Rigidity of complete noncompact bach-flat n-manifolds

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Chu, Yawei; Feng, Pinghua

2012-11-01

Let (Mn,g) be a complete noncompact Bach-flat n-manifold with the positive Yamabe constant and constant scalar curvature. Assume that the L2-norm of the trace-free Riemannian curvature tensor R∘m is finite. In this paper, we prove that (Mn,g) is a constant curvature space if the L-norm of R∘m is sufficiently small. Moreover, we get a gap theorem for (Mn,g) with positive scalar curvature. This can be viewed as a generalization of our earlier results of 4-dimensional Bach-flat manifolds with constant scalar curvature R≥0 [Y.W. Chu, A rigidity theorem for complete noncompact Bach-flat manifolds, J. Geom. Phys. 61 (2011) 516-521]. Furthermore, when n>9, we derive a rigidity result for R<0.

The normal conformal Cartan connection and the Bach tensor

International Nuclear Information System (INIS)

Korzynski, Mikolaj; Lewandowski, Jerzy

2003-01-01

The goal of this paper is to express the Bach tensor of a four-dimensional conformal geometry of an arbitrary signature by the Cartan normal conformal (CNC) connection. We show that the Bach tensor can be identified with the Yang-Mills current of the connection. It follows from that result that a conformal geometry whose CNC connection is reducible in an appropriate way has a degenerate Bach tensor. As an example we study the case of a CNC connection which admits a twisting covariantly constant twistor field. This class of conformal geometries of this property is known as given by the Fefferman metric tensors. We use our result to calculate the Bach tensor of an arbitrary Fefferman metric and show that it is proportional to the tensorial square of the four-fold eigenvector of the Weyl tensor. Finally, we solve the Yang-Mills equations imposed on the CNC connection for all the homogeneous Fefferman metrics. The only solution is the Nurowski-Plebanski metric

The Bach equations in spin-coefficient form

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Forbes, Hamish

2018-06-01

Conformal gravity theories are defined by field equations that determine only the conformal structure of the spacetime manifold. The Bach equations represent an early example of such a theory, we present them here in component form in terms of spin- and boost-weighted spin-coefficients using the compacted spin-coefficient formalism. These equations can be used as an efficient alternative to the standard tensor form. As a simple application we solve the Bach equations for pp-wave and static spherically symmetric spacetimes.

Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells.

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Sato, Yuki; Kato, Hiroki; Ebina-Shibuya, Risa; Itoh-Nakadai, Ari; Okuyama, Ryuhei; Igarashi, Kazuhiko

2017-03-01

Bach2 is a transcription factor which represses its target genes and plays important roles in the differentiation of B and T lymphoid cells. Bach2-deficient (KO) mice develop severe pulmonary alveolar proteinosis, which is associated with increased numbers of granulocytes and T cells. Bach2 is essential for the regulation of T cells, but its role in the regulation of granulocytes is not clear. Here, we observed increased numbers of eosinophils but not neutrophils in the bone marrow, spleen, peripheral blood, and bronchoalveolar lavage fluids of Bach2 KO mice compared with those of wild-type (WT) mice. Upon co-transplantation of the bone marrow cells from CD45.2 Bach2 KO and CD45.1/CD45.2 double-positive WT mice to irradiated WT CD45.1/CD45.2 mice, the reconstituted numbers of eosinophils were similar between Bach2 KO and WT cells. These results showed that the deficiency of Bach2 in eosinophils did not directly drive the differentiation of eosinophils. To investigate the effect of Bach2 KO CD4 + T cells upon eosinophils, we analyzed Rag2/Bach2-double deficient (dKO) mice which lack lymphocytes including CD4 + T cells. Rag2/Bach2 dKO mice did not show any increase in the numbers of eosinophils. Importantly, Bach2 KO mice showed an increase of interleukin-5 (Il-5) in the sera compared with WT mice. These results suggest that up-regulated functions of CD4 + T cells including secretion of Il-5 resulted in proliferation and/or migration to peripheral tissues of eosinophils in Bach2 KO mice. We propose that Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 in CD4 + T cells.

Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury.

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Masakazu Yamaoka

Full Text Available Free heme, a pro-oxidant released from myoglobin, is thought to contribute to the pathogenesis of rhabdomyolysis-associated acute kidney injury (RM-AKI, because renal overexpression of heme oxygenase-1 (HO-1, the rate-limiting enzyme in heme catabolism, confers protection against RM-AKI. BTB and CNC homology 1 (Bach1 is a heme-responsive transcription factor that represses HO-1. Here, we examined the changes with time in the gene expression of Bach1, HO-1, and δ-aminolevulinate synthase (ALAS1, a heme biosynthetic enzyme in the rat kidney using an RM-AKI model induced by the injection of 50% glycerol (10 mL/kg body weight into bilateral limbs. We also examined the protein expression of Bach1 in the nucleus and cytosol, and HO-1 in the rat kidney. Glycerol treatment induced significant elevation of serum creatinine kinase and aspartate aminotransferase levels followed by the marked elevation of serum blood urea nitrogen and creatinine levels, which caused serious damage to renal tubules. Following glycerol treatment, HO-1 mRNA and protein levels were significantly up-regulated, while ALAS1 mRNA expression was down-regulated, suggesting an increase in the free renal heme concentration. The Bach1 mRNA level was drastically increased 3 h after glycerol treatment, and the increased level was maintained for 12 h. Nuclear Bach1 protein levels were significantly decreased 3 h after treatment. Conversely, cytosolic Bach1 protein levels abruptly increased after 6 h. In conclusion, we demonstrate the dynamic changes in Bach1 expression in a rat model of RM-AKI. Our findings suggest that the increase in Bach1 mRNA and cytosolic Bach1 protein expression may reflect de novo Bach1 protein synthesis to compensate for the depletion of nuclear Bach1 protein caused by the induction of HO-1 by free heme.

Blindness of Johann Sebastian Bach.

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Tarkkanen, Ahti

2013-03-01

Johann Sebastian Bach (1685-1750) was one of the greatest composers of all time. Apart from performing as a brilliant organist, he composed over 1.100 works in almost every musical genre. He was known as a hardworking, deeply Christian person, who had to support his family of 20 children and many students staying at his home. At the age of 64 years, his vision started to decline. Old biographies claim that it was the result of overstressing his vision in poor illumination. By persuasion of his friends, he had his both eyes operated by a travelling British eye surgeon. A cataract couching was performed. After surgery, Bach was totally blind and unable to play an organ, compose or direct choirs and orchestras. He was confined to bed and suffering from immense pain of the eyes and the body. He died <4 months after surgery. In this paper, as the plausible diagnosis, intractable glaucoma because of pupillary block or secondary to phacoanaphylactic endophthalmitis is suggested. © 2012 The Author. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.

Stanley Fish, Chi ha paura di Wolfgang Iser?

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Laura Massari

2011-12-01

Full Text Available Presentiamo qui la traduzione del saggio di Stanley Fish, Why no one’safraid of Wolfgang Iser, pubblicato nel numero di Marzo 1981 della rivista Diacritics. L’articolo fu scritto in risposta all’intervista a Wolfgang Iser, pubblicata nel numero precedente della stessa rivista, ma prende spunto per lo più da una delle massime opere di Iser, ovvero L’atto di lettura. Una teoria della risposta estetica (Il Mulino, Bologna, 1987. In esso l’autore valuta, critica e confuta molti dei capisaldi della teoria letteraria iseriana, a partire dalla natura ontologica degli agenti coinvolti nell’atto di lettura, fino all’esame fenomenologico  dell’interpretazione, che Fish applica sia al testo letterario che alla percezione del mondo reale.

Jesu, meine Freude BWV 227 van Johann Sebastian Bach : een praedicatio sonora

NARCIS (Netherlands)

Eikelboom, A.

2007-01-01

In the oeuvre of Johann Sebastian Bach the motets take only a modest position. According to Bach's early biographers he must have written many motets, but only few have been preserved. Among these motets Jesu, meine Freude BWV 227 occupies a special position. It is the only one which combines a

Positive Feed-Bach: A Motivation Game.

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Kennedy, William G.

1984-01-01

Classroom scrip emblazoned with a picture of Johann Sebastian Bach is used to motivate junior high school students. Students are paid for cooperation and performance. Two auctions are held during the school year, at which students can spend the scrip on musical items. (CS)

USING BACH FLOWER IN HOLISTIC PSYCHOTHERAPY

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Vagner Ferreira do Nascimento

2017-05-01

Full Text Available This is a narrative review from scientific literature that aimed to describe concepts and approaches for indications of the therapeutic use of Bach flower remedies in holistic psychotherapy. The review was developed in February 2016 from books, official documents and articles indexed in Lilacs and Scielo databases. Bach flower remedies is a therapeutic method that aims to restore the balance of human being, restoring its vital energy through holistic care. Because the flower essences act on psychic and emotional dimension of individual, when employed in holistic psychotherapy can provide greater autonomy, self-care and effectiveness compared to other alternative methods. The literature indicated that flower essence therapy is a safe practice and can be used in a complementary to health care, but should be performed by qualified professionals. It has also shown to be a promising and important area for nursing professional, but it still requires greater investment in research in the area to support the practice.

Extremal Kähler metrics and Bach-Merkulov equations

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Koca, Caner

2013-08-01

In this paper, we study a coupled system of equations on oriented compact 4-manifolds which we call the Bach-Merkulov equations. These equations can be thought of as the conformally invariant version of the classical Einstein-Maxwell equations. Inspired by the work of C. LeBrun on Einstein-Maxwell equations on compact Kähler surfaces, we give a variational characterization of solutions to Bach-Merkulov equations as critical points of the Weyl functional. We also show that extremal Kähler metrics are solutions to these equations, although, contrary to the Einstein-Maxwell analogue, they are not necessarily minimizers of the Weyl functional. We illustrate this phenomenon by studying the Calabi action on Hirzebruch surfaces.

Poeetilise utoopia meister Aino Bach

Index Scriptorium Estoniae

2003-01-01

28. III-11. V Adamson-Ericu muuseumis graafik Aino Bachi loomingu ülevaatenäitus. Võrdluseks on eksponeeritud Eduard Wiiralti ja Kaarel Liimandi tööd. Näha võib Mark Soosaare filmi A. Bachist "Liblikapüüdja" (1978). Kuraator Anne Lõugas, kujundaja Virge Jõekalda. Kai Tuviku juhendamisel muuseumitunnid "Kuidas joonistada inimest?". 1. IV seminaril "Naiskunstnik ja tema aeg. Aino Bach" esinejad, ettekanded

Heme-dependent up-regulation of the α-globin gene expression by transcriptional repressor Bach1 in erythroid cells

International Nuclear Information System (INIS)

Tahara, Tsuyoshi; Sun Jiying; Igarashi, Kazuhiko; Taketani, Shigeru

2004-01-01

The transcriptional factor Bach1 forms a heterodimer with small Maf family, and functions as a repressor of the Maf recognition element (MARE) in vivo. To investigate the involvement of Bach1 in the heme-dependent regulation of the expression of the α-globin gene, human erythroleukemia K562 cells were cultured with succinylacetone (SA), a heme biosynthetic inhibitor, and the level of α-globin mRNA was examined. A decrease of α-globin mRNA was observed in SA-treated cells, which was restored by the addition of hemin. The heme-dependent expression of α-globin occurred at the transcriptional level since the expression of human α-globin gene promoter-reporter gene containing hypersensitive site-40 (HS-40) was decreased when K562 cells were cultured with SA. Hemin treatment restored the decrease of the promoter activity by SA. The regulation of the HS-40 activity by heme was dependent on the NF-E2/AP-1 (NA) site, which is similar to MARE. The NA site-binding activity of Bach1 in K562 increased upon SA-treatment, and the increase was diminished by the addition of hemin. The transient expression of Bach1 and mutated Bach1 lacking CP motifs suppressed the HS-40 activity, and cancellation of the repressor activity by hemin was observed when wild-type Bach1 was expressed. The expression of NF-E2 strengthened the restoration of the Bach1-effect by hemin. Interestingly, nuclear localization of Bach1 increased when cells were treated with SA, while hemin induced the nuclear export of Bach1. These results indicated that heme plays an important role in the induction of α-globin gene expression through disrupting the interaction of Bach1 and the NA site in HS-40 enhancer in erythroid cells

[Jan Fryderyk Wolfgang's autobiography (1850) in the light of hand-written and printed sources].

Science.gov (United States)

Kuźnicka, B

2001-01-01

The archival collection of the Lithuanian Academy of Sciences in Vilnius (Wilno) contains many manuscripts relating to the scientific work of Jan Fryderyk Wolfgang (1776-1859), professor of pharmacy and pharmacology of the Wilno University in the years 1807-1831, the founder and main figure in the Wilno pharmacognostic school, a botanist with substantial achievements in wide-ranging research on the flora of the Wilno region, as well as a historian of pharmacy. The most interesting of the manuscripts include Wolfgang's Autobiografia [Autobiography], written in 1850, and a list of his publications covering a total of 57 items (including some that have hitherto remained unknown), a work entitled Historya Farmakologii i Farmacyi [History of pharmacology and pharmacy], and a particularly valuable manuscript (666 + 12 sheets) entitled Farmakologiia [Pharmacology]. Worth mentioning are also two catalogues of books from Wolfgang's library: one compiled by Wolfgang himself (37 sheets) and the other by Adam Ferdynand Adamowicz. The content of the autobiography manuscript is contained on five sheets. The author of the present article analyzes the document, comparing the information contained in it with the biographies of J. F. Wolfgang that hhave been published so far (these being primarily the biography by Dominik Cezary ChodYko, published in 1863, and that by Witold W3odzimierz G3owacki of 1960). The text of the autobiography is quoted in full, together with numerous comments. The analysis of the manuscript as well as the biographical data contained in the above-mentioned biographies indicate that Wolfgang had great achievements as a scientist (in both research and organizational work), as a champion of public causes and as an educator of a generation of botanists-pharmacognostics. It also transpires from the autobiography, as well as from the research by historians, that he was a very good and trustful person, who readily granted access to his research to his collaborators

Respek vir die liturgiese teks: J. Calvyn en J.S. Bach | Schulze | Acta ...

African Journals Online (AJOL)

Despite obvious differences in terms of historical and theological aspects between Calvin and Bach, both share a respect for the priority of the Biblical text in worship.The anomaly between Calvin's engagement in the versification of the Psalter and Bach's preference for the literal (rather than a versified) use of the Biblical ...

Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells

OpenAIRE

Jang, Eunkyeong; Lee, Hye Rim; Lee, Geon Hee; Oh, Ah-Reum; Cha, Ji-Young; Igarashi, Kazuhiko; Youn, Jeehee

2017-01-01

The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4+ T cells, Bach2 overexpression counteracted T cell receptor/CD28- or PMA/ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2...

Reader-Response Theory: A Path Towards Wolfgang Iser (La teoría de la recepción: una ruta hacia Wolfgang Iser

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Alejandra Giangiulio Lobo

2015-09-01

Full Text Available Se estudia la teoría de la recepción a partir de diferentes autores y críticos literarios, para caracterizar los distintos tipos de lectores, según cada aproximación y los procesos de lectura y creación de significado. El ensayo se centra en el enfoque fenomenológico de Wolfgang Iser sobre la recepción del lector, la generación de significado y los tipos de lectores. Reader-response theory is studied from the perspective of different authors and literary critics to characterize the different types of readers, according to each approach, the reading process and the creation of meaning. The essay centers on Wolfgang Iser’s phenomenological approach to reader response, creation of meaning and types of readers.

Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K.

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Zhu, Zhengwei; Yang, Chao; Wen, Leilei; Liu, Lu; Zuo, Xianbo; Zhou, Fusheng; Gao, Jinping; Zheng, Xiaodong; Shi, Yinjuan; Zhu, Caihong; Liang, Bo; Yin, Xianyong; Wang, Wenjun; Cheng, Hui; Shen, Songke; Tang, Xianfa; Tang, Huayang; Sun, Liangdan; Zhang, Anping; Yang, Sen; Cui, Yong; Zhang, Xuejun; Sheng, Yujun

2018-04-01

This study was aimed to explore the effect of Bach2 on B cells in systemic lupus erythematosus (SLE), as well as the underlying mechanisms. Expression of Bach2, phosphorylated-Bach2 (p-Bach2), Akt, p-Akt and BCR-ABL (p210) in B cells isolated from SLE patients and the healthy persons were assessed by Western blot. Immunofluorescence staining was performed to assess the localization of Bach2 in B cells. Enzyme-linked immunosorbent assay (ELISA) was employed to detect IgG produced by B cells. Cell counting kit-8 (CCK-8) and Annexin-V FITC/PI double staining assay were adopted to evaluate cell proliferation and apoptosis in B cells, respectively. Compared to the healthy controls, Bach2, p-Akt and p210 were significantly decreased, while nuclear translocation of Bach2, IgG, CD40 and CD86 obviously up-regulated in B cells from SLE patients. Bach2 significantly inhibited the proliferation, promoted apoptosis of B cells from SLE patients, whereas BCR-ABL dramatically reversed cell changes induced by Bach2. Besides, BCR-ABL also inhibited nuclear translocation of Bach2 in B cells from SLE patients. Further, LY294002 treatment had no effect on decreased expression of Bach2 induced by BCR-ABL, but significantly eliminated BCR-ABL-induced phosphorylation of Bach2 and restored reduced nuclear translocation of Bach2 induced by BCR-ABL in B cells from SLE. Bach2 may play a suppressive role in B cells from SLE, and BCR-ABL may inhibit the nuclear translocation of Bach2 via serine phosphorylation through the PI3K pathway. Copyright © 2018 Elsevier Inc. All rights reserved.

Wolfgang Pauli - a portrait. History of science; Wolfgang Pauli - ein Portrait. Wissenschaftsgeschichte

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Fischer, E.P.

2008-07-01

Wolfgang Pauli (1900-1958) is named by his colleagues in the same breath with Isaac Newton and Albert Einstein, who named Pauli his ''mental son''. The history of science had neglected Pauli for a long time. The reason for this may be found in Pauli's attempts to capture the role of the unconscious in physics and the meaning of dreams in the creation of scientific pictures of the world. For Pauli a scientific method consisted in activating the unconscious and hoping that it would start up that specific type of ''painting viewing'' from which the terms can arise by which we express our understanding.

Wearing red for signaling: the heme-bach axis in heme metabolism, oxidative stress response and iron immunology.

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Igarashi, Kazuhiko; Watanabe-Matsui, Miki

2014-04-01

The connection between gene regulation and metabolism is an old issue that warrants revisiting in order to understand both normal as well as pathogenic processes in higher eukaryotes. Metabolites affect the gene expression by either binding to transcription factors or serving as donors for post-translational modification, such as that involving acetylation and methylation. The focus of this review is heme, a prosthetic group of proteins that includes hemoglobin and cytochromes. Heme has been shown to bind to several transcription factors, including Bach1 and Bach2, in higher eukaryotes. Heme inhibits the transcriptional repressor activity of Bach1, resulting in the derepression of its target genes, such as globin in erythroid cells and heme oxygenase-1 in diverse cell types. Since Bach2 is important for class switch recombination and somatic hypermutation of immunoglobulin genes as well as regulatory and effector T cell differentiation and the macrophage function, the heme-Bach2 axis may regulate the immune response as a signaling cascade. We discuss future issues regarding the topic of the iron/heme-gene regulation network based on current understanding of the heme-Bach axis, including the concept of "iron immunology" as the synthesis of the iron metabolism and the immune response.

Instructional Practices: Teaching Speech Composition with J. S. Bach.

Science.gov (United States)

Merriam, Allen H.

1979-01-01

Describes the structural similarities inherent in musical and linguistic compositions and how they reflect basic human impulses and principles of effective composition. Uses Bach's "Passacaglia" to illustrate the characteristics of good composition. (JMF)

Bach: Máxima expresión de genes musicales.

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Alfredo Jácome Roca

2001-04-01

Full Text Available

El padre de la música moderna, Juan Sebastián Bach, inauguró el milenio con explosiones armoniosas en todo el planeta, al conmemorarse 250 años de la finalización de su ciclo vital.

Como ya lo hemos indicado, la presidencia de la Academia ha querido intercalar las sesiones ordinarias con otras de tipo cultural y aprovechó este importante aniversario para hacer su contribución, al igual que lo hicieron otras importantes instituciones del país.

Por esta razón, el académico Roso Alfredo Cala Hederich nos obsequió con una agradable velada de antología, en la cual combinó la audición de trozos musicales que en su sentir representan lo mejor de la música del genio alemán (en ocasiones sirviendo de “melopea” o música de fondo para su presentación oral, con extraordinarios videos de paisajes y edificios por donde transcurrió la vida de uno de los tres más grandes compositores mundiales, junto con Beethoven y Mozart posteriormente.

Bach fue la máxima expresión musical de una familia de muchos miembros cuyo oficio artesanal fue tocar, enseñar, crear y perfeccionar la música, que fue exitosa “in crescendo” a partir del primer Bach, llegó a su clímax con J.Sebastián y fue paulatinamente decayendo hasta llegar a la buena calidad, mas no extraordinaria. Bach, consciente de la importancia de su familia en ese arte (el que además representaba el “modus vivendi” de todos ellos, escribió una crónica de 53 familiares, todos de sexo masculino, con información sobre su actividad musical, acompañada de un árbol genealógico que infortunadamente se extravió...

The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.

Science.gov (United States)

Warnatz, Hans-Jörg; Schmidt, Dominic; Manke, Thomas; Piccini, Ilaria; Sultan, Marc; Borodina, Tatiana; Balzereit, Daniela; Wruck, Wasco; Soldatov, Alexey; Vingron, Martin; Lehrach, Hans; Yaspo, Marie-Laure

2011-07-01

The regulation of gene expression in response to environmental signals and metabolic imbalances is a key step in maintaining cellular homeostasis. BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAF recognition elements, resulting in increased expression of antioxidant response genes. To systematically address the gene regulatory networks involving BACH1, we combined chromatin immunoprecipitation sequencing analysis of BACH1 target genes in HEK 293 cells with knockdown of BACH1 using three independent types of small interfering RNAs followed by transcriptome profiling using microarrays. The 59 BACH1 target genes identified by chromatin immunoprecipitation sequencing were found highly enriched in genes showing expression changes after BACH1 knockdown, demonstrating the impact of BACH1 repression on transcription. In addition to known and new BACH1 targets involved in heme degradation (HMOX1, FTL, FTH1, ME1, and SLC48A1) and redox regulation (GCLC, GCLM, and SLC7A11), we also discovered BACH1 target genes affecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, and MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, and vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis.

Microfilming of the Bach Manuscripts in the Staatsbibliothek Berlin.

Science.gov (United States)

Penzold, Leonhard

1998-01-01

Describes a microfilming project to preserve music manuscripts of Johann Sebastian Bach at the Staatsbibliothek Berlin (Germany), highlighting project goals, problems and peculiarities encountered filming the collection, color micrography, and black-and-white filming. (PEN)

The Bach-Lanczos Lagrangian in matrix relativity

International Nuclear Information System (INIS)

Maluf, J.W.

1987-01-01

The author examines the generalisation of the Bach-Lanczos Lagrangian in matrix relativity where it is no longer a topological invariant, and find that for certain structures of the matrix affine connection a Yang-Mills type Lagrangian is obtained. Thus the possibility is considered of interpreting non-Abelian gauge fields as arising from an otherwise topological invariant. (author)

Anneli Remme soovitab : Ajaloo ilu - Johann Sebastian Bach / Anneli Remme

Index Scriptorium Estoniae

Remme, Anneli, 1968-

2005-01-01

Agentuuri Corelli Music ja Eesti Klavessiinisõprade Tsunfti korraldatavast klavessiinikontsertide sarjast "Ajaloo ilu - Johann Sebastian Bach" (avakontserdid 17. sept. Kadrioru lossis, 18. sept. Pärnu Eliisabeti kirikus)

The Death of Wolfgang Amadeus Mozart: An Epidemiologic Perspective

NARCIS (Netherlands)

Zegers, Richard H. C.; Weigl, Andreas; Steptoe, Andrew

2009-01-01

The early death of the composer Wolfgang Amadeus Mozart on 5 December 1791 has fascinated the world for more than 2 centuries. It has been suggested that his final illness was caused by poisoning, renal failure, Henoch-Schonlein purpura, trichinosis, and many other conditions. The official daily

Pärt: Collage sur B-A-C-H für Kammerorschester / Hans-Christian Dadelsen

Index Scriptorium Estoniae

Dadelsen, Hans-Christian

1993-01-01

Uuest heliplaadist "Pärt: Collage sur B-A-C-H für Kammerorschester, Summa (1991) für Streichorchester, Fratres, Sinfonie Nr. 2, Festina lente, Wenn Bach Bienen gezüchtet hätte, Credo für Klavier, Chor und Orchester. Philharmonia Orchestra and Chorus, Neeme Järvi". Chandos/Koch CD 9134 (WD: 63'02")

Alanine transaminase (ALT) blood test

Science.gov (United States)

... gov/ency/article/003473.htm Alanine transaminase (ALT) blood test To use the sharing features on this page, please enable JavaScript. The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in ...

Pärt, Arvo: "Summa". Collage sur BACH. Fratres / Patric Wiklacz

Index Scriptorium Estoniae

Wiklacz, Patric

1997-01-01

Uuest heliplaadist "Pärt, Arvo: "Summa". Collage sur BACH. Fratres. Cantus in Memoriam Benjamin Britten. Summa. Festina Lente. Tabula rasa. Tapiola Sinfonietta / Jean-Jacques Kantorow". BIS-CD-834. 62:30 DDD

BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1.

Science.gov (United States)

Harusato, Akihito; Naito, Yuji; Takagi, Tomohisa; Uchiyama, Kazuhiko; Mizushima, Katsura; Hirai, Yasuko; Higashimura, Yasuki; Katada, Kazuhiro; Handa, Osamu; Ishikawa, Takeshi; Yagi, Nobuaki; Kokura, Satoshi; Ichikawa, Hiroshi; Muto, Akihiko; Igarashi, Kazuhiko; Yoshikawa, Toshikazu

2013-01-01

BTB and CNC homolog 1 (Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1), which plays an important role in the protection of cells and tissues against acute and chronic inflammation. However, the role of Bach1 in the gastrointestinal mucosal defense system remains little understood. HO-1 supports the suppression of experimental colitis and localizes mainly in macrophages in colonic mucosa. This study was undertaken to elucidate the Bach1/HO-1 system's effects on the pathogenesis of experimental colitis. This study used C57BL/6 (wild-type) and homozygous Bach1-deficient C57BL/6 mice in which colonic damage was induced by the administration of an enema of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Subsequently, they were evaluated macroscopically, histologically, and biochemically. Peritoneal macrophages from the respective mice were isolated and analyzed. Then, wild-type mice were injected with peritoneal macrophages from the respective mice. Acute colitis was induced similarly. TNBS-induced colitis was inhibited in Bach1-deficient mice. TNBS administration increased the expression of HO-1 messenger RNA and protein in colonic mucosa in Bach1-deficient mice. The expression of HO-1 mainly localized in F4/80-immunopositive and CD11b-immunopositive macrophages. Isolated peritoneal macrophages from Bach1-deficient mice highly expressed HO-1 and also manifested M2 macrophage markers, such as Arginase-1, Fizz-1, Ym1, and MRC1. Furthermore, TNBS-induced colitis was inhibited by the transfer of Bach1-deficient macrophages into wild-type mice. Deficiency of Bach1 ameliorated TNBS-induced colitis. Bach1-deficient macrophages played a key role in protection against colitis. Targeting of this mechanism is applicable to cell therapy for human inflammatory bowel disease.

Johann Wolfgang von Goethe: arte e natureza, poesia e ciência Johann Wolfgang von Goethe: art and nature, poetry and science

Directory of Open Access Journals (Sweden)

Izabela Maria Furtado Kestler

2006-10-01

Full Text Available Este artigo apresenta a obra científica do poeta alemão Johann Wolfgang von Goethe (1749-1832, a qual engloba os campos da anatomia humana e animal, ótica, geologia, mineralogia, química, botânica, morfologia e meteorologia. Goethe considerava que na natureza e na arte vigiam as mesmas leis, conceituadas por ele como leis da polaridade e da intensificação. Sua obra poética só pode ser avaliada e interpretada à luz de sua visão da harmonia entre homem e natureza, assim como da complementaridade entre espírito e matéria.The scientific work of German poet Johann Wolfgang von Goethe (1749-1832 encompassed the fields of human and animal anatomy, optics, geology, mineralogy, chemistry, botany, morphology, and meteorology. Goethe believed that nature and art were governed by the same laws, concepts he designated as the laws of "polarity" and "intensification." His poetic works can only be evaluated and interpreted if approached from his understanding of harmony between man and nature, and his view of the complementary relations between spirit and matter.

LEP Celebration : Groupe de Jazz "Wolfgang & The Werewolves"

CERN Multimedia

CERN. Geneva

2000-01-01

At 14:00: Groupe de Jazz "Wolfgang & The Werewolves" . The official programme begins at 15:00 with an introduction from the Director General, and Professor Martinus Veltman will give the keynote speech. Heads of national delegations represented at ministerial level will then make their speeches, following which a commemorative plaque will be unveiled. A specially commissioned ballet by Maurice Béjart will bring the ceremony to a close.

"Lihtsate eestlaste ebausukombed" ja Johann Wolfgang Boecleri tagasitulek. Lisandusi kiriku, kirjanduse ja kommete ajaloole / Aivar Põldvere

Index Scriptorium Estoniae

Põldvere, Aivar

2008-01-01

Johann Wolfgang Boeckleri (Heinrich Gösekeni väimehe) värvikast elukäigust. Kas Johann Heinrich Boeckler võis olla tema onu? "Lihtsate eestlaste ebausukommete" retseptsioonist. Eeestlaste kommetest ja usust. J. W. Boeckleri sidemetest Thomas Hiärnega. Boeckleri ilmumata jäänud eestlaste ajalugu käsitlenud raamatust. Boeckleri oletatavast spioonikarjäärist, tema kõikumisest luterluse ja katoliikluse vahel. Lisa : Johann Wolfgang Boeckleri bibliograafia

Wolfgang Pauli at the 6th meeting of the Nobel Prize laureates

CERN Multimedia

Franz Thorbecke, Lindau

1956-01-01

From left to right : ?, Max Born, Paul Adrien Maurice Dirac, Adolf Friedrich Johann Butenandt, ?, Otto Hahn, Wolfgang Pauli, Franca Pauli, Sir Chandrasekhara Venkata Raman, Isidor Isaac Rabi, and Leopold Ruzicka

Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice.

Science.gov (United States)

Ohta, Ryo; Tanaka, Nobuhiro; Nakanishi, Kazuyoshi; Kamei, Naosuke; Nakamae, Toshio; Izumi, Bunichiro; Fujioka, Yuki; Ochi, Mitsuo

2012-09-01

Intervertebral disc degeneration is considered to be a major feature of low back pain. Furthermore, oxidative stress has been shown to be an important factor in degenerative diseases such as osteoarthritis and is considered a cause of intervertebral disc degeneration. The purpose of this study was to clarify the correlation between oxidative stress and intervertebral disc degeneration using Broad complex-Tramtrack-Bric-a-brac and cap'n'collar homology 1 deficient (Bach 1-/-) mice which highly express heme oxygenase-1 (HO-1). HO-1 protects cells from oxidative stress. Caudal discs of 12-week-old and 1-year-old mice were evaluated as age-related models. Each group and period, 5 mice (a total of 20 mice, a total of 20 discs) were evaluated as age-related model. C9-C10 caudal discs in 12-week-old Bach 1-/- and wild-type mice were punctured using a 29-gauge needle as annulus puncture model. Each group and period, 5 mice (a total of 60 mice, a total of 60 discs) were evaluated. The progress of disc degeneration was evaluated at pre-puncture, 1, 2, 4, 8 and 12 weeks post-puncture. Radiographic, histologic and immunohistologic analysis were performed to compare between Bach 1-/- and wild-type mice. In the age-related model, there were no significant differences between Bach 1-/- and wild-type mice radiologically and histologically. However, in the annulus puncture model, histological scoring revealed significant difference at 8 and 12 weeks post-puncture. The number of HO-1 positive cells was significantly greater in Bach 1-/- mice at every period. The apoptosis rate was significantly lower at 1 and 2 weeks post-puncture in Bach 1-/- mice. Oxidative stress prevention may avoid the degenerative process of the intervertebral disc after puncture, reducing the number of apoptosis cells. High HO-1 expression may also inhibit oxidative stress and delay the process of intervertebral disc degeneration.

Sasakian manifolds with purely transversal Bach tensor

Science.gov (United States)

Ghosh, Amalendu; Sharma, Ramesh

2017-10-01

We show that a (2n + 1)-dimensional Sasakian manifold (M, g) with a purely transversal Bach tensor has constant scalar curvature ≥2 n (2 n +1 ) , equality holding if and only if (M, g) is Einstein. For dimension 3, M is locally isometric to the unit sphere S3. For dimension 5, if in addition (M, g) is complete, then it has positive Ricci curvature and is compact with finite fundamental group π1(M).

RESPEK VIR DIE LITURGIESE TEKS: J. CALVYN EN J.S. BACH

African Journals Online (AJOL)

admin

Calvin and Bach, both share a respect for the priority of the Biblical text in worship. The anomaly ...... spirits” in the St. John Passion. ..... P.E. Bernoulli & F. Furler (Hrsg.), Der Genfer Psalter (Zürich: Theologischer Verlag .... London: Collins.

Fra Bach til Beatles på tre måneder!

DEFF Research Database (Denmark)

Bonde, Anders

2006-01-01

Fra Bach til Beatles på tre måneder! Didaktiske overvejelser og erfaringer på baggrund af nyt et-semesters oversigtskursus Anders Bonde Fra og med september 2005 har man på musikuddannelsen ved Aalborg Universitet, som led i implementeringen af en ny tofaglig bachelorstruktur, udviklet et nyt...

The Performance of Bach: Study of Rhythmic Timing by Skilled Musicians.

Science.gov (United States)

Johnson, Christopher M.

1999-01-01

Analyzes 15 performances of "Bach's Suite Number 3 for Violoncello solo, Bourree Number 1" and determines what patterns of rhythmic variation (rubato) were used by soloists. Indicates that the soloists demonstrated four identifiable and similar trends in the performances. (CMK)

Spherically Symmetric Solutions of the Einstein-Bach Equations and a Consistent Spin-2 Field Theory

International Nuclear Information System (INIS)

Janda, A.

2006-01-01

We briefly present a relationship between General Relativity coupled to certain spin-0 and spin-2 field theories and higher derivatives metric theories of gravity. In a special case, described by the Einstein-Bach equations, the spin-0 field drops out from the theory and we obtain a consistent spin-two field theory interacting gravitationally, which overcomes a well known inconsistency of the theory for a linear spin-two field coupled to the Einstein's gravity. Then we discuss basic properties of static spherically symmetric solutions of the Einstein-Bach equations. (author)

J. S. Bach: Técnica de composición como explicatio textus

Directory of Open Access Journals (Sweden)

González Valle, José V.

2002-12-01

Full Text Available During the XVII to XVIII centuries, musical theorists, especially in Protestant circles compiled, classified and published diverse constructive procedures (figures used by renaissance composers and their immediate precursors in order to express sub specie musicae the meaning of texts. In this way, composition techniques became "idiomatical". J. S. Bach's contribution in this field has been investigated and acknowledged by musicologists throughout history. For some time now, evangelical theology has been taking an interest in that particular aspect of Bach's music, as it is obvious that in order to find an explanation for texts both devout and biblical it is often useful to analyse artistic expressions of the said texts, given that, going down that path theology will learn to understand and listen to them in a new light. That is where music, more so than other art forms, acquires special importance.Durante los siglos XVII-XVIII, los teóricos de música, especialmente en ambientes protestantes, recogen, sistematizan y dan a conocer diversos procedimientos constructivos (figuras usados por los compositores renacentistas e inmediatamente posteriores para expresar sub specie musicae el contenido del texto. De este modo, la técnica de composición musical se va "idiomatizando". La aportación de J. S. Bach, en este sentido, ha sido estudiada y reconocida por la musicología histórica. Hace un tiempo, también la teología evangélica ha comenzado a interesarse en este aspecto de la música de Bach, pues parece claro, que la explicación de los textos bíblicos o devocionales puede tener éxito por medio del trabajo artístico sobre dichos textos, ya que, por este camino, la teología aprende a oírlos y entenderlos de un modo nuevo. Es aquí donde la música, mucho más que el resto de las artes, adquiere una especial importancia.

IV Bach conference on radiation chemistry. Abstracts of reports

International Nuclear Information System (INIS)

2005-01-01

IV Bach conference on radiation chemistry was conducted in the framework of the conference Physico-chemical foundations of new technologies of XXI century. Problems of radiolysis of modern polymeric materials, post-irradiation examination of different organic and inorganic compounds treated with ionizing radiation, equipment used for these examinations, application of data obtained in these researches were represented in reports [ru

Wolfgang Pauli - a portrait. History of science

International Nuclear Information System (INIS)

Fischer, E.P.

2008-01-01

Wolfgang Pauli (1900-1958) is named by his colleagues in the same breath with Isaac Newton and Albert Einstein, who named Pauli his ''mental son''. The history of science had neglected Pauli for a long time. The reason for this may be found in Pauli's attempts to capture the role of the unconscious in physics and the meaning of dreams in the creation of scientific pictures of the world. For Pauli a scientific method consisted in activating the unconscious and hoping that it would start up that specific type of ''painting viewing'' from which the terms can arise by which we express our understanding

[Drugs for young Mozart. Medical treatment of Wolfgang as a child by his father Leopold Mozart].

Science.gov (United States)

Bankl, H C; Reiter, C; Bankl, H

2001-12-17

Leopold Mozart (1719-1787), father of Wolfgang Amadé, had profound medical knowledge and was a passionate medical dilettante. As long as the young Mozart lived with his father and travelled on his concert tours with him, Leopold cared for his son in medical matters. Doctors were only consulted occasionally. In the extensive correspondence of Mozart's father drugs and treatments used for Wolfgang Amadé are reported in detail. This represents a reliable description of the pharmacological therapies of the late 18th century. The mentioned drugs are, as far as possible, viewed from todays medical perspective.

Preventive use of Bach flower Rescue Remedy in the control of risk factors for cardiovascular disease in rats.

Science.gov (United States)

Resende, Margarida Maria de Carvalho; Costa, Francisco Eduardo de Carvalho; Gardona, Rodrigo Galvão Bueno; Araújo, Rochilan Godinho; Mundim, Fiorita Gonzales Lopes; Costa, Maria José de Carvalho

2014-08-01

To evaluate the effect of Bach flower Rescue Remedy on the control of risk factors for cardiovascular disease in rats. A randomized longitudinal experimental study. Eighteen Wistar rats were randomly divided into three groups of six animals each and orogastrically dosed with either 200 μl of water (group A, control), or 100 μl of water and 100 μl of Bach flower remedy (group B), or 200 μl of Bach flower remedy (group C) every 2 days, for 20 days. All animals were fed standard rat chow and water ad libitum. Urine volume, body weight, feces weight, and food intake were measured every 2 days. On day 20, tests of glycemia, hyperuricemia, triglycerides, high-density lipoprotein (HDL) cholesterol, and total cholesterol were performed, and the anatomy and histopathology of the heart, liver and kidneys were evaluated. Data were analyzed using Tukey's test at a significance level of 5%. No significant differences were found in food intake, feces weight, urine volume and uric acid levels between groups. Group C had a significantly lower body weight gain than group A and lower glycemia compared with groups A and B. Groups B and C had significantly higher HDL-cholesterol and lower triglycerides than controls. Animals had mild hepatic steatosis, but no cardiac or renal damage was observed in the three groups. Bach flower Rescue Remedy was effective in controlling glycemia, triglycerides, and HDL-cholesterol and may serve as a strategy for reducing risk factors for cardiovascular disease in rats. This study provides some preliminary "proof of concept" data that Bach Rescue Remedy may exert some biological effects. Copyright © 2014 Elsevier Ltd. All rights reserved.

Wolfgang Klafki's Concept of "Didaktik" and Its Reception in Russia

Science.gov (United States)

Meyer, Meinert A.; Rakhkochkine, Anatoli

2018-01-01

We take the reception of Wolfgang Klafki's didactics in Russia as our example for the difficult relations between knowledge transfer and knowledge transformation. We start with a description, analysis and evaluation of Klafki's two didactical models, categorical didactics and critical-constructive didactics, and then describe and evaluate their…

Wolfgang Iser, Lo spettro dell'interpretazione Wolfgang Iser, Lo spettro dell'interpretazione Wolfgang Iser, The Range of Interpretation

Directory of Open Access Journals (Sweden)

Laura Lucia Rossi

2009-06-01

Full Text Available Proponiamo la traduzione di due capitoli di The Range of Interpretation di Wolfgang Iser, in cui il teorico tedesco svolge un'analisi dell'interpretazione con particolare attenzione alle tre modalità operative paradigmatiche del circolo ermeneutico, del loop ricorsivo e del traveling differential, in un'ottica volta a sottolineare il valore di dispositivo antropologico dell'interpretazione, attraverso una sempre più pregnante istanza costruttivista che conduce, infine, ad una serie di conclusioni etiche.Мы предлагаем перевод двух глав из The Range of Interpretation Вольфганга Изера, в которых немецкий теоретик проводит анализ интерпретации, с особым вниманием на три оперативные методики: герменевтический круг, повторяющийся loop и traveling differential, с намерением подчеркнуть значение интерпретации как антропологической установки с помощью все более значимого и настоятельного конструктивизма, который приводит наконец к некоторым этическим заключениям.We propose here the translation of two chapters from The Range of Interpretation by Wolfgang Iser, in which the German theorist provides an analysis of interpretation, with specific attention to the three operational modes of the hermeneutic circle, of the recursive loop and of the traveling differential in a perspective meant to highlight the role of interpretation as anthropological device, through an increasingly pregnant constructivist disposition leading to, in the end, to a series of ethical conclusions.

Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

Directory of Open Access Journals (Sweden)

Erendira Rojas-Ortega

2018-05-01

Full Text Available Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion, followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the members of the gene pair lacks the apparent ancestral physiological role. This paper analyzes structural organization and pyridoxal phosphate (PLP binding properties of ScAlt1 and ScAlt2 indicating functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine metabolism. It was found that ScAlt1 and ScAlt2 are dimeric enzymes harboring 67% identity and intact conservation of the catalytic residues, with very similar structures. However, tertiary structure analysis indicated that ScAlt2 has a more open conformation than that of ScAlt1 so that under physiological conditions, while PLP interaction with ScAlt1 allows the formation of two tautomeric PLP isomers (enolimine and ketoenamine ScAlt2 preferentially forms the ketoenamine PLP tautomer, indicating a modified polarity of the active sites which affect the interaction of PLP with these proteins, that could result in lack of alanine transaminase activity in ScAlt2. The fact that ScAlt2 forms a catalytically active Schiff base with PLP and its position in an independent clade in “sensu strictu” yeasts suggests this protein has a yet undiscovered physiological function.

Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has Been Driven by Diversification of Pyridoxal Phosphate Interactions

Science.gov (United States)

Rojas-Ortega, Erendira; Aguirre-López, Beatriz; Reyes-Vivas, Horacio; González-Andrade, Martín; Campero-Basaldúa, Jose C.; Pardo, Juan P.; González, Alicia

2018-01-01

Saccharomyces cerevisiae arose from an interspecies hybridization (allopolyploidiza-tion), followed by Whole Genome Duplication. Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, constituting an example in which one of the members of the gene pair lacks the apparent ancestral physiological role. This paper analyzes structural organization and pyridoxal phosphate (PLP) binding properties of ScAlt1 and ScAlt2 indicating functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine metabolism. It was found that ScAlt1 and ScAlt2 are dimeric enzymes harboring 67% identity and intact conservation of the catalytic residues, with very similar structures. However, tertiary structure analysis indicated that ScAlt2 has a more open conformation than that of ScAlt1 so that under physiological conditions, while PLP interaction with ScAlt1 allows the formation of two tautomeric PLP isomers (enolimine and ketoenamine) ScAlt2 preferentially forms the ketoenamine PLP tautomer, indicating a modified polarity of the active sites which affect the interaction of PLP with these proteins, that could result in lack of alanine transaminase activity in ScAlt2. The fact that ScAlt2 forms a catalytically active Schiff base with PLP and its position in an independent clade in “sensu strictu” yeasts suggests this protein has a yet undiscovered physiological function. PMID:29867852

Probability and Style in the Chorales of J. S. Bach

Directory of Open Access Journals (Sweden)

Matthew Woolhouse

2015-12-01

Full Text Available This paper discusses de Clercq’s (2015 contribution to our understanding of the relationship between scale degree and cadence type within Bach chorales from the perspective of style and probability. De Clercq is applauded for the diligence of this research and for attempting to synthesize findings into a practical, working model of benefit to music-theory students and educators. A literal interpretation of a premise underpinning his model—that more common musical events are more indicative of a style—is, however, found to be inconsistent. A test is described in which university students enrolled in a second-level harmony class were presented with pairs of cadences. Cadences were manipulated in various ways, primarily to investigate whether the inclusion of certain figurations would result in a perfect-authentic cadence, the most ubiquitous cadence within Bach chorales, being considered less stylistic than a never-occurring cadence. This proved to be the case, demonstrating the importance of figuration over scale degree and cadence for the accomplishment of style. De Clercq’s model is further discussed with respect to probabilistic models of music and in relation to proscriptive approaches to teaching harmony.

[Thomas Schwencke and Wolfgang Amadeus Mozart].

Science.gov (United States)

Hillen, Harry F P

2010-01-01

Thomas Schwencke (1694-1767) was Professor of Anatomy and Surgery and Lecturer in Obstetrics at the Surgical School in The Hague, the Netherlands. In 1743 he published the very first textbook on haematology. Furthermore, he described his observations on the variolation of smallpox, and published the design of a new obstetric instrument. Schwencke was physician of the city of The Hague and also physician at the court of the princes van Nassau-Weilburg. In 1765 Princess Caroline of Nassau-Weilburg invited the young Wolfgang Amadeus Mozart to perform concerts. During his Dutch tour the young Mozart fell seriously ill, probably from typhoid fever. At the request of the court Mozart was seen for a second opinion and thereafter successfully treated by Schwencke. Mozart could continue his concert tour and Schwencke's reputation as Mozart's physician was established.

Küsimus : kas Šveits on jalgpallimaa... On? Ei ole! / Wolfgang Bortlik ; intervjueerinud Andres Must

Index Scriptorium Estoniae

Bortlik, Wolfgang

2008-01-01

Vestlus Šveitsi jalgpalliajalugu käsitleva raamatu autori Wolfgang Bortlikuga, kes räägib jalgpalli positsioonist täna algavate Euroopa meistrivõistluste korraldajamaa Šveitsi paljurahvuselises ühiskonnas

Eric Bach : ilustrador de Luis de Góngora

Directory of Open Access Journals (Sweden)

María Dolores Antigüedad del Castillo Olivares

1991-01-01

Full Text Available El pintor holandés Eric Bach [Eríurt (Alemania 1911] ha mostrado durante el año 1991 sus obras como ilustrador en sendas exposiciones celebradas en Córdoba y Madrid. El artista que reside indistintamente en Munich y Barcelona, expuso las ilustraciones que ha realizado para la edición en alemán de Los veinticuatro sonetos amorosos, heroicos y fúnebres de don Luis de Góngora, edición hecha por encargo del Sr. Rüdiger Kampmann de Munich.

Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease.

Science.gov (United States)

Eriksson, D; Bianchi, M; Landegren, N; Nordin, J; Dalin, F; Mathioudaki, A; Eriksson, G N; Hultin-Rosenberg, L; Dahlqvist, J; Zetterqvist, H; Karlsson, Å; Hallgren, Å; Farias, F H G; Murén, E; Ahlgren, K M; Lobell, A; Andersson, G; Tandre, K; Dahlqvist, S R; Söderkvist, P; Rönnblom, L; Hulting, A-L; Wahlberg, J; Ekwall, O; Dahlqvist, P; Meadows, J R S; Bensing, S; Lindblad-Toh, K; Kämpe, O; Pielberg, G R

2016-12-01

Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. To understand the genetic background of Addison's disease, we utilized the extensively characterized patients of the Swedish Addison Registry. We developed an extended exome capture array comprising a selected set of 1853 genes and their potential regulatory elements, for the purpose of sequencing 479 patients with Addison's disease and 1394 controls. We identified BACH2 (rs62408233-A, OR = 2.01 (1.71-2.37), P = 1.66 × 10 -15 , MAF 0.46/0.29 in cases/controls) as a novel gene associated with Addison's disease development. We also confirmed the previously known associations with the HLA complex. Whilst BACH2 has been previously reported to associate with organ-specific autoimmune diseases co-inherited with Addison's disease, we have identified BACH2 as a major risk locus in Addison's disease, independent of concomitant autoimmune diseases. Our results may enable future research towards preventive disease treatment. © 2016 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

Reader-Response Theory: A Path Towards Wolfgang Iser (La teoría de la recepción: una ruta hacia Wolfgang Iser)

OpenAIRE

Giangiulio Lobo, Alejandra

2015-01-01

Se estudia la teoría de la recepción a partir de diferentes autores y críticos literarios, para caracterizar los distintos tipos de lectores, según cada aproximación y los procesos de lectura y creación de significado. El ensayo se centra en el enfoque fenomenológico de Wolfgang Iser sobre la recepción del lector, la generación de significado y los tipos de lectores.Reader-response theory is studied from the perspective of different authors and literary critics to characterize the different t...

PISCES and ALT-II: Juelich PSI papers

International Nuclear Information System (INIS)

Conn, R.W.; Hirooka, Y.; LaBombard, B.

1988-08-01

This publication comprises papers from the PISCES and ALT-II Programs at UCLA which were presented at the International Plasma Surface Interactions Meeting held in Juelich, FRG, on May 2-6, 1988. A list of publications from the PISCES and ALT-II contained in this report are: Deuterium pumping and erosion behavior of selected graphite materials under high flux plasma bombardment in PISCES; Erosion and redeposition behavior of selected NET-candidate materials under high-flux hydrogen, deuterium plasma bombardment in PISCES; Presheath profiles in simulated tokamak edge plasmas; Boundary asymmetries and plasma flow to the ALT-II toroidal belt pump limiter; ALT-II toroidal belt pump limiter performance in TEXTOR; and An in-situ spectroscopic erosion yield measurement with applications to sputtering and surface morphology alterations

Das Orgelbüchlein von Johann Sebastian Bach : Strukturen und innere Ordnung

NARCIS (Netherlands)

Pachlatko, F.M.

2014-01-01

The 'Little Organ Book' (O=B) is the first major cyclical work of Johann Sebastian Bach, and was probably written between 1703 and 1720. Hitherto it has been assumed that the O=B was unfinished. Of the 164 chorale titles listed in the autograph, only 46 chorales were composed. As a preliminary

Old and new questions in physics, cosmology, philosophy and theoretical biology Festschrift Yourgrau (Wolfgang)

CERN Document Server

1983-01-01

Simply to say that this is a collection of essays in honor of the late Wolfgang Yourgrau (1908-1979) is to explain, at least for-the obviously many-"insiders," the unusually wide-ranging title of the present volume. In a Foreword to the Proceedings of the First International Colloquium (focusing on logic, physical reality, and history), held at the University of Denver in May of 1966 under their leadership, Wolfgang Y ourgrau and Allen Breck wrote, in an oblique reference to C. P. Snow: "Indeed there are not two or three or four cultures: there is only one culture; our generation has lost its awareness of this . . . . Historians, logicians, physicists-all are banded in one common enterprise, namely in their des ire to weave an enlightened fabric of human knowledge. " Augment, if you will, the foregoing categories of scholars with biologists, philos­ ophers, cosmologists, and theologians-all of whom, in addition to historians, Wolf­ gang Yourgrau, by dint of his inextinguishable enthusiasm and charismatic qu...

Army AL&T, July-September 2008

Science.gov (United States)

2008-09-01

Northern Region — Wanda Reed (PCO), Joann Langston (PARC), Debbie Emerson (Alt. to PARC) Southern Region — Julie Silva (PCO), Carol Lowman (Direc- tor/PARC...Charles Jaber (PCO), Roger Engebretson, (Director/PARC), Sharon Oishi (Alt. to PARC) U.S. Army Contracting Command, Southwest Asia — Carol Estes (PCO...Robyn Villafranco, Margarita Ramirez, Diana Fernandez, Donna Reed, Michely Walton, Elisa Mendez , Cynariah Wilkins, Deinor Bolanos, Belinda Kent

Association of ALT and the metabolic syndrome among Mexican children.

