easily differentiated from those of Turkey indicating high intraspecific variability. This is the first time discussion on the current knowledge of the present distribution of invasive carp in Georgia with identifying current problems and future research directions needed [Current Zoology 59 (6: 732–739, 2013].

  7. Family Background and Entrepreneurship

    DEFF Research Database (Denmark)

    Lindquist, Matthew J.; Sol, Joeri; Van Praag, Mirjam

    Vast amounts of money are currently being spent on policies aimed at promoting entrepreneurship. The success of such policies, however, rests in part on the assumption that individuals are not ‘born entrepreneurs’. In this paper, we assess the importance of family background and neighborhood...... treatment within families by gender and birth order does little to further increase our estimates of the importance of family-wide factors. We then go on to show that neighborhood effects, sibling peer effects, and parental income and education explain very little of these correlations. Parental...

  8. Resting-state functional magnetic resonance imaging in hepatic encephalopathy: current status and perspectives. (United States)

    Zhang, Long Jiang; Wu, Shengyong; Ren, Jiaqian; Lu, Guang Ming


    Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as attention, working memory, and so on. Blood oxygen level dependent (BOLD) functional MRI (fMRI), especially resting-state fMRI has been used to explore the brain functional changes of HE, yielding important insights for understanding pathophysiological mechanisms and functional reorganization of HE. This paper briefly reviews the principles of BOLD fMRI, potential applications of resting-state fMRI with advanced post-processing algorithms such as regional homogeneity, amplitude of low frequency fluctuation, functional connectivity and future research perspective in this field.

  9. [Epidemiologic knowledge and current situation of Chagas disease in the state of Jalisco, Mexico]. (United States)

    Lozano-Kasten, Felipe; Magallón-Gastélum, Ezequiel; Soto-Gutiérrez, Margarita; Kasten-Monges, Marina; Bosseno, Marie-France; Brenière, Simone Frédérique


    Chagas disease in the state of Jalisco, Mexico was described for the first time in 1967; however, knowledge on the disease remains in a slow process. Between 1967 and 2006, the disease was described in its acute and chronic forms. The vector species have been identified, and the parasite Trypanosoma cruzi has been isolated and genetically characterized. Also, the magnitude of the infection in humans has been determined through serological studies of different populations as well as of blood donors. The up-to-dateness of knowledge of the disease in the state of Jalisco, unveils a necessity of increased research on the epidemiology of Chagas disease as well as on clinical studies to assess the health of individuals and the populations.

  10. Neuroimaging training among neuropsychologists: A survey of the state of current training and recommendations for trainees



    Neuroimaging has gained widespread use in neuropsychological research and practice. However, there are neither established guidelines on how neuropsychologists might become competent researchers or consumers of neuroimaging data, nor any published studies describing the state of neuroimaging training among neuropsychologists. We report the results of two online surveys, one of 13 expert neuropsychologist-neuroimagers, whose responses informed the formulation of a second, larger survey to neur...

  11. Current trends in the global tourism industry: evidence from the United States

    Directory of Open Access Journals (Sweden)

    Nejdet Delener


    Full Text Available Tourism is one of the largest U.S. industries, serving millions of international and domestic tourists yearly. Tourists visit the U.S. to see natural wonders, cities, historic landmarks, and entertainment venues. Americans seek similar attractions as well as recreation and vacation areas. Tourism competes in the global market, so it is important to understand current trends in the U.S. travel industry. Therefore, this article offers insight into important trends and suggests strategies for policy makers involved in the travel and tourism industry.

  12. The current state of the creation and modernization of national geodetic and cartographic resources in Poland

    Directory of Open Access Journals (Sweden)

    Doskocz Adam


    Full Text Available All official data are currently integrated and harmonized in a spatial reference system. This paper outlines a national geodetic and cartographic resources in Poland. The national geodetic and cartographic resources are an important part of the spatial information infrastructure in the European Community. They also provide reference data for other resources of Spatial Data Infrastructure (SDI, including: main and detailed geodetic control networks, base maps, land and buildings registries, geodetic registries of utilities and topographic maps. This paper presents methods of producing digital map data and technical standards for field surveys, and in addition paper also presents some aspects of building Global and Regional SDI.

  13. The effects of current and expected future income on stated preferences for environmental improvements

    DEFF Research Database (Denmark)

    Jacobsen, Jette Bredahl; Lundhede, Thomas; Thorsen, Bo Jellesmark


    We formulate and test the hypothesis that expectations regarding changes in future income influences the WTP for environmental goods. For valuation of environmental goods in forests and other habitats in Denmark, we find that both current income and expected changes in future income are significant...... determinants for preferences. The effect of income on WTP seems to be caused by changes in preferences for environmental attributes rather than by marginal utility of income. The results suggest that to evaluate the distributional impacts of environmental improvements, researchers need a better measure...

  14. The antibacterial peptide ABP-CM4: the current state of its production and applications. (United States)

    Li, Jian Feng; Zhang, Jie; Xu, Xing Zhou; Han, Yang Yang; Cui, Xian Wei; Chen, Yu Qing; Zhang, Shuang Quan


    The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous efforts to develop new antibiotics with new modes of actions. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi, and tumor cells, which may possibly be used as a promising candidate for a new antibiotic. For pharmaceutical applications, a large quantity of antimicrobial peptides needs to be produced economically. In this communication, the progress in the structural characteristics, heterologous production, and biological evaluation of ABP-CM4 are reviewed.

  15. Treatment of Hip Dislocations and Associated Injuries: Current State of Care. (United States)

    Beebe, Michael J; Bauer, Jennifer M; Mir, Hassan R


    Hip dislocations, most often caused by motor vehicle accidents or similar high-energy trauma, traverse a large subset of distinct injury patterns. Understanding these patterns and their associated injuries allows surgeons to provide optimal care for these patients both in the early and late postinjury periods. Nonoperative care requires surgeons to understand the indications. Surgical care requires the surgeon to understand the benefits and limitations of several surgical approaches. This article presents the current understanding of hip dislocation treatment, focusing on anatomy, injury classifications, nonoperative and operative management, and postinjury care.

  16. [Current state of digestive system robotic surgery in the light of evidence based medicine]. (United States)

    Ortiz Oshiro, Elena; Fernández-Represa, Jesús Alvarez


    The incorporation of robotics in minimally invasive surgery has had mixed reception in the different fields of digestive surgery. Nowadays we are exposed to a continuous stream of publications on robotic approach techniques and outcomes, which do not always provide objective criteria and whose value, through scientific evidence analysis, is sometimes arguable. With the aim of shedding light on current knowledge on digestive robotic surgery and giving an update of its possibilities, the authors analyse the abundant literature available on the different digestive robotic surgery procedures, and sum up their own experience.

  17. Space charge and steady state current in LDPE samples containing a permittivity/conductivity gradient

    DEFF Research Database (Denmark)

    Holbøll, Joachim; Bambery, K. R.; Fleming, R. J.


    in a homogeneous sample is to establish a temperature gradient across it. The resulting spatial variation in ε is usually small in polymeric insulators, but the variation in σ can be appreciable. Laser induced pressure pulse (LIPP) measurements were made on 1.5 mm thick plaques of ultra pure LDPE equipped...... with vacuum-evaporated aluminium electrodes. Temperature differences up to 27°C were maintained across the samples, which were subjected to DC fields up to 20 kV/mm. Current density was measured as a function of temperature and field. Negligible thermally generated space charge was observed. The charge...

  18. What is the current state of the science of Cyber defense?

    Energy Technology Data Exchange (ETDEWEB)

    Hurd, Alan J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    My overall sense of the cyber defense field is one of an adolescent discipline currently bogged down in a cloud of issues, the most iconic of which is the great diversity of approaches that are being aggregated to form a coherent field. Because my own expertise is complex systems and materials physics research, I have limited direct experience in cyber security sciences except as a user of secure networks and computing resources. However, in producing this report, I have found with certainty that there exists no calculus for cyber risk assessment, mitigation, and response, although some hopeful precepts toward this end are emerging.

  19. Optimal Use of Current and Outdated Channel State Information - Degrees of Freedom of the MISO BC with Mixed CSIT

    CERN Document Server

    Gou, Tiangao


    We consider a multiple-input-single-output (MISO) broadcast channel with mixed channel state information at the transmitter (CSIT) that consists of imperfect current CSIT and perfect outdated CSIT. Recent work by Kobayashi et al. presented a scheme which exploits both imperfect current CSIT and perfect outdated CSIT and achieves higher degrees of freedom (DoF) than possible with only imperfect current CSIT or only outdated CSIT individually. In this work, we further improve the achievable DoF in this setting by incorporating additional private messages, and provide a tight information theoretic DoF outer bound, thereby identifying the DoF optimal use of mixed CSIT. The new result is stronger even in the original setting of only delayed CSIT, because it allows us to remove the restricting assumption of statistically equivalent fading for all users.

  20. Analysis of Short-circuit Characteristics and Calculation of Steady-state Short-circuit Current for DFIG Wind Turbine

    Institute of Scientific and Technical Information of China (English)


    Large-scale doubly-fed induction generator (DFIG) wind turbines are connected to the grid and required to remain grid-connection during faults, the short-circuit current contributed by the generation has become a significant issue. However, the traditional calculation methods aiming at synchronous generators cannot be directly applied to the DFIG wind turbines. A new method is needed to calculate the short-circuit current required by the planning, protection and control of the power grid. The short-circuit transition of DFIG under symmetrical and asymmetric short-circuit conditions are mathematically deduced, and the short-circuit characteristics of DFIG are analyzed. A new method is proposed to calculate the steady-state short-circuit current of DFIG based on the derived expressions. The time-domain simulations are conducted to verify the accuracy of the proposed method.

  1. Electron-deuteron scattering in a current-conserving description of relativistic bound states formalism and impulse approximation calculations

    CERN Document Server

    Phillips, D R; Devine, N K


    The electromagnetic interactions of a relativistic two-body bound state are formulated in three dimensions using an equal-time (ET) formalism. This involves a systematic reduction of four-dimensional dynamics to a three-dimensional form by integrating out the time components of relative momenta. A conserved electromagnetic current is developed for the ET formalism. It is shown that consistent truncations of the electromagnetic current and the $NN$ interaction kernel may be made, order-by-order in the coupling constants, such that appropriate Ward-Takahashi identities are satisfied. A meson-exchange model of the $NN$ interaction is used to calculate deuteron vertex functions. Calculations of electromagnetic form factors for elastic scattering of electrons by deuterium are performed using an impulse-approximation current. Negative-energy components of the deuteron's vertex function and retardation effects in the meson-exchange interaction are found to have only minor effects on the deuteron form factors.

  2. Metallic Fabrics as the Current Collector for High-Performance Graphene-Based Flexible Solid-State Supercapacitor. (United States)

    Yu, Jianhui; Wu, Jifeng; Wang, Haozong; Zhou, Anan; Huang, Chaoqiang; Bai, Hua; Li, Lei


    Flexible solid-state supercapacitors attract more and more attention as the power supply for wearable electronics. To fabricate such devices, the flexible and economical current collectors are needed. In this paper, we report the stainless steel fabrics as the current collector for high-performance graphene-based supercapacitors. The stainless steel fabrics have superior properties compared with the widely used flexible current collectors. The flexible supercapacitors show large specific capacitance of 180.4 mF/cm(2), and capacitance retention of 96.8% after 7500 charge-discharge cycles. Furthermore, 96.4% of the capacitance is retained after 800 repeating stretching-bending cycles. The high performance is related to the excellent conductivity, good mechanical flexibility, and high electrochemical stability of the stainless steel fabrics. The achievement of such high-performance and flexible supercapacitor can open up exciting opportunities for wearable electronics and energy storage applications.

  3. Characteristics of the spatiotemporal distribution of daily extreme temperature events in China: Minimum temperature records in different climate states against the background of the most probable temperature

    Institute of Scientific and Technical Information of China (English)

    Qian Zhong-Hua; Hu Jing-Guo; Feng Guo-Lin; Cao Yong-Zhong


    Based on the skewed function,the most probable temperature is defined and the spatiotemporal distributions of the frequencies and strengths of extreme temperature events in different climate states over China are investigated,where the climate states are referred to as State Ⅰ,State Ⅱ and State Ⅲ,i.e.,the daily minimum temperature records of 1961-1990,1971-2000,and 1981-2009.The results show that in space the frequency of high temperature events in summer decreases clearly in the lower and middle reaches of the Yellow River in State Ⅰ and that low temperature events decrease in northern China in State Ⅱ.In the present state,the frequency of high temperature events increases significantly in most areas over China except the north east,while the frequency of low temperature events decreases mainly in north China and the regions between the Yangtze River and the Yellow River.The distributions of frequencies and strengths of extreme temperature events are consistent in space.The analysis of time evolution of extreme events shows that the occurrence of high temperature events become higher with the change in state,while that of low temperature events decreases.High temperature events are becoming stronger as well and deserve to be paid special attention.

  4. Kinetics deformation of current-voltage characteristics of the varistor oxide structures due to overcharging of the localized states

    Directory of Open Access Journals (Sweden)

    Tonkoshkur A. S.


    Full Text Available Prolonged exposure of zinc oxide varistors to the electrical load leads to current-voltage characteristics (CVC deformation, which is associated with a change in the height and width of the intergranular barriers, which are main structural element of the varistors. Polarization phenomena in zinc oxide ceramics are studied in a number of works, but those are mainly limited to the study of the physics of the CVC deformation process and to determining the parameters of localized electronic states involved in this process. This paper presents the results on the simulation of the deformation of pulse CVC of a separate intergranular potential barrier at transient polarization/depolarization, associated with recharging of surface electronic states (SES, which cause this barrier. It is found that at high density of SES their degree of electron filling is small and the effect of DC voltage leads to a shift of pulse current-voltage characteristics into the region of small currents. Conversely, the low density SES are almost completely filled with electrons, and after crystallite polarization CVC is shifted to high currents. Experimental studies have confirmed the possibility of applying the discovered laws to ceramic varistor structures. The proposed model allows interpreting the «anomalous» effects (such as increase in the classification voltage and reduction of active losses power observed during the varistors accelerated aging test.

  5. Crash Models for Advanced Automotive Batteries: A Review of the Current State of the Art

    Energy Technology Data Exchange (ETDEWEB)

    Turner, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Allu, Srikanth [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gorti, Sarma B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kalnaus, Sergiy [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kumar, Abhishek [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lebrun-Grandie, Damien T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pannala, Sreekanth [Saudi Arabia Basic Industries Corporation (SABIC), Houston, TX (United States); Simunovic, Srdjan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Slattery, Stuart R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Hsin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)


    Safety is a critical aspect of lithium-ion (Li-ion) battery design. Impact/crash conditions can trigger a complex interplay of mechanical contact, heat generation and electrical discharge, which can result in adverse thermal events. The cause of these thermal events has been linked to internal contact between the opposite electrodes, i.e. internal short circuit. The severity of the outcome is influenced by the configuration of the internal short circuit and the battery state. Different loading conditions and battery states may lead to micro (soft) shorts where material burnout due to generated heat eliminates contact between the electrodes, or persistent (hard) shorts which can lead to more significant thermal events and potentially damage the entire battery system and beyond. Experimental characterization of individual battery components for the onset of internal shorts is limited, since it is impractical to canvas all possible variations in battery state of charge, operating conditions, and impact loading in a timely manner. This report provides a survey of modeling and simulation approaches and documents a project initiated and funded by DOT/NHTSA to improve modeling and simulation capabilities in order to design tests that provide leading indicators of failure in batteries. In this project, ORNL has demonstrated a computational infrastructure to conduct impact simulations of Li-ion batteries using models that resolve internal structures and electro-thermo-chemical and mechanical conditions. Initial comparisons to abuse experiments on cells and cell strings conducted at ORNL and Naval Surface Warfare Center (NSWC) at Carderock MD for parameter estimation and model validation have been performed. This research has provided insight into the mechanisms of deformation in batteries (both at cell and electrode level) and their relationship to the safety of batteries.

