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Sample records for axonal velocity distributions

  1. Focal axonal swellings and associated ultrastructural changes attenuate conduction velocity in central nervous system axons: a computer modeling study.

    Science.gov (United States)

    Kolaric, Katarina V; Thomson, Gemma; Edgar, Julia M; Brown, Angus M

    2013-08-01

    The constancy of action potential conduction in the central nervous system (CNS) relies on uniform axon diameter coupled with fidelity of the overlying myelin providing high-resistance, low capacitance insulation. Whereas the effects of demyelination on conduction have been extensively studied/modeled, equivalent studies on the repercussions for conduction of axon swelling, a common early pathological feature of (potentially reversible) axonal injury, are lacking. The recent description of experimentally acquired morphological and electrical properties of small CNS axons and oligodendrocytes prompted us to incorporate these data into a computer model, with the aim of simulating the effects of focal axon swelling on action potential conduction. A single swelling on an otherwise intact axon, as occurs in optic nerve axons of Cnp1 null mice caused a small decrease in conduction velocity. The presence of single swellings on multiple contiguous internodal regions (INR), as likely occurs in advanced disease, caused qualitatively similar results, except the dimensions of the swellings required to produce equivalent attenuation of conduction were significantly decreased. Our simulations of the consequences of metabolic insult to axons, namely, the appearance of multiple swollen regions, accompanied by perturbation of overlying myelin and increased axolemmal permeability, contained within a single INR, revealed that conduction block occurred when the dimensions of the simulated swellings were within the limits of those measured experimentally, suggesting that multiple swellings on a single axon could contribute to axonal dysfunction, and that increased axolemmal permeability is the decisive factor that promotes conduction block. PMID:24303138

  2. Changes in the axonal conduction velocity of pyramidal tract neurons in the aged cat.

    Science.gov (United States)

    Xi, M C; Liu, R H; Engelhardt, J K; Morales, F R; Chase, M H

    1999-01-01

    The present study was undertaken to determine whether age-dependent changes in axonal conduction velocity occur in pyramidal tract neurons. A total of 260 and 254 pyramidal tract neurons were recorded extracellularly in the motor cortex of adult control and aged cats, respectively. These cells were activated antidromically by electrical stimulation of the medullary pyramidal tract. Fast- and slow-conducting neurons were identified according to their axonal conduction velocity in both control and aged cats. While 51% of pyramidal tract neurons recorded in the control cats were fast conducting (conduction velocity greater than 20 m/s), only 26% of pyramidal tract neurons in the aged cats were fast conducting. There was a 43% decrease in the median conduction velocity for the entire population of pyramidal tract neurons in aged cats when compared with that of pyramidal tract neurons in the control cats (P cats. However, the regression slope was significantly reduced in aged cats. This reduction was due to the appearance of a group of pyramidal tract neurons with relatively shorter spike durations but slower axonal conduction velocities in the aged cat. Sample intracellular data confirmed the above results. These observations form the basis for the following conclusions: (i) there is a decrease in median conduction velocity of pyramidal tract neurons in aged cats; (ii) the reduction in the axonal conduction velocity of pyramidal tract neurons in aged cats is due, in part, to fibers that previously belonged to the fast-conducting group and now conduct at slower velocity. PMID:10392844

  3. White matter microstructure from nonparametric axon diameter distribution mapping.

    Science.gov (United States)

    Benjamini, Dan; Komlosh, Michal E; Holtzclaw, Lynne A; Nevo, Uri; Basser, Peter J

    2016-07-15

    We report the development of a double diffusion encoding (DDE) MRI method to estimate and map the axon diameter distribution (ADD) within an imaging volume. A variety of biological processes, ranging from development to disease and trauma, may lead to changes in the ADD in the central and peripheral nervous systems. Unlike previously proposed methods, this ADD experimental design and estimation framework employs a more general, nonparametric approach, without a priori assumptions about the underlying form of the ADD, making it suitable to analyze abnormal tissue. In the current study, this framework was used on an ex vivo ferret spinal cord, while emphasizing the way in which the ADD can be weighted by either the number or the volume of the axons. The different weightings, which result in different spatial contrasts, were considered throughout this work. DDE data were analyzed to derive spatially resolved maps of average axon diameter, ADD variance, and extra-axonal volume fraction, along with a novel sub-micron restricted structures map. The morphological information contained in these maps was then used to segment white matter into distinct domains by using a proposed k-means clustering algorithm with spatial contiguity and left-right symmetry constraints, resulting in identifiable white matter tracks. The method was validated by comparing histological measures to the estimated ADDs using a quantitative similarity metric, resulting in good agreement. With further acquisition acceleration and experimental parameters adjustments, this ADD estimation framework could be first used preclinically, and eventually clinically, enabling a wide range of neuroimaging applications for improved understanding of neurodegenerative pathologies and assessing microstructural changes resulting from trauma. PMID:27126002

  4. Focal axonal swellings and associated ultrastructural changes attenuate conduction velocity in central nervous system axons: a computer modeling study

    OpenAIRE

    Kolaric, Katarina V; Thomson, Gemma; Edgar, Julia M; Brown, Angus M.

    2013-01-01

    The constancy of action potential conduction in the central nervous system (CNS) relies on uniform axon diameter coupled with fidelity of the overlying myelin providing high-resistance, low capacitance insulation. Whereas the effects of demyelination on conduction have been extensively studied/modeled, equivalent studies on the repercussions for conduction of axon swelling, a common early pathological feature of (potentially reversible) axonal injury, are lacking. The recent description of ex...

  5. The Velocity Distribution of Hypervelocity Stars

    CERN Document Server

    Rossi, Elena M; Sari, Re'em

    2013-01-01

    We consider the process of stellar binaries tidally disrupted by a supermassive black hole. For highly eccentric orbits, as one star is ejected from the three-body system, the companion remains bound to the black hole. Hypervelocity stars (HVSs) observed in the Galactic halo and S-stars observed orbiting the central black hole may originate from such mechanism. In this paper, we predict the velocity distribution of the ejected stars of a given mass, after they have travelled out of the Galactic potential. We use both analytical methods and Monte Carlo simulations. We find that each part of the velocity distribution encodes different information. At low velocities < 800 km/s, the Galactic Potential shapes universally the observed distribution, which rises towards a peak, related to the Galactic escape velocity. Beyond the peak, the velocity distribution depends on binary mass and separation distributions. Finally, the finite star life introduces a break related to their mass. A qualitative comparison of our...

  6. Directional Dark Matter Search and Velocity Distribution

    CERN Document Server

    Nagao, Keiko I

    2014-01-01

    Directional detection of dark matter is the next generation experiment, which is expected to have better back ground rejection efficiency than conventional direct search. Another intriguing possibility of the experiment by means of the directional information is measurement the velocity distribution of dark matter. Especially, it will be potent to figure out whether the velocity distribution is anisotropic. Supposing three distribution models, we discuss the possibility in one of the directional dark matter searches, nuclear emulsion detector.

  7. Rotational velocities of A-type stars. III. Velocity distributions

    Science.gov (United States)

    Royer, F.; Zorec, J.; Gómez, A. E.

    2007-02-01

    Aims:A sample of v sin i of B9 to F2-type main sequence single stars has been built from highly homogeneous {v sin i} parameters determined for a large sample cleansed of objects presenting the Am and Ap phenomenon as well as of all known binaries. The aim is to study the distributions of rotational velocities in the mass range of A-type stars for normal single objects. Methods: Robust statistical methods are used to rectify the {v sin i} distributions for the projection effect and the error distribution. The equatorial velocity distributions are obtained for about 1100 stars divided in six groups defined by the spectral type, under the assumption of randomly orientated rotational axes. Results: We show that late B and early A-type main-sequence stars have genuine bimodal distributions of true equatorial rotational velocities probably due to angular momentum loss and redistribution that the star underwent before reaching the main sequence. A striking lack of slow rotators is noticed among intermediate and late A-type stars. Full Table [see full text] is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/463/671 Appendices are only available in electronic form at http://www.aanda.org

  8. The Velocity Distribution of Hypervelocity Stars

    Science.gov (United States)

    Rossi, Elena M.; Kobayashi, Shiho; Sari, Re'em

    2014-11-01

    We consider the process of stellar binaries tidally disrupted by a supermassive black hole (BH). For highly eccentric orbits, as one star is ejected from the three-body system, the companion remains bound to the BH. Hypervelocity stars (HVSs) observed in the Galactic halo and S-stars observed orbiting the central BH may originate from such mechanism. In this paper, we predict the velocity distribution of the ejected stars of a given mass, after they have traveled out of the Galactic potential. We use both analytical methods and Monte Carlo simulations. We find that each part of the velocity distribution encodes different information. At low velocities <800 km s-1, the Galactic potential universally shapes the observed distribution, which rises toward a peak, related to the Galactic escape velocity. Beyond the peak, the velocity distribution depends on binary mass and separation distributions. Finally, the finite star life introduces a break related to their mass. A qualitative comparison of our models with current observations shows the great potential of HVSs to constrain bulge and Galactic properties. Standard choices for parameter distributions predict velocities below and above ~800 km s-1 with equal probability, while none are observed beyond ~700 km s-1 and the current detections are more clustered at low velocities 300-400 km s-1. These features may indicate that the separation distribution of binaries that reach the tidal sphere is not flat in logarithmic space, as observed in more local massive binaries, but has more power toward larger separations, enhancing smaller velocities. In addition, the binary formation/evolution process or the injection mechanism might also induce a cut-off a min ~ 10 R ⊙ in the separation distribution.

