WorldWideScience

Sample records for aya monograph colon

  1. Treatment of adolescents and young adults (AYA) with cancer in a multidisciplinary setting: on the way to a highly specialized AYA unit.

    Science.gov (United States)

    Bernig, T; Jahn, F; Witkowsky, S; Huehn, R; Hentschel, A; Kegel, T; Schmoll, H-J; Körholz, D

    2013-11-01

    Further survival improvements of adolescents and young adults (AYA) with cancer are clearly affected by biological characteristics of the malignancies and age-specific needs. Multidisciplinary teams drawing expertice from both pediatric and adult cancer teams as well as clinical trials are required to meet the age specific needs of AYA patients with cancer. In 2011, the first AYA unit was established at the University Hospital Halle (Saale), where patients with newly-diagnosed cancer aged 15-25 are treated interdisciplinary by pediatric and adult oncologists. The enrollment into pediatric or adult clinical trials is controlled by age 18. Over the last 2 years, 19 AYA with cancer have been treated at the unit; and, in turn patients and their relatives reflected a high satisfaction with the offered novel health care approach. In the scope of the future Comprehensive Cancer Center at the University Hospital Halle (Saale), a complete ward is planned for all admitted AYA up to 25 years with cancer. The patients will be treated by a tumor-specialized multidisciplinary team of adult or pediatric oncologists and oncological surgeons. Therefore, we intend to establish a special teaching curriculum for physicians, nurses and psychosocial health care staff. Rather than age, cancer biology of a malignancy, surveillance data of late side effects as well as the age-specific needs of AYA patients will be crucial for best treatment options. PMID:24166088

  2. Ruth Ayaß: Kommunikation und Geschlecht. Stuttgart: W. Kohlhammer Verlag 2008

    Directory of Open Access Journals (Sweden)

    Michaela Goll

    2009-03-01

    Full Text Available Ruth Ayaß gibt in der vorliegenden Einführung einen Überblick über den Forschungsstand und die wesentlichen Diskussionsstränge zum Thema Kommunikation und Geschlecht. Sie zeigt dabei, ob und wie sich männliche von weiblichen Gesprächstilen unterscheiden lassen und wie verschiedene Geschlechter erst interaktiv, nämlich durch kommunikative Prozesse, erzeugt werden. Der Band eignet sich hervorragend als Lehrbuch in soziologischen und sprachwissenschaftlichen Studiengängen, bietet aber auch für die konstruktivistische Genderforschung wichtige Anknüpfungspunkte.In this introductory text, Ruth Ayaß presents an overview of the state of research and the important issues on the topic of Communication and Gender (Kommunikation und Geschlecht. She thus shows if and how masculine and feminine speech styles can be differentiated and how different genders come into being through interaction, or more specifically, through communicative processes. The volume is excellently suited for use as a textbook in sociological and linguistic disciplines while also offering important points of departure for constructivist gender research.

  3. Counseling Techniques Monograph.

    Science.gov (United States)

    Woody, Robert H.; And Others

    This monograph is designed to provide technical materials for counselor trainees. Its purpose is to help fill the void of published technical accounts. The papers included are very personalized and void of research documentation. The format was directed at allowing professional counselor educators to share their own technical ideas. Included in…

  4. Professional Monograph Review

    Directory of Open Access Journals (Sweden)

    Mildeová Stanislava

    2008-10-01

    Full Text Available Title of the monograph: Systems Approach to Knowledge Modelling. Authors: dr. Ludmila Dömeová; dr. Milan Houška; dr. Martina Houšková Beránková. Cover designer: Olga Čermáková. Interior designer: Roman Kvasnička. Publisher: Graphical Studio Olga Čermáková, Czech Republic. Place: Hradec Králové, Czech Republic. Year of publication: 2008. Number of pages: 282. Recommended price of the book: 39.90 EUR. First edition. Reviewer : dr. Stanislava Mildeová; Department of Systems Analysis, Faculty of Informatics and Statistics, University of Economics, Prague.

  5. Professional Monograph Review

    OpenAIRE

    Mildeová Stanislava

    2008-01-01

    Title of the monograph: Systems Approach to Knowledge Modelling. Authors: dr. Ludmila Dömeová; dr. Milan Houška; dr. Martina Houšková Beránková. Cover designer: Olga Čermáková. Interior designer: Roman Kvasnička. Publisher: Graphical Studio Olga Čermáková, Czech Republic. Place: Hradec Králové, Czech Republic. Year of publication: 2008. Number of pages: 282. Recommended price of the book: 39.90 EUR. First edition. Reviewer : dr. Stanislava Mildeová; Department of Systems Analysis, Faculty of ...

  6. Biodiversity within the subfamily Alyssinae (Hymenoptera, Braconidae in the Natural Park Peñas de Aya (Spain

    Directory of Open Access Journals (Sweden)

    Francisco Javier Peris-Felipo

    2011-09-01

    Full Text Available Biodiversity within the subfamily Alyssinae (Hymenoptera, Braconidae in the Natural Park Peñas de Aya (Spain. The study of parasitoid Hymenoptera is of significance for the assessment of diversity in a given area because of their role in the regulation of insects populations. The present work analyses diversity within Alysiinae (Hymenoptera, Braconidae in the Forested Estate of Artikutza, located in the Natural Park Peñas de Aya, western Pyrenees, Spain. Collection of specimens was spread over two years and was carried out in two different habitats: mixed forest and beech forest. A total of 2,270 specimens, belonging to 22 separate genera, were captured. Subsequently, alpha, beta and gamma diversities were analysed, and the beech forest was proven to host greater diversity than the mixed forest. A sampling strategy was adopted for the analysis of Alysiinae phenology and its relationship with environmental climatic conditions; as a result, a direct relationship between phenology and temperature was attested.Biodiversidade na Alyssinae subfamília (Hymenoptera, Braconidae no Parque Natural Peñas de Aya (Espanha. O estudo dos himenópteros parasitóides é significativo para uma avaliação da diversidade em determinada área por causa do seu papel no controle das populações de insetos. O presente trabalho analisa a diversidade no taxon Alysiinae (Himenóptero, Braconidae na área de floresta de Artikutza, localizada no Parque Natural de Peñas de Aya, Pirinéus ocidentais, Espanha. A coleta de espécimes dividiu-se em dois anos e foi realizada em dois habitats diferentes: floresta mista e floresta de faias. No total, foram capturados 2.270 exemplares pertencentes a 22 gêneros distintos. Subsequentemente, as variedades alfa, beta e gama foram analisadas, comprovando-se que a floresta de faias apresenta uma diversidade maior que a floresta mista. Adotou-se a estratégia de amostra para análise da fenologia da Alysiinae e da sua relação com

  7. Biodiversity within the subfamily Alyssinae (Hymenoptera, Braconidae in the Natural Park Peñas de Aya (Spain

    Directory of Open Access Journals (Sweden)

    Francisco Javier Peris-Felipo

    2011-09-01

    Full Text Available Biodiversity within the subfamily Alyssinae (Hymenoptera, Braconidae in the Natural Park Peñas de Aya (Spain. The study of parasitoid Hymenoptera is of significance for the assessment of diversity in a given area because of their role in the regulation of insects populations. The present work analyses diversity within Alysiinae (Hymenoptera, Braconidae in the Forested Estate of Artikutza, located in the Natural Park Peñas de Aya, western Pyrenees, Spain. Collection of specimens was spread over two years and was carried out in two different habitats: mixed forest and beech forest. A total of 2,270 specimens, belonging to 22 separate genera, were captured. Subsequently, alpha, beta and gamma diversities were analysed, and the beech forest was proven to host greater diversity than the mixed forest. A sampling strategy was adopted for the analysis of Alysiinae phenology and its relationship with environmental climatic conditions; as a result, a direct relationship between phenology and temperature was attested.

  8. PROVIDING AFFORDABLE HIGHER EDUCATION TO RURAL GIRLS IN INDIAN PUNJAB: A CASE STUDY OF BABA AYA SINGH RIARKI COLLEGE

    Directory of Open Access Journals (Sweden)

    RANJIT SINGH GHUMAN

    2013-12-01

    Full Text Available The paper highlights a case study of a rural girls college located in a remote village of Gurdaspur district in Indian Punjab. The idea of this unique college was conceptualised by one Baba Aya Singh, a social and religious activist, from a village near the college way back in 1925. It was really a revolutionary idea because female education in India, particularly higher education, was a distant dream at that time. The college was, however, started with only 14 rural girls after about half-a-century when the great visionary Baba Aya Singh had a dream to educate the rural girls. Access to and affordability of higher education is the uniqueness of this college. The student has to pay only Rs. 5800 (about US $ 65 per annum, which includes both the tuition fee and boarding and lodging. It is equally significant to note that the entire expenses of the college are met by this and the produce of agricultural land of the college. The college does not take any outside help. The meritorious senior class students teach the junior class students. The college in its own humble, but significant, way made a revolutionary contribution to the education of poor rural girls who, otherwise, would not have dreamt of college education. Apart from, class-room teaching and bookish knowledge, the students are taught social, ethical and management skills in a most natural manner. The product of the college has proved to be the agents of change and rural transformation.

  9. Monograph of Coccinia (Cucurbitaceae

    Directory of Open Access Journals (Sweden)

    Norbert Holstein

    2015-08-01

    Full Text Available This monograph deals with all 95 names described in the Cucurbitaceae genus Coccinia and recognizes 25 species. Taxonomic novelties are Coccinia adoensis var. aurantiaca (C.Jeffrey Holstein, stat. nov., C. sessilifolia var. variifolia (A.Meeuse Holstein, stat. nov., and C. adoensis var. jeffreyana Holstein, var. nov. For the 25 species 3157 collections were examined, of which 2024 were georeferenced to produce distribution maps. All species are distributed in sub-Saharan Africa with one species, C. grandis, extending from Senegal in West Africa east to Indonesia and being naturalized on Pacific Islands, in Australia, the Caribbean, and South America. Coccinia species are dioecious creepers or climbers with simple or bifid tendrils that occupy a range of habitats from arid scrubland, woodlands to lowland rainforest and mist forest. The corolla of Coccinia species is sympetalous, usually pale yellow to orange, and 1 to 4.5 cm long. Pollination is by bees foraging for pollen or nectar. After pollination, the developing ovary often exhibits longitudinal mottling, which usually disappears during maturation. All species produce berries with a pericarp in reddish colors (orange-red through to scarlet red, hence the generic name. The globose to cylindrical fruits contain numerous grayish-beige flat to lenticular seeds. Chromosome numbers are 2n = 20, 24, and 22 + XX/XY. Many Coccinia species are used for food, either as roasted tubers, greens as spinach, or the fruits as vegetables. Medicinal value is established in C. grandis, of which leaves and sap are used against diabetes.

  10. Yersinia enterocolitica Monographic Study

    Directory of Open Access Journals (Sweden)

    Emil Tirziu

    2011-10-01

    Full Text Available Germs from Yersinia genus have a vast ecologic niche, being met at different domestic and wild animal species, but also in food, water and soil. The majority of yersinis live in the digestive tract of human and numerous animal species, especially rodents, but also in soil, plant debris, waters etc. Numerous species of Yersinia genus could produce characteristic infections in human, the main source of infections is represented by rodents and hematophagous insects or, more frequently, by water or contaminated food. In a 1999 study, Mead and coauthors established that the Yersinia enterocolitica prevalence in food, in USA, is around 90%. Foods of animal origin more frequently contaminated with Yersinia enterocolitica are: pork, poultry, beef and lamb meat, milk, ice-cream, sea fruits etc., among them pork meat and milk represents the sources of the most numerous toxi-infection outbreaks in human, in different world regions. Bacteria determine infections which interest the digestive tract in numerous animal species and human, with diarrhea, lymphadenitis, pneumonia and abortion are the most important symptoms. Yersinia enterocolitica enter the human body regularly by oral ingestion, and localize itself with predilection in the distal portion of the ileum and at the ileocaecal appendix and proximal colon level, were determine a terminal ileitis with lymphadenitis, acute enterocolitis, and secondary accompanied with nodosum erythema, poliartritis that could be complicated with septicemia, sometimes leading to death.

  11. Colon cancer

    Science.gov (United States)

    Colorectal cancer; Cancer - colon; Rectal cancer; Cancer - rectum; Adenocarcinoma - colon; Colon - adenocarcinoma ... often lead to a complete cure. Almost all colon cancers start in the lining of the colon and ...

  12. Determination of pathogens causing damping-off and their pathogenicity in tomato seedbeds in Ankara (Ayaş, Beypazarı and Nallıhan districts) province

    OpenAIRE

    AŞKIN, Ayşe; KATIRCIOĞLU, Y. Zekai

    2009-01-01

    This research was carried out for determination of pathogens causing damping-off and their pathogenicity in tomato seedbeds in Ankara province (Ayaş, Beypazarı and Nallıhan districts) in 2003. Two hundred eleven samples of tomato seedlings, thought to be infected with damping off were collected from 42 seedbeds. Fusarium spp., Pythium spp., Rhizoctonia solani, Alternaria spp. and Aspergillus spp. were isolated from all collected  tomato seddlings. Fusarium spp., Pythium spp., R. solani a...

  13. Unmet Support Service Needs and Health-Related Quality of Life among Adolescents and Young Adults with Cancer: The AYA HOPE Study

    Directory of Open Access Journals (Sweden)

    Ashley Wilder Smith

    2013-04-01

    Full Text Available Introduction: Cancer for adolescents and young adults (AYA differs from younger and older patients; AYA face medical challenges while navigating social and developmental transitions. Research suggests that these patients are under- or inadequately served by current support services, which may affect health-related quality of life (HRQOL.Methods: We examined unmet service needs and HRQOL in the National Cancer Institute’s Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE study, a population-based cohort (n=484, age 15-39, diagnosed with cancer 6-14 months prior, in 2007-2009. Unmet service needs were psychosocial, physical, spiritual, and financial services where respondents endorsed that they needed, but did not receive, a listed service. Linear regression models tested associations between any or specific unmet service needs and HRQOL, adjusting for demographic, medical and health insurance variables.Results: Over one-third of respondents reported at least one unmet service need. The most common were financial (16%, mental health (15%, and support group (14% services. Adjusted models showed that having any unmet service need was associated with worse overall HRQOL, fatigue, physical, emotional, social, and school/work functioning, and mental health (p’s<0.0001. Specific unmet services were related to particular outcomes (e.g., needing pain management was associated with worse overall HRQOL, physical and social functioning (p’s<0.001. Needing mental health services had the strongest associations with worse HRQOL outcomes; needing physical/occupational therapy was most consistently associated with poorer functioning across domains.Discussion: Unmet service needs in AYAs recently diagnosed with cancer are associated with worse HRQOL. Research should examine developmentally appropriate, relevant practices to improve access to services demonstrated to adversely impact HRQOL, particularly physical therapy and mental

  14. Colon cancer

    Science.gov (United States)

    Colorectal cancer; Cancer - colon; Rectal cancer; Cancer - rectum; Adenocarcinoma - colon; Colon - adenocarcinoma ... In the United States, colorectal cancer is one of the leading causes of deaths due to cancer. Early diagnosis can often lead to a complete cure. Almost ...

  15. Preface to the third monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available Fashions come and go. Filmstars have their hey days and sink into oblivion. Technological gadgets become outdated sometimes even before they enter the market. Everyone wants the latest in TVs, computers, mobiles, cars, household appliances, industrial machinery, the works.We want to hear the latest news. Nobody prefers to read yesterday's newspaper today out of choice. We also want to read the latest edition of a book, and look up recent references and research work.We want the latest in treatments as well. The most recent is always considered an advancement over what was available earlier. Newer therapies, newer investigations, newer procedures.But, at the some time, we want to go to the senior consultant. And, given a choice, the older the better. Even elsewhere, we do not go to the junior most person to solve our problems if we can approach the senior man, and he is amenable. The recent graduate or postgraduate has the latest information, but it is the senior man who sits on the panel of examiners.We want the most recent in some cases, and the older and more experienced in others. Why should this happen? How should we handle our great need to update our knowledge on the latest, and yet not neglect the old and time-tested?This dilemma occurs in the research field as well, and psychiatry is no exception.What can be a healthy way of resolving this issue is the subject matter of this monograph.

  16. Preface to the fourth monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available The truth knocks on the door and you say, 'Go away, I am looking for the truth, and it goes away. Puzzling.- Robert M. Pirsig*There is an original and there is a copy. The copy can never achieve the status of an original. This is true not only of the arts, but of research as well, for there is original research and there is replicative research. But even replicative research has its own potential. It helps determine whether the original research findings are universally applicable, and/or whether they are faulty in methodology and design. Corrections are then possible. And this is how scientific research has progressed anyway.A lot of Indian research is replicative in nature, but it can as well be useful if it does not lose sight of this perspective. And how do we involve Indian Science into original research? Well, that's a different ball game altogether, not that its not already been played here. However, it needs a different mental set, and social ethos, which are discussed in the monograph that follows.What is scientific temper? How does it differ from other attitudes? How should it handle religion, faith, superstition and other such entities? The corner stone of scientific temper is the worth of evidence, howsoever damning to the most established of theories and paradigms. And the ability to withhold comment, or to take sides, till suitable evidence is available. Which means a true scientist should not act a know - all, nor need he have a viewpoint to air on everything under the sun.Is Science for Man, or Man for Science? This is a disturbing but fundamental question which all scientists, moral philosophers and other thinkers, must indeed attempt to answer. The two sides of this argument are presented in this essay to generate further dialogue.

  17. Preface to the seventh monograph

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2005-01-01

    Full Text Available Like all good neighbours, competing schools of psychiatry claw at each other. Like all good samaritans, some people try to play arbiters and douse the fires. The tradition of fights and retaliation is not new to psy­chiatry, neither is it unique to the branch. Competing schools of thought exist almost everywhere. And it is tempting to say that the more intellec­tually robust a field, the greater the controversies and fights in it.In fact if intellectuals were to come together and not voice differences, either they are not intellectuals, or they have no opinions. (Or they may be simply scared, or silenced for other reasons.Ofcourse we must note that while in other fields of thought there can be controversies, there is one essential difference. They may not be dealing with patients and their lives. And to that the corollary is that psychiatric controversies should not be carried out at the expense of patient welfare.Having said that, let us also note that when there are fights, arbiters become very active. As do advocates, of one or the other approach.In this monograph we have tried to act the arbiters. Maybe because it is appropriate. Maybe also because that's the only thing we can do (and may be do well: atleast that's what we would love to believe.Why not advocates ? Well, for one, there are so many already. For another, we run the risk of doing a poor job of it.Not that we have necessarily done a good job of being arbiters.

  18. Colonic lipoma

    Directory of Open Access Journals (Sweden)

    Hsu-Heng Yen

    2014-01-01

    Full Text Available Lipomas are benign soft tissue tumors derived from mature adipocytes. The colon is the most commonly involved organ in the entire gastrointestinal tract. Most gastrointestinal tract lipomas are asymptomatic and found incidentally during endoscopy, surgery or radiological examinations. In this video, we show the typical endoscopic findings of colonic lipomas.

  19. Launching a Research Agenda: The Early Monograph Series.

    Science.gov (United States)

    Hebert, Elsie S.

    1996-01-01

    Presents a description and review of seven monographs that were part of a series published by Louisiana State University Press between 1940 and 1963. Notes that the monographs dealt with newspaper circulation, Thomas Jefferson and the press, management of newspaper correspondents, journalism research, Oliver Kirby Bovard, and mass communication…

  20. Online group-based cognitive-behavioural therapy for adolescents and young adults after cancer treatment: A multicenter randomised controlled trial of Recapture Life-AYA

    Directory of Open Access Journals (Sweden)

    Sansom-Daly Ursula M

    2012-08-01

    -based programs in an online modality are highlighted, and the role of both peer and caregiver support in enhancing the effectiveness of this skills-based intervention is also discussed. The innovative videoconferencing delivery method Recapture Life uses has the potential to address the geographic and psychological isolation of adolescents and young adults as they move toward cancer survivorship. It is expected that teaching AYAs coping skills as they resume their normal lives after cancer may have long-term implications for their quality of life. Trial Registration ACTRN12610000717055

  1. Colon Cancer

    Centers for Disease Control (CDC) Podcasts

    2013-11-05

    In this podcast, Dr. Tom Frieden, CDC Director, discusses colon cancer and the importance of early detection.  Created: 11/5/2013 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/6/2014.

  2. Examining relationship between burnout level and socio-demographic characteristics of teachers: A case study for Ayaş, Güdül, Beypazarı, Nallıhan

    OpenAIRE

    Burhan Başoğlu; Mustafa Önder Şekeroğlu; Emrah Altun

    2016-01-01

    In this study, Maslach Burnout Inventory was used to determine the relationship between 533 teachers’ level of burnout; who work in Ayaş, Güdül, Beypazarı and Nallıhan provinces in the northern of Ankara in different positions and their socio-demographic variables. According to obtained data results; number of children, staff position and felt wealth level in desensitisation dimension and gender, education level and staff position in personal success dimension were determined as significant. ...

  3. Conceptual Foundations of Mens Sana Monographs

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    Full Text Available Mens Sana Monographs (MSM tend to look at events and issues from a somewhat different perspective. There are two main types of publications. Both serve important needs and have a committed readership. One type tends to be academic and technical to the extent of being incomprehensible to anyone except one intimately connected with the subject. These are the mainstream academic research publications of the respective disciplines. One the other hand are periodicals that cater to the interests of the moment, which are racy, sensational and as easily forgotten as eagerly read. (Not that they lay claims to any eternality. These are the newspapers, magazines, tabloids and other periodicals which fulfil our need to be aware of the multiplicity of the environment in which we exist. Both these approaches, though important, however leave a gap. The academic can be too austere for comfort, the tabloid too familiar for deeper reflection; the former too bland, the latter too spicy. An approach that provides food for thought and reflection without being too technical and elitist is therefore likely to bridge the divide between them. In other words, neither bland nor spicy: nutritious but without foregoing taste. MSM has been an attempt in that direction. This middle path is the first fundamental pillar of this publication.

  4. Examining relationship between burnout level and socio-demographic characteristics of teachers: A case study for Ayaş, Güdül, Beypazarı, Nallıhan

    Directory of Open Access Journals (Sweden)

    Burhan Başoğlu

    2016-04-01

    Full Text Available In this study, Maslach Burnout Inventory was used to determine the relationship between 533 teachers’ level of burnout; who work in Ayaş, Güdül, Beypazarı and Nallıhan provinces in the northern of Ankara in different positions and their socio-demographic variables. According to obtained data results; number of children, staff position and felt wealth level in desensitisation dimension and gender, education level and staff position in personal success dimension were determined as significant. It was concluded that marital status, duration of experience in job and staff position in management were not statistically significant on emotional exhaustion, desensitisation and personal success.

  5. A foundation monograph of Convolvulus L. (Convolvulaceae

    Directory of Open Access Journals (Sweden)

    John R.I. Wood

    2015-06-01

    . stocksii (Boiss. J.R.I.Wood & R.W.Scotland, comb. et stat. nov., Convolvulus calvertii subsp. ruprechtii (Boiss. J.R.I.Wood & R.W.Scotland, stat. nov., Convolvulus cephalopodus subsp. bushiricus (Bornm. J.R.I.Wood & R.W.Scotland, stat. nov. The status of various infraspecific taxa is clarified and numerous taxa are lectotypified. This account represents a new initiative in terms of taxonomic monography, being an attempt to bring together the global approach of the traditional monograph with the more pragmatic and identification-focussed approach of most current floras while at the same time being informed by insights from molecular systematics.

  6. Systematic organization of medicinal plant information: a monograph template proposal

    Directory of Open Access Journals (Sweden)

    Ana C.B. Carvalho

    2014-01-01

    Full Text Available The use of medicinal plants in Brazil is widespread and is supported by public policies; it has the objective of providing the population with safe and effective herbal medicines of adequate quality. An action in these policies is to develop medicinal plant monographs to gather published information and decide which medicinal plants should be financed by the Brazilian government and distributed by the public health system. Currently, the monographs published worldwide do not present unified information regarding medicinal plants, and generally, they do not cover enough requirements for herbal medicine registration. The aim of this study is to develop a monograph model with standardized information not only about botany, agronomy, quality control, safety, and efficacy but also about relating regulatory aspects that support herbal medicine regulation. The development of standardized monographs favors the fast authorization and distribution of herbal medicines in the public system. The model also points out the lacking studies that should be carried out to supplement the necessary regulatory information of medicinal plants.

  7. Higher Education in the USSR. Monographs on Higher Education.

    Science.gov (United States)

    Savelyev, A. Y.; And Others

    This monograph describes the system of higher education in the United Soviet Socialist Republics (USSR). The preface points out that despite perestroika, two features of Soviet education persist, a high degree of unity and centralization and a close link between higher education and employers. Chapter 1, "Historical Overview," begins with 4th…

  8. Supplement to a monograph of the Indo-Australian Clausiliidae

    NARCIS (Netherlands)

    Loosjes, F.E.

    1963-01-01

    Since the publication of my monograph of the Indo-Australian Clausiliidae (Loosjes, 1953) I obtained some additional information, consisting mainly of new distribution records and data on shell-structures. The present paper deals with these additional data, while furthermore two new species are desc

  9. Accountability in Education: A Primer for School Leaders. HSLA Monograph.

    Science.gov (United States)

    Heim, Michael

    School leaders are increasingly coming under the gun of accountability, and this monograph is designed to help leaders think about, understand, and respond thoughtfully and effectively to the increasing demands for accountability in education. It provides a comprehensive and rather sophisticated set of concepts and insights into accountability…

  10. Natural risks assessment and management (project of monograph)

    International Nuclear Information System (INIS)

    Full text of publication follows: large-scale theoretic and practical works on the issue of natural risk assessment and management started in Russia in the end of the 80's. By now there has been made a considerable progress, which allowed for the preparation of a collective monograph on the subject mentioned in the title of this abstract. It is supposed to be published in 1999 in order to become a Russian contribution to the International Decade of Natural Disasters Reduction. The monograph included 6 chapters with the following titles: 1. Methodological foundations of natural risk analysis and assessment. 2. Investigating and forecasting natural hazards for the purpose of risk assessment. 3. Assessment of economic, social and ecological damage from natural hazards. 4, Theory of natural risk assessment. 5. Examples of natural risk assessment and mapping. 6. Natural risk management. In the report there is described the content of the monograph and unsolved questions are discussed. Executive editor offers all international experts to cooperate in the compilation of this monograph, which is to be completed by the end of 1998, especially of chapter 5 and 6. (author)

  11. Hungarians and Jews. An Important Monograph with Deficit

    OpenAIRE

    Magdolna Balogh

    2015-01-01

    Hungarians and Jews. An Important Monograph with DeficitThe texts is a critical review of the book: Géza Komoróczy: The History of the Jews in Hungary I-II., Kalligram, Pozsony, 2012. 1230 and 1213 pp.

  12. Hungarians and Jews. An Important Monograph with Deficit

    Directory of Open Access Journals (Sweden)

    Magdolna Balogh

    2015-06-01

    Full Text Available Hungarians and Jews. An Important Monograph with DeficitThe texts is a critical review of the book: Géza Komoróczy: The History of the Jews in Hungary I-II., Kalligram, Pozsony, 2012. 1230 and 1213 pp.

  13. Trends in Source of Catalog Records for European Monographs 1996-2000: A Preliminary Study of Italian Monographs.

    Science.gov (United States)

    Kellsey, Charlene

    2001-01-01

    Discusses catalog records for non-English books created by European booksellers and loaded into OCLC; describes a study of Italian language monographs to compare vendor records with Library of Congress and OCLC member libraries' records; and considers changes in cataloging workflow needed to edit records to include Library of Congress call numbers…

  14. The vital few meet the trivial many: unexpected use patterns in a monographs collection.

    Science.gov (United States)

    Eldredge, J D

    1998-01-01

    PURPOSE: To test three related hypotheses about monographs circulation at academic health sciences libraries: (1) Juran's "Vital Few" Principle, sometimes incorrectly referred to as the "Pareto Principle"; (2) most (> 30%) new monographs will not circulate within four years; and, (3) Trueswell's 20/80 rule concerning intensity of monographs circulation. METHODS: Retrospective circulation study conducted at a major academic health sciences library in November 1997 on monographs acquired during 1993, utilizing an online review file. RESULTS: Unexpectedly, most monographs (84%) had circulated at least once in the four years following acquisition. Combining circulation and in-house data revealed that 90.7% of the monographs acquired in 1993 had been used at least once. Small percentages of these monographs produced disproportionately high circulation levels. CONCLUSION: Monographs circulation rates confirm Juran's Vital Few principle. Most monographs circulated at least once in contrast to results reported by the Pittsburgh Study or other studies reported by Hardesty and Fenske. The results do not comply with Trueswell's 20/80 ratio rule. Further research needs to investigate the effects of low students to books ratios and problem-based learning (PBL) curricula upon monographs utilization. PMID:9803291

  15. The monographic sociology from the perspective of American critical ethnography

    OpenAIRE

    Șerban Văetiși

    2013-01-01

    The paper attempts to reconsider some theoretical and methodological principles practiced by the Bucharest School of Sociology by invoking some concepts put forward by the so called Critical Ethnography. It considers three major ideas of the Monographic Sociology, that can be also found as theoretical assumptions of the postmodern critical ethnographic theory, in an interesting parallel that can be, thus, reconstructed and further suggested as useful paradigm within current approaches in soci...

  16. Scholarly monographs on rock music: a bibliographic essay

    OpenAIRE

    Berger, Monica

    2008-01-01

    Purpose: This article is an overview of scholarly monographs on rock music from 1980 to the present. It provides an overview to the literature for practical purposes of collections development as well as giving the reader insight into key issues and trends related to a interdisciplinary topic that attracts scholars from many disciplines in the humanities and social sciences. Design/methodology/approach: This bibliographic essay, focusing on works related to American culture and of a gen...

  17. Monograph of Keçiören Municipality

    Directory of Open Access Journals (Sweden)

    Savaş Zafer Şahin

    2015-12-01

    Full Text Available In Turkey, urban administration can be defined from a judicial perspective as the bundle of powers vested in municipalities. It is known that throughout republican history, municipalities, using these powers, have differentiated themselves via their own internal dynamics in parallel to the evolution of public policy and changes in legislation. Yet, it is obvious that there are important gaps in understanding this differentiation taking into consideration the structural conditions of individual municipalities. In particular, in order to thoroughly understand municipalities, it is important to consider periodical pictures of how each municipality has been affected by waves of decentralization and centralization experienced over the last thirty years. In this respect, this monograph, using the same monographic approach developed for the Çankaya Municipality, provides a picture of the existing situation of Ankara’s Keçiören Municipality and presents related problems and potential. This monograph, based on qualitative and quantitative research, presents a holistic evaluation of Keçiören Municipality in terms of its external environment, provision of services, decision-making processes, use of technology and communications.

  18. Colon cancer - Series (image)

    Science.gov (United States)

    Colon cancer is the third most common cancer in the United States. Risk factors include a diet low ... The treatment of colon cancer depends on the stage of the disease. Stage I cancer is limited to the inner lining of the colon; ...

  19. Running a Contest to Encourage Timely Monograph Ordering

    OpenAIRE

    Cramer, Carol J

    2013-01-01

    An age-old problem: Whatever deadline you set for placing monograph orders, you receive a big burst of orders at the last minute. Acquisitions staff beg for book orders one month and get flooded with orders the next. Librarians at Wake Forest University tried to mitigate this problem by running a contest: spend 65% of your target by an early deadline, and your fund wins a share of a cash prize. The presenter will discuss how the contest idea proved an effective incentive for selectors and how...

  20. Colon capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Ignacio Fernandez-Urien; Cristina Carretero; Ana Borda; Miguel Mu(n)oz-Navas

    2008-01-01

    Wireless capsule endoscopy has become the first imaging tool for small bowel examination.Recently,new capsule endoscopy applications have been developed,such as esophageal capsule endoscopy and colon capsule endoscopy.Clinical trials results have shown that colon capsule endoscopy is feasible,accurate and safe in patients suffering from colonic diseases.It could be a good alternative in patients refusing conventional colonoscopy or when it is contraindicated.Upcoming studies are needed to demonstrate its utilty for colon cancer screening and other indications such us ulcerative colitis.Comparative studies including both conventional and virtual colonoscopy are also required.

  1. Contributions of Wilbur Schramm to Mass Communication Research. Journalism Monograph No. 36.

    Science.gov (United States)

    Chaffee, Steven H., Ed.; And Others

    This monograph describes the philosophical, theoretical, and research contributions of Wilbur Schramm in the field of mass communication research. In the papers that comprise this monograph, three of Schramm's principal areas of investigation are reviewed. Jack Lyle looks at both the integration of mass communication into the field of education…

  2. The Voice of America: Policies and Problems. Journalism Monographs No. 43.

    Science.gov (United States)

    Browne, Donald R.

    1976-01-01

    This issue of "Journalism Monographs" is devoted to a discussion of the Policies and problems of the international broadcasting operation "The Voice of America" (VOA). The monograph begins with an examination of the origins of America's entry into international broadcasting and the creation of the Office of War Information in 1942. The VOA's…

  3. 75 FR 30838 - Drometrizole Trisiloxane Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the...

    Science.gov (United States)

    2010-06-02

    ... Eligibility for Potential Inclusion in Sunscreen Monograph; Over-the-Counter Sunscreen Drug Products for Human... it is eligible to be considered for inclusion in our OTC drug monograph system. We will evaluate the... requirements of the National Environmental Policy Act of 1969 (NEPA). DATES: Submit data, information,...

  4. CT Findings of Colonic Complications Associated with Colon Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Won; Shin, Hyeong Cheol; Kim, Il Young; Kim, Young Tong; Kim, Chang Jin [Cheonan Hospital, Soonchunhyang University, Cheonan (Korea, Republic of)

    2010-04-15

    A broad spectrum of colonic complications can occur in patients with colon cancer. Clinically, some of these complications can obscure the presence of underlying malignancies in the colon and these complications may require emergency surgical management. The complications of the colon that can be associated with colon cancer include obstruction, perforation, abscess formation, acute appendicitis, ischemic colitis and intussusception. Although the majority of these complications only rarely occur, familiarity with the various manifestations of colon cancer complications will facilitate making an accurate diagnosis and administering prompt management in these situations. The purpose of this pictorial essay is to review the CT appearance of the colonic complications associated with colon cancer.

  5. Colon and rectal cancer

    International Nuclear Information System (INIS)

    This study is about the diagnosis, therapy and monitoring of colon cancer. The techniques used are the endoscopy with biopsy in the pre and post operative colon surgery, abdominal ultrasound, chest X-ray studies of hemogram as well as liver and renal function

  6. Sonography in Colonic Diverticulitis

    International Nuclear Information System (INIS)

    To evaluate the sonographic findings and the diagnostic value of colonic diverticulitis. We evaluated the sonograms of 26 patients with colonic diverticulitis retrospectively. The final diagnosis was based on the pathologic interpretation of a surgical specimen (5 cases), clinical course (21 cases), on barium enema (12 cases) and colonoscopy (1 case). Twenty-five patients had acute diverticulitis in the cecum and 1 patient in the descending colon. On sonography, an oval or short tubular focus which protruded from the colonic wall was seen in 23 patients (88%) and the longest diameter were from 0.5 cm to 3 cm (mean 1.4cm). The lesions were echogenic in 8 cases and hypoechoic in 17 cases. Segmental thickening of the colonic wall was seen in 13 patients (50%), of these, protruding focus was seen in 92%. Pericolic abscess located inposterolateral and medial portion to the colon was seen in 11 patients (42%). Infiltration in pericolic fat(50%), enlargement of pericolic lymph nodes (27%) and small pericolic fluid (8%) were also seen. Our results show that ultrasonography is useful technique in the diagnosis of colonic diverticulitis and in the differentiation from acute appendicitis

  7. Acacia mangium: Growing and utilization. MPTS monograph series No. 3

    Energy Technology Data Exchange (ETDEWEB)

    Awang, K.; Taylor, D.

    1993-01-01

    With deforestation in the Asia-Pacific region progressing at the rate of 4.4 million ha per year, many countries have adopted plantation forestry using fast-growing species as a way to sustain the commercial supply of tree products and reduce pressure on natural forests. Acacia mangium (A. mangium) is playing a large role in this development, especially in Indonesia and Malaysia, due to its versatility and its ability to recapture grasslands dominated by the noxious weed, Imperata cylindrica. This monograph consolidates information on A. mangium from published literature, unpublished reports and studies, and observations from those familiar with the species. Priorities for future research are included in each chapter and in the final summary.

  8. New Analytical Monographs on TCM Herbal Drugs for Quality Proof.

    Science.gov (United States)

    Wagner, Hildebert; Bauer, Rudolf; Melchart, Dieter

    2016-01-01

    Regardless of specific national drug regulations there is an international consensus that all TCM drugs must meet stipulated high quality standards focusing on authentication, identification and chemical composition. In addition, safety of all TCM drugs prescribed by physicians has to be guaranteed. During the 25 years history of the TCM hospital Bad Kötzting, 171 TCM drugs underwent an analytical quality proof including thin layer as well as high pressure liquid chromatography. As from now mass spectroscopy will also be available as analytical tool. The findings are compiled and already published in three volumes of analytical monographs. One more volume will be published shortly, and a fifth volume is in preparation. The main issues of the analytical procedure in TCM drugs like authenticity, botanical nomenclature, variability of plant species and parts as well as processing are pointed out and possible ways to overcome them are sketched. PMID:27271998

  9. Evaluation of the TALON Cooperative Acquisitions Program for monographs.

    Science.gov (United States)

    Bowden, V M; Comeaux, E A; Eakin, D

    1984-07-01

    The TALON Cooperative Acquisitions Program for monographs (TALON/CAP) was implemented in 1979 by eleven resource libraries in the South Central Regional Medical Library Program. Each participating library acquired books from selected publishers within a profile covering subject and format. The program was evaluated by comparing interlibrary loan requests, surveying participants, and analyzing cataloging records. The results were that ten of the eleven libraries significantly increased their coverage of assigned publishers, and that academic medical libraries are not all buying the same books, even from major medical publishers. The fifty-six publishers in the program accounted for 60% to 83% of the titles with 1977-80 imprints held by participating libraries. The computer-generated collection analysis reports provide a baseline for future collection management studies. PMID:6743874

  10. Stages of Colon Cancer

    Science.gov (United States)

    ... for information about colorectal cancer in children. Health history can affect the risk of developing colon cancer. ... through. This procedure is called a colostomy. A bag is placed around the stoma to collect the ...

  11. Laparoscopic Colon Resection

    Science.gov (United States)

    ... inches to complete the procedure. What are the Advantages of Laparoscopic Colon Resection? Results may vary depending ... type of procedure and patient’s overall condition. Common advantages are: Less postoperative pain May shorten hospital stay ...

  12. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... medical communities and their patients. Preliminary Topic and Availability of Meeting Materials The... decisions about human hazard, setting ] research and testing priorities, and providing information to... laboratory animals. OHAT has prepared a comprehensive draft NTP Monograph that summarizes the effects...

  13. Definition of the standard format to prepare descriptive monographs of ITACA stations

    OpenAIRE

    Di Capua, G.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione AC, Roma, Italia; Lanzo, G.; Dipartimento di Ingegneria Strutturale e Geotecnica - Sapienza Università di Roma; Peppoloni, S.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione AC, Roma, Italia; Scasserra, G.; Dipartimento di Ingegneria Strutturale e Geotecnica - Sapienza Università di Roma

    2009-01-01

    In the previous S6 Project (2004-2007 DPC-INGV Framework Program) a monograph was carried out, that was drawn up for many stations, that were part of the former ENEL accelerometric network. In these monographs all the ENEL documentation about geological information as well as geognostic and geophysical data was included. Knowledge of geological and geomorphological context, and the mechanical and dynamic characteristics of the stations subsoil is fundamental for studies on the att...

  14. Treatment Option Overview (Colon Cancer)

    Science.gov (United States)

    ... Colorectal Cancer Colorectal Cancer Screening Research Colon Cancer Treatment (PDQ®)–Patient Version General Information About Colon Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) and treatment ...

  15. Understanding your colon cancer risk

    Science.gov (United States)

    Colon cancer risk factors are things that increase the chance that you could get cancer. Some risk factors ... risk factors never get cancer. Other people get colon cancer but do not have any known risk factors. ...

  16. Colonic interposition: radiographic evaluation.

    Science.gov (United States)

    Agha, F P; Orringer, M B

    1984-04-01

    This report reviews the clinical and radiographic features of 40 patients who underwent visceral esophageal substitution with colon for benign or malignant lesions of the esophagus. The incidence and radiographic identification of complications are discussed. All patients were routinely examined with barium esophagrams on postoperative day 10. If an anastomotic leak was suspected clinically before this time, studies were performed using water-soluble iodinated contrast material. Follow-up barium esophagrams were obtained 1-96 months after operation (average, 60 months) in 24 patients. Eight patients (21%) demonstrated asymptomatic "jejunization" of the colonic mucosa with no attributable clinical manifestations; this finding resolved in 1-3 months, without sequelae, and has not been reported before. The spectrum of ischemic changes in the colonic segment included mucosal edema, spasm, ulceration, loss of haustration, and frank necrosis. Radiographically detectable early postoperative complications included anastomotic leak in six (three pharyngocolic, three cervical esophagocolic) and aspiration of barium into the tracheobronchial tree due to incoordinated swallowing in eight. Late postoperative complications included anastomotic narrowing (12) malfunctioning of the colon due to impaired emptying (five), recurrent aspiration pneumonia (three), small bowel obstruction (three), transhiatal herniation of small bowel through the diaphragmatic hiatus (one), and reflux into the retained bypassed esophagus (one). PMID:6608225

  17. Colonization, mouse-style

    Directory of Open Access Journals (Sweden)

    Searle Jeremy B

    2010-10-01

    Full Text Available Abstract Several recent papers, including one in BMC Evolutionary Biology, examine the colonization history of house mice. As well as background for the analysis of mouse adaptation, such studies offer a perspective on the history of movements of the humans that accidentally transported the mice. See research article: http://www.biomedcentral.com/1471-2148/10/325

  18. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans

    Science.gov (United States)

    Blair, Aaron; Vineis, Paolo; Ahrens, Wolfgang; Andersen, Aage; Anto, Josep M.; Armstrong, Bruce K.; Baccarelli, Andrea A.; Beland, Frederick A.; Berrington, Amy; Bertazzi, Pier Alberto; Birnbaum, Linda S.; Brownson, Ross C.; Bucher, John R.; Cantor, Kenneth P.; Cardis, Elisabeth; Cherrie, John W.; Christiani, David C.; Cocco, Pierluigi; Coggon, David; Comba, Pietro; Demers, Paul A.; Dement, John M.; Douwes, Jeroen; Eisen, Ellen A.; Engel, Lawrence S.; Fenske, Richard A.; Fleming, Lora E.; Fletcher, Tony; Fontham, Elizabeth; Forastiere, Francesco; Frentzel-Beyme, Rainer; Fritschi, Lin; Gerin, Michel; Goldberg, Marcel; Grandjean, Philippe; Grimsrud, Tom K.; Gustavsson, Per; Haines, Andy; Hartge, Patricia; Hansen, Johnni; Hauptmann, Michael; Heederik, Dick; Hemminki, Kari; Hemon, Denis; Hertz-Picciotto, Irva; Hoppin, Jane A.; Huff, James; Jarvholm, Bengt; Kang, Daehee; Karagas, Margaret R.; Kjaerheim, Kristina; Kjuus, Helge; Kogevinas, Manolis; Kriebel, David; Kristensen, Petter; Kromhout, Hans; Laden, Francine; Lebailly, Pierre; LeMasters, Grace; Lubin, Jay H.; Lynch, Charles F.; Lynge, Elsebeth; ‘t Mannetje, Andrea; McMichael, Anthony J.; McLaughlin, John R.; Marrett, Loraine; Martuzzi, Marco; Merchant, James A.; Merler, Enzo; Merletti, Franco; Miller, Anthony; Mirer, Franklin E.; Monson, Richard; Nordby, Karl-Cristian; Olshan, Andrew F.; Parent, Marie-Elise; Perera, Frederica P.; Perry, Melissa J.; Pesatori, Angela Cecilia; Pirastu, Roberta; Porta, Miquel; Pukkala, Eero; Rice, Carol; Richardson, David B.; Ritter, Leonard; Ritz, Beate; Ronckers, Cecile M.; Rushton, Lesley; Rusiecki, Jennifer A.; Rusyn, Ivan; Samet, Jonathan M.; Sandler, Dale P.; de Sanjose, Silvia; Schernhammer, Eva; Costantini, Adele Seniori; Seixas, Noah; Shy, Carl; Siemiatycki, Jack; Silverman, Debra T.; Simonato, Lorenzo; Smith, Allan H.; Smith, Martyn T.; Spinelli, John J.; Spitz, Margaret R.; Stallones, Lorann; Stayner, Leslie T.; Steenland, Kyle; Stenzel, Mark; Stewart, Bernard W.; Stewart, Patricia A.; Symanski, Elaine; Terracini, Benedetto; Tolbert, Paige E.; Vainio, Harri; Vena, John; Vermeulen, Roel; Victora, Cesar G.; Ward, Elizabeth M.; Weinberg, Clarice R.; Weisenburger, Dennis; Wesseling, Catharina; Weiderpass, Elisabete; Zahm, Shelia Hoar

    2015-01-01

    Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans. Objectives: The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed. Discussion: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed. Conclusions: The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public’s health. Citation: Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP

  19. External coating of colonic anastomoses

    DEFF Research Database (Denmark)

    Pommergaard, Hans-Christian; Achiam, Michael Patrick; Rosenberg, Jacob

    2012-01-01

    Colon anastomotic leakage remains both a frequent and serious complication in gastrointestinal surgery. External coating of colonic anastomoses has been proposed as a means to lower the rate of this complication. The aim of this review was to evaluate existing studies on external coating of colonic...

  20. Preface to the first monograph: The Fourth Psychiatric Revolution

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2004-05-01

    the one hand, and cautious forays in the neurosciences, adoption and genetic studies on the other ( from where, hopefully, significant leads in understanding the aetiology of major psychiatric disorders must arise. Diagnostic refinement is a necessary step in this direction, as is use of sophisticated technology to aid the process.And yet, we know that psychiatry, its practitioners, and its patients, do not function in a vacuum. They interact with, and are influenced by, a wide range of complex, interlinked, social and interpersonal forces.These forces are often generated by people not directly connected with the medical speciality of psychiatry. They are the policy-planners, governments, political leaders, activists, social thinkers, NGOs, mass media, enlightened public opinion etc. They have marked influence on social thought and action, policy, funding and research. They influence people and societies often in more significant ways than the medical speciality of psychiatry considers healthy for society.We may continue to function in a vacuum and wait for wisdom to dawn. Or, we may establish a dialogue with them and work for wisdom for happen.The second option seems the more productive one.No doubt, there are some psychiatrists comfortable with the biological label. There are others comfortable with the social one. Both these are needed, for they help to further robust enquiry in their respective fields. But what we also probably need is an integration, a synthesis of the mass of evidence that these two fields have produced. The inevitable conclusions drawn at our present state of knowledge based on such integration will give rise to pointers for further research as well as guidelines for policy-planners. Moreover, it will result in an awakened public opinion empowered with knowledge and evidence, its actions enlightened, and unlikely to be swayed or manipulated by unscrupulous forces.The Mens Sana Monographs are meant to further attempts at such a Fourth

  1. Sonographic Features of Colonic Diverticulitis

    International Nuclear Information System (INIS)

    To evaluate sonographic features, location of diverticulum, and usefulness of sonography as a primary diagnostic tool. Sonographic findings of 28 patients with acute diverticulitis were reviewed. The diagnosis was made by surgery (11 patients), barium enema (20 patients), colonoscopy (3 patients), or CT (2 patients). There were 13 men and 15 women with ages ranging from 23 to 71 years old (mean, 33 years old). Sonographic abnormalities were seen in the cecum in 12 patients, both the cecum and ascending colon in seven, the ascending colon in six, the descending colon in two, and the transverse colon in one. On sonography, segmental thickening of the colonic wall was the most common finding, seen in 16 patients. The second most common finidngs were pericolic omental thickening and pericolic localized fluid collection (15 patients). Pericolic inflammatory mass of varying echogenicity (10 patients), out pouching hyper echoic foci beyond the lumen of the colon into or beyond the thickened wall (5 patients), contracture of the colon (5 patients), slightly thickened terminal ileum (1 patient), and local enlargement of ileocecal lymph node (1 patient) were also seen. Most diverticulitis occurred in the right colon. The useful sonographic findings in acute diverticulitis were echogenic foci of the diverticulum in the thickened colonic wall, focally and eccentrically thickened colonic wall, and localized omental thickening or fluid collection. In cases of pericecal fluid collection, appendicitis or colonic diverticulitis can be considered as a differential diagnosis

  2. On Justification of Colonization

    OpenAIRE

    Skov, Stig; Schrøder, Ulrikke; Mortensen, Marianne; Memic, Inda; Asmussen, Pernille

    2007-01-01

    Abstract The project concerns the justification of the Spanish colonization in America during the 16th and 17th century, examined through the Spanish philosopher Francisco de Vitoria’s (1485 – 1546) Political Writings and the British philosopher John Locke’s (1632- 1704) Two Treatises of Government, in a historical as well as a philosophical context. The main problem has been the dispossession of the Indians and how the philosophers defended the occupation of the lands of America. Vitoria’...

  3. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... announced on August 17, 2011 (76 FR 51034). Information about rescheduling the release of the draft... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and...

  4. Review of the Monograph “Colour. City. Culture” by O.E. Zheleznyak

    OpenAIRE

    Irina Dobritsyna

    2015-01-01

    The author of the review, professor I. A. Dobritsyna evaluates the Monograph “Colour. City. Culture” by O.E. Zheleznyak as a distinctive work. This thorough and methodically organized monograph presents a profound idea of the colour phenomenon as a part of the culture and the city life and observes a new untraditional treatment of colour and its role in the space of culture and the city. This work can be recommended as a scientific publication for a wide range of specialists and as a manual f...

  5. Review of the Monograph “Colour. City. Culture” by O.E. Zheleznyak

    Directory of Open Access Journals (Sweden)

    Irina Dobritsyna

    2015-08-01

    Full Text Available The author of the review, professor I. A. Dobritsyna evaluates the Monograph “Colour. City. Culture” by O.E. Zheleznyak as a distinctive work. This thorough and methodically organized monograph presents a profound idea of the colour phenomenon as a part of the culture and the city life and observes a new untraditional treatment of colour and its role in the space of culture and the city. This work can be recommended as a scientific publication for a wide range of specialists and as a manual for higher educational institutions, which train specialists in architecture and design, monumental-decorative and decorative-applied arts.

