WorldWideScience

Sample records for azido compounds

  1. Synthesis, characterization, thermal and computational studies of novel tetra-azido compounds as energetic plasticizers

    Science.gov (United States)

    Baghersad, Mohammad Hadi; Habibi, Azizollah; Heydari, Akbar

    2017-02-01

    In this paper, four azido compounds have been synthesized and characterized as new energetic plasticizers. Nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy, elemental analysis, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and differential thermal analysis (DTA) have been used to identify and determine the properties of the synthesized plasticizers. The plasticization effect of plasticizers on glycidyl azide polymer (GAP) has been investigated by viscosity measurements and thermal analysis of the prepolymer-plasticizer mixtures and plasticized binders. The plasticized mixtures were cured by a diisocyanate curing agent and the glass transition temperature and decomposition temperature of the cured polyurethane binders were measured. Thermal analysis of the prepolymer-plasticizer and cured polymer mixtures showed that the synthesized plasticizers are completely compatible with the GAP binder and have a very good plasticizing effect. Furthermore, equilibrium geometry and heats of formation of each of the plasticizer molecules were obtained using the thermochemical T1 recipe, which is available in wave function Spartan software. Comparing empirical heats of combustion and calculated heats of combustion by using the heats of formation showed that the suggested optimum molecular structure by the T1 recipe has a high similarity to the real molecular structure of these molecules.

  2. Synthesis and Crystal Structure of a One-dimensional Azido-bridged Manganese (II) Compound [Mn(N3)2(H2O)3·C6H12N4]n

    Institute of Scientific and Technical Information of China (English)

    CHEN Hui; WANG Wen-Guo; ZHANG Xiao-Feng; CHEN Chang-Neng; LIU Qiu-Tian

    2006-01-01

    A new one-dimensional azido-bridged manganese compound has been prepared and structurally characterized by X-ray diffraction. The complex [Mn(N3)2(H2O)3·C6H12N4]n crystallizes in space group Pnma with a = 6.5252 (5), b = 9.3226(7), c = 22.2070(15)(A), V = 1350.89(17)(A)3, Z = 4, Mr = 333.24, Dc = 1.639 g/cm3, μ= 1.005 mm-1 and F(000) = 692. The final refinement gave R = 0.0328 and wR = 0.0777 for 1085 observed reflections with I > 2σ(I). The structure contains [Mn- (N3)2(H2O)3]n polymeric chains and uncoordinated hexamethylenetetramine (HMTA) molecules with Mn/HMTA molar ratio of 1:1. The Mn atoms are bridged by end-to-end azido ligands to construct one-dimensional zig-zag infinite chains. Each Mn atom is six-coordinated by three N atoms of three azido ligands and three water O atoms, resulting in an octahedral geometry. Extending hydrogen- bonding interactions involving water O atoms, azido and HMTA N atoms link the chains and HMTA molecules into a three-dimensional network.

  3. Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides.

    Science.gov (United States)

    Pícha, Jan; Buděšínský, Miloš; Macháčková, Kateřina; Collinsová, Michaela; Jiráček, Jiří

    2017-03-01

    The rise of CuI-catalyzed click chemistry has initiated an increased demand for azido and alkyne derivatives of amino acid as precursors for the synthesis of clicked peptides. However, the use of azido and alkyne amino acids in peptide chemistry is complicated by their high cost. For this reason, we investigated the possibility of the in-house preparation of a set of five Fmoc azido amino acids: β-azido l-alanine and d-alanine, γ-azido l-homoalanine, δ-azido l-ornithine and ω-azido l-lysine. We investigated several reaction pathways described in the literature, suggested several improvements and proposed several alternative routes for the synthesis of these compounds in high purity. Here, we demonstrate that multigram quantities of these Fmoc azido amino acids can be prepared within a week or two and at user-friendly costs. We also incorporated these azido amino acids into several model tripeptides, and we observed the formation of a new elimination product of the azido moiety upon conditions of prolonged couplings with 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate/DIPEA. We hope that our detailed synthetic protocols will inspire some peptide chemists to prepare these Fmoc azido acids in their laboratories and will assist them in avoiding the too extensive costs of azidopeptide syntheses. Experimental procedures and/or analytical data for compounds 3-5, 20, 25, 26, 30 and 43-47 are provided in the supporting information. © 2017 The Authors Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd.

  4. Dicyclohexylammonium (S-2-azido-3-phenylpropanoate

    Directory of Open Access Journals (Sweden)

    Sebastian J. Petrik

    2012-07-01

    Full Text Available The asymmetric unit of the title compound, C12H24N+·C9H8N3O2−, consists of two dicyclohexylammonium cations linked to two (S-2-azido-3-phenylpropanoate anions by four short N—H...O hydrogen bonds with N...O distances in the range 2.712 (3–2.765 (3 Å. The dicyclohexylammonium cations and the aryl and carboxylate groups of the anion are related by a pseudo-inversion centre, with overall crystallographic inversion symmetry for the structure broken by the chirality of the α-C atoms of the anions.

  5. Diazo transfer for azido-functional surfaces

    Directory of Open Access Journals (Sweden)

    Laura Russo

    2011-04-01

    Full Text Available Preparation of azido-functionalized polymers is gaining increasing attention. We wish to report an innovative, novel strategy for azido functionalization of polymeric materials, coupling plasma technology and solution processed diazo transfer reactions. This novel approach allows the azido group to be introduced downstream of the material preparation, thus preserving its physicochemical and mechanical characteristics, which can be tailored a priori according to the desired application. The whole process involves the surface plasma functionalization of a material with primary amino groups, followed by a diazo transfer reaction, which converts the amino functionalities into azido groups that can be exploited for further chemoselective reactions. The diazo transfer reaction is performed in a heterogeneous phase, where the azido group donor is in solution. Chemical reactivity of the azido functionalities was verified by subsequent copper-catalyzed azide-alkyne cycloaddition.

  6. Azido--meconine-`high ortho’ Novolak resin-based negative photoresists for deep UV lithography

    Indian Academy of Sciences (India)

    Maneesh Sharma; Anant A Naik; Manoj Gaur; P Raghunathan; S V Eswaran

    2009-07-01

    Photoactive chemicals blended with polymers, solvents and certain other additives serve as photoresists. A new photoactive compound (PAC), azido--meconine absorbing in the deep UV region has been blended with `alternating’ and `semi-alternating’ and `high ortho’ alternating novolak resins, based on /-cresol. The new photoresists have been evaluated as a negative tone deep UV photoresist for mircolithography.

  7. Water soluble azido polyisocyanopeptides as functional β-sheet mimics

    NARCIS (Netherlands)

    Schwartz, Erik; Koepf, Matthieu; Kitto, Heather J.; Espelt, Mónica; Nebot-Carda, Vicent J.; Gelder, de Rene; Nolte, Roeland J.M.; Cornelissen, Jeroen J.L.M.; Rowan, Alan E.

    2009-01-01

    The design and synthesis of functional biomimetic water soluble polymers with a defined secondary structure has been developed using β-sheet polyisocyanopeptide scaffolds. Water soluble isocyanopolymers were prepared by random copolymerisation of the azido functionalized isocyanopeptides with nonfun

  8. 5-Azido-4-dimethylamino-1-methyl-1,2,4-triazolium Hexafluoridophosphate and Derivatives

    Directory of Open Access Journals (Sweden)

    Gerhard Laus

    2016-02-01

    Full Text Available 5-Azido-4-(dimethylamino-1-methyl-1,2,4-triazolium hexafluoridophosphate was synthesized from the corresponding 5-bromo compound with NaN3. Reaction with bicyclo[2.2.1]hept-2-ene yielded a tricyclic aziridine, addition of an N-heterocyclic carbene resulted in a triazatrimethine cyanine, and reduction with triphenylphosphane gave the 5-amino derivative. The crystal structures of three nitrogen-rich salts were determined. Thermoanalysis of the cationic azide and triazene showed exothermal decomposition. The triazene exhibited negative solvatochromism in polar solvents involving the dipolarity π* and hydrogen-bond donor acidity α of the solvent.

  9. Synthesis and Consecutive Reactions of α-Azido Ketones: A Review

    Directory of Open Access Journals (Sweden)

    Sadia Faiz

    2015-08-01

    Full Text Available This review paper covers the major synthetic approaches attempted towards the synthesis of α-azido ketones, as well as the synthetic applications/consecutive reactions of α-azido ketones.

  10. 2-Azido-1-(4-nitrophenylethanone

    Directory of Open Access Journals (Sweden)

    Sammer Yousuf

    2012-06-01

    Full Text Available In the title compound, C8H6N4O3, the ketone [C—C(=O—C] and nitro groups are tilted with respect to the benzene ring by 18.92 (6 and 24.11 (15°, respectively. In the crystal, molecules are linked into interwoven chains running parallel to the [100] direction by C—H...N hydrogen bonds and weak π–π stacking interactions, with centroid–centroid separations of 3.897 (3 Å.

  11. Synthesis of 3I-O and 2I-O-monosubstituted derivatives of per-6-azido-β-cyclodextrin-potential molecular scaffolds.

    Science.gov (United States)

    Popr, Martin; Hybelbauerová, Simona; Jindřich, Jindřich

    2012-11-01

    Alkylation of per-6-azido-β-cyclodextrin by a suitable electrophilic reagent (cinnamyl bromide or propargyl bromide) gave a mixture of 3(I)-O and 2(I)-O regioisomers. After peracetylation and chromatographic separation on silica gel, pure isomers were isolated. Oxidative cleavage of cinnamyl double bond afforded the corresponding formylmethyl and carboxymethyl derivatives. The prepared scaffold molecules are equipped with two types of reactive groups which have a potential to serve as points of attachment for various compounds.

  12. Rhomboidal [Cu4] coordination cluster from self-assembly of two asymmetric phenoxido-bridged Cu2 units: Role of 1,1-azido clips

    Indian Academy of Sciences (India)

    Avijit Sarkar; Aloke Kumar Ghosh; Moumita Pait; Haridas Mandal; Tufan Singha Mahapatra; Biswajit Sharangi; Mrinal Sarkar; Debashis Ray

    2012-11-01

    The coordination cluster [Cu2(-OMe)(1,1-N3)(-bcp)(N3)]2 (1; Hbcp = 2,6-bis(2-benzoyl-4-chloro-phenylimino)-methyl)-4-methylphenol, forming a new member within the rapidly growing family of Cu4 cluster complexes, has been synthesized and structurally characterized by X-ray crystallography. The complex crystallizes in the monoclinic system, space group P21/, with unit cell parameters a = 14.620(7) Å, b = 17.923(8) Å, c = 15.008(7) Å, = 115.815(14)° and Z = 2. It is the first example of a rhomboidal [Cu4] compound formed from 1,1-azido clipping of two methoxido bridged [Cu2] complexes showing asymmetric coordination from benzophenone oxygen atoms and terminal azido groups.

  13. Magnetocaloric effect and slow magnetic relaxation in two only azido bridged ferromagnetic tetranuclear metal clusters.

    Science.gov (United States)

    Zhao, Jiong-Peng; Zhao, Ran; Yang, Qian; Hu, Bo-Wen; Liu, Fu-Chen; Bu, Xian-He

    2013-10-28

    Two M(II) tetranuclear complexes bridged only by azido, Mn4(N3)(7.3)Cl(0.7)L4 (1) and Co4(N3)8L4 (2) in which the four M(II) ions are precisely coplanar bridged only by six azido anions, were obtained by using 4,5-diazafluoren-9-one (L) as a corner ligand. Magnetic studies indicate that ferromagnetic coupling was conducted by the azido anions between M(II) ions. At low temperature, 1 exhibits a large magnetocaloric effect and 2 shows field-induced multiple magnetic relaxations.

  14. Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

    Directory of Open Access Journals (Sweden)

    Jana Krejzová

    2014-03-01

    Full Text Available NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C-6 position. Dimerization of NAG-thiazoline via C-6 attached triazole linkers prepared by click chemistry was employed to make use of multivalency in the inhibition. Novel compounds were tested as potential inhibitors of β-N-acetylhexosaminidases from Talaromyces flavus, Streptomyces plicatus (both GH20 and β-N-acetylglucosaminidases from Bacteroides thetaiotaomicron and humans (both GH84. From the set of newly prepared NAG-thiazoline derivatives, only C-6-azido-NAG-thiazoline displayed inhibition activity towards these enzymes; C-6 triazole-substituted NAG-thiazolines lacked inhibition activity against the enzymes used. Docking of C-6-azido-NAG-thiazoline into the active site of the tested enzymes was performed. Moreover, a stability study with GlcNAc-thiazoline confirmed its decomposition at pH < 6 yielding 2-acetamido-2-deoxy-1-thio-α/β-D-glucopyranoses, which presumably dimerize oxidatively into S-S linked dimers; decomposition products of NAG-thiazoline are void of inhibitory activity.

  15. Synthesis and Characterisation of Bis-azido Methyl Oxetane and its Polymer and Copolymer with Tetrahydrofuran

    Directory of Open Access Journals (Sweden)

    J. K. Nair

    2002-04-01

    Full Text Available Bis-azido methyl oxetane (BAMO was synthesised from pentaerythritol in two steps. Pentaerythritol was chlorinated to yield a mixture of mono, di, tri and tetra chloro compounds. The trichloro compound on ring closure gives bis-chloro methyl oxetane (BCMO. It was reacted with sodium azide in aqueous medium to obtain BAMO. The latter was polymerised using BF3 etherate catalyst and 1,4-butanediol initiator. Similarly, the BAMO- THF copolymer was also synthesised. All the monomers and polymers were characterised by IR, 1H-NMR, 13C-NMR, and refractive index. The polymers were also characterised for molecular weight, hydroxyl value, etc. Thermal analysis showed that both polymers degrade exothermically with T max of 237 °C for poly BAMO and 241°C for BAMO- THF copolymer with activation energy of 39 kcal/mol and 40 kcal/mol, respectively. Explosive properties like impact and friction sensitivity of BAMO and the other polymers were also determined.

  16. Diversity of azido magnetic chains constructed with flexible ligand 2,2'-dipyridylamine.

    Science.gov (United States)

    Wang, Xiu-Teng; Wang, Xiao-Hua; Wang, Zhe-Ming; Gao, Song

    2009-02-16

    By employing a flexible molecule, 2,2'-dipyridylamine (dpa), as a bidentate coligand, three azide-bridged one-dimensional coordination polymers, [M(dpa)(N(3))(2)](n) (M = Cu, 1.Cu; Co, 2.Co) and [Ni(dpa)(OAc)(0.5)(N(3))(1.5)(H(2)O)](n) (3.Ni), have been successfully synthesized and structurally and magnetically characterized. They show versatile one-dimensional chain structures. 1.Cu is an EO-N(3) bridged uniform chain; 2.Co is an alternative chain linked by two EO-N(3) and two EE-N(3) bridges. Interestingly, 3.Ni is a zigzag chain linked alternatively by one EE-N(3) and a novel 3-fold bridge, which is composed of two EO-N(3) and one acetate group. This series of azido complexes demonstrates that the flexibility of the dpa ligand plays an important role in directing the structures of the final products. Magnetic studies reveal dominant intrachain antiferromagnetic couplings in compound 1.Cu. Compounds 2.Co and 3.Ni are weak ferromagnets due to the spin canting, with critical temperatures of 12.4 and 32.5 K, respectively.

  17. Synthesis and Crystal Structure of 4-Azido-2,2,6,6-Tetramethylpiperidine-1-oxyl Free Radical

    Institute of Scientific and Technical Information of China (English)

    ZHOU Bao-Han; CHEN Yun-Feng; YIN Guo-Dong; WU An-Xin

    2006-01-01

    The title compound 4-azido-2,2,6,6-tetramethylpiperidine-1-oxyl (C9H17N4O, Mr = 197.27) has been synthesized and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to triclinic, space group P(1-) with a = 5.8464(12), b = 8.2476(17), c = 11.954(2)(A), α = 101.973(4), β = 97.186(3), γ = 100.232(3)°, V = 546.98(19)(A)3, Z = 2, Dc = 1.198 g/cm3, μ(MoKα) = 0.082 mm-1, F(000) = 214, R = 0.0495 and wR = 0.1355 for 1677 observed reflections with I > 2σ(I). X-ray analysis reveals that the six-membered ring adopts a chair conformation and the bond length of N(1)-O(1) is 1.2838(19)(A).

  18. The azido oxide N{sub 3}O

    Energy Technology Data Exchange (ETDEWEB)

    Petris, Giulia de [Dipartimento di Chimica e Tecnologie del Farmaco, Universita ' La Sapienza' , P.le Aldo Moro 5, 00185 Roma (Italy); Troiani, Anna, E-mail: anna.troiani@uniroma1.it [Dipartimento di Chimica e Tecnologie del Farmaco, Universita ' La Sapienza' , P.le Aldo Moro 5, 00185 Roma (Italy); Rosi, Marzio [Dipartimento di Ingegneria Civile e Ambientale, Universita di Perugia and ISTM-CNR, Perugia (Italy); Sgamellotti, Antonio [Dipartimento di Chimica, Universita di Perugia and ISTM-CNR, Perugia (Italy); Cipollini, Romano [Dipartimento di Chimica e Tecnologie del Farmaco, Universita ' La Sapienza' , P.le Aldo Moro 5, 00185 Roma (Italy)

    2012-04-04

    Graphical abstract: N{sub 3}O{sup +} ions prepared in the source of a mass spectrometer under low-pressure conditions are submitted to neutralization by collisional electron transfer, leading to the observation of the novel N{sub 3}O oxide. Highlights: Black-Right-Pointing-Pointer The study reports the positive detection in the gas phase of the novel azido oxide N{sub 3}O. Black-Right-Pointing-Pointer It has been prepared by collisional electron transfer to the N{sub 3}O{sup +} ion and observed on a microsecond time scale. Black-Right-Pointing-Pointer The oxide has been assigned a minimum lifetime of 0.7 {mu}s and an open-chain structure of NNNO connectivity. Black-Right-Pointing-Pointer The study examines the role of excited species in the formation of covalently bound ions suitable to neutralization. - Abstract: The new nitrogen-rich oxide N{sub 3}O has been detected in the gas phase by mass spectrometric experiments. The radical has been assigned a minimum lifetime of 0.7 {mu}s and an open-chain NNNO structure in the quartet state. Structures and energies of the N{sub 3}O{sup +} precursor ion and the N{sub 3}O radical have been investigated by ab initio calculations.

  19. Synthesis of amino, azido, nitro, and nitrogen-rich azole-substituted derivatives of 1H-benzotriazole for high-energy materials applications.

    Science.gov (United States)

    Srinivas, Dharavath; Ghule, Vikas D; Tewari, Surya P; Muralidharan, Krishnamurthi

    2012-11-19

    The amino, azido, nitro, and nitrogen-rich azole substituted derivatives of 1H-benzotriazole have been synthesized for energetic material applications. The synthesized compounds were fully characterized by (1)H and (13)C NMR spectroscopy, IR, MS, and elemental analysis. 5-Chloro-4-nitro-1H-benzo[1,2,3]triazole (2) and 5-azido-4,6-dinitro-1H-benzo[1,2,3]triazole (7) crystallize in the Pca2(1) (orthorhombic) and P2(1)/c (monoclinic) space group, respectively, as determined by single-crystal X-ray diffraction. Their densities are 1.71 and 1.77 g cm(-3), respectively. The calculated densities of the other compounds range between 1.61 and 1.98 g cm(-3). The detonation velocity (D) values calculated for these synthesized compounds range from 5.45 to 8.06 km s(-1), and the detonation pressure (P) ranges from 12.35 to 28 GPa.

  20. First Synthesis and Isolation of the E- and Z-Isomers of Some New Schiff Bases. Reactions of 6-Azido-5-Formyl-2-Pyridone with Aromatic Amines

    Directory of Open Access Journals (Sweden)

    Kamal U. Sadek

    2008-01-01

    Full Text Available Some novel Schiff bases have been prepared by reacting 6-azido-5-formyl-2-pyridone 1 with a series of aromatic amines 2a-f. 5-Arylaminomethylene-6-(E-aryliminopyridones3a-e were obtained by reaction of 1 with 2a-e at room temperature,whereas with 2f, the 6-azido-5-naphthalen-2-yl-iminomethylpyridone derivative 4 wasformed. On the other hand, heating 1 with 2a-d at 140-150°C yielded two sets of isomericproducts, (E-3a-d and (Z-5a-d. Refluxing compounds (Z-3a,c with hydroxyl-amine inmethanol gave the corresponding hydroxyliminopyridones 8a,c. Heating of (E-3a-d withexcess POCl3 at reflux did not give the expected tricyclic compound 9, but rather theisomeric products (Z-5a-d were obtained. The structures of all these products have beencharacterized using IR and 1H- and 13C-NMR spectroscopy.

  1. Synthesis of azido-functionalized carbohydrates for the design of glycoconjugates.

    Science.gov (United States)

    Cecioni, Samy; Goyard, David; Praly, Jean-Pierre; Vidal, Sébastien

    2012-01-01

    As carbohydrates play a major role in numerous biological processes through their interactions with lectins and also appear as one of the most crucial post-translational modifications of proteins, chemists have developed several approaches for the design of glycoconjugates based on a series of conjugation methodologies. The recent development of copper(I)-catalyzed azide-alkyne cycloaddition (CuACC) paved the way to a novel conjugation strategy in which azido-functionalized carbohydrate derivatives can be readily connected to alkyne-functionalized (bio)molecules. This so-called "click chemistry" methodology has now found numerous applications both in chemistry and biology. The azido moiety can be introduced either directly at the anomeric carbon of the carbohydrate derivative, or attached to a spacer arm. We describe here the syntheses of 2,3,4,6-tetra-O-acetyl-β-D: -glucopyranosyl azide as well as 1-azido-3,6-dioxaoct-8-yl 2,3,4,6-tetra-O-acetyl-β-D: -galactopyranoside and 1-azido-3,6-dioxaoct-8-yl 2,3,6,2',3',4',6'-hepta-O-acetyl-β-D: -lactoside. These molecules can then be used in the construction of glycoconjugates to find applications in chemical biology.

  2. Synthesis and Photochromic Properties of Azido Analogues of Spiropyran and Spirooxazine as Nucleic Acid Labeling Reagent

    Institute of Scientific and Technical Information of China (English)

    Hui GUO; Wu Xin ZOU; Qi JI; Ji Ben MENG

    2005-01-01

    A series of photo active azido analogues have been synthesized and their photochromic properties have also been investigated by UV-Vis spectrum. It will be used for the rapid and reliable preparation of large amounts of stable, non-radioactive labeled DNA and RNA hybridization probes. And it is supposed to be easily detected for its photochromic properties.

  3. Crystal structures of μ-oxalato-bis[azido(histaminecopper(II] and μ-oxalato-bis[(dicyanamido(histaminecopper(II

    Directory of Open Access Journals (Sweden)

    Chen Liu

    2015-11-01

    Full Text Available The title compounds, μ-oxalato-κ4O1,O2:O1′,O2′-bis[[4-(2-aminoethyl-1H-imidazole-κ2N3,N4](azido-κN1copper(II], [Cu2(C2O4(N32(C5H9N32], (I, and μ-oxalato-κ4O1,O2:O1′,O2′-bis[[4-(2-aminoethyl-1H-imidazole-κ2N3,N4](dicyanamido-κN1copper(II], [Cu2(C2O4(C2N32(C5H9N32], (II, are two oxalate-bridged dinuclear copper complexes. Each CuII ion adopts a five-coordinate square-pyramidal coordination sphere where the basal N2O2 plane is formed by two O atoms of the oxalate ligand and two N atoms of a bidentate chelating histamine molecule. The apical coordination site in compound (I is occupied by a monodentate azide anion through one of its terminal N atoms. The apical coordination site in compound (II is occupied by a monodentate dicyanamide anion through one of its terminal N atoms. The molecules in both structures are centrosymmetric. In the crystals of compounds (I and (II, the dinuclear complexes are linked through N—H...X and C—H...X (X = N, O hydrogen bonds where the donors are provided by the histamine ligand and the acceptor atoms are provided by the azide, dicyanamide, and oxalate ligands. In compound (I, the coordinatively unsaturated copper ions interact with the histamine ligand via a C—H...Cu interaction. The coordinatively unsaturated copper ions in compound (II interact via a weak N...Cu interaction with the dicyanamide ligand of a neighboring molecule. The side chain of the histamine ligand is disordered over three sets of sites in (II.

  4. Unexpected cleavage of 2-azido-2-(hydroxymethyl)oxetanes: conformation determines reaction pathway?

    Science.gov (United States)

    Farber, Elisa; Herget, Jackson; Gascón, José A; Howell, Amy R

    2010-11-19

    An unanticipated cleavage of 2-azido-2-(hydroxymethyl)oxetanes is reported. In attempts to oxidize the title oxetanyl alcohols to the corresponding carboxylic acids with RuO4, cleaved nitriles were formed as the sole isolable products, while a closely related tetrahydrofuran gave solely the expected carboxylic acid. Quantum chemical calculations suggest that the divergent outcomes are governed by conformational differences in the azidoalcohols.

  5. Evaluation of the combination effect of different antiviral compounds against HIV in vitro

    DEFF Research Database (Denmark)

    Sørensen, A M; Nielsen, C; Mathiesen, Lars Reinhardt;

    1993-01-01

    3'-azido-3'deoxythymidine (AZT), a clinically used anti-HIV compound, was evaluated for antiviral effect on HIV infection in combination with other antiviral compounds in vitro. Interactions were evaluated by the median-effect principle and the isobologram technique. Synergistic effect was obtained...

  6. Rational design of novel anti-microtubule agent (9-azido-noscapine) from quantitative structure activity relationship (QSAR) evaluation of noscapinoids.

    Science.gov (United States)

    Santoshi, Seneha; Naik, Pradeep K; Joshi, Harish C

    2011-10-01

    An anticough medicine, noscapine [(S)-3-((R)4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,7-dimethoxyiso-benzofuran-1(3H)-one], was discovered in the authors' laboratory as a novel type of tubulin-binding agent that mitigates polymerization dynamics of microtubule polymers without changing overall subunit-polymer equilibrium. To obtain systematic insight into the relationship between the structural framework of noscapine scaffold and its antitumor activity, the authors synthesized strategic derivatives (including two new ones in this article). The IC(50) values of these analogs vary from 1.2 to 56.0 µM in human acute lymphoblastic leukemia cells (CEM). Geometrical optimization was performed using semiempirical quantum chemical calculations at the 3-21G* level. Structures were in agreement with nuclear magnetic resonance analysis of molecular flexibility in solution and crystal structures. A genetic function approximation algorithm of variable selection was used to generate the quantitative structure activity relationship (QSAR) model. The robustness of the QSAR model (R(2) = 0.942) was analyzed by values of the internal cross-validated regression coefficient (R(2) (LOO) = 0.815) for the training set and determination coefficient (R(2) (test) = 0.817) for the test set. Validation was achieved by rational design of further novel and potent antitumor noscapinoid, 9-azido-noscapine, and reduced 9-azido-noscapine. The experimentally determined value of pIC(50) for both the compounds (5.585 M) turned out to be very close to predicted pIC(50) (5.731 and 5.710 M).

  7. Specific labelling of the (Ca2+ + Mg2+)-ATPase of Escherichia coli with 8-azido-ATP and 4-chloro-7-nitrobenzofurazan.

    Science.gov (United States)

    Verheijen, J H; Postma, P W; van Dam, K

    1978-05-10

    1. 8-Azido-ATP is a substrate for Escherichia coli (Ca2+ + Mg2+)-ATPase (E. coli F1). 2. Illumination of E. coli F1 in the presence of 8-azido-ATP causes inhibition of ATPase activity. The presence of ATP during illumination prevents inhibition. 3. 8-Azido-ATP and 4-chloro-7-nitrobenzofurazan (NbfCl) bind predominantly to the alpha subunit of the enzyme, but also significantly to the beta subunit. 4. The alpha subunit of E. coli F1 seems to have some properties that in other F1-ATPases are associated with the beta subunit.

  8. In vivo toxicity of 3 prime -azido-3 prime -deoxythymidine (AZT) on CBA/Ca mice

    Energy Technology Data Exchange (ETDEWEB)

    Cronkite, E.P.; Bullis, J. (Brookhaven National Laboratory, Upton, NY (USA))

    1990-09-01

    CBA/Ca male mice were given 3'-azido-3'-deoxythymidine (AZT) in drinking water (1 mg/ml) for up to 7 weeks. Water consumption and body weight decreased significantly. Neutropenia and lymphopenia were observed during and after exposure. Significant macrocytic anemia developed and disappeared as a function of red cell life span after stopping AZT intake. A microthrombocytosis was seen. Bone marrow cellularity and spleen colony-forming unit (CFU-s) content fell, but recovered completely and quickly after terminating AZT intake. Hemopoietic stem cell function measured by 2 different methods of rescuing fatally irradiated mice was normal 4 weeks after AZT exposure, suggesting that AZT treatment does not induce a long-lasting effect in genetic control of mitotic potential of stem cells. This is in marked contrast to exposure of CBA/Ca mice to benzene and ionizing radiation.

  9. Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin

    Science.gov (United States)

    Hicks, G. R.; Rayle, D. L.; Jones, A. M.; Lomax, T. L.

    1989-01-01

    Plasma membrane vesicles were isolated from zucchini (Cucurbita pepo) hypocotyl tissue by aqueous phase partitioning and assessed for homogeneity by the use of membrane-specific enzyme assays. The highly pure (ca. 95%) plasma membrane vesicles maintained a pH differential across the membrane and accumulated a tritiated azido analogue of 3-indoleacetic acid (IAA), 5-azido-[7-3H]IAA ([3H]N3IAA), in a manner similar to the accumulation of [3H]IAA. The association of the [3H]N3IAA with membrane vesicles was saturable and subject to competition by IAA and auxin analogues. Auxin-binding proteins were photoaffinity labeled by addition of [3H]N3IAA to plasma membrane vesicles prior to exposure to UV light (15 sec; 300 nm) and detected by subsequent NaDodSO4/PAGE and fluorography. When the reaction temperature was lowered to -196 degrees C, high-specific-activity labeling of a 40-kDa and a 42-kDa polypeptide was observed. Triton X-100 (0.1%) increased the specific activity of labeling and reduced the background, which suggests that the labeled polypeptides are intrinsic membrane proteins. The labeled polypeptides are of low abundance, as expected for auxin receptors. Further, the addition of IAA and auxin analogues to the photoaffinity reaction mixture resulted in reduced labeling that was qualitatively similar to their effects on the accumulation of radiolabeled IAA in membrane vesicles. Collectively, these results suggest that the radiolabeled polypeptides are auxin receptors. The covalent nature of the label should facilitate purification and further characterization of the receptors.

  10. 苯的硝基和叠氮基衍生物的理论研究%Theoretical Studies on the Nitro and Azido Derivatives of Benzene

    Institute of Scientific and Technical Information of China (English)

    杜洪臣; 许晓娟; 刘彦; 刘卉; 王芳; 张建英; 贡雪东

    2011-01-01

    The geometries of the nitro and azido substituted derivatives of benzene were optimized at the B3LYP/6-31G* level of density functional theory, the detonation velocity and pressure were calculated with the Kamlet-Jacobs method and eleven candidates satisfying the energetic requirements for high energy density compound (HEDC) were found. The bond dissociation energies (BDE) of the possible trigger bonds were computed for these candidates and the activation energy (Ea) of the pyrolysis process following "furoxan mechanism" were also evaluated for the candidates with the adjacent nitro and azido groups. The calculated results show that Ea is much lower than BDE, implying that when there are adjacent azido and nitro groups in molecule, the stability of compounds will be greatly decreased and the pyrolysis happens in "furoxan mechanism". Otherwise, the pyrolysis will be initiated from the rupture of C-NO2 or C-N3 bond.The calculated BDE are essentially larger than 200 kJ/mol and all Ea are larger than 100 kJ/mol, therefore,the eleven candidates basically satisfy the energetic and stability requirements as HEDC.%在密度泛函理论B3LYP/6-31G*水平下优化了91个苯的硝基(NO2)和叠氮基(N3)衍生物的分子几何构型,预测了它们的密度和生成热,采用Kamlet-Jacobs方法计算了爆速和爆压,筛选得到11种爆轰性能较好的高能量密度化合物(HEDC),计算了它们的多个可能的热解引发键的键离解能(BDE)以及按"氧化呋咱机理"分解时的活化能(Ea).结果表明,当分子中有NO2与N3相邻时,分解按"氧化呋咱机理"进行,分解反应的Ea均大于100 kJ/mol;分子中没有NO2和N3相邻时,热解始于C-NO2或C-N3均裂,裂解的BDE都大于200 kJ/mol.只含NO2或N3的7个物质的稳定性好于同时含NO2和N3的物质,而只含N3的物质的稳定性又好于只含NO2的物质,五叠氮苯和六叠氮苯具有很出色的爆轰性能和稳定性.无论是能量还是稳定性方面.筛选得到的11种物质基本符合HEDC的要求.

  11. Synthesis of ferrocene-labeled steroids via copper-catalyzed azide-alkyne cycloaddition. Reactivity difference between 2β-, 6β- and 16β-azido-androstanes.

    Science.gov (United States)

    Fehér, Klaudia; Balogh, János; Csók, Zsolt; Kégl, Tamás; Kollár, László; Skoda-Földes, Rita

    2012-06-01

    Copper-catalyzed cycloaddition of steroidal azides and ferrocenyl-alkynes were found to be an efficient methodology for the synthesis of ferrocene-labeled steroids. At the same time, a great difference between the reactivity of 2β- or 16β-azido-androstanes and a sterically hindered 6β-azido steroid toward both ferrocenyl-alkynes and simple alkynes, such as phenylacetylene, 1-octyne, propargyl acetate and methyl propiolate, was observed.

  12. Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates.

    Science.gov (United States)

    Sanllehí, Pol; Abad, José-Luís; Bujons, Jordi; Casas, Josefina; Delgado, Antonio

    2016-11-10

    Two kinds of inhibitors of the PLP-dependent enzyme sphingosine-1-phosphate lyase have been designed and tested on the bacterial (StS1PL) and the human (hS1PL) enzymes. Amino phosphates 1, 12, and 32, mimicking the intermediate aldimines of the catalytic process, were weak inhibitors on both enzyme sources. On the other hand, a series of stereodefined azido phosphates, resulting from the replacement of the amino group of the natural substrates with an azido group, afforded competitive inhibitors in the low micromolar range on both enzyme sources. This similar behavior represents an experimental evidence of the reported structural similarities for both enzymes at their active site level. Interestingly, the anti-isomers of the non-natural enantiomeric series where the most potent inhibitors on hS1PL.

  13. Síntese e atividade citotóxica de alguns azido-ciclopaladados estabilizados com ligantes bifosfínicos Synthesis and cytotoxicity of some cyclometallated palladium (II complexes containing coordinated azide and diphosphines

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Fávero Caires

    1999-06-01

    Full Text Available Some cyclopalladated compounds containing the azido group ligand and the (C-N ring of N,N-dimethylbenzylamine have been prepared by bridge opening reactions of dimmer azide complex precursor with some diphosphines in different stoichiometric quantities. The neutral or ionic, mono or binuclear complexes synthesized were characterized by elemental analyses, I. R. spectroscopy and NMR techniques. The series of complexes was screened for cytotoxicity against a panel three human tumour cells lines(C6,Hep-2,HeLa. All complexes were found to be cytotoxic (IC50 at µM concentrations while one complex having the coordination bond N-Pd ruptured also displayed some differential cytotoxicity.

  14. Traceless Azido Linker for the Solid-Phase Synthesis of NH-1,2,3-Triazoles via Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions

    DEFF Research Database (Denmark)

    Cohrt, Anders Emil; Jensen, Jakob Feldthusen; Nielsen, Thomas Eiland

    2010-01-01

    A broadly useful acid-labile traceless azido linker for the solid-phase synthesis of NH-1,2,3-triazoles is presented. A variety of alkynes were efficiently immobilized on a range of polymeric supports by Cu(I)-mediated azide-alkyne cycloadditions. Supported triazoles showed excellent compatibility...

  15. Metabolic labeling of Caenorhabditis elegans primary embryonic cells with azido-sugars as a tool for glycoprotein discovery.

    Directory of Open Access Journals (Sweden)

    Amanda R Burnham-Marusich

    Full Text Available Glycobiology research with Caenorhabditis elegans (C. elegans has benefitted from the numerous genetic and cell biology tools available in this system. However, the lack of a cell line and the relative inaccessibility of C. elegans somatic cells in vivo have limited the biochemical approaches available in this model. Here we report that C. elegans primary embryonic cells in culture incorporate azido-sugar analogs of N-acetylgalactosamine (GalNAc and N-acetylglucosamine (GlcNAc, and that the labeled glycoproteins can be analyzed by mass spectrometry. By using this metabolic labeling approach, we have identified a set of novel C. elegans glycoprotein candidates, which include several mitochondrially-annotated proteins. This observation was unexpected given that mitochondrial glycoproteins have only rarely been reported, and it suggests that glycosylation of mitochondrially-annotated proteins might occur more frequently than previously thought. Using independent experimental strategies, we validated a subset of our glycoprotein candidates. These include a mitochondrial, atypical glycoprotein (ATP synthase α-subunit, a predicted glycoprotein (aspartyl protease, ASP-4, and a protein family with established glycosylation in other species (actin. Additionally, we observed a glycosylated isoform of ATP synthase α-subunit in bovine heart tissue and a primate cell line (COS-7. Overall, our finding that C. elegans primary embryonic cells are amenable to metabolic labeling demonstrates that biochemical studies in C. elegans are feasible, which opens the door to labeling C. elegans cells with other radioactive or azido-substrates and should enable the identification of additional post-translationally modified targets and analysis of the genes required for their modification using C. elegans mutant libraries.

  16. Synthesis and characterization of a 1D chain-like Cu{sub 6} substituted sandwich-type phosphotungstate with pendant dinuclear Cu–azido complexes

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yan-Ying [MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081 (China); Zhao, Jun-Wei, E-mail: zhaojunwei@henu.edu.cn [Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004 (China); Wei, Qi [State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Yang, Bai-Feng [MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081 (China); Yang, Guo-Yu, E-mail: ygy@bit.edu.cn [MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081 (China); State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China)

    2014-02-15

    A novel Cu–azido complex modified hexa-Cu{sup II} substituted sandwich-type phosphotungstate [Cu(en){sub 2}]([Cu{sub 2}(en){sub 2}(μ-1,1-N{sub 3}){sub 2}(H{sub 2}O)]{sub 2}[Cu{sub 6}(en){sub 2}(H{sub 2}O){sub 2}(B-α-PW{sub 9}O{sub 34}){sub 2}])·6H{sub 2}O (1) (en=ethylene-diamine) has been prepared under hydrothermal conditions and structurally characterized by elemental analyses, IR spectra, powder X-ray diffraction (PXRD) and single-crystal X-ray diffraction. 1 displays a beautiful 1-D chain architecture constructed from sandwich-type [Cu{sub 2}(en){sub 2}(μ-1,1-N{sub 3}){sub 2}(H{sub 2}O)]{sub 2}[Cu{sub 6}(en){sub 2}(H{sub 2}O){sub 2}(B-α-PW{sub 9}O{sub 34}){sub 2}]{sup 2−} units and [Cu(en){sub 2}]{sup 2+} linkers. To our knowledge, 1 represents the first hexa-Cu{sup II} sandwiched phosphotungstate with supporting Cu–azido complexes. - Graphical abstract: The first hexa-Cu{sup II} sandwiched phosphotungstate with supporting Cu–azido complexes has been prepared and characterized. Display Omitted - Highlights: • Hexa-copper-substituted phosphotungstate. • Cu–azido complexes modified hexa-Cu{sup II} substituted sandwich-type polyoxometalate. • 1-D chain architecture built by hexa-copper-substituted polyoxotungstate units.

  17. Multi-Fluorinated Azido Coumarins for Rapid and Selective Detection of Biological H2 S in Living Cells.

    Science.gov (United States)

    Zhu, Zhentao; Li, Yanyan; Wei, Chao; Wen, Xin; Xi, Zhen; Yi, Long

    2016-01-01

    Hydrogen sulfide (H2 S) is an endogenously produced gaseous signaling molecule with multiple biological functions. In order to visualize the endogenous in situ production of H2 S in living cells in real time, here we developed multi-fluorinated azido coumarins as fluorescent probes for the rapid and selective detection of biological H2 S. Kinetic studies indicated that an increase in fluorine substitution leads to an increased rate of H2 S-mediated reduction reaction, which is also supported by our theoretical calculations. To our delight, tetra-fluorinated coumarin 1 could react with H2 S fast (t1/2 ≈1 min) and selectively, which could be further used for continuous enzymatic assays and for visualization of intracellular H2 S. Bioimaging results obtained with 1 revealed that d-Cys could induce a higher level of endogenous H2 S production than l-Cys in a time-dependent manner in living cell.

  18. Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads.

    Science.gov (United States)

    Sun, Lingbo; Fu, Hongxia; Li, Yanru; Duan, Xinrui; Li, Zhengping

    2016-04-05

    New approach for colon cancer stem cells (CSCs) recognition and isolation is reported. Colon CSCs are responsible for colonic tumor growth, metastasis, and resistance for radio-/chemotherapies. An accurate identification and isolation method is critical for understanding and characterization of these cells. In our work, we recognized CSCs' population from colon cancer cells by using metabolic labeling of azido sugar based on the quiescent nature of these cells, which differed fundamentally from previously described methods by using specific cellular markers to recognize and isolate CSCs. Later the putative CSCs were isolated by using commercially available magnetic beads. The isolated cells population had much higher sphere formation efficiency, soft-agar colony formation efficiency, and an mRNA level of colon stem cells marker Lgr5 than the leftover population. Our method provides a new avenue and a general strategy for recognition and isolation of CSCs, which shows great potential for further use in both the fundamental research of CSCs and clinical tests.

  19. Synthesis and Biological Activities of a 3'-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells

    Directory of Open Access Journals (Sweden)

    Fengshan Wang

    2012-03-01

    Full Text Available Doxorubicin (DOX, an anthracycline antibiotic, is one of the most active anticancer chemotherapeutic agents. The clinical use of DOX, however, is limited by the dose-dependant P-glycoprotein (P-gp-mediated resistance. Herein, a 3′-azido analogue of DOX (ADOX was prepared from daunorubicin (DNR. ADOX exhibited potent antitumor activities in drug-sensitive (MCF-7 and K562 and drug-resistant cell lines (MCF-7/DNR, K562/DOX, respectively. The drug resistance index (DRI values of ADOX were much lower than that of DOX. The cytotoxicity experiments of ADOX or DOX against K562/DOX, with or without P-gp inhibitor, indicated that ADOX circumvents resistance by abolishing the P-gp recognition. This conclusion was further supported by drug influx/efflux flow cytometry experiments, as well as by molecular docking of ADOX to P-gp. In vivo animal tests, ADOX exhibited higher activity and less toxicity than DOX. The current data warranted ADOX for additional pre-clinical evaluations for new drug development.

  20. A novel high-spin tridecanuclear Ni(II) cluster with an azido-bridged core exhibiting disk-like topology.

    Science.gov (United States)

    Brunet, Gabriel; Habib, Fatemah; Cook, Cyril; Pathmalingam, Thushan; Loiseau, Francis; Korobkov, Ilia; Burchell, Tara J; Beauchemin, André M; Murugesu, Muralee

    2012-01-30

    A high-spin tridecanuclear Ni(II) cluster, [Ni(II)(13)(N(3))(18)(dpo)(4)(Hdpo)(2)(H(2)hpo)(4)(H(2)O)(MeOH)] [Ni(II)(13)(N(3))(18)(dpo)(4)(Hdpo)(2)(H(2)hpo)(4)(H(2)O)(2)] (1) (Hdpo = 1-(dimethylamino)propan-2-one oxime and H(2)hpo = 1-(hydroxyamino)propan-2-one oxime) with a purely azido-bridged core, is reported with dominant ferromagnetic coupling between Ni(II) ions. The latter molecule exhibits a unique planar core topology with the largest N(3)(-):Ni(II) ratio reported to date.

  1. In situ tetrazole templated chair-like decanuclear azido-cobalt(II) SMM containing both tetra- and octa-hedral Co(II) ions.

    Science.gov (United States)

    Zhang, Yuan-Zhu; Gao, Song; Sato, Osamu

    2015-01-14

    An azido-bridged chair-like decanuclear cluster: [Co(II)10(bzp)8(Metz)2(N3)18]·4MeOH·3H2O (1, bzp = 2-benzoylpyridine and HMetz = 5-methyl-1H-tetrazole) was prepared with in situ tetrazolate anions as templates in a sealed system. 1 containing both octahedral and tetrahedral Co(II) ions exhibited slow relaxation of magnetization with an effective barrier of 26 K under an applied dc field of 1 kOe.

  2. 邻羟基α-叠氮苯乙酮衍生物的合成%Synthesis of 2-Azido-1 - ( 2-hydroxyphenyl ) ethanone Derivatives

    Institute of Scientific and Technical Information of China (English)

    孟令国; 杨明明

    2011-01-01

    A series of 2-azido-1-(2-hydroxyphenyl)ethanone derivatives were successfully synthesized by bromination and azidation from 1-(2-hydroxyphenyl) ethanone derivatives. The structures were characterized by 1H NMR, 13C NMR, IR and HR-MS.%以邻羟基苯乙酮衍生物为原料,经溴化反应和叠氮化反应合成了一系列邻羟基α-叠氮苯乙酮衍生物,其结构经1H NMR,13C NMR,IR及HR-MS表征.

  3. Azido- and chlorido-cobalt complex as carrier-prototypes for antitumoral prodrugs.

    Science.gov (United States)

    Pires, Bianca M; Giacomin, Letícia C; Castro, Frederico A V; Cavalcanti, Amanda dos S; Pereira, Marcos D; Bortoluzzi, Adailton J; Faria, Roberto B; Scarpellini, Marciela

    2016-04-01

    Cobalt(III) complexes are well-suited systems for cytotoxic drug release under hypoxic conditions. Here, we investigate the effect of cytotoxic azide release by cobalt-containing carrier-prototypes for antitumoral prodrugs. In addition, we study the species formed after reduction of Co(3+) → Co(2+) in the proposed models for these prodrugs. Three new complexes, [Co(III)(L)(N3)2]BF4(1), [{Co(II)(L)(N3)}2](ClO4)2(2), and [Co(II)(L)Cl]PF6(3), L=[(bis(1-methylimidazol-2-yl)methyl)(2-(pyridyl-2-yl)ethyl)amine], were synthesized and studied by several spectroscopic, spectrometric, electrochemical, and crystallographic methods. Reactivity and spectroscopic data reveal that complex 1 is able to release N3(-) either after reduction with ascorbic acid, or by ambient light irradiation, in aqueous phosphate buffer (pH6.2, 7.0 and 7.4) and acetonitrile solutions. The antitumoral activities of compounds 1-3 were tested in normoxia on MCF-7 (human breast adenocarcinoma), PC-3 (human prostate) and A-549 (human lung adenocarcinoma epithelial) cell lines, after 24h of exposure. Either complexes or NaN3 presented IC50 values higher than 200 μM, showing lower cytotoxicity than the clinical standard antitumoral complex cisplatin, under the same conditions. Complexes 1-3 were also evaluated in hypoxia on A-549 and results indicate high IC50 data (>200 μM) after 24h of exposure. However, an increase of cancer cell susceptibility to 1 and 2 was observed at 300 μM. Regarding complex 3, no cytotoxic activity was observed in the same conditions. The data presented here indicate that the tridentate ligand L is able to stabilize both oxidation states of cobalt (+3 and +2). In addition, the cobalt(III) complex generates the low cytotoxic cobalt(II) species after reduction, which supports their use as as carrier prototypes for antitumoral prodrugs.

  4. Copper(II) coordination chain complex with the 2,5-bis(2-pyridyl)-1,3,4-thiadiazole ligand and an asymmetric μ2-1,1-azido double-bridged: Synthesis, crystal structure and magnetic properties

    Science.gov (United States)

    Laachir, Abdelhakim; Guesmi, Salaheddine; Saadi, Mohamed; El Ammari, Lahcen; Mentré, Olivier; Vezin, Hervé; Colis, Silviu; Bentiss, Fouad

    2016-11-01

    A new asymmetric μ2-1,1-azido double bridged cooper (II), with 2,5-bis(2-pyridyl)-1,3,4-thiadiazole (L), has been synthesized and characterized using single crystal X-ray diffraction, FT-IR, UV-Visible spectroscopic and magnetic measurements. The asymmetric unit of the title compound contains half molecule of formula, C12H8CuN10S, which crystallizes in the triclinic system, space group P 1 bar , with a = 6.5916 (4)Å, b = 10.6905 (7) Å, c = 11.5037 (7) Å, α = 106.508 (3)°, β = 105.538 (3)°, γ = 90.233 (4)°, V = 745.99 (8) Å3 and Z = 2. The structure consists of two [CuN5] prismatic polyhedra linked together by edge-sharing to build up a [Cu2N8] dimer arranged in chain. The connectivity along the chain is performed by Nsbnd N edge sharing between dimers. In the crystal, the molecules are linked together by Csbnd H⋯N hydrogen bonds and by π---π interactions between parallel pyridyl rings of neighboring molecules. The interpretation of FT-IR and UV-Vis spectra is consistent with the crystal structure determined by X-ray diffraction. The magnetic properties of the complex confirm the picture of an alternated … Cu-J1-Cu ….J2 … Cu-J1-Cu … magnetic chains. We found in the dimers weak antiferromagnetic exchange interactions J1/k = -5.9 (1) k and between them J2/k = -2.3 k.

  5. Spectroscopic and molecular modeling study on the interaction of ctDNA with 3′-deoxy-3′-azido doxorubicin

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Shaoguang; Cui, Yanrui; Liu, Qingfeng [School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007 (China); Cui, Fengling, E-mail: fenglingcui@hotmail.com [School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007 (China); Zhang, Guisheng; Chi, Yanwei [School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007 (China); Peng, Hao [School of Environment, Henan Normal University, Xinxiang 453007 (China)

    2013-09-15

    The method of synthesizing 3′-deoxy-3′-azido doxorubicin (ADOX) directly from doxorubicin has been developed. This study presents the interaction between ADOX and calf thymus deoxyribonucleic acid (ctDNA) by using spectroscopic methods and molecular modeling techniques. Iodide quenching, fluorescence polarization, viscosity and molecular modeling studies of ADOX–ctDNA interactions indicated that ADOX was an intercalator of ctDNA and preferentially bound to C–G rich regions of ctDNA. Simultaneously, spectroscopic results indicated that the quenching mechanism of ADOX–ctDNA was a static quenching. According to thermodynamic parameters, electrostatic force played roles in the interaction of ADOX with ctDNA. -- Highlights: ●An approach to 3′-deoxy-3′-azido doxorubicin (ADOX) from doxorubicin was developed. ●The quenching mechanism of ADOX with ctDNA was a static quenching type. ●The binding mode between ADOX and ctDNA was intercalative binding. ●The results of molecular docking corroborated results of spectra investigations.

  6. Mononuclear thiocyanate containing nickel(II) and binuclear azido bridged nickel(II) complexes of N4-coordinate pyrazole based ligand: Syntheses, structures and magnetic properties

    Science.gov (United States)

    Solanki, Ankita; Monfort, Montserrat; Kumar, Sujit Baran

    2013-10-01

    Two mononuclear nickel(II) complexes [NiL1(NCS)2] (1) and [NiL2(NCS)2] (2) and two azido bridged binuclear nickel(II) complexes [Ni(()2()2] (3) and [Ni(()2()2] (4), where L1, L2, L1‧ and L2‧ are N,N-diethyl-N‧,N‧-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine (L1), N,N-bis((1H-pyrazol-1-yl)methyl)-N‧,N‧-diethylethane-1,2-diamine (L2), N,N-diethyl-N‧-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)ethane-1,2-diamine (L1‧) and N-((1H-pyrazol-1-yl)methyl)-N‧,N‧-diethylethane-1,2-diamine (L2‧) have been synthesized and characterized by microanalyses and physico-chemical methods. Single crystal X-ray diffraction analyses revealed that complexes 1 and 2 are mononuclear NCS- containing Ni(II) complex with octahedral geometry and complexes 3 and 4 are end-on (μ-1,1) azido bridged binuclear Ni(II) complexes with distorted octahedral geometry. Variable temperature magnetic studies of the complexes 3 and 4 display ferromagnetic interaction with J values 19 and 32 cm-1, respectively.

  7. Synthesis and Crystal Structure of catena-Poly[[[2,4-dibromo-6-[(3-dimethylaminopropylimino)-methyl]phenolato]copper(Ⅱ)]-μ-azido

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A novel end-to-end azido-bridged polynuclear Schiff-base copper(H) complex,[Cu(C12H15Br2N2O)(N3)]n, was prepared and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction.The crystal belongs to the orthorhombic system, space group Pbcn with a = 24.588(5), b = 10.377(2), c = 13.022(3)(A),V= 3322.6(12)(A)3, Z = 8, Dc = 1.874 g/cm3, Mr= 468.65, λ(MoKα) = 0.71073 (A),μ= 6.130 mm-1, F(000) = 1832, R = 0.0637 and wR = 0.1176.The Cu atom in the complex is five-coordinated in a square pyramidal geometry by three donoratoms of the Schiff-base ligand, and two N atoms from two bridging azide ligands.The [2,4-dibromo-6-[(3-dimethylaminopropylimino)methyl]phenolato]copper(Ⅱ) units are linked by the bridging azide ligands, giving zigzag polymeric chains with backbones of the [-Cu-N-N-N-Cu]n type running along the b axis.

  8. Studies on yeast nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). IV. Steady-state kinetic properties with thymidine nucleotides (including 3'-azido-3'-deoxythymidine analogues).

    Science.gov (United States)

    Kuby, S A; Fleming, G; Alber, T; Richardson, D; Takenaka, H; Hamada, M

    1991-01-01

    A study of the steady-state kinetics of the crystalline brewer's yeast (Saccharomyces carlsbergensis) nucleoside diphosphokinase, with the magnesium complexes of the adenine and thymidine nucleotides as reactants, has led to a postulated kinetic mechanism which proceeds through a substituted enzyme. This agrees with the earlier conclusions of Garces and Cleland [Biochemistry 1969; 8:633-640] who characterized a reaction between the magnesium complexes of the adenine and uridine nucleotides. An advantage of using thymidine nucleotides as reactants is that they permit accurate, rapid and continuous assays of the enzymatic activity in coupled-enzymatic tests. Through measurements of the initial velocities and product inhibition studies, the Michaelis constants, maximum velocities, and inhibition constants could be evaluated for the individual substrates. Competitive substrate inhibition was encountered at relatively high substrate concentrations, which also permitted an evaluation of their ability to act as 'dead-end' inhibitors. The Michaelis constants for the 3'-azido-3'-deoxythymidine (AzT) analogues were also evaluated and, although these values were only somewhat higher than those of their natural substrates, the Km's for the adenine nucleotides as paired substrates were lower and the Vmax's were drastically reduced. The pharmacological implications of these observations are touched upon and extrapolated to the cases where therapeutic doses of AzT may be employed.

  9. A trial with 3'-azido-2',3'-dideoxythymidine and human interferon-α in cats naturally infected with feline leukaemia virus.

    Science.gov (United States)

    Stuetzer, Bianca; Brunner, Konstanze; Lutz, Hans; Hartmann, Katrin

    2013-08-01

    Feline leukaemia virus (FeLV) infection is still one of the leading causes of infection-related deaths in domestic cats. Treatment with various drugs has been attempted, but none has resulted in cure or complete virus elimination. Human interferon-α2a (huIFN-α2a) and 3'-azido-2',3'-dideoxythymidine (AZT) have been proven to decrease antigenaemia in cats infected experimentally with FeLV. The purpose of this study was to assess the efficacy of huIFN-α2a, AZT and a combination of both drugs in cats infected naturally with FeLV in a placebo-controlled double-blinded trial. Fourty-four FeLV-infected cats in which free FeLV p27 antigen was detected in serum by enzyme-linked immunosorbent assay were included in the study. Cats were assigned to one of four treatment groups that received either high dose huIFN-α2a (10(5) IU/kg q24h; 12 cats), AZT (5 mg/kg q12h; 10 cats, both of these treatments (12 cats) or placebo (10 cats). All cats were treated for 6 weeks. Clinical variables, including stomatitis, and laboratory parameters, such as CD4(+) and CD8(+) counts and serum FeLV p 27 antigen concentration, were recorded throughout the treatment period. No significant difference among the groups was observed during the treatment period for any of the parameters. Aside from anaemia in one cat treated with AZT, no adverse effects were observed. It was not possible to demonstrate efficacy of huIFN-α2a or AZT alone or together in cats infected naturally with FeLV when given according to this regimen for 6 weeks; however, no notable side effects were detected.