  6. Vitamin E and the Healing of Bone Fracture: The Current State of Evidence

    Directory of Open Access Journals (Sweden)

    Boekhtiar Borhanuddin


    Full Text Available Background. The effect of vitamin E on health-related conditions has been extensively researched, with varied results. However, to date, there was no published review of the effect of vitamin E on bone fracture healing. Purpose. This paper systematically audited past studies of the effect of vitamin E on bone fracture healing. Methods. Related articles were identified from Medline, CINAHL, and Scopus databases. Screenings were performed based on the criteria that the study must be an original study that investigated the independent effect of vitamin E on bone fracture healing. Data were extracted using standardised forms, followed by evaluation of quality of reporting using ARRIVE Guidelines, plus recalculation procedure for the effect size and statistical power of the results. Results. Six animal studies fulfilled the selection criteria. The study methods were heterogeneous with mediocre reporting quality and focused on the antioxidant-related mechanism of vitamin E. The metasynthesis showed α-tocopherol may have a significant effect on bone formation during the normal bone remodeling phase of secondary bone healing. Conclusion. In general, the effect of vitamin E on bone fracture healing remained inconclusive due to the small number of heterogeneous and mediocre studies included in this paper.

  7. The evolution, current status, and regulation of ostomy products in the United States. (United States)

    Turnbull, G B


    In today's rapidly evolving health care environment in which quality, cost-effectiveness, and outcomes are among the most valued health care products, significant issues must be addressed regarding ostomy products and how persons with stomas use them. The lack of evidence-based data has a direct impact on the pocketbooks of many patients with ostomies in the United States and their quality of life. Regulators, accrediting agencies, and payers look to WOC nurses and other providers to provide a sound scientific base upon which they can develop standards and regulations that will improve the life of Americans with stomas.

  8. Macroscopic states induced in superconducting media by a transport current under flux creep (United States)

    Romanovskii, V. R.


    The physical features of the formation of macroscopic states of superconducting composites consisting of a superconductor and a coating under flux creep are discussed. It is demonstrated that there exist characteristic electric field strengths depending on the properties of the superconductor, cooling conditions, and characteristics of the stabilizing coating, which affect the intensity of the E-I characteristics of the superconducting composites. Analysis shows that the measurements of the critical properties of superconductors can be accompanied by a nonuniform electric field distribution over the composite cross section and high stable superheating of the superconductor, which do not lead to superconductivity breaking.

  9. Moscow State University near-Earth radiation monitoring satellite system: current status and development (United States)

    Panasyuk, Mikhail


    Radiation measurements using instruments have been designed and manufacturing in the Skobeltsyn Institute of Nuclear Physics of Lomonosov Moscow State University and installed onboard different satellites,i.e. LEO -"Meteor", ISS, GPS - GLONASS, GEO - "Electro" are presented as a basis of radiation monitoring system for control of radiation condition with a goal for to decrease radiation risk of spacecraft's damage on different orbits. Development of this system including radiation measurements onboard "Lomonosov"(LEO) satellite will be presented as well together with future project of multispacecraft LEO system for radiation monitoring.

  10. A Study on Maneuvering Obstacle Motion State Estimation for Intelligent Vehicle Using Adaptive Kalman Filter Based on Current Statistical Model

    Directory of Open Access Journals (Sweden)

    Bao Han


    Full Text Available The obstacle motion state estimation is an essential task in intelligent vehicle. The ASCL group has developed such a system that uses a radar and GPS/INS. When running on the road, the acceleration of the vehicle is always changing, so it is hard for constant velocity (CV model and constant acceleration (CA model to describe the motion state of the vehicle. This paper introduced Current Statistical (CS model from military field, which uses the modified Rayleigh distribution to describe acceleration. The adaptive Kalman filter based on CS model was used to estimate the motion state of the target. We conducted simulation experiments and real vehicle tests, and the results showed that the estimation of position, velocity, and acceleration can be precise.

  11. A review of the current geographic distribution of and debate surrounding electronic cigarette clean air regulations in the United States. (United States)

    Kadowaki, Joy; Vuolo, Mike; Kelly, Brian C


    In this article, we present the results of a systematic review of state, county, and municipal restrictions on the use of electronic cigarettes (e-cigarettes) in public spaces within the United States, alongside an overview of the current legal landscape. The lack of federal guidance leaves lower-level jurisdictions to debate the merits of restrictions on use in public spaces without sufficient scientific research. As we show through a geographic assessment of restrictions, this has resulted in an inconsistent patchwork of e-cigarette use bans across the United States of varying degrees of coverage. Bans have emerged over time in a manner that suggests a "bottom up" diffusion of e-cigarette clean air policies. Ultimately, the lack of clinical and scientific knowledge on the risks and potential harm reduction benefits has led to precautionary policymaking, which often lacks grounding in empirical evidence and results in spatially uneven diffusion of policy.

  12. Low-level radioactive waste disposal in the United States: An overview of current commercial regulations and concepts

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, W.E. Jr.


    Commercial low-level radioactive waste disposal in the United States is regulated by the US Nuclear Regulatory Commission (NRC) under 10 CFR 61 (1991). This regulation was issued in 1981 after a lengthy and thorough development process that considered the radionuclide concentrations and characteristics associated with commercial low-level radioactive waste streams; alternatives for waste classification; alternative technologies for low-level radioactive waste disposal; and data, modeling, and scenario analyses. The development process also included the publication of both draft and final environmental impact statements. The final regulation describes the general provisions; licenses; performance objectives; technical requirements for land disposal; financial assurances; participation by state governments and Indian tribes; and records, reports, tests, and inspections. This paper provides an overview of, and tutorial on, current commercial low-level radioactive waste disposal regulations in the United States.

  13. Noise and current correlations in tunnel junctions of quantum spin Hall edge states (United States)

    Dolcini, Fabrizio


    The edge channels of two-dimensional topological systems are protected from elastic reflection and are noiseless at low temperature. Yet, noise and cross correlations can be induced when electron waves partly transmit to the opposite edge via tunneling through a constriction. In particular, in a quantum spin Hall (QSH) system tunneling occurs via both spin-preserving (p ) and spin-flipping (f ) processes, each fulfilling time-reversal symmetry. We investigate the current correlations of a four-terminal QSH setup in the presence of a tunneling region, both at equilibrium and out of equilibrium. We find that, although p and f processes do not commute and the generic current correlation depends on both, under appropriate conditions a direct detection of two types of partition noise is possible. In particular, while the spin-preserving partitioning can be probed for any arbitrary tunnel junction with a specific configuration of terminal biases, the spin-flipping partitioning can be directly detected only under suitably designed setups and conditions. We describe two setups where these conditions can be fulfilled, and both types of partitioning can be detected and controlled.

  14. Partitioning and transmutation (P and D) 1995. A review of the current state of the art

    Energy Technology Data Exchange (ETDEWEB)

    Skaalberg, M.; Landgren, A.; Spjuth, L.; Liljenzin, J.O. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Nuclear Chemistry; Gudowski, W. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Neutron and Reactor Physics


    The recent development in the field of partitioning and transmutation (P/T) is reviewed and evaluated. Current national and international R and D efforts are summarized. Nuclear transmutation with energy production is feasible in nuclear reactors where fast and thermal breeders are the most efficient for transmutation purposes. The operation of subcritical nuclear reactors by high current proton accelerators that generate neutrons in a spallation target is also an interesting option for transmutation and energy production, that has to be more carefully evaluated. These accelerator-driven systems are probably the only solution for the transmutation of long-lived fission products with small neutron capture cross sections and actinide isotopes with small fission cross sections. The requirements on the separation chemistry in the partitioning process depends on the transmutation strategy chosen. Recent developments in aqueous based separation chemistry opens some interesting possibilities to meet some of the requirements, such as separation of different actinides and some fission products and reduction of secondary waste streams. In the advanced accelerator-driven transmutation systems proposed, liquid fuels such as molten salts are considered. The partitioning processes that can be used for these types of fuel will, however, require a long term research program. The possibility to use centrifuge separation is an interesting partitioning option that recently has been proposed. 51 refs, 7 figs, 3 tabs.

  15. Current state of sludge production, management, treatment and disposal in China. (United States)

    Yang, Guang; Zhang, Guangming; Wang, Hongchen


    Large amount of sludge has been a great trouble and raised significant concerns in China. This paper reviewed the current situation of sludge production, management, treatment and disposal in China. Total sludge production in China had an average annual growth of 13% from 2007 to 2013, and 6.25 million tons dry solids was produced in 2013. Per Capita sludge production in China is lower than that in developed countries. However, sludge management is poor in China. Administrative agents of sludge are not in accordance with each other. Laws and regulations of sludge management are incomplete and sometimes unrealistic. As to sludge treatment and disposal, many technical routes have been applied in China. Thickening, conditioning, and dewatering are three most used treatment methods, while application ratios of stabilization and drying are low in China. More than 80% of sludge is disposed by improper dumping in China. Regarding proper disposal, sanitary landfill is the commonest, followed by land application, incineration and building materials. According to the overall situation of China, "thickening-anaerobic digestion-dewatering-land application" is the priority technical route of sludge treatment and disposal. Good changes, current challenges and future perspectives of this technical route in China were analyzed and discussed in details.

  16. Current state-of-the-art and future perspectives of robotic technology in neurosurgery. (United States)

    Mattei, Tobias A; Rodriguez, Abraham Hafiz; Sambhara, Deepak; Mendel, Ehud


    Neurosurgery is one of the most demanding surgical specialties in terms of precision requirements and surgical field limitations. Recent advancements in robotic technology have generated the possibility of incorporating advanced technological tools to the neurosurgical operating room. Although previous studies have addressed the specific details of new robotic systems, there is very little literature on the strengths and drawbacks of past attempts, currently available platforms and prototypes in development. In this review, the authors present a critical historical analysis of the development of robotic technology in neurosurgery as well as a comprehensive summary of the currently available systems that can be expected to be incorporated to the neurosurgical armamentarium in the near future. Finally, the authors present a critical analysis of the main technical challenges in robotic technology development at the present time (such as the design of improved systems for haptic feedback and the necessity of incorporating intraoperative imaging data) as well as the benefits which robotic technology is expected to bring to specific neurosurgical subspecialties in the near future.

  17. Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. (United States)

    Radenković, Miroslav; Stojanović, Marko; Prostran, Milica


    Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal models of diabetes represent an important tool in diabetes investigation that helps us to avoid unnecessary and ethically challenging studies in human subjects, as well as to obtain a comprehensive scientific viewpoint of this disease. Although there are several methods through which diabetes can be induced, chemical methods of alloxan- and streptozotocin-induced diabetes represent the most important and highly preferable experimental models for this pathological condition. Therefore, the aim of this article was to review the current knowledge related to quoted models of diabetes, including to this point available information about mechanism of action, particular time- and dose-dependent protocols, frequent problems, as well as major limitations linked to laboratory application of alloxan and sterptozotocin in inducing diabetes. Given that diabetes is known to be closely associated with serious health consequences it is of fundamental importance that current animal models for induction of diabetes should be continuously upgraded in order to improve overall prevention, diagnosis and treatment of this pathological condition.

  18. Review of the current state of whole slide imaging in pathology

    Directory of Open Access Journals (Sweden)

    Liron Pantanowitz


    Full Text Available Whole slide imaging (WSI, or "virtual" microscopy, involves the scanning (digitization of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI for rendering pathologic diagnoses on a routine basis has been shown to be successful in only a few "niche" applications. Wider adoption will most likely require full integration with the laboratory information system, continuous automated scanning, high-bandwidth connectivity, massive storage capacity, and more intuitive user interfaces. Nevertheless, WSI has been reported to enhance specific pathology practices, such as scanning slides received in consultation or of legal cases, of slides to be used for patient care conferences, for quality assurance purposes, to retain records of slides to be sent out or destroyed by ancillary testing, and for performing digital image analysis. In addition to technical issues, regulatory and validation requirements related to WSI have yet to be adequately addressed. Although limited validation studies have been published using WSI there are currently no standard guidelines for validating WSI for diagnostic use in the clinical laboratory. This review addresses the current status of WSI in pathology related to regulation and validation, the provision of remote and routine pathologic diagnoses, educational uses, implementation issues, and the cost-benefit analysis of adopting WSI in routine clinical practice.

  19. Review of the current state of whole slide imaging in pathology. (United States)

    Pantanowitz, Liron; Valenstein, Paul N; Evans, Andrew J; Kaplan, Keith J; Pfeifer, John D; Wilbur, David C; Collins, Laura C; Colgan, Terence J


    Whole slide imaging (WSI), or "virtual" microscopy, involves the scanning (digitization) of glass slides to produce "digital slides". WSI has been advocated for diagnostic, educational and research purposes. When used for remote frozen section diagnosis, WSI requires a thorough implementation period coupled with trained support personnel. Adoption of WSI for rendering pathologic diagnoses on a routine basis has been shown to be successful in only a few "niche" applications. Wider adoption will most likely require full integration with the laboratory information system, continuous automated scanning, high-bandwidth connectivity, massive storage capacity, and more intuitive user interfaces. Nevertheless, WSI has been reported to enhance specific pathology practices, such as scanning slides received in consultation or of legal cases, of slides to be used for patient care conferences, for quality assurance purposes, to retain records of slides to be sent out or destroyed by ancillary testing, and for performing digital image analysis. In addition to technical issues, regulatory and validation requirements related to WSI have yet to be adequately addressed. Although limited validation studies have been published using WSI there are currently no standard guidelines for validating WSI for diagnostic use in the clinical laboratory. This review addresses the current status of WSI in pathology related to regulation and validation, the provision of remote and routine pathologic diagnoses, educational uses, implementation issues, and the cost-benefit analysis of adopting WSI in routine clinical practice.

  20. Modeling the Current and Future Roles of Particulate Organic Nitrates in the Southeastern United States. (United States)

    Pye, Havala O T; Luecken, Deborah J; Xu, Lu; Boyd, Christopher M; Ng, Nga L; Baker, Kirk R; Ayres, Benjamin R; Bash, Jesse O; Baumann, Karsten; Carter, William P L; Edgerton, Eric; Fry, Juliane L; Hutzell, William T; Schwede, Donna B; Shepson, Paul B


    Organic nitrates are an important aerosol constituent in locations where biogenic hydrocarbon emissions mix with anthropogenic NOx sources. While regional and global chemical transport models may include a representation of organic aerosol from monoterpene reactions with nitrate radicals (the primary source of particle-phase organic nitrates in the Southeast United States), secondary organic aerosol (SOA) models can underestimate yields. Furthermore, SOA parametrizations do not explicitly take into account organic nitrate compounds produced in the gas phase. In this work, we developed a coupled gas and aerosol system to describe the formation and subsequent aerosol-phase partitioning of organic nitrates from isoprene and monoterpenes with a focus on the Southeast United States. The concentrations of organic aerosol and gas-phase organic nitrates were improved when particulate organic nitrates were assumed to undergo rapid (τ = 3 h) pseudohydrolysis resulting in nitric acid and nonvolatile secondary organic aerosol. In addition, up to 60% of less oxidized-oxygenated organic aerosol (LO-OOA) could be accounted for via organic nitrate mediated chemistry during the Southern Oxidants and Aerosol Study (SOAS). A 25% reduction in nitrogen oxide (NO + NO2) emissions was predicted to cause a 9% reduction in organic aerosol for June 2013 SOAS conditions at Centreville, Alabama.