  6. Harmonization of monographic standards is needed to ensure the quality of Chinese medicinal materials

    Directory of Open Access Journals (Sweden)

    Zhao Sandy

    2009-09-01

    Full Text Available Abstract This article provides an overview on the regulations of Chinese medicinal materials (CMMs in various countries and regions. Harmonization of CMM monographs would provide standards for the quality control of CMM products and play an important role in the modernization and globalization of Chinese medicine. A harmonized regulatory system would improve the quality of CMMs thereby ensuring the safety of the products and assisting Chinese medicine practitioners in their practice. The fast growing demand worldwide for traditional medicines calls for harmonized monographic standards to safeguard the safety and quality of CMM products.

  7. Bibliometric analysis of martial arts monographs published in Spain (1906-2006)

    OpenAIRE

    Mikel Pérez Gutiérrez; Carlos Gutiérrez García

    2012-01-01

    This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008), the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions) with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (kara...

  8. Analysis of Streptococcus bovis infections at a monographic oncological centre

    Directory of Open Access Journals (Sweden)

    Lozano TG

    2014-02-01

    Full Text Available The Streptococcus bovis is a Gram-positive, facultative anaerobic, catalase and oxidase negative coccus belonging to the genus Streptococcus. It is part of Streptoccus bovis/ equinus complex and it express the Lancefield antigen D on the surface.This complex has been characterized by molecular biology techniques and specifically by 16S rRNA and sodA gene. Phylogenetic trees based on these techniques are complex and therefore the routine work in laboratories, biochemical techniques are used to identify subspecies if it is necessary.The complex is divided into two subtypes based on biochemical properties: positive mannitol fermentation (biotype I including S. gallolyticus (S. gallolyticus subsp. gallolyticus and S. gallolyticus subsp. macedonicus, mannitol negative and ß-glucuronidase negative (biotype II/ 1, which includes more species (S. infantarius subsp. coli and S. lutetiensis and mannitol negative and ß-glucuronidase positive (biotype II/ 2, with a single species called S. gallolyticus subsp. pasteurianus.Owing to the relationship between colon cancer tumour and Streptococcus bovis, we intend to analyse all isolates in our hospital between the periods of 2010 until March 2013 and analyse tumor epidemiology at our center, in patients infected with this pathogen.Despite the different types of samples and out of the possibility of identification of subspecies, were isolated 14 S. bovis of 14 different patients. The isolates patients were (at the beginning: 4 blood (blood culture, 5 urine, 4 multiple exudates and 1 bronchoalveolar lavage. The proportion of men and women was 8/6. The mean age was 67 years (56±91. Malignant tumor distribution was: 6 prostate cancer, 1 breast cancer, 1 biliary tract, 1 skin, 1, stomach, 1 uterus, 1 vulvar, 1 pyriform sinus and other reproductive organs without specify.The study of antimicrobial in vitro susceptibility was performed by microdilution (MicroScan® WalkAway, Siemens, Sacramento, CA, USA and the

  9. Diffuse lymphoid follicles of the colon associated with colonic carcinoma.

    Science.gov (United States)

    Bronen, R A; Glick, S N; Teplick, S K

    1984-01-01

    In four patients aged 59-75 years, colonic carcinoma was associated with diffuse lymphoid follicles in the colon. In one case, the prominence and distribution of the lymphoid follicles corresponded to the progression and regression of the tumor bulk. It is extremely unusual to demonstrate lymphoid follicles, particularly diffuse, on barium enema in patients in this age range. The colonic carcinomas and lymphoid follicles are directly related, possibly representing an immune response. PMID:6606941

  10. Fungal infection of the colon

    OpenAIRE

    Praneenararat S

    2014-01-01

    Surat PraneenararatDivision of Gastroenterology, Department of Medicine, Prince of Songkla University, Songkhla, ThailandAbstract: Fungi are pathogens that commonly infect immunocompromised patients and can affect any organs of the body, including the colon. However, the literature provides limited details on colonic infections caused by fungi. This article is an intensive review of information available on the fungi that can cause colon infections. It uses a comparative style so that its con...

  11. Short colon in a cat

    International Nuclear Information System (INIS)

    An 11-year-old male Japanese domestic cat was referred to the veterinary hospital with a chronic diarrhea and signs of pain and vocalization when defecating. The cat has discharged unformed feces throughout his life. Morphological diagnosis of short colon was made radiographically after barium enema. The ileocolic junction and cecum was located to the left of the midline at the proximal end of the descending colon. Additional endoscopic examination demonstrated the difference in visual structures of the mucosal surface and in histological structures on mucosal biopsy specimens, between the colon and ileum. This is the first report of short colon in a cat in Japan

  12. Diverticulosis in total colonic aganglionosis

    International Nuclear Information System (INIS)

    Two infants with total colonic aganglionosis (TCA) extending into the distal part of the ileum are described. Considerable diagnostic delay occurred with the correct diagnosis established first at 3 and 8 months, respectively. Radiologic findings compatible with TCA such as prolonged barium retention, reflux into ileum following barium enema, and foreshortening of colon were not clearly evident initially. Both patients demonstrated multiple acquired colon diverticula which increased both in number and size during the period of observation. These diverticula are probably a late manifestation of the spastic state of the anganglionic colon. Thus demonstration of diverticula supplies a strong evidence of TCA in infants with intestinal obstruction. (orig.)

  13. Identifying Your School's Crime Problems: Simple Steps That Precede Costly Action. An IRC Monograph for Practitioners.

    Science.gov (United States)

    Rubel, Robert J., Ed.

    This monograph is intended to provide guidance to schools and school districts in two areas: in the identification and analysis of crime problems in schools and in the evaluation of security programs. Part 1 provides simple steps necessary to avoid problems in data collection that might cause confusion and misinterpretation of student violence…

  14. News Piracy: Unfair Competition and the Misappropriation Doctrine. Journalism Monographs No. 56.

    Science.gov (United States)

    Sullivan, Paul W.

    Unfair competition is a complex problem affecting all areas of American business, including the communications media. Piracy of material, an alarmingly widespread example of unfair competition, involves legal as well as ethical questions. This monograph uses the historical approach to trace the development of common-law precedent and trends and…

  15. Interactive Robotic Aids--One Option for Independent Living: An International Perspective. Monograph Number 37.

    Science.gov (United States)

    Foulds, Richard, Ed.

    The monograph is a collection of papers on the role of robotics in rehabilitation. The first four papers represent contributions from other countries: "Spartacus and Manus: Telethesis Developments in France and the Netherlands" (H. Kwee); "A Potential Application in Early Education and a Possible Role for a Vision System in a Workstation Based…

  16. Guide to open access monograph publishing for arts, humanities and social science researchers

    OpenAIRE

    Collins, Ellen; Milloy, Caren; Stone, Graham

    2015-01-01

    This guide has been produced to assist arts, humanities and social sciences (AHSS) researchers in understanding the state of play with regards to open access in the UK and what it means to them as current and future authors of scholarly monographs.

  17. Rural Substance Abuse: State of Knowledge and Issues. NIDA Research Monograph 168.

    Science.gov (United States)

    Robertson, Elizabeth B., Ed.; Sloboda, Zili, Ed.; Boyd, Gayle M., Ed.; Beatty, Lula, Ed.; Kozel, Nicholas J., Ed.

    This research monograph is based on papers from a technical review meeting of the same name, held April 26-27, 1994. It provides information about the special nature or context of rural communities that might impact patterns of drug and alcohol consumption and delivery of prevention and treatment services; health, social, and economic consequences…

  18. On the rise of Bayesian econometrics after Cowles Foundation monographs 10, 14

    NARCIS (Netherlands)

    N. Baştürk; C. Çakmaklı; S.P. Ceyhan; H.K. van Dijk

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  19. On the Rise of Bayesian Econometrics after Cowles Foundation Monographs 10, 14

    NARCIS (Netherlands)

    N. Basturk (Nalan); C. Cakmakli (Cem); S.P. Ceyhan (Pinar); H.K. van Dijk (Herman)

    2014-01-01

    markdownabstract__Abstract__ This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians

  20. On the rise of Bayesian econometrics after Cowles Foundation Monographs 10, 14

    NARCIS (Netherlands)

    Baştürk, N.; Çakmak, C.; Pinar Ceyhan, S.; van Dijk, H.K.

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation pat

  1. Administration and Supervision for Safety in Sports. Sports Safety Series: Monograph No. 1.

    Science.gov (United States)

    Borozne, Joseph, Ed.; And Others

    Examined in this monograph are issues concerned with accident problems in sports. Materials are organized under eight headings, each developed by an expert in the area: (1) the injury problem in sports; (2) philosophy of sports accident prevention and injury control; (3) an introduction to administration and supervision; (4) administration and…

  2. The Vocational Choice Process of Non-Professional Workers: Research Plan: Revised and Operationalized. Monograph 2.

    Science.gov (United States)

    Salomone, Paul R.

    This monograph provides a revised list of research hypotheses and questions, a detailed review of psychological and operational definitions of over fifteen vocational contructs (including such ambiguous concepts as vocational stability and vocational satisfaction), and an overview of projected research procedures. In addition, a comprehensive set…

  3. Nutritional Problems and Policy in Tanzania. Cornell International Nutrition Monograph Series, Number 7 (1980).

    Science.gov (United States)

    Mgaza, Olyvia

    This monograph discusses policies designed to deal with food and nutrition problems in Tanzania. Available information on food supplies and nutritional conditions in Tanzania clearly shows that the country faces nutritional problems; protein energy malnutrition is the most serious and requires priority action. Iron deficiency anemia, goiter, and…

  4. Services that Matter: An Overview of Childcare Services in Tamil Nadu. Monograph No. 7.

    Science.gov (United States)

    Shantha, E. V.

    This monograph describes the strengths and weaknesses of child care services in the Tamil Nadu region of India and suggests directions for the future of child care. Section 1, "Introduction," discusses the role of the government in providing support for child development, highlighting achievements of the State of Tamil Nadu. Section 2,…

  5. Work, Life and VET Participation amongst Lower-Paid Workers. NCVER Monograph Series 05/2011

    Science.gov (United States)

    Pocock, Barbara; Skinner, Natalie; McMahon, Catherine; Pritchard, Suzanne

    2011-01-01

    This monograph is the culmination of a three-year research program undertaken by the University of South Australia's Centre for Work+Life. It considers the barriers, support and benefit of vocational education and training (VET) for workers in the low-paid occupations (that is, those earning around $17 per hour). The research considered a wide…

  6. The Implementation of CETA in Ohio. R&D Monograph 44. Final Report.

    Science.gov (United States)

    Ripley, Randall B.

    This last of a series of reports on the implementation of the Comprehensive Employment and Training Act (CETA) in Ohio, from the inception of the program in 1974 through mid-1976, compares 16 of the 17 prime sponsors in the State. The monograph describes and explains patterns of influence over decisionmaking about CETA at the local level, a…

  7. The Implementation of CETA in Eastern Massachusetts and Boston. R & D Monograph 57.

    Science.gov (United States)

    Barocci, Thomas A.; And Others

    This monograph includes two reports describing the results of three years of field research on the implementation and impact of the Comprehensive Employment and Training Act (CETA) in Eastern Massachusetts. They represent a thorough and detailed study of the problems faced by prime sponsors in the initial years of CETA. The first report, CETA in…

  8. The Educational Production Function: Implications for Educational Manpower Policy. Institute of Public Employment Monograph No. 4.

    Science.gov (United States)

    Heim, John; Perl, Lewis

    This monograph summarizes and evaluates "educational production function analyses"--studies of the relation between inputs and outputs in an education system--in order to aid in educational manpower policy making. In addition, data from New York state school districts and from a large national sample of high school students is subjected to…

  9. Florida Studies in the Helping Professions. University of Florida Monographs Social Sciences--No. 37.

    Science.gov (United States)

    Combs, Arthur W.; And Others

    The monograph presents principles governing the nature and effective practice of helping professions. It is presented in three parts: (1) background of the studies and evaluation of the hypothesis, (2) research reports completed to date, (3) interpretation of the research and future directions. The research deals with perceptual organization of…

  10. Grassroots Journalism in the City: Cleveland's Neighborhood Newspapers. Monograph No. 6.

    Science.gov (United States)

    Jeffres, Leo W.; And Others

    The first section of this monograph on community newspapers describes the patterns and trends of "grassroots journalism" in the Cleveland, Ohio, area. Based on interviews with 37 newspaper editors, the following topics are covered: origins and history, goals, organization and structure, method of production, advertising, content, audience, and…

  11. Design criteria monograph for pressure regulators, relief valves, check valves, burst disks, and explosive valves

    Science.gov (United States)

    1974-01-01

    Monograph reviews and assesses current design practices, and from them establishes firm guidance for achieving greater consistency in design, increased reliability in end product, and greater efficiency in design effort. Five devices are treated separately. Guides to aid in configuration selection are outlined.

  12. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... Chemotherapy During Pregnancy; Request for Comments; Announcement of a Panel Meeting To Peer Review Draft... of the Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy... of Cancer Chemotherapy During Pregnancy, which has been prepared by the NTP Office of...

  13. Existing and Emerging Technologies in Education: A Descriptive Overview. CREATE Monograph Series.

    Science.gov (United States)

    Bakke, Thomas W.

    Second in a series of six monographs on the use of new technologies in the instruction of learning disabled students, the paper offers a descriptive overview of new technologies. Topics addressed include the following: (1) techniques for sharing computer resources (including aspects of networking, sharing information through databases, and the use…

  14. Family Support Program Quality and Parent, Family and Child Benefits. Winterberry Press Monograph Series

    Science.gov (United States)

    Dunst, Carl J.; Trivette, Carol M.; Hamby, Deborah W.

    2006-01-01

    The belief that adoption of, adherence to, and use of family support principles is associated with better parent, family, and child outcomes has for the most part gone untested but not unchallenged. This monograph investigates the relationship between practitioner adherence to family support principles and parent, family, and child behavior and…

  15. The Aeronautics Education, Research, and Industry Alliance (AERIAL) 2002 Report. UNO Aviation Monograph Series. UNOAI Report.

    Science.gov (United States)

    Bowen, Brent D.; Box, Richard C.; Fink, Mary M.; Gogos, George; Lehrer, Henry R.; Narayanan, Ram M.; Nickerson, Jocelyn S.; O'Neil, Patrick D.; Tarry, Scott E.; Vlasek, Karisa D.

    This document contains four papers on aeronautics education, research, and partnerships that partly supported through the Aeronautics Education, Research, and Industry Alliance (AERIAL). The paper "2002 AERIAL Monograph" (Brent D. Bowen, Jocelyn S. Nickerson, Mary M. Fink, et al.) presents an overview of research and development in the following…

  16. Focus on Learning: A Schoolwide Renewal Process of Analysis & Action. HSLA Monograph.

    Science.gov (United States)

    George, Marilyn; Haught, Don

    The Accrediting Commission for Schools, Western Association of Schools and Colleges (WASC) has recently developed a new protocol for accrediting schools entitled "Focus on Learning" (FoL). This monograph explains how the FoL process can influence student learning and serve as a vehicle for school improvement and accountability. The following…

  17. Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

    Science.gov (United States)

    Baan, Robert A; Grosse, Yann

    2004-09-01

    Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations

  18. Leiomyosarcoma of the colon

    Directory of Open Access Journals (Sweden)

    Janevski Vlado

    2015-01-01

    Full Text Available Introduction. Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract. Leiomyosarcomas of the gastrointestinal tract are rare mesenchymal neoplasms which grossly and histologically resemble gastrointestinal stromal tumors. They may be differentiated from gastrointestinal stromal tumors by using immunohistochemistry and they are typically positive for α smooth muscle actin and desmin and negative for c-kit, CD34 and DOG1.1. They often express calponin and h-caldesmon. Case Report. We present a case of a 59-year-old male with anemia, weight loss, intermittent abdominal pain and right abdominal mass. Colonoscopy revealed an exophytic ulcerated neoplastic mass in the ascending colon and abdominal computed tomography scan showed an ill-defined heterogeneous tumor mass which surrounded almost the whole ascending colon. The patient underwent right hemicolectomy and partial resection of ileum. Histopathological examination revealed a leiomyosarcoma composed of atypical spindle cells positive for α smooth muscle actin, desmin and vimentin, and negative for c-kit, CD34, S100 and neuron specific enolase. The patient is alive 8 months after the operation, undergoing chemotherapy. Conclusion. We have concluded that the multimodal approach comprising chemotherapy and complete surgical resection controls the leiomyosarcomas.

  19. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... Local Offices Close + - Text Size Get Tested for Colon Cancer [Video] This free video explains the most commonly ... re like most people, the thought of getting colon cancer or even going for a colon cancer test ...

  20. Explant cultures of human colon

    DEFF Research Database (Denmark)

    Autrup, Herman; Barrett, L.A.; Jackson, F.E.;

    1978-01-01

    Human colonic epithelium has been cultured as explants in a chemically defined medium for periods of 1 to 20 days. The viability of the explants was shown by the preservation of the ultrastructural features of the colonic epithelial cells and by active incorporation of radioactive precursors into...

  1. Understanding your colon cancer risk

    Science.gov (United States)

    ... what steps you can take to prevent colon cancer . Risk Factors We do not know what causes colon cancer, ... Society. Colorectal cancer: detailed guide. What are the risk factors for colorectal cancer? Available at: www.cancer.org/cancer/colonandrectumcancer/detailedguide/ ...

  2. [Irritable colon and constipation].

    Science.gov (United States)

    Meyenberger, C

    1993-04-20

    Irritable bowel syndrome is a very common clinical problem with a broad spectrum of severity. The management includes a combination of positive diagnosis of typical symptoms with limited investigations to exclude underlying structural or biochemical disorders. Therapeutic trials focus on the relief of predominant symptoms. Identification and modification of factors exacerbating symptoms, behavioural techniques and pharmacologic agents directed to the presumed gastrointestinal motor dysfunction are required. Psychological support by the physician is the most important part of treatment. Chronic constipation may be the predominant symptom of irritable bowel syndrome. Underlying organic disorders must be excluded by clinical examination and endoscopy. Severe chronic constipation requires further investigation of colonic motility and defecation. High fibre diet, osmotic laxatives and procinetic agents may lead to an improvement. In rare cases surgery may be indicated. PMID:8488351

  3. Colon interposition for oesophageal replacement.

    Science.gov (United States)

    Thomas, Pascal A; Gilardoni, Adrian; Trousse, Delphine; D'Journo, Xavier B; Avaro, Jean-Philippe; Doddoli, Christophe; Giudicelli, Roger; Fuentes, Pierre

    2009-01-01

    The choice of the colon as an oesophageal substitute results primarily from the unavailability of the stomach. However, given its durability and function, colon interposition keeps elective indications in patients with benign or malignant oesophageal disease who are potential candidates for long survival. The choice of the colonic portion used for oesophageal reconstruction depends on the required length of the graft, and the encountered colonic vascular anatomy, the last being characterised by the near-invariability of the left colonic vessels, in contrast to the vascular pattern of the right side of the colon. Accordingly, the transverse colon with all or part of the ascending colon is the substitute of choice, positioned in the isoperistaltic direction, and supplied either from the left colic vessels for long grafts or middle colic vessels for shorter grafts. Technical key points are: full mobilisation of the entire colon, identification of the main colonic vessels and collaterals, and a prolonged clamping test to ensure the permeability of the chosen nourishing pedicle. Transposition through the posterior mediastinum in the oesophageal bed is the shortest one and thereby offers the best functional results. When the oesophageal bed is not available, the retrosternal route is the preferred alternative option. The food bolus travelling mainly by gravity makes straightness of the conduit of paramount importance. The proximal anastomosis is a single-layer hand-fashioned end-to-end anastomosis to prevent narrowing. When the stomach is available, the distal anastomosis is best performed at the posterior part of the antrum for the reasons of pedicle positioning and reflux prevention, and a gastric drainage procedure is added when the oesophagus and vagus nerves have been removed. In the other cases, a Roux-en-Y jejunal loop is preferable to prevent bile reflux into the colon. Additional procedures include re-establishment of the colonic continuity, a careful closure of

  4. OAPEN-UK: an Open Access Business Model for Scholarly Monographs in the Humanities and Social Sciences

    OpenAIRE

    Milloy, Caren; Stone, Graham; Collins, Ellen

    2012-01-01

    This paper presents the current findings of OAPEN-UK, a UK research project gathering evidence on the social and technological impacts of an open access business model for scholarly monographs in the humanities and social sciences.

  5. OAPEN-UK: an Open Access Business Model for Scholarly Monographs in the Humantiies and Social Sciences

    OpenAIRE

    Milloy, C.; Stone, G; Collins, E.

    2012-01-01

    This paper presents the initial findings of OAPEN-UK, a UK research project gathering evidence on the social and technological impacts of an open access business model for scholarly monographs in the humanities and social sciences.

  6. Colonic lymphangiomatosis associated with anemia

    Institute of Scientific and Technical Information of China (English)

    Woo Chul Chung; Hye-Kang Kim; Jin Young Yoo; Jeong Rok Lee; Kang-Moon Lee; Chang Nyol Paik; U-Im Jang; Jin Mo Yang

    2008-01-01

    lymphangioma is an uncommon malformation of lymphatic system.Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease.Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment,resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain,bleeding,intussusceptions.We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia,which was diagnosed and treated with endoscopic snare polyperctomy.

  7. Colonic lymphangiomatosis associated with anemia

    Directory of Open Access Journals (Sweden)

    Woo Chul Chung, Hye-Kang Kim, Jin Young Yoo, Jeong Rok Lee, Kang-Moon Lee, Chang Nyol Paik, U-Im Jang, Jin Mo Yang

    2008-10-01

    Full Text Available Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia, which was diagnosed and treated with endoscopic snare polypectomy.

  8. On the Rise of Bayesian Econometrics after Cowles Foundation Monographs 10, 14

    OpenAIRE

    Basturk, Nalan; Cakmakli, Cem; Ceyhan, Pinar; Dijk, Herman

    2014-01-01

    This paper starts with a brief description of the introduction of the likelihood approach in econometrics as presented in Cowles Foundation Monographs 10 and 14. A sketch is given of the criticisms on this approach mainly from the first group of Bayesian econometricians. Publication and citation patterns of Bayesian econometric papers are analyzed in ten major econometric journals from the late 1970s until the first few months of 2014. Results indicate a cluster of journals with theoretical a...

  9. Monographs on Croats in Vojvodina from 1990 to 2008 - basic information

    Directory of Open Access Journals (Sweden)

    Tomislav Žigmanov

    2009-07-01

    Full Text Available The aim of the paper is to present the monograph publications on Croats in Vojvodina from 1990 to 2008. The paper presents a list of 137 monographs published in the above period that are thematically related to the social and cultural life of Croats in Vojvodina. These works are of heterogenic nature by a series of features - ranging from their volume through the complexity and scope of the theme to their scientific relevance; nevertheless, what brings them all together is the same topic. The list of publications on Vojvodina Croats is published in a sequence that follows the classification in accordance with the Universal Decimal Classification and the alphabetic list of authors. Anonymous publications and publications with multiple authors are listed at the beginning. In addition, the paper contains a brief analysis of the place of publishing and the place of the author’s activity, the language of publication and the field of science and the topics they cover. The contribution of the paper lies in the compilation of a time-defined regional bibliography that has presented for the first time all the known monographs on Vojvodina Croats in the mentioned period.

  10. Colon Cleansing: Health or Hype?

    Science.gov (United States)

    ... Testing? Bugging my dad to save his life Music Therapy Helps People With Cancer Diary of a colon ... Cancer Patients Health Literacy Tests Underutilized; May Improve Elderly Cancer Patients’ Care and Outcomes Majority of Nurses ...

  11. General Information about Colon Cancer

    Science.gov (United States)

    ... for information about colorectal cancer in children. Health history can affect the risk of developing colon cancer. ... through. This procedure is called a colostomy. A bag is placed around the stoma to collect the ...

  12. Colonization and environment

    International Nuclear Information System (INIS)

    It stands out the man's paper in the deterioration of the soil and in the phenomenon of the desertization, the conflicts of the use of the soil in the country and the underestimate that it is made of this resource in the environmental analysis. The man's relationships are discussed with the earth and the problem of the soils of the Colombian Orinoquia is examined in terms of the excess of toxic elements as To the, Fe and Mn and the other elements like P, S, Ca, Mg, K, B, and Zn. It is examined the degradation and poverty of the organic complex of the soil, the physical degradation and chemistry and their susceptibility to the erosion, as well as the excess conditions and deficit of humidity. It is recognized that it lacks calibration of the analytic methods for the soils oxisoils of the Orinoquia and the Amazonia. The importance of the soils of the humid tropic is stood out as seat of colonization that have failed when not having an appropriate technology for its handling that it forces to undertake systems of migratory agriculture and to the transformation of the forest in prairie, phenomenon that comes accompanied by the degradation of the soils, illicit cultivations, social conflicts and alteration of the essential ecological processes for the survival

  13. Colon polyps and cancer.

    Science.gov (United States)

    Kronborg, O

    2004-01-01

    Screening for colorectal neoplasia still is the best method of reducing the mortality due to colorectal cancer, and it is to be hoped that fecal occult blood test programs will expand in the near future and be combined with appropriate endoscopy. There are substantial problems with compliance in large programs with occult blood tests as well as endoscopy. Colonography and DNA testing in feces are not yet suitable for population screening. Diagnostic strategies in symptomatic patients are becoming more selective, in the hope of avoiding many superfluous examinations without increasing the risk of missing cancers. New results have confirmed the preventive effect of long-term aspirin use on adenoma recurrence, but the most cost-effective dosage is not clear; the mechanism of action is also uncertain, but seems to involve cyclooxygenase-2. The risk of adenomas does not appear to be associated with low consumption of folate, but with low intake of fiber. A number of biomarkers have been evaluated in polyp patients, but so far surveillance is still based on endoscopic experience, which is less than optimal. Attempts have been made to restrict the number of surveillance endoscopies and reduce the pathologist's workload. The place of argon plasma coagulation has been clearly defined in connection with piecemeal removal of large sessile adenomas. Advances have been achieved in surgery and radiotherapy for rectal cancer, and acute surgery for colonic cancer with severe obstruction will be less common after the introduction of the metal stent. PMID:14722849

  14. Colonization and environment

    International Nuclear Information System (INIS)

    The environmental results of the colonization, process and their consequences are analyzed in the local, national and international order, the activities through which the acts on the means and the nature of these. It is examined the meaning of the sustainable development, the phenomenon of the exhaustion of the ecosystems and their responsible ones. It discusses the importance of the Orinoquia in the mark of the environmental problems in the international order, the region has been intensely exploded by means of intensive production systems, what has led to the exhaustion of these areas in the world environment. The colonist's paper is exposed in the environmental deterioration, in front of the function of the tropical humid forest and it confirms a focus that it approaches the environmental problem from a perspective that makes emphasis in the social component of that problem, in opposition to the conservators where the ecosystem is the only valid reason and the social groups that intervene him, they should simply disappear. It is necessary the necessity to focus of integral way, the colonist's nature like element of a social group, the list that completes in the mark of the nation and their development model, the political economic system and the nationality inside which makes their economic decisions and of production. It is recognized that they are not enough solutions of technical order to impact on the use and sustainable handling of the Orinoquia, but rather it should be contemplated the economic, social, environmental and political aspects of the problem simultaneously, as well as the growing and resolved participation of the social group in their group

  15. Therapeutic Management of Colon Cancer

    Directory of Open Access Journals (Sweden)

    Ana-Maria Todosi

    2014-09-01

    Full Text Available Colorectal cancer is a major public health problem worldwide, and a major cause of mortality and morbidity. Correct pretherapeutic staging has the role of guiding the management of colon cancer patients. The diagnosis is guided by the clinical symptoms. Chemotherapy is an important part of colon cancer treatment. Chemotherapy regimens are adapted to tumor stage and patient status and have various side effects and variable survival outcomes. International guidelines recommend different treatments depending on the presence or absence of metastases. The primary goal of treatment in nonmetastatic colon cancer is surgical removal of the tumor which could be the first step of the complex therapy or preceded by neoadjuvant therapy, depending on pretherapeutic staging. In resectable nonmetastatic tumors the preferred surgical procedure is colectomy with en bloc removal of regional lymph nodes. The extent of colectomy should be based on tumor location. The management of metastatic colon cancer also targets the therapeutic approach of the metastatic disease. Therapy is standardized and applied according to tumor stage. Surveillance has a major role in therapeutic success, reason why a time schedule and a protocol adapted to the primary lesion are essential. The goal of implementing the recommendations of international guidelines for the treatment of colon cancer is to provide a uniform treatment for this disease in view of improving overall survival of patients.

  16. Neurological manifestation of colonic adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Uzair Chaudhary

    2012-04-01

    Full Text Available Paraneoplastic neurologic disorders are extremely rare in cancer patients and are most commonly associated with certain tumors, such as ovarian cancer, small cell lung cancer, and breast cancer. We report here a paraneoplastic neurological syndrome in a 53-year-old man with colonic adenocarcinoma with a solitary liver metastasis. His paraneoplastic syndrome was successfully treated by methylprednisolone and primary oncologic therapies including neoadjuvant chemotherapy and definitive surgery. This is also the first documented case of simultaneous manifestation of a sensory neuropathy and limbic encephalitis with colon cancer.

  17. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... examine the lining by filling the colon with air or with an x-ray blocking liquid and ... virtual colonoscopy. The radiologist fills your colon with air then scans it. The advantages: the procedure takes ...

  18. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... power to keep colon cancer out of your life. Let me tell you how. Most colon cancers ... the cancer and going on with a normal life. More good news: you have many choices of ...

  19. Breast and Colon Cancer Family Registries

    Science.gov (United States)

    The Breast Cancer Family Registry and the Colon Cancer Family Registry were established by the National Cancer Institute as a resource for investigators to use in conducting studies on the genetics and molecular epidemiology of breast and colon cancer.

  20. Colon Cancer Rising in People Under 50

    Science.gov (United States)

    ... nlm.nih.gov/medlineplus/news/fullstory_159004.html Colon Cancer Rising in People Under 50 Incidence up more ... TUESDAY, May 24, 2016 (HealthDay News) -- Although overall colon cancer rates are declining, the rates among Americans under ...

  1. STUDIES OF DBP-INDUCED COLON CANCER

    Science.gov (United States)

    Induction of colon carcinomas by trihalomethanes in rats may be relevant to epidemiological findings of increased incidences of colon-rectal cancer associated with exposure to chlorination byproducts. These studies have demonstrated that the brominated THMs in drinking water ind...

  2. Drugs Approved for Colon and Rectal Cancer

    Science.gov (United States)

    ... Professionals Questions to Ask about Your Treatment Research Drugs Approved for Colon and Rectal Cancer This page ... and rectal cancer that are not listed here. Drugs Approved for Colon Cancer Avastin (Bevacizumab) Bevacizumab Camptosar ( ...

  3. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... a look at the entire colon. While some family doctors and internists perform colonoscopy, the test is ... be used whenever possible. If you have a family history of colon cancer or if you have ...

  4. Five New Genes Linked to Colon Cancer

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159556.html Five New Genes Linked to Colon Cancer But researchers say it's ... 2016 (HealthDay News) -- Scientists have identified five new gene mutations that may be tied to colon cancer. ...

  5. Colonic urticaria pattern due to early ischemia

    International Nuclear Information System (INIS)

    The unusual radiographic pattern of bleb-like mounds on the surface of the colon mucosa, previously described as colonic urticaria, was seen in 3 patients in whom no allergic state was present. This urticaria-like pattern was due to colonic distention in all 3, and represented only submucosal edema on the gross and microscopic specimens. We hypothesize that this pattern is due to early changes of ischemia caused by colon distention. (orig.)

  6. Vitamin D and colon cancer

    Institute of Scientific and Technical Information of China (English)

    Lidija; Klampfer

    2014-01-01

    Calcitriol, 1α, 25-dihydroxyvitamin D3(1,25(OH)2D3), the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. In agreement, the levels of vitamin D3 appear to be an essential determinant for the development and progression of colon cancer and supplementation with vitamin D3 is effective in suppressing intestinal tumorigenesis in animal models. Vitamin D3 has been estimated to lower the incidence of colorectal cancer by 50%, which is consistent with the inverse correlation between dietary vitamin D3 intake or sunlight exposure and human colorectal cancer. Several studies confirmed that increasing vitamin D3 lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D3 are associated with better overall survival of colon cancer patients. Vitamin D regulates the homeostasis of intestinal epithelium by modulating the oncogenic Wnt signaling pathway and by inhibiting tumor-promoting inflammation. Both activities contribute to the ability of 1,25D3 to prevent the development and progression of colon cancer.

  7. Le monde du theatre: monographie relative au montage d'une piece de theatre (The World of Theater: Monograph on Mounting a Theatrical Production).

    Science.gov (United States)

    Bokor, Pierre

    This monograph (in French) provides Alberta teachers with information relating to teaching about the world of the theater, and discusses the principal elements to be considered in mounting a theatrical production. It is intended for French language dramatic arts teachers (both in immersion courses and French-speaking schools). The monograph's four…

  8. Data Sources for Trait Databases: Comparing the Phenomic Content of Monographs and Evolutionary Matrices

    Science.gov (United States)

    Dececchi, T. Alex; Mabee, Paula M.; Blackburn, David C.

    2016-01-01

    Databases of organismal traits that aggregate information from one or multiple sources can be leveraged for large-scale analyses in biology. Yet the differences among these data streams and how well they capture trait diversity have never been explored. We present the first analysis of the differences between phenotypes captured in free text of descriptive publications (‘monographs’) and those used in phylogenetic analyses (‘matrices’). We focus our analysis on osteological phenotypes of the limbs of four extinct vertebrate taxa critical to our understanding of the fin-to-limb transition. We find that there is low overlap between the anatomical entities used in these two sources of phenotype data, indicating that phenotypes represented in matrices are not simply a subset of those found in monographic descriptions. Perhaps as expected, compared to characters found in matrices, phenotypes in monographs tend to emphasize descriptive and positional morphology, be somewhat more complex, and relate to fewer additional taxa. While based on a small set of focal taxa, these qualitative and quantitative data suggest that either source of phenotypes alone will result in incomplete knowledge of variation for a given taxon. As a broader community develops to use and expand databases characterizing organismal trait diversity, it is important to recognize the limitations of the data sources and develop strategies to more fully characterize variation both within species and across the tree of life. PMID:27191170

  9. Classic articles and workbook: EPRI monographs on simulation of electric power production

    International Nuclear Information System (INIS)

    This monograph republishes several articles including a seminal one on probabilistic production costing for electric power generation. That article is given in the original French along with a English translation. Another article, written by R. Booth, gives a popular explanation of the theory, and a workbook by B. Manhire is included that carries through a simple example step by step. The classical analysis of non-probabilistic generator dispatch by L.K. Kirchmayer is republished along with an introductory essay by J.P. Stremel that puts in perspective the monograph material. The article in French was written by H. Baleriaux, E. Jamoulle, and Fr. Linard de Guertechin and first published in Brussels in 1967. It derived a method for calculating the expected value of production costs by modifying a load duration curve through the use of probability factors that account for unplanned random generator outages. Although the paper showed how pump storage plants could be included and how linear programming could be applied, the convolution technique used in the probabilistic calculations is the part most widely applied. The tutorial paper by Booth was written in a light style, and its lucidity helped popularize the method. The workbook by Manhire also shows how the calculation can be shortened significantly using cumulants to approximate the load duration curve

  10. Bibliometric analysis of martial arts monographs published in Spain (1906-2006

    Directory of Open Access Journals (Sweden)

    Mikel Pérez Gutiérrez

    2012-07-01

    Full Text Available This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008, the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (karate, judo/jujutsu, taijiquan, wu-shu/kung fu, classics, qigong, philosophy, history and education, and aikido, with two patterns of bibliographic evolution appearing. The first, represented by Japanese martial arts considered as a group and martial arts focused on the utilitarian and/or sporting performance aspects (judo/jujutsu, karate and wu-shu/kung fu, developed increasingly until the 80’s when it followed a steady-state and/or drop. The second model, which characterises the Chinese martial arts group and martial arts mainly focused on healthy and/or spiritual aspects of training (taijiquan, qigong, aikido, has increased significantly from the 90’s until the present moment. The interpretation of these patterns and the evolution of the martial arts bibliographic production in Spain highlights some aspects such as the development of the Spanish society and sports practice, bibliographic production, reading habits, or the cultural influences of eastern countries on Spain.

  11. Regulation of medicinal plants for public health--European community monographs on herbal substances.

    Science.gov (United States)

    Knöss, Werner; Chinou, Ioanna

    2012-08-01

    The European legislation on medicinal products also addresses the medicinal use of products originating from plants. The objective of the legislation is to ensure the future existence of such products and to consider particular characteristics when assessing quality, efficacy, and safety. Two categories are defined: i) herbal medicinal products can be granted a marketing authorisation; and ii) traditional herbal medicinal products can be granted a registration based on their longstanding use if they are complying with a set of provisions ensuring their safe use. The Committee on Herbal Medicinal Products (HMPC) was established at the European Medicines Agency (EMA) to provide monographs and list entries on herbal substances and preparations thereof. Meanwhile, approx. 100 monographs have been published, which define a current scientific and regulatory standard for efficacy and safety of herbal substances and herbal preparations used in medicinal products. This harmonised European standard will facilitate the availability and adequate use of traditional herbal medicinal products and herbal medicinal products within the European Union. Consequent labelling shall also enable patients and health care professionals to differentiate medicinal products from other product categories like cosmetics, food supplements, and medical devices. PMID:22618374

  12. IARC Monographs

    DEFF Research Database (Denmark)

    Pearce, Neil E; Blair, Aaron; Vineis, Paolo;

    2015-01-01

    ' failures to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans. OBJECTIVES: The authors of this paper are scientists from various disciplines relevant to the identification and hazard evaluation of human......BACKGROUND: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups...... employed by IARC to assemble Working Groups of scientists from the various discipline and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by...

  13. Colonic protein fermentation and promotion of colon carcinogenesis by thermolyzed casein.

    OpenAIRE

    Corpet, Denis; Yin, Y; X. M. Zhang; Rémésy, C.; Stamp, D; Medline, A; Thompson, L.U.; Bruce, W R; Archer, M.C.

    1995-01-01

    Thermolyzed casein is known to promote the growth of aberrant crypt foci (ACF) and colon cancer when it is fed to rats that have been initiated with azoxymethane. We speculated that the promotion was a consequence of increased colonic protein fermentation (i.e., that the thermolysis of the casein decreases its digestibility, increases the amount of protein reaching the colon, and increases colonic protein fermentation and that the potentially toxic products of this fermentation promote colon ...

  14. Colonic Protein Fermentation and Promotion of Colon Carcinogenesis by Thermolyzed Casein

    OpenAIRE

    Corpet, Denis E; Rémésy, Christian; Medline, Alan; Thompson, Lilian; Bruce, W. Robert; Archer, Michael C.

    1995-01-01

    Thermolyzed casein is known to promote the growth of aberrant crypt foci (ACF) and colon cancer when it is fed to rats that have been initiated with azoxymethane. We speculated that the promotion was a consequence of increased colonic protein fermentation (i.e., that the thermolysis of the casein decreases its digestibility, increases the amount of protein reaching the colon, and increases colonic protein fermentation and that the potentially toxic products of this fermentation promote colon ...

  15. Adult Intussusception Due to a Colonic Lipoma

    Directory of Open Access Journals (Sweden)

    AR Poormazar

    2007-07-01

    Full Text Available Colonic lipoma is a benign neoplasm that can lead to colonic obstruction but concomitant intussusception is rare in adults. In this case, colocolic intussusception due to a lipoma in the descending colon had occurred. By laparatomy, we diagnosed the problem , but reduction was impossible . So resection of the colon with mass was done and anastomosed. After surgery and 3 years follow up the patient was without any complications. We present this case, and briefly review literature of colonic intussusception in adults.

  16. Medullary carcinoma of the colon

    DEFF Research Database (Denmark)

    Fiehn, Anne-Marie Kanstrup; Grauslund, Morten; Glenthøj, Anders;

    2015-01-01

    Medullary carcinoma of the colon is a rare variant of colorectal cancer claimed to have a more favorable prognosis than conventional adenocarcinomas. The histopathologic appearance may be difficult to distinguish from poorly differentiated adenocarcinoma. The study aimed to evaluate the diagnostic...... interobserver agreement and to characterize the immunohistochemical and molecular differences between these two subgroups. Fifteen cases initially classified as medullary carcinoma and 30 cases of poorly differentiated adenocarcinomas were included. Two pathologists reviewed the slides independently without...... differences in CK20 (p = 0.005) expression and in the rate of BRAF mutations (p = 0.0035). In conclusion, medullary carcinomas of the colon are difficult to discriminate from poorly differentiated adenocarcinoma even with the help of immunohistochemical and molecular analyses. This raises the question whether...

  17. Covering the '76 Elections: A Dialogue between Journalists and Social Scientists. Columbia Journalism Monograph No. 2, 1976.

    Science.gov (United States)

    Levy, Mark R., Ed.

    The purpose of the conference of journalists and social scientists "Covering the '76 Elections: A Dialogue..." was to provide an opportunity to discuss academic research on elections and to expose the social science community to the thinking and concerns of journalists. This monograph contains the conference keynote address by Henry F. Graff; five…

  18. Community Collaboration for Improving Career Guidance Programs: Preliminary Findings Suggest It Can Work. A Monograph and an Evaluation Auditor's Report.

    Science.gov (United States)

    Jones, G. Brian; And Others

    Community collaboration for improving career guidance is an attempt to obtain cooperation from local agencies, organizations, and volunteering individuals to provide assistance to citizens whose career needs are not being addressed. This monograph is designed to motivate and provide initial orientation for community leaders who want to develop…

  19. Youth with Disabilities in the Corrections System: Prevalence Rates and Identification Issues. Monograph Series on Education, Disability and Juvenile Justice.

    Science.gov (United States)

    Rutherford, Robert B., Jr.; Bullis, Michael; Anderson, Cindy Wheeler; Griller-Clark, Heather M.

    This monograph, one of a series on youth with disabilities and the juvenile justice system, reviews current data on disabilities requiring special education and related supports. Statistics on the prevalence of juvenile crime are followed by statistics on the prevalence of special education disabilities in the system, specifically specific…

  20. First-Year Academic Advising: Patterns in the Present, Pathways to the Future. Monograph Series Number 18.

    Science.gov (United States)

    Upcraft, M. Lee, Ed.; Kramer, Gary L., Ed.

    This monograph is designed to provide a blueprint to educators on how to improve academic advising for first-year college students. Seventeen chapters are: (1) "First-Year Students: The Year 2000" (Wesley Habley); (2) "Insights from Theory: Understanding First-Year Student Development" (M. Lee Upcraft); (3) "Creating Successful Transitions Through…

  1. The Origins of Local News in the U. S. Country Press, 1840s-1970s. Journalism Monographs Number 65.

    Science.gov (United States)

    Russo, David J.

    The origins of local news in the United States country press between the 1840s and 1870s are discussed and traced in this monograph. Specifically, it deals with why local news reporting in standardized form began when it did, who provided the news, and what the news items revealed about the patterns of life in rural areas and towns in the United…

  2. Why Is My Child Hurting? Positive Approaches to Dealing with Difficult Behaviors. A Monograph for Parents of Children with Disabilities.

    Science.gov (United States)

    Lehr, Susan; Lehr, Robert

    This monograph aims to assist parents in dealing with behavior problems of children with disabilities. It begins with a case history of an 8-year-old girl with learning disabilities, emotional problems, and behavior problems and her parents' advocacy efforts to obtain an appropriate educational environment for her. Aversive interventions are…

  3. Fundamentos Basicos de Career Education. Monografia en Career Education. [Basic Fundamentals of Career Education. Monograph in Career Education].

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    This document is the Spanish translation of ED 145 222, A Primer for Career Education. In this monograph, a view of the basic nature of the career education effort is discussed under the following topics: the basis of need for career education; the meaning and goals of career education; the difference between career education and vocational…

  4. Youth in Turmoil. America's Changing Youth Cultures and Student Protest Movements. Crime and Delinquency Issues: A Monograph Series.

    Science.gov (United States)

    Douglas, Jack D.

    In this monograph, student protests and disturbances are viewed within a broad and well-informed framework, which includes: (1) the growing importance of youth and college students in American society; (2) the changing social position of youth and the rise of a generalized youth subculture; and (3) perspectives on cooperative subcultures, deviant…

  5. Colonic perforation in Behcet's syndrome

    Institute of Scientific and Technical Information of China (English)

    Catherine M Dowling; Arnold DK Hill; Carmel Malone; John J Sheehan; Shona Tormey; Kieran Sheahan; Enda McDermott; Niall J O'Higgins

    2008-01-01

    A 17-year-old gentleman was admitted to our hospital for headache, the differential diagnosis of which included Behcet's syndrome (BS). He developed an acute abdomen and was found to have air under the diaphragm on erect chest X-ray. Subsequent laparotomy revealed multiple perforations throughout the colon. This report describes an unusual complication of Behcets syndrome occurring at the time of presentation and a review of the current literature of reported cases.

  6. Laparoscopic surgery for colon cancer

    OpenAIRE

    Millo, Paolo; Rispoli, Corrado; Rocco, Nicola; Contul, Riccardo Brachet; Fabozzi, Massimiliano; Grivon, Manuela; Nardi, Mario Junior; Allieta, Rosaldo

    2013-01-01

    Colon cancer is a major problem in Western countries and complete surgical resection is the main treatment. Since its introduction the laparoscopic approach has been used to achieve bowel resection with a better postoperative course and better aesthetic outcomes. Initial concerns about the radicality of the resection and the oncologic outcomes have been overcome in the last decade. All over the world large trials have been conducted to compare the laparoscopic approach and the traditional lap...

  7. Solar thermal power technologies. Monograph in the framework of the VLEEM Project

    International Nuclear Information System (INIS)

    : technology and socio-economic development and one horizontal field of research, i.e. modelling. The technology development research programme has focussed on a selected number of new and innovative energy supply and demand technologies for which monographs have been compiled first. This report discusses the status of different Solar Thermal Power technologies (STP). The report serves as monograph document for very long modelling exercise in the VLEEM project and focuses on global energy supply and demand until 2100. It is difficult to make predictions about the development of these technologies for such a timeframe. Because the VLEEM project focuses on technical options, this monograph pays attention to the expected breakthrough year of 'new' power production facilities, geographical spread, energy payback ratios and land, water and material needs

  8. Primary lymphoma of the colon

    Directory of Open Access Journals (Sweden)

    Tauro Leo

    2009-01-01

    Full Text Available Primary lymphoma of the colon is a rare tumor of the gastrointestinal (GI tract and comprises only 0.2-1.2% of all colonic malignancies. The most common variety of colonic lymphoma is non-Hodgkin′s lymphoma (NHL. The GI tract is the most frequently involved site, accounting for 30-40% of all extra nodal lymphomas, approximately 4-20% of which are NHL. The stomach is the most common location of GI lymphomas, followed by the small intestine. Early diagnosis may prevent intestinal perforation; however, the diagnosis is often delayed in most cases. Therapeutic approaches described in two subsets include: Radical tumor resection (hemicolectomy plus multi-agent chemotherapy (polychemotherapy in early stage patients, biopsy plus multidrug chemotherapy in advanced stage patients. Radiotherapy is reserved for specific cases; surgery alone can be considered as an adequate treatment for patients with low-grade NHL disease that does not infiltrate beyond the sub mucosa. Although resection plays an important role in the local control of the disease and in preventing bleeding and/or perforation, it rarely eradicates the lymphoma by itself. Those with limited stage disease may enjoy prolonged survival when treated with aggressive chemotherapy.

  9. Ayağın sesamoid ve aksesuar kemikleri

    OpenAIRE

    Esenkaya, Irfan; Nalbantoglu, Ufuk; Gorgec, Mucahit; Gurkaynak, Gokhan

    2004-01-01

    ln a normaI foot, there are two types of bones that remain unattached to the main body of any bone. These are the sesamoid and accessory bones. The female patient aged 54 years consulted at the Haydarpaşa Numune State Hospital, Orthopaedics and Traumatology outpatient department, in İstanbul. She complained of abducting the forefoot with weight bearing in the year of 1992. In the orthopaedic and radiologic examination of the case, besides flattening of the medial curve, in addition to the nor...

  10. Day residue and screen memory in Freud's dream of the botanical monograph.

    Science.gov (United States)

    Palombo, S R

    1988-01-01

    Freud's theory of dream construction allowed the censorship to intervene only when a repressed infantile wish emerged from the unconscious. In his (1899) paper on screen memories, however, he proposed a mechanism for the defensive displacement of current events as they are sorted for introduction into permanent memory. I suggest that Freud was actually describing the conflictual process through which the day residue of the dream is formed. Day residue and screen memory are closely related as elements of the dreamer's present and past experience displaced from his more central instinctual concerns. Freud's dream of the botanical monograph clearly illustrates this relation. Substituted day residues were matched in the dream with relatively innocuous memories of past events of similar cognitive and affective significance. By retracing the substitutions, one can see how a current conflict over Fliess's role in the writing of the dream book recapitulated a series of Freud's earlier conflicts concerning his father and the power of books. PMID:3235760

  11. Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic inflammation caused by chronic nfections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph Snodes, skin, respiratory tract, adrenal gland, vagina and brain. We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver.Colonoscopy revealed a large malignant-appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon. Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma.Histological examination of two of the other polyps revealed malakoplakia which was characterized by aggregates of granular histiocytes with Michaelis-Gutmann bodies and histochemically confirmed with periodic acid-Schiff and von Kossa stains. This is a rare case diagnosed on endoscopic samples. The majority of reported cases were found in surgical specimens. In addition, the endoscopic appearance of multiple polyps is unusual in malakoplakia.