Science.gov (United States)

Elizondo-Montemayor, Leticia; Ugalde-Casas, Patricia A; Lam-Franco, Lorena; Bustamante-Careaga, Humberto; Serrano-González, Mónica; Gutiérrez, Norma G; Martínez, Ubaldo

2014-01-01

Nonalcoholic fatty liver disease (NAFLD) is emerging as a component of the metabolic syndrome (MetS); Hispanics being particularly predisposed. Alanine aminotransferase (ALT) is considered a marker of NAFLD. The aim of this study was to determine the prevalence and associations between ALT elevations and MetS in normal-weight, overweight and obese Mexican children and adolescents, since data in Mexico is scarce. Body mass index (BMI), waist circumference (WC), percentage body fat, blood pressure, glucose, lipid profiles, ALT and aspartate aminotransferase (AST) were measured in 236, 6-12yo normal-weight, overweight and obese Mexicans from eight public schools. The results showed that elevated ALT (>40 IU/L) was found in 17.7% of the obese and overweight population, with no gender difference. The prevalence of elevated ALT increased linearly across BMI categories (p = 0.001), from 0.0% for the normal-weight group (95%CI 0.0-€“8.0) to 22.4% for the obese one (95%CI 16.2-€“30.2). AST/ALT ratio obese one. The prevalence of MetS was strongly associated with elevated ALT (p = 0.002), 50% in the elevated ALT group (95%CI 34.1-€“65.9) and 24.1% in the normal ALT one (95%CI 18.1-€“31.3). There was also a strong association between MetS and an AST/ALT ratio obese children. © 2014 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

Changes in erectile dysfunction over time in relation to Framingham cardiovascular risk in the Boston Area Community Health (BACH) Survey.

Science.gov (United States)

Fang, Shona C; Rosen, Raymond C; Vita, Joseph A; Ganz, Peter; Kupelian, Varant

2015-01-01

Erectile dysfunction (ED) is associated with cardiovascular disease (CVD); however, the association between change in ED status over time and future underlying CVD risk is unclear. The aim of this study was to investigate the association between change in ED status and Framingham CVD risk, as well change in Framingham risk. We studied 965 men free of CVD in the Boston Area Community Health (BACH) Survey, a longitudinal cohort study with three assessments. ED was assessed with the five-item International Index of Erectile Function at BACH I (2002-2005) and BACH II (2007-2010) and classified as no ED/transient ED/persistent ED. CVD risk was assessed with 10-year Framingham CVD risk algorithm at BACH I and BACH III (2010-2012). Linear regression models controlled for baseline age, socio-demographic and lifestyle factors, as well as baseline Framingham risk. Models were also stratified by age (≥/< 50 years). Framingham CVD risk and change in Framingham CVD risk were the main outcome measures. Transient and persistent ED was significantly associated with increased Framingham risk and change in risk over time in univariate and age-adjusted models. In younger men, persistent ED was associated with a Framingham risk that was 1.58 percentage points higher (95% confidence interval [CI]: 0.11, 3.06) and in older men, a Framingham risk that was 2.54 percentage points higher (95% CI: -1.5, 6.59), compared with those without ED. Change in Framingham risk over time was also associated with transient and persistent ED in men <50 years, but not in older men. Data suggest that even after taking into account other CVD risk factors, transient and persistent ED is associated with Framingham CVD risk and a greater increase in Framingham risk over time, particularly in younger men. Findings further support clinical assessment of CVD risk in men presenting with ED, especially those under 50 years. © 2014 International Society for Sexual Medicine.

Wolfgang Pauli et l'arrière-plan de la physique

CERN Multimedia

Bringuier, Eric

2003-01-01

"Wolfgang Pauli est l'une des figures scientifiques majeures du XXe siècle. Ses contributions sur la structure de l'atome ont été déterminantes pour l'établissement de la théorie quantique. Mais une grande partie de son activité fut aussi consacrée à une réflexion plus large sur les processus cognitifs. L'une de ses obsessions: trouver un langage commun pour décrire le monde physique et le monde psychique" (3 pages)

Hepatic HMOX1 expression positively correlates with Bach-1 and miR-122 in patients with HCV mono and HIV/HCV coinfection.

Science.gov (United States)

Jabłonowska, Elżbieta; Wójcik, Kamila; Szymańska, Bożena; Omulecka, Aleksandra; Cwiklińska, Hanna; Piekarska, Anna

2014-01-01

To analyze the expression of HMOX1 and miR-122 in liver biopsy samples obtained from HCV mono-and HIV/HCV co-infected patients in relation to selected clinical parameters, histological examination and IL-28B polymorphism as well as to determine whether HMOX1 expression is dependent on Bach-1. The study group consisted of 90 patients with CHC: 69 with HCV mono and 21 with HIV/HCV co-infection. RT-PCR was used in the analysis of HMOX1, Bach-1 and miR-122 expression in liver biopsy samples and in the assessment of IL-28B single-nucleotide polymorphism C/T (rs12979860) in the blood. Moreover in liver biopsy samples an analysis of HO-1 and Bach-1 protein level by Western Blot was performed. HCV mono-infected patients, with lower grading score (G600000 IU/mL) demonstrated higher expression of HMOX1. In patients with HIV/HCV co-infection, the expression of HMOX1 was lower in patients with lower lymphocyte CD4 count and higher HIV viral load. IL28B polymorphism did not affect the expression of either HMOX1 or miR-122. Higher HMOX1 expression correlated with higher expression of Bach-1 (Spearman's ρ = 0.586, p = 0.000001) and miR-122 (Spearman's ρ = 0.270, p = 0.014059). HMOX1 and miR-122 play an important role in the pathogenesis of CHC in HCV mono-and HIV/HCV co-infected patients. Reduced expression of HMOX1 in patients with HIV/HCV co-infection may indicate a worse prognosis in this group. Our results do not support the importance of Bach-1 in repression of HMOX1 in patients with chronic hepatitis C.

A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.

Science.gov (United States)

Pazderska, Agnieszka; Oftedal, Bergithe E; Napier, Catherine M; Ainsworth, Holly F; Husebye, Eystein S; Cordell, Heather J; Pearce, Simon H S; Mitchell, Anna L

2016-11-01

Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions. We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD. This case-control association study was performed in two phases using Taqman chemistry. In the first phase, the rs3757247 SNP was genotyped in 358 UK AAD subjects and 166 local control subjects. Genotype data were also available from 5154 healthy UK controls from the Wellcome Trust (WTCCC2) for comparison. In the second phase, the SNP was genotyped in a validation cohort comprising 317 Norwegian AAD subjects and 365 controls. The frequency of the minor T allele was significantly higher in subjects with AAD from the United Kingdom compared to both the local and WTCCC2 control cohorts (58% vs 45 and 48%, respectively) (local controls, P = 1.1 × 10 -4 ; odds ratio [OR], 1.68; 95% confidence interval [CI], 1.29-2.18; WTCCC2 controls, P = 1.4 × 10 -6 ; OR, 1.44; 95% CI, 1.23-1.69). This finding was replicated in the Norwegian validation cohort (P = .0015; OR, 1.41; 95% CI, 1.14-1.75). Subgroup analysis showed that this association is present in subjects with both isolated AAD (OR, 1.53; 95% CI, 1.22-1.92) and autoimmune polyglandular syndrome type 2 (OR, 1.37; 95% CI, 1.12-1.69) in the UK cohort, and with autoimmune polyglandular syndrome type 2 in the Norwegian cohort (OR, 1.58; 95% CI, 1.22-2.06). We have demonstrated, for the first time, that allelic variability at the BACH2 locus is associated with susceptibility to AAD. Given its association with multiple autoimmune conditions, BACH2 can be considered a "universal" autoimmune susceptibility locus.

Surface and Subsurface Meltwater Ponding and Refreezing on the Bach Ice Shelf, Antarctic Peninsula

Science.gov (United States)

Willis, I.; Haggard, E.; Benedek, C. L.; MacAyeal, D. R.; Banwell, A. F.

2017-12-01

There is growing concern about the stability and fate of Antarctic ice shelves, as four major ice shelves on the Antarctic Peninsula have completely disintegrated since the 1950s. Their collapse has been linked to the southward movement of the -9 oC mean annual temperature isotherm. The proximal causes of ice shelf instability are not fully known, but an increase in surface melting leading to water ponding and ice flexure, fracture and calving has been implicated. Close to the recently collapsed Wilkins Ice Shelf, the Bach Ice Shelf (72°S 72°W) may be at risk from break up in the near future. Here, we document the changing surface hydrology of the Bach Ice Shelf between 2001 and 2017 using Landsat 7 & 8 imagery. Extensive surface water is identified across the Bach Ice Shelf and its tributary glaciers. Two types of drainage system are observed, drainage into firn via simple stream networks and drainage into the ocean via more complex networks. There are differences between the surface hydrology on the ice shelf and the tributary glaciers, as well as variations within and between summer seasons linked to surface air temperature fluctuations. We also document the changing subsurface hydrology of the ice shelf between 2014 and 2017 using Sentinel 1 A/B SAR imagery. Forty-five subsurface features are identified and analysed for their patterns and temporal evolution. Fourteen of the features show similar characteristics to previously-identified buried lakes and some occur in areas associated with surface lakes in previous years. The buried lakes show seasonal variability in area and surface backscatter, which varies with surface air temperature, and are consistent with the presence, enlargement and contraction of liquid water bodies. Buried lakes are an overlooked source of water loading on ice shelves, which may contribute to ice shelf flexure and potential fracture.

[Wolfgang Amadeus Mozart. A urological pathography].

Science.gov (United States)

Hatzinger, M; Häcker, A; Langbein, S; Bross, S; Honeck, P; Alken, P

2006-04-01

The death of Wolfgang Amadeus Mozart was mysterious from the very first day, and cause of wildest speculation and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious death of Mozart with increasing intensity. By means of letters from his father Leopold, his sister "Nannerl", himself and reports from his physicians and contemporaries, we would like to create a medical pathography. The rumour that Mozart was poisoned appeared soon after his early death at the age of 35 on December 5th 1791, and was kept up persistently. Accused were the physician van Swieten, Mozart's freemason's loge and the royal band master Salieri. Mozart, however, died due to chronic kidney disease and ultimately due to uraemia. Once the renal damage has reached a certain point, a minimum of additional stress leads to decompensation. This catastrophe occurs typically within the fourth decade of life. When listening to Mozart's music, we should remember that this apparently happy person was actually a premature adult robbed of his childhood, whose short life was an endless chain of indisposition, over fatigue, misery, concern and illness.

The large eyes of Wolfgang Amadeus Mozart. (On the occasion of the 250th Mozart anniversary year)

NARCIS (Netherlands)

Zegers, Richard H. C.; Saeed, Peerooz; Wiersinga, Wilmar M.

2005-01-01

This article discusses the eyes of Wolfgang Amadeus Mozart (1756-1791) which, based on portraits, can be said to have a certain noticeable feature--some degree of exophthalmos. In fact, even contemporary observers made particular mention of Mozart's eyes being large. Although cicatricial ectropion,

Alternative Liquid Fuels Simulation Model (AltSim).

Energy Technology Data Exchange (ETDEWEB)

Williams, Ryan; Baker, Arnold Barry; Drennen, Thomas E.

2009-12-01

The Alternative Liquid Fuels Simulation Model (AltSim) is a high-level dynamic simulation model which calculates and compares the production and end use costs, greenhouse gas emissions, and energy balances of several alternative liquid transportation fuels. These fuels include: corn ethanol, cellulosic ethanol from various feedstocks (switchgrass, corn stover, forest residue, and farmed trees), biodiesel, and diesels derived from natural gas (gas to liquid, or GTL), coal (coal to liquid, or CTL), and coal with biomass (CBTL). AltSim allows for comprehensive sensitivity analyses on capital costs, operation and maintenance costs, renewable and fossil fuel feedstock costs, feedstock conversion ratio, financial assumptions, tax credits, CO{sub 2} taxes, and plant capacity factor. This paper summarizes the structure and methodology of AltSim, presents results, and provides a detailed sensitivity analysis. The Energy Independence and Security Act (EISA) of 2007 sets a goal for the increased use of biofuels in the U.S., ultimately reaching 36 billion gallons by 2022. AltSim's base case assumes EPA projected feedstock costs in 2022 (EPA, 2009). For the base case assumptions, AltSim estimates per gallon production costs for the five ethanol feedstocks (corn, switchgrass, corn stover, forest residue, and farmed trees) of $1.86, $2.32, $2.45, $1.52, and $1.91, respectively. The projected production cost of biodiesel is $1.81/gallon. The estimates for CTL without biomass range from $1.36 to $2.22. With biomass, the estimated costs increase, ranging from $2.19 per gallon for the CTL option with 8% biomass to $2.79 per gallon for the CTL option with 30% biomass and carbon capture and sequestration. AltSim compares the greenhouse gas emissions (GHG) associated with both the production and consumption of the various fuels. EISA allows fuels emitting 20% less greenhouse gases (GHG) than conventional gasoline and diesels to qualify as renewable fuels. This allows several of the

'You have to go through the atomic shell'. Conversation with the nuclear physicist and Nobel Prize winner Wolfgang Paul. 'Sie muessen durch die Atomhuelle hindurch'. Gespraech mit dem Kernphysiker und Nobelpreistraeger Wolfgang Paul

Energy Technology Data Exchange (ETDEWEB)

Steiner, P.

1994-01-01

The contribution reflects an interview with the nuclear physicist Prof. Dr. Wolfgang Paul, to whom the Nobel prize has been awarded for the electro-magnetic trap for loaded and unloaded particles named after him. The centre of the discussion is the professional development with regard to main fields of research. (BWI)

Muusikamaailm : Bachi orel Leipzigis valmis. XX sajandi ooperid laval. Huddersfieldi festivalil. "Liszt ja Bach" Weimaris / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Lepzigi Thomaskirches taastati Bachi-aegne barokkorel. Flandria Ooperis, Hamburgi Riigiooperis ja Brüsseli Thétre de la Monnaie's lavastuvatest XX saj. heliloojate ooperitest. 16.-26. nov. toimuvast Huddersfieldi kaasaegse muusika festivalist Inglismaal. Festivalist "Liszt ja Bach" Weimaris

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

DEFF Research Database (Denmark)

Lafferty-Whyte, K; Cairney, C J; Will, M B

2009-01-01

Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular le......TERT in different tumour types and normal tissues. We also show evidence to suggest a novel mesenchymal stem cell origin for ALT immortalization in cell lines and mesenchymal tissues....

Wolfgang Amadeus Mozart--controversies regarding his illnesses and death: a bibliographic review.

Science.gov (United States)

Dawson, William J

2010-06-01

More has been written about Mozart's illnesses and death than for any other composer. An exploration of PAMA's Bibliography of Performing Arts Medicine provides the data for this review. The bibliography contained 136 entries that pertained to Wolfgang Amadeus Mozart. Of these, 81 were available to the author, either in printed or electronic copy. In order to provide a clearer historical perspective on this topic, this review assembles information pertaining to illnesses and other medical problems that occurred during Mozart's life as well as those purportedly contributing to his death.

21 CFR 862.1030 - Alanine amino transferase (ALT/SGPT) test system.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Alanine amino transferase (ALT/SGPT) test system... Test Systems § 862.1030 Alanine amino transferase (ALT/SGPT) test system. (a) Identification. An alanine amino transferase (ALT/SGPT) test system is a device intended to measure the activity of the...

ELEVATED ALT AND AST IN AN ASYMPTOMATIC PERSON

Directory of Open Access Journals (Sweden)

KEW ST

2009-01-01

Full Text Available -Abnormal liver function test with raised alanine aminotransferase (ALT and raised aspartate aminotransferase (AST are commonly seen in primary care setting. -Chronic alcohol consumption, drugs, non-alcoholic steatohepatitis (NASH and chronic viral hepatitis are common causes associated with raised ALT and AST. -In chronic viral hepatitis, the elevation of liver enzyme may not correlate well with the degree of liver damage. -Non-hepatic causes of raised ALT and AST include polymyositis, acute muscles injury, acute myocardial infarction and hypothyroidism. -In the primary care setting, the doctor should obtain a complete history regarding the risk factors for viral hepatitis, substance abuse and request investigations accordingly. -Suspected chronic viral hepatitis and liver cirrhosis are best referred to hepatologist for further management.

ALT-II armor tile design for upgraded TEXTOR operation

International Nuclear Information System (INIS)

Newberry, B.L.; McGrath, R.T.; Watson, R.D.

1994-01-01

The upgrade of the TEXTOR tokamak at KFA Julich will be completed in the spring of 1994. The upgrade will extend the TEXTOR pulse length from 5 seconds to 10 seconds. The auxiliary heating systems are also scheduled to be upgraded so that eventually a total of 8.0 MW auxiliary heating will be available through a combination of neutral beam injection and radio frequency heating. Originally, the inertially cooled armor tiles on the full toroidal belt Advanced Limiter Test - II (ALT-II) were designed for 5-second operation with a total heating power of 6.0 MW. The upgrade of TEXTOR will increase the energy deposited per pulse onto ALT-II by more than 300%. Consequently, the graphite armor tiles for ALT-II had to be redesigned in order to increase their thermal inertia and, thereby, avoid excessively high graphite armor surface temperatures that would lead to unacceptable contamination of the plasma. The armor tile thermal inertia had been increase primarily by expanding the radial thickness of the tiles from 17 mm to 20 mm. This increase in radial tile dimension will reduce the overall pumping efficiency of the ALT-II pump limiter by about 30%. The final armor tile design was a compromise between increasing the power handling capability and reducing the particle exhaust efficiency of ALT-II. The reduction in exhaust efficiency is unfortunate, but could only be avoided by active cooling of the ALT-II armor tiles. The active cooling option was too complicated and expensive to be considered at this time

Famous people with Tourette's syndrome: Dr. Samuel Johnson (yes) & Wolfgang Amadeus Mozart (may be): Victims of Tourette's syndrome?

Science.gov (United States)

Bhattacharyya, Kalyan B; Rai, Saurabh

2015-01-01

Tourette's syndrome is a clinical condition characterized by multiple motor tics and vocal tics which occurs in the age range 5-25 years and the intensity of the symptoms changes with time. It is felt that at least two remarkable personalities namely, Dr. Samuel Johnson from England, a man of letters and the compiler of the first ever English dictionary, and Wolfgang Amadeus Mozart from Austria, one of the greatest musical genius of all time, possibly suffered from this condition. Tourette's syndrome is often described as the classical borderzone between neurology and psychiatry and every neurologist wonders at the curious and fascinating clinical features of this condition. It seems that at least two remarkable personalities, Dr. Samuel Johnson, a man of letters and the first person to compile an English dictionary, and Wolfgang Amadeus Mozart, arguably the most creative musical composer of all time, were possibly afflicted with this condition.

Simfoni No. 40 Bagian Pertama Wolfgang Amadeus Mozart

Directory of Open Access Journals (Sweden)

F. XAVERIA DIAH K

2013-11-01

Full Text Available The First Symfoni No 40 Wolfgang Amadeus Mozart. Symphony is a great composition, whichconventionally consists of four parts. At the end of the eighteenth century it became the main format of orchestralmusic. However, it became prominent at the time of Beethoven. Symphony is a great and ambitious piece of musicsince it is played for 20-45 minutes in length, containing an expansion of tone colors and dynamics of classicalorchestra. It has been known that classical symphony usually consists of four parts inciting broader emotion bythe created tempo and nuance. Mozart’s three last symphonies are Mozart’s masterpieces and Symphony No. 40,for example, contains connotations of romantic signs ignored by his predecessors. Although Symphony No. 40employs minor tones, it is not sad but cheerful, playful, passionful, and dramatic. The fi rst part of the Symphonyuses Allegro Sonata format which consists of three parts, namely exposition, development and recapitulation.

Efectividad de la terapia floral de Bach en pacientes con alcoholismo crónico Effectiveness of Bach flower therapy in patients with chronic alcoholism

Directory of Open Access Journals (Sweden)

Noraima Contrera Vega

2012-04-01

Full Text Available Se realizó una intervención terapéutica en 15 pacientes con alcoholismo crónico, pertenecientes al Grupo Básico de Trabajo No. 3 del Policlínico Docente "Armando García Aspurú", de Santiago de Cuba, desde junio de 2008 hasta febrero de 2009, a fin de evaluar la efectividad de la terapia floral de Bach en el tratamiento de dichos pacientes, para lo cual se aplicó primero un esquema terapéutico general y luego individual. Se emplearon la media aritmética para cuantificar los datos, la desviación estándar para estimar la variabilidad y el porcentaje como medida de resumen, con un intervalo de confianza de 95 %. La favorable evolución observada en la mayoría de ellos puso de manifiesto la utilidad de esta terapia para disminuir manifestaciones psicosomáticas de ansiedad, depresión e insomnio y mejorar así la calidad de vida, tanto de los afectados como de sus familiares.A therapeutic intervention was performed in 15 patients with chronic alcoholism, belonging to the Working Basic Group No. 3 of "Armando García Aspurú" Teaching Polyclinic in Santiago de Cuba, from June 2008 to February 2009, in order to evaluate the effectiveness of Bach flower therapy in the treatment of these patients, thus applying a therapeutic regimen generally first and then individually. The arithmetic mean to quantify the data, the standard deviation to estimate the variability and the percentage as summary measure were used, with a 95% confidence interval. The favorable course observed in most of them demonstrated the usefulness of this therapy to reduce psychosomatic manifestations of anxiety, depression and insomnia and improve the life quality of both patients and their families.

Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1.

Science.gov (United States)

Aayadi, Hoda; Mittal, Smriti P K; Deshpande, Anjali; Gore, Makarand; Ghaskadbi, Saroj S

2017-11-01

Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta (GSK-3β). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA. Expression of BTB and CNC homolog 1 (BACH-1), another regulator of HO-1, is also down-regulated by up-regulating microRNA 98 (miR-98), a negative regulator of BACH-1. Thus, geraniin up-regulates HO-1 expression both through activating its positive regulator Nrf-2 and by down-regulating its negative regulator BACH-1. Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity. [BMB Reports 2017; 50(11): 560-565].

General Time-Division AltBOC Modulation Technique for GNSS Signals

Directory of Open Access Journals (Sweden)

Z. Zhou

2018-04-01

Full Text Available In this paper, a general time-division alternate binary offset carrier (GTD-AltBOC modulation method is proposed, which is an extension of TD-AltBOC and time-multiplexed offset-carrier quadrature phase shift keying (TMOC-QPSK with high design flexibility. In this method, binary complex subcarriers and a time-division technique with flexible time slot assignment are used to achieve constant envelope modulation of the signal components with a variable power allocation ratio (PAR. The underlying principle of GTD-AltBOC and the constraints related to the PAR are investigated. For the generation of GTD-AltBOC signals, a lookup table (LUT-based scheme is presented; the minimum required clock rate is half or less of that for existing non-time-division methods. The receiver processing complexities are analyzed for three typical receiving modes, and the power spectral densities (PSDs, cross-correlation functions, multiplexing efficiencies and code-tracking performance are simulated; the results show that GTD-AltBOC enables a significant decrease in receiving complexity compared with existing methods while maintaining high performance in terms of multiplexing efficiency and code tracking.

Effect of Instruction in Appropriate Rubato Usage on Performances of Mozart and Bach: Replication and Extension

Science.gov (United States)

Johnson, Christopher M.; Madsen, Clifford K.; Geringer, John M.

2012-01-01

The purpose of this study was to investigate how instruction in the use of rhythmic nuances influences subsequent timings of a musical performance. Volunteer participants were asked to listen to and alter a performance of an excerpt from Mozart's "Concerto for Horn and Orchestra No. 2" and Bach's "Suite Number 3 for Violoncello solo, Bourree…

Effect of Instruction in Appropriate Rubato Usage on the Onset Timings of Musicians in Performances of Bach.

Science.gov (United States)

Johnson, Christopher M.

2000-01-01

Examines the effect of instruction in the use of specific rhythmic nuances on the timings of a musical performance. Forty volunteer upper-division and graduate students performed Johann Sebastian Bach's Suite no. 3 for Violoncello solo, Bouree no. 1, using a computer software program. Discusses the results. (CMK)

Editorial ALT-J non-electronica

Directory of Open Access Journals (Sweden)

Gabriel Jacobs

1997-12-01

Full Text Available The ALT Executive Committee has discussed on a number of occasions the question of making ALT-J wholly available in electronic form on our Web site (at present only the editorial and abstracts of papers appear, and even of turning it into a full-blown electronic journal. I have gently but consistently opposed this move, on occasions to the intense irritation of some of my fellow members, and always at the risk of appearing to be a Luddite. Explicitly ('Who, if not we as learning technologists, should be in the forefront of the soon-to-happen electronic-journal revolution?' and implicitly ('It is estimated that within two years, paper-based journals will be considered the dinosaurs of the academic world', I have increasingly come under pressure to accede to an apparently unstoppable, apparently imminent change in the method and form of scholarly publication. I set out here my reasons for my continued resistance.

Case Report: Gollop-Wolfgang Complex in a 5 month old baby [v3; ref status: indexed, http://f1000r.es/53y

Directory of Open Access Journals (Sweden)

Ihtesham A. Qureshi

2015-02-01

Full Text Available Skeletal dysplasias are disorders associated with a generalized abnormality in the skeleton. The Gollop-Wolfgang complex (GWC is a limb deficiency disorder and an unusual limb malformation with highly variable manifestations. Here we report an interesting case of a 5-month old male baby from India with Gollop-Wolfgang Complex showing bifurcation of the right femur, ectrodactyly of both feet, ectrodactyly of left hand, syndactyly of right hand and unusual presentation of bilateral fibular agenesis and caudal (Sacrococcygeal agenesis. The etiology of GWC in this 5 month old male baby could possibly be attributed to spontaneous gene mutation. The clinical, radiographic findings and the unusual presentation are presented in detail.

Sturm und Drang na música para teclado de Wilhelm Friedemann Bach: evidências reveladas na Polonaise No.4 em Ré menor Sturm und Drang in the keyboard music of Wilhelm Friedemann Bach: detected evidences in Polonaise N.4, in D minor

Directory of Open Access Journals (Sweden)

Stella Almeida Rosa

2011-12-01

Full Text Available Este trabalho propõese a revelar elementos contextuais e musicais, especialmente aqueles ligados à expressividade, que aproximem a obra para teclado de Wilhelm Friedemann Bach ao movimento Sturm und Drang, ocorrido na Alemanha no início da segunda metade do século XVIII, através do reconhecimento dos procedimentos literários e musicais envolvidos e da análise da Polonaise nº 4, em Ré menor, como obra representativa do que se pretende demonstrar.This paper intends to point out contextual and musical elements, especially those relative to expressiveness, that brings Wilhelm Friedemann Bach's keyboard works close to German Sturm und Drang, that happened during the beginning of the second half of the eighteenth century, through the identification of the literary and musical procedures and the analysis of the Polonaise number 4, in D minor, as a representative work of this style.

Preliminary design analysis of the ALT-II limiter for TEXTOR

International Nuclear Information System (INIS)

Koski, J.A.; Boyd, R.D.; Kempka, S.M.; Romig, A.D. Jr.; Smith, M.F.; Watson, R.D.; Whitley, J.B.; Conn, R.W.; Grotz, S.P.

1983-01-01

Installation of a large toroidal belt pump limiter, Advanced Limiter Test II (ALT-II), on the TEXTOR tokamak at Juelich, FRG is anticipated for early 1986. This paper discusses the preliminary mechanical design and materials considerations undertaken as part of the feasibility study phase for ALT-II

ALT-II armor tile design for upgraded TEXTOR operation

International Nuclear Information System (INIS)

Newberry, B.L.; McGrath, R.T.; Watson, R.D.; Kohlhaas, W.; Finken, K.H.

1994-01-01

The upgrade of the TEXTOR tokamak at KFA Juelich was recently completed. This upgrade extended the TEXTOR pulse length from 5 seconds to 10 seconds. The auxiliary heating was increased to a total of 8.0 MW through a combination of neutral beam injection and radio frequency heating. Originally, the inertially cooled armor tiles of the full toroidal belt Advanced Limiter Test -- II (ALT-II) were designed for a 5-second operation with total heating of 6.0 MW. The upgrade of TEXTOR will increase the energy deposited per pulse onto the ALT-II by about 300%. Consequently, the graphite armor tiles for the ALT-II had to be redesigned to avoid excessively high graphite armor surface temperatures that would lead to unacceptable contamination of the plasma. This redesign took the form of two major changes in the ALT-II armor tile geometry. The first design change was an increase of the armor tile thermal mass, primarily by increasing the radial thickness of each tile from 17 mm to 20 mm. This increase in the radial tile dimension reduces the overall pumping efficiency of the ALT-II pump limiter by about 30%. The reduction in exhaust efficiency is unfortunate, but could be avoided only by active cooling of the ALT-II armor tiles. The active cooling option was too complicated and expensive to be considered at this time. The second design change involved redefining the plasma facing surface of each armor tile in order to fully utilize the entire surface area. The incident charged particle heat flux was distributed uniformly over the armor tile surfaces by carefully matching the radial, poloidal and toroidal curvature of each tile to the plasma flow in the TEXTOR boundary layer. This geometry redefinition complicates the manufacturing of the armor tiles, but results in significant thermal performance gains. In addition to these geometry upgrades, several material options were analyzed and evaluated

"Leaders," "Followers" and Collective Group Support in Learning "Art Music" in an Amateur Composer-Oriented Bach Choir

Science.gov (United States)

Einarsdottir, Sigrun Lilja

2014-01-01

The purpose of this paper is to demonstrate how amateur choral singers experience collective group support as a method of learning "art music" choral work. Findings are derived from a grounded-theory based, socio-musical case study of an amateur "art music" Bach Choir, in the process of rehearsing and performing the Mass in B…

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.

Science.gov (United States)

Mateos-Gomez, Pedro A; Kent, Tatiana; Deng, Sarah K; McDevitt, Shane; Kashkina, Ekaterina; Hoang, Trung M; Pomerantz, Richard T; Sfeir, Agnel

2017-12-01

Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone DNA repair by alternative nonhomologous end joining (alt-NHEJ). Here we present structure-function analyses that reveal that, in addition to the polymerase domain, Polθ-helicase activity plays a central role during double-strand break (DSB) repair. Our results show that the helicase domain promotes chromosomal translocations by alt-NHEJ in mouse embryonic stem cells and also suppresses CRISPR-Cas9- mediated gene targeting by homologous recombination (HR). In vitro assays demonstrate that Polθ-helicase activity facilitates the removal of RPA from resected DSBs to allow their annealing and subsequent joining by alt-NHEJ. Consistent with an antagonistic role for RPA during alt-NHEJ, inhibition of RPA1 enhances end joining and suppresses recombination. Taken together, our results reveal that the balance between HR and alt-NHEJ is controlled by opposing activities of Polθ and RPA, providing further insight into the regulation of repair-pathway choice in mammalian cells.

Bach Flower Remedies for psychological problems and pain: a systematic review

Directory of Open Access Journals (Sweden)

Langley Tessa

2009-05-01

Full Text Available Abstract Background Bach Flower Remedies are thought to help balance emotional state and are commonly recommended by practitioners for psychological problems and pain. We assessed whether Bach Flower Remedies (BFRs are safe and efficacious for these indications by performing a systematic review of the literature. Methods We searched MEDLINE®, Embase, AMED, and the Cochrane Library from inception until June 2008 and performed a hand-search of references from relevant key articles. For efficacy, we included all prospective studies with a control group. For safety, we also included retrospective, observational studies with more than 30 subjects. Two authors abstracted data and determined risk of bias using a recognised rating system of trial quality. Results Four randomised controlled trials (RCTs and two additional retrospective, observational studies were identified and included in the review. Three RCTs of BFRs for students with examination anxiety, and one RCT of BFRs for children with attention-deficit hyperactivity disorder (ADHD showed no overall benefit in comparison to placebo. Due to the number and quality of the studies the strength of the evidence is low or very low. We did not find any controlled prospective studies regarding the efficacy of BFRs for pain. Only four of the six studies included for safety explicitly reported adverse events. Conclusion Most of the available evidence regarding the efficacy and safety of BFRs has a high risk of bias. We conclude that, based on the reported adverse events in these six trials, BFRs are probably safe. Few controlled prospective trials of BFRs for psychological problems and pain exist. Our analysis of the four controlled trials of BFRs for examination anxiety and ADHD indicates that there is no evidence of benefit compared with a placebo intervention.

Treasures in Heaven and on Earth : Poverty and Abundance in the Life and Sacred Cantatas of Johann Sebastian Bach

NARCIS (Netherlands)

Heber, N.

2017-01-01

This PhD dissertation explores poverty and abundance in Bach’s life and sacred cantatas and inquires how he himself might have handled the tension between the material and spiritual aspects. Although his career was increasingly lucrative, Bach did not amass significant wealth. In 1730, he complained

Famous people with Tourette′s syndrome: Dr. Samuel Johnson (yes & Wolfgang Amadeus Mozart (may be: Victims of Tourette′s syndrome?

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Kalyan B Bhattacharyya

2015-01-01

Full Text Available Tourette′s syndrome is a clinical condition characterized by multiple motor tics and vocal tics which occurs in the age range 5-25 years and the intensity of the symptoms changes with time. It is felt that at least two remarkable personalities namely, Dr. Samuel Johnson from England, a man of letters and the compiler of the first ever English dictionary, and Wolfgang Amadeus Mozart from Austria, one of the greatest musical genius of all time, possibly suffered from this condition. Tourette′s syndrome is often described as the classical borderzone between neurology and psychiatry and every neurologist wonders at the curious and fascinating clinical features of this condition. It seems that at least two remarkable personalities, Dr. Samuel Johnson, a man of letters and the first person to compile an English dictionary, and Wolfgang Amadeus Mozart, arguably the most creative musical composer of all time, were possibly afflicted with this condition.

Göttliche Liebes=Flamme : De lutherse leer van de Heilige Geest en haar invloed op Johann Sebastian Bach

NARCIS (Netherlands)

Zwitser, M.S.

2012-01-01

In the 1990s, the discussion about Bach and the Holy Spirit followed was revived after Renate Steiger’s (re)discovery of an emblem by Johann Saubert, in which the alto is described as the voice of the Holy Spirit in the believer’s heart. Despite the lively debate and some illuminating

Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.

Science.gov (United States)

Jeyapalan, Jennie N; Varley, Helen; Foxon, Jenny L; Pollock, Raphael E; Jeffreys, Alec J; Henson, Jeremy D; Reddel, Roger R; Royle, Nicola J

2005-07-01

Immortal human cells maintain telomere length by the expression of telomerase or through the alternative lengthening of telomeres (ALT). The ALT mechanism involves a recombination-like process that allows the rapid elongation of shortened telomeres. However, it is not known whether activation of the ALT pathway affects other sequences in the genome. To address this we have investigated, in ALT-expressing cell lines and tumours, the stability of tandem repeat sequences known to mutate via homologous recombination in the human germline. We have shown extraordinary somatic instability in the human minisatellite MS32 (D1S8) in ALT-expressing (ALT+) but not in normal or telomerase-expressing cell lines. The MS32 mutation frequency varied across 15 ALT+ cell lines and was on average 55-fold greater than in ALT- cell lines. The MS32 minisatellite was also highly unstable in three of eight ALT+ soft tissue sarcomas, indicating that somatic destabilization occurs in vivo. The MS32 mutation rates estimated for two ALT+ cell lines were similar to that seen in the germline. However, the internal structures of ALT and germline mutant alleles are very different, indicating differences in the underlying mutation mechanisms. Five other hypervariable minisatellites did not show elevated instability in ALT-expressing cell lines, indicating that minisatellite destabilization is not universal. The elevation of MS32 instability upon activation of the ALT pathway and telomere length maintenance suggests there is overlap between the underlying processes that may be tractable through analysis of the D1S8 locus.

Übersetzungskritische Untersuchung des Romans „An diesem Dienstag“ Wolfgang Borcherts

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Tahsin Aktaş

2006-10-01

Full Text Available This study focused on how implicit expressions (idioms used in the novel entitled“An Diesem Dienstag” by Wolfgang Borchert, one of the most renowned writers of Germanliterature, are trasferred to the Turkish language. Such expressions are extremely important inthat they bring forth the aesthetic and artistic value of literary texts. For this reason, theseexpressions need to be translated into appropriate corresponding expressions in the targetlanguage. Implicit expressions are culture-bound; for this reason a translator may facedifficulties when he is transferring them to the target language a factor which may causesome of the artistic and aesthetic value of the original text to be lost. This study attempted toput forth the translator’s attitude and his conception of translation in the transfer of implicitexpressions using an objective critical research method.

Wolfgang Amadeus Mozart: the death of a genius.

Science.gov (United States)

Hatzinger, Martin; Hatzinger, Jurgen; Sohn, Michael

2013-01-01

The early and unexpected death of Wolfgang Amadeus Mozart (Salzburg, 1756 - Vienna, 1791) was a mystery from the very first day and the subject of wildest speculations and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious death of Mozart with increasing intensity. The aim of this article was to recreate Mozart's pathography relying on the his correspondence with father Leopold and sister Nannerl and on reports from his physicians and contemporaries. The rumour that Mozart was poisoned followed shortly after his death on 5 December 1791, at the age of 35, and has survived to this day. The alleged culprits were his physician van Swieten, Mozart's freemasons lodge, and the Imperial Chapel Master Salieri. Mozart however died of chronic kidney disease and ultimately of uraemia. If kidney damage reaches a critical point, even a minimum additional stress can lead to its failure. This usually occurs in the fourth decade of life. Next time we listen to Mozart, we should remember that this apparently happy person was actually a precocious boy, ripped of his childhood, whose short life was an endless chain of complaints, fatigue, misery, concern, and malady.

Production of the Allergenic Protein Alt a 1 by Alternaria Isolates from Working Environments

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Justyna Skóra

2015-02-01

Full Text Available The aim of the study was to evaluate the ability of Alternaria isolates from workplaces to produce Alt a 1 allergenic protein, and to analyze whether technical materials (cellulose, compost, leather present within the working environment stimulate or inhibit Alt a 1 production (ELISA test. Studies included identification of the isolated molds by nucleotide sequences analyzing of the ITS1/ITS2 regions, actin, calmodulin and Alt a 1 genes. It has been shown that Alternaria molds are significant part of microbiocenosis in the archive, museum, library, composting plant and tannery (14%–16% frequency in the air. The presence of the gene encoding the Alt a 1 protein has been detected for the strains: Alternaria alternata, A. lini, A. limoniasperae A. nobilis and A. tenuissima. Environmental strains produced Alt a 1 at higher concentrations (1.103–6.528 ng/mL than a ATCC strain (0.551–0.975 ng/mL. It has been shown that the homogenization of the mycelium and the use of ultrafiltration allow a considerable increase of Alt a 1 concentration. Variations in the production of Alt a 1 protein, depend on the strain and extraction methods. These studies revealed no impact of the technical material from the workplaces on the production of Alt a 1 protein.

PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

International Nuclear Information System (INIS)

Thulin, Petra; Rafter, Ingalill; Stockling, Kenneth; Tomkiewicz, Celine; Norjavaara, Ensio; Aggerbeck, Martine; Hellmold, Heike; Ehrenborg, Ewa; Andersson, Ulf; Cotgreave, Ian; Glinghammar, Bjoern

2008-01-01

In this work, we investigated a potential mechanism behind the observation of increased aminotransferase levels in a phase I clinical trial using a lipid-lowering drug, the peroxisome proliferator-activated receptor (PPAR) α agonist, AZD4619. In healthy volunteers treated with AZD4619, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were elevated without an increase in other markers for liver injury. These increases in serum aminotransferases have previously been reported in some patients receiving another PPARα agonist, fenofibrate. In subsequent in vitro studies, we observed increased expression of ALT1 protein and mRNA in human hepatocytes after treatment with fenofibric acid. The PPAR effect on ALT1 expression was shown to act through a direct transcriptional mechanism involving at least one PPAR response element (PPRE) in the proximal ALT1 promoter, while no effect of fenofibrate and AZD4619 was observed on the ALT2 promoter. Binding of PPARs to the PPRE located at - 574 bp from the transcriptional start site was confirmed on both synthetic oligonucleotides and DNA in hepatocytes. These data show that intracellular ALT expression is regulated by PPAR agonists and that this mechanism might contribute to increased ALT activity in serum

Rescue excavations on Alt-Laari settlement site, Tartumaa / Anti Lillak, Heiki Valk

Index Scriptorium Estoniae

Lillak, Anti

2009-01-01

Alt-Laari linnusasula tekkis nähtavasti rooma rauaajal. Kui Alt-Laari linnus oli kasutused arvatavasti I aastatuhandest II aastatuhandeni pKr. siis asula kestis edasi keskajal ning jäeti maha hiljemalt 14. sajandil

The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

Energy Technology Data Exchange (ETDEWEB)

Huang, Chenhui; Jia, Pingping; Chastain, Megan; Shiva, Olga; Chai, Weihang, E-mail: wchai@wsu.edu

2017-06-15

Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST) plays a multi-faceted role in telomere maintenance in telomerase-expressing cancer cells. However, the role of CST in telomere maintenance in ALT cells is unclear. Here, we report that human CST forms a functional complex localizing in the ALT-associated PML bodies (APBs) in ALT cells throughout the cell cycle. Suppression of CST induces telomere instabilities including telomere fragility and elevates telomeric DNA recombination, leading to telomere dysfunction. In addition, CST deficiency significantly diminishes the abundance of extrachromosomal circular telomere DNA known as C-circles and t-circles. Suppression of CST also results in multinucleation in ALT cells and impairs cell proliferation. Our findings imply that the CST complex plays an important role in regulating telomere maintenance in ALT cells. - Highlights: • CST localizes at telomeres and ALT-associated PML bodies in ALT cells throughout the cell cycle. • CST is important for promoting telomeric DNA replication in ALT cells. • CST deficiency decreases ECTR formation and increases T-SCE. • CST deficiency impairs ALT cell proliferation and results in multinucleation.

Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

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Eun Young Yu

2015-10-01

Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

Pattern of AST and ALT changes in Relation to Hemolysis in sickle cell Disease

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K. Nsiah

2011-01-01

Full Text Available Background Elevated aminotransferase levels are commonly associated with compromised hepatic integrity from various insults. In sickle cell disease, aspartate transaminase (AST is also released via intravascular hemolysis. This study was done to determine the pattern of changes in AST and alanine transaminase (ALT, in particular the AST:ALT ratio, and to relate these to the hemolytic state, which we consider to be more important than hepatic and cardiac dysfunction in some individuals with sickle cell disease. Methods Serum aminotransferase levels were measured in 330 subjects with sickle cell disease, as well as hemoglobin, reticulocytes, and lactate dehydrogenase. The AST:ALT ratio was designated as a hemolytic marker, and simple and multivariate regression analyses were carried out between this ratio and other hemolytic markers. Results Mean AST and ALT levels were 48.24 % 27.78 and 26.48 % 22.73 U/L, respectively. However, for 49 subjects without sickle cell disease, mean AST and ALT levels were the same, ie, 23.0 U/L. In the subjects with sickle cell disease, the increases in AST levels were far higher than for ALT, supporting its release via intravascular hemolysis. In 95.8% of the subjects with sickle cell disease, the AST:ALT ratio was > 1, but our results did not suggest overt malfunctioning of the liver and heart in the majority of subjects. Conclusion Regression analyses support the use of the AST:ALT ratio as a hemolytic marker, because it has an inverse association with the hemoglobin level. Whether in steady state or in crisis, provided hepatic and cardiac integrity has not been compromised, subjects with sickle cell disease would have higher AST levels due to the hemolytic nature of the condition. This is the first report highlighting the AST:ALT ratio in sickle cell disease.

ALT-I pump limiter results on TEXTOR

International Nuclear Information System (INIS)

Dippel, K.H.; Finken, K.H.; Guthrie, S.E.; Malinowski, M.E.; Pontau, A.E.; Campbell, G.A.; Goebel, D.M.; Conn, R.W.

1985-01-01

The ALT-I pump limiter is used to control hydrogen fluxes from the TEXTOR tokamak. The performance of two different modules, the open fixed geometry (FG) and the closed variable geometry (VG) is discussed. In unpumped scoop limiter operation, the pressure in the ALT-I chamber increases to 3x10 -4 torr(FG) and 2x10 -3 torr(VG). With pumping, the fraction of particles incident on the neutralizer plate that is removed is 25-50%(FG) and 50-80%(VG). These removed particles are estimated to be 2-4(8)%(FG) and 6-13%(VG) of the total plasma outflux (Nsub(e)/tausub(p)). The collection of helium from the plasma using the FG module is approximately half as effective as hydrogen collection. The higher particle removal efficiency for the VG module is attributed to lower neutral backstreaming. (author)

The most crabbed of all earthly music: the performance of Bach's vocal music in Dublin in the nineteenth and early twentieth centuries.

OpenAIRE

Boydell, Barra

2004-01-01

When the 'Crucifixus' from Bach's Mass in B minor was performed for the first time in Ireland, by the University of Dublin Choral Society in May 1865, the Dublin Daily Express described it as 'this most crabbed of all earthly music'.

ALT Blood Test: MedlinePlus Lab Test Information

Science.gov (United States)

... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Alanine Aminotransferase (ALT); p. 31. Lab ...

[Health and death of Wolfgang Amadeus Mozart].

Science.gov (United States)

Zegers, R H C

2002-12-21

Not much is known about the medical history and cause of death of the composer Wolfgang Amadeus Mozart (1756-1791). Contrary to popular opinion, Mozart was not an exceptionally ill child and as an adult he generally enjoyed good health. At the age of 9 years he experienced a life-threatening illness, which was probably typhoid fever. On the left-hand side he had what has since become known as 'Mozart's ear', a pinna with under-development of the anthelical fold. His psychological condition gives rise to the notion that he was not exceptional, but that he responded to the events in his life in a normal manner. His terminal illness was characterised by edema of hands and feet, without any associated dyspnoea being described. The medical treatment was aggressive: enema, bloodletting on several occasions and treatment with a laxative substance. He was burried in an anonymous grave. The skull that was later ascribed to him was not his own, as no element of the denture fits with the tooth abscess he was known to have experienced. An overdose of mercury during the treatment of syphilis seems to be unlikely, as equally Henoch-Schönlein-purpura and the consequences of acute rheumatism. Trichinosis is a recent hypothesis which fits the terminal symptoms and the fact that Mozart was fond of pork. The diagnosis of his physician Closset was 'hitsiges Frieselfieber', which was possibly caused by one of the many infectious diseases prevalent at that time.

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT Phenotype

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João P. Amorim

2016-09-01

Full Text Available Telomeres are responsible for protecting chromosome ends in order to prevent the loss of coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and can occur by upregulation of the telomerase enzyme or through a homologous recombination-associated process, the alternative lengthening of telomeres (ALT. The precise mechanisms that govern the activation of ALT or telomerase in tumor cells are not fully understood, although cellular origin may favor one of the other mechanisms that have been found thus far in mutual exclusivity. Specific mutational events influence ALT activation and maintenance: a unifying frequent feature of tumors that acquire this phenotype are the recurrent mutations of the Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX or Death-Domain Associated Protein (DAXX genes. This review summarizes the established criteria about this phenotype: its prevalence, theoretical molecular mechanisms and relation with ATRX, DAXX and other proteins (directly or indirectly interacting and resulting in the ALT phenotype.

ALT-II toroidal belt limiter biasing experiments on TEXTOR

International Nuclear Information System (INIS)

Doerner, R.; Boedo, J.A.; Gray, D.S.

1991-01-01

Edge electric fields have been related to H-mode-like behaviour. The experiments reported here are an attempt to control the SOL profiles by electrostatic biasing of the full toroidal-belt limiter ALT-II. The specific goals are: influencing the edge particle flows, particle removal, power deposition and the global confinement. The ALT-II pump limiter is a full toroidal belt located at 45 o below the outer midplane and consisting of eight graphite covered blades which can be independently biased. Particle scoops located behind the limiter neutralize and direct the incoming plasma into the pumping ducts. (author) 5 refs., 3 figs

Efectividad de la terapia floral de Bach en pacientes con alcoholismo crónico

OpenAIRE

Contrera Vega, Noraima; Cedeño Rodríguez, Enriqueta; Vázquez Sánchez, Monserrat

2012-01-01

Se realizó una intervención terapéutica en 15 pacientes con alcoholismo crónico, pertenecientes al Grupo Básico de Trabajo No. 3 del Policlínico Docente "Armando García Aspurú", de Santiago de Cuba, desde junio de 2008 hasta febrero de 2009, a fin de evaluar la efectividad de la terapia floral de Bach en el tratamiento de dichos pacientes, para lo cual se aplicó primero un esquema terapéutico general y luego individual. Se emplearon la media aritmética para cuantificar los datos, la desviació...

Influence of gender, BMI, and ethnicity on serum ALT levels of healthy students of a medical school

International Nuclear Information System (INIS)

Bilal, M.; Tariq, A.; Khan, S.; Quratulain, A.; Tariq, A.; Shahid, M.F.; Khan, M.W.; Naveed, A.K.

2011-01-01

Background: Alanine Aminotransferase (ALT) is an enzyme found in Liver and indicates injury to Hepatocytes. It is influenced by various factors. The objectives of this study were to identify the correlates of ALT activity among healthy medical students of Army Medical College, National University of Sciences and Technology, aged 18-22 years. This was to establish the mean ALT levels of the students and compare them with those in various parts of the world and observe various correlations that exist and factors that may influence ALT levels. Methods: This population included 143 volunteer students (93 men and 50 women) selected on the basis of negative answers to a detailed medical questionnaire including past medical history, drug and alcohol consumption, on the absence of clinical signs of liver disease, on the negativity of serological testing for Hepatitis B and C virus. Results: The mean ALT level of the entire population was 28.7 IU/L. A major sex-difference in ALT value was observed, the mean ALT value being higher in men than in women (32.1+- 21.7 vs. 22.6 +- 9.7 IU/L, p<0.004). According to WHO criteria for Asians, normal BMI was taken from 18.5-23.0 Kg/m/sup 2/. There was a positive significant correlation between serum ALT level and BMI (p<0.002). ALT level strongly correlates with body mass index and gender. There was no significant variation in ALT levels among Punjabis and Sindhis, Balochis, Pathans, and Kashmiris. Conclusion: We suggest the need of taking into account these parameters in a clinical interpretation of ALT level. (author)

Kui kapital veab alt, siis turvaliselt / Aleksander Tsapov

Index Scriptorium Estoniae

Tsapov, Aleksander

2006-01-01

Kuraatorinäitus "Kapital (see veab meid alt)" Tallinna Kunstihoones. Kuraator Simon Sheikh. Fia-Stina Sandlundi, Katya Sanderi, Oliver Ressleri, Ashley Hunti ja Susan Kelly&Stephen Mortoni töödest näitusel

Hans Werner Richter - Wolfgang Borchert : zwei Schriftsteller im 2. Weltkrieg ; ihre Kriegseinsätze und die Umsetzung in Literatur

OpenAIRE

Brandes, Katrein

2018-01-01

Hans Werner Richter und Wolfgang Borchert, zwei der bekanntesten deutschen Nachkriegsschriftsteller, waren selbst auf erbittert umkämpften Schauplätzen des 2. Weltkrieges eingesetzt: Richter in Italien bei Cassino, Borchert an der Ostfront südlich Moskaus. Trotz der Auseinandersetzung mit ihren literarischen Zeugnissen aus dieser Zeit, wie Richters Roman „Die Geschlagenen“ und Borcherts Kurzgeschichten, ist die Frage nach ihrem eigenen Kriegserleben, nach Schuldbewusstsein und dem Niederschla...

Aplicación de la terapia floral de Bach en niños con retardo del desarrollo psíquico

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María Elena Francia Reyes

2003-08-01

Full Text Available Se realizó un trabajo investigativo, prospectivo, transversal, con 100 alumnos de la Escuela Especial de Retardo del Desarrollo Psíquico "Turcios Lima", situada en el consejo popular de Cayo Hueso en el municipio Centro Habana, con el objetivo de evaluar los resultados de la aplicación de la terapia floral de Bach en el aprendizaje de estos niños diagnosticados como retardados. A principios del siglo xx el doctor Edward Bach (1886-1936, médico de origen galés, desarrollo un original y eficaz sistema de curación. Él sostuvo que la enfermedad es producto del desequilibrio entre la mente y el cuerpo, que altera el campo energético del ser vivo. El organismo se enferma ante el padecer psicológico y el desorden emocional, y expresó: "La enfermedad no es un mal a suprimir sino un beneficio a comprender." Se seleccionaron de forma aleatoria a 100 niños de dicha escuela, constituyéndose un grupo estudio y otro control. Se revisaron sus expedientes y se realizó historia clínica floral. Se realizaron entrevistas a padres y maestros para confrontar resultados. Se aplicaron remedios florales y se arribaron a conclusiones como que la aplicación de estos remedios facilita el tránsito de escuela especial a enseñanza general.At the beginning of the 20th century, a Welsh doctor named Edward Bach(1886-1936, developed an original and efficient healing system. He affirmed that the disease was the result of imbalance of the mind and the body that distorted the energy field of the live being. The body got sick due to psychological and emotional disorders, so he said "Disease is not an evil to be eliminated but a benefit to be understood." A prospective cross-sectional study of 100 students was conducted in "Turcios Lima" Special School for Psychical Development Retardation located in Cayo Hueso neighborhood, Centro Habana municipality. The objective was to evaluate the results of the application of Bach´s flower therapy in the learning process of

ALT-I pump limiter experiments

International Nuclear Information System (INIS)

Goebel, D.M.; Conn, R.W.; Campbell, G.A.