  1. Current trends in the prevalence of Cryptococcus gattii in the United States and Canada

    Directory of Open Access Journals (Sweden)

    Espinel-Ingroff A


    Full Text Available Ana Espinel-Ingroff,1 Sarah E Kidd21VCU Medical Center, Richmond, VA, USA; 2National Mycology Reference Center, SA Pathology, Adelaide, SA, AustraliaAbstract: The incidence of Cryptococcus gattii infections in both Canada and the United States (US is provided in this literature review beyond the British Columbia (BC outbreak (1999–2013. Based on a search of the literature, case reports of C. gattii human infections including the prevalent molecular genotypes causing these infections in both Canada and the US have been documented since the C. gattii outbreak in BC. The literature reveals that: i although C. gattii infections continue to be reported in both countries, the preliminary overall number of confirmed C. gattii infections may be decreasing in both Canada and the US (~23 cases each in 2012 versus ~17 and 20 cases, respectively in 2013; ii C. gattii genotype distribution is region-dependent; iii C. gattii is more frequently isolated from infections in the immunocompromised host (including acquired immune deficiency syndrome [AIDS] infection than previously expected; iv although pulmonary disease is higher than in C. neoformans infections, central nervous system disease is also reported among patients infected with C. gattii.Keywords: C. gattii, human infections, incidence, molecular epidemiology, United States, Canada 

  2. [Mosquito fauna (Diptera:Culicidae) from Falcon State, Venezuela. I. New records and current checklist]. (United States)

    Navarro, J C; Bastidas, R J; Zavala, Y


    A total of 16 new species records of Culicidae from Falcon State was collected at the "Juan Crisostomo Falcon National Park" (Sierra de San Luis), Natural Monument "Cerro Santa Ana", Coro, and La Vela. Species of Sabethini, Culicini and Toxorhynchitini Tribes were found in natural breeding sites (Phytotelmata), with special occurrence in plants belonging to Tillandsia, Vriesea, Guzmania, Aechmea (Bromelianceae), Heliconia (Heliconiaceae), Calathea (Marantaceae) and Colocasia (Araceae). Aedini and Mansonini were collected only as adults. A specie of Culex (Carrollia) was collected from an artificial container. The Culicidae species belong to 6 genera out of the 23 genera reported from Venezuela (Culex, Wyeomyia, Johnbelkinia, Aedes, Psorophora, Mansonia and Coquillettidia) and to 5 Tribes out of the 9 present in the country. The Aedini, Sabethini and Culicini Tribes were richer in species with 5, 4 and 4 species, respectively, than the Mansonini (2 species) and Toxorhynchitini (1 species) Tribes. We discuss some bioecological aspects regarding the 16 new-species records in Falcon State and give a checklist of the mosquito species previously reported in the literature.

  3. Collagenase Treatment in Dupuytren Contractures: A Review of the Current State Versus Future Needs. (United States)

    Degreef, Ilse


    use are weighed, founded by the available scientific background. The demands and options for collagenase in future treatment regimens for extensile Dupuytren contractures are discussed.

  4. Industrial-Strength Model-Based Testing - State of the Art and Current Challenges

    Directory of Open Access Journals (Sweden)

    Jan Peleska


    Full Text Available As of today, model-based testing (MBT is considered as leading-edge technology in industry. We sketch the different MBT variants that - according to our experience - are currently applied in practice, with special emphasis on the avionic, railway and automotive domains. The key factors for successful industrial-scale application of MBT are described, both from a scientific and a managerial point of view. With respect to the former view, we describe the techniques for automated test case, test data and test procedure generation for concurrent reactive real-time systems which are considered as the most important enablers for MBT in practice. With respect to the latter view, our experience with introducing MBT approaches in testing teams are sketched. Finally, the most challenging open scientific problems whose solutions are bound to improve the acceptance and effectiveness of MBT in industry are discussed.

  5. [Methodology for the development and update of practice guidelines: current state]. (United States)

    Barrera-Cruz, Antonio; Viniegra-Osorio, Arturo; Valenzuela-Flores, Adriana Abigail; Torres-Arreola, Laura Pilar; Dávila-Torres, Javier


    The current scenario of health services in Mexico reveals as a priority the implementation of strategies that allow us to better respond to the needs and expectations of individuals and society as a whole, through the provision of efficient and effective alternatives for the prevention, diagnosis and treatment of diseases. In this context, clinical practice guidelines constitute an element of management in the health care system, whose objective is to establish a national bechmark for encouraging clinical and management decision making, based on recommendations from the best available evidence, in order to contribute to the quality and effectiveness of health care. The purpose of this document is to show the methodology used for the development and updating of clinical practice guidelines that the Instituto Mexicano del Seguro Social has developed in line with the sectorial model in order to serve the user of these guidelines.

  6. An analysis of risk markers in husband to wife violence: the current state of knowledge. (United States)

    Hotaling, G T; Sugarman, D B


    The present review involves the evaluation of 97 potential risk markers of husband to wife violence. Using 52 case-comparison studies as the source of data, markers were divided into four categories: consistent risk, inconsistent risk, consistent nonrisk, and risk markers with insufficient data. Based on this classification, it appears that a number of widely held hypotheses about husband to wife violence have little empirical support. Only witnessing violence in the wife's family of origin was consistently associated with being victimized by violence. Furthermore, it seems that characteristics associated with either the husband-offender or the couple have greater utility for assessing the risk of husband to wife violence than characteristics of the wife-victim. Findings are discussed in terms of the methodological and theoretical implications of current research on this form of adult domestic violence.

  7. Current status of advanced gastrointestinal endoscopy training fellowships in the United States

    Directory of Open Access Journals (Sweden)

    Stephen J Heller


    Full Text Available Stephen J Heller, Jeffrey L TokarDepartment of Medicine, Fox Chase Cancer Center, Philadelphia, PA, USAAbstract: Rapid growth in the field of advanced gastrointestinal endoscopy has led to an increase in specialized therapeutic endoscopy fellowships. The cornerstones of these programs are training in endoscopic retrograde cholangiopancreatography (ERCP and endoscopic ultrasound. These procedures are more complex and challenging to master than routine colonoscopy and upper endoscopy, and in the case of ERCP, higher risk. The concentration of the educational experience in the hands of relatively fewer trainees with specialized interest in advanced endoscopy has resulted in providing a focused cohort of graduating fellows with higher case volumes in training, which likely enhances diagnostic and therapeutic success and safer performance of these procedures. Endoscopic simulators, although not currently in widespread use, have the potential to improve advanced procedural training without jeopardizing patient safety.Keywords: gastrointestinal endoscopy, training, procedures, safety 

  8. Current state and future prospects of direct-to-consumer (DTC pharmacogenetics

    Directory of Open Access Journals (Sweden)

    Eng Wee eChua


    Full Text Available Direct-to-consumer (DTC DNA testing has grown from contentious beginnings into a global industry, by providing a wide range of personal genomic information directly to its clients. These companies, typified by the well-established 23andMe, generally carry out a gene-chip analysis of single nucleotide polymorphisms (SNPs using DNA extracted from a saliva sample. These genetic data are then assimilated and provided direct to the client, with varying degrees of interpretation. Although much debate has focused on the limitations and ethical aspects of providing genotypes for disease risk alleles, the provision of pharmacogenetic results by DTC companies is less studied. We set out to evaluate current DTC pharmacogenetics offerings, and then to consider how these services might best evolve and adapt in order to play a potentially useful future role in delivery of personalized medicine.

  9. Ecological validity of pediatric neuropsychological measures: current state and future directions. (United States)

    Olson, Katie; Jacobson, Kristin K; Van Oot, Peter


    Neuropsychologists are increasingly requested to identify specific deficits in cognitive abilities and determine the ways in which these deficits will affect a client's everyday functioning. The demand for prescriptive diagnostic endeavors that provide recommendations for rehabilitation has drawn attention to the necessity of considering the ecological validity of instruments. Most of the current knowledge regarding the ecological validity of neuropsychological measures is the result of studies examining adult and older adult populations. The relationship of test performance and everyday functioning in children has been less examined and is, therefore, less understood. The purpose of this article is to provide a brief history of ecological validity in neuropsychology, discuss why this is an important consideration when working with child populations, and provide suggestions for continued research in this field.

  10. Statistical measures of genetic differentiation of populations:Rationales, history and current states

    Institute of Scientific and Technical Information of China (English)

    Liang MA; Ya-Jie JI; De-Xing ZHANG


    Population differentiation is a fundamental process of evolution, and many evolutionary studies, such as population genetics, phylogeography and conservation biology, all require the inference of population differentiation. Recently, there has been a lot of debate over the validity ofFST (and its analogueGST) as a measure for population genetic differentiation, notably since the proposal of the new indexD in 2008. Although several papers reviewed or explored specific features of these statistical measures, a succinct account of this bewildering issue with an overall update appears to be desirable. This is the purpose of the present review. The available statistics generally fall into two categories, represented byFST andD, respectively. None of them is perfect in measuring population genetic differentiation. Nevertheless, they each have advantages and are valuable for current re-search. In practice, both indices should be calculated and a comparison of them can generate useful insights into the evolutionary processes that influence population differentiation.FST (GST) has some unique irreplaceable characteristics assuring its standing as the default measure for the foreseeable near future. Also, it will continue to serve as the standard for any alternative measures to contrast with. Instead of being anxious about making choice between these indices, one should pay due attention to the equili-brium status and the level of diversity (especiallyHS) of the populations, since they largely sway the power of a given statistic to address a specific question. We provide a multi-faceted comparative summary of the various statistics, which can serve as a basic reference for readers to guide their applications [Current Zoology 61 (5): 886–897, 2015].

  11. In vivo confocal microscopy for the oral cavity: Current state of the field and future potential. (United States)

    Maher, N G; Collgros, H; Uribe, P; Ch'ng, S; Rajadhyaksha, M; Guitera, P


    Confocal microscopy (CM) has been shown to correlate with oral mucosal histopathology in vivo. The purposes of this review are to summarize what we know so far about in vivo CM applications for oral mucosal pathologies, to highlight some current developments with CM devices relevant for oral applications, and to formulate where in vivo CM could hold further application for oral mucosal diagnosis and management. Ovid Medline® and/or Google® searches were performed using the terms 'microscopy, confocal', 'mouth neoplasms', 'mouth mucosa', 'leukoplakia, oral', 'oral lichen planus', 'gingiva', 'cheilitis', 'taste', 'inflammatory oral confocal', 'mucosal confocal' and 'confocal squamous cell oral'. In summary, inclusion criteria were in vivo use of any type of CM for the human oral mucosa and studies on normal or pathological oral mucosa. Experimental studies attempting to identify proteins of interest and microorganisms were excluded. In total 25 relevant articles were found, covering 8 main topics, including normal oral mucosal features (n=15), oral dysplasia or neoplasia (n=7), inflamed oral mucosa (n=3), taste impairment (n=3), oral autoimmune conditions (n=2), pigmented oral pathology/melanoma (n=1), delayed type hypersensitivity (n=1), and cheilitis glandularis (n=1). The evidence for using in vivo CM in these conditions is poor, as it is limited to mainly small descriptive studies. Current device developments for oral CM include improved probe design. The authors propose that future applications for in vivo oral CM may include burning mouth syndrome, intra-operative mapping for cancer surgery, and monitoring and targeted biopsies within field cancerization.

  12. An Inquiry Approach to Fostering Stronger Earth Science Backgrounds in Current and Future Middle and High School Science Teachers: Research Techniques as Mechanisms of Teaching Time Scales and Systems Interactions in the Earth System (United States)

    Bryce, J. G.; Finkel, E.; Froburg, E.; Graham, K.; Hale, S.; Johnson, J. E.; Varner, R. K.; von Damm, K. L.; Fellows, T.


    Earth science provides an ideal opportunity to integrate authentic research into middle and high school curricula by providing a context for teaching scientific content, promoting a sense of intrigue through the inquiry process, and sharpening skills needed for future scientific endeavors. The University of New Hampshire's offerings as part of the Transforming Earth System Science Education (TESSE) project provide for the professional development of in-service and pre-service middle and high school science teachers. A centerpiece of the TESSE program is an entry-level accelerated course in Earth Systems Science (Earth System Science for Teachers, ESST-1). Participants in the ESST-1 course include current and prospective teachers wishing to improve their Earth science content background or those interested in updating their traditional content background to include a systems approach. Time scale and system interactions significant in the Earth System are introduced through authentic research conducted during field trips, research experiences and working with long-term datasets. Teachers are trained in keeping a field notebook, making field observations, and drawing conclusions based on this evidence. Combining these techniques with digital photography, teachers document evidence of Earth system processes and their associated timescales, presenting their findings in a peer-group poster session. Teachers also participate in research-based field trips to the local estuary and a wetland research site. During the following school year, the teachers are paired with science graduate fellows to integrate inquiry- based research with existing curricula. These classroom collaborations include measurement techniques, process skills and methods of communicating evidence learned during the summer institute that are then incorporated into the classroom activities. In addition to effecting change at the curriculum-development level, the graduate fellows paired with the first

  13. Heating and current drive requirements for ideal MHD stability and ITB sustainment in ITER steady state scenarios (United States)

    Poli, Francesca


    Steady state scenarios envisaged for ITER aim at optimizing the bootstrap current, while maintaining sufficient confinement and stability to provide the necessary fusion yield. Non-inductive scenarios will need to operate with Internal Transport Barriers (ITBs) in order to reach adequate fusion gain at typical currents of 9 MA. However, the large pressure gradients associated with ITBs in regions of weak or negative magnetic shear can be conducive to ideal MHD instabilities in a wide range of βN, reducing the no-wall limit. Scenarios are established as relaxed flattop states with time-dependent transport simulations with TSC [1]. Fully non-inductive configurations with current in the range of 7-10 MA and various heating mixes (NB, EC, IC and LH) have been studied against variations of the pressure profile peaking and of the Greenwald fraction. It is found that stable equilibria have qmin> 2 and moderate ITBs at 2/3 of the minor radius [2]. The ExB flow shear from toroidal plasma rotation is expected to be low in ITER, with a major role in the ITB dynamics being played by magnetic geometry. Combinations of H&CD sources that maintain reverse or weak magnetic shear profiles throughout the discharge and ρ(qmin)>=0.5 are the focus of this work. The ITER EC upper launcher, designed for NTM control, can provide enough current drive off-axis to sustain moderate ITBs at mid-radius and maintain a non-inductive current of 8-9MA and H98>=1.5 with the day one heating mix. LH heating and current drive is effective in modifying the current profile off-axis, facilitating the formation of stronger ITBs in the rampup phase, their sustainment at larger radii and larger bootstrap fraction. The implications for steady state operation and fusion performance are discussed.[4pt] [1] Jardin S.C. et al, J. Comput. Phys. 66 (1986) 481[0pt] [2] Poli F.M. et al, Nucl. Fusion 52 (2012) 063027.