  12. The colon: Absorptive, seccretory and metabolic functions.

    Science.gov (United States)

    Cummings, J G

    1975-01-01

    The role which the human colon fulfils in digestion and metabolism remains largely undocumented. Its capacity to conserve water and electrolytes is well known although how this is controlled is uncertain. In the animal kingdom, calcium and magnesium absorption from the colon are improtant as are absorption and synthesis of vitamins. The abundant microflora of the human colon gives it unique properties. Dietary residue is metabolised forming short-chain fatty acids, hydrogen, carbon dioxide and methane; whilst 20% of urea synthesised in man is broken down in the colon to ammonia, which is reabsorbed, and carbonic acid. The microflora also degrades a wide variety of organic compounds including food additives, drugs, bile salts, and cholesterol which may be relevant to the development of colon cancer. Regional differences in colonic function also exist making interpretation of data from this relatively inaccessible organ more difficult. PMID:1205009

  13. Colon Cancer Metastatic to the Biliary Tree.

    Science.gov (United States)

    Strauss, Alexandra T; Clayton, Steven B; Markow, Michael; Mamel, Jay

    2016-04-01

    Metastasis of colon adenocarcinoma is commonly found in the lung, liver, or peritoneum. Common bile duct (CBD) tumors related to adenomas from familial adenomatous polyposis metastasizing from outside of the gastrointestinal tract have been reported. We report a case of biliary colic due to metastatic colon adenocarcinoma to the CBD. Obstructive jaundice with signs of acalculous cholecystitis on imaging in a patient with a history of colon cancer should raise suspicion for metastasis to CBD. PMID:27144209

  14. Quantitative measurement of feline colonic transit

    International Nuclear Information System (INIS)

    Colonic transit scintigraphy, a method for quantitatively evaluating the movement of the fecal stream in vivo, was employed to evaluate colonic transit in the cat. Scintigraphy was performed in duplicate in five cats and repeated four times in one cat. After instillation of an 111In marker into the cecum through a surgically implanted silicone cecostomy tube, colonic movement of the instillate was quantitated for 24 h using gamma scintigraphy. Antegrade and retrograde motion of radionuclide was observed. The cecum and ascending colon emptied rapidly, with a half-emptying time of 1.68 +/- 0.56 h (mean +/- SE). After 24 h, 25.1 +/- 5.2% of the activity remained in the transverse colon. The progression of the geometric center was initially rapid, followed later by a delayed phase. Geometric center reproducibility was found to be high when analyzed using simple linear regression (slope = 0.92; r = 0.73; P less than 0.01). Atropine (0.1 mg/kg im) was found to delay cecum and ascending colon emptying and delay progression of the geometric center. These results demonstrate both 1) the ability of colonic transit scintigraphy to detect changes in transit induced by pharmacological manipulation and 2) the fact that muscarinic blockade inhibits antegrade transit of the fecal stream. We conclude that feline colonic transit may be studied in a quantitative and reproducible manner with colonic transit scintigraphy

  15. Muscarinic Receptor Signaling in Colon Cancer

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Raufman

    2011-03-01

    Full Text Available According to the adenoma-carcinoma sequence, colon cancer results from accumulating somatic gene mutations; environmental growth factors accelerate and augment this process. For example, diets rich in meat and fat increase fecal bile acids and colon cancer risk. In rodent cancer models, increased fecal bile acids promote colon dysplasia. Conversely, in rodents and in persons with inflammatory bowel disease, low-dose ursodeoxycholic acid treatment alters fecal bile acid composition and attenuates colon neoplasia. In the course of elucidating the mechanism underlying these actions, we discovered that bile acids interact functionally with intestinal muscarinic receptors. The present communication reviews muscarinic receptor expression in normal and neoplastic colon epithelium, the role of autocrine signaling following synthesis and release of acetylcholine from colon cancer cells, post-muscarinic receptor signaling including the role of transactivation of epidermal growth factor receptors and activation of the ERK and PI3K/AKT signaling pathways, the structural biology and metabolism of bile acids and evidence for functional interaction of bile acids with muscarinic receptors on human colon cancer cells. In murine colon cancer models, deficiency of subtype 3 muscarinic receptors attenuates intestinal neoplasia; a proof-of-concept supporting muscarinic receptor signaling as a therapeutic target for colon cancer.

  16. Granularcelletumor i colon--Abrikossoffs tumor

    DEFF Research Database (Denmark)

    Eriksen, Jens Ravn; Ibsen, Per; Gyrtrup, Hans Jørgen

    2006-01-01

    A 50-year-old woman had a right hemicoletomy due to a large sessile polyp in the ascending colon, inappropriate for polypectomy. Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT...... due to the appearance in the light microscope and immunohistochemical analysis. To our knowledge, this is the first reported case of synchronic adenoma and GCT in the colon. To date there is no evidence of any association or disposing factors between GCT in the colon and colonic adenomas or malignancy....

  17. Muscarinic Receptor Signaling in Colon Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Rosenvinge, Erik C. von, E-mail: evonrose@medicine.umaryland.edu; Raufman, Jean-Pierre [University of Maryland School of Medicine, Division of Gastroenterology & Hepatology, 22 S. Greene Street, N3W62, Baltimore, MD 21201 (United States); Department of Veterans Affairs, VA Maryland Health Care System, 10 North Greene Street, Baltimore, MD 21201 (United States)

    2011-03-02

    According to the adenoma-carcinoma sequence, colon cancer results from accumulating somatic gene mutations; environmental growth factors accelerate and augment this process. For example, diets rich in meat and fat increase fecal bile acids and colon cancer risk. In rodent cancer models, increased fecal bile acids promote colon dysplasia. Conversely, in rodents and in persons with inflammatory bowel disease, low-dose ursodeoxycholic acid treatment alters fecal bile acid composition and attenuates colon neoplasia. In the course of elucidating the mechanism underlying these actions, we discovered that bile acids interact functionally with intestinal muscarinic receptors. The present communication reviews muscarinic receptor expression in normal and neoplastic colon epithelium, the role of autocrine signaling following synthesis and release of acetylcholine from colon cancer cells, post-muscarinic receptor signaling including the role of transactivation of epidermal growth factor receptors and activation of the ERK and PI3K/AKT signaling pathways, the structural biology and metabolism of bile acids and evidence for functional interaction of bile acids with muscarinic receptors on human colon cancer cells. In murine colon cancer models, deficiency of subtype 3 muscarinic receptors attenuates intestinal neoplasia; a proof-of-concept supporting muscarinic receptor signaling as a therapeutic target for colon cancer.

  18. Muscarinic Receptor Signaling in Colon Cancer

    International Nuclear Information System (INIS)

    According to the adenoma-carcinoma sequence, colon cancer results from accumulating somatic gene mutations; environmental growth factors accelerate and augment this process. For example, diets rich in meat and fat increase fecal bile acids and colon cancer risk. In rodent cancer models, increased fecal bile acids promote colon dysplasia. Conversely, in rodents and in persons with inflammatory bowel disease, low-dose ursodeoxycholic acid treatment alters fecal bile acid composition and attenuates colon neoplasia. In the course of elucidating the mechanism underlying these actions, we discovered that bile acids interact functionally with intestinal muscarinic receptors. The present communication reviews muscarinic receptor expression in normal and neoplastic colon epithelium, the role of autocrine signaling following synthesis and release of acetylcholine from colon cancer cells, post-muscarinic receptor signaling including the role of transactivation of epidermal growth factor receptors and activation of the ERK and PI3K/AKT signaling pathways, the structural biology and metabolism of bile acids and evidence for functional interaction of bile acids with muscarinic receptors on human colon cancer cells. In murine colon cancer models, deficiency of subtype 3 muscarinic receptors attenuates intestinal neoplasia; a proof-of-concept supporting muscarinic receptor signaling as a therapeutic target for colon cancer

  19. Colonization of Crystalline Cellulose by Clostridium cellulolyticum ATCC 35319

    OpenAIRE

    Gelhaye, E.; Gehin, A; Petitdemange, H.

    1993-01-01

    Cellulose colonization by Clostridium cellulolyticum was studied by using [methyl-3H]thymidine incorporation. The colonization process indicated that a part of the bacterial population was released from cellulose to the liquid phase before binding and colonizing another adhesion site of the cellulose. We postulate that cellulose colonization occurs according to the following process: adhesion, colonization, release, and readhesion.

  20. [Serpins in hyperplastic colon tissue].

    Science.gov (United States)

    Kit, O I; Frantsiiants, E M; Kozlova, L S; Terpugov, A L

    2014-01-01

    The purpose of the study was to define α-2-macroglobulin (α-2M) and α-1-proteinase inhibitor (α-1PI) in tissues of malignant tumors and polyps of the lower parts of the colon. 28 patients had malignant tumors of the sigmoid colon or rectum (T3N0-1M0-2), 29 had polyps of the same location. Content of α-2M and α-1PI was studied in cytosols of the central, peripheral and conditionally healthy tissues (of resection line) of the mentioned hyperplasias by the ELISA method using standard test kits. Suppression of a-2M and increase of α-1PI (perifocal zone) were found in malignant tumor tissue, as well as α-1PI maintenance in tumorous focus. Increase of α-2M and decrease of α-1PI were detected in polyp tissue. Changes in physiological balance of serpins were assessed by α-1PI/α-2M ratio in comparison with the resection line. The risk of distortion of proliferation and differentiation processes increases in polyps in ineffective inhibition of proteolysis under the influence of released factors of malignancy. Endogenous or medicamentous restoration of balance of interaction of trypsin-like proteases and kallikrein with inhibitors will probably play the crucial role. PMID:25911925

  1. [Irritable colon and psychosomatic disease].

    Science.gov (United States)

    Morini, A; Mauceri, P; Pallotta, P; Pelliccia, G

    1984-08-25

    The authors, after having considered the close likeness between the collateral clinical picture described by others in regard to the irritable colon syndrome and the outstanding one pointed out by them in many cases of psychosomatic disorders, have analyzed again a large number of personal cases diagnosed as "psychosomatic" in order to find possible relations between these two unwholesome conditions. At the end of their examination, after having ascertained that the "Irritable colon" has not to be considered an isolated disease but a syndrome caused by many factors, hinged on a predisposing condition likely of constitutional nature, the authors remark how it may nest in the folds of a psychosomatic disorder and sometimes be its outbreaking feature. The authors by this way, don't want to conclude identifying the I.C. with a psychosomatic disorder and suggest that in such cases one may take this syndrome as the main manifestation of a condition marked by an impairment of the digestive tract motility inside a psychosomatic disorder with a somatic expression of this apparatus. PMID:6483246

  2. Imaging of total colonic Hirschsprung disease

    International Nuclear Information System (INIS)

    Hirschsprung disease (HD) is a functional obstruction of the bowel caused by the absence of intrinsic enteric ganglion cells. The diagnosis of total colonic HD (TCHD) based on contrast enemas is difficult in newborns because radiological findings vary. To evaluate the radiographic and contrast enema findings in patients with pathologically proven TCHD. From 1966 to 2007, 17 records from a total of 31 patients with TCHD were retrospectively evaluated for diameter and shape of the colon, diameter of the small bowel, bowel wall contour, ileal reflux, abdominal calcifications, pneumoperitoneum, filling defects, transitional zones and rectosigmoid index. Three colonic patterns of TCHD were found: microcolon, question-mark-shape colon and normal caliber colon. Additional findings included spasmodic colon, ileal reflux, delayed evacuation and abdominal calcifications. Colonic transitional zones were found in eight patients with TCHD. The diagnosis of TCHD is difficult to establish by contrast enema studies. The length of the aganglionic small bowel and the age of the patient can influence the radiological findings in TCHD. The transitional zone and the rectosigmoid index can be false-positive in TCHD. The colon can appear normal. Consider TCHD if the contrast enema study is normal but the patient remains symptomatic and other causes of distal bowel obstruction have been excluded. (orig.)

  3. Imaging of total colonic Hirschsprung disease

    Energy Technology Data Exchange (ETDEWEB)

    Stranzinger, Enno; DiPietro, Michael A.; Strouse, Peter J. [University of Michigan Health System, Section of Pediatric Radiology, Ann Arbor, MI (United States); Teitelbaum, Daniel H. [University of Michigan Health System, Section of Pediatric Surgery, Ann Arbor, MI (United States)

    2008-11-15

    Hirschsprung disease (HD) is a functional obstruction of the bowel caused by the absence of intrinsic enteric ganglion cells. The diagnosis of total colonic HD (TCHD) based on contrast enemas is difficult in newborns because radiological findings vary. To evaluate the radiographic and contrast enema findings in patients with pathologically proven TCHD. From 1966 to 2007, 17 records from a total of 31 patients with TCHD were retrospectively evaluated for diameter and shape of the colon, diameter of the small bowel, bowel wall contour, ileal reflux, abdominal calcifications, pneumoperitoneum, filling defects, transitional zones and rectosigmoid index. Three colonic patterns of TCHD were found: microcolon, question-mark-shape colon and normal caliber colon. Additional findings included spasmodic colon, ileal reflux, delayed evacuation and abdominal calcifications. Colonic transitional zones were found in eight patients with TCHD. The diagnosis of TCHD is difficult to establish by contrast enema studies. The length of the aganglionic small bowel and the age of the patient can influence the radiological findings in TCHD. The transitional zone and the rectosigmoid index can be false-positive in TCHD. The colon can appear normal. Consider TCHD if the contrast enema study is normal but the patient remains symptomatic and other causes of distal bowel obstruction have been excluded. (orig.)

  4. Inguinal lymph node metastasis of colon cancer

    Directory of Open Access Journals (Sweden)

    Sloane McGraw

    2011-01-01

    Full Text Available We present a case of adenocarcinoma of colon with unusual metastasis to inguinal lymph nodes. Our patient is a young male with bilateral inguinal lymphadenopathy, bone pains, and jaundice who presented as carcinoma of unknown primary. He was diagnosed as widely metastatic adenocarcinoma of colon for which he received chemotherapy and has had a good response to the treatment.

  5. How researches are done in the law field? : reflections from the study of monographs of law courses in Brazil

    OpenAIRE

    Fonseca Dias, Maria Tereza

    2012-01-01

    In order to understand the impact of new technologies on the law through the science of law, it is essential to observe how Law researches are done. This paper pursues the following models of legal science: analytical (theory of formal rule); hermeneutics (interpretation theory) and empirical (decision theory) to appraise methodological procedures used in monograph researches in some Brazilian Law courses. This study was to detect which model of law science was used in the development of Law ...

  6. Duplication Cyst of the Sigmoid Colon

    Directory of Open Access Journals (Sweden)

    Bastian Domajnko

    2009-01-01

    Full Text Available A 21-year-old male with developmental delay presented with abdominal pain of two days' duration. He was afebrile and his abdomen was soft with mild diffuse tenderness. There were no peritoneal signs. Plain x-ray demonstrated a large air-filled structure in the right upper quadrant. Computed tomography of the abdomen revealed a 9×8 cm structure adjacent to the hepatic flexure containing an air-fluid level. It did not contain oral contrast and had no apparent communication with the colon. At operation, the cystic lesion was identified as a duplication cyst of the sigmoid colon that was adherent to the right upper quadrant. The cyst was excised with a segment of the sigmoid colon and a stapled colo-colostomy was performed. Recovery was uneventful. Final pathology was consistent with a duplication cyst of the sigmoid colon. The cyst was attached to the colon but did not communicate with the lumen.

  7. Congenital pouch colon - Then and now

    Directory of Open Access Journals (Sweden)

    Gupta Devendra

    2007-01-01

    Full Text Available Congenital pouch colon (CPC, a condition associated with anorectal agenesis has been reported mainly from the Indian subcontinent though there have been few case reports from other areas. The pouch differs from a normal colon structurally, histologically and functionally. The management involves a diversion colostomy at birth with or without the excision of pouch followed by pull through. This review article attempts to compile all the available literature on pouch colon along with the authors′ experience and discuss the relevant issues for proper diagnosis and management. A changing trend has been seen in the most common type of CPC seen over the years from complete congenital pouch colon that accounted for more than 70% of cases earlier to incomplete pouch colon that is more commonly seen now.

  8. Proteases of an early colonizer can hinder Streptococcus mutans colonization in vitro.

    Science.gov (United States)

    Wang, B-Y; Deutch, A; Hong, J; Kuramitsu, H K

    2011-04-01

    Streptococcus mutans is the primary cariogen that produces several virulence factors that are modulated by a competence-stimulating peptide (CSP) signaling system. In this study, we sought to determine if proteases produced by early dental plaque colonizers such as Streptococcus gordonii interfere with the subsequent colonization of S. mutans BM71 on the existing streptococcal biofilms. We demonstrated that S. mutans BM71 colonized much less efficiently in vitro on streptococcal biofilms than on Actinomyces naeslundii biofilms. Several oral streptococci, relative to A. naeslundii, produced proteases that inactivated the S. mutans CSP. We further demonstrated that cell protein extracts from S. gordonii, but not from A. naeslundii, interfered with S. mutans BM71 colonization. In addition, S. mutans BM71 colonized more efficiently on the sgc protease knockout mutant of S. gordonii than on the parent biofilms. In conclusion, proteases of early colonizers can interfere with subsequent colonization by S. mutans in vitro. PMID:21088146

  9. Towards iconic language for patient records, drug monographs, guidelines and medical search engines.

    Science.gov (United States)

    Lamy, Jean-Baptiste; Duclos, Catherine; Hamek, Saliha; Beuscart-Zéphir, Marie-Catherine; Kerdelhué, Gaetan; Darmoni, Stefan; Favre, Madeleine; Falcoff, Hector; Simon, Christian; Pereira, Suzanne; Serrot, Elisabeth; Mitouard, Thierry; Hardouin, Etienne; Kergosien, Yannick; Venot, Alain

    2010-01-01

    Practicing physicians have limited time for consulting medical knowledge and records. We have previously shown that using icons instead of text to present drug monographs may allow contraindications and adverse effects to be identified more rapidly and more accurately. These findings were based on the use of an iconic language designed for drug knowledge, providing icons for many medical concepts, including diseases, antecedents, drug classes and tests. In this paper, we describe a new project aimed at extending this iconic language, and exploring the possible applications of these icons in medicine. Based on evaluators' comments, focus groups of physicians and opinions of academic, industrial and associative partners, we propose iconic applications related to patient records, for example summarizing patient conditions, searching for specific clinical documents and helping to code structured data. Other applications involve the presentation of clinical practice guidelines and improving the interface of medical search engines. These new applications could use the same iconic language that was designed for drug knowledge, with a few additional items that respect the logic of the language. PMID:20841669

  10. Tools to Ensure Safe Medicines: New Monograph Tests in USP-NF

    Directory of Open Access Journals (Sweden)

    Catherine Sheehan

    2010-09-01

    Full Text Available This paper describes USP-NF compendial updates to six ‘high-priority” excipient monographs: Glycerin, Propylene Glycol, Sorbitol Solution, Sorbitol Sorbitan Solution, Noncrystallizing Sorbitol Solution and Maltitol Solution. The USP-NF revisions arose from the Food and DrugAdministration’s (FDA’s requests to include, as part of each monograph’s Identification test, a limit test to detect the presence of Diethylene Glycol (DEG, a toxic adulterant. These revisions alignwith the 2007 FDA Guidance for Industry: Testing of Glycerin for Diethylene Glycol (1, that drug product manufacturers perform a specific identity test for DEG on all containers of all lots ofglycerin before glycerin is used in the manufacture and preparation of drug products. This paper describes several risk factors due to a complex global excipient supply chain, nonspecific specifications, inadequate supply chain qualification, and poor understanding of regulations. Strengthening and conformance to compendial specifications is one of the tools necessary to mitigate risk and help prevent the next DEG adulteration that is part of USP’s efforts to ensure safe medicines.

  11. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate.

    Science.gov (United States)

    Dahan, Arik; Wolk, Omri; Zur, Moran; Amidon, Gordon L; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2014-06-01

    The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be high in both Caco-2 monolayers and rat intestinal perfusion studies. The main risks associated with codeine, that is, toxicity (attributed to CYP2D6 polymorphism) and its abuse potential, are present irrespective of the dosage form, and do not need to be taken into account for bioequivalence (BE) considerations. Taken together, codeine is a class 1 drug with manageable risk and is a good candidate for waiver of in vivo BE studies. PMID:24788239

  12. [Project of the historical monograph on the "Origins of Occupational Medicine Associations in the world"].

    Science.gov (United States)

    Grieco, A; Porro, A; Berti, Giuseppina Bock; Marri, G

    2003-01-01

    The present contribution regards the project of the historical monograph on the Origins of OH associations in 23 countries, and in particular the chapter on the Origins of the Italian Society of Occupational Health. The Italian chapter is aimed at studying the foundation of the Italian Society of Occupational Health (Naples, October 12, 1929, within the 8th National Congress of Occupational Health) and the first decades of its activity. On account of the complexity and variety of the scientific and social context as well as the particular political period considered, the contribution is divided into 4 different parts. The first deals with the foundation of the Italian Society of Occupational Health and its statutory organization. The second part treats the role and presence of the discipline in the university world as well as the relationships with other cultural institutions such as academies. The third part concerns the law frame (specially as to accidents and work-related diseases) within which the activity of the Italian Society of Occupational Health has started and developed. The fourth part analyses the fascist corporative system and the role played by the trade unions in promoting better life and working conditions, with common issues also with the programmes of the Italian Society of Occupational Health. Finally, some closing remarks and references are provided. PMID:14582260

  13. İlkokul Öğrencileri ve Sınıf Öğretmeni Adaylarının Doğaya İlişkin Algıları ve Sorumluluklarına Yönelik Düşünceleri Elemantary Scholl Students’ And Prospective Elemantary Scholl Teachers’ Perceptions of Nature And Thoughts of Their Responsibilities Towards The Nature

    Directory of Open Access Journals (Sweden)

    Nilüfer KÖŞKER

    2013-03-01

    Full Text Available Nature education provides important opportunities for learningabout nature, being aware of it and protecting it. The best way is tostart education of it from children. Education plays an important roleon the child in shaping his/her perceptions about nature andenvironment. Perception of people about nature affects their behaviorsand attitudes. Defining the perceptions of teachers that direct teachingprocess and students about nature and their responsibility towardsnature will be affective on the composition of nature education. The aimof this research is to define primary school students’ and prospectiveteachers’ perceptions of nature and thoughts of their responsibilitiestowards the nature. Data were collected from 150 primary schoolstudents and 123 prospective primary school teachers. Interview formswere used as data collection instrument Data were evaluated accordingto qualitative descriptive analysis and content analysis. According toresearch results, most of the primary school students define nature asplants while most of prospective primary school teachers define as aplace of life area. According to results, nature evokes those plants suchas tree and forest. Thoughts of their responsibilities towards the naturegathered under two themes: protection and greening. Most ofprospective primary school teachers and primary school students havefocused on their responsibility for protection more. It would be said thatboth students and prospective teachers pay attention to theirenvironment and their awareness level for protecting is very high. Doğayı tanımak, korumak ve farkındalık yaratmak açısından doğaeğitimi önemli fırsatlar yaratacaktır. Bu yönde bir eğitime çocuklardanbaşlamak ise en doğru adım olacaktır. Çocuğun içinde bulunduğu çevreve doğa hakkındaki algılarının şekillenmesinde eğitim belirleyici bir yertutmaktadır. Bireylerin doğaya ilişkin algıları, tutum ve davranışlarınıetkilemektedir.

  14. Colon interposition for esophageal reconstruction (esophagocoloplasty

    Directory of Open Access Journals (Sweden)

    R.M. Neagoe

    2013-09-01

    Full Text Available BACKGROUND: The colon is considered, after the stomac, a well-functioning and durable esophageal substitute. For esophageal reconstruction, an isoperistaltic colon graft is preferable because the antiperistaltic reconstruction could be associated with significant functional anomalies. AIM: The purpose of this retrospective study is to investigate the feasibility of colon interposition procedures as surgical option for esophageal reconstruction. METHODS: Between 1997 and 2012, 40 consecutive patients underwent colon interposition in our surgical department. The main indications were caustic injury and cancer of the esophagus; we reviewed clinical and operative data, intensive care unit and histopathological protocols. RESULTS: There were 24 patients (60.0% with caustic injuries of the esophagus, 13 patients with esophageal cancer (32.5% and 3 patients with other esophageal pathologies (7.5%. Ileocolon grafts were the prefered method for interposition, with the left colon graft being used mainly as a „salvage” procedure. The retrosternal route was prefered in bypass procedures; the posterior mediastinal route was applied only after curative esophagectomies. We performed hand-sewn anastomosis in the neck in all cases. One patient required microvascular surgery. The overall postoperative morbidity rate was 57.5% (n=23; the most common complications were pulmonary complications, anastomotic leakage, colon graft necrosis and late cervical anastomosis stenoses. In hospital mortality was 7.5%. CONCLUSION: Despite the high rate of postoperative morbidity, the colon interposition is a feasible procedure for esophageal reconstruction.

  15. Nutrients and Risk of Colon Cancer

    International Nuclear Information System (INIS)

    Dietary fats are thought to be important in the etiology of colon cancer. However, the evidence linking them is inconclusive. Studies on dietary protein, cholesterol and carbohydrate and the risk of colon cancer are also inconsistent. This study examined the association between dietary intake of protein, fats, cholesterol and carbohydrates, and the risk of colon cancer. Mailed questionnaires were completed by 1731 individuals with histologically confirmed cases of colon cancer and 3097 population controls between 1994 and 1997 in seven Canadian provinces. Measurements included socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire was used to provide data on eating habits from two years before the study. Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. The nutrients were categorized by quartiles based on the distributions among the controls. Intake of polyunsaturated fat, trans-fat and cholesterol were significantly associated with the risk of colon cancer; the ORs for the highest quartiles were 1.36 (95% CI, 1.02–1.80), 1.37 (95% CI, 1.10–1.71) and 1.42 (95% CI, 1.10–1.84), respectively. The association was stronger with proximal colon cancer (PCC). An increased risk was also observed with increasing intake of sucrose for both proximal and distal colon cancers; the ORs for the highest quartiles were 1.67 (95% CI, 1.22–2.29) for PCC and 1.58 (95% CI, 1.18–2.10) for distal colon cancer (DCC). An elevated risk of PCC was also found with increased lactose intake. Our findings provide evidence that a diet low in fat and sucrose could reduce the risk of various colon cancers

  16. Nutrients and Risk of Colon Cancer

    Directory of Open Access Journals (Sweden)

    Les Mery

    2010-02-01

    Full Text Available Dietary fats are thought to be important in the etiology of colon cancer. However, the evidence linking them is inconclusive. Studies on dietary protein, cholesterol and carbohydrate and the risk of colon cancer are also inconsistent. This study examined the association between dietary intake of protein, fats, cholesterol and carbohydrates, and the risk of colon cancer. Mailed questionnaires were completed by 1731 individuals with histologically confirmed cases of colon cancer and 3097 population controls between 1994 and 1997 in seven Canadian provinces. Measurements included socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire was used to provide data on eating habits from two years before the study. Odds ratios (OR and 95% confidence intervals (CI were computed using unconditional logistic regression. The nutrients were categorized by quartiles based on the distributions among the controls. Intake of polyunsaturated fat, trans-fat and cholesterol were significantly associated with the risk of colon cancer; the ORs for the highest quartiles were 1.36 (95% CI, 1.02–1.80, 1.37 (95% CI, 1.10–1.71 and 1.42 (95% CI, 1.10–1.84, respectively. The association was stronger with proximal colon cancer (PCC. An increased risk was also observed with increasing intake of sucrose for both proximal and distal colon cancers; the ORs for the highest quartiles were 1.67 (95% CI, 1.22–2.29 for PCC and 1.58 (95% CI, 1.18–2.10 for distal colon cancer (DCC. An elevated risk of PCC was also found with increased lactose intake. Our findings provide evidence that a diet low in fat and sucrose could reduce the risk of various colon cancers.

  17. Nutrients and Risk of Colon Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Jinfu, E-mail: Jinfu.hu@phac-aspc.gc.ca [Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 785 Carling Avenue, AL: 6807B, Ottawa, Ontario K1A 0K9 (Canada); La Vecchia, Carlo [Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa, 19-20156 Milan (Italy); Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Via Venezian, 1, 20133 Milan (Italy); Negri, Eva [Istituto di Ricerche Farmacologiche “Mario Negri,” Via La Masa, 19-20156 Milan (Italy); Mery, Les [Evidence and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 785 Carling Avenue, AL: 6807B, Ottawa, Ontario K1A 0K9 (Canada)

    2010-02-10

    Dietary fats are thought to be important in the etiology of colon cancer. However, the evidence linking them is inconclusive. Studies on dietary protein, cholesterol and carbohydrate and the risk of colon cancer are also inconsistent. This study examined the association between dietary intake of protein, fats, cholesterol and carbohydrates, and the risk of colon cancer. Mailed questionnaires were completed by 1731 individuals with histologically confirmed cases of colon cancer and 3097 population controls between 1994 and 1997 in seven Canadian provinces. Measurements included socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire was used to provide data on eating habits from two years before the study. Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. The nutrients were categorized by quartiles based on the distributions among the controls. Intake of polyunsaturated fat, trans-fat and cholesterol were significantly associated with the risk of colon cancer; the ORs for the highest quartiles were 1.36 (95% CI, 1.02–1.80), 1.37 (95% CI, 1.10–1.71) and 1.42 (95% CI, 1.10–1.84), respectively. The association was stronger with proximal colon cancer (PCC). An increased risk was also observed with increasing intake of sucrose for both proximal and distal colon cancers; the ORs for the highest quartiles were 1.67 (95% CI, 1.22–2.29) for PCC and 1.58 (95% CI, 1.18–2.10) for distal colon cancer (DCC). An elevated risk of PCC was also found with increased lactose intake. Our findings provide evidence that a diet low in fat and sucrose could reduce the risk of various colon cancers.

  18. Endometrial Adenocarcinoma Metastatic to the Colon Masquerading as a Primary Colon Cancer

    Directory of Open Access Journals (Sweden)

    Michael J. Anstadt

    2012-04-01

    Full Text Available While the majority of colonic malignancies represent primarytumors, secondary tumors are not uncommon. We present a case ofendometrial cancer metastatic to the colon masquerading as a primarycolonic adenocarcinoma. The clinical and pathologic characteristicsof each disease are discussed. To our knowledge, this is the firstreported case of endometrial cancer metastasis to the colon in theabsence of endometriosis. It demonstrates the importance of usingimmunohistochemistry to distinguish morphologically similar tumorsin a patient who seemingly presents with more than one primarymalignancy.

  19. Proteases of an Early Colonizer Can Hinder Streptococcus mutans Colonization in vitro

    OpenAIRE

    Wang, B.-Y.; Deutch, A.; Hong, J.; Kuramitsu, H K

    2011-01-01

    Streptococcus mutans is the primary cariogen that produces several virulence factors that are modulated by a competence-stimulating peptide (CSP) signaling system. In this study, we sought to determine if proteases produced by early dental plaque colonizers such as Streptococcus gordonii interfere with the subsequent colonization of S. mutans BM71 on the existing streptococcal biofilms. We demonstrated that S. mutans BM71 colonized much less efficiently in vitro on streptococcal biofilms than...

  20. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... Offices Close + - Text Size Get Tested for Colon Cancer [Video] This free video explains the most commonly ... Tools and Calculators Information for Health Care Professionals Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms ...

  1. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... explains the most commonly used screening methods, including test preparation, in simple language. View video Narrator : If ... cancer or even going for a colon cancer test can be frightening to you. “What if they ...

  2. Get Tested for Colon Cancer: Here's How

    Science.gov (United States)

    ... ACS » Your Local Offices Close + - Text Size Get Tested for Colon Cancer [Video] This free video explains ... 50 or older, make a decision and get tested. The only wrong choice is not getting tested. ...

  3. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... ACS » Your Local Offices Close + - Text Size Get Tested for Colon Cancer [Video] This free video explains ... 50 or older, make a decision and get tested. The only wrong choice is not getting tested. ...

  4. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... 800-227-2345 Home Learn About Cancer Stay Healthy Find Support & Treatment Explore Research Get Involved Find Local ACS Stay Healthy » Tools and Calculators » Videos » Get Tested for Colon ...

  5. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... to close share window. Print Share Save Saved this Article Close Push escape to close saved articles ... Text Size Get Tested for Colon Cancer [Video] This free video explains the most commonly used screening ...

  6. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... cat scan that yields three-dimensional images. Your physician can examine the lining of the bowel directly ... altered colon cell DNA, in your stools. Your doctor will give you one of a variety of ...

  7. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... Fecal occult blood test Fecal immunochemical test Stool DNA test Tests that prevent cancer: These tests examine ... of blood or cancerous material, altered colon cell DNA, in your stools. Your doctor will give you ...

  8. Colon Cancer Risk Assessment - Gauss Program

    Science.gov (United States)

    An executable file (in GAUSS) that projects absolute colon cancer risk (with confidence intervals) according to NCI’s Colorectal Cancer Risk Assessment Tool (CCRAT) algorithm. GAUSS is not needed to run the program.

  9. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... used screening methods, including test preparation, in simple language. View video Narrator : If you're like most people, the thought of getting colon cancer or even going for ...

  10. Treatment Options (by Stage) for Colon Cancer

    Science.gov (United States)

    ... for information about colorectal cancer in children. Health history can affect the risk of developing colon cancer. ... through. This procedure is called a colostomy. A bag is placed around the stoma to collect the ...

  11. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... each in detail. Tests that find cancer early: These tests detect tiny amounts of blood or cells ... test Stool DNA test Tests that prevent cancer: These tests examine the lining of the colon: the ...

  12. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... as you age. Fortunately you do have the power to keep colon cancer out of your life. ... the flexible instrument examinations or x-ray tests. Now the tests that can prevent cancer by finding ...

  13. Redefining Adjuvant Therapy for Colon Cancer

    Science.gov (United States)

    In this trial, patients with resected stage III colon cancer are being randomly assigned to receive FOLFOX chemotherapy for either 3 or 6 months and to take either a pill called celecoxib or a matching placebo pill for 3 years.

  14. Preventing Second Cancers in Colon Cancer Survivors

    Science.gov (United States)

    In this phase III trial, people who have had curative surgery for colon cancer will be randomly assigned to take sulindac and a placebo, eflornithine and a placebo, both sulindac and eflornithine, or two placebo pills for 36 months.

  15. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... articles window. My Saved Articles » My ACS » Your Local Offices Close + - Text Size Get Tested for Colon ... a Car About ACS About Us Contact Us Local Offices Volunteer Employment Become a Supplier Report Fraud ...

  16. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... as you age. Fortunately you do have the power to keep colon cancer out of your life. ... Blog Programs & Services Breast Cancer Support TLC Hair Loss & Mastectomy Products Hope Lodge® Lodging Rides To Treatment ...

  17. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... shall we say, not easy to talk about. Well, the good news is that colon cancer can ... Cancer Early ACS Programs to Help You Stay Well Tools and Calculators Information for Health Care Professionals ...

  18. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... life by finding cancer early. Each test has advantages and disadvantages. The challenge to you is to ... your colon with air then scans it. The advantages: the procedure takes only about 20 minutes, requires ...

  19. Understanding Antegrade Colonic Enema (ACE) Surgery

    Science.gov (United States)

    ... the bowel of feces. The procedure allows the emptying of the bowel by using fluid (similar to ... treatment of fecal incontinence in adults: use of gastric tube for catheterizable access to the descending colon. ...

  20. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... These tests detect tiny amounts of blood or cells that are shed by large polyps or early ... traces of blood or cancerous material, altered colon cell DNA, in your stools. Your doctor will give ...

  1. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... Close + - Text Size Get Tested for Colon Cancer [Video] This free video explains the most commonly used screening methods, including test preparation, in simple language. View video Narrator : If you're like most people, the ...

  2. Symptomatic colonic spirochaetosis in an immunocompetent patient

    OpenAIRE

    Lin, R K; Miyai, K; Carethers, J M

    2006-01-01

    Spirochaetes are organisms that can infect the colon of people with normal or compromised immune systems. Infected patients can present with a variety of gastrointestinal symptoms, including diarrhoea and rectal bleeding. However, some report a lack of association between specific symptoms and the presence of spirochaetes. It is therefore unclear whether the spirochaetes colonising the colon are true pathogens. Diagnosis is typically made by histological examination, with the biopsy specimen ...

  3. Colonization properties of Campylobacter jejuni in chickens

    OpenAIRE

    Pielsticker, C.; Glünder, G.; Rautenschlein, S.

    2012-01-01

    Campylobacter is the most common bacterial food-borne pathogen worldwide. Poultry and specifically chicken and raw chicken meat is the main source for human Campylobacter infection. Whilst being colonized by Campylobacter spp. chicken in contrast to human, do scarcely develop pathological lesions. The immune mechanisms controlling Campylobacter colonization and infection in chickens are still not clear. Previous studies and our investigations indicate that the ability to ...

  4. Lunar Colonization and NASA's Exploration Changes

    Science.gov (United States)

    Gavert, Raymond B.

    2006-01-01

    Space colonization is not part of NASA's mission planning. NASA's exploration vision, mission goals and program implementations, however, can have an important affect on private lunar programs leading towards colonization. NASA's exploration program has been described as a journey not a race. It is not like the Apollo mission having tight schedules and relatively unchanging direction. NASA of this era has competing demands from the areas of aeronautics, space science, earth science, space operations and, there are competing demands within the exploration program itself. Under the journey not a race conditions, an entrepreneur thinking about building a hotel on the Moon, with a road to an exploration site, might have difficulty determining where and when NASA might be at a particular place on the Moon. Lunar colonization advocates cannot depend on NASA or other nations with space programs to lead the way to colonization. They must set their own visions, mission goals and schedules. In implementing their colonization programs they will be resource limited. They would be like ``hitchhikers'' following the programs of spacefaring nations identifying programs that might have a fit with their vision and be ready to switch to other programs that may take them in the colonization direction. At times they will have to muster their own limited resources and do things themselves where necessary. The purpose of this paper is to examine current changes within NASA, as a lunar colonization advocate might do, in order to see where there might be areas for fitting into a lunar colonization strategy. The approach will help understand how the ``hitchhiking'' technique might be better utilized.

  5. Is a drain necessary after colonic anastomosis?

    OpenAIRE

    Johnson, C.D.; Lamont, P. M.; Orr, N; Lennox, M

    1989-01-01

    To date, there have been no clinical investigations of the usefulness of drains following colonic anastomosis in elective operations. We report a prospective study in which 49 patients were randomized to have a corrugated silastic drain (Portex) placed next to the colonic anastomosis. These patients were compared with a control group of 57 patients who had no drain. The two groups were similar in age, sex, diagnosis and site of anastomosis. There was no difference in outcome between the two g...

  6. Pneumocystis jirovecii colonization in chronic pulmonary disease

    OpenAIRE

    Gutiérrez S.; Respaldiza N.; Campano E.; Martínez-Risquez M.T.; Calderón E.J.; De La Horra C.

    2011-01-01

    Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P. jirovecii colonization has been found in patients with chronic pulmonary diseases it has been sugge...

  7. Oncolytic reovirus against ovarian and colon cancer.

    Science.gov (United States)

    Hirasawa, Kensuke; Nishikawa, Sandra G; Norman, Kara L; Alain, Tommy; Kossakowska, Anna; Lee, Patrick W K

    2002-03-15

    Reovirus selectively replicates in and destroys cancer cells with an activated Ras signaling pathway. In this study, we evaluated the feasibility of using reovirus (serotype 3, strain Dearing) as an antihuman colon and ovarian cancer agent. In in vitro studies, reovirus infection in human colon and ovarian cell lines was assessed by cytopathic effect as detected by light microscopy, [(35)S]Methionine labeling of infected cells for viral protein synthesis and progeny virus production by plaque assay. We observed that reovirus efficiently infected all five human colon cancer cell lines (Caco-2, DLD-1, HCT-116, HT-29, and SW48) and four human ovarian cancer cell lines (MDAH2774, PA-1, SKOV3, and SW626) which were tested, but not a normal colon cell line (CCD-18Co) or a normal ovarian cell line (NOV-31). We also observed that the Ras activity in the human colon and ovarian cancer cell lines was elevated compared with that in normal colon and ovarian cell lines. In animal models, intraneoplastic as well as i.v. inoculation of reovirus resulted in significant regression of established s.c. human colon and ovarian tumors implanted at the hind flank. Histological studies revealed that reovirus infection in vivo was restricted to tumor cells, whereas the surrounding normal tissue remained uninfected. Additionally, in an i.p. human ovarian cancer xenograft model, inhibition of ascites tumor formation and the survival of animals treated with live reovirus was significantly greater than of control mice treated with UV-inactivated reovirus. Reovirus infection in ex vivo primary human ovarian tumor surgical samples was also confirmed, further demonstrating the potential of reovirus therapy. These results suggest that reovirus holds promise as a novel agent for human colon and ovarian cancer therapy. PMID:11912142

  8. Triclosan Promotes Staphylococcus aureus Nasal Colonization

    OpenAIRE

    Syed, Adnan K.; Ghosh, Sudeshna; Love, Nancy G.; Boles, Blaise R.

    2014-01-01

    ABSTRACT The biocide triclosan is used in many personal care products, including toothpastes, soaps, clothing, and medical equipment. Consequently, it is present as a contaminant in the environment and has been detected in some human fluids, including serum, urine, and milk. Staphylococcus aureus is an opportunistic pathogen that colonizes the noses and throats of approximately 30% of the population. Colonization with S. aureus is known to be a risk factor for several types of infection. Here...

  9. Effects of morphine and naloxone on feline colonic transit

    International Nuclear Information System (INIS)

    The effects of endogenous and exogenous opioid substances on feline colonic transit were evaluated using colonic transit scintigraphy. Naloxone accelerated emptying of the cecum and ascending colon, and filling of the transverse colon. Endogenous opioid peptides thus appear to play a significant role in the regulation of colonic transit. At a moderate dose of morphine cecum and ascending colon transit was accelerated, while at a larger dose morphine had no effect. Since naloxone, a relatively nonspecific opioid antagonist, and morphine, a principally mu opioid receptor agonist, both accelerate proximal colonic transit, a decelerating role for at least one of the other opioid receptors is inferred

  10. Effects of morphine and naloxone on feline colonic transit

    Energy Technology Data Exchange (ETDEWEB)

    Krevsky, B.; Libster, B.; Maurer, A.H.; Chase, B.J.; Fisher, R.S.

    1989-01-01

    The effects of endogenous and exogenous opioid substances on feline colonic transit were evaluated using colonic transit scintigraphy. Naloxone accelerated emptying of the cecum and ascending colon, and filling of the transverse colon. Endogenous opioid peptides thus appear to play a significant role in the regulation of colonic transit. At a moderate dose of morphine cecum and ascending colon transit was accelerated, while at a larger dose morphine had no effect. Since naloxone, a relatively nonspecific opioid antagonist, and morphine, a principally mu opioid receptor agonist, both accelerate proximal colonic transit, a decelerating role for at least one of the other opioid receptors is inferred.

  11. PET-MRI in Diagnosing Patients With Colon or Rectal Cancer

    Science.gov (United States)

    2015-11-25

    Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IIA Colon Cancer; Stage IIA Rectal Cancer; Stage IIB Colon Cancer; Stage IIB Rectal Cancer; Stage IIC Colon Cancer; Stage IIC Rectal Cancer; Stage IIIA Colon Cancer; Stage IIIA Rectal Cancer; Stage IIIB Colon Cancer; Stage IIIB Rectal Cancer; Stage IIIC Colon Cancer; Stage IIIC Rectal Cancer; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer

  12. Ambivalent colonal relations in octavia butler’s wild seed

    Directory of Open Access Journals (Sweden)

    Thamer Amer Jubouri Al Ogaili

    2016-01-01

    Full Text Available This article explores postcolonial powers of ambivalence in Octavia Butler’s Wild Seed (1980. It will offer an in-depth analysis of the thematic and ideological characteristics of selected work. We will mainly focus on the theme of the mutual relationship between the colonized and the colonizer in the novel. This relationship is specified to the concept of ambivalence that incarnates the dual, yet, uncontrolled relationship between the colonized and the colonizer. Nevertheless, the colonized considers the colonizer as oppressive but an envious power; and the colonizer judges the colonized as inferior but indigenous. The colonial relationship will also be revealed by using the concept of self-other. Such concept scrutinizes the way the colonized and the colonizer perceive and resist each other. Thus, the study’s main focus point is the power relationship developed in the light of colonial ambivalence and self-other continuum. The colonial characteristics of this study offer a new interpretation of the colonial relationship depicted in the novel. Accordingly, the ambivalent relationship between the colonized and the colonizer will be equal (i.e. both of them have positive and negative attributes. This interpretation paves the way for other discourse studies interested in the depiction of the colonized and the colonizer relationship in postcolonial literature in general, and in Butler’s fiction in particular.

  13. Hemangioma colorretal Colon rectal hemangioma

    Directory of Open Access Journals (Sweden)

    João Batista Pinheiro Barreto

    2007-06-01

    Full Text Available O hemangioma colorretal (HCR é uma lesão vascular benigna rara, com manifestação clínica geralmente entre 5 e 25 anos de idade. Faz parte do diagnóstico diferencial das causas de hemorragia digestiva baixa, sendo confundido, na maioria das vezes, com entidades mais comuns, como hemorróidas e doenças inflamatórias intestinais. O retardo do diagnóstico ocorre freqüentemente devido ao desconhecimento da doença, com taxas de mortalidade alcançando 40 a 50% na presença de sangramento importante. O caso relatado é de uma paciente de 17 anos de idade, admitida no Serviço de Colo-proctologia do Hospital Universitário - HUUFMA, em setembro de 2005, com anemia e sangramento retal, desde a infância, de forma intermitente e não dolorosa. Apresentado sua história clínica e propedêutica diagnóstica, realizada por meio de exames laboratoriais, endoscopia digestiva alta, colonoscopia e arteriografia de mesentéricas e ilíacas internas. O tratamento cirúrgico realizado foi retossigmoidectomia convencional com anastomose colorretal baixa, com boa evolução pós-operatória, tendo o exame histopatológico da peça cirúrgica ressecada, confirmado o diagnostico.The colon and rectum hemangioma is a rare benign vascular lesion, with clinical features usually between 5 and 25 years of age. It is included in the differential diagnose of the lower digestive bleeding causes, and has been frequently misdiagnosed with other more common entities, like hemorrhoids and bowel inflammatory disease. The late diagnose occurs usually because of the rarity of the disease, with mortality rates reaching 40 to 50% in presence of severe bleeding. We report a case of a 17 years old girl who was admitted at the Coloproctology Service of the Academic Hospital - HUUFMA, in September 2005, with anemia and intermittent rectal bleeding since childhood. Laboratorial findings included laboratorial exams, GI endoscopy, colonoscopy and arteriography of mesenteric and

  14. Radiological findings in total colonic aganglionosis

    International Nuclear Information System (INIS)

    The radiological findings pathognomonic of Hirschsprung's disease have been known for quite a long time. However, in addition to those diseases characterized by rectum or rectum-sigmoid aganglionosis (as in the classic form of Hirschsprung's disease), in pediatric pathology of surgical interest severe affections exist characterized by aganglionosis extending from the rectum to the entire colon, and exceptionally as far as the small bowel (ultra-long Hirschsprung's disease). The authors report on the results they obtained in radiological studies of 6 cases of total colonic aganglionosis by means of the current radiological procedures, i.e. plain abdominal films and barium enema. As for total colonic aganglionosis, no diagnostic radiological parameters have been assessed yet. The authors compare their results with those taken from international literature: microcolon with reflux into megaileum (2 out of 6 cases) appears to be the most suggestive X-ray finding for total colonic aganglionosis. Finally, the role is discussed of radiological studies in the diagnostic approach to total colonic aganglionosis. The authors conclude that, even though radiological investigations are indispensable, they are often not conclusive. Therefore, an accurate evaluation of the proximal extension of aganglionosis can be made only at surgery

  15. Stromal tumor of colon: Case report

    Directory of Open Access Journals (Sweden)

    Nićiforović Dijana

    2008-01-01

    Full Text Available Introduction Gastrointestinal stromal tumor is relatively new term, it can be localized anywhere inside the gastrointestinal system. It has formerly been called leiomyoma, leiomyoblastoma, and/or leiomyosarcoma. Case report Case report is about a female patient with indefinite difficulties described as 'bother', mild anemia and anamnesis data of her mother who had been operated on for colon tumor. After blood examination, which had shown values within referential limits except for mild anemia, patient underwent radiological examination. Primarily, an abdominal cavity ultrasound had been performed, where a suspicious formation in the right hemiabdomen was found, but without distinctive anatomical localization in the abdominal cavity. Secondly, a checkup by Duplex Doppler ultrasound was made, as well as radiological examination with double contrast of colon and computed tomography, where tumor was visualized on ascendant colon with extraluminal localization. Discussion Radiological findings were confirmed by surgery. Histopathological findings were positive for gastrointestinal stromal colon tumor. Conclusion Gastrointestinal stromal tumors represent extremely rare tumors of gastrointestinal system, especially when localized at the colon, but they should be included in a differential diagnosis for their malignant potential.

  16. Nuclear microscopy of rat colon epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Ren, M., E-mail: phyrenmq@nus.edu.sg [Centre for Ion Beam Applications (CIBA), Department of Physics, National University of Singapore, Singapore 117542 (Singapore); Rajendran, Reshmi [Lab of Molecular Imaging, Singapore Bioimaging Consotium, 11 Biopolis Way, 02-02 Helios, Singapore 138667 (Singapore); Ng, Mary [Department of Pharmacology, National University of Singapore (Singapore); Udalagama, Chammika; Rodrigues, Anna E.; Watt, Frank [Centre for Ion Beam Applications (CIBA), Department of Physics, National University of Singapore, Singapore 117542 (Singapore); Jenner, Andrew Michael [Illawara Health and Medical Research Institute (IHMRI), University of Wollongong, NSW 2522 (Australia)

    2011-10-15

    Using Nuclear microscopy, we have investigated iron distributions in the colons of Sprague Dawley rats, in order to elucidate heme uptake. Four groups of five Sprague Dawley rats (mean weight 180 g) were fed different purified diets containing either heme diet (2.5% w/w hemoglobin), high fat diet (HFD) (18% w/w fat, 1% w/w cholesterol), 'western' diet (combination of hemoglobin 2.5% and 18% fat, 1% cholesterol) or control diet (7% w/w fat). After 4 weeks, animals were sacrificed by exsanguination after anaesthesia. Thin sections of frozen colon tissue were taken, freeze dried and scanned using nuclear microscopy utilising the techniques PIXE, RBS and STIM. The new data acquisition system (IonDaq) developed in CIBA was used to obtain high resolution images and line scans were used to map the iron distributions across the colon boundaries. The nuclear microscope results indicate that when HFD is given in addition to heme, the iron content of the epithelial cells that line the colon decreases, and the zinc in the smooth muscle wall increases. This implies that the level of heme and fat in diet has an important role in colon health, possibly by influencing epithelial cells directly or changing luminal composition such as bacterial flora or levels of metabolites and cytotoxins.