1987-09-01

Results from the ALT-I pump limiter experiments in TEXTOR are presented. ALT-I has demonstrated control of the plasma density in a high recycling tokamak by pumping up to 15% of the core efflux. The closed pump limiter designs with restricted entrance geometries to reduce the backflow of neutral gas to the plasma remove over 50% of the ion flux incident on the collection slot. Up to 80% of the entrance ion flux is removed when the edge electron temperature is less than 10 eV and plasma-neutral gas interactions are minimized inside the limiter. Results from a 3-D Monte Carlo neutral gas transport code agree closely with these experimental results. The compound curvature of the head is found to distribute the heat over the surface as predicted in the original designs. Impurity removal experiments demonstrate that significant helium exhaust can be achieved with a pump limiter. During ohmic heating in TEXTOR, the energy and particle confinement times are proportional to the line averaged core density. With ICRH auxiliary heating, tau/sub E/ follow L-mode scaling independent of particle removal by the pump limiter. Pump limiter operation does not directly modify the SOL plasma density and electron temperature, but controls the core plasma density by changing the global recycling at the boundary. The global particle confinement, the particle flux to the limiter, and the edge electron temperature follow the changes in the core density and auxiliary heating power. 25 refs

ALT Strategy, February 2017 - January 2020

OpenAIRE

Deepwell, Maren

2017-01-01

The Association for Learning Technology (ALT) represents individual and organisational Members from all sectors and parts of the UK. Our Membership includes practitioners, researchers and policy makers with an interest in Learning Technology. Our community grows more diverse as Learning Technology has become recognised as a fundamental part of learning, teaching and assessment. Our charitable objective is "to advance education through increasing, exploring and disseminating knowledge in t...

Fluvial sediment transport in a glacier-fed high-mountain river (Riffler Bach, Austrian Alps)

Science.gov (United States)

Morche, David; Weber, Martin; Faust, Matthias; Schuchardt, Anne; Baewert, Henning

2017-04-01

High-alpine environments are strongly affected by glacier retreat since the Little Ice Age (LIA). Due to ongoing climate change the hydrology of proglacial rivers is also influenced. It is expected that the growing proportions of snow melt and rainfall events will change runoff characteristics of proglacial rivers. Additionally, the importance of paraglacial sediment sources in recently deglaciating glacier forefields is increasing, while the role of glacial erosion is declining. Thus complex environmental conditions leading to a complex pattern of fluvial sediment transport in partly glaciated catchments of the European Alps. Under the umbrella of the joint PROSA-project the fluvial sediment transport of the river Riffler Bach (Kaunertal, Tyrol, Austria) was studied in 3 consecutive ablation seasons in order to quantify sediment yields. In June 2012 a probe for water level and an automatic water sampler (AWS) were installed at the outlet of the catchment (20km2). In order to calculate annual stage-discharge-relations by the rating-curve approach, discharge (Q) was repeatedly measured with current meters and by salt dilution. Concurrent to the discharge measurements bed load was collected using a portable Helley-Smith sampler. Bed load samples were weighted and sieved in the laboratory to gain annual bed load rating curves and grain size distributions. In total 564 (2012: 154, 2013: 209, 2014: 201) water samples were collected and subsequently filtered to quantify suspended sediment concentrations (SSC). Q-SSC-relations were calculated for single flood events due to the high variability of suspended sediment transport. The results show a high inter- and intra-annual variability of solid fluvial sediment transport, which can be explained by the characteristics of suspended sediment transport. Only 13 of 22 event-based Q-SSC-relations show causal dependency. In 2012, during a period with multiple pluvial-induced peak discharges most sediment was transported. On the

The Advanced Limiter Test-I (ALT-I) variable-geometry pump limiter module

International Nuclear Information System (INIS)

Pontau, A.E.; Malinowski, M.E.; Ver Berkmoes, A.A.; Guthrie, S.E.; Watson, R.D.; Goebel, D.M.; Campbell, G.A.

1984-01-01

The ALT-I variable geometry module has been designed to address many of the issues not previously settled by earlier experiments. The goal is to study the basic processes involved in pump limiter operation as well as demonstrate its utility and effect on the plasma. The flexibility and extensive instrumentation of ALT-I will offer a unique opportunity to parameterize operation and facilitate the engineering design of future pump limiters. (orig.)

Solutions of the linearized Bach-Einstein equation in the static spherically symmetric case

International Nuclear Information System (INIS)

Schmidt, H.J.

1985-01-01

The Bach-Einstein equation linearized around Minkowski space-time is completely solved. The set of solutions depends on three parameters; a two-parameter subset of it becomes asymptotically flat. In that region the gravitational potential is of the type phi = -m/r + epsilon exp (-r/l). Because of the different asymptotic behaviour of both terms, it became necessary to linearize also around the Schwarzschild solution phi = -m/r. The linearized equation resulting in this case is discussed using qualitative methods. The result is that for m = 2l phi = -m/r + epsilon r -2 exp (-r/l) u, where u is some bounded function; m is arbitrary and epsilon again small. Further, the relation between the solution of the linearized and the full equation is discussed. (author)

Neurosurgery and Music; Effect of Wolfgang Amadeus Mozart.

Science.gov (United States)

Gasenzer, Elena Romana; Kanat, Ayhan; Neugebauer, Edmund

2017-06-01

The nervous system works like a great orchestra. Specifically, the music of Mozart with its "Mozart effect" is appropriate to use in neurosurgery. We investigated the relationship between Mozart's music and neurosurgery. We used digital catalogs like "PubMed" and the libraries of universities. Key words were "Wolfgang Amadeus Mozart" and "neurosurgery and music." In the first half of the 20th century, performing neurosurgery on some musicians, such as Maurice Ravel, Josef Hassid, and George Gershwin, resulted in a fatal outcome. The cause of this is probably that neurosurgery had not been developed yet in the first half of the 20th century. In the past 3 decades, the neurosurgical operations of musicians show that musicians have rich associations among auditory, somatic, and sensorial systems. It is clear that we have much to learn from studies about music and brain function that derive from our surgical experiences with patients. The neuronal plasticity of musicians' brains may be different from that of nonmusicians' brains. Musicians with enhanced motor skills have greater capacity for plasticity because of enriched interhemispheric connections. Listening to music and the effect of Mozart in neurosurgical practice, intensive care, or rehabilitation were documented in many studies. As authors, we mean something different: Its effectiveness should be studied. We concluded that in current neurosurgical practice, Mozart has an effect. More research and clinical studies are needed. Copyright © 2017 Elsevier Inc. All rights reserved.

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.

Science.gov (United States)

Jeyapalan, Jennie N; Mendez-Bermudez, Aaron; Zaffaroni, Nadia; Dubrova, Yuri E; Royle, Nicola J

2008-06-01

Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-tissue sarcoma in adults and they activate ALT or telomerase with equal frequency, however no TMM has been identified in approximately 50% of liposarcomas. In our study, we have shown that instability at the minisatellite MS32, usually associated with ALT activation, aids the identification of liposarcomas that have recombination-like activity at telomeres in absence of ALT associated PML-bodies (APBs). Furthermore, using single molecule telomere analysis, we have detected complex telomere mutations directly in ALT positive liposarcomas and interestingly in some liposarcomas with an unknown TMM but high MS32 instability. We have shown by sequence analysis that some of these complex telomere mutations must arise by an inter-molecular recombination-like process rather than by deletion caused by t-loop excision or by unequal telomere-sister-chromatid-exchange (T-SCE), which is known to be elevated in ALT cell lines. Preliminary evidence also suggests that inter-molecular recombination events may be processed differently in liposarcomas with APBs compared to those without. In conclusion, we have shown for the first time, that some telomerase negative liposarcomas without APBs have other features associated with ALT, indicating that the incidence of ALT in these tumours has previously been under-estimated. This has major implications for the use of cancer treatments targeted at TMMs. (c) 2008 Wiley-Liss, Inc.

Conference on Inequalities and Applications : Dedicated to the Memory of Wolfgang Walter

CERN Document Server

Gilányi, Attila; Losonczi, László; Plum, Michael

2012-01-01

Inequalities arise as an essential component in various mathematical areas. Besides forming a highly important collection of tools, e.g. for proving analytic or stochastic theorems or for deriving error estimates in numerical mathematics, they constitute a challenging research field of their own. Inequalities also appear directly in mathematical models for applications in science, engineering, and economics. This edited volume covers divers aspects of this fascinating field. It addresses classical inequalities related to means or to convexity as well as inequalities arising in the field of ordinary and partial differential equations, like Sobolev or Hardy-type inequalities, and inequalities occurring in geometrical contexts. Within the last five decades, the late Wolfgang Walter has made great contributions to the field of inequalities. His book on differential and integral inequalities was a real breakthrough in the 1970’s and has generated a vast variety of further research in this field. He also organize...

Presentation and demonstration at Alt-i-lab 2005

NARCIS (Netherlands)

Tattersall, Colin

2005-01-01

These documents were used to accompany the Learning Design presentation and demonstration at Alt-i-lab 2005. The slides were shown during a plenary session describing the interoperability demo. The scenario was used to guide the demonstration process, and the UNFOLD handout was used to illustrate

Numerical analysis of the flow around the Bach-type Savonius wind turbine

International Nuclear Information System (INIS)

Kacprzak, K; Sobczak, K

2014-01-01

The performance of the Bach-type Savonius wind turbine with a constant cross-section is examined by means of quasi 2D and 3D flow predictions obtained from ANSYS CFX. Simulations were performed in a way allowing for a comparison with the wind tunnel data presented by Kamoji et al. The comparison with the experiment has revealed that 2D solutions give much higher deviation from the reference data than the 3D ones, which guarantees a good solution quality. It can be stated that even simplified (lack of laminar-turbulence transition modelling and a coarser mesh) 3D simulations can yield more accurate results than complex 2D solutions for turbines with a low aspect ratio. The paper also presents a systematic analysis of the most characteristic flow structures which are identified in the rotor.

Numerical analysis of the flow around the Bach-type Savonius wind turbine

Science.gov (United States)

Kacprzak, K.; Sobczak, K.

2014-08-01

The performance of the Bach-type Savonius wind turbine with a constant cross-section is examined by means of quasi 2D and 3D flow predictions obtained from ANSYS CFX. Simulations were performed in a way allowing for a comparison with the wind tunnel data presented by Kamoji et al. The comparison with the experiment has revealed that 2D solutions give much higher deviation from the reference data than the 3D ones, which guarantees a good solution quality. It can be stated that even simplified (lack of laminar-turbulence transition modelling and a coarser mesh) 3D simulations can yield more accurate results than complex 2D solutions for turbines with a low aspect ratio. The paper also presents a systematic analysis of the most characteristic flow structures which are identified in the rotor.

Preparatory investigations for a public dialogue on flash flood risk in the Mehlemer Bach catchment, Germany

Science.gov (United States)

Seydel, Elena; Turley, Michael; Becht, Michael; Heckmann, Tobias

2013-04-01

On July 3rd, 2010, an extreme precipitation event occurred in the municipality of Wachtberg at the southern urban fringe of the Federal City of Bonn. The 30-min intensity of the torrential rain was estimated to represent a 1000 year event according to the KOSTRA dataset (German Meteorological Service, DWD). Rapid overland flow and the exceedance of the design values of the sewerage system caused a flash flood in the Mehlemer Bach catchment. Roughly 400 buildings were affected in its lower, urbanized part, and it took over two weeks to clear the damage. Similar flash flood events have been recorded in the same catchment regularly since the year 1693, three times in the last 80 years alone. The fact that, in case of the 2010 event, the official weather warning was released almost simultaneously to the beginning of the downpour highlights the urgent need for preparative action in the longer term. Flash flood risk mitigation relies, among others, on risk awareness and preparedness of residents. One aim of this study is to analyse the current risk communication in the drainage area of Mehlemer Bach through questionnaires and expert interviews, which will provide a good basis for an open dialogue between residents and the authorities. There is an urgent need for practical and accessible advice, and it must be ensured that the resources and capabilities of the individuals involved are taken into consideration. In addition, we compare a hazard map of the area to mental maps drawn by the local population in order to assess their risk perception.

The results of treatment for thyrotoxicosis at Bach Mai hospital

International Nuclear Information System (INIS)

Phan Sy An

2002-01-01

The authors evaluated the results of treating hyperthyroidism with 131 I. Patient selection for tre treatment is based on clinical features and laboratory test results such as thyroid uptake, scintigraphy and RIA determinations of thyroid hormones. The average dose is 6.2±1.1 m Ci (that is 233.1±40.7 MBq). The average number of doses is 1.3 for one patient. The results are as follows: - Euthyroid status after 4 years follow-up from the 1 31 I dose administration: 72.3 - Persistent or recurrent hyperthyroidism: 20 %. - Hypothyroid complication appears 6 years after the administration of 1 31 I dose: 14 %. So the cumulative hypothyroid rate is: 2.3 % per year. - Serious complications were not observed in any patient. Hyperthyroidism is a common health problem in Vietnam (1). In the past, only antithyroid drugs and surgery were used. 131 I was first introduced to Vietnam in the Nuclear Medicine Department in Bach Mai in 1971 and thereafter widely applied in the country. (Author)

Disney explains Bach: a pedagogic unit on the Fifth Brandenburg Concerto

Directory of Open Access Journals (Sweden)

Giorgio Pagannone

2014-12-01

Full Text Available This article illustrates a pedagogic unit on music listening that is centered on the first movement of the Fifth Brandenburg Concerto by Bach and is aimed at primary school pupils. The selected concert is of historical importance for the prominent role assumed by the harpsichord in comparison to the other two soloists (flute and violin. The didactic “bridge” that is useful to deal with this piece and carve out the cognitive contents ad hoc has been identified by Giorgio Pagannone in Walt Disney’s animated cartoon, Three Little Pigs (1933, based on a fairy tale of the same name.First, we present and analyse  the music piece and animated cartoon. Next, we provide a detailed and articulated description of the pedagogic unit, that was adopted by Silvia Cancedda in a primary school in Bologna (Italy and produced very good results such as the intuitive reading of selected score fragments. The appendix includes some of the works done by the pupils.

The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.

Science.gov (United States)

Sumida, Yoshio; Yoshikawa, Toshikazu; Tanaka, Saiyu; Taketani, Hiroyoshi; Kanemasa, Kazuyuki; Nishimura, Tekeshi; Yamaguchi, Kanji; Mitsuyoshi, Hironori; Yasui, Kohichiroh; Minami, Masahito; Naito, Yuji; Itoh, Yoshito

2014-12-01

Physicians often experience difficulties in motivating patients with non-alcoholic fatty liver disease (NAFLD) to undergo lifestyle changes. The aim of this study is to examine whether 'Donations for Decreased alanine aminotransferase (ALT)' (D4D) prosocial behavior incentive can serve as an effective intrinsic motivational factor in comparison with conventional dietary and exercise intervention alone for NAFLD patients. Twenty-five NAFLD patients with elevated ALT were randomly assigned to a control group that received conventional dietary and exercise intervention alone, or a donation group whereby, as an incentive, we would make a monetary donation to the United Nations World Food Programme (WFP) based on the decrease in their ALT levels achieved over 12 weeks, in addition to receiving control intervention. In a donation group, we would donate US$1 to the WFP for every 1 IU/l of decrease in their ALT levels. There were no differences of pre-treatment clinical characteristics between the two groups. Significant reductions of ALT levels were achieved only in a donation group, although post-treatment ALT levels were not different between the two groups. These patients raised a total of $316 for the WFP. Promoting patients' intrinsic motivation by incorporating 'D4D' prosocial behavior incentive into conventional dietary and exercise intervention may provide a means to improve NAFLD. © The Author 2013. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Die Altäre von Selinunt

OpenAIRE

Voigts, Clemens

2014-01-01

In der Dissertation wurden die Altäre von Selinunt, einer griechischen Kolonie auf Sizilien, mit den Methoden der Bauforschung untersucht. Die neun behandelten Brandopferaltäre sind monumentale Quaderbauten, die bis zu 20 m Länge erreichen. Sie stammen aus der Blütezeit Selinunts, dem 6. und 5. Jh. v. Chr. Die Bauten waren bereits im 19. und 20. Jh. freigelegt worden und wurden nun in Bauaufnahmen dokumentiert, zeichnerisch rekonstruiert und zeitlich eingeordnet. Dabei ließ sich an ihnen eine...

Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

Science.gov (United States)

Ahn, Song Vogue; Baik, Soon Koo; Cho, Youn zoo; Koh, Sang Baek; Huh, Ji Hye; Chang, Yoosoo; Sung, Ki-Chul; Kim, Jang Young

2016-01-01

Aims The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study. Material and Methods The population-based cohort study included 2276 adults (903 men and 1373 women) aged 40–70 years, who participated from 2005–2008 (baseline) without metabolic syndrome and were followed up from 2008–2011. Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Serum concentrations of AST and ALT were determined by enzymatic methods. Results During an average follow-up period of 2.6-years, 395 individuals (17.4%) developed metabolic syndrome. In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422–0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of metabolic syndrome (0.715 vs. 0.732, P = 0.004). The net reclassification improvement of prediction models including the AST-to-ALT ratio was 0.23 (95% CI: 0.124–0.337, Pmetabolic syndrome and had incremental predictive value for incident metabolic syndrome. PMID:27560931

Langmuir probe measurements in the TEXTOR tokamak during ALT-I pump limiter experiments

International Nuclear Information System (INIS)

Goebel, D.M.; Campbell, G.A.; Conn, R.W.; Leung, W.K.; Dippel, K.H.; Finken, K.H.; Thomas, G.J.; Pontau, A.E.

1986-04-01

Langmuir probes have been used to characterize the edge plasma of the TEXTOR tokamak and measure the parameters of the plasma incident on the ALT-I pump limiter during ohmic and ICRH heating. Probes mounted directly on the ALT limiter, and a scanning probe located 90 0 toroidally from the limiter, provide data for the evaluation of pump limiter performance and its effect on the edge plasma. The edge plasma is characterized by density and flux e-folding lengths of about 1.8cm when ALT is the main limiter. These scrape-off lengths do not vary significantly as ALT is moved between the normal 42-46cm minor radii, but increase to over 2.2cm when ALT is inserted to 40cm. The flux to probes at a fixed position in the limiter shadow varies by less than 25% for core density changes of a factor of five. This suggests that the global particle confinement time tau/sub p/, scales as the core density. Estimates from the probes indicate that tau/sub p/ is on the order of the energy confinement time, tau/sub E/. The edge electron temperature, T/sub e/, typically decreases by a factor of two when the core density is raised from 1 to 4 x 10 13 cm -3 . The T/sub e/ profile is essentially flat in the limiter shadow, with values of 10-25 eV depending on the core plasma density and ICRH power. ICRH heating increases the electron temperature and flux in proportion to the coupled power. With ALT as the primary limiter and no direct shadowing, the ion side receives 2 to 3 times the flux of the electron side during both ohmic and ICRH heating. The edge plasma is not directly modified by pump limiter operation, but changes with the core plasma density as particle removal lowers the recycling of neutrals in the boundary

Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals

DEFF Research Database (Denmark)

Sabin, Caroline A; Ryom, Lene; Kovari, Helen

2013-01-01

An inverse association between serum alanine aminotransferase (ALT) levels and the risk of myocardial infarction (MI) has been reported in the general population. We investigated associations between ALT levels and the risk of various cardiovascular and cerebrovascular outcomes in a large cohort ...

Measurement and purification of Alanine aminotransferase (ALT enzyme activity in patients with celiac disease

Directory of Open Access Journals (Sweden)

Taghreed U. Mohammed

2017-09-01

Full Text Available Celiac disease (CD is the most common genetically - based disease in correlation with food intolerance. The aim of this study is to measure the activity of ALT enzyme and purify enzyme from sera women with celiac disease. Alanine aminotransferase (ALT activity has been assayed in (30 women serum samples with celiac disease, age range between (20-40 year and (30 serum of healthy women as control group, age range between (22-38 year. In the present study, the mean value of ALT activity was significantly higher in patients with celiac disease than healthy group (p<0.01. The ALT enzyme was partial purified from sera women with celiac disease by dialysis, gel filtration using Sephadex G- 50 and ion exchange chromatography using DEAE- cellulose A-50 . The results showed a single peak by using gel filtration and the activity reached 31-15 U/L .Two isoenzymes were obtained by using ion exchange chromatography and the purity degree of isoenzymse (I, II were (5.7 and (5.53 fold respectively

Genel Anestezi Altında Çocukta Diş Tedavisi

OpenAIRE

Gülhan, A.; Sandallı, N.

2013-01-01

ÖZETBu makalede çocuklarda genel anestezi altında diş tedavisinin koşulları anlatıldı ve normal tedavi koşulları sağlanamadığı takdirde, genel anesteziye başvurmanın yararlarına ve sakıncalarına değinildi. Genel anestezi indikasyonları sıralanarak, bunlar arasında en sık rastladığımız «Güç çocuklarım" genci anesteziye başvurmadan Önce hangi yollara başvurularak normal tedavinin deneneceğinden bahsedildi.Bir hastane ortamında genel anestezi altında çalışmaya karar verildikten sonra, bir a...

Peek ja Lepik soovisid varade aresti alt vabastamist

Index Scriptorium Estoniae

2005-01-01

LHV endine töötaja Oliver Peek väidab, et tema vastu esitatud süüdistused on alusetud ja tõendamata ning nõuab oma varade aresti alt vabastamist. Kristjan Lepingu kohtuasja arutamine lükati edasi 21. detsembrile. Endiselt käib uurimine, kui palju väidetavalt teabevargusega raha teeniti

Correlation between Aminotransferase Ratio (AST/ALT and Other Biochemical Parameters in Chronic Liver Disease of Viral Origin

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Shah Md Fazlul Karim

2015-03-01

Full Text Available Background: In recent years the ratio of aspartate aminotransferase (AST to alanine aminotransferase (ALT in patients of chronic liver disease (CLD of various origins has gained much attention. This variable is readily available, easy to interpret, and inexpensive and the clinical utility of the AST/ALT ratio in the diagnostic workup of patients with CLD is quite promising. Objective: The present study was designed to find out the link between aminotransferase (AST/ALT ratio with commonly measured biochemical parameters of liver function tests in CLD of viral origin. Materials and method: This cross sectional study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka, Bangladesh. Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. With aseptic precaution 5 mL venous blood was collected from each subject and common liver function tests (serum AST, ALT, AST/ALT ratio, alkaline phosphatase, total bilirubin, serum total protein, serum albumin, serum globulin, serum albumin/globulin ratio, prothrombin time and viral serology (HBsAg, Anti HDV antibody, Anti HCV antibody were performed. Data were analyzed by SPSS version 19 for Windows. Pearson’s correlation test was done to determine association between AST/ALT with other biochemical parameters. Results: Mean(±SD age of the study subjects was 32.55±10.55 years (range 20-50 years with 48 (77.7% male and 14 (22.6% female subjects. Pearson’s correlation test was done between AST to ALT ratio with other biochemical parameters and prothrombin time showed significant positive correlation (p <0.01. Conclusion: In our study we found significant positive correlation between AST/ALT with prothrombin time in CLD subjects without cirrhosis.

A statistical physics view of pitch fluctuations in the classical music from Bach to Chopin: evidence for scaling.

Science.gov (United States)

Liu, Lu; Wei, Jianrong; Zhang, Huishu; Xin, Jianhong; Huang, Jiping

2013-01-01

Because classical music has greatly affected our life and culture in its long history, it has attracted extensive attention from researchers to understand laws behind it. Based on statistical physics, here we use a different method to investigate classical music, namely, by analyzing cumulative distribution functions (CDFs) and autocorrelation functions of pitch fluctuations in compositions. We analyze 1,876 compositions of five representative classical music composers across 164 years from Bach, to Mozart, to Beethoven, to Mendelsohn, and to Chopin. We report that the biggest pitch fluctuations of a composer gradually increase as time evolves from Bach time to Mendelsohn/Chopin time. In particular, for the compositions of a composer, the positive and negative tails of a CDF of pitch fluctuations are distributed not only in power laws (with the scale-free property), but also in symmetry (namely, the probability of a treble following a bass and that of a bass following a treble are basically the same for each composer). The power-law exponent decreases as time elapses. Further, we also calculate the autocorrelation function of the pitch fluctuation. The autocorrelation function shows a power-law distribution for each composer. Especially, the power-law exponents vary with the composers, indicating their different levels of long-range correlation of notes. This work not only suggests a way to understand and develop music from a viewpoint of statistical physics, but also enriches the realm of traditional statistical physics by analyzing music.

A statistical physics view of pitch fluctuations in the classical music from Bach to Chopin: evidence for scaling.

Directory of Open Access Journals (Sweden)

Lu Liu

Full Text Available Because classical music has greatly affected our life and culture in its long history, it has attracted extensive attention from researchers to understand laws behind it. Based on statistical physics, here we use a different method to investigate classical music, namely, by analyzing cumulative distribution functions (CDFs and autocorrelation functions of pitch fluctuations in compositions. We analyze 1,876 compositions of five representative classical music composers across 164 years from Bach, to Mozart, to Beethoven, to Mendelsohn, and to Chopin. We report that the biggest pitch fluctuations of a composer gradually increase as time evolves from Bach time to Mendelsohn/Chopin time. In particular, for the compositions of a composer, the positive and negative tails of a CDF of pitch fluctuations are distributed not only in power laws (with the scale-free property, but also in symmetry (namely, the probability of a treble following a bass and that of a bass following a treble are basically the same for each composer. The power-law exponent decreases as time elapses. Further, we also calculate the autocorrelation function of the pitch fluctuation. The autocorrelation function shows a power-law distribution for each composer. Especially, the power-law exponents vary with the composers, indicating their different levels of long-range correlation of notes. This work not only suggests a way to understand and develop music from a viewpoint of statistical physics, but also enriches the realm of traditional statistical physics by analyzing music.

Two in one or one in two? Pushing off from Jung with Wolfgang Giegerich.

Science.gov (United States)

Saban, Mark

2015-11-01

This paper responds to a recent paper by Wolfgang Giegerich entitled 'Two Jungs: apropos a paper by Mark Saban'. Giegerich disputes my assertion that the 'rigorous notion' at the heart of his psychology 'finds no source in Jung's psychology, implicit or explicit'. In order to do this he posits the existence of two Jungs, an exoteric Jung and an esoteric Jung. The implications of Giegerich's binary scission of Jung are explored in this paper, and show that the tendency to exalt one Jung while disparaging the other betrays a comprehensive blindness toward the contradictory complexity of Jung's psychology as a whole. It is suggested that this blindness is the consequence of Giegerich's systematic prioritization of a neo-Hegelian agenda that is in profound conflict with the telos of Jung's psychology. © 2015, The Society of Analytical Psychology.

The large eyes of Wolfgang Amadeus Mozart. (On the occasion of the 250th Mozart anniversary year).

Science.gov (United States)

Zegers, Richard H C; Saeed, Peerooz; Wiersinga, Wilmar M

2005-12-01

This article discusses the eyes of Wolfgang Amadeus Mozart (1756-1791) which, based on portraits, can be said to have a certain noticeable feature--some degree of exophthalmos. In fact, even contemporary observers made particular mention of Mozart's eyes being large. Although cicatricial ectropion, caused by infectious disease, cannot be excluded, mild myopia, in combination with shallow orbits or combined with a genetic predilection, would be one possible explanation for Mozart's large eyes. Graves' orbitopathy, the ophthalmic manifestation of hyperthyroidism, or hypothyroidism have both been suggested to be the cause of Mozart's large eyes. However, these diseases are unlikely causes given their topical and systemic features.

Republication of: New solutions to Einstein's equations of gravitation. B. Explicit determination of static, axially symmetric fields. By Rudolf Bach. With a supplement on the static two-body problem. By H. Weyl.

Science.gov (United States)

Bach, Rudolf; Weyl, Hermann

2012-03-01

This is the English translation of the third of a series of 3 papers by Hermann Weyl (the third one jointly with Rudolf Bach), first published in 1917-1922, in which the authors derived and discussed the now-famous Weyl two-body static axially symmetric vacuum solution of Einstein's equations. The English translations of the other two papers are published alongside this one. The papers have been selected by the Editors of General Relativity and Gravitation for re-publication in the Golden Oldies series of the journal. This republication is accompanied by an editorial note written by Gernot Neugebauer, David Petroff and Bahram Mashhoon, and by a brief biography of R. Bach, written by H. Goenner.

Keith Haring, Felix Gonzalez-Torres, Wolfgang Tillmans, and the AIDS Epidemic: The Use of Visual Art in a Health Humanities Course.

Science.gov (United States)

Smith, Jason A

2018-02-23

Contemporary art can be a powerful pedagogical tool in the health humanities. Students in an undergraduate course in the health humanities explore the subjective experience of illness and develop their empathy by studying three artists in the context of the AIDS epidemic: Keith Haring, Felix Gonzalez-Torres, and Wolfgang Tillmans. Using assignments based in narrative pedagogy, students expand their empathic response to pain and suffering. The role of visual art in health humanities pedagogy is discussed.

Wolfgang Geiger (17 July 1921 - 3 July 2000

Directory of Open Access Journals (Sweden)

Renata Boucher-Rodoni

2000-08-01

Full Text Available Wolfgang Geiger died on the 3rd July 2000, at the age of 79. He was born on July 17th 1921 in Biel; his mother died at his birth. His childhood was spent with his father, a well-known artist, partly in Ligerz, on Lake Biel, and partly in Porto Ronco in Ticino, on Lago Maggiore. After high school in Biel, he began his University studies, first at the Swiss Federal Institute of Technology in Zürich, then in Basel, where he studied under Professor A. Portmann. During his PhD a grant from the Janggen-Pöhn foundation enabled him to work for some months at the Institut des Pêches maritimes du Maroc, in Casablanca, with Dr. J .Furnestin. In 1953 he completed his PhD on teleost fish brain. His career as a biologist began in Bern at the Eidgenossische Inspektion für Fortwesen, Jagd und Fischerei. In 1962 he was appointed head assistant (chef des travaux at the University of Geneva, in the comparative anatomy and physiology laboratory (Dr H. J. Huggel, where he discovered the joys and the limitations of teaching. He was highly regarded as a lecturer and taught in a relaxed atmosphere of mutual respect and trust, much appreciated by his students. Professor Geiger was also the main organiser of field trips to Sète, on the French Mediterranean coast, where he was in his element living on the water. He went out on the trawlers with the students and introduced them enthusiastically to the marvels of sea fauna. He was happy during those field trips and had the knack of communicating his happiness to the students.

An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values.

Science.gov (United States)

Kliethermes, S; Ma, M; Purtell, C; Balasubramanian, N; Gonzalez, B; Layden, T J; Cotler, S J

2017-10-01

Childhood obesity is a risk factor for non-alcoholic fatty liver disease and poses important public health issues for children. Racial differences in alanine aminotransferase (ALT) levels among children have not been described. This study aimed to identify racial differences in upper limit normal (ULN) ALT levels and evaluate the effect of obesity on elevated levels in children without other metabolic risk factors. National Health and Nutrition Examination Surveys and clinical data from the Loyola University Health System were used to determine ULN ALT by race and gender. Quantile regression was used to evaluate the impact of obesity on elevated ALT and to identify potential risk factors for ALT above the ULN. Upper limit normal (ULN) ALT was approximately 28.0 and 21.0-24.0 U/L for boys and girls, respectively. No significant difference in ULN ALT across race was observed. Obesity was significantly associated with elevated ALT; obese children with elevated ALT had values 10 U/L higher than normal-weight children. Racial differences in ALT levels among adults are not evident in children. Obesity, in the absence of metabolic risk factors and other causes of liver disease, is associated with elevated ALT, providing evidence against the concept of healthy obesity in children. © 2016 World Obesity Federation.

Environmental Stress Induces Trinucleotide Repeat Mutagenesis in Human Cells by Alt-Nonhomologous End Joining Repair.

Science.gov (United States)

Chatterjee, Nimrat; Lin, Yunfu; Yotnda, Patricia; Wilson, John H

2016-07-31

Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rereplication, with more than 50% of mutants carrying deletions or insertions-molecular signatures of DNA double-strand break repair. We now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, LIG3, and PARP1-suppresses stress-induced TNR mutagenesis, in contrast to the components of homologous recombination and NHEJ, which have no effect. Thus, alt-NHEJ, which contributes to genetic mutability in cancer cells, also plays a novel role in environmental stress-induced TNR mutagenesis. Published by Elsevier Ltd.

Liver stiffness becomes stable in patients with chronic hepatitis C three months after ALT normalization due to antiviral therapy

Directory of Open Access Journals (Sweden)

CHEN Feikai

2013-10-01

Full Text Available ObjectiveTo investigate the time for liver stiffness measurement (LSM to become stable in chronic hepatitis C (CHC patients with elevated alanine aminotransferase (ALT levels after ALT normalization due to antiviral therapy. MethodsCHC patients who sought initial treatment at Peking University People′s Hospital were screened for elevated ALT levels from May 2011. Liver stiffness was determined by FibroScan. A total of 29 patients had been included in the study by September 2012, who were followed up regularly after antiviral treatment. ALT tests were repeated every four weeks and LSM every eight weeks until their medians did not change significantly. Comparisons of matched data at two adjacent time points were made with the non-parametric Wilcoxon test, while multiple comparisons of repeated measurements were performed using Bonferroni correction. Correlation between two variables was analyzed with the Spearman rank test. ResultsPatients were followed up until 24 weeks after antiviral treatment, and 24 patients were included in analysis. The median ALT levels were 64, 26, 21, 20, and 22 U/L at baseline and 4, 8, 12, and 24 weeks, respectively (P= 0.000, 0.006, 0.337, and 0.109 for comparisons between two adjacent values. ALT decreased significantly below 1 ULN at 4 weeks after antiviral therapy and stabilized at 8 weeks. The median LSM values were 8.7, 7.8, 6.8, and 6.7 kPa at baseline and 8, 16, and 24 weeks, respectively (P= 0.009, 0.001, and 0188 for comparisons between two adjacent values. LSM decreased significantly within 16 weeks after antiviral therapy and stabilized afterwards. LSM stabilized 12 weeks after ALT normalization. ConclusionLSM becomes stable in CHC patients with elevated ALT levels three months after ALT normalization due to antiviral therapy.

The medical laboratory issues about recommendation on uniform cutoff values of “normal” ALT in the ACG guidelines

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YU Qian

2018-01-01

Full Text Available In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology (ACG recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these “normal” cutoffs should be further investigated. Considering the differences between laboratory assays measuring ALT in our country, the standardization of methods and the consistency of results can not be completely ensured. The uniform “normal” range of ALT recommended by the ACG guidelines is largely based on findings from foreign studies and may not be suitable to Chinese population. On the other hand, reference upper/lower limits should not simply be equated with clinical decision thresholds. However, due to improper application of the related concepts of the above medical laboratory issues, simply recommending the uniform reference range of the ALT may lead to overdiagnosis and unnecessary follow-up examinations.

Effect of Ramadan fasting on alanine transferase (ALT in nonalcoholic fatty liver disease (NAFLD

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Hojjatolah Rahimi

2017-09-01

Full Text Available Background: The effects of Ramadan fasting on NAFLD are unknown and there are very limited studies have done in this area. Some nutritional and behavioral changes of fasting people in Ramadan can affect NAFLD. These include nutrition with high fat and calories, altering in weight and sleep and low physical activity. We decided to evaluate the effects of these changes on one of the important indicators of deterioration of NAFLD, ALT.Methods: Sixty patients with fatty liver disease performed two consecutive ALT exams before and after Ramadan month of whom finally 34 were fasting and 26 nonfasting. After collecting data they were divided in two groups of fasting and nonfasting and compared using SPSS software.Results: Mean ALT change from before to after Ramadan was higher and positive in fasting (+7.38±8.47 IU/L compared to nonfastng patients that was negative (-0.12±10.15 IU/L (P=0.002 and this change was mainly in patients who had fasted 21-30 days.Conclusion: Ramadan fasting may increase ALT. It is needed to perform more studies in patients with NAFLD during Ramadan fasting with larger sample size and in various conditions especially weight loss with patients’ education for observing dietary regimen.

Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women.

Science.gov (United States)

Sangfelt, Per; Von Sydow, Madeleine; Uhnoo, Ingrid; Weiland, Ola; Lindh, Gudrun; Fischler, Björn; Lindgren, Susanne; Reichard, Olle

2004-01-01

In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned.

Alt a 1 allergen homologs from Alternaria and related taxa: analysis of phylogenetic content and secondary structure.

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Hong, Soon Gyu; Cramer, Robert A; Lawrence, Christopher B; Pryor, Barry M

2005-02-01

A gene for the Alternaria major allergen, Alt a 1, was amplified from 52 species of Alternaria and related genera, and sequence information was used for phylogenetic study. Alt a 1 gene sequences evolved 3.8 times faster and contained 3.5 times more parsimony-informative sites than glyceraldehyde-3-phosphate dehydrogenase (gpd) sequences. Analyses of Alt a 1 gene and gpd exon sequences strongly supported grouping of Alternaria spp. and related taxa into several species-groups described in previous studies, especially the infectoria, alternata, porri, brassicicola, and radicina species-groups and the Embellisia group. The sonchi species-group was newly suggested in this study. Monophyly of the Nimbya group was moderately supported, and monophyly of the Ulocladium group was weakly supported. Relationships among species-groups and among closely related species of the same species-group were not fully resolved. However, higher resolution could be obtained using Alt a 1 sequences or a combined dataset than using gpd sequences alone. Despite high levels of variation in amino acid sequences, results of in silico prediction of protein secondary structure for Alt a 1 demonstrated a high degree of structural similarity for most of the species suggesting a conservation of function.

The death of Wolfgang Amadeus Mozart: an epidemiologic perspective.

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Zegers, Richard H C; Weigl, Andreas; Steptoe, Andrew

2009-08-18

The early death of the composer Wolfgang Amadeus Mozart on 5 December 1791 has fascinated the world for more than 2 centuries. It has been suggested that his final illness was caused by poisoning, renal failure, Henoch-Schönlein purpura, trichinosis, and many other conditions. The official daily register of deaths in Mozart's Vienna was evaluated to provide an epidemiologic framework into which the observations of contemporary witnesses of his death can be integrated. All recorded deaths in Vienna during November and December 1791 and January 1792 were analyzed, together with the corresponding periods in 1790 to 1791 and 1792 to 1793. The deaths of 5011 adults (3442 men, 1569 women) were recorded over these periods. The mean ages of death were 45.5 years (SD, 18.5) for men and 54.5 years (SD, 19.9) for women. Tuberculosis and related conditions accounted for the highest number of deaths; cachexia and malnutrition ranked second, and edema was the third most common cause. According to eyewitness accounts, the hallmark of Mozart's final disease was severe edema. Deaths from edema were markedly increased among younger men in the weeks surrounding Mozart's death compared with the previous and following years. This minor epidemic may have originated in the military hospital. Our analysis is consistent with Mozart's last illness and death being due to a streptococcal infection leading to an acute nephritic syndrome caused by poststreptococcal glomerulonephritis. Scarlet fever, which represents the same underlying disease from an etiologic perspective, is a less likely possibility.

Mutational analysis of the activator of late transcription, Alt , in the lactococcal bacteriophage TP901-1

DEFF Research Database (Denmark)

Pedersen, Margit; Hammer, Karin

2007-01-01

An activator protein, Alt, synthesized during the early state of lytic infection is required for transcription of the late operon in the lactococcal phage TP901-1. In order to identify amino acid residues in the Alt protein required for activation of the TP901-1 late promoter, Plate, hydroxylamine...

[Impact analysis of shuxuetong injection on abnormal changes of ALT based on generalized boosted models propensity score weighting].

Science.gov (United States)

Yang, Wei; Yi, Dan-Hui; Xie, Yan-Ming; Yang, Wei; Dai, Yi; Zhi, Ying-Jie; Zhuang, Yan; Yang, Hu

2013-09-01

To estimate treatment effects of Shuxuetong injection on abnormal changes on ALT index, that is, to explore whether the Shuxuetong injection harms liver function in clinical settings and to provide clinical guidance for its safe application. Clinical information of traditional Chinese medicine (TCM) injections is gathered from hospital information system (HIS) of eighteen general hospitals. This is a retrospective cohort study, using abnormal changes in ALT index as an outcome. A large number of confounding biases are taken into account through the generalized boosted models (GBM) and multiple logistic regression model (MLRM) to estimate the treatment effects of Shuxuetong injections on abnormal changes in ALT index and to explore possible influencing factors. The advantages and process of application of GBM has been demonstrated with examples which eliminate the biases from most confounding variables between groups. This serves to modify the estimation of treatment effects of Shuxuetong injection on ALT index making the results more reliable. Based on large scale clinical observational data from HIS database, significant effects of Shuxuetong injection on abnormal changes in ALT have not been found.

Ephedra alte (Joint Pine: An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

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Jamal R. Qasem

2012-01-01

Full Text Available A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

Ephedra alte (Joint Pine): An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan

Science.gov (United States)

Qasem, Jamal R.

2012-01-01

A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked. PMID:22645486

Ephedra alte (joint pine): an invasive, problematic weedy species in forestry and fruit tree orchards in Jordan.

Science.gov (United States)

Qasem, Jamal R

2012-01-01

A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008-2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

Preliminary design analysis of the ALT-II limiter for TEXTOR

International Nuclear Information System (INIS)

Koski, J.A.; Boyd, R.D.; Kempka, S.M.; Romig, A.D. Jr.; Smith, M.F.; Watson, R.D.; Whitley, J.B.; Conn, R.W.; Grotz, S.P.

1984-01-01

Installation of a large toroidal belt pump limiter, Advanced Limiter Test II (ALT-II), on the TEXTOR tokamak at Juelich, FRG is anticipated for early 1986. This paper discusses the preliminary mechanical design and materials considerations undertaken as part of the feasibility study phase for ALT-II. Since the actively cooled limiter blade is the component in direct contact with the plasma edge, and thus subject to the severe plasma environment, most preliminary design efforts have concentrated on analysis of the blade. The screening process which led to the recommended preliminary design consisting of a dispersion strenghthened copper or OFHC copper cover plate over an austenitic stainless steel base plate is discussed. A 1 to 3 mm thick low atomic number coating consisting of a graded plasma-sprayed Silicon Carbide-Aluminium composite is recommended subject to further experiment and evaluation. Thermal-hydraulic and stress analyses of the limiter blade are also discussed. (orig.)

Stalin Coctail: Schostakowitsch Kammersinfonie Nr. 2 (aus Streichquartett Nr. 3 op. 73). Pärt, Arvo: Collage über das Thema B-A-C-H / Susanne Benda

Index Scriptorium Estoniae

Benda, Susanne

1995-01-01

Uuest heliplaadist "Stalin Coctail: Schostakowitsch Kammersinfonie Nr. 2 (aus Streichquartett Nr. 3 op. 73). Pärt, Arvo: Collage über das Thema B-A-C-H. Cantus in memoriam B. Britten. Denisov Variationen über Haydns Kanon Tod ist ein langer Schlaf. Schtschedrin Stalin Coctail. Moskauer Virtuosen, Vladimir Spivakov. RCA/BMG-Ariola CD 09026 68061 2 (WD: 67'33")

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

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Chi-Ting Horng

2014-11-01

Full Text Available Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA. Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively. Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function.

J.S.Bach variações "Goldberg" : um guia para a formação do homem completo

OpenAIRE

Helena Jank

1988-01-01

Resumo: Dentre muitas formas possíveis de abordagem para esta obra monumental de J. S. Bach, o presente trabalho traz um enfoque eminentemente humanístico, através do qual transparece a intenção do compositor de estruturar, na forma de tema e variações um ?guia para a formação do homem completo? Esta intenção se manifesta na organização geral da obra, com uma clara divisão em três grupos de variações, nos quais são explorados aspectos técnicos, composicionais e de interpretação. Com base na ...

A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection

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Vanessa Pirrone

2010-01-01

Full Text Available An alternating copolymer of styrene and maleic acid (alt-PSMA differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1 comparable to other polyanions, such as the related compound, poly(sodium 4-styrene sulfonate (PSS. In assays using cell lines and primary immune cells, alt-PSMA was characterized by low cytotoxicity and effective inhibition of infection by HIV-1 BaL and IIIB as well as clinical isolates of subtypes A, B, and C. In mechanism of action assays, in which each compound was added to cells and subsequently removed prior to HIV-1 infection (“washout” assay, alt-PSMA caused no enhancement of infection, while PSS washout increased infection 70% above control levels. These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation.

Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE) in children admitted to a tertiary hospital.

Science.gov (United States)

Anjos, Alessandra Marques dos; Nunes, Magda Lahorgue

2009-09-01

To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE) in children admitted at the emergency and followed in a tertiary hospital. Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. During the study, 30 (4.2%) children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73%) and term infants (70%). Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.

A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway

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Wen Li

2017-10-01

Full Text Available Background/Aims: ALT1 is a novel long non-coding RNA derived from the alternatively spliced transcript of the deleted in lymphocytic leukemia 2 (DLEU2. To date, ALT1 biological roles in human vascular endothelial cells have not been reported. Methods: ALT1 was knocked down by siRNAs. Cell proliferation was analyzed by cck-8. The existence and sequence of human ALT1 were identified by 3’ rapid amplification of cDNA ends. The interaction between lncRNA and proteins was analyzed by RNA-Protein pull down assay, RNA immunoprecipitation, and mass spectrometry analysis. Results: ALT1 was expressed in human umbilical vein endothelial cells (HUVECs. The expression of ALT1 was significantly downregulated in contact-inhibited HUVECs and in hypoxia-induced, growth-arrested HUVECs. Knocking down of ALT1 inhibited the proliferation of HUVECs by G0/G1 cell cycle arrest. We observed that angiotensin converting enzyme Ⅱ(ACE2 was a direct target gene of ALT1. Knocking-down of ALT1 or its target gene ACE2 could efficiently decrease the expression of cyclin D1 via the enhanced ubiquitination and degradation, in which HIF-1α and protein von Hippel-Lindau (pVHL might be involved. Conclusion: The results suggested the human long non-coding RNA ALT1 is a novel regulator for cell cycle of HUVECs via ACE2 and cyclin D1 pathway.

The Innermost Kernel Depth Psychology and Quantum Physics. Wolfgang Pauli's Dialogue with C.G Jung

CERN Document Server

Gieser, Suzanne

2005-01-01

"The Innermost Kernel" recounts the physicist and Nobel Laureate Wolfgang Pauli and his interest in Jungian psychology, philosophy and western world-view. It is also an exploration of the intellectual setting and context of Pauli's thinking, which has its starting point in the cultural and intellectual climate of fin-de-siècle Europe. As a contribution to the general history of quantum physics this study has a special focus on the psychological and philosophical issues discussed by physicists belonging to the Copenhagen school. The work is mainly based on the correspondence of the principle characters and explores some of the central issues discussed there, as for instance the subject-object relation, complementarity, the relation of conscious and unconscious, the process underlying concept-formation, the psychology of scientific discovery, the symbolic world of alchemy, the theories of archetypes and of synchronicity. Ultimately this book is about a remarkable scientist searching for a new understanding of ...

Une lecture de Eine Übertragung de Wolfgang Hilbig à la lumière de Paul Ricœur.

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Bénédicte Terrisse

2009-12-01

Full Text Available L’objet de cette étude est de comprendre le roman de Wolfgang Hilbig (1941-2007 Eine Übertragung (1989 à partir de La Métaphore vive de Ricœur et de l’analyse des différents sens du titre du roman (métaphore, transfert, transposition. L’esthétique métaphorique, qui rappelle en de nombreux points l’esthétique mallarméenne, permet à l’auteur de réinterpréter et redécrire la réalité est-allemande en même temps que sa propre biographie. Par le recours au mythe et à l’intertextualité, ces dernières sont assimilées à la modernité esthétique, si bien que la RDA devient le territoire de la littérature moderne. Par la métaphore, Hilbig se réapproprie une réalité définie jusqu’alors par un pouvoir discrétionnaire.Ziel dieses Textes ist es, den Roman Eine Übertragung (1989 von Wolfgang Hilbig (1941-2007 mit Hilfe von Ricœurs La Métaphore vive sowie der Analyse der verschiedenen Titelbedeutungen (als Metapher, Übertragung oder Übersetzung zu verstehen. Diese Ästhetik der Metapher, die in mancher Hinsicht an die Mallarmésche erinnert, ermöglicht es dem Autor, zugleich die Realität der DDR und seine eigene Biographie neu zu interpretieren und zu beschreiben. Durch Rekurs auf Mythos und Intertextualität werden sie der ästhetischen Moderne gleichgesetzt, sodass die DDR zum Ort der Literatur der Moderne wird. Auf diese Weise gelingt es Hilbig, sich eine bis dahin von der politischen Macht dekretierte Wirklichkeit wieder anzueignen.

Alte Harfe. Vollständige Sammlung alter estnischer Volkslieder : Vorrede / Jakob Hurt

Index Scriptorium Estoniae

Hurt, Jakob, 1839-1907

2005-01-01

Eessõna rmt. : Hurt, Jakob. Vana kannel. 1. kogu : täieline kogu vanu eesti rahvalaulusid = Alte Harfe : vollständige Sammlung alter estnischen Volkslieder. Tartu, 1875-1886. - (Eesti Kirjameeste Seltsi toimetised ; 3)

The major Alternaria alternata allergen, Alt a 1: A reliable and specific marker of fungal contamination in citrus fruits.

Science.gov (United States)

Gabriel, M F; Uriel, N; Teifoori, F; Postigo, I; Suñén, E; Martínez, J

2017-09-18

The ubiquitously present spores of Alternaria alternata can spoil a wide variety of foodstuffs, including a variety of fruits belonging to the Citrus genus. The major allergenic protein of A. alternata, Alt a 1, is a species-specific molecular marker that has been strongly associated with allergenicity and phytopathogenicity of this fungal species. This study aimed to evaluate the potential of the detection of Alt a 1 as a reliable indicator of A. alternata contamination in citrus fruits. To accomplish this aim, sixty oranges were artificially infected with a spore suspension of A. alternata. Internal fruit material was collected at different incubation times (one, two and three weeks after the fungal inoculation) and used for both total RNA extraction and protein extraction. Alt a 1 detection was then performed by polymerase chain reaction (PCR) amplification using Alt a 1 specific primers and by enzyme-linked immunosorbent assay (ELISA). The experimental model presented in this work was effective to simulate the typical Alternaria black rot phenotype and its progression. Although both PCR and ELISA techniques have been successfully carried out for detecting Alt a 1 allergen in A. alternata infected oranges, the PCR method was found to be more sensitive than ELISA. Nevertheless, ELISA results were highly valuable to demonstrate that considerable amounts of Alt a 1 are produced during A. alternata fruit infection process, corroborating the recently proposed hypothesis that this protein plays a role in the pathogenicity and virulence of Alternaria species. Such evidence suggests that the detection of Alt a 1 by PCR-based assay may be used as a specific indicator of the presence of pathogenic and allergenic fungal species, A. alternata, in fruits. This knowledge can be employed to control the fungal infection and mitigate agricultural losses as well as human exposure to A. alternata allergens and toxins. Copyright © 2017 Elsevier B.V. All rights reserved.

Tom Tabor, the owner of Tabor Communications, presents Wolfgang von Rüden with the Editors Choice Award of HPCwire, which was awarded to CERN for its commitment to educating the public about high-performance computing.

CERN Multimedia

Maximilien Brice

2006-01-01

Tom Tabor, the owner of Tabor Communications, presents Wolfgang von Rüden with the Editors Choice Award of HPCwire, which was awarded to CERN for its commitment to educating the public about high-performance computing.

THE CHIMERIC ALT-VASTUS LATERALIS FREE FLAP IN RECONSTRUCTION OF ADVANCED BRONJ OF THE MAXILLA

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Francesca Toia

2015-04-01

Full Text Available ntroduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disorders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with disease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed uneventfully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.

Biomaterial properties evaluation of poly(vinyl acetate- alt-maleic anhydride)/chitosan nanocapsules

Science.gov (United States)

Raţă, Delia Mihaela; Popa, Marcel; Chailan, Jean-François; Zamfir, Carmen Lăcrămioara; Peptu, Cătălina Anişoara

2014-08-01

Nanocapsules with diameter around 100 nm based on a natural polymer (chitosan) and a synthetic polymer poly(vinyl acetate- alt-maleic anhydride) [poly(MAVA)] by interfacial condensation method were prepared. The present study proposes a new type of biocompatible nanocapsules based on poly(vinyl acetate- alt-maleic anhydride-chitosan) (MCS) able to become a reliable support for inclusion and release of drugs. The spherical shape of the nanocapsules was evidenced by scanning electron microscopy. Nanocapsules presented a good Norfloxacin loading and release capacity. Haemocompatibility tests have demonstrated that the nanocapsules present a low toxicity and a good compatibility with sanguine medium. The biocompatibility properties of the nanocapsules after their intraperitoneal administration in rats were evidenced by histopathological examination of different organs (brain, liver, kidney, and lung). The results are encouraging and the nanocapsules can be used as controlled drug delivery systems.