  9. The velocity distribution of hypervelocity stars

    International Nuclear Information System (INIS)

    We consider the process of stellar binaries tidally disrupted by a supermassive black hole (BH). For highly eccentric orbits, as one star is ejected from the three-body system, the companion remains bound to the BH. Hypervelocity stars (HVSs) observed in the Galactic halo and S-stars observed orbiting the central BH may originate from such mechanism. In this paper, we predict the velocity distribution of the ejected stars of a given mass, after they have traveled out of the Galactic potential. We use both analytical methods and Monte Carlo simulations. We find that each part of the velocity distribution encodes different information. At low velocities <800 km s–1, the Galactic potential universally shapes the observed distribution, which rises toward a peak, related to the Galactic escape velocity. Beyond the peak, the velocity distribution depends on binary mass and separation distributions. Finally, the finite star life introduces a break related to their mass. A qualitative comparison of our models with current observations shows the great potential of HVSs to constrain bulge and Galactic properties. Standard choices for parameter distributions predict velocities below and above ∼800 km s–1 with equal probability, while none are observed beyond ∼700 km s–1 and the current detections are more clustered at low velocities 300-400 km s–1. These features may indicate that the separation distribution of binaries that reach the tidal sphere is not flat in logarithmic space, as observed in more local massive binaries, but has more power toward larger separations, enhancing smaller velocities. In addition, the binary formation/evolution process or the injection mechanism might also induce a cut-off a min ∼ 10 R ☉ in the separation distribution.

  10. Velocity distribution in active particles systems

    Science.gov (United States)

    Marconi, Umberto Marini Bettolo; Gnan, Nicoletta; Paoluzzi, Matteo; Maggi, Claudio; di Leonardo, Roberto

    2016-03-01

    We derive an analytic expression for the distribution of velocities of multiple interacting active particles which we test by numerical simulations. In clear contrast with equilibrium we find that the velocities are coupled to positions. Our model shows that, even for two particles only, the individual velocities display a variance depending on the interparticle separation and the emergence of correlations between the velocities of the particles. When considering systems composed of many particles we find an analytic expression connecting the overall velocity variance to density, at the mean-field level, and to the pair distribution function valid in the limit of small noise correlation times. Finally we discuss the intriguing analogies and main differences between our effective free energy functional and the theoretical scenario proposed so far for phase-separating active particles.

  11. Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury.

    Science.gov (United States)

    Calvo, Margarita; Richards, Natalie; Schmid, Annina B; Barroso, Alejandro; Zhu, Lan; Ivulic, Dinka; Zhu, Ning; Anwandter, Philipp; Bhat, Manzoor A; Court, Felipe A; McMahon, Stephen B; Bennett, David L H

    2016-01-01

    Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were hardly detectable in the naïve state, showed increased expression within juxtaparanodes and paranodes following injury, both in rats and humans. Within the dorsal root (a site remote from injury) we noted a redistribution of Kv1-channels towards the paranode. Blockade of Kv1 channels with α-DTX after injury reinstated hyperexcitability of A-fibre axons and enhanced mechanosensitivity. Changes in the molecular composition and distribution of axonal Kv1 channels, therefore represents a protective mechanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury. PMID:27033551

  12. Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque.

    Science.gov (United States)

    Liewald, Daniel; Miller, Robert; Logothetis, Nikos; Wagner, Hans-Joachim; Schüz, Almut

    2014-10-01

    The aim of this study was to obtain information on the axonal diameters of cortico-cortical fibres in the human brain, connecting distant regions of the same hemisphere via the white matter. Samples for electron microscopy were taken from the region of the superior longitudinal fascicle and from the transitional white matter between temporal and frontal lobe where the uncinate and inferior occipitofrontal fascicle merge. We measured the inner diameter of cross sections of myelinated axons. For comparison with data from the literature on the human corpus callosum, we also took samples from that region. For comparison with well-fixed material, we also included samples from corresponding regions of a monkey brain (Macaca mulatta). Fibre diameters in human brains ranged from 0.16 to 9 μm. Distributions of diameters were similar in the three systems of cortico-cortical fibres investigated, both in humans and the monkey, with most of the average values below 1 μm diameter and a small population of much thicker fibres. Within individual human brains, the averages were larger in the superior longitudinal fascicle than in the transitional zone between temporal and frontal lobe. An asymmetry between left and right could be found in one of the human brains, as well as in the monkey brain. A correlation was also found between the thickness of the myelin sheath and the inner axon diameter for axons whose calibre was greater than about 0.6 μm. The results are compared to white matter data in other mammals and are discussed with respect to conduction velocity, brain size, cognition, as well as diffusion weighted imaging studies. PMID:25142940

  13. The Velocity Distribution of Isolated Radio Pulsars

    Science.gov (United States)

    Arzoumanian, Z.; Chernoff, D. F.; Cordes, J. M.; White, Nicholas E. (Technical Monitor)

    2002-01-01

    We infer the velocity distribution of radio pulsars based on large-scale 0.4 GHz pulsar surveys. We do so by modelling evolution of the locations, velocities, spins, and radio luminosities of pulsars; calculating pulsed flux according to a beaming model and random orientation angles of spin and beam; applying selection effects of pulsar surveys; and comparing model distributions of measurable pulsar properties with survey data using a likelihood function. The surveys analyzed have well-defined characteristics and cover approx. 95% of the sky. We maximize the likelihood in a 6-dimensional space of observables P, dot-P, DM, absolute value of b, mu, F (period, period derivative, dispersion measure, Galactic latitude, proper motion, and flux density). The models we test are described by 12 parameters that characterize a population's birth rate, luminosity, shutoff of radio emission, birth locations, and birth velocities. We infer that the radio beam luminosity (i) is comparable to the energy flux of relativistic particles in models for spin-driven magnetospheres, signifying that radio emission losses reach nearly 100% for the oldest pulsars; and (ii) scales approximately as E(exp 1/2) which, in magnetosphere models, is proportional to the voltage drop available for acceleration of particles. We find that a two-component velocity distribution with characteristic velocities of 90 km/ s and 500 km/ s is greatly preferred to any one-component distribution; this preference is largely immune to variations in other population parameters, such as the luminosity or distance scale, or the assumed spin-down law. We explore some consequences of the preferred birth velocity distribution: (1) roughly 50% of pulsars in the solar neighborhood will escape the Galaxy, while approx. 15% have velocities greater than 1000 km/ s (2) observational bias against high velocity pulsars is relatively unimportant for surveys that reach high Galactic absolute value of z distances, but is severe for

  14. Anomalous velocity distributions in active Brownian suspensions

    OpenAIRE

    Fiege, Andrea; Vollmayr-Lee, Benjamin; Zippelius, Annette

    2013-01-01

    Large scale simulations and analytical theory have been combined to obtain the non-equilibrium velocity distribution, $f(v)$, of randomly accelerated particles in suspension. The simulations are based on an event-driven algorithm, generalised to include friction. They reveal strongly anomalous but largely universal distributions which are independent of volume fraction and collision processes, which suggests a one-particle model should capture all the essential features. We have formulated th...

  15. Electron velocity distributions near collisionless shocks

    International Nuclear Information System (INIS)

    Recent studies of the amount of electron heating and of the shapes of electron velocity distributions across shocks near the earth are reviewed. It is found that electron heating increases with increasing shock strength but is always less than the ion heating. The scale length of electron heating is also less than that for the ions. Electron velocity distributions show characteristic shapes which depend on the strength of the shocks. At the weaker shocks, electron heating is mostly perpendicular to the ambient magnetic field, bar B, and results in Gaussian-shaped velocity distributions at low-to-moderate energies. At the stronger shocks, parallel heating predominates resulting in flat-topped velocity distributions. A reasonable interpretation of these results indicates that at the weaker shocks electron heating is dominated by a tendency toward conservation of the magnetic moment. At the stronger fast-mode shocks, this heating is thought to be dominated by an acceleration parallel to bar B produced by the macroscopic shock electric field followed by beam driven plasma instabilities. Some contribution to the heating at the stronger shocks from conservation of the magnetic moment and cross-field current-driven instabilities cannot be ruled out. Although the heating at slow-mode shocks is also dominated by instabilities driven by magnetic field-aligned electron beams, their acceleration mechanism is not yet established

  16. Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons.

    Science.gov (United States)

    Kress, Geraldine J; Dowling, Margaret J; Eisenman, Lawrence N; Mennerick, Steven

    2010-04-01

    Intrinsic excitability is a key feature dictating neuronal response to synaptic input. Here we investigate the recent observation that dentate granule neurons exhibit a more depolarized voltage threshold for action potential initiation than CA3 pyramidal neurons. We find no evidence that tonic GABA currents, leak or voltage-gated potassium conductances, or the expression of sodium channel isoform differences can explain this depolarized threshold. Axonal initial segment voltage-gated sodium channels, which are dominated by the Na(V)1.6 isoform in both cell types, distribute more proximally and exhibit lower overall density in granule neurons than in CA3 neurons. To test possible contributions of sodium channel distributions to voltage threshold and to test whether morphological differences participate, we performed simulations of dentate granule neurons and of CA3 pyramidal neurons. These simulations revealed that cell morphology and sodium channel distribution combine to yield the characteristic granule neuron action potential upswing and voltage threshold. Proximal axon sodium channel distribution strongly contributes to the higher voltage threshold of dentate granule neurons for two reasons. First, action potential initiation closer to the somatodendritic current sink causes the threshold of the initiating axon compartment to rise. Second, the proximity of the action potential initiation site to the recording site causes somatic recordings to more faithfully reflect the depolarized threshold of the axon than in cells like CA3 neurons, with distally initiating action potentials. Our results suggest that the proximal location of axon sodium channels in dentate granule neurons contributes to the intrinsic excitability differences between DG and CA3 neurons and may participate in the low-pass filtering function of dentate granule neurons. PMID:19603521

  17. On the geocentric micrometeor velocity distribution

    Science.gov (United States)

    Janches, Diego; Nolan, Michael C.; Meisel, David D.; Mathews, John D.; Zhou, Qihou H.; Moser, Danielle E.