  14. Thermographic Phosphors for High Temperature Measurements: Principles, Current State of the Art and Recent Applications

    Directory of Open Access Journals (Sweden)

    Konstantinos Kontis


    Full Text Available This paper reviews the state of phosphor thermometry, focusing on developments in the past 15 years. The fundamental principles and theory are presented, and the various spectral and temporal modes, including the lifetime decay, rise time and intensity ratio, are discussed. The entire phosphor measurement system, including relative advantages to conventional methods, choice of phosphors, bonding techniques, excitation sources and emission detection, is reviewed. Special attention is given to issues that may arise at high temperatures. A number of recent developments and applications are surveyed, with examples including: measurements in engines, hypersonic wind tunnel experiments, pyrolysis studies and droplet/spray/gas temperature determination. They show the technique is flexible and successful in measuring temperatures where conventional methods may prove to be unsuitable.

  15. Current Practices in Efficiency Financing: An Overview for State and Local Governments

    Energy Technology Data Exchange (ETDEWEB)

    Leventis, Greg [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fadrhonc, Emily Martin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kramer, Chris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, Charles [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    In recent years there has been significant growth in the size and sheer number of energy efficiency financing programs. The term “energy efficiency financing” refers to debt or debt-like products that support the installation of energy efficiency measures by allowing costs to be spread over time. The implementation of the American Recovery and Reinvestment Act (ARRA) led to a proliferation of energy efficiency financing programs, which was followed in subsequent years by the launch of green banks in several states and the ramp up of other ratepayer-supported financing initiatives in various jurisdictions. These activities have brought increased attention to energy efficiency financing as an area of programmatic interest. Yet the propagation of various types of financing in a growing number of markets may have also left some policymakers and program administrators with questions as to what categories of products and programs are best suited for their situation.

  16. Approach to the current state of work harassment prevention in Colombia

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Dávila Londoño


    Full Text Available Mobbing or harassment is now recognized as a phenomenon of high impact on individuals, organizations and society. In Latin America, and specifically in Colombia, has been identified little development of thematic; this is a weakness against the possibilities to know, identify and intervene on this reality, growing in organizations. The objective of this paper is to present the results of theoretical analysis and review of prevention of mobbing in Colombia. The paper is divided into four parts. In the first, the main theoretical elements of the discussion about mobbing are synthesized. In the second, reviewed the legislation on mobbing in Colombia, and that the state has responsibilities for the identification, assessment, prevention and intervention of psychosocial risk factors at work. In a third part, presents and analyzes some measures and procedures existing prevention and intervention. Finally conclusions of the review are presented.

  17. State standards for domestic violence perpetrator treatment: current status, trends, and recommendations. (United States)

    Maiuro, Roland D; Eberle, Jane A


    We empirically surveyed and analyzed existing standards for the treatment of perpetrators of domestic violence across the United States. Specific areas examined included: presence and scope; administrative entity for certifying; screening and risk assessment protocols; minimum length of treatment; theoretical or conceptual orientation; treatment content; preferred or allowable modalities of treatment; whether research findings are mentioned; methods for revising standards; and minimum education and training required for providers. We examined trends using several methods including comparisons between present and previous survey data (Maiuro et al., 2001). Positive trends were evident including increased use of multivariate models of treatment content, use of an intake assessment prior to treatment, use of a danger/lethality assessment to manage risk, recognition of the need for program evaluation and supportive research, and the requirement of a minimum level of formal education as a prerequisite for providers. We identify specific areas for further research and development and make recommendations for improving existing practice and standards of care.


    Directory of Open Access Journals (Sweden)

    S. V. Vissarionov


    Full Text Available The article presents the historical and contemporary aspects of the state of the question correct scoliosis spine with dorsal and ventral spinal systems. The variants of spinal deformity correction method from Harrington to modern surgical techniques using both hook and metal screw. Detailed technological aspects of surgical interventions for the correction of spinal deformity using a variety of spinal structures. A comparative estimate of the correction of spinal deformity, the impact on the result of the initial mobility of the spine, level metallofiksatsii vertebral-motor segment, as well as the degree of true derotation vertebrae at the top of the curvature in a variety of surgical procedures. Describes the advantages and disadvantages of options for surgery.

  19. Thermodynamic Bethe ansatz for non-equilibrium steady states: exact energy current and fluctuations in integrable QFT (United States)

    Castro-Alvaredo, Olalla; Chen, Yixiong; Doyon, Benjamin; Hoogeveen, Marianne


    We evaluate the exact energy current and scaled cumulant generating function (related to the large-deviation function) in non-equilibrium steady states with energy flow, in any integrable model of relativistic quantum field theory (IQFT) with diagonal scattering. Our derivations are based on various recent results of Bernard and Doyon. The steady states are built by connecting homogeneously two infinite halves of the system thermalized at different temperatures Tl, Tr, and waiting for a long time. We evaluate the current J(Tl, Tr) using the exact QFT density matrix describing these non-equilibrium steady states and using Zamolodchikov’s method of the thermodynamic Bethe ansatz (TBA). The scaled cumulant generating function is obtained from the extended fluctuation relations which hold in integrable models. We verify our formula in particular by showing that the conformal field theory (CFT) result is obtained in the high-temperature limit. We analyze numerically our non-equilibrium steady-state TBA equations for three models: the sinh-Gordon model, the roaming trajectories model, and the sine-Gordon model at a particular reflectionless point. Based on the numerics, we conjecture that an infinite family of non-equilibrium c-functions, associated with the scaled cumulants, can be defined, which we interpret physically. We study the full scaled distribution function and find that it can be described by a set of independent Poisson processes. Finally, we show that the ‘additivity’ property of the current, which is known to hold in CFT and was proposed to hold more generally, does not hold in general IQFT—that is, J(Tl, Tr) is not of the form f(Tl) - f(Tr).

  20. Soil mapping and classification in the Alps: Current state and future challenges (United States)

    Baruck, Jasmin; Gruber, Fabian; Geitner, Clemens


    , following questions arise: What can we learn and adopt from existing mapping and classifications systems? Is there a basis for the development of international standards and future collaborations in the Alpine region? Against this background we give an overview of the national classification systems in the Alpine region. Additionally, a data set of soil profiles from South Tyrol will be used to show the effects of different soil classifications with special reference to topography and parent material.

  1. Cost-Effective Screening for Breast Cancer Worldwide: Current State and Future Directions

    Directory of Open Access Journals (Sweden)

    A. Sarvazyan


    Full Text Available Affordability of healthcare is highly limited by its skyrocketing cost. Access to screening and diagnostic medical equipment and medicine in developing countries is inadequate for the majority of the population. There is a tremendous worldwide need to detect breast cancer at its earliest stage. These needs must be balanced by the ability of countries to provide breast cancer screening technology to their populations. We reviewed the diagnostic accuracy, procedure cost and cost-effectiveness of currently available technique for breast screening and diagnosis including clinical breast examination, mammography, ultrasound, magnetic resonance imaging, biopsy and a new modality for cancer diagnostics termed elasticity imaging that has emerged in the last decade. Clinical results demonstrate that elasticity imaging even in its simplest and least sophisticated versions, like tactile imaging, has significant diagnostic potential comparable and exceeding that of conventional imaging techniques. In view of many countries with limited resources, effective yet less expensive modes of screening must be considered worldwide. The tactile imaging is one method that has the potential to provide cost-effective breast cancer screening and diagnostics.

  2. Specimen banking of marine organisms in the United States: current status and long-term prospective. (United States)

    Becker, P R; Wise, S A; Thorsteinson, L; Koster, B J; Rowles, T


    A major part of the activities conducted over the last decade by the National Biomonitoring Specimen Bank (NBSB) has involved the archival of marine specimens collected by ongoing environmental monitoring programs. These archived specimens include bivalves, marine sediments, and fish tissues collected by the National Status and Trends and the Exxon Valdez Oil Spill Damage Assessment programs, and marine mammal tissues collected by the Marine Mammal Health and Stranding, Response Program and the Alaska Marine Mammal Tissue Archival Project. In addition to supporting these programs, the specimens have been used to investigate circumpolar patterns of chlorinated hydrocarbon concentrations, genetic separation of marine animal stocks, baseline levels of essential and nonessential elements in marine mammals, and the potential risk to human consumers in the Arctic from anthropogenic contaminants found in local subsistence foods. The NBSB specimens represent a resource that has the potential for addressing future issues of marine environmental quality and ecosystem changes through retrospective analysis; however, an ecosystem-based food web approach would maximize this potential. The current status of the NBSB activities related to the banking of marine organisms is presented and discussed, the long-term prospective of these activities is presented, and the importance of an ecosystem-based food web monitoring approach to the value of specimen banking is discussed.

  3. Specimen banking of marine organisms in the United States: Current status and long-term prospective (United States)

    Becker, P.R.; Wise, S.A.; Thorsteinson, L.; Koster, B.J.; Rowles, T.


    A major part of the activities conducted over the last decade by the National Biomonitoring Specimen Bank (NBSB) has involved the archival of marine specimens collected by ongoing environmental monitoring programs. These archived specimens include bivalves, marine sediments, and fish tissues collected by the National Status and Trends and the Exxon Valdez Oil Spill Damage Assessment programs, and marine mammal tissues collected by the Marine Mammal Health and Stranding Response Program and the Alaska Marine Mammal Tissue Archival Project. In addition to supporting these programs, the specimens have been used to investigate circumpolar patterns of chlorinated hydrocarbon concentrations, genetic separation of marine animal stocks, baseline levels of essential and nonessential elements in marine mammals, and the potential risk to human consumers in the Arctic from anthropogenic contaminants found in local subsistence foods. The NBSB specimens represent a resource that has the potential for addressing future issues of marine environmental quality and ecosystem changes through retrospective analysis; however, an ecosystem-based food web approach would maximize this potential. The current status of the NBSB activities related to the banking of marine organisms is presented and discussed, the long-term prospective of these activities is presented, and the importance of an ecosystem-based food web monitoring approach to the value of specimen banking is discussed.

  4. Critical Current Oscillations in the Intrinsic Hybrid Vortex State of SmFeAs(O,F) (United States)

    Moll, Philip J. W.; Balicas, Luis; Zhu, Xiyu; Wen, Hai-Hu; Zhigadlo, Nikolai D.; Karpinski, Janusz; Batlogg, Bertram


    In layered superconductors the order parameter may be modulated within the unit cell, leading to nontrivial modifications of the vortex core if the interlayer coherence length ξc(T ) is comparable to the interlayer spacing. In the iron pnictide SmFeAs(O,F) (Tc≈50 K ) this occurs below a crossover temperature T⋆≈41 K , which separates two regimes of vortices: anisotropic Abrikosov-like at high and Josephson-like at low temperatures. Yet in the transition region around T⋆ , hybrid vortices between these two characteristics appear. Only in this region around T⋆ and for magnetic fields well aligned with the FeAs layers, we observe oscillations of the c -axis critical current jc(H ) periodic in 1 /√{H } due to a delicate balance of intervortex forces and interaction with the layered potential. jc(H ) shows pronounced maxima when a hexagonal vortex lattice is commensurate with the underlying crystal structure. The narrow temperature window in which oscillations are observed suggests a significant suppression of the order parameter between the superconducting layers in SmFeAs(O,F), despite its low coherence length anisotropy (γξ≈3 - 5 ).

  5. Experimental pain processing in individuals with cognitive impairment: current state of the science. (United States)

    Defrin, Ruth; Amanzio, Martina; de Tommaso, Marina; Dimova, Violeta; Filipovic, Sasa; Finn, David P; Gimenez-Llort, Lydia; Invitto, Sara; Jensen-Dahm, Christina; Lautenbacher, Stefan; Oosterman, Joukje M; Petrini, Laura; Pick, Chaim G; Pickering, Gisele; Vase, Lene; Kunz, Miriam


    Cognitive impairment (CI) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with CI have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals with CI can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with CI to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which CI is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with CI compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of CI (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of CI, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of CI, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in CI will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with CI.

  6. Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art. (United States)

    Rahman, Mahfoozur; Kumar, Vikas; Beg, Sarwar; Sharma, Gajanand; Katare, Om Prakash; Anwar, Firoz


    Inflammatory diseases are considered to be highly dreadful ones responsible for higher mortality in the developed countries. This includes cancer, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. The tremendous strides in the area of drug development to find newer molecules like non-steroidal and steroidal agents and immunosuppressant agents delivered by conventional formulation. These therapy have enhances the life expectancy of patient, but it provide the therapeutic benefits only to a limited extent. Recent advancement in liposomes based nanomedicines has led to the possibility of improves the efficacy and safety of the pharmacotherapy of inflammatory disorders. Of late, liposomes have been highly explored as one of the promising systems for delivering numerous anti-inflammatory drugs for attaining enhanced therapeutic outcomes. Over the conventional carriers, liposomal systems have numerous drug delivery merits including advantages in both passive and active targeting of drug molecules to the inflammatory lesions. The current review article, therefore, endeavors to provide a bird's eye view account on the success of liposome-based therapeutic systems in the management of dreadful inflammatory disorders along with updated knowledge to pharmaceutical scientists in the field.

  7. Current state of particulate matter research and management in Serbia (Introductory paper

    Directory of Open Access Journals (Sweden)

    Milena Jovašević-Stojanović


    Full Text Available Particulate matter is the air pollutant that currently receives most attention from the atmospheric research community, the legislative authorities and the general public. Limiting particulate matter in the atmosphere which will result in significant benefits for human health, with associated positive economic consequences. Successful management of particulate matter requires scientific knowledge about particulate matter “from cradle to grave”, covering sources of particles, processes that govern their formation, composition, dispersion and fate in the atmosphere, as well as knowledge about human exposure and associated health and well being. Such knowledge allows to design and perform effective and efficient abatement measures and monitoring. This paper provides an introduction to the research and monitoring regarding particulate matter in Serbia. The contributions were first partly presented at the 2nd international workshop of the WeBIOPATR “Outdoor concentration, size distribution and composition of respirable particles in WB urban area” project in September 2009. This information provides context to the contributions in this number, and was part of the rationale of the project WeBIOPATR.

  8. Application of light-emitting diodes (LEDs) in cultivation of phototrophic microalgae: current state and perspectives. (United States)

    Glemser, M; Heining, M; Schmidt, J; Becker, A; Garbe, D; Buchholz, R; Brück, T


    The quality and regulation of the incident light is crucial in microalgae cultivation processes. Depending on wavelength, spectrum, and intensity, growth characteristics and biochemical composition of these organisms vary. With mainly fluorescent lamps (FL) used previously for illumination, such variabilities could not be studied adequately due to their broad emission spectrum. In contrast, light-emitting diodes (LEDs) emit a very narrow wavelength band and enable flexible photobioreactor designs due to their small size. This review provides a condensed overview on the application of LEDs in microalgal cultivation processes. It summarizes the current availability and applicability of LED technologies as an illumination source for research-focused photobioreactor systems. A particular focus is the use of narrow-wavelength LEDs to address fundamental as well as applied aspects of light color on algae biomass and value-added compound formation. In this respect, the application of internal and external illumination systems is reviewed together with trends in the industrial use of LED systems to intensify algae process efficiency.

  9. Intraoperative fluorescence imaging for personalized brain tumor resection: Current state and future directions

    Directory of Open Access Journals (Sweden)

    Evgenii Belykh


    Full Text Available Introduction: Fluorescence-guided surgery is one of the rapidly emerging methods of surgical theranostics. In this review, we summarize current fluorescence techniques used in neurosurgical practice for brain tumor patients, as well as future applications of recent laboratory and translational studies.Methods: Review of the literature.Results: A wide spectrum of fluorophores that have been tested for brain surgery is reviewed. Beginning with a fluorescein sodium application in 1948 by Moore, fluorescence guided brain tumor surgery is either routinely applied in some centers or is under active study in clinical trials. Besides the trinity of commonly used drugs (fluorescein sodium, 5-ALA and ICG, less studied fluorescent stains, such as tetracyclines, cancer-selective alkylphosphocholine analogs, cresyl violet, acridine orange, and acriflavine can be used for rapid tumor detection and pathological tissue examination. Other emerging agents such as activity-based probes and targeted molecular probes that can provide biomolecular specificity for surgical visualization and treatment are reviewed. Furthermore, we review available engineering and optical solutions for fluorescent surgical visualization. Instruments for fluorescent-guided surgery are divided into wide-field imaging systems and hand-held probes. Recent advancements in quantitative fluorescence-guided surgery are discussed.Conclusion: We are standing on the doorstep of the era of marker-assisted tumor management. Innovations in the fields of surgical optics, computer image analysis, and molecular bioengineering are advancing fluorescence-guided tumor resection paradigms, leading to cell-level approaches to visualization and resection of brain tumors.