  10. Bis{bis(azido-κNbis[bis(pyridin-2-yl-κNamine]cobalt(III} sulfate dihydrate

    Directory of Open Access Journals (Sweden)

    Fatima Setifi

    2016-04-01

    Full Text Available The search for new molecular materials with interesting magnetic properties, using the pseudohalide azide ion and di-2-pyridylamine (dpa, C10H9N3 as a chelating ligand, led to the synthesis and structure determination of the title compound, [Co(N32(dpa2]2SO4·2H2O. The crystal structure comprises discrete [Co(dpa2(N32]+ cations, sulfate anions, as well as H2O solvent molecules. The CoIII cations display a slightly distorted octahedral coordination sphere defined by two N atoms from azide anions and four N atoms from the pyridyl rings of two dpa ligands. In the crystal, extensive C—H...O, N—H...O, and O—H...O interactions result in supramolecular sheets that lie parallel to the ab plane. The sheets are further linked through O—H...N interactions between the water molecules of one sheet and azide anions of another sheet, forming a supramolecular framework.

  11. Insecticidal quinazoline derivatives with (trifluoromethyl)diazirinyl and azido substituents as NADH:ubiquinone oxidoreductase inhibitors and candidate photoaffinity probes.

    Science.gov (United States)

    Latli, B; Wood, E; Casida, J E

    1996-03-01

    Two candidate photoaffinity probes are designed from 4-substituted quinazolines known to be potent insecticides/acaricides and NADH:ubiquinone oxidoreductase inhibitors acting at or near the rotenone site. 4-(11-Azidoundecyl-2-amino)quinazoline, based on the undecylamino analog SAN 548A as a prototype, was synthesized in 18% overall yield from ethyl 10-undecenoate by oxidation of the terminal double bond, reductive amination, coupling to 4-chloroquinazoline, and functional group manipulation of the terminal ethyl ester to an alcohol, a mesylate and finally nucleophilic displacement with azide ions. 4-(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenethoxy)quinaz oline [the (trifluoromethyl)diazirinyl analog of fenazaquin insecticide/acaricide] was prepared from 4-bromophenethyl alcohol in 31% overall yield by first introducing the trifluoromethylketone moiety followed by its conversion to the (trifluoromethyl)-diazirine and finally coupling to 4-chloroquinazoline as above. Both candidate photoaffinity probes have the inhibitory potency of rotenone (IC50 of 3-4 nM in each case). The azidoundecylamino compound has inadequate photoreactivity whereas that of the (trifluoromethyl)diazirinyl analog is ideal at 350 nm. Radiosynthesis of the latter photoaffinity ligand included introduction of the diazirinyl moiety as the carbene precursor, oxidation of (trifluoromethyl)diazirinylphenethyl alcohol to the corresponding acid with Jones' reagent, and reduction of the phenacetyl chloride intermediate with sodium borotritide to incorporate tritium.

  12. Polybenzimidazole compounds

    Science.gov (United States)

    Klaehn, John R.; Peterson, Eric S.; Wertsching, Alan K.; Orme, Christopher J.; Luther, Thomas A.; Jones, Michael G.

    2010-08-10

    A PBI compound that includes imidazole nitrogens, at least a portion of which are substituted with an organic-inorganic hybrid moiety. At least 85% of the imidazole nitrogens may be substituted. The organic-inorganic hybrid moiety may be an organosilane moiety, for example, (R)Me.sub.2SiCH.sub.2--, where R is selected from among methyl, phenyl, vinyl, and allyl. The PBI compound may exhibit similar thermal properties in comparison to the unsubstituted PBI. The PBI compound may exhibit a solubility in an organic solvent greater than the solubility of the unsubstituted PBI. The PBI compound may be included in separatory media. A substituted PBI synthesis method may include providing a parent PBI in a less than 5 wt % solvent solution. Substituting may occur at about room temperature and/or at about atmospheric pressure. Substituting may use at least five equivalents in relation to the imidazole nitrogens to be substituted or, preferably, about fifteen equivalents.

  13. 叠氮侧链支化NC的合成和表征%Synthesis and Properties of Azido-sidechain Branched NC

    Institute of Scientific and Technical Information of China (English)

    杨斐霏; 邵自强; 王飞俊; 王文俊; 张有德; 王慧庆

    2011-01-01

    In order to break the energy limitation of nitrocellulose(NC) and improve its low-temperature mechanical properties by decreasing the glass transition temperature, NC with azide side chains called PA-IPDI branching NC was synthesised. Via isophorone diisocyanate (IPDI) first reacted with residual hydroxyl on NC, and then reacted with the introduced 2,2-bis azido methyl 1 ,3-propanediol (PA). Its molecular structure, energy performance, thermal stability and dynamic mechanical properties of PA-IPDI branching NC were studied by IR, elemental analysis, TG, DSC and DMA, respectively. The results show that the released heat per mass unit of modified NC of 1466 J · G"' is nearly two times more than unmodified NC with 11. 75% N. The calculated value of heat of detonation of modified NC ( 4434 kJ · Kg-1) is higher than that of 1 · NC (4152 kJ · Kg-1). The glass transition temperature of modified NC (117.3 ℃) is lower than that of unmodified NC with 11. 75% N (140. 2 ℃), the tensile modulus of modified NC is higher than that of unmodified NC within ± 60 ℃. It is suggested that PA-IPDI modified NC is an excellent substitute of NC.%为突破硝化纤维素(NC)的能量限制,降低玻璃化温度以提高NC的低温力学性能,通过异佛尔酮二异氰酸酯(IPDI)与NC上残余的羟基反应,然后与2,2-二叠氮甲基-1,3-丙二醇(PA)反应,合成了一种叠氮侧链NC,称为支化NC的叠氮侧链NC(即PA-IPDI改性NC).用红外(IR)、元素分析、热重分析(TG)、差示扫描量热分析(DSC)和动态力学分析(DMA)等方法研究了产物的分子结构、能量性能、热稳定性及动态力学性能.结果表明,改性NC单位质量的放热量接近改性前NC(含氮量11.75%)的2倍,计算爆热为4434 kJ·kg-1,超过1#NC(4152 kJ·kg-1)的水平,改性后玻璃化转变温度(117.3 ℃)低于改性前NC(140.2℃),并且在±60℃范围内,改性NC的抗拉模量也高于改性前NC,认为PA-IPDI改性NC是一种性能优良的NC替代品.

  14. Synthesis, spectral characterization, thermal and photoluminescence properties of Zn(II) and Cd(II)-azido/thiocyanato complexes with thiazolylazo dye and 1,2-bis(diphenylphoshino)ethane.

    Science.gov (United States)

    Yamgar, B A; Sawant, V A; Bharate, B G; Chavan, S S

    2011-01-01

    A series of complexes of the type [M(L)(dppe)X2]; where M=Zn(II) or Cd(II); L=4-(2'-thiazolylazo)chlorobenzene (L1), 4-(2'-thiazolylazo)bromobenzene (L2) and 4-(2'-thiazolylazo) iodobenzene (L3); dppe=1,2-bis(diphenylphosphino)ethane; X=N3- or NCS- have been prepared and characterized on the basis of their microanalysis, molar conductance, thermal, IR, UV-vis and 1H NMR spectral studies. IR spectra show that the ligand L is coordinated to the metal atom in bidentate manner via azo nitrogen and thiazole nitrogen. An octahedral structure is proposed for all the complexes. The thermal behavior of the complexes revealed that the thiocyanato complexes are thermally more stable than the azido complexes. All the complexes exhibit blue-green emission with high quantum yield as the result of the fluorescence from the intraligand emission excited state.

  15. 5 prime -Azido-(3,6- sup 3 H sub 2 )-1-naphthylphthalamic acid, a photoactivatable probe for naphthylphthalamic acid receptor proteins from higher plants: Identification of a 23-kDa protein from maize coleoptile plasma membranes

    Energy Technology Data Exchange (ETDEWEB)

    Zettl, R.; Feldwisch, J.; Schell, J.; Palme, K. (Max-Planck-Inst. fuer Zuechtungsforschung, Koeln (West Germany)); Boland, W. (Univ. Karlsruhe (West Germany))

    1992-01-15

    1-Naphthylphthalamic acid (NPA) is a specific inhibitor of polar auxin transport that blocks carrier mediated auxin efflux from plant cells. To allow identification of the NPA receptor thought to be part of the auxin efflux carrier, the authors have synthesized a tritiated, photolabile NPA analogue, 5{prime}-azido-(3,6-{sup 3}H{sub 2})NPA (({sup 3}H{sub 2})N{sub 3}NPA). This analogue was used to identify NPA-binding proteins in fractions highly enriched for plasma membrane vesicles isolated from maize coleoptiles (Zea mays L.). Competition studies showed that binding of ({sup 3}H{sub 2})N{sub 3}NPA to maize plasma membrane vesicles was blocked by nonradioactive NPA but not by benzoic acid. After incubation of plasma membrane vesicles with ({sup 3}H{sub 2})N{sub 3}NPA and exposure to UV light, they observed specific photoaffinity labeling of a protein with an apparent molecular mass of 23 kDa. Pretreatment of the plasma membrane vesicles with indole-3-acetic acid or with the auxin-transport inhibitors NPA and 2,3,5-triiodobenzoic acid strongly reduced specific labeling of this protein. This 23-kDa protein was also labeled by addition of 5-azido-(7-{sup 3}H)indole-3-acetic acid to plasma membranes prior to exposure to UV light. The 23-kDa protein was solubilized from plasma membranes by 1% Triton X-100. The possibility that this 23-kDa polypeptide is part of the auxin efflux carrier system is discussed.

  16. Multipurpose Compound

    Science.gov (United States)

    1983-01-01

    Specially formulated derivatives of an unusual basic compound known as Alcide may be the answer to effective treatment and prevention of the disease bovine mastitis, a bacterial inflammation of a cow's mammary gland that results in loss of milk production and in extreme cases, death. Manufactured by Alcide Corporation the Alcide compound has killed all tested bacteria, virus and fungi, shortly after contact, with minimal toxic effects on humans or animals. Alcide Corporation credits the existence of the mastitis treatment/prevention products to assistance provided the company by NERAC, Inc.

  17. Looking for high energy density compounds applicable for propellant among the derivatives of DPO with -N3, -ONO2, and -NNO2 groups.

    Science.gov (United States)

    Wang, Gui-Xiang; Gong, Xue-Dong; Liu, Yan; Du, Hong-Chen; Xu, Xiao-Juan; Xiao, He-Ming

    2011-04-15

    The derivatives of DPO (2,5-dipicryl-1,3,4-oxadiazole) are optimized to obtain their molecular geometries and electronic structures at the DFT-B3LYP/6-31G* level. The bond length is focused to primarily predict thermal stability and the pyrolysis mechanism of the title compounds. Detonation properties are evaluated using the modified Kamlet-Jacobs equations based on the calculated densities and heats of formation. It is found that there are good linear relationships between density, detonation velocity, detonation pressure, and the number of azido, nitrate, and nitramine groups. According to the largest exothermic principle, the relative specific impulse is investigated by calculating the enthalpy of combustion (ΔH(comb)) and the total heat capacity (C(p,gases)). It is found that the introduction of -N(3), -ONO(2), and -NNO(2) groups could increase the specific impulses and II-4, II-5, and III-5 are potential candidates for High Energy Density Materials (HEDMs). The effect of the azido, nitrate, and nitramine groups on the structure and the properties is discussed.

  18. Intermetallic Compounds

    Science.gov (United States)

    Takagiwa, Y.; Matsuura, Y.; Kimura, K.

    2014-06-01

    We have focused on the binary narrow-bandgap intermetallic compounds FeGa3 and RuGa3 as thermoelectric materials. Their crystal structure is FeGa3-type (tetragonal, P42/ mnm) with 16 atoms per unit cell. Despite their simple crystal structure, their room temperature thermal conductivity is in the range 4-5-W-m-1-K-1. Both compounds have narrow-bandgaps of approximately 0.3-eV near the Fermi level. Because their Seebeck coefficients are quite large negative values in the range 350-FeGa3 and RuGa3 as n and p-type materials. The dimensionless figure of merit, ZT, was significantly improved by substitution of Sn for Ga in FeGa3 (electron-doping) and by substitution of Zn for Ga in RuGa3 (hole-doping), mainly as a result of optimization of the electronic part, S 2 σ.

  19. Compound odontoma

    Directory of Open Access Journals (Sweden)

    Monica Yadav

    2012-01-01

    Full Text Available Odontomas have been extensively reported in the dental literature, and the term refers to tumors of odontogenic origin. Though the exact etiology is still unknown, the postulated causes include: local trauma, infection, inheritance and genetic mutation. The majority of the lesions are asymptomatic; however, may be accompanied with pain and swelling as secondary complaints in some cases. Here, we report a case of a compound odontome in a 14 year old patient.

  20. Organic Compounds

    Science.gov (United States)

    Shankland, Kenneth

    For many years, powder X-ray diffraction was used primarily as a fingerprinting method for phase identification in the context of molecular organic materials. In the early 1990s, with only a few notable exceptions, structures of even moderate complexity were not solvable from PXRD data alone. Global optimisation methods and highly-modified direct methods have transformed this situation by specifically exploiting some well-known properties of molecular compounds. This chapter will consider some of these properties.

  1. Magnesium compounds

    Science.gov (United States)

    Kramer, D.A.

    2012-01-01

    Seawater and natural brines accounted for about 57 percent of magnesium compounds produced in the United States in 2011. Dead-burned magnesia was produced by Martin Marietta Magnesia Specialties LLC from well brines in Michigan. Caustic-calcined magnesia was recovered from seawater by Premier Magnesia LLC in Florida, from well brines in Michigan by Martin Marietta and from magnesite in Nevada by Premier Magnesia. Intrepid Potash Wendover LLC and Great Salt Lake Minerals Corp. recovered magnesium chloride brines from the Great Salt Lake in Utah. Magnesium hydroxide was produced from seawater by SPI Pharma Inc. in Delaware and Premier Magnesia in Florida, and by Martin Marietta from its brine operation in Michigan.

  2. The Calculation of Bond Dissociation Energies for Azide Group in Some Azido Compounds%对一些叠氮化合物的叠氮自由基键离解能的计算

    Institute of Scientific and Technical Information of China (English)

    邵菊香; 程新路; 杨向东; 葛素红

    2007-01-01

    用4个高精度的完全基组CBS(CBS-Q,CBS-QB3,CBS-Lq和CBS-4M),B3LYP/6-311G**,B3LYP/6-311+G**和MP2配合6-311G**与6-31+G**等多个不同大小的基组的计算方法,对HN3、CH3N3、C2H5N3、NCN3、C2H3N3和NH2CH2N3中离解掉叠氮自由基(·N3)时的键离解能进行计算.将计算的键离解能与实验值进行比较,发现B3LYP和4种完全基组计算方法都不能为这些叠氮化合物计算出满意的键离解能,而MP2方法,尤其配合6-31+G**基组时,能够计算出与实验值吻合得很好的R-N3键离解能.因此,当计算这些中小型叠氮化合物中离解掉叠氮基的键离解能时,用MP2/6-31+G**是一种可靠的计算方法.

  3. Arene ruthenium(II) azido complexes incorporating N intersection O chelate ligands: Synthesis, spectral studies and 1,3-dipolar-cycloaddition to a coordinated azide in ruthenium(II) compounds

    Digital Repository Service at National Institute of Oceanography (India)

    Singh, K.S.; Kaminsky, W.

    (Arrora Matthey), L-proline, glycine, dimethylacetylene dicarboxylate (DMD), diethylacetylene 3    dicarboxylate (DED) and sodium azide (Sigma Aldrich), were used as received. NMR spectra were recorded on a Bruker Avance 300 MHz spectrometer at 300.13 (1...

  4. Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.

    Science.gov (United States)

    Lapinsky, David J; Velagaleti, Ranganadh; Yarravarapu, Nageswari; Liu, Yi; Huang, Yurong; Surratt, Christopher K; Lever, John R; Foster, James D; Acharya, Rejwi; Vaughan, Roxanne A; Deutsch, Howard M

    2011-01-01

    In contrast to tropane-based compounds such as benztropine and cocaine, non-tropane-based photoaffinity ligands for the dopamine transporter (DAT) are relatively unexplored. Towards addressing this knowledge gap, ligands were synthesized in which the piperidine nitrogen of 3- and 4-iodomethylphenidate was substituted with a benzyl group bearing a photoreactive azide. Analog (±)-3a demonstrated modest DAT affinity and a radioiodinated version was shown to bind covalently to rat striatal DAT and hDAT expressed in cultured cells. Co-incubation of (±)-3a with nonradioactive d-(+)-methylphenidate or (-)-2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (β-CFT, WIN-35,428, a cocaine analog) blocked DAT labeling. Compound (±)-3a represents the first successful example of a DAT photoaffinity ligand based on the methylphenidate scaffold. Such ligands are expected to assist in mapping non-tropane ligand-binding pockets within plasma membrane monoamine transporters.

  5. Self-assembly of linear [Mn II 2 Mn III ] units with end-on azido bridges: the construction of a ferromagnetic chain using S T = 7 high-spin trimers

    KAUST Repository

    Jiang, Yuan

    2015-01-01

    © The Royal Society of Chemistry 2015. The controlled organization of high-spin complexes into 1D coordination polymers is a challenge in molecular magnetism. In this work, we report a ferromagnetic Mn trimer Mn3(HL)2(CH3OH)6(Br)4·Br·(CH3OH)21 (H2L = 2-[(9H-fluoren-9-yl)amino]propane-1,3-diol) with the ground spin state of ST = 7 that can be assembled into a one-dimensional coordination chain [Mn3(HL)2(CH3OH)2(Br)4(N3)(H2O)·CH3OH]2 using azido bridging ligands. Interestingly, the ferromagnetic nature of 1 is well retained in 2. However, due to the negligible magnetic anisotropy in 1, both 1 and 2 do not show slow-relaxation of magnetization, which indicates that during the process of molecular assembly not only the intratrimer magnetic interaction but also the magnetic anisotropy of the trimer can be reserved.

  6. Preparation of a poly(3'-azido-3'-deoxythymidine-co-propargyl methacrylate-co-pentaerythritol triacrylate) monolithic column by in situ polymerization and a click reaction for capillary liquid chromatography of small molecules and proteins.

    Science.gov (United States)

    Lin, Zian; Yu, Ruifang; Hu, Wenli; Zheng, Jiangnan; Tong, Ping; Zhao, Hongzhi; Cai, Zongwei

    2015-07-01

    Combining free radical polymerization with click chemistry via a copper-mediated azide/alkyne cycloaddition (CuAAC) reaction in a "one-pot" process, a facile approach was developed for the preparation of a poly(3'-azido-3'-deoxythymidine-co-propargyl methacrylate-co-pentaerythritol triacrylate) (AZT-co-PMA-co-PETA) monolithic column. The resulting poly(AZT-co-PMA-co-PETA) monolith showed a relatively homogeneous monolithic structure, good permeability and mechanical stability. Different ratios of monomers and porogens were used for optimizing the properties of a monolithic column. A series of alkylbenzenes, amides, anilines, and benzoic acids were used to evaluate the chromatographic properties of the polymer monolith in terms of hydrophobic, hydrophilic and cation-exchange interactions, and the results showed that the poly(AZT-co-PMA-co-PETA) monolith exhibited more flexible adjustment in chromatographic selectivity than that of the parent poly(PMA-co-PETA) and AZT-modified poly(PMA-co-PETA) monoliths. Column efficiencies for toluene, DMF, and formamide with 35,000-48,000 theoretical plates per m could be obtained at a linear velocity of 0.17 mm s(-1). The run-to-run, column-to-column, and batch-to-batch repeatabilities of the retention factors were less than 4.2%. In addition, the proposed monolith was also applied to efficient separation of sulfonamides, nucleobases and nucleosides, anesthetics and proteins for demonstrating its potential.

  7. New water-soluble azido- and derived tetrazolato-platinum(II) complexes with PTA. Easy metal-mediated synthesis and isolation of 5-substituted tetrazoles.

    Science.gov (United States)

    Smoleński, Piotr; Mukhopadhyay, Suman; Guedes da Silva, M Fátima C; Charmier, M Adília Januário; Pombeiro, Armando J L

    2008-12-14

    The water-soluble four- and five-coordinate diazido-platinum(II) complexes cis-[Pt(N3)2(PTA)2] (1) (PTA = 1,3,5-triaza-7-phosphaadamantane), cis-[Pt(N3)2(Me-PTA)2]I2 (2) (Me-PTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation) and [Pt(N3)2(PTA)3] (3) were obtained by reactions of cis-[Pt(N3)2(PPh3)2] with PTA or [Me-PTA]I in dichloromethane. [2 + 3] cycloadditions of with organonitriles NCR gave the bis(tetrazolato) complexes trans-[Pt(N4CR)2(PTA)2] (R = Ph (4), 4-ClC6H4 (5) or 3-NC5H4 (6)), the reactions being greatly accelerated by microwave irradiation. 5-R-1H-Tetrazoles N4CR (R = Ph, 4-ClC6H4 and 3-NC5H4) were easily liberated from the tetrazolato complexes and isolated in high yields, in a single-pot process, upon reaction with aqueous diluted HCl, with concomitant formation of the water soluble cis-[Pt(Cl)2(PTA-H)2] complex 7. Alternatively, in a less convenient method, the tetrazoles could be liberated on reaction of 4-6 with propionitrile which also leads to the dicyano trans-[Pt(CN)2(PTA)2] complex 8. The compounds were characterized by IR, 1H, 13C and 31P[1H] NMR spectroscopies, FAB+-MS or ESI-MS, elemental analyses and (for and 4) also by X-ray diffraction.

  8. Volatile Organic Compounds (VOCs)

    Science.gov (United States)

    ... Share Facebook Twitter Google+ Pinterest Contact Us Volatile Organic Compounds' Impact on Indoor Air Quality On this ... Exposure Standards or Guidelines Additional Resources Introduction Volatile organic compounds (VOCs) are emitted as gases from certain ...

  9. Reissert compound of bisbenzimidazole

    OpenAIRE

    1989-01-01

    A Reissert compound of bisbenzimidazole can be formed by first reacting benzimidazole with an aliphatic diacid chloride to form bisbenzimidazole and then reacting the bisbenzimidazole with an aliphatic acid chloride and cyanide to form the Reissert compound thereof.

  10. Structure and reactivity of a pyridine-1-imido-2-thiolato complex of iridium(III), CpIr(1-N-2-Spy), generated by photolysis of the (azido)(pyridine-2-thiolato) complex, CpIr(2-Spy)(N3).

    Science.gov (United States)

    Sekioka, Yusuke; Kaizaki, Sumio; Mayer, James M; Suzuki, Takayoshi

    2005-11-14

    Photolysis of the (azido)(pyridine-2-thiolato)iridium(III) complex CpIr(2-Spy)(N3) (1) gave a pyridine-1-imido-2-thiolato complex, CpIr(1-N-2-Spy) (2), in which one of the nitrogen atoms of the azide ligand has been inserted into the Ir-N(py) bond (Cp = eta5-C5Me5). Complex 2 reacted quantitatively with methyl iodide to give the N-methylated product, [CpIr(1-NMe-2-Spy)]I (3). X-ray crystallography revealed that both 2 and 3 have similar two-legged piano stool structures with planar 1-N-2-Spy2- or 1-NMe-2-Spy- ligands, which form iridacyclopentadienyl-like rings by moderate S(ppi)/N(ppi) to Ir(dpi) pi donation.

  11. Ecotoxicology of organofluorous compounds.

    Science.gov (United States)

    Murphy, Margaret B; Loi, Eva I H; Kwok, Karen Y; Lam, Paul K S

    2012-01-01

    Organofluorous compounds have been developed for myriad purposes in a variety of fields, including manufacturing, industry, agriculture, and medicine. The widespread use and application of these compounds has led to increasing concern about their potential ecological toxicity, particularly because of the stability of the C-F bond, which can result in chemical persistence in the environment. This chapter reviews the chemical properties and ecotoxicology of four groups of organofluorous compounds: fluorinated refrigerants and propellants, per- and polyfluorinated compounds (PFCs), fluorinated pesticides, and fluoroquinolone antibiotics. These groups vary in their environmental fate and partitioning, but each raises concern in terms of ecological risk on both the regional and global scale, particularly those compounds with long environmental half-lives. Further research on the occurrence and toxicities of many of these compounds is needed for a more comprehensive understanding of their ecological effects.

  12. Determination of phenolic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Chao, G.K.J.; Suatoni, J.C.

    1982-01-01

    Details are given of a procedure for separation and identification of phenolic compounds in aqueous solution by high-performance liquid chromatography. It can also be applied to non-aqueous samples after preliminary isolation of a polar fraction containing the phenolic compounds.

  13. NATURAL POLYACETYLENE COMPOUNDS

    Directory of Open Access Journals (Sweden)

    D. A. Konovalov

    2014-01-01

    Full Text Available Polyacetylenes (polyynes are compounds which contain two or more triple bonds in its structure. About 2 000 different polyacetylenes and biogenetically related substances were identified in 24 families of higher plants. However, most of these compounds were found in seven families of flowering plants: Apiaceae (Umbelliferae, Araliaceae, Asteraceae (Compositae, Campanulaceae, Olacaceae, Pittosporaceae and Santalaceae. Polyacetylenes are relatively unstable, chemically and biologically active compounds, and present in fungi, microorganisms, marine invertebrates and other organisms except for plants. Acetylenes form distinct specialized group of chemically active natural compounds, which are biosynthesized in plants of unsaturated fatty acids. In addition to widespread aliphatic polyacetylenes thiophenes dithiacyclohexadienes (thiarubrines, thioethers, sulphoxides, sulphones, alkamides, chlorohydrins, lactones, spiroacetal enol ethers, furans, pyrans, tetrahydropyrans, isocoumarins, aromatic acetylenes were also found in plant species. Polyacetylenes are localized in different plant organs, and can be found both individually and as a compound with carbohydrates, terpene, phenolic and other compounds. Many polyacetylenes are found in the composition of the essential oils of plants and it confirms their strongly marked ecological functions. From biological point of view these compounds are often synthesized by plants as toxic or bitter antifeedants, allelopathic compounds, phytoalexins or broadly antibiotic components. Polyynes are strong photosensitizers. They exhibit anti-inflammatory, anti-coagulant, anti-bacterial, antituberculosis, anti-fungal, anti-viral, neuroprotective and neurotoxic activity. Immunostimulatory influence associated with certain allergenicity of some of these substances was established. Therefore, without a doubt polyacetylenes are of interest for the modern pharmacy and medicine.

  14. Heart testing compound

    Science.gov (United States)

    Knapp, F.F. Jr.; Goodman, M.M.

    1983-06-29

    The compound 15-(p-(/sup 125/I)-iodophenyl)-6-tellurapentadecanoic acid is disclosed as a myocardial imaging agent having rapid and pronounced uptake, prolonged myocardial retention, and low in vivo deiodination.

  15. Compound Semiconductor Radiation Detectors

    CERN Document Server

    Owens, Alan

    2012-01-01

    Although elemental semiconductors such as silicon and germanium are standard for energy dispersive spectroscopy in the laboratory, their use for an increasing range of applications is becoming marginalized by their physical limitations, namely the need for ancillary cooling, their modest stopping powers, and radiation intolerance. Compound semiconductors, on the other hand, encompass such a wide range of physical and electronic properties that they have become viable competitors in a number of applications. Compound Semiconductor Radiation Detectors is a consolidated source of information on all aspects of the use of compound semiconductors for radiation detection and measurement. Serious Competitors to Germanium and Silicon Radiation Detectors Wide-gap compound semiconductors offer the ability to operate in a range of hostile thermal and radiation environments while still maintaining sub-keV spectral resolution at X-ray wavelengths. Narrow-gap materials offer the potential of exceeding the spectral resolutio...

  16. Compound composite odontoma.

    Science.gov (United States)

    Girish, G; Bavle, Radhika M; Singh, Manish Kumar; Prasad, Sahana N

    2016-01-01

    The term odontoma has been used as a descriptor for any tumor of odontogenic origin. It is a growth in which both epithelial and mesenchymal cells exhibits complete differentiation. Odontomas are considered as hamartomas rather than true neoplasm. They are usually discovered on routine radiographic examination. Odontomas, according to the World Health Organization, are classified into complex odontoma and compound odontomas. The present paper reports a case of compound composite odontomas.

  17. Compound composite odontoma

    Directory of Open Access Journals (Sweden)

    G Girish

    2016-01-01

    Full Text Available The term odontoma has been used as a descriptor for any tumor of odontogenic origin. It is a growth in which both epithelial and mesenchymal cells exhibits complete differentiation. Odontomas are considered as hamartomas rather than true neoplasm. They are usually discovered on routine radiographic examination. Odontomas, according to the World Health Organization, are classified into complex odontoma and compound odontomas. The present paper reports a case of compound composite odontomas.

  18. Chemistry of peroxide compounds

    Science.gov (United States)

    Volnov, I. I.

    1981-01-01

    The history of Soviet research from 1866 to 1967 on peroxide compounds is reviewed. This research dealt mainly with peroxide kinetics, reactivity and characteristics, peroxide production processes, and more recently with superoxides and ozonides and emphasis on the higher oxides of group 1 and 2 elements. Solid state fluidized bed synthesis and production of high purity products based on the relative solubilities of the initial, intermediate, and final compounds and elements in liquid ammonia are discussed.

  19. Phenolic Molding Compounds

    Science.gov (United States)

    Koizumi, Koji; Charles, Ted; de Keyser, Hendrik

    Phenolic Molding Compounds continue to exhibit well balanced properties such as heat resistance, chemical resistance, dimensional stability, and creep resistance. They are widely applied in electrical, appliance, small engine, commutator, and automotive applications. As the focus of the automotive industry is weight reduction for greater fuel efficiency, phenolic molding compounds become appealing alternatives to metals. Current market volumes and trends, formulation components and its impact on properties, and a review of common manufacturing methods are presented. Molding processes as well as unique advanced techniques such as high temperature molding, live sprue, and injection/compression technique provide additional benefits in improving the performance characterisitics of phenolic molding compounds. Of special interest are descriptions of some of the latest innovations in automotive components, such as the phenolic intake manifold and valve block for dual clutch transmissions. The chapter also characterizes the most recent developments in new materials, including long glass phenolic molding compounds and carbon fiber reinforced phenolic molding compounds exhibiting a 10-20-fold increase in Charpy impact strength when compared to short fiber filled materials. The role of fatigue testing and fatigue fracture behavior presents some insight into long-term reliability and durability of glass-filled phenolic molding compounds. A section on new technology outlines the important factors to consider in modeling phenolic parts by finite element analysis and flow simulation.

  20. Highly trifluoromethylated platinum compounds.

    Science.gov (United States)

    Martínez-Salvador, Sonia; Forniés, Juan; Martín, Antonio; Menjón, Babil

    2011-07-11

    The homoleptic, square-planar organoplatinum(II) compound [NBu(4)](2) [Pt(CF(3))(4)] (1) undergoes oxidative addition of CF(3) I under mild conditions to give rise to the octahedral organoplatinum(IV) complex [NBu(4)](2) [Pt(CF(3))(5)I] (2). This highly trifluoromethylated species reacts with Ag(+) salts of weakly coordinating anions in Me(2)CO under a wet-air stream to afford the aquo derivative [NBu(4)][Pt(CF(3))(5) (OH(2))] (4) in around 75% yield. When the reaction of 2 with the same Ag(+) salts is carried out in MeCN, the solvento compound [NBu(4) ][Pt(CF(3))(5)(NCMe)] (5) is obtained in around 80% yield. The aquo ligand in 4 as well as the MeCN ligand in 5 are labile and can be cleanly replaced by neutral and anionic ligands to furnish a series of pentakis(trifluoromethyl)platinate(IV) compounds with formulae [NBu(4)][Pt(CF(3))(5) (L)] (L=CO (6), pyridine (py; 7), tetrahydrothiophene (tht; 8)) and [NBu(4)](2) [Pt(CF(3))(5)X] (X=Cl (9), Br (10)). The unusual carbonyl-platinum(IV) derivative [NBu(4)][Pt(CF(3))(5) (CO)] (6) is thermally stable and has a ν(CO) of 2194 cm(-1). The crystal structures of 2⋅CH(2)Cl(2), 5, [PPh(4) ][Pt(CF(3))(5)(CO)] (6'), and 7 have been established by X-ray diffraction methods. Compound 2 has shown itself to be a convenient entry to the chemistry of highly trifluoromethylated platinum compounds. To the best of our knowledge, compounds 2 and 4-10 are the organoelement compounds with the highest CF(3) content to have been isolated and adequately characterized to date.

  1. Compound semiconductor device physics

    CERN Document Server

    Tiwari, Sandip

    2013-01-01

    This book provides one of the most rigorous treatments of compound semiconductor device physics yet published. A complete understanding of modern devices requires a working knowledge of low-dimensional physics, the use of statistical methods, and the use of one-, two-, and three-dimensional analytical and numerical analysis techniques. With its systematic and detailed**discussion of these topics, this book is ideal for both the researcher and the student. Although the emphasis of this text is on compound semiconductor devices, many of the principles discussed will also be useful to those inter

  2. Fun with Ionic Compounds

    Science.gov (United States)

    Logerwell, Mollianne G.; Sterling, Donna R.

    2007-01-01

    Ionic bonding is a fundamental topic in high school chemistry, yet it continues to be a concept that students struggle to understand. Even if they understand atomic structure and ion formation, it can be difficult for students to visualize how ions fit together to form compounds. This article describes several engaging activities that help…

  3. Computing compound distributions faster

    NARCIS (Netherlands)

    P. den Iseger; M.A.J. Smith; R. Dekker (Rommert)

    1997-01-01

    textabstractThe use of Panjer's algorithm has meanwhile become a widespread standard technique for actuaries (Kuon et al., 1955). Panjer's recursion formula is used for the evaluation of compound distributions and can be applied to life and general insurance problems. The discrete version of Panjer'

  4. Aminopropyl thiophene compounds

    Science.gov (United States)

    Goodman, Mark M.; Knapp, Jr., Furn F.

    1990-01-01

    Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.

  5. NATURAL POLYACETYLENE COMPOUNDS

    Directory of Open Access Journals (Sweden)

    A. M. Nasukhova

    2014-01-01

    Full Text Available In article the review of the initial stage of researches of natural polyacetylene compounds is resulted. The high reactionary ability leading to fast oxidation and degradation of these compounds, especially at influence of Uf-light, oxygen of air, pH and other factors, has caused the serious difficulties connected with an establishment of structure and studying of their physical and chemical properties. Therefore the greatest quantity of works of this stage is connected with studying of essential oils of plants from families Apiaceae, Araliaceae, Asteraceae, Campanulaceae, Olacaceae, Pittosporaceae and Santalaceae where have been found out, basically, diacetylene compounds. About development of physical and chemical methods of the analysis of possibility of similar researches have considerably extended. More than 2000 polyacetylenes are known today, from them more than 1100 are found out in plants fam. Asteraceae. Revolution in the field of molecular biology has allowed to study processes of biosynthesis of these compounds intensively.

  6. Flavour Compounds in Fungi

    DEFF Research Database (Denmark)

    Ravasio, Davide Antonio

    Fungi produce a variety of volatile organic compounds (VOCs) during their primary or secondary metabolism and with a wide range of functions. The main focus of this research work has been put on flavour molecules that are produced during fermentation processes, mainly esters and alcohols derived...

  7. Toxicity of dipyridyl compounds and related compounds.

    Science.gov (United States)

    Li, Shenggang; Crooks, Peter A; Wei, Xiaochen; de Leon, Jose

    2004-01-01

    Five dipyridyl isomers, 2,2'-, 2,3'-, 2,4'-, 3,3'-, and 4,4'-dipyridyl, are products resulting from the pyrolytic degradation of tobacco products and degradation of the herbicide paraquat, and therefore may be present in the environment. In this article, the toxicological properties of these dipyridyl isomers in humans and animals are reviewed. Epidemiological studies suggest that cancerous skin lesions in workers involved in the manufacturing of paraquat may be associated with exposure to dipyridyl compounds. Experimental animal studies suggest that dipyridyl isomers may have several toxicological effects. Three of the dipyridyl isomers (the 2,2', 2,4', and 4,4' isomers) appear to be inducers of some metabolic enzymes. The 2,2'-dipyridyl isomer, an iron chelator, appears to influence vasospasm in primate models of stroke. The cytotoxic effects of 2,2'-dipyridyl on several leukemia cell lines have been reported, and a potent teratogenic effect of 2,2'-dipyridyl has been observed in rats. Based on the results of paraquat studies in experimental animal models, it has been proposed that paraquat may have deleterious effects on dopaminergic neurons. These findings support the epidemiological evidence that paraquat exposure may be associated with the development of Parkinson's disease. Studies designed to determine an association between paraquat exposure and Parkinson's disease are complicated by the possibility that metabolic changes may influence the neurotoxicity of paraquat and/or its metabolites. Preliminary unpublished data in mice show that 300-mg/kg doses of 2,2'-dipyridyl are neurotoxic, and 300-mg/kg doses of 2,4'- and 4,4'-dipyridyls are lethal. These results are consistent with earlier studies in Sherman rats using high 2,2'- and 4,4'-dipyridyl doses. New studies are needed to further explore the toxicological properties of dipyridyls and their potential public health impact.

  8. Compound semiconductor device modelling

    CERN Document Server

    Miles, Robert

    1993-01-01

    Compound semiconductor devices form the foundation of solid-state microwave and optoelectronic technologies used in many modern communication systems. In common with their low frequency counterparts, these devices are often represented using equivalent circuit models, but it is often necessary to resort to physical models in order to gain insight into the detailed operation of compound semiconductor devices. Many of the earliest physical models were indeed developed to understand the 'unusual' phenomena which occur at high frequencies. Such was the case with the Gunn and IMPATI diodes, which led to an increased interest in using numerical simulation methods. Contemporary devices often have feature sizes so small that they no longer operate within the familiar traditional framework, and hot electron or even quantum­ mechanical models are required. The need for accurate and efficient models suitable for computer aided design has increased with the demand for a wider range of integrated devices for operation at...

  9. Erupted compound odontome

    Directory of Open Access Journals (Sweden)

    Shekar S

    2009-01-01

    Full Text Available Odontomas are considered to be hamartomas rather than a true neoplasm. They consist chiefly of enamel and dentin, with variable amount of pulp and cementum when fully developed. They are generally asymptomatic and are included under the benign calcified odontogenic tumors. They are usually discovered on routine radiographic examination. Eruption of an odontoma in the oral cavity is rare. Peripheral compound odontomas arise extraosseously and have a tendency to exfoliate. In this article we are reporting a case of a 15-year-old girl with peripheral compound odontoma, with a single rudimentary tooth-like structure in the mandibular right second molar region, which is about to be exfoliated. Its eruption in the oral cavity and location in the mandibular posterior region is associated with aplasia of the mandibular right second molar, making it an interesting case for reporting.

  10. Process for compound transformation

    KAUST Repository

    Basset, Jean-Marie

    2016-12-29

    Embodiments of the present disclosure provide for methods of using a catalytic system to chemically transform a compound (e.g., a hydrocarbon). In an embodiment, the method does not employ grafting the catalyst prior to catalysis. In particular, embodiments of the present disclosure provide for a process of hydrocarbon (e.g., C1 to C20 hydrocarbon) metathesis (e.g., alkane, olefin, or alkyne metathesis) transformation, where the process can be conducted without employing grafting prior to catalysis.

  11. atmospheric volatile organic compounds

    Directory of Open Access Journals (Sweden)

    A. R. Koss

    2016-07-01

    organic compounds (VOCs that cannot be ionized with H3O+ ions (e.g., in a PTR-MS or H3O+ CIMS instrument. Here we describe the adaptation of a high-resolution time-of-flight H3O+ CIMS instrument to use NO+ primary ion chemistry. We evaluate the NO+ technique with respect to compound specificity, sensitivity, and VOC species measured compared to H3O+. The evaluation is established by a series of experiments including laboratory investigation using a gas-chromatography (GC interface, in situ measurement of urban air using a GC interface, and direct in situ measurement of urban air. The main findings are that (1 NO+ is useful for isomerically resolved measurements of carbonyl species; (2 NO+ can achieve sensitive detection of small (C4–C8 branched alkanes but is not unambiguous for most; and (3 compound-specific measurement of some alkanes, especially isopentane, methylpentane, and high-mass (C12–C15 n-alkanes, is possible with NO+. We also demonstrate fast in situ chemically specific measurements of C12 to C15 alkanes in ambient air.

  12. Toxicity of platinum compounds.

    Science.gov (United States)

    Hartmann, Jörg Thomas; Lipp, Hans-Peter

    2003-06-01

    Since the introduction of platinum-based combination chemotherapy, particularly cisplatin, the outcome of the treatment of many solid tumours has changed. The leading platinum compounds in cancer chemotherapy are cisplatin, carboplatin and oxaliplatin. They share some structural similarities; however, there are marked differences between them in therapeutic use, pharmacokinetics and adverse effects profiles [1-4]. Compared to cisplatin, carboplatin has inferior efficacy in germ-cell tumour, head and neck cancer and bladder and oesophageal carcinoma, whereas both drugs seem to have comparable efficacy in advanced non-small cell and small cell lung cancer as well as ovarian cancer [5-7]. Oxaliplatin belongs to the group of diaminocyclohexane platinum compounds. It is the first platinum-based drug that has marked efficacy in colorectal cancer when given in combination with 5-fluorouracil and folinic acid [8,9]. Other platinum compounds such as oral JM216, ZD0473, BBR3464 and SPI-77, which is a pegylated liposomal formulation of cisplatin, are still under investigation [10-13], whereas nedaplatin has been approved in Japan for the treatment of non-small cell lung cancer and other solid tumours. This review focuses on cisplatin, carboplatin and oxaliplatin.

  13. Antifungal compounds from cyanobacteria.

    Science.gov (United States)

    Shishido, Tânia K; Humisto, Anu; Jokela, Jouni; Liu, Liwei; Wahlsten, Matti; Tamrakar, Anisha; Fewer, David P; Permi, Perttu; Andreote, Ana P D; Fiore, Marli F; Sivonen, Kaarina

    2015-04-13

    Cyanobacteria are photosynthetic prokaryotes found in a range of environments. They are infamous for the production of toxins, as well as bioactive compounds, which exhibit anticancer, antimicrobial and protease inhibition activities. Cyanobacteria produce a broad range of antifungals belonging to structural classes, such as peptides, polyketides and alkaloids. Here, we tested cyanobacteria from a wide variety of environments for antifungal activity. The potent antifungal macrolide scytophycin was detected in Anabaena sp. HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description of Anabaena strains that produce scytophycins. We detected antifungal glycolipopeptide hassallidin production in Anabaena spp. BIR JV1 and HAN7/1 and in Nostoc spp. 6sf Calc and CENA 219. These strains were isolated from brackish and freshwater samples collected in Brazil, the Czech Republic and Finland. In addition, three cyanobacterial strains, Fischerella sp. CENA 298, Scytonema hofmanni PCC 7110 and Nostoc sp. N107.3, produced unidentified antifungal compounds that warrant further characterization. Interestingly, all of the strains shown to produce antifungal compounds in this study belong to Nostocales or Stigonematales cyanobacterial orders.

  14. Toxic compounds in honey.

    Science.gov (United States)

    Islam, Md Nazmul; Khalil, Md Ibrahim; Islam, Md Asiful; Gan, Siew Hua

    2014-07-01

    There is a wealth of information about the nutritional and medicinal properties of honey. However, honey may contain compounds that may lead to toxicity. A compound not naturally present in honey, named 5-hydroxymethylfurfural (HMF), may be formed during the heating or preservation processes of honey. HMF has gained much interest, as it is commonly detected in honey samples, especially samples that have been stored for a long time. HMF is a compound that may be mutagenic, carcinogenic and cytotoxic. It has also been reported that honey can be contaminated with heavy metals such as lead, arsenic, mercury and cadmium. Honey produced from the nectar of Rhododendron ponticum contains alkaloids that can be poisonous to humans, while honey collected from Andromeda flowers contains grayanotoxins, which can cause paralysis of limbs in humans and eventually leads to death. In addition, Melicope ternata and Coriaria arborea from New Zealand produce toxic honey that can be fatal. There are reports that honey is not safe to be consumed when it is collected from Datura plants (from Mexico and Hungary), belladonna flowers and Hyoscamus niger plants (from Hungary), Serjania lethalis (from Brazil), Gelsemium sempervirens (from the American Southwest), Kalmia latifolia, Tripetalia paniculata and Ledum palustre. Although the symptoms of poisoning due to honey consumption may differ depending on the source of toxins, most common symptoms generally include dizziness, nausea, vomiting, convulsions, headache, palpitations or even death. It has been suggested that honey should not be considered a completely safe food.

  15. Light metal compound casting

    Institute of Scientific and Technical Information of China (English)

    Konrad; J.; M.; PAPIS; Joerg; F.; LOEFFLER; Peter; J.; UGGOWITZER

    2009-01-01

    Compound casting’simplifies joining processes by directly casting a metallic melt onto a solid metal substrate. A continuously metallurgic transition is very important for industrial applications, such as joint structures of spaceframe constructions in transport industry. In this project, ‘compound casting’ of light metals is investigated, aiming at weight-saving. The substrate used is a wrought aluminium alloy of type AA5xxx, containing magnesium as main alloying element. The melts are aluminium alloys, containing various alloying elements (Cu, Si, Zn), and magnesium. By replacing the natural oxygen layer with a zinc layer, the inherent wetting difficulties were avoided, and compounds with flawless interfaces were successfully produced (no contraction defects, cracks or oxides). Electron microscopy and EDX investigations as well as optical micrographs of the interfacial areas revealed their continu- ously metallic constitution. Diffusion of alloying elements leads to heat-treatable microstructures in the vicinity of the joining interfaces in Al-Al couples. This permits significant variability of mechanical properties. Without significantly cutting down on wettability, the formation of low-melting intermetallic phases (Al3Mg2 and Al12Mg17 IMPs) at the interface of Al-Mg couples was avoided by applying a protective coating to the substrate.

  16. Light metal compound casting

    Institute of Scientific and Technical Information of China (English)

    Konrad J.M.PAPIS; Joerg F.LOEFFLER; Peter J.UGGOWITZER

    2009-01-01

    'Compound casting'simplifies joining processes by directly casting a metallic melt onto a solid metal substrate. A continuously metallurgic transition is very important for industrial applications, such as joint structures of spaceframe constructions in transport industry. In this project, 'compound casting' of light metals is investigated, aiming at weight-saving. The substrate used is a wrought aluminium alloy of type AA5xxx, containing magnesium as main alloying element. The melts are aluminium alloys, containing various alloying elements (Cu, Si, Zn), and magnesium. By replacing the natural oxygen layer with a zinc layer, the inherent wetting difficulties were avoided, and compounds with flawless interfaces were successfully produced (no contraction defects, cracks or oxides). Electron microscopy and EDX investigations as well as optical micrographs of the interfacial areas revealed their continu-ously metallic constitution. Diffusion of alloying elements leads to heat-treatable microstructures in the vicinity of the joining interfaces in Al-Al couples. This permits significant variability of mechanical properties. Without significantly cutting down on wettability, the formation of low-melting intermetallic phases (Al3Mg2 and AI12Mg17 IMPs) at the interface of Al-Mg couples was avoided by applying a protec-tive coating to the substrate.

  17. Offset Compound Gear Drive

    Science.gov (United States)

    Stevens, Mark A.; Handschuh, Robert F.; Lewicki, David G.

    2010-01-01

    The Offset Compound Gear Drive is an in-line, discrete, two-speed device utilizing a special offset compound gear that has both an internal tooth configuration on the input end and external tooth configuration on the output end, thus allowing it to mesh in series, simultaneously, with both a smaller external tooth input gear and a larger internal tooth output gear. This unique geometry and offset axis permits the compound gear to mesh with the smaller diameter input gear and the larger diameter output gear, both of which are on the same central, or primary, centerline. This configuration results in a compact in-line reduction gear set consisting of fewer gears and bearings than a conventional planetary gear train. Switching between the two output ratios is accomplished through a main control clutch and sprag. Power flow to the above is transmitted through concentric power paths. Low-speed operation is accomplished in two meshes. For the purpose of illustrating the low-speed output operation, the following example pitch diameters are given. A 5.0 pitch diameter (PD) input gear to 7.50 PD (internal tooth) intermediate gear (0.667 reduction mesh), and a 7.50 PD (external tooth) intermediate gear to a 10.00 PD output gear (0.750 reduction mesh). Note that it is not required that the intermediate gears on the offset axis be of the same diameter. For this example, the resultant low-speed ratio is 2:1 (output speed = 0.500; product of stage one 0.667 reduction and stage two 0.750 stage reduction). The design is not restricted to the example pitch diameters, or output ratio. From the output gear, power is transmitted through a hollow drive shaft, which, in turn, drives a sprag during which time the main clutch is disengaged.

  18. Oligosilanylated Antimony Compounds

    Science.gov (United States)

    2015-01-01

    By reactions of magnesium oligosilanides with SbCl3, a number of oligosilanylated antimony compounds were obtained. When oligosilanyl dianions were used, either the expected cyclic disilylated halostibine was obtained or alternatively the formation of a distibine was observed. Deliberate formation of the distibine from the disilylated halostibine was achieved by reductive coupling with C8K. Computational studies of Sb–Sb bond energies, barriers of pyramidal inversion at Sb, and the conformational behavior of distibines provided insight for the understanding of the spectroscopic properties. PMID:25937691

  19. Special Risks of Pharmacy Compounding

    Science.gov (United States)

    ... Consumer Updates RSS Feed The Special Risks of Pharmacy Compounding Get Consumer Updates by E-mail Consumer ... page: A Troubling Trend What You Can Do Pharmacy compounding is a practice in which a licensed ...

  20. High temperature superconducting compounds

    Science.gov (United States)

    Goldman, Allen M.

    1992-11-01

    The major accomplishment of this grant has been to develop techniques for the in situ preparation of high-Tc superconducting films involving the use of ozone-assisted molecular beam epitaxy. The techniques are generalizable to the growth of trilayer and multilayer structures. Films of both the DyBa2Cu3O(7-x) and YBa2Cu3O(7-x) compounds as well as the La(2-x)Sr(x)CuO4 compound have been grown on the usual substrates, SrTiO3, YSZ, MgO, and LaAlO3, as well as on Si substrates without any buffer layer. A bolometer has been fabricated on a thermally isolated SiN substrate coated with YSZ, an effort carried out in collaboration with Honeywell Inc. The deposition process facilitates the fabrication of very thin and transparent films creating new opportunities for the study of superconductor-insulator transitions and the investigation of photo-doping with carriers of high temperature superconductors. In addition to a thin film technology, a patterning technology has been developed. Trilayer structures have been developed for FET devices and tunneling junctions. Other work includes the measurement of the magnetic properties of bulk single crystal high temperature superconductors, and in collaboration with Argonne National Laboratory, measurement of electric transport properties of T1-based high-Tc films.

  1. Optimizing Synthetic Aperture Compound Imaging

    DEFF Research Database (Denmark)

    Hansen, Jens Munk; Jensen, Jørgen Arendt

    2012-01-01

    Spatial compound images are constructed from synthetic aperture data acquired using a linear phased-array transducer. Compound images of wires, tissue, and cysts are created using a method, which allows both transmit and receive compounding without any loss in temporal resolution. Similarly to co...

  2. Xenobiotic organic compounds in wastewater

    DEFF Research Database (Denmark)

    Eriksson, Eva; Baun, Anders; Henze, Mogens

    2002-01-01

    Information regarding the contents of xenobiotic organic compounds (XOCs) in wastewater is limited, but it has been shown that at least 900 different compounds / compound groups could potentially be present in grey wastewater. Analyses of Danish grey wastewater revealed the presence of several...

  3. Semiconducting III-V compounds

    CERN Document Server

    Hilsum, C; Henisch, Heinz R

    1961-01-01

    Semiconducting III-V Compounds deals with the properties of III-V compounds as a family of semiconducting crystals and relates these compounds to the monatomic semiconductors silicon and germanium. Emphasis is placed on physical processes that are peculiar to III-V compounds, particularly those that combine boron, aluminum, gallium, and indium with phosphorus, arsenic, and antimony (for example, indium antimonide, indium arsenide, gallium antimonide, and gallium arsenide).Comprised of eight chapters, this book begins with an assessment of the crystal structure and binding of III-V compounds, f

  4. Synthetic Aperture Compound Imaging

    DEFF Research Database (Denmark)

    Hansen, Jens Munk

    Medical ultrasound imaging is used for many purposes, e.g. for localizing and classifying cysts, lesions, and other processes. Almost any mass is first observed using B-mode imaging and later classified using e.g. color flow, strain, or attenuation imaging. It is therefore important that the B....... The method is investigated using simulations and through measurements using both phased array and convex array transducers. The images all show an improved contrast compared to images without compounding, and by construction, imaging using an improved frame rate is possible. Using a phased array transducer...... and the limiting factor is the amount of memory IO resources available. An equally high demand for memory throughput is found in the computer gaming industry, where a large part of the processing takes place on the graphics processing unit (GPU). Using the GPU, a framework for synthetic aperture imaging...

  5. Synthesis, Crystal Structure, Luminescent Properties and Thermogravimetric Analysis of a New Azido-bridged Zinc( Ⅱ ) Coordination Polymer%叠氮桥联锌配位聚合物的合成、晶体结构、荧光及热重性质研究

    Institute of Scientific and Technical Information of China (English)

    许明媛; 王海仙; 朱莉娜

    2011-01-01

    合成了一种新的配位聚合物{[Zn(azpy)2 (N3) (H2O)]·ClO4·0.5azpy}n(1),并对配合物进行了元素分析、红外及X-射线单晶衍射表征.在配合物1中,锌离子通过EO叠氮桥联和4,4’-azopyridine (azpy)桥联形成了梯子状的一维链状结构,此一维链通过O-H…N氢键和π-π作用进一步形成具有(4.82)(43.65.82)拓扑结构的三重穿插的超分子网络结构.研究了配合物的荧光及热重性质.%A new coordination polymer { [Zn (azpy)2 (N3) (H2O) ] · ClO4 · 0.5azpy }n (1) was synthesized and characterized by elemental analysis,IR,and single crystal X-ray diffraction,where azpy is 4,4'-azopyridine ligand.In complex 1,Zn( Ⅱ ) ions are bridged by end-on azido ligands and 4,4'-azopyridine (azpy) ligands into a one-dimensional ladder-like chain.Then,the O -H…N hydrogen bonds and π-π interactions further connect the 1-D chains to generate a 3-fold interpenetrating (3,5)-conected supramolecular networks with the topology of (4.82) (43.65.82).The luminescence spectra and thermogravimetric properties of 1 were also studied.

  6. Crystal structure of bis(azido-κNbis[2,5-bis(pyridin-2-yl-1,3,4-thiadiazole-κ2N2,N3]cobalt(II

    Directory of Open Access Journals (Sweden)

    Abdelhakim Laachir

    2015-05-01

    Full Text Available In the mononuclear title complex, [Co(N32(C12H8N4S2], the cobalt(II atom is located on an inversion centre and displays an axially weakly compressed octahedral coordination geometry. The equatorial positions are occupied by the N atoms of two 2,5-bis(pyridin-2-yl-1,3,4-thiadiazole ligands, whereas the axial positions are occupied by N atoms of the azide anions. The thiadiazole and pyridine rings linked to the metal are almost coplanar, with a maximum deviation from the mean plane of 0.0273 (16 Å. The cohesion of the crystal is ensured by weak C—H...N hydrogen bonds and by π–π interactions between pyridine rings [intercentroid distance = 3.6356 (11 Å], forming a layered arrangement parallel to (001. The structure of the title compound is isotypic with that of the analogous nickel(II complex [Laachir et al. (2013. Acta Cryst. E69, m351–m352].