    2003-06-01

    We report micrometeor velocity distributions measured with unprecedented velocity and radiant resolution using the dual-beam 430 MHz Arecibo (AO) radar in Puerto Rico. The AO radar detects over 10,000 events daily inside its 300 m radar beam that are produced mainly by particles in the size range 0.5-100 microns. During the observations reported here, the line feed antenna is pointed vertically while the Gregorian feed is pointed at an angle of 15 degrees from zenith. The off-vertical radar beam is initially placed pointing north and every 30 min is rotated 180 degrees, allowing observation of three different regions of the Earth's ionosphere. Results from the observations performed on 21 January and 25 June 2002 are presented and discussed. We observe that the meteoroid population detected by AO is smaller in particle size and faster in velocity and thus entirely different from the one observed by conventional lower-frequency meteor radars that use a different scattering mechanism. We observe qualitative difference in the shape of the meteor velocity distribution for the different pointing directions. Preliminary analysis of these distributions indicates that we detect at least four particle populations characterized by their geocentric velocities: A slow one with a "classical" value (˜15 km/sec), an intermediate velocity population (˜30 km/sec) the presence of which depends on ecliptic latitude and longitude, and two fast and dominant (at sunrise) populations (˜45 km/sec and ˜50 km/sec). Finally, we explore the possibility of observational biases in our technique and find no evidence for large effects.

  18. Single-point velocity distribution in turbulence

    CERN Document Server

    Falkovich, G; Falkovich, Gregory; Lebedev, Vladimir

    1997-01-01

    We show that the tails of the single-point velocity probability distribution function (PDF) are generally non-Gaussian in developed turbulence. By using instanton formalism for the Navier-Stokes equation, we establish the relation between the PDF tails of the velocity and those of the external forcing. In particular, we show that a Gaussian random force having correlation scale $L$ and correlation time $\\tau$ produces velocity PDF tails $\\ln{\\cal P}(v)\\propto-v^4$ at $v\\gg v_{rms}, L/\\tau$. For a short-correlated forcing when $\\tau\\ll L/v_{rms}$ there is an intermediate asymptotics $\\ln {\\cal P}(v)\\propto-v^3$ at $L/\\tau\\gg v\\gg v_{rms}$.

  19. Anomalous velocity distributions in active Brownian suspensions.

    Science.gov (United States)

    Fiege, Andrea; Vollmayr-Lee, Benjamin; Zippelius, Annette

    2013-08-01

    Large-scale simulations and analytical theory have been combined to obtain the nonequilibrium velocity distribution, f(v), of randomly accelerated particles in suspension. The simulations are based on an event-driven algorithm, generalized to include friction. They reveal strongly anomalous but largely universal distributions, which are independent of volume fraction and collision processes, which suggests a one-particle model should capture all the essential features. We have formulated this one-particle model and solved it analytically in the limit of strong damping, where we find that f(v) decays as 1/v for multiple decades, eventually crossing over to a Gaussian decay for the largest velocities. Many particle simulations and numerical solution of the one-particle model agree for all values of the damping. PMID:24032806

  20. Velocity and velocity-difference distributions in Burgers turbulence

    OpenAIRE

    Boldyrev, S.; Linde, T.; Polyakov, A.

    2003-01-01

    We consider the one-dimensional Burgers equation randomly stirred at large scales by a Gaussian short-time correlated force. Using the method of dissipative anomalies, we obtain velocity and velocity-difference probability density functions and confirm the results with high-resolution numerical simulations.

  1. Velocity Distributions & Density Fluctuations in a 2D Granular Gas

    OpenAIRE

    Olafsen, J. S.; Urbach, J. S.

    1999-01-01

    Velocity distributions in a vibrated granular monolayer are investigated experimentally. Non-Gaussian velocity distributions are observed at low vibration amplitudes but cross over smoothly to Gaussian distributions as the amplitude is increased. Cross-correlations between fluctuations in density and temperature are present only when the velocity distributions are strongly non-Gaussian. Confining the expansion of the granular layer results in non-Gaussian velocity distributions that persist t...

  2. Velocity distribution in recoil-distance Doppler-shift experiments

    International Nuclear Information System (INIS)

    The Recoil-Distance Doppler-Shift (RDDS) technique is a well established method to measure lifetimes of excited nuclear states in the pico-second range. In standard RDDS experiments at non-relativistc beam-energies, the velocities of the emerging recoils are usually distributed narrowly around a mean velocity v = left angle v right angle v. Under these circumstances, the effect of the velocity distribution is neglectable and the assumption that all nuclei move with the average velocity is justified. In this poster we investigate the influence of broader velocity distributions on lifetimes determined using the standard lifetime analysis-method DDCM. This can be observed, e.g., in experiments with thick targets. In particular, it is shown that the effect of the velocity distribution on the deduced lifetime is minimised at the maximum amplitude of the derivative of the decay function.

  3. Velocity distributions in vertically vibrated granular media

    OpenAIRE

    Delour, J.; Kudrolli, A.; Gollub, J. P.

    1998-01-01

    This paper has been withdrawn by the authors. It has been superceded by an improved investigation: "Velocity statistics in vibrated granular media" W. Losert, D.G.W. Cooper, J. Delour, A. Kudrolli, and J.P. Gollub (submitted to Chaos for a special issue on Granular Materials) cond-mat/9901203

  4. Experimental investigation of particle velocity distributions in windblown sand movement

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    With the PDPA(Phase Doppler Particle Analyzer) measurement technology,the probability distributions of particle impact and lift-off velocities on bed surface and the particle velocity distributions at different heights are detected in a wind tunnel. The results show that the probability distribution of impact and lift-off velocities of sand grains can be expressed by a log-normal function,and that of impact and lift-off angles complies with an exponential function. The mean impact angle is between 28° and 39°,and the mean lift-off angle ranges from 30° to 44°. The mean lift-off velocity is 0.81-0.9 times the mean impact velocity. The proportion of backward-impacting particles is 0.05-0.11,and that of backward-entrained particles ranges from 0.04 to 0.13. The probability distribution of particle horizontal velocity at 4 mm height is positive skew,the horizontal velocity of particles at 20 mm height varies widely,and the variation of the particle horizontal velocity at 80 mm height is less than that at 20 mm height. The probability distribution of particle vertical velocity at different heights can be described as a normal function.

  5. Quantitative velocity distributions via nuclear magnetic resonance flow metering

    Science.gov (United States)

    O'Neill, Keelan T.; Fridjonsson, Einar O.; Stanwix, Paul L.; Johns, Michael L.

    2016-08-01

    We demonstrate the use of Tikhonov regularisation as a data inversion technique to determine the velocity distributions of flowing liquid streams. Regularisation is applied to the signal produced by a nuclear magnetic resonance (NMR) flow measurement system consisting of a pre-polarising permanent magnet located upstream of an Earth's magnetic field NMR detection coil. A simple free induction decay (FID) NMR signal is measured for the flowing stream in what is effectively a 'time-of-flight' measurement. The FID signal is then modelled as a function of fluid velocity and acquisition time, enabling determination of the velocity probability distributions via regularisation. The mean values of these velocity distributions were successfully validated against in-line rotameters. The ability to quantify multi-modal velocity distributions was also demonstrated using a two-pipe system.

  6. Velocity distribution and pressure loss at three-dimensional roughnesses

    International Nuclear Information System (INIS)

    Measurements of the pressure drop and the velocity distribution at three-dimensional roughnesses in a rectangular channel of variable channel width were performed with air. The friction factors of the extreme roughness (p/h = 2.5, g/e = 1) were found to be the highest which were measured up to now. The velocity distribution showed great differences to that observed at other roughnesses. The 'law of the wall' is not adequate to describe the velocity profile over these roughnesses, the velocity profiles are much flatter. (orig.)

  7. Universal non-Gaussian velocity distribution in violent gravitational processes

    Science.gov (United States)

    Iguchi, Osamu; Sota, Yasuhide; Tatekawa, Takayuki; Nakamichi, Akika; Morikawa, Masahiro

    2005-01-01

    We study the velocity distribution in spherical collapses and cluster-pair collisions by use of N -body simulations. Reflecting the violent gravitational processes, the velocity distribution of the resultant quasistationary state generally becomes non-Gaussian. Through the strong mixing of the violent process, there appears a universal non-Gaussian velocity distribution, which is a democratic (equal-weighted) superposition of many Gaussian distributions (DT distribution). This is deeply related with the local virial equilibrium and the linear mass-temperature relation which characterize the system. We show the robustness of this distribution function against various initial conditions which leads to the violent gravitational process. The DT distribution has a positive correlation with the energy fluctuation of the system. On the other hand, the coherent motion such as the radial motion in the spherical collapse and the rotation with the angular momentum suppress the appearance of the DT distribution.