  17. PREOPERATIVE ENDOSCOPIC MARKING OF UNPALPABLE COLONIC TUMORS

    Directory of Open Access Journals (Sweden)

    A. L. Goncharov

    2015-02-01

    Full Text Available The identification of small colon lesions is one of the major problems in laparoscopic colonic resection.Research objective: to develop a technique of visualization of small tumors of a colon by preoperative endoscopic marking of a tumor.Materials and methods. In one day prior to operation to the patient after bowel preparation the colonoscopy is carried out. In the planned point near tumor on antimesentery edge the submucous infiltration of marking solution (Micky Sharpz blue tattoo pigment, UK is made. The volume of entered solution of 1–3 ml. In only 5 months of use of a technique preoperative marking to 14 patients with small (the size of 1–3 cm malignant tumors of the left colon is performed.Results. The tattoo mark was well visualized by during operation at 13 of 14 patients. In all cases we recorded no complications. Time of operation with preoperative marking averaged 108 min, that is significantly less in comparison with average time of operation with an intra-operative colonoscopy – 155 min (р < 0.001.Conclusions. The first experience of preoperative endoscopic marking of non palpable small tumors of a colon is encouraging. Performance of a technique wasn't accompanied by complications and allowed to reduce significantly time of operation and to simplify conditions of performance of operation.

  18. Space Colonization-Benefits for the World

    Science.gov (United States)

    Siegfried, W. H.

    2003-01-01

    We have begun to colonize space, even to the extent of early space tourism. Our early Vostok, Mercury, Gemini, Apollo, Skylab, Spacehab, Mir and now ISS are humankind's first ventures toward colonization. Efforts are underway to provide short space tours, and endeavors such as the X-Prize are encouraging entrepreneurs to provide new systems. Many believe that extended space travel (colonization) will do for the 21st century what aviation did for the 20th. Our current concerns including terrorism, hunger, disease, and problems of air quality, safe abundant water, poverty, and weather vagaries tend to overshadow long-term activities such as Space Colonization in the minds of many. Our leading ``think tanks'' such as the Woodrow Wilson International Center for Scholars and the Brookings Institute do not rate space travel high on lists of future beneficial undertakings even though many of the concerns listed above are prominently featured. It is the contention of this paper that Space Colonization will lead toward solutions to many of the emerging problems of our Earth, both technological and sociological. The breadth of the enterprise far exceeds the scope of our normal single-purpose missions and, therefore, its benefits will be greater.

  19. Nuclear microscopy of rat colon epithelial cells

    Science.gov (United States)

    Ren, M.; Rajendran, Reshmi; Ng, Mary; Udalagama, Chammika; Rodrigues, Anna E.; Watt, Frank; Jenner, Andrew Michael

    2011-10-01

    Using Nuclear microscopy, we have investigated iron distributions in the colons of Sprague Dawley rats, in order to elucidate heme uptake. Four groups of five Sprague Dawley rats (mean weight 180 g) were fed different purified diets containing either heme diet (2.5% w/w hemoglobin), high fat diet (HFD) (18% w/w fat, 1% w/w cholesterol), 'western' diet (combination of hemoglobin 2.5% and 18% fat, 1% cholesterol) or control diet (7% w/w fat). After 4 weeks, animals were sacrificed by exsanguination after anaesthesia. Thin sections of frozen colon tissue were taken, freeze dried and scanned using nuclear microscopy utilising the techniques PIXE, RBS and STIM. The new data acquisition system (IonDaq) developed in CIBA was used to obtain high resolution images and line scans were used to map the iron distributions across the colon boundaries. The nuclear microscope results indicate that when HFD is given in addition to heme, the iron content of the epithelial cells that line the colon decreases, and the zinc in the smooth muscle wall increases. This implies that the level of heme and fat in diet has an important role in colon health, possibly by influencing epithelial cells directly or changing luminal composition such as bacterial flora or levels of metabolites and cytotoxins.

  20. Mycelial colonization by bradyrhizobia and azorhizobia

    Indian Academy of Sciences (India)

    Gamini Seneviratne; H S Jayasinghearachchi

    2003-03-01

    This study examines mycelial colonization of common soil fungi by bradyrhizobia and an azorhizobial strain, resulting in the forming of biofilms. The effects of the fungal exudates on a bradyrhizobial strain have also been investigated. Bradyrhizobia gradually colonized the mycelia for about 18 days, after which the biofilm structures collapsed with the release of the rhizobial cell clusters to the culture medium. The azorhizobial strain showed differential colonization of the mycelia. In general, there were no considerable mycotoxin effects of the fungal exudates on the bradyrhizobial strain used, instead the rhizobial strain utilized the exudates as a source of nutrition. This study indicates that the present microbial association with biofilm formation has important implications in the survival of rhizobia under adverse soil conditions devoid of vegetation. Further, it could have developed an as yet unidentified nitrogen fixing system that could have contributed to the nitrogen economy of soils.

  1. Effect of ageing on colonic mucosal regeneration

    Institute of Scientific and Technical Information of China (English)

    Ferenc Sipos; Katalin Leiszter; Zsolt Tulassay

    2011-01-01

    The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the epithelium. On the one hand, age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation, which results in epithelial damage. On the other hand, the altered migration and function of regenerative stem cells, the age-related methylation of mucosal healing-associated genes, together with the alterations of growth factor signaling with age, may be involved in delayed mucosal regeneration. The connections of these alterations to the process of ageing are not fully known. The understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic strategies. Here, we aim to summarize the age-related microscopic and molecular changes of the human colon, as well as their role in altered mucosal healing.

  2. Pneumocystis jirovecii colonization in chronic pulmonary disease

    Directory of Open Access Journals (Sweden)

    Gutiérrez S.

    2011-05-01

    Full Text Available Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P. jirovecii colonization has been found in patients with chronic pulmonary diseases it has been suggested that P. jirovecii may play a role in the physiopathology and progression of those diseases. In this report we revise P. jirovecii colonization in different chronic pulmonary diseases such us, chronic obstructive pulmonary disease, interstitial lung diseases, cystic fibrosis and lung cancer.

  3. Extensive colonic stricture due to pelvic actinomycosis.

    Science.gov (United States)

    Kim, J C; Cho, M K; Yook, J W; Choe, G Y; Lee, I C

    1995-04-01

    A 36-year-old woman presented with a palpable tender mass at the left lower quadrant of the abdomen. She had suffered from constipation for five years and had a previous history of intrauterine device-use for one year. Preoperative barium enema and abdominopelvic CT showed a compatible finding of rectosigmoid colon cancer or left ovary cancer. She underwent segmental resection of the sigmoid colon along with the removal of left distal ureter, left ovary and salpinx. Pathologic examination revealed actinomycotic abscesses containing sulfur granules. Thereafter, she took parenteral ampicillin (50mg/kg/day) for one month and oral amoxicillin (250mg, tid) for 2 months consecutively. The patient has no specific problems for 6 months after surgical resection and long-term antibiotic therapy. This report may be the first of intrauterine device-associated pelvic actinomycosis involving both sigmoid colon and rectum extensively. PMID:7576294

  4. The colon. Clinical radiology and endoscopy

    International Nuclear Information System (INIS)

    This comprehensive reference work presents in-depth information on the diagnostic radiology and endoscopy of the colon. After a brief review of the history of colon examinations, two chapters explain the anatomy, physiology and pharmacology of the large intestine as well as the methods and techniques applied for radiological examination of the colon. The pathology and characteristical findings and the diagnostic evaluation of the various types of disease are the main subject, with the chapters discussing inflammations and tumors consuming by far most of the space, but there is also valuable information on vascular lesions, traumata, latrogenous or post-surgery lesions, among others, and on the characteristical findings in children. Numerous tables, radiographs and endoscopic images together with drawings illustrate and accompany the textbook information. (orig.). 492 figs., 95 tabs

  5. Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon-targeted matrix tablet.

    Science.gov (United States)

    Srivastava, Rishabh; Kumar, Deepesh; Pathak, Kamla

    2012-05-10

    The work was aimed at developing calcium-pectinate matrix tablet for colon-targeted delivery of meloxicam (MLX) microsponges. Modified quassi-emulsion solvent diffusion method was used to formulate microsponges (MS), based on 3(2) full factorial design. The effects of volume of dichloromethane and EudragitRS100 content (independent variables) were determined on the particle size, entrapment efficiency and %cumulative drug release of MS1-MS9. The optimized formulation, MS5 (d(mean)=44.47 μm, %EE=98.73, %CDR=97.32 and followed zero order release) was developed into colon-targeted matrix tablet using calcium pectinate as the matrix. The optimized colon-targeted tablet (MS5T2) shielded MLX loaded microsponges in gastrointestinal region and selectively delivered them to colon, as vizualized by vivo fluoroscopy in rabbits. The pharmacokinetic evaluation of MS5T2 in rabbits, revealed appearance of drug appeared in plasma after a lag time of 7h; a t(max) of 30 h with Fr=61.047%, thus presenting a formulation suitable for targeted colonic delivery. CLSM studies provided an evidence for colonic luminal retentive ability of microsponges at the end of 8h upon oral administration of MS5T2. Thus calcium pectinate matrix tablet loaded with MLX microsponges was developed as a promising system for the colon-specific delivery that has potential for use as an adjuvant therapy for colorectal cancer. PMID:22306039

  6. Fungal colonization of air-conditioning systems

    Directory of Open Access Journals (Sweden)

    Ljaljević-Grbić Milica

    2008-01-01

    Full Text Available Fungi have been implicated as quantitatively the most important bioaerosol component of indoor air associated with contaminated air-conditioning systems. rarely, indoor fungi may cause human infections, but more commonly allergenic responses ranging from pneumonitis to asthma-like symptoms. From all air conditioner filters analyzed, 16 fungal taxa were isolated and identified. Aspergillus fumigatus causes more lethal infections worldwide than any other mold. Air-conditioning filters that adsorb moisture and volatile organics appear to provide suitable substrates for fungal colonization. It is important to stress that fungal colonization of air-conditioning systems should not be ignored, especially in hospital environments.

  7. The Colonization of Space. An Anthropological Outlook

    Directory of Open Access Journals (Sweden)

    Moreno Tiziani

    2013-06-01

    Full Text Available The colonization of space implies an adaptation of both physical and cultural type. The human species is characterized by a great adaptive capacity that, in a basically extreme environment, reveals all its plasticity. However, this capacity must be aided by appropriate technological solutions that identify the problems related to long stays in space, and to long space voyages. Anthropology could aid future colonizers rethinking the environment of the spacecrafts, and the habitats of future colonies. Last but not least, anthropology can prepare them to a possible encounter with alien intelligences very different from human way of thinking.

  8. Our experience in congenital pouch colon

    Directory of Open Access Journals (Sweden)

    Gharpure Vivek

    2007-01-01

    Full Text Available Congenital pouch colon is considered to be a malformation seen only in north india. we carried out a prospective study of congenital pouch colon from 1991 to 2005 to determine what interventions are most suited for the short and long term management of this compex malformation. anatomical details, procedures and continence outcomes were recorded. patients were managed in a private and public hospital by a single surgeon. 17 patients could be enrolled in the study. we could reconstruct 16/17 patients. with aggressive bowel management, 9/14 patients could achieve continence.

  9. Prehistoric human colonization of India

    Indian Academy of Sciences (India)

    V N Misra

    2001-11-01

    Human colonization in India encompasses a span of at least half-a-million years and is divided into two broad periods, namely the prehistoric (before the emergence of writing) and the historic (after writing). The prehistoric period is divided into stone, bronze and iron ages. The stone age is further divided into palaeolithic, mesolithic and neolithic periods. As the name suggests, the technology in these periods was primarily based on stone. Economically, the palaeolithic and mesolithic periods represented a nomadic, hunting-gathering way of life, while the neolithic period represented a settled, food-producing way of life. Subsequently copper was introduced as a new material and this period was designated as the chalcolithic period. The invention of agriculture, which took place about 8000 years ago, brought about dramatic changes in the economy, technology and demography of human societies. Human habitat in the hunting-gathering stage was essentially on hilly, rocky and forested regions, which had ample wild plant and animal food resources. The introduction of agriculture saw it shifting to the alluvial plains which had fertile soil and perennial availability of water. Hills and forests, which had so far been areas of attraction, now turned into areas of isolation. Agriculture led to the emergence of villages and towns and brought with it the division of society into occupational groups. The first urbanization took place during the bronze age in the arid and semi-arid region of northwest India in the valleys of the Indus and the Saraswati rivers, the latter represented by the now dry Ghaggar–Hakra bed. This urbanization is known as the Indus or Harappan civilization which flourished during 3500–1500 B.C. The rest of India during this period was inhabited by neolithic and chalcolithic farmers and mesolithic hunter-gatherers. With the introduction of iron technology about 3000 years ago, the focus of development shifted eastward into the Indo-Gangetic divide

  10. Prehistoric human colonization of India.

    Science.gov (United States)

    Misra, V N

    2001-11-01

    Human colonization in India encompasses a span of at least half-a-million years and is divided into two broad periods, namely the prehistoric (before the emergence of writing) and the historic (after writing). The prehistoric period is divided into stone, bronze and iron ages. The stone age is further divided into palaeolithic, mesolithic and neolithic periods. As the name suggests, the technology in these periods was primarily based on stone. Economically, the palaeolithic and mesolithic periods represented a nomadic, hunting-gathering way of life, while the neolithic period represented a settled, food-producing way of life. Subsequently copper was introduced as a new material and this period was designated as the chalcolithic period. The invention of agriculture, which took place about 8000 years ago, brought about dramatic changes in the economy, technology and demography of human societies. Human habitat in the hunting-gathering stage was essentially on hilly, rocky and forested regions, which had ample wild plant and animal food resources. The introduction of agriculture saw it shifting to the alluvial plains which had fertile soil and perennial availability of water. Hills and forests, which had so far been areas of attraction, now turned into areas of isolation. Agriculture led to the emergence of villages and towns and brought with it the division of society into occupational groups. The first urbanization took place during the bronze age in the arid and semi-arid region of northwest India in the valleys of the Indus and the Saraswati rivers, the latter represented by the now dry Ghaggar-Hakra bed. This urbanization is known as the Indus or Harappan civilization which flourished during 3500-1500 B.C. The rest of India during this period was inhabited by neolithic and chalcolithic farmers and mesolithic hunter-gatherers. With the introduction of iron technology about 3000 years ago, the focus of development shifted eastward into the Indo-Gangetic divide and

  11. Postcolonial Times: Lock the Gate or Pull Down the Fences? A special Monograph Edition

    Directory of Open Access Journals (Sweden)

    Bill Boyd

    2013-06-01

    understands but that does not actually express what you mean, or speak your own language and risk the other party not understanding what you mean. Copyright © Bill Boyd 2013. This text may be archived and redistributed both in electronic form and in hard copy, provided that the author and journal are properly cited and no fee is charged. Coolabah, No.12, 2013, ISSN 1988-5946, Observatori: Centre d’Estudis Australians, Australian Studies Centre, Universitat de Barcelona 2 From a postcolonial studies perspective, this example reminds students of two key processes. First, students need to master the intellectual skills of the humanities in order to provide critical analysis of social situations. Secondly, students need to know that, as western scholars, they are as much part of any postcolonial problem as those in power, and therefore need to develop good reflective skills and to learn to think ‘otherwise’. This invited monograph is the text of the lecture, supplemented with further comments and illustrations, delivered to second year Humanities students at the University of Barcelona, Catalonia, on Monday 8th April 2013

  12. Cardiovascular and respiratory changes and convalescence in laparoscopic colonic surgery

    DEFF Research Database (Denmark)

    Schulze, S; Lyng, K M; Bugge, K; Perner, A; Bendtsen, A; Thorup, J; Nielsen, H J; Rasmussen, V; Rosenberg, J

    1999-01-01

    Gasless laparoscopy produces smaller cardiopulmonary and systemic changes than carbon dioxide (CO2) laparoscopy during colonic surgery.......Gasless laparoscopy produces smaller cardiopulmonary and systemic changes than carbon dioxide (CO2) laparoscopy during colonic surgery....

  13. Small Study Supports New Stool-Based Colon Cancer Test

    Science.gov (United States)

    ... 158388.html Small Study Supports New Stool-Based Colon Cancer Test Cologuard may help spot tumors, but researcher, ... more evidence that a recently approved, stool-based colon cancer test may be effective for certain patients. Still, ...

  14. What Women Need to Know about Colon Cancer Screening

    Science.gov (United States)

    ... you love): What Women Need to Know about Colon Cancer Screening March is National Colorectal Cancer Awareness Month ... the United States. Tests used for screening for colon cancer include digital rectal exam, stool blood test, barium ...

  15. Six Ways to Reduce Your Risk of Colon Cancer

    Science.gov (United States)

    ... html Six Ways to Reduce Your Risk of Colon Cancer Diet, weight and physical activity play a significant ... March 8, 2016 (HealthDay News) -- Half of the colon cancer cases in the United States could be prevented ...

  16. Statins Might Not Lower Colon Cancer Risk: Study

    Science.gov (United States)

    ... news/fullstory_158506.html Statins Might Not Lower Colon Cancer Risk: Study But cholesterol levels may be associated ... does not appear to reduce the risk of colon cancer, but a person's cholesterol levels might affect risk, ...

  17. A Little Excess Weight May Boost Colon Cancer Survival

    Science.gov (United States)

    ... 158930.html A Little Excess Weight May Boost Colon Cancer Survival Researchers saw an effect, but experts stress ... a surprise, a new study found that overweight colon cancer patients tended to have better survival than their ...

  18. Elderly with Advanced Colon Cancer Often Get Costly, Dubious Treatments

    Science.gov (United States)

    ... medlineplus/news/fullstory_157714.html Elderly With Advanced Colon Cancer Often Get Costly, Dubious Treatments: Study Drugs come ... far more often to elderly patients with advanced colon cancer, but they offer almost no benefit, a new ...

  19. Colonization of PAH-contaminated dredged sediment by earthworms

    NARCIS (Netherlands)

    Eijsackers, H.J.P.; Bruggeman, H.J.; Harmsen, J.; Kort, T.H.; Schakel, A.

    2009-01-01

    In freshly deposited dredged sediment contaminated with PAHs, we followed the colonization of earthworm species by monthly monitoring over two years. Already five months after deposition the first species, Lumbricus castaneus, appeared, although only temporarily. The first permanent colonizing speci

  20. Preterm Birth and Necrotizing Enterocolitis Alter Gut Colonization in Pigs

    DEFF Research Database (Denmark)

    Cilieborg, Malene S.; Boye, Mette; Mølbak, Lars;

    2011-01-01

    Necrotizing enterocolitis (NEC) in preterm neonates is dependent on bacterial colonization, but it remains unclear whether a particular microbiota or specific pathogens are involved. We hypothesized that gut colonization differs between preterm and term neonates and that overgrowth of Clostridium...

  1. The Genetics Revolution: Programs and Issues for the Community College. A Monograph Highlighting the Winners of the Exxon Education Foundation Innovation Awards.

    Science.gov (United States)

    Mays, Marilyn Elaine, Ed.

    Presented at a 1996 conference on the implications of the Human Genome Project for community and technical colleges, the 30 papers included in this monograph describe methods for incorporating genetics studies into the two-year college curriculum. Among the papers provided are: (1) "Facing the Unknown: The Ethical Challenges of Biotechnology" (J.…

  2. Using the Method of Paulo Freire in Nutrition Education: An Experimental Plan for Community Action in Northeast Brazil. Cornell International Nutrition Monograph Series, Number 3 (1975).

    Science.gov (United States)

    Drummon, Therese; Lotham, Michael C., Ed.

    This monograph provides an interpretation of the work and ideas of Paulo Freire and describes an attempt to use his methods in a preliminary trial of a small scale nutrition program in four villages in Maranhao State, Northeast Brazil. The introductory chapter indicates the seriousness of the nutritional problems of the rural poor as well as the…

  3. Designing Successful Transitions: A Guide for Orienting Students to College. 3rd Edition. The First-Year Experience Monograph Series No. 13

    Science.gov (United States)

    Ward-Roof, Jeanine A., Ed.

    2010-01-01

    The 2010 edition of this monograph addresses many topics (e.g., administration of orientation programs, family involvement, student characteristics and needs, assessment, and orientation for specific student populations and institutional types) that were included in previous editions but approaches them with new information, updated data, and…

  4. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    NARCIS (Netherlands)

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species delimitat

  5. The Decline in Breastfeeding: An Analysis of the Role of the Nestle Corporation from Two Perspectives. Cornell International Nutrition Monograph Series, Number 11 (1982).

    Science.gov (United States)

    Campbell, Carolyn E.

    An attempt is made to analyze the ascendancy of formula feeding of infants in terms of the conflicting ideologies of Marxism and capitalism. The decline of breastfeeding is traced, and is linked with the interrelated phenomena of free market economics and the domination of women by men in Western society. The monograph has two sections:…

  6. Red meat and colon cancer: a possible role for heme

    OpenAIRE

    Sesink, Aloysius Lambertus Antonia

    2000-01-01

    Sporadic colon cancer is a multifactorial aging disease affected by long-term exposure to environmental risk factors. Epidemiological studies have shown that risk for colon cancer is associated with diets high in red meat and/or animal fat. The mechanisms by which colonic tumors arise are, however, poorly understood (see General Introduction, chapter 1). The general hypothesis purports that animal saturated fat increases soluble secondary bile acids and fatty acids in the colonic lumen. These...

  7. Chemopreventive effect of apple and berry fruits against colon cancer

    OpenAIRE

    Jaganathan, Saravana Kumar; Vellayappan, Muthu Vignesh; Narasimhan, Gayathri; Supriyanto, Eko; Octorina Dewi, Dyah Ekashanti; Narayanan, Aqilah Leela T; Balaji, Arunpandian; Subramanian, Aruna Priyadarshini; Yusof, Mustafa

    2014-01-01

    Colon cancer arises due to the conversion of precancerous polyps (benign) found in the inner lining of the colon. Prevention is better than cure, and this is very true with respect to colon cancer. Various epidemiologic studies have linked colorectal cancer with food intake. Apple and berry juices are widely consumed among various ethnicities because of their nutritious values. In this review article, chemopreventive effects of these fruit juices against colon cancer are discussed. Studies de...

  8. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

    OpenAIRE

    Chao, Yashuan; Marks, Laura R.; Pettigrew, Melinda M.; Hakansson, Anders P.

    2015-01-01

    Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization results in millions of infections and over one million deaths per year, mostly in individuals under the age of 5 and the elderly. Colonizing pneumococci form well-organized biofilm communities in the nasopharyngeal environment, but the specific role of biofilms and their interaction with the host during colonization and disease...

  9. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

    OpenAIRE

    Yashuan eChao; Marks, Laura R.; Pettigrew, Melinda M.; Hakansson, Anders P.

    2015-01-01

    Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization results in millions of infections and over 1 million deaths per year, mostly in individuals under the age of 5 and the elderly. Colonizing pneumococci form well-organized biofilm communities in the nasopharyngeal environment, but the specific role of biofilms and their interaction with the host during colonization and disease i...

  10. POLYSACCHARIDE MATRIX TABLET FOR COLON SPECIFIC DRUG DELIVERY

    OpenAIRE

    Amit Kumar Panigrahi et al

    2012-01-01

    The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting characteristics. The colon targeting properties were evaluated by analysing the formulations for drug rele...

  11. Colonic Fermentation Promotes Decompression sickness in Rats.

    Science.gov (United States)

    de Maistre, Sébastien; Vallée, Nicolas; Gempp, Emmanuel; Lambrechts, Kate; Louge, Pierre; Duchamp, Claude; Blatteau, Jean-Eric

    2016-01-01

    Massive bubble formation after diving can lead to decompression sickness (DCS). During dives with hydrogen as a diluent for oxygen, decreasing the body's H2 burden by inoculating hydrogen-metabolizing microbes into the gut reduces the risk of DCS. So we set out to investigate if colonic fermentation leading to endogenous hydrogen production promotes DCS in fasting rats. Four hours before an experimental dive, 93 fasting rats were force-fed, half of them with mannitol and the other half with water. Exhaled hydrogen was measured before and after force-feeding. Following the hyperbaric exposure, we looked for signs of DCS. A higher incidence of DCS was found in rats force-fed with mannitol than in those force-fed with water (80%, [95%CI 56, 94] versus 40%, [95%CI 19, 64], p < 0.01). In rats force-fed with mannitol, metronidazole pretreatment reduced the incidence of DCS (33%, [95%CI 15, 57], p = 0.005) at the same time as it inhibited colonic fermentation (14 ± 35 ppm versus 118 ± 90 ppm, p = 0.0001). Pre-diveingestion of mannitol increased the incidence of DCS in fasting rats when colonic fermentation peaked during the decompression phase. More generally, colonic fermentation in rats on a normal diet could promote DCS through endogenous hydrogen production. PMID:26853722

  12. A Higher-Order Colon Translation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse Reichstein

    2001-01-01

    A lambda-encoding such as the CPS transformation gives rise to administrative redexes. In his seminal article ``Call-by-name, call-by-value and the lambda-calculus'', 25 years ago, Plotkin tackled administrative reductions using a so-called ``colon translation.'' 10 years ago, Danvy and Filinski...

  13. A Higher-Order Colon Translation

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse R.

    2000-01-01

    A lambda-encoding such as the CPS transformation gives rise to administrative redexes. In his seminal article ``Call-by-name, call-by-value and the lambda-calculus'', 25 years ago, Plotkin tackled administrative reductions using a so-called ``colon translation.'' 10 years ago, Danvy and Filinski...

  14. Noninvasive measurement of human ascending colon volume

    International Nuclear Information System (INIS)

    The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tcm-labelled Amberlite pellets. Two- and 3-D images were obtained using a gamma camera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate. Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT. (Author)

  15. Bacteria interfere with A-actinomycetemcomitans colonization

    OpenAIRE

    Teughels, Wim; Haake, S. Kinder; Sliepen, Isabelle; Pauwels, Martine; Van Eldere, Johan; Cassiman, Jean-Jacques; Quirynen, Marc

    2007-01-01

    It is known that beneficial bacteria can suppress the emergence of pathogenic bacteria, particularly in the gastrointestinal tract. This study examined the potential for a similar suppression of Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans colonization of epithelial cells, due to its potential relevance in periodontal diseases. Seven presumed beneficial bacteria were examined for their ability to interfere, exclude, or displace A. actinomycetemcomitans from epithelial cells...

  16. Metabolic Syndrome X and Colon Cancer

    Czech Academy of Sciences Publication Activity Database

    Matoulek, M.; Svobodová, S.; Svačina, Š.; Plavcová, Marie; Zvárová, Jana; Visokai, V.; Lipská, M.

    2003-01-01

    Roč. 27, suppl. 1 (2003), s. 86. ISSN 0307-0565. [European Congress on Obesity /12./. 29.05.2003-01.06.2003, Helsinki] R&D Projects: GA MZd NB6635; GA MŠk LN00B107 Keywords : metabolic syndrome X * colon cancer Subject RIV: BB - Applied Statistics, Operational Research

  17. Radiologic analysis of total colonic aganglionosis

    International Nuclear Information System (INIS)

    Radiologic findings of Total Colonic Aganglionosis (T.C.A) were analyzed in 15 patients with the results as follows; 1. Male to female ratio was 8:7. 2. There were six cases of small calibered colon, seven cases of normal colon and two cases of megacolon. 3. Free reflux of barium into the small bowel was observed in seven cases out of eight in which retrograde filling was tried. 4. Delayed films (24 hrs or more) were available in eight cases and most of the barium remained in bowel in six cases. 5. There were abnormal colonic contractions in three cases, decreased redundancy in five and five cases or irregular, hypertrophic mucosal wall suggesting enterocolitis. 6. Part of ileum were also aganglionic in five cases. There seems to be no pathognomonic barium enema findings in T.C.A But combination of these findings may suggest the possibility of T.C.A. T.C.A should be considered in differential diagnosis of bowel obstruction in infants. Barium enema should be complete and delayed films always be obtained

  18. Wnt signaling and colon carcinogenesis: Beyond APC

    Directory of Open Access Journals (Sweden)

    Rani Najdi

    2011-01-01

    Full Text Available Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene (APC is a critical event in the development of colon cancer. For colon carcinogenesis, however, constitutive signaling through the canonical Wnt pathway is not a singular event. Here we review how canonical Wnt signaling is modulated by intracellular LEF/TCF composition and location, the action of different Wnt ligands, and the secretion of Wnt inhibitory molecules. We also review the contributions of non-canonical Wnt signaling and other distinct pathways in the tumor micro environment that cross-talk to the canonical Wnt pathway and thereby influence colon cancer progression. These ′non-APC′ aspects of Wnt signaling are considered in relation to the development of potential agents for the treatment of patients with colon cancer. Regulatory pathways that influence Wnt signaling highlight how it might be possible to design therapies that target a network of signals beyond that of APC and β-catenin.

  19. Lucy and the Mark of the Colonizer

    Institute of Scientific and Technical Information of China (English)

    闫枫

    2014-01-01

    The novel is a an initiation novel of Lucy.Through this novel Lucy grows from a girl resenting and fighting against the everything that tries to colonize her into an independent girl who begins to accept and understand the people and world around her. Colonial themes of identity confusion stand out in this novel.

  20. Colonic perianastomotic carcinogenesis in an experimental model

    International Nuclear Information System (INIS)

    To examine the effect of anastomosis on experimental carcinogenesis in the colon of rats. Forty-three 10-week-old male and female Sprague-Dawley rats were operated on by performing an end-to-side ileorectostomy. Group A:16 rats received no treatment. Group B: 27 rats received 18 subcutaneous injections weekly at a dose of 21 mg/kg wt of 1–2 dimethylhydrazine (DMH), from the eighth day after the intervention. Animals were sacrificed between 25–27 weeks. The number of tumours, their localization, size and microscopic characteristics were recorded. A paired chi-squared analysis was performed comparing tumoral induction in the perianastomotic zone with the rest of colon with faeces. No tumours appeared in the dimethylhydrazine-free group. The percentage tumoral area was greater in the perianastomotic zone compared to tumours which had developed in the rest of colon with faeces (p = 0.014). We found a cocarcinogenic effect due to the creation of an anastomosis, when using an experimental model of colonic carcinogenesis induced by DMH in rats

  1. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... shall we say, not easy to talk about. Well, the good news is that colon cancer can often be prevented or it can be found and removed ... Away from Tobacco Eat Healthy and Get Active Be Safe in the Sun Other Ways to Protect ... and Calculators Information for Health Care Professionals ...

  2. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... filling the colon with air or with an x-ray blocking liquid and taking a special x-ray or performing a CT or cat scan that ... able to undergo the flexible instrument examinations or x-ray tests. Now the tests that can prevent cancer ...

  3. Prostate, Lung, Colon, and Ovary Prospective Study

    Science.gov (United States)

    A large cohort study of etiologic determinants of cancer carried out within an NCI trial for the evaluation of screening procedures for the early detection of prostate, lung, colon, and ovarian cancer (the PLCO Trial) at 10 U.S. screening centers

  4. Melanocyte colonization and pigmentation of breast carcinoma

    DEFF Research Database (Denmark)

    Mele, Marco; Laurberg, Tinne; Engberg Damsgaard, Tine;

    2012-01-01

    Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The...

  5. Stercoral Perforation of the Colon in Pregnancy

    OpenAIRE

    Atkinson AL; Pepe A

    2010-01-01

    We report a 37 year old multi-parous lady, who in her third trimester of pregnancy, presented to the emergency room with acute diffuse abdominal pain and involuntary guarding. Findings on physical examination were consistent with peritonitis and a decision was made by the admitting team to perform an urgent laparotomy which surprisingly showed a stercoral perforation of the colon.

  6. Postoperative omental infarction following colonic resection

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, S.F., E-mail: skerr44@doctors.org.uk [Department of Radiology, Leeds General Infirmary, Leeds (United Kingdom); Hyland, R.; Rowbotham, E.; Chalmers, A.G. [Department of Radiology, Leeds General Infirmary, Leeds (United Kingdom)

    2012-02-15

    Aim: To illustrate the computed tomography (CT) appearances and natural history of postoperative omental infarction following colonic resection and to highlight the important clinical implications of this radiological diagnosis. Materials and methods: Over a 3 year period, 15 patients with a history of colonic resection were identified as having a CT diagnosis of postoperative omental infarction. Relevant clinical and pathological data were retrospectively collected from the institution's electronic patient records system and all relevant imaging was reviewed, including serial CT images in 10 patients. Results: A diagnosis of postoperative omental infarction was made in symptomatic and asymptomatic patients who had undergone open or laparoscopic colonic resection for benign or malignant disease. CT appearances ranged from diffuse omental stranding to discrete masses, which typically appeared within weeks of surgery and could persist for years. In four (36%) of the patients with colorectal cancer, the CT appearances raised concern for recurrent malignancy, but percutaneous biopsy and/or serial CT allowed a confident diagnosis of omental infarction to be made. Although most cases were self-limiting, three (20%) cases were complicated by secondary infection and required radiological or surgical intervention. Conclusion: Postoperative omental infarction is an under-recognized complication of colonic resection. It has the potential to mimic recurrent malignancy and may require radiological or surgical intervention for secondary infection.

  7. Postoperative omental infarction following colonic resection

    International Nuclear Information System (INIS)

    Aim: To illustrate the computed tomography (CT) appearances and natural history of postoperative omental infarction following colonic resection and to highlight the important clinical implications of this radiological diagnosis. Materials and methods: Over a 3 year period, 15 patients with a history of colonic resection were identified as having a CT diagnosis of postoperative omental infarction. Relevant clinical and pathological data were retrospectively collected from the institution’s electronic patient records system and all relevant imaging was reviewed, including serial CT images in 10 patients. Results: A diagnosis of postoperative omental infarction was made in symptomatic and asymptomatic patients who had undergone open or laparoscopic colonic resection for benign or malignant disease. CT appearances ranged from diffuse omental stranding to discrete masses, which typically appeared within weeks of surgery and could persist for years. In four (36%) of the patients with colorectal cancer, the CT appearances raised concern for recurrent malignancy, but percutaneous biopsy and/or serial CT allowed a confident diagnosis of omental infarction to be made. Although most cases were self-limiting, three (20%) cases were complicated by secondary infection and required radiological or surgical intervention. Conclusion: Postoperative omental infarction is an under-recognized complication of colonic resection. It has the potential to mimic recurrent malignancy and may require radiological or surgical intervention for secondary infection.

  8. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... that colon cancer can often be prevented or it can be found and removed before it has a chance to become a danger to ... common cancers. Both women and men can have it. And the chances of having it increase as ...

  9. Radiologic analysis of total colonic aganglionosis

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Duk; Yeon, Kyung Mo [College of Medicine, Seoul National University, Seoul (Korea, Republic of)

    1985-08-15

    Radiologic findings of Total Colonic Aganglionosis (T.C.A) were analyzed in 15 patients with the results as follows; 1. Male to female ratio was 8:7. 2. There were six cases of small calibered colon, seven cases of normal colon and two cases of megacolon. 3. Free reflux of barium into the small bowel was observed in seven cases out of eight in which retrograde filling was tried. 4. Delayed films (24 hrs or more) were available in eight cases and most of the barium remained in bowel in six cases. 5. There were abnormal colonic contractions in three cases, decreased redundancy in five and five cases or irregular, hypertrophic mucosal wall suggesting enterocolitis. 6. Part of ileum were also aganglionic in five cases. There seems to be no pathognomonic barium enema findings in T.C.A But combination of these findings may suggest the possibility of T.C.A. T.C.A should be considered in differential diagnosis of bowel obstruction in infants. Barium enema should be complete and delayed films always be obtained.

  10. [Brazilian colonization in the Paraguayan agricultural frontier].

    Science.gov (United States)

    Neupert, R F

    1991-04-01

    This work briefly describes Brazilian colonization of the Paraguayan agricultural frontier, analyzes factors responsible for expelling population from Brazil and for attracting Brazilians to Paraguay, and assesses the economic and social consequences of immigration to the area. Paraguay's vast and sparsely populated agricultural frontier in areas outside the Central subregion underwent a process of intense colonization from the early 1960s to the mid-1980s. The Paraguayan government initiated an ambitious colonization program in 1963 to increase production, relieve population pressure and subdivision of small parcels in the Central subregion, encourage agricultural modernization, and produce a more diversified agriculture. Paraguayan agriculture in the early 1960s suffered from excessive concentration of land in a few hands and resulting exclusion of around 3/4 of workers from ownership and from any possibility of obtaining credit to fund technological improvements. Results of studies 2 decades after implementation of the colonization plan suggest that it has failed in significant areas. Although a considerable population redistribution alleviated pressure in the Central subregion, it apparently resulted more from spontaneous movement of peasants outside the colonization areas than from the official program. Concentration of lands is now occurring in the colonization area. Assistance for agricultural modernization and diversification of production in the peasant sector has been minimal. On the other hand, production of soy, wheat, and cotton for export increased substantially, because of an entrepreneurial agriculture capitalized by foreign as well as national interests The unmet goals of the colonization program would have required structural reforms rather than simple spatial redistribution of the population. Many of the colonists in the 1970s were Brazilian families displaced by mechanized agriculture in the southern states of Parana, Santa Catarina, and Rio

  11. 21 CFR 876.5220 - Colonic irrigation system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Colonic irrigation system. 876.5220 Section 876...) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Therapeutic Devices § 876.5220 Colonic irrigation system. (a) Identification. A colonic irrigation system is a device intended to instill water into the...

  12. Segmental dilatation of colon associated with anorectal malformation

    Directory of Open Access Journals (Sweden)

    Mahajan J

    2007-01-01

    Full Text Available Children with segmental dilatation of the colon suffer severe constipation and are clinically indistinguishable from Hirschsprung disease. Segmental dilatation of colon is rare in neonates. In this report, a neonate with unusual combination of segmental dilatation of the colon and high anorectal malformation is presented.

  13. Schwannoma—A Rare Subepithelial Lesion of the Colon

    OpenAIRE

    Sandra Barbeiro; Catarina Martins; Cláudia Gonçalves; Bruno Arroja; Manuela Canhoto; Filipe Silva; Isabel Cotrim; Cristina Amado; Liliana Eliseu; Helena Vasconcelos

    2015-01-01

    Schwannoma is a benign tumor arising from Schwann cells that form the neural sheath. Primary schwannoma of the colon is rare and a few cases have been reported. We report a case of schwannoma of the colon and present the differential diagnosis that must be considered in the evaluation of colonic subepithelial lesions.

  14. Isolation and in vitro expansion of human colonic stem cells

    NARCIS (Netherlands)

    Jung, P.; Sato, T.; Merlos-Suarez, A.; Barriga, F.M.; Iglesias, M.; Rossell, D.; Auer, H.; Gallardo, M.; Blasco, M.A.; Sancho, E.; Clevers, H.; Batlle, E.

    2011-01-01

    Here we describe the isolation of stem cells of the human colonic epithelium. Differential cell surface abundance of ephrin type-B receptor 2 (EPHB2) allows the purification of different cell types from human colon mucosa biopsies. The highest EPHB2 surface levels correspond to epithelial colonic ce

  15. Neonatal small left colon in an infant with cystic fibrosis

    International Nuclear Information System (INIS)

    A small left colon has been observed in neonates due to several causes: aganglionosis, meconium plug, and neonatal small left colon syndrome. We report a case of small left colon in an infant with cystic fibrosis, underscoring the need to consider this diesease in the diagnostic work up. (orig.)

  16. Transverse colon tuberculosis. A case presentation and clinical review

    International Nuclear Information System (INIS)

    We describe the clinical case of a 90 year old female patient presenting weight loss and anemia. The physical examination detected an abdominal mass in epigastrio. Abdominal scanner revealed wall thickness at transverse colon. A colonoscopy was performed, finding an infiltrating mass at this level. The biopsies informed colonic tuberculosis. We present a literature review of digestive TBC, emphasising in colonic tuberculosis.

  17. Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers

    DEFF Research Database (Denmark)

    Halvarsson, Britta; Anderson, Harald; Domanska, Katarina; Lindmark, Gudrun; Nilbert, Mef

    2008-01-01

    Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers...... and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. Udgivelsesdato: 2008-Feb...

  18. The role of colonic metabolism in lactose intolerance

    NARCIS (Netherlands)

    He, T.; Venema, K.; Priebe, M.G.; Welling, G.W.; Brummer, R.J.M.; Vonk, R.J.

    2008-01-01

    Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fer

  19. Entamoeba histolytica-Secreted Products Degrade Colonic Mucin Oligosaccharides

    OpenAIRE

    Moncada, Darcy; Keller, Kathy; Chadee, Kris

    2005-01-01

    Degradation of the mucus layer by Entamoeba histolytica is a prerequisite for invasion of the colonic mucosa. In this study, we demonstrate that amoeba-secreted products degrade 3H-labeled and native colonic mucin oligosaccharides independently of proteolytic activity. We conclude that E. histolytica degrades mucin oligosaccharides, which may facilitate parasite invasion of the colon.

  20. Dynamic occupancy models for explicit colonization processes

    Science.gov (United States)

    Broms, Kristin M.; Hooten, Mevin B.; Johnson, Devin S.; Altwegg, Res; Conquest, Loveday

    2016-01-01

    The dynamic, multi-season occupancy model framework has become a popular tool for modeling open populations with occupancies that change over time through local colonizations and extinctions. However, few versions of the model relate these probabilities to the occupancies of neighboring sites or patches. We present a modeling framework that incorporates this information and is capable of describing a wide variety of spatiotemporal colonization and extinction processes. A key feature of the model is that it is based on a simple set of small-scale rules describing how the process evolves. The result is a dynamic process that can account for complicated large-scale features. In our model, a site is more likely to be colonized if more of its neighbors were previously occupied and if it provides more appealing environmental characteristics than its neighboring sites. Additionally, a site without occupied neighbors may also become colonized through the inclusion of a long-distance dispersal process. Although similar model specifications have been developed for epidemiological applications, ours formally accounts for detectability using the well-known occupancy modeling framework. After demonstrating the viability and potential of this new form of dynamic occupancy model in a simulation study, we use it to obtain inference for the ongoing Common Myna (Acridotheres tristis) invasion in South Africa. Our results suggest that the Common Myna continues to enlarge its distribution and its spread via short distance movement, rather than long-distance dispersal. Overall, this new modeling framework provides a powerful tool for managers examining the drivers of colonization including short- vs. long-distance dispersal, habitat quality, and distance from source populations.

  1. Second Colonization%第二殖民

    Institute of Scientific and Technical Information of China (English)

    李士桥; 张天洁

    2012-01-01

    殖民虽然来自统治,但殖民的效果是双向的.当今的研究往往关注于权力流向源头的文化特征和殖民活动,而将反向的活动看做补充资料.提出第二殖民的观念,希望将反于权力流向的“殖民”活动以同等的框架来对待.这里,在抛开权力流向的基础上,一个文化对另一个文化同样施展了暴力,做出了修改.在这个前提下,可以将第二殖民分为主动的和被动的,模仿型的和变革型的.希望通过这些直接的描述,对文化交汇的研究,可以触及其一系列仍然比较模糊的研究内容和方向.%Colonization results from domination, but the effect of colonization is bilateral. In current scholarship in the activities of colonization, there seems to be a framework that assumes the primary position of the cultural features of the source of the flow of power, taking the activities in the reverse direction as supplementary materials. Second colonization suggests that these activities in the reverse direction should be studied in equal intensity; here, as we cast aside the direction of power, one culture commits violence to and revises influences from another culture equally. Under this assumption, we can understand second colonization as being internal and external, mimetic and figurative; through these direct descriptions, the paper hope to suggest ways to investigate directions and areas of research which are still indistinct.

  2. Methicillin-Resistant Staphylococcus aureus Colonization in Schoolteachers in Ontario

    Directory of Open Access Journals (Sweden)

    Beth A Hanselman

    2008-01-01

    Full Text Available A prospective study of methicillin-resistant Staphylococcus aureus (MRSA colonization was performed involving teachers at a science teachers’ conference in Toronto, Ontario. Nasal swabs and questionnaire data were collected from consenting individuals. MRSA colonization was identified in seven of 220 (3.2% participants. No colonized individuals reported recent contact with the health care system, antimicrobial therapy, residence with health care workers or previous MRSA infections. Methicillin-susceptible S aureus colonization was identified in 72 of 220 (33% individuals. The prevalence of MRSA colonization was higher than expected for a purportedly low-risk population.

  3. Methicillin-resistant Staphylococcus aureus colonization in schoolteachers in Ontario.

    Science.gov (United States)

    Hanselman, Beth A; Kruth, Steven A; Rousseau, Joyce; Weese, J Scott

    2008-11-01

    A prospective study of methicillin-resistant Staphylococcus aureus (MRSA) colonization was performed involving teachers at a science teachers' conference in Toronto, Ontario. Nasal swabs and questionnaire data were collected from consenting individuals. MRSA colonization was identified in seven of 220 (3.2%) participants. No colonized individuals reported recent contact with the health care system, antimicrobial therapy, residence with health care workers or previous MRSA infections. Methicillin-susceptible S aureus colonization was identified in 72 of 220 (33%) individuals. The prevalence of MRSA colonization was higher than expected for a purportedly low-risk population. PMID:19436569

  4. Mechanisms and rates of bacterial colonization of sinking aggregates

    DEFF Research Database (Denmark)

    Kiørboe, Thomas; Grossart, H.P.; Ploug, H.;

    2002-01-01

    Quantifying the rate at which bacteria colonize aggregates is a key to understanding microbial turnover of aggregates. We used encounter models based on random walk and advection-diffusion considerations to predict colonization rates from the bacteria's motility patterns (swimming speed, tumbling...... (0 to 2 s(-1)). The rates at which these bacteria colonized artificial aggregates (stationary and sinking) largely agreed with model predictions. We report several findings. (i) Motile bacteria rapidly colonize aggregates, whereas nonmotile bacteria do not. 00 Flow enhances colonization rates. (iii...

  5. Neoadjuvant chemotherapy in locally advanced colon cancer

    DEFF Research Database (Denmark)

    Jakobsen, Anders; Andersen, Fahimeh; Fischer, Anders;

    2015-01-01

    BACKGROUND: Neoadjuvant chemotherapy has proven valuable in several tumors, but it has not been elucidated in colon cancer. The present phase II trial addressed the issue in high-risk patients selected by computed tomography (CT) scan. MATERIAL AND METHODS: Patients with resectable colon cancer...... mutational status received three cycles of capecitabine 2000 mg/m(2) days 1-14 q3w and oxaliplatin 130 mg iv day 1 q3w. Wild-type patients received the same chemotherapy supplemented with panitumumab 9 mg/kg iv q3w. After the operation, patients fulfilling the international criteria for adjuvant chemotherapy......, i.e. high-risk stage II and III patients, received five cycles of the same chemotherapy without panitumumab. Patients not fulfilling the criteria were offered follow-up only. The primary endpoint was the fraction of patients not fulfilling the criteria for adjuvant chemotherapy (converted patients...

  6. Terahertz polarization imaging for colon cancer detection

    Science.gov (United States)

    Doradla, Pallavi; Alavi, Karim; Joseph, Cecil S.; Giles, Robert H.

    2014-03-01

    Continuous wave terahertz (THz) imaging has the potential to offer a safe, noninvasive medical imaging modality for delineating colorectal cancer. The terahertz reflectance measurements of fresh 3 - 5 mm thick human colonic excisions were acquired using a continuous-wave polarization imaging technique. A CO2 optically pumped Far- Infrared molecular gas laser operating at 584 GHz was used to illuminate the colon tissue, while the reflected signals were detected using a liquid Helium cooled silicon bolometer. Both co-polarized and cross-polarized remittance from the samples was collected using wire grid polarizers in the experiment. The experimental analysis of 2D images obtained from THz reflection polarization imaging techniques showed intrinsic contrast between cancerous and normal regions based on increased reflection from the tumor. Also, the study demonstrates that the cross-polarized terahertz images not only correlates better with the histology, but also provide consistent relative reflectance difference values between normal and cancerous regions for all the measured specimens.

  7. Colon cancer stem cells: implications in carcinogenesis

    OpenAIRE

    Sanders, Matthew A.; Majumdar, Adhip P. N.

    2011-01-01

    The cancer stem cell model was described for hematologic malignancies in 1997 and since then evidence has emerged to support it for many solid tumors as well, including colon cancer. This model proposes that certain cells within the tumor mass are pluripotent and capable of self-renewal and have an enhanced ability to initiate distant metastasis. The cancer stem cell model has important implications for cancer treatment, since most current therapies target actively proliferating cells and may...

  8. Congenital pouch colon in female subjects

    Directory of Open Access Journals (Sweden)

    Sarin Y

    2007-01-01

    Full Text Available Over a period of 5-year (May 2000 to April 2005 29 patients of congenital pouch colon (CPC were managed by single pediatric surgeon in the Department of Pediatric Surgery of a tertiary hospital. Of these, 11 were girls (M: F: 1.6:1. Detailed anatomy could be studied in nine patients, were included in this study. Age of presentation in female subjects ranged 1 day to 8 years. On examination, eight of the nine patients had single perineal opening suggesting a very high incidence of association of cloaca in female subjects with CPC. Four had short urogenital sinus with colonic pouch opening in the posterior wall of urinary bladder. In other two patients, CPC terminated in short cloaca. Anomalies of mullerian structures such as uterus didelphus and septate vagina ware commonly encountered. Proximal diversion with or without pouch excision was done as the initial preliminary treatment for all those patients who presented in early life. Of the nine girls, two died after the preliminary surgery. Only five patients have undergone definitive surgery. Definitive surgery included abdomino-perineal pull-through of proximal normal colon ( n =2, tubularization of pouch with abdomino- posterior sagittal- pull through ( n =2 and abdomino-posterior sagittal urethra-vaginoanorectoplasty with pull through of tapered pouch colon in one patient. Two of these patients had concomitant bowel vaginoplasty. Three patients with tubularized pouches had constipation and spurious diarrhea. However, good pseudo-continence of bowel was achieved on regular bowel washes. The cosmetic appearance of perineum in all these three patients was acceptable. The patients in whom pouch excision was done had diarrhea and severe perineal excoriation resistant to conservative management.

  9. Ants defend coffee from berry borer colonization

    OpenAIRE

    Gonthier, DJ; Ennis, KK; Philpott, SM; Vandermeer, J; Perfecto, I.

    2013-01-01

    Ants frequently prevent herbivores from damaging plants. In agroecosystems they may provide pest control services, although their contributions are not always appreciated. Here we compared the ability of eight ant species to prevent the coffee berry borer from colonizing coffee berries with a field exclusion experiment. We removed ants from one branch (exclusion) and left ants to forage on a second branch (control) before releasing 20 berry borers on each branch. After 24 h, six of eight spec...