  10. School Social Work in the United States: Current Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Stone, Susan


    Full Text Available This paper surveys the historical and school institutional factors that shape current workforce, programmatic, and practice trends related to school social work in America. A key strand developed throughout is that the field of practice appears to be at a crossroads. It is suggested that this field of practice may be enhanced by placing the central focus on schools as organisations and school-community relations as key targets of intervention.Este artículo examina los factores históricos e institucionales que perfilan al personal docente, las tendencias en las programaciones y las prácticas que se desarrollan en la actualidad en el ámbito del trabajo social en la escuela en los Estados Unidos de América. Un aspecto clave derivado de este examen es que la profesión parece estar en una encrucijada. Se sugiere como alternativa a esta situación, centrar la atención y los objetivos fundamentales de intervención en las escuelas como organizaciones, y en las relaciones que se generan entre las escuelas y la comunidad.

  11. [Patient-centredness in rehabilitation : an overview on the current state of research]. (United States)

    Farin, E


    This article provides an overall perspective of the concept of patient-centredness in health care. After discussing the social factors that significantly contribute to this topic, the authors refer to a definition by Mead and Bower in their understanding of patient-centredness. They distinguished five facets of patient-centredness, namely the biopsychosocial perspective, seeing the patient as an individual person, sharing power and responsibility (e.g. shared decision-making), consideration of the patient-treatment provider relationship and regarding the treatment provider as a person. The authors discuss why approaches employing patient-centred care seem particularly well-suited to a rehabilitation context and emphasize the value and benefit of patient-centred care. They describe those areas currently engaging the greatest research efforts in Germany by providing an overview of projects now being conducted in the funding priority for chronic illnesses and patient orientation. In the final chapter the authors consider the need for further research as well as the potential adverse side effects associated with intensified patient-centred care.

  12. Structural dynamics of microsystems—current state of research and future directions (United States)

    Lin, R. M.; Wang, W. J.


    Microsystems or micro-electro-mechanical systems (MEMS), as a newly emerged revolutionary enabling technology, has brought both opportunities and challenges to the field of structural dynamics in a different scale, owing primarily to its interdisciplinary nature of research and extremely small feature size. This paper seeks to present a comprehensive yet critical review on some of the major issues that need to be tackled in the successful realisation of microsystems, with an ultimate objective of further developing and improving the current design capabilities of these systems. The electro-mechanical coupling of typical MEMS devices is first defined and introduced, followed by an in-depth review of the various existing modeling and simulation techniques. Special requirements are discussed when typical MEMS devices need to be tested and existing vibration testing techniques are reviewed. Of particular interest to MEMS devices, structural damping has become a major issue affecting dynamic performance due to the various energy dissipation mechanisms involved. These damping mechanisms have been examined, together with methods developed to model them. Finally, conclusions are made on what have been achieved to date and future prospects of structural dynamics of Microsystems are identified with an intention to stimulate further concerted research in this important emerging area.

  13. The current state of knowledge about shatter cones: Introduction to the special issue (United States)

    Baratoux, David; Reimold, Wolf Uwe


    Shatter cones are a fracture phenomenon that is exclusively associated with shock metamorphism and has also been produced in the laboratory in several shock experiments. The occurrence of shatter cones is the only accepted meso- to macroscopic recognition criterion for impact structures. Shatter cones exhibit a number of geometric characteristics (orientation, apical angles, striation angles, sizes) that can be best described as varied, from case to case. Possible links between geometric properties with impact or crater parameters have remained controversial and the lack of understanding of the mechanism of formation of shatter cones does not offer a physical framework to discuss or understand them. A database of shatter cone occurrences has been produced for this introduction paper to the special issue of Meteoritics and Planetary Science on shatter cones. Distribution of shatter cones with respect to crater size and lithology suggests that shatter cones do not occur in impact craters less than a few kilometers in diameter, with a few, currently questionable exceptions. All pertinent hypotheses of formation are presented and discussed. Several may be discarded in light of the most recent observations. The branching fracture mechanism and the interference models proposed, respectively, by Sagy et al. (2002) and Baratoux and Melosh (2003) require further evaluation. New observations, experiments, or theoretical considerations presented in this special issue promise an important step forward, based on a renewed effort to resolve the enigmatic origin of these important features.

  14. Progress of information technology in healthcare, current state, outlook toward future

    Directory of Open Access Journals (Sweden)

    Miroslav Dvořák


    Full Text Available Brief summary of reasons for development of Hospital Information Systems (HIS is described. We mention different concepts of HIS development. Primary negative attitude of physicians to the invasion of information technology to hospitals has been slowly changed. Extended teaching of fundamentals of computer science at medical universities is very important for a new generation of physicians. Modern methods of e‑learning allow using websites and medical atlases including presentations of surgical interventions in different branches of surgical medicine, physiotherapeutic methods, etc. Medical staff in hospitals may also profit from electronic tools used for education in medical informatics or for obligatory postgraduate courses. Software producing companies are obliged to teach potential users how to use implemented information systems effectively. E-learning is a good method how to teach new employees who need to start using the system. Telematics in health service and use of Internet data storages may be a trend in future development of information systems. Large amount of patient data in current databases is a big encouragement for expanded use of data mining and application of artificial intelligence methods in medical expert systems.

  15. The community of needle endophytes reflects the current physiological state of Norway spruce. (United States)

    Rajala, Tiina; Velmala, Sannakajsa M; Vesala, Risto; Smolander, Aino; Pennanen, Taina


    This study investigated fungal endophytes in the needles of Norway spruce (Picea abies) cuttings in relation to host tree growth. We also determined the prevalence of endophytes in needles incubated for six months. The cuttings originated from clonal origins showing slow- and fast-growth in long-term field trials but the heritable differences in growth rate were not yet detected among the studied cutting. Endophytes were isolated from surface-sterilized needles with culture-free DNA techniques. No significant differences were observed between endophyte communities of slow- and fast-growing clonal origins. However, the endophyte community correlated with the current growth rate of cuttings suggesting that endophytes reflect short- rather than long-term performance of a host. The concentration of condensed tannins was similar in slow- and fast-growing clonal origins but it showed a negative relationship with endophyte species richness, implying that these secondary compounds may play an important role in spruce tolerance against fungal infections. More than a third of endophyte species were detected in both fresh and decomposing needles, indicating that many needle endophytes are facultative saprotrophs. Several potentially pathogenic fungal species were also found within the community of saprotrophic endophytes.

  16. Current state of practice regarding testosterone supplementation therapy in men with prostate cancer. (United States)

    Kovac, Jason R; Pan, Michael M; Lipshultz, Larry I; Lamb, Dolores J


    Hypogonadal men are characterized by low serum testosterone and symptoms of low energy, decreased libido, and muscle mass as well as impaired concentration and sexual functioning. Men with prostate cancer (PCa) currently on active surveillance or post-therapy, have traditionally been excluded from management paradigms given the decade-old concern that testosterone caused PCa growth. However, there appears to be little or no relationship between serum testosterone concentration and PCa. Androgen action in the prostate has long been known to be affected by the kinetics of receptor saturation and, as such, testosterone beyond a certain baseline is unable to stimulate prostatic growth due to complete intra-prostatic androgen receptor binding. Given this physiologic concept, many clinical investigators have begun to promote testosterone supplementation therapy (TST) as safe in men with PCa. This review examines the basics of testosterone physiology and summarizes the most recent findings on the use of TST in men with PCa on active surveillance and following treatment with external beam radiotherapy, brachytherapy and radical prostatectomy.

  17. The current state of the Russian reduced enrichment research reactors program

    Energy Technology Data Exchange (ETDEWEB)

    Aden, V.G.; Kartashov, E.F.; Lukichev, V.A. [and others


    During the last year after the 16-th International Conference on Reducing Fuel Enrichment in Research Reactors held in October, 1993 in Oarai, Japan, the conclusive stage of the Program on reducing fuel enrichment (to 20% in U-235) in research reactors was finally made up in Russia. The Program was started late in 70th and the first stage of the Program was completed by 1986 which allowed to reduce fuel enrichment from 80-90% to 36%. The completion of the Program current stage, which is counted for 5-6 years, will exclude the use of the fuel enriched by more than 20% from RF to other countries such as: Poland, Czeck Republick, Hungary, Roumania, Bulgaria, Libya, Viet-Nam, North Korea, Egypt, Latvia, Ukraine, Uzbekistan and Kazakhstan. In 1994 the Program, approved by RF Minatom authorities, has received the status of an inter-branch program since it was admitted by the RF Ministry for Science and Technical Policy. The Head of RF Minatom central administrative division N.I.Ermakov was nominated as the Head of the Russian Program, V.G.Aden, RDIPE Deputy Director, was nominated as the scientific leader. The Program was submitted to the Commission for Scientific, Technical and Economical Cooperation between USA and Russia headed by Vice-President A. Gore and Prime Minister V. Chemomyrdin and was given support also.

  18. Genetic linkage mapping in fungi: current state, applications, and future trends. (United States)

    Foulongne-Oriol, Marie


    Genetic mapping is a basic tool for eukaryotic genomic research. Linkage maps provide insights into genome organization and can be used for genetic studies of traits of interest. A genetic linkage map is a suitable support for the anchoring of whole genome sequences. It allows the localization of genes of interest or quantitative trait loci (QTL) and map-based cloning. While genetic mapping has been extensively used in plant or animal models, this discipline is more recent in fungi. The present article reviews the current status of genetic linkage map research in fungal species. The process of linkage mapping is detailed, from the development of mapping populations to the construction of the final linkage map, and illustrated based on practical examples. The range of specific applications in fungi is browsed, such as the mapping of virulence genes in pathogenic species or the mapping of agronomically relevant QTL in cultivated edible mushrooms. Future prospects are finally discussed in the context of the most recent advances in molecular techniques and the release of numerous fungal genome sequences.

  19. Managing Carbon Regulatory Risk in Utility Resource Planning:Current Practices in the Western United States

    Energy Technology Data Exchange (ETDEWEB)

    Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles


    Concerns about global climate change have substantially increased the likelihood that future policy will seek to minimize carbon dioxide emissions. Assuch, even today, electric utilities are making resource planning and investment decisions that consider the possible implications of these future carbon regulations. In this article, we examine the manner in which utilities assess the financial risks associated with future carbon regulations within their long-term resource plans. We base our analysis on a review of the most recent resource plans filed by fifteen electric utilities in the Western United States. Virtually all of these utilities made some effort to quantitatively evaluate the potential cost of future carbon regulations when analyzing alternate supply- and demand-side resource options for meeting customer load. Even without Federal climate regulation in the U.S., the prospect of that regulation is already having an impact on utility decision-making and resource choices. That said, the methods and assumptions used by utilities to analyze carbon regulatory risk, and the impact of that analysis on their choice of a particular resource strategy, vary considerably, revealing a number of opportunities for analytic improvement. Though our review focuses on a subset of U.S. electric utilities, this work holds implications for all electric utilities and energy policymakers who are seeking to minimize the compliance costs associated with future carbon regulations

  20. Managing Carbon Regulatory Risk in Utility Resource Planning: Current Practices in the Western United States

    Energy Technology Data Exchange (ETDEWEB)

    Barbose, Galen; Wiser, Ryan; Phadke, Amol; Goldman, Charles


    Concerns about global climate change have substantially increased the likelihood that future policy will seek to minimize carbon dioxide emissions. As such, even today, electric utilities are making resource planning and investment decisions that consider the possible implications of these future carbon regulations. In this article, we examine the manner in which utilities assess the financial risks associated with future carbon regulations within their long-term resource plans. We base our analysis on a review of the most recent resource plans filed by fifteen electric utilities in the Western United States. Virtually all of these utilities made some effort to quantitatively evaluate the potential cost of future carbon regulations when analyzing alternate supply- and demand-side resource options for meeting customer load. Even without Federal climate regulation in the U.S., the prospect of that regulation is already having an impact on utility decision-making and resource choices. That said, the methods and assumptions used by utilities to analyze carbon regulatory risk, and the impact of that analysis on their choice of a particular resource strategy, vary considerably, revealing a number of opportunities for analytic improvement. Though our review focuses on a subset of U.S. electric utilities, this work holds implications for all electric utilities and energy policymakers who are seeking to minimize the compliance costs associated with future carbon regulations.

  1. Strained local and state government finances among current realities that threaten public hospitals' profitability. (United States)

    Kane, Nancy M; Singer, Sara J; Clark, Jonathan R; Eeckloo, Kristof; Valentine, Melissa


    This study demonstrates that some safety-net hospitals--those that provide a large share of the care to low-income, uninsured, and Medicaid populations--survived and even thrived before the recent recession. We analyzed the financial performance and governance of 150 hospitals during 2003-07. We found, counterintuitively, that those directly governed by elected officials and in highly competitive markets were more profitable than other safety-net hospitals. They were financially healthy primarily because they obtained subsidies from state and local governments, such as property tax transfers or supplemental Medicaid payments, including disproportionate share payments. However, safety-net hospitals now face a new market reality. The economic downturn, slow recovery, and politics of deficit reduction have eroded the ability of local governments to support the safety net. Many safety-net hospitals have not focused on effective management, cost control, quality improvement, or services that attract insured patients. As a result, and coupled with new uncertainties regarding Medicaid expansion stemming from the recent Supreme Court decision on the Affordable Care Act, many are likely to face increasing financial and competitive pressures that may threaten their survival.

  2. N2O emissions from the global agricultural nitrogen cycle – current state and future scenarios

    Directory of Open Access Journals (Sweden)

    H. Lotze-Campen


    Full Text Available Reactive nitrogen (Nr is not only an important nutrient for plant growth, thereby safeguarding human alimentation, but it also heavily disturbs natural systems. To mitigate air, land, aquatic, and atmospheric pollution caused by the excessive availability of Nr, it is crucial to understand the long-term development of the global agricultural Nr cycle. For our analysis, we combine a material flow model with a land-use optimization model. In a first step we estimate the state of the Nr cycle in 1995. In a second step we create four scenarios for the 21st century in line with the SRES storylines. Our results indicate that in 1995 only half of the Nr applied to croplands was incorporated into plant biomass. Moreover, less than 10 per cent of all Nr in cropland plant biomass and grazed pasture was consumed by humans. In our scenarios a strong surge of the Nr cycle occurs in the first half of the 21st century, even in the environmentally oriented scenarios. Nitrous oxide (N2O emissions rise from 3 Tg N2O-N in 1995 to 7–9 in 2045 and 5–12 Tg in 2095. Reinforced Nr pollution mitigation efforts are therefore required.