Counterpoint as a principle of creativity: Extracting divergent modifiers from 'The Art of Fugue' by Johann Sebastian Bach

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Giovanni Emanuele Corazza

2014-12-01

Full Text Available The main message carried by this article is that counterpoint can be taken as a model approach for the introduction of contrasting elements, not only in musical composition but also in the generation of ideas in any domain of knowledge. We start by an interdisciplinary review about the power of opposite concepts as constituting elements in nature. This is followed by the description of the DIMAI model for creative thinking, which is founded upon the dual forces of convergent and divergent thinking modalities. The main body of our work is an extraction of divergent modifiers from the Contrapunctus composed by Bach and collected in the Art of Fugue, with simple examples of application to the diversified fields of education and computer science.

Clinico-biochemical factors to early predict biliary etiology of acute pancreatitis: age, female gender, and ALT.

Science.gov (United States)

Zarnescu, N O; Costea, R; Zarnescu Vasiliu, E C; Neagu, S

2015-01-01

Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary). Multivariate analysis was performed by using binary logistic regression. There were 87 males (59.6%) and 59 females (40.4%), with a median age of 51. The etiology of acute pancreatitis was biliary in 71 patients (48.6%). Bivariate analysis found the following as significant association (p=0.001) with biliary pancreatitis: older age, female gender, and elevated AST, ALT. A binary logistic regression analysis identified as predictor factors for biliary etiology of acute pancreatitis: age OR = 1.031 (95% CI 1.004 - 1.059, p = 0.024), sex (female) OR = 2.34 (95% CI 1.022 - 5.359, p = 0.044) and ALT OR = 1.004 (95% CI 1.001 - 1.007, p =0.004). The two clinical scores included the three variables (A.S.ALT scores) in categorical format were generated and then checked with the ROC curves (areas under curve are 0.768 and 0.778). Age, female gender, and elevated ALT can help identifying cases with biliary etiology of acute pancreatitis.

ELEVATED ALANINE AMINOTRANSFERASE (ALT IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C

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Fernando Lopes GONÇALES Jr.

1998-07-01

Full Text Available The determination of aminotranferases levels is very useful in the diagnosis of hepatopathies. In recent years, an elevated serum ALT level in blood donors has been associated with an increased risk of post-transfusion hepatitis (PTH. The purpose of the study was to research the factors associated with elevated ALT levels in a cohort of voluntary blood donors and to evaluate the relationship between increased ALT levels and the development of hepatitis C (HCV infection. 166 volunteer blood donors with elevated ALT at the time of their first donation were studied. All of the donors were questioned about previous hepatopathies, exposure to hepatitis, exposure to chemicals, use of medication or drugs, sexual behaviour, contact with blood or secretions and their intake of alcohol. Every three months, the serum levels of AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride and glycemia are assessed over a two year follow-up. The serum thyroid hormone levels as well as the presence of auto-antibodies were also measured. Abdominal ultrasound was performed in all patients with persistently elevated ALT or AST levels. A needle biopsy of liver was performed in 9 donors without definite diagnostic after medical investigation. The presence of anti-HCV antibodies in 116 donors were assayed again the first clinical evaluation. At the end of follow-up period (2 years later 71 donors were tested again for the presence of anti-HCV antibodies. None of donors resulted positive for hepatitis B or hepatitis C markers during the follow-up. Of the 116 donors, 101 (87% had persistently elevated ALT serum levels during the follow-up. Obesity and alcoholism were the principal conditions related to elevated ALT serum levels in 91/101 (90.1% donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism and diabetes mellitus also were associated with increased ALT levels. Only 1/101 (0.9% had mild chronic active non A-G viral

DSLR Double Star Astrometry Using an Alt-Az Telescope

Science.gov (United States)

Frey, Thomas; Haworth, David

2014-07-01

The goal of this project was to determine if the double star's angular separation and position angle measurements could be successfully measured with a motor driven, alt-azimuth Dobsonian-mounted Newtonian telescope (without a field rotator), and a digital single-lens reflex (DSLR) camera. Additionally, the project was constrained by using as much existing equipment as much as possible, including an Apple MacBook Pro laptop and a Canon T2i camera. This project was additionally challenging because the first author had no experience with astrophotography.

The Transition between Telomerase and ALT Mechanisms in Hodgkin Lymphoma and Its Predictive Value in Clinical Outcomes

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Radhia M’kacher

2018-05-01

Full Text Available Background: We analyzed telomere maintenance mechanisms (TMMs in lymph node samples from HL patients treated with standard therapy. The TMMs correlated with clinical outcomes of patients. Materials and Methods: Lymph node biopsies obtained from 38 HL patients and 24 patients with lymphadenitis were included in this study. Seven HL cell lines were used as in vitro models. Telomerase activity (TA was assessed by TRAP assay and verified through hTERT immunofluorescence expression; alternative telomere lengthening (ALT was also assessed, along with EBV status. Results: Both TA and ALT mechanisms were present in HL lymph nodes. Our findings were reproduced in HL cell lines. The highest levels of TA were expressed in CD30−/CD15− cells. Small cells were identified with ALT and TA. Hodgkin and Reed Sternberg cells contained high levels of PML bodies, but had very low hTERT expression. There was a significant correlation between overall survival (p < 10−3, event-free survival (p < 10−4, and freedom from progression (p < 10−3 and the presence of an ALT profile in lymph nodes of EBV+ patients. Conclusion: The presence of both types of TMMs in HL lymph nodes and in HL cell lines has not previously been reported. TMMs correlate with the treatment outcome of EBV+ HL patients.

Telegramme sent on June 14 1956 from physicists Fred Reines and Clyde Cowan to Wolfgang Pauli announcing the detection, for the first time, of neutrinos. The Physics Nobel Prize in 1995 was awarded to Reines for this discovery.

CERN Document Server

Maximiliem Brice

2006-01-01

Telegramme sent on June 14 1956 from physicists Fred Reines and Clyde Cowan to Wolfgang Pauli announcing the detection, for the first time, of neutrinos. The Physics Nobel Prize in 1995 was awarded to Reines for this discovery.

Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE in children admitted to a tertiary hospital Prevalência de epilepsia e crises epilépticas como causa de eventos com aparente risco de vida (ALTE em crianças internadas em hospital terciário

Directory of Open Access Journals (Sweden)

Alessandra Marques dos Anjos

2009-09-01

Full Text Available OBJECTIVE: To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE in children admitted at the emergency and followed in a tertiary hospital. METHOD: Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. RESULTS: During the study, 30 (4.2% children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73% and term infants (70%. Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. CONCLUSION: Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.OBJETIVO: Determinar a prevalência e características clínicas de crises epilépticas e epilepsia como causa de eventos com aparente risco de vida (ALTE em crianças atendidas na emergência e acompanhadas em hospital terciário. MÉTODO: Estudo transversal com coleta prospectiva de dados através de protocolo específico para identificação da etiologia de ALTE. RESULTADOS: Foram diagnosticadas 30 crianças com ALTE perfazendo 4.2% das crianças internadas no período do estudo. Houve predominância no sexo masculino (73% e em neonatos a termo (70%. História prévia de doenças neurológicas no período neonatal e atraso no desenvolvimento neuropsicomotor ocorreram respectivamente em 13.4% e 10% dos casos. A investigação etiológica identificou 13.4% dos casos relacionados a epilepsia ou crise convulsivas e 50% idiopáticos. Apesar destes pacientes terem apresentados episódios recorrentes em nenhum caso havia a suspeita prévia de epilepsia. CONCLUSÃO: Ao investigar

Polarized high-brilliance and high-resolution soft x-ray source at ELETTRA: The performance of beamline BACH

International Nuclear Information System (INIS)

Zangrando, M.; Zacchigna, M.; Finazzi, M.; Cocco, D.; Rochow, R.; Parmigiani, F.

2004-01-01

BACH, a soft x-ray beamline for polarization-dependent experiments at the Italian synchrotron radiation facility ELETTRA, was recently completed and characterized. Its performance, in terms of energy resolution, flux and polarization, is presented. Based on two APPLE II undulators, BACH covers the energy range between 35 and 1600 eV with the control of the light polarization. The monochromator is equipped with four gratings and allows one to work either in a high resolution or in a high flux mode. After the monochromator, the beamline is split into two branches with different refocusing properties. One is optimized to exploit the performance of the soft x-ray spectrometer (ComIXS) available at the beamline. Resolving powers between 12000 at 90 eV photon energy and 6600 near 867 eV were achieved using the high-resolution gratings and the smallest available slit width (10 μm). For the high-brilliance grating, which works between 290 and 1600 eV, resolving powers between 7000 at 400 eV and 2200 at 867 eV were obtained. The flux in the experimental chamber, measured with the high-resolution gratings for linearly polarized light at the best achievable resolution, ranges between 4x10 11 photons/s at 125 eV and 2x10 10 photons/s between 900 and 1250 eV. In circularly polarized mode the flux is two times larger for energies up to 380 eV. A gain of nearly one order of magnitude is obtained for the high-brilliance grating, in accordance with theoretical predictions. Flux beyond 1.3x10 11 photons/s was measured up to 1300 eV, and thus over nearly the complete energy range covered by this high-brilliance grating, with a maximum of 1.6x10 11 photons/s between 800 and 1100 eV. First results from polarization measurements confirm a polarization above 99.7% for both linearly and circularly polarized modes at low energies. Circular dichroism experiments indicate a circular polarization beyond 90% at the Fe L 2 /L 3 edge near 720 eV

Passacaglia van J.S. Bach en Das Passagen-Werk van Walter Benjamin - literêre montage as mosaïekwerk in Memorandum. 'n Verhaal met skilderye (2006)

OpenAIRE

van Vuuren, Helize

2014-01-01

Van Niekerk se Memorandum-narratief is 'n gedenkskrif vir die elegies-realistiese skilder, Adriaan van Zyl, wat in September 2006 sterf - soos Walter Benjamin in sy laat veertigs en insgelyks met sy kunstenaarsloopbaan onderbreek. Van Niekerk stel in Memorandum vir haarself 'n uitdagende taak (soos Wiid dit formuleer aan die begin van "Memorandum 3"): om Bach se Passacaglia en fuga in C Mineur (BWV 582) (± 1715) te "vertaal" in prosa en om 'n kleiner, Afrikaanse weergawe van Benjamin se Das P...

Optical band gap energy and ur bach tail of CdS:Pb2+ thin films

Energy Technology Data Exchange (ETDEWEB)

Chavez, M.; Juarez, H.; Pacio, M. [Universidad Autonoma de Puebla, Instituto de Ciencias, Centro de Investigacion en Dispositivos Semiconductores, Av. 14 Sur, Col. Jardines de San Manuel, Ciudad Universitaria, Puebla, Pue. (Mexico); Gutierrez, R.; Chaltel, L.; Zamora, M.; Portillo, O. [Universidad Autonoma de Puebla, Facultad de Ciencias Quimicas, Laboratorio de Materiales, Apdo. Postal 1067, 72001 Puebla, Pue. (Mexico); Mathew, X., E-mail: osporti@yahoo.mx [UNAM, Instituto de Energias Renovables, Temixco, Morelos (Mexico)

2016-11-01

Pb S-doped CdS nano materials were successfully synthesized using chemical bath. Transmittance measurements were used to estimate the optical band gap energy. Tailing in the band gap was observed and found to obey Ur bach rule. The diffraction X-ray show that the size of crystallites is in the ∼33 nm to 12 nm range. The peaks belonging to primary phase are identified at 2θ = 26.5 degrees Celsius and 2θ = 26.00 degrees Celsius corresponding to CdS and Pb S respectively. Thus, a shift in maximum intensity peak from 2θ = 26.4 to 28.2 degrees Celsius is clear indication of possible transformation of cubic to hexagonal phase. Also peaks at 2θ = 13.57, 15.9 degrees Celsius correspond to lead perchlorate thiourea. The effects on films thickness and substrate doping on the band gap energy and the width on tail were investigated. Increasing doping give rise to a shift in optical absorption edge ∼0.4 eV. (Author)

Johann Sebastian Bach en zijn musici in de beide hoofdkerken te Leipzig : Een onderzoek naar hun rol, inzet en opstelling in het algemeen en naar de continuogroep en de daarin participerende instrumenten in het bijzonder

NARCIS (Netherlands)

Bijma, R.J.

2017-01-01

The study is devoted to Johann Sebastian Bach and his musicians in Leipzig’s two main churches, and to the question to which extent current opinions in musicology regarding historically-informed practice are actually correct. The core of Bach’s first Sunday choir in Leipzig consisted of the eight

Altın Fiyatlarının Yapay Sinir Ağları ile Tahmini ve Bir Uygulama

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Rıdvan YÜKSEL

2016-03-01

Full Text Available Bu çalışmada altın fiyatlarını yapay sinir ağları ile öngörmek amacıyla, altın fiyatlarını etkileyebileceği düşünülen değişkenler olan Gümüş fiyatları, Brent Petrol fiyatları, ABD doları/ EUR paritesi, EuroNext100 endeksi, Amerika Dow Jones Endeksi, 13 Hafta vadeli ABD bonosu faiz oranı ve ABD TÜFE endeksi kullanılarak modeller kurulmuştur. Yapay sinir ağları ile kurulan modellerden elde edilen tahmin sonuçları, gerçek değerler ile R2, RMSE, MAE ve MAPE (% gibi performans kriterleri hesaplanarak karşılaştırılmıştır. Elde edilen bulgular yapay sinir ağlarının altın fiyatlarının tahmininde başarı ile kullanılabileceğini göstermektedir. Yapılan duyarlılık analizinin sonuçları değerlendirildiğinde altın fiyatlarını etkileyen faktörlerin başında gümüş ve petrol fiyatlarının geldiği tespit edilmiştir.

Ein Fließgewässer im urbanen Umfeld. Analyse des ökologischen Zustandes des unteren Belmer Baches (Osnabrück, Niedersachsen) anhand des Makrozoobenthos

DEFF Research Database (Denmark)

Rasch, Peter; Trapp, Stefan

2000-01-01

The organic pollution of the lower Belmer Bach can be attributed to its agriculturally intensively used drainage area. Already before entering the urbanized region, the macrozoobenthos is poor in species due to saprobic pollution and the structural poverty of the waterbed and the banks.......When comparing the species numbers of a reference sampling plot located before the urban region and a sampling plot situated within this region, hardly any differences could be ascertained. The longitudinal isolation and the rise in temperature of i 1 °C in the urban brook section negatively influence its fauna...

Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT in Fingerstick and Venipuncture Samples.

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Sidhartha Jain

Full Text Available A paper-based, multiplexed, microfluidic assay has been developed to visually measure alanine aminotransferase (ALT in a fingerstick sample, generating rapid, semi-quantitative results. Prior studies indicated a need for improved accuracy; the device was subsequently optimized using an FDA-approved automated platform (Abaxis Piccolo Xpress as a comparator. Here, we evaluated the performance of the optimized paper test for measurement of ALT in fingerstick blood and serum, as compared to Abaxis and Roche/Hitachi platforms. To evaluate feasibility of remote results interpretation, we also compared reading cell phone camera images of completed tests to reading the device in real time.96 ambulatory patients with varied baseline ALT concentration underwent fingerstick testing using the paper device; cell phone images of completed devices were taken and texted to a blinded off-site reader. Venipuncture serum was obtained from 93/96 participants for routine clinical testing (Roche/Hitachi; subsequently, 88/93 serum samples were captured and applied to paper and Abaxis platforms. Paper test and reference standard results were compared by Bland-Altman analysis.For serum, there was excellent agreement between paper test and Abaxis results, with negligible bias (+4.5 U/L. Abaxis results were systematically 8.6% lower than Roche/Hitachi results. ALT values in fingerstick samples tested on paper were systematically lower than values in paired serum tested on paper (bias -23.6 U/L or Abaxis (bias -18.4 U/L; a correction factor was developed for the paper device to match fingerstick blood to serum. Visual reads of cell phone images closely matched reads made in real time (bias +5.5 U/L.The paper ALT test is highly accurate for serum testing, matching the reference method against which it was optimized better than the reference methods matched each other. A systematic difference exists between ALT values in fingerstick and paired serum samples, and can be

Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1

DEFF Research Database (Denmark)

Dossing, Kristina B. V.; Binderup, Tina; Kaczkowski, Bogumil

2014-01-01

by miR-129-5p. let-7 overexpression inhibited growth of carcinoid cell lines, and let-7 inhibition increased protein content of the transcription factor BACH1 and its targets MMP1 and HMGA2, all known to promote bone metastases. Immunohistochemistry analysis revealed that let-7 targets are highly...

On the hydrology and fluvial sediment transport of the proglacial river Riffler Bach (Weißseeferner, Ötztal Alps, Tyrol)

Science.gov (United States)

Morche, David; Baewert, Henning; Weber, Martin; Schmidt, Karl-Heinz

2013-04-01

The hydrology of proglacial rivers is strongly affected by glacier melting. With ongoing glacier retreat the proportion of glacier meltwater in proglacial rivers is declining over longer time periods. Snow melt or rain fall events will play a more important role as water source. Due to glacial erosion the glacier system is also an important player in the orchestra of sediment sources/processes contributing to proglacial sediment budgets. The consequence of increasing deglaciation is a growing importance of other sediment sources/processes, mainly known as paraglacial, for sediment budgets in glacier forefields. The sediment export out of proglacial areas is mainly done by solid river load. Knowledge on the quantity of the exported sediments is important for reservoir management and torrent control. In order to measure fluvial sediment transport in the catchment area of the Gepatsch reservoir in the Ötztal Alps (Tyrol/Austria) we have installed a gauging station at the proglacial river Riffler Bach in June 2012. The catchment area of this station is about 20 km² with an altitudinal range from 1929 m to 3518 m. The higher altitudes in the southern part of the area are covered by the glacier Weißseeferner. Our station is equipped with an automatic water sampler (AWS 2002) and probes for water level, turbidity and electrical conductivity. All parameters are recorded in 5-15 minute intervals during the ablation period. Discharge is measured with current meters during wadable stages and salt dilution during higher floods. Bed load is measured concurrent to discharge measurements using a Helley-Smith sampler. In 2012, 189 water samples were taken and will be analyzed for suspended sediment concentration and ion content. Additionally, the grain size distribution will be determined using a Malvern laser diffractometer. Rating-curves will be used to calculate discharge from stage recordings. Solid load of the Riffler Bach will be quantified using the discharge data and

Bach Is the Father of Harmony: Revealed by a 1/f Fluctuation Analysis across Musical Genres.

Science.gov (United States)

Wu, Dan; Kendrick, Keith M; Levitin, Daniel J; Li, Chaoyi; Yao, Dezhong

2015-01-01

Harmony is a fundamental attribute of music. Close connections exist between music and mathematics since both pursue harmony and unity. In music, the consonance of notes played simultaneously partly determines our perception of harmony; associates with aesthetic responses; and influences the emotion expression. The consonance could be considered as a window to understand and analyze harmony. Here for the first time we used a 1/f fluctuation analysis to investigate whether the consonance fluctuation structure in music with a wide range of composers and genres followed the scale free pattern that has been found for pitch, melody, rhythm, human body movements, brain activity, natural images and geographical features. We then used a network graph approach to investigate which composers were the most influential both within and across genres. Our results showed that patterns of consonance in music did follow scale-free characteristics, suggesting that this feature is a universally evolved one in both music and the living world. Furthermore, our network analysis revealed that Bach's harmony patterns were having the most influence on those used by other composers, followed closely by Mozart.

Preparation of a Sepia Melanin and Poly(ethylene-alt-maleic Anhydride Hybrid Material as an Adsorbent for Water Purification

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Guido Panzarasa

2018-01-01

Full Text Available Meeting the increasing demand of clean water requires the development of novel efficient adsorbent materials for the removal of organic pollutants. In this context the use of natural, renewable sources is of special relevance and sepia melanin, thanks to its ability to bind a variety of organic and inorganic species, has already attracted interest for water purification. Here we describe the synthesis of a material obtained by the combination of sepia melanin and poly(ethylene-alt-maleic anhydride (P(E-alt-MA. Compared to sepia melanin, the resulting hybrid displays a high and fast adsorption efficiency towards methylene blue (a common industrial dye for a wide pH range (from pH 2 to 12 and under high ionic strength conditions. It is easily recovered after use and can be reused up to three times. Given the wide availability of sepia melanin and P(E-alt-MA, the synthesis of our hybrid is simple and affordable, making it suitable for industrial water purification purposes.

Alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom promotes positive inotropism and chronotropism in fish heart.

Science.gov (United States)

Monteiro, D A; Kalinin, A L; Selistre-de-Araujo, H S; Vasconcelos, E S; Rantin, F T

2016-02-01

Alternagin-C (ALT-C) is a disintegrin-like protein purified from the venom of the snake, Rhinocerophis alternatus. Recent studies showed that ALT-C is able to induce vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, angiogenesis and to increase myoblast viability. This peptide, therefore, can play a crucial role in tissue regeneration mechanisms. The aim of this study was to evaluate the effects of a single dose of alternagin-C (0.5 mg kg(-1), via intra-arterial) on in vitro cardiac function of the freshwater fish traíra, Hoplias malabaricus, after 7 days. ALT-C treatment increased the cardiac performance promoting: 1) significant increases in the contraction force and in the rates of contraction and relaxation with concomitant decreases in the values of time to the peak tension and time to half- and 90% relaxation; 2) improvement in the cardiac pumping capacity and maximal electrical stimulation frequency, shifting the optimum frequency curve upward and to the right; 3) increases in myocardial VEGF levels and expression of key Ca(2+)-cycling proteins such as SERCA (sarcoplasmic reticulum Ca(2+)-ATPase), PLB (phospholamban), and NCX (Na(+)/Ca(2+) exchanger); 4) abolishment of the typical negative force-frequency relationship of fish myocardium. In conclusion, this study indicates that ALT-C improves cardiac function, by increasing Ca(2+) handling efficiency leading to a positive inotropism and chronotropism. The results suggest that ALT-C may lead to better cardiac output regulation indicating its potential application in therapies for cardiac contractile dysfunction. Copyright © 2015 Elsevier Ltd. All rights reserved.

"Almha La Vengadora": Protagonista del indigenismo de neovanguardia alteño

Directory of Open Access Journals (Sweden)

Maria Irina Soto-Mejia

2016-03-01

Este artículo discute la obra de Crispín Portugal (1976-2007, un escritor alteño, en el contexto de la lucha contra la pobreza y el racismo que enfrentan a las ciudades de El Alto y La Paz, y del movimiento en contra del mercado  que comenzó en Argentina produciendo libros con tapas de cartón compradas a los cartoneros. Portugal y otros escritores indígenas iniciaron un proyecto editorial llamado Yerba Mala Cartonera, que cuenta con su propio blog, para diseminar la literatura boliviana que no cuenta con otros medios de difusión. A través de la revisión de un cuento de Portugal (Almha La Vengadora que describe a una chola luchadora de El Alto cuyo nombre en el cuadrilátero es “la vengadora”, este trabajo plantea la configuración de un indigenismo alteño de neovanguardia equiparable al vanguardismo de Gamaliel Churata.  Con este propósito, presta especial atención a El Alto –la ciudad indígena más grande de Latinoamérica- situándolo como escenario clave para el desarrollo de una neovanguardia que se alimenta del neoliberalismo fallido para configurar una propuesta de modernidad que recupera el pasado indígena aymara para inventar otras formas de futuro.

Bach Is the Father of Harmony: Revealed by a 1/f Fluctuation Analysis across Musical Genres.

Directory of Open Access Journals (Sweden)

Dan Wu

Full Text Available Harmony is a fundamental attribute of music. Close connections exist between music and mathematics since both pursue harmony and unity. In music, the consonance of notes played simultaneously partly determines our perception of harmony; associates with aesthetic responses; and influences the emotion expression. The consonance could be considered as a window to understand and analyze harmony. Here for the first time we used a 1/f fluctuation analysis to investigate whether the consonance fluctuation structure in music with a wide range of composers and genres followed the scale free pattern that has been found for pitch, melody, rhythm, human body movements, brain activity, natural images and geographical features. We then used a network graph approach to investigate which composers were the most influential both within and across genres. Our results showed that patterns of consonance in music did follow scale-free characteristics, suggesting that this feature is a universally evolved one in both music and the living world. Furthermore, our network analysis revealed that Bach's harmony patterns were having the most influence on those used by other composers, followed closely by Mozart.

2017-04-28_W88 ALT 370 Program Overview(OUO).

Energy Technology Data Exchange (ETDEWEB)

Daniels, Vonceil

2017-04-01

All major program milestones have been met and the program is executing within budget. The ALT 370 program achieved Phase 6.4 authorization in February of this year. Five component Final Design Reviews (FDRs) have been completed, indicating progress in finalizing the design and development phase of the program. A series of ground-based qualification activities have demonstrated that designs are meeting functional requirements. The first fully functional flight test, FCET-53, demonstrated end-to-end performance in normal flight environments in February. Similarly, groundbased nuclear safety and hostile environments testing indicates that the design meets requirements in these stringent environments. The first in a series of hostile blast tests was successfully conducted in April.

巴赫型音乐对波普尔“客观知识”学说的影响%The Influence of Bach-Type Music on Popper＇s Thought of Objective Knowledge

Institute of Scientific and Technical Information of China (English)

何超

2012-01-01

摘耍：波普尔的“客客观知识”在其客观性属性上，类似于超脱贝多芬的自我性、体现客观美感的巴赫型音乐。巴赫音乐音符与音符之间具有严谨又不失美感的客观秩序、不能被理性所摒弃的严密的数的逻辑构架，其客观性诉求与波普尔寻求超脱于主观、从而能够在客观形式中达到统一的知识类型——“客观知识”学说建构之间，存在发生学关联，直接导致波普尔对世界2与世界3的医分。巴赫型音乐对于波普尔科学哲学的深刻影响，为音乐与科学、哲学之间的彼此通约，提供了典型的个案。关键词：波普尔；巴赫型音乐；贝多芬；客观知识；世界3%The objective style of Bach type music enlightens in depth the thought of ＂objective knowledge＂ proposed by Karl Popper. Beethoven＇s music gives expression to ＂subjective＂ appeal, while Bach-type music, ＂subjective＂ soberness and reason in style. Karl Popper＇s ＂objective knowledge＂ is based on the partition of three worlds. As ＂world 3＂, it is characterized by objectivity, autonomy, shareability, etc. The isostructuralism and coherence in style between ＂objective knowledge＂ and Bach- type music provide an illustrative case for the commensuration of art and philosophy in certain sense through the reflective han- dling by Karl Popper.

The psychologist who is not a psychologist: a deconstructive reading of Wolfgang Giegerich's idea of psychology proper.

Science.gov (United States)

Marlan, Stanton

2016-04-01

This paper represents an archetypal and deconstructive reading of the work of Wolfgang Giegerich. In an attempt to extend and philosophically develop Jung's late-life view of the objective psyche, Giegerich, via Hegel, defines psychology proper as fundamentally separate from the everyday person and the 'human, all-too-human' aspects of the soul. It is argued that, in so doing, Giegerich removes the human person from being the primary focus of his psychology and creates instead a hierarchy of ideas and values privileging syntax over semantics, the logical over the empirical, and thinking over imagination. This bypasses the emotionality of the everyday person/patient and also renders psychology proper unable to address the day-to-day practice of the analyst. Giegerich attempts to rectify this problem by re-incorporating what he had previously rejected, making his theory more complex than is apparent in his binary oppositions. In the end, however, it remains a question to what extent Giegerich is successful in avoiding a binary scission (Saban 2015) or a tendency to regularly de-emphasize the human aspect of the soul (Hoedl 2015) in his need to continue to heroically push off from the ego seeking total freedom from neurosis and from our humanity. © 2016, The Society of Analytical Psychology.

Predictive value of serum ALT and T-cell receptor beta variable chain for HBeAg seroconversion in chronic hepatitis B patients during tenofovir treatment.

Science.gov (United States)

Yang, Jiezuan; Yan, Dong; Guo, Renyong; Chen, Jiajia; Li, Yongtao; Fan, Jun; Fu, Xuyan; Yao, Xinsheng; Diao, Hongyan; Li, Lanjuan

2017-03-01

Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment. The relationship between the hepatitis B virus (HBV) deoxyribonucleic acid (DNA) and Treg and alanine aminotransferase (ALT) levels was analyzed, respectively. The molecular profiles of T-cell receptor beta variable chain (TRBV) were determined using gene melting spectral pattern. For the seroconverted 12 patients, ALT declined to normal levels by week 24 and remained at this level in subsequent treatment; moreover, the predictive cutoff value of ALT for HBeAg seroconversion (SC) was 41.5 U/L at week 24. The positive correlation between HBV DNA and Treg and ALT was significant in SC patients, but not in non-SC patients. Six TRBV families (BV3, BV11, BV12, BV14, BV20, and BV24) were predominantly expressed in SC patients at baseline. The decline of ALT could be used to predict HBeAg seroconversion for CHB patients during TDF treatment. In addition, the profile of Tregs and TRBVs may be associated with HBeAg seroconversion and could also be a potential indicator for predicting HBeAg SC and treatment outcome for CHB patients.

Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

Index Scriptorium Estoniae

2009-01-01

Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

Geometry of deformed black holes. II. Schwarzschild hole surrounded by a Bach-Weyl ring

Science.gov (United States)

Basovník, M.; Semerák, O.

2016-08-01

We continue to study the response of black-hole space-times on the presence of additional strong sources of gravity. Restricting ourselves to static and axially symmetric (electro)vacuum exact solutions of Einstein's equations, we first considered the Majumdar-Papapetrou solution for a binary of extreme black holes in a previous paper, while here we deal with a Schwarzschild black hole surrounded by a concentric thin ring described by the Bach-Weyl solution. The geometry is again revealed on the simplest invariants determined by the metric (lapse function) and its gradient (gravitational acceleration), and by curvature (Kretschmann scalar). Extending the metric inside the black hole along null geodesics tangent to the horizon, we mainly focus on the black-hole interior (specifically, on its sections at constant Killing time) where the quantities behave in a way indicating a surprisingly strong influence of the external source. Being already distinct on the level of potential and acceleration, this is still more pronounced on the level of curvature: for a sufficiently massive and/or nearby (small) ring, the Kretschmann scalar even becomes negative in certain toroidal regions mostly touching the horizon from inside. Such regions have been interpreted as those where magnetic-type curvature dominates, but here we deal with space-times which do not involve rotation and the negative value is achieved due to the electric-type components of the Riemann/Weyl tensor. The Kretschmann scalar also shapes rather nontrivial landscapes outside the horizon.

PDMS-modified poly(styrene-alt-maleic anhydride)s as water-borne coatings based on surfactant-free latexes

NARCIS (Netherlands)

Gunbas, I.D.; Wouters, M.E.L.; Benthem, R.A.T.M. van; Koning, C.E.; Noordover, B.A.J.

2013-01-01

In this work, two series of PDMS-modified poly(styrene-alt-maleic anhydride)s (PSMA) were prepared by the partial imidization of their anhydride groups with mono-functional, amine-terminated polydimethyl siloxanes (PDMS-NH2) with two different molecular weights. Subsequently, surfactant-free

Goethe: A bipolar personality? Periodicity of affective states in Johann Wolfgang von Goethe as reflected by Paul Julius Möbius.

Science.gov (United States)

Steinberg, Holger; Schönknecht, Peter

2018-01-01

This paper aims to investigate the character and etiological basis of German poet Johann Wolfgang von Goethe's mental disorder. From 1898, German neuropsychiatrist Paul Julius Möbius developed the hypothesis that Goethe's work provided several hints for the notion that the German poet suffered from a distinct bipolar disorder. The paper investigates Möbius's psychopathographic study on Goethe and his hypothesis of a mood periodicity in Goethe against the mirror of modern concepts. Möbius came to the conclusion that Goethe's illness was bipolar in character and became visible at intervals of seven years and lasted for about two years. The majority of Möbius's contemporary psychiatric colleagues (Emil Kraepelin, Max Isserlin, Ernst Kretschmer, Josef Breuer) supported this view which has still not been convincingly challenged. In present-day terms, Möbius's hypothesis can be best mirrored as a subclinical foundation of mood disorder. Furthermore, with his extensive study, Möbius disproved the common notion that Goethe had suffered from an illness as the result of a syphilitic infection.

Phase 1 trial of ALT-801, an interleukin-2/T cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies

Science.gov (United States)

Fishman, Mayer N.; Thompson, John A.; Pennock, Gregory K.; Gonzalez, Rene; Diez, Luz M.; Daud, Adil I.; Weber, Jeffery S.; Huang, Bee Y.; Tang, Shamay; Rhode, Peter R.; Wong, Hing C.

2014-01-01

Purpose ALT-801 is a bifunctional fusion protein comprising interleukin-2 (IL-2) linked to a soluble, single-chain T cell receptor domain that recognizes a peptide epitope (aa264-272) of the human p53 antigen displayed on cancer cells in the context of HLA-A*0201 (p53+/HLA-A*0201). We evaluated the safety, pharmacokinetics and pharmacodynamics of ALT-801 in p53+/HLA-A*0201 patients with metastatic malignancies. Experimental Design p53+/HLA-A*0201 patients were treated with ALT-801 on a schedule of 4 daily 15-minute intravenous infusions, then 10 days rest and 4 more daily infusions. Cohorts of patients were treated at 0.015, 0.040, and 0.080 mg/kg/dose. Results Four, sixteen, and six patients were treated at the 0.015, 0.04 and 0.08 mg/kg cohorts, respectively. Two dose limiting toxicities (a grade 4 transient thrombocytopenia and a myocardial infarction) in the 0.08 mg/kg cohort established the maximum tolerated dose (MTD) at 0.04 mg/kg. Patients treated at the MTD experienced toxicities similar to those associated with high-dose IL-2 but of lesser severity. The serum half-life of ALT-801 was 4 hours and ALT-801 serum recovery was as expected based on the dose administered. ALT-801 treatment induced an increase of serum interferon-γ but not tumor necrosis factor-α. Response assessment showed 10 subjects with stable disease at at least 11 weeks, and in one who had melanoma metastasis, there is an ongoing complete absence of identifiable disease after resection of radiographically identified lesions. Conclusion This first-in-man study defines an ALT-801 regimen that can be administered safely and is associated with immunological changes of potential antitumor relevance. PMID:21994418

Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation.

Science.gov (United States)

Wang, Shuai; Hannafon, Bethany N; Wolf, Roman F; Zhou, Jundong; Avery, Jori E; Wu, Jinchang; Lind, Stuart E; Ding, Wei-Qun

2014-05-01

The effect of docosahexaenoic acid (DHA) on heme oxygenase-1 (HO-1) expression in cancer cells has never been characterized. This study examines DHA-induced HO-1 expression in human cancer cell model systems. DHA enhanced HO-1 gene expression in a time- and concentration-dependent manner, with maximal induction at 21 h of treatment. This induction of HO-1 expression was confirmed in vivo using a xenograft nude mouse model fed a fish-oil-enriched diet. The increase in HO-1 gene transcription induced by DHA was significantly attenuated by the antioxidant N-acetyl cysteine, suggesting the involvement of oxidative stress. This was supported by direct measurement of lipid peroxide levels after DHA treatment. Using a human HO-1 gene promoter reporter construct, we identified two antioxidant response elements (AREs) that mediate the DHA-induced increase in HO-1 gene transcription. Knockdown of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression compromised the DHA-induced increase in HO-1 gene transcription, indicating the importance of the Nrf2 pathway in this event. However, the nuclear protein levels of Nrf2 remained unchanged upon DHA treatment. Further studies demonstrated that DHA reduces nuclear Bach1 protein expression by promoting its degradation and attenuates Bach1 binding to the AREs in the HO-1 gene promoter. In contrast, DHA enhanced Nrf2 binding to the AREs without affecting nuclear Nrf2 expression levels, indicating a new cellular mechanism that mediates DHA's induction of HO-1 gene transcription. To our knowledge, this is the first characterization of DHA-induced HO-1 expression in human malignant cells. Copyright © 2014 Elsevier Inc. All rights reserved.

#whitegenocide, the Alt-right and Conspiracy Theory: How Secrecy and Suspicion Contributed to the Mainstreaming of Hate

Directory of Open Access Journals (Sweden)

Andrew F. Wilson,

2018-02-01

Full Text Available This article considers the relationship between “hashtag activism” as it is currently being used by the alt-right and the tendency to draw on conspiracy theory that Richard Hofstadter identified as being prevalent among what he termed “pseudo-conservatives” half a century earlier. Both the alt-right and Hofstadter’s “pseudo-conservatives” can be characterised by a pronounced populist nationalism that understands its aims as protecting a particular way of life whilst drawing on an aggrieved sense of injustice at being conspired against by an unseen enemy. That this “enemy” is typically foreign in actuality or in spirit confirms the cultural dimension on which their politics is played out. It is argued here that this paranoid populist nationalism has been figuratively drawn upon in the rhetoric of Donald Trump and that this apparent openness to the “pseudo-conservative” discourse on nationalism has provided a bridging effect via which far right elements are seeking to normalize extremist viewpoints

Naised käsu korras firmade juhatusse! Jah või ei? / Kairi Alt, Aveli Kippari, Karl Koort... [jt.

Index Scriptorium Estoniae

2011-01-01

Küsimusele vastavad Columbus IT Partner Eesti AS personalijuht Kairi Alt, Stele ja Riveli omanik Aveli Kippari, AS Panaviatic'i turundusjuht Karl Koort, OÜ Tarkvara Tehnoloogia Arenduskeskuse tegevjuht Indrek Vainu, AS PricewaterhouseCoopers auditiosakonna direktor Eva Jansen, Kalev Chocolate Factory tootmisjuht Hardo Reinike

Simple synthesis of P(Cbz-alt-TBT) and PCDTBT by combining direct arylation with suzuki polycondensation of heteroaryl chlorides.

Science.gov (United States)

Lombeck, Florian; Matsidik, Rukiya; Komber, Hartmut; Sommer, Michael

2015-01-01

Direct arylation (DA) of 2-chlorothiophene and 2-chloro-3-hexylthiophene with 4,7-dibromo-2,1,3-benzothiadiazole is used to synthesize 4,7-bis(5-chloro-2-thienyl)-2,1,3-benzothiadiazole (TBTCl2) and 4,7-bis(5-chloro-4-hexyl-2-thienyl)-2,1,3-benzothiadiazole (DH-TBTCl2) in one step. Suitable conditions of the Suzuki polycondensations (SPC) of TBTCl2 and DH-TBTCl2 with the carbazole comonomer CbzPBE2 are established, furnishing PCDTBT and P(Cbz-alt-TBT) with high molecular weight and yield. Compared with control samples made from the corresponding dibromides, high-temperature NMR and UV-vis spectroscopy indicate similar properties for PCDTBT but an increased content of Cbz-Cbz homocouplings for P(Cbz-alt-TBT). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Diorganosilacetylene-alt-diorganosilvinylene polymers and a process densifying porous silicon-carbide bodies

Science.gov (United States)

Barton, Thomas J.; Ijadi-Maghsoodi, Sina; Pang, Yi

1994-05-17

The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylene-alt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.tbd.C--(R.sup.3)(R.sup.4)Si--CH=CH--].sub.n-- , wherein n.gtoreq.2; and each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.

Common reference intervals for aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) in serum: results from an IFCC multicenter study.

Science.gov (United States)

Ceriotti, Ferruccio; Henny, Joseph; Queraltó, Josep; Ziyu, Shen; Özarda, Yeşim; Chen, Baorong; Boyd, James C; Panteghini, Mauro

2010-11-01

Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim of this study was to define the reference intervals (RIs) for these enzymes in adults, paying attention to standardization of the methods used and careful selection of the reference population. AST, ALT and GGT were measured with commercial analytical systems standardized to the IFCC-recommended reference measurement systems. Three centers (two in Italy and one in China) measured their own freshly collected samples; one of these centers also measured frozen samples from the Nordic Countries RI Project and from a Turkish center. RIs were generated using non-parametric techniques from the results of 765 individuals (411 females and 354 males, 18-85 years old) selected on the basis of the results of other laboratory tests and a specific questionnaire. AST results from the four regions (Milan, Beijing, Bursa and Nordic Countries) were statistically different, but these differences were too small to be clinically relevant. Likewise, differences between the upper reference limits for genders was only 1.7 U/L (0.03 μkat/L), allowing a single RI of 11-34 U/L (0.18-0.57 μkat/L) to be defined. Interregional differences were not statistically significant for ALT, but partitioning was required due to significant gender differences. RIs for ALT were 8-41 U/L (0.13-0.68 μkat/L) for females and 9-59 U/L (0.15-0.99 μkat/L) for males, respectively. The upper reference limits for GGT from the Nordic Country population were higher than those from the other three regions and results from this group were excluded from final calculations. The GGT RIs were 6-40 U/L (0.11-0.66 μkat/L) for females and 12-68 U/L (0.20- 1.13 μkat/L) for males, respectively. For AST and ALT, the implementation of common RIs appears to be possible, because no differences between regions were observed. However, a common RI for GGT that is

Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus.

Science.gov (United States)

Monteiro, Diana Amaral; Selistre-de-Araújo, Heloisa Sobreiro; Tavares, Driele; Fernandes, Marisa Narciso; Kalinin, Ana Lúcia; Rantin, Francisco Tadeu

2017-09-28

Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis. The aim of this study was to evaluate the systemic effects of a single dose of alternagin-C (0.5 mg·kg -1 , via intra-arterial) on oxidative stress biomarkers, histological alterations, vascular endothelial growth factor (VEGF) production, and the degree of vascularization in the liver of the freshwater fish traíra, Hoplias malabaricus , seven days after the initiation of therapy. ALT-C treatment increased VEGF levels and hepatic angiogenesis. ALT-C also enhanced hepatic antioxidant enzymes activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, decreasing the basal oxidative damage to lipids and proteins in the fish liver. These results indicate that ALT-C improved hepatic tissue and may play a crucial role in tissue regeneration mechanisms.

Living between reality and virtuality – on the work of Monika Fleischmann and Wolfgang Strauss

Directory of Open Access Journals (Sweden)

Ryszard W. Kluszczyński

2012-12-01

Full Text Available It becomes clear that new media begin to function as multiplicators of new worlds, creating numerous virtual environments. This diversified, compound reality in many ways takes a shape of a network. New media art in this field of events has various functions. From one hand, it is one of the most refined instruments in the process of networkisation. From the other hand, it is also the tool of verification for these processes, critically but without prejudice evaluating its development, attentively observing what shapes do they took, as well as their real or possible results. In each case, new media art is an active participant of these processes, making full use of possibilities provided by the network system. Frequently while performing its activities it is intersected or linked with the processes which are a part of the world of science, creating together with them new cultural paradigm. Monika Fleischmann and Wolfgang Strauss undertook their joint, creative actions in combined fields of art and science in late 1980s. It was a special moment of a breakthrough for the formation of the character of modern civilization. Events taking place back then, as being a part of a sphere of phenomena generated by communication and information sciences, had enormous influence on the process of shaping a new cultural formation – cyber culture, and because of this, at the same time, had enormous influence on our ways of reality perception. From the beginning of their cooperation, Fleischmann and Strauss have found the tools appropriate for the realization of their works in the environemt of the internet. Their’s art has developed in parallel to the development of computer and internet environment, depicting dynamics of this network and inscribing, with the undertaken issues, in the circle of problems generated through out a development and transformations of accompanied cyber-cultural concepts.

Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias

Directory of Open Access Journals (Sweden)

Justino Alavez Domínguez

2006-12-01

Full Text Available Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral para el estudio de la dinámica del virus de la hepatitis C (VHC, con el modelo de la dinámica viral con alanina aminotransferasa (ALT. En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aThe standard model of three populations (healthy and unhealthy hepatocytes, and viral load for the study of the dynamics of hepatitis C virus (HCV, is compared with viral dynamic model with alanine aminotransferase (ALT. In terms of the threshold parameter that it’s the same for both models, the existence and local asymptotic stability of the endemically infected equilibrium steady state, and the global stability of the healthy individual equilibrium steady state are established. Furthermore, an experimental study is presented showing that it’s possible to carry out the monitoring of hepatic damage biopsies free by numerical parameter estimation, considering only viral load and ALT levels measurements and a reasonable assessment of pretreatment hepatic damage.

Comparing the characteristics of highly cited titles and highly alted titles

Energy Technology Data Exchange (ETDEWEB)

Didegah, F.; Bowman, T.D.; Bowman, S.; Hartley, J.

2016-07-01

This study examines differences in the types of titles for articles that show high altmetric activity (highly alted articles) versus highly cited articles. This work expands on previous research on document titles in combination with a grounded theory approach to develop a codebook in which articles were manually coded based on 11 characteristics. The results show that there are differences and similarities in titles across many of the examined characteristics; highly cited titles and highly mentioned titles on Wikipedia have some similar characteristics such as they have the the highest percentage of substantive words; in addition, there are no or very few titles referencing outside or with humor/lightness on both platforms. Twitter and Facebook also showed some similarities having the highest percentage of humorous/light titles and lowest percentage of substantive words in their titles. (Author)

Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L. as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT

Directory of Open Access Journals (Sweden)

Dimas Adhi Pradana

2016-12-01

Full Text Available This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L. with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT. A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1.

Visions of sustainable urban energy systems. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Pietzsch, Ursula [HFT Stuttgart (Germany). zafh.net - Centre of Applied Research - Sustainable Energy Technology; Mikosch, Milena [Steinbeis-Zentrum, Stuttgart (Germany). Europaeischer Technologietransfer; Liesner, Lisa (eds.)

2010-09-15

Within the polycity final conference from 15th to 17th September, 2010, in Stuttgart (Federal Republic of Germany) the following lectures were held: (1) Visions of sustainable urban energy system (Ursula Eicker); (2) Words of welcome (Tanja Goenner); (3) Zero-energy Europe - We are on our way (Jean-Marie Bemtgen); (4) Polycity - Energy networks in sustainable cities An introduction (Ursula Pietzsch); (5) Energy efficient city - Successful examples in the European concerto initiative (Brigitte Bach); (6) Sustainable building and urban concepts in the Catalonian polycity project contributions to the polycity final conference 2010 (Nuria Pedrals); (7) Energy efficient buildings and renewable supply within the German polycity project (Ursula Eicker); (8) Energy efficient buildings and cities in the US (Thomas Spiegehalter); (9) Energy efficient communities - First results from an IEA collaboration project (Reinhard Jank); (10) The European energy performance of buildings directive (EPBD) - Lessons learned (Eduardo Maldonado); (11) Passive house standard in Europe - State-of-the-art and challenges (Wolfgang Feist); (12) High efficiency non-residential buildings: Concepts, implementations and experiences from the UK (Levin Lomas); (13) This is how we can save our world (Franz Alt); (14) Green buildings and renewable heating and cooling concepts in China (Yanjun Dai); (15) Sustainable urban energy solutions for Asia (Brahmanand Mohanty); (16) Description of ''Parc de l'Alba'' polygeneration system: A large-scale trigeneration system with district heating within the Spanish polycity project (Francesc Figueras Bellot); (17) Improved building automation and control systems with hardware-in-the loop solutions (Martin Becker); (18) The Italian polycity project area: Arquata (Luigi Fazari); (19) Photovoltaic system integration: In rehabilitated urban structures: Experiences and performance results from the Italian polycity project in Turin (Franco

Synthesis and Properties of the Metallo-Supramolecular Polymer Hydrogel Poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3

KAUST Repository

Al-Dossary, Mona S.

2014-05-01

Gels are a special class of materials which are composed of 3D networks of crosslinked polymer chains that encapsulate liquid/air in the matrix. They can be classified into organogels or hydrogels (organic solvent for organogel and water for hydrogel). For hydrogels that contain metallic elements in the form of ions, the term of metallo-supramolecular polymer hydrogel (MSPHG) is often used. The aim of this project is to develop a kind of new MSPHG and investigate its properties and possible applications. The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-monosodium maleate) (PVM/Na-MA). By addition of AgNO3-solution, the formation of the silver(I) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]∙AgNO3 is obtained. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(I) cations. The supercritical CO2 dried silver(I) hydrogel was characterized by FT-IR, SEM-EDAX, TEM, TGA and Physical adsorption (BET) measurements. The intact silver(I) hydrogel was characterized by cryo-SEM. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(II) cations without disintegration of the hydrogel. The silver(I) hydrogel shows effective antibacterial activity and potential application as burn wound dressing.

Academic learning time in physical education (ALT-PE: is it related to fundamental movement skill acquisition and learning?. Tiempo de aprendizaje académico en educación física (ALT-PE: ¿tiene que ver con la adquisición y aprendizaje de habilidades motrices fundamentales?

Directory of Open Access Journals (Sweden)

Loza Olave, Edmundo

2007-01-01

Full Text Available AbstractIn this study, the relationship between time-variables of the physical education lesson and fundamental movement skill acquisition and learning was examined. One hundred and ten first grade students and their six physical educators participated. Students were pre-, post-, and re-tested both qualitatively and quantitatively on overhand throwing and catching. The Test of Gross Motor Development (Ulrich, 1985 was used for the assessment of qualitative skill performance and the Michigan Educational Assessment Program (MEAP, 1984 for the assessment of quantitative skill performance. Between pre- and post-tests students received an eight lessons unit instruction with emphasis on overhand throwing and catching. A total number of thirty-six students (6 students X 6 schools were selected, andtheir videotaped motor behavior in the lessons was analyzed with the Academic Learning Time ¿ Physical Education (ALT-PE,Parker, 1989. Regression analysis was applied to calculate students´ residual scores of achievement and to enable further data analysis. Correlation analysis between students´ achievement and ALT-PE categories indicated significant relationships between skill acquisition, learning and ALT-PE categories. It can be concluded that time devoted to practice skills, unlike times pent on activities irrelevant to the instructional task oron games, contributes to skill learning.ResumenEn este trabajo se estudia la relación entre variables temporales de las clases de Educación Física y la adquisición y aprendizaje de habilidades motrices fundamentales. En él participaron ciento diez alumnos de primer grado y seis profesores de Educación Física de Grecia. Los alumnos fueron examinados antes, durante y después tanto en términos cuantitativos como cualitativos en cuanto a lanzamientos y recepciones por encima de la cabeza. Se utilizó el Test de Desarrollo Motor Grueso (Ulrich, 1985 para evaluar el rendimiento en habilidades cualitativas y

Editorial: a new direction for ALT-J

Directory of Open Access Journals (Sweden)

Gráinne Conole

2003-12-01

Full Text Available The Association for Learning Technology celebrated its tenth anniversary this year and it can now be said that learning technology is a recognized research field, with a growing body of researchers and associated conferences and journals. Over the past two years as an editorial team we have undertaken a review of the position of ALT-J in relation to other journals in the area and considered the nature and scope of the papers we publish. We continue to expand our list of referees and have provided them with more detailed review forms to help guide them when considering recommendations on submissions and to encourage detailed, critical (and hopefully! helpful feedback to authors. We would like to take this opportunity to thank all the referees for their involvement and commitment to the journal and for their continued work on refereeing papers. As part of the review process we will be moving to a new publisher, Taylor and Francis, commencing with Volume 12; this is, in part, driven by a desire to increase our international profile and readership, as well as seeking to have a better online presence including electronic access to all papers. We are, after all, a research journal on learning technologies! We are looking forward to taking the journal forward with Taylor and Francis but would also like to take this opportunity to thank our current publisher, University of Wales Press, for all their support and professional work over the years; it has been very good working with them.

Altıntop Dilim Konservesi Üretiminde Enzim Kullanımı: I. Kabuk Soyma

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Osman Kola

2015-02-01

Full Text Available Bu çalışmada; altıntop dilim konservesi yapımında kabuk soyma ve dilim zarının uzaklaştırılması amaçlarıyla enzim çözeltisi kullanılmasının etkileri araştırılmıştır. Bunun için: önce, çözeltinin meyve kabuğu içine nüfuz ettirilmesi amacıyla uygulanabilecek uygun işlemler, sonra da, enzim çözeltisi uygulamasının kabuk soyma işlemleri üzerindeki etkileri araştırılmıştır. Kabuk soyma işleminde meyvenin; 95 °C sıcaklıktaki suda 5 dakika bekletildikten sonra kapak açma ve kabuk çizme işlemlerini takiben, su ya da %0.5 düzeyindeki Peelzym II çözeltisi içine konulan meyvelerin 1.76 kg/cm2 (25 psi basınç altında 60 saniye süreyle işleme tabi tutulmasının, hem işlemin etkinliği hem de son ürünün kalitesi açısından uygun olabileceği sonucuna varılmıştır.

CASUÍSTICA DE ALTE NUM HOSPITAL TERCIÁRIO – O QUE MUDOU NOS ÚLTIMOS 5 ANOS?

Directory of Open Access Journals (Sweden)

Daniel Meireles

2016-07-01

Conclusões: O ALTE cursa frequentemente com evolução favorável. Apesar de não haver recomendação ou consensos na literatura para a investigação etiológica, esta mantém-se uma prática comum, sem aparente modificação na abordagem nos últimos anos, em comparação com estudo prévio realizado em 2009.

Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research.