  10. Experimental Colonic Obstruction and Anastomotic Healing

    OpenAIRE

    Rehn, Martin

    2012-01-01

    Colorectal cancer is one of the most common malignant diseases world-wide. Most patients can be diagnosed, staged and treated by surgery in an elective setting. However, about one fifth of the patients will have an emergency presentation and in most cases due to malignant obstruction of the left colon. Immediate resection and anastomosis is feasible but carries a 3-fold higher risk of developing anastomotic leakage compared to elective surgery. Anastomotic healing in patients can be evaluated...

  11. Diversity of the autochthonous colonic microbiota

    OpenAIRE

    Nava, Gerardo M.; Stappenbeck, Thaddeus S.

    2011-01-01

    A longstanding hypothesis in intestinal microbial ecology is that autochthonous microbes (resident) play a role that is distinct from allochthonous microbes (transient microbes in the fecal stream). A challenge has been to identify this pool of microbes. We used laser capture microdissection to collect microbes from the mouse ascending colon. This area contains transverse folds that mimic human intestinal folds and contains a distinct population of intestinal microbes that is associated with ...

  12. Human Colon Cancer Cells Cultivated in Space

    Science.gov (United States)

    1995-01-01

    Within five days, bioreactor cultivated human colon cancer cells (shown) grown in Microgravity on the STS-70 mission in 1995, had grown 30 times the volume of the control specimens on Earth. The samples grown in space had a higher level of cellular organization and specialization. Because they more closely resemble tumors found in the body, microgravity grown cell cultures are ideal for research purposes.

  13. The actinobacterial colonization of etruscan paintings

    OpenAIRE

    Marta Diaz-Herraiz; Valme Jurado; Soledad Cuezva; Leonila Laiz; Pasquino Pallecchi; Piero Tiano; Sergio Sanchez-Moral; Cesareo Saiz-Jimenez

    2013-01-01

    The paintings from Tomba della Scimmia, in Tuscany, are representative of the heavy bacterial colonization experienced in most Etruscan necropolises. The tomb remained open until the late 70′s when it was closed because of severe deterioration of the walls, ceiling and paintings after decades of visits. The deterioration is the result of environmental changes and impacts suffered since its discovery in 1846. We show scanning electron microscopy and molecular studies that reveal the extent and...

  14. Lactose intolerance: the role of colonic metabolism

    OpenAIRE

    He, Tao

    2006-01-01

    Dairy products provide us with calcium and other valuable nutrients. However, they also contain lactose which is maldigested by a large part of the world adult population. The mechanisms by which lactose maldigestion causes symptoms of lactose intolerance are not fully understood. Studies on the pathophysiology of lactose intolerance may aid to design strategies for dietary management of lactose intolerance. Limited evidence suggests that colonic metabolism of lactose, in addition to the smal...

  15. Fucose Sensing Regulates Bacterial Intestinal Colonization

    OpenAIRE

    Pacheco, Alline R.; Curtis, Meredith M.; Ritchie, Jennifer M; Munera, Diana; Matthew K Waldor; Moreira, Cristiano G.; Sperandio, Vanessa

    2012-01-01

    The mammalian gastrointestinal (GI) tract provides a complex and competitive environment for the microbiota 1 . Successful colonization by pathogens depends on scavenging nutrients, sensing chemical signals, competing with the resident bacteria, and precisely regulating expression of virulence genes 2 . The GI pathogen enterohemorrhagic E.coli (EHEC) relies on inter-kingdom chemical sensing systems to regulate virulence gene expression 3–4 . Here we show that these systems control the express...

  16. [Colonic microbial biocenosis in rheumatoid arthritis].

    Science.gov (United States)

    Gul'neva, M Iu; Noskov, S M

    2011-01-01

    The aim of the work was to study colonic microbial biocenosis and colonizing ability of opportunistic bacteria in 32 patients with rheumatoid arthritis (RA) and 30 healthy subjects. RA was diagnosed based on the American Rheumatism Association criteria (1987). Qualitative and quantitative composition of the microflora was detected by a bacteriological method. StatSoft Statistics 6.0 was used to treat the data obtained. RA was associated with significant modification of the intestinal flora, viz. decrease in lactobacteria and significant increase of enterococci, clostridia, colibacteria showing reduced enzymatic activity, and opportunistic species. Also, symbiotic relationships between microorganisms altered. The fraction of bifidobacteria, bacteroids, and lactopositive colibacteria reduced while the abundance of opportunistic enterobacteria and staphylococci was elevated. Opportunistic Enterobacteriaceae were present in urine and nasal mucosa which suggested their translocation from the intestines. It is concluded that changes in intestinal microflora and colonization by opportunistic bacteria enhance the risk of development of co-morbid conditions in patients with RA. PMID:21932563

  17. [Clinical practice using colon capsule endoscopy].

    Science.gov (United States)

    Kakugawa, Yasuo; Matsumoto, Minori; Saito, Yutaka

    2014-01-01

    PillCam COLON capsule endoscopy(CCE) (Given Imaging Ltd., Yoqneam, Israel) is one of the most recent diagnostic technologies designed to explore the colorectum. The first generation of CCE was released onto the market in 2006, and the second generation (PillCam COLON 2 : CCE-2), with increased sensitivity, was released in 2009. The CCE-2 has 2 imagers with a much wider angle of view that has been increased to 172 degrees per imager, allowing nearly 360 degrees coverage of the colon by two. The most unique feature of the CCE-2 is its adaptive frame rate (AFR). This new technology allows the CCE-2 to capture 35 images per second when in motion and 4 images per second when virtually stationary. The per-patient CCE-2 sensitivity for detecting polyps > or = 6 mm has been reported as 84%-91%. These recent advancements in this modality might offer physicians the option to screen for colorectal lesions noninvasively. PMID:24597367

  18. Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA

    International Nuclear Information System (INIS)

    Highlights: •Non-coding RNAs are found in the colonic crypt progenitor compartment. •Colonocytes transformed by ncNRFR are highly invasive and metastatic. •ncNRFR has a region similar to the miRNA, let-7 family. •ncNRFR expression alters let-7 activity as measured by reporter construct. •ncNRFR expression upregulates let-7b targets. -- Abstract: Recent progress has been made in the identification of protein-coding genes and miRNAs that are expressed in and alter the behavior of colonic epithelia. However, the role of long non-coding RNAs (lncRNAs) in colonic homeostasis is just beginning to be explored. By gene expression profiling of post-mitotic, differentiated tops and proliferative, progenitor-compartment bottoms of microdissected adult mouse colonic crypts, we identified several lncRNAs more highly expressed in crypt bottoms. One identified lncRNA, designated non-coding Nras functional RNA (ncNRFR), resides within the Nras locus but appears to be independent of the Nras coding transcript. Stable overexpression of ncNRFR in non-transformed, conditionally immortalized mouse colonocytes results in malignant transformation, as determined by growth in soft agar and formation of highly invasive tumors in nude mice. Moreover, ncNRFR appears to inhibit the function of the tumor suppressor let-7. These results suggest precise regulation of ncNRFR is necessary for proper cell growth in the colonic crypt, and its misregulation results in neoplastic transformation

  19. Antiproliferative effects of fluoxetine on colon cancer cells and in a colonic carcinogen mouse model.

    Directory of Open Access Journals (Sweden)

    Vinicius Kannen

    Full Text Available The antidepressant fluoxetine has been under discussion because of its potential influence on cancer risk. It was found to inhibit the development of carcinogen-induced preneoplastic lesions in colon tissue, but the mechanisms of action are not well understood. Therefore, we investigated anti-proliferative effects, and used HT29 colon tumor cells in vitro, as well as C57BL/6 mice exposed to intra-rectal treatment with the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG as models. Fluoxetine increased the percentage of HT29 cells in the G(0/G(1 phase of cell-cycle, and the expression of p27 protein. This was not related to an induction of apoptosis, reactive oxygen species or DNA damage. In vivo, fluoxetine reduced the development of MNNG-induced dysplasia and vascularization-related dysplasia in colon tissue, which was analyzed by histopathological techniques. An anti-proliferative potential of fluoxetine was observed in epithelial and stromal areas. It was accompanied by a reduction of VEGF expression and of the number of cells with angiogenic potential, such as CD133, CD34, and CD31-positive cell clusters. Taken together, our findings suggest that fluoxetine treatment targets steps of early colon carcinogenesis. This confirms its protective potential, explaining at least partially the lower colon cancer risk under antidepressant therapy.

  20. Selling space colonization and immortality: A psychosocial, anthropological critique of the rush to colonize Mars

    Science.gov (United States)

    Slobodian, Rayna Elizabeth

    2015-08-01

    Extensive media coverage regarding the proposal to send four people to Mars by 2025 has exploded recently. Private enterprise has taken the reins to venture into space, which has typically only been reserved for government agencies. I argue, that with this new direction comes less regulation, raising questions regarding the ethics of sending people into outer space to colonize Mars within a decade. Marketers selling colonization to the public include perspectives such as biological drives, species survival, inclusiveness and utopian ideals. I challenge these narratives by suggesting that much of our desire to colonize space within the next decade is motivated by ego, money and romanticism. More specifically, I will examine the roles that fear and stories of immortality play within selling space and how those stories are marketed. I am passionate about space and hope that one day humanity will colonize other worlds, but the rush to settle is dangerous and careless. I assert that humanity should first gain more experience and knowledge before colonizing outer space, using this research to mitigate the risk to astronauts and proceed with careful consideration for the lives of potential astronauts.

  1. FasL EXPRESSION IN HUMAN COLON CARCINOMAS

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective:The Fas and Fas ligand (FasL) play an important role in maintaining immune privilege on malignant tumors. In present study, we investigated the expression of FasL in SW480 and LS174 human colon carcinoma cell lines and twenty primary colon carcinoma specimens. Methods: The expression of FasL in human colon carcinoma cell lines and primary colon carcinomas specimens was detected by immunohistochemistry and Reverse Transcription-PCR (RT-PCR). Results: We found that all of detected human colon carcinoma cell lines and primary colon carcinoma specimens constitutively expressed FasL at the mRNA and protein level. However, the expression of FasL was not found in normal colon epithelial cells. Conclusion: The expression of FasL may occur during malignant transformation from normal colon epithelial cells to colon carcinoma cells. Our results suggest that tumor cells kill cytotoxic T lymphocytes (CTLS) and natural killer (NK) cells by expression of FasL. It may be a new mechanism for tumor cells to escape the host's immune surveillance. The expression of FasL may contribute to the formation of colon carcinomas.

  2. Normal human colon cells suppress malignancy when fused with colon cancer cells

    International Nuclear Information System (INIS)

    Normal human colon mucosa cells and cells obtained from histologically normal tissues near that cancer were fused with human colon cancer cells. Resultant hybrid populations of normal and malignant cell fusions behaved as nonmalignant cells in culture, were unable to grow in soft agar, did not express tumor-associated antigens, and were nontumorigenic in nude mice. Autofusion of the cancer cell population led to a phenotype intermediate between normal and malignant cells. That is, the cultures had a much lower plating efficiency in soft agar, and the tumors had a longer latency and slower growth rate in nude mice. This is the first cell culture system to demonstrate that normal epithelial cells can suppress malignancy of their autologous cancer cells, and is a prelude to more extensive studies of genetic events involved in malignant conversion of human colonic epithelium

  3. Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis.

    LENUS (Irish Health Repository)

    Rowan, Fiachra

    2012-02-01

    OBJECTIVE: To optimize total bacterial 16S rRNA quantification in microdissected colonic crypts in healthy controls and patients with ulcerative colitis (UC) and to characterize the findings with disease activity. BACKGROUND: Microscopic and molecular techniques have recently converged to allow bacterial enumeration in remote anatomic locations [eg, crypt-associated mucous gel (CAMG)]. The aims of this study were to combine laser capture microdissection (LCM) and 16S rRNA-based quantitative polymerase chain reaction (qPCR) to determine total bacterial copy number in CAMG both in health and in UC and to characterize the findings with disease activity. METHODS: LCM was used to microdissect CAMG from colonic mucosal biopsies from controls (n = 20) and patients with acute (n = 10) or subacute (n = 10) UC. Pan-bacterial 16S rRNA copy number per millimeter square in samples from 6 locations across the large bowel was obtained by qPCR using Desulfovibrio desulfuricans as a reference strain. Copy numbers were correlated with the UC disease activity index (UCDAI) and the simple clinical colitis activity index (SCCAI). RESULTS: Bacterial colonization of CAMG was detectable in all groups. Copy numbers were significantly reduced in acute UC. In subacute colitis, there was a positive correlation between copy number and UCDAI and SCCAI in the ascending, transverse and sigmoid colon. CONCLUSIONS: This study describes a sensitive method of quantitatively assessing bacterial colonization of the colonic CAMG. A positive correlation was found between CAMG bacterial load and subacute disease activity in UC, whereas detectable bacterial load was reduced in acute UC.

  4. Determination of Normal Distribution of Distended Colon Volumes to Guide Performance of Colonic Imaging With Fluid Distention.

    Science.gov (United States)

    Zheng, Karen S; Small, William C; Mittal, Pardeep K; Cai, Qingpo; Kang, Jian; Moreno, Courtney C

    2016-01-01

    The purpose was to determine the normal distribution of distended colon volumes as a guide for rectal contrast material administration protocols. All computed tomography colonography studies performed at Emory University Hospital, Atlanta, Georgia, between January 2009 and January 2015, were reviewed retrospectively. In total, 85 subjects were included in the analysis (64% [54 of 85] female and 36% [31 of 85] male). Mean patient age was 65 years (range: 42-86y). Distended colon volumes were determined from colon length and transaxial diameter measurements made using a 3-dimensional workstation. Age, sex, race, height, weight, and body mass index were recorded. The normal distributions of distended colon volumes and lengths were determined. Correlations between colonic volume and colonic length, and demographic variables were assessed. Mean colon volume was 2.1L (range: 0.7-4.4L). Nearly, 17% of patients had a distended colonic volume of >3L. Mean colon length was 197cm (range: 118-285cm). A weak negative correlation was found between age and colonic volume (r = -0.221; P = 0.04). A weak positive correlation was found between body mass index and colonic length (r = 0.368; P = 0.007). Otherwise, no significant correlations were found for distended colonic volume or length and demographic variables. In conclusion, an average of approximately 2L of contrast material may be necessary to achieve full colonic opacification. This volume is larger than previously reported volumes (0.8-1.5L) for rectal contrast material administration protocols. PMID:26684578

  5. Nutraceuticals as potential therapeutic agents for colon cancer: a review

    Directory of Open Access Journals (Sweden)

    Palaniselvam Kuppusamy

    2014-06-01

    Full Text Available Colon cancer is a world-wide health problem and the second-most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel and environmentally benign drug therapies for colon cancer. Currently, nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer, diabetes and Alzheimer׳s disease. Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits. Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression. These dietary substances target different molecular aspects of colon cancer development. Accordingly, this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis.

  6. A new electronic colon cleansing method for virtual colonoscopy

    Science.gov (United States)

    Li, Lihong; Wang, Su; Wang, Jing; Eremina, Daria; Wei, Xinzhou; Liang, Zhengrong

    2007-03-01

    Virtual colonoscopy has been developed as a non-invasive, safe, and low-cost method to evaluate colon polyps. Implementation and efficiency of virtual colonoscopy requires rigorous cleansing of colon prior to the examination. Electronic colon cleansing is a new technology that virtually clean stool residues tagged with contrast agents from the obtained computed tomography (CT) images. From our previous studies on electronic colon cleansing, we found that residual stool and fluid are often problematic for optimal viewing of colon. In this paper, we focus on developing a model-based approach to correct both non-uniformity and partial volume effects appearing in regions of bone and tagged stool residues. A statistical method for maximum a posterior probability (MAP) was developed to identify and virtually clean the tagged stool residuals. In calculating the solution, the well-known expectation maximization (EM) algorithm is employed. Experimental results of electronic colon cleansing are promising.

  7. Role of dietary factors in cell replication and colon cancer.

    Science.gov (United States)

    Jacobs, R

    1988-09-01

    Human studies and experimental data from animals suggest that high rates of colonic epithelial cell replication enhance the development of colon cancer. Vegetarians and individuals following a prudent diet have lower rates of colorectal cell proliferation than subjects at high risk for colon cancer. Animal studies show that colonic cell proliferation is stimulated by feeding in general and specifically by a number of dietary fibers, fats, bile acids, and short-chain fatty acids. Many of these growth factors also increase the induction of experimental tumorigenesis. On the other hand factors that reduce cell growth, including ascorbic acid and butylated hydroxyanisole, inhibit colon carcinogenesis. These results support the concept that dietary chemoprevention is feasible and could significantly reduce the rate of colon cancer development in high risk populations. PMID:3046307

  8. Monograph of Arctium L. (Asteraceae). Generic delimitation (including Cousinia Cass, p.p.), revision of the species, pollen morphology, and hybrids

    OpenAIRE

    Duistermaat, Helena

    1996-01-01

    The subject of this thesis is a monograph of the genus Arctium, now including also five species formerly placed into Cousinia. Based on herbarium material and some field observations, this study presents new insights on three subjects: a) the generic delimitation of Arctium, b) the species delimitation within the A. minus-complex, and c) the occurrence of hybridisation. It soon became clear, rather surprisingly, that five species of Cousinia possess hooked involucral bracts like Arctium in it...

  9. Modified Approaches for Colon Specific Drug Delivery System: A Review

    Directory of Open Access Journals (Sweden)

    Ritesh Kumar1*, Amrish Chandra2, Pawan Kumar Gautam3

    2013-09-01

    Full Text Available The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topicaltreatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeteddirectly into the colon, thereby reducing the systemic side effects. This review mainly describes the primaryapproaches for CDDS (Colon Specific Drug Delivery namely prodrugs, pH and time dependent systems, andmicrobially triggered systems, which achieved limited success and had limitations as compared with newer CDDSnamely pressure controlled colonic delivery capsules. Oral administration of different dosage forms is the mostcommonly used method due to flexibility in design of dosage form and high patient acceptance, but thegastrointestinal tract presents several formidable barriers to drug delivery. In oral colon-specific drug deliverysystem, colon has a large amount of lymphoma tissue (facilitates direct absorption in to the blood, negligible brushboarder membrane activity, and much less pancreatic enzymatic activity as compared with the small intestine.Colon-specific drug delivery has gained increased importance not just for the delivery of the drugs for treatment oflocal diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides.Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency (lag time,microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules,multiparticulates, microspheres, liposomes for colon targeting. The delivery of drugs to the colon has a number oftherapeutic implications in the field of drug delivery. In the recent times, the colon specific delivery systems are alsogaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein and peptidedrugs. This review updated the research on different approaches formulation and

  10. Journey of a Swallowed Toothbrush to the Colon

    OpenAIRE

    Kim, In Hee; Kim, Hyun Chul; Koh, Kang Hun; Kim, Seong Hun; Kim, Sang Wook; Lee, Seung Ok; Lee, Soo Teik

    2007-01-01

    Toothbrush swallowing is a rare event. Because no cases of spontaneous passage have been reported, prompt removal is recommended to prevent the development of complications. Most swallowed toothbrushes have been found in the esophagus or the stomach of affected patients, and there has been no previously reported case of a toothbrush in the colon. Here, we report a case of a swallowed toothbrush found in the ascending colon that caused a fistula between the right colon and the liver, with a co...

  11. Arteria1 microvascularization and breast cancer colonization in bone

    OpenAIRE

    Yoneda, T

    1997-01-01

    Bone is one of the most preferential target organs of cancer metastases. Breast, prostate and lung cancers have a special predilection for colonization in bone. In an animal model in which inoculation of cancer cells into the left cardiac ventricle selectively develops osteolytic bone metastases but rarely forms metastases in non-bone organs, the pattern of breast cancer colonization in bone was studied radiologically and histologically. Colonization of cancer ...

  12. Multiparticulate system for colon targeted delivery of ondansetron

    OpenAIRE

    Jose S; Dhanya K; Cinu T; Aleykutty N

    2010-01-01

    Targeted delivery of drugs to colon has the potential for local treatment of a variety of colonic diseases. The main objective of the study was to develop a multiparticulate system containing chitosan microspheres for the colon targeted delivery of ondansetron for the treatment of irritable bowel syndrome. This work combines pH-dependent solubility of eudragit S-100 polymers and microbial degradability of chitosan polymers. Chitosan microspheres containing ondansetron were prepared by emulsio...

  13. Nutraceuticals as potential therapeutic agents for colon cancer: a review

    OpenAIRE

    Palaniselvam Kuppusamy; Yusoff, Mashitah M.; Gaanty Pragas Maniam; Solachuddin Jauhari Arief Ichwan; Ilavenil Soundharrajan; Natanamurugaraj Govindan

    2014-01-01

    Colon cancer is a world-wide health problem and the second-most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel and environmentally benign drug therapies for colon cancer. Currently, nutraceuticals play an increasingly important role in the treatment o...

  14. Adjuvant Therapy of Colon Cancer: Current Status and Future Developments

    OpenAIRE

    Morse, Michael A.

    2005-01-01

    Options for the adjuvant therapy of resected stage III colon cancer have expanded beyond the previously well-accepted standard of 5-fluorouracil (5-FU) combined with leucovorin. The Xeloda in Adjuvant Colon Cancer Therapy (X-ACT) study confirmed that capecitabine (Xeloda) is at least as effective and is less toxic than a bolus 5-FU and leucovorin regimen for patients with stage III colon cancer. This study, in addition to National Surgical Adjuvant Breast and Bowel Project (NSABP) C-06, which...

  15. Simultaneous Resection of Disseminated Hepatocellular Carcinoma and Colon Cancer

    OpenAIRE

    Haga, Yuki; Chiba, Tetsuhiro; Ohira, Gaku; Kanai, Fumihiko; Yokota, Hajime; Motoyama, Tenyu; Ogasawara, Sadahisa; Suzuki, Eiichiro; Ooka, Yoshihiko; Tawada, Akinobu; Miyauchi, Hideaki; Matubara, Hisahiro; Yokosuka, Osamu

    2013-01-01

    A 75-year-old woman with abdominal pain and vomiting was admitted to our hospital. Colonoscopy showed an advanced colon cancer that encompassed the entire circumference of the descending colon's lumen. The patient was diagnosed with occlusive ileus associated with the colon cancer. She had been watched for liver cirrhosis due to the hepatitis C virus and received radiofrequency ablation therapy for hepatocellular carcinoma (HCC) 6 years previously. Although she exhibited a gradual increase in...

  16. The social structure of microbial community involved in colonization resistance

    OpenAIRE

    He, Xuesong; McLean, Jeffrey S.; Guo, Lihong; Lux, Renate; Shi, Wenyuan

    2013-01-01

    It is well established that host-associated microbial communities can interfere with the colonization and establishment of microbes of foreign origins, a phenomenon often referred to as bacterial interference or colonization resistance. However, due to the complexity of the indigenous microbiota, it has been extremely difficult to elucidate the community colonization resistance mechanisms and identify the bacterial species involved. In a recent study, we have established an in vitro mice oral...

  17. Bicarbonate secretion by rabbit proximal colon.

    Science.gov (United States)

    Sullivan, S K; Smith, P L

    1986-10-01

    Stripped segments of proximal colon (1-6 cm distal to the ampulla caecalis coli) were studied in vitro in Ussing chambers under short-circuit conditions using the pH-stat technique. With glucose and HCO3-CO2 present in the serosal bathing solution only, proximal colon alkalinizes the luminal bathing solution at a rate of 2.1 +/- 0.2 mu eq X h-1 X cm-2 (n = 36). With HCO3-CO2 present in the luminal bathing solution alone, proximal colon does not significantly acidify or alkalinize the serosal bathing solution. Addition of glucose (10 mM) to the luminal bathing solution abolished luminal alkalinization. Removal of HCO3 and CO2 from the serosal bathing solution or replacement of O2 with N2 also abolished luminal alkalinization. Acetazolamide (0.1 mM) added to both bathing solutions did not alter the rate of luminal alkalinization. Ion-replacement studies revealed that the alkalinization process was highly dependent on the presence of Na in the bathing solutions and much less dependent on the presence of Cl. Furthermore, ouabain (0.1 mM) significantly reduced luminal alkalinization. As in rabbit ileum, serosal epinephrine (0.1 mM) did not alter luminal alkalinization but increased serosal alkalinization by a Na-dependent mechanism. These results suggest that luminal alkalinization results from a Na-dependent, active transcellular HCO3 transport process and that a Na-dependent HCO3 absorptive process is activated by adrenergic stimuli. PMID:3766731

  18. Bacterial and fungal colonization of burn wounds

    Directory of Open Access Journals (Sweden)

    Jefferson Lessa Soares de Macedo

    2005-08-01

    Full Text Available A prospective study of fungal and bacterial flora of burn wounds was carried out from February 2004 to February 2005 at the Burns Unit of Hospital Regional da Asa Norte, Brasília, Brazil. During the period of the study, 203 patients were treated at the Burns Unit. Wound swab cultures were assessed at weekly intervals for four weeks. Three hundred and fifty four sampling procedures (surface swabs were performed from the burn wounds. The study revealed that bacterial colonization reached 86.6% within the first week. Although the gram-negative organisms, as a group, were more predominant, Staphylococcus aureus (28.4% was the most prevalent organism in the first week. It was however surpassed by Pseudomonas aeruginosa form third week onwards. For S. aureus and P. aeruginosa vancomycin and polymyxin were found to be the most effective drugs. Most of the isolates showed high level resistance to antimicrobial agents. Fungi were found to colonize the burn wound late during the second week postburn, with a peak incidence during the third and fourth weeks. Species identification of fungi revealed that Candida tropicalis was the most predominant, followed by Candida parapsilosis. It is crucial for every burn institution to determine the specific pattern of burn wound microbial colonization, the time-related changes in the dominant flora, and the antimicrobial sensitivity profiles. This would enable early treatment of imminent septic episodes with proper empirical systemic antibiotics, without waiting for culture results, thus improving the overall infection-related morbidity and mortality.

  19. Fast evolutionary genetic differentiation during experimental colonizations

    Indian Academy of Sciences (India)

    Josiane Santos; Marta Pascual; Pedro Simões; Inês Fragata; Michael R. Rose; Margarida Matos

    2013-08-01

    Founder effects during colonization of a novel environment are expected to change the genetic composition of populations, leading to differentiation between the colonizer population and its source population. Another expected outcome is differentiation among populations derived from repeated independent colonizations starting from the same source. We have previously detected significant founder effects affecting rate of laboratory adaptation among Drosophila subobscura laboratory populations derived from the wild. We also showed that during the first generations in the laboratory, considerable genetic differentiation occurs between foundations. The present study deepens that analysis, taking into account the natural sampling hierarchy of six foundations, derived from different locations, different years and from two samples in one of the years. We show that striking stochastic effects occur in the first two generations of laboratory culture, effects that produce immediate differentiation between foundations, independent of the source of origin and despite similarity among all founders. This divergence is probably due to powerful genetic sampling effects during the first few generations of culture in the novel laboratory environment, as a result of a significant drop in $N_{\\text{e}}$. Changes in demography as well as high variance in reproductive success in the novel environment may contribute to the low values of $N_{\\text{e}}$. This study shows that estimates of genetic differentiation between natural populations may be accurate when based on the initial samples collected in the wild, though considerable genetic differentiation may occur in the very first generations of evolution in a new, confined environment. Rapid and significant evolutionary changes can thus occur during the early generations of a founding event, both in the wild and under domestication, effects of interest for both scientific and conservation purposes.

  20. REVIEW ON ADVANCES IN COLON TARGETED DRUG DELIVERY SYSTEM

    Directory of Open Access Journals (Sweden)

    Sunena Sethi, SL Harikumar* and Nirmala

    2012-09-01

    Full Text Available The colon is the terminal part of the GIT which has gained in recent years as a potential site for delivery of various novel therapeutic drugs, i.e. peptides. However, colon is rich in microflora which can be used to target the drug release in the colon. Colon is a site where both local and systemic drug delivery can take place. Local delivery allows the topical treatment of inflammatory bowel disease. If drug can be targeted directly into the colon, treatment can become more effective and side effects can be minimized. These systemic side effects can be minimized by primary approaches for CDDS (Colon specific drug delivery namely prodrugs, pH and time dependent systems and microbially triggered system which gained limited success and have limitations as compared with recently new CDDS namely pressure controlled colon delivery capsules (PCDCS, CODESTM (Novel colon targeted delivery system osmotic controlled drug delivery system, Pulsincap system, time clock system, chronotropic system. This review is to understand the pharmaceutical approaches to colon targeted drug delivery systems for better therapeutic action without compromising on drug degradation (or its low bioavailability.

  1. THE COLONIC TRANSIT TEST IN THE ASSESSMENT OF CHRONIC CONSTIPATION

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    In order to assess colonic motility of chronic constipation, colonic transit test was carried out in 34 patients with chronic constipation and in 20 healthy subjects. 20 radiopaque markers are ingested at 8 am before the day test, and plain abdominal films were obtained at 24 h, 48 h and 72 h. The normal value of colonic transit test was 16(80%), or more markers passed after 72 h. By means of transit time study, 34 constipated patients were classified into 2 groups: 12 normal transit patients and 22 slow transit patients. There was no difference in colonic transit time between normal transit patients and controls (P>0.05). Patients with slow transit had more markers left in right colon, left colon and rectosigmoid colon at 48 h (P<0.01, respectively) and 72 h (P<0.01, respectively). According to the transit index, 22 slow transit patients were divided into 3 types: 10 cases colonic stasis, 8 cases outlet obstruction and 4 cases colorectal stasis. The study suggests that chronic constipated patients have abnormalbilities of colonic transit.

  2. COX MULTIVARIATE REGRESSION ANALYSIS OF RECURRENCE FACTORS FOR COLONIC CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    杜寒松; 王国斌; 秦青平; 夏玉春; 司徒光伟

    2004-01-01

    Objective: To determine the independent prognostic factors in the recurrence of colonic carcinoma after curative resection. Methods: Two hundred and one patients undergoing curative resections for colonic carcinoma were investigated by univariate and Cox multivariate regression analyses. Ten factors contributed to the rate were analyzed. Results: Dukes stages, obstruction, postoperative chemotherapy as well as the growth manner of the tumor were significantly associated with the recurrence rate of colonic carcinoma (P<0.05) by univariate analysis, while Dukes stages, obstruction, and postoperative chemotherapy were significant factors by the multivariate analysis. Conclusion: Dukes stages, obstruction, and postoperative chemotherapy are independent prognostic factors in the recurrence of colonic carcinoma.

  3. Colonic diverticulitis in adolescents: an index case and associated syndromes.

    Science.gov (United States)

    Santin, Brian J; Prasad, Vinay; Caniano, Donna A

    2009-10-01

    Diverticular disease of the colon, a common problem among adults, is diagnosed rarely in children. We report an adolescent patient with sigmoid diverticulitis who required operative treatment. Pediatric patients with the complications of diverticula typically have conditions that result in genetic alterations affecting the components of the colonic wall. Our patient had Williams-Beuren syndrome, although Ehlers-Danlos syndrome, Marfan syndrome, and cystic fibrosis may also be associated with colonic diverticula in adolescence. Pediatric patients with these disorders who experience abdominal pain should be evaluated for the presence of colonic diverticular complications. PMID:19711089

  4. Delirium in fast-track colonic surgery

    DEFF Research Database (Denmark)

    Kurbegovic, Sorel; Andersen, Jens; Krenk, Lene; Kehlet, Henrik

    2015-01-01

    BACKGROUND: Postoperative delirium (PD) is a common but serious problem after major surgery with a multifactorial pathogenesis including age, pain, opioid use, sleep disturbances and the surgical stress response. These factors have been minimised by the "fast-track methodology" previously...... demonstrated to enhance recovery and reduce morbidity. METHODS: Clinical symptoms of PD were routinely collected three times daily from preoperatively until discharge in a well-defined enhanced recovery program after colonic surgery in 247 consecutive patients. RESULTS: Total median length of hospital stay was...

  5. Interstellar colonization and the zoo hypothesis

    Energy Technology Data Exchange (ETDEWEB)

    Jones, E.M.

    1978-01-01

    Michael Hart and others have pointed out that current estimates of the number of technological civilizations arisen in the Galaxy since its formation is in fundamental conflict with the expectation that such a civilization could colonize and utilize the entire Galaxy in 10 to 20 million years. This dilemma can be called Hart's paradox. Resolution of the paradox requires that one or more of the following are true: we are the Galaxy's first technical civilization; interstellar travel is immensely impractical or simply impossible; technological civilizations are very short-lived; or we inhabit a wildnerness preserve. The latter is the zoo hypothesis. (GHT)

  6. Diverticulosis of the colon and complications

    International Nuclear Information System (INIS)

    Colonic diverticula in reality are herniations of the mucosa through a thickened musculature of the bowel wall where it is penetrated by the vasa recta. Their prevalence increases with western food and with age. Low-residue diet and increased intraluminal pressure are considered to be etiologic factors. Diverticular disease is characterised by inflammatory and bleeding complications. Diverticulitis may lead to peridiverticulitis and pericolitis with frank peritonitis. Uncomplicated diverticulosis warrants observation only under dietary guidance. Repeated complications indicate elective operation by one-stage-resection. Perforation, abscess and massive bleeding necessitate immediate operative treatment aimed at elimination of the involved segment. (orig.)

  7. Interstellar colonization and the zoo hypothesis

    International Nuclear Information System (INIS)

    Michael Hart and others have pointed out that current estimates of the number of technological civilizations arisen in the Galaxy since its formation is in fundamental conflict with the expectation that such a civilization could colonize and utilize the entire Galaxy in 10 to 20 million years. This dilemma can be called Hart's paradox. Resolution of the paradox requires that one or more of the following are true: we are the Galaxy's first technical civilization; interstellar travel is immensely impractical or simply impossible; technological civilizations are very short-lived; or we inhabit a wildnerness preserve. The latter is the zoo hypothesis

  8. Congenital pouch colon in female subjects

    OpenAIRE

    Sarin Y; Nagdeve N; Sengar M

    2007-01-01

    Over a period of 5-year (May 2000 to April 2005) 29 patients of congenital pouch colon (CPC) were managed by single pediatric surgeon in the Department of Pediatric Surgery of a tertiary hospital. Of these, 11 were girls (M: F: 1.6:1). Detailed anatomy could be studied in nine patients, were included in this study. Age of presentation in female subjects ranged 1 day to 8 years. On examination, eight of the nine patients had single perineal opening suggesting a very high incidence of associati...

  9. Communication strategies for colonization mission to Mars

    OpenAIRE

    Machuca Varela, Pablo Antonio

    2015-01-01

    Earth-Mars cycler trajectories could be used as a periodic and cost-efficient human transportation system from Earth to Mars in a future mission to colonize Mars. Continuous and reliable communication between Mars and the Earth will be required in such a mission. In a circular-coplanar model, the existance of a particularly interesting cycler trajectory (ballistic outbound Earth-Mars S1L1 cycler trajectory) is proven, which has relatively short Earth-Mars transfer times, low relative velociti...

  10. Clinical roundtable monograph: Recent advances in the treatment of mantle cell lymphoma: a post-ASH 2009 discussion.

    Science.gov (United States)

    Czuczman, Myron S; Leonard, John P; Williams, Michael E

    2010-04-01

    Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma characterized by CD5 expression and a t(11;14) cytogenetic translocation that results in overexpression of the cyclin D1 gene. Currently, there is no standard of care for the treatment of MCL, and patient prognosis is poor. Traditional treatments for MCL rely on conventional chemotherapy agents, including cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). The addition of the immunotherapeutic agent rituximab to this regimen (CHOP-R) has helped to improve patient response to treatment. These treatments often provide good initial responses that are difficult to sustain. Therefore, a number of newer agents and combinations have been investigated to produce more durable benefit. Several of these advances were reported at the 51st American Society of Hematology (ASH) Annual Meeting and Exposition, held December 5-8, 2009 in New Orleans, Louisiana. In this clinical roundtable monograph, new strategies in the treatment of MCL are discussed. Some of the drug classes examined here are proteasome inhibitors, inhibitors of the protein mammalian target of rapamycin (mTOR), the unique alkylating agent bendamustine, and immunomodulatory agents. PMID:20539272

  11. DEVELOPMENT OF METHOD OF QUALITATIVE ANALYSIS OF BIRD CHERRY FRUIT FOR INCLUSION IN THE MONOGRAPH OF STATE PHARMACOPOEIA OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Lenchyk L.V.

    2016-06-01

    Full Text Available Introduction. Bird cherry Padus avium Mill, Rosaceae, is widespread in Ukraine, especially in forests and forest-steppe areas. Bird cherry fruits have long been used in medicine and is a valuable medicinal raw materials. They stated to posess astringent, anti-inflammatory, phytoncidal properties. Bird cherry fruits are included in the USSR Pharmacopoeia IX ed., The State Pharmacopoeia of the Russian Federation, The State Pharmacopoeia of Republic of Belarus. In Ukraine there are no contemporary normative documents for this medicinal plant material, therefore it is the actual to develop projects in the national monographs "dry bird cherry fruit" and "fresh bird cherry fruit" to be included in the State Pharmacopoeia of Ukraine. According to European Pharmacopoeia recommendation method of thin-layer chromatography (TLC is prescribed only for the identification of the herbal drug. The principles of thin-layer chromatography and application of the technique in pharmaceutical analysis are described in State Pharmacopoeia of Ukraine. As it is effective and easy to perform, and the equipment required is inexpensive, the technique is frequently used for evaluating medicinal plant materials and their preparations. The TLC is aimed at elucidating the chromatogram of the drug with respect to selected reference compounds that are described for inclusion as reagents. Aim of this study was to develop methods of qualitative analysis of bird cherry fruits for a monograph in the State Pharmacopoeia of Ukraine (SPU. Materials and Methods. The object of our study was dried bird cherry fruits (7 samples and fresh bird cherry fruits (7 samples harvested in 2013-2015 in Kharkiv, Poltava, Luhansk, Sumy, Lviv, Mykolaiv regions and the city Mariupol. Samples were registered in the department of SPU State Enterprise "Pharmacopeia center". In accordance with the Ph. Eur. and SPU requirements in "identification C" determination was performed by TLC. TLC was performed on

  12. Molecular Analysis of the Microbial Diversity Present in the Colonic Wall, Colonic Lumen, and Cecal Lumen of a Pig

    OpenAIRE

    Pryde, Susan E.; Anthony J. Richardson; Stewart, Colin S.; Flint, Harry J.

    1999-01-01

    Random clones of 16S ribosomal DNA gene sequences were isolated after PCR amplification with eubacterial primers from total genomic DNA recovered from samples of the colonic lumen, colonic wall, and cecal lumen from a pig. Sequences were also obtained for cultures isolated anaerobically from the same colonic-wall sample. Phylogenetic analysis showed that many sequences were related to those of Lactobacillus or Streptococcus spp. or fell into clusters IX, XIVa, and XI of gram-positive bacteria...

  13. [Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia].

    Science.gov (United States)

    Di Girolamo, G; Franchi, A; De Los Santos, A R; Martí, M L; Farina, M; Fernández de Gimeno, M A

    2001-01-01

    Lysine clonixinate (LC) is a nonsteroidal anti-inflammatory drug (NSAID) with good gastrointestinal tolerance. Treatment with LC at levels equivalent to those found in plasma following therapeutic doses resulted in significant inhibition of both cyclooxygenase 2 (COX-2) and production of 5 hydroxy-eicosatetraeonic acid (5-HETE) and slightly affected levels of cyclooxygenase 1 (COX-1) in in vitro studies carried out on human tissues. This study deals with the in vivo effect of the drug on human colon segments. Experiment 1: Five patients about to undergo hemicholectomy due to colon neoplasia were treated preoperatively with a continuous infusion of LC, to achieve a steady-state concentration between 4 and 6 mg/ml. Human colon segments from the five patients and from another five control patients receiving no treatment with [14C]-arachidonic acid were incubated. Human colon segments treated with LC showed significant inhibition of PGE2, the only prostaglandin (PG) synthesised by the tissue, as well as of 5-HETE. Experiment 2: Fifteen patients received an i.v. bolus of LC 100 mg (n1 = 5); LC 200 mg (n2 = 5) or indomethacin (INDO) 50 mg (n3 = 5). Both doses of LC showed greater inhibition of PGE2 synthesis than the INDO bolus. Both NSAIDs studied proved to have different effects on the production of 5-HETE; while treatment with LC elicited significant inhibition, levels with INDO remained unchanged. Western blotting analysis showed expression of both COX isoforms in colon segments, COX-2 levels being 20% higher. Both types of in vivo studies conducted continuous infusion and i.v. bolus, revealed that LC exerted significant inhibition of basal synthesis of PGE2 and 5-HETE. PMID:11721323

  14. Visualization of human colon carcinoma with 131I-antibodies to β1MA colonic antigen in experiment

    International Nuclear Information System (INIS)

    131I-antibodies to human β1 colonic antigen was administrated i.v. to nude mice with transplanted human colon carcinoma. Injections were followed by mouse whole-body investigation with the help of a gamma-camera and scanner. The distribution of radioactivity in murine tissues was investigated with a gamma-counter. Sharp images of tumor were obtained with the help of the gamma-camera and scanner. The results of visualization were in accord with radioimmunometric data. A conclusion was made of effective visualization of human colon carcinima transplanted to nude mice using iodinated antibodies to specific β1MA epithelial colonic antigen

  15. Diet and epigenetics in colon cancer

    Institute of Scientific and Technical Information of China (English)

    Minna Nystr(o)m; Marja Mutanen

    2009-01-01

    Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer.(c) 2009 The WJG Press and Baishideng. All rights reserved.

  16. Gaia and the colonization of Mars

    Science.gov (United States)

    Margulis, L.; West, O.

    1993-01-01

    The Gaia hypothesis states that the atmosphere, hydrosphere, surface sediments, and life on Earth behave dynamically as a single integrated physiological system. What has been traditionally viewed as the passive environment is a highly active, integral part of the gaian system. Aspects of the surface temperature and chemistry are regulated by the sum of life, the biota. Formulated first by James E. Lovelock, in the late 1960s, the Gaia hypothesis has been in the scientific literature for more than 25 years. Because of its properties of exponential growth and propagation, life is a powerful geologic force. A useful aspect of the Gaia idea is that it requires integration of scientific disciplines for the study of Earth. The recently touted Earth system science is broadly parallel with the gaian concept of the physiochemical regulation of Earth's surface. We discuss here, in a gaian context, the colonization of Mars by Earth organisms. Although colonizing Mars may be impossible, its accomplishment would be exactly equivalent to "the reproduction of Gaia by budding.".

  17. [Colonic microenvironment in familial helicobacter infection].

    Science.gov (United States)

    Shcherbakov, P L; Vorob'ev, A A; Nesvizhskiĭ, Iu V; Mitrokhin, S D; Kudriavtseva, L V; Minaev, V I; Filin, V A; Petrova, N N; Zaĭtseva, S V

    1998-01-01

    To elucidate the significance of the familial microenvironment in the genesis of Helicobacter infection, a clinical and instrumental investigation was made of 13 families selected by the probands who had digestive diseases associated with H. pylori: gastroduodenitis and duodenal ulcer disease. The occurrence of Helicobacter infection and gastritis in the family members was ascertained to be largely determined by their concurrent residence in the limited area, i.e. by the way of life. The contribution of the "family" factor in antral gastritis, fundal gastritis, and H. pylori infection was 60.0, 40.0, and about 90.0%, respectively. The patients with gastroenterological abnormalities associated with H. pylori were found to show changes in the species-specific and quantitative composition of the colonic microbiocenosis, which were symptomatic and revealed by bacteriological studies in 47.5% of cases and severe in 32.5%. When antihelicobacter therapy is planned, a through treatment of all family members and, if possible, pets should be made. Colonic microbiocenosis should be monitored while treating Helicobacter infection. PMID:9662996

  18. Synchronous colon and renal cancer - case report

    International Nuclear Information System (INIS)

    Primary cancer may occur synchronously in two different organs. We present an example of pathologically proven, coexistent renal and colony double malignant tumors. A 59 year old man, was admitted to the Institute of Oncology due to left renal lesion, discovered during a routine abdominal ultrasound examination. The CT exam was performed before surgery. The CT scans reveled a second abnormality, presenting irregular shaped and thickened to 20 mm intestinal wall within a patient's large bowel. As a next diagnostic step a CT-colonoscopy was undertaken, which confirmed the presence of an exophytic sigmoid lesion, eccentrically affecting the colonic wall and protruding into the lumen moderately narrowing it, placed about 50 cm from the external rectal sphincter. Patient underwent simultaneous radical left nephrectomy and sigmoidectomy. Both tumors were confirmed in pathologic evaluation, reveling renal clear cell carcinoma (Fuhrman G II) and colonic adenocarcinoma (Astler-Coller B2). Preoperative careful imaging studies reveled neoplastic tumors in two different organs, allowing for radical resection at the same surgical procedure. (author)

  19. Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.

    Science.gov (United States)

    Kanth, Priyanka; Bronner, Mary P; Boucher, Kenneth M; Burt, Randall W; Neklason, Deborah W; Hagedorn, Curt H; Delker, Don A

    2016-06-01

    Sessile serrated colon adenoma/polyps (SSA/P) are found during routine screening colonoscopy and may account for 20% to 30% of colon cancers. However, differentiating SSA/Ps from hyperplastic polyps (HP) with little risk of cancer is challenging and complementary molecular markers are needed. In addition, the molecular mechanisms of colon cancer development from SSA/Ps are poorly understood. RNA sequencing (RNA-Seq) was performed on 21 SSA/Ps, 10 HPs, 10 adenomas, 21 uninvolved colon, and 20 control colon specimens. Differential expression and leave-one-out cross-validation methods were used to define a unique gene signature of SSA/Ps. Our SSA/P gene signature was evaluated in colon cancer RNA-Seq data from The Cancer Genome Atlas (TCGA) to identify a subtype of colon cancers that may develop from SSA/Ps. A total of 1,422 differentially expressed genes were found in SSA/Ps relative to controls. Serrated polyposis syndrome (n = 12) and sporadic SSA/Ps (n = 9) exhibited almost complete (96%) gene overlap. A 51-gene panel in SSA/P showed similar expression in a subset of TCGA colon cancers with high microsatellite instability. A smaller 7-gene panel showed high sensitivity and specificity in identifying BRAF-mutant, CpG island methylator phenotype high, and MLH1-silenced colon cancers. We describe a unique gene signature in SSA/Ps that identifies a subset of colon cancers likely to develop through the serrated pathway. These gene panels may be utilized for improved differentiation of SSA/Ps from HPs and provide insights into novel molecular pathways altered in colon cancer arising from the serrated pathway. Cancer Prev Res; 9(6); 456-65. ©2016 AACR. PMID:27026680

  20. Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation

    Science.gov (United States)

    Methylselenol has been hypothesized to be a critical selenium (Se) metabolite for anticancer activity in vivo. To determine differential chemopreventive effects of methylselenol on colon cancer cells versus colon noncancerous cells, colon-cancer-derived HCT-116 cells and noncancerous colonic NCM460 ...

  1. Intramural ganglia in diverticular disease of the colon

    Science.gov (United States)

    Macbeth, W. A. A. G.; Hawthorne, J. H. R.

    1965-01-01

    Intramural plexuses were studied in 30 colons, and a plethora of ganglionic tissue was observed in specimens with diverticula when compared with a control series. This alteration in the ganglionic pattern is considered real rather than apparent; the changes are confined to the region of the colon where muscular hypertrophy is present. Images PMID:14247702

  2. Case report: Stercoral sigmoid colonic perforation with fecal peritonitis

    International Nuclear Information System (INIS)

    Chronic constipation can lead to fecal impaction. It can also rarely lead to catastrophic complications like perforation, colonic obstruction, and fecal peritonitis. We report a rare case of stercoral sigmoid colonic perforation with fecal peritonitis and pneumoperitoneum, which was diagnosed on preoperative CT scan

  3. Cigarette smoking and genetic alterations in sporadic colon carcinomas

    NARCIS (Netherlands)

    Diergaarde, B.; Vrieling, A.; Kraats, van A.A.; Muijen, van G.N.P.; Kok, F.J.; Kampman, E.

    2003-01-01

    Cigarette smoking has been inconsistently associated with colon cancer risk. To evaluate the hypothesis that smoking is primarily linked to a specific colon tumor subgroup(s), we assessed associations between smoking and the occurrence of mutations in the APC, K-ras and p53 genes, p53 overexpression

  4. Bacterial colonization of psoriasis plaques. Is it relevant?

    Directory of Open Access Journals (Sweden)

    Eva Marcus

    2011-08-01

    Full Text Available Bacterial colonization was investigated retrospectively in patients with plaque psoriasis (n=98 inpatient treatments, n=73 patients. At least one pathogen was found in 46% of all cases. Staphylococcus aureus was the most frequent bacterium. Bacterial colonization of psoriasis plaques could be relevant in individual cases.

  5. Colonic stricture secondary to torsion of an ovarian cyst

    International Nuclear Information System (INIS)

    Intestinal obstruction in the newborn is a potentially life-threatening complication. The most common causes are meconium plug, meconium ileus, intestinal atresia, intestinal malrotation, and Hirschprung's disease. We present an unusual case of intestinal obstruction caused by torsion of an ovarian cyst. The left fimbria and ovary swirled around the sigmoid colon, causing colonic stricture. (orig.)

  6. Colonic stricture secondary to torsion of an ovarian cyst

    Energy Technology Data Exchange (ETDEWEB)

    Karmazyn, Boaz; Ziv, Nitza; Horev, Gadi [Department of Diagnostic Radiology, Schneider Children' s Medical Center of Israel, Petah Tiqva (Israel); Steinberg, Ran; Zer, Michael [Pediatric Surgery, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (Israel)

    2002-01-01

    Intestinal obstruction in the newborn is a potentially life-threatening complication. The most common causes are meconium plug, meconium ileus, intestinal atresia, intestinal malrotation, and Hirschprung's disease. We present an unusual case of intestinal obstruction caused by torsion of an ovarian cyst. The left fimbria and ovary swirled around the sigmoid colon, causing colonic stricture. (orig.)

  7. Role of phytochemicals in colon cancer prevention. A nutrigenomics approach

    NARCIS (Netherlands)

    Erk, van M.J.

    2004-01-01

    Specific food compounds, especially from fruits and vegetables, may protect against development of colon cancer. In this thesis effects and mechanisms of various phytochemicals in relation to colon cancer prevention were studied through application of large-scale gene expression profiling. Expressio

  8. Intestinal health functions of colonic microbial metabolites: A review

    NARCIS (Netherlands)

    Havenaar, R.