  7. Tin compounds and insect fauna

    Energy Technology Data Exchange (ETDEWEB)

    Butovskiy, R.O.

    1985-03-01

    A review of the literature of tin compounds serving as pesticides has resulted in the identification of 11 widely used compounds, both organic and inorganic, with largely fungicidal activity. Organotin compounds seem to be limited in use to the control of insect pests, with the majority of the compounds consisting of Sn(IV) and falling into the following four categories: R/sub 4/Sn, R/sub 3/SNX, R/sub 2/SnX/sub 2/, and RSnX/sub 3/, where R = aliphatic or aromatic hydrocarbon radicals, and X = organic or inorganic substituent. The insecticidal activity of these compounds appears to rest on inhibition of ATPase and uncoupling of oxidative phosphorylation. As a result, these compounds act as larvicides, ovicides and imagocides. 77 references.

  8. Public chemical compound databases.

    Science.gov (United States)

    Williams, Anthony J

    2008-05-01

    The internet has rapidly become the first port of call for all information searches. The increasing array of chemistry-related resources that are now available provides chemists with a direct path to the information that was previously accessed via library services and was limited by commercial and costly resources. The diversity of the information that can be accessed online is expanding at a dramatic rate, and the support for publicly available resources offers significant opportunities in terms of the benefits to science and society. While the data online do not generally meet the quality standards of manually curated sources, there are efforts underway to gather scientists together and 'crowdsource' an improvement in the quality of the available data. This review discusses the types of public compound databases that are available online and provides a series of examples. Focus is also given to the benefits and disruptions associated with the increased availability of such data and the integration of technologies to data mine this information.

  9. Potential Risks of Pharmacy Compounding

    OpenAIRE

    Gudeman, Jennifer; Jozwiakowski, Michael; Chollet, John; Randell, Michael

    2013-01-01

    Pharmacy compounding involves the preparation of customized medications that are not commercially available for individual patients with specialized medical needs. Traditional pharmacy compounding is appropriate when done on a small scale by pharmacists who prepare the medication based on an individual prescription. However, the regulatory oversight of pharmacy compounding is significantly less rigorous than that required for Food and Drug Administration (FDA)-approved drugs; as such, compoun...

  10. Sesquiterpene compounds from Inula viscosa.

    Science.gov (United States)

    Fontana, Gianfranco; La Rocca, Salvatore; Passannanti, Salvatore; Paternostro, Maria Pia

    2007-07-20

    Two new compounds, 2,5-dihydroxyisocostic acid and 2,3-dihydroxycostic acid together with three known sesquiterpene compounds, Isocostic acid, Carabrone and Tomentosin, have been isolated from the acetone extract of Inula viscosa (L.) Aiton. The structures of all new compounds were determined by spectroscopic methods, in particular 1D and 2D (1)H- and (13)C-NMR. The (13)C-NMR spectra of Isocostic acid and of Tomentosin are reported here for the first time.

  11. Transition Metal Compounds Towards Holography

    Directory of Open Access Journals (Sweden)

    Volker Dieckmann

    2012-06-01

    Full Text Available We have successfully proposed the application of transition metal compounds in holographic recording media. Such compounds feature an ultra-fast light-induced linkage isomerization of the transition-metal–ligand bond with switching times in the sub-picosecond regime and lifetimes from microseconds up to hours at room temperature. This article highlights the photofunctionality of two of the most promising transition metal compounds and the photophysical mechanisms that are underlying the hologram recording. We present the latest progress with respect to the key measures of holographic media assembled from transition metal compounds, the molecular embedding in a dielectric matrix and their impressive potential for modern holographic applications.

  12. Natural compounds with herbicidal activity

    Directory of Open Access Journals (Sweden)

    Pasquale Montemurro

    2011-02-01

    Full Text Available Research about phytotoxic activity of natural compounds could lead both to find new herbicidal active ingredients and to plan environmental friendly weed control strategies. Particularly, living organisms could be a source of compounds that are impossible, for their complexity, to synthesize artificially. More over, they could have alternative sites of action respect to the known chemical herbicides and, due to their origin, they should be more environmental safe. Many living organism, such as bacteria, fungi, insects, lichens and plants, are able to produce bioactive compounds. They generally are secondary metabolites or simply waste molecules. In this paper we make a review about these compounds, highlighting potential and constraints.

  13. Saturn's Stratospheric Oxygen Compounds

    Science.gov (United States)

    Romani, Paul N.; Delgado Díaz, Héctor E.; Bjoraker, Gordon; Hesman, Brigette; Achterberg, Richard

    2016-10-01

    There are three known oxygenated species present in Saturn's upper atmosphere: H2O, CO and CO2. The ultimate source of the water must be external to Saturn as Saturn's cold tropopause effectively prevents any internal water from reaching the upper atmosphere. The carbon monoxide and dioxide source(s) could be internal, external, produced by the photochemical interaction of water with Saturn's stratospheric hydrocarbons or some combination of all of these. At this point it is not clear what the external source(s) are.Cassini's Composite InfraRed Spectrometer (CIRS) has detected emission lines of H2O and CO2 (Hesman et al., DPS 2015, 311.16 & Abbas et al. 2013, Ap. J. doi:10.1088/0004-637X/776/2/73) on Saturn. CIRS also retrieves the temperature of the stratosphere using CH4 lines at 7.7 microns. Using CIRS retrieved temperatures, the mole fraction of H2O at the 0.5-5 mbar level can be retrieved and the CO2 mole fraction at ~1-10 mbar. Coupled with ground based observations of CO (Cavalié et al., 2010, A&A, DOI: 10.1051/0004-6361/200912909) these observations provide a complete oxygen compound data set to test photochemical models.Preliminary results will be presented with an emphasis on upper limit analysis to determine the percentage of stratospheric CO and CO2 that can be produced photochemically from CIRS observational constraints on the H2O profile.

  14. Antimicrobial compounds in tears.

    Science.gov (United States)

    McDermott, Alison M

    2013-12-01

    The tear film coats the cornea and conjunctiva and serves several important functions. It provides lubrication, prevents drying of the ocular surface epithelia, helps provide a smooth surface for refracting light, supplies oxygen and is an important component of the innate defense system of the eye providing protection against a range of potential pathogens. This review describes both classic antimicrobial compounds found in tears such as lysozyme and some more recently identified such as members of the cationic antimicrobial peptide family and surfactant protein-D as well as potential new candidate molecules that may contribute to antimicrobial protection. As is readily evident from the literature review herein, tears, like all mucosal fluids, contain a plethora of molecules with known antimicrobial effects. That all of these are active in vivo is debatable as many are present in low concentrations, may be influenced by other tear components such as the ionic environment, and antimicrobial action may be only one of several activities ascribed to the molecule. However, there are many studies showing synergistic/additive interactions between several of the tear antimicrobials and it is highly likely that cooperativity between molecules is the primary way tears are able to afford significant antimicrobial protection to the ocular surface in vivo. In addition to effects on pathogen growth and survival some tear components prevent epithelial cell invasion and promote the epithelial expression of innate defense molecules. Given the protective role of tears a number of scenarios can be envisaged that may affect the amount and/or activity of tear antimicrobials and hence compromise tear immunity. Two such situations, dry eye disease and contact lens wear, are discussed here.

  15. Process for demethylating dimethylsulfonium compounds

    NARCIS (Netherlands)

    Hansen, Theo; van der Maarel, Marc

    1998-01-01

    PCT No. PCT/EP94/01640 Sec. 371 Date Nov. 14, 1995 Sec. 102(e) Date Nov. 14, 1995 PCT Filed May 16, 1994 PCT Pub. No. WO94/26918 PCT Pub. Date Nov. 24, 1994Process for preparing S-methylmercapto and mercapto compounds comprising the step of demethylating a dimethylsulfonium compound of formula I to

  16. Cytotoxic Compounds from Zanthoxylum Americanum

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Four pyranocoumarins: dipetaline, alloxanthoxyletin, xanthoxyletin, and xanthyletin, and two lignans: sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all six compounds inhibited the incorporation of tritiated thymidine into human leukemia (HL-60) cells and the inhibitory effect was dependent on the structures of the isolated compounds.

  17. Testing of Experimental Antileishmanial Compounds.

    Science.gov (United States)

    1994-10-19

    administrative and clerical assistance and Ms. Barbara L. Harris, Laboratory Technician II, for technical assistance with this study. Their efforts are appreciated...braziliensis) leishmaniasis . Although several new compounds have been identified with activity against L. (V.) braziliensis, none have shown adequate promise...to warrant initiation of clinical trials. However, among the most promising active compounds found against visceral leishmaniasis during these

  18. Electrochemical reactions of organosilicon compounds

    Science.gov (United States)

    Jouikov, Vyacheslav V.

    1997-06-01

    Data on the processes of electrochemical reduction and oxidation of organosilicon compounds of various classes as well as on the interaction of these compounds with electrically generated reagents are generalised and surveyed systematically. The electrochemical reactivity of organic derivatives of silicon is considered taking into account their structures and reaction conditions. The bibliography includes 245 references.

  19. II-VI semiconductor compounds

    CERN Document Server

    1993-01-01

    For condensed matter physicists and electronic engineers, this volume deals with aspects of II-VI semiconductor compounds. Areas covered include devices and applications of II-VI compounds; Co-based II-IV semi-magnetic semiconductors; and electronic structure of strained II-VI superlattices.

  20. Assimilation of Unusual Carbon Compounds

    Science.gov (United States)

    Middelhoven, Wouter J.

    Yeast taxa traditionally are distinguished by growth tests on several sugars and organic acids. During the last decades it became apparent that many yeast species assimilate a much greater variety of naturally occurring carbon compounds as sole source of carbon and energy. These abilities are indicative of a greater role of yeasts in the carbon cycle than previously assumed. Especially in acidic soils and other habitats, yeasts may play a role in the degradation of carbon compounds. Such compounds include purines like uric acid and adenine, aliphatic amines, diamines and hydroxyamines, phenolics and other benzene compounds and polysaccharides. Assimilation of purines and amines is a feature of many ascomycetes and basidiomycetes. However, benzene compounds are degraded by only a few ascomycetous yeasts (e.g. the Stephanoascus/ Blastobotrys clade and black yeastlike fungi) but by many basidiomycetes, e.g. Filobasidiales, Trichosporonales, red yeasts producing ballistoconidia and related species, but not by Tremellales. Assimilation of polysaccharides is wide-spread among basidiomycetes

  1. Bilayer Effects of Antimalarial Compounds.

    Directory of Open Access Journals (Sweden)

    Nicole B Ramsey

    Full Text Available Because of the perpetual development of resistance to current therapies for malaria, the Medicines for Malaria Venture developed the Malaria Box to facilitate the drug development process. We tested the 80 most potent compounds from the box for bilayer-mediated effects on membrane protein conformational changes (a measure of likely toxicity in a gramicidin-based stopped flow fluorescence assay. Among the Malaria Box compounds tested, four compounds altered membrane properties (p< 0.05; MMV007384 stood out as a potent bilayer-perturbing compound that is toxic in many cell-based assays, suggesting that testing for membrane perturbation could help identify toxic compounds. In any case, MMV007384 should be approached with caution, if at all.

  2. Complex chemistry with complex compounds

    Directory of Open Access Journals (Sweden)

    Eichler Robert

    2016-01-01

    Full Text Available In recent years gas-phase chemical studies assisted by physical pre-separation allowed for the investigation of fragile single molecular species by gas-phase chromatography. The latest success with the heaviest group 6 transactinide seaborgium is highlighted. The formation of a very volatile hexacarbonyl compound Sg(CO6 was observed similarly to its lighter homologues molybdenum and tungsten. The interactions of these gaseous carbonyl complex compounds with quartz surfaces were investigated by thermochromatography. Second-generation experiments are under way to investigate the intramolecular bond between the central metal atom of the complexes and the ligands addressing the influence of relativistic effects in the heaviest compounds. Our contribution comprises some aspects of the ongoing challenging experiments as well as an outlook towards other interesting compounds related to volatile complex compounds in the gas phase.

  3. Membrane rejection of nitrogen compounds

    Science.gov (United States)

    Lee, S.; Lueptow, R. M.

    2001-01-01

    Rejection characteristics of nitrogen compounds were examined for reverse osmosis, nanofiltration, and low-pressure reverse osmosis membranes. The rejection of nitrogen compounds is explained by integrating experimental results with calculations using the extended Nernst-Planck model coupled with a steric hindrance model. The molecular weight and chemical structure of nitrogen compounds appear to be less important in determining rejection than electrostatic properties. The rejection is greatest when the Donnan potential exceeds 0.05 V or when the ratio of the solute radius to the pore radius is greater than 0.8. The transport of solute in the pore is dominated by diffusion, although convective transport is significant for organic nitrogen compounds. Electromigration contributes negligibly to the overall solute transport in the membrane. Urea, a small organic compound, has lower rejection than ionic compounds such as ammonium, nitrate, and nitrite, indicating the critical role of electrostatic interaction in rejection. This suggests that better treatment efficiency for organic nitrogen compounds can be obtained after ammonification of urea.

  4. The demise of compound houses

    DEFF Research Database (Denmark)

    Andreasen, Jørgen; Eskemose Andersen, Jørgen

    2006-01-01

    and the neighbourhood unity is a challenge for urban planners. However they represent good value for money, cost little to build, suit traditional inheritence patterns, allow independent life at low cost and allow sharing of services with a finite and known group (albeit within a potential conflictive domain). Compound...... of compound housing and analyses the advantages and disadvantages of life within such housing in Kumasi. Issues of privacy, image and communal life are usually cited by occupants dissatiesfied with life in compound houses, and the difficulty of extending them without spoiling the open spaces...

  5. Polishing compound for plastic surfaces

    Science.gov (United States)

    Stowell, Michael S.

    1995-01-01

    A polishing compound for plastic surfaces. The compound contains by weight approximately 4 to 17 parts at least one petroleum distillate lubricant, 1 to 6 parts mineral spirits, 2.5 to 15 parts abrasive particles, and 2.5 to 10 parts water. The abrasive is tripoli or a similar material that contains fine particles silica. Preferably, most of the abrasive particles are less than approximately 10 microns, more preferably less than approximately 5 microns in size. The compound is used on PLEXIGLAS.TM., LEXAN.TM., LUCITE.TM., polyvinyl chloride (PVC) and similar plastic materials whenever a smooth, clear polished surface is desired.

  6. Fourth symposium on macrocyclic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, J. J.; Izatt, R. M.

    1980-01-01

    Both theoretical and experimental aspects of the properties and behavior of synthetic and naturally occurring macrocyclic compounds are covered in this symposium. This document contains abstracts of the papers. (DLC)

  7. Multi-angle compound imaging

    DEFF Research Database (Denmark)

    Jespersen, Søren Kragh; Wilhjelm, Jens Erik; Sillesen, Henrik

    1998-01-01

    to conventional B-mode imaging MACI offers better defined tissue boundaries and lower variance of the speckle pattern, resulting in an image with reduced random variations. Design and implementation of a compound imaging system is described, images of rubber tubes and porcine aorta are shown and effects......This paper reports on a scanning technique, denoted multi-angle compound imaging (MACI), using spatial compounding. The MACI method also contains elements of frequency compounding, as the transmit frequency is lowered for the highest beam angles in order to reduce grating lobes. Compared...... on visualization are discussed. The speckle reduction is analyzed numerically and the results are found to be in excellent agreement with existing theory. An investigation of detectability of low-contrast lesions shows significant improvements compared to conventional imaging. Finally, possibilities for improving...

  8. Optimization of compound gear pump

    Institute of Scientific and Technical Information of China (English)

    栾振辉

    2002-01-01

    This paper introduces the performances of compound gear pump. Based on the target of having the smallest mass per unit volume, the paper established a mathematical model of optimization, and obtained the results of optimization of the pump.

  9. Crystallographic properties of fertilizer compounds

    Energy Technology Data Exchange (ETDEWEB)

    Frazier, A.W.; Dillard, E.F.; Thrasher, R.D.; Waerstad, K.R.; Hunter, S.R.; Kohler, J.J.; Scheib, R.M.

    1991-02-01

    This bulletin is a compilation of crystallographic data collected at NFERC on 450 fertilizer-related compounds. In TVA's fertilizer R and D program, petrographic examination, XRD, and infrared spectroscopy are combined with conventional chemical analysis methods in identifying the individual compounds that occur in fertilizer materials. This handbook brings together the results of these characterization studies and supplemental crystallographic data from the literature. It is in one-compound-per-page, loose-leaf format, ordered alphabetically by IUPAC name. Indexes provided include IUPAC name, formula, group, alternate formula, synonyms, x-ray data, optical data. Tables are given for solids, compounds in commercial MAP and DAP, and matrix materials in phosphate rock.

  10. Cytotoxic Compounds from Brucea mollis

    OpenAIRE

    Tung, Mai Hung Thanh; Đuc, Ho Viet; Huong, Tran Thu; Nguyen Thanh DUONG; Do Thi PHUONG; Thao, Do Thi; Tai, Bui Huu; Kim, Young Ho; Bach, Tran The; Cuong, Nguyen Manh

    2012-01-01

    Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (...

  11. Miniature curved artificial compound eyes.

    Science.gov (United States)

    Floreano, Dario; Pericet-Camara, Ramon; Viollet, Stéphane; Ruffier, Franck; Brückner, Andreas; Leitel, Robert; Buss, Wolfgang; Menouni, Mohsine; Expert, Fabien; Juston, Raphaël; Dobrzynski, Michal Karol; L'Eplattenier, Geraud; Recktenwald, Fabian; Mallot, Hanspeter A; Franceschini, Nicolas

    2013-06-04

    In most animal species, vision is mediated by compound eyes, which offer lower resolution than vertebrate single-lens eyes, but significantly larger fields of view with negligible distortion and spherical aberration, as well as high temporal resolution in a tiny package. Compound eyes are ideally suited for fast panoramic motion perception. Engineering a miniature artificial compound eye is challenging because it requires accurate alignment of photoreceptive and optical components on a curved surface. Here, we describe a unique design method for biomimetic compound eyes featuring a panoramic, undistorted field of view in a very thin package. The design consists of three planar layers of separately produced arrays, namely, a microlens array, a neuromorphic photodetector array, and a flexible printed circuit board that are stacked, cut, and curved to produce a mechanically flexible imager. Following this method, we have prototyped and characterized an artificial compound eye bearing a hemispherical field of view with embedded and programmable low-power signal processing, high temporal resolution, and local adaptation to illumination. The prototyped artificial compound eye possesses several characteristics similar to the eye of the fruit fly Drosophila and other arthropod species. This design method opens up additional vistas for a broad range of applications in which wide field motion detection is at a premium, such as collision-free navigation of terrestrial and aerospace vehicles, and for the experimental testing of insect vision theories.

  12. Bioaccessibility testing of cobalt compounds.

    Science.gov (United States)

    Stopford, Woodhall; Turner, John; Cappellini, Danielle; Brock, Tom

    2003-08-01

    Testing of metal compounds for solubility in artificial fluids has been used for many years to assist determining human health risk from exposure to specific compounds of concern. In lieu of obtaining bioavailability data from samples of urine, blood, or other tissues, these studies measured solubility of compounds in various artificial fluids as a surrogate for bioavailability. In this context, the measurement of metal "bioaccessibility" can be used as an in vitro substitute for measuring metal bioavailability. Bioaccessibility can be defined as a value representing the availability of metal for absorption when dissolved in in vitro surrogates of body fluids or juices. The aim of this study was to measure and compare the bioaccessibility of selected cobalt compounds in artificial human tissue fluids and human serum. A second aim was to initiate studies to experimentally validate an in vitro methodology that would provide a conservative estimate of cobalt bioavailability in the assessment of dose from human exposure to various species of cobalt compounds. This study evaluated the bioaccessibility of cobalt(II) from 11 selected cobalt compounds and an alloy in 2 physical forms in 5 surrogate human tissue fluids and human serum. Four (4) separate extraction times were used up to 72 hours. The effect of variables such as pH, dissolution time, and mass-ion effect on cobalt bioaccessibility were assessed as well. We found that the species of cobalt compound as well as the physico-chemical properties of the surrogate fluids, especially pH, had a major impact on cobalt solubility. Cobalt salts such as cobalt(II) sulfate heptahydrate were highly soluble, whereas cobalt alloys used in medical implants and cobalt aluminate spinels used as pigments, showed minimal dissolution over the period of the assay.

  13. Associative asymmetry of compound words.

    Science.gov (United States)

    Caplan, Jeremy B; Boulton, Kathy L; Gagné, Christina L

    2014-07-01

    Early verbal-memory researchers assumed participants represent memory of a pair of unrelated items with 2 independent, separately modifiable, directional associations. However, memory for pairs of unrelated words (A-B) exhibits associative symmetry: a near-perfect correlation between accuracy on forward (A →?) and backward (?← B) cued recall. This was viewed as arguing against the independent-associations hypothesis and in favor of the hypothesis that associations are remembered as holistic units. Here we test the Holistic Representation hypothesis further by examining cued recall of compound words. If we suppose preexisting words are more unitized than novel associations, the Holistic Representation hypothesis predicts compound words (e.g., ROSE BUD) will have a higher forward-backward correlation than novel compounds (e.g., BRIEF TAX). We report the opposite finding: Compound words, as well as noncompound words, exhibited less associative symmetry than novel compounds. This challenges the Holistic Representation account of associative symmetry. Moreover, preexperimental associates (positional family size) influenced associative symmetry-but asymmetrically: Increasing family size of the last constituent increasing decoupled forward and backward recall, but family size of the 1st constituent had no such effect. In short, highly practiced, meaningful associations exhibit associative asymmetry, suggesting associative symmetry is not diagnostic of holistic representations but, rather, is a characteristic of ad hoc associations. With additional learning, symmetric associations may be replaced by directional, independently modifiable associations as verbal associations become embedded within a rich knowledge structure.

  14. Cytotoxic Compounds from Brucea mollis

    Directory of Open Access Journals (Sweden)

    Mai Hung Thanh TUNG

    2016-09-01

    Full Text Available Ten compounds, including soulameanone (1, isobruceine B (2, 9-methoxy-canthin-6-one (3, bruceolline F (4, niloticine (5, octatriacontan-1-ol (6, bombiprenone (7, α-tocopherol (8, inosine (9, and apigenin 7-O-β-D-glucopyranoside (10, were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one- and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth, LU-1 (human lung adenocarcinoma, LNCaP (human prostate adeno-carcinoma, and HL-60 (human promyelocytic leukemia cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1–4 μg/mL. Compounds 9-methoxycanthin-6-one (3 and niloticine (5 have been discovered for the first time from the Brucea genus.

  15. Compounds in food packaging materials

    DEFF Research Database (Denmark)

    Rosenmai, Anna Kjerstine

    Food contact materials (FCMs) are sources of food contamination and human chemical exposure. Some chemicals in these materials are known to cause adverse effects, but many are poorly characterized for their potential toxicological hazards making risk assessment a challenge. The aim of the project....... It is recommended to test more FCMs of paper and board with the strategy to obtain information on other potentially problematic compounds present in these materials. The presented data overall suggest that some compounds present in FCMs or suspected of being used can exert endocrine activities in vitro, though...... the implications of these findings with respect to effects in humans and exposure to humans remain largely unknown. Nevertheless, it is of concern that so many of the materials and compounds led to effects and calls for further studies to be conducted. The data obtained in this PhD can be used as a prioritization...

  16. [Triterpene compounds from Cirsium setosum].

    Science.gov (United States)

    Li, Lingling; Sun, Zheng; Shang, Xiaoya; Li, Jinjie; Wang, Rong; Zhu, Jie

    2012-04-01

    To investigate chemical constituents contained in cytotoxic petroleum ether extractive fractions from ethanol extracts of Cirsium setosum. The constituents were separated and purified by a combination of various chromatographic methods including silica gel, Sephadex LH-20, and preparative HPLC. Structures of the isolates were elucidated by spectroscopic methods including 1D, 2D NMR and MS methods. The compound structures were also determined by reference to literature. Twelve compounds were separated from the petroleum ether fraction of ethanolic extract and elucidated as lupenyl acetate (1), lupeol (2), lupenone (3), beta-amyrin (4), psi-taraxasterol (5), psi-taraxasteryl acetate (6), taraxasteryl acetate (7), marsformoxide B (8), alpha-amyrenone (9), beta-amyrenone (10), taraxasterone (11) and psi-taraxasterone (12). Of them, compounds 3, 5, 7-12 were separated from this genus for the first time.

  17. Electronic Configuration of Yb Compounds

    Energy Technology Data Exchange (ETDEWEB)

    Temmerman, W.M.; Szotek, Z. [Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, Cheshire (United Kingdom); Svane, A. [Institute of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C (Denmark); Strange, P. [Physics Department, Keele University, Keele, Staffordshire, ST5 5BG (United Kingdom); Winter, H. [INFP, Forschungszentrum Karlsruhe GmbH, Postfach 3640, D-76021 Karlsruhe (Germany); Delin, A.; Johansson, B.; Eriksson, O.; Fast, L. [Condensed Matter Theory Group, Department of Physics, University of Uppsala, Box 530, 75121 Uppsala (Sweden); Wills, J.M. [Center of Materials Science and Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87544 (United States)

    1999-11-01

    The total energy differences between divalent and trivalent configurations of Yb ions in a number of Yb compounds are studied. Two different band theoretical methods, which differ in the treatment of the localized f electrons, are used. The results show that in all Yb compounds the valence energy differences are equal to the energy needed to localize an f electron. These valence energy differences correlate with the number of f electrons hybridizing with the conduction bands in the trivalent configuration. For divalent YbS, the pressure induced f -electron delocalization implies an intermediate valency, as also indicated by experiment. {copyright} {ital 1999} {ital The American Physical Society }

  18. The structures of binary compounds

    CERN Document Server

    Hafner, J; Jensen, WB; Majewski, JA; Mathis, K; Villars, P; Vogl, P; de Boer, FR

    1990-01-01

    - Up-to-date compilation of the experimental data on the structures of binary compounds by Villars and colleagues. - Coloured structure maps which order the compounds into their respective structural domains and present for the first time the local co-ordination polyhedra for the 150 most frequently occurring structure types, pedagogically very helpful and useful in the search for new materials with a required crystal structure. - Crystal co-ordination formulas: a flexible notation for the interpretation of solid-state structures by chemist Bill Jensen. - Recent important advances in unders

  19. Moessbauer spectroscopy in neptunium compounds

    Energy Technology Data Exchange (ETDEWEB)

    Nakamoto, Tadahiro; Nakada, Masami; Masaki, Nobuyuki; Saeki, Masakatsu [Japan Atomic Energy Research Inst., Tokyo (Japan)

    1997-03-01

    Moessbauer effects are observable in seven elements of actinides from {sup 232}Th to {sup 247}Cm and Moesbauer spectra have been investigated mainly with {sup 237}Np and {sup 238}U for the reasons of availability and cost of materials. This report describes the fundamental characteristics of Moessbauer spectra of {sup 237}Np and the correlation between the isomer shift and the coordination number of Np(V) compounds. The isomer shifts of Np(V) compounds had a tendency to increase as an increase of coordination number and the isomer shifts of Np(V) compounds showed broad distribution as well as those of Np(VI) but {delta} values of the compounds with the same coordination number were distributed in a narrow range. The {delta} values of Np(VI) complexes with O{sub x} donor set suggest that the Np atom in its hydroxide (NpO{sub 2}(OH){center_dot}4H{sub 2}O)might have pentagonal bipyramidal structure and at least, pentagonal and hexagonal bipyramidal structures might coexist in its acetate and benzoate. Really, such coexistence has been demonstrated in its nitrate, (NpO{sub 2}){sub 2}(NO{sub 3}){sub 2}{center_dot}5H{sub 2}O. (M.N.)

  20. Assimilation of Unusual Carbon Compounds

    NARCIS (Netherlands)

    Middelhoven, W.J.

    2009-01-01

    Yeast taxa traditionally are distinguished by growth tests on several sugars and organic acids. During the last decades it became apparent that many yeast species assimilate a much greater variety of naturally occurring carbon compounds as sole source of carbon and energy. These abilities are indica

  1. Organophosphorus Compounds in Organic Electronics.

    Science.gov (United States)

    Shameem, Muhammad Anwar; Orthaber, Andreas

    2016-07-25

    This Minireview describes recent advances of organophosphorus compounds as opto-electronic materials in the field of organic electronics. The progress of (hetero-) phospholes, unsaturated phosphanes, and trivalent and pentavalent phosphanes since 2010 is covered. The described applications of organophosphorus materials range from single molecule sensors, field effect transistors, organic light emitting diodes, to polymeric materials for organic photovoltaic applications.

  2. Bacterial degradation of fluorinated compounds

    NARCIS (Netherlands)

    Ferreira, Maria Isabel Martins

    2007-01-01

    Fluorine was produced for the first time by Henri Moissan in 1886, for which he received the Nobel Prize in chemistry in 1906. The unique properties of fluorine have led to the development of fluorine chemistry and numerous synthetic fluorinated compounds have been prepared and tested for different

  3. Students' Categorizations of Organic Compounds

    Science.gov (United States)

    Domin, Daniel S.; Al-Masum, Mohammad; Mensah, John

    2008-01-01

    Categorization is a fundamental psychological ability necessary for problem solving and many other higher-level cognitive tasks. In organic chemistry, students must establish groupings of different chemical compounds in order not only to solve problems, but also to understand course content. Classic models of categorization emphasize similarity as…

  4. Compounding errors in 2 dogs receiving anticonvulsants.

    Science.gov (United States)

    McConkey, Sandra E; Walker, Susan; Adams, Cathy

    2012-04-01

    Two cases that involve drug compounding errors are described. One dog exhibited increased seizure activity due to a compounded, flavored phenobarbital solution that deteriorated before the expiration date provided by the compounder. The other dog developed clinical signs of hyperkalemia and bromine toxicity following a 5-fold compounding error in the concentration of potassium bromide (KBr).

  5. Microstructural degradation in compound tubes

    Energy Technology Data Exchange (ETDEWEB)

    Salonen, J.; Auerkari, P. [VTT Manufacturing Technology, Espoo (Finland)

    1996-12-31

    In order to quantify microstructural degradation at high temperatures, samples of SA 210 / AISI 304 L compound tube material were annealed in the temperature range 540-720 deg C for 1 to 1 000 hours. The hardness of the annealed material was measured and the micro structure of the samples was investigated with optical and scanning electron microscopy. Microstructural degradation was characterised by the carbide structure in the ferritic-pearlitic base material and by the depth of decarburised and carburised zones of the compound tube interface. The observed changes were quantified in terms of their time and temperature dependence and diffusion coefficients of the process. The results can be used in estimating the extent of thermal exposure of high-temperature components after long-term service or after incidences of overheating. (orig.) (4 refs.)

  6. Alkylation of organic aromatic compounds

    Science.gov (United States)

    Smith, L.A. Jr.

    1989-07-18

    Aromatic compounds are alkylated in a catalytic distillation, wherein the catalyst structure also serves as a distillation component by contacting the aromatic compound with a C[sub 2] to C[sub 10] olefin in the catalyst bed under 0.25 to 50 atmospheres of pressure and at temperatures in the range of 80 C to 500 C, using as the catalyst a mole sieve characterized as acidic or an acidic cation exchange resin. For example, ethyl benzene is produced by feeding ethylene below the catalyst bed while benzene is conveniently added through the reflux in molar excess to that required to react with ethylene, thereby reacting substantially all of the ethylene and recovering benzene as the principal overhead and ethyl benzene in the bottoms. 1 fig.

  7. Bacterial Degradation of Aromatic Compounds

    Directory of Open Access Journals (Sweden)

    Qing X. Li

    2009-01-01

    Full Text Available Aromatic compounds are among the most prevalent and persistent pollutants in the environment. Petroleum-contaminated soil and sediment commonly contain a mixture of polycyclic aromatic hydrocarbons (PAHs and heterocyclic aromatics. Aromatics derived from industrial activities often have functional groups such as alkyls, halogens and nitro groups. Biodegradation is a major mechanism of removal of organic pollutants from a contaminated site. This review focuses on bacterial degradation pathways of selected aromatic compounds. Catabolic pathways of naphthalene, fluorene, phenanthrene, fluoranthene, pyrene, and benzo[a]pyrene are described in detail. Bacterial catabolism of the heterocycles dibenzofuran, carbazole, dibenzothiophene, and dibenzodioxin is discussed. Bacterial catabolism of alkylated PAHs is summarized, followed by a brief discussion of proteomics and metabolomics as powerful tools for elucidation of biodegradation mechanisms.

  8. Polymer-solvent molecular compounds

    CERN Document Server

    Guenet, Jean-Michel

    2010-01-01

    Crystallisable polymers represent a large share of the polymers used for manufacturing a wide variety of objects, and consequently have received continuous attention from scientists these past 60 years. Molecular compounds from crystallisable polymers, particularly from synthetic polymers, are receiving growing interest due to their potential application in the making of new materials such as multiporous membranes capable of capturing large particles as well as small pollutant molecules. The present book gives a detailed description of these promising systems. The first chapter

  9. Compound facial expressions of emotion.

    Science.gov (United States)

    Du, Shichuan; Tao, Yong; Martinez, Aleix M

    2014-04-15

    Understanding the different categories of facial expressions of emotion regularly used by us is essential to gain insights into human cognition and affect as well as for the design of computational models and perceptual interfaces. Past research on facial expressions of emotion has focused on the study of six basic categories--happiness, surprise, anger, sadness, fear, and disgust. However, many more facial expressions of emotion exist and are used regularly by humans. This paper describes an important group of expressions, which we call compound emotion categories. Compound emotions are those that can be constructed by combining basic component categories to create new ones. For instance, happily surprised and angrily surprised are two distinct compound emotion categories. The present work defines 21 distinct emotion categories. Sample images of their facial expressions were collected from 230 human subjects. A Facial Action Coding System analysis shows the production of these 21 categories is different but consistent with the subordinate categories they represent (e.g., a happily surprised expression combines muscle movements observed in happiness and surprised). We show that these differences are sufficient to distinguish between the 21 defined categories. We then use a computational model of face perception to demonstrate that most of these categories are also visually discriminable from one another.

  10. Studying the Propensity of Compounds to Supersaturate

    DEFF Research Database (Denmark)

    Palmelund, Henrik; Madsen, Cecilie Maria; Plum, Jakob;

    2016-01-01

    Supersaturating drug delivery systems can enhance the oral bioavailability of poorly soluble drug compounds. Supersaturation of such compounds has been studied in many different ways; however, a more standardized method is required. The rationale of choosing suitable concentrations of supersatura......Supersaturating drug delivery systems can enhance the oral bioavailability of poorly soluble drug compounds. Supersaturation of such compounds has been studied in many different ways; however, a more standardized method is required. The rationale of choosing suitable concentrations...... of supersaturation to study has previously been very inconsistent. This makes comparisons between studies and compounds difficult, as the propensity of compounds to supersaturate varies greatly. This study presents a standardized method to study the supersaturation of drug compounds. The method allows, both......, for a ranking of compounds according to their supersaturation propensity and the effectiveness of precipitation inhibitors. The time-concentration profile of supersaturation and precipitation was studied in situ for 4 different concentrations for 6 model compounds (albendazole, aprepitant, danazol, felodipine...

  11. Volatile flavor compounds in yogurt: a review.

    Science.gov (United States)

    Cheng, Hefa

    2010-11-01

    Considerable knowledge has been accumulated on the volatile compounds contributing to the aroma and flavor of yogurt. This review outlines the production of the major flavor compounds in yogurt fermentation and the analysis techniques, both instrumental and sensory, for quantifying the volatile compounds in yogurt. The volatile compounds that have been identified in plain yogurt are summarized, with the few key aroma compounds described in detail. Most flavor compounds in yogurt are produced from lipolysis of milkfat and microbiological transformations of lactose and citrate. More than 100 volatiles, including carbonyl compounds, alcohols, acids, esters, hydrocarbons, aromatic compounds, sulfur-containing compounds, and heterocyclic compounds, are found in yogurt at low to trace concentrations. Besides lactic acid, acetaldehyde, diacetyl, acetoin, acetone, and 2-butanone contribute most to the typical aroma and flavor of yogurt. Extended storage of yogurt causes off-flavor development, which is mainly attributed to the production of undesired aldehydes and fatty acids during lipid oxidation. Further work on studying the volatile flavor compounds-matrix interactions, flavor release mechanisms, and the synergistic effect of flavor compounds, and on correlating the sensory properties of yogurt with the compositions of volatile flavor compounds are needed to fully elucidate yogurt aroma and flavor.

  12. Nitrogen Compounds in Radiation Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Sims, H.E. [NNL Sellafield (United Kingdom); Dey, G.R. [Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Vaudey, C.E.; Peaucelle, C. [Institut de Physique Nucleaire de Lyon - IPNL, 69 - Lyon (France); Boucher, J.L. [Lab. de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS 45 rue des Saints Peres, 75270 Paris cedex 06, Univ Paris 5, 75 (France); Toulhoat, N. [Institut de Physique Nucleaire de Lyon (France); Commissariat a l' Energie Atomique CEA/DEN, Centre de Saclay (France); Bererd, N. [Institut de Physique Nucleaire de Lyon (France); IUT Departement Chimie, Universite Claude Bernard Lyon 1 (France); Koppenol, W.H. [Department of Chemistry and Applied Biosciences, ETH Zurich (Switzerland); Janata, E. [Helmholtz-Zentrum fuer Materialien und Energie, Solar Energy Research, Berlin (Germany); Dauvois, V.; Durand, D.; Legand, S.; Roujou, J.L.; Doizi, D.; Dannoux, A.; Lamouroux, C. [Laboratoire de Speciation des Radionucleides et des Molecules, DEN/DPC/Service d' Etude du Comportement des Radionucleides, CEA Saclay, 91 - Gif sur yvette (France)

    2009-07-01

    Water radiolysis in presence of N{sub 2} is probably the topic the most controversy in the field of water radiolysis. It still exists a strong discrepancy between the different reports of ammonia formation by water radiolysis in presence of N{sub 2} and moreover in absence of oxygen there is no agreement on the formation or not of nitrogen oxide like NO{sub 2}- and NO{sub 3}-. These discrepancies come from multiple sources: - the complexity of the reaction mechanisms where nitrogen is involved - the experimental difficulties - and, the irradiation conditions. The aim of the workshop is to capitalize the knowledge needed to go further in simulations and understanding the problems caused (or not) by the presence of nitrogen / water in the environment of radioactive materials. Implications are evident in terms of corrosion, understanding of biological systems and atmospheric chemistry under radiation. Topics covered include experimental and theoretical approaches, application and fundamental researches: - Nitrate and Ammonia in radiation chemistry in nuclear cycle; - NOx in biological systems and atmospheric chemistry; - Formation of Nitrogen compounds in Nuclear installations; - Nitrogen in future power plant projects (Gen4, ITER...) and large particle accelerators. This document gathers the transparencies available for 7 of the presentations given at this workshop. These are: - H.E SIMS: 'Radiation Chemistry of Nitrogen Compounds in Nuclear Power Plant'; - G.R. DEY: 'Nitrogen Compounds Formation in the Radiolysis of Aqueous Solutions'; - C.E. VAUDEY et al.: 'Radiolytic corrosion of nuclear graphite studied with the dedicated gas irradiation cell of IPNL'; - J.L. BOUCHER: 'Roles and biosynthesis of NO in eukaryotes and prokaryotes'; - W.H. KOPPENOL: 'Chemistry of NOx'; - E. JANATA: 'Yield of OH in N{sub 2}O saturated aqueous solution'; - V. DAUVOIS: 'Analytical strategy for the study of radiolysis gases'

  13. Unpacking Noun-Noun Compounds

    DEFF Research Database (Denmark)

    Smith, Viktor; Barratt, Daniel; Zlatev, Jordan

    2014-01-01

    market and using Danish NNCs. Specifically, we addressed a highly productive type of compound food names where the modifier denotes a geographical entity and the head denotes a type of food, e.g. Hawaii pizza. Our findings contribute new evidence to central issues of (cognitive) linguistic theory...... concerning the relations between semantics and pragmatics, as well as system and usage, and psycholinguistic issues concerning the processing of NNCs. New insights and methodological tools are also provided for supporting future best practices in the field of food naming and labelling...

  14. First flush of dissolved compounds

    DEFF Research Database (Denmark)

    Krebs, P.; Holzer, P.; Huisman, J.L.

    1999-01-01

    . It is known that since the wave celerity is higher than the flow velocity of the water, the increase of flow rate induced through rain runoff is recognised earlier at a certain downstream section of the combined sewer than the concentration increase of typical rain-water compounds originating from surface...... on the receiving water, when a combined sewer overflow occurs, and also on the wastewater treatment plant when the sewer network is flat and catchment area is big. (C) 1999 Published by Elsevier Science Ltd on behalf of the IAWQ. All rights reserved....

  15. Bacterial degradation of detergent compounds.

    Science.gov (United States)

    Goodnow, R A; Harrison, A P

    1972-10-01

    A survey for surfactant degradation among aerobic bacteria has been undertaken. Tests have been made in peptone medium where such a degradation, if it occurs, will be gratuitous. Tallow-alkyl-sulfate, alkyl-ethoxylate-sulfate, and linear-alkyl-benzene-sulfonate were used. Forty-five strains of 34 species in 19 genera degrade one or more of these detergent compounds. With some species, the surfactant inhibits degradation without inhibiting growth, whereas with one species slight degradation took place even at a toxic concentration of surfactant.

  16. Aroma compounds in fresh cut pomegranate arils.

    Science.gov (United States)

    Little published information exists regarding flavor and aroma compounds in pomegranate (Punica granatum). Although arils have fruity and sweet characteristics, we found no publications describing actual compounds responsible for their typical flavor. Since most commercial usage of pomegranates in...

  17. Therapeutic Phytogenic Compounds for Obesity and Diabetes

    Directory of Open Access Journals (Sweden)

    Hee Soong Jung

    2014-11-01

    Full Text Available Natural compounds have been used to develop drugs for many decades. Vast diversities and minimum side effects make natural compounds a good source for drug development. However, the composition and concentrations of natural compounds can vary. Despite this inconsistency, half of the Food and Drug Administration (FDA-approved pharmaceuticals are natural compounds or their derivatives. Therefore, it is essential to continuously investigate natural compounds as sources of new pharmaceuticals. This review provides comprehensive information and analysis on natural compounds from plants (phytogenic compounds that may serve as anti-obesity and/or anti-diabetes therapeutics. Our growing understanding and further exploration of the mechanisms of action of the phytogenic compounds may afford opportunities for development of therapeutic interventions in metabolic diseases.

  18. Formation of Reissert compound of bisbenzimidazole

    OpenAIRE

    1990-01-01

    A Reissert compound of bisbenzimidazole can be formed by first reacting benzimidazole with an aliphatic diacid chloride to form bisbenzimidazole and then reacting the bisbenzimidazole with an aliphatic acid chloride and cyanide to form the Reissert compound thereof.

  19. Lipid encapsulated phenolic compounds by fluidization

    Science.gov (United States)

    Phenolic compounds exhibit antioxidant and antimicrobial activities with applications as functional food and feed additives. Ferulic acid, a phenolic compound present in grain crops and lignocellulose biomass, was encapsulated with saturated triglycerides using a laboratory fluidizer. Stability of t...

  20. Preparation, morphologies and thermal behavior of high nitrogen compound 2-amino-4,6-diazido-s-triazine and its derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Qi-Long, E-mail: terry.well@163.com [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice (Czech Republic); Musil, Tomáš [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice (Czech Republic); Zeman, Svatopluk, E-mail: svatopluk.zeman@upce.cz [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice (Czech Republic); Matyáš, Robert [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice (Czech Republic); Shi, Xiao-Bing [Xi‘an Modern Chemistry Research Institute, 710065 Xi’an (China); Vlček, Milan [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 12006 Prague (Czech Republic); Pelikán, Vojtěch [Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice (Czech Republic)

    2015-03-20

    Graphical abstract: High nitrogen compound 2-amino-4,6-diazido-s-triazine (DAAT) can be substituted by different function groups, forming many other new energetic materials. Such materials that have very close molecular structure may be very different in terms of crystal structure, thermal behavior, as well as performances (e.g., TAAT vs. TAHT). Generally, the increase of the molecular weight results in better thermal stability. - Highlights: • The crystal morphologies of azido-triazine derivatives are examined using SEM. • The thermal stability and decomposition processes are compared by TGA and DSC. • The effect of function group on the thermal behavior of title compounds is clarified. - Abstract: The crystal morphologies, thermal behavior, sensitivity and performance of 2-amino-4,6,-diazido-s-triazine and its derivatives have been investigated using SEM, DSC, TG techniques and related theories. It has been shown that the DANT crystal is in 1–5 μm thickness layered regular hexagon structure with severe agglomeration. DAAT crystal is very hydrophobic and can be dispersed in water, which has layered rectangle structure with thickness less than 0.5 μm. The TAHT materials exist in a form of amorphous irregular particles with diameters of more than 200 μm while its analogue TAAT can be crystallized in needle shape with a length of 30 μm. TNADAzT crystal has a shape of regular polyhedron with average size of about 120 μm. The thermal analysis indicates that there is only one complex step for decomposition of DAAT, while at least three steps are included for the other materials. DAAT started to decompose at around 148.4 °C with a peak temperature of 197.0 °C, while TAHT started to decompose at 167.2 °C with shoulder-peak of 193.4–206.7 °C at the heating rate of 2.0 °C min{sup −1}. DANT decomposes with a heat release of 2420–2721 J g{sup −1}, which is much higher than that of DAAT indicating that the heat and its release rate are greatly

  1. Bioavailability of dietary phenolic compounds: Review

    OpenAIRE

    Erick Gutiérrez-Grijalva Paul Gutiérrez-Grijalva; Dulce Libna Ambriz-Pérez; Nayely Leyva-López; Ramón Ignacio Castillo-López; José Basilio Heredia

    2015-01-01

    Phenolic compounds are ubiquitous in plant-based foods. High dietary intake of fruits, vegetables and cereals is related to a decreased rate in chronic diseases. Phenolic compounds are thought to be responsible, at least in part, for those health effects. Nonetheless, phenolic compounds bioaccessibility and biotransformation is often not considered in these studies; thus, a precise mechanism of action of phenolic compounds is not known. In this review we aim to present a comprehensive knowled...

  2. Two new acetylenic compounds from Asparagus officinalis.

    Science.gov (United States)

    Li, Xue-Mei; Cai, Jin-Long; Wang, Wen-Xiang; Ai, Hong-Lian; Mao, Zi-Chao

    2016-01-01

    Two new acetylenic compounds, asparoffins A (1) and B (2), together with two known compounds, nyasol (3) and 3″-methoxynyasol (4), were isolated from stems of Asparagus officinalis. The structures of two new compounds were elucidated on the basis of detailed spectroscopic analyses (UV, IR, MS, 1D, and 2D NMR). All compounds were evaluated for their cytotoxicities against three human cancer cell lines.

  3. Prebiotic Evolution of Nitrogen Compounds

    Science.gov (United States)

    Arrhenius, G.

    1999-01-01

    Support from this four year grant has funded our research on two general problems. One involves attempts to model the abiotic formation of simple source compounds for functional biomolecules, their concentration from dilute state in the hydrosphere and, in several cases, surface induced reactions to form precursor monomers for bioactive end products (refs. 1-5). Because of the pervasiveness and antiquity of phosphate based biochemistry and the catalytic activity of RNA we have exploring the hypothesis of an RNA World as an early stage in the emergence of life. This concept is now rather generally considered, but has been questioned due to the earlier lack of an experimentally demonstrated successful scheme for the spontaneous formation of ribose phosphate, the key backbone molecule in RNA. That impediment has now been removed. This has been achieved by demonstrating probable sources of activated (condensed) highly soluble and strongly sorbed phosphates in nature (Refs. 1,2) and effective condensation of aldehyde phosphates to form ribose phosphate in high yield (ref.6), thereby placing the RNA World concept on a somewhat safer experimental footing. Like all work in this field these experiments are oversimplifications that largely ignore competing side reactions with other compounds expected to be present. None the less our choice of experimental conditions aim at selective processes that eliminate interfering reactions. We have also sought to narrow the credibility gap by simulating geophysically and geochemically plausible conditions surrounding the putative prebiotic reactions.

  4. Corrosion Preventive Compounds Lifetime Testing

    Science.gov (United States)

    Hale, Stephanie M.; Kammerer, Catherine C.; Copp, Tracy L.

    2007-01-01

    Lifetime Testing of Corrosion Preventive Compounds (CPCs) was performed to quantify performance in the various environments to which the Space Shuttle Orbiter is exposed during a flight cycle. Three CPCs are approved for use on the Orbiter: RD Calcium Grease, Dinitrol AV-30, and Braycote 601 EF. These CPCs have been rigorously tested to prove that they mitigate corrosion in typical environments, but little information is available on how they perform in the unique combination of the coastal environment at the launch pad, the vacuum of low-earth orbit, and the extreme heat of reentry. Currently, there is no lifetime or reapplication schedule established for these compounds that is based on this combination of environmental conditions. Aluminum 2024 coupons were coated with the three CPCs and exposed to conditions that simulate the environments to which the Orbiter is exposed. Uncoated Aluminum 2024 coupons were exposed to the environmental conditions as a control. Visual inspection and Electro- Impedance Spectroscopy (EIS) were performed on the samples in order to determine the effectiveness of the CPCs. The samples were processed through five mission life cycles or until the visual inspection revealed the initiation of corrosion and EIS indicated severe degradation of the coating.

  5. Superconductivity in graphite intercalation compounds

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Robert P. [Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE (United Kingdom); Weller, Thomas E.; Howard, Christopher A. [Department of Physics & Astronomy, University College of London, Gower Street, London WCIE 6BT (United Kingdom); Dean, Mark P.M. [Department of Condensed Matter Physics and Materials Science, Brookhaven National Laboratory, Upton, NY 11973 (United States); Rahnejat, Kaveh C. [Department of Physics & Astronomy, University College of London, Gower Street, London WCIE 6BT (United Kingdom); Saxena, Siddharth S. [Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE (United Kingdom); Ellerby, Mark, E-mail: mark.ellerby@ucl.ac.uk [Department of Physics & Astronomy, University College of London, Gower Street, London WCIE 6BT (United Kingdom)

    2015-07-15

    Highlights: • Historical background of graphite intercalates. • Superconductivity in graphite intercalates and its place in the field of superconductivity. • Recent developments. • Relevant modeling of superconductivity in graphite intercalates. • Interpretations that pertain and questions that remain. - Abstract: The field of superconductivity in the class of materials known as graphite intercalation compounds has a history dating back to the 1960s (Dresselhaus and Dresselhaus, 1981; Enoki et al., 2003). This paper recontextualizes the field in light of the discovery of superconductivity in CaC{sub 6} and YbC{sub 6} in 2005. In what follows, we outline the crystal structure and electronic structure of these and related compounds. We go on to experiments addressing the superconducting energy gap, lattice dynamics, pressure dependence, and how these relate to theoretical studies. The bulk of the evidence strongly supports a BCS superconducting state. However, important questions remain regarding which electronic states and phonon modes are most important for superconductivity, and whether current theoretical techniques can fully describe the dependence of the superconducting transition temperature on pressure and chemical composition.

  6. Semiconducting compounds and devices incorporating same

    Energy Technology Data Exchange (ETDEWEB)

    Marks, Tobin J; Facchetti, Antonio; Boudreault, Pierre-Luc; Miyauchi, Hiroyuki

    2014-06-17

    Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability. Organic transistor and photovoltaic devices incorporating the present compounds as the active layer exhibit good device performance.

  7. Semiconducting compounds and devices incorporating same

    Energy Technology Data Exchange (ETDEWEB)

    Marks, Tobin J.; Facchetti, Antonio; Boudreault, Pierre-Luc; Miyauchi, Hiroyuki

    2016-01-19

    Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability. Organic transistor and photovoltaic devices incorporating the present compounds as the active layer exhibit good device performance.

  8. Low-molecular compounds of erythrocytes

    Directory of Open Access Journals (Sweden)

    O. O. Sorochan

    2006-01-01

    Full Text Available Glucose and free amino acids levels in rats’ blood plasma and erythrocytes hemolysate under carcinoma Geuren Т8 development as well as after introduction of Rhenium (III and сys-Platinum compounds were studied. The complex Rhenium (III compounds with organic ligands act as antioxidant and normalize the concentration of low-molecular compounds in erythrocytes under the carcinogenesis.

  9. Highly sweet compounds of plant origin.

    Science.gov (United States)

    Kim, Nam-Cheol; Kinghorn, A Douglas

    2002-12-01

    The demand for new alternative "low calorie" sweeteners for dietetic and diabetic purposes has increased worldwide. Although the currently developed and commercially used highly sweet sucrose substitutes are mostly synthetic compounds, the search for such compounds from natural sources is continuing. As of mid-2002, over 100 plant-derived sweet compounds of 20 major structural types had been reported, and were isolated from more than 25 different families of green plants. Several of these highly sweet natural products are marketed as sweeteners or flavoring agents in some countries as pure compounds, compound mixtures, or refined extracts. These highly sweet natural substances are reviewed herein.

  10. A New Compound from Swertia cincta

    Institute of Scientific and Technical Information of China (English)

    Wen-xing Liu; Qian Tian; Cui Yang; Hai-yan Wu; Shang-xiu Li; Gan-peng Li

    2016-01-01

    Objective To study the chemical constituents from the whole plant of Swertia cincta.Methods The chemical constituents were purified by chromatographic methods such as silica gel column and Sephadex LH-20.The structures of these compounds were elucidated by MS,IR,and NMR analyses.Results Two compounds were isolated from S.cincta.Conclusion Compound 1 is a new compound named swercinctlactone A.Compound 2 is identified as (±)-gentiolactone and its configuration is confirmed by single crystal X-ray diffraction and optical specific rotation.

  11. Promiscuity progression of bioactive compounds over time.

    Science.gov (United States)

    Hu, Ye; Jasial, Swarit; Bajorath, Jürgen

    2015-01-01

    In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets. To study promiscuity progression of bioactive compounds in detail, nearly 1 million compounds and more than 5.2 million activity records were analyzed. Compound sets were assembled by applying different data confidence criteria and selecting compounds with activity histories over many years. On the basis of release dates, compounds and activity records were organized on a time course, which ultimately enabled monitoring data growth and promiscuity progression over nearly 40 years, beginning in 1976. Surprisingly low degrees of promiscuity were consistently detected for all compound sets and there were only small increases in promiscuity over time. In fact, most compounds had a constant degree of promiscuity, including compounds with an activity history of 10 or 20 years. Moreover, during periods of massive data growth, beginning in 2007, promiscuity degrees also remained constant or displayed only minor increases, depending on the activity data confidence levels. Considering high-confidence data, bioactive compounds currently interact with 1.5 targets on average, regardless of their origins, and display essentially constant degrees of promiscuity over time. Taken together, our findings provide expectation values for promiscuity progression and magnitudes among bioactive compounds as activity data further grow.

  12. Veterinary Compounding: Regulation, Challenges, and Resources.

    Science.gov (United States)

    Davidson, Gigi

    2017-01-10

    The spectrum of therapeutic need in veterinary medicine is large, and the availability of approved drug products for all veterinary species and indications is relatively small. For this reason, extemporaneous preparation, or compounding, of drugs is commonly employed to provide veterinary medical therapies. The scope of veterinary compounding is broad and focused primarily on meeting the therapeutic needs of companion animals and not food-producing animals in order to avoid human exposure to drug residues. As beneficial as compounded medical therapies may be to animal patients, these therapies are not without risks, and serious adverse events may occur from poor quality compounds or excipients that are uniquely toxic when administered to a given species. Other challenges in extemporaneous compounding for animals include significant regulatory variation across the global veterinary community, a relative lack of validated compounding formulas for use in animals, and poor adherence by compounders to established compounding standards. The information presented in this article is intended to provide an overview of the current landscape of compounding for animals; a discussion on associated benefits, risks, and challenges; and resources to aid compounders in preparing animal compounds of the highest possible quality.