  8. Behaviour of ion velocity distributions for a simple collision model

    Science.gov (United States)

    St-Maurice, J.-P.; Schunk, R. W.

    1974-01-01

    Calculation of the ion velocity distributions for a weakly ionized plasma subjected to crossed electric and magnetic fields. An exact solution to Boltzmann's equation has been obtained by replacing the Boltzmann collision integral with a simple relaxation model. At altitudes above about 150 km, where the ion collision frequency is much less than the ion cyclotron frequency, the ion distribution takes the shape of a torus in velocity space for electric fields greater than 40 mV/m. This shape persists for one to two hours after application of the electric field. At altitudes where the ion collision and cyclotron frequencies are approximately equal (about 120 km), the ion velocity distribution is shaped like a bean for large electric field strengths. This bean-shaped distribution persists throughout the lifetime of ionospheric electric fields. These highly non-Maxwellian ion velocity distributions may have an appreciable affect on the interpretation of ion temperature measurements.

  9. How Required Reserve Ratio Affects Distribution and Velocity of Money

    CERN Document Server

    Xi, N; Wang, Y; Xi, Ning; Ding, Ning; Wang, Yougui

    2005-01-01

    In this paper the dependence of wealth distribution and the velocity of money on the required reserve ratio is examined based on a random transfer model of money and computer simulations. A fractional reserve banking system is introduced to the model where money creation can be achieved by bank loans and the monetary aggregate is determined by the monetary base and the required reserve ratio. It is shown that monetary wealth follows asymmetric Laplace distribution and latency time of money follows exponential distribution. The expression of monetary wealth distribution and that of the velocity of money in terms of the required reserve ratio are presented in a good agreement with simulation results.

  10. The $\\Omega$ dependence of the velocity divergence distribution

    CERN Document Server

    Bernardeau, F; Hivon, E; Bouchet, F R

    1996-01-01

    We present a series of results investigating the $\\Omega$ dependence of the distribution function of the large scale local cosmic velocity divergence. Analytical studies using perturbation theory techniques indicate that the shape of this distribution should be strongly dependent on $\\Omega$. This dependence is all the more interesting as it does not involve biases of the galaxy distribution with respect to the underlying density distribution, making it a potentially promising and useful basis for new and alternative methods to obtain bias-independent estimates of $\\Omega$. After a description of the $\\Omega$ dependent characteristics expected in the shape of the velocity divergence PDF, we study this distribution on the basis of a set of $N$-body simulations. To analyze the discretely sampled velocity field yielded by the latter, we apply a set of recently developed numerical tools, the ``Voronoi'' and ``Delaunay'' methods. These two methods were devised specifically for the purpose of investigating statisti...

  11. SPIDER - IX. Classifying galaxy groups according to their velocity distribution

    Science.gov (United States)

    Ribeiro, A. L. B.; de Carvalho, R. R.; Trevisan, M.; Capelato, H. V.; La Barbera, F.; Lopes, P. A. A.; Schilling, A. C.

    2013-09-01

    We introduce a new method to study the velocity distribution of galaxy systems, the Hellinger Distance (HD), designed for detecting departures from a Gaussian velocity distribution. Testing different approaches to measure normality of a distribution, we conclude that HD is the least vulnerable method to type I and II statistical errors. We define a relaxed galactic system as the one with unimodal velocity distribution and a normality deviation below a critical value (HD ) and the Gaussianity of the velocity distribution of the groups. Bright galaxies (Mr ≤ -20.7) residing in the inner and outer regions of groups do not show significant differences in the listed quantities regardless if the group has a Gaussian (G) or a Non-Gaussian (NG) velocity distribution. However, the situation is significantly different when we examine the faint galaxies (-20.7 populations, testifying how the environment is affecting the galaxies. Instead, in NG groups there is no segregation between the properties of galaxies in the inner and outer regions, showing that the properties of these galaxies still reflect the physical processes prevailing in the environment where they were found earlier.

  12. Motion of Euglena Gracilis: Active Fluctuations and Velocity Distribution

    CERN Document Server

    Romanczuk, Pawel; Scholz, Dimitri; Lobaskin, Vladimir; Schimansky-Geier, Lutz

    2015-01-01

    We study the velocity distribution of unicellular swimming algae Euglena gracilis using optical microscopy and theory. To characterize a peculiar feature of the experimentally observed distribution at small velocities we use the concept of active fluctuations, which was recently proposed for the description of stochastically self-propelled particles [Romanczuk, P. and Schimansky-Geier, L., Phys. Rev. Lett. 106, 230601 (2011)]. In this concept, the fluctuating forces arise due to internal random performance of the propulsive motor. The fluctuating forces are directed in parallel to the heading direction, in which the propulsion acts. In the theory, we introduce the active motion via the depot model [Schweitzer et al., Phys. Rev. Lett. 80, 23, 5044 (1998)]. We demonstrate that the theoretical predictions based on the depot model with active fluctuations are consistent with the experimentally observed velocity distributions. In addition to the model with additive active noise, we obtain theoretical results for a...

  13. Self-consistent size and velocity distributions of collisional cascades

    CERN Document Server

    Pan, Margaret

    2011-01-01

    The standard theoretical treatment of collisional cascades derives a steady-state size distribution assuming a single constant velocity dispersion for all bodies regardless of size. Here we relax this assumption and solve self-consistently for the bodies' steady-state size and size-dependent velocity distributions. Specifically, we account for viscous stirring, dynamical friction, and collisional damping of the bodies' random velocities in addition to the mass conservation requirement typically applied to find the size distribution in a steady-state cascade. The resulting size distributions are significantly steeper than those derived without velocity evolution. For example, accounting self-consistently for the velocities can change the standard q=3.5 power-law index of the Dohnanyi (1969) differential size spectrum to an index as large as q=4. Similarly, for bodies held together by their own gravity, the corresponding power-law index range 2.88

  14. Power exponential velocity distributions in disordered porous media

    CERN Document Server

    Matyka, Maciej; Koza, Zbigniew

    2016-01-01

    Velocity distribution functions link the micro- and macro-level theories of fluid flow through porous media. Here we study them for the fluid absolute velocity and its longitudinal and lateral components relative to the macroscopic flow direction in a model of a random porous medium. We claim that all distributions follow the power exponential law controlled by an exponent $\\gamma$ and a shift parameter $u_0$ and examine how these parameters depend on the porosity. We find that $\\gamma$ has a universal value $1/2$ at the percolation threshold and grows with the porosity, but never exceeds 2.

  15. Modeling of free surface vortex with realistic downward velocity distribution

    International Nuclear Information System (INIS)

    A free surface vortex is considered as one of significant phenomena which may cause gas entrainment (GE) in sodium-cooled fast reactors. In our past studies, the free surface vortex is assumed to be approximated by the famous Burgers vortex model. However, the Burgers model has a simple and unreal assumption that the downward velocity component is horizontally constant, while in real the free surface vortex has the downward velocity distribution which shows large gradient in radial direction near the vortex center. In this study, a new theoretical vortex model with realistic downward velocity distribution is proposed. This model is derived from the axisymmetric Navier-Stokes equation as well as the Burgers model, but the downward velocity distribution in radial direction is considered. This function is defined to be zero at the vortex center and to approach asymptotically to zero at infinity. As the verification, the new model is applied to the evaluation of a simple vortex experiment, and shows good agreements with the experimental data in terms of the free surface shape. In addition, it is confirmed that the Burgers vortex model can gives similar results to the new vortex model when the downward velocity gradient in axial direction is calculated appropriately. (author)

  16. Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons

    OpenAIRE

    Kress, Geraldine J.; Dowling, Margaret; Eisenman, Lawrence N.; Mennerick, Steven

    2010-01-01

    Intrinsic excitability is a key feature dictating neuronal response to synaptic input. Here we investigate the recent observation that dentate granule neurons exhibit a more depolarized voltage threshold for action potential initiation than CA3 pyramidal neurons. We find no evidence that tonic GABA currents, leak or voltage-gated potassium conductances, or the expression of sodium channel isoform differences can explain this depolarized threshold. Axonal initial segment voltage-gated sodium c...

  17. Whistler Waves Driven by Anisotropic Strahl Velocity Distributions: Cluster Observations

    Science.gov (United States)

    Vinas, A.F.; Gurgiolo, C.; Nieves-Chinchilla, T.; Gary, S. P.; Goldstein, M. L.

    2010-01-01

    Observed properties of the strahl using high resolution 3D electron velocity distribution data obtained from the Cluster/PEACE experiment are used to investigate its linear stability. An automated method to isolate the strahl is used to allow its moments to be computed independent of the solar wind core+halo. Results show that the strahl can have a high temperature anisotropy (T(perpindicular)/T(parallell) approximately > 2). This anisotropy is shown to be an important free energy source for the excitation of high frequency whistler waves. The analysis suggests that the resultant whistler waves are strong enough to regulate the electron velocity distributions in the solar wind through pitch-angle scattering

  18. Distributed Velocity-Dependent Protocol for Multihop Cellular Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jagyasi Bhushan

    2009-01-01

    Full Text Available Abstract Cell phones are embedded with sensors form a Cellular Sensor Network which can be used to localize a moving event. The inherent mobility of the application and of the cell phone users warrants distributed structure-free data aggregation and on-the-fly routing. We propose a Distributed Velocity-Dependent (DVD protocol to localize a moving event using a Multihop Cellular Sensor Network (MCSN. DVD is based on a novel form of connectivity determined by the waiting time of nodes for a Random Waypoint (RWP distribution of cell phone users. This paper analyzes the time-stationary and spatial distribution of the proposed waiting time to explain the superior event localization and delay performances of DVD over the existing Randomized Waiting (RW protocol. A sensitivity analysis is also performed to compare the performance of DVD with RW and the existing Centralized approach.