    2011-01-01

    This review tries to find a scientific answer on the following two questions: (1) to what extent do we understand the specific role of colonic microbial metabolites, especially short-chain fatty acids (SCFA), in maintaining the health status and prevention of diseases of the colon and the host; (2)

  9. Colonic Fermentation: A Neglected Topic in Human Physiology Education

    Science.gov (United States)

    Valeur, Jorgen; Berstad, Arnold

    2010-01-01

    Human physiology textbooks tend to limit their discussion of colonic functions to those of absorbing water and electrolytes and storing waste material. However, the colon is a highly active metabolic organ, containing an exceedingly complex society of microbes. By means of fermentation, gastrointestinal microbes break down nutrients that cannot be…

  10. Protozoa and their bacterial prey colonize sterile soil fast

    DEFF Research Database (Denmark)

    Altenburger, Andreas; Ekelund, Flemming; Jacobsen, Carsten Suhr

    2010-01-01

    We know little about the ability of protozoa to colonize soils, including their successional patterns. To elucidate this issue, we investigated in which order different protozoan morpho-types colonize sterile soil. We used sterilized soils with different carbon content, and exposed them...

  11. Stercoral perforation of the colon: case report and literature review

    Directory of Open Access Journals (Sweden)

    José Francisco Camacho Aguilera

    2015-03-01

    Full Text Available INTRODUCTION Colon perforation has several causes, including stercoral perforation of the colon, which was first described in 1894. Currently, reported cases are fewer than 100. CASE REPORT Male patient of 67 years old, treated at Huichapan General Hospital, Hidalgo, Mexico, with abdominal pain, bloating and no bowel movements. He referred being constipated for the last ten years. Imaging revealed an extremely dilated sigmoid colon with fecal matter as well as free gas in the peritoneal cavity. The suspicion of stercoral colonic perforation is established. Exploratory laparotomy was performed immediately, finding a perforation and a hard scybalum protruding in the ascending colon. Colectomy, ileostomy and Hartmann´s pouch are performed. After surgery, the condition of the patient worsened and progressed to septic shock and respiratory failure. The patient died four hours after surgery, with the diagnosis of organ failure due to sepsis. LITERATURE REVIEW Stercoral perforation accounts for 3.2% of all colon perforations and is caused by a rupture of the intestinal wall through direct pressure of a fecaloma on the colon. It occurs especially in patients older than 70 years with severe chronic constipation, weakened and/or are hospitalized with multiple medications and immobilized. CONCLUSIONS Stercoral perforation of the colon is a rare cause of bowel perforation, which should be suspected in patients with a history of chronic constipation, acute abdominal pain, bloating and sepsis, in order to intervene in a timely fashion.

  12. Long-term organ culture of adult rat colon

    DEFF Research Database (Denmark)

    1978-01-01

    Colon explants from adult rats were maintained in culture for over 3 months in our laboratories with good epithelial preservation and cellular differentiation. The light and transmission electron microscopic features of rat colon mucosa during the culture period are described. In all the explants...

  13. Prolapse of submucous lipoma of the sigmoid colon

    DEFF Research Database (Denmark)

    Wilhelmsen, Michael; Mynster, Tommie

    2012-01-01

    Lipomas of the colon are rare and usually presenting in the later ages of life. This case describes and discusses the symptoms and signs of lipomas, recommendations and rationale for treatment.......Lipomas of the colon are rare and usually presenting in the later ages of life. This case describes and discusses the symptoms and signs of lipomas, recommendations and rationale for treatment....

  14. Histochemical and radioautographic studies of normal human fetal colon

    International Nuclear Information System (INIS)

    Twenty fetal and infant colons ranging from 10 weeks in utero to 20 months postpartum, and 12 adult human colons were examined using histochemical techniques in conjunction with in vitro radioautography using Na235SO4 as a sulfomucin precursor. Only the sulfated components of mucus in fetal goblet cells was found to differ significantly from adult colonic mucins. In the fetus sulfomucin staining was much weaker than in the adult, and was more intense in the left colon which is the reverse of the adult pattern. Sulfomucin was concentrated in the crypts throughout the fetal colon whereas in the adult right colon it predominated in the surface cells. As in the adult, saponification liberated carboxyl groups, possibly belonging to sialic acid, and vicinal hydroxyl groups from fetal mucins suggesting that this procedure hydrolyses an ester linkage between these 2 reactive groups. During the middle trimester of fetal life the colon possesses villi whose constituent cells display alkaline phosphatase in their surface coat. These and other morphological and histochemical similarities to fetal small intestine suggest that the fetal colon may have a limited capacity to absorb materials contained within swallowed amniotic fluid during this period. (orig.)

  15. Short-term outcomes following laparoscopic resection for colon cancer.

    LENUS (Irish Health Repository)

    Kavanagh, Dara O

    2011-03-01

    Laparoscopic resection for colon cancer has been proven to have a similar oncological efficacy compared to open resection. Despite this, it is performed by a minority of colorectal surgeons. The aim of our study was to evaluate the short-term clinical, oncological and survival outcomes in all patients undergoing laparoscopic resection for colon cancer.

  16. Benign colonic neoplasm at the site of ureterosigmoidostomy

    DEFF Research Database (Denmark)

    Qvist, N; Kronborg, O; Hage, E;

    1986-01-01

    A benign colonic polyp with epithelial dysplasia developed in a young male at the site of ureteral implantation in the sigmoid colon following ureterosigmoidostomy for urinary incontinence. Patients with ureterosigmoidostomy represent a high-risk cancer group, and a review of the literature sugge...

  17. The treatment of locally advanced colon cancer

    International Nuclear Information System (INIS)

    Purpose: The results of therapy for 103 patients with locally advanced colon cancer who received radiotherapy were analyzed to determine the outcome and tolerance of therapy. Methods and Materials: Between 1974 and 1994, 103 patients received radiotherapy and maximal resection of locally advanced colon cancers. Following resection, 50 patients had no residual disease, 18 patients had microscopic residual disease, and 35 patients had gross residual disease. External beam radiotherapy was initiated 1 to 4 months following resection except in two patients who received preoperative radiotherapy. Treatment was delivered to the tumor bed and adjacent lymph nodes using 4 to 18 MV X-rays with doses ranging from 16.2 to 60 Gy. Intraoperative electron radiotherapy (IOERT) was also administered to 11 of the patients with doses ranging from 10 to 20 Gy. Chemotherapy was administered to 77 patients. Follow-up in survivors ranged from 0.5 to 17 years (median: 5.8 years). Results: The 5-year actuarial local failure rate was 10% for patients with no residual disease, 54% for patients with microscopic residual disease, and 79% for patients with gross residual disease (p < 0.0001). For patients with residual disease, local failure occurred in 11% of patients receiving IOERT compared with 82% of patients receiving only external beam therapy (p 0.02). The 5-year actuarial survival rate was 66% for patients with no residual disease, 47% for patients with microscopic residual disease, and 23% for patients with gross residual disease (p = 0.0009). The 5-year survival rate in patients with residual disease was 76% for patients receiving IOERT and 26% for patients receiving external beam therapy alone (p = 0.04). Conclusions: Patients with locally advanced colon cancer who have had a complete resection have a high probability of local control after external beam irradiation ± 5 fluorouracil (5FU)-based systemic therapy. The toxicity of therapy can be minimized with attention to treatment

  18. Investigation of correlation between colonic cancer related anemia and characteristics of clinical pathology

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Objective To investigate the correlation between colonic cancer-related anemia and the pathologic features of colonic cancer.Methods The relationship between colonic cancer-related anemia and the pathologic features of colonic cancer was analyzed in a statistical method.Results There was no statistical significance between the histopathological type and incidence of colonic cancer-related anemia(P>0.05).There was statistical significance between the general classification of colonic cancer

  19. Oxalobacter formigenes Colonization and Oxalate Dynamics in a Mouse Model.

    Science.gov (United States)

    Li, Xingsheng; Ellis, Melissa L; Knight, John

    2015-08-01

    Animal and human studies have provided compelling evidence that colonization of the intestine with Oxalobacter formigenes reduces urinary oxalate excretion and lowers the risk of forming calcium oxalate kidney stones. The mechanism providing protection appears to be related to the unique ability of O. formigenes to rely on oxalate as a major source of carbon and energy for growth. However, much is not known about the factors that influence colonization and host-bacterium interactions. We have colonized mice with O. formigenes OxCC13 and systematically investigated the impacts of diets with different levels of calcium and oxalate on O. formigenes intestinal densities and urinary and intestinal oxalate levels. Measurement of intestinal oxalate levels in mice colonized or not colonized with O. formigenes demonstrated the highly efficient degradation of soluble oxalate by O. formigenes relative to other microbiota. The ratio of calcium to oxalate in diets was important in determining colonization densities and conditions where urinary oxalate and fecal oxalate excretion were modified, and the results were consistent with those from studies we have performed with colonized and noncolonized humans. The use of low-oxalate purified diets showed that 80% of animals retained O. formigenes colonization after a 1-week dietary oxalate deprivation. Animals not colonized with O. formigenes excreted two times more oxalate in feces than they had ingested. This nondietary source of oxalate may play an important role in the survival of O. formigenes during periods of dietary oxalate deprivation. These studies suggest that the mouse will be a useful model to further characterize interactions between O. formigenes and the host and factors that impact colonization. PMID:25979889

  20. Salmonella induces prominent gene expression in the rat colon

    Directory of Open Access Journals (Sweden)

    Roosing Susanne

    2007-09-01

    Full Text Available Abstract Background Salmonella enteritidis is suggested to translocate in the small intestine. In vivo it induces gene expression changes in the ileal mucosa and Peyer's patches. Stimulation of Salmonella translocation by dietary prebiotics fermented in colon suggests involvement of the colon as well. However, effects of Salmonella on colonic gene expression in vivo are largely unknown. We aimed to characterize time dependent Salmonella-induced changes of colonic mucosal gene expression in rats using whole genome microarrays. For this, rats were orally infected with Salmonella enteritidis to mimic a foodborne infection and colonic gene expression was determined at days 1, 3 and 6 post-infection (n = 8 rats per time-point. As fructo-oligosaccharides (FOS affect colonic physiology, we analyzed colonic mucosal gene expression of FOS-fed versus cellulose-fed rats infected with Salmonella in a separate experiment. Colonic mucosal samples were isolated at day 2 post-infection. Results Salmonella affected transport (e.g. Chloride channel calcium activated 6, H+/K+ transporting Atp-ase, antimicrobial defense (e.g. Lipopolysaccharide binding protein, Defensin 5 and phospholipase A2, inflammation (e.g. calprotectin, oxidative stress related genes (e.g. Dual oxidase 2 and Glutathione peroxidase 2 and Proteolysis (e.g. Ubiquitin D and Proteosome subunit beta type 9. Furthermore, Salmonella translocation increased serum IFNγ and many interferon-related genes in colonic mucosa. The gene most strongly induced by Salmonella infection was Pancreatitis Associated Protein (Pap, showing >100-fold induction at day 6 after oral infection. Results were confirmed by Q-PCR in individual rats. Stimulation of Salmonella translocation by dietary FOS was accompanied by enhancement of the Salmonella-induced mucosal processes, not by induction of other processes. Conclusion We conclude that the colon is a target tissue for Salmonella, considering the abundant changes in

  1. NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP).

    Science.gov (United States)

    Shelby, Michael D

    2006-11-01

    The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an updated evaluation of the potential for DEHP to cause adverse effects on reproduction and development in humans. The first CERHR expert panel evaluation of DEHP was completed in 2000 by the Phthalates Expert Panel. CERHR selected DEHP for an updated evaluation because of: (1) widespread human exposure, (2) public and government interest in adverse health effects, (3) recently available human exposure studies, and (4) the large number of relevant toxicity papers published since the earlier evaluation. DEHP (CAS RN: 117-81-7) is a high production volume chemical used as a plasticizer of polyvinyl chloride in the manufacture of a wide variety of consumer goods, such as building products, car products, clothing, food packaging, children's products (but not in toys intended for mouthing), and in medical devices made of polyvinyl chloride. The public can be exposed to DEHP by ingesting food, drink or dust that has been in contact with DEHP-containing materials, by inhaling contaminated air or dust, or by undergoing a medical procedure that uses polyvinyl chloride medical tubing or storage bags. It is estimated that the general population of the United States is exposed to DEHP levels ranging from 1 to 30 microg/kg bw/day (micrograms per kilogram body weight per day). The results of this DEHP update evaluation are published in an NTP-CERHR monograph that includes: (1) the NTP Brief, (2) the Expert Panel Update on the Reproductive and Developmental Toxicity of DEHP, and (3) public comments on the expert panel report. The NTP reached the following conclusions on the possible effects of exposure to DEHP on human development and reproduction. Note that the possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and serious concern. There is serious concern that certain intensive medical treatments of

  2. A child with colo-colonic intussusception due to a large colonic polyp: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Toshiaki Takahashi

    2014-01-01

    Full Text Available Colo-colonic intussusception (CI due to a colonic polyp is a rarely reported cause of intestinal obstruction in school-aged children. Hydrostatic reduction (HR and endoscopic polypectomy are minimally invasive and technically feasible for treating CI. We report a case of CI and review the literature, focusing on the diagnosis and treatment.

  3. Red meat and colon cancer : dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium

    NARCIS (Netherlands)

    Sesink, ALA; Termont, DSML; Kleibeuker, JH; Van der Meer, R

    2000-01-01

    High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role fbr fat,

  4. NH4+ secretion in the avian colon. An actively regulated barrier to ammonium permeation of the colon mucosa

    DEFF Research Database (Denmark)

    Holtug, K.; Laverty, G.; Arnason, S.S.;

    2009-01-01

    Experiments were designed to characterize an active, electrogenic transport of NH(4)(+) ions across the colonic epithelium of the domestic fowl (Gallus gallus). Colonic segments were isolated and stripped of underlying muscle. The mucosal epithelia were mounted in Ussing chambers and voltage-clam...

  5. Ultraflex precision colonic stent placement as a bridge to surgery in patients with malignant colon obstruction

    DEFF Research Database (Denmark)

    Fregonese, D.; Naspetti, R.; Ferrer, S.;

    2008-01-01

    colorectal SEMS may offer several advantages, but available evidence on the utility of this SEMS type remains highly limited. Objective: Our purpose was to evaluate the effectiveness and safety as a bridge to surgery of a nitinol SEMS designed for colorectal use. Design: Prospective and retrospective......Background: Emergency surgery for malignant colon obstruction entails relatively high morbidity and mortality rates and typically necessitates a 2-step resection. These problems might be potentially mitigated by placement of a self-expanding metal stent (SEMS) as a bridge to surgery. A nitinol...... success in alleviating colonic obstructive symptoms, and bridging to elective surgery. Results: Technical success was achieved in 97% of patients with a 95% CI of 85% to 100% and clinical success in 81% (95% CI, 64%-92%). Elective surgery was performed in 94% (95% CI, 81%-99%) of patients at a median of...

  6. Colonic cell proliferation in normal mucosa of patients with colon cancer

    International Nuclear Information System (INIS)

    Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), 3H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns (1) with a high concentration in the bottom fifth of the crypt and (2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt. (orig.)

  7. Experimental evaluation of clinical colon anastomotic leakage

    DEFF Research Database (Denmark)

    Pommergaard, Hans-Christian

    2014-01-01

    , ischemia and insufficient surgical technique have been suggested to play a central role. Animal models are valuable means to evaluate pathophysiological mechanisms and may be used to test preventive measures aiming at reducing the risk of anastomotic leakage, such as external anastomotic coating. The aim...... leakage. STUDY 1: This study is a systematic review using the databases MEDLINE and Rex. MEDLINE was searched up to October 2010 to identify studies on experimental animal models of clinical colon anastomotic leakage. From the Rex database, textbooks on surgical aspects as well as gastrointestinal...... physiology and anatomy of experimental animals were identified. The results indicated that the mouse and the pig are the best suited animals to evaluate clinical anastomotic leakage. However, the pig model is less validated and more costly to use compared with the mouse. Most frequently, rats are used as...

  8. Colonic gallstone ileus: the rolling stones.

    Science.gov (United States)

    Heaney, Roisin Mary

    2014-01-01

    Gallstone ileus is a rare complication of cholelithiasis accounting for 1-4% of cases of intestinal obstruction with a predominance in the elderly population. Unfortunately, it has an insipid presentation and is associated with significant rates of morbidity and mortality. Controversy arises over the management of gallstone ileus, and while surgery remains the mainstay of treatment, the main point of contention surrounds the extent of surgery. We describe the case of an 85-year-old woman who presented with symptoms and signs of large bowel obstruction. Radiological evaluation revealed a 5 cm×3.5 cm gallstone impacted in the sigmoid colon. A laparoscopic-assisted enterolithotomy alone relieved the obstruction with minimal surgical insult and allowed for a swift and uneventful recovery. Our case emphasises the need for a high index of suspicion for the condition as well as highlighting the advantages of the use of laparoscopic surgery in an emergency setting. PMID:25323275

  9. Clinical imaging of the colon and rectum

    International Nuclear Information System (INIS)

    Clinical imaging of the colon and rectum is the first volume of a new series of practical reference works that enables radiologists to effectively utilize today's rapidly evolving imaging technologies in the diagnosis and management of gastrointestinal disorders. Organized in a disease-oriented format, each volume of the series focuses on specific gastrointestinal organs, offering concrete guidelines for performing and interpreting imaging studies of commonly encountered disorders. For each disease process, pathologic findings obtained using various imaging modalities are clearly described; illustrated by high-quality radiographs and scans; and correlated with the clinical features and basic pathology of the disease. The significance of these detected abnormalities is considered in detail, with emphasis on their importance in diagnosis, prognosis, and treatment planning

  10. Detection of colon cancer by terahertz techniques

    Science.gov (United States)

    Wahaia, Faustino; Valusis, Gintaras; Bernardo, Luis M.; Almeida, Abílio; Moreira, Joaquim A.; Lopes, Patricia C.; Macutkevic, Jan; Kasalynas, Irmantas; Seliuta, Dalius; Adomavicius, Ramunas; Henrique, Rui; Lopes, Machado

    2011-12-01

    Human normal and cancer affected samples of colon tissue have been measured using transmission time-domain terahertz spectroscopy and continuous wave terahertz imaging. We show that it is possible to distinguish between normal and cancerous regions in the samples when they are fixed in formalin or embedded in paraffin. The still noticeable contrast in the dried paraffin-embedded tissues could indicate that there are additional contrast-contributing factors other than water, which is the main goal of the present work. Plots of the refractive index of normal and cancer affected tissues as well as 2-D transmission THz images are shown. Experimental results are presented and the conditions for discrimination between normal and affected formalin-fixed and paraffin-embedded tissue are discussed.

  11. Ectopic Varices in Colonic Stoma: MDCT Findings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jae Woong; Lee, Chang Hee; Kim, Kyeong Ah; Park, Cheol Min; Kim, Jin Yong [Guro Hospital of Korea University, Seoul (Korea, Republic of)

    2006-12-15

    We describe the 2D reformatted and 3D volume rendered images by MDCT in a patient with an episode of acute bleeding from the colonic stoma. This case indicates that the 2D reformatted and 3D volume rendered images are useful to detect this rare complication of portal hypertension, and they help to tailor adequate treatment for the patients with bleeding from stomal varices. Ectopic varices are an uncommon cause of gastrointestinal hemorrhage, but they account for up to 5% of all variceal bleedings (1). Bleeding from stomal varices has been reported in up to 20% of the patients suffering with chronic liver failure with permanent stoma (2). However, the diagnosis of stomal varices is difficult because bleeding from stoma may also be associated with lower gastrointestinal bleeding. To the best of our knowledge, the 2D reformatted and 3D volume rendered images by MDCT for visualization of ectopic stomal varices have not been previously reported in the medical literature.

  12. Ectopic Varices in Colonic Stoma: MDCT Findings

    International Nuclear Information System (INIS)

    We describe the 2D reformatted and 3D volume rendered images by MDCT in a patient with an episode of acute bleeding from the colonic stoma. This case indicates that the 2D reformatted and 3D volume rendered images are useful to detect this rare complication of portal hypertension, and they help to tailor adequate treatment for the patients with bleeding from stomal varices. Ectopic varices are an uncommon cause of gastrointestinal hemorrhage, but they account for up to 5% of all variceal bleedings (1). Bleeding from stomal varices has been reported in up to 20% of the patients suffering with chronic liver failure with permanent stoma (2). However, the diagnosis of stomal varices is difficult because bleeding from stoma may also be associated with lower gastrointestinal bleeding. To the best of our knowledge, the 2D reformatted and 3D volume rendered images by MDCT for visualization of ectopic stomal varices have not been previously reported in the medical literature

  13. Bacteria,inflammation,and colon cancer

    Institute of Scientific and Technical Information of China (English)

    Liying Yang; Zhiheng Pei

    2006-01-01

    Our relationship with the colonic bacterial flora has long been viewed as benign,but recent studies suggest that this symbiosis has risks as well as benefits.This relationship requires that the host not only provide a supportive environment for the symbiotic bacteria,but also actively maintain intact mechanisms for properly managing the physiologic stresses that are closely associated with the symbiont's essential survival functions.Failure to do so breaches the hostsymbiont contract,and can result in serious effects on the health of the host.Recent investigations that employ several knockout mouse models reveal the consequences of genetic deficiency in the host regarding these mechanisms,and the latent,pro-inflammatory,tumorigenic nature of normal bacterial flora.Further study of the interactions between normal bacterial flora and hosts could shed light on the etiologies and pathogenesis of inflammatory diseases and related cancers,with implications for human health.

  14. Nasopharyngeal carcinoma with metastases to colon

    Directory of Open Access Journals (Sweden)

    Yatiee Swany Lahuri

    2015-07-01

    Full Text Available Squamous cell carcinoma (SCC of the nasopharynx is amongst the most common head and neck cancers. The most common distant metastases are to the bone, liver and lung. Herein, we are reporting a rare case of a 61-year-old man with nasopharyngeal carcinoma (NPC who presented with 3 weeks history of blood streaked sputum, post nasal drip and blocked nose with no history of epistaxis, tinnitus and unilateral hearing loss. Almost 2 years upon completion of his concurrent chemotherapy and radiotherapy, he developed a right hypochondrium mass and underwent colonoscopy which revealed a mass in ascending colon and which was then subsequently resected via right hemicolectomy. Histological analyses from the resected specimen confirmed its nasopharyngeal origin.

  15. Ectopic fascioliasis mimicking a colon tumor

    Institute of Scientific and Technical Information of China (English)

    Ozer Makay; Baris Gurcu; Cemil Caliskan; Deniz Nart; Muge Tuncyurek; Mustafa Korkut

    2007-01-01

    Fasciola hepatica, a leaf shaped trematode that is common in cattle, sheep and goats, is acquired by eating raw water plants like watercress or drinking water infected with the encysted form of the parasite.The varied clinical presentations of fascioliasis still make a high index of suspicion mandatory. Besides having a wide spectrum of hepatobiliary symptoms like obstructive jaundice, cholangitis and liver cirrhosis, the parasitic infection also has extrabiliary manifestations.Until recently, extrahepatic fascioliasis has been reported in the subcutaneous tissue, brain, lungs, epididymis,inguinal lymph nodes, stomach and the cecum. In this report, a strange manifestation of the fasciola infection in a site other than the liver, a colonic fascioliasis, is presented.

  16. Where There's Smoke,There's Colon Cancer

    Institute of Scientific and Technical Information of China (English)

    王红

    2001-01-01

    @@ Besides causing 160,000 deaths annually from lung, mouth, bladder and other cancers, smoking also increases the risk of death from cancer of the colon or rectum,according to results of a large new study from the American Cancer Society.根据美国癌症协会一项大规模的新的研究结果表明,每年因抽烟而死于肺癌、口腔癌、膀胱癌以及其它癌症的人有16万人;除此之外,抽烟还会增加死于结肠癌、直肠癌的可能性.

  17. Na+ uptake into colonic enterocyte membrane vesicles

    International Nuclear Information System (INIS)

    Na+ uptake was studied in colonic enterocyte membrane vesicles prepared from normal and dexamethasone-treated rats. Vesicles from rats treated with dexamethasone demonstrated a fivefold greater 22Na+ uptake compared with vesicles from normal rats. Most of the tracer uptake in membranes derived from treated rats occurred through a conductive, amiloride-blockable pathway located in vesicles with low native K+ permeability and high Cl- permeability. Kinetic analysis of the amiloride inhibition curve revealed the presence of two amiloride-blockable pathways, one with a high affinity accounting for 85% of the uptake, and one with a low affinity accounting for only 12% of the uptake. Only the low-affinity pathway was detected with vesicles from normal rats. The high sensitivity to amiloride, the dependence on dexamethasone pretreatment, and the relative permeabilities to K+ and Cl- indicate that most of the 22Na+ uptake in membranes derived from treated rats is through a Na+-specific channel located in apical membrane vesicles. Preincubation of the isolated cells from dexamethasone-treated rats at 37 degree C in Ca2+-free solutions before homogenization and membrane vesicle purification caused a 5- to 10-fold increase in amiloride-blockable 22Na+ uptake compared with vesicles derived from cells maintained at 0 degree C. The addition of Ca2+, but not of Mg2+, to the incubation solution markedly reduced this temperature-dependent enhancement in 22Na+ uptake. These results suggest that Na+ transport in colonic enterocytes from dexamethasone-treated rats is regulated by a Ca2+-dependent, temperature-sensitive process which causes a sustained change in the apical membrane

  18. Hereditary colon Cancer: Recommendations for prevention

    International Nuclear Information System (INIS)

    Prevention in individuals with hereditary risk of colon cancer, is subject to clinical and molecular facts because their behavior differs to sporadic cancer. Hereditary cancer diseases affecting the colon in particular linked to other locations or that are associated with pre-cancer (polyps, osteoma s, lentigines) phenotypic markers represent a dissimilar to those who present directly in colorectal cancer status or associated conditions. In the first, the presence of previous injury (phenotypes) allows us to identify, while the latter is essential to have other diagnostic pathway (genotypes) .The location of genomic alterations manages to delve into the problem and identify those who will develop disease. The perspective will be different in the general population and those who do not carry mutations in terms suggestions for prevention, both primary and secondary. Not always the mutation is detected and in these high-risk situations, the clinic is sovereign and agrees to keep all members of these events surveillance strict about not being able to characterize those who are carriers of alterations and our condition is different in the proposition of preventive attitudes: set from when control about which organs and often starts, suffer because of accelerated carcinogenesis. The presentation is focused on populations at increased risk of cancer colorectal, regarding the management of the suggestions for primary prevention, secondary prevention while analyzing the early diagnosis of the disease and the suggestion of treatment, compared to the general population management. Primary prevention, including chemo prevention are described. While in secondary prevention is emphasized to management time tracking, optimization diagnostics according to the pathology suspected, the most common therapeutic approaches and findings relating prophylactic surgery

  19. Colon tumor cells grown in NASA Bioreactor

    Science.gov (United States)

    2001-01-01

    These photos compare the results of colon carcinoma cells grown in a NASA Bioreactor flown on the STS-70 Space Shuttle in 1995 flight and ground control experiments. The cells grown in microgravity (left) have aggregated to form masses that are larger and more similar to tissue found in the body than the cells cultured on the ground (right). The principal investigator is Milburn Jessup of the University of Texas M. D. Anderson Cancer Center. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Cell constructs grown in a rotating bioreactor on Earth (left) eventually become too large to stay suspended in the nutrient media. In the microgravity of orbit, the cells stay suspended. Rotation then is needed for gentle stirring to replenish the media around the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). Credit: NASA and University of Texas M. D. Anderson Cancer Center.

  20. Uncommon presentation of actinomycosis mimicking colonic cancer: Colon actinomycosis with invasion of the abdominal wall

    Directory of Open Access Journals (Sweden)

    Ilhan Bali

    2015-04-01

    Full Text Available Actinomycosis is an uncommon chronic suppurative infectious disease that is caused by Actinomycetes organisms, which are gram-positive, microaerophilic, anaerobic bacteria. Herein, we present the case of a 42-year-old female patient who underwent surgical exploration following presentation with abdominal pain and an abdominal mass, initially thought to be a malignancy. Histological examination of the specimen revealed colon actinomycosis. [Arch Clin Exp Surg 2015; 4(2.000: 107-110

  1. Pathogenesis, diagnosis and management of primary melanoma of the colon

    Directory of Open Access Journals (Sweden)

    Imam Ayesha

    2011-02-01

    Full Text Available Abstract Background Melanomas within the alimentary tract are usually metastatic in origin. On the other hand, primary melanomas of the gastrointestinal tract are relatively uncommon. There are several published reports of melanomas occurring in the esophagus, stomach, small bowel, and anorectum. The occurrence of primary melanoma of the colon has, however, only been rarely reported. The optimum modus operandi for the management of primary colonic melanoma remains nebulous due to the limited number of reports in literature. Methods A comprehensive search of Medline, Cochrane and Highwire was performed using the following keywords: 'melanoma', 'malignant melanoma', 'primary melanoma', 'colon', 'gastrointestinal tract', 'alimentary tract', 'digestive tract', and 'large bowel'. All patients with primary melanoma localized to the colon were included in the review. Patients with metastatic melanomas to the gastrointestinal (GI tract and primary melanomas localized to the GI tract in anatomic locations other than colon were excluded. Results There have been only 12 reported cases of primary melanoma of the colon to date. The average age of patients on presentation was 60.4 years without any significant gender predilection. Right colon (33% and cecum (33% were the most common sites for the occurrence of primary colonic melanoma while abdominal pain (58% and weight loss (50% were the most common presenting complaints. Colonoscopy is the most reliable diagnostic investigation and offers the additional advantage of obtaining tissue for diagnosis. S-100 and HMB-45 are highly sensitive and specific for the diagnosis of this malignancy. For primary colonic melanomas that have not metastasized to any distant parts of the body, surgical resection with wide margins appears to be the treatment of choice. Although the management was individualized in every case, most of the authors preferred traditional hemicolectomy as the favored surgical approach

  2. Hypothalamic circuit regulating colonic transit following chronic stress in rats.

    Science.gov (United States)

    Yoshimoto, Sazu; Cerjak, Diana; Babygirija, Reji; Bulbul, Mehmet; Ludwig, Kirk; Takahashi, Toku

    2012-03-01

    Although acute stress accelerates colonic transit, the effect of chronic stress on colonic transit remains unclear. In this study, rats received repeated restraint stress (chronic homotypic stress) or various types of stress (chronic heterotypic stress) for 5 and 7 days, respectively. Vehicle saline, oxytocin (OXT), OXT receptor antagonist or corticotropin-releasing factor (CRF) receptor antagonists were administered by intracerebroventricular (ICV) injection prior to restraint stress for 90 min. Immediately after the stress exposure, the entire colon was removed and the geometric center (GC) of Na51CrO4 (a nonabsorbable radioactive marker; 0.5 μCi) distribution was calculated to measure the transit. Gene expression of OXT and CRF in the paraventricular nucleus (PVN) was evaluated by in situ hybridization. Accelerated colonic transit with the acute stressor was no longer observed following chronic homotypic stress. This restored colonic transit was reversed by ICV injection of an OXT antagonist. In contrast, chronic heterotypic stress significantly accelerated colonic transit, which was attenuated by ICV injection of OXT and by a CRF receptor 1 antagonist. OXT mRNA expression in the PVN was significantly increased following chronic homotypic stress, but not chronic heterotypic stress. However, CRF mRNA expression in the PVN was significantly increased following acute and chronic heterotypic stress, but not chronic homotypic stress. These results indicate that central OXT and CRF play a pivotal role in mediating the colonic dysmotility following chronic stress in rats. PMID:21936687

  3. Paleoenvironmental evidence for first human colonization of the eastern Caribbean

    Science.gov (United States)

    Siegel, Peter E.; Jones, John G.; Pearsall, Deborah M.; Dunning, Nicholas P.; Farrell, Pat; Duncan, Neil A.; Curtis, Jason H.; Singh, Sushant K.

    2015-12-01

    Identifying and dating first human colonization of new places is challenging, especially when group sizes were small and material traces of their occupations were ephemeral. Generating reliable reconstructions of human colonization patterns from intact archaeological sites may be difficult to impossible given post-depositional taphonomic processes and in cases of island and coastal locations the inundation of landscapes resulting from post-Pleistocene sea-level rise. Paleoenvironmental reconstruction is proving to be a more reliable method of identifying small-scale human colonization events than archaeological data alone. We demonstrate the method through a sediment-coring project across the Lesser Antilles and southern Caribbean. Paleoenvironmental data were collected informing on the timing of multiple island-colonization events and land-use histories spanning the full range of human occupations in the Caribbean, from the initial forays into the islands through the arrival and eventual domination of the landscapes and indigenous people by Europeans. In some areas, our data complement archaeological, paleoecological, and historical findings from the Lesser Antilles and in others amplify understanding of colonization history. Here, we highlight data relating to the timing and process of initial colonization in the eastern Caribbean. In particular, paleoenvironmental data from Trinidad, Grenada, Martinique, and Marie-Galante (Guadeloupe) provide a basis for revisiting initial colonization models of the Caribbean. We conclude that archaeological programs addressing human occupations dating to the early to mid-Holocene, especially in dynamic coastal settings, should systematically incorporate paleoenvironmental investigations.

  4. Colonic diverticulosis: evaluation with double contrast barium enema

    International Nuclear Information System (INIS)

    To evaluate the pattern of colonic diverticulosis according to age and sex, and recent trend. The authors retrospectively reviewed 120 cases of colonic diverticulosis in 1,020 patients who had undergone a double contrast barium enema examination between January 1st, 1993, and December 31st, 1995, and analyzed the frequency, size, multiplicity and anatomical site, according to age and sex. Diverticulum size was classified into one of three groups : less than 5mm, 5-10mm, over 10mm in diameter. The overall incidence of colonic diverticulosis was 120 cases among 1,020 patients(11.8%) with an incidence 5.3 times higher in males than in females. Peak incidence was in the fifth decade, with 19 cases (15.8%) among males, and after the sixth decade, with four cases(3.3%) among females. Mean age was 57.7 years. Diverticulum size of 5-10mm in diameter was predominant (2% of cases); average diameter was 5-6mm. The incidence of colonic diverticulosis was 5.1 times more frequent in the right colon (101 cases) than in the left (20 cases). The overall incidence of colonic diverticulosis has continually increased; in addition it has also recently increased slightly in left-sided colon. This is thought to be due to various factors, both congenital and acquired, including longer life with good health care, constipation, irritable bowel syndrome, stress and the tendency of eating patterns to more closely resemble those of the west

  5. Colonic diverticulosis: evaluation with double contrast barium enema

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Jae Kook; Lee, Jong Koo; Yun, Eun Joo; Moon, Hee Jung; Shin, Hyun Ja [Korea Veterans Hospital, Seoul (Korea, Republic of)

    1997-02-01

    To evaluate the pattern of colonic diverticulosis according to age and sex, and recent trend. The authors retrospectively reviewed 120 cases of colonic diverticulosis in 1,020 patients who had undergone a double contrast barium enema examination between January 1st, 1993, and December 31st, 1995, and analyzed the frequency, size, multiplicity and anatomical site, according to age and sex. Diverticulum size was classified into one of three groups : less than 5mm, 5-10mm, over 10mm in diameter. The overall incidence of colonic diverticulosis was 120 cases among 1,020 patients(11.8%) with an incidence 5.3 times higher in males than in females. Peak incidence was in the fifth decade, with 19 cases (15.8%) among males, and after the sixth decade, with four cases(3.3%) among females. Mean age was 57.7 years. Diverticulum size of 5-10mm in diameter was predominant (2% of cases); average diameter was 5-6mm. The incidence of colonic diverticulosis was 5.1 times more frequent in the right colon (101 cases) than in the left (20 cases). The overall incidence of colonic diverticulosis has continually increased; in addition it has also recently increased slightly in left-sided colon. This is thought to be due to various factors, both congenital and acquired, including longer life with good health care, constipation, irritable bowel syndrome, stress and the tendency of eating patterns to more closely resemble those of the west.

  6. Colorectal cancers mimic structural organization of normal colonic crypts.

    Directory of Open Access Journals (Sweden)

    Laura Cernat

    Full Text Available Colonic crypts are stereotypical structures with distinct stem cell, proliferating, and differentiating compartments. Colorectal cancers derive from colonic crypt epithelia but, in contrast, form morphologically disarrayed glands. In this study, we investigated to which extent colorectal cancers phenocopy colonic crypt architecture and thus preserve structural organization of the normal intestinal epithelium. A subset of colon cancers showed crypt-like compartments with high WNT activity and nuclear β-Catenin at the leading tumor edge, adjacent proliferation, and enhanced Cytokeratin 20 expression in most differentiated tumor epithelia of the tumor center. This architecture strongly depended on growth conditions, and was fully reproducible in mouse xenografts of cultured and primary colon cancer cells. Full crypt-like organization was associated with low tumor grade and was an independent prognostic marker of better survival in a collection of 221 colorectal cancers. Our findings suggest that full activation of preserved intestinal morphogenetic programs in colon cancer requires in vivo growth environments. Furthermore, crypt-like architecture was linked with less aggressive tumor biology, and may be useful to improve current colon cancer grading schemes.

  7. Frequency of Thyroid Nodules among Patients with Colonic Polyps

    Directory of Open Access Journals (Sweden)

    Cevdet Duran

    2012-01-01

    Full Text Available Aim. Colonic polyps and thyroid nodules are common diseases and their frequency increases with age. In the literature, there is no study investigating the coexistence of colonic polyps and thyroid nodules. Therefore, this study was designed to investigate thyroid nodule prevalence in patients with colonic polyps. Material and Methods. Sixty-six patients with colonic polyps and 146 patients without colonic polyps enrolled into the study. Age and sex matched control group was composed from patients without colonic polyps. Colonoscopic examinations, thyroid ultrasonographies were performed in all patients, and TSH were measured. Results. Male/female ratio in polyp and control groups were 40/26 versus 68/78, respectively (P=0.058. Mean ages were similar in both groups (53.3±11.4 versus, 51.8±11.4, P=0.373. Thyroid nodule was detected in 44 (66.7% patients with polyps and in 61 (41.8% controls (P=0.001. Patients with adenomatous polyps had 5 or more thyroid nodules compared to patients with hyperplastic polyps (P=0.03. Thyroid nodules were more prevalent among patients aged 50 or older compared to 50 years or less (P=0.023. Conclusion. Thyroid nodules were detected more common in patients with colonic polyps. Further studies are needed to clarify this coexistence.

  8. The social structure of microbial community involved in colonization resistance.

    Science.gov (United States)

    He, Xuesong; McLean, Jeffrey S; Guo, Lihong; Lux, Renate; Shi, Wenyuan

    2014-03-01

    It is well established that host-associated microbial communities can interfere with the colonization and establishment of microbes of foreign origins, a phenomenon often referred to as bacterial interference or colonization resistance. However, due to the complexity of the indigenous microbiota, it has been extremely difficult to elucidate the community colonization resistance mechanisms and identify the bacterial species involved. In a recent study, we have established an in vitro mice oral microbial community (O-mix) and demonstrated its colonization resistance against an Escherichia coli strain of mice gut origin. In this study, we further analyzed the community structure of the O-mix by using a dilution/regrowth approach and identified the bacterial species involved in colonization resistance against E. coli. Our results revealed that, within the O-mix there were three different types of bacterial species forming unique social structure. They act as 'Sensor', 'Mediator' and 'Killer', respectively, and have coordinated roles in initiating the antagonistic action and preventing the integration of E. coli. The functional role of each identified bacterial species was further confirmed by E. coli-specific responsiveness of the synthetic communities composed of different combination of the identified players. The study reveals for the first time the sophisticated structural and functional organization of a colonization resistance pathway within a microbial community. Furthermore, our results emphasize the importance of 'Facilitation' or positive interactions in the development of community-level functions, such as colonization resistance. PMID:24088624

  9. Scintigraphic measurement of colonic transit in patients with idiopathic constipation

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, K. H.; Kim, C. K. [College of Medicine, Wonkwang Univ., Iksan (Korea, Republic of)

    1999-07-01

    To evaluate usefulness of scintigraphic measurement of total and regional colonic transit in patients with idiopathic constipation. 25 patients who were complained chronic constipation underwent scintigraphic measurement of the total and regional colon transit. Of them 10 patients were diagnosed as idiopathic constipation, none of whom had evidence of abnormal function of the pelvic floor. Ten healthy volunteers were also studied. 67 Gallium-labelled Amberlite resin particles were ingested in a coated capsule with methacrylate that dispersed in the ileocecal region. Images were obtained using a gamma camera at regular intervals for the 2, 4, 8, 24, and 48 hours after the initial counting of the radioactivity in the cecum. We determined the geometric center in four regions of interest in the colon (ascending, transverse, descending, and rectosigmoid). Ten patients with colonic inertia showed significant retention of solid residue in the ascending and transverse colon over a 48-hour period. The median values for the healthy subjects at 2, 4, 8, and 24, and 48 hours were 1.44{+-}0.2 (midway through ascending), 1.71{+-}0.45 (midway through transverse), 2.64{+-}0.95 (midway through descending), 3.94{+-}0.89 (midway through rectosigmoid), and 4.52{+-}0.76 (midway through the stool compartment). On the contrary, the values of ten patients with colonic inertia were 1.0{+-}0.0 (midway through ascending), 1.0{+-}0.0 (midway through ascending). 1.02 {+-}0.06 (midway through ascending), 1.70{+-}0.36 (midway through transverse), and 2.33{+-}0.31(midway through descending) at the same time (p<0.001). In patients with idiopathic constipation is characterized by exaggerated reservoir factions of the ascending and transverse colons. Scintigraphy using 67 Gallium-labelled pellets seems to be a useful tool to demonstrate the delayed colonic transit in patients with colonic inertia.

  10. Microvascular circulation of the ascending colon in horses

    International Nuclear Information System (INIS)

    Microvascular circulation of the ascending colon in healthy horses was studied using microangiography, light microscopy, and scanning electron microscopy. The pelvic flexure with 30 cm of ventral and dorsal colon attached was removed from 14 adult horses immediately after horses were euthanatized. The lumen was flushed with warm water, and this section of the ascending colon was placed in a 37-C bath of isotonic NaCl. In sections from 8 horses, colic vessels were perfused with a radio-opaque medium for microangiography. After angiographic evaluation, tissue sections were prepared for light microscopic observation, using standard histologic methods. In sections from 6 horses, injection replicas were made by perfusing the vessels with 2 types of plastics. The results of microangiography, light microscopy, and scanning electron microscopy of vascular replicas were correlated, providing acomprehensive documentation of the microvasculature of the ascending colon at the pelvic flexure. Arteries branched from mesenteric colic vessels approximately every 2 cm toward the colonic tissue. Immediately after branching, arterial vessels formed an anastomotic plexus, the colonic rete. However, each branch from the colic vessel eventually continued into the colonic tissue. A second set of vessels originated from the colonic rete and supplied the mesenteric lymph nodes. Arterial vessels penetrated the tunica muscularis into the sub-mucosa 3 to 4 cm toward the antimesenteric border forming a submucosal vascular network. From the submucosal arterioles, branching took place at right angles to supply the mucosal capillaries. Capillaries surrounded the colonic glands and anastomosed at the luminal surface, forming a superficial luminal honeycomb-appearing vascular plexus. Venules, sparsely distributed, drained the superficial plexus. Arterial venous anastomoses were not observed within the mucosa

  11. Diagnosis and management of colonic injuries following blunt trauma

    Institute of Scientific and Technical Information of China (English)

    Yi-Xiong Zheng; Li Chen; Si-Feng Tao; Ping Song; Shao-Ming Xu

    2007-01-01

    AIM: To retrospectively evaluate the preoperative diagnostic approaches and management of colonic injuries following blunt abdominal trauma.METHODS: A total of 82 patients with colonic injuries caused by blunt trauma between January 1992 and December 2005 were enrolled. Data were collected on clinical presentation, investigations, diagnostic methods,associated injuries, and operative management. Colonic injury-related mortality and abdominal complications were analyzed.RESULTS: Colonic injuries were caused mainly by motor vehicle accidents. Of the 82 patients, 58 (70.3%) had other associated injuries. Laparotomy was performed within 6 h after injury in 69 cases (84.1%), laparoscopy in 3 because of haemodynamic instability. The most commonly injured site was located in the transverse colon. The mean colon injury scale score was 2.8. The degree of faecal contamination was classified as mild in 18 (22.0%), moderate in 42 (51.2%), severe in 14 (17.1%), and unknown in 8 (9.8%) cases. Sixty-seven patients (81.7%) were treated with primary repair or resection and anastomosis. Faecal stream diversion was performed in 15 cases (18.3%). The overall mortality rate was 6.1%. The incidence of colonic injuryrelated abdominal complications was 20.7%. The only independent predictor of complications was the degree of peritoneal faecal contamination (P = 0.02).CONCLUSION: Colonic injuries following blunt trauma are especially important because of the severity and complexity of associated injuries. A thorough physical examination and a combination of tests can be used to evaluate the indications for laparotomy. One stage management at the time of initial exploration is most often used for colonic injuries.

  12. Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph (FM) for over-the-counter (OTC) dandruff, seborrheic dermatitis, and psoriasis drug products to include the combination of 1.8 percent coal tar solution and 1.5 percent menthol in a shampoo drug product to control dandruff. FDA did not receive any comments or data in response to its previously proposed rule to include this combination. This final rule is part of FDA's ongoing review of OTC drug products.

  13. Myofibroblasts and colonic anastomosis healing in Wistar rats

    OpenAIRE

    Vasiliadou Kalliopi; Hytiroglou Prodromos; Apostolidis Stylianos; Basdanis George; Anthimidis Georgios; Efthimiadis Christoforos; Kosmidis Christophoros; Prousalidis John; Fahantidis Epameinondas

    2011-01-01

    Abstract Background The myofibroblasts play a central role in wound healing throughout the body. The process of wound healing in the colon was evaluated with emphasis on the role of myofibroblasts. Methods One hundred male Wistar rats weighing 274 ± 9.1 g (mean age: 3.5 months) were used. A left colonic segment was transected and the colon was re-anastomosed. Animals were randomly divided into two groups. The first group experimental animals (n = 50) were sacrificed on postoperative day 3, wh...

  14. Short colon in two cats and a dog

    International Nuclear Information System (INIS)

    Two cats and 1 dog were referred for evaluation of signs of large-intestinal dysfunction. In each instance, contrast radiography revealed an abnormally short, straight colon, with the cecum located in the left hemi-abdomen. Short colon did not appear to contribute specifically to the active disease processes found. The anomaly may develop owing to errors in the processes of elongation and rotation of the embryo's midgut. The clinical relevance of short colon is unknown, but the disorder may contribute to a history of chronic elimination of soft feces

  15. Studies on mycoflora colonizing raw keratin wastes in arable soil

    Directory of Open Access Journals (Sweden)

    Teresa Korniłłowicz

    2014-08-01

    Full Text Available The present studies showed that feathers placed in soil demonstrated the succesion of physiologically differentiated communities of micromycetes. The first colonizers were sugar fungi. The second phase of feather colonization showed the prevalence of nutritively undeveloped polyphages and "root" celulolytic fungi. The final phase of colonization was dominated by keratinophilic fungi together with microflora that involved the forms known mainly for their strong proteolytic abilities. It was found that both the Chemical structure of substrate and soil properties with its pH determined the qualitative composition of fungal flora.

  16. Assisted Colonization A Question of Focal Units and Recipient Localities

    DEFF Research Database (Denmark)

    Kreyling, Juergen; Bittner, Torsten; Jaeschke, Anja; Jentsch, Anke; Steinbauer, Manuel; Thiel, Daniel; Beierkuhnlein, Carl

    2011-01-01

    Assisted colonization as an adaptation strategy to conserve or restore biodiversity in the face of climate change deservedly evokes controversy. Assisted colonization is perceived by some as a last option for conserving endangered species and by others as a risky and unwise management effort due to...... in coral reefs. For a given conservation or restoration need (e.g. conservation of rare species), we recommend the assisted colonization of pre-adapted ecotypes of the relevant foundation species from climates similar to future expectations for the target site. This approach could lead to climate...

  17. Expression profiling of colon cancer cell lines and colon biopsies: towards a screening system for potential cancer-preventive compounds.

    Science.gov (United States)

    van Erk, M J; Krul, C A M; Caldenhoven, E; Stierum, R H; Peters, W H; Woutersen, R A; van Ommen, B

    2005-10-01

    Interest in mechanisms of colon cancer prevention by food compounds is strong and research in this area is often performed with cultured colon cancer cells. In order to assess utility for screening of potential cancer-preventive (food) compounds, expression profiles of 14 human cell lines derived from colonic tissue were measured using cDNA microarrays with 4000 genes and compared with expression profiles in biopsies of human colon tumours and normal tissue. Differences and similarities in the gene expression profiles of the cell lines were analysed by clustering and principal component analysis (PCA). Cytoskeleton genes and immune response genes are two functional classes of genes that contributed to the differences between the cell lines. A subset of 72 colon cancer-specific genes was identified by comparing expression profiles in human colon biopsies of tumour tissue and normal tissue. A separation of the cell lines based on the tumour stage of the original adenocarcinoma was observed after PCA of expression data of the subset of colon cancer-specific genes in the cell lines. The results of this study may be useful in the ongoing research into mechanisms of cancer prevention by dietary components. PMID:16175049

  18. Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.

    Science.gov (United States)

    Charepalli, Venkata; Reddivari, Lavanya; Radhakrishnan, Sridhar; Vadde, Ramakrishna; Agarwal, Rajesh; Vanamala, Jairam K P

    2015-12-01

    Cancer stem cells (CSCs) are shown to be responsible for initiation and progression of tumors in a variety of cancers. We previously showed that anthocyanin-containing baked purple-fleshed potato (PP) extracts (PA) suppressed early and advanced human colon cancer cell proliferation and induced apoptosis, but their effect on colon CSCs is not known. Considering the evidence of bioactive compounds, such as anthocyanins, against cancers, there is a critical need to study anticancer activity of PP, a global food crop, against colon CSCs. Thus, isolated colon CSCs (positive for CD44, CD133 and ALDH1b1 markers) with functioning p53 and shRNA-attenuated p53 were treated with PA at 5.0 μg/ml. Effects of baked PP (20% wt/wt) against colon CSCs were also tested in vivo in mice with azoxymethane-induced colon tumorigenesis. Effects of PA/PP were compared to positive control sulindac. In vitro, PA suppressed proliferation and elevated apoptosis in a p53-independent manner in colon CSCs. PA, but not sulindac, suppressed levels of Wnt pathway effector β-catenin (a critical regulator of CSC proliferation) and its downstream proteins (c-Myc and cyclin D1) and elevated Bax and cytochrome c, proteins-mediating mitochondrial apoptosis. In vivo, PP reduced the number of crypts containing cells with nuclear β-catenin (an indicator of colon CSCs) via induction of apoptosis and suppressed tumor incidence similar to that of sulindac. Combined, our data suggest that PP may contribute to reduced colon CSCs number and tumor incidence in vivo via suppression of Wnt/β-catenin signaling and elevation of mitochondria-mediated apoptosis. PMID:26383537

  19. Isolated colonic schwannoma in the ascending colon: A case report and literature review of Schwannomas in the large intestine

    International Nuclear Information System (INIS)

    Schwannomas are benign mesenchymal spindle cell tumors arising from the Schwann cells that form the peripheral neural sheath. Several recent studies indicate that although reports of gastrointestinal schwannomas have increased with advanced technological developments in immunohistochemical staining, isolated colonic schwannomas are extremely rare. Moreover, it is known to be somewhat difficult to diagnose colonic schwannoma before surgical operation. In this paper, we report a case of isolated schwannoma that was incidentally discovered in the ascending colon, along with a review of few recent literatures.