  13. Organic compounds in carbonaceous meteorites.

    Science.gov (United States)

    Sephton, Mark A

    2002-06-01

    The carbonaceous chondrite meteorites are fragments of asteroids that have remained relatively unprocessed since the formation of the solar system 4.6 billion years ago. These carbon-rich objects contain a variety of extraterrestrial organic molecules that constitute a record of chemical evolution prior to the origin of life. Compound classes include aliphatic hydrocarbons, aromatic hydrocarbons, amino acids, carboxylic acids, sulfonic acids, phosphonic acids, alcohols, aldehydes, ketones, sugars, amines, amides, nitrogen heterocycles, sulfur heterocycles and a relatively abundant high molecular weight macromolecular material. Structural and stable isotopic characteristics suggest that a number of environments may have contributed to the organic inventory, including interstellar space, the solar nebula and the asteroidal meteorite parent body. This review covers work published between 1950 and the present day and cites 193 references.

  14. Zirconium Compound with Boundless Prospects

    Institute of Scientific and Technical Information of China (English)

    LUO FangCheng; ZHENG JingYi; LV WenGuang; CHEN ZhongXi; WU FengFeng

    2001-01-01

    @@ Zirconium compound has a wide-ranging use in the field of high and new technology. It is published in 2000'CHINA HIGH AND NEW TECHNOLOGY PRODUCT CATALOGUE , CHINA HIGH and NEW TECHNOLOGY PRODUCT EXPORT CATALOGUE, and INTERNATIONAL KEY AND URGING DEVELOPMENT CATALOGUE OF PROPERTY, COMMODITY AND TECHNOLNGY Zirconia with the characteristic of electricity, magnetism, optics and mechanies, has good advantageous in making configurable ceramic and functional ceramic, such as band filter, resonator, buzzer and other electronic elements; optical lens, upholster crystallize glasses and other glass; synthetic tooth, synthetic bones and other biological ceramic products; new type axletree, engine, valve, airproof loop and other components of internal-combustion engine and steamship; ferrozirconium and other high temperature ceramic paint. It become a new material which has a wide-ranging use in the field of electron, spaceflight, aerospace, metallurgy, chemistry, biology, medicine and etc.

  15. Zirconium Compound with Boundless Prospects

    Institute of Scientific and Technical Information of China (English)

    LUO; FangCheng

    2001-01-01

    Zirconium compound has a wide-ranging use in the field of high and new technology. It is published in 2000'CHINA HIGH AND NEW TECHNOLOGY PRODUCT CATALOGUE , CHINA HIGH and NEW TECHNOLOGY PRODUCT EXPORT CATALOGUE, and INTERNATIONAL KEY AND URGING DEVELOPMENT CATALOGUE OF PROPERTY, COMMODITY AND TECHNOLNGY Zirconia with the characteristic of electricity, magnetism, optics and mechanies, has good advantageous in making configurable ceramic and functional ceramic, such as band filter, resonator, buzzer and other electronic elements; optical lens, upholster crystallize glasses and other glass; synthetic tooth, synthetic bones and other biological ceramic products; new type axletree, engine, valve, airproof loop and other components of internal-combustion engine and steamship; ferrozirconium and other high temperature ceramic paint. It become a new material which has a wide-ranging use in the field of electron, spaceflight, aerospace, metallurgy, chemistry, biology, medicine and etc.  ……

  16. New permanent magnets; manganese compounds.

    Science.gov (United States)

    Coey, J M D

    2014-02-12

    The exponential growth of maximum energy product that prevailed in the 20th century has stalled, leaving a market dominated by two permanent magnet materials, Nd2Fe14B and Ba(Sr)Fe12O19, for which the maximum theoretical energy products differ by an order of magnitude (515 kJ m(-3) and 45 kJ m(-3), respectively). Rather than seeking to improve on optimized Nd-Fe-B, it is suggested that some research efforts should be devoted to developing appropriately priced alternatives with energy products in the range 100-300 kJ m(-3). The prospects for Mn-based hard magnetic materials are discussed, based on known Mn-based compounds with the tetragonal L10 or D022 structure or the hexagonal B81 structure.

  17. Prioritizing pesticide compounds for analytical methods development

    Science.gov (United States)

    Norman, Julia E.; Kuivila, Kathryn M.; Nowell, Lisa H.

    2012-01-01

    The U.S. Geological Survey (USGS) has a periodic need to re-evaluate pesticide compounds in terms of priorities for inclusion in monitoring and studies and, thus, must also assess the current analytical capabilities for pesticide detection. To meet this need, a strategy has been developed to prioritize pesticides and degradates for analytical methods development. Screening procedures were developed to separately prioritize pesticide compounds in water and sediment. The procedures evaluate pesticide compounds in existing USGS analytical methods for water and sediment and compounds for which recent agricultural-use information was available. Measured occurrence (detection frequency and concentrations) in water and sediment, predicted concentrations in water and predicted likelihood of occurrence in sediment, potential toxicity to aquatic life or humans, and priorities of other agencies or organizations, regulatory or otherwise, were considered. Several existing strategies for prioritizing chemicals for various purposes were reviewed, including those that identify and prioritize persistent, bioaccumulative, and toxic compounds, and those that determine candidates for future regulation of drinking-water contaminants. The systematic procedures developed and used in this study rely on concepts common to many previously established strategies. The evaluation of pesticide compounds resulted in the classification of compounds into three groups: Tier 1 for high priority compounds, Tier 2 for moderate priority compounds, and Tier 3 for low priority compounds. For water, a total of 247 pesticide compounds were classified as Tier 1 and, thus, are high priority for inclusion in analytical methods for monitoring and studies. Of these, about three-quarters are included in some USGS analytical method; however, many of these compounds are included on research methods that are expensive and for which there are few data on environmental samples. The remaining quarter of Tier 1

  18. High-Strength, Superelastic Compounds

    Science.gov (United States)

    Stanford, Malcolm; Noebe, Ronald; Dellacorte, Christopher; Bigelow, Glen; Thomas, Fransua

    2013-01-01

    In a previous disclosure, the use of 60- NiTiNOL, an ordered intermetallic compound composed of 60 weight percent nickel and 40 weight percent titanium, was investigated as a material for advanced aerospace bearings due to its unique combination of physical properties. Lessons learned during the development of applications for this material have led to the discovery that, with the addition of a ternary element, the resulting material can be thermally processed at a lower temperature to attain the same desirable hardness level as the original material. Processing at a lower temperature is beneficial, not only because it reduces processing costs from energy consumption, but because it also significantly reduces the possibility of quench cracking and thermal distortion, which have been problematic with the original material. A family of ternary substitutions has been identified, including Hf and Zr in various atomic percentages with varying concentrations of Ni and Ti. In the present innovation, a ternary intermetallic compound consisting of 57.6 weight percent Ni, 39.2 weight percent Ti, and 3.2 weight percent Hf (54Ni-45Ti-1Hf atomic percent) was prepared by casting. In this material, Hf substitutes for some of the Ti atoms in the material. In an alternate embodiment of the innovation, Zr, which is close in chemical behavior to Hf, is used as the substitutional element. With either substitution, the solvus temperature of the material is reduced, and lower temperatures can be used to obtain the necessary hardness values. The advantages of this innovation include the ability to solution-treat the material at a lower temperature and still achieve the required hardness for bearings (at least 50 Rockwell C) and superelastic behavior with recoverable strains greater than 2%. Most structural alloys will not return to their original shape after being deformed as little as 0.2% (a tenth of that possible with superelastic materials like 60 NiTiNOL). Because lower temperatures

  19. Organic electronic devices using phthalimide compounds

    Science.gov (United States)

    Hassan, Azad M.; Thompson, Mark E.

    2010-09-07

    Organic electronic devices comprising a phthalimide compound. The phthalimide compounds disclosed herein are electron transporters with large HOMO-LUMO gaps, high triplet energies, large reduction potentials, and/or thermal and chemical stability. As such, these phthalimide compounds are suitable for use in any of various organic electronic devices, such as OLEDs and solar cells. In an OLED, the phthalimide compounds may serve various functions, such as a host in the emissive layer, as a hole blocking material, or as an electron transport material. In a solar cell, the phthalimide compounds may serve various functions, such as an exciton blocking material. Various examples of phthalimide compounds which may be suitable for use in the present invention are disclosed.

  20. Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds

    Directory of Open Access Journals (Sweden)

    Joel R. Coats

    2000-04-01

    Full Text Available The insecticidal activities of several cyanohydrins, cyanohydrin esters and monoterpenoid esters (including three monoterpenoid esters of a cyanohydrin were evaluated. Topical toxicity to Musca domestica L. adults was examined, and testing of many compounds at 100 mg/fly resulted in 100% mortality. Topical LD50 values of four compounds for M. domestica were calculated. Testing of many of the reported compounds to brine shrimp (Artemia franciscana Kellog resulted in 100% mortality at 10 ppm, and two compounds caused 100% mortality at 1 ppm. Aquatic LC50 values were calculated for five compounds for larvae of the yellow fever mosquito (Aedes aegypti (L.. Monoterpenoid esters were among the most toxic compounds tested in topical and aquatic bioassays.

  1. Compound cryopump for fusion reactors

    CERN Document Server

    Kovari, M; Shephard, T

    2013-01-01

    We reconsider an old idea: a three-stage compound cryopump for use in fusion reactors such as DEMO. The helium "ash" is adsorbed on a 4.5 K charcoal-coated surface, while deuterium and tritium are adsorbed at 15-22 K on a second charcoal-coated surface. The helium is released by raising the first surface to ~30 K. In a separate regeneration step, deuterium and tritium are released at ~110 K. In this way, the helium can be pre-separated from other species. In the simplest design, all three stages are in the same vessel, with a single valve to close the pump off from the tokamak during regeneration. In an alternative design, the three stages are in separate vessels, connected by valves, allowing the stages to regenerate without interfering with each other. The inclusion of the intermediate stage would not affect the overall pumping speed significantly. The downstream exhaust processing system could be scaled down, as much of the deuterium and tritium could be returned directly to the reactor. This could reduce ...

  2. High performance compound semiconductor SPAD arrays

    Science.gov (United States)

    Harmon, Eric S.; Naydenkov, Mikhail; Bowling, Jared

    2016-05-01

    Aggregated compound semiconductor single photon avalanche diode (SPAD) arrays are emerging as a viable alternative to the silicon photomultiplier (SiPM). Compound semiconductors have the potential to surpass SiPM performance, potentially achieving orders of magnitude lower dark count rates and improved radiation hardness. New planar processing techniques have been developed to enable compound semiconductor SPAD devices to be produced with pixel pitches of 11 - 25 microns, with thousands of SPADs per array.

  3. Potent antifouling compounds produced by marine Streptomyces

    KAUST Repository

    Xu, Ying

    2010-02-01

    Biofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure-activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. © 2009 Elsevier Ltd. All rights reserved.

  4. Antimicrobial Action of Compounds from Marine Seaweed

    Directory of Open Access Journals (Sweden)

    María José Pérez

    2016-03-01

    Full Text Available Seaweed produces metabolites aiding in the protection against different environmental stresses. These compounds show antiviral, antiprotozoal, antifungal, and antibacterial properties. Macroalgae can be cultured in high volumes and would represent an attractive source of potential compounds useful for unconventional drugs able to control new diseases or multiresistant strains of pathogenic microorganisms. The substances isolated from green, brown and red algae showing potent antimicrobial activity belong to polysaccharides, fatty acids, phlorotannins, pigments, lectins, alkaloids, terpenoids and halogenated compounds. This review presents the major compounds found in macroalga showing antimicrobial activities and their most promising applications.

  5. Electronic structure and magnetism in actinide compounds

    Energy Technology Data Exchange (ETDEWEB)

    Durakiewicz, T. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)]. E-mail: tomasz@lanl.gov; Joyce, J.J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Lander, G.H. [JRC, Institute of Transuranium Elements, Postfach 2340, 76125 Karlsruhe (Germany); Olson, C.G. [Ames Laboratory, Iowa State University, Ames, Iowa 5011 (United States); Butterfield, M.T. [Lawrence Livermoore National Laboratory, Livermoore, CA 94550 (United States); Guziewicz, E. [Institute of Physics, Polish Academy of Sciences, 02-668 Warsaw (Poland); Batista, C.D. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Arko, A.J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Morales, L. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Mattenberger, K. [Laboratorium fur Festkorperphysik, ETH, CH-8093, Zurich (Switzerland); Vogt, O. [Laboratorium fur Festkorperphysik, ETH, CH-8093, Zurich (Switzerland)

    2006-05-01

    A close relationship between electronic structure and magnetic properties is observed in actinide compounds. The exact nature of this relationship is under investigation. We present examples of a direct link between electronic structure and ordered magnetic moment and/or magnetization. Specifically, results obtained for cubic U, Np and Pu compounds and quasi-2D U compounds are be presented. In the case of cubic compounds, a direct relationship between binding energy of valence band features and magnetic moment will be discussed. A Stoner-like mechanism and simple mean-field explanation is proposed for ferromagnetic UTe.

  6. Hydrodesulfurization catalysis by Chevrel phase compounds

    Science.gov (United States)

    McCarty, Kevin F.; Schrader, Glenn L.

    1985-12-24

    A process is disclosed for the hydrodesulfurization of sulfur-containing hydrocarbon fuel with reduced ternary molybdenum sulfides, known as Chevrel phase compounds. Chevrel phase compounds of the general composition M.sub.x Mo.sub.6 S.sub.8, with M being Ho, Pb, Sn, Ag, In, Cu, Fe, Ni, or Co, were found to have hydrodesulfurization activities comparable to model unpromoted and cobalt-promoted MoS.sub.2 catalysts. The most active catalysts were the "large" cation compounds (Ho, Pb, Sn), and the least active catalysts were the "small" cation compounds (Cu, Fe, Ni, Co.).

  7. CHARACTERIZATION OF RUTIN-CYCLODEXTRIN INCLUSION COMPOUNDS

    Directory of Open Access Journals (Sweden)

    Andreia Corciovă

    2011-12-01

    Full Text Available The objectives of this study were to examine the potential of beta-cyclodextrin to improve the solubility of rutin and obtain inclusion compounds that were analyzed by different techniques: UV-Vis, IR spectroscopy, thermal analysis. The presence of β-cyclodextrin raises the content of rutin in water. The inclusion compounds were prepared by dry mixing, complexation in semisolid and liquid medium in 1:2 molar ratio rutin - β-cyclodextrin. The UV-Vis and IR analysis demonstrated the obtaining of inclusion compounds and the thermal analysis show that these compounds are more stable than the parent substance.

  8. Investigations on organogermanium compounds XII. Reactions of trialkylgermylalkalimetal compounds in hexamethylphosphoric triamide (HMPT) with some inorganic and organic compounds

    NARCIS (Netherlands)

    Bulten, E.J.; Noltes, J.G.

    1971-01-01

    Trialkylgermyl alkali metal compounds in HMPT have been found to be highly reactive nucleophiles. Reactions with some inorganic and organic compounds, such as oxygen, carbon dioxide, inorganic and orgaanic halides, aldehydes, ketones, epoxides and lactones are described. Several new carbon-functiona

  9. Exploring marine resources for bioactive compounds.

    Science.gov (United States)

    Kiuru, Paula; DʼAuria, M Valeria; Muller, Christian D; Tammela, Päivi; Vuorela, Heikki; Yli-Kauhaluoma, Jari

    2014-09-01

    Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, it is possible to successfully collect, isolate and classify marine organisms, such as bacteria, fungi, micro- and macroalgae, cyanobacteria, and marine invertebrates from the oceans and seas globally. Extracts and purified compounds of these organisms can be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral, antibacterial, and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms and biotechnological processes for selected compounds can be developed, as well as biosensors for monitoring the target compounds. The (semi)synthetic modification of marine-based bioactive compounds produces their new derivatives, structural analogs and mimetics that could serve as hit or lead compounds and be used to expand compound libraries based on marine natural products. The research innovations can be targeted for industrial product development in order to improve the growth and productivity of marine biotechnology. Marine research aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity. Marine research is expected to offer novel marine-based lead compounds for industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosmetic, agrochemical, food processing, material and biosensor applications.

  10. Crystal structure analysis of intermetallic compounds

    Science.gov (United States)

    Conner, R. A., Jr.; Downey, J. W.; Dwight, A. E.

    1968-01-01

    Study concerns crystal structures and lattice parameters for a number of new intermetallic compounds. Crystal structure data have been collected on equiatomic compounds, formed between an element of the Sc, Ti, V, or Cr group and an element of the Co or Ni group. The data, obtained by conventional methods, are presented in an easily usable tabular form.

  11. Analysis of phenolic compounds for poultry feeds

    Science.gov (United States)

    Phenolic compounds have generated significant interest recently as feed additives that can impart bioactive characteristics such as anti-oxidant, anti-microbial, and anti-fungal properties to a feed formulation [1-2]. Such natural compounds may offer some preventive benefit to the routine administra...

  12. Bacterial formation of hydroxylated aromatic compounds.

    NARCIS (Netherlands)

    Tweel, van den W.J.J.

    1988-01-01

    As stated in the introduction of this thesis, hydroxylated aromatic compounds in general are of great importance for various industries as for instance pharmaceutical, agrochemical and petrochemical industries. Since these compounds can not be isolated in sufficient amounts from natural resources, t

  13. Preparation of Several Tritiated Macromolecular Compounds

    Institute of Scientific and Technical Information of China (English)

    CHEN; Bao-jun; YU; Ning-wen; FAN; Cai-yun

    2015-01-01

    Tritiated compounds are widely used in drug metabolism and pharmacokinetic studies.They play an important role in new drug research.Isotope exchange method is a very effective method for the preparation of tritiated compounds.It is particularly suitable for labeling macromolecule

  14. Amino acid modifiers in guayule rubber compounds

    Science.gov (United States)

    Tire producers are increasingly interested in biobased materials, including rubber but also as compounding chemicals. An alternative natural rubber for tire use is produced by guayule, a woody desert shrub native to North America. Alternative compounding chemicals include naturally-occurring amino a...

  15. Semantics vs Pragmatics of a Compound Word

    Science.gov (United States)

    Smirnova, Elena A.; Biktemirova, Ella I.; Davletbaeva, Diana N.

    2016-01-01

    This paper is devoted to the study of correlation between semantic and pragmatic potential of a compound word, which functions in informal speech, and the mechanisms of secondary nomination, which realizes the potential of semantic-pragmatic features of colloquial compounds. The relevance and the choice of the research question is based on the…

  16. Lattice anisotropy in uranium ternary compounds

    DEFF Research Database (Denmark)

    Maskova, S.; Adamska, A.M.; Havela, L.

    2012-01-01

    Several U-based intermetallic compounds (UCoGe, UNiGe with the TiNiSi structure type and UNiAl with the ZrNiAl structure type) and their hydrides were studied from the point of view of compressibility and thermal expansion. Confronted with existing data for the compounds with the ZrNiAl structure...

  17. The mechanocaloric potential of spin crossover compounds

    OpenAIRE

    Sandeman, K. G.

    2016-01-01

    We present a first evaluation of the potential for spin crossover (SCO) compounds to be considered as a new class of giant mechanocaloric effect material. From literature data on the variation of the spin crossover temperature with pressure, we estimate the maximum available adiabatic temperature change for several compounds and the relatively low pressures that may be required to observe these effects.

  18. Hybrid Compounding in New Zealand English

    Science.gov (United States)

    Degani, Marta; Onysko, Alexander

    2010-01-01

    This study investigates hybrid compound formation of Maori and English terms in present day New Zealand English (NZE). On the background of Maori and English language contact, the phenomenon of hybrid compounding emerges as a process that, on the one hand, symbolizes the vitality of the Maori element in NZE and, on the other hand, marks the…

  19. Ambient Air Monitoring for Sulfur Compounds

    Science.gov (United States)

    Forrest, Joseph; Newman, Leonard

    1973-01-01

    A literature review of analytical techniques available for the study of compounds at low concentrations points up some of the areas where further research is needed. Compounds reviewed are sulfur dioxide, sulfuric acid, ammonium sulfate and bisulfate, metal sulfates, hydrogen sulfide, and organic sulfides. (BL)

  20. Bioactive compounds in whole grain wheat

    NARCIS (Netherlands)

    Mateo Anson, N.

    2010-01-01

    Bread can be healthier! Consuming whole-grain foods can prevent cardiovascular diseases, type-2 diabetes and metabolic syndrome. This is due to bioactive compounds in whole grain, such as antioxidants and anti-inflammatory compounds. We found that the different fractions of a wheat grain vary much i

  1. Heterogeneous photocatalytic reactions of sulfur aromatic compounds.

    Science.gov (United States)

    Samokhvalov, Alexander

    2011-11-18

    Sulfur aromatic compounds, such as mono-, di-, tri-, and tetraalkyl-substituted thiophene, benzothiophenes, dibenzothiophenes, are the molecular components of many fossils (petroleum, oil shale, tar sands, bitumen). Structural units of natural, cross-linked heteroaromatic polymers present in brown coals, turf, and soil are similar to those of sulfur aromatic compounds. Many sulfur aromatic compounds are found in the streams of petroleum refining and upgrading (naphthas, gas oils) and in the consumer products (gasoline, diesel, jet fuels, heating fuels). Besides fossils, the structural fragments of sulfur aromatic compounds are present in molecules of certain organic semiconductors, pesticides, small molecule drugs, and in certain biomolecules present in human body (pheomelanin pigments). Photocatalysis is the frontier area of physical chemistry that studies chemical reactions initiated by absorption of photons by photocatalysts, that is, upon electronic rather than thermal activation, under "green" ambient conditions. This review provides systematization and critical review of the fundamental chemical and physicochemical information on heterogeneous photocatalysis of sulfur aromatic compounds accumulated in the last 20-30 years. Specifically, the following topics are covered: physicochemical properties of sulfur aromatic compounds, major classes of heterogeneous photocatalysts, mechanisms and reactive intermediates of photocatalytic reactions of sulfur aromatic compounds, and the selectivity of these reactions. Quantum chemical calculations of properties and structures of sulfur aromatic compounds, their reactive intermediates, and the structure of adsorption complexes formed on the surface of the photocatalysts are also discussed.

  2. Two new compounds from Ganoderma lucidum.

    Science.gov (United States)

    Wang, Xin-Fang; Yan, Yong-Ming; Wang, Xin-Long; Ma, Xiu-Jing; Fu, Xue-Yan; Cheng, Yong-Xian

    2015-01-01

    Two pairs of new enantiomers, lucidulactones A and B (1 and 2), and two known compounds were isolated from Ganoderma lucidum. Their structures were determined by means of spectroscopic methods. The chiral HPLC was used to separate the ( - )- and (+)-antipodes of the new compounds.

  3. Volatile organic compound emissions from silage systems

    Science.gov (United States)

    As a precursor to smog, emission of volatile organic compounds (VOCs) to the atmosphere is an environmental concern in some regions. The major source from farms is silage, with emissions coming from the silo face, mixing wagon, and feed bunk. The major compounds emitted are alcohols with other impor...

  4. Bis(1,3-dithiole) Compounds

    DEFF Research Database (Denmark)

    Andersen, Jan Rud; Engler, E. M.; Green, D. C.;

    1977-01-01

    There is described the preparation of bis-1,3-dithiole compounds (I) which are key synthetic precursors for the preparation of new polymeric metal bis(dithiolene) (i.e., II) and tetrathiafulvalene compounds (i.e., III): (Image Omitted)...

  5. Chalcones: compounds possessing a diversity in applications

    OpenAIRE

    2012-01-01

    Chalcones are a class of α, β- unsaturated carbonyl compounds that form the central core for a variety of naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. Besides their various pharmacological activities, chalcones have been explored for different optical applications including second harmonic generation materials in non- linear optics, fluorescent probe for sensing different molecules.

  6. Integrated modelling of two xenobiotic organic compounds

    DEFF Research Database (Denmark)

    Lindblom, Erik Ulfson; Gernaey, K.V.; Henze, Mogens

    2006-01-01

    This paper presents a dynamic mathematical model that describes the fate and transport of two selected xenobiotic organic compounds (XOCs) in a simplified representation. of an integrated urban wastewater system. A simulation study, where the xenobiotics bisphenol A and pyrene are used as reference...... rate and concentration profiles. The wet weather day induces resuspension of stored sediments, which increases the pollutant load on the downstream system. The potential of the model to elucidate important phenomena related to origin and fate of the model compounds is demonstrated....... compounds, is carried out. Sorption and specific biological degradation processes are integrated with standardised water process models to model the fate of both compounds. Simulated mass flows of the two compounds during one dry weather day and one wet weather day are compared for realistic influent flow...

  7. Methods of making organic compounds by metathesis

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Timothy W.; Kaido, Hiroki; Lee, Choon Woo; Pederson, Richard L.; Schrodi, Yann; Tupy, Michael John

    2015-09-01

    Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

  8. Potent acetylcholinesterase inhibitory compounds from Myristica fragrans.

    Science.gov (United States)

    Cuong, To Dao; Hung, Tran Manh; Han, Hyoung Yun; Roh, Hang Sik; Seok, Ji-Hyeon; Lee, Jong Kwon; Jeong, Ja Young; Choi, Jae Sue; Kim, Jeong Ah; Min, Byung Sun

    2014-04-01

    The anti-cholinesterase activity was evaluated of the ethyl acetate fraction of the methanol extract of Myristica fragrans Houtt (Myristicaceae) seeds and of compounds isolated from it by various chromatographic techniques. The chemical structures of the compounds were determined from spectroscopic analyses (NMR data). Thirteen compounds (1-13) were isolated and identified. Compound 8 { [(7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl]benzene-2,4-diol) showed the most effective activity with an IC50 value of 35.1 microM, followed by compounds 2 [(8R,8'S)-7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane] and 11 (malabaricone C) with IC50 values of 42.1 and 44.0 pM, respectively. This is the first report of significant anticholinesterase properties of M. fragrans seeds. The findings demonstrate that M. fragrans could be used beneficially in the treatment of Alzheimer's disease.

  9. Depyrogenation options for the compounding cleanroom.

    Science.gov (United States)

    Weller, Tom; Bell, Jeff; Dullinger, Roger; Allen, Vern; Anthenat, Bruce

    2014-01-01

    Compounding pharmacies, especially those awarded 503B status under the U.S. Federal Food, Drug, and Cosmetic Act that resulted from the Drug Quality and Security Act, must meet increasingly strict standards for the preparation of sterile formulations. Depyrogenating the containers and tools used in such compounding is essential to meeting those standards and ensuring patient safety. Although pyrogens are relatively thermally stable, treating aseptic-compounding glassware and implements in a dry-heat oven or tunnel is the most common method of depyrogenation. Depyrogenation tunnels are used at larger facilities in which automation and a higher throughput can justify the cost of that equipment, but a small batch oven is an inexpensive and appropriate solution to meeting sterilization and depyrogenation requirements in a smaller compounding pharmacy. In this article, we discuss the appropriate use of depyrogenation ovens and tunnels, compare those types of equipment, and describe the selection and use of a cleanroom oven in a compounding pharmacy.

  10. Water-soluble constituents of caraway: aromatic compound, aromatic compound glucoside and glucides.

    Science.gov (United States)

    Matsumura, Tetsuko; Ishikawa, Toru; Kitajima, Junichi

    2002-10-01

    From the water-soluble portion of the methanolic extract of caraway (fruit of Carum carvi L.), an aromatic compound, an aromatic compound glucoside and a glucide were isolated together with 16 known compounds. Their structures were clarified as 2-methoxy-2-(4'-hydroxyphenyl)ethanol, junipediol A 2-O-beta-D-glucopyranoside and L-fucitol, respectively.

  11. Biodegradable compounds: Rheological, mechanical and thermal properties

    Science.gov (United States)

    Nobile, Maria Rossella; Lucia, G.; Santella, M.; Malinconico, M.; Cerruti, P.; Pantani, R.

    2015-12-01

    Recently great attention from industry has been focused on biodegradable polyesters derived from renewable resources. In particular, PLA has attracted great interest due to its high strength and high modulus and a good biocompatibility, however its brittleness and low heat distortion temperature (HDT) restrict its wide application. On the other hand, Poly(butylene succinate) (PBS) is a biodegradable polymer with a low tensile modulus but characterized by a high flexibility, excellent impact strength, good thermal and chemical resistance. In this work the two aliphatic biodegradable polyesters PBS and PLA were selected with the aim to obtain a biodegradable material for the industry of plastic cups and plates. PBS was also blended with a thermoplastic starch. Talc was also added to the compounds because of its low cost and its effectiveness in increasing the modulus and the HDT of polymers. The compounds were obtained by melt compounding in a single screw extruder and the rheological, mechanical and thermal properties were investigated. The properties of the two compounds were compared and it was found that the values of the tensile modulus and elongation at break measured for the PBS/PLA/Talc compound make it interesting for the production of disposable plates and cups. In terms of thermal resistance the compounds have HDTs high enough to contain hot food or beverages. The PLA/PBS/Talc compound can be, then, considered as biodegradable substitute for polystyrene for the production of disposable plates and cups for hot food and beverages.

  12. Phenolic compounds in Ross Sea water

    Science.gov (United States)

    Zangrando, Roberta; Barbaro, Elena; Gambaro, Andrea; Barbante, Carlo; Corami, Fabiana; Kehrwald, Natalie; Capodaglio, Gabriele

    2016-04-01

    Phenolic compounds are semi-volatile organic compounds produced during biomass burning and lignin degradation in water. In atmospheric and paleoclimatic ice cores studies, these compounds are used as biomarkers of wood combustion and supply information on the type of combusted biomass. Phenolic compounds are therefore indicators of paleoclimatic interest. Recent studies of Antarctic aerosols highlighted that phenolic compounds in Antarctica are not exclusively attributable to biomass burning but also derive from marine sources. In order to study the marine contribution to aerosols we developed an analytical method to determine the concentration of vanillic acid, vanillin, p-coumaric acid, syringic acid, isovanillic acid, homovanillic acid, syringaldehyde, acetosyringone and acetovanillone present in dissolved and particle phases in Sea Ross waters using HPLC-MS/MS. The analytical method was validated and used to quantify phenolic compounds in 28 sea water samples collected during a 2012 Ross Sea R/V cruise. The observed compounds were vanillic acid, vanillin, acetovanillone and p-coumaric acid with concentrations in the ng/L range. Higher concentrations of analytes were present in the dissolved phase than in the particle phase. Sample concentrations were greatest in the coastal, surficial and less saline Ross Sea waters near Victoria Land.

  13. [Functional analysis of bioactive natural compounds using monoclonal antibodies against natural compounds].

    Science.gov (United States)

    Uto, Takuhiro

    2014-01-01

    Herbal medicines have recently attracted much importance owing to the rising interest in their health benefits. Hence, further elucidation of the functions and mechanisms of these natural compounds is necessary. Our laboratory has established more than 30 kinds of monoclonal antibodies (MAbs) against bioactive natural compounds. Moreover, we have developed highly sensitive measurement systems for natural compounds, such as enzyme-linked immunosorbent assay (ELISA) and eastern blotting using MAbs. To expand the application of these MAbs to the functional analysis of natural compounds, we established a new approach for the isolation of the target compound from plant extracts using an immunoaffinity column conjugated with an anti-natural compound MAb. Through one-step purification using a MAb-conjugated immunoaffinity column, we have succeeded in preparing a knockout (KO) extract containing all components except the target compound, used as a hapten. Furthermore, we examined the pharmacological effects of the KO extract to identify the precise roles of the bioactive compound in the plant extract. To confirm another beneficial use of MAbs, we investigated the cellular localization and target molecules of natural compounds by immunocytochemistry (ICC) and Western blotting using MAbs. Our results demonstrated that MAbs clearly determined the cellular localization and target molecules of the natural compounds. These approaches may make it possible to determine the potential functions and target molecules of bioactive natural compounds in herbal medicines.

  14. Method for the detection of aquaretic compounds

    DEFF Research Database (Denmark)

    2003-01-01

    Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquap...... of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions....

  15. Two novel compounds from Paeonia suffructicosa.

    Science.gov (United States)

    Lin, H C; Ding, H Y; Wu, Y C

    1998-03-01

    A new hexacyclic triterpenoid, mudanpinoic acid A (1), and a new gallic acid glycoside, mudanoside B (2), along with nine known compounds--benzoic acid, resacetophenone, paeoniflorigenone, beta-sitosterol, betulinic acid, oleanoic acid, quercetin, beta-sitosterol-beta-D-glucoside, and trans-caffeic acid stearyl ester-were isolated from the dried root cortex of Paeonia suffruticosa. The structures of the novel compounds were elucidated on the basis of spectral methods, and that of compound 1 was confirmed by X-ray crystallographic analysis.

  16. Nonlinear system compound inverse control method

    Institute of Scientific and Technical Information of China (English)

    Yan ZHANG; Zengqiang CHEN; Peng YANG; Zhuzhi YUAN

    2005-01-01

    A compound neural network is utilized to identify the dynamic nonlinear system.This network is composed of two parts: one is a linear neural network,and the other is a recurrent neural network.Based on the inverse theory a compound inverse control method is proposed.The controller has also two parts:a linear controller and a nonlinear neural network controller.The stability condition of the closed-loop neural network-based compound inverse control system is demonstrated based on the Lyapunov theory.Simulation studies have shown that this scheme is simple and has good control accuracy and robustness.

  17. Compound leaf development in model plant species.

    Science.gov (United States)

    Bar, Maya; Ori, Naomi

    2015-02-01

    Plant leaves develop in accordance with a common basic program, which is flexibly adjusted to the species, developmental stage and environment. Two key stages of leaf development are morphogenesis and differentiation. In the case of compound leaves, the morphogenesis stage is prolonged as compared to simple leaves, allowing for the initiation of leaflets. Here, we review recent advances in the understanding of how plant hormones and transcriptional regulators modulate compound leaf development, yielding a substantial diversity of leaf forms, focusing on four model compound leaf organisms: cardamine (Cardamine hirsuta), tomato (Solanum lycopersicum), medicago (Medicago truncatula) and pea (Pisum sativum).

  18. Periodicity effects on compound guided waves

    Science.gov (United States)

    Chiadini, Francesco; Fiumara, Vincenzo; Scaglione, Antonio; Lakhtakia, Akhlesh

    2016-09-01

    Surface waves of different types can be compounded when a homogeneous layer is sandwiched between two half spaces filled with dissimilar periodically non-homogeneous dielectric materials and the intermediate layer is sufficiently thin. We solved the boundary-value problem for compound waves guided by a layer of a homogeneous and isotropic (metal or dielectric) material sandwiched between a structurally chiral material (SCM) and a periodically multi-layered isotropic dielectric material. We found that the periodicity of the SCM is crucial to excite a multiplicity of compound guided waves with strong coupling between the two interfaces.

  19. A new caffeate compound from Nardostachys chinensis.

    Science.gov (United States)

    Chen, Ying-peng; Wang, Zhong-ping; Zheng, Hong-hong; Xu, Yan-tong; Zhu, Yani; Zhang, Peng; Wu, Hong-hua

    2016-01-01

    A new caffeate compound, (E)-erythro-syringylglyceryl caffeate (1), was isolated from the roots and rhizomes of Nardostachys chinensis Batal., together with nine known phenolic compounds, including (+)-licarin A (2), naringenin 4', 7-dimethyl ether (3), pinoresinol-4-O-β-D-glucoside (4), caraphenol A (5), Z-miyabenol C (6), protocatechuic acid (7), caffeic acid (8), gallic acid (9) and vanillic acid (10). Their chemical structures were elucidated on the basis of spectroscopic data and physicochemical properties. Furthermore, this is the first report of compounds 2, 5 and 6 from Nardostachys genus.

  20. Microbial production of scent and flavor compounds.

    Science.gov (United States)

    Carroll, Austin L; Desai, Shuchi H; Atsumi, Shota

    2016-02-01

    Scents and flavors like those of fresh oranges are no longer limited to just the natural product. Fruit, flower, and essential oil scents have found place in cosmetics, soaps, candles, and food amongst many common household products. With their increasing global demand and difficulty in extractation from the natural source, alternative methods of their production are being sought. One sustainable method is to employ microorganisms for the production of these high value compounds. With the tools of metabolic engineering, microorganisms can be modified to produce compounds such as esters, terpenoids, aldehydes, and methyl ketones. Approaches and challenges for the production of these compounds from microbial hosts are discussed in this review.

  1. Endocannabinoids, Related Compounds and Their Metabolic Routes

    Directory of Open Access Journals (Sweden)

    Filomena Fezza

    2014-10-01

    Full Text Available Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA and 2-arachidonoylglycerol (2-AG, respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

  2. Endocannabinoids, related compounds and their metabolic routes.

    Science.gov (United States)

    Fezza, Filomena; Bari, Monica; Florio, Rita; Talamonti, Emanuela; Feole, Monica; Maccarrone, Mauro

    2014-10-24

    Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

  3. A growing codependency: compounding pharmacy and safety.

    Science.gov (United States)

    Prince, Bryan; Lundevall, Jeremy

    2013-01-01

    Pharmacists and pharmacy technicians are in constant contact with potent compounds. When compounding with powders, there is a susceptibility to environmental conditions such that proper containment be in place to keep the employees safe, the medicine free from cross contamination or the introduction of outside contaminants, and the workplace free from floating active pharmaceutical ingredient particles. Adapting powder hoods as safety devices that work in direct relation to clearly defined standard operating procedures and good lab practices will facilitate a safer lab environment for employees and ensure good-quality prescriptions. This article discusses the safety concerns of compounding with powders and the safety measures to consider when purchasing powder hoods.

  4. Pickpocket compounds from Latin to Romance

    DEFF Research Database (Denmark)

    Whitehead, Benedicte Nielsen

    This thesis discusses the development in Proto–Indo–European, Latin and Romance of a word–formation pattern which the most adequate terminology in use dubs ‘verbal government compounds with a governing first member’; I use the shorthand ‘pickpocket compounds’. The first member of such compounds......–noun, represented by truck–driver, has the deverbal member second and carries an agentive suffix, -er. Pickpocket compounds are attested in early strata of Greek and Indo–Iranian and in medieval strata of Germanic, Slavic and Romance. Latin has around a dozen examples. The scholarly debate, continued in this thesis...

  5. Synthesis of Novel Antifungal Triazole Compounds

    Institute of Scientific and Technical Information of China (English)

    Yong CHU; Ming Xia XU; Ding LU

    2004-01-01

    Based on our previous studies of 3D-QSAR, 38 novel objective compounds belonging to 4 series were designed and successfully synthesized directed by the idea of reconstructing the structure of non-pharmacophores while reserving essential ones in triazoles. In vitro pilot studies on their antifungal activities showed that most compounds have inhibitory effects on C.albicans and some inhibit S.cerevisiae also. The effects on C.albicans of 5 compounds are more potent than or equal to that of fluconazole or itraconazole.

  6. Food applications of natural antimicrobial compounds

    Directory of Open Access Journals (Sweden)

    Matteo Alessandro eDel Nobile

    2012-08-01

    Full Text Available In agreement with the current trend of giving value to natural and renewable resources, the use of natural antimicrobial compounds, particularly in food and biomedical applications, becomes very frequent. The direct addition of natural compounds to food is the most common method of application, even if numerous efforts have been made to find alternative solutions to the aim of avoiding undesirable inactivation. Dipping, spraying and coating treatment of food with active solutions are currently applied to product prior to packaging as valid options. The aim of the current work is to give an overview on the use of natural compounds in food sector. In particular, the review will gather numerous case-studies of meat, fish, dairy products, minimally processed fruit and vegetables and cereal-based products where these compounds found application.

  7. Trifluoromethylation of Carbonyl Compounds with Sodium Trifluoroacetate

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In the presence of copper (Ⅰ) halide as catalyst, a variety of carbonyl compounds could be trifluoromethylated with sodium trifluoroacetate to give the corresponding alcohols in moderate to high yields.

  8. New approach for screeninganti-tumor compounds

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    A new screening approach for anticancer active compounds is presented. In this method, a target enzyme is incubated with a mixture of compounds, and then the complex formed by the target and small molecules is separated from the rest of the mixture by ultra-filtration. The complex that is retained on the membrane is subsequently washed with acid and small molecules that are specifically bound to the target are released and collected, then analyzed by high-performance liquid chromatograph combined with electrospray ionization mass spectrometry (HPLC/ESI-MS) analysis. We have successfully applied this method to screen anti-cancer compounds. DNA topoisomeraseⅡ is used as a target to capture anti-tumor candidates from a mixture of combinatorial compounds, such as doxorubicin, daunorubicin and pravastain.

  9. Compound Option Pricing under Fuzzy Environment

    Directory of Open Access Journals (Sweden)

    Xiandong Wang

    2014-01-01

    Full Text Available Considering the uncertainty of a financial market includes two aspects: risk and vagueness; in this paper, fuzzy sets theory is applied to model the imprecise input parameters (interest rate and volatility. We present the fuzzy price of compound option by fuzzing the interest and volatility in Geske’s compound option pricing formula. For each α, the α-level set of fuzzy prices is obtained according to the fuzzy arithmetics and the definition of fuzzy-valued function. We apply a defuzzification method based on crisp possibilistic mean values of the fuzzy interest rate and fuzzy volatility to obtain the crisp possibilistic mean value of compound option price. Finally, we present a numerical analysis to illustrate the compound option pricing under fuzzy environment.

  10. Thermodynamic Analysis of Ionic Compounds: Synthetic Applications.

    Science.gov (United States)

    Yoder, Claude H.

    1986-01-01

    Shows how thermodynamic cycles can be used to understand trends in heats of formation and aqueous solubilities and, most importantly, how they may be used to choose synthetic routes to new ionic compounds. (JN)

  11. Phytoestrogens: Plant-derived Estrogenic Compounds

    Directory of Open Access Journals (Sweden)

    Nevzat Konar

    2011-12-01

    Full Text Available Estrogen is a hormone, which is produced in ovary and testis; however, it has many biological effects besides the reproductive system. Phytoestrogens are the compounds, which have estrogen-like structure and activities, taking place in structure of various edible plants at different levels and in different compositions. These compounds attracted notice after the first quarter of 20th century upon they had been associated with infertility seen in some of animals fed with alfalfa, and these compounds have been identified in human-derived biological samples and its effects on health have been taken under study in the recent 30 years. These materials have especially antioxidant role in plants while they have activities in animals and humans as estrogen agonist and antagonists. Based on their chemical structure, they may be gathered under especially isoflavon and lignan groups while some of members of coumestan and stilbene groups are also identified as phytoestrogenic compound.

  12. Organolead compounds shown to be genetically active

    Energy Technology Data Exchange (ETDEWEB)

    Ahlberg, J.; Ramel, C.; Wachtmeister, C.A.

    1972-01-01

    The purpose of the present investigation was to determine whether alkyllead compounds would cause a genetic effect similar to that caused by alkyl mercury compounds. Experiments were conducted on Allium cepa (onion) in order to determine the effect of lead compounds on the spindle fiber mechanism. Results indicate that disturbances of the spindle fiber mechanism occur even at very low concentrations. The lowest concentration at which such effects are observed seems to be between 10/sup -6/ and 10/sup -7/ M for the organic compounds. Although no effect can be observed on the spindle fibers at lower dosages, the mitotic index is changed even at a dose of 10/sup -7/ M with dimethyllead. A preliminary experiment was made on Drosophila with triethyllead in order to investigate whether the effects which were observed on mitoses in Allium would also be observed in a meiotic cell system in an animal.

  13. Negative thermal expansion in framework compounds

    Indian Academy of Sciences (India)

    R Mittal

    2008-10-01

    We have studied negative thermal expansion (NTE) compounds with chemi- cal compositions of NX2O8 and NX2O7 (N=Zr, Hf and X=W, Mo, V) and M2O (M=Cu, Ag) using the techniques of inelastic neutron scattering and lattice dynamics. There is a large variation in the negative thermal expansion coefficients of these compounds. The inelastic neutron scattering experiments have been carried out using polycrystalline and single crystal samples at ambient pressure as well as at high pressures. Experimental data are useful to confirm the predictions made from our lattice dynamical calculations as well as to check the quality of the interatomic potentials developed by us. We have been able to successfully model the NTE behaviour of these compounds. Our studies show that unusual phonon softening of low energy modes is able to account for NTE in these compounds.

  14. Mechanochemical reactions on copper-based compounds

    NARCIS (Netherlands)

    Castricum, H.L.; Bakker, H.; Poels, E.K.

    1999-01-01

    Mechanochemical reactions of copper and copper oxides with oxygen and carbon dioxide are discussed, as well as decomposition and reduction of copper compounds by mechanical milling under high-vacuum conditions.

  15. Atmospheric Chemistry of Micrometeoritic Organic Compounds

    Science.gov (United States)

    Kress, M. E.; Belle, C. L.; Pevyhouse, A. R.; Iraci, L. T.

    2011-01-01

    Micrometeorites approx.100 m in diameter deliver most of the Earth s annual accumulation of extraterrestrial material. These small particles are so strongly heated upon atmospheric entry that most of their volatile content is vaporized. Here we present preliminary results from two sets of experiments to investigate the fate of the organic fraction of micrometeorites. In the first set of experiments, 300 m particles of a CM carbonaceous chondrite were subject to flash pyrolysis, simulating atmospheric entry. In addition to CO and CO2, many organic compounds were released, including functionalized benzenes, hydrocarbons, and small polycyclic aromatic hydrocarbons. In the second set of experiments, we subjected two of these compounds to conditions that simulate the heterogeneous chemistry of Earth s upper atmosphere. We find evidence that meteor-derived compounds can follow reaction pathways leading to the formation of more complex organic compounds.

  16. The Industrial Reduction of Aromatic Nitro Compounds.

    Science.gov (United States)

    Gilbert, G.

    1980-01-01

    Describes methods for enriching an A-level chemistry course with a series of chemical company visits. The rationale is discussed for an emphasis of the visits on the industrial reduction of aromatic nitro compounds. (CS)

  17. DNA Modification with Photochromic Spiro Compounds

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The photochromic spiropyrans and spirooxazine having a succinimidyl ester or isothiocyanate pendant group can form covalent products with transaminated DNA.The absorption spectra and solid reflection spectra of modified DNA with these photochromic spiro compounds were investigated.

  18. Security evaluation of compounded microbial flocculant

    Institute of Scientific and Technical Information of China (English)

    马放; 王博; 范春; 杨基先; 李百祥; 刘艳滨

    2004-01-01

    A new kind of compounded microbial flocculant (CMBF) for water and wastewater treatment has been developed through biological technology. In order to discuss its biological security, four groups of experiments, rat acute toxicity test via mouth, salmonella assay in vitro, mouse micronucleus in vivo test and teratogenesis test were conducted to evaluate its general toxicity, genotoxicity and generative toxicity. The experimental results showed that this type of compounded microbial fiocculant was a substantial non-toxic substance based on the fact that LD50 value was over 10 mg/kg. The results from salmonella in vivo test and mouse micronucleus in vivo test revealed that the compounded microbial flocculant is a genetically non-toxic substance. Furthermore, compounded microbial flocculant has little effect on the growth of all the rats, and any morphologic abnormal phenomenon hasnt appeared.

  19. Electrode reactions and electroanalysis of organomercury compounds

    Energy Technology Data Exchange (ETDEWEB)

    Kurmaz, Vladimir A [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region (Russian Federation); Gul' tyai, Vadim P [N.D.Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation)

    2010-06-09

    Characteristic features of mechanisms and kinetics of electrode reactions of organomercury compounds (symmetrical, non-symmetrical) and organomercury salts on a mercury electrode are analyzed. Attention is focused on the effect of coordination, adsorption and the nature and properties of intermediates on these processes as well as on the formation of organomercury derivatives in the adsorption of organic and hetero-organic compounds on a mercury electrode. The kinetics of heterogeneous chemical equilibrium {sup o}rganic calomel{sup -}symmetrical organomercury compound in the adsorption layer and the relative stability of intermediates in the one-electron reduction of organomercury salts are discussed as well as the electrolytic hydrogen evolution catalyzed by organomercury intermediates. The problems of combined and separate electrochemical quantitation of organic and inorganic mercury compounds in natural objects are considered.

  20. Techniques for Analysis of Plant Phenolic Compounds

    Directory of Open Access Journals (Sweden)

    Thomas H. Roberts

    2013-02-01

    Full Text Available Phenolic compounds are well-known phytochemicals found in all plants. They consist of simple phenols, benzoic and cinnamic acid, coumarins, tannins, lignins, lignans and flavonoids. Substantial developments in research focused on the extraction, identification and quantification of phenolic compounds as medicinal and/or dietary molecules have occurred over the last 25 years. Organic solvent extraction is the main method used to extract phenolics. Chemical procedures are used to detect the presence of total phenolics, while spectrophotometric and chromatographic techniques are utilized to identify and quantify individual phenolic compounds. This review addresses the application of different methodologies utilized in the analysis of phenolic compounds in plant-based products, including recent technical developments in the quantification of phenolics.

  1. Expatriate Compound Living: An Ethnographic Field Study

    DEFF Research Database (Denmark)

    Lauring, Jakob; Selmer, Jan

    2009-01-01

    ethnographic field-work methodology, including interviews and participant observation during a period of three months, this exploratory study investigated 16 Danish business expatriates of a large Danish corporation and their families living in the same compound in Saudi Arabia. They shared their spare time...... and the expatriates had the same working hours in the same subsidiary. Results show that a Danish national group was established and maintained. This in-group dominated life in the compound and at work it may have contributed to the perceptual bias and discriminatory behaviour demonstrated by the Danish expatriates......In certain countries, closed expatriate compounds have developed.  They serve to provide resident expatriates and accompanying family members with a comfortable and safe environment. Unfortunately, not much is known about compound life since associated empirical research is scarce. Through...

  2. BASF Launches New Compounding Plant in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ BASF, a leading international chemical company,kicked off construction of an engineering plastics compounding plant Pudong Area in Shanghai in midMay. The new facility is a world-scale plant with annual capacity of 45,000 tons. It is one of the most modern compounding plants in the world today, with "the highest environmental standards and the most efficient production capabilities available," according to a BASF official.

  3. Techniques for Analysis of Plant Phenolic Compounds

    OpenAIRE

    Roberts, Thomas H.; Meredith A. Wilkes; Ali Khoddami

    2013-01-01

    Phenolic compounds are well-known phytochemicals found in all plants. They consist of simple phenols, benzoic and cinnamic acid, coumarins, tannins, lignins, lignans and flavonoids. Substantial developments in research focused on the extraction, identification and quantification of phenolic compounds as medicinal and/or dietary molecules have occurred over the last 25 years. Organic solvent extraction is the main method used to extract phenolics. Chemical procedures are used to detect the pre...

  4. Chalcones: compounds possessing a diversity in applications

    Directory of Open Access Journals (Sweden)

    Urmila Berar

    2012-10-01

    Full Text Available Chalcones are a class of α, β- unsaturated carbonyl compounds that form the central core for a variety of naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. Besides their various pharmacological activities, chalcones have been explored for different optical applications including second harmonic generation materials in non- linear optics, fluorescent probe for sensing different molecules.

  5. Health promoting compounds in vegetables and fruits:

    DEFF Research Database (Denmark)

    Brandt, K.; Christensen, L.P.; Hansen-Møller, J.

    2004-01-01

    Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxi...... in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats....

  6. Microwave Resonant Absorption of Potential Exothermic Compounds

    Science.gov (United States)

    1989-12-22

    exothermic materials: lead azide, lead styphnate , PETN, composition B, black powder, nitrocellulose, boron barium Chromate, and M-30 exhibit sharp...the exothermic materials. Table 1. Compounds Tested Compound Source 1 Lead Azide Broco Inc, Rialto CA 2 Lead Styphnate 3 PETN 4 Comp B 5 Black Powder 6...Nitrocellulose (12.6% Nitration) 7 Boron Barium Chromate ICI America, Valley Forge, PA 8 M30 (Gun Propellent) Radford Army Ammunition Plant, Radford

  7. Two new compounds from Zingiber officinale

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A new cyclic diarylheptanoid, 1,5-epoxy-3-hydroxy-1-(3-methoxy-4,5-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane (1), as well as a new monoterpene, 10-O-β-D-glucopyranosyl-hydroxy cineole (2) were isolated from the rhizomes of Zingiber officinale.The structures of compounds 1 and 2 were established based on their spectral data. In addition, the antioxidant activities of these compounds were also measured.

  8. Carbonyl compounds generated from electronic cigarettes.

    Science.gov (United States)

    Bekki, Kanae; Uchiyama, Shigehisa; Ohta, Kazushi; Inaba, Yohei; Nakagome, Hideki; Kunugita, Naoki

    2014-10-28

    Electronic cigarettes (e-cigarettes) are advertised as being safer than tobacco cigarettes products as the chemical compounds inhaled from e-cigarettes are believed to be fewer and less toxic than those from tobacco cigarettes. Therefore, continuous careful monitoring and risk management of e-cigarettes should be implemented, with the aim of protecting and promoting public health worldwide. Moreover, basic scientific data are required for the regulation of e-cigarette. To date, there have been reports of many hazardous chemical compounds generated from e-cigarettes, particularly carbonyl compounds such as formaldehyde, acetaldehyde, acrolein, and glyoxal, which are often found in e-cigarette aerosols. These carbonyl compounds are incidentally generated by the oxidation of e-liquid (liquid in e-cigarette; glycerol and glycols) when the liquid comes in contact with the heated nichrome wire. The compositions and concentrations of these compounds vary depending on the type of e-liquid and the battery voltage. In some cases, extremely high concentrations of these carbonyl compounds are generated, and may contribute to various health effects. Suppliers, risk management organizations, and users of e-cigarettes should be aware of this phenomenon.

  9. Carbonyl Compounds Generated from Electronic Cigarettes

    Directory of Open Access Journals (Sweden)

    Kanae Bekki

    2014-10-01

    Full Text Available Electronic cigarettes (e-cigarettes are advertised as being safer than tobacco cigarettes products as the chemical compounds inhaled from e-cigarettes are believed to be fewer and less toxic than those from tobacco cigarettes. Therefore, continuous careful monitoring and risk management of e-cigarettes should be implemented, with the aim of protecting and promoting public health worldwide. Moreover, basic scientific data are required for the regulation of e-cigarette. To date, there have been reports of many hazardous chemical compounds generated from e-cigarettes, particularly carbonyl compounds such as formaldehyde, acetaldehyde, acrolein, and glyoxal, which are often found in e-cigarette aerosols. These carbonyl compounds are incidentally generated by the oxidation of e-liquid (liquid in e-cigarette; glycerol and glycols when the liquid comes in contact with the heated nichrome wire. The compositions and concentrations of these compounds vary depending on the type of e-liquid and the battery voltage. In some cases, extremely high concentrations of these carbonyl compounds are generated, and may contribute to various health effects. Suppliers, risk management organizations, and users of e-cigarettes should be aware of this phenomenon.

  10. Synthesis of a new series of anti-rhinovirus compounds

    Institute of Scientific and Technical Information of China (English)

    Shi Yong Fan; Chun Lai Mi; Jun Yang; Song Li; Zhi Bing Zheng

    2007-01-01

    The synthesis of a series of 3,6-dichloropyridazine derivatives was described. In vitro experiment, all compounds exhibited an anti-rhinovirus activity, and one of the compounds 6g showed the comparable activity as our lead compound pirodavir.

  11. High Resolution Screening of biologically active compounds and metabolites

    NARCIS (Netherlands)

    Kool, J.