  19. Distributed Velocity-Dependent Protocol for Multihop Cellular Sensor Networks

    Directory of Open Access Journals (Sweden)

    Deepthi Chander

    2009-01-01

    Full Text Available Cell phones are embedded with sensors form a Cellular Sensor Network which can be used to localize a moving event. The inherent mobility of the application and of the cell phone users warrants distributed structure-free data aggregation and on-the-fly routing. We propose a Distributed Velocity-Dependent (DVD protocol to localize a moving event using a Multihop Cellular Sensor Network (MCSN. DVD is based on a novel form of connectivity determined by the waiting time of nodes for a Random Waypoint (RWP distribution of cell phone users. This paper analyzes the time-stationary and spatial distribution of the proposed waiting time to explain the superior event localization and delay performances of DVD over the existing Randomized Waiting (RW protocol. A sensitivity analysis is also performed to compare the performance of DVD with RW and the existing Centralized approach.

  20. Discretising the velocity distribution for directional dark matter experiments

    International Nuclear Information System (INIS)

    Dark matter (DM) direct detection experiments which are directionally-sensitive may be the only method of probing the full velocity distribution function (VDF) of the Galactic DM halo. We present an angular basis for the DM VDF which can be used to parametrise the distribution in order to mitigate astrophysical uncertainties in future directional experiments and extract information about the DM halo. This basis consists of discretising the VDF in a series of angular bins, with the VDF being only a function of the DM speed v within each bin. In contrast to other methods, such as spherical harmonic expansions, the use of this basis allows us to guarantee that the resulting VDF is everywhere positive and therefore physical. We present a recipe for calculating the event rates corresponding to the discrete VDF for an arbitrary number of angular bins N and investigate the discretisation error which is introduced in this way. For smooth, Standard Halo Model-like distribution functions, only N=3 angular bins are required to achieve an accuracy of around 10–30% in the number of events in each bin. Shortly after confirmation of the DM origin of the signal with around 50 events, this accuracy should be sufficient to allow the discretised velocity distribution to be employed reliably. For more extreme VDFs (such as streams), the discretisation error is typically much larger, but can be improved with increasing N. This method paves the way towards an astrophysics-independent analysis framework for the directional detection of dark matter

  1. Study on velocity distribution in a pool by submersible mixers

    International Nuclear Information System (INIS)

    To study the distribution of submersible mixers and agitating effect in the sewage treatment pool, Pro/E software was utilized to build the three-dimensional model. Then, the large-scale computational fluid dynamics software FLUENT6.3 was used. ICEM software was used to build unstructured grid of sewage treatment pool. After that, the sewage treatment pool was numerically simulated by dynamic coordinate system technology and RNG k-ε turbulent model and PIOS algorithm. The macro fluid field and each section velocity flow field distribution were analyzed to observe the efficiency of each submersible mixer. The average velocity and mixing area in the sewage pool were studied simultaneously. Results show that: the preferred project B, two submersible mixers speed is 980 r/min, and setting angles are all 30°. Fluid mixing area in the pool has reached more than 95%. Under the action of two mixers, the fluid in the sewage pool form a continuous circulating water flow. The fluid is mixed adequately and average velocity of fluid in the pool is at around 0.241m/s, which agreed with the work requirements. Consequently it can provide a reference basis for practical engineering application of submersible mixers by using this method.

  2. Mechanism of proton anisotropic velocity distribution in the solar wind

    Institute of Scientific and Technical Information of China (English)

    敖先志; 沈迹; 涂传诒

    2003-01-01

    Although it has been long that spacecraft observed the anisotropy of velocity protons in the solar wind, there is still not a reasonable explanation. In this paper we try to give an explanation from the diffusion plateau of protoncyclotron resonance predicted by the quasi-linear theory for the resonance between the protons and the parallel propagating waves. We consider the effect of dispersion relation on diffusion plateau and notice that the diffusion plateau we have got by using cold plasma dispersion relation accords with the density contours in the velocity phase space detected at 0.3 AU in fast solar wind. For explaining proton distributions obtained in the fast solar wind from 0.7 AU to 1 AU hot plasma dispersion relation should be considered. We also give a theoretical relation of proton thermal anisotropy A and plasma parameter β.

  3. Anomalous Skin Effect for Anisotropic Electron Velocity Distribution Function

    Energy Technology Data Exchange (ETDEWEB)

    Igor Kaganovich; Edward Startsev; Gennady Shvets

    2004-02-19

    The anomalous skin effect in a plasma with a highly anisotropic electron velocity distribution function (EVDF) is very different from skin effect in a plasma with the isotropic EVDF. An analytical solution was derived for the electric field penetrated into plasma with the EVDF described as a Maxwellian with two temperatures Tx >> Tz, where x is the direction along the plasma boundary and z is the direction perpendicular to the plasma boundary. The skin layer was found to consist of two distinctive regions of width of order nTx/w and nTz/w, where nTx,z/w = (Tx,z/m)1/2 is the thermal electron velocity and w is the incident wave frequency.

  4. The measurement of translocation velocity distribution profile of photosynthate in crop's transporting pathway

    International Nuclear Information System (INIS)

    The principle and the method for measuring the distribution probability of photosynthate transporting from source to pool in different velocity regions were established. The method for making the translocation velocity distribution probability pattern of photosynthate was also given. The distribution profile of photosynthate transportation velocity in cucumber and rice have been measured. The results showed: (1) the transportation velocity distribution profile of photosynthate in cucumber was similar to that in rice; (2) although the translocation velocity of photosynthate distributed from 0 to the maximum velocity, it was apparent that most of the photosynthate molecules moved at relatively high velocity. (10 figs., 5 tabs.)

  5. Experiments on friction, velocity and pressure distribution of rotating discs

    Science.gov (United States)

    Dibelius, G.; Radtke, F.; Ziemann, M.

    Frictional effects and related flow mechanisms in gaps between a housing and a rotating disk have been investigated experimentally. The rotational Reynolds number varied from 2 to 30 million, for a disk radius of 0.4 m. Different axial clearances and different radial limitations of the gaps, as well as screw heads mounted at the disk, were studied. The effect of superimposed air flow through the gaps in both centrifugal and centripetal directions on velocity field, pressure distribution, axial thrust, and frictional torque is reported.

  6. Predicted and measured velocity distribution in a model heat exchanger

    International Nuclear Information System (INIS)

    This paper presents a comparison between numerical predictions, using the porous media concept, and measurements of the two-dimensional isothermal shell-side velocity distributions in a model heat exchanger. Computations and measurements were done with and without tubes present in the model. The effect of tube-to-baffle leakage was also investigated. The comparison was made to validate certain porous media concepts used in a computer code being developed to predict the detailed shell-side flow in a wide range of shell-and-tube heat exchanger geometries

  7. Predicted and measured velocity distributions in a model heat exchanger

    International Nuclear Information System (INIS)

    This paper presents a comparison between numerical predictions, using the porous media concept, and measurements of the two-dimensional isothermal shell-side velocity distributions in a model heat exchanger. Computations and measurements were done with and without tubes present in the model. The effect of tube-to-baffle leakage was also investigated. The comparison was made to validate certain porous media concepts used in a computer code being developed to predict the detailed shell-side flow in a wide range of shell-and-tube heat exchanger geometries

  8. Settling-velocity specific SOC distribution on hillslopes

    Science.gov (United States)

    Hu, Yaxian; Asefaw Berhe, Asmeret; Fogel, Marilyn L.; Heckrath, Goswin J.; Kuhn, Nikolaus J.

    2016-04-01

    The net effect of soil erosion by water, as a sink or source of atmospheric CO2, is determined by the spatial (re-)distribution and stability of eroded soil organic carbon (SOC). The depositional position of eroded SOC is a function of the transport distances of soil fractions where the SOC is stored. In theory, the transport distances of soil fractions are related to their settling velocities under given flow conditions. Yet, very few field investigations have been conducted to examine the actual movement of eroded soil fractions along hillslopes, let alone the re-distribution pattern of SOC fractions. Eroding sandy soils and sediment were sampled after a series of rainfall events along a slope on a freshly seeded cropland in Jutland, Denmark. All the soil samples were fractionated into five settling classes using a settling tube apparatus. The spatial distribution of soil settling classes shows a coarsening effect immediately below the eroding slope, followed by a fining trend at the slope tail. The δ13C values of soil fractions were more positive at the footslope than on the slope shoulder or at the slope tail, suggesting enhanced decomposition rate of fresh SOC input at the footslope during or after erosion-induced transport. Overall, our results illustrate that immediate deposition of fast settling soil fractions and the associated SOC at footslopes must be appropriately accounted for in attempts to quantify the role of soil erosion in terrestrial carbon sequestration. A SOC erodibility parameter based on actual settling velocity distribution of eroded fractions is needed to better calibrate soil erosion models.