  20. Isolated colonic schwannoma in the ascending colon: A case report and literature review of Schwannomas in the large intestine

    Energy Technology Data Exchange (ETDEWEB)

    Nam, In Chul; Lee, Ye Daum; Kim, Seung Ho; Yoon, Jung Hee; Baek, Hye Jin; Lee, Kwang Hwi; Nam, Kyung Han [Haeundae Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)

    2015-05-15

    Schwannomas are benign mesenchymal spindle cell tumors arising from the Schwann cells that form the peripheral neural sheath. Several recent studies indicate that although reports of gastrointestinal schwannomas have increased with advanced technological developments in immunohistochemical staining, isolated colonic schwannomas are extremely rare. Moreover, it is known to be somewhat difficult to diagnose colonic schwannoma before surgical operation. In this paper, we report a case of isolated schwannoma that was incidentally discovered in the ascending colon, along with a review of few recent literatures.

  1. Green vegetables and colon cancer: the mechanism of a protective effect by chlorophyll

    OpenAIRE

    Vogel, de, E.F.

    2006-01-01

    One of the important environmental determinants of the risk of colon cancer is the composition of the diet. Regular consumption of high amounts of red meat increases colon cancer risk. In contrast, consumption of green vegetables decreases the risk of colon cancer. This thesis provides a molecular mechanism of how these two dietary components might modulate colon cancer risk.

  2. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

    NARCIS (Netherlands)

    Ou, J.; Carbonero, F.; Zoetendal, E.G.; Delany, J.P.; Wang, M.; Newton, K.; Gaskins, H.R.; O'Keefe, S.F.

    2013-01-01

    BACKGROUND: Epidemiologic studies have suggested that most cases of sporadic colon cancer can be attributed to diet. The recognition that colonic microbiota have a major influence on colonic health suggests that they might mediate colonic carcinogenesis. OBJECTIVE: To examine the hypothesis that the

  3. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

    DEFF Research Database (Denmark)

    Roager, Henrik Munch; Hansen, Lea Benedicte Skov; Bahl, Martin Iain;

    2016-01-01

    Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transi...

  4. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells

    NARCIS (Netherlands)

    Van Erk, Marjan J; Teuling, Eva; Staal, Yvonne CM; Huybers, Sylvie; Van Bladeren, Peter J; Aarts, Jac MMJG; Van Ommen, Ben

    2004-01-01

    BACKGROUND: Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an a

  5. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells

    NARCIS (Netherlands)

    Erk, van M.J.; Teuling, E.; Staal, Y.C.M.; Huybers, S.; Bladeren, van P.J.; Aarts, J.M.M.J.G.; Ommen, van B.

    2004-01-01

    Background: Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an a

  6. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells

    NARCIS (Netherlands)

    Erk, M.J. van; Teuling, E.; Staal, Y.C.M.; Huybers, S.; Bladeren, P.J. van; Aarts, J.M.M.J.G.; Ommen, B. van

    2004-01-01

    Background. Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an a

  7. Usefulness of virtual colonoscopy in the diagnosis of symptomatic large colonic lipomas

    International Nuclear Information System (INIS)

    Full text: Lipomas of the colon are uncommon tumour of the gastrointestinal tract, but cause diagnostic difficulty when they are symptomatic. We reported two cases of symptomatic, large colonic lipoma. Colonoscopy was incomplete because of the narrowing lumen caused by lipomas. By the help of computed tomography colonography/virtual colonoscopy, colonic lipomas were diagnosed correctly, but also proximal colon was examined

  8. Laparoscopic excision of an ascending colon duplication cyst in an adolescent

    OpenAIRE

    Nolan, Heather R.; Craig Wengler; Charles W. Hartin; Joshua B. Glenn

    2016-01-01

    Colonic intestinal duplications are infrequent and rarely present past early childhood. We present the case of a large, ascending colon duplication in a 17-year-old boy resected using minimally invasive techniques. This appears to be the first reported case of a laparoscopic en-bloc ascending colon duplication resection in an adolescent. The diagnosis and management of colonic duplications are discussed.

  9. Seropositivity for and Intestinal Colonization with Entamoeba histolytica and Entamoeba dispar in Individuals in Northeastern Brazil

    OpenAIRE

    Braga, Lucia L.; Mendonca, Yacy; Paiva, Clece A.; Sales, Andrea; Cavalcante, Andre L. M.; Mann, Barbara J.

    1998-01-01

    In a slum community in northeastern Brazil 20% of a sample population was colonized with Entamoeba histolytica or Entamoeba dispar and 10.6% was colonized with E. histolytica alone. No correlation between seropositivity for anti-GalNAc lectin antibody and colonization was found. These results suggest that colonization does not necessarily produce immunity to reinfection.

  10. Risk Factors for Persistent MRSA Colonization in Children with Multiple Intensive Care Unit Admissions

    OpenAIRE

    Popoola, Victor O; Tamma, Pranita; Reich, Nicholas G.; Perl, Trish M.; Milstone, Aaron

    2013-01-01

    We studied MRSA colonized children with multiple ICU admissions to assess the persistence of MRSA colonization. Our data found that children with more than one year between ICU admissions had a higher MRSA colonization prevalence than the overall ICU population, supporting empiric contact precautions for children with prior MRSA colonization.

  11. Site-specific colonic carcinoma in identical twins.

    OpenAIRE

    Whitehead, S.

    1980-01-01

    The development of identically sited carcinomas of the colon in monozygotic twins is described. Presentation occurred with 2 years of each other. They are discussed in the context of the cancer-family syndrome.

  12. Efficient and reproducible identification of mismatch repair deficient colon cancer

    DEFF Research Database (Denmark)

    Joost, Patrick; Bendahl, Pär-Ola; Halvarsson, Britta;

    2013-01-01

    BACKGROUND: The identification of mismatch-repair (MMR) defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment predictive purposes. Preselection of tumors for MMR analysis can be obtained with predictive models, which need to demonstrate ease of...... and efficiently identifies MMR defective colon cancers with high sensitivity and specificity. The model shows stable performance with low inter-observer variability and favorable performance when compared to other MMR predictive models....... application and favorable reproducibility. METHODS: We validated the MMR index for the identification of prognostically favorable MMR deficient colon cancers and compared performance to 5 other prediction models. In total, 474 colon cancers diagnosed ≥ age 50 were evaluated with correlation between...

  13. Novel diagnostics and therapy of colonic motor disorders.

    Science.gov (United States)

    Dinning, P G; Scott, S M

    2011-12-01

    Colonic motor abnormalities are implicated in several gastrointestinal disorders including constipation, irritable bowel syndrome and functional diarrhoea. Defining the colonic abnormalities is difficult and several novel techniques including, high-resolution fibre optic manometry, wireless motility capsules, ultrasound and magnetic resonance imaging have emerged to help in the diagnosis of these conditions. Coupled with the developing techniques are the novel treatments that look to restore normal colonic motility. These treatments include pharmacological agents (pharmabiotics, serotonin agonist, secretagogues) and medical devices (sacral nerve stimulation, transcutaneous electrical stimulation and biofeedback). This review summarizes the novel techniques used to record and define colonic motor abnormalities and the current status of the emerging treatments used to treat them. PMID:22019567

  14. Potentialities of computed tomography and ultrasonography in colonic cancer

    International Nuclear Information System (INIS)

    Data of examination of 59 patients with colonic cancer were used to consider the potentialities of transabdominal, transrectal ultrasonography and X-ay compound tomography and to assess their value in diagnosing colonic cancer, including its minor forms. Ultrasound and computed tomographic semiotics of colonic cancer and determines a place of the above techniques in the algorithm of radiation and instrumental studies are described. Inclusion of these techniques into the diagnostic algorithm may solve a range of differentially diagnostic problems and allows a preliminary analysis to be made in a tumor lesion according to the International TNM classification. Ultrasonography and X-ray computed tomography should be included into a range of basic methods for diagnosis of colonic cancer

  15. Microchimerism and survival after breast and colon cancer diagnosis

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads

    2012-01-01

    addendum, I report the survival of cases in the original study after being diagnosed with cancer. Despite small numbers, the analysis suggests that microchimerism may be positively associated with survival after breast and maybe colon cancer diagnosis. Despite the findings on colon cancer in our original......Recently, we reported microchimerism to be oppositely associated with maternal breast and colon cancer. In women with a blood test positive for male microchimerism the risk of breast cancer development was reduced to one third, whereas the risk of colon cancer was elevated 4-fold. In this article...... report, I speculate whether microchimerism could have a general beneficial role in cancer, which in some sites may not be evident because an allogeneic maternal immune reaction hastens cancer development....

  16. Feedback - Colon Cancer Conference and Workshop 2010 —

    Science.gov (United States)

    This document contains feedback given by the participants of the Colon Cancer Conference and the Histopathology workshop. The meetings took place in October 2010 at the Jackson Laboratory in Bar Harbor, Maine.

  17. Novel colon targeted drug delivery system using natural polymers

    Directory of Open Access Journals (Sweden)

    Ravi V

    2008-01-01

    Full Text Available A novel colon targeted tablet formulation was developed using pectin as carrier and diltiazem HCl and indomethacin as model drugs. The tablets were coated with inulin followed by shellac and were evaluated for average weight, hardness and coat thickness. In vitro release studies for prepared tablets were carried out for 2 h in pH 1.2 HCl buffer, 3 h in pH 7.4 phosphate buffer and 6 h in simulated colonic fluid. The drug release from the coated systems was monitored using UV/Vis spectroscopy. In vitro studies revealed that the tablets coated with inulin and shellac have limited the drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. The study revealed that polysaccharides as carriers and inulin and shellac as a coating material can be used effectively for colon targeting of both water soluble and insoluble drugs.

  18. Colon cancer associated with radiation colitis, report of a case

    Energy Technology Data Exchange (ETDEWEB)

    Nakashima, Rikiya; Kitagawa, Shinji; Okazaki, Masatoshi; Ikehara, Yasuhito; Tanaka, Shinnosuke; Iwanaga, Shinichi [Fukuoka Univ. (Japan). Hospital; Nakamura, Yuichi [Nakamura Gastroenterology, Fukuoka (Japan)

    2002-07-01

    A 70-year-old female presented with abdominal pain in February 1994. She had undergone barium enema examination at a local hospital, and a stricture was pointed out in the rectosigmoid colon. She was referred to our institution for further evaluation. Double-contrast small-bowel examination revealed strictures involving long segments of the distal ileum. Repeated barium enemas showed tumor in the sigmoid colon. Because she had a past history of radiation therapy for uterine cancer 27 years previously, radiation-associated colon cancer was suspected. She underwent Miles' operation and partial resection of the ileum. Intraoperative colonoscopy showed a polypoid lesion of type 1 in the sigmoid colon. Histopathologic examination of the resected specimen showed mucinous adenocarcinoma associated with radiation enterocolitis. (author)

  19. Comparison of glycoprotein expression between ovarian and colon adenocarcinomas

    DEFF Research Database (Denmark)

    Multhaupt, H A; Arenas-Elliott, C P; Warhol, M J

    1999-01-01

    distinguishing between these 2 entities. CONCLUSION: A panel of monoclonal antibodies against cytokeratins 7 and 20 antigens, CA125, and carcinoembryonic antigen is useful in differentiating serous and endometrioid adenocarcinomas of the ovary from colonic adenocarcinomas. Mucinous ovarian adenocarcinomas cannot......, carcinoembryonic antigen, and cytokeratins 7 and 20 to detect tumor-associated glycoproteins and keratin proteins in ovarian and colonic carcinomas. RESULTS: CA125, carcinoembryonic antigen, and cytokeratins 7 and 20 can distinguish between colonic and serous or endometrioid adenocarcinomas of the ovary in both...... primary and metastatic lesions. Mucinous ovarian adenocarcinomas differed in that they express carcinoembryonic antigen and cytokeratins 7 and 20 and weakly express CA125. The other glycoprotein antigens were equally expressed by ovarian and colonic adenocarcinomas and therefore were of no use in...

  20. Diagnostic Role of Colon Capsule Endoscopy in Patients with Optimal Colon Cleaning.

    Science.gov (United States)

    Akyüz, Ümit; Yılmaz, Yusuf; İnce, Ali Tüzün; Kaya, Bülent; Pata, Cengiz

    2016-01-01

    Background. Colon capsule endoscopy (CCE) is a diagnostic test with relatively rare usage. In this study, we aimed to evaluate both the optimal cleaning regimen for CCE and the diagnostic value of test in the study group. Methods. A total of 62 patients were enrolled in this study. In the first step, 3 different colon preparing regimens were given to 30 patients [Group A: 3 days of liquid diet, sodium phosphate (NaP) (90 mL), and NaP enema; Group B: 3 days of liquid diet, 4 L of polyethylene glycol (PEG), and metoclopramide; Group C: 3 days of liquid diet, 4 L of PEG, NaP (45 mL), and bisacodyl after capsule ingestion] (10 patients in each group). The other consecutive 32 patients were cleaned with the best regimen which was NaP + PEG and CCE was performed. The results of CCE were controlled with colonoscopy in 28 patients. Results. Group C had the highest cleaning score, compared with the other groups (2.2 ± 0.4 versus 2.7 ± 0.4 versus 3.7 ± 0.4, p value = 0.000). The CCE findings were as follows in 28 patients who were also examined with colonoscopy: polyp (range: 5-10 mm) in 6 patients, internal hemorrhoids in 3 patients, angiodysplasia in 1 patient, diverticula in 1 patient, and ulcerative colitis in 1 patient. The sensitivity, specificity, PPV, and NPV of CCE were 100%, 92%, 93%, and 100%, respectively. Conclusions. Low dosage NaP combined with PEG provides optimal bowel preparation for CCE. CCE appears to be a highly sensitive diagnostic modality for detecting colonic pathologies. PMID:27066070

  1. [Junk food revolution or the cola colonization].

    Science.gov (United States)

    Horinger, P; Imoberdorf, R

    2000-03-01

    In ancient times, the main problem was to get food. Nowadays the difficulty is to decide for or against some foodstuff. In industrialized countries, this abundance led to the fact that people eat differently from what they should. Traditional populations were subject to periods of feast and famine. Those with a metabolism which stored energy with high energetic efficiency had a survival advantage. This is called the 'thrifty' genotype hypothesis. With the secured supply of calories, coupled with a sedentary lifestyle, the thrifty genotype becomes disadvantageous, causing obesity. Industrialization or 'cola-colonization' also leads to a dramatic increase in obesity and non-insulin dependent diabetes mellitus in developing countries. The spread of fast food restaurants all over the world has changed modern nutrition fundamentally. Influence begins early in childhood. Advertising concentrates on the selling of image over substance. However, fast food contains high levels of fat, especially trans fatty acids. Higher consumption of trans fatty acids was associated with a higher incidence of and mortality from coronary heart disease. PMID:10756692

  2. Fungi colonizing dead leaves of herbs

    Directory of Open Access Journals (Sweden)

    Maria Kowalik

    2013-04-01

    Full Text Available The material was collected from the Botanical Garden and the Collegium Medicum Medicinal Plant Garden of the Jagiellonian University in Krakow. The investigated species were: lemon balm (Mellisa officinalis L., common lavender (Lavendula angustifolia Mill., horsemint (Mentha longifolia L., sage (Salvia officinalis L., sweet basil (Ocimum basilicum L., and wild marjoram (Origanum vulgare L.. The aim of the investigation was to identify fungi causing the death of leaf tissues of herbs from the mint family Lamiaceae. In mycological investigations, 180 fragments of each plant leaves (1,080 dead leaf fragments in total were placed in a 2% PDA medium. Over 970 colonies of fungi belonging to 48 species were isolated from the dead leaf tissues of the six herb species. Alternaria alternata (toxin-producing, Epicoccum nigrum and Sordaria fimicola were the most frequently isolated. The largest numbers of colonies and species of fungi were isolated from horsemint, while the lowest numbers were from wild marjoram leaves. It was shown that the death of leaves of selected herb species from the Lamiaceae family was caused by various fungi. The results of the mycological analysis confirmed the diversity of species colonizing the leaves of the herbs.

  3. Genetic analysis of Vibrio parahaemolyticus intestinal colonization.

    Science.gov (United States)

    Hubbard, Troy P; Chao, Michael C; Abel, Sören; Blondel, Carlos J; Abel Zur Wiesch, Pia; Zhou, Xiaohui; Davis, Brigid M; Waldor, Matthew K

    2016-05-31

    Vibrio parahaemolyticus is the most common cause of seafood-borne gastroenteritis worldwide and a blight on global aquaculture. This organism requires a horizontally acquired type III secretion system (T3SS2) to infect the small intestine, but knowledge of additional factors that underlie V. parahaemolyticus pathogenicity is limited. We used transposon-insertion sequencing to screen for genes that contribute to viability of V. parahaemolyticus in vitro and in the mammalian intestine. Our analysis enumerated and controlled for the host infection bottleneck, enabling robust assessment of genetic contributions to in vivo fitness. We identified genes that contribute to V. parahaemolyticus colonization of the intestine independent of known virulence mechanisms in addition to uncharacterized components of T3SS2. Our study revealed that toxR, an ancestral locus in Vibrio species, is required for V. parahaemolyticus fitness in vivo and for induction of T3SS2 gene expression. The regulatory mechanism by which V. parahaemolyticus ToxR activates expression of T3SS2 resembles Vibrio cholerae ToxR regulation of distinct virulence elements acquired via lateral gene transfer. Thus, disparate horizontally acquired virulence systems have been placed under the control of this ancestral transcription factor across independently evolved human pathogens. PMID:27185914

  4. Molecular Evolutionary Consequences of Island Colonization

    Science.gov (United States)

    James, Jennifer E.; Lanfear, Robert; Eyre-Walker, Adam

    2016-01-01

    Island endemics are expected to have low effective population sizes (Ne), first because some may experience population bottlenecks when they are founded, and second because they have restricted ranges. Therefore, we expect island species to have reduced genetic diversity, inefficient selection, and reduced adaptive potential compared with their mainland counterparts. We used both polymorphism and substitution data to address these predictions, improving on the approach of recent studies that only used substitution data. This allowed us to directly test the assumption that island species have small values of Ne. We found that island species had significantly less genetic diversity than mainland species; however, this pattern could be attributed to a subset of island species that appeared to have undergone a recent population bottleneck. When these species were excluded from the analysis, island and mainland species had similar levels of genetic diversity, despite island species occupying considerably smaller areas than their mainland counterparts. We also found no overall difference between island and mainland species in terms of the effectiveness of selection or the mutation rate. Our evidence suggests that island colonization has no lasting impact on molecular evolution. This surprising result highlights gaps in our knowledge of the relationship between census and effective population size. PMID:27358424

  5. Schwannoma de colon: reporte de un caso

    Directory of Open Access Journals (Sweden)

    Marlen Vega-Vega

    2003-06-01

    Full Text Available Los schwannomas del tracto gastrointestinal son muy raros, los más comúnmente encontrados son los de estómago. Se presenta un caso de un schwannoma de colon, el cual es aún menos común. Los schwannomas se han asociado con neurofibromatosis. La incidencia es igual en ambos sexos y el rango de edad es amplio, desde los 18 hasta los 87 años. Los síntomas más hallados son el sangrado, el dolor abdominal y la obstrucción intestinal. El método diagnóstico más certero es la tomografía axial computarizada. El tratamiento es quirúrgico y consiste en la resección completa del tumor; la quimioterapia y radioterapia no han mostrado resultados favorables. El pronóstico depende principalmente del tamaño del tumor, edad mayor de siete años, la necrosis del 25% del tumor o más y la presencia de neurofibromatosis.

  6. Colonic malakoplakia in a cardiac transplant recipient

    Directory of Open Access Journals (Sweden)

    Niamathullah Sadiya

    2014-08-01

    Full Text Available Malakoplakia is a rare inflammatory condition which is usually seen in the urogenital tract and less commonly in the gastrointestinal tract. Gastrointestinal malakoplakia may be associated with organ transplantation. There are previously only three reported cases of malakoplakia in cardiac transplant recipient. We report a case of colonic malakoplakia in a 38‑year‑old male who underwent cardiac transplantation for dilated cardiomyopathy 4 years previously and who had been on tacrolimus and mycophenolate. The patient presented with history of diarrhea associated with fecal incontinence for the past 6 months. Ileocolonoscopic examination was within normal limits. A rectal biopsy was done to exclude microscopic pathology. Microscopy revealed expansion of the lamina propria by histiocytes admixed with a few lymphocytes. The histiocytes showed granular eosinophilic cytoplasm with intracytoplasmic presence of Michaelis‑Gutmann bodies, rounded basophilic laminated structures having central core with a targetoid appearance. These stained positively for Von kossa stain for calcium and were diagnostic for malakoplakia. Although rare, malakoplakia may be associated with chronic diarrhea even if there are no macroscopic lesions seen during colonoscopy. The patient’s symptoms resolved with long‑term ciprofloxacin therapy

  7. Colonic abscess induced by India ink tattooing.

    Science.gov (United States)

    Bang, Chang Seok; Kim, Yeon Soo; Baik, Gwang Ho; Han, Sang Hak

    2014-07-01

    Endoscopic tattooing with India ink is generally regarded as a safe procedure that enables ready identification of endoluminal cancer from the serosal surface. However, significant complications have been reported, including local inflammatory pseudotumor formation, peritonitis, rectus muscle abscess, small bowel infarction, and phlegmonous gastritis. Although the mechanism of complication is not completely understood, it may be related to the chemical compounds contained in the ink solution and enteric or extraenteric bacterial inoculation by injection needle or the ink itself. Authors encountered a case of a 60-year-old man with a resectable sigmoid colon cancer which was tattooed with India ink for subsequent localization in the intraoperative setting. During the laparoscopic operation, the proximal and distal margin of the lesion appeared edematous with bluish color. The distal resection margin was extended approximately 5 cm more than expected because of long extent of edematous mucosa. Histologic examination of the edematous tattooing area revealed an ink abscess spreading laterally above the muscularis propria. Although tattooing is widely used and relatively safe, the presented case indicates the risk of infection or inflammation by tattooing. PMID:25073671

  8. A Hierarchical Probability Model of Colon Cancer

    CERN Document Server

    Kelly, Michael

    2010-01-01

    We consider a model of fixed size $N = 2^l$ in which there are $l$ generations of daughter cells and a stem cell. In each generation $i$ there are $2^{i-1}$ daughter cells. At each integral time unit the cells split so that the stem cell splits into a stem cell and generation 1 daughter cell and the generation $i$ daughter cells become two cells of generation $i+1$. The last generation is removed from the population. The stem cell gets first and second mutations at rates $u_1$ and $u_2$ and the daughter cells get first and second mutations at rates $v_1$ and $v_2$. We find the distribution for the time it takes to get two mutations as $N$ goes to infinity and the mutation rates go to 0. We also find the distribution for the location of the mutations. Several outcomes are possible depending on how fast the rates go to 0. The model considered has been proposed by Komarova (2007) as a model for colon cancer.

  9. Prevalence of advanced colonic polyps in asymptomatic Chinese

    Institute of Scientific and Technical Information of China (English)

    Hui-Hsiung Liu; Meng-Chen Wu; Yeh Peng; Ming-Shiang Wu

    2005-01-01

    AIM: To investigate the prevalence of advanced polyps in asymptomatic Chinese and to determine the risk of proximal advanced colonic polyps in subjects with and without polyps in the distal colon.METHODS: Data were collected prospectively during colonoscopic examinations performed in 5 973 subjects as part of health evaluation at our unit from December 1997 to December 2003. Polyps were considered advanced, if they were larger than 10 mm or were tubovillous, villous or malignant. Proximal colon was defined as the splenic flexure and more proximal portions of the colon.RESULTS: Colon polyps were detected in 971 (16.3%)subjects (613 males and 358 females) with their mean age being 56.6±10.7 years. Advanced polyps were noted in 199 (3.3%) individuals. Subjects were sub-classified according to the location of polyps into three groups: distal (569, 58.6%), proximal (284, 29.2%), and combined proximal and distal (118, 12.2%) groups. Subjects with advanced polyps in these three groups were 95 (9.8%),56 (5.8%), and 48 (4.9%) respectively. In the 48 subjects with advanced combined polyps, 13 advanced polyps were distributed at the distal colon, 17 at the proximal colon,and 18 at both. Eighteen colon cancers including 12 at sigmoid and 6 at ascending colon were confirmed by final pathology. The relative risk for advanced proximal polyp according to distal findings was 3.1 (95%CI: 1.3-7.4) for hyperplastic polyp, 2.7 (95%CI: 1.4-5.3) for tubular polyp and 13.5 (95%CI: 5.1-35.4) for advanced polyp as compared to that for no polyp. However, 56 (28.2%) of 199 subjects with advanced polyps had no index polyps at the distal colon and might go undetected under sigmoidoscopic screening.CONCLUSION: Although distal lesions can predict the risk of advanced proximal polyps, a substantial portion of Chinese with advanced proximal polyps is not associated with any distal sentinel lesions. These data have implications for screening policy of colon cancers in Taiwanese Chinese.

  10. Improved survival with early adjuvant chemotherapy after colonic resection for stage III colonic cancer

    DEFF Research Database (Denmark)

    Klein, Mads; Azaquoun, Najah; Jensen, Benny Vittrup;

    2015-01-01

    BACKGROUND AND OBJECTIVES: In stage III colonic cancer, time from surgery to start of adjuvant chemotherapy may influence survival. In this study, we evaluated the effect of timing of adjuvant therapy on survival. METHODS: Database study from the Danish Colorectal Cancer Group's national database....... RESULTS: The final population included 1,827 patients scheduled for adjuvant chemotherapy. Adjuvant therapy started within 4 and 8 weeks improved survival when compared to start later than 8 weeks (HR [95%CI]: 1.7 [1.1-2.6]; P = 0.024 and 1.4 [1.07-1.8]; P = 0.013, respectively), whereas there was no...

  11. How well does stool form reflect colonic transit?

    OpenAIRE

    Degen, L P; Phillips, S F

    1996-01-01

    BACKGROUND: Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM: To examine the relations between stool form and gastric emptying, small bowel and colonic transit. METHODS: Regional gut transit was assessed scintigraphically and segmental colonic transit was al...

  12. Hyaluronic acid changes of the extracellular matrix in colon carcinoma

    OpenAIRE

    Arab MR.; Allahyari A.; Sargolzaie Aval F.; Rafighdoost H; Karimi M

    2007-01-01

    Background: The extracellular matrix is a complex three-dimensional network of proteins and glycosaminoglycans, which have important roles in cellular physiology and cell-cell and cell-extracellular matrix interactions. Any changes in the extracellular matrix of tumors may be implicated in cellular transformation and metastasis. The aim of the present study was to identify changes in the hyaluronic acid of the stroma of colonic carcinoma.Methods: Paraffin blocks of 30 patients with colon carc...

  13. Metachronous schwannoma in the colon with vestibular schwannoma

    OpenAIRE

    Jung, Eun-Joo; Han, Hye Seung; Koh, Young-Cho; Cho, Joon; Ryu, Chun-Geun; Paik, Jin Hee; Hwang, Dae-Yong

    2014-01-01

    We experienced a case of vestibular schwannoma and metachronous schwannoma in the colon. A 59-year-old female presented with a 1-month history of hematochezia. She had undergone suboccipital craniectomy resulting in radical subtotal resection, followed by gamma knife radiosurgery for a large left vestibular schwannoma 4 years prior to admission. On preoperative colonoscopy, a huge mass through which the colonoscope could not be passed was detected. CT scans showed colo-colonic intussusception...

  14. Rare Synchronous Gastrointestinal Plasmacytomas of Colon and Stomach

    Science.gov (United States)

    Sethi, Supreet; Dang, Shyam; Aduli, Farshad

    2015-01-01

    Gastrointestinal (GI) plasmacytomas, though relatively uncommon, can occur with or without multiple myeloma. The small intestine is the most commonly involved GI site, followed by stomach, colon, and esophagus. Synchronous plasmacytomas involving 2 anatomically distinct regions of gastrointestinal tract have never been reported in the literature. We report a case of a multiple myeloma patient who had acute-onset hematochezia and was found to have synchronous plasmacytomas of the colon and stomach. PMID:26203446

  15. Rare Synchronous Gastrointestinal Plasmacytomas of Colon and Stomach

    OpenAIRE

    Syal, Gaurav; Sethi, Supreet; Dang, Shyam; Aduli, Farshad

    2015-01-01

    Gastrointestinal (GI) plasmacytomas, though relatively uncommon, can occur with or without multiple myeloma. The small intestine is the most commonly involved GI site, followed by stomach, colon, and esophagus. Synchronous plasmacytomas involving 2 anatomically distinct regions of gastrointestinal tract have never been reported in the literature. We report a case of a multiple myeloma patient who had acute-onset hematochezia and was found to have synchronous plasmacytomas of the colon and sto...

  16. Acidic microenvironment and bone pain in cancer-colonized bone

    OpenAIRE

    Yoneda, Toshiyuki; Hiasa, Masahiro; Nagata, Yuki; Okui, Tatsuo; White, Fletcher A.

    2015-01-01

    Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-related complications. Bone pain is one of the most common complications associated with cancer colonization in bone and a major cause of increased morbidity and diminished quality of life, leading to poor survival in cancer patients. Although the mechanisms responsible for cancer-associated bone pain (CABP) are poorly understood, it is likely that complex interactions among cancer cells, bone cells and periphe...

  17. Death from colonic disease in epidermolysis bullosa dystrophica

    OpenAIRE

    Lin Gau-Tyan; Huang Che-Jen; Hsieh Chih-Hsin

    2006-01-01

    Abstract Background Squamous cell carcinomas and renal failure were reported the causes of death in patients with recessive dystrophic epidermolysis bullosa (RDEB). Death from colonic disease in epidermolysis bullosa (EB) is never reported. Case presentation We demonstrate a male patient with RDEB. He suffered megacolon due to fecal impaction and died from sigmoid colon perforation with peritonitis at age 35 years. Conclusion Constipation is a common clinical feature of RDEB, but fetal compli...

  18. Colonic irrigation for defecation disorders after dynamic graciloplasty

    OpenAIRE

    Koch, Sacha M.; Uludağ, Özenç; El Naggar, Kadri; van Gemert, Wim G.; Baeten, Cor G.

    2007-01-01

    Background and aims Dynamic graciloplasty (DGP) improves anal continence and quality of life for most patients. However, in some patients, DGP fails and fecal incontinence is unsolved or only partially improved. Constipation is also a significant problem after DGP, occurring in 13–90%. Colonic irrigation can be considered as an additional or salvage treatment for defecation disorders after unsuccessful or partially successful DGP. In this study, the effectiveness of colonic irrigation for the...

  19. EZH2 depletion blocks the proliferation of colon cancer cells.

    Directory of Open Access Journals (Sweden)

    Bettina Fussbroich

    Full Text Available The Enhancer of Zeste 2 (EZH2 protein has been reported to stimulate cell growth in some cancers and is therefore considered to represent an interesting new target for therapeutic intervention. Here, we investigated a possible role of EZH2 for the growth control of colon cancer cells. RNA interference (RNAi-mediated intracellular EZH2 depletion led to cell cycle arrest of colon carcinoma cells at the G1/S transition. This was associated with a reduction of cell numbers upon transient transfection of synthetic EZH2-targeting siRNAs and with inhibition of their colony formation capacity upon stable expression of vector-borne siRNAs. We furthermore tested whether EZH2 may repress the growth-inhibitory p27 gene, as reported for pancreatic cancer. However, expression analyses of colon cancer cell lines and colon cancer biopsies did not reveal a consistent correlation between EZH2 and p27 levels. Moreover, EZH2 depletion did not re-induce p27 expression in colon cancer cells, indicating that p27 repression by EZH2 may be cell- or tissue-specific. Whole genome transcriptome analyses identified cellular genes affected by EZH2 depletion in colon cancer cell lines. They included several cancer-associated genes linked to cellular proliferation or invasion, such as Dag1, MageD1, SDC1, Timp2, and Tob1. In conclusion, our results demonstrate that EZH2 depletion blocks the growth of colon cancer cells. These findings might provide benefits for the treatment of colon cancer.

  20. Colon cancer chemoprevention with ginseng and other botanicals.

    OpenAIRE

    Wargovich, M J

    2001-01-01

    Colorectal cancer is becoming increasingly common in Asian countries and still remains the second leading cause of cancer deaths in the United States. Efforts to prevent colon cancer have targeted early detection through screening and chemoprevention. For the last ten years our laboratory has utilized an in vivo screening assay for the testing of potential cancer preventives for colon cancer. We have conducted investigations on over 150 compounds including many with botanical or herbal origin...

  1. Microchimerism and survival after breast and colon cancer diagnosis

    OpenAIRE

    Kamper-Jørgensen, Mads

    2012-01-01

    Recently, we reported microchimerism to be oppositely associated with maternal breast and colon cancer. In women with a blood test positive for male microchimerism the risk of breast cancer development was reduced to one third, whereas the risk of colon cancer was elevated 4-fold. In this article addendum, I report the survival of cases in the original study after being diagnosed with cancer. Despite small numbers, the analysis suggests that microchimerism may be positively associated with su...

  2. A case of leptospirosis simulating colon cancer with liver metastases

    OpenAIRE

    Granito, Alessandro; Ballardini, Giorgio; Fusconi, Marco; Volta, Umberto; Muratori, Paolo; Sambri, Vittorio; Battista, Giuseppe; Bianchi, Francesco B.

    2004-01-01

    We report a case of a 61-year-old man who presented with fatigue, abdominal pain and hepatomegaly. Computed tomography (CT) of the abdomen showed hepatomegaly and multiple hepatic lesions highly suggestive of metastatic diseases. Due to the endoscopic finding of colon ulcer, colon cancer with liver metastases was suspected. Biochemically a slight increase of transaminases, alkaline phosphatase and gammaglutamyl transpeptidase were present; α - fetoprotein, carcinoembryogenic antigen and carbo...

  3. A novel colonic anastomosis technique involving fixed polyglycolic acid mesh

    OpenAIRE

    Aysan, Erhan; Bektas, Hasan; Ersoz, Feyzullah; Sari, Serkan; Kaygusuz, Arslan

    2010-01-01

    Background: Polyglycolic acid mesh (PAM) reinforcement of colonic anastomoses were evaluated. Methods: Twenty female albino rabbits were divided into two groups. Each rabbit underwent segmental colonic resection with single-layer anastomosis. In one group of rabbits, PAM of length equal to the circumference of the anastomosis was applied. Rabbits were sacrificed on postoperative day 10 and peritoneal adhesions, anastomosis burst pressure, and anastomosis histopathological characteristics were...

  4. Fast colon centreline calculation using optimised 3D topological thinning

    OpenAIRE

    Sadlier, Robert J.T.; Whelan, Paul F.

    2005-01-01

    Topological thinning can be used to accurately identify the central path through a computer model of the colon generated using computed tomography colonography. The central path can subsequently be used to simplify the task of navigation within the colon model. Unfortunately standard topological thinning is an extremely inefficient process. We present an optimised version of topological thinning that significantly improves the performance of centreline calculation without compromising the accur...

  5. Comparative effects of enoxacin and norfloxacin on human colonic microflora.

    OpenAIRE

    Edlund, C; Lidbeck, A.; Kager, L; Nord, C E

    1987-01-01

    Ten healthy volunteers received 400 mg of enoxacin and another ten healthy volunteers received 200 mg of norfloxacin orally twice a day for 7 days. Fecal specimens were collected before, during, and after drug administration to study the impact of enoxacin and norfloxacin on the normal colonic microflora. On day 7, the mean concentrations of enoxacin and norfloxacin were 350 and 950 mg/kg of feces, respectively. Enoxacin and norfloxacin affected the colonic microflora in similar ways. The num...

  6. A dangerous joke: Colon perforation by an air compressor

    OpenAIRE

    HAZAR, Erkan; Kayipmaz, Afsin Emre; Coskun, Abuzer; Ozbay, Sedat; Okur, Osman Mahir; Ozkan, Ilham; Eren, Sevki Hakan; Kavalci, Cemil

    2015-01-01

    The most dangerous complication of air entry into rectum at a high volume and velocity in a short time are sigmoid colon rupture and pneumoperitoneum.We present a 28-year-old male was brought to emergency with abdominal nausea, vomiting, pain, and abdominal swelling for 4 hours. Based on physical examination and laboratory data the patient was taken to operating theatre for suspected acute appendicitis. On exploration an excessive amount of gas distention was observed in whole colon with caec...

  7. Edited Volumes, Monographs, and Book Chapters in the Book Citation Index (BCI) and Science Citation Index (SCI, SoSCI, A&HCI)

    CERN Document Server

    Leydesdorff, Loet

    2012-01-01

    In 2011, Thomson-Reuters introduced the Book Citation Index (BCI) as part of the Science Citation Index (SCI). The interface of the Web of Science version 5 enables users to search for both "Books" and "Book Chapters" as new categories. Books and book chapters, however, were always among the cited references, and book chapters have been included in the database since 2005. We explore the two categories with both BCI and SCI, and in the sister databases for the social sciences (SoSCI) and the arts and humanities (A&HCI). Book chapters in edited volumes can be highly cited. Books contain many citing references, but are relatively less cited. We suggest that this may find its origin in the slower circulation of books then of journal articles. It is possible to distinguish scientometrically between monographs and edited volumes among the "Books". Monographs may be underrated in terms of citation impact or overrated using publication performance indicators because individual chapters are counted separately as ...

  8. Early colon cancer : findings on double contrast barium enema

    International Nuclear Information System (INIS)

    The purpose of this study is to describe the radiologic findings of early colon cancer on double-contrast barium enema. We retrospectively reviewed the double-contrast barium enemas of eight patients (M:F = 6:2; mean age : 67 yrs; range : 48-77 yrs) who were pathologically proven to be early colon cancer. The location, size and gross morphology of lesions was evaluated using double-contrast barium enema, while depth of invasion, degree of differentiation, precancerous lesions and lymph node metastasis were evaluated histopathologically. Early colon cancer was found in the rectum (n=4), sigmoid colon (n=3) and ascending colon (n=1). The size of mass ranged from 2.3 ∼ 8.3 (mean, 4.6) cm. And the polypoid type was most common (n=7); this was subdivided into sessile (Is, n=5), semipedunculated (Isp, n=1) and pedunculated type (Ip, n=1). Another mass was a sessile polypoid combined with a flat depressed lesion. In eight cases, four cancers were confined to the mucosa, while the remaining four had infiltrated the submucosa. Most cancers arose from villous and villotubular adenoma. All cases were well-differentiated adenocarcinoma and no metastasis to lymph nodes had occurred. In early colon cancer, lesions were mainly polypoid and large. Most arose from villous and villotubular adenoma. (author). 19 refs., 1 tab., 3 figs

  9. Ogilvie's syndrome-acute colonic pseudo-obstruction.

    Science.gov (United States)

    Pereira, P; Djeudji, F; Leduc, P; Fanget, F; Barth, X

    2015-04-01

    Ogilvie's syndrome describes an acute colonic pseudo-obstruction (ACPO) consisting of dilatation of part or all of the colon and rectum without intrinsic or extrinsic mechanical obstruction. It often occurs in debilitated patients. Its pathophysiology is still poorly understood. Since computed tomography (CT) often reveals a sharp transition or "cut-off" between dilated and non-dilated bowel, the possibility of organic colonic obstruction must be excluded. If there are no criteria of gravity, initial treatment should be conservative or pharmacologic using neostigmine; decompression of colonic gas is also a favored treatment in the decision tree, especially when cecal dilatation reaches dimensions that are considered at high risk for perforation. Recurrence is prevented by the use of a multiperforated Faucher rectal tube and oral or colonic administration of polyethylene glycol (PEG) laxative. Alternative therapeutic methods include: epidural anesthesia, needle decompression guided either radiologically or colonoscopically, or percutaneous cecostomy. Surgery should be considered only as a final option if medical treatments fail or if colonic perforation is suspected; surgery may consist of cecostomy or manually-guided transanal pan-colorectal tube decompression at open laparotomy. Surgery is associated with high rates of morbidity and mortality. PMID:25770746

  10. Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD

    Directory of Open Access Journals (Sweden)

    Sadegh Khodavaisy

    2015-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. Cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. Pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, although the low levels of its DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. The increased prevalence of P. jirovecii colonization in COPD patients has led to an interest in understanding its role in the disease. P. jirovecii colonization in these patients could represent a problem for public health since colonized patients could act as a major reservoir and source of infection for susceptible subjects. Using sensitive molecular techniques, low levels of P. jirovecii DNA have been detected in the respiratory tract of certain individuals. It is necessary to elucidate the role of P. jirovecii colonization in the natural history of COPD patients in order to improve the clinical management of this disease. In the current review paper, we discuss P. jirovecii colonization in COPD patients.

  11. Species Turnover through Time: Colonization and Extinction Dynamics across Metacommunities.

    Science.gov (United States)

    Nuvoloni, Felipe Micali; Feres, Reinaldo José Fazzio; Gilbert, Benjamin

    2016-06-01

    Island biogeography and metacommunity theory often use equilibrium assumptions to predict local diversity, yet nonequilibrium dynamics are common in nature. In nonequilibrium communities, local diversity fluctuates through time as the relative importance of colonization and extinction change. Here, we test the prevalence and causes of nonequilibrium dynamics in metacommunities of mites associated with rubber trees distributed over large spatial (>1,000 km) and temporal (>30-60 generations) scales in Brazil. We measured colonization and extinction rates to test species turnover and nonequilibrium dynamics over a growing season. Mite metacommunities exhibited nonequilibrium dynamics for most months of the year, and these dynamics tracked climatic conditions. Monthly shifts in temperature of more than 1°C resulted in nonequilibrium dynamics, as did mean temperatures outside of two critical ranges. Nonequilibrium dynamics were caused by a change in colonization with temperature change and changes in both colonization and extinction with absolute temperature. Species turnover showed different trends; high relative humidity increased both colonization and extinction rates, increasing turnover but not nonequilibrium dynamics. Our study illustrates that testing nonequilibrium dynamics can provide new insights into the drivers of colonization, extinction, and diversity fluctuations in metacommunities. PMID:27172597

  12. Hypoxia inhibits colonic ion transport via activation of AMP kinase.

    LENUS (Irish Health Repository)

    Collins, Danielle

    2012-02-01

    BACKGROUND AND AIMS: Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mucosal function through inhibition of chloride secretion. However, the molecular mechanisms underlying this observation are poorly understood. AMP-activated protein kinase (AMPK) is a metabolic energy regulator found in a wide variety of cells and has been linked to cystic fibrosis transmembrane conductance regulator (CFTR) mediated chloride secretion in several different tissues. We hypothesized that AMPK mediates many of the acute effects of hypoxia on human and rat colonic electrolyte transport. METHODS: The fluorescent chloride indicator dye N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide was used to measure changes in intracellular chloride concentrations in isolated single rat colonic crypts. Ussing chamber experiments in human colonic mucosa were conducted to evaluate net epithelial ion transport. RESULTS: This study demonstrates that acute hypoxia inhibits electrogenic chloride secretion via AMPK mediated inhibition of CFTR. Pre-treatment of tissues with the AMPK inhibitor 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo [1,5-a] pyrimidine (compound C) in part reversed the effects of acute hypoxia on chloride secretion. CONCLUSION: We therefore suggest that AMPK is a key component of the adaptive cellular response to mucosal hypoxia in the colon. Furthermore, AMPK may represent a potential therapeutic target in diseased states or in prevention of ischemic intestinal injury.

  13. Yersinia enterocolitica Monographic Study

    OpenAIRE

    Emil Tirziu; Ciceronis Cumpanasoiu; Radu Valentin Gros; Monica Seres

    2011-01-01

    Germs from Yersinia genus have a vast ecologic niche, being met at different domestic and wild animal species, but also in food, water and soil. The majority of yersinis live in the digestive tract of human and numerous animal species, especially rodents, but also in soil, plant debris, waters etc. Numerous species of Yersinia genus could produce characteristic infections in human, the main source of infections is represented by rodents and hematophagous insects or, more frequently, by water ...

  14. Monograph: Concluding Remarks

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    Full Text Available Private investment in biomedical research has increased over the last few decades. At most places it has been welcomed as the next best thing to technology itself. There are significant costs involved too. Major areas of conflict of interest especially applicable to biomedical research have arisen, as academia interacts with industry. Pharma image stinks because of a number of errors of omission and commission. A recent example is suppression of negative findings about Bayer's Trasylol (Aprotinin and the marketing maneuvers of Eli Lilly's Xigris (rhAPC. A voluntary moratorium over pharma spending to pamper drug prescribers is necessary.The integrity of industry-sponsored clinical research has come under increasing scrutiny. The basic shizm is between the value system of a patient welfare driven professional and that of a profit driven industry . While one wants to avoid control but wants the dough, the other wants to exercise the control by supplying the dough. Clinical practice guidelines (CPG are considered important as they guide diagnostic/therapeutic regimen of a large number of medical professionals and hospitals and provide recommendations on drugs, dosages and criteria for selection. Besides clinical trials, they are another area of growing influence by the pharmaceutical industry. For example, in a recent survey it was found that about 60% of 192 authors of clinical practice guidelines reported they had financial connections with the companies whose drugs were under consideration. This finding casts serious doubt on the credibility of this important pillar of modern clinical practice. It needs urgent reparative action. One of them is prospective and retrospective disclosure of financial conflict of interest by authors of CPGs.A Conference on Guideline Standardization (COGS was convened in April 2002 'to define a standard for guideline reporting that would promote guideline quality and facilitate implementation'. It includes items for standardization, conceptual issues, up gradation, conflict of interest, patient interest and systematization. Even items for individual preferences, choice or values are not neglected. Special mention must be made of items that specify disclosure of conflict of interest both in the Developer (including the organization that develops and the individuals involved in the guideline's formulation, as well as in the sponsor or funding source (and its role in developing and/or reporting the guideline.Recommendations of CPGs and CDR panels are conflicting. One considers effectiveness, the other cost-effectiveness. However, CPGs do not adhere to established methodological standards; critical information that would attest to validity is regularly absent; explicit criteria to grade scientific evidence that supports their recommendations is absent from 82% of guidelines; 87% are not in a position to report whether a systematic literature search was performed; 67% do not describe the type of professionals used in guidelines development; and there is marked variation in the quality of guidelines. Moreover, CPG guideline layers often are conflicted in their interests. The problem can be resolved to a large extent by taking a simple step: making CPG panelists go into cost effectiveness along with recommending Guidelines. What then happens is they have to consider not only effectiveness but also costs. Effectiveness can be fudged, cost cannot. Why? Because, what is the cost is well known. Therapies in Guidelines should be recommended and graded according to whether they are Most, Moderately or Least Cost Effective. For that CPGs will have to perform an economic analysis as well. This will meet with resistance for obvious reasons. Since guideline groups cannot be kept on the straight and narrow path and till we find fool proof ways of keeping them thus, we have no option but to stress that under no circumstances they can mislead, or get misled themselves, in the name of patient advocacy, to recommend costly new therapies which have still not proved their effectiveness conclusively, nor get away with conflicted recommendations, which it is still not obligatory to reveal. A simple rider like making it mandatory for guideline groups to go into both effectiveness and cost effectiveness takes care that this is ensured.The AGREE Collaboration (AGREE stands for Appraisal of Guidelines, Research and Evaluation has created and validated tools by which clinicians can themselves rate guidelines by identifying factors that determine their quality. To facilitate this process, a body like the GAC (Guidelines Advisory Committee applies the AGREE criteria to individual guidelines and rates and endorses the best possible guideline. Clinical Practice Guidelines are another example of an excellent idea likely to go to seed due to sponsor manipulation and forces of the market place camouflaging as evidence based medicine. The need to weed out conflicted experts and make the process of therapy selection transparent must go hand in hand with laying down clear-cut criteria for guideline formulation and rejection of conflicted submissions by vigilant journal publication policies and editors. A number of disease-specific foundations are heavily funded by industry that creates serious conflict of interest likely to result in favourably recommending therapies of sponsors. The case of Alteplase and the American Heart Foundation is a recent example. Whistle blowing papers and research to expose misdemeanours must be undertaken and journals and their editors should welcome such papers as legitimate research, without encouraging a witch-hunt. The USP of journals and researchers is credibility. Credibility can be marketed, but it can't be bought. Sponsors will be forced to seek such credibility without allowing them to compromise it. Such is the game journal publishers/editors and genuine researchers will have to play with sponsors. But they can do so only if they are thoroughly competent and have abiding faith in an uncompromising set of ethical values. The Task Force of the AAMC, in its two reports of 2001 and 2002, recognises the necessity and inevitability of the academia-industry connect, but wants to avoid its undesirable influence on the integrity of research and the welfare of human research subjects. It is specially concerned that public, activist and governmental control and concern does not cast a spanner in the works of a potentially promising relationship.Constant pampering by sponsors has dulled most drug prescribers' critical capabilities. Sponsorship is a potent anaeasthetic to many ethical concerns. It can blunt the thrust of many a sabre-rattling critic.Both medical associations and research journal editors are getting concerned with individual and institutional conflicts of interest in the conduct of clinical research and documents are now available which address these issues.Edits are concerned with whether academic medicine is for sale (Angell, in N Engl J Med 2000; what are the controlling interests of research (Editorial, CMAJ, 2002a; how the invisible hand of the marketing department works (Editorial, CMAJ , 2002b; how contracts affect institutions and academic freedom (Drazen in N Engl J Med , 2002; what are the choices for the academic medical center in collaborating with industry - (Moses et al in N Engl J Med , 2002; how does one ensure integrity of scientific research (Editorial, Lancet , 2002; how one maintains public trust in clinical research (Kelch in N Engl J Med , 2002; how does one ensure academic freedom in clinical research (Nathan and Weatherall, editorial, in N Engl J Med 2002; how to maintain the integrity of the scientific record (Smith R.: [editorial]. BMJ 2001; and is the university-industrial complex going out of control? ( Nature , 2001. The 2001 ICMJE revision call for full disclosure of the sponsor's role in research, as well as assurance that investigators are independent of sponsors, are fully accountable for the design and conduct of the trial, have independent access to all trial data and control all editorial and publication decisions. ICMJE has taken an important step in ensuring greater accountability in the research process, its publication and preventing possible malevolent impact on gullible readers. However the findings of a 2002 study suggest that academic institutions routinely participate in clinical research that does not adhere to ICMJE standards of accountability, access to data and control of publication. An issue of major concern is protection of the interests of research subjects because patients agree to become research subjects not only for personal medical benefit but, as an extension, to benefit the rest of the patient population and also advance medical research. These interests are hardly served if research data is doctored or concealed, as can happen to protect industry interests or if industry dictates the terms and conditions of research contracts.The progress of biomedical research depends on ready availability of research subjects. But such ready availability depends on ethical practices by researchers and sponsoring agencies. The clear-cut power to protect research subjects' interests should be inbuilt in the contract process. Establishment of Best Practice Guidelines for researchers and academic medical centers and Good Publication Practice for sponsoring pharmaceuticals are two important developments worth a close study and replication to assess feasibility across diverse geographical areas. Another area of concern is pharma's focus on the marketability rather than usefulness of products. There is an inevitable slant to produce not necessarily useful but marketable products which ensure profitability of industry and research grants outflow to academia. A disturbing but very relevant finding in this connection is that drugs which can be called "substantial improvements" over available treatments is only, mark the finding, a measly 6%. Industry supports new therapies, not traditional therapy, irrespective of what is effective. Whatever traditional therapy is supported is also most probably because the industry concerned has a product with a big stake there, which has remained a 'gold standard' or which that player thinks still has some 'juice' left.The larger issue of benefit to society also concerns us here when we realize that industry sponsorship is mainly for potential medications, not for trying to determine whether there may be non-pharmacological interventions that may be equally good, if not better. This is the reason why methods like yoga, psychotherapy, meditation, non-medicated non-mechanised relaxation will not find industry sponsors readily and will never be proved useful apart from anecdotal reporting.In the paradigm shift towards biological psychiatry, the role of industry sponsorship is not overt but probably more pervasive than many have realized or the right thinking may consider good for the health of the branch in the long run. Ask yourself a simple question: Why should industry sponsor psychotherapeutic research? And why should industry not sponsor biological research? Which of the two will give rise to drugs? How will the profits pour in? The answer is simple enough.Essentially, there are four types of drugs. First, drugs that work and have minimal side-effects; second, drugs which work but have serious side-effects; third, drugs that do not work but have minimal side-effects; and fourth, drugs which work minimally but have serious side-effects. Pharma's major propelling force can only be producing the first type. They accept the second type only till they can lay their hands on the first and, in any case, never project or accept them as the first. The third type can be occasionally played around with to shore up profits, but never by projecting them as the first type. The fourth type are the laggards, a real threat to credibility and therefore do not deserve any market hype or promotion. What makes pharma adopt even questionable means to make profits? Reasons are mainly three: one, pharma business cannot depend only on genuine discoveries; second, newer drugs with no effect are also with no, or little, side-effects - and that helps; and third, image building needs to balance profit with shored up credibility. Industry players have to strike the right balance between profit making and credibility. In profit making, the marketing champions play their role. In credibility ratings, researchers and paid spokes-persons play their role. All is hunky dory till marketing is based on credibility. When there is nothing available to make for credibility, something is projected as one and marketing carried out, in the calculated hope that profits can accrue, since that must continue endlessly. That is what makes pharma adopt even questionable means to make profits.The process of self-correction set into motion due to greater clout of conscientious researchers, unrelenting expose by medical journalists and supportive editors, patients right activism and law suits against industry will, hopefully, help tilt the balance towards value-based advance, even if belated, and done grudgingly. Major industry players may soften the offensive of such self-correction only by playing the game according to the rules. The earlier the major players understand this, the better it is for all concerned.