    2007-01-01

    High Resolution Screening of biologically active compounds and metabolites Jeroen Kool Biotransformation enzymes play a crucial role in the metabolism of both endogenous compounds and xenobiotics. Usually, the detoxication of these compounds by biotransformation enzymes results in harmless metab

  12. Chemical effect on diffusion in intermetallic compounds

    Science.gov (United States)

    Chen, Yi-Ting

    With the trend of big data and the Internet of things, we live in a world full of personal electronic devices and small electronic devices. In order to make the devices more powerful, advanced electronic packaging such as wafer level packaging or 3D IC packaging play an important role. Furthermore, ?-bumps, which connect silicon dies together with dimension less than 10 ?m, are crucial parts in advanced packaging. Owing to the dimension of ?-bumps, they transform into intermetallic compound from tin based solder after the liquid state bonding process. Moreover, many new reliability issues will occur in electronic packaging when the bonding materials change; in this case, we no longer have tin based solder joint, instead, we have intermetallic compound ?-bumps. Most of the potential reliability issues in intermetallic compounds are caused by the chemical reactions driven by atomic diffusion in the material; thus, to know the diffusivities of atoms inside a material is significant and can help us to further analyze the reliability issues. However, we are lacking these kinds of data in intermetallic compound because there are some problems if used traditional Darken's analysis. Therefore, we considered Wagner diffusivity in our system to solve the problems and applied the concept of chemical effect on diffusion by taking the advantage that large amount of energy will release when compounds formed. Moreover, by inventing the holes markers made by Focus ion beam (FIB), we can conduct the diffusion experiment and obtain the tracer diffusivities of atoms inside the intermetallic compound. We applied the technique on Ni3Sn4 and Cu3Sn, which are two of the most common materials in electronic packaging, and the tracer diffusivities are measured under several different temperatures; moreover, microstructure of the intermetallic compounds are investigated to ensure the diffusion environment. Additionally, the detail diffusion mechanism was also discussed in aspect of diffusion

  13. Nature of phenolic compounds in coffee melanoidins.

    Science.gov (United States)

    Coelho, Carina; Ribeiro, Miguel; Cruz, Ana C S; Domingues, M Rosário M; Coimbra, Manuel A; Bunzel, Mirko; Nunes, Fernando M

    2014-08-06

    Phenolic compounds are incorporated into coffee melanoidins during roasting mainly in condensed form (42-62 mmol/100 g) and also in ester-linked form (1.1-1.6 mmol/100 g), with incorporation levels depending on the green coffee chlorogenic acid content. The phenolic compounds are incorporated in different coffee melanoidin populations, but mainly in those soluble in 75% ethanol (82%), a significant correlation between the amount of phenolic compounds and the amount of protein and color characteristics of the different melanoidin populations being observed. The incorporation of phenolic compounds into coffee melanoidins is a significant pathway of chlorogenic acid degradation during roasting, representing 23% of the chlorogenic acids lost. These account for the nearly 26% of the material not accounted for by polysaccharides and proteins present in coffee melanodins. The cleavage mechanism and the efficiency of alkaline fusion used to release condensed phenolics from coffee melanoidins suggest that the phenolic compounds can be linked to the polymeric material by aryl-ether, stilbene type, and/or biphenyl linkages.

  14. Macrocyclic trichothecenes as antifungal and anticancer compounds.

    Science.gov (United States)

    de Carvalho, Maira Peres; Weich, Herbert; Abraham, Wolf-Rainer

    2016-01-01

    Trichothecenes are sesquiterpenoid metabolites produced by fungi and species of the plant genus Baccharis, family Asteraceae. They comprise a tricyclic core with an epoxide at C-12 and C-13 and can be grouped into non-macrocyclic and macrocyclic compounds. While many of these compounds are of concern in agriculture, the macrocyclic metabolites have been evaluated as antiviral, anti-cancer, antimalarial and antifungal compounds. Some known cytotoxic responses on eukaryotic cells include inhibition of protein, DNA and RNA syntheses, interference with mitochondrial function, effects on cell division and membranes. These targets however have been elucidated essentially employing non-macrocyclic trichothecenes and only one or two closely related macrocyclic compounds. For several macrocyclic trichothecenes high selectivity against fungal species and against cancer cell lines have been reported suggesting that the macrocycle and its stereochemistry are of crucial importance regarding biological activity and selectivity. This review is focused on compounds belonging to the macrocyclic type, where a cyclic diester or triester ring binds to the trichothecane moiety at C-4 and C- 15 leading to natural products belonging to the groups of satratoxins, verrucarins, roridins, myrotoxins and baccharinoids. Their biological activities, cytotoxic mechanisms and structure-activity relationships (SAR) are discussed. From the reported data it becomes evident that even small changes in the molecules can lead to pronounced effects on biological activity or selectivity against cancer cells lines. Understanding the underlying mechanisms may help to design highly specific drugs for cancer therapy.

  15. Cerium-iron-based magnetic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Chen; Pinkerton, Frederick E.; Herbst, Jan F.

    2017-01-17

    New magnetic materials containing cerium, iron, and small additions of a third element are disclosed. These materials comprise compounds Ce(Fe.sub.12-xM.sub.x) where x=1-4, having the ThMn.sub.12 tetragonal crystal structure (space group I4/mmm, #139). Compounds with M=B, Al, Si, P, S, Sc, Co, Ni, Zn, Ga, Ge, Zr, Nb, Hf, Ta, and W are identified theoretically, and one class of compounds based on M=Si has been synthesized. The Si cognates are characterized by large magnetic moments (4.pi.M.sub.s greater than 1.27 Tesla) and high Curie temperatures (264.ltoreq.T.sub.c.ltoreq.305.degree. C.). The Ce(Fe.sub.12-xM.sub.x) compound may contain one or more of Ti, V, Cr, and Mo in combination with an M element. Further enhancement in T.sub.c is obtained by nitriding the Ce compounds through heat treatment in N.sub.2 gas while retaining the ThMn.sub.12 tetragonal crystal structure; for example CeFe.sub.10Si.sub.2N.sub.1.29 has T.sub.c=426.degree. C.

  16. Reflectance spectroscopy of organic compounds: 1. Alkanes

    Science.gov (United States)

    Clark, R.N.; Curchin, J.M.; Hoefen, T.M.; Swayze, G.A.

    2009-01-01

    Reflectance spectra of the organic compounds comprising the alkane series are presented from the ultraviolet to midinfrared, 0.35 to 15.5 /??m. Alkanes are hydrocarbon molecules containing only single carbon-carbon bonds, and are found naturally on the Earth and in the atmospheres of the giant planets and Saturn's moon, Titan. This paper presents the spectral properties of the alkanes as the first in a series of papers to build a spectral database of organic compounds for use in remote sensing studies. Applications range from mapping the environment on the Earth, to the search for organic molecules and life in the solar system and throughout the. universe. We show that the spectral reflectance properties of organic compounds are rich, with major diagnostic spectral features throughout the spectral range studied. Little to no spectral change was observed as a function of temperature and only small shifts and changes in the width of absorption bands were observed between liquids and solids, making remote detection of spectral properties throughout the solar system simpler. Some high molecular weight organic compounds contain single-bonded carbon chains and have spectra similar to alkanes even ' when they fall into other families. Small spectral differences are often present allowing discrimination among some compounds, further illustrating the need to catalog spectral properties for accurate remote sensing identification with spectroscopy.

  17. Excretion of biliary compounds during intrauterine life

    Science.gov (United States)

    Macias, Rocio IR; Marin, Jose JG; Serrano, Maria A

    2009-01-01

    In adults, the hepatobiliary system, together with the kidney, constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine, respectively. However, during intrauterine life the biliary route of excretion for cholephilic compounds, such as bile acids and biliary pigments, is very poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. PMID:19230042

  18. Phenolic compounds in Rosaceae fruits from Ecuador.

    Science.gov (United States)

    Vasco, Catalina; Riihinen, Kaisu; Ruales, Jenny; Kamal-Eldin, Afaf

    2009-02-25

    RP-HPLC-DAD was used to study the content of phenolic compounds in four Ecuadorian fruits (strawberry, Andean blackberry, plum, and capuli cherry). Compounds were identified using spectral characteristics of representative standards and reference samples. Further, LC-MS with MS/MS was used to confirm molecular assignments in previously unstudied capuli cherry. Gallic acid was detected in Andean blackberry, and galloyl esters were detected in strawberries. Both these berries contained ellagic acid derivatives as major compounds, followed by anthocyanins, cyanidin, and pelargonidin glycosides. Plums and capuli cherry showed similar profiles of phenolic compounds, with chlorogenic and neochlorogenic acids being the most important hydroxycinnamates. (-)-Epicatechin was found in high amounts in Andean blackberry, plums, and capuli cherry, while (+)-catechin was only found in capuli cherry. Proanthocyanidins were major compounds in all fruits, and all contained considerable amounts of quercetin derivatives and smaller amounts of kaempferol derivatives. LC-MS analysis of capuli cherry revealed dimeric and trimeric procyanidins, quercetin and kaempferol hexosides and pentosides, and a kaempferol-O,C-dipentoside.

  19. Basics and prospective of magnetic Heusler compounds

    Directory of Open Access Journals (Sweden)

    Claudia Felser

    2015-04-01

    Full Text Available Heusler compounds are a remarkable class of materials with more than 1000 members and a wide range of extraordinary multi-functionalities including halfmetallic high-temperature ferri- and ferromagnets, multi-ferroics, shape memory alloys, and tunable topological insulators with a high potential for spintronics, energy technologies, and magneto-caloric applications. The tunability of this class of materials is exceptional and nearly every functionality can be designed. Co2-Heusler compounds show high spin polarization in tunnel junction devices and spin-resolved photoemission. Manganese-rich Heusler compounds attract much interest in the context of spin transfer torque, spin Hall effect, and rare earth free hard magnets. Most Mn2-Heusler compounds crystallize in the inverse structure and are characterized by antiparallel coupling of magnetic moments on Mn atoms; the ferrimagnetic order and the lack of inversion symmetry lead to the emergence of new properties that are absent in ferromagnetic centrosymmetric Heusler structures, such as non-collinear magnetism, topological Hall effect, and skyrmions. Tetragonal Heusler compounds with large magneto crystalline anisotropy can be easily designed by positioning the Fermi energy at the van Hove singularity in one of the spin channels. Here, we give a comprehensive overview and a prospective on the magnetic properties of Heusler materials.

  20. Polymers containing borane or carborane cage compounds and related applications

    Science.gov (United States)

    Bowen, III, Daniel E; Eastwood, Eric A

    2013-04-23

    Polymers comprising residues of cage compound monomers having at least one polyalkoxy silyl substituent are provided. The cage compound monomers are selected from borane cage compound monomers comprising at least 7 cage atoms and/or carborane cage compound monomers comprising 7 to 11 cage compound monomers. Such polymers can further comprise one or more reactive matrices and/or co-monomers covalently bound with the cage compound monomer residues. Articles of manufacture comprising such polymers are also disclosed.

  1. Radiation synthesis of materials and compounds

    CERN Document Server

    Kharisov, Boris Ildusovich; Ortiz Méndez, Ubaldo

    2013-01-01

    Researchers and engineers working in nuclear laboratories, nuclear electric plants, and elsewhere in the radiochemical industries need a comprehensive handbook describing all possible radiation-chemistry interactions between irradiation and materials, the preparation of materials under distinct radiation types, the possibility of damage of materials under irradiation, and more. Radiation nanotechnology is still practically an undeveloped field, except for some achievements in the fabrication of metallic nanoparticles under ionizing flows. Radiation Synthesis of Materials and Compounds presents the state of the art of the synthesis of materials, composites, and chemical compounds, and describes methods based on the use of ionizing radiation. It is devoted to the preparation of various types of materials (including nanomaterials) and chemical compounds using ionizing radiation (alpha particles, beta particles, gamma rays, x-rays, and neutron, proton, and ion beams). The book presents contributions from leaders ...

  2. Magnetic phase transitions in layered intermetallic compounds

    Science.gov (United States)

    Mushnikov, N. V.; Gerasimov, E. G.; Rosenfeld, E. V.; Terent'ev, P. B.; Gaviko, V. S.

    2012-10-01

    Magnetic, magnetoelastic, and magnetotransport properties have been studied for the RMn2Si2 and RMn6Sn6 (R is a rare earth metal) intermetallic compounds with natural layered structure. The compounds exhibit wide variety of magnetic structures and magnetic phase transitions. Substitution of different R atoms allows us to modify the interatomic distances and interlayer exchange interactions thus providing the transition from antiferromagnetic to ferromagnetic state. Near the boundary of this transition the magnetic structures are very sensitive to the external field, temperature and pressure. The field-induced transitions are accompanied by considerable change in the sample size and resistivity. It has been shown that various magnetic structures and magnetic phase transitions observed in the layered compounds arise as a result of competition of the Mn-Mn and Mn-R exchange interactions.

  3. Feasibility of a complex compound heat pump

    Science.gov (United States)

    Rockenfeller, Uwe

    1987-07-01

    A feasibility study is described of a double effect gas fired heat pump using ammoniated solid vapor complex compounds as the working media. The cycle takes advantage of the coordinative characteristics of complex compound ligand bonds resulting in large coordination spheres with only one degree of freedom. The cycle has high efficiency, no moving parts, and minimum electrical parasitic requirements. Fluid properties of candidate materials were measured with respect to vapor pressure equilibria, coordination properties and thermal stability. Preliminary reaction rate measurements were performed in adsorption and desorption processes. A computer model of double effect cycle was developed in order to predict the operating performance of the candidate complex compound media. The computer model was used to determine preliminary heat balances and coefficients of performance.

  4. [Platinum compounds: metabolism, toxicity and supportive strategies].

    Science.gov (United States)

    Lipp, H P; Hartmann, J T

    2005-02-09

    Although the leading platinum compounds, cisplatin, carboplatin, and oxaliplatin, share some structural similarities, there are marked differences between them in therapeutic uses, pharmacokinetics, and adverse effects profiles. Compared with cisplatin, carboplatin has inferior efficacy in germ-cell tumors, head and neck cancers, and bladder and esophageal carcinomas, whereas the two drugs appear to have comparable efficacy in ovarian cancer, extensive small-cell lung cancers (SCLC), and advanced non-small-cell lung cancers (NSCLC). Oxaliplatin belongs to the group of diaminocyclohexane (DACH) platinum compounds. It is the first platinum-based drug that has marked efficacy in colorectal cancer when given in combination with 5-fluorouracil and folinic acid. Nedaplatin has been registered in Japan, whereas other derivatives, like JM216 (which is the only orally available platinum derivative), ZD0473, BBR3464, and SPI-77 (a liposomal formulation of cisplatin), are still under investigation. The adverse effects of platinum compounds are reviewed together with possible prevention strategies.

  5. Bioactive Compounds Found in Brazilian Cerrado Fruits

    Directory of Open Access Journals (Sweden)

    Elisa Flávia Luiz Cardoso Bailão

    2015-10-01

    Full Text Available Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi, Dipteryx alata Vog. (baru, Eugenia dysenterica DC. (cagaita, Eugenia uniflora L. (pitanga, Genipa americana L. (jenipapo, Hancornia speciosa Gomes (mangaba, Mauritia flexuosa L.f. (buriti, Myrciaria cauliflora (DC Berg (jabuticaba, Psidium guajava L. (goiaba, Psidium spp. (araçá, Solanum lycocarpum St. Hill (lobeira, Spondias mombin L. (cajá, Annona crassiflora Mart. (araticum, among others are reported here.

  6. Compound control methodology for flight vehicles

    CERN Document Server

    Xia, Yuanqing

    2013-01-01

    Compound Control Methodology for Flight Vehicles” focuses on new control methods for flight vehicles. In this monograph the concept of compound control is introduced. It is demonstrated that both Sliding Mode Control (SMC) and Active Disturbance Rejection Control (ADRC) have their own advantages and limitations, i.e., chattering of SMC and the observability of extended state observer (ESO), respectively. It is shown that compound control combines their advantages and improves the performance of the closed-loop systems. The book is self-contained, providing sufficient mathematical foundations for understanding the contents of each chapter. It will be of significant interest to scientists and engineers engaged in the field of flight vehicle control.

  7. Bioactive Compounds Found in Brazilian Cerrado Fruits.

    Science.gov (United States)

    Bailão, Elisa Flávia Luiz Cardoso; Devilla, Ivano Alessandro; da Conceição, Edemilson Cardoso; Borges, Leonardo Luiz

    2015-10-09

    Functional foods include any natural product that presents health-promoting effects, thereby reducing the risk of chronic diseases. Cerrado fruits are considered a source of bioactive substances, mainly phenolic compounds, making them important functional foods. Despite this, the losses of natural vegetation in the Cerrado are progressive. Hence, the knowledge propagation about the importance of the species found in Cerrado could contribute to the preservation of this biome. This review provides information about Cerrado fruits and highlights the structures and pharmacologic potential of functional compounds found in these fruits. Compounds detected in Caryocar brasiliense Camb. (pequi), Dipteryx alata Vog. (baru), Eugenia dysenterica DC. (cagaita), Eugenia uniflora L. (pitanga), Genipa americana L. (jenipapo), Hancornia speciosa Gomes (mangaba), Mauritia flexuosa L.f. (buriti), Myrciaria cauliflora (DC) Berg (jabuticaba), Psidium guajava L. (goiaba), Psidium spp. (araçá), Solanum lycocarpum St. Hill (lobeira), Spondias mombin L. (cajá), Annona crassiflora Mart. (araticum), among others are reported here.

  8. Reliability and radiation effects in compound semiconductors

    CERN Document Server

    Johnston, Allan

    2010-01-01

    This book discusses reliability and radiation effects in compound semiconductors, which have evolved rapidly during the last 15 years. Johnston's perspective in the book focuses on high-reliability applications in space, but his discussion of reliability is applicable to high reliability terrestrial applications as well. The book is important because there are new reliability mechanisms present in compound semiconductors that have produced a great deal of confusion. They are complex, and appear to be major stumbling blocks in the application of these types of devices. Many of the reliability problems that were prominent research topics five to ten years ago have been solved, and the reliability of many of these devices has been improved to the level where they can be used for ten years or more with low failure rates. There is also considerable confusion about the way that space radiation affects compound semiconductors. Some optoelectronic devices are so sensitive to damage in space that they are very difficu...

  9. Magnetic anisotropies of rare-earth compounds

    Science.gov (United States)

    Loewenhaupt, M.; Rotter, M.; Kramp, S.

    2000-03-01

    There are two kinds of magnetic anisotropy in rare-earth compounds: the single-ion anisotropy caused by the crystal field (CF) and the anisotropy of the two-ion interactions. Both types of anisotropy have to be considered to arrive at a consistent description of the magnetic properties of the orthorhombic intermetallic compound NdCu 2. From the analysis of NdCu 2 we can derive predictions for the type of ordering in other isostructural RCu 2 compounds, that agree well with experimental results: If the magnetic moments point into the crystallographic b-direction, an ordering wave vector of (2/3 0 0) is expected. If the moments are oriented perpendicular to b then the ordering wave vector is (2/3 1 0) .

  10. Antiviral lead compounds from marine sponges

    KAUST Repository

    Sagar, Sunil

    2010-10-11

    Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hopedto be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed. 2010 by the authors; licensee MDPI.

  11. Antiviral effect of cationic compounds on bacteriophages

    Directory of Open Access Journals (Sweden)

    Mai Huong eChatain-Ly

    2013-03-01

    Full Text Available The antiviral activity of several cationic compounds - cetytrimethylammonium (CTAB, chitosan, nisin and lysozyme - was investigated on the bacteriophage c2 (DNA head and non-contractile tail infecting Lactococcus strains and the bacteriophage MS2 (F-specific RNA infecting E.coli. Firstly, these activities were evaluated in a phosphate buffer pH 7- 10 mM. The CTAB had a virucidal effect on the Lactococcus bacteriophages, but not on the MS2. After 1 min of contact with 0.125 mM CTAB, the c2 population was reduced from 6 log(pfu/mL to 1,5 log(pfu/mL and completely deactivated at 1 mM. On the contrary, chitosan inhibited the MS2 more than it did the bacteriophages c2. No antiviral effect was observed for the nisin or the lysozyme on bacteriophages after 1 min of treatment. A 1 and 2.5 log reduction was respectively observed for nisin and lysozyme when the treatment time increased (5 or 10 min. These results showed that the antiviral effect depended both on the virus and structure of the antimicrobial compounds. The antiviral activity of these compounds was also evaluated in different physico-chemical conditions and in complex matrices. The antiviral activity of CTAB was impaired in acid pH and with an increase of the ionic strength. These results might be explained by the electrostatic interactions between cationic compounds and negatively charged particles such as bacteriophages or other compounds in a matrix. Milk proved to be protective suggesting the components of food could interfere with antimicrobial compounds.

  12. Synthesis of Dibenzylidene Sorbitol Series Compound

    Institute of Scientific and Technical Information of China (English)

    FENG Rongxiu; CHEN Ligong; HOU Zhongke; SONG Jian

    2007-01-01

    A series of alditol derivatives were designed and synthesized with relatively high yield. On the basis of reaction between sorbitol and a series of substituted benzaldehyde in the presence of an acid catalyst, a series of acetal derivatives were synthesized through free hydroxyl esterification. D-sorbitol acetal amido derivatives were prepared by reduction of nitryl and acylation of amino. Dsorbitol acetal carboxyl esterification derivatives were prepared through esterification and hydrolysis. By high performance liquid chromatography-mass spectra (HPLC-MS) and H nuclear magneticresonance spectra (1 H-NMR), 36 compounds prepared were identified. Among these derivatives prepared, 26 compounds have not been reported in the previous literatures.

  13. Bioactive compounds from Iostephane heterophylla (Asteraceae).

    Science.gov (United States)

    Aguilar, M I; Delgado, G; Hernández, M L; Villarreal, M L

    2001-01-01

    The novel bisabolene sesquiterpenes 3-6, were isolated from Iostephane heterophylla, using bioguided fractionation. The new compounds were determined to be (12R/12S)-12,13-epoxy-xanthorrhizols (3,4) and (12R/12S)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). The stereochemistry at C-12 of 5 was deduced using the modified Mosher experiment. Some of the isolated compounds elicited activity against gram positive and gram negative bacteria, levadura and dermatophytes.

  14. Volatile compound formation during argan kernel roasting.

    Science.gov (United States)

    El Monfalouti, Hanae; Charrouf, Zoubida; Giordano, Manuela; Guillaume, Dominique; Kartah, Badreddine; Harhar, Hicham; Gharby, Saïd; Denhez, Clément; Zeppa, Giuseppe

    2013-01-01

    Virgin edible argan oil is prepared by cold-pressing argan kernels previously roasted at 110 degrees C for up to 25 minutes. The concentration of 40 volatile compounds in virgin edible argan oil was determined as a function of argan kernel roasting time. Most of the volatile compounds begin to be formed after 15 to 25 minutes of roasting. This suggests that a strictly controlled roasting time should allow the modulation of argan oil taste and thus satisfy different types of consumers. This could be of major importance considering the present booming use of edible argan oil.

  15. Web-accessible Chemical Compound Information

    OpenAIRE

    Roth, Dana L

    2008-01-01

    Web-accessible chemical compound information resources are widely available. In addition to fee-based resources, such as SciFinder Scholar and Beilstein, there is a wide variety of freely accessible resources such as ChemSpider and PubChem. The author provides a general description of various fee-based and free chemical compound resources. The free resources generally offer an acceptable alternative to fee-based resources for quick retrieval. It is assumed that readers will be familiar with ...

  16. Dissolution behavior of lithium compounds in ethanol

    Directory of Open Access Journals (Sweden)

    Tomohiro Furukawa

    2016-12-01

    Full Text Available In order to exchange the components which received irradiation damage during the operation at the International Fusion Materials Irradiation Facility, the adhered lithium, which is partially converted to lithium compounds such as lithium oxide and lithium hydroxide, should be removed from the components. In this study, the dissolution experiments of lithium compounds (lithium nitride, lithium hydroxide, and lithium oxide were performed in a candidate solvent, allowing the clarification of time and temperature dependence. Based on the results, a cleaning procedure for adhered lithium on the inner surface of the components was proposed.

  17. Validation of EXAFS Analysis of Iridium Compounds

    Science.gov (United States)

    Feiters, M. C.; Longo, A.; Banerjee, D.; van der Ham, C. J. M.; Hetterscheid, D. G. H.

    2016-05-01

    Results of iridium L3 edge EXAFS measurements of compounds relevant for water oxidation catalysis are compared to those of other structural techniques. The structural results from EXAFS for the Ir compounds investigated here compare well to those of other structural techniques. Multiple scattering contributions are important in the coordinated Cp* and NHC ligands as well as in the IrCl6 unit and the IrO2 rutile structure. NHC is relatively weak compared to Ir, Cl, and even Cp* and O, and often out of phase with the other contributions.

  18. Exchange bias effect in alloys and compounds.

    Science.gov (United States)

    Giri, S; Patra, M; Majumdar, S

    2011-02-23

    The phenomenology of exchange bias effects observed in structurally single-phase alloys and compounds but composed of a variety of coexisting magnetic phases such as ferromagnetic, antiferromagnetic, ferrimagnetic, spin-glass, cluster-glass and disordered magnetic states are reviewed. The investigations on exchange bias effects are discussed in diverse types of alloys and compounds where qualitative and quantitative aspects of magnetism are focused based on macroscopic experimental tools such as magnetization and magnetoresistance measurements. Here, we focus on improvement of fundamental issues of the exchange bias effects rather than on their technological importance.

  19. Magnetic moment densities in selected UTX compounds

    Energy Technology Data Exchange (ETDEWEB)

    Javorsky, P.; Schweizer, J.; Givord, F.; Boucherle, J.-X.; Andreev, A.V.; Divis, M.; Lelievre-Berna, E.; Sechovsky, V

    2004-07-15

    We present results of polarized neutron-diffraction studies of magnetization distribution in several isostructural UTX compounds. Besides the uranium magnetic moment, we observe a significant magnetization also on the transition-metal sites and in the interstitial region, close to the X-atom site. The values of the moments induced on the T-atoms in the U-T and T-X basal planes are rather similar for compounds with 3d-metals, UNiGa, UNiAl, and UCoAl, while a difference occurs in UPtAl. Our results are compared with literature data for URhAl and URuAl.

  20. NUMERICAL MODELING OF COMPOUND CHANNEL FLOWS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A numerical model capable of predicting flow characteristics in a compound channel was established with the 3-D steady continuity and momentum equations along with the transport equations for turbulence kinetic energy and dissipation rate. Closure was achieved with the aid of algebraic relations for turbulent shear stresses. The above equations were discretized with implicit difference approach and solved with a step method along the flow direction. The computational results showing the lateral distribution of vertical average velocities and the latio of total flow in the compound channel agree well with the available experimental data.

  1. Basics of sterile compounding: bubble point testing.

    Science.gov (United States)

    Thoma, Laura

    2014-01-01

    Compounding pharmacies that compound sterile preparations must choose sterile filters that are approved for human use. They may rely on the filter manufacturer's Certificate of Quality to ensure the sterile filter is pyrogen free and has been tested for bacterial retention. The Certificate of Quality from the filter manufacturer also contains other useful information about the filter such as: flow rate and maximum pressure drop, thermal and hydraulic stress, and membrane results of the initial integrity test performed on the filter membrane with water, if a hydrophilic membrane. This article discusses the integrity test, which is often called the water bubble point test.

  2. Broad spectrum antibiotic compounds and use thereof

    Energy Technology Data Exchange (ETDEWEB)

    Koglin, Alexander; Strieker, Matthias

    2016-07-05

    The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described.

  3. Compound and quasi-compound states in low-energy scattering of nucleons from 12C

    CERN Document Server

    Pisent, G; Canton, L; Amos, K; Karataglidis, S; Van der Knijff, D

    2005-01-01

    A multi-channel algebraic scattering theory has been used to study the properties of nucleon scattering from 12C and of the sub-threshold compound nuclear states, accounting for properties in the compound nuclei to ~10 MeV. All compound and quasi-compound resonances observed in total cross-section data are matched, and on seeking solutions of the method at negative energies, all sub-threshold states in 13C and 13N are predicted with the correct spin-parities and with reasonable values for their energies. A collective-model prescription has been used to define the initiating nucleon-12C interactions and via use of orthogonalizing pseudo-potentials, account is made of the Pauli principle. Information is extracted on the underlying structure of each state in the compound systems by investigating the zero-deformation limit of the results.

  4. A Novel Route of Furan Compounds Syntheses

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A series of compounds that contained furan skeletons were synthesized using 3,4-bis(trimethylsilyl)furan as staring material. 1H NMR, 13C NMR, MS and EA had identified these new molecules. The important factors that influenced reactions were discussed, and the new furan intermediates could be used in various organic syntheses.

  5. Quantum chemical studies of estrogenic compounds

    Science.gov (United States)

    Quantum chemical methods are potent tools to provide information on the chemical structure and electronic properties of organic molecules. Modern computational chemistry methods have provided a great deal of insight into the binding of estrogenic compounds to estrogenic receptors (ER), an important ...

  6. Iron(III) spin crossover compounds

    NARCIS (Netherlands)

    van Koningsbruggen, PJ; Maeda, Y; Oshio, H

    2004-01-01

    In this chapter, selected results obtained so far on Fe(III) spin crossover compounds are summarized and discussed. Fe(III) spin transition materials of ligands containing chalcogen donor atoms are considered with emphasis on those of N,N-disubstituted-dithiocarbamates, N,N-disubstituted-XY-carbamat

  7. Analyzing volatile compounds in dairy products

    Science.gov (United States)

    Volatile compounds give the first indication of the flavor in a dairy product. Volatiles are isolated from the sample matrix and then analyzed by chromatography, sensory methods, or an electronic nose. Isolation may be performed by solvent extraction or headspace analysis, and gas chromatography i...

  8. Adsorption of Organic Compounds to Building Products

    DEFF Research Database (Denmark)

    Kjær, Ulla Dorte

    The presence of VOCs (Volatile Organic Compounds) in the indoor air may be a contributory cause of complaints about irritation of mucous membranes in eyes, nose and throat, difficulty in breathing, frequent airway inflammation, skin irritation, fatigue, concentration difficulty, dizziness and hea...

  9. Xeno-estrogenic compounds in precipitation

    NARCIS (Netherlands)

    Peters, R.J.B.; Beeltje, H.; Delft, R.J.

    2008-01-01

    The exposure to some chemicals can lead to hormone disrupting effects. Presently, much attention is focused on so-called xeno-estrogens, synthetic compounds that interact with hormone receptors causing a number of reactions that eventually lead to effects related to reproduction and development. The

  10. Study on resistance coefficient in compound channels

    Institute of Scientific and Technical Information of China (English)

    Kejun Yang; Shuyou Cao; Xingnian Liu; Ron Marshall

    2005-01-01

    This paper presents a further study of the Manning and Darcy-Weisbach resistance coefficients, as they play a significant role in assessing the cross-sectional mean velocity, conveyance capacity and determining the lateral distribution of depth mean velocity and local boundary shear stress in compound channels. The relationships between the local, zonal and overall resistance coefficients, and a wide range of geometries and different roughness between the main channel and the flood plain are established by analyzing a vast amount of experimental data from a British Science and Engineering Research Council Flood Channel Facility (SERC-FCF). And the experimental results also show that the overall Darcy-Weisbach resistance coefficient for a compound channel is the function of Reynolds number, but the function relationship is different from that for a single channel. By comparing and analyzing the conventional methods with the experimental data to predict composite roughness in compound channels, it is found that these methods are not suitable for compound channels. Moreover, the reason why the conventional methods cannot assess correctly the conveyance capacity of com pound channels is also analyzed in this paper.

  11. The Compoundness and Sequentiality of Digital Inequality

    NARCIS (Netherlands)

    Deursen, van Alexander; Helsper, Ellen; Eynon, Rebecca; Dijk, van Jan

    2017-01-01

    Through a survey with a representative sample of Dutch Internet users, this article examines compound digital exclusion: whether a person who lacks a particular digital skill also lacks another kind of skill, whether a person who does not engage in a particular way online is also less likely to enga

  12. Two new phenolic compounds from Artemisia sphaerocephala

    Institute of Scientific and Technical Information of China (English)

    Dong Bao Zhao; Lin Xi Li; Xiu Hua Liu; Ming Jing Li; Wen Ling Wang

    2007-01-01

    Two new phenolic compounds were isolated from whole plant of Artemisia sphaerocephala. The structures were elucidated on the basis of spectroscopic methods as 4-(1-hydroxylethyl)-phenol-1-O-β-D-glucopyranoside and 4-O-acetophenone-β-D-glucopyranosyl-(1-3)-β-D-glucopyranoside.

  13. Baseline isotopic data of polyhalogenated compounds

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Walter [University of Hohenheim, Institute of Food Chemistry, Garbenstr. 28, D-70593 Stuttgart (Germany)]. E-mail: w-vetter@uni-hohenheim.de; Armbruster, Wolfgang [University of Hohenheim, Institute of Food Chemistry, Garbenstr. 28, D-70593 Stuttgart (Germany); Betson, Tatiana R. [Medical Biochemistry and Biophysics, Umea University, SE-901 87 Umea (Sweden); Schleucher, Juergen [Medical Biochemistry and Biophysics, Umea University, SE-901 87 Umea (Sweden); Kapp, Thomas [University of Hohenheim, Institute of Food Chemistry, Garbenstr. 28, D-70593 Stuttgart (Germany); Lehnert, Katja [University of Hohenheim, Institute of Food Chemistry, Garbenstr. 28, D-70593 Stuttgart (Germany)

    2006-09-08

    The {delta} {sup 2}H- and {delta} {sup 13}C-values of polyhalogenated compounds were determined by EA-IRMS. Most of the compounds were related to the chloropesticides DDT and its metabolites, hexachlorocyclohexanes, and toxaphene, as well as several polybrominated compounds such as bromophenols and -anisoles. {delta} {sup 2}H-values ranged between -235 per mille and +75 per mille whereas {delta} {sup 13}C-values were found in the range -22 per mille to -38 per mille . No correlation between {delta} {sup 2}H- and {delta} {sup 13}C-values could be identified. Comparative analysis clarified that bromophenols and the corresponding bromoanisoles may vary in their isotopic distribution. {sup 2}H NMR was used to quantify abundances of {sup 2}H isotopomers. Quantification of isotopomers of 2,4-dibromophenol and 2,4-dibromoanisole proved that both compounds from different suppliers do not originate from the same source. Differences in the {delta} {sup 2}H-values of two toxaphene products were further investigated by the synthesis of products of different degree of chlorination from camphene. It was shown that the {delta} {sup 13}C-values remained mostly unaltered as was expected since no carbon is lost in this procedure. However, the reaction products became enriched in {sup 2}H with increasing degree of chlorination. Different {delta} {sup 2}H-values of the starting material will also impact the {delta} {sup 2}H-values of the chlorination products.

  14. Photoelectron spectroscopy of strongly correlated Yb compounds

    Energy Technology Data Exchange (ETDEWEB)

    Joyce, J.J.; Andrews, A.B.; Arko, A.J.; Bartlett, R.J.; Blythe, R.I. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Olson, C.G.; Benning, P.J.; Canfield, P.C. [Ames Laboratory, U. S. Department of Energy, Ames, Iowa 50011 (United States); Poirier, D.M. [Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455 (United States)

    1996-12-01

    The electronic properties of the Yb compounds YBCu{sub 2}Si{sub 2}, YBAgCu{sub 4}, and YbAl{sub 3} along with purely divalent Yb metal, have been investigated by means of high-resolution ultraviolet and x-ray photoelectron spectroscopy. We present the intrinsic characteristic features of the 4{ital f} levels of Yb while accounting for lattice vibrations and the manifestation of corelike energy levels degenerate with the valence states and modified by the temperature-dependent Fermi function. For these strongly correlated Yb-based compounds, the hole occupancy values ({ital n}{sub {ital f}}{approximately}0.6) directly obtained from integration of the divalent and trivalent portions of the 4{ital f} photoemission features indicate that these compounds are strongly mixed valent. The small intensity modulation with temperature in the divalent Yb 4{ital f} levels (0{endash}10{percent} over a {ital T}=20{minus}300 K range) is discussed within the conventional framework of the photoemission process and nominal allowances for lattice variations with temperature. Results from photoemission experiments on the divalent 4{ital f} levels of strongly correlated Yb compounds are remarkably similar to the 4{ital f} levels of purely divalent Yb metal. {copyright} {ital 1996 The American Physical Society.}

  15. Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae).

    Science.gov (United States)

    Bisio, Angela; Schito, Anna Maria; Ebrahimi, Samad Nejad; Hamburger, Matthias; Mele, Giacomo; Piatti, Gabriella; Romussi, Giovanni; Dal Piaz, Fabrizio; De Tommasi, Nunziatina

    2015-02-01

    From the aerial parts of Salvia adenophora Fernald four derivatives of 12-oxo-phytodienoic acid (1-4) together with five clerodane diterpenoids (5, 6, 8-10), and one known diterpene (7) have been isolated. Compounds 1-6 and 8-10 are described for the first time. The structures were established by extensive 1D, 2D NMR and HRESI-TOFMS spectroscopic methods. Finally, the absolute configuration has been established by comparing of experimental and quantum chemical calculation of ECD spectra. Despite a total lack of antimicrobial activity of the plant extract, hinting to the existence of antagonistic interactions in the crude material, three oxylipins (2-4) displayed a promising inhibition on Gram-positive multidrug-resistant clinical strains including Staphylococcus aureus, Streptococcus agalactiae and, particularly, Staphylococcus epidermidis, while the compounds 9 and 10 revealed a specific and strain-dependent activity against S. epidermidis. Interestingly, the inhibition provided by these compounds was independent of the resistance patterns of these pathogens to classic antibiotics. No action was reported on Gram-negative strains nor on Candida albicans. These results confirm that clerodanes and, particularly, prostaglandin-like compounds can be considered as interesting antimicrobial agents deserving further study.

  16. Screening for bioactive compounds from algae.

    Science.gov (United States)

    Plaza, M; Santoyo, S; Jaime, L; García-Blairsy Reina, G; Herrero, M; Señoráns, F J; Ibáñez, E

    2010-01-20

    In the present work, a comprehensive methodology to carry out the screening for novel natural functional compounds is presented. To do that, a new strategy has been developed including the use of unexplored natural sources (i.e., algae and microalgae) together with environmentally clean extraction techniques and advanced analytical tools. The developed procedure allows also estimating the functional activities of the different extracts obtained and even more important, to correlate these activities with their particular chemical composition. By applying this methodology it has been possible to carry out the screening for bioactive compounds in the algae Himanthalia elongata and the microalgae Synechocystis sp. Both algae produced active extracts in terms of both antioxidant and antimicrobial activity. The obtained pressurized liquid extracts were chemically characterized by GC-MS and HPLC-DAD. Different fatty acids and volatile compounds with antimicrobial activity were identified, such as phytol, fucosterol, neophytadiene or palmitic, palmitoleic and oleic acids. Based on the results obtained, ethanol was selected as the most appropriate solvent to extract this kind of compounds from the natural sources studied.

  17. Exit problems for oscillating compound Poisson process

    CERN Document Server

    Kadankova, Tetyana

    2011-01-01

    In this article we determine the Laplace transforms of the main boundary functionals of the oscillating compound Poisson process. These are the first passage time of the level, the joint distribution of the first exit time from the interval and the value of the overshoot through the boundary. Under certain conditions we establish the asymptotic behaviour of the mentioned functionals.

  18. Flavor compounds of popped amaranth seeds

    NARCIS (Netherlands)

    Gamel, T.H.; Linssen, J.P.H.

    2008-01-01

    Amaranth caudatus seeds were popped and studied for optimal popping conditions and flavor compounds. The optimum popping temperature for the seeds was 180C. At this temperature, the expansion volume, flake size and unpopped kernel proportion were 9.4¿11.3 cm3/g, 0.010¿0.012 cm/g and 10¿2%, respectiv

  19. Visualizing Compound Rotations with Virtual Reality

    Science.gov (United States)

    Flanders, Megan; Kavanagh, Richard C.

    2013-01-01

    Mental rotations are among the most difficult of all spatial tasks to perform, and even those with high levels of spatial ability can struggle to visualize the result of compound rotations. This pilot study investigates the use of the virtual reality-based Rotation Tool, created using the Virtual Reality Modeling Language (VRML) together with…

  20. Two new phenolic compounds from Ardisia gigantifolia

    Institute of Scientific and Technical Information of China (English)

    Zhu Yang; Ping Wen; Nai Li Wang; Xin Sheng Yao

    2008-01-01

    Two new compounds were isolated from the 60% ethanol extract of the dried rhizome of Ardisia gigantifolia Stapf. The structures were elucidated on the basis of spectroscopic methods as (+)-5-(1,2-dihydroxypentyl)-benzene-1,3-diol and (-)-5-(1,2-dihydroxypentyl) benzene-1,3-diol.

  1. Targeting Platinum Compounds: synthesis and biological activity

    OpenAIRE

    VAN ZUTPHEN, Steven

    2005-01-01

    Inspired by cisplatin, the inorganic drug discovered by Barnett Rosenberg in 1965, the research described in this thesis uses targeting ligands, or ligands varied in a combinatorial fashion, to find platinum complexes with more specific modes of action. These studies have lead to the development of novel (solid-phase) synthetic methods and to the discovery of several compounds with promising biological properties.

  2. Aryldicyclopentadienyltitanium compounds and their dinitrogen complexes

    NARCIS (Netherlands)

    Teuben, Jan Harmannus

    1973-01-01

    This thesis describes the synthesis and some characteristic properties of organotitanium compounds of the type Cp2TiR and the dinitrogen complexes (Cp2TiR)2N2 (R= aryl, benzyl; Cp = n-cyclopentadienyl). ... Zie: Summary

  3. Excretion of biliary compounds during intrauterine life

    Institute of Scientific and Technical Information of China (English)

    Rocio IR Macias; Jose JG Marin; Maria A Serrano

    2009-01-01

    In adults, the hepatobiliary system, together with thekidney, constitute the main routes for the eliminationof several endogenous and xenobiotic compounds intobile and urine, respectively. However, during intrauterinelife the biliary route of excretion for cholephiliccompounds, such as bile acids and biliary pigments, isvery poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of detoxifying enzymes and specific transport systems at different locations of the placental barrier, such as the endothelial cells of chorionic vessels and trophoblast cells, this organ plays an important role in the hepatobiliary-like function during intrauterine life. The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother. This may result in oxidative stress and apoptosis, mainly in the placenta and fetal liver, which might affect normal fetal development and challenge the fate of the pregnancy. The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem.

  4. Atmospheric degradation mechanism of organic sulfur compounds

    Energy Technology Data Exchange (ETDEWEB)

    Benter, T.; Arsene, C.

    2002-02-01

    In the present work a detailed product study has been performed on the OH radical initiated oxidation of dimethyl sulphide and dimethyl sulphoxide, under different conditions of temperature, partial pressure of oxygen and NO{sub x} concentration, in order to better define the degradation mechanism of the above compounds under conditions which prevail in the atmosphere. (orig.)

  5. Mutagenic compounds from chlorination of humic substances

    Science.gov (United States)

    Holmbom, Bjarne

    Chlorination of natural humic substances, as well as of lignin, produces a myriad of non-chlorinated and chlorinated compounds. The identification of an important class of strongly mutagenic compounds is reviewed. The most important Ames mutagen in chlorinated drinking waters of various origin is the compound 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone ("MX"). This compound occurs at neutral pH in the acyclic form, i.e. in the form of Z-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid. Its E-isomer (E-MX) is present in chlorinated drinking waters at a similar concentration, but is less mutagenic in Ames test. Both oxidised and reduced forms of MX and E-MX are also present in chlorinated waters. The present knowledge of the chemistry and toxicology of these mutagens is examined. The formation and possible elimination of the chlorination mutagens is discussed. The need of understanding the mechanisms of formation of these mutagens from humic substances during drinking water chlorination is emphasized.

  6. Fluorescent compounds for plastic scintillation applications

    Energy Technology Data Exchange (ETDEWEB)

    Pla-Dalmau, A.; Bross, A.D.

    1994-04-01

    Several 2-(2{prime}-hydroxyphenyl)benzothiazole, -benzoxazole, and -benzimidazole derivatives have been prepared. Transmittance, fluorescence, light yield, and decay time characteristics of these compounds have been studied in a polystyrene matrix and evaluated for use in plastic scintillation detectors. Radiation damage studies utilizing a {sup 60}C source have also been performed.

  7. A view on organocopper compounds an cuprates

    NARCIS (Netherlands)

    Koten, G. van

    1990-01-01

    Research on the chemistry and structural aspects of ortho-substituted-arylcopper and -cuprate compounds in which the ortho-substituents either interfere sterically with the C{i}{p}{s}{o}-to-copper bonding or have a potentially coordinating heteroatom, is described. Concluded is that the simple arylc

  8. Microbiological disproportionation of inorganic sulfur compounds

    DEFF Research Database (Denmark)

    Finster, Kai

    2008-01-01

    the delta subclass of Proteobacteria. The organisms grow with sulfate as their external electron acceptor and low-molecular weight organic compounds or hydrogen as energy sources. Studies of the biochemistry of a few isolates indicate that the disproportionating microbes reverse the sulfate reduction...

  9. Self injection of Dichlorvos, an Organophosphorus Compound

    Directory of Open Access Journals (Sweden)

    Sujeet Raina

    2008-07-01

    Full Text Available We report two patients who injected themselves a strong organophosphate compound, dichlorvas, and showed the typical clinical picture of organophosphate intoxication. There are very few case reports of parenteral organophosphorous poisoning. With the appropriate therapy, their symptoms disappeared in a few days. The cases are reported because of unusual and interesting way of intoxication.

  10. Teachers’ knowledge for teaching compound interest

    Directory of Open Access Journals (Sweden)

    Craig Pournara

    2013-09-01

    Full Text Available There is increasing acknowledgement that teachers’ knowledge for teaching mathematics is multifaceted and topic specific. Given the paucity of research on the teaching and learning of financial mathematics in general, little can be known about teachers’ knowledge for teaching compound interest. However, since financial mathematics is a component of the school curriculum in South Africa, and an important element of financial literacy more broadly, attention needs to be given to knowledge for teaching financial mathematics, and compound interest in particular. Drawing from a larger study in which the author taught a financial mathematics course to pre-service secondary mathematics teachers, a theoretical elaboration is provided of the underlying mathematics of compound interest, and connections with the world of banking. Based on findings from the study, two key student errors are identified: the over-generalisation of linear thinking in multiplicative scenarios, and the over-generalisation of reversible operations in percentage-change scenarios. Taken together, teachers’ knowledge of relevant mathematics, of the banking context and of learners’ conceptions will contribute to building a knowledge-base for teachers’ knowledge for teaching compound interest.

  11. Analysis of cell death inducing compounds

    DEFF Research Database (Denmark)

    Spicker, Jeppe; Pedersen, Henrik Toft; Nielsen, Henrik Bjørn

    2007-01-01

    Biomarkers for early detection of toxicity hold the promise of improving the failure rates in drug development. In the present study, gene expression levels were measured using full-genome RAE230 version 2 Affymetrix GeneChips on rat liver tissue 48 h after administration of six different compounds...... in the literature and the novel finding represents a putative hepatotoxicity biomarker....

  12. Spatial Information Capacity of Compound Eyes

    NARCIS (Netherlands)

    Snyder, Allan W.; Stavenga, Doekele G.; Laughlin, Simon B.

    1977-01-01

    The capacity of the compound eye to perceive its spatial environment is quantified by determining the number of different pictures that can be reconstructed by its array of retinula cells. We can then decide on the best compromise between an animal's capacity for fine detail and contrast sensitivity

  13. Testing of Compounds for Efficacy against Schistosomiasis.

    Science.gov (United States)

    1987-08-25

    n the snail intermediate host is Oncomelani " hnsi q u ada from the Philippine Islands. Protocol WRHN:-IIa and WRHN-IIb. A total of 31 compounds were...1978. Linhagem humana, de S fanm. resistente a esquistossomicidas. Revista de Saude Publica de Sao Paulo, 12:110. 3. Dias, L.C.S., Pedro, R.J., and

  14. Two new compounds from Trollius chinensis Bunge.

    Science.gov (United States)

    Jie-Shi, Ya; Wei-Sang, Lin; Yan, Rui; Zhao, Qiang; Zhang, Yang; Yun-Zhao, Gui; Cong-Li, Yun; Chen, Xue; Yu-Zhang, Chong; Qiao, Hua; Gang-Zhang, Guo

    2017-01-01

    Two new compounds, 2″-O-feruloylisoswertiajaponin (1) and (2E)-2-methyl-1-O-vaniloyl-4-β-D-glucopyranoside-2-butene (2), along with one indole alkaloid and five known flavonoids, were isolated from the flowers of Trollius chinensis Bunge. Their structures were elucidated on the basis of spectroscopic evidence (UV, IR, HR-ESI-MS, NMR).

  15. Study on Compound Effect of Bonded Magnets

    Institute of Scientific and Technical Information of China (English)

    Chang Ying; Ma Nuo; Yu xiaojun; Li Wei; Liu Changsheng; Lian Fazeng

    2004-01-01

    The compound effect of Nd2Fe14B/Fe3B-Ferrite bonded magnets was studied.The result shows that the value ofβjHC obviously decreases with the ferrite content increasing.In addition, a functional relation between magnetic properties and ferrite content was clearly revealed by the physical relation in the magnetic powders.

  16. Soil science: Heat-proof carbon compound

    Science.gov (United States)

    Prescott, Cindy

    2008-12-01

    Two-thirds of terrestrial carbon is stored as organic matter in soils, but its response to warming has yet to be resolved. A soil warming experiment in a Canadian forest has revealed that the leaf-derived compound cutin is resistant to decomposition under elevated temperatures.

  17. Distribution of antiherbivory compounds in Flourensia cernua

    Science.gov (United States)

    Flourensia cernua is serving as a shrub model to study the influence of terpenes on intake by livestock at this location. Two studies (n=20 plants per study) were conducted to examine within plant distribution of volatile compounds to improve sampling protocol. Leaves from 3 positions (outer canopy,...

  18. Atmospheric nitrogen compounds: Occurrence, composition and deposition

    DEFF Research Database (Denmark)

    Nielsen, T.; Pilegaard, K.; Egeløv, A.H.;

    1996-01-01

    Traffic in cities and on highways is an important contributor to NOy atmospheric pollution in open areas. In this situation both the concentration and composition of NOy compounds show a wide variation and are dependent on meteorological and atmospheric chemical conditions. The proportion of NOz...

  19. Biogenic volatile organic compounds - small is beautiful

    Science.gov (United States)

    Owen, S. M.; Asensio, D.; Li, Q.; Penuelas, J.

    2012-12-01

    While canopy and regional scale flux measurements of biogenic volatile organic compounds (bVOCs) are essential to obtain an integrated picture of total compound reaching the atmosphere, many fascinating and important emission details are waiting to be discovered at smaller scales, in different ecological and functional compartments. We concentrate on bVOCs below ground to allelopathy. A gradient of monoterpene concentration was found in soil around Pinus sylvestris and Pinus halepensis, decreasing with distance from the tree. Some compounds (α-pinene, sabinene, humulene and caryophyllene) in mineral soil were linearly correlated with the total amount of each compound in the overlying litter, indicating that litter might be the dominant source of these compounds. However, α-pinene did not fall within the correlation, indicating a source other than litter, probably root exudates. We also show that rhizosphere bVOCs can be a carbon source for soil microbes. In a horizontal gradient from Populus tremula trees, microbes closest to the tree trunk were better enzymatically equipped to metabolise labeled monoterpene substrate. Monoterpenes can also increase the degradation rate in soil of the persistant organic pollutants, likely acting as analogues for the cometabo-lism of polychlorinated biphenyls (PCBs) Flowers of a ginger species (Alpinia kwangsiensis) and a fig species (Ficus hispida) showed different bVOC signals pre- and post pollination. For Ficus hispida, there are three floral stages of a fig-wasp dependency mechanism: receptive, post pollinator and interfloral. Of 28 compounds detected, transcaryophyllene with trans-β-farnesene were the most important at the receptor stage, trans-caryophyllene was the most abundant at the post-pollinator stage, and isoprene was the most abundant in the interfloral stage. Alpinia kwangsiensis presents two morphologies for the reproductive parts of the flower. The "anaflexistyle" morphology has the flower style lowered in the

  20. Special Heusler compounds for spintronic applications

    Energy Technology Data Exchange (ETDEWEB)

    Balke, B.

    2007-07-01

    This work emphasizes the potential of Heusler compounds in a wide range of spintronic applications. Using electronic structure calculations it is possible to design compounds for specific applications. Examples for GMR and TMR applications, for spin injection into semiconductors, and for spin torque transfer applications will be shown. After a detailed introduction about spintronics and related materials chapter 5 reports about the investigation of new half-metallic compounds where the Fermi energy is tuned in the middle of the gap to result in more stable compounds for GMR and TMR applications. The bulk properties of the quaternary Heusler alloy Co{sub 2}Mn{sub 1-x}Fe{sub x}Si with the Fe concentration ranging from x=0 to 1 are reported and the results suggest that the best candidate for applications may be found at an iron concentration of about 50%. Due to the effect that in the Co{sub 2}Mn{sub 1-x}Fe{sub x}Si series the transition metal carrying the localized moment is exchanged and this might lead to unexpected effects on the magnetic properties if the samples are not completely homogeneous chapter 6 reports about the optimization of the Heusler compounds for GMR and TMR applications. The structural and magnetic properties of the quaternary Heusler alloy Co{sub 2}FeAl{sub 1-x}Si{sub x} with varying Si concentration are reported. From the combination of experimental (better order for high Si content) and theoretical findings (robust gap at x=0.5) it is concluded that a compound with an intermediate Si concentration close to x=0.5-0.7 would be best suited for spintronic applications, especially for GMR and TMR applications. In chapter 7 the detailed investigation of compounds for spin injection into semiconductors is reported. It is shown that the diluted magnetic semiconductors based on CoTiSb with a very low lattice mismatch among each other are interesting materials for spintronics applications like Spin-LEDs or other spin injection devices. Chapter 8 refers

  1. Comparative angioprotective effects of magnesium compounds.

    Science.gov (United States)

    Kharitonova, Maria; Iezhitsa, Igor; Zheltova, Anastasia; Ozerov, Alexander; Spasov, Alexander; Skalny, Anatoly

    2015-01-01

    Magnesium (Mg) deficiency is implicated in the development of numerous disorders of the cardiovascular system. Moreover, the data regarding the efficacy of different magnesium compounds in the correction of impaired functions due to low magnesium intake are often fragmentary and inconsistent. The aim of this study was to compare the effects of the most bioavailable Mg compounds (Mg l-aspartate, Mg N-acetyltaurate, Mg chloride, Mg sulphate and Mg oxybutyrate) on systemic inflammation and endothelial dysfunction in rats fed a low Mg diet for 74 days. A low Mg diet decreased the Mg concentration in the plasma and erythrocytes, which was accompanied by a reduced concentration of eNOs and increased levels of endothelin-1 level in the serum and impaired endothelium-dependent vasodilatation. These effects increased the concentration of proinflammatory molecules, such as VCAM-1, TNF-α, IL-6 and CRP, indicating the development of systemic inflammation and endothelial dysfunction. The increased total NO level, which estimated from the sum of the nitrate and nitrite concentrations in the serum, may also be considered to be a proinflammatory marker. Two weeks of Mg supplementation partially or fully normalised the ability of the vascular wall to effect adequate endothelium-dependent vasodilatation and reversed the levels of most endothelial dysfunction and inflammatory markers (except CRP) to the mean values of the control group. Mg sulphate had the smallest effect on the endothelin-1, TNF-α and VCAM-1 levels. Mg N-acetyltaurate was significantly more effective in restoring the level of eNOS compared to all other studied compounds, except for Mg oxybutyrate. Taken together, the present findings demonstrate that all Mg compounds equally alleviate endothelial dysfunction and inflammation caused by Mg deficiency. Mg sulphate tended to be the least effective compound.

  2. Student Evaluation of Online Pharmaceutical Compounding Videos.

    Science.gov (United States)

    Park, Hanna L; Shrewsbury, Robert P

    2016-03-25

    Objective. To describe pharmacy students' views on the effectiveness of an expansion of the compounding laboratory website at the UNC Eshelman School of Pharmacy. Methods. Originally, there were 39 videos and three animations available. In 2011, an additional 59 videos and two animations were added. Concurrently, all of the interactive questions were updated to fully integrate with the expanded video library. Students were surveyed about the expanded video library regarding accessibility, functionality, and usefulness, and how using the library impacted their learning of compounding. Surveys were analyzed with descriptive statistics. Means and SDs were calculated for the rating scale questions; independent t tests and Wilcoxon nonparametric tests were used to find differences between professional classes and campuses. Analytical results were evaluated with a one-way analysis of variance (ANOVA), z test, and a homogeneity of variance (Levene's) test. Results. The response rate to the survey was 85%. Compounding videos were used by 386/391 students. Thirty-four percent of students used the videos an average of 30 minutes or less per week; 56% used the videos 1-2 hours per week. Approximately 80% of students were satisfied with the functionality and accessibility of the videos. All students, regardless of professional year or campus affiliation, put their confidence/competence at about 70% of the rating scale. Conclusions. As no standardized compounding curriculum was found in US schools of pharmacy and students reported being satisfied with the website, it could be an accessible, functional, and useful resource for pharmaceutical compounding in schools of pharmacy.