  9. Effects of Fractal Size Distributions on Velocity Distributions and Correlations of a Polydisperse Granular Gas

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhi-Yuan; ZHANG Duan-Ming

    2008-01-01

    By the Monte Carlo method,the effect of dispersion of disc size distribution on the velocity distributions and correlations of a polydisperse granular gas with fractal size distribution is investigated in the same inelasticity.The dispersion can be described by a fractal dimension D,and the smooth hard discs are engaged in a twodimensional horizontal rectangular box,colliding inelastically with each other and driven by a homogeneous heat bath.In the steady state,the tails of the velocity distribution functions rise more significantly above a Ganssian as D increases,but the non-Ganssian velocity distribution functions do not demonstrate any apparent universal form for any value of D.The spatial velocity correlations are apparently stronger with the increase of D.The perpendicular correlations are about half the parallel correlations,and the two correlations are a power-law decay function of dimensionless distance and are of a long range.Moreover,the parallel velocity correlations of postcollisional state at contact are more than twice as large as the precollisionaJ correlations,and both of them show almost linear behaviour of the fractal dimension D.

  10. Study on the velocity distribution around a bathtub vortex

    International Nuclear Information System (INIS)

    Flow field around a bathtub vortex was investigated. A finite cylindrical vessel was used for experiments. The vessel had a tangential inlet open channel at the top, and a vertical outlet pipe at the bottom center, respectively. Flow field was visualized by ink and particle tracers, and velocity distributions were obtained. Vortex profile, a radius of stagnant region, and a radius of fast downward flow region were measured simultaneously. Two major flows were observed in the vessel; one was through the central region of the vessel, and another was along the wall of vessel, i.e., the side and bottom walls. Flow through the central region was found to increase its velocity in proportion to a distance from the free surface and to form a stagnant region along the vortex center under some experimental conditions. The flow field and the vortex profile seemed to be optimized by strength of circulation and flow rates of the major flows. However, these factors depended on both the total flow rate and the outlet pipe diameter complicatedly. A new flow field model was proposed, which based on an exact solution of the Navier-Stokes equations called an expanding vortex flow. The vortex profiles analytically calculated with the new flow model showed good agreement with experimental results. Validity of the model was verified and formation of the stagnant region was analytically discussed. (author)

  11. Discretising the velocity distribution for directional dark matter experiments

    CERN Document Server

    Kavanagh, Bradley J

    2015-01-01

    Dark matter (DM) direct detection experiments which are directionally-sensitive may be the only method of probing the full velocity distribution function (VDF) of the Galactic DM halo. We present an angular basis for the DM VDF which can be used to parametrise the distribution in order to mitigate astrophysical uncertainties in future directional experiments and extract information about the DM halo. This basis consists of discretising the VDF in a series of angular bins, with the VDF being only a function of the DM speed $v$ within each bin. In contrast to other methods, such as spherical harmonic expansions, the use of this basis allows us to guarantee that the resulting VDF is everywhere positive and therefore physical. We present a recipe for calculating the event rates corresponding to the discrete VDF for an arbitrary number of angular bins $N$ and investigate the discretisation error which is introduced in this way. For smooth, Standard Halo Model-like distribution functions, only $N=3$ angular bins ar...

  12. The velocity distribution of interstellar titanium toward Zeta Persei

    Science.gov (United States)

    Hobbs, L. M.

    1979-01-01

    Observations of the interstellar 3384-A line of Ti II toward Zeta Persei are reported at a resolution of 1.4 km/s. This resolution exceeds by a factor of almost 3 that used in any previous observations of ions that are dominant stages of ionization in H I regions. Toward Zeta Per, two resolved line components of Ti II having widths generally comparable to those of the corresponding line components of trace ions K I, Ca II, and Na I are seen. For any other ions along this line of sight which have velocity distributions similar to that observed for Ti II, the critical equivalent width above which line saturation must be significant therefore does not exceed 14 mA for ultraviolet lines lying near 1200 A.

  13. Velocity distribution of interstellar titanium toward zeta Persei

    International Nuclear Information System (INIS)

    Observations of the interstellar lambda3384 line of Ti II toward zeta Persei are reported at a resolution of 1.4 km s-1. This resolution exceeds by a factor of almost 3 that used in any previous observations of ions which are dominant stages of ionization in HI regions. Toward zeta Per, two resolved line components of Ti II having widths generally comparable to those of the corresponding line components of trace ions K I, Ca II, and Na I are seen. For any other ions along this line of sight which have velocity distributions similar to that observed for Ti II, the critical equivalent width above which line saturation must be significant therefore does not exceed 14 mA, for ultraviolet lines lying near 1200 A

  14. LASER ULTRASONIC FOR MEASUREMENTS OF VELOCITY DISTRIBUTION IN PIPES

    Directory of Open Access Journals (Sweden)

    M. Navarrete

    2004-12-01

    Full Text Available The present work describes the development of a photoacoustic flowmeter with probe-beam deflection. A pulsedlaser beam produces an acoustic pulse, whose propagation is registered by its deflection effects on two cw probebeams. The acoustic pulse in a flowing fluid is produced by absorption of a laser pulse (30 ns, 1.1 mJ focused overa path flow line. The acoustic propagations, along and against the flow, are monitored by two cw probe beams. Inthe interaction, the probe beam undergoes a transient deflection that is detected by a fast response photodiode.The velocity distribution data profile of a square pipe is obtained by means of the acoustic pulse arrival timemeasured through its cross section applying the cylindrical shockwave model developed by Vlasses. The profilesdetermined with this experimental technique are compared with two turbulent pipe flow models.

  15. Submicron Plasticity: Yield Stress, Dislocation Avalanches, and Velocity Distribution

    Science.gov (United States)

    Ispánovity, Péter Dusán; Groma, István; Györgyi, Géza; Csikor, Ferenc F.; Weygand, Daniel

    2010-08-01

    The existence of a well-defined yield stress, where a macroscopic crystal begins to plastically flow, has been a basic observation in materials science. In contrast with macroscopic samples, in microcrystals the strain accumulates in random bursts, which makes controlled plastic formation difficult. Here we study by 2D and 3D simulations the plastic deformation of submicron objects under increasing stress. We show that, while the stress-strain relation of individual samples exhibits jumps, its average and mean deviation still specify a well-defined critical stress. The statistical background of this phenomenon is analyzed through the velocity distribution of dislocations, revealing a universal cubic decay and the appearance of a shoulder due to dislocation avalanches.

  16. Transition of velocity distributions in collapsing self-gravitating N-body systems

    Science.gov (United States)

    Komatsu, Nobuyoshi; Kiwata, Takahiro; Kimura, Shigeo

    2012-02-01

    By means of N-body simulations, we study the evolution of gravity-dominated systems from an early relaxation to a collapse, focusing on the velocity distributions and thermodynamic properties. To simulate the dynamical evolution, we consider self-gravitating small N-body systems enclosed in a spherical container with adiabatic or semipermeable walls. It is demonstrated that in the early relaxation process, the velocity distribution is non-Gaussian and q-Gaussian, since the system is in quasiequilibrium states (here q is the Tsallis entropic parameter). Thereafter, the velocity distribution undergoes higher non-Gaussian distributions, especially when the core forms rapidly in the collapse process; i.e., q tends to be larger than that for the quasiequilibrium state, since the velocity distribution further deviates from Gaussian. However, after the core forms sufficiently, the velocity distribution gradually relaxes toward a Gaussian-like distribution. Accordingly, the velocity distribution evolves from a non-Gaussian distribution through a higher non-Gaussian distribution to a Gaussian-like distribution; i.e., the velocity distribution does not monotonically relax toward a Gaussian-like distribution in our collapse simulations. We clearly show such a transition of the velocity distribution, based not only on the Tsallis entropic parameter but also on the ratio of velocity moments. We also find that a negative specific heat occurs in a collapse process with mass and energy loss (such as the escape of stars from globular clusters), even if the velocity distribution is Gaussian-like.

  17. Human intraretinal myelination: Axon diameters and axon/myelin thickness ratios

    Science.gov (United States)

    FitzGibbon, Thomas; Nestorovski, Zoran

    2013-01-01

    Purpose: Human intraretinal myelination of ganglion cell axons occurs in about 1% of the population. We examined myelin thickness and axon diameter in human retinal specimens containing myelinated retinal ganglion cell axons. Materials and Methods: Two eyes containing myelinated patches were prepared for electron microscopy. Two areas were examined in one retina and five in the second retina. Measurements were compared to normal retinal and optic nerve samples and the rabbit retina, which normally contains myelinated axons. Measurements were made using a graphics tablet. Results: Mean axon diameter of myelinated axons at all locations were significantly larger than unmyelinated axons (P ≤ 0.01). Myelinated axons within the patches were significantly larger than axons within the optic nerve (P < 0.01). The relationship between axon diameter/fiber diameter (the G-ratio) seen in the retinal sites differed from that in the nerve. G-ratios were higher and myelin thickness was positively correlated to axon diameter (P < 0.01) in the retina but negatively correlated to axon diameter in the nerve (P < 0.001). Conclusion: Intraretinally myelinated axons are larger than non-myelinated axons from the same population and suggests that glial cells can induce diameter changes in retinal axons that are not normally myelinated. This effect is more dramatic on intraretinal axons compared with the normal transition zone as axons enter the optic nerve and these changes are abnormal. Whether intraretinal myelin alters axonal conduction velocity or blocks axonal conduction remains to be clarified and these issues may have different clinical outcomes. PMID:24212308

  18. Axon damage and repair in multiple sclerosis.

    OpenAIRE

    Perry, V.H.; Anthony, D. C.