    Directory of Open Access Journals (Sweden)

    M. D. Ananicheva


    Full Text Available SummaryPaper presents the results of interpretation of space images (from Landsat and World View-2, which made possible to estimate the areal extent of glaciers ofMeynypilgynskyRange, North-East of Koryak Upland, in the early 2000's. Assessments of glaciers were analyzed in comparison with the Glacier Inventory of the region, compiled by R.V. Sedov (2001, as a whole and for groups of glaciers belonging to the selected six glacial systems. After dozens of years since the compilation of the Inventory (1985 and from some glacier data referred to 1967, the glaciers ofMeynypilgynskyRangelost about 30% of the area, mainly due to drying that accompanies climate warming. The analysis of glaciers, which had retreated, was conducted for the groups by the same morphological type, and the same aspect. The largest retreat and area reduction is relevant to valley-corrie and hanging glaciers of eastern aspect. Glaciers facing north less suffered. As a result of application of the developed methodology for assessing the evolution of glacier systems under given climate scenario, the parameters for the state of the glacier systems ofMeynypilgynskyRangeup to the time span 2049–2060 were obtained. The AOGCM–ECHAM 5 (B1 was used as a scenario; it is the optimal for theNorthern Eurasia. It turned out that the glaciers reduction would be catastrophic (about 90%, but nevertheless they would not completely disappeared.

  4. Advances in hepatitis C therapy: What is the current state -what come's next?

    Institute of Scientific and Technical Information of China (English)


    Chronic hepatitis C virus (HCV) infection affects 80-160million people worldwide and is one of the leadingcauses of chronic liver disease. It is only a few yearsago that standard treatment regimes were based onpegylated interferon alpha and ribavirin. However,treatment of HCV has undergone a revolutionary changein recent years. The admission of the nucleotide polymeraseinhibitor Sofosbuvir enabled an interferon-freeregimen with direct antiviral agents (DAA). Meanwhileseven DAAs are available and can be applied in severalcombinations for 8 to 24 wk depending on HCV genotypeand patient characteristics such as cirrhosis and chronicrenal failure. High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patientswith liver cirrhosis, HCV-human immunodeficiency virusco-infections, after liver transplantion, or with chronickidney disease comparable high rates of SVR can beachieved. The anticipated 2nd generation DAAs arestrikingly effective in patients so far classified as difficultto treat including decompensated liver cirrhosis or posttransplantpatients. These 2nd generations DAAs will havehigher resistance barriers, higher antiviral effects anda pan-genotypic spectrum. This review highlights thecurrent state of the art of antiviral treatment in hepatitisC and gives an outlook for upcoming therapies.

  5. The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

    Directory of Open Access Journals (Sweden)

    Xiaoyuan Miao


    Full Text Available Macrophages are vital regulators of the host defense in organisms. In response to different local microenvironments, resting macrophages (M0 can be polarized into different phenotypes, pro-inflammatory (M1 or anti-inflammatory (M2, and perform different roles in different physiological or pathological conditions. Polarized macrophages can also be further reprogrammed by reversing their phenotype according to the changed milieu. Macrophage polarization and reprogramming play essential roles in maintaining the steady state of the immune system and are involved in the processes of many diseases. As foreign substances, nanoparticles (NPs mainly target macrophages after entering the body. NPs can perturb the polarization and reprogramming of macrophages, affect their immunological function and, therefore, affect the pathological process of disease. Optimally-designed NPs for the modulation of macrophage polarization and reprogramming might provide new solutions for treating diseases. Systematically investigating how NPs affect macrophage polarization is crucial for understanding the regulatory effects of NPs on immune cells in vivo. In this review, macrophage polarization by NPs is summarized and discussed.


    Directory of Open Access Journals (Sweden)

    I. A. Istomin


    Full Text Available 2000’s and 2010’s witnessed diminishing margin of the United States in science and technology. Meanwhile, the U.S. remains a clear leader in this fi eld. Major driving force of the country’s success in the second half of the ХХ century remained assertive federal science policy. The article seeks to identify major trends in evolution of the U.S. science policy and the reasons behind relative decline of the level of budget support of the scientifi c research. The author studies evolution of the policies of George Bush and Barack Obama, as well as the views of Democrats and Republicans in the House of Representatives and the Senate. The article also examines the input into the federal policy of the governmental bodies, which are directly responsible for its implementation, as well as non-governmental organizations, which seek to advocate interests of scientists; it studies rising competition between the executive authorities and legislators for the recognition as a major champion of the academic community as well as American Recovery and Reinvestment Act.


    Directory of Open Access Journals (Sweden)

    Elena Konstantinovna Hetman


    Full Text Available The state policy of modern Russia clearly formulated in the framework of «Strategy of innovative development of the Russian Federation until 2020», one of the priorities determines the development of human resources in science, education, technologies and innovations. Pursuant to the requirements of modern business, the system of higher professional education aimed at training of competitive graduates, the distinguishing quality of which is not only a high level of knowledge and skills, but also the development/implementation of innovations in professional activity. In work the analysis of modern condition of a problem of formation of innovative competence, summed up the experience of researchers on the issues of the competence approach the formation of professional and General cultural competences. Presents the dependence of the level of preparation of bachelors and the formation of different kinds of innovation. The basic components of innovation. Also describes the basic qualities of innovative thinking of the bachelor-engineer, given the author’s definition of innovation competencies.

  8. Dynamic causal models of neural system dynamics: current state and future extensions

    Indian Academy of Sciences (India)

    Klaas E Stephan; Lee M Harrison; Stefan J Kiebel; Olivier David; Will D Penny; Karl J Friston


    Complex processes resulting from interaction of multiple elements can rarely be understood by analytical scientific approaches alone; additional, mathematical models of system dynamics are required. This insight, which disciplines like physics have embraced for a long time already, is gradually gaining importance in the study of cognitive processes by functional neuroimaging. In this field, causal mechanisms in neural systems are described in terms of effective connectivity. Recently, dynamic causal modelling (DCM) was introduced as a generic method to estimate effective connectivity from neuroimaging data in a Bayesian fashion. One of the key advantages of DCM over previous methods is that it distinguishes between neural state equations and modality-specific forward models that translate neural activity into a measured signal. Another strength is its natural relation to Bayesian model selection (BMS) procedures. In this article, we review the conceptual and mathematical basis of DCM and its implementation for functional magnetic resonance imaging data and event-related potentials. After introducing the application of BMS in the context of DCM, we conclude with an outlook to future extensions of DCM. These extensions are guided by the long-term goal of using dynamic system models for pharmacological and clinical applications, particularly with regard to synaptic plasticity.

  9. Neuroimaging training among neuropsychologists: a survey of the state of current training and recommendations for trainees. (United States)

    Benitez, Andreana; Hassenstab, Jason; Bangen, Katherine J


    Neuroimaging has gained widespread use in neuropsychological research and practice. However, there are neither established guidelines on how neuropsychologists might become competent researchers or consumers of neuroimaging data, nor any published studies describing the state of neuroimaging training among neuropsychologists. We report the results of two online surveys, one of 13 expert neuropsychologist-neuroimagers whose responses informed the formulation of a second, larger survey to neuropsychologists-at-large that were a random selection of a third of the members of the International Neuropsychological Society and American Academy of Clinical Neuropsychology. A total of 237 doctoral-level neuropsychologists, or 15.3% of potential participants, provided complete responses. Most respondents (69.2%) received training in neuroimaging, mostly at the post-doctoral level, largely through independent study, clinical conferences, instruction by clinical supervisors, and individualized mentoring, on topics such as neuroimaging modalities in neurology, neuroanatomy, and the appropriate information to glean from neuroradiology reports. Of the remaining respondents who did not receive training in neuroimaging, 64.4% indicated that such training would be very or extremely beneficial to one's career as a neuropsychologist. Both neuropsychologist-neuroimagers and neuropsychologists-at-large provided specific recommendations for training. Findings from this initial effort will guide trainees who seek to develop competence in neuroimaging, and inform future formulations of neuropsychological training.

  10. State and local levels of preparedness for terrorist incidents : the current and sobering U.S. picture

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, G. [New Jersey Univ. of Medicine and Dentistry, New Brunswick, NJ (United States). School of Public Health; Scott, C.M.; Scott-Dimenna, D. [Rutgers Univ., New Brunswick, NJ (United States)


    An increasing number of professional organizations and foundations have surveyed components of the United States readiness programs concerning preparedness for terrorist attacks. This paper reviews the results of research conducted in 2002 and compares them with subsequent studies, demonstrating a gap between desired and current states of readiness. Weaknesses at the local, federal and state levels were discussed. Results from local needs and preparedness surveys were examined, including details and summaries of surveys sent to representatives within all states and territories. Significant gaps still remained in protecting the public from biological and chemical attacks. Cut-backs and a lack of resources were identified as contributing to a lack of local preparedness. In addition, emergency responders were not receiving appropriate training. An independent task force reported that less than 10 per cent of fire departments in the United States had the resources, training and equipment needed to respond to a building collapse. It was noted that less than one-quarter of the United States are able to respond 24 hours a day to reports from hospitals of possible victims of biological or chemical attacks. Bioterrorism preparedness still lacks strategic direction, well-defined priorities and appropriate levels of resources to match needs. In addition, although facilities have been identified as risk management program sites, local responders remain unprepared for threats and many local fire and police departments have not been informed of specific plant hazards or information regarding exact chemical hazards. It was concluded that as the United States approaches its fourth anniversary of the 9/11 attacks, there is is much yet to be done to improve the level of preparedness in cities and towns across the country. 31 refs., 2 tabs.

  11. State of the art of superconducting fault current limiters and their application to the electric power system (United States)

    Morandi, Antonio


    Modern electric power systems are becoming more and more complex in order to meet new needs. Nowadays a high power quality is mandatory and there is the need to integrate increasing amounts of on-site generation. All this translates in more sophisticated electric network with intrinsically high short circuit rate. This network is vulnerable in case of fault and special protection apparatus and procedures needs to be developed in order to avoid costly or even irreversible damage. A superconducting fault current limiter (SFCL) is a device with a negligible impedance in normal operating conditions that reliably switches to a high impedance state in case of extra-current. Such a device is able to increase the short circuit power of an electric network and to contemporarily eliminate the hazard during the fault. It can be regarded as a key component for future electric power systems. In this paper the state of the art of superconducting fault current limiters mature for applications is briefly resumed and the potential impact of this device on the paradigm of design and operation of power systems is analyzed. In particular the use of the FCL as a mean to allow more interconnection of MV bus-bars as well an increased immunity with respect to the voltage disturbances induced by critical customer is discussed. The possibility to integrate more distributed generation in the distribution grid is also considered.

  12. On the current state of the Hydrologic Evaluation of Landfill Performance (HELP) model. (United States)

    Berger, Klaus U


    The Hydrologic Evaluation of Landfill Performance (HELP) model is the most widely applied model to calculate the water balance of cover and bottom liner systems for landfills. The paper summarizes the 30 year history of the model from HELP version 1 to HELP 3.95 D and includes references to the three current and simultaneously available versions (HELP 3.07, Visual HELP 2.2, and HELP 3.95 D). A sufficient validation is an essential precondition for the use of any model in planning. The paper summarizes validation approaches for HELP 3 focused on cover systems in the literature. Furthermore, measurement results are compared to simulation results of HELP 3.95 D for (1) a test field with a compacted clay liner in the final cover of the landfill Hamburg-Georgswerder from 1988 to 1995 and (2) a test field with a 2.3m thick so-called water balance layer on the landfill Deetz near Berlin from 2004 to 2011. On the Georgswerder site actual evapotranspiration was well reproduced by HELP on the yearly average as well as in the seasonal course if precipitation data with 10% systematic measurement errors were used. However, the increase of liner leakage due to the deterioration of the clayey soil liner was not considered by the model. On the landfill Deetz HELP overestimated largely the percolation through the water balance layer resulting from an extremely wet summer due to an underestimation of the water storage in the layer and presumably also due to an underestimation of the actual evapotranspiration. Finally based on validation results and requests from the practice, plans for improving the model to a future version HELP 4 D are described.

  13. Extrapolational Look at the Current State of Territorial Strategic Planning in Russia

    Directory of Open Access Journals (Sweden)

    Bogomolova Irina Viktorovna


    suggestions for improvement and revision of current law, including the adoption of additional regulatory legal acts of methodological character.

  14. [J. Delay hypothymic disorder. Current aspects and pertinence of the concept in schizophrenic states]. (United States)

    Dollfus, S; Petit, M


    In the first part, the authors re-examined the concept of "hypothymie" described by J. Delay in 1946. "Hypothymie" is characterized by a mood disorder and particularly by an absence of mood and it is a fundamental syndrome of hebephrenia. From this syndrome "hypothymie", others signs will appear such as schizophrenic symptoms (characterized by attention disorder and formal thought disorder), paranoid symptoms or catatonic ones. Several authors, like J. Delay, had emphasized the importance of the mood disorder (an absence) in this pathology. It is the case of Kretschmer, Dide and Guiraud (who evoked the "athymhormie"), Bleuler, Kraepelin and also Stransky, Griesinger and at the beginning of the XIXth century, Haslam in England and Pinel in France. In the present time, "hypothymie" is related to some current concepts, especially the deficit forms of schizophrenia described by Carpenter and the schizophrenia type II defined by Crow. In the second part, the relationships between paranoid symptoms, depression and "hypothymie" were studied. The authors stressed the fact that there is an overlap between depressive and paranoid symptoms at the acute phase. They gave an illustration including 51 patients in an acute phase and in a stabilized one. In the acute phase, there was a negative correlation between positive symptoms and depressive symptoms in particular between conceptual disorganization, suspiciousness/persecution, positive formal thought disorder and depression (r = -0.65, p < 0.01; r = -0.57, p < 0.01; r = -0.66, p < 0.01 respectively). These correlations disappeared at discharge of the hospital and did not exist in the stabilized group.(ABSTRACT TRUNCATED AT 250 WORDS)

  15. Current State of Clinical Studies on Diagnosis and Treatment of Sudden Deafness in China

    Institute of Scientific and Technical Information of China (English)

    YU Yaping; YANG Shiming; GUO Wei; YANG Weiyan; GU Rui


    Objective To evaluate the current status of clinical studies on diagnosis and treatment of sudden deafness (SD) in China by retrospective reviewing articles on SD published in Chinese journals in the past 5 years.Special attention is given to whether the diagnosis and treatment standards established in 1996 by the otolaryngology branch of Chinese Medical Association (the"1996 standard") were followed. Methods The terms of "Sudden deafness" and "treatment" were used as the keywords in searching articles published between 2000 and 2004 in the Chinese biomedicine literature database and Chinese journal network. Principles of evidence-based medicine were applied in reviewing the articles. Results Two hundreds and thirty- four articles were identified, including 176 between 2000 and 2002 and 58 between 2003 and 2004. Among the 176 articles published between 2000 and 2002,effects of medications were studies in 126 articles, of which only 26 (20.6%) followed the"1996 standards".Eighty-nine (70.6%) were reported based on controlled clinical trials (CCT) and 36 (28.5%) met the criteria of randomized controlled trails (RCT). Of the 58 articles published between 2003 and 2004, drug effects were evaluated in 25 articles, which were all based on the "1996 standards". However, there lacked placebo control, follow-up data or statistical analysis in these papers. Only 6 articles reported side-effects from pharmacological treatment. Conclusions While a significant number of articles on SD were published in the past 5 years, the "1996 standards" were followed only in a small number of them. The standards may not be appropriate in guiding research and need to be modified for improved guidance to SD management. Multi-center, RCTs should be a crucial part in studies on SD.