  3. Spin state switching in iron coordination compounds

    Directory of Open Access Journals (Sweden)

    Philipp Gütlich

    2013-02-01

    Full Text Available The article deals with coordination compounds of iron(II that may exhibit thermally induced spin transition, known as spin crossover, depending on the nature of the coordinating ligand sphere. Spin transition in such compounds also occurs under pressure and irradiation with light. The spin states involved have different magnetic and optical properties suitable for their detection and characterization. Spin crossover compounds, though known for more than eight decades, have become most attractive in recent years and are extensively studied by chemists and physicists. The switching properties make such materials potential candidates for practical applications in thermal and pressure sensors as well as optical devices.The article begins with a brief description of the principle of molecular spin state switching using simple concepts of ligand field theory. Conditions to be fulfilled in order to observe spin crossover will be explained and general remarks regarding the chemical nature that is important for the occurrence of spin crossover will be made. A subsequent section describes the molecular consequences of spin crossover and the variety of physical techniques usually applied for their characterization. The effects of light irradiation (LIESST and application of pressure are subjects of two separate sections. The major part of this account concentrates on selected spin crossover compounds of iron(II, with particular emphasis on the chemical and physical influences on the spin crossover behavior. The vast variety of compounds exhibiting this fascinating switching phenomenon encompasses mono-, oligo- and polynuclear iron(II complexes and cages, polymeric 1D, 2D and 3D systems, nanomaterials, and polyfunctional materials that combine spin crossover with another physical or chemical property.

  4. Production of the rare ginsenosides compound K, compound Y, and compound Mc by a thermostable beta-glycosidase from Sulfolobus acidocaldarius.

    Science.gov (United States)

    Noh, Kyeong-Hwan; Oh, Deok-Kun

    2009-11-01

    The rare ginsenosides compound K, compound Y, and compound Mc were produced from the major ginsenosides Rb(1), Rb(2), Rc, and Rd by a thermostable beta-glycosidase from Sulfolobus acidocaldarius via three pathways: Rb(1)-->Rd-->compound K, Rb(2)-->compound Y-->compound K, and Rc-->compound Mc. Each of the ginsenosides was identified by high-performance liquid chromatography using standards and liquid chromatography-mass spectrometry based on their molecular weights. The catalytic efficiency of the enzyme for ginsenosides followed the order Rb(1) (4.8)>Rc (4.5)>Rd (1.0)>Rb(2) (0.77 mM(-1) min(-1)). The enzyme converted 1 mg/ml reagent-grade Rb(1), Rb(2), and Rc to 0.53 mg/ml compound K, 0.56 mg/ml compound Y, and 0.70 mg/ml compound Mc, respectively, at pH 5.5 and 85 degrees C after 180 min, corresponding to mole conversion yields of 94, 80, and 100% (mol/mol), respectively. The enzyme converted the major ginsenosides Rb(1), Rb(2), Rc, and Rd in 10% (w/v) ginseng root extract to the rare ginsenosides with a mole yield of 99% after 24 h. These results suggest that beta-glycosidase from S. acidocaldarius can be used to produce compound K, compound Y, and compound Mc.

  5. Human biological monitoring of suspected endocrine-disrupting compounds

    OpenAIRE

    Moosa Faniband; Lindh, Christian H; Bo AG Jönsson

    2014-01-01

    Endocrine-disrupting compounds are exogenous agents that interfere with the natural hormones of the body. Human biological monitoring is a powerful method for monitoring exposure to endocrine disrupting compounds. In this review, we describe human biological monitoring systems for different groups of endocrine disrupting compounds, polychlorinated biphenyls, brominated flame retardants, phthalates, alkylphenols, pesticides, metals, perfluronated compounds, parabens, ultraviolet filters, and o...

  6. Synthesis, Chemistry, and Applications of Heterocyclic Cage Compounds (V)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ The synthesis and chemistry of polycyclic of cage compounds have attracted considerable attention in recent years. The vast majority of the work reported in this area has dealt with carbocylic cage compounds. On the other hand, the synthesis and chemistry of heterocyclic cage compounds have received less attention. Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.1 As part of a program that involves the synthesis, chemistry, and application of heterocyclic cage compounds, we report here the synthesis of new thia-oxa-cage compounds and the chemical nature of these thia-cages.

  7. A New Nonlinear Compound Forecasting Method Based on ANN

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this paper the compound-forecasting method is discussed. The compound-forecasting method is one of the hotspots in the current predication. Firstly, the compound-forecasting method is introduced and various existing compound-forecasting methods arediscussed. Secondly, the Artificial Neural Network (ANN) is brought in compound-prediction research and a nonlinear compound-prediction model based on ANN is presented. Finally, inorder to avoid irregular weight, a new method is presented which uses principal component analyses to increase the availability of compound-forecasting information. Higherforecasting precision is achieved in practice.

  8. THE COMPOUND NOUNS BETWEEN ENGLISH AND ALBANIAN LANGUAGE

    OpenAIRE

    Shkelqim Millaku; Xhevahire Topanica

    2016-01-01

    The compound words are all the words that are compound from two or more words and both of them creative the new words with the new meaning. In linguistics, a compound is a lexeme (less precisely, a word) that consists of more than one stem. Compounding or composition is the word-formation that creates compound lexemes (the other word-formation process being derivation). Compounding or Word-compounding refers to the faculty and device of language to form new words by combining or putting toget...

  9. Raman scattering in transition metal compounds: Titanium and compounds of titanium

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, J.; Ederer, D.L.; Shu, T. [Tulane Univ., New Orleans, LA (United States)] [and others

    1997-04-01

    The transition metal compounds form a very interesting and important set of materials. The diversity arises from the many states of ionization the transition elements may take when forming compounds. This variety provides ample opportunity for a large class of materials to have a vast range of electronic and magnetic properties. The x-ray spectroscopy of the transition elements is especially interesting because they have unfilled d bands that are at the bottom of the conduction band with atomic like structure. This group embarked on the systematic study of transition metal sulfides and oxides. As an example of the type of spectra observed in some of these compounds they have chosen to showcase the L{sub II, III} emission and Raman scattering in some titanium compounds obtained by photon excitation.

  10. A New Compound Along With Seven Known Compounds from an Endophytic Fungus Aspergillus sp. HS-05

    Directory of Open Access Journals (Sweden)

    Gang Chen

    2013-08-01

    Full Text Available Investigation of EtOAc extract from the fermentation broth of the endophytic fungus Asperilligus sp. HS-05 led to the isolation of a new compound (1 of spiro moiety named aspergispiroketal and seven known compounds (2-8. Their structures were elucidated mainly by NMR and HR-TOF-MS, as well as on comparison with the reported data. The absolute configuration of 1 was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.

  11. Quaternary ammonium compounds – New occupational hazards

    Directory of Open Access Journals (Sweden)

    Agnieszka Lipińska-Ojrzanowska

    2014-10-01

    Full Text Available Quaternary ammonium compounds (QACs, quats belong to organic ionic chemical agents which display unique properties of both surfactants and disinfectants. Their wide distribution in the work environment and also in private households brings about new occupational hazards. This paper reviews reports about the health effects of QACs. QACs could play a role of sensitizers and irritants to the skin and mucous membranes. It is suspected that particular QACs can display an immunologic crossreactivity between each other and with other chemical compounds containing ammonium ion, such as muscle relaxants widely used in anesthesia. They may promote the development of airway allergy, however, the background mechanisms are still unclear and need to be further investigated. Until now, a few cases of occupational asthma induced by QACs have been described and their involvement in contact dermatitis has been documented. The possibility of anaphylaxis due to QACs cannot be excluded as well. Med Pr 2014;65(5:675–682

  12. Compound Composite Odontoma and Its Management

    Directory of Open Access Journals (Sweden)

    Morawala Abdul

    2014-01-01

    Full Text Available Odontomas are odontogenic benign tumors composed of dental tissue. Majority of these lesions are asymptomatic and are often detected on routine radiographs. They can be thought of as “tooth hamartomas" with the lesion consisting of various tooth components. They are divided histologically into complex odontomas and compound odontomas. This paper describes the case of a compound odontoma in a 13-year-old girl diagnosed due to the retention of the primary right mandibular second molar. A surgical excision was performed without disturbing the unerupted premolar. The results achieved indicate that early diagnosis of odontomas enables adoption of less complex treatment, a better prognosis, and displacement or devitalisation of adjacent tooth.

  13. NOVEL BIOACTIVE COMPOUNDS FROM MANGROVE DERIVED ACTINOMYCETES

    Directory of Open Access Journals (Sweden)

    Kumari Amrita

    2012-09-01

    Full Text Available Mangrove is most productive and unexplored ecosystem that approximately covers one fourth of world coastline with high diversity of thriving organism. Recently the rate of isolation of novel bioactive compounds from microorganism living in mangrove forest has tremendously increased which is reflected in significant hasten for exploration of mangrove actinomycetes. Actinomycetes are group of bacteria which are extremely interesting as active producers of many primary and secondary metabolites. Many survey reports has depicted that the biologically active compounds which have been obtained so far from microbes, 45 percent are produced by actinomycetes, 38 percent by fungi and 17 percent by unicellular bacteria. Actinomycetes from mangrove environment provide diverse and are potential rich source of antibiotics, anticancer, antifungal and antiviral agent, enzyme and enzyme inhibitor. Mangrove actinomycetes are a prolific but underexploited source for the discovery of novel secondary metabolites.

  14. Electrical Properties of Expanded Graphite Intercalation Compounds

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The intercalation compounds of CuCl2 were synthesized with expanded graphite, whose magnitude of the electrical conductivity is about 103S.cm-1. Their electrical conductivity is 3~6 times as high as that of the expanded graphite, and about 10 times as high as that of GIC made of the non-expanded graphite. The microanalysis results of chemical compounds by X-ray energy spectrum scanning of TEM testified that the atomic ratio of chloride and cupric is nonstoichoimetric. The multivalence and exchange of electrovalence of the cupric ion was confirmed by the XPS-ESCA. Vacancy of chlorine anion increases the concentration of charge carrier.The special stage structure, made of graphite and chloride, produces a weak chemical bond belt and provides a carrier space in the direction of GIC layer. These factors develop the electrical properties.

  15. Volatile compounds of commercial Milano salami.

    Science.gov (United States)

    Meynier, A; Novelli, E; Chizzolini, R; Zanardi, E; Gandemer, G

    1999-02-01

    The relationship between extracted volatiles of Milano salami, one of the main dry-cured sausages produced in Italy, and their olfactory properties was studied. Volatile compounds were extracted by a purge-and-trap method, quantified using a flame ionisation detector and identified by mass spectrometry. Olfactory analysis was performed by sniffing the gas chromatographic effluent. Nearly 80 compounds were identified and quantified: most came from spices (60.5%), 18.9% from lipid oxidation, 11.8% from amino acid catabolism and 4.9% from fermentation processes. Panellists detected 19 odours by sniffing. These odours were associated with spices, lipid oxidation or fermentation and were in agreement with the contributions of each reaction to the overall aroma of the product.

  16. Oxyfluoride Chemistry of Layered Perovskite Compounds

    Directory of Open Access Journals (Sweden)

    Yoshihiro Tsujimoto

    2012-03-01

    Full Text Available In this paper, we review recent progress and new challenges in the area of oxyfluoride perovskite, especially layered systems including Ruddlesden-Popper (RP, Dion-Jacobson (DJ and Aurivillius (AV type perovskite families. It is difficult to synthesize oxyfluoride perovskite using a conventional solid-state reaction because of the high chemical stability of the simple fluoride starting materials. Nevertheless, persistent efforts made by solid-state chemists have led to a major breakthrough in stabilizing such a mixed anion system. In particular, it is known that layered perovskite compounds exhibit a rich variety of O/F site occupation according to the synthesis used. We also present the synthetic strategies to further extend RP type perovskite compounds, with particular reference to newly synthesized oxyfluorides, Sr2CoO3F and Sr3Fe2O5+xF2−x (x ~ 0.44.

  17. Reactive spreading: Adsorption, ridging and compound formation

    Energy Technology Data Exchange (ETDEWEB)

    Saiz, E.; Cannon, R.M.; Tomsia, A.P.

    2000-09-11

    Reactive spreading, in which a chemically active element is added to promote wetting of noble metals on nonmetallic materials, is evaluated. Theories for the energetics and kinetics of the necessary steps involved in spreading are outlined and compared to the steps in compound formation that typically accompany reactive wetting. These include: fluid flow, active metal adsorption, including nonequilibrium effects, and triple line ridging. All of these can be faster than compound nucleation under certain conditions. Analysis and assessment of recently reported experiments on metal/ceramic systems lead to a focus on those conditions under which spreading proceeds ahead of the actual formation of a new phase at the interface. This scenario may be more typical than believed, and perhaps the most effective situation leading to enhanced spreading. A rationale for the pervasive variability and hysteresis observed during high temperature wetting also emerges.

  18. [Today's threat of use of organophosphorus compounds].

    Science.gov (United States)

    Sokołowski, Rafał; Płusa, Tadeusz

    2015-09-01

    Organophosphates are stable cholinesterases inhibitors (AChE). Inhibition of AChE activity leads to the accumulation of large amounts of acetylcholine and hyperactivity of the cholinergic system by stimulating acetylcholine receptors - muscarinic and nicotinic. This group included tabun, sarin, soman and VX gases. Exposure to gaseous form causes symptoms within a few seconds of exposure. This depends on the gas concentration in the atmosphere. The most sensitive organ is the eyes and the respiratory system. Severe poisoning are characterized by the immediate loss of consciousness with convulsions. Therapeutic management of acute poisoning organophosphorus compounds boils down to treating symptomatic and supportive vital functions. Monitoring of cardiovascular, respiratory and renal failure in intensive care gives only guarantee the effective treatment of poisoning. Properties toxic organophosphorus compounds also are of interest to terrorist groups.

  19. Synthesis and properties of trifluoromethylating steroid compounds

    Institute of Scientific and Technical Information of China (English)

    王钟麒; 卢寿福; 张建蓉

    1997-01-01

    Trifluoromethyl steroids la,b; 2a,b; 3a,b have been synthesized by starting from estren 3,17-dicarbonyl-3,3-dimethyl ether (4) and dl-18-methyl-2(3)l5(10)-estra-diene-17-carbonyl-3-methyl ether (5),and by using trimthyltrifluoromethylsilane as the trifluoromethylating agent under the catalysis of tetrarnethylam-monium fluoride.The overall yields were 82%,76%; 54%,62%; and 27%,25%,respectively The α-configura tion of trifluoromethyl group of 17-position was determined by X-ray crystal diffraction method Compounds 1a,2a and 3a showed high affinity for rat uterus PRc.The test of biological activities of compounds 1b,2b and 3b is proceeding.

  20. Screening Some Plants for their Antiproliferative Compounds

    Directory of Open Access Journals (Sweden)

    Ufuk Kolak

    2012-03-01

    Full Text Available This paper covers the screening of the secondary plant products to find a cure against cancer which were piled up during the years. In early stages of these studies highly active antitumor glycoproteins were obtained from native Arizona (USA plants. Later smaller molecules were isolated showing antitumor activity in different test systems. Among these compounds sesquiterpene lactones with an exo-methylene group in the lactone ring, unsaturated diterpenoids and some triterpenoids exhibited activity in vivo and in vitro test systems. A few Colchicum alkaloids showed high activity against murine lymphocytic leukemia (P388. Activity also established in some flavonoidal compounds. Today all around the world research on Natural Products is still going on.

  1. Intercalation compounds involving inorganic layered structures

    Directory of Open Access Journals (Sweden)

    CONSTANTINO VERA R. L.

    2000-01-01

    Full Text Available Two-dimensional inorganic networks can shown intracrystalline reactivity, i.e., simple ions, large species as Keggin ions, organic species, coordination compounds or organometallics can be incorporated in the interlayer region. The host-guest interaction usually causes changes in their chemical, catalytic, electronic and optical properties. The isolation of materials with interesting properties and making use of soft chemistry routes have given rise the possibility of industrial and technological applications of these compounds. We have been using several synthetic approaches to intercalate porphyrins and phthalocyanines into inorganic materials: smectite clays, layered double hydroxides and layered niobates. The isolated materials have been characterized by elemental and thermal analysis, X-ray diffraction, surface area measurements, scanning electronic microscopy, electronic and resonance Raman spectroscopies and EPR. The degree of layer stacking and the charge density of the matrices as well their acid-base nature were considered in our studies on the interaction between the macrocycles and inorganic hosts.

  2. Photocatalytic oxidation of organic compounds on Mars

    Science.gov (United States)

    Chun, S. F. S.; Pang, K. D.; Cutts, J. A.; Ajello, J. M.

    1978-01-01

    Ultraviolet-stimulated catalytic oxidation is proposed as a mechanism for the destruction of organic compounds on Mars. The process involves the presence of gaseous oxygen, UV radiation, and a catalyst (titanium dioxide), and all three of these have been found to be present in the Martian environment. Therefore it seems plausible that UV-stimulated oxidation of organics is responsible for degrading organic molecules into inorganic end products.

  3. Cometary micrometeorites and input of prebiotic compounds

    OpenAIRE

    2014-01-01

    The apparition of life on the early Earth was probably favored by inputs of extraterrestrial matter brought by carbonaceous chondrite-like objects or cometary material. Interplanetary dust collected nowadays on Earth is related to carbonaceous chondrites and to cometary material. They contain in particular at least a few percent of organic matter, organic compounds (amino-acids, PAHs,…), hydrous silicates, and could have largely contributed to the budget of prebiotic matter on Earth, about 4 ...

  4. Growing Single Crystals of Compound Semiconductors

    Science.gov (United States)

    Naumann, Robert J.; Lehoczky, Sandor L.; Frazier, Donald O.

    1987-01-01

    Defect reduced by preventing melt/furnace contact and suppressing convention. Large crystals of compound semiconductors with few defects grown by proposed new method. Such materials as gallium arsenide and cadmium telluride produced, with quality suitable for very-large-scale integrated circuits or for large focal-plane arrays of photodetectors. Method used on small scale in Earth gravity, but needs microgravity to provide crystals large enough for industrial use.

  5. Novel ocular antihypertensive compounds in clinical trials

    Directory of Open Access Journals (Sweden)

    Chen J

    2011-05-01

    Full Text Available June Chen1, Stephen A Runyan1, Michael R Robinson21Department of Biological Sciences, 2Ophthalmology Clinical Research, Allergan, Inc, Irvine, CA, USAIntroduction: Glaucoma is a multifactorial disease characterized by progressive optic nerve injury and visual field defects. Elevated intraocular pressure (IOP is the most widely recognized risk factor for the onset and progression of open-angle glaucoma, and IOP-lowering medications comprise the primary treatment strategy. IOP elevation in glaucoma is associated with diminished or obstructed aqueous humor outflow. Pharmacotherapy reduces IOP by suppressing aqueous inflow and/or increasing aqueous outflow.Purpose: This review focuses on novel non-FDA approved ocular antihypertensive compounds being investigated for IOP reduction in ocular hypertensive and glaucoma patients in active clinical trials within approximately the past 2 years.Methods: The mode of IOP reduction, pharmacology, efficacy, and safety of these new agents were assessed. Relevant drug efficacy and safety trials were identified from searches of various scientific literature databases and clinical trial registries. Compounds with no specified drug class, insufficient background information, reformulations, and fixed-combinations of marketed drugs were not considered.Results: The investigational agents identified comprise those that act on the same targets of established drug classes approved by the FDA (ie, prostaglandin analogs and β-adrenergic blockers as well as agents belonging to novel drug classes with unique mechanisms of action. Novel targets and compounds evaluated in clinical trials include an actin polymerization inhibitor (ie, latrunculin, Rho-associated protein kinase inhibitors, adenosine receptor analogs, an angiotensin II type 1 receptor antagonist, cannabinoid receptor agonists, and a serotonin receptor antagonist.Conclusion: The clinical value of novel compounds for the treatment of glaucoma will depend

  6. Aromatic compounds from three Brazilian Lauraceae species

    Energy Technology Data Exchange (ETDEWEB)

    Batista, Andrea Nastri de Luca; Batista Junior, Joao Marcos; Lopez, Silvia Noeli; Furlan, Maysa; Cavalheiro, Alberto Jose; Silva, Dulce Helena Siqueira; Bolzani, Vanderlan da Silva [UNESP, Araraquara, SP (Brazil). Inst. de Quimica. Dept. de Quimica Organica; Nunomura, Sergio Massayoshi [Instituto Nacional de Pesquisa da Amazonia (INPA), Manaus, AM (Brazil). Dept. de Produtos Naturais; Yoshida, Massayoshi [Centro de Biotecnologia da Amazonia, Manaus, AM (Brazil)

    2010-07-01

    Phytochemical investigations on three Brazilian Lauraceae species from the Cerrado region of Sao Paulo State, Ocotea corymbosa (Meins) Mez., O. elegans Mez. and Persea pyrifolia Nees and Mart. ex Nees resulted in the isolation of flavonoids, an ester of the 4-O-E-caffeoylquinic acid, an aromatic sesquiterpene besides furofuran lignans. This is the first chemical study on the leaves of Ocotea elegans and O. corymbosa as well as the first report of non-volatile compounds from Persea pyrifolia. (author)

  7. Fungal Endophthalmitis Associated with Compounded Products

    OpenAIRE

    Mikosz, Christina A.; Rachel M. Smith; Kim, Moon; Tyson, Clara; Lee, Ellen H.; Adams, Eleanor; Straif-Bourgeois, Susanne; Sowadsky, Rick; Arroyo, Shannon; Grant-Greene, Yoran; Duran, Julie; Vasquez, Yvonne; Robinson, Byron F.; Harris, Julie R.; Lockhart, Shawn R.

    2014-01-01

    Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck’s Compounding Lab (Oc...

  8. Characterization of A New Organic Photochromic Compound

    Institute of Scientific and Technical Information of China (English)

    LIU,Guang-Fei; LIU,Lang; JIA,Dian-Zeng; HU,Xin; YU,Kai-Bei

    2004-01-01

    @@ A new organic photochromic compound, 1-phenyl-3-methyl-4-(4-fluoro)-benzal-5-pyrazolone ethanyl-thiosemicarbazone (PM4FBP-ETSC) was found to undergo photochromic reactions in the solid state. Upon irradiation with 365nm light the white powder sample turned light yellow. The photochromic properties were characterized by the time-dependent UV-vis reflective spectra. The structure of PM4FBP-ETSC was determined by single crystal X-ray diffraction.

  9. Basics of compounding foam dosage forms.

    Science.gov (United States)

    Allen, Loyd V

    2013-01-01

    The purpose of this article is to provide information on the use of foam dosage forms and pharmacists' ability to extemporaneously compound them. The article provides: (1) a discussion on the rationale and advantages of using foams, (2) a differentiation between the various types and structures of foams, (3) a list of the various types of ingredients and examples of each, and (4) a description of the preparation of pharmaceutical foams.

  10. Antimalarial compounds from Kniphofia foliosa roots.

    Science.gov (United States)

    Wube, Abraham Abebe; Bucar, Franz; Asres, Kaleab; Gibbons, Simon; Rattray, Lauren; Croft, Simon L

    2005-06-01

    During the course of screening Ethiopian medicinal plants for their antimalarial properties, it was found that the dichloromethane extract of the roots of Kniphofia foliosa Hochst. (Asphodelaceae), which have long been used in the traditional medicine of Ethiopia for the treatment of abdominal cramps and wound healing, displayed strong in vitro antiplasmodial activity against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum with an ED50 value of 3.8 microg/mL and weak cytotoxic activity against KB cells with an ED50 value of 35.2 microg/mL. Five compounds were isolated from the roots and evaluated for their in vitro antimalarial activity. Among the compounds tested, 10-(chrysophanol-7'-yl)-10-(xi)-hydroxychrysopanol-9-anthrone and chryslandicin, showed a high inhibition of the growth of the malaria parasite, P. falciparum with ED50 values of 0.260 and 0.537 microg/mL, respectively, while the naphthalene derivative, 2-acetyl-1-hydroxy-8-methoxy-3-methylnaphthalene, exhibited a less significant antimalarial activity with an ED50 value of 15.4 microg/mL. To compare the effect on the parasite with toxicity to mammalian cells, the cytotoxic activities of the isolated compounds against the KB cell line were evaluated and 10-(chrysophanol-7'-yl)-10-(xi)-hydroxychrysopanol-9-anthrone and chryslandicin displayed very low toxicity with ED50 values of 104 and 90 microg/mL, respectively. This is the first report of the inhibition of the growth of P. falciparum by anthraquinone-anthrone dimers and establishes them as a new class of potential antimalarial compounds with very little host cell toxicity.

  11. Effect of intermediate compounds and products on wet oxidation and biodegradation rates of pharmaceutical compounds.

    Science.gov (United States)

    Collado, Sergio; Laca, Adriana; Diaz, Mario

    2013-06-01

    Kinetics of pure compounds in batch agitated reactors are useful data to clarify the characteristics of a given reaction, but they frequently do not provide the required information to design industrial mixed continuous processes because in this case the final and intermediate products interact with the reaction of interest, due to backmixing effects. Simultaneously, the presence and transformations of other compounds, frequent in industrial wastewater treatments, adds more complexity to these types of interactions, whose effect can be different, favorable or unfavorable, for chemical or biological reactions. In this work, batch laboratory reactor data were obtained for the wet oxidation and biodegradation of four phenolic compounds present in a pharmaceutical wastewater and then compared with those collected from industrial continuous stirred tank reactors. For wet oxidation, batch laboratory degradation rates were significantly lower than those found in industrial continuous stirred operation. This behavior was explained by a different distribution of intermediate compounds in lab and industrial treatments, caused by the degree of backmixing and the synergistic effects between phenolic compounds (matrix effects). On the other hand, the specific utilization rates during aerobic biodegradation in the continuous industrial operation were lower than those measured in the laboratory, due to the simultaneous presence of the four pollutants in the industrial process (matrix effects) increasing the inhibitory effects of these compounds and its intermediates.

  12. Raman spectroscopy for analysis of thorium compounds

    Science.gov (United States)

    Su, Yin-Fong; Johnson, Timothy J.; Olsen, Khris B.

    2016-05-01

    The thorium fuel cycle is an alternative to the uranium fuel cycle in that when 232Th is irradiated with neutrons it is converted to 233U, another fissile isotope. There are several chemical forms of thorium which are used in the Th fuel cycle. Recently, Raman spectroscopy has become a very portable and facile analytical technique useful for many applications, including e.g. determining the chemical composition of different materials such as for thorium compounds. The technique continues to improve with the development of ever-more sensitive instrumentation and better software. Using a laboratory Fourier-transform (FT)-Raman spectrometer with a 785 nm wavelength laser, we were able to obtain Raman spectra from a series of thorium-bearing compounds of unknown origin. These spectra were compared to the spectra of in-stock-laboratory thorium compounds including e.g. ThO2, ThF4, Th(CO3)2 and Th(C2O4)2. The unknown spectra showed very good agreement to the known standards, demonstrating the applicability of Raman spectroscopy for detection and identification of these nuclear materials.

  13. Natural Biodegradation of Phenolic Compounds in Groundwater

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A combination of field data and theoretical approaches is used to assess the natural attenuation and status of a complex plume of phenolic compounds (phenol, cresols, xylenols) in a deep, consolidated, UK Permo-Triassic sandstone aquifer. Biodegradation of the phenolic compounds at concentrations up to 12500mg·L-1 is occurring under aerobic, NO-3-reducing, Mn/Fe-reducing, SO2-4-reducing and methanogenic conditions in the aquifer, with the accumulation of inorganic and organic metabolites in the plume. An electron and carbon balance for the plume suggests that only 6% of the source term has been degraded in 50 years. The residual contaminant mass in the plume significantly exceeds estimates of electron acceptor inputs, indicating that the plume will grow. Two detailed vertical profiles through the plume show that contaminant distributions are controlled more by source history than by biodegradation processes. Microbiological and mass balance studies show that biodegradation is greatest at the plume fringe where contaminant concentrations are diluted by transverse mixing. Active bacterial populations exist throughout the plume but biodegradation is inhibited in the plume core by high contaminant concentrations. Stable isotope studies show that SO2-4-reduction is particularly sensitive to contaminant concentration. The aquifer is not oxidant-deficient but natural attenuation of the phenolic compounds in this system is limited by toxicity from the pollutant load and the bioavailability of electron acceptors. Natural attenuation of these contaminants will increase only after increased dilution of the plume.

  14. Chlorinated organic compounds in urban river sediments

    Energy Technology Data Exchange (ETDEWEB)

    Soma, Y.; Shiraishi, H.; Inaba, K. [National Inst. of Environmental Studies, Tsukuba, Ibaraki (Japan)

    1995-12-31

    Among anthropogenic chemicals, many chlorinated organic compounds have been used as insecticides and detected frequently as contaminants in urban river sediments so far. However, the number and total amount of chemicals produced commercially and used are increasing year by year, though each amount of chemicals is not so high. New types of contaminants in the environment may be detected by the use of newly developed chemicals. Chlorinated organic compounds in the urban river sediments around Tokyo and Kyoto, large cities in Japan, were surveyed and recent trends of contaminants were studied. Contaminants of the river sediments in industrial areas had a variety, but PCB (polychlorinated biphenyls) was detected in common in industrial areas. Concentration of PCB related well to the number of factories on both sides of rivers, although the use of PCB was stopped 20 years ago. In domestic areas, Triclosan (5-chloro-2-(2,4-dichlorophenoxy)-phenol) and Triclocarban (3,4,4{prime}-trichlorocarbanilide)(both are contained in soap or shampoo for fungicides), p-dichlorobenzene (insecticides for wears) and TCEP(tris-chloroethyl phosphate) were detected. EOX(extracted organic halogen) in the sediments was 5 to 10 times of chlorinated organic compounds detected by GC/MS. Major part of organic halogen was suggested to be included in chlorinated organics formed by bleaching or sterilization.

  15. Antimicrobial compounds from Coleonema album (Rutaceae).

    Science.gov (United States)

    Esterhuizen, Lindy L; Meyer, Riaan; Dubery, Ian A

    2006-01-01

    Coleonema album, a member of the South African fynbos biome, was evaluated for its antimicrobial activity associated with its secondary metabolites. Ethanol- and acetone-based extracts obtained from plants from two different geographical areas were analyzed. A bioassay-guided fractionation methodology was followed for rapid and effective screening for the presence of bioactive compounds. The TLC-bioautographic method, used to screen the plant extracts for antimicrobial activity and localization of the active compounds, indicated the presence of a number of inhibitory compounds with activity against the microorganisms (E. coli, B. subtilis, E. faecalis, P. aeruginosa, S. aureus, M. smegmatis, M. tuberculosis, C. albicans, C. cucumerinum) tested. Evaluation of the inhibitory strength of each extract by the serial microdilution assay indicated that the C. album extracts inhibited effectively all the microorganisms, with the minimum inhibitory concentrations in the low mg ml(-1) range. Identification and structural information of the bioactive components were obtained by a combination of preparative TLC and LC-MS. It revealed the presence of coumarin aglycones which were responsible for the observed antimicrobial activities. The results of this study indicate that C. album possesses strong antimicrobial activity against a wide range of microorganisms that warrants further investigation into the use of the extracts or their active constituents as a potential source for novel drugs.

  16. of polyphenolic compounds in Ilex Sp.

    Directory of Open Access Journals (Sweden)

    Zwyrzykowska Anna

    2015-11-01

    Full Text Available Natural compounds are an important source of desired biological activity which help to improve nutritional status, enhance productivity and bring many health benefits. The leaves of the Ilex paraguariensis (Aquifoliaceae are used for preparing a beverage known as yerba mate and represent a proven source of natural polyphenols which are known to foster biological activity with the emphasis on antioxidant properties. In present work we focused on the polyphenolic content of air-dried leaves of Ilex aquifolium L., Ilex aquifolium ‘Argentea Mariginata’, Ilex meserveae ‘Blue Angel’, and a commercially available mate as the reference product. Liquid chromatography combined with mass spectrometry (HPLC and LC-MS and thin layer chromatography (TLC, were used to establish polyphenolic substances content in aqueous methanolic extracts obtained from the biological matter. Up to 20 polyphenolic compounds were identified in the extracts, including rutin, quinic acid and its caffeoyl esters, i.e. chlorogenic acid and its isomers as well as dicaffeoyl derivatives. We took chlorogenic acid and rutin as reference compounds to quantify their levels in the extracts. It was determined that in all tested plants, high levels of these antioxidants were present. This led us to the conclusion that their leaves might serve as valuable food additives.

  17. Activity of Polyphenolic Compounds against Candida glabrata

    Directory of Open Access Journals (Sweden)

    Ricardo Salazar-Aranda

    2015-09-01

    Full Text Available Opportunistic mycoses increase the morbidity and mortality of immuno-compromised patients. Five Candida species have been shown to be responsible for 97% of worldwide cases of invasive candidiasis. Resistance of C. glabrata and C. krusei to azoles has been reported, and new, improved antifungal agents are needed. The current study was designed to evaluatethe activity of various polyphenolic compounds against Candida species. Antifungal activity was evaluated following the M27-A3 protocol of the Clinical and Laboratory Standards Institute, and antioxidant activity was determined using the DPPH assay. Myricetin and baicalein inhibited the growth of all species tested. This effect was strongest against C. glabrata, for which the minimum inhibitory concentration (MIC value was lower than that of fluconazole. The MIC values against C. glabrata for myricitrin, luteolin, quercetin, 3-hydroxyflavone, and fisetin were similar to that of fluconazole. The antioxidant activity of all compounds was confirmed, and polyphenolic compounds with antioxidant activity had the greatest activity against C. glabrata. The structure and position of their hydroxyl groups appear to influence their activity against C. glabrata.

  18. Bismuth nanoparticles for phenolic compounds biosensing application.

    Science.gov (United States)

    Mayorga-Martinez, Carmen C; Cadevall, Miquel; Guix, Maria; Ros, Josep; Merkoçi, Arben

    2013-02-15

    The rapid determination of trace phenolic compounds is of great importance for evaluating the total toxicity of contaminated water samples. Nowadays, electrochemical tyrosinase (Tyr) based biosensors constitute a promising technology for the in situ monitoring of phenolic compounds because of their advantages such as high selectivity, low production cost, promising response speed, potential for miniaturization, simple instrumentation and easy automatization. A mediator-free amperometric biosensor for phenolic compounds detection based on the combination of bismuth nanoparticles (BiNPs) and Tyr for phenol detections will be hereby reported. This is achieved through the integration of BiNPs/Tyr onto the working electrode of a screen printed electrode (SPE) by using glutaraldehyde as a cross-linking agent. BiNPs/Tyr biosensor is evaluated by amperometric measurements at -200 mV DC and a linear range of up to 71 μM and 100 μM and a correlation coefficient of 0.995 and 0.996 for phenol and catechol, respectively. The very low DC working potential ensures the avoidance of interferences making this biosensor an advantageous device for real sample applications. In addition, the response mechanism including the effect of BiNPs based on electrochemical studies and optical characterizations will be also discussed. The obtained results may open the way to many other BiNPs applications in the biosensing field.

  19. A Novel Antibacterial Compound from Siegesbeckia glabrescens

    Directory of Open Access Journals (Sweden)

    Deokhoon Park

    2012-10-01

    Full Text Available The crude methanol extract of the dried aerial parts of Siegesbeckia glabrescens (Compositae showed antibacterial activity against the foodborne pathogen Staphylococcus aureus. Bioactivity-guided separation led to the isolation of 3-(dodecanoyloxy-2-(isobutyryloxy-4-methylpentanoic acid from nature for the first time. The structure was determined by spectroscopic data analysis (UV, MS, and NMR. The minimal inhibitory concentration (MIC of 3-(dodecanoyloxy-2-(isobutyryloxy-4-methylpentanoic acid against S. aureus was found to be 3.12 μg/mL. In addition, in a further antimicrobial activity assay against Gram-positive (B. subtilis, E. faecalis, P. acnes, S. epidermidis, S. schleiferi subsp. coagulans, S. agalactiae and S. pyrogens, and Gram-negative bacteria (E. coli and P. aeruginosa, and yeast strains (C. alibicans and F. neoformans, the antimicrobial activity of the compound was found to be specific for Gram-positive bacteria. The MIC values of the compound for Gram-positive bacteria ranged from 3.12 to 25 mg/mL. Furthermore, it was found that the 2-(isobutyryloxy-4-methylpentanoic acid substituent may operate as a key factor in the antibacterial activity of the compound, together with the laurate group.

  20. Enzyme catalytic nitration of aromatic compounds.

    Science.gov (United States)

    Kong, Mingming; Wang, Kun; Dong, Runan; Gao, Haijun

    2015-06-01

    Nitroaromatic compounds are important intermediates in organic synthesis. The classic method used to synthesize them is chemical nitration, which involves the use of nitric acid diluted in water or acetic acid, both harmful to the environment. With the development of green chemistry, environmental friendly enzyme catalysis is increasingly employed in chemical processes. In this work, we adopted a non-aqueous horseradish peroxidase (HRP)/NaNO2/H2O2 reaction system to study the structural characteristics of aromatic compounds potentially nitrated by enzyme catalysis, as well as the relationship between the charges on carbon atoms in benzene ring and the nitro product distribution. Investigation of various reaction parameters showed that mild reaction conditions (ambient temperature and neutral pH), plus appropriate use of H2O2 and NaNO2 could prevent inactivation of HRP and polymerization of the substrates. Compared to aqueous-organic co-solvent reaction media, the aqueous-organic two-liquid phase system had great advantages in increasing the dissolved concentration of substrate and alleviating substrate inhibition. Analysis of the aromatic compounds' structural characteristics indicated that substrates containing substituents of NH2 or OH were readily catalyzed. Furthermore, analysis of the relationship between natural bond orbital (NBO) charges on carbon atoms in benzene ring, as calculated by the density functional method, and the nitro product distribution characteristics, demonstrated that the favored nitration sites were the ortho and para positions of substituents in benzene ring, similar to the selectivity of chemical nitration.

  1. Water encapsulation in a polyoxapolyaza macrobicyclic compound.

    Science.gov (United States)

    Mateus, Pedro; Delgado, Rita; Groves, Patrick; Campos, Sara R R; Baptista, António M; Brandão, Paula; Félix, Vítor

    2012-08-17

    A new heteroditopic macrobicyclic compound (t(2)pN(5)O(3)) containing two separate polyoxa and polyaza compartments was synthesized in good yield through a [1 + 1] "tripod-tripod coupling" strategy. The X-ray crystal structure of H(3)t(2)pN(5)O(3)(3+) revealed the presence of one encapsulated water molecule accepting two hydrogen bonds from two protonated secondary amines and donating a hydrogen bond to one amino group. The acid-base behavior of the compound was studied by potentiometry at 298.2 K in aqueous solution and at ionic strength 0.10 M in KCl. The results revealed unusual protonation behavior, namely a surprisingly low fourth protonation constant contrary to what was expected for the compound. (1)H NMR and DOSY experiments, as well as molecular modeling studies, showed that the water encapsulation and the conformation observed in the solid state are retained in solution. The strong binding of the encapsulated water molecule, reinforced by the cooperative occurrence of a trifurcated hydrogen bond at the polyether compartment of the macrobicycle, account for the very low log K(4)(H) value obtained.

  2. Raman Spectroscopy for Analysis of Thorium Compounds

    Energy Technology Data Exchange (ETDEWEB)

    Su, Yin-Fong; Johnson, Timothy J.; Olsen, Khris B.

    2016-05-12

    The thorium fuel cycle is an alternative to the uranium fuel cycle in that when 232Th is irradiated with neutrons it is converted to 233U, another fissile isotope. There are several chemical forms of thorium which are used in the Th fuel cycle. Recently, Raman spectroscopy has become a very portable and facile analytical technique useful for many applications, including e.g. determining the chemical composition of different materials such as for thorium compounds. The technique continues to improve with the development of ever-more sensitive instrumentation and better software. Using a laboratory Fourier-transform (FT)-Raman spectrometer with a 785 nm wavelength laser, we were able to obtain Raman spectra from a series of thorium-bearing compounds of unknown origin. These spectra were compared to the spectra of in-stock-laboratory thorium compounds including ThO2, ThF4, Th(CO3)2 and Th(C2O4)2. The unknown spectra showed very good agreement to the known standards, demonstrating the applicability of Raman spectroscopy for detection and identification of these nuclear materials.

  3. Antitumor activity of chemical modified natural compounds

    Directory of Open Access Journals (Sweden)

    Marilda Meirelles de Oliveira

    1991-01-01

    Full Text Available Search of new activity substances starting from chemotherapeutic agents, continously appears in international literature. Perhaps this search has been done more frequently in the field of anti-tumor chemotherapy on account of the unsuccess in saving advanced stage patients. The new point in this matter during the last decade was computer aid in planning more rational drugs. In near future "the accessibility of supercomputers and emergence of computer net systems, willopen new avenues to rational drug design" (Portoghese, P. S. J. Med. Chem. 1989, 32, 1. Unknown pharmacological active compounds synthetized by plants can be found even without this eletronic devices, as tradicional medicine has pointed out in many contries, and give rise to a new drug. These compounds used as found in nature or after chemical modifications have produced successful experimental medicaments as FAA, "flavone acetic acid" with good results as inibitors of slow growing animal tumors currently in preclinical evaluation for human treatment. In this lecture some international contributions in the field of chemical modified compounds as antineoplasic drugs will be examined, particularly those done by Brazilian researches.

  4. Heavy metal screening in compounds feeds

    Directory of Open Access Journals (Sweden)

    Tomas Toth

    2015-05-01

    Full Text Available Heavy metals are generally classified as basic groups of pollutants that are now a days found in different environmental compartments. This is quite a large group of contaminants, which have different characteristics, effects on the environment and sources of origin. For environment pose the greatest risks, especially heavy metals produced by anthropogenic activities that adversely affect the health and vitality of organisms and natural environmental conditions. Livestock nutrition is among the main factors which affect not only the deficiency of livestock production and quality of food of animal origin, but they are also a factor affecting the safety and wholesomeness and the animal health. Compound feeds is characterized as a mixture of two or more feed grain. Containing organic, inorganic nutrients and specifically active compound feed meet the nutritional requirements of a given kind and age category of animals. They are used mainly in the diet of pigs, poultry, but also the nutrition of cattle, sheep, horses and other animal categories. The basic ingredients are cereals in proportion of 60-70 %. The aim of this thesis was to analyze the content of hazardous elements (copper, zinc, iron, manganese, cobalt, nickel, chromium, lead, cadmium, mercury in 15 samples of compound feeds and then evaluating their content in comparison with maximum limits laid down by Regulation of the Government of the Slovak Republic and Regulation Commission (EC.

  5. An introduction to the chemistry of complex compounds

    CERN Document Server

    Grinberg, Aleksander Abramovich; Trimble, R F

    1962-01-01

    An Introduction to the Chemistry of Complex Compounds discusses the fundamental concepts that are essential in understanding the underlying principles of complex compounds. The coverage of the book includes the compounds of the hexa, penta, and tetrammine type; compounds of the tri, dl, monoamine and hexacido types for the coordination number of 6; and complex compounds with a coordination number of 4. The text also covers the effects and chemical properties of complex compounds, such as the nature of the force of complex formation; the mutual effects of coordinated groups; and acid-base prope

  6. Compounding and variational morphology: the analysis of inflection in Spanish compounds

    Directory of Open Access Journals (Sweden)

    Cristina Buenafuentes

    2014-05-01

    Full Text Available This paper analyzes the morphological variation related to gender and number in Spanish compounding such as plural noun in [V+N]ncompounds (ellavaplatos, not el lavaplato; el cazamariposas, not *el cazamariposa, the gender and number asymmetries between the actual compound and its parts (cabezafem. + cuadradafem. à el cabeza cuadradamasc., relacionesfem. pl. + públicasfem. pl. à el relaciones públicasmasc. sing., the presence of inflectional markers inside compounds (sord-o-mudafem, not *sord-a-mudafem., and the variation that takes place in many plural compounds (casas cuartel or casas cuarteles ‘house quarter’, coches cama or coches camas ‘car and bed’. Basing ourselves on the classic model of level ordering with an admixture of Booij's distinction between inherent and contextual inflection, this piece of research proves that these cases of morphological variation can be approached as a morphological component, accessible to syntax. This model also relativizes the importance of the head in compounding and highlights the value of morphology, lexis and syntax interfaces.

  7. Antifungal and Antiaflatoxigenic Methylenedioxy-Containing Compounds and Piperine-Like Synthetic Compounds

    Directory of Open Access Journals (Sweden)

    Young-Sun Moon

    2016-08-01

    Full Text Available Twelve methylenedioxy-containing compounds including piperine and 10 piperine-like synthetic compounds were assessed to determine their antifungal and antiaflatoxigenic activities against Aspergillus flavus ATCC 22546 in terms of their structure–activity relationships. Piperonal and 1,3-benzodioxole had inhibitory effects against A. flavus mycelial growth and aflatoxin B1 production up to a concentration of 1000 μg/mL. Ten piperine-like synthetic compounds were synthesized that differed in terms of the carbon length in the hydrocarbon backbone and the presence of the methylenedioxy moiety. In particular, 1-(2-methylpiperidin-1-yl-3-phenylprop-2-en-1-one had potent antifungal and antiaflatoxigenic effects against A. flavus up to a concentration of 1 μg/mL. This synthetic compound was remarkable because the positive control thiabendazole had no inhibitory effect at this concentration. Reverse transcription-PCR analysis showed that five genes involved in aflatoxin biosynthesis pathways were down-regulated in A. flavus, i.e., aflD, aflK, aflQ, aflR, and aflS; therefore, the synthetic compound inhibited aflatoxin production by down-regulating these genes.

  8. Antifungal and Antiaflatoxigenic Methylenedioxy-Containing Compounds and Piperine-Like Synthetic Compounds

    Science.gov (United States)

    Moon, Young-Sun; Choi, Won-Sik; Park, Eun-Sil; Bae, In Kyung; Choi, Sung-Deuk; Paek, Ockjin; Kim, Sheen-Hee; Chun, Hyang Sook; Lee, Sung-Eun

    2016-01-01

    Twelve methylenedioxy-containing compounds including piperine and 10 piperine-like synthetic compounds were assessed to determine their antifungal and antiaflatoxigenic activities against Aspergillus flavus ATCC 22546 in terms of their structure–activity relationships. Piperonal and 1,3-benzodioxole had inhibitory effects against A. flavus mycelial growth and aflatoxin B1 production up to a concentration of 1000 μg/mL. Ten piperine-like synthetic compounds were synthesized that differed in terms of the carbon length in the hydrocarbon backbone and the presence of the methylenedioxy moiety. In particular, 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one had potent antifungal and antiaflatoxigenic effects against A. flavus up to a concentration of 1 μg/mL. This synthetic compound was remarkable because the positive control thiabendazole had no inhibitory effect at this concentration. Reverse transcription-PCR analysis showed that five genes involved in aflatoxin biosynthesis pathways were down-regulated in A. flavus, i.e., aflD, aflK, aflQ, aflR, and aflS; therefore, the synthetic compound inhibited aflatoxin production by down-regulating these genes. PMID:27537912

  9. The Atmospheric Fate of Organic Nitrogen Compounds

    Science.gov (United States)

    Borduas, Nadine

    Organic nitrogen compounds are present in our atmosphere from biogenic and anthropogenic sources and have impacts on air quality and climate. Due to recent advances in instrumentation, these compounds are being detected in the gas and particle phases, raising questions as to their source, processing and sinks in the environment. With their recently identified role as contributors to aerosol formation and growth, their novel large scale use as solvents in carbon capture and storage (CCS) technology and their emissions from cigarette smoke, it is now important to address the gaps in our understanding of the fate of organic nitrogen. Experimentally and theoretically, I studied the chemical atmospheric fate of specific organic nitrogen compounds in the amine, amide and isocyanate families, yielding information that can be used in chemical transport models to assess the fate of this emerging class of atmospheric molecules. I performed kinetic laboratory studies in a smog chamber to measure the room temperature rate coefficient for reaction with the hydroxyl radical of monoethanolamine, nicotine, and five different amides. I employed online-mass spectrometry techniques to quantify the oxidation products. I found that amines react quickly with OH radicals with lifetimes of a few hours under sunlit conditions, producing amides as oxidation products. My studies on amides revealed that they have much longer lifetimes in the atmosphere, ranging from a few hours to a week. Photo-oxidation of amides produces isocyanates and I investigated these mechanisms in detail using ab initio calculations. Furthermore, I experimentally measured isocyanic acid's Henry's Law constant as well as its hydrolysis rate constants to better understand its sinks in the atmosphere. Finally, I re-examined the structure-activity relationship (SAR) of organic nitrogen molecules for improved model parameterizations.

  10. ( x = 0-0.3) Compounds

    Science.gov (United States)

    Maji, Binoy Kumar; Jena, Hrudananda; Govindan Kutty, K. V.

    2014-09-01

    Various compositions of Sr1- x La x MoO4+δ ( x = 0.05, 0.1, 0.2, and 0.3) compounds were prepared by solid state reaction route. The samples were characterized by powder-XRD, TG-DTA, and SEM-EDAX techniques. Formation of single crystalline phases of Sr1- x La x MoO4+δ was confirmed from powder-XRD patterns. The thermal stability of La-doped SrMoO4 compounds was investigated by TG-DTA. Uniform grain distribution was observed in the SEM image of 10-20 mol.% La-substituted compositions. Needle-shaped structures were observed in the SEM image of Sr0.3La0.1MoO4+δ and were confirmed to be La2Mo2O9 by XRD examination. The electrical conductivity of these compounds was measured by AC-impedance technique in the temperature range of 373-1073 K in air ambience and compared with that of pristine SrMoO4. The electrical conductivity was found to decrease for La-substituted SrMoO4 compared to pristine SrMoO4. The diffusion coefficient calculated from the electrical conductivity was found to be in the range of 1.94 ± 0.02 × 10-13 to 1.15 ± 0.01 × 10-11 cm2/S at 873-1173 K for substituted composition and 3.47 ± 0.02 × 10-13 to 2.48 ± 0.01 × 10-10 cm2/S for pristine SrMoO4 at 673-1073 K temperature range.

  11. Preparation of some compounded soup powders

    Directory of Open Access Journals (Sweden)

    B. S. Bhatia

    1961-01-01

    Full Text Available Recipes for the preparation of some compounded soup powders from tomatoes, potatoes, carrots, green peas, dried peas, chicken and mutton using components like corn starch, skim milk powder, hydrogenated groundnut oil, common salt, mixed spices (black pepper, caraway and ginger and monosodium glutamate have been developed. Pretreatment and drying conditions for the preparation of pre-cooked dry bases from tomatoes, potatoes, carrots, green peas, dried peas, chicken and mutton have been determined. Except for tomatoes where vacuum drier is necessary, other bases can be easily prepared in a simple cross flow hot air cabinet drier and used subsequently in the preparation of soup powders.

  12. Compound odontoma associated with impacted maxillary incisors

    Directory of Open Access Journals (Sweden)

    S Sreedharan

    2012-01-01

    Full Text Available Odontomas are considered to be the most common odontogenic tumors of the oral cavity. Some authors consider it as malformations rather than true neoplasms. The exact etiology of odontomes is still not known. Most odontomes are asymptomatic and are discovered during routine radiographic investigations. Odontomes generally cause disturbances in the eruption of the teeth, most commonly delayed eruption or deflection. The present report describes the surgical management of a case of compound odontoma in a 10-year-old boy who presented with a complaint of swelling in the maxillary right anterior region and retained deciduous incisors. The related literature is also being reviewed in this article.

  13. Compound odontoma associated with impacted maxillary incisors.

    Science.gov (United States)

    Sreedharan, S; Krishnan, I S

    2012-01-01

    Odontomas are considered to be the most common odontogenic tumors of the oral cavity. Some authors consider it as malformations rather than true neoplasms. The exact etiology of odontomes is still not known. Most odontomes are asymptomatic and are discovered during routine radiographic investigations. Odontomes generally cause disturbances in the eruption of the teeth, most commonly delayed eruption or deflection. The present report describes the surgical management of a case of compound odontoma in a 10-year-old boy who presented with a complaint of swelling in the maxillary right anterior region and retained deciduous incisors. The related literature is also being reviewed in this article.

  14. Palliative care and compound in household pets.

    Science.gov (United States)

    Gaskins, Jessica L

    2012-01-01

    Palliative care is not a term solely used for humans when discussing health care; the term is also used when discussing veterinary patients. Pets are considered part of the family by pet owners, and they have a special relationship that only another pet owner can fully understand. This article discusses some of the healthcare problems that affect pets (and their owners), statistics on the most commonly used medications for veterinary patients, quality of life, and discussions on the veterinary pharmacist-owner-palliative pet relationship and how compounding pharmacists can prepare patient-specific medications.

  15. Penta-coordinate phosphorous compounds and biochemistry

    Institute of Scientific and Technical Information of China (English)

    林长学; 李艳梅; 成昌梅; 韩波; 万荣; 冯亚兵; 赵玉芬

    2002-01-01

    The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleoside-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipeptide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

  16. Multicutter machining of compound parametric surfaces

    Science.gov (United States)

    Hatna, Abdelmadjid; Grieve, R. J.; Broomhead, P.

    2000-10-01

    Parametric free forms are used in industries as disparate as footwear, toys, sporting goods, ceramics, digital content creation, and conceptual design. Optimizing tool path patterns and minimizing the total machining time is a primordial issue in numerically controlled (NC) machining of free form surfaces. We demonstrate in the present work that multi-cutter machining can achieve as much as 60% reduction in total machining time for compound sculptured surfaces. The given approach is based upon the pre-processing as opposed to the usual post-processing of surfaces for the detection and removal of interference followed by precise tracking of unmachined areas.

  17. Metabolism of aromatic compounds by Caulobacter crescentus

    Energy Technology Data Exchange (ETDEWEB)

    Chatterjee, D.K.; Bourquin, A.W.

    1987-05-01

    Cultures of Caulobacter crescentus were found to grow on a variety of aromatic compounds. Degradation of benzoate, p-hydroxybenzoate, and phenol was found to occur via ..beta..-ketoadipate. The induction of degradative enzymes such as benzoate 1,2-dioxygenase, the ring cleavage enzyme catechol 1,2-dioxygenase, and cis,cis-muconate lactonizing enzyme appeared similar to the control mechanism present in Pseudomonas spp. Both benzoate 1,2-dioxygenase and catechol 1,2-dioxygenase had stringent specificities, as revealed by their action toward substituted benzoates and substituted catechols, respectively.

  18. Study on austenitic nitrocarburizing without compound layer

    Energy Technology Data Exchange (ETDEWEB)

    Yang, X. [Univ. of Petroleum, Dongying, Shandong (China); Kong, C.; Qiao, Y. [Shandong Polytechnic Univ., Jinan, Shandong (China)

    1995-12-31

    This paper presents an advanced austenitic nitrocarburizing process. Medium-carbon steel was used in austenitic nitrocarburizing with methanol/ammonia atmospheres. A particular hardened case without compound layer was obtained at 680 C processing temperature and a moderate nitrogen potential level and for steel 45 nitrocarburized, there is a fine-grain region beneath the austenite case. The forming and developing mechanism of the fine-grain region was analyzed and the microhardness profiles of the layer before and after ageing were determined. Having the advantages of shorter processing time and a superior hardened case, this treatment is expected to supersede the conventional ferritic nitrocarburizing process in many wear resistance applications.

  19. Compound droplet manipulations on fiber arrays

    CERN Document Server

    Weyer, Floriane; Dreesen, Laurent; Vandewalle, Nicolas

    2015-01-01

    Recent works demonstrated that fiber arrays may constitue the basis of an open digital microfluidics. Various processes, such as droplet motion, fragmentation, trapping, release, mixing and encapsulation, may be achieved on fiber arrays. However, handling a large number of tiny droplets resulting from the mixing of several liquid components is still a challenge for developing microreactors, smart sensors or microemulsifying drugs. Here, we show that the manipulation of tiny droplets onto fiber networks allows for creating compound droplets with a high complexity level. Moreover, this cost-effective and flexible method may also be implemented with optical fibers in order to develop fluorescence-based biosensor.