Science.gov (United States)

Scully, Peter; Zhao, Jie; Ba, Sujuan

2016-02-03

The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)--a leading cancer research charitable organization in the United States that is committed to supporting scientific research and public education relating to the prevention, early diagnosis, better treatments, and ultimately, a cure for cancer. Each year, the Szent-Györgyi Prize honors an outstanding researcher, nominated by colleagues or peers, who has contributed outstanding, significant research to the fight against cancer, and whose accomplishments have helped improve treatment options for cancer patients. The Prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the pioneering work led by the 2015 Prize winner, Dr. Frederick Alt. Dr. Alt's work in the area of cancer genetics over four decades has helped to shape the very roots of modern cancer research. His work continues to profoundly impact the approaches that doctors around the globe use to diagnose and treat cancer. In particular, his seminal discoveries of gene amplification and his pioneering work on molecular mechanisms of DNA damage repair have helped to usher in the era of genetically targeted therapy and personalized medicine.

Synthesis and properties of the metallo-supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO3: Ag+/Cu2+ ion exchange and effective antibacterial activity

KAUST Repository

Xu, Feng

2014-01-01

The commercial polymeric anhydride poly(methyl vinyl ether-alt-maleic anhydride) (PVM/MA) is converted by reaction with NaOH to give poly(methyl vinyl ether-alt-mono-sodium maleate) (PVM/Na-MA). By addition of AgNO 3-solution, the formation of the silver(i) supramolecular polymer hydrogel poly[methyl vinyl ether-alt-mono-sodium maleate]·AgNO 3 is reported. Freeze-dried samples of the hydrogel show a mesoporous network of polycarboxylate ligands that are crosslinked by silver(i) cations. In the intact hydrogel, ion-exchange studies are reported and it is shown that Ag+ ions can be exchanged by copper(ii) cations without disintegration of the hydrogel. The silver(i) hydrogel shows effective antibacterial activity and potential application as burn wound dressing. © the Partner Organisations 2014.

Gilthead seabream (Sparus aurata) response to three music stimuli (Mozart--"Eine Kleine Nachtmusik," Anonymous--"Romanza," Bach--"Violin Concerto No. 1") and white noise under recirculating water conditions.

Science.gov (United States)

Papoutsoglou, Sofronios E; Karakatsouli, Nafsika; Psarrou, Anna; Apostolidou, Sofia; Papoutsoglou, Eustratios S; Batzina, Alkisti; Leondaritis, Georgios; Sakellaridis, N

2015-02-01

This study presents the results of the response of Sparus aurata to three different musical stimuli, derived from the transmission (4 h per day, 5 days per week) of particular music pieces by Mozart, Romanza and Bach (140 dB(rms) re 1 μPa), compared to the same transmission level of white noise, while the underwater ambient noise in all the experimental tanks was 121 dB(rms) re 1 μPa. Using recirculating sea water facilities, 10 groups, 2 for each treatment, of 20 specimens of 11.2 ± 0.02 g (S.E.), were reared for 94 days, under 150 ± 10 l× 12L-12D, and were fed an artificial diet three times per day. Fish body weight showed significant differences after 55 days, while its maximum level was observed after the 69th day until the end of the experiment, the highest value demonstrated in Mozart (M) groups, followed by those of Romanza (R), Bach (B), control (C) and white noise (WN). SGR (M = B), %WG (M = B) and FCR (all groups fed same % b.w.) were also improved for M group. Brain neurotransmitters results exhibited significant differences in DA-dopamine, (M > B), 5HIAA (C > B), 5HIAA:5HT (WN > R), DOPAC (M > B), DOPAC:DA and (DOPAC + HVA):DA, (C > M), while no significant differences were observed in 5HT, NA, HVA and HVA:DA. No differences were observed in biometric measurements, protease activity, % fatty acids of fillet, visceral fat and liver, while differences were observed regarding carbohydrase activity and the amount (mg/g w.w.) of some fatty acids in liver, fillet and visceral fat. In conclusion, present results confirm those reported for S. aurata, concerning the observed relaxing influence--due to its brain neurotransmitters action--of the transmission of Mozart music (compared to R and B), which resulted in the achievement of maximum growth rate, body weight and improved FCR. This conclusion definitely supports the musical "understanding" and sensitivity of S. aurata to music stimuli as well as suggesting a specific effect of white noise.

Performances and first experimental results of BACH, the beamline for dichroism and scattering experiments at ELETTRA

International Nuclear Information System (INIS)

Zangrando, M.; Zacchigna, M.; Bondino, F.; Finazzi, M.; Pardini, T.; Plate, M.; Rochow, R.; Cocco, D.; Parmigiani, F.

2004-01-01

BACH, the new soft x-ray beamline for polarization dependent experiments at the Italian synchrotron radiation facility ELETTRA, has been commissioned, characterized and opened to external users. Based on two APPLE II undulators, it covers an energy range between 35 eV and 1600 eV with the control of the light polarization. The monochromator works either in high resolution or high flux mode. Resolving powers of 16000 at 50 eV, 12000 at 90 eV, more than 12000 at 400 eV, 15000 at 534 eV and 6600 at 867 eV have been achieved with the three high resolution gratings. The resolving powers of the high flux grating, which covers the 290 - 1600 eV range, have been measured reaching 7000 at 400 eV and 2200 at 867 eV. The fluxes, in the high resolution mode, range between 4·1011 photons/s at 125 eV and 2·1010 photons/s at about 1100 eV. Using the high flux grating with the best resolution achievable 1.7·1011 photons/s impinge on the sample at 900 eV. Two branches are installed after the monochromator allowing the set-up of two different experimental stations. One of them, besides several facilities for surface preparation and analysis, hosts a compact inelastic soft x-ray spectrometer (ComIXS) dedicated to x-ray emission experiments exploiting the small spot (10 μm in the vertical direction) on the sample. The other branch hosts a liquid helium cryostat equipped with a superconducting coil to perform absorption and transmission experiments with temperatures down to 2 K and magnetic field up to ±7 T

Seasonal variability of cohesive sediment aggregation in the Bach Dang-Cam Estuary, Haiphong (Vietnam)

Science.gov (United States)

Lefebvre, Jean-Pierre; Ouillon, Sylvain; Vinh, Vu Duy; Arfi, Robert; Panché, Jean-Yves; Mari, Xavier; Van Thuoc, Chu; Torréton, Jean-Pascal

2012-04-01

In the Bach Dang-Cam Estuary, northern Vietnam, mechanisms governing cohesive sediment aggregation were investigated in situ in 2008-2009. As part of the Red River delta, this estuary exhibits a marked contrast in hydrological conditions between the monsoon and dry seasons. The impact on flocculation processes was assessed by means of surveys of water discharge, suspended particulate matter concentration and floc size distributions (FSDs) conducted during a tidal cycle at three selected sites along the estuary. A method was developed for calculating the relative volume concentration for the modes of various size classes from FSDs provided by the LISST 100X (Sequoia Scientific Inc.). It was found that all FSDs comprised four modes identified as particles/flocculi, fine and coarse microflocs, and macroflocs. Under the influence of the instantaneous turbulent kinetic energy, their proportions varied but without significant modification of their median diameters. In particular, when the turbulence level corresponded to a Kolmogorov microscale of less than ˜235 μm, a major breakup of flocs resulted in the formation of particles/flocculi and fine microflocs. Fluctuations in turbulence level were governed by seasonal variations in freshwater discharge and by the tidal cycle. During the wet season, strong freshwater input induced a high turbulent energy level that tended to generate sediment transfer from the coarser size classes (macroflocs, coarse microflocs) to finer ones (particles/flocculi and fine microflocs), and to promote a transport of sediment seawards. During the dry season, the influence of tides predominated. The turbulent energy level was then only episodically sufficiently high to generate transfer of sediment between floc size classes. At low turbulent energy, modifications in the proportions of floc size classes were due to differential settling. Tidal pumping produced a net upstream transport of sediment. Associated with the settling of sediment

Epigenetic silencing of BTB and CNC homology 2 and concerted promoter CpG methylation in gastric cancer.

Science.gov (United States)

Haam, Keeok; Kim, Hee-Jin; Lee, Kyung-Tae; Kim, Jeong-Hwan; Kim, Mirang; Kim, Seon-Young; Noh, Seung-Moo; Song, Kyu-Sang; Kim, Yong Sung

2014-09-01

BTB and CNC homology 2 (BACH2) is a lymphoid-specific transcription factor with a prominent role in B-cell development. Genetic polymorphisms within a single locus encoding BACH2 are associated with various autoimmune diseases and allergies. In this study, restriction landmark genomic scanning revealed methylation at a NotI site in a CpG island covering the BACH2 promoter in gastric cancer cell lines and primary gastric tumors. Increased methylation of the BACH2 promoter was observed in 52% (43/83) of primary gastric tumors, and BACH2 hypermethylation was significantly associated with decreased gene expression. Treatment with 5-aza-2'-deoxycytidine and/or trichostatin. A restored BACH2 expression in BACH2-silenced gastric cancer cell lines, and knockdown of BACH2 using short hairpin RNA (i.e. RNA interference) increased cell proliferation in gastric cancer cells. Clinicopathologic data showed that decreased BACH2 expression occurred significantly more frequently in intestinal-type (27/44, 61%) compared with diffuse-type (13/50, 26%) gastric cancers (P<0.001). Furthermore, BACH2 promoter methylation paralleled that of previously identified targets, such as LRRC3B, LIMS2, PRKD1 and POPDC3, in a given set of gastric tumors. We propose that concerted methylation in many promoters plays a role in accelerating gastric tumor formation and that methylated promoter loci may be targets for therapeutic treatment, such as the recently introduced technique of epigenetic editing. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Changes of serum levels of prealbumin (PAB), cholinesterase (CHE), total bile acid (TBA) and ALT as related to the severity of inflammatory process and hepatic fibrosis in patients with chronic virus B hepatitis

International Nuclear Information System (INIS)

Chi Xiaoxia; Chen Jianxiong; Xiong Ying

2005-01-01

Objective: To study the correlationship between the serum levels of PAB, CHE, TBA, ALT and the severity of the disease process in patients with chronic virus B hepatitis. Methods: Serum levels of PAB, CHE, ALT (with biochemical methods) and TBA (with RIA) were examined in 93 patients with biopsy proven virus B hepatitis and 46 controls. Results: The 93 patients were of two groups: a less advanced group (n=51) and a more advanced group (n=42). Serum TBA, ALT levels were significnatly higher and serum PAB, CHE levels were significantly lower in the more advanced group than those in the less advanced group (P 0 to s 4 . Changes of levels of ALT were of no regular pattern, but serum levels of TBA regularly increased and levels of PAB, CHE regularly decreased as the fibrosis grading proceeded from s 0 to s 4 and the differences between the levels in s 4 and any other grading were significant (P<0.01). Conclusion: Combined determination of these serum markers might reflect the degree of inflammatory process and hepatic fibrosis in patients with virus B hepatitis, leading to earlier detection of cirrhosis. (authors)

Wolfgang Bargmann (1906-1978) and Heinrich von Hayek (1900-1969): careers in anatomy continuing through German National Socialism to postwar leadership.

Science.gov (United States)

Hildebrandt, Sabine

2013-07-01

None of the existing studies on the history of anatomy in National Socialism (NS) has yet explored the careers of those younger anatomists, whose professional development continued through NS times and who attained prominence in postwar German and Austrian anatomy. As they became modern anatomists' teachers and role models, the revelation that men like Wolfgang Bargmann and Heinrich von Hayek had used bodies of the executed for research in their early careers has recently led to some consternation. This study contributes to the analysis of the moral challenges inherent to a science that relies on work with "material" from human bodies and its interaction with its political environment. The results reveal that Bargmann and Hayek behaved like most other anatomists at the time, in that they used bodies of the executed for research and in that they joined the NS party or other NS political groups. As ambitious and successful young anatomists they may have felt that an early joining of NS affiliations was inevitable for the advancement of their careers. They and most of their colleagues became in some measure complicit with the NS regime. The complicated biographical realities of such luminous postwar figures as Bargmann and Hayek should lead modern anatomists to the questioning of their own ethical and political decisions in politically less demanding times. Copyright © 2013 Elsevier GmbH. All rights reserved.

Melting experiments and field work on Komorní Hùrka volcano, Bohemia, by Johann Wolfgang von Goethe

Science.gov (United States)

Horn, Susanne; Kreher-Hartmann, Birgit; Heide, K.

2001-09-01

Johann Wolfgang von Goethe (1749-1832), eminent author, was also state minister and scientist as well as experimentalist in geology. Together with Döbereiner, a chemist in Jena during that time, he carried out melting experiments in porcelain and pottery kilns with rocks and minerals from the volcanic and pseudo-volcanic edifices in NW Bohemia. These experiments were to prove Goethe's theory, that remelting of an archetype rock would result in volcanic and pseudo-volcanic rocks. Especially the formation of the Komorní Hùrka (Kammerberg) volcano in NW Bohemia attracted Goethe during all his life. He visited this location 19 times in 1808, 1820 and 1822 and made very exact field observations. But the interpretation of these observations varied between volcanistic and neptunistic. In order to find arguments, he examined the effect of fire on rocks and minerals using porcelain and pottery kilns. The experiments did not provide the expected results and thus failed to explain the formation of Komorní Hùrka. During Goethe's geognostic work, including the "pyro-technical" experiments, the neptunism-volcanism-controversy about the formation of basalt raged in Europe, and, more general, about rock formation: neptunism-plutonism. Especially the effect of heat on rocks and minerals, i.e. the phenomenology of fire, played an important role in that discussion. Goethe swayed during his lifetime between neptunism and volcanism. He did not fully accept plutonism because he believed, that processes of nature are generally non-violent and that volcanic eruptions and other catastrophic phenomena are the exception rather than the rule. Therefore he tended to neptunistic ideas. In Goethe's notes there are many indications of this conflict. In contrast, the melting experiments are mentioned only few times. It was, however, possible to establish a picture of his experimental work and his fundamental concepts and ideas.

Multifunctional e-spun colloidal nanofiber structures from various dispersed blends of PVA/ODA-MMT with PVP/ODA-MMT, poly(VP-alt-MA and AgNPs incorporated polymer complexes as electro-active platforms

Directory of Open Access Journals (Sweden)

U. Bunyatova

2016-07-01

Full Text Available This work presented a new approach to fabricate polymer nanocomposites films with nanofiber structures from solution blends of poly(vinyl alcohol + octadecyl amine-montmorillonite (ODA-MMT (matrix with poly(N-vinylpyrrolidone + ODA-MMT (partner-1, poly(N-vinylpyrrolidone-alt-maleic anhydride ((poly(VP-alt-MA + (ODA-MMT (partner-2 and their silver (Ag-carrying polymer complexes by electrospinning. Chemical and physical structures, surface morphologies, thermal behaviors, electrical conductivity and thermal resistance parameters of nanofiber structures were investigated. Poly(VP-alt-MA was used both as a crosslinker and a donor of the hydrophilic groups such as ‒COOH and ‒NH–C=O amide from pyrrolidone ring. Reactive poly(VP-alt-MA, in situ generated Ag nanoparticles (AgNPs and original partner polymer had an significant effect on the morphology and diameter distribution of nanofibers. High and excellent conductive behaviors were observed for the homopolymer and copolymer of VP based fiber structures, respectively. Upon successive chemical cross-linking of the nanofiber structures by reactive partner copolymer, the conductivity of nanofiber films as electro-active platforms dramatically increased to 3.90·10–2 S·cm–1 at room temperature. Comparative analysis results also indicated that electrical properties strongly depended on the loaded reactive organoclay and in situ generated AgNPs.

Frequent downregulation of BTB and CNC homology 2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Science.gov (United States)

Noujima-Harada, Mai; Takata, Katsuyoshi; Miyata-Takata, Tomoko; Sakurai, Hiroaki; Igarashi, Kazuhiko; Ito, Etsuro; Nagakita, Keina; Taniguchi, Kohei; Ohnishi, Nobuhiko; Omote, Shizuma; Tabata, Tetsuya; Sato, Yasuharu; Yoshino, Tadashi

2017-05-01

Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell lymphoma subtype, and the Epstein-Barr virus (EBV)-positive subtype of DLBCL is known to show a more aggressive clinical behavior than the EBV-negative one. BTB and CNC homology 2 (BACH2) has been highlighted as a tumor suppressor in hematopoietic malignancies; however, the role of BACH2 in EBV-positive DLBCL is unclear. In the present study, BACH2 expression and its significance were studied in 23 EBV-positive and 43 EBV-negative patient samples. Immunohistochemistry revealed BACH2 downregulation in EBV-positive cases (P < 0.0001), although biallelic deletion of BACH2 was not detected by FISH. Next, we analyzed the contribution of BACH2 negativity to aggressiveness in EBV-positive B-cell lymphomas using FL-18 (EBV-negative) and FL-18-EB cells (FL-18 sister cell line, EBV-positive). In BACH2-transfected FL-18-EB cells, downregulation of phosphorylated transforming growth factor-β-activated kinase 1 (pTAK1) and suppression in p65 nuclear fractions were observed by Western blot analysis contrary to non-transfected FL-18-EB cells. In patient samples, pTAK1 expression and significant nuclear p65, p50, and p52 localization were detected immunohistochemically in BACH2-negative DLBCL (P < 0.0001, P = 0.006, and P = 0.001, respectively), suggesting that BACH2 downregulation contributes to constitutive activation of the nuclear factor-κB pathway through TAK1 phosphorylation in BACH2-negative DLBCL (most EBV-positive cases). Although further molecular and pathological studies are warranted to clarify the detailed mechanisms, downregulation of BACH2 may contribute to constitutive activation of the nuclear factor-κB pathway through TAK1 activation. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Influence of the composition of hydroxypropyl cellulose/maleic acid-alt-styrene copolymer blends on their properties as matrix for drug release

Directory of Open Access Journals (Sweden)

2009-05-01

Full Text Available Poly(carboxylic acid-polysaccharide compositions have been found suitable for obtaining drug formulations with controlled release, most formulations being therapeutically efficacious, stable, and non-irritant. The influence of the characteristics of the aqueous solutions from which the polymer matrix is prepared (i.e. the total concentration of polymer in solutions and the mixing ratio between the partners, hydroxypropyl cellulose, HPC and maleic acid-alternating-styrene copolymer, MAc-alt-S on the kinetics of some drugs release in acidic environment (pH = 2 has been followed by ‘in vitro’ dissolution tests. It has been established that the kinetics of procaine hydrochloride release from HPC/MAc-alt-S matrix depends on its composition; the diffusion exponent, n is close to 0.5 for matrices where one of the components is in large excess and n~0.02 for middle composition range. The lower value of diffusion exponent for middle composition range could be caused by the so called ‘burst effect’, therefore the kinetic evaluation is difficult.

Feedback on the Inaugural Meeting of the Cost 347 Accelerated Loading Test (ALT) Action in Europe: June 27th to 29th 2001

CSIR Research Space (South Africa)

De Beer, Morris

2001-11-01

Full Text Available . The author presented two topics, i.e. Accelerated Pavement Testing (APT) in South Africa, and Stress-In-Motion (SIM). This COST 347 action started in October 2001, and needs to deliver recommendations on ALT April 2004. There are 6 Working Groups, chaired...

Synthesis of electro-optically active polymer composite of poly[2,2'-bis(3,4-ethylenedioxythiophene-alt-fluorene]/hydroxypropyl cellulose showing liquid crystal structure

Directory of Open Access Journals (Sweden)

N. Eguchi

2017-10-01

Full Text Available Electrochemical preparation of a composite consisting of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] and hydroxypropyl cellulose (PEFE/HPC was carried out. We conducted electrochemical polymerization of poly[2,2′-bis(3,4-ethylenedioxythiophene-alt-fluorene] (EFE as a monomer in a lyotropic liquid crystal of HPC. We used an organic solvent instead of water for lyotropic liquid crystal medium to expand the possibility of the range of monomers, although water is usually employed as a solvent for HPC for showing liquid crystallinity. Here, we employed N,N-dimethylformamide (DMF as a solvent for HPC. Electrochemical polymerization in the polymer liquid crystal was carried out to obtain a polymer film with liquid crystal order. The polymer film thus prepared exhibited optical activity. Fourier transfer infrared (FT-IR absorption spectroscopy reveals that the film is a composite consisting of HPC and polymer. The composite PEFE/HPC thus prepared in HPC/DMF system showed electrochromism.

[The influence of music on pictorial expression of young women--a comparative study of different music styles].

Science.gov (United States)

Schiltz, L; Maugendre, M; Brytek-Matera, A

2010-01-01

Questing one's personal identity and developing a coherent representation of oneself, the other and the world are major tasks in adolescence. Research showed that a satisfactory resolution of the crisis of adolescence can be favoured by psychological counselling based on artistic mediations. The objective of this study consisted in exploring the effect of music on the pictorial expression of a non clinical sample of female adolescents (N=157) aged from 17 to 28 years. We analysed free drawings realised by the test group with the help of a rating scale constructed in a phenomenological and structural perspective (Schiltz, 2006). The adolescents painted under musical induction. We proposed three different styles of music, i.e. baroque music (Georg Friedrich Händel and Johann Sebastian Bach), classical music (Wolfgang Amadeus Mozart and Ludwig van Beethoven) and polish ethnical music (Kapela ze Wsi Warszawa-Warsaw Village Band). By using non parametric inferential and multi dimensional statistics, we could show that structural characteristics of music styles lead to differences in formal and content variables on the rating scales for the pictures. The results of our exploratory study open some tracks for future research. It would be pertinent to enlarge the population to other categories of age and to investigate the influence of gender.

Application of intensity modulated radiation therapy for the cancer patients treatment in Bach Mai Hospital

International Nuclear Information System (INIS)

Mai Trong Khoa; Tran Dinh Ha; Le Chinh Dai; Nguyen Quang Hung; Vu Huu Khiem

2011-01-01

Intensity modulated radiotherapy (IMRT) is one of the modern techniques in cancer treatment, in which dose is delivered optimally into the shape of the tumor and minimally in surround benign tissues. In developed countries, this technique has been performed routinely by Linacs with MLC for tumors at the critical areas. In Vietnam, because of the wet climate, the use of Linacs with MLC is difficult to operate and maintain. However, IMRT can be implemented by Linacs without MLC via independent jaws, Jaws-only IMRT (JO-IMRT), in which beams are separated into many segments with different weights to optimize highest dose in the tumor and lowest dose in the surrounding health organs. Methods: We describe the new treatment technic application and compare it with normal radiotherapy method (3D-CRT). Results: From 7/2008, the Dep of Nuclear Medicine and Oncology at Bach Mai Hospital has been conducting JO-IMRT to treat cancer patients. Up to now, we have 81 cases treated by IMRT including head and neck cancers (NPC, larynx cancer, maxillary sinus cancer, brain tumor), cancers in the thorax (esophagus cancer, lung cancer, breast cancer), cancers in the pelvis (prostate cancer, cervical cancer, rectal cancer). On the average, beam number is from 5 to 9 and 5-9 segments per beam. Treatment time for a fraction is from 6 to 12 minutes with 2.25 Gy for CTV1 per day. Discrepancies of doses were below 3% (0.15 to 2.84%) between planning and practice. In plan, the preeminences with IMRT are clearly superior to 3D radiation therapy. In clinical, almost patients had good respond, whereas side effects were quite less than conventional radiotherapy. Conclusions: JO-IMRT is a modern technic with more advantage than normal 3D-CRT. It help radiation dose to concentrate maximally in treatment target while influence minimally for sensitive surrounding tissues. Another, it is a high technic to appropriate with the climatic condition in Vietnam. (author)

PARÁMETROS BIOQUÍMICOS ENZIMÁTICOS (ALT, AST, ALP, Γ-GT, LDH EN NIÑOS CON LEUCEMIA LINFOBLÁSTICA AGUDA ANTES DEL TRATAMIENTO ANTINEOPLÁSICO

Directory of Open Access Journals (Sweden)

Jeél Moya S

2015-12-01

Full Text Available Objective: To determine the enzymatic biochemical parameters (glutamic pyruvic transaminase (ALT, glutamic oxaloacetic transaminase (AST, alkaline phosphatase (ALP, gamma glutamyltransferase (γ-GT, and lactate dehydrogenase (LDH in children with acute lymphoblastic leukemia (ALL before cancer treatment. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Blood collection was performed in BD red cap Vacutainer tubes, processed in the semi-automated analyzer BIOTEC® EMP-168, with Wiener Lab Group enzyme reagents under the modified method Szaaz and UV-Optimized by IFCC, SSCC and SFBC. Finally, coding and tabulation was performed. Results: 60% were boys and 46.7% are between the ages of 2-6 years. Serum levels of AST were increased by 33.3% in boys and 50% in girls. Serum ALT values were increased in 33.3% of boys and 41.7% of girls; only 25% of girls showed increased levels of γ-GT values; ALP was increased in 44.4% of boys and 66.7% of girls. Moreover LDH levels were increased in 55.6% of boys and 41.7% of girls. Conclusions: The enzymatic tests LDH, AST, ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements.

Side effects of different pesticides used in citrus on the adult stage of the parasitoid Aphytis melinus DeBach (Hymenoptera Aphelinidae and its progeny

Directory of Open Access Journals (Sweden)

J. E. Gonzalez-Zamora

2013-05-01

Full Text Available Twelve pesticides commonly used in citrus in Spain were tested on adults of Aphytis melinus DeBach to determine their effects on parasitoid survival and fecundity, and the duration of the residue of each pesticide. Six of these pesticides were found to be harmless to moderately harmful to this parasitoid in a laboratory assay in closed Petri dishes: spinosad (bait formulation, azadirachtin, fenbutatin, fosetyl-Al, copper oxichloride, and mancozeb, with their scores on the reduction of beneficial capacity (RBC index being between 21.4 and 94.6% after one week. The other six pesticides classified as harmful were tested on citrus plants to study their persistence over time under greenhouse conditions: Pirimicarb, pyriproxifen, paraffinic oil, abamectin, chlorpyrifos, and lambda-cyhalothrin. Most of these products reduced their negative effect on adults of A. melinus between one and six weeks after treatment, although lambda-cyhalothrin was still harmful to parasitoids 11 weeks after application. This information can help growers and consultants to make decisions about pesticide selection and application timing in citrus in order to support IPM implementation when A. melinus is present.

Politiken, Alt om Ikast Brande (web), Lemvig Folkeblad (Web), Politiken (web), Dabladet Ringkjøbing Skjern (web)

DEFF Research Database (Denmark)

Lauritsen, Jens

2014-01-01

Politiken 01.01.2014 14:16 Danskerne skød nytåret ind med et brag, men for enkeltes vedkommende gik det galt, da nytårskrudtet blev tændt. Skadestuerne har behandlet 73 personer for fyrværkeriskader mellem klokken 18 i aftes og klokken 06 i morges. Det viser en optælling, som Politiken har...... foretaget på baggrund af tal fra Ulykkes Analyse Gruppen på Odense Universitetshospital. Artiklen er også bragt i: Alt om Ikast Brande (web), Lemvig Folkeblad (web), Politiken (web), Dagbladet Ringkjøbing Skjern (web)....

Cueing musical emotions: An empirical analysis of 24-piece sets by Bach and Chopin documents parallels with emotional speech.

Science.gov (United States)

Poon, Matthew; Schutz, Michael

2015-01-01

Acoustic cues such as pitch height and timing are effective at communicating emotion in both music and speech. Numerous experiments altering musical passages have shown that higher and faster melodies generally sound "happier" than lower and slower melodies, findings consistent with corpus analyses of emotional speech. However, equivalent corpus analyses of complex time-varying cues in music are less common, due in part to the challenges of assembling an appropriate corpus. Here, we describe a novel, score-based exploration of the use of pitch height and timing in a set of "balanced" major and minor key compositions. Our analysis included all 24 Preludes and 24 Fugues from Bach's Well-Tempered Clavier (book 1), as well as all 24 of Chopin's Preludes for piano. These three sets are balanced with respect to both modality (major/minor) and key chroma ("A," "B," "C," etc.). Consistent with predictions derived from speech, we found major-key (nominally "happy") pieces to be two semitones higher in pitch height and 29% faster than minor-key (nominally "sad") pieces. This demonstrates that our balanced corpus of major and minor key pieces uses low-level acoustic cues for emotion in a manner consistent with speech. A series of post hoc analyses illustrate interesting trade-offs, with sets featuring greater emphasis on timing distinctions between modalities exhibiting the least pitch distinction, and vice-versa. We discuss these findings in the broader context of speech-music research, as well as recent scholarship exploring the historical evolution of cue use in Western music.

Incontri di Fisica delle Alte Energie Italian Meeting on High Energy Physics Napoli

CERN Document Server

Carlino, Gianpaolo; Merola, Leonardo; Paolucci, Pierluigi; Ricciardi, Giulia; IFAE 2007

2008-01-01

This book collects the Proceedings of the Workshop "Incontri di Fisica delle Alte Energie (IFAE) 2007, Napoli, 11-13 April 2007". This is the sixth edition of a series of meetings on fundamental research in particle physics and was attended by about 160 researchers. Presentations, both theoretical and experimental, addressed the status of Physics of the Standard Model and beyond, Flavour phyisc, Neutrino and Astroparticle physics, new technology in high energy physics. Special emphasis was given to the expectations of the forthcoming Large Hadron Collider, due in operation at the end of 2007. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings and of the open questions in this extremely challenging cultural field. The venue of plenary sessions interleaved with parallel ones allowed for a rich exchange of ideas, presented in these Proceedings, that form a coherent picture of the findings ...

78 FR 19568 - Limited Service Exclusion for Household Goods Motor Carriers and Related Registration...

Science.gov (United States)

2013-04-01

.... Example A Bach's Movers, a container company, advertises itself as ``The Lowest Cost Moving Option'' on its company Web site. The Web site has a link to ``XYZ Moving Helpers'' and recommends that Bach's... XYZ pays Bach's a 3 percent referral fee for every customer that contracts with XYZ after visiting...

Twist-3 effect from the longitudinally polarized proton for ALT in hadron production from pp collisions

Directory of Open Access Journals (Sweden)

Yuji Koike

2016-08-01

Full Text Available We compute the contribution from the longitudinally polarized proton to the twist-3 double-spin asymmetry ALT in inclusive (light hadron production from proton–proton collisions, i.e., p↑p→→hX. We show that using the relevant QCD equation-of-motion relation and Lorentz invariance relation allows one to eliminate the twist-3 quark-gluon correlator (associated with the longitudinally polarized proton in favor of one-variable twist-3 quark distributions and the (twist-2 transversity parton density. Including this result with the twist-3 pieces associated with the transversely polarized proton and unpolarized final-state hadron (which have already been calculated in the literature, we now have the complete leading-order cross section for this process.

Plasma influence on throat conductance of the TEXTOR pump limiter ALT-I

International Nuclear Information System (INIS)

Hardtke, A.; Finken, K.H.; Reiter, D.; Dippel, K.H.; Goebel, D.M.; McGrath, R.T.; Sagara, A.

1989-01-01

On the TEXTOR pump limiter ALT-I conductance measurements for the backstreaming of gas from the pump limiter vessel through the pump limiter entrance have been performed. In these experiments neutral gas has been injected into the pump limiter plenum during a short pulse. The influence of the instreaming plasma results in a reduction of the conductance of the outstreaming gas. For helium the conductance is reduced to about 40% of the molecular conductance when a plasma flux of 0.8 A/cm 2 (T e =T i =11 eV) is streaming into the pump limiter throat. The reduction of the conductance for backstreaming hydrogen and deuterium under the same plasma conditions is smaller; about 70% of the molecular conductance is obtained. This reduction can be explained by an increased recycling of ions which have been produced in the throat back to the neutralizer plate. The experimental results can be reproduced by Monte Carlo neutral transport code calculations if the recycling coefficient is about 0.85 for hydrogen and deuterium and about 0.95 for helium ions. Processes causing these high recycling coefficients are discussed and their influence is estimated. (orig.)

[Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands. Der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer] / Madis Maasing

Index Scriptorium Estoniae

Maasing, Madis, 1984-

2014-01-01

Arvustus: Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands. Der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer

LIMITED ELEVATIONS IN ANTITUBERCULOSIS DRUG-INDUCED SERUM ALANINE AMINOTRANSFERASE (ALT) LEVELS IN A COHORT OF NIGERIANS ON TREATMENT FOR PULMONARY TUBERCULOSIS AND HIV INFECTION IN YENAGOA

NARCIS (Netherlands)

Ikuabe, Peter Ogie; Ebuenyi, Ikenna Desmond; Harry, Tubonye Clement

2015-01-01

BACKGROUND: This study, undertaken in a major tertiary hospital in the Niger Delta region of Nigeria was designed to examine the incidence of elevation in serum alanine aminotransference (ALT) in our patients who were on treatment for HIV/AIDS with some of them on antituberculosis drugs. METHOD:

The Iberian hamlet of L’Alt del Punxó: agricultural production and peasant settlement in central Contestania | La aldea ibérica de L’Alt del Punxó: producción agrícola y asentamiento campesino en el área central de la Contestania

Directory of Open Access Journals (Sweden)

Israel Espí Pérez

2009-12-01

Full Text Available In this paper we describe an Iberian Iron Age village recently excavated as a result of the construction of a new motorway through Muro de l’Alcoi (El Comtat, Alicante province, Spain. The hamlet consists of huts, agricultural buildings and a paved road dating to between the seventh and fourth centuries BC. L’Alt del Punxó has significantly advanced our knowledge of Iberian settlement patterns and the organisation of economic activity in this area. An integrated analysis of the evidence furnished by the fieldwork increases our knowledge of different aspects of the social and economic organization of Iberian Iron Age populations in central Contestania. | En este trabajo damos a conocer un hábitat rural de época ibérica excavado con motivo de recientes obras de construcción de la Autovía del Mediterráneo a su paso por la localidad de Muro de l’Alcoi (El Comtat, Alacant. La aldea está conformada por cabañas, instalaciones de procesamiento agrícola y un camino empedrado que se datan entre los ss. VII y IV aC. L’Alt del Punxó ha permitido un considerable avance en el conocimiento de las formas de ocupación rural y articulación de la actividad económica de este territorio ibérico. La lectura integrada de la documentación permite abordar distintas cuestiones de la organización económica y social de los grupos ibéricos del área central de la Contestania.

Contemporary suspended sediment yield of a partly glaciated catchment, Riffler Bach (Tyrol, Austria)

Science.gov (United States)

Weber, Martin; Baewert, Henning; Morche, David

2015-04-01

Due to glacier retreat since the LIA (Little Ice Age) proglacial areas in high mountain landscapes are growing. These systems are characterized by a high geomorphological activity, especially in the fluvial subsystem. Despite the long tradition of geomorphological research in the European Alps there is a still a lack of understanding in the interactions between hydrology, sediment sources, sediments sinks and suspended sediment transport. As emphasized by ORWIN ET AL. (2010) those problems can be solved by gathering data in a higher frequency and/or in a higher spatial resolution or density - both leading to a big amount of data. In 2012 a gauging station was installed at the outlet of the partly glaciated catchment of the Riffler Bach (Kaunertal valley, Tyrol). During the ablation seasons in 2012 and 2013 water stage was logged automatically every 15 minutes. In both seasons discharge was measured at different water levels to calculate a stage-discharge relation. Additionally, water samples were taken by an automatic water sampler. Within 16 sampling cycles with sampling frequencies ranging from 1 to 24 hours 389 water samples have been collected. The samples were filtered to calculate the suspended sediment concentration (SSC) of each sample. Furthermore, the climate station Weißsee provided meteorological data at a 15 minute interval. Due to the high variability in suspended sediment transport in proglacial rivers it is impossible to compute a robust annual Q-SSC-relation. Hence, two other approaches were used to calculate the suspended sediment load (SSL) and the suspended sediment yield (SSY): A) Q-SSC-relations for every single sampling cycle (e.g. GEILHAUSEN ET AL. 2013) B) Q-SSC-relations based on classification of dominant runoff-generating processes (e.g. ORWIN AND SMART 2004). The first approach uses commonly operated analysis methods that are well understood. While the hydro-climatic approach is more feasible to explain discharge generation and to

Activity of Catalase (CAT, ALT and AST in Different Organs of Swiss Albino Mice Treated with Lead Acetate, Vitamin C and Magnesium-L-Threonate

Directory of Open Access Journals (Sweden)

Ilir Nazmi Mazreku

2017-11-01

Full Text Available Introduction: Lead is a natural element with toxic properties and is widespread in the environment. Lead toxicity is associated with generation of reactive oxygen and nitrogen species and consumption of antioxidants elements (vitamin E and C, glutathione, thioredoxin and lipoic acid, melatonin, carotenoids and natural flavonoids in the cell, and unbalancing oxidantsantioxidants levels. Aim: To evaluate the effects of different chemical combinations (lead acetate, Vitamin C and Magnesium-L-threonate on antioxidant enzyme activity (catalase-CAT of liver, kidney, spleen, pancreas and brain, and serum transaminases [Serum Alanine Transaminase (ALT and Serum Aspartate Transaminase (AST]. Materials and Methods: Experimental animals (49 male Mus musculus-swiss albino mice were separated into five different groups. The first group was used as a control, hence the other four groups were treated with sub-lethal doses (90 mg/kg of lead acetate (group 2, lead acetate (90 mg/kg and Vitamin C dose 40mg/kg (group 3, lead acetate (90 mg/kg and Magnesium-Lthreonate dose 100 mg/kg (group 4 and only with MagnesiumL-threonate dose 100 mg/kg (group 5, during the treatment period (40 days. Blood samples were taken from the facial vein and used for transaminase analysis. Organ tissue was collected after euthanizing anaesthetized animals with neck dislocation technique. Results: The results showed that lead acetate treatment has caused significant elevation in the activity of AST (group 2 and 3 and ALT (group 3. Also, CAT activity was significantly (p<0.05 increased in groups treated with lead acetate (liver, pancreas, kidney and brain but not in spleen. Treatment of lead intoxicated groups with Vitamin C and Magnesium L-threonate increased significantly CAT activity in brain. Conclusion: Lead effects by interacting with different molecular systems and increasing enzyme activity (CAT, ALT and AST. Effects on CAT activity of Magnesium-L-threonate and Vitamin C treatment

[Thomas Lange. Zwischen Reformation und Untergang Alt-Livlands : der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer] / Juhan Kreem

Index Scriptorium Estoniae

Kreem, Juhan, 1971-

2015-01-01

Arvustus: Lange, Thomas. Zwischen Reformation und Untergang Alt-Livlands : der Rigaer Erzbischof Wilhelm von Brandenburg im Beziehungsgeflecht der livländischen Konföderation und ihrer Nachbarländer (Hamburger Beiträge zur Geschichte des östlichen Europa)

Grafting amino drugs to poly(styrene-alt-maleic anhydride) as a potential method for drug release

Energy Technology Data Exchange (ETDEWEB)

Khazaei, Ardeshir; Saednia, Shahnaz; Saien, Javad; Abbasi, Fatemeh, E-mail: Khazaei_1326@yahoo.com, E-mail: ssaednia@gmail.com [Faculty of Chemistry, Bu-Ali Sina University, Hamedan (Iran, Islamic Republic of); Kazem-Rostami, Masoud [Young Researchers Club and Elite, Takestan Branch, Islamic Azad University, Takestan (Iran, Islamic Republic of); Sadeghpour, Mahdieh [Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan (Iran, Islamic Republic of); Borazjani, Maryam Kiani [Faculty of Science, Department of Chemistry, Bushehr Payame Noor University (PNU), Bushehr (Iran, Islamic Republic of)

2013-07-15

Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a {sup 1}H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 Degree-Sign C. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions. (author)

Probation review for lecturer

DEFF Research Database (Denmark)

Mattsson, Jan

Head of the School of Management and Business Kings College, University of London Professor Stephen Bach......Head of the School of Management and Business Kings College, University of London Professor Stephen Bach...

Carl Jung's interpretation of Wolfgang Pauli's dreams: The Bailey Island, Maine, and New York City seminars of 1936 and 1937

Science.gov (United States)

Brown, Richard Paul

This dissertation reviewed the development of Jung's dream theory and addresses the question as to whether or not Jung was influenced by the dreams of the Nobel Prize winning physicist, Wolfgang Pauli. Jung provided an extensive analysis of Pauli's dreams, which are contained in the lightly edited, unpublished transcripts of lectures delivered in 1936 and 1937. An archival and hermeneutic analysis of the texts reveals a staged process of individuation that Jung related to in many ways because of the parallels to his own personal journey toward individuation. A chronological history of the development of Jung's dream theory is presented, followed by a picture of the relationship between Jung and Pauli. Thereafter, a detailed summary of the seminar transcripts, one given on Bailey Island, Maine, and the other in New York City the following year, is offered with hermeneutic commentary. An analysis of the seminars found that Pauli's dreams did, in part, support Jung's theory. Specifically, while Jung was unable to meet the scientific demands for clear empirical evidence of his dream theory, he did offer his professional and non-professional audiences with a slightly less rigorous example of his dream theory in action, demonstrating that the process shared similarities across peoples, time, and cultures. Additionally, in Pauli he found a superior mind that had gone through the process of individuation in accordance with his theory and his own experience. During the course of research, reference to a document was found in the correspondence in the Jungian Archives in Zurich. This document entitled, "FAREWELL SPEECH, Given by Dr. C. G. Jung on the Occasion of a Dinner Given in His Honor by the Analytical Psychology Club of New York City October 26, 1937" and other related documents were subsequently uncovered in the sub-basement of the Kristine Mann Library in New York City. A synopsis of the discovery and description of the papers contained in the file are discussed in

Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT

DEFF Research Database (Denmark)

Alssema, Marjan; Rijkelijkhuizen, Josina M; Holst, Jens Juul

2013-01-01

OBJECTIVE: To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN: A population......-based study. METHODS: A total of 163 persons with normal glucose metabolism (NGM), 20 with intermediate hyperglycaemia and 20 with type 2 diabetes aged 40-65 years participated. Participants received a mixed meal and oral glucose load on separate occasions. Glucagon-like peptide 1 (GLP-1), glucose......-dependent insulinotropic polypeptide (GIP) and glucagon profiles were analysed as total area under the curve (tAUC) and incremental area under the curve. RESULTS: In diabetic patients compared with persons with NGM, we found increased GLP-1 secretion (tAUC per hour) following oral glucose (23.2 pmol/l (95% CI 17...

Wolfgang Gentner Memorial

CERN Multimedia

CERN PhotoLab

1981-01-01

The Memorial was held in the Main Auditorium on 30 April 1981. The photo shows (centre, first row) Volker Soergel (DESY Director), Mrs. Gentner, Jean Teillac (President of the Council), Hélène Langevin-Joliot, Herwig Schopper (CERN Director-General).

Wolfgang Pauli Room

CERN Multimedia

Bennett, Sophia Elizabeth

2017-01-01

This small but historically valuable collection was donated by Pauli’s widow who, with the help of friends including his former assistants Charles Enz and Victor Weisskopf, gathered together Pauli’s manuscripts and notes, and tracked down originals or copies of his many letters. His correspondence with Bohr, Heisenberg Einstein and others, discussing many of the new ideas in physics, has been published (link) and provides an invaluable resource for those interested in studying the development of 20th century science. Unlike the main CERN Archive, most items in the Pauli collection have been digitised and are available online.

Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

Energy Technology Data Exchange (ETDEWEB)

Raţă, Delia Mihaela, E-mail: iureadeliamihaela@yahoo.com [„Apollonia” University of Iasi, Faculty of Medical Dentistry, „Academician Ioan Haulică” Research Institute (Romania); Chailan, Jean-François, E-mail: chailan@univ-tln.fr [University of Sud Toulon-Var, « Matériaux-Polymères-Interfaces-Environnement Marin (MAPIEM) Laboratory (France); Peptu, Cătălina Anişoara, E-mail: catipeptu@yahoo.co.uk [“Gheorghe Asachi” Technical University of Iasi, Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection (Romania); Costuleanu, Marcel, E-mail: mcostuleanu@yahoo.com [University of Medicine and Pharmacy “Grigore T. Popa”- Iaşi, Department of General Pathology, Faculty of Dental Medicine (Romania); Popa, Marcel, E-mail: marpopa2001@yahoo.fr [“Gheorghe Asachi” Technical University of Iasi, Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection (Romania)

2015-07-15

This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126–214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules.

Energy Level Tuning of Poly(phenylene-alt-dithienobenzothiadiazole)s for Low Photon Energy Loss Solar Cells.

Science.gov (United States)

Heuvel, Ruurd; van Franeker, Jacobus J; Janssen, René A J

2017-03-01

Six poly(phenylene- alt -dithienobenzothiadiazole)-based polymers have been synthesized for application in polymer-fullerene solar cells. Hydrogen, fluorine, or nitrile substitution on benzo-thiadiazole and alkoxy or ester substitution on the phenylene moiety are investigated to reduce the energy loss per converted photon. Power conversion efficiencies (PCEs) up to 6.6% have been obtained. The best performance is found for the polymer-fullerene combination with distinct phase separation and crystalline domains. This improves the maximum external quantum efficiency for charge formation and collection to 66%. The resulting higher photocurrent compensates for the relatively large energy loss per photon ( E loss = 0.97 eV) in achieving a high PCE. By contrast, the poly-mer that provides a reduced energy loss ( E loss = 0.49 eV) gives a lower photocurrent and a reduced PCE of 1.8% because the external quantum efficiency of 17% is limited by a suboptimal morphology and a reduced driving force for charge transfer.

Chitosan: poly( N-vinylpyrrolidone- alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

Science.gov (United States)

Raţă, Delia Mihaela; Chailan, Jean-François; Peptu, Cătălina Anişoara; Costuleanu, Marcel; Popa, Marcel

2015-07-01

This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly( N-vinylpyrrolidone- alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126-214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules.

Chitosan: poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules—a promising alternative for the lung cancer treatment

International Nuclear Information System (INIS)

Raţă, Delia Mihaela; Chailan, Jean-François; Peptu, Cătălina Anişoara; Costuleanu, Marcel; Popa, Marcel

2015-01-01

This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126–214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules

Solvent effect on post-irradiation grafting of styrene onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) films

Science.gov (United States)

Napoleão Geraldes, Adriana; Augusto Zen, Heloísa; Ribeiro, Geise; Fernandes Parra, Duclerc; Benévolo Lugão, Ademar

2013-03-01

Radiation-induced grafting of styrene onto ETFE films in different solvent was investigated after simultaneous irradiation (in post-irradiation condition) using a 60Co source. Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) are currently studied for synthesis of ion exchange membranes. The ETFE films were immersed in styrene/toluene, styrene/methanol and styrene/isopropyl alcohol and irradiated at 20 and 100 kGy doses at room temperature. The post-irradiation time was established at 14 day and the grafting degree was evaluated. The grafted films were sulfonated using chlorosulfonic acid and 1,2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The degree of grafting (DOG) was determined gravimetrically and physical or chemical changes were evaluated by differential scanning calorimeter analysis (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The ion exchange capacity (IEC) values showed the best performance of sulfonation for ETFE membranes grafted in toluene solvent. Surface images of the grafted films by SEM technique have presented a strong effect of the solvents on the films morphology.

Synthesis and photophysical and electroluminescent properties of poly(1,4-phenylene–ethynylene)-alt-poly(1,4-phenylene–vinylene)s with various dissymmetric substitution of alkoxy side chains

Czech Academy of Sciences Publication Activity Database

Bouguerra, N.; Růžička, Aleš; Ulbricht, C.; Enengl, C.; Enengl, S.; Pokorná, Veronika; Výprachtický, Drahomír; Tordin, E.; Aitout, R.; Cimrová, Věra; Egbe, D. A. M.

2016-01-01

Roč. 49, č. 2 (2016), s. 455-464 ISSN 0024-9297 R&D Projects: GA ČR(CZ) GA13-26542S; GA ČR(CZ) GAP106/12/0827 Institutional support: RVO:61389013 Keywords : poly(1,4-phenylene-ethynylene)-alt-poly(1,4-phenylene-vinylene)s * dissymmetric side chains * synthesis Subject RIV: CD - Macromolecular Chemistry Impact factor: 5.835, year: 2016

["I am rather satisfied with this interpretation of my dreams." -- real-life and work-related encounters between psychiatrist Johann Christian August Heinroth and poet Johann Wolfgang von Goethe].

Science.gov (United States)

Schmideler, S; Steinberg, H

2004-09-01

Apart from being a major pioneer of modern psychiatry, Johann Christian August Heinroth (1773 - 1843) is foremost famous as the first academic teacher, professor of this subject at Leipzig University. Despite his theoretical concepts being thoroughly investigated by medical historians, the fact that his scientific work also brought him in contact with Weimar poet and scientist Johann Wolfgang von Goethe (1749 - 1832) has up to now not been acknowledged. This paper analyses for the first time the manifold points of contact between the two geniuses. Starting off with a retrospective on Goethe's relationship towards psychiatry in his day, this paper investigates the mutual interconnections and influences between the two. This is achieved by an analysis of yet unknown primary sources as well as Goethe's literary and scientific works. A main emphasis is also placed on Heinroth's Textbook of Anthropology of 1822 in which the psychiatrist laid out his understanding of 'relational thinking' (gegenständliches Denken), a key concept for both. This theory developed from Heinroth's dealing with Goethe's concept of "anschauung" and was to gain major importance not only for his way of gaining knowledge in general but also for his psychiatric concept. Goethe's influence on Heinroth is particularly revealed in the latter's holistic views on mental illnesses. Heinroth's visit to Goethe on 15 September 1827 can be earmarked as a sign of their mutual esteem.

From Frankfurt to Cologne

DEFF Research Database (Denmark)

Celik, Tim Holst

2016-01-01

Review essay on: Wolfgang Streeck: Buying Time. The Delayed Crisis of Democratic Capitalism. (Verso, 2014)......Review essay on: Wolfgang Streeck: Buying Time. The Delayed Crisis of Democratic Capitalism. (Verso, 2014)...

Data on three-year pesticide monitoring in ditches of the apple orchard region of Altes Land, Germany

Directory of Open Access Journals (Sweden)

Stefan Lorenz

2018-06-01

Full Text Available The data presented in this article are related to the research article 'Chemical and biological monitoring of the load of plant protection products and of zoocoenoses in ditches of the orchard region Altes Land' (Süß et al., 2006 [1], which is only available in the German language. The pesticide data presented here were acquired from four ditches (three ditches were located in apple orchards, and one ditch was located in a grassland region between 2001 and 2003 (Lorenz et al., 2018 [2]. Two different monitoring strategies were applied: event-driven sampling after pesticide applications and weekly integrated sampling using automatic water samplers. A total of 70 active substances were monitored while farmers applied 25 active substances. This article describes the study sites and the analytical methods used to quantify the pesticides in the water samples. The field data set is publicly available at the OpenAgrar repository under https://doi.org/10.5073/20180213-144359 (Lorenz et al., 2018 [2].

A classification system for one Killing vector solutions of Einstein's equations

International Nuclear Information System (INIS)

Hoenselaers, C.

1978-01-01

A double classification system for one Killing vector solutions in terms of the eigenvectors and eigenvalues of the Ricci and Bach tensor of the associated three manifold is proposed. The calculations of the Bach tensor are carried out for special cases. (author)

Separator Membrane from Crosslinked Poly(Vinyl Alcohol and Poly(Methyl Vinyl Ether-alt-Maleic Anhydride

Directory of Open Access Journals (Sweden)

Charu Vashisth Rohatgi

2015-03-01

Full Text Available In this work, we report separator membranes from crosslinking of two polymers, such as poly vinyl alcohol (PVA with an ionic polymer poly(methyl vinyl ether-alt-maleic anhydride (PMVE-MA. Such interpolymer-networked systems were extensively used for biomedical and desalination applications but they were not examined for their potential use as membranes or separators for batteries. Therefore, the chemical interactions between these two polymers and the influence of such crosslinking on physicochemical properties of the membrane are systematically investigated through rheology and by critical gel point study. The hydrogen bonding and the chemical interaction between PMVE-MA and PVA resulted in highly cross-linked membranes. Effect of the molecular weight of PVA on the membrane properties was also examined. The developed membranes were extensively characterized by studying their physicochemical properties (water uptake, swelling ratio, and conductivity, thermal and electrochemical properties using differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, thermo-gravimetric analysis (TGA and electrochemical impedance spectroscopy (EIS. The DSC study shows the presence of a single Tg in the membranes indicating compatibility of the two polymers in flexible and transparent films. The membranes show good stability and ion conductivity suitable for separator applications.