  16. Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research. (United States)

    Fatta-Kassinos, Despo; Meric, Sureyya; Nikolaou, Anastasia


    Pollution from pharmaceuticals in the aquatic environment is now recognized as an environmental concern in many countries. This has led to the creation of an extensive area of research, including among others: their chemical identification and quantification; elucidation of transformation pathways when present in wastewater-treatment plants or in environmental matrices; assessment of their potential biological effects; and development and application of advanced treatment processes for their removal and/or mineralization. Pharmaceuticals are a unique category of pollutants, because of their special characteristics, and their behavior and fate cannot be simulated with other chemical organic contaminants. Over the last decade the scientific community has embraced research in this specific field and the outcome has been immense. This was facilitated by advances in chromatographic techniques and relevant biological assays. Despite this, a number of unanswered questions exist and still there is much room for development and work towards a more solid understanding of the actual consequences of the release of pharmaceuticals in the environment. This review tries to present part of the knowledge that is currently available with regard to the occurrence of pharmaceutical residues in aquatic matrices, the progress made during the last several years on identification of such compounds down to trace levels, and of new, previously unidentified, pharmaceuticals such as illicit drugs, metabolites, and photo-products. It also tries to discuss the main recent findings in respect of the capacity of various treatment technologies to remove these contaminants and to highlight some of the adverse effects that may be related to their ubiquitous existence. Finally, socioeconomic measures that may be able to hinder the introduction of such compounds into the environment are briefly discussed.

  17. Current state of in situ subsurface remediation by activated carbon-based amendments. (United States)

    Fan, Dimin; Gilbert, Edward J; Fox, Tom


    The last decade has seen a growing interest in applying activated carbon (AC)-based amendments for in situ subsurface remediation of organic contaminants such as chlorinated solvents and petroleum hydrocarbons. This remedial technology has been promoted by several major AC-based product vendors on the market. These products involve impregnation or co-application of chemical or biological additives to facilitate various contaminant degradation processes in conjunction with contaminant adsorption. During field applications, rapid contaminant removal and limited rebound after emplacement have often been reported and considered as two major advantages for this remedial technology. Nevertheless, questions remain to be answered regarding its true effectiveness and longevity given the lack of subsequent field characterizations and evidence of the degradation process, especially biodegradation. Additional uncertainties reside in how subsurface heterogeneity may affect the design, implementation and performance monitoring of this technology. In light of these uncertainties, this review presents an independent analysis that focuses on both the scientific and practical aspects of AC-based remedial technology for in situ subsurface remediation by gathering and synthesizing the scientific knowledge and practical lessons from a broad range of contaminant removal processes involving adsorption and/or degradation. The analysis showed that the scientific soundness of combining adsorption and degradation proposed for all the AC-based products is well supported by the literature on ex situ treatment. However, the in situ effectiveness might be affected by additional factors, such as geological heterogeneity, amendment transport and distribution, and total contaminant mass, which require more thorough and quantitative evaluation. Overall, the technology may provide a viable tool in addressing major remediation challenges encountered in current practice, such as mitigation of back

  18. Current and Future Deposition of Reactive Nitrogen to United States National Parks (United States)

    Ellis, R.; Jacob, D. J.; Zhang, L.; Payer, M.; Holmes, C. D.; Schichtel, B. A.


    The concentrations of reactive nitrogen species in the atmosphere have been altered by anthropogenic activities such as fossil fuel combustion and agriculture. The United States National Parks are protected areas wherein the natural habitat is to be conserved for future generations. However, deposition of reactive nitrogen (N) to terrestrial and aquatic ecosystems can lead to changes, some of which may not be reversible. We investigate the deposition of N to U.S. National Parks using the GEOS-Chem chemical transport model with 0.5 x 0.667 degree resolution over North America. We compare the annual nitrogen deposition for each park to a critical load, above which significant harmful effects on specific ecosystem elements are likely to occur. For our base year 2006, we find 9 parks to be in exceedance of their critical load, mainly located in the east where N deposition can reach up to 25 kg N per hectare per year. Future changes in N deposition are also investigated using the IPCC Representative Concentration Pathway (RCP) emission scenarios for 2050. We use RCP8.5 as a "business-as-usual" scenario for N deposition and find that under this emission scenario, 18 parks are predicted to be in exceedance of their critical loads by the year 2050. Most of this increase in N deposition is due to increases in the emissions of ammonia. RCP4.5 was used as a more optimistic scenario but we still find 12 parks in exceedance of their critical loads. This work suggests that in order to meet N deposition critical load goals in U.S. National Parks, policy-makers should consider regulations on ammonia.

  19. Fire effects on aquatic ecosystems: an assessment of the current state of the science (United States)

    Rebecca J. Bixby,; Scott D. Cooper,; Gresswell, Bob; Lee E. Brown,; Clifford N. Dahm,; Kathleen A. Dwire,


    Fire is a prevalent feature of many landscapes and has numerous and complex effects on geological, hydrological, ecological, and economic systems. In some regions, the frequency and intensity of wildfire have increased in recent years and are projected to escalate with predicted climatic and landuse changes. In addition, prescribed burns continue to be used in many parts of the world to clear vegetation for development projects, encourage desired vegetation, and reduce fuel loads. Given the prevalence of fire on the landscape, authors of papers in this special series examine the complexities of fire as a disturbance shaping freshwater ecosystems and highlight the state of the science. These papers cover key aspects of fire effects that range from vegetation loss and recovery in watersheds to effects on hydrology and water quality with consequences for communities (from algae to fish), food webs, and ecosystem processes (e.g., organic matter subsidies, nutrient cycling) across a range of scales. The results presented in this special series of articles expand our knowledge of fire effects in different biomes, water bodies, and geographic regions, encompassing aquatic population, community, and ecosystem responses. In this overview, we summarize each paper and emphasize its contributions to knowledge on fire ecology and freshwater ecosystems. This overview concludes with a list of 7 research foci that are needed to further our knowledge of fire effects on aquatic ecosystems, including research on: 1) additional biomes and geographic regions; 2) additional habitats, including wetlands and lacustrine ecosystems; 3) different fire severities, sizes, and spatial configurations; and 4) additional response variables (e.g., ecosystem processes) 5) over long (>5 y) time scales 6) with more rigorous study designs and data analyses, and 7) consideration of the effects of fire management practices and policies on aquatic ecosystems.

  20. Physician Scientist Training in the United States: A Survey of the Current Literature. (United States)

    Kosik, R O; Tran, D T; Fan, Angela Pei-Chen; Mandell, G A; Tarng, D C; Hsu, H S; Chen, Y S; Su, T P; Wang, S J; Chiu, A W; Lee, C H; Hou, M C; Lee, F Y; Chen, W S; Chen, Q


    The declining number of physician scientists is an alarming issue. A systematic review of all existing programs described in the literature was performed, so as to highlight which programs may serve as the best models for the training of successful physician scientists. Multiple databases were searched, and 1,294 articles related to physician scientist training were identified. Preference was given to studies that looked at number of confirmed publications and/or research grants as primary outcomes. Thirteen programs were identified in nine studies. Eighty-three percent of Medical Scientist Training Program (MSTP) graduates, 77% of Clinician Investigator Training Program (CI) graduates, and only 16% of Medical Fellows Program graduates entered a career in academics. Seventy-eight percent of MSTP graduates succeeded in obtaining National Institute of Health (NIH) grants, while only 15% of Mayo Clinic National Research Service Award-T32 graduates obtained NIH grants. MSTP physician scientists who graduated in 1990 had 13.5 ± 12.5 publications, while MSTP physician scientists who graduated in 1975 had 51.2 ± 38.3 publications. Additionally, graduates from the Mayo Clinic's MD-PhD Program, the CI Program, and the NSRA Program had 18.2 ± 20.1, 26.5 ± 24.5, and 17.9 ± 26.3 publications, respectively. MSTP is a successful model for the training of physician scientists in the United States, but training at the postgraduate level also shows promising outcomes. An increase in the number of positions available for training at the postgraduate level should be considered.

  1. The current state of Pinus sylvestris L. gene pool in Karelia

    Directory of Open Access Journals (Sweden)

    А. А. Ilyinov


    Full Text Available Three native populations of P. sylvestris, ssp. lapponica (Alakurtti, Gridino, Pjaozero and six native populations of P. s., ssp. sylvestris (Voinitsa, Maslozero, Vodlozero, Zaonezshye, Kivach, Sortavala along with one artificial population – Petrozavodsk seed orchard have been studied using four nuclear microsatellite primers (Spac11.8, Spac12.5, PtTX2123, PtTX2146 to find out the peculiarities of Scotch pine intraspecific diversity in Karelia. In total, 66 alleles were found. All four loci turned out to be polymorphic in all populations. The observed heterozigocity level of all studied Karelian populations was lower than expected, which is evidence of heterozygotes deficiency in Karelian pine populations. Overall, the investigated P. sylvestris populations can be described as having a high level of the genetic variability especially compared to results obtained earlier by isozyme analyses. The Petrozavodsk seed orchard ought to be mentioned as having one of the highest levels of the genetic variability, which gives evidences in favor of good state regarding representativeness of Scotch pine gene pool here. No substantial differences in genetic structure and diversity levels have been found for ss. lapponica populations vs. ss. sylvestris ones. AMOVA analysis showed that despite the significant differences between pine populations, considering both the allele composition and the genetic diversity, the major part of the variety (90 % was allocated inside group. The investigated populations were subdivided into two clusters using UPGMA technique characterized by substantial Nei distance (DN = 0.273. The former one included the majority of Karelian pine populations (DN = 0.030–0.082 along with the Alakurtti population from Murmansk region. The latter cluster consisted ofthe most isolated «Kivach» and «Zaonezshye» populations, which had the lowest levels of genetic diversity, and the «Petrozavodsk seed orchard».

  2. Nanocarriers for the treatment of glioblastoma multiforme: Current state-of-the-art. (United States)

    Karim, Reatul; Palazzo, Claudio; Evrard, Brigitte; Piel, Geraldine


    Glioblastoma multiforme, a grade IV glioma, is the most frequently occurring and invasive primary tumor of the central nervous system, which causes about 4% of cancer-associated-deaths, making it one of the most fatal cancers. With present treatments, using state-of-the-art technologies, the median survival is about 14 months and 2 year survival rate is merely 3-5%. Hence, novel therapeutic approaches are urgently necessary. However, most drug molecules are not able to cross the blood-brain barrier, which is one of the major difficulties in glioblastoma treatment. This review describes the features of blood-brain barrier, and its anatomical changes with different stages of tumor growth. Moreover, various strategies to improve brain drug delivery i.e. tight junction opening, chemical modification of the drug, efflux transporter inhibition, convection-enhanced delivery, craniotomy-based drug delivery and drug delivery nanosystems are discussed. Nanocarriers are one of the highly potential drug transport systems that have gained huge research focus over the last few decades for site specific drug delivery, including drug delivery to the brain. Properly designed nanocolloids are capable to cross the blood-brain barrier and specifically deliver the drug in the brain tumor tissue. They can carry both hydrophilic and hydrophobic drugs, protect them from degradation, release the drug for sustained period, significantly improve the plasma circulation half-life and reduce toxic effects. Among various nanocarriers, liposomes, polymeric nanoparticles and lipid nanocapsules are the most widely studied, and are discussed in this review. For each type of nanocarrier, a general discussion describing their composition, characteristics, types and various uses is followed by their specific application to glioblastoma treatment. Moreover, some of the main challenges regarding toxicity and standardized evaluation techniques are narrated in brief.

  3. Current State Of Parties’ Reconciliation Institute In The Republic Of Kazakhstan

    Directory of Open Access Journals (Sweden)

    Ardak K. Kokeman


    Full Text Available In the modern legal system of the Republic of Kazakhstan development of the mechanism for reconciliation was worked out. The President of the Republic of Kazakhstan has repeatedly pointed out the need to implement progressive world experience of extrajudicial reconciliation. This is the idea of various forms of mediation introduction in the settlement of disputes enshrined in the Concept of Legal Policy of the Republic of Kazakhstan for the period from 2010 to 2020. At the same time there is the Law "On Mediation" of the year 2011 in the Republic of Kazakhstan, which has to create legal basis for the broad and civilized use of this procedure and to reduce the increasing burden on the courts. The analysis showed that the adoption of the Law "On Mediation" has not led to a decrease load on the courts; mediation is not widespread among the population and underdeveloped. It was also noted in the article, that in 2013, for example, the courts completed only 3% of civil cases by settlement. Authors conclude that for the serious crimes, firstly committed and not connected with the death or grievous bodily harm could be settled not only between minors, but also among other socially vulnerable people - pregnant women, mothers with dependent minor children, senior citizens. Authors note that the range of methods of conciliation is large enough. It develops, including all new mechanisms into the category of the means by which it is possible to resolve any conflict without recourse to the state Justice. Consequently, the expansion of pre-trial settlement of disputes, the introduction of a simplified form of consideration of claims would contribute to the further development of fast and affordable justice.

  4. Current state of knowledge in microbial degradation of polycyclic aromatic hydrocarbons (PAHs: a review

    Directory of Open Access Journals (Sweden)

    Debajyoti Ghosal


    PAHs. The main purpose of this review is to provide an overview of current knowledge of bacteria, halophilic archaea, fungi and algae mediated degradation/transformation of PAHs. In addition, factors affecting PAHs degradation in the environment, recent advancement in genetic, genomic, proteomic and metabolomic techniques are also highlighted with an aim to facilitate the development of a new insight into the bioremediation of PAH in the environment.

  5. Current State of Knowledge in Microbial Degradation of Polycyclic Aromatic Hydrocarbons (PAHs): A Review. (United States)

    Ghosal, Debajyoti; Ghosh, Shreya; Dutta, Tapan K; Ahn, Youngho


    purpose of this review is to provide an overview of current knowledge of bacteria, halophilic archaea, fungi and algae mediated degradation/transformation of PAHs. In addition, factors affecting PAHs degradation in the environment, recent advancement in genetic, genomic, proteomic and metabolomic techniques are also highlighted with an aim to facilitate the development of a new insight into the bioremediation of PAH in the environment.

  6. Marine biodiversity in South Africa: an evaluation of current states of knowledge.

    Directory of Open Access Journals (Sweden)

    Charles L Griffiths

    Full Text Available Continental South Africa has a coastline of some 3,650 km and an Exclusive Economic Zone (EEZ of just over 1 million km(2. Waters in the EEZ extend to a depth of 5,700 m, with more than 65% deeper than 2,000 m. Despite its status as a developing nation, South Africa has a relatively strong history of marine taxonomic research and maintains comprehensive and well-curated museum collections totaling over 291,000 records. Over 3 million locality records from more than 23,000 species have been lodged in the regional AfrOBIS (African Ocean Biogeographic Information System data center (which stores data from a wider African region. A large number of regional guides to the marine fauna and flora are also available and are listed. The currently recorded marine biota of South Africa numbers at least 12,914 species, although many taxa, particularly those of small body size, remain poorly documented. The coastal zone is relatively well sampled with some 2,500 samples of benthic invertebrate communities have been taken by grab, dredge, or trawl. Almost none of these samples, however, were collected after 1980, and over 99% of existing samples are from depths shallower than 1,000 m--indeed 83% are from less than 100 m. The abyssal zone thus remains almost completely unexplored. South Africa has a fairly large industrial fishing industry, of which the largest fisheries are the pelagic (pilchard and anchovy and demersal (hake sectors, both focused on the west and south coasts. The east coast has fewer, smaller commercial fisheries, but a high coastal population density, resulting in intense exploitation of inshore resources by recreational and subsistence fishers, and this has resulted in the overexploitation of many coastal fish and invertebrate stocks. South Africa has a small aquaculture industry rearing mussels, oysters, prawns, and abalone-the latter two in land-based facilities. Compared with many other developing countries, South Africa has a well

  7. Current State of Knowledge in Microbial Degradation of Polycyclic Aromatic Hydrocarbons (PAHs): A Review (United States)

    Ghosal, Debajyoti; Ghosh, Shreya; Dutta, Tapan K.; Ahn, Youngho


    purpose of this review is to provide an overview of current knowledge of bacteria, halophilic archaea, fungi and algae mediated degradation/transformation of PAHs. In addition, factors affecting PAHs degradation in the environment, recent advancement in genetic, genomic, proteomic and metabolomic techniques are also highlighted with an aim to facilitate the development of a new insight into the bioremediation of PAH in the environment. PMID:27630626

  8. Geothermal projects funded under the NER 300 programme - current state of development and knowledge gained (United States)

    Uihlein, Andreas; Salto Saura, Lourdes; Sigfusson, Bergur; Lichtenvort, Kerstin; Gagliardi, Filippo


    scaling up technologies and operating them at commercial scale. The knowledge sharing of the NER 300 programme should lead to better planning and faster introduction of low carbon technologies in the future. Content of the presentation The presentation will introduce the geothermal projects that have been awarded funding, including their state-of-play. Insights and knowledge gained from the projects that have entered into operation will be shown and discussed. Furthermore, the presentation will provide an overview of the NER 300 programme.