  20. Spin and orbital moments in actinide compounds

    DEFF Research Database (Denmark)

    Lebech, B.; Wulff, M.; Lander, G.H.

    1991-01-01

    experiments designed to determine the magnetic moments at the actinide and transition-metal sublattice sites in compounds such as UFe2, NpCo2, and PuFe2 and to separate the spin and orbital components at the actinide sites. The results show, indeed, that the ratio of the orbital to spin moment is reduced......The extended spatial distribution of both the transition-metal 3d electrons and the actinide 5f electrons results in a strong interaction between these electron states when the relevant elements are alloyed. A particular interesting feature of this hybridization, which is predicted by single...

  1. Averaging of Backscatter Intensities in Compounds

    Science.gov (United States)

    Donovan, John J.; Pingitore, Nicholas E.; Westphal, Andrew J.

    2002-01-01

    Low uncertainty measurements on pure element stable isotope pairs demonstrate that mass has no influence on the backscattering of electrons at typical electron microprobe energies. The traditional prediction of average backscatter intensities in compounds using elemental mass fractions is improperly grounded in mass and thus has no physical basis. We propose an alternative model to mass fraction averaging, based of the number of electrons or protons, termed “electron fraction,” which predicts backscatter yield better than mass fraction averaging. PMID:27446752

  2. Reduction of Compound Lotteries with Objective Probabilities

    DEFF Research Database (Denmark)

    Harrison, Glenn W.; Martínez-Correa, Jimmy; Swarthout, J. Todd

    2015-01-01

    -stages compound lotteries, and their actuarially equivalent one-stage lotteries. We find violations of ROCL and that behavior is better characterized by a source-dependent version of the Rank-Dependent Utility model rather than Expected Utility Theory. Since we use the popular “1-in-K” random lottery incentive....... These results are supported by both structural estimation of latent preferences as well as non-parametric analysis of choice patterns. The random lottery incentive mechanism, used as payment protocol, itself induces an additional layer of “compounding” by design that might create confounds in tests of ROCL...

  3. Dietary phenolic compounds and vitamin e bioavailability

    OpenAIRE

    2004-01-01

    The human diet contains a vast number of dietary phenolic compounds of which vitamin E represents only one class. Vitamin E is a generic name for all substances exerting the biological functions of α-tocopherol. The two quantitatively most important E vitamers are α- and γ-tocopherol (α-T and γ-T). The fat soluble vitamin E is absorbed and transported in the circulation to the liver where α-T is preferentially re-secreted into the bloodstream while the other vitamers are degraded by cytochrom...

  4. Atmospheric lifetimes of selected fluorinated ether compounds

    DEFF Research Database (Denmark)

    Heathfield, A.E.; Anastasi, C.; Pagsberg, Palle Bjørn;

    1998-01-01

    Atmospheric lifetimes have been estimated for a selection of ethers, the latter representing a class of compounds being considered as replacements for chlorofluorocarbons. The estimates are based on laboratory measurements of rate constants for the reaction of the OH radical with the ethers......, and a comparison with the behaviour of methyl chloroform in the atmosphere. The lifetimes for the ethers ranged from a few hours to half a year, significantly lower than those of chlorofluorocarbons and other replacements being considered. (C) 1998 Elsevier Science Ltd. All rights reserved....

  5. Penta-coordinate phosphorous compounds and biochemistry

    Institute of Scientific and Technical Information of China (English)

    林长学; 韩波; 赵玉芬; 万荣; 李艳梅; 冯亚兵; 成昌梅

    2002-01-01

    The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

  6. Bioactive compounds in berries relevant to human health

    NARCIS (Netherlands)

    Battino, M.; Beekwilder, M.J.; Denoyes-Rothan, B.; Laimer, M.

    2009-01-01

    Berries contain powerful antioxidants, potential allergens, and other bioactive compounds. Genetic and environmental factors affect production and storage of such compounds. For this reason breeding and biotechnological approaches are currently used to control or to increase the content of specific

  7. Palladium catalyzed hydrogenation of bio-oils and organic compounds

    Science.gov (United States)

    Elliott, Douglas C.; Hu, Jianli; Hart, Todd R.; Neuenschwander, Gary G.

    2008-09-16

    The invention provides palladium-catalyzed hydrogenations of bio-oils and certain organic compounds. Experimental results have shown unexpected and superior results for palladium-catalyzed hydrogenations of organic compounds typically found in bio-oils.

  8. Neoclassical compounds and final combining forms in English

    Directory of Open Access Journals (Sweden)

    Ana Díaz-Negrillo

    2014-12-01

    Full Text Available English neoclassical compounds rely on a distinct vocabulary stock and present morphological features which raise a number of theoretical questions. Generalisations about neoclassical compounds are also problematic because the output is by no means homogeneous, that is, defining features of neoclassical compounds sometimes co-exist with features that are not prototypical of these formations. The paper looks at neoclassical compounds with a view to exploring patterns of morphological behaviour and development in this class of compounds. The approach is both synchronic and diachronic: it researches whether the morphological behaviour of recently formed compounds is different from that of earlier compounds and, if so, in which respects. This is assessed on data from the BNC with respect to some of the features that are cited in the literature as defining properties of neoclassical compounds, specifically, their internal configuration, the occurrence or not of a linking vowel, and their productivity.

  9. Experimental and theoretical studies of manganite and magnetite compounds Transition oxide compounds

    CERN Document Server

    Srinitiwarawong, C

    2002-01-01

    In the recent years interest in the transition oxide compounds has renewed among researchers in the field of condensed matter physics. This thesis presents the studies of the two families of the transition oxides, the manganite and magnetite compounds. Manganite has regained the interest since the discovery of the large magnetoresistance around its Curie temperature in 1990s. Magnetite on the other hand is the oldest magnetic material known to man however some of its physical properties are still controversial. The experimental works address some basic properties of these compounds when fabricated in the form of thin films. These include the resistivity measurements and magnetic measurements as well as the Hall effect. The various models of transport mechanism have been compared. The magnetic field and the temperature dependence of magnetoresistance have also been studied. Simple devices such as an artificial grain boundary and bilayers thin film have been investigated. The second part of this thesis concentr...

  10. Induction of endogenous murine retrovirus by hydroxyurea and related compounds

    Energy Technology Data Exchange (ETDEWEB)

    Rascati, R.J.; Tennant, R.W.

    1978-06-01

    Hydroxyurea and two related compounds, carbamoyloxyurea and formamidoxime, induce endogenous retrovirus expression in AKR mouse embryo cells. Only the induction of ecotropic (N-tropic).virus was detected. The ability of each compound to induce shows a linear dose-response over a limited range of concentrations which correlate with the cytotoxicity of each of the compounds. The data suggest that these compounds may induce virus expression via damage to cellular DNA.

  11. Synthesis and characterization of heterocyclic substituted fluoran compounds

    Directory of Open Access Journals (Sweden)

    SACHIN V. PATEL

    2007-11-01

    Full Text Available New quinazolinone-substituted fluoran compounds were synthesized by reaction of keto acid, 2’-carboxy-2-hydroxy-4-N-pyrrolidinylbenzophenone with different quinazolinone derivatives in the presence of conc. sulphuric acid. All the synthesized fluoran compounds were characterized by spectroscopic methods (IR, 1H-NMR and UV–visible spectroscopy and elemental analysis. The fluoran compounds are colourless or nearly colourless and develop colour on contact with electron-accepting compounds.

  12. Filaggrin compound heterozygous patients carry mutations in trans position

    DEFF Research Database (Denmark)

    Carlsen, Berit C; Meldgaard, Michael; Johansen, Jeanne D;

    2013-01-01

    More than 40 null mutations in the filaggrin (FLG) gene are described. It is therefore possible to find two different null mutations in one individual (compound heterozygosity). It has been generally perceived that homozygous and compound heterozygous individuals were genotypically comparable; ho...... compound heterozygous individuals were found to carry the two mutations in trans position. FLG null mutation compound heterozygous individuals can be considered functionally equivalent to FLG null mutation homozygosity for any of the two mutations....

  13. Synthesis,Characterization and Biological Activities of Novel Acrylamide Compounds

    Institute of Scientific and Technical Information of China (English)

    XU Liang-zhong; XU Zhong-jie; ZHANG Gong-sheng; ZHOU Kai; ZHAI Zhi-wei

    2008-01-01

    With dimethomorph and flumorph as the leading compounds,four novel acrylamide compounds with two types of structure were designed and synthesized by means of the method of"me too chemistry".The target compounds were characterized by 1H NMR,IR,MS,and elemental analysis.The influences of solvent and raw material on the yield were investigated and optimum processing conditions were determined.The results of preliminary biological tests show that all those compounds exhibit certain antifungal activities.

  14. Human biological monitoring of suspected endocrine-disrupting compounds.

    Science.gov (United States)

    Faniband, Moosa; Lindh, Christian H; Jönsson, Bo A G

    2014-01-01

    Endocrine-disrupting compounds are exogenous agents that interfere with the natural hormones of the body. Human biological monitoring is a powerful method for monitoring exposure to endocrine disrupting compounds. In this review, we describe human biological monitoring systems for different groups of endocrine disrupting compounds, polychlorinated biphenyls, brominated flame retardants, phthalates, alkylphenols, pesticides, metals, perfluronated compounds, parabens, ultraviolet filters, and organic solvents. The aspects discussed are origin to exposure, metabolism, matrices to analyse, analytical determination methods, determinants, and time trends.

  15. Basics of compounding: basics of compounding with aliquots, dilutions, and concentrates.

    Science.gov (United States)

    Allen, Loyd V

    2010-01-01

    Pharmacists involved in Compounding must consider a number of factors when determining the actual quantity of an active ingredient to use for a compounded prescription. Many drug substances and excipients are available as aliquots, dilutions, and concentrates and do not consist of 100% drug or chemical. Since the bulk substance, or active pharmaceutical ingredient or excipient is not 100% active drug in all cases, then it is important to know the strength of the item so that appropriate allowances can be made to obtain the correct amount.

  16. Recent changes in anthropogenic reactive nitrogen compounds

    Science.gov (United States)

    Andronache, Constantin

    2014-05-01

    Significant anthropogenic perturbations of the nitrogen cycle are the result of rapid population growth, with mounting need for food and energy production. The increase of reactive nitrogen compounds (such as NOx, HNO3, NH3, and N2O) has a significant impact on human health, environment, and climate. NOx emissions contribute to O3 chemistry, aerosol formation and acidic precipitation. Ammonia is a notable atmospheric pollutant that may deteriorate ecosystems and contribute to respiratory problems. It reacts with acidic gases to form aerosols or is deposited back to ecosystems. The application of fertilizers accounts for most of the N2O production, adding to greenhouse gas emissions. We analyze the change of some reactive nitrogen compounds based on observations, in eastern United States. Results show that the control of NOx and SO2 emissions over the last decades caused a significant decrease of acidic deposition. The nitrate deposition is highest in eastern US, while the ammonium ion concentration is highest in central US regions. Overall, the inorganic nitrogen wet deposition from nitrate and ammonium is enhanced in central, and eastern US. Research shows that sensitive ecosystems in northeastern regions exhibit a slow recovery from the accumulated effects of acidic deposition. Given the growing demand for nitrogen in agriculture and industry, we discuss possible pathways to reduce the impact of excess reactive nitrogen on the environment.

  17. [Pharmacy compounding of medicinal shampoos: an update].

    Science.gov (United States)

    Varçin, M; Vandael, A; Zier-Vercammen, J

    2012-12-01

    Delivery of magistral (extemporaneous) preparations must comply with quality standards, as described in the "Guide to Good Officinal Pharmaceutical Practice" and the pharmacy's Quality Manual (Royal Decree of 21 January 2009). In this study, the shampoo Simplex Herdewijn, prepared with Texapon NSO, is compared with commercially available basic shampoos (Shampoo Fagron and Shampoo Simplex Conforma) with respect to its composition as well as its physicochemical properties. These basic shampoos were used to develop medicinal shampoos. The active compounds of these shampoos were: 0.5% hexachlorophene, 1% ichtammol, 1% cade oil or 2% liquor carbonis detergens. The necessary concentration of Cetomacrogol 1000, required to solubilise the active compounds was determined, as well as the amount of sodium chloride needed to adjust the viscosity of the shampoo. The viscosity of the basic and medicinal shampoos was determined by means of rheograms and by calculating their apparent viscosity. Additionally, a number of fundamental aspects of the formulation of shampoos are discussed in this paper. The results can be useful to pharmacists as guidelines for the preparation of medicinal shampoos. Beside patient instruction and pharmaceutical care, the intrinsic quality of magistral preparations is a prerequisite for therapeutic activity.

  18. Carcinogenic compounds in alcoholic beverages: an update.

    Science.gov (United States)

    Pflaum, Tabea; Hausler, Thomas; Baumung, Claudia; Ackermann, Svenja; Kuballa, Thomas; Rehm, Jürgen; Lachenmeier, Dirk W

    2016-10-01

    The consumption of alcoholic beverages has been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC) since 1988. More recently, in 2010, ethanol as the major constituent of alcoholic beverages and its metabolite acetaldehyde were also classified as carcinogenic to humans. Alcoholic beverages as multi-component mixtures may additionally contain further known or suspected human carcinogens as constituent or contaminant. This review will discuss the occurrence and toxicology of eighteen carcinogenic compounds (acetaldehyde, acrylamide, aflatoxins, arsenic, benzene, cadmium, ethanol, ethyl carbamate, formaldehyde, furan, glyphosate, lead, 3-MCPD, 4-methylimidazole, N-nitrosodimethylamine, pulegone, ochratoxin A, safrole) occurring in alcoholic beverages as identified based on monograph reviews by the IARC. For most of the compounds of alcoholic beverages, quantitative risk assessment provided evidence for only a very low risk (such as margins of exposure above 10,000). The highest risk was found for ethanol, which may reach exposures in ranges known to increase the cancer risk even at moderate drinking (margin of exposure around 1). Other constituents that could pose a risk to the drinker were inorganic lead, arsenic, acetaldehyde, cadmium and ethyl carbamate, for most of which mitigation by good manufacturing practices is possible. Nevertheless, due to the major effect of ethanol, the cancer burden due to alcohol consumption can only be reduced by reducing alcohol consumption in general or by lowering the alcoholic strength of beverages.

  19. [Preparations and biological properties of chiral compounds].

    Science.gov (United States)

    Sinko, Goran

    2005-12-01

    Enantiomers of chiral compounds may express various biological activities and also different toxicities. Examples of different pharmacological effects of some chiral drugs such as fluoxetine, penicillamine, ibuprofen and albuterol are provided in this paper. Due to possible differences in activity, the chiral drugs are required to be pure enantiomeric compounds in order to be more effective and safer to use. In the laboratory, enantiomers are mainly synthesized as racemates (an equimolar mixture of enantiomers) while in biological pathways only one enantiomeric form is produced, such as amino acids, sugars and lipids. This paper presents the principles of chirality, general information about enantiomers and their biological aspects. It gives an outline of stereoselective methods for chromatographic resolution of enantiomers with stereoselective protein stationary phases, i.e. capillary electrochromatography (CEC) and high performance liquid chromatography (HPLC). The use of enzyme biotransformations (hydrolysis, oxidation and reduction) in chiral syntheses of carboxyl-, phosphoryl- or beta-hydroxy esters, alcohols, epoxides and cis-carboxyl sulphoxide is described. This article also includes an example of lipase stereoselectivity improvement by amino acid mutations within the enzyme active site.

  20. Thermoelectric transport in rare-earth compounds

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, Ulrike

    2007-07-01

    This work focuses on the thermoelectric transport in rare-earth compounds. The measurements of the thermal conductivity, thermopower, and Nernst coefficient are supplemented by investigations of other quantities as magnetic susceptibility and specific heat. Chapter 2 provides an introduction to the relevant physical concepts. Section 1 of that chapter summarizes the characteristic properties of rare-earth systems; section 2 gives an overview on thermoelectric transport processes in magnetic fields. The applied experimental techniques as well as the new experimental setup are described in detail in Chapter 3. The experimental results are presented in Chapter 4-6, of which each concentrates on a different subject. In Chapter 4, various Eu clathrates and the skutterudite-like Ce{sub 3}Rh{sub 4}Sn{sub 13} are presented, which have been investigated as potential thermoelectric materials for applications. Chapter 5 focusses on the study of the energy scales in the heavy-fermion series Lu{sub 1-x}Yb{sub x}Rh{sub 2}Si{sub 2} and Ce{sub x}La{sub 1-x}Ni{sub 2}Ge{sub 2} by means of thermopower investigations. Chapter 6 is dedicated to the thermoelectric transport properties of the correlated semimetal CeNiSn with special emphasis on the Nernst coefficient of this compound. (orig.)

  1. Polyphenol Compound as a Transcription Factor Inhibitor

    Directory of Open Access Journals (Sweden)

    Seyeon Park

    2015-10-01

    Full Text Available A target-based approach has been used to develop novel drugs in many therapeutic fields. In the final stage of intracellular signaling, transcription factor–DNA interactions are central to most biological processes and therefore represent a large and important class of targets for human therapeutics. Thus, we focused on the idea that the disruption of protein dimers and cognate DNA complexes could impair the transcriptional activation and cell transformation regulated by these proteins. Historically, natural products have been regarded as providing the primary leading compounds capable of modulating protein–protein or protein-DNA interactions. Although their mechanism of action is not fully defined, polyphenols including flavonoids were found to act mostly as site-directed small molecule inhibitors on signaling. There are many reports in the literature of screening initiatives suggesting improved drugs that can modulate the transcription factor interactions responsible for disease. In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1, c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB and β-catenin/T cell factor (Tcf.

  2. Main antimicrobial compounds in table olives.

    Science.gov (United States)

    Medina, Eduardo; Brenes, Manuel; Romero, Concepción; García, Aranzazu; de Castro, Antonio

    2007-11-28

    The inhibitors involved in the lactic acid fermentation of table olives were investigated in aseptic olive brines of the Manzanilla and Gordal varieties. Phenolic and oleosidic compounds in these brines were identified by high-performance liquid chromatography with ultraviolet and electrospray ionization mass spectrometry detection, and several substances were also characterized by nuclear magnetic resonance. Among these compounds, the dialdehydic form of decarboxymethyl elenolic acid linked to hydroxytyrosol showed the strongest antilactic acid bacteria activity, and its presence in brines could explain the growth inhibition of these microorganisms during olive fermentation. However, it was found that the dialdehydic form of decarboxymethyl elenolic acid, identified for the first time in table olives, and an isomer of oleoside 11-methyl ester were also effective against Lactobacillus pentosus and can, therefore, contribute to the antimicrobial activity of olive brines. It must also be stressed that the three new inhibitors discovered in table olive brines exerted a more potent antibacterial activity than the well-studied oleuropein and hydroxytyrosol.

  3. Alternative Forms of Compound Fractional Poisson Processes

    Directory of Open Access Journals (Sweden)

    Luisa Beghin

    2012-01-01

    Full Text Available We study here different fractional versions of the compound Poisson process. The fractionality is introduced in the counting process representing the number of jumps as well as in the density of the jumps themselves. The corresponding distributions are obtained explicitly and proved to be solution of fractional equations of order less than one. Only in the final case treated in this paper, where the number of jumps is given by the fractional-difference Poisson process defined in Orsingher and Polito (2012, we have a fractional driving equation, with respect to the time argument, with order greater than one. Moreover, in this case, the compound Poisson process is Markovian and this is also true for the corresponding limiting process. All the processes considered here are proved to be compositions of continuous time random walks with stable processes (or inverse stable subordinators. These subordinating relationships hold, not only in the limit, but also in the finite domain. In some cases the densities satisfy master equations which are the fractional analogues of the well-known Kolmogorov one.

  4. Compound cycle engine for helicopter application

    Science.gov (United States)

    Castor, Jere; Martin, John; Bradley, Curtiss

    1987-01-01

    The compound cycle engine (CCE) is a highly turbocharged, power-compounded, ultra-high-power-density, lightweight diesel engine. The turbomachinery is similar to a moderate-pressure-ratio, free-power-turbine gas turbine engine and the diesel core is high speed and a low compression ratio. This engine is considered a potential candidate for future military helicopter applications. Cycle thermodynamic specific fuel consumption (SFC) and engine weight analyses performed to establish general engine operating parameters and configurations are presented. An extensive performance and weight analysis based on a typical 2-hour helicopter (+30 minute reserve) mission determined final conceptual engine design. With this mission, CCE performance was compared to that of a contemporary gas turbine engine. The CCE had a 31 percent lower-fuel consumption and resulted in a 16 percent reduction in engine plus fuel and fuel tank weight. Design SFC of the CCE is 0.33 lb/hp-hr and installed wet weight is 0.43 lb/hp. The major technology development areas required for the CCE are identified and briefly discussed.

  5. Perspectives of antimony compounds in oncology

    Institute of Scientific and Technical Information of China (English)

    Pankaj SHARMA; Diego PEREZ; Armando CABRERA; Nee ROSAS; Jose Luis ARIAS

    2008-01-01

    Antimony, a natural element that has been used as a drug for over more than 100 years, has remarkable therapeutic efficacy in patients with acute promyelocytic leukemia. This review focuses on recent advances in developing antimony anti- cancer agents with an emphasis on antimony coordination complexes, Sb (Ⅲ) and Sb (V). These complexes, which include many organometallic complexes, may provide a broader spectrum of antitumoral activity. They were compared with classical platinum anticancer drugs. The review covers the literature data pub- lished up to 2007. A number of antimonials with different antitumoral activities are known and have diverse applications, even though little research has been done on their possibilities. It might be feasible to develop more specific and effective inhibitors for phosphatase-targeted, anticancer therapeutics through the screen- ing of sodium stibogluconate (SSG) and potassium antimonyltartrate-related compounds, which are comprised of antimony conjugated to different organic moieties. For example, SSG appears to be a better inhibitor than suramin which is a compound known for its antineoplastic activity against several types of cancers.

  6. Efficient synthesis of benzothiazine and acrylamide compounds

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Ana Maria Alves; Walfrido, Simone Torres Padua; Leite, Lucia Fernanda Costa; Lima, Maria Carmo Alves; Galdino, Suely Lins; Pitta, Ivan Rocha [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Antibioticos; Barbosa Filho, Jose Maria [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil); Simone, Carlos Alberto de; Ellena, Javier Alcides, E-mail: irpitta@gmail.co [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Inst. de Fisica

    2010-07-01

    This article describes the synthesis of the new (2Z)-2-(4-methoxybenzylidene)-6-nitro-4H -benzo[1,4]thiazine-3-one, (2Z)-2-(4-methoxybenzylidene)-4-methyl-6-nitro-4H-benzo[1,4]thiazine-3-one, (2Z)-6-amino-2-(4-methoxybenzylidene)-4H -benzo[1,4]thiazine-3-one, (2Z)-6-butylamino-2-(4-methoxybenzylidene)-4-methyl-4H-benzo[1,4] -thiazine-3-one and (2E)-N-alkyl-N-(2-hydroxy-5-nitrophenyl) -3-phenylacrylamides and the spectroscopic data. The arylidenebenzothiazine compounds were prepared using the Knoevenagel condensation with substituted benzaldehydes in the presence of sodium methoxide in DMF. The presence of a nitro substituent in the 4-position, water and a slightly acid reaction medium in this condensation caused the rupture of the benzothiazine ring and subsequent formation of the phenylacrylamide compounds. A crystallographic data was presented for (2E)-3-(4-bromophenyl)-N-dodecyl-N -(2-hydroxy-5-nitrophenyl) acrylamide. (author)

  7. Fungal Laccases Degradation of Endocrine Disrupting Compounds

    Directory of Open Access Journals (Sweden)

    Gemma Macellaro

    2014-01-01

    Full Text Available Over the past decades, water pollution by trace organic compounds (ng/L has become one of the key environmental issues in developed countries. This is the case of the emerging contaminants called endocrine disrupting compounds (EDCs. EDCs are a new class of environmental pollutants able to mimic or antagonize the effects of endogenous hormones, and are recently drawing scientific and public attention. Their widespread presence in the environment solicits the need of their removal from the contaminated sites. One promising approach to face this challenge consists in the use of enzymatic systems able to react with these molecules. Among the possible enzymes, oxidative enzymes are attracting increasing attention because of their versatility, the possibility to produce them on large scale, and to modify their properties. In this study five different EDCs were treated with four different fungal laccases, also in the presence of both synthetic and natural mediators. Mediators significantly increased the efficiency of the enzymatic treatment, promoting the degradation of substrates recalcitrant to laccase oxidation. The laccase showing the best performances was chosen to further investigate its oxidative capabilities against micropollutant mixtures. Improvement of enzyme performances in nonylphenol degradation rate was achieved through immobilization on glass beads.

  8. Acoustic transmission through compound subwavelength slit arrays

    Science.gov (United States)

    Ward, G. P.; Hibbins, A. P.; Sambles, J. R.; Smith, J. D.

    2016-07-01

    The angular dependence of the transmission of sound in air through four types of two-dimensional slit arrays formed of aluminium slats is explored, both experimentally and numerically. For a simple, subwavelength periodic slit array, it is well known that Fabry-Perot-like waveguide resonances, supported by the slit cavities, coupled to diffracted evanescent waves, result in enhanced acoustic transmission at frequencies determined by the length, width, and separation of each slit cavity. We demonstrate that altering the spacing or width of some of the slits to form a compound array (i.e., an array having a basis comprised of more than one slit) results in sharp dips in the transmission spectra, which may have a strong angular dependence. These features correspond to phase resonances, which have been studied extensively in the electromagnetic case. This geometry allows for additional near-field configurations compared to the simple array, whereby the field in adjacent cavities can be out of phase. Several types of compound slit arrays are investigated; one such structure is optimized to minimize the effect of boundary-layer loss mechanisms present in each slit cavity, thereby achieving a deep, sharp transmission minimum in a broad maximum.

  9. Compound Refractive Lenses for Thermal Neutron Applications

    Energy Technology Data Exchange (ETDEWEB)

    Gary, Charles K.

    2013-11-12

    This project designed and built compound refractive lenses (CRLs) that are able to focus, collimate and image using thermal neutrons. Neutrons are difficult to manipulate compared to visible light or even x rays; however, CRLs can provide a powerful tool for focusing, collimating and imaging neutrons. Previous neutron CRLs were limited to long focal lengths, small fields of view and poor resolution due to the materials available and manufacturing techniques. By demonstrating a fabrication method that can produce accurate, small features, we have already dramatically improved the focal length of thermal neutron CRLs, and the manufacture of Fresnel lens CRLs that greatly increases the collection area, and thus efficiency, of neutron CRLs. Unlike a single lens, a compound lens is a row of N lenslets that combine to produce an N-fold increase in the refraction of neutrons. While CRLs can be made from a variety of materials, we have chosen to mold Teflon lenses. Teflon has excellent neutron refraction, yet can be molded into nearly arbitrary shapes. We designed, fabricated and tested Teflon CRLs for neutrons. We demonstrated imaging at wavelengths as short as 1.26 ? with large fields of view and achieved resolution finer than 250 μm which is better than has been previously shown. We have also determined designs for Fresnel CRLs that will greatly improve performance.

  10. Pharmacology of selenium-containing compound

    Energy Technology Data Exchange (ETDEWEB)

    Abdullaev, R.A.; Gusenov, D.Ya.; Babakhanov, R.A.; Mirzoev, Kh.M.

    1985-09-01

    Selenium-containing compounds are used in increasing frequency in medicine; they affect biological indices of the human body showing anti-histamine and antioxidative activity; they can cause acute intoxication, promote tumor development in liver, and help regulate the functions of the retina. A selenium compound (I) was investigated in depth. I was a colorless, crystalline powder, soluble in water with a molecular weight of 341.5, and elemental composition C/sub 13/H/sub 25/SeNO/sub 2/. On the basis of experimental data, its LD/sub 50/ on s.c. administration to white mice was 600 mg/kg. I.v. injections of I in doses of 25-50 mg/kg showed no significant effect on the heart activity. A 75 mg/kg dose was fatal within 1-2 minutes after an i.v. administration. I.V. injection to cats at a dose of 50 mg/kg resulted in a transient drop of the arterial pressure which returned to normal after 5-10 minutes. The respiration rate and its amplitude decreased and returned gradually to normal level after 20-30 minutes. 18 references, 2 figures.

  11. Computational and Physical Analysis of Catalytic Compounds

    Science.gov (United States)

    Wu, Richard; Sohn, Jung Jae; Kyung, Richard

    2015-03-01

    Nanoparticles exhibit unique physical and chemical properties depending on their geometrical properties. For this reason, synthesis of nanoparticles with controlled shape and size is important to use their unique properties. Catalyst supports are usually made of high-surface-area porous oxides or carbon nanomaterials. These support materials stabilize metal catalysts against sintering at high reaction temperatures. Many studies have demonstrated large enhancements of catalytic behavior due to the role of the oxide-metal interface. In this paper, the catalyzing ability of supported nano metal oxides, such as silicon oxide and titanium oxide compounds as catalysts have been analyzed using computational chemistry method. Computational programs such as Gamess and Chemcraft has been used in an effort to compute the efficiencies of catalytic compounds, and bonding energy changes during the optimization convergence. The result illustrates how the metal oxides stabilize and the steps that it takes. The graph of the energy computation step(N) versus energy(kcal/mol) curve shows that the energy of the titania converges faster at the 7th iteration calculation, whereas the silica converges at the 9th iteration calculation.

  12. A new heterocyclic compound from Cyathula officinalis Kuan

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A new heterocyclic compound,named 5,5'-diisobutoxy-2,2'-bifuran(1),and four known compounds(2-5) were isolated from the roots of Cyathula officinalis Kuan.Their structures were elucidated by spectroscopic methods.Among these compounds,5,5'- dibutoxy-2,2'-bifuran(2) was isolated for the first time from this plant.

  13. Biodegradation of NSO-compounds under different redox-conditions

    DEFF Research Database (Denmark)

    Dyreborg, S.; Arvin, E.; Broholm, K.

    1997-01-01

    Laboratory experiments were carried out to investigate the potential of groundwater microorganisms to degrade selected heterocyclic aromatic compounds containing nitrogen, sulphur, or oxygen (NSO-compounds) under four redox-conditions over a period of 846 days. Eight compounds (pyrrole, 1-methylp...

  14. 46 CFR 153.1025 - Motor fuel antiknock compounds.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Motor fuel antiknock compounds. 153.1025 Section 153... Cargo Procedures § 153.1025 Motor fuel antiknock compounds. (a) No person may load or carry any other cargo in a containment system approved for motor fuel antiknock compounds containing lead alkyls...

  15. 46 CFR 151.50-6 - Motor fuel antiknock compounds.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Motor fuel antiknock compounds. 151.50-6 Section 151.50... BARGES CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-6 Motor fuel antiknock compounds. When transporting motor fuel antiknock compounds containing tetraethyl lead...

  16. Synthesis, Properties Characterization and Applications of Various Organobismuth Compounds

    Directory of Open Access Journals (Sweden)

    Jingfei Luan

    2011-05-01

    Full Text Available Organobismuth chemistry was emphasized in this review article due to the low price, low toxicity and low radioactivity characteristics of bismuth. As an environmentally-friendly class of organometallic compounds, different types of organobismuth compounds have been used in organic synthesis, catalysis, materials, etc. The synthesis and property characterization of many organobismuth compounds had been summarized. This review article also presented a survey of various applications of organobismuth compounds in organic transformations, as reagents or catalysts. The reactivity, reaction pathways and mechanisms of reactions with organobismuths were discussed. Less common and limiting aspects of organobismuth compounds were also briefly mentioned.

  17. [Analysis of sulfur compounds in residue fluid catalytic cracking gasoline].

    Science.gov (United States)

    Liang, Yong-mei; Liu, Wen-hui; Liu, Yao-fang

    2002-05-01

    Sulfur compounds in residue fluid catalytic cracking (RFCC) gasolines from Refinery of SINOPEC Beijing Yanshan Company and Refinery of Shijiazhuang were analyzed by gas chromatograph connected with flame photometric detector (FPD) and atomic emission detector (AED). Twelve and 26 kinds of sulfur compounds were detected by AED in RFCC gasolines from Yanshan and Shijiazhuang respectively. Only 0 and 19 kinds of sulfur compounds were found by FPD in these two gasolines respectively. The experimental results demonstrated that AED is more sensitive and selective to sulfur compounds than FPD. It also indicated that thiophenes were the major sulfur compounds in the RFCC gasoline. In addition, mercaptan, sulfoether and disulfide species were found.

  18. Materials Chemistry and Performance of Silicone-Based Replicating Compounds.

    Energy Technology Data Exchange (ETDEWEB)

    Brumbach, Michael T.; Mirabal, Alex James; Kalan, Michael; Trujillo, Ana B; Hale, Kevin

    2014-11-01

    Replicating compounds are used to cast reproductions of surface features on a variety of materials. Replicas allow for quantitative measurements and recordkeeping on parts that may otherwise be difficult to measure or maintain. In this study, the chemistry and replicating capability of several replicating compounds was investigated. Additionally, the residue remaining on material surfaces upon removal of replicas was quantified. Cleaning practices were tested for several different replicating compounds. For all replicating compounds investigated, a thin silicone residue was left by the replica. For some compounds, additional inorganic species could be identified in the residue. Simple solvent cleaning could remove some residue.

  19. Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei.

    Science.gov (United States)

    Tan, Wen-Jie; Xu, Jia-Cheng; Li, Li; Chen, Ke-Li

    2009-01-01

    Four flavone compounds were isolated from the effective fractions inhibiting xanthine oxidase (XOD) of the medicinal plant Selaginella labordei with anti-virus activity, and the structures were elucidated as 4'-methylether robustaflavone (1), robustaflavone (2), eriodictyol (3) and amentoflavone (4). The 50% inhibitory concentration (IC(50)) of the three compounds of inhibiting XOD were 61.0, 0.199, 16.0 and 32.0 mg L(-1), respectively. All of these compounds were isolated from the species for the first time, and eriodictyol was found from Selaginellaceae for the first time. Among these compounds, robustaflavone has been reported as an effective compound against the hepatitis B virus.

  20. Investigations on organolead compounds I. A novel red organolead compound a reinvestigation of krause's red diphenyllead

    NARCIS (Netherlands)

    Willemsens, L.C.; Kerk, G.J.M. van der

    1964-01-01

    A red organolead compound of the structure (Ph3Pb)4Pb has been obtained from the simultaneous hydrolysis and oxidation of ether-free triphenylplumbyllithium or diphenyllead at low temperatures. Its structure was established by analysis and by an iodination reaction which yielded one mole of lead dii

  1. Chemical stability of extemporaneously compounded omeprazole formulations: a comparison of two methods of compounding.

    Science.gov (United States)

    Garg, Sanjay; Svirskis, Darren; Al-Kabban, Majid; Farhan, Samer; Komeshi, Mohammed; Lee, Jacky; Liu, Quincy; Naidoo, Sacha; Kairuz, Therese

    2009-01-01

    Liquid preparations of omeprazole are compounded extemporaneously for patients who cannot tolerate or have difficulty with tablets or capsules, such as those with a nasogastric tube or jejunal or feeding tube, those with a swallowing disorder, and young children and the elderly. Recommendations for preparation of a liquid from the enteric-coated pellets of omeprazole capsules are available in the literature. The pellets are dissolved in a sodium bicarbonate solution; shaking is recommended to aid dissolution. Apparently some pharmacists crush the pellets to speed up the compounding process. The aim of this study was to investigate the chemical stability of omeprazole in extemporaneously compounded liquids prepared by the grinding and shaking methods. A high-performance liquid chromatographic method was developed for evaluation of chemical stability. Samples were stored at 2 deg C (refrigerated conditions) or 25 deg C/60% relative humidity and assayed for drug concentration at 0, 1, 2, 4, and 8 weeks. The method of preparation affected the chemical stability of omeprazole when stored at 25 deg C/60% relative humidity; it was stable for 4 weeks if prepared by the shaking method, but for only 1 week if prepared by the grinding method. For both methods, the suspension was stable for 8 weks if stored under refrigerated conditions. It is recommended that the shaking method be employed for extemporaneously compounded omeprazole suspensions, and that the prepared suspension be stored in the refrigerator.

  2. Occupational asphyxiation by unknown compound(s): environmental and toxicological approach.

    Science.gov (United States)

    Poli, D; Solarino, B; Di Vella, G; Tattoli, L; Strisciullo, G; Goldoni, M; Mutti, A; Gagliano-Candela, R

    2010-04-15

    During a routine truck-tank washing operation, five healthy workers were found motionless inside an empty tanker. Four of them died inside the tanker while the fifth died the following day in hospital. Since the true nature of the fatal compound(s) were not known, a rigorous environmental and toxicological approach supported by autopsy findings was essential to clarify the cause of death. Environmental results indicated that H(2)S fumes arising from the liquid sulfur previously shipped were responsible for the serial deaths, also confirmed by a simulation performed on two similar truck-tanks. These environmental findings were supported by toxicological analyses through the measurement of thiosulfate, one of the main H(2)S metabolites. Abnormal thiosulfate concentrations from 1.1 to 186.2 mg/kg were revealed in all post-mortem biological samples (blood, lung, liver, kidney, brain and fat). Finally, the cluster analysis performed on thiosulfate body distribution contributed to establishing the time of death according to the accident scene reconstruction. This report presents valuable findings in correctly identifying the cause of death in gas asphyxiation cases by unknown compound(s).

  3. Emission of volatile organic compounds from silage: compounds, sources, and implications

    Science.gov (United States)

    Silage, fermented cattle feed, has recently been identified as a significant source of volatile organic compounds (VOCs) emitted to the atmosphere. A small number of studies have measured VOC emission from silage, but not enough is known about the processes involved to accurately quantify emission r...

  4. Investigations on organolead compounds III. The reaction of organolead compounds with ketene. (Triphenylplumbyl)acetic anhydride

    NARCIS (Netherlands)

    Willemsens, L.C.; Kerk, G.J.M. van der

    1965-01-01

    The reaction of ketene with triphenyllead hydroxide in diethyl ether gave (triphenylplumbyl)acetic anhydride, (Ph3PbCH2CO)2O, the first anhydride-substituted organolead compound known. The reaction of ketene with triphenyllead acetate in absolute ethanol gave ethyl (triphenylplumbyl)acetate, Ph3PbCH

  5. Trace compounds affecting biogas energy utilisation - A review

    Energy Technology Data Exchange (ETDEWEB)

    Rasi, S., E-mail: saija.rasi@gmail.com [University of Jyvaeskylae, Department of Biological and Environmental Science, P.O. Box 35, FI-40014 (Finland); Laentelae, J.; Rintala, J. [University of Jyvaeskylae, Department of Biological and Environmental Science, P.O. Box 35, FI-40014 (Finland)

    2011-11-15

    Highlights: {yields} In regards to trace compounds, landfill gases are the most studied biogases. {yields} More strict requirements are set for biogas purity with new biogas applications. {yields} With traditional applications, small variations in biogas quality are acceptable. {yields} New requirements set challenges on raw material control and biogas quality. {yields} In this study, variations in analysing methods and biogas quality are discussed. - Abstract: This paper investigates the trace compounds affecting energy utilisation in biogas that come from different production sites. With biogas being more widely used in different energy applications more interest has arisen for the specific composition of biogas. In traditional energy applications, methane and hydrogen sulphide contents have had the most influence when energy utilisation application has been considered. With more advanced processes also the quantity and quality of trace compounds is more important. In regards to trace compounds, it was found that the concentrations and the variations of volatile organic compounds (VOCs) can be high in different landfills, especially, with compounds originating from the biological degradation process (like aromatics and terpenes) as seasonal variations affect the biological degradation. Trace compounds produced by direct volatilisation (halogenated and silicon compounds) show a smaller seasonal variation. Halogenated compounds are rarely present in high concentrations in waste water treatment plant (WWTP) biogas, but the concentrations of organic silicon compounds and their variation is high. Organic silicon compounds are usually detected only in low concentrations in co-digestion plant biogas, when no WWTP sludge is used as a raw material.

  6. Synthesis, Chemistry, and Applications of Heterocyclic Cage Compounds (V)

    Institute of Scientific and Technical Information of China (English)

    WU; Hsien-Jen

    2001-01-01

    The synthesis and chemistry of polycyclic of cage compounds have attracted considerable attention in recent years. The vast majority of the work reported in this area has dealt with carbocylic cage compounds. On the other hand, the synthesis and chemistry of heterocyclic cage compounds have received less attention. Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.1 As part of a program that involves the synthesis, chemistry, and application of heterocyclic cage compounds, we report here the synthesis of new thia-oxa-cage compounds and the chemical nature of these thia-cages.  ……

  7. Trichloromethyl compounds - natural background concentrations and fates within and

    DEFF Research Database (Denmark)

    Albers, Christian Nyrop; Hansen, Poul Erik; Jacobsen, Ole Stig

    2010-01-01

    occurrence and cycling of organic compounds with a trichloromethyl moiety in common. The study areas are temperate coniferous forests. Trichloromethyl compounds can be found in all compartments of the forests (groundwater, soil, vegetation and throughfall), but not all compounds in all compartments....... The atmospheric input of trichloromethyl compounds is found to be minor, with significant contributions for trichloroacetic acid (TCAA), only. In top soil, where the formation of the compounds is expected to occur, there is a clear positive relationship between chloroform and trichloroacetyl containing compounds....... Other positive relations occur, which in combination with chlorination experiments performed in the laboratory, point to the fact that all the trichloromethyl compounds may be formed concurrently in the soil, and their subsequent fates then differ due to different physical, chemical and biological...

  8. Identification of Antioxidant Compounds Structure Large-Leafed Mangrove Fruit

    Directory of Open Access Journals (Sweden)

    Sabri Sudirman

    2016-08-01

    Full Text Available Antioxidants are compounds that can inhibit or prevent the oxidation of the easily oxidized substrate.One of the plants as a potential source of bioactive compounds and antioxidant activity is large-leafedmangrove (Bruguiera gymnorrhiza. This plant is commonly found in the Pacific region of Southeast Asia,Ryukyu Islands, Micronesia and Polynesia (Samoa to subtropical regions of Australia and has been usedby the society. This study aimed to determine the bioactive compounds structure of large-leafed mangrovehas the highest antioxidant activity. The compound structure prediction was done by Nuclear MagneticResonance (NMR. The compound structure in the selected antioxidant fractions are flavonol, glikosilfalvonand flavon. Those three compounds are flavonoid compound which has a great role as the one that hasantioxidant activity in large-leafed mangrove fruit.

  9. A New Natural Compound with Cytotoxic Activity from Tripterygium hypoglaucum

    Institute of Scientific and Technical Information of China (English)

    LI Wei; WANG Fang; ZHAO Yu-qing

    2011-01-01

    Objective To find antitumor cOnstituents from Tripterygium hypoglaucum.Methods The chloroform extract of T.hypoglaucum was separated by silica gel column chromatography and preparative HPLC.The structures of compounds isolated were identified by spectral analysis and chemical evidence.Results Seven compounds were isolated and identified as rhein ethyl ester(1),chrysophenol(2),physcion(3),emodin(4),wilfordine(5),wilforgine(6),and wilforine(7).The cytotoxic activities of the compounds against cancer cell lines were assayed.Conclusion Compound 1 is a new natural compound with strong activities against human cancer cell lines (A2780 and OVCAR-3).Compounds 2-4 are isolated from this genus plants for the first time.The possible structure-activity relationship among compounds 1-4 shows that the methoxy group or oxyethyl moiety might be responsible for the cytotoxity.

  10. Chemical and pharmacological characterization of hypolipidemic compound from Cajanus Cajan

    Directory of Open Access Journals (Sweden)

    Md. Anwar Habib

    2010-03-01

    Full Text Available The study was carried out to identify the compound responsible for hypolipidemic and hypoglycemic effects of Cajanus cajan (redgram. The methanol extract of redgram seeds were fractionated into petroleum ether, chloroform, and methanol. The methanol fraction significantly decreased fasting blood glucose, and lipid profiles (p<0.001 on streptozotocin-induced mice compared to control. The methanol fraction was then subjected to chromatographic analysis and a compound (CCA1 has been isolated. The structure of the compound is considered to be substituted cyclopentene with glucose by analysis its 1H and 13C-NMR data. Biological studies of the isolated compound possessed prominent hypolipidemic activity. Although a number of hypoglycemic compounds are reported, yet not any hypolipidemic compound from redgram. The compound CCA1 seems to be the first report on hypolipidemic activity from methanol extract of redgram.

  11. Preliminary classification of characteristic organic gunshot residue compounds.

    Science.gov (United States)

    Goudsmits, Ellen; Sharples, George P; Birkett, Jason W

    2016-12-01

    For the first time, a classification system for organic gunshot residue (OGSR) compounds with respect to the confirmation of OGSR materials is presented. There are 136 compounds considered to be associated with OGSR that have been highlighted in the literature. Many of these compounds could be classified as being ubiquitous in the environment and thus their detection as characteristic components of OGSR could cause issues with the interpretation of chemical ballistic evidence. The proposed system aims to address this problem by classifying OGSR compounds based on their forensic relevance with respect to the confirmation of GSR materials. To increase the forensic relevance of such a system, the large number of OGSR compounds reported in the literature has been decreased to 20 OGSR compounds based on the organic chemical composition of over 200 propellant powders. Occupational and environmental materials also associated with OGSR compounds have been considered.

  12. Characterization of Titanium-Containing Compounds in Gray Iron

    Institute of Scientific and Technical Information of China (English)

    ZENG Daxin; ZHANG Yuanhao; LIU Jianyong; HE Hanjun; HONG Xiaoxian

    2008-01-01

    Titanium produces different compounds in gray iron. In order to determine their characteristics, a scanning electron microscope, an energy dispersive X-ray spectroscopy, and an optical microscopy were used to analyze the morphology, distribution, and composition of titanium-containing compounds in metal-lographic specimens and machined surfaces in four gray irons. The results show that the titanium-containing compounds in the gray irons are complex compounds containing V, Nb, Mn, S, and other metals, depending on the concentration of these elements in the iron. The number of titanium-containing compounds increases with increasing Ti content in the gray iron. Most of the titanium-containing compounds are located in the peariite matrix, with some in the steadite and carbides. The results suggest that titanium-containing com-pounds reduce tool lifetime.

  13. Molecular structure of diatomic lanthanide compounds

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The molecular constants of selected diatomic lanthanide compounds(LaH, LaO, LaF, EuH, EuO, EuF, EuS, GdO, GdF, GdH, YbH, YbO, YbF, YbS, LuH, LuO and LuF) have been calcu-lated by using relativistic small-core pseudopotentials and optimized(14s13p10d8f6g)/ [6s6p5d4f3g] valence basis sets. The results are in good agreement with available experimental data, with exception of YbO and LuF. The reasons for the discrepancies in case of YbO are due to a complicated mixing of configurations in the ground state, whereas in case of LuF the binding energy estimated by experimentalists appears to be too low.

  14. Phenolic compounds from Anaphalis aureo-punctata

    Institute of Scientific and Technical Information of China (English)

    WU Yan-Qi; LOU Ning; LI Yu

    2003-01-01

    @@ From the ethanolic extract of the whole plant of Anaphalis aureo-punctata, a new acylated flavonoid glycoside 3-O-kaempferol-3-O-acetyl-6-O-(p-coumaroyl)-β-D-glucopyranoside (1), and five known phenolic compounds 3-O-kaempferol-6- O- ( p-coumaroyl )-β-D-glucopyranoside ( 2 ), kaempferol-3- O-β-D-glucopyranoside 3,6-(4′-hydroxystyryl)-4-methoxy-2-pyrone (4), 2H-pyran-2-one, 6-[ 2-( 4-(β-D-glucopyranosyloxy ) phenyl ) ethenyl ]-4-methoxy-( E ) (5) and 4-hydroxy-3-methoxycinnamic hexacosyl ester (6) were isolated. Their structures were established by spectral methods (UV, IR, MS, 1D, 2D-NMR). The flavonoid glycosides, 1, 2 and 3 showed markedly inhibited oxidative DNA strand breaks induced by Fenton reaction and NADH/PMS in a concentration-dependent manner.

  15. [Studies on chemical compounds of Chlorella sorokiniana].

    Science.gov (United States)

    Zhang, Ling; Liu, Ping-huai; Wu, Jiao-na; Yang, Guo-fu; Suo, Yang-yang; Luo, Ning; Chen, Chen

    2015-04-01

    Chemical constituents of Chlorella sorokiniana were isolated and purified by repeated column chromatographies, over silicagel and Sephadex LH-20. Their structures were identified on the basis of physicochemical properties and spectroscopic data analysis. Five compounds were obtained from the petroleum ether extract of Chlorella sorokiniana, and their structures were identified as (22E, 24R)-5alpha, 3beta-epidioxiergosta-6, 22-dien-3beta-ol(1),(24S)-ergosta-7-en-3beta-ol(2), loliolide(3), stigmasta-7,22-dien-3beta,5alpha,6alpha-triol(4), and 3beta-hydroxy-5alpha,6alpha-epoxy-7-megastigmen-9-one(5). The main liposoluble fractions from Chlorella sorokiniana maiuly contain fatty acids, alkyl acids and olefine acids. Components 1-5 were isolated from the genus Chlorella for the first time.

  16. PUNGENT AND COLOUR COMPOUNDS OF RED PEPPERS

    Directory of Open Access Journals (Sweden)

    Çetin KADAKAL

    2001-03-01

    Full Text Available The capcaicinoid amount of red peppers from Solanacea family is used for the evaluation of quality and classification in many countries. Capsaicin is the major pungent principle (69 % of capsaicinoids. The others are dihidrocapsaicin (22 %, nordihidrocapsaicin (7 %, homocapsaicin (1 % and homodihidrocapsaicin (1 %. As in most foods, the carotenoids of red peppers are also important compounds. Carotenoids are typical colour pigments and some of them have vitamin A activity. Major carotenoids of ripe fruit of red peppers are capsanthin, capsorubin, ß-carotene and zeaxanthin. Capcaicinoid and carotenoid contents of red peppers grown in many different regions of the world, their properties and roles on the human health were given in this review.

  17. Molecular structure of diatomic lanthanide compounds

    Institute of Scientific and Technical Information of China (English)

    曹晓燕; 刘文剑; MichaelDolg

    2002-01-01

    The molecular constants of selected diatomic lanthanide compounds (LaH, LaO, LaF, EuH, EuO, EuF, EuS, GdO, GdF, GdH, YbH, YbO, YbF, YbS, LuH, LuO and LuF) have been calculated by using relativistic small-core pseudopotentials and optimized (14s13p10d8f6g)/ [6s6p5d4f3g] valence basis sets. The results are in good agreement with available experimental data, with exception of YbO and LuF. The reasons for the discrepancies in case of YbO are due to a complicated mixing of configurations in the ground state, whereas in case of LuF the binding energy estimated by experimentalists appears to be too low.

  18. Clathrate compounds and method of manufacturing

    Science.gov (United States)

    Nolas, George S.; Witanachchi, Sarath; Mukherjee, Pritish

    2009-05-19

    The present invention comprises new materials, material structures, and processes of fabrication of such that may be used in technologies involving the conversion of light to electricity and/or heat to electricity, and in optoelectronics technologies. The present invention provide for the fabrication of a clathrate compound comprising a type II clathrate lattice with atoms of silicon and germanium as a main framework forming lattice spacings within the framework, wherein the clathrate lattice follows the general formula Si.sub.136-yGe.sub.y, where y indicates the number of Ge atoms present in the main framework and 136-y indicates the number of Si atoms present in the main framework, and wherein y>0.

  19. Forging of FeAl intermetallic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Flores, O.; Juarez, J.; Campillo, B.; Martinez, L. [UNAM, Cuernavaca (Mexico). Lab. de Cuernavaca; Schneibel, J.H. [Oak Ridge National Lab., TN (United States)

    1994-09-01

    Much activity has been concentrated on the development of intermetallic compounds with the aim of improving tensile ductility, fracture toughness and high notch sensitivity in order to develop an attractive combination of properties for high and low temperature applications. This paper reports experience in processing and forging of FeAl intermetallic of B2 type. During the experiments two different temperatures were employed, and the specimens were forged after annealing in air, 10{sup {minus}2} torr vacuum and argon. From the results it was learned that annealing FeAl in argon atmosphere prior to forging resulted in better deformation behavior than for the other two environments. For the higher forging temperature used in the experiments (700C), the as-cast microstructure becomes partially recrystallized.

  20. Biorefining compounds and organocatalytic upgrading methods

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Eugene Y.; Liu, Dajiang

    2016-10-18

    The invention provides new methods for the direct umpolung self-condensation of 5-hydroxymethylfurfural (HMF) by organocatalysis, thereby upgrading the readily available substrate into 5,5'-di(hydroxymethyl)furoin (DHMF). While many efficient catalyst systems have been developed for conversion of plant biomass resources into HMF, the invention now provides methods to convert such nonfood biomass directly into DHMF by a simple process as described herein. The invention also provides highly effective new methods for upgrading other biomass furaldehydes and related compound to liquid fuels. The methods include the organocatalytic self-condensation (umpolung) of biomass furaldehydes into (C.sub.8-C.sub.12)furoin intermediates, followed by hydrogenation, etherification or esterification into oxygenated biodiesel, or hydrodeoxygenation by metal-acid tandem catalysis into premium hydrocarbon fuels.

  1. Impacted permanent incisors associated with compound odontoma.

    Science.gov (United States)

    Machado, Cintia de Vasconcellos; Knop, Luégya Amorin Henriques; da Rocha, Maria Celina Barreiros Siquara; Telles, Paloma Dias da Silva

    2015-01-12

    Odontomas are the most common odontogenic tumours of the maxillary bones, characterised by a slow growth and benign behaviour. They are usually small, asymptomatic and diagnosed after routine radiographic examination. The aim of this study was to report a case of a compound odontoma in the anterior maxilla of a 7-year-old girl, which was causing the impaction of the maxillary right central and lateral incisors, as well as the prolonged retention of the corresponding primary teeth. We also aimed to review the literature about these tumours, since they are not part of the dentist's day-to-day clinical practice. The clinical and radiographic features, the diagnosis and treatment of the case were discussed in this work.

  2. Structural studies of naturally occurring toxicogenic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Springer, J. P.

    1977-10-01

    The paralytic shellfish poison (PSP), saxitoxin, is a neurotoxin isolated from Alaska butter clams (Saxidomus giganteus), mussels (Mytilus californianus) and axenic cultures of the dinoflagellate Gonyaulax catenella. The structure of saxitoxin has been determined through the use of single crystal X-ray diffraction. It possesses a unique tricyclic arrangement of atoms containing two guanidinium moieties and also a hydrated ketone. The relative stereochemistry is presented as well as the absolute configuration. The chemical constitution of a tremorgenic metabolite, paxilline, isolated from extracts of the fungus Penicillium paxilli Bainier has been determined. Paxilline represents a previously unreported class of natural compounds formed by the combination of tryptophan and mevalonate subunits. The complete stereostructure of two other fungal metabolites, paspaline and paspalicine, closely related to paxilline but isolated from Claviceps paspali Stammes have also been determined and are presented. The stereochemistries of paxilline, paspaline and paspalicine are identical at corresponding chiral centers.

  3. Laser ablation of molecular carbon nitride compounds

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D., E-mail: d.fischer@fkf.mpg.de [Max Planck Institute for Solid State Research, Heisenbergstr. 1, 70569 Stuttgart (Germany); Schwinghammer, K. [Max Planck Institute for Solid State Research, Heisenbergstr. 1, 70569 Stuttgart (Germany); Department of Chemistry, University of Munich, LMU, Butenandtstr. 5-13, 81377 Munich (Germany); Nanosystems Initiative Munich (NIM) and Center for Nanoscience (CeNS), 80799 Munich (Germany); Sondermann, C. [Max Planck Institute for Solid State Research, Heisenbergstr. 1, 70569 Stuttgart (Germany); Department of Chemistry, University of Munich, LMU, Butenandtstr. 5-13, 81377 Munich (Germany); Lau, V.W.; Mannhart, J. [Max Planck Institute for Solid State Research, Heisenbergstr. 1, 70569 Stuttgart (Germany); Lotsch, B.V. [Max Planck Institute for Solid State Research, Heisenbergstr. 1, 70569 Stuttgart (Germany); Department of Chemistry, University of Munich, LMU, Butenandtstr. 5-13, 81377 Munich (Germany); Nanosystems Initiative Munich (NIM) and Center for Nanoscience (CeNS), 80799 Munich (Germany)

    2015-09-15

    We present a method for the preparation of thin films on sapphire substrates of the carbon nitride precursors dicyandiamide (C{sub 2}N{sub 4}H{sub 4}), melamine (C{sub 3}N{sub 6}H{sub 6}), and melem (C{sub 6}N{sub 10}H{sub 6}), using the femtosecond-pulsed laser deposition technique (femto-PLD) at different temperatures. The depositions were carried out under high vacuum with a femtosecond-pulsed laser. The focused laser beam is scanned on the surface of a rotating target consisting of the pelletized compounds. The resulting polycrystalline, opaque films were characterized by X-ray powder diffraction, infrared, Raman, and X-ray photoelectron spectroscopy, photoluminescence, SEM, and MALDI-TOF mass spectrometry measurements. The crystal structures and optical/spectroscopic results of the obtained rough films largely match those of the bulk materials.