    1999-01-01

    It is well known that within long-standing multiple sclerosis (MS) lesions there is axonal loss but whether it is an early or late event has been more difficult to establish. The use of immunocytochemical methods that reveal axonal end-bulbs is a valuable approach to investigating acute axonal injury in human pathological material. The application of these techniques to multiple sclerosis tissue reveals evidence of axonal injury in acute lesions; the distribution of the end-bulbs in acute and...

  19. Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque

    OpenAIRE

    Liewald, Daniel; Miller, Robert; Logothetis, Nikos; Wagner, Hans-Joachim; Schüz, Almut

    2014-01-01

    The aim of this study was to obtain information on the axonal diameters of cortico-cortical fibres in the human brain, connecting distant regions of the same hemisphere via the white matter. Samples for electron microscopy were taken from the region of the superior longitudinal fascicle and from the transitional white matter between temporal and frontal lobe where the uncinate and inferior occipitofrontal fascicle merge. We measured the inner diameter of cross sections of myelinated axons. Fo...

  20. Stationary velocity distribution in an external field: a one-dimensional model

    International Nuclear Information System (INIS)

    The velocity distribution of a charged hard rod coupled to an external field and moving in a neutral equilibrium hard rod gas is studied on the basis of Boltzmann's equation. The exact stationary solution is found. Above a threshold value the field becomes effective in the high-velocity region slowing down the decay of the velocity distribution. The drift velocity and the mean kinetic energy are discussed as functions of the field

  1. Complete velocity distribution in river cross-sections measured by acoustic instruments

    Science.gov (United States)

    Cheng, R.T.; Gartner, J.W.

    2003-01-01

    To fully understand the hydraulic properties of natural rivers, velocity distribution in the river cross-section should be studied in detail. The measurement task is not straightforward because there is not an instrument that can measure the velocity distribution covering the entire cross-section. Particularly, the velocities in regions near the free surface and in the bottom boundary layer are difficult to measure, and yet the velocity properties in these regions play the most significant role in characterizing the hydraulic properties. To further characterize river hydraulics, two acoustic instruments, namely, an acoustic Doppler current profiler (ADCP), and a "BoogieDopp" (BD) were used on fixed platforms to measure the detailed velocity profiles across the river. Typically, 20 to 25 stations were used to represent a river cross-section. At each station, water velocity profiles were measured independently and/or concurrently by an ADCP and a BD. The measured velocity properties were compared and used in computation of river discharge. In a tow-tank evaluation of a BD, it has been confirmed that BD is capable of measuring water velocity at about 11 cm below the free-surface. Therefore, the surface velocity distribution across the river was extracted from the BD velocity measurements and used to compute the river discharge. These detailed velocity profiles and the composite velocity distribution were used to assess the validity of the classic theories of velocity distributions, conventional river discharge measurement methods, and for estimates of channel bottom roughness.

  2. Relative-velocity distributions for two effusive atomic beams in counterpropagating and crossed-beam geometries

    DEFF Research Database (Denmark)

    Pedersen, Jens Olaf Pepke

    2012-01-01

    Formulas are presented for calculating the relative velocity distributions in effusive, orthogonal crossed beams and in effusive, counterpropagating beams experiments, which are two important geometries for the study of collision processes between atoms. In addition formulas for the distributions...

  3. Velocity dependence of angular distributions in gas/solid--surface collisions: Relationship to the interaction potential

    Energy Technology Data Exchange (ETDEWEB)

    Brady, J.W. Jr.; Doll, J.D.; Thompson, D.L.

    1978-10-15

    The angular and velocity distributions for gas/solid-surface collisions are examined. It is shown that the envelope of the scattered phase-space distribution is quite sensitive to the gas/surface interaction potential.

  4. Empirical Study of Traffic Velocity Distribution and its Effect on VANETs Connectivity

    CERN Document Server

    Abuelenin, Sherif M

    2015-01-01

    In this article we use real traffic data to confirm that vehicle velocities follow Gaussian distribution in steady state traffic regimes (free-flow, and congestion). We also show that in the transition between free-flow and congestion, the velocity distribution is better modeled by generalized extreme value distribution (GEV). We study the effect of the different models on estimating the probability distribution of connectivity duration between vehicles in vehicular ad-hoc networks.

  5. Velocity distribution measurements in atomic beams generated using laser induced back-ablation

    CERN Document Server

    Denning, A; Lee, S; Ammonson, M; Bergeson, S D

    2008-01-01

    We present measurements of the velocity distribution of calcium atoms in an atomic beam generated using a dual-stage laser back-ablation apparatus. Distributions are measured using a velocity selective Doppler time-of-flight technique. They are Boltzmann-like with rms velocities corresponding to temperatures above the melting point for calcium. Contrary to a recent report in the literature, this method does not generate a sub-thermal atomic beam.

  6. A possible solution to the solar neutrino problem: Relativistic corrections to the Maxwellian velocity distribution

    OpenAIRE

    Liu, Jian-Miin

    2001-01-01

    The relativistic corrections to the Maxwellian velocity distribution are needed for standard solar models. Relativistic equilibrium velocity distribution, if adopted in standard solar models, will lower solar neutrino fluxes and change solar neutrino energy spectra but keep solar sound speeds. It is possibly a solution to the solar neutrino problem.

  7. Velocity Distribution of Effective Atoms in a Small Optically Pumped Cesium Beam Frequency Standard

    Institute of Scientific and Technical Information of China (English)

    CHEN Jingbiao; WANG Fengzhi; YANG Donghai; WANG YiQiu

    2001-01-01

    In this paper, the velocity distribution of effective atoms in a small optically pumped cesium beam frequency standard has been achieved from the Fourier transforms of the experimentally recorded Ramsey patterns. The result fits well with the theoretical calculation. The second order Doppler shift correction of the small cesium atomic clock is obtained from the velocity distribution of effective atoms.

  8. Sensibility to diffusivity and velocity transversal distributions on solute dispersion in wide channels

    International Nuclear Information System (INIS)

    Using a 2-D simulation model, the spreading of a passive solute is investigated varying the transversal distribution assumed for the diffusion coefficient and the velocity. Using strongly different laws, the simulation results show a larger influence on the dispersion process by the velocity distribution, while the influence of the diffusion coefficient distribution is very small, so that it is important just to catch the average value for this coefficient. Different transversal distributions of velocity produce values of maximum concentration with a scatter in the 30-40% range

  9. Non-local velocity distribution function and one-flight approximation

    International Nuclear Information System (INIS)

    The functional equation describing the collisionless particle velocity distribution function f(V) is considered in the framework of probabilistic approach. The key element of the collisionless particles description is using the waiting time distribution ψ(t). The solution of the considered functional is obtained for several model functions ψ(t) and it leads to the power form tails of the velocity distribution f(V). It is possible to adopt considered functional to the Laplace transformation form that allows us to accord 'collision' and 'collisionless' description. This Laplace form of the functional yields the Levy-Smirnov velocity distribution function with the characteristic exponent aL=1/2

  10. SPATIAL DISTRIBUTION OF THE HIGH-VELOCITY CLOUDS

    Directory of Open Access Journals (Sweden)

    C. A. Olano

    2009-01-01

    Full Text Available I developed a method to determine theoretical distances to the High-Velocity Clouds (HVCs, based on the idea that the HVCs were ejected from the Magellanic Clouds in a relatively short period of time as a consequence of the collision between the Large (LMC and Small Magellanic Clouds (SMC. The present spatial position of each HVCs was obtained by calculating its orbit with the initial condition that the each HVCs was simultaneously launched from the LMC at the time and position of the LMC-SMC encounter.

  11. Slowing of the axonal transport of neurofilament proteins during development

    International Nuclear Information System (INIS)

    We examined age-dependent changes in neurofilament transport in motor axons of the rat sciatic nerve. SDS-PAGE and gel fluorography confirmed that the distribution of labeled neurofilament triplet protein coincides with the major slow component a (SCa) wave in these neurons. The velocity of neurofilament transport was calculated on the basis of the location of the 50th percentile of radioactivity in this wave 33 days after motor neurons were labeled by the intraspinal administration of [3H]leucine and [3H]lysine. Overall, the velocity fell from 1.95 mm/day at 3 weeks of age to 1.12 mm/day at 20 weeks. Between 3 and 10 weeks, it fell at a 6-fold higher rate (0.096 mm/day/week) than between 10 and 20 weeks (0.016 mm/day/week). We also found a marked change in the shape of the slow component wave during development. It appeared to consist of several overlapping peaks moving at slightly different velocities in animals 10 weeks of age or less as compared to a single slower moving peak at 20 weeks. We propose that the velocity of slow axonal transport reflects the level of maturation of the neuron, and that the presence of several overlapping peaks of transported radioactivity in the sciatic nerve of younger animals reflects the presence of several populations of motor axons at different stages of development. We also discuss the relationship between changes in the velocity of neurofilament transport and alterations in the composition of the cytoskeleton that occur as the axon grows in caliber during postnatal development

  12. Mitochondrial Transport and Docking in Axons

    OpenAIRE

    Cai, Qian; Sheng, Zu-Hang

    2009-01-01

    Proper transport and distribution of mitochondria in axons and at synapses are critical for the normal physiology of neurons. Mitochondria in axons display distinct motility patterns and undergo saltatory and bidirectional movement, where mitochondria frequently stop, start moving again, and change direction. While approximately one-third of axonal mitochondria are mobile in mature neurons, a large proportion remains stationary. Their net movement is significantly influenced by recruitment to...