  9. Learning analytics fundaments, applications, and trends : a view of the current state of the art to enhance e-learning

    CERN Document Server


    This book provides a conceptual and empirical perspective on learning analytics, its goal being to disseminate the core concepts, research, and outcomes of this emergent field. Divided into nine chapters, it offers reviews oriented on selected topics, recent advances, and innovative applications. It presents the broad learning analytics landscape and in-depth studies on higher education, adaptive assessment, teaching and learning. In addition, it discusses valuable approaches to coping with personalization and huge data, as well as conceptual topics and specialized applications that have shaped the current state of the art. By identifying fundamentals, highlighting applications, and pointing out current trends, the book offers an essential overview of learning analytics to enhance learning achievement in diverse educational settings. As such, it represents a valuable resource for researchers, practitioners, and students interested in updating their knowledge and finding inspirations for their future work.

  10. A review of current research in light-based technologies for treatment of podiatric infectious disease states. (United States)

    Bornstein, Eric


    Recently, there has been a resurgence of interest in potential phototherapy technologies for the local treatment of bacterial and fungal infection. Currently, onychomycosis is the principle disease that is the target of these phototherapies in podiatric medicine. Some of these technologies are currently undergoing in vitro and in vivo trials approved by institutional review boards. The three light-based technologies are ultraviolet light therapy, near infrared photo-inactivation therapy, and photothermal ablative antisepsis. Each of these technologies have markedly dissimilar mechanisms of action. In this review, each technology will be discussed from the perspectives of history, photobiology, individual mechanism of action, safety, and potential clinical efficacy, with data presented from published material. This review is intended to give podiatric physicians detailed information on state-of-the-art infectious disease phototherapy.

  11. Solid-State Fault Current Limiter Development : Design and Testing Update of a 15kV SSCL Power Stack

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Ram Adapa; Mr. Dante Piccone


    ABSTRACT The Solid-State Fault Current Limiter (SSCL) is a promising technology that can be applied to utility power delivery systems to address the problem of increasing fault currents associated with load growth. As demand continues to grow, more power is added to utility system either by increasing generator capacity or by adding distributed generators, resulting in higher available fault currents, often beyond the capabilities of the present infrastructure. The SSCL is power-electronics based equipment designed to work with the present utility system to address this problem. The SSCL monitors the line current and dynamically inserts additional impedance into the line in the event of a fault being detected. The SSCL is based on a modular design and can be configured for 5kV through 69kV systems at nominal current ratings of 1000A to 4000A. Results and Findings This report provides the final test results on the development of 15kV class SSCL single phase power stack. The scope of work included the design of the modular standard building block sub-assemblies, the design and manufacture of the power stack and the testing of the power stack for the key functional tests of continuous current capability and fault current limiting action. Challenges and Objectives Solid-State Current Limiter technology impacts a wide spectrum of utility engineering and operating personnel. It addresses the problems associated with load growth both at Transmission and Distribution class networks. The design concept is pioneering in terms of developing the most efficient and compact power electronics equipment for utility use. The initial test results of the standard building blocks are promising. The independent laboratory tests of the power stack are promising. However the complete 3 phase system needs rigorous testing for performance and reliability. Applications, Values, and Use The SSCL is an intelligent power-electronics device which is modular in design and can provide current

  12. Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions. (United States)

    Grimaldi, Christine; Finco, Deborah; Fort, Madeline M; Gliddon, Daniel; Harper, Kirsty; Helms, Whitney S; Mitchell, Jane A; O'Lone, Raegan; Parish, Stanley T; Piche, Marie-Soleil; Reed, Daniel M; Reichmann, Gabriele; Ryan, Patricia C; Stebbings, Richard; Walker, Mindi


    In October 2013, the International Life Sciences Institute - Health and Environmental Sciences Institute Immunotoxicology Technical Committee (ILSI-HESI ITC) held a one-day workshop entitled, "Workshop on Cytokine Release: State-of-the-Science, Current Challenges and Future Directions". The workshop brought together scientists from pharmaceutical, academic, health authority, and contract research organizations to discuss novel approaches and current challenges for the use of in vitro cytokine release assays (CRAs) for the identification of cytokine release syndrome (CRS) potential of novel monoclonal antibody (mAb) therapeutics. Topics presented encompassed a regulatory perspective on cytokine release and assessment, case studies regarding the translatability of preclinical cytokine data to the clinic, and the latest state of the science of CRAs, including comparisons between mAb therapeutics within one platform and across several assay platforms, a novel physiological assay platform, and assay optimization approaches such as determination of FcR expression profiles and use of statistical tests. The data and approaches presented confirmed that multiple CRA platforms are in use for identification of CRS potential and that the choice of a particular CRA platform is highly dependent on the availability of resources for individual laboratories (e.g. positive and negative controls, number of human blood donors), the assay through-put required, and the mechanism-of-action of the therapeutic candidate to be tested. Workshop participants agreed that more data on the predictive performance of CRA platforms is needed, and current efforts to compare in vitro assay results with clinical cytokine assessments were discussed. In summary, many laboratories continue to focus research efforts on the improvement of the translatability of current CRA platforms as well explore novel approaches which may lead to more accurate, and potentially patient-specific, CRS prediction in the

  13. Magneto-optical study of the intermediate state in type-I superconductors: Effects of sample shape and applied current

    Energy Technology Data Exchange (ETDEWEB)

    Hoberg, Jacob Ray [Iowa State Univ., Ames, IA (United States)


    The magnetic flux structures in the intermediate state of bulk, pinning-free Type-I superconductors are studied using a high resolution magneto-optical imaging technique. Unlike most previous studies, this work focuses on the pattern formation of the coexisting normal and superconducting phases in the intermediate state. The influence of various parameters such as sample shape, structure defects (pinning) and applied current are discussed in relation to two distinct topologies: flux tubes (closed topology) and laminar (open topology). Imaging and magnetization measurements performed on samples of different shapes (cones, hemispheres and slabs), show that contrary to previous beliefs, the tubular structure is the equilibrium topology, but it is unstable toward defects and flux motion. Moreover, the application of current into a sample with the geometric barrier can replace an established laminar structure with flux tubes. At very high currents, however, there exists a laminar 'stripe pattern.' Quantitative analysis of the mean tube diameter is shown to be in good agreement with the prediction proposed by Goren and Tinkham. This is the first time that this model has been confirmed experimentally. Further research into the flux tube phase shows a direct correlation with the current loop model proposed in the 1990's by Goldstein, Jackson and Dorsey. There also appears a range of flux tube density that results in a suprafroth structure, a well-formed polygonal mesh, which behaves according to the physics of foams, following standard statistical laws such as von Neumann and Lewis. The reaction of flux structures to a fast-ramped magnetic field was also studied. This provided an alignment of the structure not normally observed at slow ramp rates.

  14. Parental Involvement and Home Environment in Music: Current and Former Students from Selected Community Music Programs in Brazil and the United States (United States)

    Barnes, Gail V.; DeFreitas, Aureo; Grego, John


    The purpose of this study was to determine whether individuals' perceptions of parental involvement and home environment in music vary with nationality (Brazil/United States) and time frame (past/current). Past and current students from selected community music programs in the United States and Brazil completed the PI-HEM (Parental Involvement and…

  15. A Comparative Analysis of the Relationship among Quality Instruction, Teacher Self-Efficacy, Student Background, and Mathematics Achievement in South Korea and the United States (United States)

    Son, Ji-Won; Han, Seong Won; Kang, Chungseo; Kwon, Oh Nam


    The purpose of this study is to compare and contrast student, teacher, and school factors that are associated with student mathematics achievement in South Korea and the United States. Using the data from the Trends in International Mathematics and Science Study (TIMSS) 2011, this study examines factors that are linked to teachers who deliver…

  16. Cosmic microwave background theory. (United States)

    Bond, J R


    A long-standing goal of theorists has been to constrain cosmological parameters that define the structure formation theory from cosmic microwave background (CMB) anisotropy experiments and large-scale structure (LSS) observations. The status and future promise of this enterprise is described. Current band-powers in -space are consistent with a DeltaT flat in frequency and broadly follow inflation-based expectations. That the levels are approximately (10(-5))2 provides strong support for the gravitational instability theory, while the Far Infrared Absolute Spectrophotometer (FIRAS) constraints on energy injection rule out cosmic explosions as a dominant source of LSS. Band-powers at 100 suggest that the universe could not have re-ionized too early. To get the LSS of Cosmic Background Explorer (COBE)-normalized fluctuations right provides encouraging support that the initial fluctuation spectrum was not far off the scale invariant form that inflation models prefer: e.g., for tilted Lambda cold dark matter sequences of fixed 13-Gyr age (with the Hubble constant H0 marginalized), ns = 1.17 +/- 0.3 for Differential Microwave Radiometer (DMR) only; 1.15 +/- 0.08 for DMR plus the SK95 experiment; 1.00 +/- 0.04 for DMR plus all smaller angle experiments; 1.00 +/- 0.05 when LSS constraints are included as well. The CMB alone currently gives weak constraints on Lambda and moderate constraints on Omegatot, but theoretical forecasts of future long duration balloon and satellite experiments are shown which predict percent-level accuracy among a large fraction of the 10+ parameters characterizing the cosmic structure formation theory, at least if it is an inflation variant.

  17. Disadvantaged family background and depression among young adults in the United States: the roles of chronic stress and self-esteem. (United States)

    Mossakowski, Krysia N


    Although several longitudinal studies have demonstrated that having a disadvantaged family background is a risk factor for subsequent symptoms of depression, few studies have examined the mediating mechanisms that explain this long-term relationship. Thus, this study uses US national longitudinal data and integrates social stress theory with the life course perspective by focusing on two mediating mechanisms-the chronic stress of poverty and self-esteem during the transition to adulthood. Results reveal that self-esteem largely mediates the inverse relationship between parental education and levels of depressive symptoms in young adulthood. However, the inverse relationship between parental occupational prestige and depressive symptoms among young adults is not mediated by self-esteem, but rather long durations of poverty across 16 years. Overall, these findings suggest that different components of family socioeconomic status can leave a lasting imprint on mental health via the self-concept and the chronic stress of poverty throughout the journey to adulthood.

  18. Estimation of standard model backgrounds to the search for electroweak production of supersymmetry in events with at least two tau leptons in the final state

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Sebastian


    This thesis presents a search for Supersymmetry in events with at least two hadronically decaying tau leptons and missing transverse energy. The analysis is focused on the electro-weak production of gaugino pairs. Electroweak production processes for SUSY particles are promising candidates for the discovery of Supersymmetry with R-parity conservation at hadron-hadron colliders. For the analysis a sample of proton-proton collisions at a center of mass energy of √(s)=8 TeV with an integrated luminosity of ∫ L dt=20.3 fb{sup -1} is used. The collisions have been recorded with the ATLAS detector at the LHC in the year 2012. In two different selections the Standard Model predictions are compared with the observations. The observation of 6 events in the first selection and 14 in the second does not deviate significantly from the Standard Model with an expectation of 11 events in the first selection and 17 in the second. These results are interpreted in a phenomenological Minimal Supersymmetric Standard Model and in simplified models. For a simplified model with a chargino-neutralino pair production scenario the parameter space for masses of the lightest neutralino up to 100 GeV and up to 350 GeV for the lightest chargino mass can be excluded. For a simplified model with chargino pair production processes the parameter space for the lightest neutralino mass up to 30-50 GeV in a range for the lightest chargino mass of 170-330 GeV can be excluded. This thesis is focused on the estimation techniques of Standard Model background processes. Different methods for the estimation of the background originating from Z-boson and top-quark decays are investigated.

  19. Characterization of Final State Interaction Strength in Plastic Scintillator by Muon-Neutrino Charged Current Charged Pion Production

    Energy Technology Data Exchange (ETDEWEB)

    Eberly, Brandon M. [Univ. of Pittsburgh, PA (United States)


    Precise knowledge of neutrino-nucleus interactions is increasingly important as neutrino oscillation measurements transition into the systematics-limited era. In addition to modifying the initial interaction, the nuclear medium can scatter and absorb the interaction by-products through final state interactions, changing the types and kinematic distributions of particles seen by the detector. Recent neutrino pion production data from MiniBooNE is inconsistent with the final state interaction strength predicted by models and theoretical calculations, and some models fit best to the MiniBooNE data only after removing final state interactions entirely. This thesis presents a measurement of dσ/dTπ and dσ/dθπ for muon-neutrino charged current charged pion production in the MINER A scintillator tracker. MINER A is a neutrino-nucleus scattering experiment installed in the few-GeV NuMI beam line at Fermilab. The analysis is limited to neutrino energies between 1.5-10 GeV. Dependence on invariant hadronic mass W is studied through two versions of the analysis that impose the limits W < 1.4 GeV and W < 1.8 GeV. The lower limit on W increases compatibility with the MiniBooNE pion data. The shapes of the differential cross sections, which depend strongly on the nature of final state interactions, are compared to Monte Carlo and theoretical predictions. It is shown that the measurements presented in this thesis favor models that contain final state interactions. Additionally, a variety of neutrino-nucleus interaction models are shown to successfully reproduce the thesis measurements, while simultaneously failing to describe the shape of the MiniBooNE data.

  20. High current density ion beam obtained by a transition to a highly focused state in extremely low-energy region. (United States)

    Hirano, Y; Kiyama, S; Fujiwara, Y; Koguchi, H; Sakakita, H


    A high current density (≈3 mA/cm(2)) hydrogen ion beam source operating in an extremely low-energy region (E(ib) ≈ 150-200 eV) has been realized by using a transition to a highly focused state, where the beam is extracted from the ion source chamber through three concave electrodes with nominal focal lengths of ≈350 mm. The transition occurs when the beam energy exceeds a threshold value between 145 and 170 eV. Low-level hysteresis is observed in the transition when E(ib) is being reduced. The radial profiles of the ion beam current density and the low temperature ion current density can be obtained separately using a Faraday cup with a grid in front. The measured profiles confirm that more than a half of the extracted beam ions reaches the target plate with a good focusing profile with a full width at half maximum of ≈3 cm. Estimation of the particle balances in beam ions, the slow ions, and the electrons indicates the possibility that the secondary electron emission from the target plate and electron impact ionization of hydrogen may play roles as particle sources in this extremely low-energy beam after the compensation of beam ion space charge.