Separator Membrane from Crosslinked Poly(Vinyl Alcohol) and Poly(Methyl Vinyl Ether-alt-Maleic Anhydride)

Science.gov (United States)

Rohatgi, Charu Vashisth; Dutta, Naba K.; Choudhury, Namita Roy

2015-01-01

In this work, we report separator membranes from crosslinking of two polymers, such as poly vinyl alcohol (PVA) with an ionic polymer poly(methyl vinyl ether-alt-maleic anhydride) (PMVE-MA). Such interpolymer-networked systems were extensively used for biomedical and desalination applications but they were not examined for their potential use as membranes or separators for batteries. Therefore, the chemical interactions between these two polymers and the influence of such crosslinking on physicochemical properties of the membrane are systematically investigated through rheology and by critical gel point study. The hydrogen bonding and the chemical interaction between PMVE-MA and PVA resulted in highly cross-linked membranes. Effect of the molecular weight of PVA on the membrane properties was also examined. The developed membranes were extensively characterized by studying their physicochemical properties (water uptake, swelling ratio, and conductivity), thermal and electrochemical properties using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA) and electrochemical impedance spectroscopy (EIS). The DSC study shows the presence of a single Tg in the membranes indicating compatibility of the two polymers in flexible and transparent films. The membranes show good stability and ion conductivity suitable for separator applications. PMID:28347019

Treatment of skeletal class III malocclusion using face mask therapy with alternate rapid maxillary expansion and constriction (Alt-RAMEC protocol

Directory of Open Access Journals (Sweden)

Anand Ramchandra Rathi

2015-01-01

Full Text Available Class III malocclusion is very common malocclusion and can be due to maxillary retrusion, mandibular prognathism, or combination. Ellis and McNamara found a combination of maxillary retrusion and mandibular protrusion to be the most common skeletal relationship (30%. The treatment should be carried out as early as possible for permitting normal growth of the skeletal bases. Reverse pull head gear combined with maxillary expansion can effectively correct skeletal Class III malocclusion due to maxillary deficiency in growing patient. An eight-year-old female patient with chief complaint of prognathic mandible and anterior crossbite was successfully treated in duration of 5 months with facemask and expansion therapy based on Alternate Rapid Maxillary Expansion and Constriction (Alt-RAMEC protocol.

Evaluation The Result Of Treating 1200 Patients Brain Tumor And Some Intracranial Diseases By Rotating GAMMA Knife (RGK) At The Nuclear Medicine And Oncology Center, Bach Mai Hospital

International Nuclear Information System (INIS)

Mai Trong Khoa; Nguyen Quang Hung; Tran Dinh Ha

2011-01-01

The paper is evaluating results of treating brain tumor and some intracranial diseases by rotating gamma knife (RGK) at The Nuclear Medicine and Oncology Center, Bach Mai Hospital, from July 2007 to August 2010, for 1200 patients treated with RGK. In 1200 patients - average age: 42.6 years old, Male/Female ratio:1/1.08 - pituitary tumors accounted for 19.8%, meningioma 18.3%, arteriovenous malformations (AVM) (16.7%), acoustic neuroma (8.7%), brain metastases (7.5%), craniopharyngeal tumor (5.0%), pineal tumor (3.5%), cavernoma (6%), astrocytoma (5.2%), meduloblastoma (2.9%), ependymoma (2.6%), others (3.8%). Average target volume: minimum 0.6cm 3 , maximum 27.6cm 3 , median 6.2 ± 4.6 cm 3 . Average radiosurgery dose changed depend on nature of the tumor: pituitary tumor (12.4 Gy), meningioma (18.8 Gy), AVM (18 Gy), acoustic neuroma (14.6 Gy), brain metastases (18.2 Gy), craniopharyngeal tumor (12.8 Gy), pineal tumor (16.3 Gy), cavernoma (17.5 Gy), astrocytoma (14.6 Gy), medulloblastoma (16.1 Gy), ependymoma (16.3 Gy), others (15 Gy). Conclusions: Almost case have improved clinical symptoms significantly: 80.2% after 1 month (complete response 20.2%), 100% at 36th month (complete response: 94%). Size of the tumor were reduced remarkably. Treatment were safe, no death or severe complications were observed within and after radiosurgery. (author)

A biography of Wolfgang Ernest Pauli; La vie de Wolfgang Ernest Pauli

Energy Technology Data Exchange (ETDEWEB)

Boudenot, J.C. [Thales, 91 - Palaiseau (France)

2009-01-15

This article presents a short biography of Pauli in which we find the most important facts of his scientific career and some stunning sides of his personality. Pauli was born in 1900 in Vienna in an intellectual family. He was very soon interested in physics. At the age of 21 he published a relevant article on relativity, and the same year he presented a doctorate thesis on the quantum description of the H{sub 2}{sup +} molecular ion. As soon as 1925, Pauli discovered the exclusion principle (for which he will receive the Nobel prize in 1945), and was the first to calculate the energy levels of the hydrogen atom by using the Heisenberg formalism. In 1930, he suggested the existence of an unknown particle (the neutrino) to explain the continuous spectrum of the beta decay. In 1934, he found a link between the spin and the quantum statistics that is now called the spin-statistic theorem. Pauli died in december 1958 from a pancreas tumor. (A.C.)

How We Can Win the Long War: A New Interagency Approach to the GWOT

Science.gov (United States)

2009-04-01

Johann Wolfgang Von Goethe states, “Boldness has genius, power, and magic in it. Begin it now.” 17...Case for Strengthening the Department of State” 1 16 Schwarzkopf, Norman, “Famous Military Quotes”, 1 17 Goethe , Johan Wolfgang Van, Famous

Morphological control of calcium oxalate particles in the presence of poly-(styrene-alt-maleic acid)

International Nuclear Information System (INIS)

Yu Jiaguo; Tang Hua; Cheng Bei; Zhao Xiujian

2004-01-01

Calcium oxalate (CaOx) particles exhibiting different shapes and phase structures were fabricated by a simple precipitation reaction of sodium oxalate with calcium chloride in the absence and presence of poly-(styrene-alt-maleic acid) (PSMA) as a crystal modifier at room temperature. The as-obtained products were characterized with scanning electron microscopy (SEM) and X-ray diffraction (XRD). The effects of reaction conditions including pH, [Ca 2+ ]/[C 2 O 4 2- ] ratio and concentration of PSMA and CaC 2 O 4 on the crystal forms and morphologies of the as-obtained calcium oxalate were investigated. The results show that various crystal morphologies of calcium oxalate, such as parallelograms, plates, spheres, bipyramids etc. can be obtained depending on the experimental conditions. Higher polymer concentration favors formation of the metastable calcium oxalate dihydrate (COD) crystals. Lower pH is beneficial to the formation of plate-like CaOx crystals. Especially, the monodispersed parallelogram-like CaOx crystals can be produced by PSMA as an additive at pH 2. PSMA may act as a good inhibitor for urolithiasis since it induces the formation of COD and reduces the particle size of CaOx. This research may provide new insight into the morphological control of CaOx particles and the prevention of urolithiasis

Ethnobotany of the Alt Empordà region (Catalonia, Iberian Peninsula): plants used in human traditional medicine.

Science.gov (United States)

Parada, Montse; Carrió, Esperança; Bonet, Maria Angels; Vallès, Joan

2009-07-30

This paper provides significant ethnobotanical information on pharmaceutical plant uses from a tourist and industrialised region, where some degree of acculturation exists, so that there is urgency in recording such data. To collect, analyze and evaluate the ethnobotanical knowledge about medicinal plants in a north-eastern Iberian region (Alt Empordà, 1358 km(2), 129,160 inhabitants). We performed 101 semi-structured interviews with 178 informants (mean age 69; 71% women, 29% men), identified the plant taxa reported and analyzed the results, comparing them with those from other territories. The informants reported data on 518 species. Of these, 335, belonging to 80 botanical families, were claimed as medicinal. This work is focused on human medicinal plant uses, which represent 98% of the pharmaceutical uses (3581 out of 3643 use reports). Around 800 medicinal uses, concerning 200 species, have not, or have very rarely been cited as medicinal; of these, 32 uses of 30 species have been reported by three or more independent informants. The folk knowledge about medicinal plant use is still alive in the studied region, and a number of scarcely reported plant uses has been detected, some of them with promising phytotherapeutical applications.

Evento com aparente risco de morte: uma revisão Evento con aparente riesgo de muerte (alte: una revisión Apparent life-threatening event: a review

Directory of Open Access Journals (Sweden)

Mariana Tresoldi das N. Romaneli

2012-12-01

Full Text Available OBJETIVO: Realizar uma revisão crítica reunindo informações disponíveis a respeito dos eventos com aparente risco de morte. FONTES DE DADOS: Revisão bibliográfica dos artigos (em português, inglês e espanhol obtidos dos bancos de dados eletrônicos Medline, Lilacs e SciELO, utilizando as palavras-chave: eventos com aparente risco de morte, evento com aparente risco de vida infantil, lactente, apneia, monitorização e cianose. SÍNTESE DOS DADOS: Os eventos com aparente risco de mortesão súbitos e caracterizados por uma combinação de apneia, alteração na coloração da pele e tônus muscular, com inúmeras causas subjacentes. Sua incidência verdadeira é desconhecida e a faixa etária mais acometida é de 11 a 12 semanas. Não há correlação entre o evento com aparente risco de morte e a síndrome da morte súbita do lactente, embora já tenham sido consideradas manifestações da mesma doença. Muitas vezes, o lactente tem aparência saudável ao ser avaliado pelo pediatra após apresentar eventos com aparente risco de morte, porém, isso não afasta a possibilidade de existir uma doença grave associada ao evento, que deve ser investigada e tratada. Quando não são encontradas as causas, o evento é idiopático, geralmente com boa evolução. CONCLUSÕES: É necessário investigar os lactentes levados ao pronto-socorro após apresentarem eventos com aparente risco de morte, devido ao risco de sequelas e mortalidade. Não há uma padronização das condutas a serem realizadas diante de um lactente com aparência saudável que tenha evento com aparente risco de morte, mas recomenda-se que o paciente seja internado e a causa do evento, investigada. A observação e o monitoramento em ambiente hospitalar devem ocorrer no mínimo 24 horas após o evento.OBJETIVO: Realizar una revisión crítica, reuniendo las informaciones disponibles respecto a los Eventos con Aparente Riesgo de Muerte (ALTE - Apparent life-threatening event

Fulltext PDF

Indian Academy of Sciences (India)

Infrastructure of the new neutrino experiment at a nuclear power station near the village of Chooz. IReproduced with permission from CERN Courier). Wolfgang Pauli. 11900 -1958 ). IllIustration by Prema Iyer). EditoriciJ r. ~ie! Editor'~ column. NMukundo . Wolfgang Pauli. NMukundo. Classroom. 79. Exchange and Sign-.

Els lepidòpters de la vall d’Alinyà (Alt Urgell, NE de la península Ibèrica: algunes consideracions sobre l’altitud i la classificació biogeogràfica

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Vallhonrat, F.

2005-12-01

Full Text Available The Lepidoptera of the Alinyà valley (Alt Urgell, NE Iberian peninsula: some remarks about altitude and biogeographical classification Results from the census on Lepidoptera fauna carried out in Alinyà valley during years 2000 and 2001 (see annex show few significant differences in the altitudinal range between Mediterranean and Eurasiatic species.

Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma.

Science.gov (United States)

Huang, Hao; Wang, Xue-Ping; Li, Xiao-Hui; Chen, Hao; Zheng, Xin; Lin, Jian-Hua; Kang, Ting; Zhang, Lin; Chen, Pei-Song

2017-08-14

The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease-related mortality. In our study, the relationship between pretreatment serum LFTs and overall survival (OS) was evaluated in esophageal squamous cell carcinoma (ESCC) patients. Our purpose was to investigate the prognostic value of the preoperative alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in ESCC patients. A retrospective study was performed in 447 patients with ESCC, and follow-up period was at least 60 months until death. The prognostic significance of serum LFTs were determined by univariate and multivariate Cox hazard models. LFTs including ALT, AST, LSR, GGT, TBA and LDH were analyzed. Serum LSR (HR: 0.592, 95% CI = 0.457-0.768, p < 0.001 and GGT (HR: 1.507, 95% CI = 1.163-1.953, p = 0.002) levels were indicated as significant predictors of OS. The 5-year OS among patients with higher LSR levels was longer compared with those patients with decreased LSR levels, not only in the whole cohort but also in the subgroups stratified by pathological stage (T1-T2 subgroup, T3-T4 subgroup, N0 subgroup and M0 subgroup). We also found that patients with a higher GGT might predict worse OS than patients with a normal GGT, not only in the whole cohort but also in the subgroups stratified by pathological stage (T3-T4 subgroup and N1-N2 subgroup). Both increased levels of LSR and decreased levels of GGT might predict shorter overall survival in ESCC patients. Our findings suggest that serum LSR and GGT levels could be used as a key predictor of survival in patients with ESCC.

High-resolution δ13C record of fossil wood and bulk organic matter from a deep Oligocene lacustrine succession, Bach Long Vi Island, Vietnam

Science.gov (United States)

Rizzi, M.; Schovsbo, N. H.; Fyhn, M. B. W.; Korte, C.

2017-12-01

We present a high-resolution stable isotope record based on bulk organic matter (δ13Corg) and fossil wood (δ13Cwood) originating from Oligocene deep lacustrine sediments cored on the Bach Long Vi Island, northern Gulf of Tonkin, offshore Vietnam. The sediments are exceptionally well preserved. They are thus excellently suited for a detailed stratigraphical analysis of the stable isotope record and as proxy for environmental and climatic changes within this period. The sediments were deposited in rapid subsiding, narrow and elongated fault-bound graben (Fyhn and Phach, 2015) and are represented by deep pelagic lacustrine organic-rich mud interrupted by numerous density-flow deposits (Hovikoski et al., 2016). The density-flow deposits contain abundant fragments of fossil wood. Therefore it was possible to obtain 262 coalified wood fragments together with 1063 bulk organic samples throughout the span of the core. This allowed to establish a high resolution stable C isotope record (δ13Corg and δ13Cwood). In addition 2464 handheld XRF determinations were carried out to further characterize the depositional environment (Rizzi et al., 2017). The organic carbon isotope trend from the 500 m core succession provides insight into the palaeoenvironmental changes of the lake during the Oligocene. Both, global and local factors control the δ13C variations. The aim of the study is to obtain pure global δ13Corg and δ13Cwood signals that would allow comparison of the studied sediments with coeval syn-rift successions in the South China Sea region and other parts of the world. [1] Fyhn and Phach (2015) Tectonics, 34(2): 290-312. [2] Hovikoski et al. (2016) Journal of Sedimentary Research, 86(8): 982-1007. [3] Rizzi et al. (2017) EGU General Assembly Abstract EGU 2017-17584.

Scaling laws for soliton pulse compression by cascaded quadratic nonlinearities (vol 24, pg 2752, 2007)

DEFF Research Database (Denmark)

Bache, Morten; Moses, J.; Wise, F.W.

2010-01-01

Erratum for [M. Bache, J. Moses, and F. W. Wise, "Scaling laws for soliton pulse compression by cascaded quadratic nonlinearities," J. Opt. Soc. Am. B 24, 2752-2762 (2007)].......Erratum for [M. Bache, J. Moses, and F. W. Wise, "Scaling laws for soliton pulse compression by cascaded quadratic nonlinearities," J. Opt. Soc. Am. B 24, 2752-2762 (2007)]....

High resolution HH-XRF scanning and XRD modelling as a tool in sedimentological analysis - A case study from the Enreca-3 core, Bach Long Vi Island, Vietnam

Science.gov (United States)

Rizzi, Malgorzata; Hemmingsen Schovsbo, Niels; Korte, Christoph; Bryld Wessel Fyhn, Michael

2017-04-01

To improve the understanding and interpretation of the depositional environment of a late Oligocene lacustrine organic rich oil-prone source rock succession, 2464 hand held (HH)-XRF measurements were made systematically on the 500 m long, continuous core from the fully cored Enreca-3 well. This core, drilled on the remote Bach Long Vi Island, northern Gulf of Tonkin, offshore Vietnam, represents a deep lake succession alternating between lacustrine pelagic dominated sediments interrupted by hyperpycnal turbidites, high density turbidites and debris flows [1, 2]. From a combined HH-XRF-XRD data set, multivariate data analysis and regression models are used to type the rock and to predict the XRD mineral composition based on HH-XRF composition. The rock types and the modelled mineral composition highlight the geochemical variations of the sediment and allows for direct comparison with sedimentological processes and facies changes. The modeling also depicts the cyclic alteration of rock types that are present on many different scales ranging from centimeters to hundreds of meters [1, 2]. The sedimentological and geochemical variations observed throughout the cored section reflects fluctuating paleoclimate, tectonism and hinterland condition controlling the depositional setting, which may provide a deeper understanding of the deposition of this and similar Paleogene syn-rift succession in the South China Sea region. It allows furthermore the development of a more generalized depositional model relevant for other deep-lacustrine syn-rift basins. [1] Petersen et al. (2014) Journal of Petroleum Geology, 37: 373-389. [2] Hovikoski et al. (2016) Journal of Sedimentary Research, 86(8): 982-1007.

Resonance – Journal of Science Education | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Wolfgang Polasek. Articles written in Resonance – Journal of Science Education. Volume 5 Issue 8 August 2000 pp 26-42 General Article. The Bernoullis and the Origin of Probability Theory: Looking back after 300 Years · Wolfgang Polasek · More Details ...

Chemostratigraphy and trace element pattern of authigenic pyrite in a Frasnian-Fammenian transition section (Büdesheimer bach, Germany)

Science.gov (United States)

Pujol, F.; Berner, Z.; Neumann, T.; Stüben, D.

2003-04-01

Trace element contents in authigenic pyrite were investigated in relationship to the geochemistry of host rocks in a 160 m deep drilling at Büdesheimer Bach (Prümer Mulde, Germany), in order to put constrains on possible changes in depositional conditions and seawater composition related to the Kellwasser events (Frasnian/Fammenian transition). The approach is based on the observation that the trace element pattern of authigenic pyrite is controlled by genetic conditions (Stüben et al., 2002) and that the content of elements with generally high degree of pyritization (DTMP, degree of trace metal pyritization, like As, Mo, Co, Ni, etc.) depends on their availability at the site of pyrite formation (e.g. Huerta-Diaz and Morse, 1992). The distribution of trace elements in the bulk rock essentially reflects mineralogical composition and redox conditions which are mainly controlled by the flux of organic matter entering the sediment. The lower and upper Kellwasser horizons are marked by an increase in carbonate and organic carbon content (up to 2%), coupled with an increase in the degree of pyritization of Fe (DOP: 0.4-0.8), indicating a change from normal marine to suboxic/anoxic conditions. A simultaneous drop in the Ba content of the host lithology, which usually is used as a proxy for paleoproductivity, can be explained by the removal of Ba dissolved in pore water under anoxic conditions (McManus et al., 1998). While low in the host rock, the Ba content of authigenic pyrite is high in these horizons, suggesting that pyrite may preserve the initial composition of pore water even for some elements with generally low DTMP, like Ba. Consequently, Ba content in pyrite may serve as indicator for productivity even when the Ba content of sediment can not be used due to its poor preservation. During these anoxic episodes also a significant increase in the content of As, U, V was registered in pyrite. Opposite to these, others like Ni, Co, Ag show a decrease in their

Soil and Water Assessment Tool soil loss simulation at the sub-basin scale in the Alt Penedès-Anoia vineyard region (Ne Spain) in the 2000s

OpenAIRE

Martínez Casasnovas, José Antonio; Ramos Martín, Ma. C. (Ma. Concepción); Benites, Grace

2016-01-01

This paper evaluates soil loss due to water erosion in an area of 32,362 ha with a predominant land use of vineyards (Alt Penedès-Anoia region, Catalonia, Spain). The Soil and Water Assessment Tool (SWAT) was used incorporating daily climatic data for the period 2000-2010 and also detailed soil and land use maps. Particular attention was given to the universal soil loss equation cover and management factor (C factor) of vineyards, with a minimum value of 0·15 being determined for this crop. T...

A New Paradigm for the Information Age

DEFF Research Database (Denmark)

Brier, Søren; Liqian, Zhou

2014-01-01

Review of Wolfgang Hofkirchner's Emergent Information: A Unified Theory of Information Framework. Published in 2013 by World Scientific in Singapore. 280 pages. ISBN 978-981-4313-48-3......Review of Wolfgang Hofkirchner's Emergent Information: A Unified Theory of Information Framework. Published in 2013 by World Scientific in Singapore. 280 pages. ISBN 978-981-4313-48-3...

La incidencia de la helada de 1956 en el Olivar de Navata (Alt Empordà, Girona

Directory of Open Access Journals (Sweden)

Sandra Ricart Casadevall

2009-01-01

Full Text Available En la comarca del Alt Empordà (Girona, el olivar ha configurado históricamente un paisaje de alto valor económico, cultural y ambiental si bien desde mediados del siglo XX se encuentra en fuerte regresión. Uno de los municipios situados en el límite de la plana altoampurdanesa que mejor ejemplifican este proceso de abandono y casi desaparición del olivar es Navata. Este artículo analiza los cambios experimentados en el olivar de este municipio en el periodo 1957-2004 a través tanto de la elaboración de una cartografía de usos y cubiertas del suelo a escala de detalle como del análisis de fuentes estadísticas y orales, ejercicio que pone de relieve la pérdida del 90% del olivar existente a mediados del siglo pasado. La helada de febrero de 1956 fue uno de los principales causantes, pero no el único. Sin embargo, tanto la importancia del olivar como elemento identitario y de conservación de la biodiversidad como el carácter diferenciador del aceite que se obtiene a partir de variedades propias de la zona (especialmente la argudell, justifican la necesidad de impulsar políticas que ayuden a su recuperación.

[Value of non-invasive models of liver fibrosis in judgment of treatment timing in chronic hepatitis B patients with ALT < 2×upper limit of normal].

Science.gov (United States)

Zhou, Q Q; Hu, Y B; Zhou, K; Zhang, W W; Li, M H; Dong, P; Di, J G; Hong, L; Du, Q W; Xie, Y; Sun, Q F

2016-09-20

Objective: To investigate the value of non-invasive liver fibrosis models, FIB-4, S index, aspartate aminotransferase to platelet ratio index(APRI), globulin-platelet(GP)model, aspartate aminotransferase/platelet/gamma-glutamyl transpeptidase/alpha-fetoprotein(APGA), and platelet/age/phosphatase/alpha-fetoprotein/aspartate aminotransferase(PAPAS), in the diagnosis of marked liver fibrosis in chronic hepatitis B(CHB)patients with ALT liver biopsy was performed to obtain pathological results, and routine serological tests were performed, including routine blood test, serum biochemical parameters, hepatitis B virus(HBV)markers, and HBV DNA. According to liver pathology, the patients were divided into non-marked liver fibrosis group(S liver fibrosis group(S≥2)with 65 patients. The non-invasive models for predicting liver fibrosis was established with reference to original articles. SPSS 19.0 software was used for statistical analysis, and the receiver operating characteristic(ROC)curve was used to compare the value of different non-invasive models in predicting marked liver fibrosis in this population. Results: All the non-invasive models had a certain diagnostic value for liver fibrosis degree in these patients, and the areas under the ROC curve for APRI, FIB-4, APGA, S index, PAPAS, and GP model were 0.718, 0.691, 0.758, 0.729, 0.673, and 0.691, respectively. APGA had the largest area under the ROC curve(0.758, 95% CI 0.673-0.844), and gamma-glutamyl transpeptidase was significantly positively correlated with liver fibrosis degree. Conclusion: The non-invasive models of liver fibrosis can identify marked liver fibrosis in CHB patients with ALT liver biopsy to the certain degree.

The Magnaporthe oryzae Alt A 1-like protein MoHrip1 binds to the plant plasma membrane.

Science.gov (United States)

Zhang, Yi; Liang, Yingbo; Dong, Yijie; Gao, Yuhan; Yang, Xiufen; Yuan, Jingjing; Qiu, Dewen

2017-10-07

MoHrip1, a protein isolated from Magnaporthe oryzae, belongs to the Alt A 1 (AA1) family. mohrip1 mRNA levels showed inducible expression throughout the infection process in rice. To determine the location of MoHrip1 in M. oryzae, a mohrip1-gfp mutant was generated. Fluorescence microscopy observations and western blotting analysis showed that MoHrip1 was both present in the secretome and abundant in the fungal cell wall. To obtain MoHrip1 protein, we carried out high-yield expression of MoHrip1 in Pichia pastoris. Treatment of tobacco plants with MoHrip1 induced the formation of necrosis, accumulation of reactive oxygen species and expression of several defense-related genes, as well as conferred disease resistance. By fusion to green fluorescent protein, we showed that MoHrip1 was able to bind to the tobacco and rice plant plasma membrane, causing rapid morphological changes at the cellular level, such as cell shrinkage and chloroplast disorganization. These findings indicate that MoHrip1 is a microbe-associated molecular pattern that is perceived by the plant immune system. This is the first study on an AA1 family protein that can bind to the plant plasma membrane. Copyright © 2017 Elsevier Inc. All rights reserved.

Body and Surface Wave Modeling of Observed Seismic Events

Science.gov (United States)

1981-04-30

mechanisms for foreshock , mainshock, and aftershock sequences using Seismic Research Observatory (SRO) data, EOS, 57(12), p. 954, 1976. Bache, T.C., W.L...the event as well as that of the immediate foreshock were 95 located (Allen and Nordquist, 1972) and where the largest surface displacements were...1972). Foreshock , main shock and larger aftershocks of the Borrego Mountain earthquake, U. S. Geological Survey Professional Paper 787, 16-23. Bache

Local supertwistors

International Nuclear Information System (INIS)

Merkulov, S.A.

1987-01-01

Geometry of local supertwistors is investigated. It is proved that the Yang-Mills equations for the introduced ansatz for supertwistor connection are equivalent to free bach equations, describing the dynamics of N=1 conformal supergravity. Analogous interpretation of the dynamics of N=1 conformal supergravity coupled to a vector superfield is proposed. It is proved that any complex conformally right or left flat superspace automatically satisfies the Bach equations

Altındere Vadisi Milli Parkı kullanıcılarının rekreasyonel memnuniyetinin belirlenmesi

Directory of Open Access Journals (Sweden)

Özge Volkan AKSU

2017-07-01

Full Text Available Bu çalışma; Altındere Vadisi Milli Parkı kullanıcılarının rekreasyonel memnuniyetinin belirlenmesi amacı ile 2015 yılı yaz dönemi milli park alanında, 308 yerli kullanıcı ile yapılan anket çalışmalarını kapsamaktadır. Anket soruları ile kullanıcılarının bazı kişisel özellikleri, kullanım tercihleri, katıldıkları rekreasyonel etkinlikler, geliş amaçları, alan tercihleri, genel ve beklenen memnuniyetleri, alan farkındalığı, kullanıcı memnuniyet ve memnuniyetsizlik durumunu etkileyen faktörler ve bu faktörlerle kullanıcıların bazı kişisel özellikleri arasındaki ilişkiler istatistiksel yöntemlerle irdelenmiştir. Sonuç olarak; “milli parkın doğal ve kültürel peyzaj değerleri, görsel kalite”, “alandan aktif olarak yararlanma isteği”, “alandan pasif olarak yararlanma isteği”, “macera ve kendini keşfetme”, “açık hava aktivite olanakları”, “sosyalleşme”,  “ulaşılabilirlik ve alan kullanımı” olarak tanımlanabilecek faktörlerin alandaki kullanıcı memnuniyeti üzerinde etkili olduğu, yine; “planlama-tasarım sorunları”, “donatı elemanı eksikliği, yönetim”, “taşıma kapasitesinin aşılması-kalabalık, gürültü kirliliği”, “çevre-görüntü kirliliği, alt yapı-bakım eksikliği”, “bilgi eksikliği ve yönetim” olarak tanımlanabilecek faktörlerin ise kullanıcı memnuniyetsizliği üzerinde etkili olduğu belirlenmiştir. Kullanıcıların genel memnuniyet ve beklentilerinin karşılanma durumu orta düzeydir. Kullanıcıların memnuniyet faktörlerinin, geldiği yerin milli parka uzaklığı ve eğitim, memnuniyetsizlik faktörlerinin ise geldiği yerin milli parka uzaklığı, cinsiyet ve yaş olarak belirlenen etmenlerden etkilendiği saptanmıştır.

Til vægs

DEFF Research Database (Denmark)

Egemose, Ellen

abstraktion og mellem rumlighed og flade, og som i varierende grad strider mod at underordne sig motivernes figurer og handling. Med afsæt fra Wolfgang Iser og Wolfgang Kemps receptionsæstetik – og i et indledende forsøg på at kaste et kritisk blik på projektets geografiske empiriafgrænsning – spørger jeg: Er...

Metamorphosing art: multimedia spectacles as new forms of art and education

OpenAIRE

Santana, Helena; Santana, Rosário

2004-01-01

The interaction of different domains of knowledge and art, namely music, theatre, design, mathematics, physics… contributes to organise a musical performance that has an original form and develops new forms of education. Using different art forms – BACH2CAGE - is an original spectacle who confluences different domains of knowledge, communication and art. “More than a performance, Bach2Cage is a process, an experimental laboratory in crossing music/performing arts with multimedia/digital ...

The LTDP ALTS Project: Contributing to the Continued Understanding and Exploitation of the ATSR Time Series

Science.gov (United States)

Clarke, Hannah; Done, Fay; Casadio, Stefano; Mackin, Stephen; Dinelli, Bianca Maria; Castelli, Elisa

2016-08-01

The long time-series of observations made by the Along Track Scanning Radiometers (ATSR) missions represents a valuable resource for a wide range of research and EO applications.With the advent of ESA's Long-TermData Preservation (LTDP) programme, thought has turned to the preservation and improved understanding of such long time-series, to support their continued exploitation in both existing and new areas of research, bringing the possibility of improving the existing data set and to inform and contribute towards future missions. For this reason, the 'Long Term Stability of the ATSR Instrument Series: SWIR Calibration, Cloud Masking and SAA' project, commonly known as the ATSR Long Term Stability (or ALTS) project, is designed to explore the key characteristics of the data set and new and innovative ways of enhancing and exploiting it.Work has focussed on: A new approach to the assessment of Short Wave Infra-Red (SWIR) channel calibration.; Developmentof a new method for Total Column Water Vapour (TCWV) retrieval.; Study of the South Atlantic Anomaly (SAA).; Radiative Transfer (RT) modelling for ATSR.; Providing AATSR observations with their location in the original instrument grid.; Strategies for the retrieval and archiving of historical ATSR documentation.; Study of TCWV retrieval over land; Development of new methods for cloud masking This paper provides an overview of these activities and illustrates the importance of preserving and understanding 'old' data for continued use in the future.

Rhodium-Coordinated Poly(arylene-ethynylene)-alt-Poly(arylene-vinylene) Copolymer Acting as Photocatalyst for Visible-Light-Powered NAD+/NADH Reduction

Science.gov (United States)

2014-01-01

A 2,2′-bipyridyl-containing poly(arylene-ethynylene)-alt-poly(arylene-vinylene) polymer, acting as a light-harvesting ligand system, was synthesized and coupled to an organometallic rhodium complex designed for photocatalytic NAD+/NADH reduction. The material, which absorbs over a wide spectral range, was characterized by using various analytical techniques, confirming its chemical structure and properties. The dielectric function of the material was determined from spectroscopic ellipsometry measurements. Photocatalytic reduction of nucleotide redox cofactors under visible light irradiation (390–650 nm) was performed and is discussed in detail. The new metal-containing polymer can be used to cover large surface areas (e.g. glass beads) and, due to this immobilization step, can be easily separated from the reaction solution after photolysis. Because of its high stability, the polymer-based catalyst system can be repeatedly used under different reaction conditions for (photo)chemical reduction of NAD+. With this concept, enzymatic, photo-biocatalytic systems for solar energy conversion can be facilitated, and the precious metal catalyst can be recycled. PMID:25130570

Análise de diferentes modelos para a correção geométrica de imagens orbitais de altíssima resolução

OpenAIRE

Marotta, Giuliano Sant'anna

2008-01-01

Imagens provenientes de sensores orbitais de altíssima resolução vêm sendo cada vez mais utilizadas em diversos trabalhos, tais como: confecção de base de dados para uso em Sistema de Informações Geográficas (SIG); atualização e ou confecção de mapas em escalas regionais; auxílio no planejamento e organização do espaço em âmbito regional, municipal e ou urbano; etc. A alta resolução espacial desses sensores permite a identificação de muitas feições com boa definição, e proporcionam maior faci...

Radiation induced, raft mediated grafting of styrene onto poly(ethylene-alt-tetrafluoroethylene) (ETFE)

International Nuclear Information System (INIS)

Celik, G.; Barsbay, M.; Gueven, O.

2011-01-01

Complete text of publication follows. The development of cost-effective proton exchange membranes to replace the state-of-the-art and expensive perfluorinated membranes such as Nafion, Flemion, and Aciplex is one of the main challenges for commercialization of polymer electrolyte fuel cell technology. Recently, partially fluorinated poly(ethlyene-alt-tetrafluoroethylene) (ETFE) has been identified as a promising alternative base polymer film to prepare low-cost polymer electrolyte membranes because of its advantageous characters like superior mechanical properties and high resistance to radiation-induced damage. The radiation-induced grafting technique, based on the utilization of a polymer material such as ETFE in combination with further chemical modification steps (sulfonation) allows the functionalization of the base material and the introduction of the desired property (proton conductivity) for preparing a fuel cell membrane. However this simple conventional method suffers from one simple flaw: The molecular weight and the polydispersity of the grafted chains cannot be controlled. Predetermined molecular weights and low dispersities as well as homogeneous composition and desired architecture can be achieved by grafting of monomer onto base polymer under living/controlled free radical polymerization (CRP) conditions. Among the CRP methods, Reversible Addition Fragmentation-Chain Transfer (RAFT) is of particular interest as a very wide range of functional monomers can be polymerized in a controlled manner under non-demanding reaction conditions (e.g., tolerance to oxygen and low temperatures). The present study deals with the RAFT mediated radiation-induced (0.032 kGyh -1 , 60 Co) grafting of styrene on ETFE films followed by the sulfonation of the polystyrene grafts. The effect of monomer concentration, absorbed dose and RAFT agent concentration on the grafting were investigated. The synthesized films were characterized by ATR-FTIR, XPS, DSC and TGA methods

Alt und Alt gleich Neu / Peter J. Strehmel

Index Scriptorium Estoniae

Strehmel, Peter J.

1994-01-01

Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: 1200-1600, Medieval Renaissance (CD I "Instrumental Music", CD II "Vocal Music"). Erdenklang 40692-1+2; Hortus Musicus - Andres Mustonen: Himmel / Earth / Heaven / Erde: Gregorianische Chorale, Plainchants. Erdenklang 40712

Efeitos da farinha de folhas de mandioca sobre a atividade das enzimas AST, ALT, FA e lipídios hepáticos de ratos Wistar Effects of cassava leaves flour on the AST, ALT, ALP enzymes activity and hepatic lipids of Wistar rats

Directory of Open Access Journals (Sweden)

Daniela Séfora de Melo

2008-12-01

Full Text Available Folhas de mandioca possuem substâncias como ligninas e saponinas que podem apresentar efeito hipolipidêmico. Todavia, um estudo recente relatou aumento no peso do fígado de ratos alimentados com dietas contendo farinha de folhas de mandioca (FFM - Manihot esculenta Crantz cv. Cacao, tornando-se necessário um estudo mais aprofundado dos efeitos desta farinha sobre os parâmetros hepáticos. Para este estudo, um ensaio biológico com 32 ratos machos Wistar foi conduzido por um período de 7 semanas, sendo os tratamentos: dieta controle e dietas contendo 5, 10 e 15% de FFM. As dietas contendo FFM não apresentaram efeitos sobre as atividades das enzimas Aspartato Aminotransferase (AST e Fosfatase Alcalina (FA, mas aumentaram significativamente a atividade da enzima alanina aminotransferase (ALT. O estudo histopatológico revelou vacuolização do citoplasma dos hepatócitos para todos os grupos. No entanto, a freqüência de animais com vacuolização acentuada foi superior nos grupos que receberam dietas com FFM, apresentando também maiores teores de lipídios e colesterol total hepáticos e maior relação peso fígado/peso corporal. Estes resultados indicam que os antinutrientes presentes nas folhas de mandioca, como taninos, cianeto e saponinas, podem ser responsáveis pela redução da função hepática nos animais alimentados com FFM.Cassava leaves contain substances such as lignins and saponins that can present the hypolipidemic effect. However, a recent study has reported an increase in liver weight of rats fed diet containing cassava leaves flour (CLF - Manihot esculenta Crantz cv. Cacao. Thus, a further study of the effect of this flour on the hepatic parameters is necessary. For the development of this study, a biological assay with 32 male Wistar rats was conducted for a period of 7 weeks with the following treatments: control diet and diets containing 5, 10, and 15% of CLF. The diets containing CLF showed no effects on the

7th International Conference on Elementary and Analytic Number Theory

CERN Document Server

Steuding, Jörn; Steuding, Rasa

2016-01-01

This book collects more than thirty contributions in memory of Wolfgang Schwarz, most of which were presented at the seventh International Conference on Elementary and Analytic Number Theory (ELAZ), held July 2014 in Hildesheim, Germany. Ranging from the theory of arithmetical functions to diophantine problems, to analytic aspects of zeta-functions, the various research and survey articles cover the broad interests of the well-known number theorist and cherished colleague Wolfgang Schwarz (1934-2013), who contributed over one hundred articles on number theory, its history and related fields. Readers interested in elementary or analytic number theory and related fields will certainly find many fascinating topical results among the contributions from both respected mathematicians and up-and-coming young researchers. In addition, some biographical articles highlight the life and mathematical works of Wolfgang Schwarz.

Fiddling around with physics

Science.gov (United States)

Yunger Halpern, Nicole

2012-09-01

The thought experiment evolved during the holidays, which freed my mind to cartwheel through the temple of logic. Exams had ended weeks before; Dartmouth College had forked over a diploma and booted me off campus; and I needed a breather before studying for postgraduate admissions tests. As the Stokes relation wriggled into my long-term memory, Bach boomed in my earbuds - and I began to imagine George Stokes playing Bach, in a band composed of history's great physicists.

Plastic Fishes

CERN Multimedia

Trettnak, Wolfgang

2015-01-01

In terms of weight, the plastic pollution in the world’s oceans is estimated to be around 300,000 tonnes. This plastic comes from both land-based and ocean-based sources. A lecture at CERN by chemist Wolfgang Trettnak addressed this issue and highlighted the role of art in raising people’s awareness. The slideshow below gives you a taste of the artworks by Wolfgang Trettnak and Margarita Cimadevila.

The Chevreton tensor and Einstein-Maxwell spacetimes conformal to Einstein spaces

International Nuclear Information System (INIS)

Bergqvist, Goeran; Eriksson, Ingemar

2007-01-01

In this paper, we characterize the source-free Einstein-Maxwell spacetimes which have a trace-free Chevreton tensor. We show that this is equivalent to the Chevreton tensor being of pure radiation type and that it restricts the spacetimes to Petrov type N or O. We prove that the trace of the Chevreton tensor is related to the Bach tensor and use this to find all Einstein-Maxwell spacetimes with a zero cosmological constant that have a vanishing Bach tensor. Among these spacetimes we then look for those which are conformal to Einstein spaces. We find that the electromagnetic field and the Weyl tensor must be aligned, and in the case that the electromagnetic field is null, the spacetime must be conformally Ricci-flat and all such solutions are known. In the non-null case, since the general solution is not known on a closed form, we settle by giving the integrability conditions in the general case, but we do give new explicit examples of Einstein-Maxwell spacetimes that are conformal to Einstein spaces, and we also find examples where the vanishing of the Bach tensor does not imply that the spacetime is conformal to a C-space. The non-aligned Einstein-Maxwell spacetimes with vanishing Bach tensor are conformally C-spaces, but none of them are conformal to Einstein spaces

Music, Mathematics and Bach

Indian Academy of Sciences (India)

Western music allows the idea of 'modulation' from one key to another. ... 'tonic' in Indian music the tonic 'sa' is played throughout by the tanpura, and ... rules and greater freedom. A fugue ..... theorem and artificial intelligence but an excellent.

Inter- and intra-annual variability of fluvial sediment transport in the proglacial river Riffler Bach (Weißseeferner, Ötztal Alps, Tyrol)

Science.gov (United States)

Baewert, Henning; Weber, Martin; Morche, David

2015-04-01

The hydrology of a proglacial river is strongly affected by glacier melting. Due to glacier retreat the effects of snow melt and rain storms will become more important in future decades. Additionally, the development of periglacial landscapes will play a more important role in the hydrology of proglacial rivers. The importance of paraglacial sediment sources in sediment budgets of glacier forefields is increasing, while the role of glacial erosion is declining. In two consecutive ablation seasons the fluvial sediment transport of the river Riffler Bach in the Kaunertal (Tyrol/Austria) was quantified. The catchment area of this station is 20 km² with an altitudinal range from 1929 m to 3518 m above msl. The "Weißseeferner" glacier (2.34 km² in 2012) is the greatest of the remaining glaciers. An automatic water sampler (AWS 2002) and a probe for water level were installed were installed at the outlet of the catchment. In order to calculate annual stage-discharge-relations, discharge (Q) was repeatedly measured with current meters. Concurrent to the discharge measurements bed load was collected using a portable Helley-Smith sampler. Bed load (BL) samples were weighted and sieved in the laboratory to gain annual bed load rating curves and grain size distributions. In 2012, 154 water samples were sampled during 7 periods and subsequently filtered to quantify suspended sediment concentrations (SSC). A Q-SSC-relation was calculated for every period due to the high variability in suspended sediment transport. In addition, the grain size distribution of the filtered material was determined by laser diffraction analysis. In 2013, the same procedure was performed for 232 water samples which were collected during 9 periods. Meteorological data were logged at the climate station "Weißsee", which is located in the centre of the study area. First results show a high variability of discharge and solid sediment transport both at the inter-annual as well as at the intra

Behavior-aware cache hierarchy optimization for low-power multi-core embedded systems

Science.gov (United States)

Zhao, Huatao; Luo, Xiao; Zhu, Chen; Watanabe, Takahiro; Zhu, Tianbo

2017-07-01

In modern embedded systems, the increasing number of cores requires efficient cache hierarchies to ensure data throughput, but such cache hierarchies are restricted by their tumid size and interference accesses which leads to both performance degradation and wasted energy. In this paper, we firstly propose a behavior-aware cache hierarchy (BACH) which can optimally allocate the multi-level cache resources to many cores and highly improved the efficiency of cache hierarchy, resulting in low energy consumption. The BACH takes full advantage of the explored application behaviors and runtime cache resource demands as the cache allocation bases, so that we can optimally configure the cache hierarchy to meet the runtime demand. The BACH was implemented on the GEM5 simulator. The experimental results show that energy consumption of a three-level cache hierarchy can be saved from 5.29% up to 27.94% compared with other key approaches while the performance of the multi-core system even has a slight improvement counting in hardware overhead.

Post-irradiation time effects on the graft of poly(ethylene-alt-tetrafluoroethylene) (ETFE) films for ion exchange membrane application

Energy Technology Data Exchange (ETDEWEB)

Geraldes, Adriana N., E-mail: angeral@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Centro de Quimica e Meio Ambiente (CQMA), Av. Professor Lineu Prestes, 2242, 05508-900, Sao Paulo (Brazil); Zen, Heloisa A.; Ribeiro, Geise; Ferreira, Henrique P.; Souza, Camila P.; Parra, Duclerc F.; Santiago, Elisabete I.; Lugao, Ademar B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Centro de Quimica e Meio Ambiente (CQMA), Av. Professor Lineu Prestes, 2242, 05508-900, Sao Paulo (Brazil)

2010-03-15

Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) was studied for synthesis of ion exchange membranes. Radiation-induced grafting of styrene onto ETFE films was investigated after simultaneous irradiation (in post-irradiation condition) using a {sup 60}Co source. The ETFE films were irradiated at 20 kGy dose at room temperature and chemical changes were monitored after contact with styrene for grafting. The post-irradiation time was established at 14 days when the films were remained in styrene/toluene 1:1 v/v. After this period the grafting degree was evaluated in the samples. The grafted films were sulfonated using chlorosulfonic acid and 1, 2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The membranes were analyzed by infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermogravimetric measurements (TG) and degree of grafting (DOG). The ion exchange capacity (IEC) of membranes was determined by acid-base titration and the values for ETFE membranes were achieved higher than Nafion films. Preliminary single cell performance was made using pure H{sub 2} and O{sub 2} as reactants at a cell temperature of 80 deg. C and atmospheric gas pressure. The fuel cell performance of ETFE films was satisfactory when compared to state-of-art Nafion membranes.

Post-irradiation time effects on the graft of poly(ethylene-alt-tetrafluoroethylene) (ETFE) films for ion exchange membrane application

Science.gov (United States)

Geraldes, Adriana N.; Zen, Heloísa A.; Ribeiro, Geise; Ferreira, Henrique P.; Souza, Camila P.; Parra, Duclerc F.; Santiago, Elisabete I.; Lugão, Ademar B.

2010-03-01

Grafting of styrene followed by sulfonation onto poly(ethylene-alt-tetrafluoroethylene) (ETFE) was studied for synthesis of ion exchange membranes. Radiation-induced grafting of styrene onto ETFE films was investigated after simultaneous irradiation (in post-irradiation condition) using a 60Co source. The ETFE films were irradiated at 20 kGy dose at room temperature and chemical changes were monitored after contact with styrene for grafting. The post-irradiation time was established at 14 days when the films were remained in styrene/toluene 1:1 v/v. After this period the grafting degree was evaluated in the samples. The grafted films were sulfonated using chlorosulfonic acid and 1, 2-dichloroethane 20:80 (v/v) at room temperature for 5 h. The membranes were analyzed by infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermogravimetric measurements (TG) and degree of grafting (DOG). The ion exchange capacity (IEC) of membranes was determined by acid-base titration and the values for ETFE membranes were achieved higher than Nafion ® films. Preliminary single cell performance was made using pure H 2 and O 2 as reactants at a cell temperature of 80 °C and atmospheric gas pressure. The fuel cell performance of ETFE films was satisfactory when compared to state-of-art Nafion ® membranes.

Déconstruction-reconstruction identitaire et poétique de l’altérité dans Le procès-verbal de J-M G. Le Clézio

Directory of Open Access Journals (Sweden)

Abdoulaye Diouf

2016-12-01

Full Text Available En partant du double mouvement rhizomatique de la « déterritorialisation » et de la « reterritorialisation », cet article se propose d’étudier la conception dynamique de l’identité dans Le procès-verbal de Jean-Marie Gustave Le Clézio (1963. Pour cela, il explore, d’une part, le processus graduel de déconstruction identitaire du héros du roman (marginalité, nudité, métamorphose par le biais de la médiation altéritaire – dans le sens d’un rapport au monde et à l’Autre – à partir de laquelle se reconstruit une nouvelle identité transcendante loin de tout essentialisme. D’autre part, il analyse les différentes stratégies de mise en altérité qui montrent au passage, avec sa théorie de l’« extase matérialiste » et le principe de l’identification qui la sous-tend, que l’être ne s’arrête pas à l’humain chez Le Clézio. Starting from the dual rhizome-like movement of the “deterritorialization” and “reterritorialization”, this article proposes to study the dynamic concept of identity in Le procès-verbal by Jean-Marie Gustave Le Clézio (1963. For this, it explores, firstly, the gradual process of identity deconstruction of the novel’s hero (marginality, nudity, metamorphosis through the othering mediation - in the sense of a relationship to the world and the Other - from which is rebuilt a new transcendent identity away from all essentialism. Furthermore, it analyzes the different otherness implementation strategies that show the way, with his theory of “materialistic ecstasy” and the principle of identification which underlies it, according to which being goes beyond humans for Le Clézio.

Patrika - alt

Indian Academy of Sciences (India)

brilliant printers

the meeting from around the country a greater interaction with Fellows. There were sixteen 30-minutes ... development in plants; (e) experimental evolutionary biology; (f) discrete groups of ..... were provided by “deep ecology”, a doctrine of questionable intellectual .... pollination, dispersal, mutualisms etc. The advantage of.

Kulturen som krænkelsens virkelighed

DEFF Research Database (Denmark)

Brock, Steen

2006-01-01

En analyse af forholdet mellem natur og kultur i relation til en opfattelse af kultur, som har sin oprindelse i Cicero, og som har sin genklang i moderne tænkere som Goethe, Wittgenstein, Cavell og E. Wolfgang Orth.......En analyse af forholdet mellem natur og kultur i relation til en opfattelse af kultur, som har sin oprindelse i Cicero, og som har sin genklang i moderne tænkere som Goethe, Wittgenstein, Cavell og E. Wolfgang Orth....

A gestalt approach to the science fiction novels of William Gibson

OpenAIRE

McFarlane, Anna M.

2015-01-01

Gestalt psychologists Kurt Koffka and Wolfgang Köhler argue that human perception relies on a form, or gestalt, into which perceptions are assimilated. Gestalt theory has been applied to the visual arts by Rudolf Arnheim and to literature by Wolfgang Iser. My original contribution to knowledge is to use gestalt theory to perform literary criticism, an approach that highlights the importance of perception in William Gibson’s novels and the impact of this emphasis on posthumanism and science fi...

An integrated program of geophysical survey, coring, and test excavations to study a 4th millennium bc-cal ditch at Alt del Punxó (Muro de L’alcoi, Alacant

Directory of Open Access Journals (Sweden)

García Puchol, Otero

2008-06-01

Full Text Available The potentially long and interesting archaeological sequence revealed by systematic survey at the site of Alt Del Punxó (Muro de l’Alcoi, Alacant was the basis for initiating a study of the locality’s subsurface structures using new methods of remote sensing. Geophysical survey (magnetometry and tomography and systematic augering revealed buried structures, including monumental earthworks, and guided subsequent excavations to collect more detailed data about the nature and age of these prehistoric features. The information recovered, including new radiocarbon dates, offers a new perspective on the organization of prehistoric populations in this region of south-central Valencia since the beginning of the Holocene and is especially important for understanding the Neolithic IIB from the 4th through the early 3rd Millennium BC.

La amplia e interesante secuencia arqueológica sugerida por los materiales de superficie del yacimiento de Alt del Punxó (Muro de l’Alcoi, Alacant ha supuesto el punto de partida para la práctica de una serie de métodos de detección de las estructuras conservadas en el lugar. La prospección geofísica (magnetometría y tomografía, y los microsondeos (augers han dirigido la planificación de la excavación con el fin de obtener nuevos datos a propósito de la naturaleza y cronología del gran foso prehistórico, así como de las diversas estructuras localizadas. La información obtenida, junto a la serie radiocarbónica disponible, abre nuevas perspectivas para el estudio del poblamiento prehistórico al aire libre en las comarcas centro-meridionales valencianas desde los inicios del Holoceno, y de un modo particular en el IV e inicios del III milenio cal AC –Neolítico IIB.

Darbe Yükü Altındaki Hibrit Kompozit Plakalara Sıcaklığın Etkisi

Directory of Open Access Journals (Sweden)

Metin SAYER

2009-03-01

Full Text Available Bu çalışmada, karbon-cam elyaf/epoksi (hibrit kompozitlerin sıcaklık ve artan darbe enerjisi altındaki darbe davranışları incelenmiştir. Bununla ilgili olarak iki tip tabaka dizilim açısına sahip, 8 tabakalı hibrit kompozit numunelere -20, 0, 20 ve 40 oC sıcaklıklarında, numunelerde delinme meydana gelene kadar darbe enerjisi uygulanmıştır. Hibrit kompozitlerin saplanma ve delinme sınır değerlerinin belirlenmesinde, darbe enerjisi ve absorbe edilen enerji arasındaki ilişkiyi göstermede kullanılan enerji profili diyagramı kullanılmıştır. Bunun yanı sıra, maksimum temas kuvveti (Fmax, toplam çökme (d ve maksimum temas süresi (t gibi önemli darbe karakteristiklerinin sıcaklık geçişlerindeki değişimleri de sunulmuştur. Sonuç olarak, cam ve karbon fiberlerin -20 oC'de, diğer sıcaklıklara göre daha çok gevrekleştiği görülmüştür. Buna göre her iki tip hibrit kompozit için -20 oC'de meydana gelen delinme sınırı diğer sıcaklıklara göre en yüksek değerde bulunmuştur.

Effect of Heterogeneity of JSFR Fuel Assemblies to Power Distribution

International Nuclear Information System (INIS)

Takeda, Toshikazu; Shimazu, Yoichiro; Hibi, Koki; Fujimura, Koji

2013-01-01

Conclusion: 1) Strong heterogeneity of JSFR assemblies was successfully calculated by BACH. 2) Verification test of BACH: • Infinite assembly model; • Color set model; • Good agreement with Monte-Carlo results. 3) Core calculations 3 models for inner duct was used; inward model, outward model and homogeneous model. • k eff difference between the inward and out ward model → 0.3%Δk; • ~20% effect on flux and power distributions. Therefore, we have to pay careful attention for the location of inner duct in fuel loading of JSFR

Local supertwistors

International Nuclear Information System (INIS)

Merkulov, S.A.