  4. Fast Screening of Antibacterial Compounds from Fusaria

    Directory of Open Access Journals (Sweden)

    Teis Esben Sondergaard

    2016-11-01

    Full Text Available Bio-guided screening is an important method to identify bioactive compounds from fungi. In this study we applied a fast digital time-lapse microscopic method for assessment of the antibacterial properties of secondary metabolites from the fungal genus Fusarium. Here antibacterial effects could be detected for antibiotic Y, aurofusarin, beauvericin, enniatins and fusaric acid after six hours of cultivation. The system was then used in a bio-guided screen of extracts from 14 different Fusarium species, which had been fractionated by HPLC. In this screen, fractions containing the red pigments aurofusarin and bikaverin showed effects against strains of Lactobacillus and Bifidobacterium. The IC50 for aurofusarin against Lactobacillus acidophilus was 8 µM, and against Bifidobacterium breve it was 64 µM. Aurofusarin only showed an effect on probiotic bacteria, leading to the speculation that only health-promoting bacteria with a positive effect in the gut system are affected.

  5. Cytotoxic compounds from endemic Arnebia purpurea.

    Science.gov (United States)

    Yuzbasioglu, Merve; Kuruuzum-Uz, Ayse; Guvenalp, Zuhal; Simon, András; Tóth, Gabór; Harput, U Sebnem; Kazaz, Cavit; Bilgili, Bilgehan; Duman, Hayri; Saracoglu, Iclal; Demirezer, L Omur

    2015-04-01

    Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

  6. Biorefining compounds and organocatalytic upgrading methods

    Science.gov (United States)

    Chen, Eugene Y.; Liu, Dajiang

    2016-10-18

    The invention provides new methods for the direct umpolung self-condensation of 5-hydroxymethylfurfural (HMF) by organocatalysis, thereby upgrading the readily available substrate into 5,5'-di(hydroxymethyl)furoin (DHMF). While many efficient catalyst systems have been developed for conversion of plant biomass resources into HMF, the invention now provides methods to convert such nonfood biomass directly into DHMF by a simple process as described herein. The invention also provides highly effective new methods for upgrading other biomass furaldehydes and related compound to liquid fuels. The methods include the organocatalytic self-condensation (umpolung) of biomass furaldehydes into (C.sub.8-C.sub.12)furoin intermediates, followed by hydrogenation, etherification or esterification into oxygenated biodiesel, or hydrodeoxygenation by metal-acid tandem catalysis into premium hydrocarbon fuels.

  7. Coaxial Compound Helicopter for Confined Urban Operations

    Science.gov (United States)

    Johnson, Wayne; Elmore, Joshua F.; Keen, Ernest B.; Gallaher, Andrew T.; Nunez, Gerardo F.

    2016-01-01

    A rotorcraft was designed for military operations in a confined urban environment. The specifications included major increases in useful load, range, and speed relative current aircraft capabilities, with a size constraint based on the dimensions of urban streets and intersections. Analysis showed that this combination of requirements is best satisfied by a coaxial main-rotor configuration, with lift compounding to off-load the rotors at high speed, and ducted fans under the rotor disk for propulsion. The baseline design is described, and the aircraft performance is summarized for utility, attack, MEDEVAC, and cargo delivery missions. The impact on size and performance is examined for a number of excursions, including lift-offset main rotors. Technology development required to achieve this advance in capability is recommended.

  8. Carbonyl compounds indoors in a changing climate

    Directory of Open Access Journals (Sweden)

    Brimblecombe Peter

    2012-03-01

    Full Text Available Abstract Background Formic acid, acetic acid and formaldehyde are important compounds in the indoor environment because of the potential for these acids to degrade calcareous materials (shells, eggs, tiles and geological specimens, paper and corrode or tarnish metals, especially copper and lead. Carbonyl sulfide tarnishes both silver and copper encouraging the formation of surface sulfides. Results Carbonyls are evolved more quickly at higher temperatures likely in the Cartoon Gallery at Knole, an important historic house near Sevenoaks in Kent, England where the study is focused. There is a potential for higher concentrations to accumulate. However, it may well be that in warmer climates they will be depleted more rapidly if ventilation increases. Conclusions Carbonyls are likely to have a greater impact in the future.

  9. Volatile organic compound detection using nanostructured copolymers.

    Science.gov (United States)

    Li, Bo; Sauvé, Genevieve; Iovu, Mihaela C; Jeffries-El, Malika; Zhang, Rui; Cooper, Jessica; Santhanam, Suresh; Schultz, Lawrence; Revelli, Joseph C; Kusne, Aaron G; Kowalewski, Tomasz; Snyder, Jay L; Weiss, Lee E; Fedder, Gary K; McCullough, Richard D; Lambeth, David N

    2006-08-01

    Regioregular polythiophene-based conductive copolymers with highly crystalline nanostructures are shown to hold considerable promise as the active layer in volatile organic compound (VOC) chemresistor sensors. While the regioregular polythiophene polymer chain provides a charge conduction path, its chemical sensing selectivity and sensitivity can be altered either by incorporating a second polymer to form a block copolymer or by making a random copolymer of polythiophene with different alkyl side chains. The copolymers were exposed to a variety of VOC vapors, and the electrical conductivity of these copolymers increased or decreased depending upon the polymer composition and the specific analytes. Measurements were made at room temperature, and the responses were found to be fast and appeared to be completely reversible. Using various copolymers of polythiophene in a sensor array can provide much better discrimination to various analytes than existing solid state sensors. Our data strongly indicate that several sensing mechanisms are at play simultaneously, and we briefly discuss some of them.

  10. Syntheses and studies of organosilicon compounds

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Ren [Iowa State Univ., Ames, IA (United States)

    1999-02-12

    The syntheses of polycarbosilanes and polysilanes as silicon carbide ceramic precursors have been active research areas in the Barton Research Group. In this thesis, the work is focused on the preparation of polycarbosilanes and polysilanes as stoichiometric silicon carbide precursor polymers. The syntheses of the precursor polymers are discussed and the conversions of these precursors to silicon carbide via pyrolysis are reported. The XRD pattern and elemental analyses of the resulting silicon carbide ceramics are presented. Silicon monoxide is an important intermediate in the production of silicon metal. The existence of silicon monoxide in gap phase has been widely accepted. In the second part of this thesis, the generation of gaseous silicon monoxide in four different reactors and the reactions of gaseous silicon monoxide towards organic compounds are discussed.

  11. Ternary compound thin film solar cells

    Science.gov (United States)

    Kazmerski, L. L.

    1975-01-01

    A group of ternary compound semiconductor (I-III-VI2) thin films for future applications in photovoltaic devices is proposed. The consideration of these materials (CuInSe2, CuInTe2 and especially CuInS2) for long range device development is emphasized. Much of the activity to date has been concerned with the growth and properties of CuInX2 films. X-ray and electron diffraction analyses, Hall mobility and coefficient, resistivity and carrier concentration variations with substrate and film temperature as well as grain size data have been determined. Both p- and n-type films of CuInS2 and CuInSe2 have been produced. Single and double source deposition techniques have been utilized. Some data have been recorded for annealed films.

  12. Antileishmanial compounds from Moringa oleifera Lam.

    Science.gov (United States)

    Kaur, Amandeep; Kaur, Preet Kamal; Singh, Sushma; Singh, Inder Pal

    2014-01-01

    The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam. was investigated in vitro against promastigotes of Leishmania donavani. The 70% ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of 83.0 microg/ml and 47.5 microg/ml, respectively. Antileishmanial activity of the methanolic extract of leaves increased upon fractionation, as its ethyl acetate fraction was found to be more active with an IC50 value of 27.5 microg/ml. The most active antileishmanial compound niazinin, a thiocarbamate glycoside isolated from this fraction, showed an IC50 value of 5.25 microM. Results presented in this study indicate that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.

  13. Variability of antinutritive compounds in flaxseed flours

    Directory of Open Access Journals (Sweden)

    Roberto Russo

    2013-09-01

    Full Text Available The use of flaxseed flours in the diets of poultry and broilers may be limited by the presence of antinutritive compounds. The content of cyanogenic glycosides, phytic acid, condensed tannins and trypsin inhibitors was evaluated in seven varieties of Linum usitatissimum. Phytic acid, condensed tannins and trypsin inhibitors showed significant differences among varieties. Only the concentration of cyanogenic glycosides and phytic acid in the flour deserves attention, while the content of condensed tannins and trypsin inhibitors are to acceptable levels. Since the flax meal is an important source of omega-3 for poultry and broilers, the cyanogenic glycoside and phytic acid contents in linseed has to be reduced to increase the ration to be included in the diet.

  14. Multiple compound odontomas in mandible: A rarity

    Directory of Open Access Journals (Sweden)

    Sanjeev Vaid

    2012-01-01

    Full Text Available Odontomas are benign odontogenic tumors composed of enamel, dentine, and cementum and pulp tissue. They are usually clinically asymptomatic, but often associated with tooth eruption disturbances. The present study reports an unusual case of eleven odontomas in the left lateral incisor-canine region of lower jaw. A 26 years old female presented to the department of orthodontics and dentofacial orthopedics in H.P. Govt. Dental College and Hospital Shimla for the treatment of misaligned teeth. Clinical examination revealed that the lower left lateral incisor was missing. Patient was advised for radiographs, which revealed a mixed radiopaque lesion associated to impacted lower left canine. The histological report in this case indicated a compound odontoma.

  15. A REVIEW: BIOLOGICAL SIGNIFICANCES OF HETEROCYCLIC COMPOUNDS.

    Directory of Open Access Journals (Sweden)

    Mukhtyar. S. Saini

    2013-03-01

    Full Text Available Heterocyclic chemistry offers an example for the lack of distinct demarcations; in fact, it pervades the plurality of the other chemical disciplines. Heterocycles are inextricably woven into the life processes. The vital interest of the pharmaceutical and agrochemical industries in heterocycles is often connected with their natural occurrence. Synthetic chemistry provides cornucopia of heterocyclic systems. More than 90% of new drugs contain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. This review article covers the most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant, antiallergic, herbicidal, anticancer activity

  16. Organic compounds as indicators of air pollution

    DEFF Research Database (Denmark)

    Mølhave, Lars

    2003-01-01

    The most important indoor air pollutants have already been addressedwith individual national guidelines or recommendations. However, an interna-tional set of guidelines or recommendations for indoor air quality (IAQ) isneeded for these pollutants based on general and uniform rules for setting...... suchstandards. A major research need exist on the less adverse pollutants beforerecommendations or guidelines can be established. In the interim period a pre-caution principle should lead to an ALARA principle for these secondary cau-salities. It should be noted that volatile organic compound (VOC......) is an indicatorfor the presence of VOC indoors. The TVOC indicator can be used in relation toexposure characterization and source identification but for VOCs only, not as anindictor of other pollutants and their health effects. In risk assessment the TVOCindicator can only be used as a screening tool and only...

  17. Minor lipophilic compounds in edible insects

    Directory of Open Access Journals (Sweden)

    Monika Sabolová

    2016-07-01

    Full Text Available Contemporary society is faced with the question how to ensure suffiecient nutrition (quantity and quality for rapidly growing population. One solution can be consumption of edible insect, which can have very good nutritional value (dietary energy, protein, fatty acids, fibers, dietary minerals and vitamins composition. Some edible insects species, which contains a relatively large amount of fat, can have a potential to be a „good" (interesting, new source of minor lipophilic compounds such as sterols (cholesterol and phytosterols and tocopherols in our diet. For this reason, the objective of this work was to characterize the sterols and tocopherols composition of fat from larvae of edible insect Zophobas morio L. and Tenebrio mollitor L. Cholesterol and three phytosterols (campesterol, stigmasterol and β-sitosterol were reliably identified and quantified after hot saponification and derivatization by GC-MS. Other steroid compounds, including 5,6-trans-cholecalciferol were identified only according to the NIST library. Cholesterol was the predominant sterol in all analysed samples. Both types of larvae also contained high amount of phytosterols. Different region of origin had a no significant impact on sterols composition, while the effect of beetle genus was crucial. Tocopherols were analysed by reverse phase HPLC coupled with amperometric detection. Tocopherols content in mealworm larvae was lower than content in edible oils, but important from the nutritional point of view. Change of tocopherols composition was not observed during the storage under different conditions. Larvae of edible insect can be a potential good dietary source of cholesterol, but also vitamin D3 isomers, phytosterols and tocopherols.  

  18. Historeceptomic fingerprints for drug-like compounds

    Directory of Open Access Journals (Sweden)

    Evgeny eShmelkov

    2015-12-01

    Full Text Available Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology. The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the receptors upon which a drug acts and their level of expression in organs/tissues. Conversely, the fingerprint of the adverse effects of a drug may derive from its action in bystander tissues. The ensemble of targets is almost always only partially known. Here we describe an approach improving upon and integrating both components: in silico identification of a more comprehensive ensemble of targets for any drug weighted by the expression of those receptors in relevant tissues. Our system combines more than 300K experimentally determined bioactivity values from the ChEMBL database and 4.2 billion generated molecular docking scores. We integrated these scores with gene expression data for human receptors across a panel of human tissues to produce drug-specific tissue-receptor (historeceptomics scores. A statistical model was designed to identify significant scores, which define an improved fingerprint representing the unique activity of any drug. These multi-dimensional historeceptomic fingerprints describe, in a novel, intuitive, and easy to interpret style, the holistic picture of the mechanism of any drug’s action. Valuable applications in drug discovery and personalized medicine, including the identification of molecular signatures for drugs with polypharmacologic modes of action, detection of tissue-specific adverse effects of drugs, matching molecular signatures of a disease to drugs, target identification for bioactive compounds with unknown receptors, and hypothesis generation for drug/compound phenotypes may be enabled by this approach. The system has been deployed at drugable.org for access through a user-friendly web site.

  19. Investigations on organozinc compounds XII. Coordination chemistry of organozinc compounds RZnX: Organozinc compounds of the type EtZnNPhCSZ

    NARCIS (Netherlands)

    Boersma, J.; Noltes, J.G.

    1969-01-01

    The coordination chemistry of the organozinc-nitrogen compounds EtZnNPhCSZ (Z = H, Me, OMe, SMe and NPh2) has been studied. Whereas the benzeneinsoluble EtZnNPhCSH appears to be a coordination polymer, all the other compounds occur as dimers in benzene solution. A structure with four-coordinate zinc

  20. Antiviral Screening of Multiple Compounds against Ebola Virus

    Directory of Open Access Journals (Sweden)

    Stuart D. Dowall

    2016-10-01

    Full Text Available In light of the recent outbreak of Ebola virus (EBOV disease in West Africa, there have been renewed efforts to search for effective antiviral countermeasures. A range of compounds currently available with broad antimicrobial activity have been tested for activity against EBOV. Using live EBOV, eighteen candidate compounds were screened for antiviral activity in vitro. The compounds were selected on a rational basis because their mechanisms of action suggested that they had the potential to disrupt EBOV entry, replication or exit from cells or because they had displayed some antiviral activity against EBOV in previous tests. Nine compounds caused no reduction in viral replication despite cells remaining healthy, so they were excluded from further analysis (zidovudine; didanosine; stavudine; abacavir sulphate; entecavir; JB1a; Aimspro; celgosivir; and castanospermine. A second screen of the remaining compounds and the feasibility of appropriateness for in vivo testing removed six further compounds (ouabain; omeprazole; esomeprazole; Gleevec; D-LANA-14; and Tasigna. The three most promising compounds (17-DMAG; BGB324; and NCK-8 were further screened for in vivo activity in the guinea pig model of EBOV disease. Two of the compounds, BGB324 and NCK-8, showed some effect against lethal infection in vivo at the concentrations tested, which warrants further investigation. Further, these data add to the body of knowledge on the antiviral activities of multiple compounds against EBOV and indicate that the scientific community should invest more effort into the development of novel and specific antiviral compounds to treat Ebola virus disease.

  1. SYNTHESIS AND CHARACTERIZATION OF NEW INTERMETALLIC COMPOUNDS

    Energy Technology Data Exchange (ETDEWEB)

    Professor Monica Sorescu

    2003-05-07

    This six-month work is focused mainly on the properties of novel magnetic intermetallics. In the first project, we synthesized several 2:17 intermetallic compounds, namely Nd{sub 2}Fe{sub 15}Si{sub 2}, Nd{sub 2}Fe{sub 15}Al{sub 2}2, Nd{sub 2}Fe{sub 15}SiAl and Nd{sub 2}Fe{sub 15}SiMn, as well as several 1:12 intermetallic compounds, such as NdFe{sub 10}Si{sub 2}, NdFe{sub 10}Al{sub 2}, NdFe{sub 10}SiAl and NdFe{sub 10}MnAl. In the second project, seven compositions of Nd{sub x}Fe{sub 100-x-y}B{sub y} ribbons were prepared by a melt spinning method with Nd and B content increasing from 7.3 and 3.6 to 11 and 6, respectively. The alloys were annealed under optimized conditions to obtain a composite material consisting of the hard magnetic Nd{sub 2}Fe{sub 14}B and soft magnetic {alpha}-Fe phases, typical of a spring magnet structure. In the third project, intermetallic compounds of the type Zr{sub 1}Cr{sub 1}Fe{sub 1}T{sub 0.8} with T=Al, Co and Fe were subjected to hydrogenation. In the fourth project, we performed three crucial experiments. In the first experiment, we subjected a mixture of Fe{sub 3}O{sub 4} and Fe(80-20 wt%) to mechanochemical activation by high-energy ball milling, for time periods ranging from 0.5 to 14 hours. In the second experiment, we ball-milled Fe{sub 3}O{sub 4}:Co{sup 2+} (x=0.1) for time intervals between 2.5 and 17.5 hours. Finally, we exposed a mixture of Fe{sub 3}O{sub 4} and Co(80-20 wt%) to mechanochemical activation for time periods ranging from 0.5 to 10 hours. In all cases, the structural and magnetic properties of the systems involved were elucidated by X-ray diffraction (XRD), Moessbauer spectroscopy and hysteresis loop measurements. The four projects resulted in four papers, which are currently being considered for publication in Intermetallics, IEEE Transactions on Magnetics, Journal of Materials Science Letters and Journal of Materials Science. The contributions reveal for the first time in literature the effect of

  2. Simulations of charge transport in organic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Vehoff, Thorsten

    2010-05-05

    We study the charge transport properties of organic liquid crystals, i.e. hexabenzocoronene and carbazole macrocycle, and single crystals, i.e. rubrene, indolocarbazole and benzothiophene derivatives (BTBT, BBBT). The aim is to find structure-property relationships linking the chemical structure as well as the morphology with the bulk charge carrier mobility of the compounds. To this end, molecular dynamics (MD) simulations are performed yielding realistic equilibrated morphologies. Partial charges and molecular orbitals are calculated based on single molecules in vacuum using quantum chemical methods. The molecular orbitals are then mapped onto the molecular positions and orientations, which allows calculation of the transfer integrals between nearest neighbors using the molecular orbital overlap method. Thus we obtain realistic transfer integral distributions and their autocorrelations. In case of organic crystals the differences between two descriptions of charge transport, namely semi-classical dynamics (SCD) in the small polaron limit and kinetic Monte Carlo (KMC) based on Marcus rates, are studied. The liquid crystals are investigated solely in the hopping limit. To simulate the charge dynamics using KMC, the centers of mass of the molecules are mapped onto lattice sites and the transfer integrals are used to compute the hopping rates. In the small polaron limit, where the electronic wave function is spread over a limited number of neighboring molecules, the Schroedinger equation is solved numerically using a semi-classical approach. The carbazole macrocycles form columnar structures arranged on a hexagonal lattice with side chains facing inwards, so columns can closely approach each other allowing inter-columnar and thus three-dimensional transport. We are able to show that, on the time-scales of charge transport, static disorder due to slow side chain motions is the main factor determining the mobility. The high mobility of rubrene is explained by two main

  3. X-ray targeted bond or compound destruction

    Energy Technology Data Exchange (ETDEWEB)

    Pravica, Sr., Michael G.

    2016-11-01

    This document provides methods, systems, and devices for inducing a decomposition reaction by directing x-rays towards a location including a particular compound. The x-rays can have an irradiation energy that corresponds to a bond distance of a bond in the particular compound in order to break that bond and induce a decomposition of that particular compound. In some cases, the particular compound is a hazardous substance or part of a hazardous substance. In some cases, the particular compound is delivered to a desired location in an organism and x-rays induce a decomposition reaction that creates a therapeutic substance (e.g., a toxin that kills cancer cells) in the location of the organism. In some cases, the particular compound decomposes to produce a reactant in a reactor apparatus (e.g., fuel cell or semiconductor fabricator).

  4. Data mined ionic substitutions for the discovery of new compounds.

    Science.gov (United States)

    Hautier, Geoffroy; Fischer, Chris; Ehrlacher, Virginie; Jain, Anubhav; Ceder, Gerbrand

    2011-01-17

    The existence of new compounds is often postulated by solid state chemists by replacing an ion in the crystal structure of a known compound by a chemically similar ion. In this work, we present how this new compound discovery process through ionic substitutions can be formulated in a mathematical framework. We propose a probabilistic model assessing the likelihood for ionic species to substitute for each other while retaining the crystal structure. This model is trained on an experimental database of crystal structures, and can be used to quantitatively suggest novel compounds and their structures. The predictive power of the model is demonstrated using cross-validation on quaternary ionic compounds. The different substitution rules embedded in the model are analyzed and compared to some of the traditional rules used by solid state chemists to propose new compounds (e.g., ionic size).

  5. A class of CTRWs: Compound fractional Poisson processes

    CERN Document Server

    Scalas, Enrico

    2011-01-01

    This chapter is an attempt to present a mathematical theory of compound fractional Poisson processes. The chapter begins with the characterization of a well-known L\\'evy process: The compound Poisson process. The semi-Markov extension of the compound Poisson process naturally leads to the compound fractional Poisson process, where the Poisson counting process is replaced by the Mittag-Leffler counting process also known as fractional Poisson process. This process is no longer Markovian and L\\'evy. However, several analytical results are available and some of them are discussed here. The functional limit of the compound Poisson process is an $\\alpha$-stable L\\'evy process, whereas in the case of the compound fractional Poisson process, one gets an $\\alpha$-stable L\\'evy process subordinated to the fractional Poisson process.

  6. Photocytotoxic pheophorbide-related compounds from Aglaonema simplex.

    Science.gov (United States)

    Chee, Chin-Fei; Lee, Hong Boon; Ong, Hean Chooi; Ho, Anthony Siong-Hock

    2005-12-01

    In our screening program for new photosensitizers from the Malaysian biodiversity, we found five pheophorbide-related compounds from the leaves and stems of Aglaonema simplex. Detailed spectroscopic analyses showed that compounds 1-3 and 5 are pheophorbide and hydroxy pheophorbide derivatives of chlorophyll a and b. Compound 4, identified as 15(1)-hydroxypurpurin-7-lactone ethyl methyl diester, was isolated for the first time from the Araceae family. An MTT-based short-term survival assay showed that all five compounds exhibit moderate-to-strong photocytotoxic activities towards human leukemia (HL60) and two oral squamous carcinoma cell lines (HSC-2 and HSC-3). Compounds 4 and 5 showed the strongest photocytotoxicities, with IC(50) values of 0.30-0.41 muM (Table 2). Compounds 1-3 with Et chains at C(17(3)) were less photocytotoxic than the parent pheophorbide a (5).

  7. Electrodeposition of alloys or compounds in molten salts and applications

    Directory of Open Access Journals (Sweden)

    Taxil P.

    2003-01-01

    Full Text Available This article deals with the different modes of preparation of alloys or intermetallic compounds using the electrodeposition in molten salts, more particularly molten alkali fluorides. The interest in this process is to obtain new materials for high technology, particularly the compounds of reactive components such as actinides, rare earth and refractory metals. Two ways of preparation are considered: (i electrocoating of the more reactive metal on a cathode made of the noble one and reaction between the two metals in contact, and (ii electrocoating on an inert cathode of the intermetallic compound by coreduction of the ions of each elements. The kinetic is controlled by the reaction at the electrolyte interface. A wide bibliographic survey on the preparation of various compounds (intermetallic compounds, borides, carbides… is given and a special attention is paid to the own experience of the authors in the preparation of these compounds and interpretation of their results.

  8. Can volatile organic compounds be markers of sea salt?

    Science.gov (United States)

    Silva, Isabel; Coimbra, Manuel A; Barros, António S; Marriott, Philip J; Rocha, Sílvia M

    2015-02-15

    Sea salt is a handmade food product that is obtained by evaporation of seawater in saltpans. During the crystallisation process, organic compounds from surroundings can be incorporated into sea salt crystals. The aim of this study is to search for potential volatile markers of sea salt. Thus, sea salts from seven north-east Atlantic Ocean locations (France, Portugal, Continental Spain, Canary Islands, and Cape Verde) were analysed by headspace solid-phase microextraction combined with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. A total of 165 compounds were detected, ranging from 32 to 71 compounds per salt. The volatile composition revealed the variability and individuality of each salt, and a set of ten compounds were detected in all samples. From these, seven are carotenoid-derived compounds that can be associated with the typical natural surroundings of ocean hypersaline environment. These ten compounds are proposed as potential volatile markers of sea salt.

  9. Phytotherapic compounds: the consumer-pharmacist relationship.

    Science.gov (United States)

    Bacchini, Marco; Cuzzolin, Laura; Camerlengo, Thomas; Velo, Giampaolo; Benoni, Giuseppina

    2008-01-01

    Pharmacists play an important role in providing information about natural products and in preventing risks related to these substances, particularly with respect to interactions with conventional drugs. For these reasons, a survey was specifically designed to investigate the quality of self-care counselling by pharmacists on phytotherapy. Twenty-three pharmacy stores took part in the project. Face-to-face interviews, using a pre-structured questionnaire, were undertaken by trained pharmacists to consumers buying a herbal product. The questionnaire included socio-demographic data and 17 items designed to elicit information regarding the reason of consumption, product knowledge, relationship/communication with healthcare providers, level of satisfaction, concurrent drug use and adverse reactions. The collection of interviews started in November 2006 until April 2007. From the analysis of 1420 questionnaires, it is evident that herbal use is increasing in Italy: 12% of our interviewees were buying a herbal product for the first time. The present survey highlights the favourable perception of efficacy of phytotherapic compounds by the pharmacy's consumers, who consider this healthcare modality to be an important and effective way to promote health/wellness and disease management as well as being safer overall than conventional drugs. Moreover, findings from this study demonstrate that pharmacists are more likely to answer correctly about the uses of herbal medicines than about drug interactions, adverse drug effects and cautions about these products.

  10. FIELD SCREENING FOR HALOGENATED VOLATILE ORGANIC COMPOUNDS

    Energy Technology Data Exchange (ETDEWEB)

    John F. Schabron; Joseph F. Rovani Jr.; Theresa M. Bomstad

    2002-06-01

    Western Research Institute (WRI) initiated exploratory work towards the development of new field screening methodology and a test kit to measure halogenated volatile organic compounds (VOCs) in the field. Heated diode and corona discharge sensors are commonly used to detect leaks of refrigerants from air conditioners, freezers, and refrigerators. They are both selective to the presence of carbon-halogen bonds. Commercially available heated diode and corona discharge leak detectors were procured and evaluated for halogenated VOC response. The units were modified to provide a digital readout of signal related to VOC concentration. Sensor response was evaluated with carbon tetrachloride and tetrachloroethylene (perchloroethylene, PCE), which represent halogenated VOCs with and without double bonds. The response characteristics were determined for the VOCs directly in headspace in Tedlar bag containers. Quantitation limits in air were estimated. Potential interferences from volatile hydrocarbons, such as toluene and heptane, were evaluated. The effect of humidity was studied also. The performance of the new devices was evaluated in the laboratory by spiking soil samples and monitoring headspace for halogenated VOCs. A draft concept of the steps for a new analytical method was outlined. The results of the first year effort show that both devices show potential utility for future analytical method development work towards the goal of developing a portable test kit for screening halogenated VOCs in the field.

  11. Cometary micrometeorites and input of prebiotic compounds

    Directory of Open Access Journals (Sweden)

    Engrand C.

    2014-02-01

    Full Text Available The apparition of life on the early Earth was probably favored by inputs of extraterrestrial matter brought by carbonaceous chondrite-like objects or cometary material. Interplanetary dust collected nowadays on Earth is related to carbonaceous chondrites and to cometary material. They contain in particular at least a few percent of organic matter, organic compounds (amino-acids, PAHs,…, hydrous silicates, and could have largely contributed to the budget of prebiotic matter on Earth, about 4 Ga ago. A new population of cometary dust was recently discovered in the Concordia Antarctic micrometeorite collection. These “Ultracarbonaceous Antarctic Micrometeorites” (UCAMMs are dominated by deuterium-rich and nitrogen-rich organic matter. They seem related to the “CHON” grains identified in the comet Halley in 1986. Although rare in the micrometeorites flux (<5% of the micrometeorites, UCAMMs could have significantly contributed to the input of prebiotic matter. Their content in soluble organic matter is currently under study.

  12. Volatile organic compound remedial action project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-12-01

    This Environmental Assessment (EA) reviews a proposed project that is planned to reduce the levels of volatile organic compound (VOC) contaminants present in the Mound domestic water supply. The potable and industrial process water supply for Mound is presently obtained from a shallow aquifer via on-site production wells. The present levels of VOCs in the water supply drawn from the on-site wells are below the maximum contaminant levels (MCLs) permissible for drinking water under Safe Drinking Water Act (SDWA; 40 CFR 141); however, Mound has determined that remedial measures should be taken to further reduce the VOC levels. The proposed project action is the reduction of the VOC levels in the water supply using packed tower aeration (PTA). This document is intended to satisfy the requirements of the National Environmental Policy Act (NEPA) of 1969 and associated Council on Environmental Quality regulations (40 CFR parts 1500 through 1508) as implemented through U.S. Department of Energy (DOE) Order 5440.1D and supporting DOE NEPA Guidelines (52 FR 47662), as amended (54 FR 12474; 55 FR 37174), and as modified by the Secretary of Energy Notice (SEN) 15-90 and associated guidance. As required, this EA provides sufficient information on the probable environmental impacts of the proposed action and alternatives to support a DOE decision either to prepare an Environmental Impact Statement (EIS) or issue a Finding of No Significant Impact (FONSI).

  13. Processing of Complex Compound Semiconductors in Space

    Science.gov (United States)

    Bachmann, K.

    1985-01-01

    The purpose of this first year ground based research effort was to develop growth and characterization facilities for bulk single crystals of compound semiconductor alloys. As a system of 2-6 alloy crystal growth, C sub x Mn sub (1-x)Te was chosen since it has a relatively narrow solidus-liquidus separation serving as a suitable first model for zone melting and solution growth. Also, it allows, in principle, perfect lattice matching to Cd sub x Hg sub(1-x)Te that needs to be studied as a model for the investigation of heteroepitaxial growth from Te-solutions. A vertical zone melting furnace was built and used in the synthesis of Cd sub x Mn sub(1-x)Te from the elements and crystal growth in carbon coated fused silica crucibles of Bridgman growth geometry. Photoluminescence spectra of the crystals reveal band to band recombination at energies that agree with the reported literature data. In addition, deep luminescence is present at energies corresponding to proportional shifts from the 1.4 eV deep emission observed for bulk single crystals of CdTe.

  14. Thermoelectric properties of SnSe compound

    Energy Technology Data Exchange (ETDEWEB)

    Guan, Xinhong [State Key Laboratory of Information Photonics and Optical Communications, Ministry of Education, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876 (China); Lu, Pengfei, E-mail: photon@bupt.edu.cn [State Key Laboratory of Information Photonics and Optical Communications, Ministry of Education, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876 (China); Wu, Liyuan; Han, Lihong [State Key Laboratory of Information Photonics and Optical Communications, Ministry of Education, Beijing University of Posts and Telecommunications, P.O. Box 72, Beijing 100876 (China); Liu, Gang [School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876 (China); Song, Yuxin [State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050 (China); Wang, Shumin [State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050 (China); Photonics Laboratory, Department of Microtechnology and Nanoscience, Chalmers University of Technology, 41296 Gothenburg (Sweden)

    2015-09-15

    Highlights: • The electronic and thermoelectric properties of SnSe bulk material are studied. • The ZT can reach as high as 1.87 along yy and 1.6 along zz direction at 800k. • SnSe is an indirect-band material, and SOC has little effect on the band structure. • The high ZT can be attributed to the intrinsically ultralow thermal conductivity. - Abstract: A first-principles study and Boltzmann transport theory have been performed to evaluate the electronic structure and thermoelectric properties of SnSe compound. The energy band structure and density of states are studied in detail. The electronic transport coefficients are then calculated as a function of chemical potential or temperature within the assumption of the constant relaxation time. The figure of merit ZT is obtained with the use of calculated thermoelectric properties and can reach as high as 1.87 along yy and 1.6 along zz direction at 800 K. Our theoretical result agrees well with previous experimental data.

  15. Environmental risk management for pharmaceutical compounds

    Energy Technology Data Exchange (ETDEWEB)

    Voulvoulis, N. [Imperial College London (United Kingdom)

    2004-09-15

    Pharmaceuticals are a highly variable group of organic compounds with the potential to cause harm to aquatic ecosystems and human health. Thousands of tones of pharmacologically active substances are used annually but surprisingly little is known about their ultimate fate in the environment. The data collected to date, rarely provide information on the processes that determine their environmental fate and although they receive considerable pharmacological and clinical testing during development, knowledge of their ecotoxicity is poor. One major concern is that antibiotics found in sewage effluent may cause increased resistance amongst natural bacterial populations. The debate over risks associated with chemicals in the environment represents more than just another disagreement in the scientific community. It has opened the door to a new way of thinking about the onset of uninherited diseases, the nature of scientific investigation, and the role of scientific knowledge in the policymaking process. For example, research evidence on endocrine disruption collected over the last few years has changed dramatically the way we think about chemical risks. In part, this change has also been attributed to the precautionary principle, as a new approach to environmental policy forged in Europe. The term ''precautionary approach'' declares an obligation to control the dangerous substances even before a definitive causal link had been established between the chemicals and health or environmental effects, and represents a radical departure from traditional approaches to risk assessment and particularly risk management, which includes an integration of the assessment, communication and mitigation of risks.

  16. Compound specific isotope analysis of organophosphorus pesticides.

    Science.gov (United States)

    Wu, Langping; Yao, Jun; Trebse, Polonca; Zhang, Ning; Richnow, Hans H

    2014-09-01

    Compound-specific isotope analysis (CSIA) has been established as a tool to study the environmental fate of a wide range of contaminants. In this study, CSIA was developed to analyse the stable carbon isotope signatures of the widely used organophosphorus pesticides: dichlorvos, omethoate and dimethoate. The linearity of the GC-C-IRMS system was tested for target pesticides and led to an acceptable isotope composition within the uncertainty of the instrument. In order to assess the accuracy of the developed method, the effect of the evaporation procedure on measured carbon isotope composition (δ(13)C) values was studied and showed that concentration by evaporation of solvents had no significant isotope effect. The CSIA was then applied to investigate isotope fractionation of the hydrolysis and photolysis of selected pesticides. The carbon isotope fractionation of tested pesticides was quantified by the Rayleigh model, which revealed a bulk enrichment factor (ε) of -0.2±0.1‰ for hydrolysis of dichlorvos, -1.0±0.1‰ and -3.7±1.1‰ for hydrolysis and photolysis of dimethoate respectively. This study is a first step towards the application of CSIA to trace the transport and degradation of organophosphorus pesticides in the environment.

  17. Screening of Compounds against Gardnerella vaginalis Biofilms.

    Directory of Open Access Journals (Sweden)

    Cornelia Gottschick

    Full Text Available Bacterial vaginosis (BV is a common infection in reproductive age woman and is characterized by dysbiosis of the healthy vaginal flora which is dominated by Lactobacilli, followed by growth of bacteria like Gardnerella vaginalis. The ability of G. vaginalis to form biofilms contributes to the high rates of recurrence that are typical for BV and which unfortunately make repeated antibiotic therapy inevitable. Here we developed a biofilm model for G. vaginalis and screened a large spectrum of compounds for their ability to prevent biofilm formation and to resolve an existing G. vaginalis biofilm. The antibiotics metronidazole and tobramycin were highly effective in preventing biofilm formation, but had no effect on an established biofilm. The application of the amphoteric tenside sodium cocoamphoacetate (SCAA led to disintegration of existing biofilms, reducing biomass by 51% and viability by 61% and it was able to increase the effect of metronidazole by 40% (biomass and 61% (viability. Our data show that attacking the biofilm and the bacterial cells by the combination of an amphoteric tenside with the antibiotic metronidazole might be a useful strategy against BV.

  18. Internal combustion engine with compound air compression

    Energy Technology Data Exchange (ETDEWEB)

    Paul, M.A.; Paul, A.

    1991-10-15

    This patent describes an internal combustion engine in combination with a compound air compression system. It comprises: a reciprocator with at least one cylinder, at least one piston reciprocal in the cylinder and a combustion chamber formed in substantial part by portions of the piston and cylinder, the reciprocator having a drive shaft; a rotary compressor having a drive shaft mechanically coupled to the drive shaft of the reciprocator, the rotary compressor having a Wankel-type, three-lobe, epitrochiodal configuration sides having a conduit conjected to the reciprocator for supplying compressed air to the reciprocator; a turbocharged with a gas turbine and a turbocompressor, the turbocompressor having an air conduit connected to the expander side of the rotary compressor; and a bypass conduit with a valve means connecting the turbocharger to the reciprocator for supplying compressed air directly to the reciprocator wherein the drive shaft of the reciprocator and the drive shaft of the compressor have connecting means for transmitting mechanical energy to the reciprocator at mid to high operating speeds of the engine when the turbocharge supplies compressed air to the rotary compressor and, at least in part, drives the rotary compressor.

  19. Electrochemical oxidation of perfluorinated compounds in water.

    Science.gov (United States)

    Niu, Junfeng; Li, Yang; Shang, Enxiang; Xu, Zesheng; Liu, Jinzi

    2016-03-01

    Perfluorinated compounds (PFCs) are persistent and refractory organic pollutants that have been detected in various environmental matrices and municipal wastewater. Electrochemical oxidation (EO) is a promising remediation technique for wastewater contaminated with PFCs. A number of recent studies have demonstrated that the "non-active" anodes, including boron-doped diamond, tin oxide, and lead dioxide, are effective in PFCs elimination in wastewater due to their high oxygen evolution potential. Many researchers have conducted experiments to investigate the optimal conditions (i.e., potential, current density, pH value, plate distance, initial PFCs concentration, electrolyte, and other factors) for PFCs elimination to obtain the maximal elimination efficiency and current efficiency. The EO mechanism and pathways of PFCs have been clearly elucidated, which undergo electron transfer, Kolbe decarboxylation or desulfonation, hydrolysis, and radical reaction. In addition, the safety evaluation and energy consumption evaluation of the EO technology have also been summarized to decrease toxic ion release from electrode and reduce the cost of this technique. Although the ultrasonication and hydrothermal techniques combined with the EO process can improve the removal efficiency and current efficiency significantly, these coupled techniques have not been commercialized and applied in industrial wastewater treatment. Finally, key challenges facing EO technology are listed and the directions for further research are pointed out (such as combination with other techniques, treatment for natural waters contaminated by low levels of PFCs, and reactor design).

  20. Design and Synthesis of Novel Antileishmanial Compounds

    Directory of Open Access Journals (Sweden)

    Melanie Loedige

    2015-01-01

    Full Text Available According to the WHO, infectious diseases, and in particular neglected tropical diseases in poor developing countries, still play a significant role in a vast number of deaths reported worldwide. Among them, leishmaniasis occurs as a complex and clinically diverse illness caused by protozoan Leishmania species which are transmitted through the bite of sandflies. They develop through a complex life cycle, from promastigotes in sandflies to amastigotes in humans. The severity of disease is determined by the type of infecting Leishmania species and also depends strongly on whether the parasite infection leads to a systemic involvement or not. Since the sensitivity towards diverse medicaments highly differs among the Leishmania species, it is advantageous to treat leishmaniasis with species-specific drugs. Towards this goal we report a synthetic methodology and characterization of novel small molecular agents active against both forms of L. major. This synthetic approach allows for rapid access to new active antileishmanial drug templates and their first derivatives in moderate to very good yields. Although the compounds reported here are bioactive, the detailed biological results are part of a more comprehensive study and will be reported separately by our collaborators.

  1. CARBOXYLESTERASES IN ENANTIOSELECTIVE SYNTHESIS OF ORGANIC COMPOUNDS

    Directory of Open Access Journals (Sweden)

    E. A. Shesterenko

    2013-02-01

    Full Text Available The classification, structure, and mechanism of catalytic action of carboxylesterase of different origin are presented in the review. The prospects of carboxylesterases application for metabolism and both several drugs and prodrugs activation investigation in vitro are shown. The enzyme usage as biocatalyst of stereoselective hydrolysis and synthesis of a wide range of acyclic, carbocyclic and heterocyclic compounds — esters are also urgent. It was established that enantiomers obtainable with the help of carboxylesterase are characterized by high chemical yields and optical purity; immobilization on different supports stabilizes the enzyme and allows the repeated usage of obtained biocatalysts. The own studies conducted and the enzymatic hydrolysis features of news 3-acylhydroxy-1,4-benzodiasepin-2-ones — potential anxiolytic and hypnotic means, with a help of pig liver microsomal fraction carboxylesterase have been established. For the first time the enantioselective hydrolysis of 3-acetoxy-7-bromo-1-methyl-5-phenyl-1,2-dihydro-3H-1,4-benzdiazepine-2-one was accomplished using free and immobilized in phyllophorine and alginate, stabilized by Ca2+ microsomal fraction. The S-enantiomer of substrate was isolated, which suggests the increased specificity of pig liver microsomal fraction carboxylesterase to its R-enantiomer.

  2. Organic compounds in concrete from demolition works.

    Science.gov (United States)

    Van Praagh, M; Modin, H; Trygg, J

    2015-11-01

    This study aims to verify the effect of physically removing the outer surface of contaminated concrete on total contents and on potential mobility of pollutants by means of leaching tests. Reclaimed concrete from 3 industrial sites in Sweden were included: A tar impregnated military storage, a military tar track-depot, as well as concrete constructions used for disposing of pesticide production surplus and residues. Solid materials and leachates from batch and column leaching tests were analysed for metals, Cl, F, SO4, DOC and contents of suspected organic compounds (polycyclic aromatic hydrocarbons, PAH, and pesticides/substances for pesticide production such as phenoxy acids, chlorophenols and chlorocresols, respectively). In case of PAH contaminated concrete, results indicate that removing 1 or 5 mm of the surface lead to total concentrations below the Swedish guidelines for recycling of aggregates and soil in groundwork constructions. 3 out of 4 concrete samples contaminated with pesticides fulfilled Swedish guidelines for contaminated soil. Results from batch and column leaching tests indicated, however, that concentrations above environmental quality standards for certain PAH and phenoxy acids, respectively, might occur at site when the crushed concrete is recycled in groundwork constructions. As leaching tests engaged in the study deviated from leaching test standards with a limited number of samples, the potential impact of the leaching tests' equipment on measured PAH and pesticide leachate concentrations has to be evaluated in future work.

  3. Biological activity of acetylated phenolic compounds.

    Science.gov (United States)

    Fragopoulou, Elizabeth; Nomikos, Tzortzis; Karantonis, Haralabos C; Apostolakis, Constantinos; Pliakis, Emmanuel; Samiotaki, Martina; Panayotou, George; Antonopoulou, Smaragdi

    2007-01-10

    In recent years an effort has been made to isolate and identify biologically active compounds that are included in the Mediterranean diet. The existence of naturally occurring acetylated phenolics, as well as studies with synthetic ones, provide evidence that acetyl groups could be correlated with their biological activity. Platelet activating factor (PAF) is implicated in atherosclerosis, whereas its inhibitors seem to play a protective role against cardiovascular disease. The aim of this study was to examine the biological activity of resveratrol and tyrosol and their acetylated derivatives as inhibitors of PAF-induced washed rabbit platelet aggregation. Acetylation of resveratrol and tyrosol was performed, and separation was achieved by HPLC. Acetylated derivatives were identified by negative mass spectrometry. The data showed that tyrosol and its monoacetylated derivatives act as PAF inhibitors, whereas diacetylated derivatives induce platelet aggregation. Resveratrol and its mono- and triacetylated derivatives exert similar inhibitory activity, whereas the diacetylated ones are more potent inhibitors. In conclusion, acetylated phenolics exert the same or even higher antithrombotic activity compared to the biological activity of the initial one.

  4. Phenolic compounds: their journey after intake.

    Science.gov (United States)

    Velderrain-Rodríguez, G R; Palafox-Carlos, H; Wall-Medrano, A; Ayala-Zavala, J F; Chen, C-Y O; Robles-Sánchez, M; Astiazaran-García, H; Alvarez-Parrilla, E; González-Aguilar, G A

    2014-02-01

    Plant foods are rich in phenolic compounds (PCs) that display multifaceted bioactions in health promotion and disease prevention. To exert their bioactivity, they must be delivered to and absorbed in the gastrointestinal (GI) tract, transported in circulation, and reach the target tissues. During the journey from ingestion to target tissues and final excretion, PCs are subjected to modifications by many factors during their absorption, deposition, metabolism and excretion (ADME) and consequently their bioefficacy may be modified. Consistent with all nutrients in foods, PCs must first be released from the food matrix through mechanical, chemical, and enzymatic forces to facilitate absorption along the GI tract, particularly in the upper small intestine section. Further, glycosylation of PCs directs the route of their absorption with glycones being transported through active transportation and aglycones through passive diffusion. After enteral absorption, the majority of PCs are extensively transformed by the detoxification system in enterocytes and liver for excretion in bile, feces, and urine. The journey of PCs from consumption to excretion appears to be comparable to many synthetic medications, but with some dissimilarities in their fate and bioactivity after phase I and II metabolism. The overall bioavailability of PCs is determined mainly by chemical characteristics, bioaccessibility, and ADME. In this review, factors accounting for variation in PCs bioavailability are discussed because this information is crucial for validation of the health benefits of PCs and their mechanism of action.

  5. Phenolic compounds among the bioactive molecules in Ginkgo biloba L.

    OpenAIRE

    Pereira, Eliana; Barros, Lillian; Santos-Buelga, Celestino; Isabel C. F. R. Ferreira

    2015-01-01

    The interest for natural antioxidants has been increasing over the years. Phenolic compounds comprise a very large group of biologically active molecules, being appreciated for their beneficial effects on health (physiologically active compounds with anti-allergic, antiatherogenic, antimicrobial, antithrombotic, anti-inflammatory, antioxidant, cardioprotective and vasodilatory effects) [1-3]. The aim of the present study was to evaluate the phenolic compounds of Ginkgo biloba L...

  6. Compound fuzzy model for thermal performance of refrigeration compressors

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The fuzzy method is introduced to the calculation of thermal performance of refrigeration compressors. A compound model combining classical thermodynamic theory and fuzzy theory is presented and compared with a simple fuzzy model without classical thermodynamic fundamentals. Case study of refrigeration compressors shows that the compound fuzzy model and the simple fuzzy model are both more efficient than the classical thermodynamic method. However, the compound fuzzy model is of better precision and adaptability.

  7. Phenolic characterization of Northeast Portuguese propolis: usual and unusual compounds

    OpenAIRE

    Falcão, Soraia; Vilas-Boas, Miguel; Estevinho, Leticia M.; Barros, Cristina; Domingues, M. R. M.; Cardoso, Susana M.

    2010-01-01

    In this study, an ethanolic extract from Portuguese propolis was prepared, fractionated by highperformance liquid chromatography, and the identification of the phenolic compounds was done by electrospray mass spectrometry in the negative mode. This technical approach allowed the identification of 37 phenolic compounds, which included not only the typical phenolic acids and flavonoids found in propolis from temperate zones but also several compounds in which its occurre...

  8. Health promoting and sensory properties of phenolic compounds in food

    OpenAIRE

    Lívia de Lacerda de Oliveira; Mariana Veras de Carvalho; Lauro Melo

    2014-01-01

    Phenolic compounds have been extensively studied in recent years. The presence of these compounds in various foods has been associated with sensory and health promoting properties. These products from the secondary metabolism of plants act as defense mechanisms against environmental stress and attack by other organisms. They are divided into different classes according to their chemical structures. The objective of this study was to describe the different classes of phenolic compounds, the ma...

  9. OCCURRENCE & CHEMISTRY OF ORGANIC COMPOUNDS IN HANFORD SITE WASTE TANKS

    Energy Technology Data Exchange (ETDEWEB)

    STOCK, L.M.; MEACHAM, J.E.

    2004-07-29

    Volatile and semivolatile organic compounds continuously evolve from the waste tanks at the Hanford Site. Some are identical to the compounds originally transferred to tanks and others are formed through interdependent chemical and radiolytic reactions. This document provides a technical basis for understanding the chemical consequences of long term storage, sluicing, the addition of chemicals, and the prediction of other organic compounds that may be present in the wastes.

  10. Effective Components of Chinese Herbal Compound Decoction and Maillard Reaction

    Institute of Scientific and Technical Information of China (English)

    曹治云; 陈旭征; 张恩达; 杜建

    2009-01-01

    This paper intends to explore the color changes considered to be Maillard reaction during the process of Chinese herbal medicine.The Maillard reaction products(MRPs) are often in substantial proportions of Chinese herbal compound decoctions but their effects are often neglected.By considering the effects of MRPs in studies of effective components on Chinese herbal compounds,a new perspective is established in future researches of Chinese herbal compound decoctions.

  11. Triterpenes and phenolic compounds in apple fruit (Malus domestica Borkh.)

    OpenAIRE

    Lv, Yanrong

    2016-01-01

    Apple (Malus × domestica Borkh.), a popular and widely cultivated fruit world-wide, contains bioactive triterpenes and phenolic compounds with potentially valuable pharmacological functions. This thesis investigated the effects of pre-harvest and postharvest factors on concentrations of these bioactive compounds in apples. It also studied the effect of ozone treatment, before or during storage, combined with cold storage on triterpene and phenolic compound concentrations in apples and the ant...

  12. Antibacterial and Antiyeast Compounds from Marine-Derived Bacteria

    Directory of Open Access Journals (Sweden)

    Muhammad Abdul Mojid Mondol

    2014-05-01

    Full Text Available Two new (2 and 3 and a known (1 antimicrobial compounds were isolated from EtOAc extracts of two marine bacterial strains cultured in modified Bennett’s broth medium. The structures of these compounds were determined based on the analysis of nuclear magnetic resonance (NMR, high resolution mass spectroscopy (HRMS, literature data review and considering biogenesis. All the compounds (1–3 demonstrated in vitro antimicrobial activities against selected pathogenic strains.

  13. Algorithm for Automatic Generation of Curved and Compound Twills

    Institute of Scientific and Technical Information of China (English)

    WANG Mei-zhen; WANG Fu-mei; WANG Shan-yuan

    2005-01-01

    A new arithmetic using matrix left-shift functions for the quicker generation of curved and compound twills is introduced in this paper. A matrix model for the generation of regular, curved and compound twill structures is established and its computing simulation realization are elaborated. Examples of the algorithm applying in the simulation and the automatic generation of curved and compound twills in fabric CAD are obtained.

  14. Spectrophotometric Assays of Major Compounds Extracted from Algae.

    Science.gov (United States)

    Connan, Solène

    2015-01-01

    This chapter describes spectrophotometric assays of major compounds extracted from microalgae and macroalgae, i.e., proteins, carbohydrates, pigments (chlorophylls, carotenoids, and phycobiliproteins) and phenolic compounds. In contrast to other specific analytical techniques, such as high pressure liquid chromatography (HPLC) or mass spectrometry (MS), commonly applied to purified extracts to reveal more detailed composition and structure of algal compound families, these assays serve as a first assessment of the global contents of extracts.

  15. Compounds, compositions, pharmaceutical compositions, and methods of use

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, Gerald B.; Jin, Zhuang; Bates, Paula J.; Reyes-Reyes, Elsa Merit

    2016-11-15

    Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.

  16. Analysis of Japanese Compound Nouns using Collocational Information

    CERN Document Server

    Kobayashi, Y; Tanaka, H; Kobayasi, Yosiyuki; Takunaga, Takenobu; Tanaka, Hozumi

    1994-01-01

    Analyzing compound nouns is one of the crucial issues for natural language processing systems, in particular for those systems that aim at a wide coverage of domains. In this paper, we propose a method to analyze structures of Japanese compound nouns by using both word collocations statistics and a thesaurus. An experiment is conducted with 160,000 word collocations to analyze compound nouns of with an average length of 4.9 characters. The accuracy of this method is about 80%.

  17. An improved technique for isolating codominant compound microsatellite markers.

    Science.gov (United States)

    Lian, Chunlan L; Abdul Wadud, Md; Geng, Qifang; Shimatani, Kenichiro; Hogetsu, Taizo

    2006-07-01

    An approach for developing codominant polymorphic markers (compound microsatellite (SSR) markers), with substantial time and cost savings, is introduced in this paper. In this technique, fragments flanked by a compound SSR sequence at one end were amplified from the constructed DNA library using compound SSR primer (AC)6(AG)5 or (TC)6(AC)5 and an adaptor primer for the suppression-PCR. A locus-specific primer was designed from the sequence flanking the compound SSR. The primer pairs of the locus-specific and compound SSR primers were used as a compound SSR marker. Because only one locus-specific primer was needed for design of each marker and only a common compound SSR primer was needed as the fluorescence-labeled primer for analyzing all the compound SSR markers, this approach substantially reduced the cost of developing codominant markers and analyzing their polymorphism. We have demonstrated this technique for Dendropanax trifidus and easily developed 11 codominant markers with high polymorphism for D. trifidus. Use of the technique for successful isolation of codominant compound SSR markers for several other plant species is currently in progress.

  18. DAR Assisted Layer-by-Layer Assembly of Aromatic Compounds

    Institute of Scientific and Technical Information of China (English)

    姜思光; 陈晓东; 张莉; 刘鸣华

    2003-01-01

    A facile DAR (diphenylamine-4-diazonium-formaldehyde resin)assisted layer-by-layer (LbL) assembly of uitrathin organic film of aromatic compounds has been investigated. The muitilayer of pyrene or anthracene was fabricated through simple dipping of the glass slide into the mixed solution of DAR with the target compounds. In this method, DAR acted as an assistant compound to help the assembling of the aromatic compounds. Such a convenient deposition method not only reserves the advantages of the traditional LbL technique but also simplifies the technique and extends the effectiveness of LbL technique to small molecules without any charge.

  19. Photochemical transformations of diazocarbonyl compounds: expected and novel reactions

    Science.gov (United States)

    Galkina, O. S.; Rodina, L. L.

    2016-05-01

    Photochemical reactions of diazocarbonyl compounds are well positioned in synthetic practice as an efficient method for ring contraction and homologation of carboxylic acids and as a carbene generation method. However, interpretation of the observed transformations of diazo compounds in electronically excited states is incomplete and requires a careful study of the fine mechanisms of these processes specific to different excited states of diazo compounds resorting to modern methods of investigation, including laser technology. The review is devoted to analysis of new data in the chemistry of excited states of diazocarbonyl compounds. The bibliography includes 155 references.

  20. Triorganotin as a compound with potential reproductive toxicity in mammals

    Directory of Open Access Journals (Sweden)

    V.S. Delgado Filho

    2011-09-01

    Full Text Available Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.