  15. Monograph: Concluding Remarks

    OpenAIRE

    Singh, Ajai R.; Singh, Shakuntala A.

    2007-01-01

    Private investment in biomedical research has increased over the last few decades. At most places it has been welcomed as the next best thing to technology itself. There are significant costs involved too. Major areas of conflict of interest especially applicable to biomedical research have arisen, as academia interacts with industry. Pharma image stinks because of a number of errors of omission and commission. A recent example is suppression of negative findings about Bayer's Trasylol (Aprot...

  16. Solarium primer. [Monograph

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    Solaria can be used to collect solar energy for space heating and provide an open environment. This primer introduces the basic concepts of an energy-efficient solarium and provides information on the practical aspects of siting, design, and construction. The horticultural use of a solarium as a greenhouse is not dealt with except in explaining the influence this may have on its design and operation. The book shows the characteristics of different types of solaria, their advantages as well as their limitations. It also explains the prerequisite of a successful addition to an existing home. Design and construction details accompany the text. 73 references, 2 tables.

  17. Clinical impact of Achromobacter xylosoxidans colonization/infection in patients with cystic fibrosis

    OpenAIRE

    Firmida, M.C.; R.H.V. Pereira; E.A.S.R. Silva; E.A. Marques; A.J. Lopes

    2016-01-01

    The rate of diagnosis of colonization/infection of the airways with Achromobacter xylosoxidans has increased in cystic fibrosis patients, but its clinical significance is still controversial. This retrospective, case-control study aimed to evaluate the clinical impact of A. xylosoxidans colonization/infection in cystic fibrosis patients. Individuals who were chronically colonized/infected (n=10), intermittently colonized/infected (n=15), and never colonized/infected with A. xylosoxidans (n=18...

  18. Colonic immune stimulation by targeted oral vaccine.

    Directory of Open Access Journals (Sweden)

    Mahesh Kathania

    Full Text Available BACKGROUND: Currently, sufficient data exist to support the use of lactobacilli as candidates for the development of new oral targeted vaccines. To this end, we have previously shown that Lactobacillus gasseri expressing the protective antigen (PA component of anthrax toxin genetically fused to a dendritic cell (DC-binding peptide (DCpep induced efficacious humoral and T cell-mediated immune responses against Bacillus anthracis Sterne challenge. METHODOLOGY/PRINCIPAL FINDING: In the present study, we investigated the effects of a dose dependent treatment of mice with L. gasseri expressing the PA-DCpep fusion protein on intestinal and systemic immune responses and confirmed its safety. Treatment of mice with different doses of L. gasseri expressing PA-DCpep stimulated colonic immune responses, resulting in the activation of innate immune cells, including dendritic cells, which induced robust Th1, Th17, CD4(+Foxp3(+ and CD8(+Foxp3(+ T cell immune responses. Notably, high doses of L. gasseri expressing PA-DCpep (10(12 CFU were not toxic to the mice. Treatment of mice with L. gasseri expressing PA-DCpep triggered phenotypic maturation and the release of proinflammatory cytokines by dendritic cells and macrophages. Moreover, treatment of mice with L. gasseri expressing PA-DCpep enhanced antibody immune responses, including IgA, IgG(1, IgG(2b, IgG(2c and IgG(3. L. gasseri expressing PA-DCpep also increased the gene expression of numerous pattern recognition receptors, including Toll-like receptors, C-type lectin receptors and NOD-like receptors. CONCLUSION/SIGNIFICANCE: These findings suggest that L. gasseri expressing PA-DCpep has substantial immunopotentiating properties, as it can induce humoral and T cell-mediated immune responses upon oral administration and may be used as a safe oral vaccine against anthrax challenge.

  19. Type I Interferons Direct Gammaherpesvirus Host Colonization.

    Science.gov (United States)

    Tan, Cindy S E; Lawler, Clara; May, Janet S; Belz, Gabrielle T; Stevenson, Philip G

    2016-05-01

    Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IFN-I responding cells. Epithelial-derived MuHV-4 showed low IFN-I exposure, and neither disrupting viral evasion nor blocking IFN-I signalling markedly affected acute viral replication in the lungs. Maximising IFN-I induction with poly(I:C) increased virus tagging in lung macrophages, but the tagged virus spread poorly. Lymphoid-derived MuHV-4 showed contrastingly high IFN-I exposure. This occurred mainly in B cells. IFN-I induction increased tagging without reducing viral loads; disrupting viral evasion caused marked attenuation; and blocking IFN-I signalling opened up new lytic spread between macrophages. Thus, the impact of IFN-I on viral replication was strongly cell type-dependent: epithelial infection induced little response; IFN-I largely suppressed macrophage infection; and viral evasion allowed passage through B cells despite IFN-I responses. As a result, IFN-I and its evasion promoted a switch in infection from acutely lytic in myeloid cells to chronically latent in B cells. Murine cytomegalovirus also showed a capacity to pass through IFN-I-responding cells, arguing that this is a core feature of herpesvirus host colonization. PMID:27223694

  20. A comparison of 12-gene colon cancer assay gene expression in African American and Caucasian patients with stage II colon cancer

    OpenAIRE

    Govindarajan, Rangaswamy; Posey, James; Chao, Calvin Y.; Lu, Ruixiao; Jadhav, Trafina; Javed, Ahmed Y.; Javed, Awais; Mahmoud, Fade A.; Osarogiagbon, Raymond U.; Manne, Upender

    2016-01-01

    Background African American (AA) colon cancer patients have a worse prognosis than Caucasian (CA) colon cancer patients, however, reasons for this disparity are not well understood. To determine if tumor biology might contribute to differential prognosis, we measured recurrence risk and gene expression using the Oncotype DX® Colon Cancer Assay (12-gene assay) and compared the Recurrence Score results and gene expression profiles between AA patients and CA patients with stage II colon cancer. ...

  1. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization.

    Science.gov (United States)

    Patras, Kathryn A; Wescombe, Philip A; Rösler, Berenice; Hale, John D; Tagg, John R; Doran, Kelly S

    2015-09-01

    Streptococcus agalactiae (group B streptococcus [GBS]) colonizes the rectovaginal tract in 20% to 30% of women and during pregnancy can be transmitted to the newborn, causing severe invasive disease. Current routine screening and antibiotic prophylaxis have fallen short of complete prevention of GBS transmission, and GBS remains a leading cause of neonatal infection. We have investigated the ability of Streptococcus salivarius, a predominant member of the native human oral microbiota, to control GBS colonization. Comparison of the antibacterial activities of multiple S. salivarius strains by use of a deferred-antagonism test showed that S. salivarius strain K12 exhibited the broadest spectrum of activity against GBS. K12 effectively inhibited all GBS strains tested, including disease-implicated isolates from newborns and colonizing isolates from the vaginal tract of pregnant women. Inhibition was dependent on the presence of megaplasmid pSsal-K12, which encodes the bacteriocins salivaricin A and salivaricin B; however, in coculture experiments, GBS growth was impeded by K12 independently of the megaplasmid. We also demonstrated that K12 adheres to and invades human vaginal epithelial cells at levels comparable to GBS. Inhibitory activity of K12 was examined in vivo using a mouse model of GBS vaginal colonization. Mice colonized with GBS were treated vaginally with K12. K12 administration significantly reduced GBS vaginal colonization in comparison to nontreated controls, and this effect was partially dependent on the K12 megaplasmid. Our results suggest that K12 may have potential as a preventative therapy to control GBS vaginal colonization and thereby prevent its transmission to the neonate during pregnancy. PMID:26077762

  2. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

    Directory of Open Access Journals (Sweden)

    Yashuan eChao

    2015-01-01

    Full Text Available Streptococcus pneumoniae (the pneumococcus is a common colonizer of the human nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization results in millions of infections and over 1 million deaths per year, mostly in individuals under the age of 5 and the elderly. Colonizing pneumococci form well-organized biofilm communities in the nasopharyngeal environment, but the specific role of biofilms and their interaction with the host during colonization and disease is not yet clear. Pneumococci in biofilms are highly resistant to antimicrobial agents and this phenotype can be recapitulated when pneumococci are grown on respiratory epithelial cells under conditions found in the nasopharyngeal environment. Pneumococcal biofilms display lower levels of virulence in vivo and provide an optimal environment for increased genetic exchange both in vitro and in vivo, with increased natural transformation seen during co-colonization with multiple strains. Biofilms have also been detected on mucosal surfaces during pneumonia and middle ear infection, although the role of these biofilms in the disease process is debated. Recent studies have shown that changes in the nasopharyngeal environment caused by concomitant virus infection, changes in the microflora, inflammation, or other host assaults trigger active release of pneumococci from biofilms. These dispersed bacteria have distinct phenotypic properties and transcriptional profiles different from both biofilm and broth-grown, planktonic bacteria, resulting in a significantly increased virulence in vivo.In this review we discuss the properties of pneumococcal biofilms, the role of biofilm formation during pneumococcal colonization, including their propensity for increased ability to exchange genetic material, as well as mechanisms involved in transition from asymptomatic biofilm colonization to dissemination and disease of otherwise sterile sites. Greater understanding of

  3. The Role of Recreation in Preventing Youth with Behavioral and Cognitive Disabilities from Coming into Contact with the Juvenile Justice System and Preventing Recidivism. Monograph Series on Education, Disability and Juvenile Justice.

    Science.gov (United States)

    Howard, David K.; Peniston, Lorraine C.

    This monograph, one of a series on youth with disabilities and the juvenile justice system, focuses on the role of recreation in preventing juvenile delinquency and recidivism among youth with disabilities. Section 1 addresses factors involved in being at-risk for juvenile delinquency. These include exclusion from recreation activities, limited…

  4. Patterns and Prevalence of School Access, Transitions and Equity in South Africa: Secondary Analyses of BT20 Large-Scale Data Sources. CREATE Pathways to Access. Research Monograph No. 27

    Science.gov (United States)

    Fleisch, Brahm; Shindler, Jennifer

    2009-01-01

    This monograph looks at patterns and prevalence of initial school enrolment, late entry, attainment promotion, and repetition in urban South Africa. The paper pays special attention to the particular gender nature of the patterns of school participation. The study analyses data generated in the genuine representative cohort study, Birth-to-Twenty…

  5. COLON SPECIFIC DRUG DELIVERY SYSTEMS: A REVIEW ON PHARMACEUTICAL APPROACHES WITH CURRENT TRENDS

    Directory of Open Access Journals (Sweden)

    Komaragiri Keerthi

    2012-07-01

    Full Text Available In recent years colon specific drug delivery has gained importance not just for the delivery of drugs for the treatment of local diseases associated with the colon but also as potential site for the systemic delivery of drugs like therapeutic proteins and peptides. This article reviews a detailed study about diseases of colon, diagnosis of diseases of colon, limitations and challenges, applications, anatomy of colon, factors affecting colon and different approaches of colon which include some current new approaches such as Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Multiparticulate system, Enterion capsule technology and some past studies of colon drug delivery and also a study on evaluation for site specific drug delivery to colon.

  6. Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer

    Directory of Open Access Journals (Sweden)

    McDougall Gordon

    2007-01-01

    Full Text Available Abstract Background There is a probable association between consumption of fruit and vegetables and reduced risk of cancer, particularly cancer of the digestive tract. This anti-cancer activity has been attributed in part to anti-oxidants present in these foods. Raspberries in particular are a rich source of the anti-oxidant compounds, such as polyphenols, anthocyanins and ellagitannins. Methods A "colon-available" raspberry extract (CARE was prepared that contained phytochemicals surviving a digestion procedure that mimicked the physiochemical conditions of the upper gastrointestinal tract. The polyphenolic-rich extract was assessed for anti-cancer properties in a series of in vitro systems that model important stages of colon carcinogenesis, initiation, promotion and invasion. Results The phytochemical composition of CARE was monitored using liquid chromatography mass spectrometry. The colon-available raspberry extract was reduced in anthocyanins and ellagitannins compared to the original raspberry juice but enriched in other polyphenols and polyphenol breakdown products that were more stable to gastrointestinal digestion. Initiation – CARE caused significant protective effects against DNA damage induced by hydrogen peroxide in HT29 colon cancer cells measured using single cell microgelelectrophoresis. Promotion – CARE significantly decreased the population of HT29 cells in the G1 phase of the cell cycle, effectively reducing the number of cells entering the cell cycle. However, CARE had no effect on epithelial integrity (barrier function assessed by recording the trans-epithelial resistance (TER of CACO-2 cell monolayers. Invasion – CARE caused significant inhibition of HT115 colon cancer cell invasion using the matrigel invasion assay. Conclusion The results indicate that raspberry phytochemicals likely to reach the colon are capable of inhibiting several important stages in colon carcinogenesis in vitro.

  7. 3D Reconstruction of virtual colon structures from colonoscopy images.

    Science.gov (United States)

    Hong, DongHo; Tavanapong, Wallapak; Wong, Johnny; Oh, JungHwan; de Groen, Piet C

    2014-01-01

    This paper presents the first fully automated reconstruction technique of 3D virtual colon segments from individual colonoscopy images. It is the basis of new software applications that may offer great benefits for improving quality of care for colonoscopy patients. For example, a 3D map of the areas inspected and uninspected during colonoscopy can be shown on request of the endoscopist during the procedure. The endoscopist may revisit the suggested uninspected areas to reduce the chance of missing polyps that reside in these areas. The percentage of the colon surface seen by the endoscopist can be used as a coarse objective indicator of the quality of the procedure. The derived virtual colon models can be stored for post-procedure training of new endoscopists to teach navigation techniques that result in a higher level of procedure quality. Our technique does not require a prior CT scan of the colon or any global positioning device. Our experiments on endoscopy images of an Olympus synthetic colon model reveal encouraging results with small average reconstruction errors (4.1 mm for the fold depths and 12.1 mm for the fold circumferences). PMID:24225230

  8. Planning for assisted colonization of plants in a warming world

    Science.gov (United States)

    Ferrarini, Alessandro; Selvaggi, Alberto; Abeli, Thomas; Alatalo, Juha M.; Orsenigo, Simone; Gentili, Rodolfo; Rossi, Graziano

    2016-06-01

    Assisted colonization is one way of facilitating range shifts for species that are restricted in their ability to move in response to climate change. Here we conceptualize and apply a new decision framework for modelling assisted colonization of plant species prior to in situ realization. Three questions were examined: a) Is species translocation useful in a certain area? b) where, and c) how long will it be successful in the future? Applying our framework to Carex foetida in Italy at the core of its distribution and its southern edge revealed that assisted colonization could be successful in short-term (2010–2039) climate conditions, partially in medium (2040–2069) but not in long-term (2070–2099) scenarios. We show that, for some species, it is likely that assisted colonization would be successful in some portions of the recipient site under current and short-term climate conditions, but over the mid- and long-term, climate changes will make species translocation unsuccessful. The proposed decision framework can help identify species that will need different conservation actions (seed banks and/or botanical gardens) when assisted colonization is unlikely to be successful. Furthermore it has broad applicability, as it can support planning of assisted migration in mountainous areas in the face of climate change.

  9. Important aspects of the colonization of central venous catheter.

    Science.gov (United States)

    Andreoli-Pinto, T J; Graziano, K U

    1999-01-01

    This study comprises five different kind of venous central catheters, 103 in total, made of Polyurethane Tecoflex, Polyurethane Vialon, PTFE and PVC, and the influence of their raw material on the microbial colonization. Patients age and sex, besides their clinical conditions, were taken into account, and neither considered as a sample vicious, nor associated with colonization. When the tips of the catheters were asseptically inoculated in Tryptic Soy Broth and Tioglicolate, colonization was detected in 15.5% of the catheters. Coagulase negative Staphylococcus, some of which with biofilm, were the predominant organisms found, although some bacillus have also been detected: Enterobacter aerogenes, Hafnia alvei, Pseudomonas cepacia, Xanthomonas maltophilia and Aeromonas sobria. It was not possible to notice any association between the colonization of the catheters and their raw material, probably due to the influence of a previous contact and linking with blood components. This contact causes a thin coating on the surface of the cathether, which makes all the catheters similar in respect of the attachment of a bacterial cell. So, the colonization depends on the virulence of the organism, much more then on the nature of the catheter. PMID:10326311

  10. [Rectoscopy and Hemoccult II in irritable colon. A prospective study].

    Science.gov (United States)

    Hovendal, C P; Kronborg, O; Hem, J; Grinsted, P; Fenger, C

    1990-09-17

    It was investigated whether Hemoccult-II test (H-II) could reduce the number of colonic examinations in patients with the irritable bowel syndrome, with normal rigid proctoscopic findings. A negative H-II was obtained in 299 patients from general practice and a positive test in nine. Colonoscopy was done in 157 and double contrast barium enema in 142 after random allocation. The nine patients with positive H-II all had colonoscopy. Among the 299 with negative H-II, colonic adenomas were detected in ten and an early cancer in an adenoma in the sigmoid colon; overlooked rectal adenomas were found in three, rectal cancer in one, rectal carcinoid in another and a coecal cancer, which could be palpated, in a third patient. Two patients with colonic cancer and one with adenoma were detected among those with positive H-II. All patients were followed by clinical examination after one year. In conclusion, colonic examination should carry a low priority in patients with symptoms of irritable bowel, negative Hemoccult-II and normal rigid proctoscopic findings performed by an experienced examiner. The investigation confirmed the recommendation of total colonoscopy in patients with a positive H-II and added support for increasing number of endoscopy services in contrast to those of diagnostic radiology, which should be reduced. PMID:2219505

  11. Piroxicam decreases postirradiation colonic neoplasia in the rat

    Energy Technology Data Exchange (ETDEWEB)

    Northway, M.G.; Scobey, M.W.; Cassidy, K.T.; Geisinger, K.R. (Wake Forest Univ., Winston Salem, NC (USA))

    1990-12-01

    This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation. 41 references.

  12. Planning for assisted colonization of plants in a warming world.

    Science.gov (United States)

    Ferrarini, Alessandro; Selvaggi, Alberto; Abeli, Thomas; Alatalo, Juha M; Orsenigo, Simone; Gentili, Rodolfo; Rossi, Graziano

    2016-01-01

    Assisted colonization is one way of facilitating range shifts for species that are restricted in their ability to move in response to climate change. Here we conceptualize and apply a new decision framework for modelling assisted colonization of plant species prior to in situ realization. Three questions were examined: a) Is species translocation useful in a certain area? b) where, and c) how long will it be successful in the future? Applying our framework to Carex foetida in Italy at the core of its distribution and its southern edge revealed that assisted colonization could be successful in short-term (2010-2039) climate conditions, partially in medium (2040-2069) but not in long-term (2070-2099) scenarios. We show that, for some species, it is likely that assisted colonization would be successful in some portions of the recipient site under current and short-term climate conditions, but over the mid- and long-term, climate changes will make species translocation unsuccessful. The proposed decision framework can help identify species that will need different conservation actions (seed banks and/or botanical gardens) when assisted colonization is unlikely to be successful. Furthermore it has broad applicability, as it can support planning of assisted migration in mountainous areas in the face of climate change. PMID:27345374

  13. Spasmolytic effect of Vitis vinifera leaf extract on rat colon

    Directory of Open Access Journals (Sweden)

    Gharib Naseri M.K.

    2006-07-01

    Full Text Available Vitis vinifera (grape leaf has been used traditionally to treat diarrhea and its extract induces relaxation in rat aorta and uterus. The aim of present study was to investigate the effect of grape leaf hydroalcoholic extract (GLHE on rat colon contractions induced by some spasmogens. A piece of distal colon from male adult Wistar rats were dissected and mounted in an organ bath containing Tyrode solution and colon contractions recorded by an isotonic transducer under 1g resting tension. The GLHE (0.5- 4 mg/ml reduced the contractions induced by KCl (60 mM, BaCl2 (4 mM, acetylcholine (1 μM dose-dependently (P<0.001. The spasmolytic effect of GLHE on ACh-induced contraction was unaffected by propranolol (1 μM, phentolamine (1 μM, L-NAME (300 μM, and naloxone (1μM. In Ca2+-free but rich in KCl (120 mM Tyrode solution, cumulative concentrations of CaCl2 induced colon contractions which, were inhibited by the extract. Glibenclamide (3 μM had no effect on the extract spasmolytic activity, but tetraethylammonium (5 mM contracted the pre-relaxed colon induced by the extract. Results suggest that the grape leaf hydroalcoholic extract spasmolytic effect is due to the blockade of the voltage dependent calcium channels and activation of Ca2+-operated potassium channels

  14. Role of colonic microbiota in colorectal carcinogenesis: a systematic review

    Directory of Open Access Journals (Sweden)

    Marta Borges-Canha

    2015-11-01

    Full Text Available Background and aim: The human colonic mucosa is populated by a wide range of microorganisms, usually in a symbiotic relation with the host. Sometimes this balance is lost and a state of dysbiosis arises, exposing the colon to different metabolic and inflammatory stimuli (according to the microbiota's changing profile. Recent findings lead to hypothesize that this unbalance may create a subclinical pro-inflammatory state that increases DNA mutations and, therefore, colorectal carcinogenesis. In this article we aim to systematically review the scientific evidence regarding colonic microbiota and its role in colorectal carcinogenesis. Methods: Systematic review of PubMed searching results for original articles studying microbiota and colorectal cancer until November 2014. Results: Thirty-one original articles studied the role of colon microbiota in colorectal carcinoma including both human and animal studies. Different and heterogeneous methods were used and different bacteria were considered. Nevertheless, some bacteria are consistently augmented (such as Fusobacteria, Alistipes, Porphyromonadaceae, Coriobacteridae, Staphylococcaceae, Akkermansia spp. and Methanobacteriales, while other are constantly diminished in colorectal cancer (such as Bifidobacterium, Lactobacillus, Ruminococcus, Faecalibacterium spp., Roseburia, and Treponema. Moreover, bacteria metabolites amino acids are increased and butyrate is decreased throughout colonic carcinogenesis. Conclusion: Conclusive evidence shows that colorectal carcinogenesis is associated with microbial dysbiosis. This information may be used to create new prophylactic, diagnostic and therapeutic strategies for colorectal cancer.

  15. Sucrose and IQ induced mutations in rat colon by independent

    DEFF Research Database (Denmark)

    Hansen, Max; Hald, M. T.; Autrup, H.;

    2004-01-01

    Sucrose-rich diets have repeatedly been observed to have co-carcinogenic actions in colon and liver of rats and to increase the number of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induced aberrant crypt foci in rat colon. To investigate a possible interaction between sucrose and IQ on the...... genotoxicity in rat liver and colon, we gave Big Blue rats(TM) a diet containing sucrose (0%, 3.45% or 13.4% w/w) and/or IQ (70 ppm) for a period of 3 weeks. Sucrose and IQ increased the mutation frequency in the colon. The effect of combined treatments with IQ and sucrose on the mutation frequencies was...... additive indicating that sucrose and IQ act independently. This was supported by the mutation spectra where sucrose expands the background mutations in the colon, whereas IQ, in other studies, more specifically has induced G:C --> T:A transversions. In the liver IQ increased the mutation frequency, whereas...

  16. Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver

    Science.gov (United States)

    2016-01-22

    Liver Metastases; Mucinous Adenocarcinoma of the Colon; Mucinous Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Signet Ring Adenocarcinoma of the Colon; Signet Ring Adenocarcinoma of the Rectum; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer

  17. Cell surface glycopeptides from human intestinal epithelial cell lines derived from normal colon and colon adenocarcinomas

    International Nuclear Information System (INIS)

    The cell surface glycopeptides from an epithelial cell line (CCL 239) derived from normal human colon were compared with those from three cell lines (HCT-8R, HCT-15, and CaCo-2) derived independently from human colonic adenocarcinomas. Cells were incubated with D-[2-3H]mannose or L-[5,6-3H]fucose for 24 h and treated with trypsin to release cell surface components which were then digested exhaustively with Pronase and fractionated on Bio-Gel P-6 before and after treatment with endo-beta-N-acetylglucosaminidase H. The most noticeable difference between the labeled glycopeptides from the tumor and CCL 239 cells was the presence in the former of an endo-beta-N-acetylglucosaminidase H-resistant high molecular weight glycopeptide fraction which was eluted in the void volume of Bio-Gel P-6. This fraction was obtained with both labeled mannose and fucose as precursors. However, acid hydrolysis of this fraction obtained after incubation with [2-3H]mannose revealed that as much as 60-90% of the radioactivity was recovered as fucose. Analysis of the total glycopeptides (cell surface and cell pellet) obtained after incubation with [2-3H]mannose showed that from 40-45% of the radioactivity in the tumor cells and less than 10% of the radioactivity in the CCL 239 cells was recovered as fucose. After incubation of the HCT-8R cells with D-[1,6-3H]glucosamine and L-[1-14C]fucose, strong acid hydrolysis of the labeled glycopeptide fraction excluded from Bio-Gel P-6 produced 3H-labeled N-acetylglucosamine and N-acetylgalactosamine

  18. Freud's private mini-monograph on his own dreams. A contribution to the celebration of the centenary of The interpretation of dreams.

    Science.gov (United States)

    Blum, H P

    2001-10-01

    A virtually unknown brief commentary by Freud on the characteristics of his own dreams is described and discussed. Freud's mini-monograph, discovered after some 80 years, has autobiographical, theoretical and organisational significance in the enigmatic context of the early development of psychoanalysis. Found among papers of Alfred Adler, this extraordinary document adds to our knowledge of psychoanalytic history, including the significance of dreams in the evolution of psychoanalytic thought. Freud's commentary permitted the identification of a particular dream as his own. This dream had been presented in anonymity to the fledgling Vienna Psychoanalytic Society for interpretation. The dream was later inserted, again anonymously, into The Interpretation of Dreams with Freud's own remarkable pre-oedipal interpretation. Freud's conflicted relationships with Adler and Jung are considered in historical context. PMID:11723960

  19. 清代中前期饮食专著的编撰研究%On the Diet Monographs of the Early and Middle Qing Dynasty

    Institute of Scientific and Technical Information of China (English)

    孙铁楠

    2012-01-01

    饮食是人类赖以生存发展的重要因素。如何解决好饮食问题,涉及到社会的政治、经济、文化等多方面的内容。我国很早就有关于饮食方面的书籍,清代中前期饮食文献是我国古代饮食文献发展的最高阶段,它不仅对前代饮食进行了总结,使饮食文献内容更加丰富,而且对近现代饮食文献的发展和完善也产生积极的作用。在数目众多的清代饮食文献中,饮食专著文献不仅是清代饮食文献的主体,而且最能体现这一时期所取得的成就。目前学术界对于清代中前期饮食专著文献的研究是比较薄弱的。专门对清代中前期饮食文献方面的研究,虽然有对于某一本著作进行研究的论文,但是缺少从总体上进行分析探讨。因此,从历史文献学角度研究清代中前期饮食专著文献是十分必要的。%Diet is an important factor in the survival and development of human beings. How to have a healthy diet involves many aspects including politics, economy, and culture. China had books on diet quite long time ago. The early and middle period of Qing Dynasty reached the highest stage of development of China's ancient diet literature, which not only summarized the previous generations' diet literature, but also enriched their contents and had a positive effect on the development of modern diet literature. Diet monographs account for a crucial part among the numerous culinary literatures in Qing Dynasty, and they can best embody the achievements of this period. However, the study of diet monographs of the early and middle period of Qing Dynasty is relatively weak. Although there are papers researching on some of those monographs, overall analysis and discussion are insufficient. Therefore, it is very necessary to study the diet monographs of the early and middle period of Qing Dynasty from the point of historical literature view.

  20. 浅议海洋科技专著中地图的规范化%Map Standardization in Marine Technology Monograph

    Institute of Scientific and Technical Information of China (English)

    白燕; 彭珺

    2014-01-01

    The existing problems of maps are discussed and analyzed. It is believed that maps should meet the requirements of self -evident, abstract and simplistic. As for the map name, line graphs, and image maps, the suggestions of map standardization are proposed to improve maps' information transfer functions and visual effects in marine technology monographs.%讨论分析了目前海洋科技专著中地图所存在的问题,提出了地图应符合自明性、抽象性和简明性的要求,并针对图名、线划图和影像图提出地图制作的规范化建议,以便增强地图在海洋科技专著中的信息传递功能和视觉效果。

  1. RDA描述的不同:以普通图书为例%Differences of RDA Cataloging: Focus on Monograph

    Institute of Scientific and Technical Information of China (English)

    王忠红

    2012-01-01

    以普通图书为重点,论述RDA著录的不同。文章先概述RDA基本理念和条例组织,然后以著录项目为序,逐项说明其不同之处,包括著录信息来源、著录方式以及检索点的获取。稍议RDA的利弊以及对编目馆员工作和OPAC的影响。%This paper discusses differences of RDA cataloging from AACR2 with a focus on monograph. It first discusses the RDA rules, and then the differences in description areas. It covers differences in sources of information, transcription and choosing of access points. In the end, discusses its impact on the cataloging work and OPAC, and makes a conclusion.

  2. Clostridium septicum aortitis with associated sigmoid colon adenocarcinoma.

    Science.gov (United States)

    Ge, Phillip S; de Virgilio, Christian

    2012-02-01

    We report an unusual case of Clostridium septicum aortitis with associated adenocarcinoma of the sigmoid colon. An 87-year-old man with multiple medical comorbidities presented with a 1-week history of severe abdominal pain in the left lower quadrant of his abdomen. Abdominal computed tomography showed, in addition to a mass in the sigmoid colon, a gas density within the wall of the abdominal aorta with extensive periaortic fat stranding and some additional gas densities in the proximal left common iliac artery. The patient refused surgery, and was treated with intravenous antibiotics. He died 5 weeks later. The development of Clostridiumsepticum aortitis, an extremely rare but life-threatening infection, is highly associated with an underlying colonic malignancy and demands immediate surgical intervention. PMID:22304871

  3. Tubular colonic duplication - review of 1876-1981 literature

    International Nuclear Information System (INIS)

    Four cases of tubular colonic duplication are reported and 53 more are reviewed from 1876-1981 literature. Eighty percent of these patients had other anomalies, most notably genital and bladder duplications. Females outnumbered the males 37 to 20. Fifty percent of patients of either sex had some form of fistulous communication. In no one was the anomaly incompatible with life. Based on the anatomy of distal ends of duplicated colon, the patients are divided in five groups, for each of which the incidence and nature of concomitant anomalies are tabulated. Because of their anatomic complexity, most patients with colonic duplication require clinical evaluation by multiple subspecialists. We have also suggested the sequence and extent to which they should be evaluated by radiologists. (orig.)

  4. Colonization by Streptococcus agalactiae during pregnancy: maternal and perinatal prognosis

    Directory of Open Access Journals (Sweden)

    Patrícia El Beitune

    2005-08-01

    Full Text Available We reviewed colonization by group B Streptococcus beta-haemolyticus of Lancefield (SGB, or Streptococcus agalactiae, in pregnant women, and the consequences of infection for the mother and newborn infant, including factors that influence the risk for anogenital colonization by SGB. We also examined the methods for diagnosis and prophylaxis of SGB to prevent early-onset invasive neonatal bacterial disease. At present, it is justifiable to adopt anal and vaginal SGB culture as part of differentiated obstetrical care in order to reduce early neonatal infection. The rates, risk factors of maternal and neonatal SGB colonization, as well as the incidence of neonatal disease, may vary in different communities and need to be thoroughly evaluated in each country to allow the most appropriate preventive strategy to be selected.

  5. Transfer of blood urea into the goat colon

    International Nuclear Information System (INIS)

    Transfer of body urea into the temporarily isolated and perfused colon of conscious goats was measured. Simultaneously total urea turnover was estimated using 14C-urea. The transfer of urea into the total gastrointestinal tract (total turnover minus renal excretion) was four times higher with the high-energy - low-protein diet (sugar pulp plus straw) compared with control feeding (hay ad lib.). The transfer of urea into the colon was 8% of the transfer into the total GI tract during control feeding, 14% when food was withheld for 48 hours and 1% during sugar pulp feeding. The transfer into the colon depends mainly on the plasma urea concentration, whereas in the proximal part of the GI tract changes in the permeability of the GI tract wall have a more pronounced influence than plasma urea concentration. (author)

  6. Scintigraphic assessment of gastric emptying, small bowel and colonic transit

    International Nuclear Information System (INIS)

    This paper describes a simplified scintigraphy method of whole gut transit measurement proposed by Camilleri et al. Two tracers are used: 111In-labelled Amberlite beads for colonic motility study and 99mTc-labelled beads for gastric emptying evaluation. The 111In-labelled beads are placed in a capsule given to the patient at time T2, which disintegrates in the distal ileon or proximal colon in order to release the radiopharmaceutical at the beginning of the colon. The 99mTc-labelled beads are incorporated in a omelette served to the patient at T0 and are used to measure gastric emptying and small bowel transit. Static anterior and posterior views are obtained at different times (T0, T2, T4 and ring the different transit times. (authors). 241 refs., 2 figs., 1 tab

  7. Helminth infection promotes colonization resistance via type 2 immunity.

    Science.gov (United States)

    Ramanan, Deepshika; Bowcutt, Rowann; Lee, Soo Ching; Tang, Mei San; Kurtz, Zachary D; Ding, Yi; Honda, Kenya; Gause, William C; Blaser, Martin J; Bonneau, Richard A; Lim, Yvonne A L; Loke, P'ng; Cadwell, Ken

    2016-04-29

    Increasing incidence of inflammatory bowel diseases, such as Crohn's disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we show that individuals from helminth-endemic regions harbor a similar protective microbiota and that deworming treatment reduced levels of Clostridiales and increased Bacteroidales. These results support a model of the hygiene hypothesis in which certain individuals are genetically susceptible to the consequences of a changing microbial environment. PMID:27080105

  8. A case of leptospirosis simulating colon cancer with liver metastases

    Institute of Scientific and Technical Information of China (English)

    Alessandro Granito; Giorgio Ballardini; Marco Fusconi; Umberto Volta; Paolo Muratori; Vittorio Sambri; Giuseppe Battista; Francesco B. Bianchi

    2004-01-01

    We report a case of a 61-year-old man who presented with fatigue, abdominal pain and hepatomegaly. Computed tomography (CT) of the abdomen showed hepatomegaly and multiple hepatic lesions highly suggestive of metastatic diseases. Due to the endoscopic finding of colon ulcer, colon cancer with liver metastases was suspected. Biochemically a slight increase of transaminases, alkaline phosphatase and gammaglutamyl transpeptidase were present; α-fetoprotein, carcinoembryogenic antigen and carbohydrate 19-9 antigen serum levels were normal. Laboratory and instrumental investigations, including colon and liver biopsies revealed no signs of malignancy. In the light of spontaneous improvement of symptoms and CT findings, his personal history was revaluated revealing direct contact with pigs and their tissues. Diagnosis of leptospirosis was considered and confirmed by detection of an elevated titer of antibodies to leptospira. After two mo, biochemical data, CT and colonoscopy were totally normal.

  9. Clostridium septicum Sepsis and Colon Carcinoma: Report of 4 Cases

    Directory of Open Access Journals (Sweden)

    Eric Mao

    2011-01-01

    Full Text Available An association exists between colon carcinoma and Clostridium septicum infection, especially bacteremia. We reviewed retrospectively all positive blood cultures for this organism at a 300-bed general hospital over 4 years. Four of 15 cases were associated with concurrent colon carcinoma. C. septicum infection was the presenting feature of previously undiagnosed large bowel malignancy in three patients. We report this small case series to alert clinicians to the diverse spectrum and diagnostic difficulties of this rare, potentially catastrophic association. Although commonly associated with necrotizing skin or soft tissue infections, this bacterium can present with nonspecific or atypical symptoms. All patients with positive blood cultures for C. septicum, even without clinical suspicion of large bowel malignancy, should undergo colonoscopy to evaluate for colon carcinoma.

  10. Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.

    Science.gov (United States)

    Carroll, Siobhan Yvonne; O'Mahony, Siobhain Mary; Grenham, Susan; Cryan, John Francis; Hyland, Niall Patrick

    2013-01-01

    The interface between psychiatry and stress-related gastrointestinal disorders (GI), such as irritable bowel syndrome (IBS), is well established, with anxiety and depression the most frequently occurring comorbid conditions. Moreover, stress-sensitive Wistar Kyoto (WKY) rats, which display anxiety- and depressive-like behaviors, exhibit GI disturbances akin to those observed in stress-related GI disorders. Additionally, there is mounting preclinical and clinical evidence implicating mast cells as significant contributors to the development of abdominal visceral pain in IBS. In this study we examined the effects of the rat connective tissue mast cell (CTMC) stabiliser, disodium cromoglycate (DSCG) on visceral hypersensitivity and colonic ion transport, and examined both colonic and peritoneal mast cells from stress-sensitive WKY rats. DSCG significantly decreased abdominal pain behaviors induced by colorectal distension in WKY animals independent of a reduction in colonic rat mast cell mediator release. We further demonstrated that mast cell-stimulated colonic ion transport was sensitive to inhibition by the mast cell stabiliser DSCG, an effect only observed in stress-sensitive rats. Moreover, CTMC-like mast cells were significantly increased in the colonic submucosa of WKY animals, and we observed a significant increase in the proportion of intermediate, or immature, peritoneal mast cells relative to control animals. Collectively our data further support a role for mast cells in the pathogenesis of stress-related GI disorders. PMID:24367692

  11. Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.

    Directory of Open Access Journals (Sweden)

    Siobhan Yvonne Carroll

    Full Text Available The interface between psychiatry and stress-related gastrointestinal disorders (GI, such as irritable bowel syndrome (IBS, is well established, with anxiety and depression the most frequently occurring comorbid conditions. Moreover, stress-sensitive Wistar Kyoto (WKY rats, which display anxiety- and depressive-like behaviors, exhibit GI disturbances akin to those observed in stress-related GI disorders. Additionally, there is mounting preclinical and clinical evidence implicating mast cells as significant contributors to the development of abdominal visceral pain in IBS. In this study we examined the effects of the rat connective tissue mast cell (CTMC stabiliser, disodium cromoglycate (DSCG on visceral hypersensitivity and colonic ion transport, and examined both colonic and peritoneal mast cells from stress-sensitive WKY rats. DSCG significantly decreased abdominal pain behaviors induced by colorectal distension in WKY animals independent of a reduction in colonic rat mast cell mediator release. We further demonstrated that mast cell-stimulated colonic ion transport was sensitive to inhibition by the mast cell stabiliser DSCG, an effect only observed in stress-sensitive rats. Moreover, CTMC-like mast cells were significantly increased in the colonic submucosa of WKY animals, and we observed a significant increase in the proportion of intermediate, or immature, peritoneal mast cells relative to control animals. Collectively our data further support a role for mast cells in the pathogenesis of stress-related GI disorders.

  12. Variability of spectra of laser-induced fluorescence of colonic mucosa: its significance for fluorescence detection of colonic neoplasia.

    Science.gov (United States)

    Chwirot, Barbara W; Kowalska, Małgorzata; Płóciennik, Natalia; Piwiński, Mariusz; Michniewicz, Zbigniew; Chwirot, Stanisław

    2003-05-01

    To determine the extent of a natural variability of the spectra of the autofluorescence and its significance for a reproducibility of different approaches typically used in studies on fluorescence detection of colonic lesions. Two independent series of experiments have been conducted during three years in the same laboratory. Macroscopic tissue specimens obtained during operations of patients with colonic cancers were studied in vitro. The tissues were excited using UV lines of c.w. He-Cd laser and pulsed nitrogen laser and the autofluorescence spectra were recorded for areas visually diagnosed as normal or pathologically changed mucosa. Natural variability of the autofluorescence spectra of colonic tissues seems to be most important factor limiting sensitivity and specificity of the diagnostic algorithms. The mean fluorescence spectra obtained for normal mucosa and its neoplastic lesions differ significantly but the differences are difficult to observe because of the high natural variability among the individual spectra. Further studies of biological basis of the colonic autofluorescence are necessary for a progress in the field of fluorescence detection of colonic neoplastic lesions. PMID:15244272

  13. Novel aspects of cholinergic regulation of colonic ion transport.

    Science.gov (United States)

    Bader, Sandra; Diener, Martin

    2015-06-01

    Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across colonic epithelium. Ussing chamber experiments with putative nicotinic agonists and antagonists were performed at rat colon combined with reverse transcription polymerase chain reaction (RT-PCR) detection of nicotinic receptor subunits within the epithelium. Dimethylphenylpiperazinium (DMPP) and nicotine induced a tetrodotoxin-resistant anion secretion leading to an increase in short-circuit current (I sc) across colonic mucosa. The response was suppressed by the nicotinic receptor antagonist hexamethonium. RT-PCR experiments revealed the expression of α2, α4, α5, α6, α7, α10, and β4 nicotinic receptor subunits in colonic epithelium. Choline, the product of acetylcholine hydrolysis, is known for its affinity to several nicotinic receptor subtypes. As a strong acetylcholinesterase activity was found in colonic epithelium, the effect of choline on I sc was examined. Choline induced a concentration-dependent, tetrodotoxin-resistant chloride secretion which was, however, resistant against hexamethonium, but was inhibited by atropine. Experiments with inhibitors of muscarinic M1 and M3 receptors revealed that choline-evoked secretion was mainly due to a stimulation of epithelial M3 receptors. Although choline proved to be only a partial agonist, it concentration-dependently desensitized the response to acetylcholine, suggesting that it might act as a modulator of cholinergically induced anion secretion. Thus the cholinergic regulation of colonic ion transport - up to now solely explained by cholinergic submucosal neurons stimulating epithelial muscarinic receptors - is more complex than previously assumed. PMID:26236483

  14. A clinical pathway to accelerate recovery after colonic resection

    DEFF Research Database (Denmark)

    Basse, L; Hjort Jakobsen, D; Billesbølle, P; Werner, M; Kehlet, H

    2000-01-01

    -induced organ dysfunction, paralytic ileus, pain, and fatigue. It has been hypothesized that an accelerated multimodal rehabilitation program with optimal pain relief, stress reduction with regional anesthesia, early enteral nutrition, and early mobilization may enhance recovery and reduce the complication rate......OBJECTIVE: To investigate the feasibility of a 48-hour postoperative stay program after colonic resection. SUMMARY BACKGROUND DATA: Postoperative hospital stay after colonic resection is usually 6 to 12 days, with a complication rate of 10% to 20%. Limiting factors for early recovery include stress...

  15. Inflammatory polyps in idiopathic inflammation of the colon

    Energy Technology Data Exchange (ETDEWEB)

    Winter, J.; Schupp, R.R.; Friedrich, M.

    1983-02-01

    The article discusses the morphology and clinical importance of inflammatory polyps. It is shown via an analysis of the authors' own patients that no importance can be attached to such lesions in the differential diagnosis of indiopathic inflammations of the colon: 52,7% of the patients with Crohn's colitis (n = 112) as well as 43.3% of the patients with Colitis ulcerosa (n = 67) showed inflammatory polyps of the colon in the course of their disease. The article discusses the difficulty of radiological differentiation against adenomas or premalignant dysplasias of chronically inflamed mucosa.

  16. Laparoscopic removal of an intrauterine device from the sigmoid colon

    OpenAIRE

    Şanlıkan, Fatih; Arslan, Oğuz; Avcı, Muhittin Eftal; Göçmen, Ahmet

    2015-01-01

    Uterine wall perforation which is commonly seen through the posterior wall of the uterus is the most serious complication of an intrauterine device (IUD). We present a case of laparoscopic removal of an IUD from the sigmoid colon in a 31-years-old female who was admitted to hospital with a history of pelvic pain and abnormal vaginal bleeding for one month. The dislocated IUD was removed from the sigmoid colon of laparoscopic intervention without any complications. In conclusion, the treatment...

  17. Survival after elective surgery for colonic cancer in Denmark

    DEFF Research Database (Denmark)

    Perdawid, S K; Hemmingsen, L; Boesby, S;

    2012-01-01

    AIM: Total mesorectal excision (TME) has been shown to improve the outcome for patients with rectal cancer. In contrast, there are fewer data on complete mesocolic excision (CME) for colonic cancer. METHOD: Data from the National Colorectal Cancer Database were analysed. This includes about 95% of...... included for the final analysis. The overall 5-year survival rates were 0.65 in 2001-2004 and 0.66 in 2005-2008. The relative 5-year survival rates were also within 1% of each other. None of these comparisons was statistically significant. CONCLUSION: Survival following elective colon cancer surgery has...

  18. Locally advanced transverse colon cancer with Trousseau’s syndrome

    Directory of Open Access Journals (Sweden)

    V. A. Aliyev

    2015-02-01

    Full Text Available Migratory venous thrombosis is a manifestation of the rare paraneoplastic syndrome in patients with malignant neoplasms. The paper describes successful surgical treatment in a young patient with a colon tumor associated with Trousseau’s syndrome. The latter manifesting itself as ischemia forced urgent surgeons to amputate the lower third of the left leg. Locally advanced transverse colon cancer spreading to the great vessels was subsequently diagnosed. All paraneoplastic manifestations disappeared after tumor removal. The patient was professionally given surgical, anesthesiological, and resuscitative aids that not only improved his quality of life, but also gave the chance to prolong it.

  19. Hyaluronic acid regulates normal intestinal and colonic growth in mice

    OpenAIRE

    Riehl, Terrence E.; Ee, Xueping; Stenson, William F

    2012-01-01

    Hyaluronic acid (HA), a component of the extracellular matrix, affects gastrointestinal epithelial proliferation in injury models, but its role in normal growth is unknown. We sought to determine the effects of exogenous HA on intestinal and colonic growth by intraperitoneal injection of HA twice a week into C57BL/6 mice from 3 to 8 wk of age. Similarly, to determine the effects of endogenous HA on intestinal and colonic growth, we administered PEP-1, a peptide that blocks the binding of HA t...

  20. Variables associated with cognitive impairment in patients with colon cancer

    OpenAIRE

    López-Santiago, Sonia; Cruzado, Juan Antonio; Custodio, Ana Belén; Feliu Batlle, Jaime

    2011-01-01

    Objetivo: Identificar las variables predictoras de menor rendimiento cognitivo en pacientes de cáncer de colon tratados con cirugía que esperan recibir quimioterapia. Método: En una muestra de 89 pacientes de cáncer de colon se valoró la relación entre su rendimiento en tres dominios cognitivos (función ejecutiva, memoria verbal y habilidad psicomotora) y las siguientes variables: edad, sexo, años de escolaridad, estadio, pronóstico médico, comorbilidad, hemoglobina, ansiedad, depresión, a...