1987-01-01

The geometry of local supertwistors is investigated. An ansatz on the form of the supertwistor superconnection is introduced. Because of this restriction on the form of such a superconnection the Yang-Mills equations for the superconnection turn out to be equivalent to the free Bach equations describing the dynamics of simple conformal supergravity. It is shown that the equations of motion of conformal supergravity interacting with a vector superfield admit an analogous interpretation. It is proved that an arbitrary conformally right-flat or left-flat superspace is automatically a solution of the Bach equations

Avaliação hematológica e dosagem bioquímica de ALT, AST e creatinina em elefante-marinho-do-sul, Mirounga leonina (linnaeus, 1758, encontrado no litoral de Salvador, Bahia

Directory of Open Access Journals (Sweden)

Bruno Lopes Bastos

2006-02-01

Full Text Available Since 1999 the Aquatic Mammals Rescue Center - AMRC has been working in the rescue and rehabilitation of stranded cetaceans and pinnipeds on the coast of Bahia, Brazil. This paper presents and analyses the blood cells count and clinical chemistry of alanine aminotransferase (ALT, aspartate aminotransferase (AST and creatinine of a southern elephant seal, Mirounga leonina (LINNAEUS, 1758, found on February the 11th at Barra Beach, Salvador, BA. The specimen was an orphan male calf, with 137cm of length and estimated weight of 49kg. It presented bad nutritional conditions and a shark bite on the right shoulder area. Clinical management was performed for 56 days, anthelmintic Febendazole was utilized, and the bite was treated with iodined alcohol, Nitrofurazone solution and Kethanserin, simultaneously with Enrofloxacin 10%, Potenay®, Vitamin B Complex and Benerva®. On the 16th the animal presented a right unilateral conjuntivitis, treated with Cloranphenicol oftalmic pomade until the end of its stay in the captive. During this period a total of six blood samples were collected, three for total blood counts and the others for the biochemistry determination of ALT, AST and creatinine. According to the haematological analysis the seal developed an anaemia which was classified as microcytic and normochromic. Lymphopenia, eosinopenia and monocytopenia were also observed, possibly due to its handling and stress conditions. The clinical chemistry presented low values for AST and creatinine, although this did not represent the existence of any pathologic context or disease with clinical significance.

Deprem Yükleri Altında Kalıcı Şev Deplasmanlarının Tahmini

Directory of Open Access Journals (Sweden)

Deniz ÜLGEN

2014-09-01

Full Text Available Dinamik yükleme altındaki şevlerin stabilitesi genel olarak yarı-statik analiz yöntemi kullanılarak incelenir. Bu yöntem, belirli bir güvenlik katsayısını dikkate almakla birlikte, oluşan kalıcı deplasmanlar hakkında bir bilgi vermemektedir. Newmark, güçlü deprem hareketlerine maruz kalan şevlerin kalıcı deplasmanlarının tahmini için bir analiz yöntemi önermiştir. Bu çalışmada, saha şartları ve deprem özellikleri dikkate alınarak şevlerin davranışı dinamik analizlerle irdelenmiştir. Bu analizlerde, çeşitli gerçekçi şev modelleri seçilerek sonlu elemanlar yöntemi kullanılmıştır. İlk olarak, şevlerdeki potansiyel kayma yüzeyleri, basitleştirilmiş Bishop metoduyla belirlenmiştir. Daha sonra, kayma yüzeylerinin kritik ivmeleri ve maksimum ortalama etkin ivmeleri bulunarak, Newmark yöntemiyle şevlerin kalıcı deplasmanları hesaplanmıştır. Son olarak, deprem kaynaklı kalıcı şev deplasmanlarının ön tahmini için basit bir grafik ve formülasyon önerilmiştir

Thermal load distribution on the ALT-II limiter of TEXTOR-94 during RI mode operation and during disruptions

International Nuclear Information System (INIS)

Finken, K.H.; Denner, T.; Mank, G.

2000-01-01

Thermographic measurements using an IR scanner have been performed at the pump limiter ALT-II of TEXTOR-94 during RI mode discharges and during disruptions. The measurements on the RI mode discharges were done to complete the TEXTOR database which had shown a structured decay pattern of the deposited power. It was found that the underlying radial heat flux can be described by two exponential decay functions. This structure, which generates an unexpected heat component close to the tangent line, has been observed in all discharge conditions including the RI mode. During disruptions, the heat is released in short pulses with a typical duration of 0.01-0.1 ms. The radial decay length of these pulses has a similar shape to the heat flux during normal discharges: it consists again of a strong component close to the tangent line with a radial decay length of 2-5 mm and probably one with a decay length of the order of 1 cm. The heat is released at the time when the edge electron temperature of the plasma drops, when intense hydrogen and carbon fluxes occur near the walls, and when electrical currents in the limiter blades are excited. In a tentative interpretation, the temporal and spatial structure of the heat pulse is attributed to the presence and growth of a laminar zone at the plasma edge, which is connected with the ergodization of the plasma edge during a disruption. (author)

CERN Library | Cecilia Jarlskog presents "Portrait of Gunnar Källén: a physics shooting star and poet of early quantum field theory" | 16 September

CERN Multimedia

2014-01-01

Wolfgang Pauli referred to him as 'my discovery', Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)?   His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigour in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: "Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying ...

Plastic fish

CERN Multimedia

Antonella Del Rosso

2015-01-01

In terms of weight, the plastic pollution in the world’s oceans is estimated to be around 300,000 tonnes. This plastic comes from both land-based and ocean-based sources. A lecture at CERN by chemist Wolfgang Trettnak addressed this issue and highlighted the role of art in raising people’s awareness.   Artwork by Wolfgang Trettnak. Packaging materials, consumer goods (shoes, kids’ toys, etc.), leftovers from fishing and aquaculture activities… our oceans and beaches are full of plastic litter. Most of the debris from beaches is plastic bottles. “PET bottles have high durability and stability,” explains Wolfgang Trettnak, a chemist by education and artist from Austria, who gave a lecture on this topic organised by the Staff Association at CERN on 26 May. “PET degrades very slowly and the estimated lifetime of a bottle is 450 years.” In addition to the beach litter accumulated from human use, rivers bring several ki...

La sémantique du stereotype et la representation topique de l’altérité

Directory of Open Access Journals (Sweden)

Afsaneh Pourmazaheri

2017-12-01

Full Text Available Ce travail de recherche s’interroge sur la représentation discursive des référents exotiques filtrée par un regard stéréotypé dans les récits de trois voyageurs français en Orient de la première moitié du XIXe siècle. Les énonciateurs-voyageurs, placés dans un contexte linguistique et culturel asymétrique, tentent de saisir et de transcrire leurs observations sur le terrain étranger en fonction de leur intellect, de leur cognition et de leur expérience. Une série d’éléments marqués par l’altérité viennent modifier la représentation que l’auteur-voyageur donne du référent et de l’univers référentiel auquel il est confronté. C’est à cette façon « réductrice » de voir les référents issus d’un univers différent et à l’intervention de la subjectivité de l’auteur que nous nous intéressons dans cette étude. Nous analysons les effets discursifs produits par l’usage des ressources linguistiques ainsi que par les positionnements énonciatifs des auteurs-voyageurs. Cette approche homogénéisante et généralisante de la perception de l’Autre se fait au travers des moules préconstruits et une démarche subjective dans la culture réceptrice que nous tenterons de voir à l’aide des outils d’analyse langagiers et discursifs dans les récits de voyage de Goupil Fesquet (1844, de Rémy Aucher-Eloy (1843 et de J.M. Tancoigne (1819 en Orient, notamment en Perse.

Koncept implikovaného čtenáře v teorii Wolfganga Isera

OpenAIRE

Berková, Pavlína

2016-01-01

The Bachelor thesis titled "The Concept of Implied Reader in Wolfgang's Iser Theory" aims to introduce the concept of implied reader, which played the key role in the theory of reception aesthetician Wolfgang Iser. In the beginning the thesis is focused on the context of Iser's works, i.e. the Constance School of reception aesthetics and its main ideas, then introduces the concept of implied reader itself. Iser is using this term to capture the nature of the interactions that take place in th...

Los visitantes del Parc Natural de l’Alt Pirineu y la práctica de actividades recreativo-deportivas. una propuesta de segmentación

Directory of Open Access Journals (Sweden)

Farías, E. I.

2014-12-01

Full Text Available In recent years there has been a large increase in the practice of recreational and sports activities in protected natural areas. As part of the planning and management of public use of these areas, is essential to a deeper understanding of the characteristics of the visitors. This study analyzes the characteristics of the different segments of visitors to Alt Pirineu Natural Park based on recreational and sports activities practiced. For this study, 1.600 surveys were conducted in 16 sampling points over a calendar year between the months of July 2010 and June 2011. In total we identified eight segments of visitors based on physical activity: walkers, recreational hikers, hikers, mountaineer, cyclists, mushroom picker, off road driver and skier. The results obtained here are discussed in terms of their possible applicability in the management of public use of this park and other protected natural areas and also for the development of management strategies and awareness campaigns aimed at different segments of visitors.En los últimos años se ha registrado un gran incremento en la práctica de las actividades recreativodeportivas en los espacios naturales protegidos. En el marco de la planificación y la gestión del uso público de este tipo de espacios, resulta fundamental profundizar en el conocimiento de las características de los visitantes. En este estudio se analiza el perfil de los diferentes segmentos de visitantes del Parc Natural de l’Alt Pirineu en base a las actividades recreativo-deportivas practicadas. Para este estudio se realizaron 1.600 encuestas en 16 puntos de muestreo, a lo largo de un año natural comprendido entre los meses de Julio de 2010 y Junio de 2011. En total se identificaron ocho segmentos de visitantes en función de la actividad física: paseantes, excursionistas, senderistas, montañistas, ciclistas, recolectores de setas, motoristas y esquiadores. Los resultados aquí obtenidos son discutidos en t

Riedel, Wolfgang; Lange, Horst (Hrsg.): Landschaftsplanung

OpenAIRE

Schlosser, Siegfried

2013-01-01

Endlich liegt für einen breiten Nutzerkreis ein aktuelles, alle wesentlichen Bereiche der Landschaftsplanung behandelndes Lehrbuch vor! Erfreulich auch, dass durch die langjährige berufliche Tätigkeit mehrerer beteiligter Autoren im Osten Deutschlands, insbesondere der beiden Herausgeber, viele Erfahrungen aus der Landschaftsplanung der neuen Bundesländer mit einbezogen werden konnten.

Portrait of Gunnar Källén a physics shooting star and poet of early quantum field theory

CERN Document Server

2014-01-01

Wolfgang Pauli referred to him as 'my discovery,' Robert Oppenheimer described him as 'one of the most gifted theorists' and Niels Bohr found him enormously stimulating. Who was the man in question, Gunnar Källén (1926-1968)? His appearance in the physics sky was like a shooting star. His contributions to the scientific debate caused excitement among young and old. Similar to his friend and mentor, Wolfgang Pauli, he demanded honesty and rigor in physics - a distinct dividing line between fact and speculation. In his obituary, Arthur S. Wightman would write: 'Gunnar Källén was a proud continuer of the tradition in quantum field theory established by Wolfgang Pauli. His papers on quantum electrodynamics in the period 1950-1954 carried the non-perturbative approach to quantum electrodynamics forward to a point beyond which very little essential progress has been made up to the present day. At the time I was trying to puzzle out the grammar of the language of quantum field theory, and here was Källén al...

Om guldbiller, Bach og basepar

DEFF Research Database (Denmark)

Mogensen, T.E.

2003-01-01

I sin stærkt encyklopædiske roman The Gold Bug Variations søger den amerikanske forfatter Richard Powers gennem utallige detaljer, synekdoker og intrikate forbindelser at inddrage al verden og radikalt udvide romanens rum. Men romanen er også, eller især, en fortælling om kærlighed....

Enhanced optophysical properties of poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3] thiadiazol-4,8-diyl)] via addition of TiO{sub 2} nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Fuzi, Siti Aishah Ahmad, E-mail: aishah-fuzi@yahoo.com; Jumali, Mohammad Hafizuddin Hj, E-mail: hafizhj@ukm.edu.my; Al-Asbahi, Bandar Ali Abdulqader, E-mail: alasbahibandar@gmail.com [School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor. Malaysia (Malaysia)

2015-09-25

This work investigated the effect on 5 wt% addition of TiO{sub 2} nanoparticles (NPs) on the optical absorption characteristics of Poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3] thiadiazol-4,8-diyl)] (F8BT). Both materials were mixed using solution blending method and then spin coated onto ITO-coated glass substrate at 1000 rpm for 30s. The optical properties of the nanocomposite were determined using UV-Vis spectroscopy. Compares to pristine film, the absorption peak of the nanocomposite film improved and shifted to longer wavelength indicating reduction in the direct and indirect band gaps. Better optophysical properties of F8BT/TiO{sub 2} nanocomposites is believed due to compatible band structures and efficient charge trapping effect displayed by the NPs.

Investigations into the chemistry, toxicology, metabolism and possible mode of action of O-ethyl S-methyl ethylphosphonothioate

International Nuclear Information System (INIS)

Hur, J.H.

1989-01-01

The chemical and metabolic oxidation of O-ethyl S-methyl ethylphosphonthioate (1) as a model compound was studied. This compound has the following toxicological properties: LD 50 (rat) 4.6 mg/kg, LD 50 (HF) 14.0 ug/g; k i (BAChE) = 303, k i (HFAChE) = 623. 13 C- and 31 P-NMR were mainly used in this study. The chemical oxidation of 1 with m-CPBA in CDCl 3 resulted in the formation of O-ethyl ethylphosphonic acid (2), O-ethyl ethylphosphinyloxymethylsulfonate (3) and O-ethyl ethylphosphonic acid anhydride (4). However, oxidation reaction of the model compound 1 with MPPA in D 2 O gave 2 and methylsulfonic acid. 1 was incubated in vitro with rat liver microsomal oxidase, and 2 and methylsulfenic acid were observed along with 1. For the in vivo study, a number of houseflies were treated with 14ug/g (LD 50 level) of 1. Analysis of the extracts of metabolic products provided evidence of the formation of 2. The existence of 1 S-oxide was demonstrated by use of a trapping method and the observation of oxidation products. The S-oxide has been proposed as a possible active intermediate responsible for the high toxicity of 1 to animals. However, owing to its instability it is unlikely that the S-oxide intermediate would persist in an aqueous biological environment long enough to attack the target enzyme. 4 was shown to have high toxicity to the rat and housefly and was also a potent anticholinesterase against BAChE and HFAChE . The presence of 4 was observed directly by the monitoring experiments during the chemical oxidation in aqueous conditions. This provided evidence that this metabolite is stable enough to attack the target site in biological systems. The anhydride 4 is proposed as the active metabolite in in vivo systems, responsible for high toxicity of 1

A study on the morphology of polystyrene-grafted poly(ethylene-alt-tetrafluoroethylene) (ETFE) films prepared using a simultaneous radiation grafting method

International Nuclear Information System (INIS)

Song, Ju-Myung; Ko, Beom-Seok; Sohn, Joon-Yong; Nho, Young Chang; Shin, Junhwa

2014-01-01

The morphology of polystyrene-grafted poly(ethylene-alt-tetrafluoroethylene) (ETFE) films prepared using a simultaneous radiation grafting method was investigated using DMA, DSC, XRD, and SAXS instruments. The DMA study indicates that the ETFE amorphous phase and PS amorphous phase are mixed well in the PS-grafted ETFE films while the ETFE crystalline phase and the PS amorphous phase are separated, suggesting that the PS chains are grafted mainly on the ETFE amorphous regions. The DSC and XRD data showed that the natural crystalline structures of ETFE in the grafted ETFE films are not affected by the degree of grafting. The SAXS profiles displayed that the inter-crystalline distance of the ETFE films increases with an increasing degree of grafting, which further implies that the PS graft chains formed by the simultaneous irradiation has a significant impact on the amorphous morphology of the resulting grafted ETFE film. Thus, these results indicate that the styrene monomers are mainly grafted on the ETFE amorphous regions during the simultaneous radiation grafting process. - Highlights: • PS-grafted ETFE films were prepared by a simultaneous radiation grafting method was investigated. • The natural crystalline structures of grafted ETFE films are not affect by the degree of grafting. • The inter-crystalline distance of the ETFE films increase with increasing degree of grafting. • The styrene monomers are mainly grafted on the ETFE amorphous regions during a simultaneous radiation grafting using gamma-ray

Kontserdijärgseid mõtteid / Niina Murdvee

Index Scriptorium Estoniae

Murdvee, Niina, 1950-

1999-01-01

Ü. Kaadu esinemisest 29. aprillil Estonia kontserdisaalis. Kavas Tshaikovski Viiulikontsert. M. Mikalai ja O. Voronova ühiskontserdist 30.aprillil Tallinna raekojas. Kavas Bach, Debussy, Liszt, Eller ja Ravel

Plaadid / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2008-01-01

Uutest heliplaatidest Lightspeed Champion "Falling Off The Lavender Bridge", Sebastian Bach "Angel Down", Juanes "La Vida...", raadi Maria "Siin Tallinn", Erich Krieger "Live", Rock Hotel "Rock Hotel Rock Cafes"

Ways to live history. Or philosophy, culture, and architecture in the origins of the museum Altes in Berlín Formas de habitar la historia. O la filosofía, la cultura y la arquitectura en la fundación del Museo Altes de Berlín Modos de habitar a história ou Filosofia, cultura e arquitetura na fundação do Altes Museum de Berlim

Directory of Open Access Journals (Sweden)

Fabiano Lemos

2011-01-01

Full Text Available From the beginnings of what we now know as our modernity, man has been surprised with his own finitude. The 18^th and 19^th  century bourgeois needed to formulate complex ways of preserving the past and of linking with it. In the philosophes’ circle, time concept starts to double itself in the idea of origin, that, for them, had become opaque. We just need to think of the broad-range process of structuring museums and restructuring natural history collections in cities such as Paris and Berlin, around the turn to the 19^th century, so that we can be convinced that the surprise with that origin that one cannot recognize anymore, that becomes object of popular and scientific interest, leads each and all of the decisions in this process. Museum is just one of the institutions in which man, through a complex series of idealizations of space, show himself the spectacle of a lost time and, thus, of a culture whose educational thrive can only be understood by associating to these institutions. Our task is to investigate – and the case study of the grounding of the Altes Museum in Berlin, between 1822 and 1830, will perform this concretely – which educational policy made the emergence of this new ideological model possible, and , on the opposite way, which conceptual elaborations confirmed or legitimated the new pragmatic topography of time in modernity within the institution that had as aim, precisely, articulate and administrate past and memory. Desde los albores de la modernidad tal como la entendemos hoy en día, el hombre se espanta por su finitud. El burgués de los siglos XVIII y XIX tuvo que crear mecanismos complejos para la preservación del pasado y su relación con él. En el círculo de philosophes, la noción del tiempo comienza a replicarse en la idea de origen, que para ellos se convirtió en opaca. Basta pensar en el amplio

Pop / Lauri Tikerpe

Index Scriptorium Estoniae

Tikerpe, Lauri

2008-01-01

Heliplaatidest: Damian Jr. Gong Marley "Mr. Marley", Sebastian Bach "Angel Down", Stereophonics "Pull The Pin", Dahling "Dahling", Led Zeppelin "Mothership", Jack Penate "Matinee", Bugge Wesseltoft "Im", David Gray "Greatest Hits"

Advendikontsert Bachi muusikaga. Folk ja pärimusmuusika Vanemuises / Jaanika Juhanson

Index Scriptorium Estoniae

Juhanson, Jaanika, 1977-

1999-01-01

Eelinfo 12. dets. Adamson-Ericu muuseumis toimuvast kontserdist sarjas "Bach - 250 aastat surmast". Viljandi pärimusmuusika festival korraldab 12. dets. Vanemuise kontserdimajas kontserdi "Meel unus mägede taha"

Commentary on "Asynchronous Preparation of Tonally Fused Intervals in Polyphonic Music" by David Huron

Directory of Open Access Journals (Sweden)

James Wright

2008-05-01

Full Text Available In his most recent contribution to an important and well-framed series of papers on auditory grouping and the perception of polyphonic music, David Huron seeks further evidence for his working hypothesis that J.S. Bach controls the employment of perfect consonances by desynchronizing their onsets, thereby inhibiting the perceptual fusion of polyphonic voices. However the more novel contribution of the present study would seem to be its demonstration that Bach also regulates the employment of dissonant tones by consistently desynchronizing their onsets. This finding provides the first concrete evidence for Wright and Bregman’s otherwise untested hypothesis that the control and salience of dissonance in polyphonic music are closely related to principles of auditory stream segregation (Wright, 1986; Wright & Bregman, 1987.

Muusikamaailm / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

Wolfgang Wagner loobub Bayreuthi festivalist, "Towards the Millennium" Londonis, Kammerkontserdite mammutsari Põhja-Rhein-Westfaali liidumaal, Kreneki päevad Viinis, Leipzigi ooperi järgmine hooaeg

Pauli and Jung the meeting of two great minds

CERN Document Server

Lindorff, David

2004-01-01

The pioneering work of Nobel prize-winning physicist Wolfgang Pauli led to developing the bombs that decimated Hiroshima and Nagasaki. Desperate over this outcome, Pauli sought help from the eminent depth psychologist, C. G. Jung. Their long correspondence provides the powerful and unique record of a mature scientist's inner journey. It also has had a tremendous impact on scientific and psychological thought ever since. Pauli and Jung is a lucid interpretation of Pauli's ideas and dreams that forcefully validates his belief in the inseparable union of science and spirituality. Far ahead of their time, Wolfgang Pauli and C. G. Jung both knew this union is essential for the future of humanity and the survival of the planet.

on the proliferation, differentiation and tube formation of endothelial

African Journals Online (AJOL)

Yomi

2011-12-21

- tions and plays an important role in intercellular adhesion and cell differentiation, growth and migration (Dejana et al., 1999)). VE-cadherin also has been implicated in vasculogenesis and angiogenesis (Bach et al., 1998).

Evolutionary Diversification of Alanine Transaminases in Yeast: Catabolic Specialization and Biosynthetic Redundancy

Directory of Open Access Journals (Sweden)

Ximena Escalera-Fanjul

2017-06-01

Full Text Available Gene duplication is one of the major evolutionary mechanisms providing raw material for the generation of genes with new or modified functions. The yeast Saccharomyces cerevisiae originated after an allopolyploidization event, which involved mating between two different ancestral yeast species. ScALT1 and ScALT2 codify proteins with 65% identity, which were proposed to be paralogous alanine transaminases. Further analysis of their physiological role showed that while ScALT1 encodes an alanine transaminase which constitutes the main pathway for alanine biosynthesis and the sole pathway for alanine catabolism, ScAlt2 does not display alanine transaminase activity and is not involved in alanine metabolism. Moreover, phylogenetic studies have suggested that ScALT1 and ScALT2 come from each one of the two parental strains which gave rise to the ancestral hybrid. The present work has been aimed to the understanding of the properties of the ancestral type Lacchancea kluyveri LkALT1 and Kluyveromyces lactis KlALT1, alanine transaminases in order to better understand the ScALT1 and ScALT2 evolutionary history. These ancestral -type species were chosen since they harbor ALT1 genes, which are related to ScALT2. Presented results show that, although LkALT1 and KlALT1 constitute ScALT1 orthologous genes, encoding alanine transaminases, both yeasts display LkAlt1 and KlAlt1 independent alanine transaminase activity and additional unidentified alanine biosynthetic and catabolic pathway(s. Furthermore, phenotypic analysis of null mutants uncovered the fact that KlAlt1 and LkAlt1 have an additional role, not related to alanine metabolism but is necessary to achieve wild type growth rate. Our study shows that the ancestral alanine transaminase function has been retained by the ScALT1 encoded enzyme, which has specialized its catabolic character, while losing the alanine independent role observed in the ancestral type enzymes. The fact that ScAlt2 conserves 64

Risk-taking under progressive taxation

OpenAIRE

Bamberg, Günter

1988-01-01

Risk-taking under progressive taxation : 3 partial effects / Günter Bamberg ; Wolfram R. Richter. - In: Measurement in economics / ed. by Wolfgang Eichhorn. - Heidelberg : Physica-Verl., 1988. - S. 479-497

Välismaalt

Index Scriptorium Estoniae

2000-01-01

Covent Garden pärast remonti; Porisse tahetakse rajada dzhässi ja rokimuuseumi; Bach ja Ameerika; Vene piirivalvevägedele oma hümn; muusikalide buum Saksamaal saab otsa; endised kuulsused surid detsembris

Effects of Sunlight Exposure on the Quality Parameters of Bottled ...

African Journals Online (AJOL)

PROF HORSFALL

microbial population (total coliform) of the bottled water with increasing exposure to sunlight was observed. ... safe drinking water which has led to the tremendous ... degradation under high temperature (Bach et al., ..... Solar and photocatalytic.

Muusika

Index Scriptorium Estoniae

2005-01-01

EMA kammersaalis avatakse Veljo Tormise regilaulukeskus ja esitatakse DVDd "Tegelik regilaulmine". Agentuuri Corelli Music kontserdisarja "Ajaloo ilu - J. S. Bach" kontsertidest. Pille Lille Muusikute Toetusfond korraldab sarjas "Hingemuusika" Otepää Maarja kirikus kontserdi

The de Sitter spacetime as an attractor solution in fourth-order gravity

International Nuclear Information System (INIS)

Schmidt, H.-J.

1988-01-01

We investigate the general vacuum solution of fourth-order gravity, and include the Bach tensor. For L 2 = 1.3μR 2 + 1/2αC 2 the expanding de Sitter spacetime is an attractor in the set of axially symmetric Bianchi type-I models if and only if αμ ≤ 0 or α > 4μ holds. It will be argued that this result holds true for a large class of inhomogeneous models. As a byproduct, a new closed-form cosmological solution, is obtained. It is also shown that the de Sitter spacetime is an attractor for the Bach-Einstein gravity with a minimally coupled scalar field φ. Specialised to Einstein gravity (i.e. α = 0 above) this conformal equivalence remains a non-trivial one. (author)

Kaks paljast ja kaks riides meest / Kätlin Kaldmaa

Index Scriptorium Estoniae

Kaldmaa, Kätlin, 1970-

2007-01-01

18.-31. augustini Tallinnas Kanuti Gildi saalis toimunud Augusti tantsufestivali lavastustest : Frans Poelstra ja Robert Steijni "Frans Poelstra, his dramaturge and Bach" ja Jordi Cortési ja Damian Munozi "Hõõguvad söed"

Alt-Az Spacewatch Telescope

Science.gov (United States)

Gehrels, Tom

1997-01-01

This grant funded about one third of the cost of the construction of a telescope with an aperture 1.8 meters in diameter to discover asteroids and comets and investigate the statistics of their populations and orbital distributions. This telescope has been built to the PI's specifications and installed in a dome on Kitt Peak mountain in Arizona. Funds for the dome and building were provided entirely by private sources. The dome building and telescope were dedicated in a ceremony at the site on June 7, 1997. The attached abstract describes the parameters of the telescope. The telescope is a new item of capital property. It is permanently located in University of Arizona building number 910 in the Steward Observatory compound on Kitt Peak mountain in the Tohono O'odham Nation, Arizona. fts property tag number is A252107. This grant did not include funds for the coma corrector lens, instrument derotator, CCD detector, detector electronics, or computers to acquire or process the data. It also did not include funds to operate the telescope or conduct research with it. Funds for these items and efforts are pending from NASA and other sources.

Astrofisica delle alte energie

CERN Document Server

Vietri, Mario

2006-01-01

L'insegnamento dell'astrofisica moderna richiede conoscenze di base di svariate discipline, oltre ad alcuni modelli fondamentali. Lo scopo di questo libro è di presentare sia le une che gli altri in maniera possibilmente esaustiva, e di essere dunque utilizzabile sia come prima introduzione alle problematiche astrofisiche, sia come testo di riferimento ulteriore per giovani studiosi.

Alt koster 10 kr

DEFF Research Database (Denmark)

Ejersbo, Lisser Rye

2014-01-01

Jeg havde engang en elev, som fortalte, at når han gik i byen for at købe ind, så var det nemt at beregne, om han havde nok penge med i byen. Han sagde bare, at alle varerne kun kostede 10 kr. Det kan lyde som lidt af en tilsnigelse, så klassen og jeg besluttede at undersøge om hans metode virkede....

Riget - alt er tilladt

DEFF Research Database (Denmark)

2017-01-01

Riget indtager en nøglestilling, når overgangen mellem faser i Triers produktion skal karakteriseres. Riget danner bro mellem den billedfascination og de radikale stileksperimenter, der præger Triers tidlige produktion, og den genre- og plotbevidsthed, der er typisk for film som Breaking the Waves...

Stravinsky, Igor: Le Sacre du Printemps / Pierre-E. Barbier

Index Scriptorium Estoniae

Barbier, Pierre-E.

1996-01-01

Uuest heliplaadist "Stravinsky, Igor: Le Sacre du Printemps. Requiem Canticles. Canticum sacrum. Variations sur un choral de Bach. Orchestre de la Suisse Romande, Neeme Järvi" Chandos CHAN 9 408, distribution Media 7 (SD:160F)

Uudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2013-01-01

Lühisõnumeid muusikamaailmast: Van Cliburn. Wolfgang Sawallisch. Marie-Claire Alain. New Yorgi Metropolitan Opera uudiseid. Mihhail Pletnjov taas laval. Frankfurdi raadio sümfooniaorkestri uus peadirigent. Jāzeps Vītols 150.

Eurost on saanud dollari tugev konkurent kiiremini kui arvati / Erik Aru

Index Scriptorium Estoniae

Aru, Erik

2008-01-01

USA majandusprofessorite Jeff Frankeli ja Menzie Chinni arvutuste kohaselt võib eurost saada dollari asemel rahvusvaheline valuuta 2015. aastal. Kolumnist Wolfgang Münchau hinnang. Lisa: USA majandussurutis vähendab rahavooge. Diagramm

The work of Daphne Hampson: The God talk of one feminist ...

African Journals Online (AJOL)

p1243322

of biblical scholarship and the mass of popular religious literature make abundantly clear ...... speaking about God propounded by, for example, Paul Tillich and John ..... London: Collins. Boeve .... Schaberg, J, Bach, A & Fuchs, E 2004. On the ...

Integrating Unmanned Aerial Vehicles (UAVs) With Current Combat Search and Rescue (CSAR) Doctrine

National Research Council Canada - National Science Library

Altieri, Jayson

2003-01-01

0300 hours (Zulu) somewhere north of Baghdad Major Chris Foster, call sign BACH-21, was flying a CAP mission supporting two flights of Air Guard F-16s attacking an Iraqi armor division retreating south towards Baghdad...

Effect of variation of precursor concentration on structural ...

Indian Academy of Sciences (India)

purpose of control and safe applications in domestic and industrial fields ... particles are particularly interesting for applications in .... nia, chlorine and hydrogen. Values .... 216 505. Bach U, Lupo D, Comte P, Moser J A, Weissortel F, Salbeck J,.

K polyfonní struktuře Preludia ze Suity c moll pro loutnu Johanna Sebastiana Bacha /BWV 997/

Czech Academy of Sciences Publication Activity Database

Kordík, Pavel

XXXVII, 1/2 (2000), s. 102-110 ISSN 0018-7003 Institutional research plan: CEZ:AV0Z8059909 Keywords : Johann Sebastian Bach * the Prelude from the Suite c-minor * polyphonous structure Subject RIV: AL - Art, Architecture, Cultural Heritage

Historic physics reprints come home : six boxes of historic reprints have returned home to Pauli's Library

CERN Multimedia

Maximilien Brice

2005-01-01

The 146 items - preprints by Born, Bohr, Heisenberg and others some with dedications to Pauli from the author - had been part of the personal library of the Nobel prize-winning physicist, Wolfgang Pauli.

Raamatud

Index Scriptorium Estoniae

2006-01-01

2006. a. Tallinnas kirjastuselt Tormikiri ilmunud Wolfgang Seitzi raamatust "Puidust kujunduselemendid koduaias", kirjastuselt Egmont Estonia ilmunud Brigitte Kleinodi raamatust "Koduaia arukas kujundamine", kirjastuselt Maalehe Raamat ilmunud Mart Ojasalu raamatust "Roosiaed : roosid - lilleilu liidrid"

Rembrandt Goethe kogust

Index Scriptorium Estoniae

1999-01-01

Rembrandti majamuuseum Amsterdamis Rembrandt-Huis tähistab Johann Wolfgang von Goethe 250. sünniaastapäeva 18. juulini avatud 17. sajandi hollandi graafika väljapanekuga "Goethe ja Rembrandt. Joonistused Weimarist"

Goethe and the Aurora

Science.gov (United States)

Schröder, Wilfried

2008-05-01

Johann Wolfgang von Goethe (1749-1832) was deeply interested in many aspects of natural science, including geology and meteorology. Thus, it is not surprising that his works include frequent references to natural phenomena.

Steam generator corrosion 2007; Dampferzeugerkorrosion 2007

Energy Technology Data Exchange (ETDEWEB)

Born, M. (ed.)

2007-07-01

Between 8th and 9th November, 2007, SAXONIA Standortentwicklungs- und -verwertungsgesellschaft GmbH (Freiberg, Federal Republic of Germany) performed the 3rd Freiberger discussion conference ''Fireside boiler corrosion''. The topics of the lectures are: (a) Steam generator corrosion - an infinite history (Franz W. Alvert); (b) CFD computations for thermal waste treatment plants - a contribution for the damage recognition and remedy (Klaus Goerner, Thomas Klasen); (c) Experiences with the use of corrosion probes (Siegfried R. Horn, Ferdinand Haider, Barbara Waldmann, Ragnar Warnecke); (d) Use of additives for the limitation of the high temperature chlorine corrosion as an option apart from other measures to the corrosion protection (Wolfgang Spiegel); (e) Current research results and aims of research with respect to chlorine corrosion (Ragnar Warnecke); (f) Systematics of the corrosion phenomena - notes for the enterprise and corrosion protection (Thomas Herzog, Wolfgang Spiegel, Werner Schmidl); (g) Corrosion protection by cladding in steam generators of waste incinerators (Joerg Metschke); (h) Corrosion protection and wear protection by means of thermal spraying in steam generators (Dietmar Bendix); (i) Review of thick film nickelized components as an effective protection against high-temperature corrosion (Johann-Wilhelm Ansey); (j) Fireproof materials for waste incinerators - characteristics and profile of requirement (Johannes Imle); (k) Service life-relevant aspects of fireproof linings in the thermal recycling of waste (Till Osthoevener and Wolfgang Kollenberg); (l) Alternatives to the fireproof material in the heating space (Heino Sinn); (m) Cladding: Inconal 625 contra 686 - Fundamentals / applications in boiler construction and plant construction (Wolfgang Hoffmeister); (n) Thin films as efficient corrosion barriers - thermal spray coating in waste incinerators and biomass firing (Ruediger W. Schuelein, Steffen Hoehne, Friedrich

Integrating Unmanned Aerial Vehicles (UAVs) With Current Combat Search and Rescue (CSAR) Doctrine

National Research Council Canada - National Science Library

Altieri, Jayson

2003-01-01

.... BACH-21 whipped his plane over into a left SAM break. As G-forces began to press against him, he felt his aircraft shake violently and continued to roll inverted as an SA-6 slammed into his right wing...

Kuu filmid / toimetanud Maria Ulfsak-Šeripova

Index Scriptorium Estoniae

2011-01-01

Nicolas Winding Refni krimidraama "Ohtlik sõit" (USA 2011), Pedro Almodovari "tume melodraama" "Nahk, milles ma elan" (Hispaania 2011). Wolfgang Amadeus Mozarti "Don Giovanni" Tallinnas (Coca-Cola Plaza), Tartus (Ekraan) ja Narvas (Astri kinos)

The philosophy of Hans-Georg Gadamer / Wolfgang Drechsler

Index Scriptorium Estoniae

Drechsler, Wolfgang, 1963-

1998-01-01

Rets.rmt.: The philosophy of Hans-Georg Gadamer : a review of the philosophy of Hans-Georg Gadamer / Lewis Edwin Hahn, ed. Chicago and La Salle, IL: Open Court, 1997. (The Library of Living Philosophers, vol. XXIV)

Wave Heating of the Solar Chromosphere Wolfgang Kalkofen

Indian Academy of Sciences (India)

Abstract. The nonmagnetic interior of supergranulation cells has been thought since the 1940s to be heated by the dissipation of acoustic waves. But all attempts to measure the acoustic flux have failed to show suffi- cient energy for chromospheric heating. Recent space observations with. TRACE, for example, have found ...

Keskklassi meistrivõistlused / Wolfgang König, Dirk Branke

Index Scriptorium Estoniae

König, Wolfgang

2012-01-01

Suur test. Mõõtu võtavad 15 pereautot: Audi A4 2.0 TDI, BMW 318d, Mercedes-Benz C 200 CDI, Škoda Superb 2.0 TDI, VW Passat 2.0 TDI, Citroën C5 HDi 140, Hyundai i40 1.7 CRDi, Ford Mondeo 2.0 TDCi, Kia Optima 1.7 CRDi, Mazda 6 2.2 MZR-CD, Opel Insignia 2.0 CDTI, Renault Laguna dCi 150, Peugeot 508 HDi 140, Volvo S60 D3, Seat Exeo 2.0 TDI

Saksa planeerimisõiguse olulised põhijooned / Wolfgang Ewer

Index Scriptorium Estoniae

Ewer, Wolfgang

2006-01-01

Lisatud: väljavõtteid Saksamaa Liitvabariigi põhiseadusest, ehitusseadustikust, ruumilise planeerimise seadusest, ehitusliku maakasutuse määrusest. - Lisatud: W. Eweri curriculum vitae ja publikatsioonide nimestik

Understanding the Dynamic System of Terrorist-Government Interaction

Science.gov (United States)

2003-03-01

Figure 62. Model 5D Equation Level Screen Shot 3 167 Bibliography Bajaracharya, Arun, Stephen Olu Ogunlana, and Nguyen Luong Bach...Understanding the New Security Environment Readings and Interpretations. Guilford, Connecticut: Mc- Graw -Hill/Dushkin 2002 Laqueur, Walter. “Postmodern

75 FR 40851 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Connected Media...

Science.gov (United States)

2010-07-14

... of antitrust plaintiffs to actual damages under specified circumstances. Specifically, Warner Music Group, New York, NY; Push Entertainment LTD., Bath, UNITED KINGDOM; MOD Systems Incorporated, Seattle, WA; PacketVideo Corporation, San Diego, CA; BACH Technology AS, Bergen, NORWAY; Sony Corporation of...

Rahul Siddharthan

Indian Academy of Sciences (India)

. Volume 4 Issue 2 February 1999 pp 66-76 Classroom. The Uncertainty Principle for Dummies · Rahul Siddharthan · More Details Fulltext PDF. Volume 4 Issue 3 March 1999 pp 8-15 General Article. Music, Mathematics and Bach - Layers of ...

Effects of Apis mellifera adansonii, L. 1758 (Apidae: Hymenoptera ...

African Journals Online (AJOL)

Effects of Apis mellifera adansonii, L. 1758 (Apidae: Hymenoptera) pollination on yields of Cucumeropsis mannii (Naudin) in Kisangani, Democratic Republic of Congo. Boniface Posho Ndola, Yves Brostaux, Guillaume Le Goff, Marie-Lucie Susini, Eric Haubruge, Frederic Francis, Bach Kim Nguyen ...

Scientists find link between allergic and autoimmune diseases in mouse study

Science.gov (United States)

Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, ce

Mark Raidpere portreefotod Kielis

Index Scriptorium Estoniae

1999-01-01

Kieli Linnagaleriis avatud 2. Ars Baltica fototriennaalil 'Can You Hear Me?' esindab Eestit Mark Raidpere seeriaga 'Portreed 1998'. Näituse Eesti-poolne kuraator Anu Liivak, kataloogiteksti kirjutas Anders Härm. Tuntumaid osalejaid triennaalil Wolfgang Tillmans

Baselist Californiasse ja sealt Tallinna = From Basel to Califonia and from there to Tallinn / Ivar Sakk

Index Scriptorium Estoniae

Sakk, Ivar, 1962-

2001-01-01

Ameerika iseõppinud disaineri David Carsoni, šveitsi tüpograafi Wolfgang Weingarti ja eesti disaineri ja graafiku Villu Järmuti loomingu kõrvutamine. Graafilise disaini areng Euroopas, nn. Baseli koolkond, "uus laine" (New Wave)

Baselist Californiasse ja sealt Tallinna / Ivar Sakk

Index Scriptorium Estoniae

Sakk, Ivar, 1962-

2011-01-01

Ameerika iseõppinud disaineri David Carsoni, šveitsi tüpograafi Wolfgang Weingarti ja eesti disaineri ja graafiku Villu Järmuti loomingu kõrvutamine. Graafilise disaini areng Euroopas, nn. Baseli koolkond, "uus laine" (New Wave)

Berlinale 2003 : "Lenin" - poeg lavastab ema jaoks Saksa DV edasikestmise / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2003-01-01

Festivalist, mis toimub loosungi all "Towards tolerance" ja võistluskava filmidest : briti režissööri Michael Winterbottomi "Siin maailmas", sakslase Wolfgang Beckeri absurdikomöödia "Jumalaga, Lenin!" ning Steven Soderberghi "Solaris"

BACHSCORE. A tool for evaluating efficiently and reliably the quality of large sets of protein structures

Science.gov (United States)

Sarti, E.; Zamuner, S.; Cossio, P.; Laio, A.; Seno, F.; Trovato, A.

2013-12-01

In protein structure prediction it is of crucial importance, especially at the refinement stage, to score efficiently large sets of models by selecting the ones that are closest to the native state. We here present a new computational tool, BACHSCORE, that allows its users to rank different structural models of the same protein according to their quality, evaluated by using the BACH++ (Bayesian Analysis Conformation Hunt) scoring function. The original BACH statistical potential was already shown to discriminate with very good reliability the protein native state in large sets of misfolded models of the same protein. BACH++ features a novel upgrade in the solvation potential of the scoring function, now computed by adapting the LCPO (Linear Combination of Pairwise Orbitals) algorithm. This change further enhances the already good performance of the scoring function. BACHSCORE can be accessed directly through the web server: bachserver.pd.infn.it. Catalogue identifier: AEQD_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEQD_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License version 3 No. of lines in distributed program, including test data, etc.: 130159 No. of bytes in distributed program, including test data, etc.: 24 687 455 Distribution format: tar.gz Programming language: C++. Computer: Any computer capable of running an executable produced by a g++ compiler (4.6.3 version). Operating system: Linux, Unix OS-es. RAM: 1 073 741 824 bytes Classification: 3. Nature of problem: Evaluate the quality of a protein structural model, taking into account the possible “a priori” knowledge of a reference primary sequence that may be different from the amino-acid sequence of the model; the native protein structure should be recognized as the best model. Solution method: The contact potential scores the occurrence of any given type of residue pair in 5 possible

Mind, matter, and Pauli

International Nuclear Information System (INIS)

Stapp, H.P.

1992-01-01

The role of subjective experience in physical theory is discussed, with particular attention to the later ideas of Wolfgang Pauli. These ideas appear to open the door to a unified framework for the development of science

Semiokapitalismus und imperiale Kontrollgesellschaft Zur Digitalisierung der Produktion am Beginn des 21. Jahrhunderts

Directory of Open Access Journals (Sweden)

Wolfgang Neurath

2014-12-01

Full Text Available Wolfgang Neurath analysiert angesichts des kybernetischen Semiokapitalismus und des durch ihn entstandenen "Kognitariats" in welcher Art und Weise digitale Produktions- und Wertschöpfungsprozesse am Beginn des 21. Jahrhunderts zur Kontrolle eingesetzt werden ...

Mind, matter, and Pauli

Energy Technology Data Exchange (ETDEWEB)

Stapp, H.P.

1992-09-10

The role of subjective experience in physical theory is discussed, with particular attention to the later ideas of Wolfgang Pauli. These ideas appear to open the door to a unified framework for the development of science.

Singularity-free static centrally symmetric solutions of some fourth order gravitational field equations

International Nuclear Information System (INIS)

Fiedler, B.; Schimming, R.

1983-01-01

The fourth order field equations proposed by TREDER with a linear combination of BACH's tensor and EINSTEIN's tensor on the left-hand side admit static centrally symmetric solutions which are analytical and non-flat in some neighborhood of the centre of symmetry. (author)

Resonance energy transfer from quinolinone modified polystyrene-block-poly(styrene-alt-maleic anhydride) copolymer to terbium(III) metal ions

Energy Technology Data Exchange (ETDEWEB)

Výprachtický, Drahomír, E-mail: vyprachticky@imc.cas.cz [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic); Mikeš, František [New York University Polytechnic School of Engineering, Polymer Research Institute, 6 MetroTech Center, Brooklyn, NY 11201 (United States); Lokaj, Jan; Pokorná, Veronika; Cimrová, Věra [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague 6 (Czech Republic)

2015-04-15

Polystyrene-block-poly(styrene-alt-maleic anhydride) was synthesized by nitroxide mediated radical polymerization and modified with 7-amino-4-methylquinolin-2(1H)-one (I) and methanol. The formed block polymer ligand contained a quinolinone fluorophore (Ω) and carboxyl (III) or sodium carboxylate (IV) binding sites. The ligand-to-metal resonance energy transfer (RET) and ligand binding properties of [III–Tb{sup 3+}] and [IV–Tb{sup 3+}] complexes were investigated by steady-state and time-resolved luminescence spectroscopy in tetrahydrofuran/methanol and/or tetrahydrofuran/deuterated methanol mixtures and compared with those of a low-molecular-weight model ligand, i.e. the sodium salt of N-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)succinamic acid (II). The long-lived emission intensities of Tb{sup 3+} at 490, 545, 585, and 620 nm corresponding to the {sup 5}D{sub 4}→{sup 7}F{sub 6}, {sup 5}D{sub 4}→{sup 7}F{sub 5}, {sup 5}D{sub 4}→{sup 7}F{sub 4}, and {sup 5}D{sub 4}→{sup 7}F{sub 3} transitions, respectively, were strongly increased by the addition of ligands in the order [II-Tb{sup 3+}]⪡[III-Tb{sup 3+}]<[IV-Tb{sup 3+}]. The efficiency of energy transfer (E) was evaluated from the emission intensity of the donor (Ω) in the presence or absence of the acceptor (Tb{sup 3+}) depending on the acceptor concentration and ligand neutralization. It was concluded that the macromolecular ligand structural properties (polymer coil and supramolecular structures, e.g. micelles) were responsible for the increase in RET. The time-resolved luminescence measurements revealed that the binding affinity of the ligands II, III, and IV increased in the order II

Weyl gravity as a gauge theory

Science.gov (United States)

Trujillo, Juan Teancum

In 1920, Rudolf Bach proposed an action based on the square of the Weyl tensor or CabcdCabcd where the Weyl tensor is an invariant under a scaling of the metric. A variation of the metric leads to the field equation known as the Bach equation. In this dissertation, the same action is analyzed, but as a conformal gauge theory. It is shown that this action is a result of a particular gauging of this group. By treating it as a gauge theory, it is natural to vary all of the gauge fields independently, rather than performing the usual fourth-order metric variation only. We show that solutions of the resulting vacuum field equations are all solutions to the vacuum Einstein equation, up to a conformal factor---a result consistent with local scale freedom. We also show how solutions for the gauge fields imply there is no gravitational self energy.

Ateena ühendas Eesti Euroopaga / Marianne Mikko

Index Scriptorium Estoniae

Mikko, Marianne, 1961-

2003-01-01

EL-i tippkohtumine Ateenas, EL-iga ühinemise lepingule allakirjutamise tseremooniast. President Arnold Rüütli kõnest. Kommenteerivad Austria kantsler Wolfgang Schüssel, Soome peaminister Paavo Lipponen, Läti peaminister Einars Repshe, Ungari ekspeaminister Viktor Orban

Tartu ülikool nimetas viis uut audoktorit

Index Scriptorium Estoniae

2016-01-01

Rahvusülikooli 97. aastapäeval pälvisid audoktori nimetuse prof-d Stefan Schreiner (usuteadus), Eberhard Klaus Wolfgang Winkler (keeleteadus), Christian Tomuschat (õigusteadus), Kauko K. Mäkinen (hambaarstiteadus), Markku Leskelä (loodus- ja täppisteadused)

[From Paul Flechsig to the Paul Flechsig Institute for Brain Research. Development of brain research at the Karl Marx University].

Science.gov (United States)

Leibnitz, L; Werner, L; Schober, W; Brauer, K

1977-04-01

A review is given on the development of the brain research institute of the Karl-Marx-University of Leipzig during the directorates of Paul Flechsig (1883-1920), Richard Arwed Pfeifer (1925-1957), and Wolfgang Wünscher (1957-1971).

A major safety overhaul

CERN Multimedia

2003-01-01

A redefined policy, a revamped safety course, an environmental project... the TIS (Technical Inspection and Safety) Division has begun a major safety overhaul. Its new head, Wolfgang Weingarten, explains to the Bulletin why and how this is happening.

miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

Directory of Open Access Journals (Sweden)

Graziella Cimino-Reale

2017-07-01

features (e.g. c-circle DNA and reduced expression levels of chromatin remodeler ATRX resembling an alternative lengthening of telomeres (ALT phenotype. Conclusions miR-380-5p interferes with TA in DMPM cells by targeting TEP1. Notably, in the long-term setting, miR-380-5p-mediated impairment of TA did not result in telomere attrition. Instead, a phenotype reminiscent of ALT emerged in DMPM cells as possible compensatory pathway that safeguards DMPM cell growth, an event that may be regarded as a potential resistance mechanism to anticancer therapies based on telomerase inhibitors.

A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.

Science.gov (United States)

Lee, Unjin; Frankenberger, Casey; Yun, Jieun; Bevilacqua, Elena; Caldas, Carlos; Chin, Suet-Feung; Rueda, Oscar M; Reinitz, John; Rosner, Marsha Rich

2013-01-01

Although triple negative breast cancers (TNBC) are the most aggressive subtype of breast cancer, they currently lack targeted therapies. Because this classification still includes a heterogeneous collection of tumors, new tools to classify TNBCs are urgently required in order to improve our prognostic capability for high risk patients and predict response to therapy. We previously defined a gene expression signature, RKIP Pathway Metastasis Signature (RPMS), based upon a metastasis-suppressive signaling pathway initiated by Raf Kinase Inhibitory Protein (RKIP). We have now generated a new BACH1 Pathway Metastasis gene signature (BPMS) that utilizes targets of the metastasis regulator BACH1. Specifically, we substituted experimentally validated target genes to generate a new BACH1 metagene, developed an approach to optimize patient tumor stratification, and reduced the number of signature genes to 30. The BPMS significantly and selectively stratified metastasis-free survival in basal-like and, in particular, TNBC patients. In addition, the BPMS further stratified patients identified as having a good or poor prognosis by other signatures including the Mammaprint® and Oncotype® clinical tests. The BPMS is thus complementary to existing signatures and is a prognostic tool for high risk ER-HER2- patients. We also demonstrate the potential clinical applicability of the BPMS as a single sample predictor. Together, these results reveal the potential of this pathway-based BPMS gene signature to identify high risk TNBC patients that can respond effectively to targeted therapy, and highlight BPMS genes as novel drug targets for therapeutic development.

A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.

Directory of Open Access Journals (Sweden)

Unjin Lee

Full Text Available Although triple negative breast cancers (TNBC are the most aggressive subtype of breast cancer, they currently lack targeted therapies. Because this classification still includes a heterogeneous collection of tumors, new tools to classify TNBCs are urgently required in order to improve our prognostic capability for high risk patients and predict response to therapy. We previously defined a gene expression signature, RKIP Pathway Metastasis Signature (RPMS, based upon a metastasis-suppressive signaling pathway initiated by Raf Kinase Inhibitory Protein (RKIP. We have now generated a new BACH1 Pathway Metastasis gene signature (BPMS that utilizes targets of the metastasis regulator BACH1. Specifically, we substituted experimentally validated target genes to generate a new BACH1 metagene, developed an approach to optimize patient tumor stratification, and reduced the number of signature genes to 30. The BPMS significantly and selectively stratified metastasis-free survival in basal-like and, in particular, TNBC patients. In addition, the BPMS further stratified patients identified as having a good or poor prognosis by other signatures including the Mammaprint® and Oncotype® clinical tests. The BPMS is thus complementary to existing signatures and is a prognostic tool for high risk ER-HER2- patients. We also demonstrate the potential clinical applicability of the BPMS as a single sample predictor. Together, these results reveal the potential of this pathway-based BPMS gene signature to identify high risk TNBC patients that can respond effectively to targeted therapy, and highlight BPMS genes as novel drug targets for therapeutic development.

Bach and Rock in the Music Classroom.

Science.gov (United States)

Ponick, F. S.

2000-01-01

Focuses on the use of popular music in music education, addressing issues such as defining popular music, approaches for using popular music in the classroom, and whether the National Standards for Music Education can be attained using popular music. Lists resources for teaching popular music. (CMK)

International Journal of Biological and Chemical Sciences - Vol 11 ...

African Journals Online (AJOL)

... L. 1758: Hymenoptera, Apidae) in three beekeeping sites of the Democratic Republic of Congo · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Boniface Posho Ndola, Paul Malumba, Bernard Wathelet, Eric Haubruge, Frederic Francis, Bach Kim Nguyen, 541-555.

Performance of human fecal anaerobe-associated PCR-based assays in a multi-laboratory method evaluation study

Science.gov (United States)

A number of PCR-based methods for detecting human fecal material in environmental waters have been developed over the past decade, but these methods have rarely received independent comparative testing. Here, we evaluated ten of these methods (BacH, BacHum-UCD, B. thetaiotaomic...

Getting the word out: Boosting science reporting in Africa and the ...

International Development Research Centre (IDRC) Digital Library (Canada)

2011-02-07

Feb 7, 2011 ... We sometimes have a different journalism 'culture'… because of how our ... adds, “Science journalists working in many developing countries haven't had ... Wolfgang Goede, a mentor and science news editor for Germany's ...

Turneri auhind määramisel / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2000-01-01

Londoni Tate Britainis avatud Turneri auhinna nominentide - Glenn Brown, Wolfgang Tillmans, Michael Raedecker, Tomoko Takahashi - näitusest ja struckistide "Tõelise Turneri auhinna näitusest" Pure Gallerys, kus eksponeeritakse rühmituse liikmete kunstimaailma jõustruktuure kritiseerivaid teoseid

Staff

Index Scriptorium Estoniae

2006-01-01

TÜ teadustöötajaist ja õppejõududest on 2/3 doktorikraadiga. TÜ rektor Jaak Aaviksoo ja teadusprprektor Ain Heinaru valiti Euroopa kõrghariduspoliitika juhtorganitesse. Sotsiaalteaduskonna prof. Wolfgang Drechsler sai Saksa-Eesti akadeemiliste suhete arendamise eest Saksamaa Liitvabariigi Teeneteristi

Identification of DNA-binding sites for the activator involved in late transcription of the temperate lactococcal phage TP901-1

DEFF Research Database (Denmark)

Pedersen, Margit; Kilstrup, Mogens; Hammer, Karin

2006-01-01

Alt, encoded by the lactococcal phage TP901-1, is needed for late transcription. We identify Alt as a DNA-binding protein, and footprint analysis shows that Alt binds to a region containing four imperfect direct repeats (ALT boxes) located -76 to -32 relative to the P-late transcriptional start...... site. The importance of the ALT boxes was confirmed by deletion of one or two ALT boxes and by introducing mutations in ALT boxes 1 and 4. Alt is proposed to act as a tetramer or higher multimer activating transcription of TP901-1 late genes by binding to the four ALT boxes, and bending of the DNA may...... be important for transcriptional activation of P-late. Furthermore, our results suggest that DNA replication may be required for late transcription in TP901-1. Additionally, we identify gp28 of the related lactococcal phage Tuc2009 as an activator and show that the activators required for late transcription...

Suurimad toetajad külas / Toivo Olvi

Index Scriptorium Estoniae

Olvi, Toivo

2003-01-01

11. VII külastasid Inju lastekodu mõisa ehitaja ja omaniku Hermann von Krause järeltulijad. Wolfgang ja Riccarda von Mecklenburg toetasid tänavu lastekodu renoveerimist 10000 euroga. Lühtri ostmiseks annetas raha Mati Hint. Lastekodu finantseerimisest

Muusikamaailm : "MaerzMusik" Berliinis. Rostropovitshi juubel algas. Wolfganf Rihm 50 / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Endine Saksa DV "Musik-Biennale Berlin" hakkab kandma uut nime "MaerzMusik. Festival für aktuelle Musik". 75aastaseks saav Mstislav Rostropovitsh tähistab oma juubelit mitmete kontsertidega. Lühidalt saksa helilooja Wolfgang Rihmist, kes sai hiljuti 50-aastaseks

AUTHOR INDEX

Indian Academy of Sciences (India)

CR). Engelmann Wolfgang (8) ... Gadani Deepak H (11) 1053 (CR). Ghosh Dipanjan (1) 47 (GA). Godbole Rohini (11) 1019 (GA) ... Natarajan Vasant (4) 301 (AIB); 322 (GA). Nath Biman (5) 428 (GA). Nath Triloki (2) 188 (CR). Nikolajek Mara (2) ...

Panofsky Agonisters: 1950 Loyalty Oath at Berkeley; Pief navigates the crisis

Energy Technology Data Exchange (ETDEWEB)

Jackson, John David

2008-08-14

In 1949-1951 the University of California was traumatized and seriously damaged by a Loyalty Oath controversy. Wolfgang K. H. Panofsky, a young and promising physics professor and researcher at Lawrence's Radiation Laboratory, was caught up in the turmoil.

Der immerwährende Kaiser. Der Plan für die "Provinzkapitel" in Braunau in dem sog. Dientzenhofer-Skizzenbuch

Czech Academy of Sciences Publication Activity Database

Štěrbová, Daniela; Patrný, M.

2014-01-01

Roč. 62, č. 3 (2014), s. 240-250 ISSN 0049-5123 R&D Projects: GA ČR GAP409/12/2568 Institutional support: RVO:68378033 Keywords : Broumov Monastery * site plan * Wolfgang Dientzenhofer Subject RIV: AL - Art, Architecture, Cultural Heritage

The Lessons of Counterpoint: Ernst’s Media Archaeology and Practical Archival Research

NARCIS (Netherlands)

Griffin, Ken

2015-01-01

abstractThe writings of the German scholar Wolfgang Ernst have become increasingly influential within media archaeology in recent years. His work adopts a strongly techno-centric approach and identifies archives as important study centres. Paradoxically, practical archival evidence is sometimes

Novel poly(triphenylamine-alt-fluorene) with asymmetric hexaphenylbenzene and pyrene moieties: synthesis, fluorescence, flexible near-infrared electrochromic devices and theoretical investigation

KAUST Repository

Wang, Po-I.

2016-01-13

© The Royal Society of Chemistry 2016. In this study, a new triphenylamine-alt-fluorene conjugated copolymer, HPBPYFL6, with hexaphenylbenzene (HPB) and pyrene as asymmetrical pendant groups was synthesized via Suzuki coupling polymerization. The conjugated polymer had a weight-average molecular weight of 5.8 × 104 g mol-1 with a polydispersity index of 2.5 characterized by gel permeation chromatography (GPC). HPBPYFL6 showed good solubility in common organic solvents such as NMP, THF, toluene and dichloromethane at 25°C. In addition, HPBPYFL6 possessed a high glass transition temperature of 260°C and a 10% weight-loss temperature of 503°C in nitrogen. HPBPYFL6 bearing a pyrene moiety had a solvatochromic fluorescence shift from a green to an orange emission as the polarity of the solvent increased. Cyclic voltammetry of HPBPYFL6 films cast onto indium-tin oxide-coated glass (ITO-glass) exhibited two oxidation redox couples at an E1/2 value of 0.82 and 1.17 V versus Ag/Ag+ in an acetonitrile solution. The HPBPYFL6 film on graphene-coated PET had an E1/2 value of 0.24 and 1.12 V. Conjugated polymer films exhibited reversible electrochromic behaviour with a colour change from pale yellow to deep blue upon electrochemical oxidation and high absorbance in the near-infrared (NIR) region. The switching and bleaching times were 5.16 s and 3.12 s for 1231 nm and were 3.30 s and 3.74 s for 1030 nm of HPBPYFL6 on ITO-glass. The strong NIR electrochromic absorbance of HPBPYFL6 was attributed to intervalence charge transfer by the incorporation of the HPB moiety. This phenomenon was confirmed by chemical oxidation as the oxidant contents increased in the solution state. Furthermore, the electrochromic mechanism was interpreted by DFT calculation and the simulated NIR electrochromic spectra of model compound HPBPYFL are in good agreement with the experimental data.

Theoretical Investigation on the Electronic and Optical Properties of Poly(fluorenevinylene Derivatives as Light-Emitting Materials

Directory of Open Access Journals (Sweden)

Thanisorn Yakhanthip

2011-01-01

Full Text Available Density functional theory (DFT and time-dependent DFT (TDDFT were employed to study ground-state properties, HOMO-LUMO gaps (ΔH-L, excitation energies (Eg, ionization potentials (IPs, and electron affinities (EA for PFV-alt-PDONV and PFV-alt-PDIH-PPV having different alternating groups. Excited-state properties were investigated using configuration interaction singles (CISs while fluorescence energies were calculated using TDDFT. The results show that PFV-alt-PDONV exhibits blue-shifted energies for both HOMO-LUMO gaps (ΔH-L and excitation energies (Eg compared with PFV-alt-PDIH-PPV. The predicted IP and EA clearly indicate that PFV-alt-PDIH-PPV has both easier hole creation and electron injection than that of PFV-alt-PDONV. The maximal absorption wavelengths of all polymers are strongly assigned to π→π∗ transition. The predicted radiative lifetimes of PFV-alt-PDONV and PFV-alt-PDIH-PPV for B3LYP/6-31G(d are 0.36 and 0.61 ns, respectively, indicating that PFV-alt-PDIH-PPV should have a better performance for long-time emission than that of PFV-alt-PDONV.

Discovering Structure in High-Dimensional Data Through Correlation Explanation

Science.gov (United States)

2014-12-08

transforming complex data into simpler, more meaningful forms goes under the rubric of representation learning [2] which shares many goals with...Zhivotovsky, and M.W. Feldman. Genetic structure of human populations. Science, 298(5602):2381–2385, 2002. [14] K. Bache and M. Lichman. UCI machine

Multisensory integration, sensory substitution and visual rehabilitation

DEFF Research Database (Denmark)

Proulx, Michael J; Ptito, Maurice; Amedi, Amir

2014-01-01

Sensory substitution has advanced remarkably over the past 35 years since first introduced to the scientific literature by Paul Bach-y-Rita. In this issue dedicated to his memory, we describe a collection of reviews that assess the current state of neuroscience research on sensory substitution...

Melodic cues for metre

NARCIS (Netherlands)

Vos, P G; van Dijk, A; Schomaker, Lambertus

1994-01-01

A method of time-series analysis and a time-beating experiment were used to test the structural and perceptual validity of notated metre. Autocorrelation applied to the flow of melodic intervals between notes from thirty fragments of compositions for solo instruments by J S Bach strongly supported

Cross-Cultural Issues in Parent Involvement.

Science.gov (United States)

Tran, Bach-Tuyet Pham; And Others

Four papers address cultural issues related to the involvement of limited-English-proficient parents in public schools in the United States. "Cultural Issues in Indochinese Parent Involvement" (Bach-Tuyet (Pham) Tran) outlines the linguistic, social, and practical barriers to Indochinese immigrant parent involvement and makes suggestions for…

Population dynamics of Lemniscomys rosalia (Muridae: Rodentia) in ...

African Journals Online (AJOL)

Numerous studies have reported increases in rodent populations following good rainfall (Nel 1978; Perrin & Swanepoel 1987; Bronner, Rau- ten bach & Meester 1988). This relationship is thought to be an indirect one where increased rainfall acts to increase cover and food supply. thus enabling rodents to reproduce (Neal.

Ilmus uus CD Arvo Pärdi muusikaga, esitajaks eestlased

Index Scriptorium Estoniae

2004-01-01

heliplaadi "Pro & contra" andis välja Virgin Classics, Eesti Riiklik Sümfooniaorkester Paavo Järvi dirigeerimisel esitab seal järgmised A. Pärdi teosed - "Meie aed", 1. ja 2. sümfoonia, "Pro & contra", "Kollaaž teemal B-A-C-H" ja "Perpetum mobile"

The complete nucleotide sequence of Alternanthera mosaic virus infecting Portulaca grandiflora represents a new strain distinct from phlox isolates.

Science.gov (United States)

Ivanov, Peter A; Mukhamedzhanova, Anna A; Smirnov, Alexander A; Rodionova, Nina P; Karpova, Olga V; Atabekov, Joseph G

2011-04-01

A southeastern European isolate of Alternanthera mosaic virus (AltMV-MU) of the genus Potexvirus (family Flexiviridae) was purified from the ornamental plant Portulaca grandiflora. The complete nucleotide sequence (6606 nucleotides) of AltMV-MU genomic RNA was defined. The AltMV-MU genome is different from those of all isolates described earlier and is most closely related to genomes of partly sequenced portulaca isolates AltMV-Po (America) and AltMV-It (Italy). Phylogenetic analysis supports the view that AltMV-MU belongs to a new "portulaca" genotype distinguishable from the "phlox" genotype.

The BRCT domain is a phospho-protein binding domain.

Science.gov (United States)

Yu, Xiaochun; Chini, Claudia Christiano Silva; He, Miao; Mer, Georges; Chen, Junjie

2003-10-24

The carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein is an evolutionarily conserved module that exists in a large number of proteins from prokaryotes to eukaryotes. Although most BRCT domain-containing proteins participate in DNA-damage checkpoint or DNA-repair pathways, or both, the function of the BRCT domain is not fully understood. We show that the BRCA1 BRCT domain directly interacts with phosphorylated BRCA1-Associated Carboxyl-terminal Helicase (BACH1). This specific interaction between BRCA1 and phosphorylated BACH1 is cell cycle regulated and is required for DNA damage-induced checkpoint control during the transition from G2 to M phase of the cell cycle. Further, we show that two other BRCT domains interact with their respective physiological partners in a phosphorylation-dependent manner. Thirteen additional BRCT domains also preferentially bind phospho-peptides rather than nonphosphorylated control peptides. These data imply that the BRCT domain is a phospho-protein binding domain involved in cell cycle control.

Elongational viscosity of monodisperse and bidisperse polystyrene melts

DEFF Research Database (Denmark)

Nielsen, Jens Kromann; Rasmussen, Henrik Koblitz; Hassager, Ole

2005-01-01

The startup and steady uniaxial elongational viscosity have been measured for two monodisperse polystyrene melts with molecular weights of 52 kg/mole (PS52K) and 103 kg/mole (PS103K), and for three bidisperse polystyrene melts. The bidisperse melts consist of PS103K or PS52K and a monodisperse...... (closed loop proportional regulator) using the laser in such a way that the stretch rate at the neck is kept constant. The rheometer has been described in more detail in (A. Bach, H.K. Rasmussen and O. Hassager, Journal of Rheology, 47 (2003) 429). PS390K show a decrease in the steady viscosity as a power......-law function of the elongational rate (A. Bach, K. Almdal, H.K. Rasmussen and O. Hassager, Macromolecules 36 (2003) 5174). PS52K and PS103K show that the steady viscosity has a maximum that is respectively 100% and 50% above 3 times the zero-shear-rate viscosity. The bidisperse melts show a significant...

Distribution patterns of Recent planktonic foraminifera in surface sediments of the western continental margin of India

Digital Repository Service at National Institute of Oceanography (India)

Naidu, P.D.

. Acknowledgements I am thankful to B.N. Desai, Director, National Institute of Oceanography and R.R. Nair for their encouragement. My sincere thanks go to James L. Cullen, Wolfgang H. Berger and William F. Ruddi- man for their valuable suggestions on an earlier...

Berlinskaja stena i Rimskije kanikulõ / Jevgeni Levik

Index Scriptorium Estoniae

Levik, Jevgeni

2003-01-01

Mängufilmid "Hüvasti, Lenin!" ("Good Bye, Lenin!") : režissöör Wolfgang Becker : Saksamaa 2003 ja "Lizzie McGuire - koolitüdrukust popstaariks" ("The Lizzie McGuire Movie") : režissöör Jim Fall : Ameerika Ühendriigid 2003

Bagatellid : maailm / Mailis Põld

Index Scriptorium Estoniae

Põld, Mailis

2006-01-01

Muusikasõnumeid mujalt maailmast: Matusemuusikust ooperidiiva Erika Sunnegardh. Lionel Bringuier - noor talent dirigentide seas. Riccardo Muti naudib vabakutselise staatust. Mstislav Rostropovitsh lõpetab sooloesinemised. Lahkumisest on teatanud maestro Wolfgang Sawallisch. Arturo Benedetti Michelangeli preemia läheb sel aastal rumeenlasele pianist Radu Lupule.

Bagatellid : Maailm / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2010-01-01

Muusikasõnumeid maailmast: Müncheni Filharmoonikute peadirigendiks saab Lorin Maazel. Metropolitan Opera sai eraisikult kingiks 30 miljonit USA dollarit. Dirigent Michael Gielen võitis Ernst von Siemensi preemia. Suri Bayreuthi ooperifestivali kauaaegne juht Wolfgang Wagner. Viini Filharmoonikute kontsertmeistriks sai naine - Albena Danailova

Goethe's "Delicate Empiricism": Assessing Its Value for Australian Ecologists

Science.gov (United States)

Bradley, Melanie

2011-01-01

Johann Wolfgang von Goethe, recognised as a seminal German polymath, developed a unique approach for investigating nature, termed "delicate empiricism". Goethe's approach uses empathy, imagination and intuition to promote a participatory engagement with the world. It goes beyond the dualistic-rationalism that defines…

Jung und Alt im Dialog

Directory of Open Access Journals (Sweden)

Caroline Baetge

2012-04-01

Full Text Available Rezension zu: Kupser, Thomas, und Ida Pöttinger, Hrsg. 2011. Mediale Brücken: Generationen im Dialog durch aktive Medienarbeit. Gesellschaft - Altern - Medien 3. München: kopaed.

Alt av kærleika

DEFF Research Database (Denmark)

Joensen, Dagny

I begyndelse af 1960’erne blev der bygget en Nato-radarstation på Færøerne, og den var de første år bemandet med amerikanske eksperter. Flere færøske kvinder blev gift med disse amerikanere og fulgte med dem tilbage til USA. I denne bog interviewes en række af disse kvinder...

United States Air Force Academy: A Bibliography 2011-2015

Science.gov (United States)

2016-11-23

21 VI. ATHLETIC DEPARTMENT AND SPORTS - - - - - - - - - - - - - - - - - - - - 23 VII. BASIC CADET...Mendoza, Monica. "Mayor Bach Unveils Plan to Help Attract Tourism ." The Gazette 2 July 2013: A1, A6. Print. 183. ---. " Colorado Springs to Seek...22 PART VI ATHLETIC DEPARTMENT AND SPORTS BOOKS, DOCUMENTS AND REPORT

From the editors

NARCIS (Netherlands)

NN,

2001-01-01

Hofstadter’s Law: Things always take longer than you think, even when you take into account Hofstadter’s Law. [D. Hofstadter, Gödel, Escher, Bach: an eternal golden braid (1980) 152]. This certainly applies to the forthcoming issues of the Flora Malesiana. According to its editors the bottleneck

De Eeuwwende 1700 (dl.3): de Kunsten

NARCIS (Netherlands)

Klukhuhn, A.; Rasch, R.A.

1991-01-01

Toekomstige geschiedschrijving zal ongetwijfeld uitwijzen dat de eeuwwende 1700 de meest onderschatte eeuwwende van de laatste vijfhonderd jaar is. Corelli dateerde zijn Opus 5 bewust op 1 januari 1700 om het belang aan te geven dat hij aan de nieuwe eeuw hechtte. Met Bach, Händel en Scarlatti lag

Uudised : Talvemuusika Otepääl. Soome-Eesti Barokkorkester. Müstiline ühinemine. Bachi kogutud lautomuusika CD / Igor Garshnek

Index Scriptorium Estoniae

Garšnek, Igor, 1958-

1999-01-01

26.-29. dets. toimuvast III Otepää talvemuusikafestivalist. 5. jaan. 2000.a. toimuvast Soome-Eesti Barokkorkestri 10. aastapäevale pühendatud kontserdist, orkestri ajaloost, tegevusest. T. Saviaugu ja T. Petersoni CD-plaadist "Mystical Uniting". H. Mätliku topelt-CDst "J.S. Bach - Complete Lute Works"

Mathematics. [SITE 2002 Section].

Science.gov (United States)

Connell, Michael L., Ed.; Lowery, Norene Vail, Ed.; Harnisch, Delwyn L., Ed.

This document contains the following papers on mathematics from the SITE (Society for Information Technology & Teacher Education) 2002 conference: (1) "Teachers' Learning of Mathematics in the Presence of Technology: Participatory Cognitive Apprenticeship" (Mara Alagic); (2) "A Fractal Is a Pattern in Your Neighborhood" (Craig N. Bach); (3)…

Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons

Directory of Open Access Journals (Sweden)

Guoyang Huang

2016-12-01

Full Text Available Spinal cord injury (SCI is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock protein (HSP 32 induction. In this study, underlying molecular mechanisms were further investigated. The results showed that a single exposure to HBO significantly increased intracellular levels of reactive oxygen species (ROS and nitric oxide (NO and activated MEK1/2, ERK1/2, p38 MAPK, CREB, Bach1 and Nrf2. The induction of HSP32 by HBO was significantly reversed by pretreatment neurons with ROS scavenger N-Acetyl-L-cysteine, p38 MAPK inhibitor or Nrf2 gene knockdown, enhanced by MEK1/2 inhibitors or gene knockdown but not by ERK1/2 inhibitor. CREB knockdown did not change the expression of HSP32 induced by HBO. N-Acetyl-L-cysteine significantly inhibited the activation of MEK1/2, ERK1/2, p38 MAPK, and Nrf2. Activation of Nrf2 was significantly inhibited by p38 MAPK inhibitor and the nuclear export of Bach1 was significantly enhanced by MEK1/2 inhibitor. The results demonstrated that HBO induces HSP32 expression through a ROS/p38 MAPK/Nrf2 pathway and the MEK1/2/Bach1 pathway contributes to negative regulation in the process. More importantly, as we know, this is the first study to delineate that ERK1/2 is not the only physiological substrates of MEK1/2.

Prikljutshenija "Poseidona"

Index Scriptorium Estoniae

2006-01-01

Katastroofifilm "Poseidon" : režissöör Wolfgang Petersen : operaator John Seale : Ameerika Ühendriigid 2006. Filmi eelkäijaks on 1972.a. Paul Gallico romaani järgi vändatud film "The Poseidon Adventure", mida peetakse kaasaegse katastroofifilmi eelkäijaks

78 FR 34160 - Proposed Collection; Comment Request; Office of Financial Stability

Science.gov (United States)

2013-06-06

... Purchase Program (CPP) under which the Department has purchased qualifying capital in U.S. banking... Treasury has invested through the CPP. Consequently, the Treasury is seeking responses from banking..., maintenance, and purchase of services to provide information. Dated: June 3, 2013. Dawn D. Wolfgang, Treasury...

Languages at Work in Europe

DEFF Research Database (Denmark)

Foreign language competences are vital not only for the individual European citizen, but in a more encompassing perspective, for mobility, socio-economic development and the competitiveness of Europe in a global world. - For more than a decade, Professor Wolfgang Mackiewicz of the Freie Universit...

Orákulum bez pozounů není od Mozarta

Czech Academy of Sciences Publication Activity Database

Jonášová, Milada; Volek, T.

2016-01-01

Roč. 23, č. 4 (2016), s. 27-29 ISSN 1210-8081 R&D Projects: GA ČR GAP409/12/2563 Institutional support: RVO:68378076 Keywords : Wolfgang Amadeus Mozart * Idomeneo * Jan Křtitel Kuchař * Prague 1792 Subject RIV: AL - Art, Architecture, Cultural Heritage

Muusikamaailm : Weimari Riigikapell 400. Korngoldi mälestuspäevad Brnos. Ooperietendus taas Indias. Uusooperid laval Euroopas / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Weimari Riigikapell tähistab oma 400. aastapäeva. Brnos tähistatakse mitmete muusikasündmustega helilooja Erich Wolfgang Korngoldi mälestuspäevasid. New Delhi Siri Forti auditooriumis kõlab üle hulga aja ooper. Euroopa eri linnades toimuvatest ooperite uusalvastustest

Saksa vaim Kunstihoones

Index Scriptorium Estoniae

2001-01-01

Fotokunsti väljapanek "Ajastu vaim. Saksa moefotod 1945-1995". Kuraator F. C Gundlach. Esindatud kunstnikud Helmut Newton, Wolfgang Tillmans, Jürgen Teller, Charlotte Rohrbach, Norbert Leonard, Willy Maywald, Regi Relang, Hubs Flöter, Herbert Tobias, Rico Puhlmann, Will McBride, Charlotte March.

Still controversial

Energy Technology Data Exchange (ETDEWEB)

Anon.

1986-10-15

It is some sixty years since the existence of the neutrino was controversially postulated by the controversial Wolfgang Pauli. Today, the neutrino remains controversial. At the Berkeley Conference, summarizer Steve Weinberg kept the spotlight on these enigmatic particles during a considerable portion of his talk.

Still controversial

International Nuclear Information System (INIS)

Anon.

1986-01-01

It is some sixty years since the existence of the neutrino was controversially postulated by the controversial Wolfgang Pauli. Today, the neutrino remains controversial. At the Berkeley Conference, summarizer Steve Weinberg kept the spotlight on these enigmatic particles during a considerable portion of his talk

Borchert's "Lesebuchgeschichten": History and Culture through Literature

Science.gov (United States)

Stark, James L.

1977-01-01

Wolfgang Borchert's "Lesebuchgeschichten" present a summary view of German society before and after World War II and could easily serve as the focal point for a presentation of the Third Reich in a course on German culture and history. The works are described here. (CHK)

Problematising development in sustainability: epistemic justice ...

African Journals Online (AJOL)

The paper draws on the work of Wolfgang Sachs (1999) who asserts that the notion of sustainability has been consumed by development, presenting a view of sustainability which challenges the current and dominant economically driven hegemonic development discourse in which sustainability has become embedded.

Some Intermediate-Level Violin Concertos.

Science.gov (United States)

Abramson, Michael

1997-01-01

Contends that many violin students attempt difficult concertos before they are technically or musically prepared. Identifies a variety of concertos at the intermediate and advanced intermediate-level for students to study and master before attempting the advanced works by Bach and Mozart. Includes concertos by Vivaldi, Leclair, Viotti, Haydn,…

Tense and Aspect in English

DEFF Research Database (Denmark)

Davidsen-Nielsen, Niels

2013-01-01

In the 1990's the author cooperated with Carl Bache on a grammar of English. It turned out that the views they had previously arrived at individually on tense and aspect could be combined by operating with a fused system involving four ordered choices resulting in sixteen tense-aspect forms...

Early Top-Down Influences on Bistable Perception Revealed by Event-Related Potentials

Science.gov (United States)

Pitts, Michael A.; Gavin, William J.; Nerger, Janice L.

2008-01-01

A longstanding debate exists in the literature concerning bottom-up vs. top-down influences on bistable perception. Recently, a technique has been developed to measure early changes in brain activity (via ERPs) related to perceptual reversals (Kornmeier & Bach, 2004). An ERP component, the reversal negativity (RN) has been identified, and is…

A Micro-Platinum Wire Biosensor for Fast and Selective Detection of Alanine Aminotransferase

Directory of Open Access Journals (Sweden)

Tran Nguyen Thanh Thuy

2016-05-01

Full Text Available In this study, a miniaturized biosensor based on permselective polymer layers (overoxidized polypyrrole (Ppy and Nafion® modified and enzyme (glutamate oxidase (GlutOx immobilized micro-platinum wire electrode for the detection of alanine aminotransferase (ALT was fabricated. The proposed ALT biosensor was measured electrochemically by constant potential amperometry at +0.7 V vs. Ag/AgCl. The ALT biosensor provides fast response time (~5 s and superior selectivity towards ALT against both negatively and positively charged species (e.g., ascorbic acid (AA and dopamine (DA, respectively. The detection range of the ALT biosensor is found to be 10–900 U/L which covers the range of normal ALT levels presented in the serum and the detection limit and sensitivity are found to be 8.48 U/L and 0.059 nA/(U/L·mm2 (N = 10, respectively. We also found that one-day storage of the ALT biosensor at −20 °C right after the sensor being fabricated can enhance the sensor sensitivity (1.74 times higher than that of the sensor stored at 4 °C. The ALT biosensor is stable after eight weeks of storage at −20 °C. The sensor was tested in spiked ALT samples (ALT activities: 20, 200, 400, and 900 U/L and reasonable recoveries (70%~107% were obtained.

Alcohol intake, alcohol dehydrogenase genotypes, and liver damage and disease in the Danish general population

DEFF Research Database (Denmark)

Tolstrup, J.S.; Gronbaek, M.; Tybjaerg-Hansen, A.

2009-01-01

the Copenhagen City Heart Study. Biochemical tests for the detection of liver damage were specific for alanine aminotransferase (ALT), aspartate aminotransferase (AST)-to-ALT ratio (AST/ALT), gamma-glutamyl transpeptidase (gamma-GT), albumin, bilirubin, alkaline phosphatase, coagulation factors, and erythrocyte...... volume. RESULTS: Increasing alcohol intake was associated with increasing erythrocyte volume, AST/ALT, and levels of ALT, gamma-GT, albumin, bilirubin, coagulation factors, and with decreasing levels of alkaline phosphatase. Multifactorially adjusted hazard ratios for alcoholic liver disease overall were...

Bacillus spp. produce antibacterial activities against lactic acid bacteria that contaminate fuel ethanol plants.

Science.gov (United States)

Manitchotpisit, Pennapa; Bischoff, Kenneth M; Price, Neil P J; Leathers, Timothy D

2013-05-01

Lactic acid bacteria (LAB) frequently contaminate commercial fuel ethanol fermentations, reducing yields and decreasing profitability of biofuel production. Microorganisms from environmental sources in different geographic regions of Thailand were tested for antibacterial activity against LAB. Four bacterial strains, designated as ALT3A, ALT3B, ALT17, and MR1, produced inhibitory effects on growth of LAB. Sequencing of rRNA identified these strains as species of Bacillus subtilis (ALT3A and ALT3B) and B. cereus (ALT17 and MR1). Cell mass from colonies and agar samples from inhibition zones were analyzed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. The spectra of ALT3A and ALT3B showed a strong signal at m/z 1,060, similar in mass to the surfactin family of antimicrobial lipopeptides. ALT3A and ALT3B were analyzed by zymogram analysis using SDS-PAGE gels placed on agar plates inoculated with LAB. Cell lysates possessed an inhibitory protein of less than 10 kDa, consistent with the production of an antibacterial lipopeptide. Mass spectra of ALT17 and MR1 had notable signals at m/z 908 and 930 in the whole cell extracts and at m/z 687 in agar, but these masses do not correlate with those of previously reported antibacterial lipopeptides, and no antibacterial activity was detected by zymogram. The antibacterial activities produced by these strains may have application in the fuel ethanol industry as an alternative to antibiotics for prevention and control of bacterial contamination.

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

... India; Division of Physics, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan; Advanced Science Research Center, Japan Atomic Energy Research Institute, Tokai, Ibaraki 319-11, Japan; Institut für Theoretische Physik, Johann Wolfgang Goethe-Universität, Robert-Mayer-Str. 10, 60325 Frankfurt ...

Remembering Pauli

CERN Multimedia

2002-01-01

The annual meeting of the Pauli Committee on 30 August will be enlivened this year by a celebration to mark the publication of : No Time to be Brief - A scientific biography of Wolfgang Pauli, by Charles P. Enz, Professor Emeritus of the University of Geneva.  

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... interactions, leading to the supramolecular organisation of the rings into a spiral-like of chain. Volume 119 Issue 3 May 2007 pp 243-252. Synthesis, spectroscopy and supramolecular structures of two magnesium 4-nitrobenzoate complexes · Bikshandarkoil R Srinivasan Jyoti V Sawant Christian Näther Wolfgang Bensch.

Mozart and smallpox

NARCIS (Netherlands)

Zegers, Richard H. C.

2007-01-01

In 1767 at 11 years of age, composer Wolfgang Amadeus Mozart contracted smallpox, allegedly causing him temporary blindness. Although now eradicated, smallpox in those days had a high mortality rate, and the history of classical music would have been very different if Mozart had become permanently

Initiative within the Philosophy of Auftragstaktik Determining Factors of the Understanding of Initiative in the German Army 1806-1955

Science.gov (United States)

2013-12-13

our free democratic basic order. The principles of Innere Führung are based on ethical, legal, political and social foundations and meet military...Minneapolis, MN: Zenith Press, 2009. Schneiderhan, Wolfgang. “Innere Führung ein hoher Anspruch an die Praxis, Rede an der Führungsakademie der

Speeding the traffic on grids

CERN Multimedia

Port, O

2002-01-01

CERN is one of a number of organizations looking at ways to to accelerate grid computing. CERN researcher Wolfgang Hoschek said new software will soon scan all the available computers on the Web and find the most efficient combination to solve a particular problem (1/3 page).

Lavateksti autorit otsimas : subtekstid ja subteosed lavastuse metatekstis / Talvo Pabut

Index Scriptorium Estoniae

Pabut, Talvo

2006-01-01

Kirjutis on ajendatud Wolfgang Iseri teaduslikust esseest "Lugemine. Fenomenoloogiline lähenemisviis" (Iser 1990). Püütakse teoreetiliselt analüüsida Iseri essees välja toodud fenomenoloogilise lähenemisviisi kasutamise võimalikkust või võimatust nüüdisaegse lavastajateatri lavateksti vaatlemisel

There is also an anti-nuclear movement in the USSR

International Nuclear Information System (INIS)

Anon.

1980-01-01

Wolfgang Rieger, who works on 'bild der wissenschaft' talked to the Soviet researcher, now living in London, who was deprived of this citizenship years ago, on the Soviet scientists' and technologists' working conditions, the areas on which they concentrate and how they see themselves. (orig.) [de

Equality in Language Learning. Proceedings of the Nordic Conference of Applied Linguistics, (5th, Jyvaskyla, Finland, June 4-7, 1987). AFinLA Series No. 45.

Science.gov (United States)

Sajavaara, Kari, Ed.

Papers presented at the conference on applied linguistics include the following: "Speaking of Grammars: Is Big Beautiful?" (Jan Svartvik); "A Sociosemiotic View of the Grasp of Language at Reality: The Lexical Field 'Aesthetic Judgment'" (Wolfgang Kuhlwein); "Language as a Target and Instrument of the Educational Process…

Goethe's Phenomenological Optics: The Point Where Language Ends and Experience Begins in Science.

Science.gov (United States)

Junker, Kirk

This paper explores whether phenomenology, in general, and the case of Johann Wolfgang von Goethe's phenomenological optics in particular, provides a case and a location for "minimal realism," located between the extreme positions of absolute scientific realists and "radical rhetoricians." The paper begins with a description of…

Environmental Information Systems. Integrative data management - Examples from the environmental monitoring; Umweltinformationssysteme. Integratives Datenmanagement - Beispiele aus der Umweltbeobachtung

Energy Technology Data Exchange (ETDEWEB)

Knetsch, Gerlinde; Jessen, Karin (comps.) [Umweltbundesamt, Dessau-Rosslau (Germany). Fachgebiet IV 2.1 Informationssysteme Chemikaliensicherheit

2010-02-15

Within the workshop ''Environmental databases / Environmental Information Systems'' of the German Federal Environment Agency (Dessau-Rosslau, Federal Republic of Germany) at 4th to 5th May, 2009, in Hof (Federal Republic of Germany), the following lectures were held: (1) The German Environmental Specimen Base in the Internet (Maria Ruether); (2) REACH IT tools and workflows for the European implementation of chemicals (Gerlinde Knetsch); (3) Design of a European portal for soil information in the scope of the eContentplus project GS soil as a component for SEIS based on the PortaIU {sup registered} technology (Martin Klenke, Stefanie Konstantinidis, Fred Kruse); (4) Introduction of SOS services for the exchange and presentation of numeric data in PortalU {sup registered} (Carsten Heidmann, Wassili Kazakos, Martin Klenke, Siegbert Kunz); (5) Internet portals of waste management in Schleswig-Holstein (Friedhelm Hosenfeld, Wolfgang Thiel, Johannes Bublitz); (6) FIS waters - an international specialized and information technological cooperation (Wolfgang Ballin).

Wind power for the world international reviews and developments

CERN Document Server

Maegaard, Preben; Palz, Wolfgang

2013-01-01

Introduction, Preben MaegaardAccelerated Global Expansion of the Renewable Energy Sector: the Example of Wind Energy, Preben MaegaardWind Power Development in the European Union, Wolfgang PalzWind Energy to the rescue of mankind from the menace of the Fossil Fuel burning hazards, Anil KaneBlack or Green Wind Power, Frede HvelplundWind Energy Development in China, He DexinNon-grid-connected Wind Power and Offshore "Three Georges of Wind Power" in China, Gu WeidongWind Power in Japan: Past, Present, and Future Prospect, Izumi UshiyamaWind Power Development in India, Jami HossainChallenges and Opportunities for Energy Paradigm Shifting in Ontario, Canada, Jose EtcheverryWind Power in Cuba's Energy Revolution, Conrado Moreno FigueredoWind Power in Argentina, Erico SpinadelThe Emergence of Wind Power in Brazil, Everaldo FeitosaWind Energy in Chile, Arturo KunstmannWind Power in Austria, Wolfgang HeinThe History of Wind Power in France, Jean-Louis BalHistory, State-of-the Art and Future of Wind Energy in France, Ma...

EU Commissioner visits CERN

CERN Multimedia

2005-01-01

European Commissioner Viviane Reding in front of one of the computers showing how the Grid works and, from left to right, Robert Aymar, CERN's Director-General, Wolfgang von Rüden, Head of the Information Technology Department, and Bob Jones, the newly appointed director of the EGEE project since 1st November. Viviane Reding, European Commissioner for Information Society and Media, visited CERN on 28 October. Accompanied throughout by CERN's Director-General, Robert Aymar, and the Head of the Information Technology Department, Wolfgang von Rüden, the Commissioner visited the ATLAS cavern before going on to the Information Technology Department, where she was given a complete overview of CERN's activities in the strategic field of Grid computing. Viviane Reding's visit coincided with the end of the EGEE (Enabling Grids for E-sciencE) conference, which took place in Pisa in Italy. Co-ordinated by CERN and funded by the European Commission, the EGEE project aims to set up a worldwide grid infrastructure for sc...

Adding Search as a first-class citizen to Hadoop

CERN Multimedia

CERN. Geneva

2014-01-01

Apache Hadoop is enabling organizations to collect larger, more varied data - but after it's collected how will it be found? Your users expect to be able to search for information using simple text based queries -- regardless of data location, size, and complexity. How do they quickly find information that's just been created, or been stored for months or even years? Cloudera Search Senior Software Engineer Wolfgang Hoschek will present a solution to this problem; what architecture is necessary to search HDFS and HBase? How was Apache Solr, Lucene, Flume and MapReduce integrated to allow for Near Real Time and Batch indexing of data? What are the solved problems and what's still to come? Join us for an exciting discussion on this new technology. About the speaker Wolfgang Hoschek is a Software Engineer at Cloudera working on the Hadoop Platform and Cloudera Search team. He is a committer on the Apache Flume and Apache Lucene/Solr projects, a committer on the Kite project, a committer...

Standing together in troubled times unpublished letters by Pauli, Einstein, Franck and others

CERN Document Server

2017-01-01

This captivating book is a story of the friendship between a genius physicist Wolfgang Pauli and Charlotte Houtermans whose career in physics was not as glamorous. They met in the late 1920s in Germany, at the very onset of the quantum era and personally knew all the major players in the emergent quantum world that was very much part of central Europe: Germany, Austria, Hungary, Denmark and Switzerland. And Charlotte was a student at Göttingen that was right at the heart.Caught between two evils — Soviet Communism and German National Socialism — she would have probably perished if it were not for the brotherhood of physicists: Niels Bohr, Wolfgang Pauli, Albert Einstein, James Franck, Max Born, Robert Oppenheimer and many other noted scientists who tried to save friends and colleagues (either leftist sympathizers or Jews) who were in mortal danger of being entrapped in a simmering pre-WWII Europe.Using newly discovered documents from the Houtermans family archive: twenty three Pauli's letters to Charlott...

Üzüm Çekirdeği Tozu ve Peynir Altı Suyu Tozunun Tavuk Nugget Kalitesi Üzerine Etkileri

Directory of Open Access Journals (Sweden)

Ece Cagdas

2015-02-01

Full Text Available Bu çalışma kapsamında; buğday unu, mısır unu, tuz ve kabartma ajanı ile hazırlanan basit kaplama hamuruna değişik oranlarda üzüm çekirdeği tozu (GSP eklenerek kaplanan ve peynir altı suyu tozu çözeltisine (WPS daldırılarak kaplanan tavuk eti parçalarının ön kızartma işleminden sonra nem, protein, yağ ve yüzeyde yapışma miktarları belirlenmiştir. Bunların yanı sıra, doku, taramalı elektron mikroskobu (SEM ve tiyobarbitürik asit (TBA analizleri yapılmıştır. Yapılan çalışma sonucunda GSP miktarı arttıkça nem (%66.20±0.71 – 68.22±0.38, protein (%16.16±1.36 – 19.73±1.40 ve yüzeyde yapışma miktarı (%26.27±0.43 – 36.13±0.71 artış gösterirken yağ miktarında (%8.18±0.17 – 4.78±0.54 azalış meydana gelmiştir. En düşük yağ miktarları WPS’ye daldırılarak hazırlanan örneklerde bulunmuştur. Uygulama yapılan örneklerde ön kızartma işleminden sonra da antioksidan aktivite gözlenmiş ve uygulama yapılan tüm örneklerin TBA değerleri (23.30±1.61 – 27.17±1.12 mg MDA/kg kontrol ile karşılaştırıldığında daha düşük seviyelerde olsa da önemli bir fark belirlenmemiştir (P>0.05. Elde edilen sonuçlara göre kaplama harcı malzemesi olarak GSP kullanımı ve WPS’ye daldırma işlemi kaplama harcının kalitesinin geliştirilmesinde bir potansiyele sahiptir.

Current distribution and ac susceptibility response of a thin superconducting disc in an axial field: a theoretical approach

Science.gov (United States)

Aruna, S. A.; Zhang, P.; Lin, F. Y.; Ding, S. Y.; Yao, X. X.

2000-04-01

Within the framework of the thermally activated process of the flux line or flux line bundles, and by time integration of the 1D equation of motion of the circulating current density icons/Journals/Common/vecJ" ALT="vecJ" ALIGN="TOP"/> (icons/Journals/Common/rho" ALT="rho" ALIGN="TOP"/> ,t ), which is suitable for thin superconducting films (R >>d ,icons/Journals/Common/le" ALT="le" ALIGN="TOP"/> icons/Journals/Common/lambda" ALT="lambda" ALIGN="TOP"/> ), we present numerical calculations of the current profiles, magnetization hysteresis loops and ac susceptibility icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> n = icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´n +iicons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´´n for n = 1, 3 and 5 of a thin disc immersed in an axial time-dependent external magnetic field Ba (t ) = Bdc +Bac cos(2icons/Journals/Common/pi" ALT="pi" ALIGN="TOP"/> icons/Journals/Common/nu" ALT="nu" ALIGN="TOP"/> t ). Our calculated results are compared with those of the critical state model (CSM) and found to prove the approximate validity of the CSM below the irreversibility field. The differences between our computed results and those of the CSM are also discussed.

Fifth and Sixth Grade Students' Deficiencies on Word Problem Solving and Failures in the Problem Solving Process [Beşinci ve Altıncı Sınıf Öğrencilerinin Sözel Problemleri Çözme Konusundaki Yetersizlikleri ve Problem Çözümlerindeki Hataları

Directory of Open Access Journals (Sweden)

Dilek Sezgin Memnun

2014-08-01

Full Text Available In this research, it was aimed to determine the deficiencies of secondary school fifth- and sixth-grade students on word problem solving and their failures in this process. For this purpose, four separate word problems were asked to the students and their written answers were taken at the implementation process. The analysis of the data suggests that a significant part of these secondary school students had deficiencies during word problem solving and their failures in this process. Moreover, these deficiencies and failures were reported to be related to the understanding of word problems and the planning for solutions in the solving process. In addition, it was found that the fifth- and sixth- grade students rarely attempted to use drawing in order to solve the word problems. They mostly had deficiencies in deciding which arithmetic operations to be used while approaching the problems and they had failures at their arithmetic operations. [Bu araştırmada, ortaokul beşinci ve altıncı sınıf öğrencilerinin sözel problemleri çözme konusundaki yetersizlikleri ile bu tür problem çözümlerindeki hatalarının belirlenmesi amaçlanmıştır. Bu amaçla, beşinci ve altıncı sınıf öğrencilerine dört farklı sözel problem sorulmuş ve cevapları yazılı olarak alınmıştır. Ulaşılan verilerin analizi, ortaokul öğrencilerinin önemli bir kısmının sözel problemleri çözme konusunda yetersizlikleri ve problem çözümlerinde hataları bulunduğunu göstermiştir. Ayrıca, bu yetersizlik ve hatalarının çoğunlukla problem çözme süreci kapsamında problemin anlaşılması ve çözüm için plan yapma aşamalarına ilişkin olduğu belirlenmiştir. Bununla birlikte, beşinci ve altıncı sınıf öğrencilerinin sözel problem çözümlerinde şekil çizmeye çok az yer verdikleri anlaşılmıştır. Öğrenciler problemlere yaklaşımlarında kullanacakları uygun aritmetik işlemlere karar vermede çoğunlukla yetersiz

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

DEFF Research Database (Denmark)

Brorsson, Caroline Anna; Pociot, Flemming

2015-01-01

) in autoimmune gastritis, transglutaminase (TGA) in celiac disease, and 21-hydroxylase (21-OHA) in autoimmune hypoadrenalism. In addition to the MHC region, we identify SNPs in five susceptibility loci (IFIH1, PTPN22, SH2B3, BACH2, and CTLA4) as significantly associated with more than one autoantibody at a false...

Untitled

Indian Academy of Sciences (India)

in germinating seeds. Indeed, Lintner (1890) and later, Lüers (1920) attribute the origin of the enzyme to oxidation of proteins. Since many of the earlier studies were conducted without adequate control of acidity, it is difficult to assess the precise significance of those findings (Waldschmidt-. Leitz, 1929). Bach and Oparin ...

History of Baroque Music in Brief.

Science.gov (United States)

Music Educators Journal, 1985

1985-01-01

The year 1985 marks the 300th birthday of three masters of Baroque music: Johann Sebastian Bach, George Frederic Handel, and Dominico Scarlatti. A summary of the history of Baroque music and a profile of the three composers, which can be used to teach secondary students about the period, are provided. (RM)

Health SA Gesondheid - Vol 12, No 2 (2007)

African Journals Online (AJOL)

Post-traumatic stress disorder and exposure to violence among Venda and Northern Sotho adolescents · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. K.G.F Esterhuyse, D.A Louw, J.M Bach. http://dx.doi.org/10.4102/hsag.v12i2.250 ...

Effect of Sprouting on invitro digestibility of some locally consumed ...

African Journals Online (AJOL)

DR. MIKE HORSFALL

Functional properties of lipid seed oil. (Lupinus metabilis) proteins and protein concentration. Journal of Food Science. 47: 491-. 497. (Taugo, L.C., Donangelo, C.M., Taugo, N.M.F. and. Knudsen-Bach, K.E. (2000)). Effect of heat treatment on nutritional quality of germinated legume seed J. Agric. Food Chem. 48: 2082-.

Author Details

African Journals Online (AJOL)

Bach, HS. Vol 20 (2003) - Articles Environmental Education Policy Processes in the Southern African Region Abstract PDF. ISSN: 2411-5959. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

HLA DQJ3 restriction fragment length polymorphism and ...

African Journals Online (AJOL)

1991-03-16

Mar 16, 1991 ... We should like to thank Dr Fritz Bach, University of Minnesota, for generously providing the DQf3 probe; Dr R. Martell for his advice and constructive criticism; Chris Martin and Derek Taljaard for technical assistance and Veronique Bruneau for typing the manuscript. This work was supported by grants from ...

Fulltext PDF

Indian Academy of Sciences (India)

contenders for this privilege. Of course, it would be so nice if one could smuggle in. The Character of Physical Law as well, and perhaps also ... V Balakrishnan, Department of Physics, Indian. Institute of Technology, Chennai 600 036, India. Wolfgang Pauli with Albert Einstein. Leiden. J 926. --______ ,~AAAL. ______ __.

Fulltext PDF

Indian Academy of Sciences (India)

776 Good Times in Tubingen. Wolfgang Engelmann. REFLECTIONS. 778 A Crab in the Lab that Identified High and Low Tides in the Sea Two Miles Away. The Rediscovery of Tidal Rhythms in India. M K Chandrashekaran. 784 Darshana Jolts. More on Matter. V V Raman. Information &. Announcements. XXXIII Refresher.

Cost Benefit Analysis of Performing a Pilot Project for Hydrogen-Powered Ground Support Equipment at Lemoore Naval Air Station

Science.gov (United States)

2006-12-01

34 Bullnet eCommerce Solutions, Bull Group. http://www.bullnet.co.uk/ (accessed November 25, 2006). 13 Philip Baxley, Cynthia Verdugo-Peralta, and Wolfgang...Benefits of Fuel Cells." Bullnet eCommerce Solutions, Bull Group. http://www.bullnet.co.uk/ (accessed November 25, 2006). "Hydrogen Production and

Global Tuberculosis Report 2016

Science.gov (United States)

... Alt+0 Navigation Alt+1 Content Alt+2 Tuberculosis (TB) Menu Tuberculosis Data and statistics Regional Framework Resources Meetings and events Global tuberculosis report 2017 WHO has published a global TB ...

An accelerated life test model for harmonic drives under a segmental stress history and its parameter optimization

Directory of Open Access Journals (Sweden)

Zhang Chao

2015-12-01

Full Text Available Harmonic drives have various distinctive advantages and are widely used in space drive mechanisms. Accelerated life test (ALT is commonly conducted to shorten test time and reduce associated costs. An appropriate ALT model is needed to predict the lifetime of harmonic drives with ALT data. However, harmonic drives which are used in space usually work under a segmental stress history, and traditional ALT models can hardly be used in this situation. This paper proposes a dedicated ALT model for harmonic drives applied in space systems. A comprehensive ALT model is established and genetic algorithm (GA is adopted to obtain optimal parameters in the model using the Manson fatigue damage rule to describe the fatigue failure process and a cumulative damage method to calculate and accumulate the damage caused by each segment in the stress history. An ALT of harmonic drives was carried out and experimental results show that this model is acceptable and effective.

Number 13 / Part I. Music. 3. Mad Scenes: A Warning against Overwhelming Passions

Directory of Open Access Journals (Sweden)

Marisi Rossella

2017-03-01

Full Text Available This study focuses on mad scenes in poetry and musical theatre, stressing that, according to Aristotle’s theory on catharsis and the Affektenlehre, they had a pedagogical role on the audience. Some mad scenes by J.S. Bach, Handel and Mozart are briefly analyzed, highlighting their most relevant textual and musical characteristics.

Thickenings and conformal gravity

Science.gov (United States)

Lebrun, Claude

1991-07-01

A twistor correspondence is given for complex conformal space-times with vanishing Bach and Eastwood-Dighton tensors; when the Weyl curvature is algebraically general, these equations are precisely the conformal version of Einstein's vacuum equations with cosmological constant. This gives a fully curved version of the linearized correspondence of Baston and Mason [B-M].

Thickenings and conformal gravity

International Nuclear Information System (INIS)

LeBrun, C.

1991-01-01

A twistor correspondence is given for complex conformal space-times with vanishing Bach and Eastwood-Dighton tensors; when the Weyl curvature is algebraically general, these equations are precisely the conformal version of Einstein's vacuum equations with cosmological constant. This gives a fully curved version of the linearized correspondence of Baston and Mason [B-M]. (orig.)

A note on a generalisation of Weyl's theory of gravitation

International Nuclear Information System (INIS)

Dereli, T.; Tucker, R.W.

1982-01-01

A scale-invariant gravitational theory due to Bach and Weyl is generalised by the inclusion of space-time torsion. The difference between the arbitrary and zero torsion constrained variations of the Weyl action is elucidated. Conformal rescaling properties of the gravitational fields are discussed. A new class of classical solutions with torsion is presented. (author)

Supertwistor connection and conformal supergravity

International Nuclear Information System (INIS)

Merkulov, S.A.

1985-01-01

Supersymmetry expansion of the geometry of local twistors is suggested. Definition of the space of local supertwistors is given and its differential geometry is formulated. Variational principles are discussed, and it is shown that corresponding Euler-Lagrange equations also coincide and result in superzero equations of N=1 conformal supergravitation, which generalize Bach equations

Author Details

African Journals Online (AJOL)

Bach, J.M. Vol 12, No 2 (2007) - Articles Post-traumatic stress disorder and exposure to violence among Venda and Northern Sotho adolescents. Abstract PDF. ISSN: 2071-9736. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

NEW LOCALITY RECORDS FOR CROCIDURA MARIQUENSIS

African Journals Online (AJOL)

bach and N Oippenaar for information on distribu- tion and habitat of the species. REFERENCES. DAVIS, D H S 1958. Degree-sqWU'e distribution diagrams: mapping system in use at the Medical. Ecology Centre, Johannesburg. In Cartography of vectors of disease, Bakavu-Lwiro. eCTAl. CSA Pub!. 29: 49-53. LYNCH, C D ...

High-performance ceramics - state of the art and trends of development

International Nuclear Information System (INIS)

Gadow, R.; Keizer, K; Burggraaf, A.J.; Boch, P.; Chartier, T.; Thomann, H.

1989-01-01

This paper contains 4 lectures on the following topics: 1. fiber and whisker reinforced ceramics (R. Gadow), 2. ceramic membranes (K. Keizer, A.J. Burggraf), 3. ceramic processing techniques: The case of tape casting (P. Bach, T. Chartier), 4. ceramic superconductors (H. Thomann). Three contributions are separately analyzed for the ENERGIE database. (MM) [de