  13. AxonSeg: Open Source Software for Axon and Myelin Segmentation and Morphometric Analysis.

    Science.gov (United States)

    Zaimi, Aldo; Duval, Tanguy; Gasecka, Alicja; Côté, Daniel; Stikov, Nikola; Cohen-Adad, Julien

    2016-01-01

    Segmenting axon and myelin from microscopic images is relevant for studying the peripheral and central nervous system and for validating new MRI techniques that aim at quantifying tissue microstructure. While several software packages have been proposed, their interface is sometimes limited and/or they are designed to work with a specific modality (e.g., scanning electron microscopy (SEM) only). Here we introduce AxonSeg, which allows to perform automatic axon and myelin segmentation on histology images, and to extract relevant morphometric information, such as axon diameter distribution, axon density and the myelin g-ratio. AxonSeg includes a simple and intuitive MATLAB-based graphical user interface (GUI) and can easily be adapted to a variety of imaging modalities. The main steps of AxonSeg consist of: (i) image pre-processing; (ii) pre-segmentation of axons over a cropped image and discriminant analysis (DA) to select the best parameters based on axon shape and intensity information; (iii) automatic axon and myelin segmentation over the full image; and (iv) atlas-based statistics to extract morphometric information. Segmentation results from standard optical microscopy (OM), SEM and coherent anti-Stokes Raman scattering (CARS) microscopy are presented, along with validation against manual segmentations. Being fully-automatic after a quick manual intervention on a cropped image, we believe AxonSeg will be useful to researchers interested in large throughput histology. AxonSeg is open source and freely available at: https://github.com/neuropoly/axonseg. PMID:27594833

  14. Precision measurement of transverse velocity distribution of a strontium atomic beam

    OpenAIRE

    F. Gao; Liu, H.; P. Xu; Tian, X.; Y Wang; Ren, J; Haibin Wu; Hong Chang

    2014-01-01

    We measure the transverse velocity distribution in a thermal Sr atomic beam precisely by velocity-selective saturated fluorescence spectroscopy. The use of an ultrastable laser system and the narrow intercombination transition line of Sr atoms mean that the resolution of the measured velocity can reach 0.13 m/s, corresponding to 90$\\mu K$ in energy units. The experimental results are in very good agreement with the results of theoretical calculations. Based on the spectroscopic techniques use...

  15. Distribution of Mesenchymal Stem Cells and Effects on Neuronal Survival and Axon Regeneration after Optic Nerve Crush and Cell Therapy

    Science.gov (United States)

    Mesentier-Louro, Louise Alessandra; Zaverucha-do-Valle, Camila; da Silva-Junior, Almir Jordão; Nascimento-dos-Santos, Gabriel; Gubert, Fernanda; de Figueirêdo, Ana Beatriz Padilha; Torres, Ana Luiza; Paredes, Bruno D.; Teixeira, Camila; Tovar-Moll, Fernanda; Mendez-Otero, Rosalia; Santiago, Marcelo F.

    2014-01-01

    Bone marrow-derived cells have been used in different animal models of neurological diseases. We investigated the therapeutic potential of mesenchymal stem cells (MSC) injected into the vitreous body in a model of optic nerve injury. Adult (3–5 months old) Lister Hooded rats underwent unilateral optic nerve crush followed by injection of MSC or the vehicle into the vitreous body. Before they were injected, MSC were labeled with a fluorescent dye or with superparamagnetic iron oxide nanoparticles, which allowed us to track the cells in vivo by magnetic resonance imaging. Sixteen and 28 days after injury, the survival of retinal ganglion cells was evaluated by assessing the number of Tuj1- or Brn3a-positive cells in flat-mounted retinas, and optic nerve regeneration was investigated after anterograde labeling of the optic axons with cholera toxin B conjugated to Alexa 488. Transplanted MSC remained in the vitreous body and were found in the eye for several weeks. Cell therapy significantly increased the number of Tuj1- and Brn3a-positive cells in the retina and the number of axons distal to the crush site at 16 and 28 days after optic nerve crush, although the RGC number decreased over time. MSC therapy was associated with an increase in the FGF-2 expression in the retinal ganglion cells layer, suggesting a beneficial outcome mediated by trophic factors. Interleukin-1β expression was also increased by MSC transplantation. In summary, MSC protected RGC and stimulated axon regeneration after optic nerve crush. The long period when the transplanted cells remained in the eye may account for the effect observed. However, further studies are needed to overcome eventually undesirable consequences of MSC transplantation and to potentiate the beneficial ones in order to sustain the neuroprotective effect overtime. PMID:25347773

  16. Numerical Investigation of Developing Velocity Distributions in Open Channel Flows

    Directory of Open Access Journals (Sweden)

    Usman Ghani

    2014-04-01

    Full Text Available The velocity profiles in open channel flows start developing after entering into the channel for quite some length. All types of laboratory experiments for open channel flows are carried out in the fully developed flow regions which exist at some length downstream the inlet. In this research work an attempt has been made to investigate the impact of roughness and slope of the channel bed on the length required for establishment of fully developed flow in an open channel. A range of different roughness values along with various slopes were considered for this purpose. It was observed that an increase in roughness results in reduction of development length; and development length reduces drastically when roughness reaches to the range normally encountered in open channel flows with emergent vegetation or natural river flows. However, it was observed that the change of slope did not have any noticeable effect on development length. This work suggests that CFD (Computational Fluid Dynamics technique can be used for getting a reliable development length before performing an experimental work

  17. Numerical investigation of developing velocity distributions in open channel flows

    International Nuclear Information System (INIS)

    The velocity profiles in open channel flows start developing after entering into the channel for quite some length. All types of laboratory experiments for open channel flows are carried out in the fully developed flow regions which exist at some length downstream the inlet. In this research work an attempt has been made to investigate the impact of roughness and slope of the channel bed on the length required for establishment of fully developed flow in an open channel. A range of different roughness values along with various slopes were considered for this purpose. It was observed that an increase in roughness results in reduction of development length; and development length reduces drastically when roughness reaches to the range normally encountered in open channel flows with emergent vegetation or natural river flows. However, it was observed that the change of slope did not have any noticeable effect on development length. This work suggests that CFD (Computational Fluid Dynamics) technique can be used for getting a reliable development length before performing an experimental work. (author)

  18. CFD Simulation of Air Velocity Distribution in Occupied Livestock Buildings

    DEFF Research Database (Denmark)

    Svidt, Kjeld; Zhang, G.; Bjerg, B.

    In modem livestock buildings the design of the ventilation systems is important in order to obtain good air distribution. The use of Computational Fluid Dynamics for predicting the air flow and air quality makes it possible to include the effect of room geometry, equipment and occupants in the de...... this study laboratory measurements in a ventilated test room with "pig simulators" are compared with CFD-simulations....

  19. Time evolution of the lateral-velocity distribution for a strong-field-ionization process

    Science.gov (United States)

    Ivanov, I. A.

    2016-05-01

    We study time development of a cusp in the lateral-velocity distribution for the process of strong-field ionization. The lateral-velocity distribution is computed using an ab initio quantum mechanical procedure for the moments of time inside and after the end of the laser pulse. We show that at the moment of time corresponding to the midpoint of the laser pulse the lateral-velocity distribution is a smooth Gaussian curve, its parameters agreeing very well with the predictions of the tunelling theories. At the moment of time corresponding to the end of the pulse the lateral-velocity distribution narrows considerably, showing the initial stage of the cusp-formation process due to the Coulomb focusing effect. Following evolution of the ionized wave packet yet further in time we consider the cusp formation in detail.

  20. Effects of uneven moisture distribution on the strength of and wave velocity in concrete.

    Science.gov (United States)

    Popovics, Sandor

    2005-05-01

    Earlier findings showed that the effects of moisture (liquid or free water) in hardened concrete on its behavior, especially the lesser known effects ofuneven moisture distribution, can (a) be significant, and (b) vary from property to property. This distribution, for instance whether or not the surface layer is drier than the overall average moisture content, can be characterized by the difference between the velocity of the longitudinal wave (pulse velocity) measured in the standard through-thickness manner, and the velocity of the longitudinal wave propagating on the concrete surface. The summary of earlier findings on the effects of moisture distribution is followed by a recent investigation on pulse velocity in the special case, occurring frequently in practice, when the distribution is uneven because the liquid is concentrated in cracks in the concrete. PMID:15823317

  1. Dark matter searches employing asymmetric velocity distributions obtained via the Eddington approach

    Science.gov (United States)

    Vergados, J. D.; Moustakidis, Ch. C.; Owen, D.

    2016-08-01

    Starting from WIMP density profiles, in the framework of the Eddington approach, we obtain the energy distribution f(E) of dark matter in our vicinity. Assuming a factorizable phase space function, f(E , L) = F(E) FL(L) , we obtain the velocity dispersions and the anisotropy parameter β in terms of the parameters describing the angular momentum dependence. By employing the derived expression f(E) we construct axially symmetric WIMP velocity distributions. The obtained distributions automatically have a velocity upper bound, as a consequence of the fact that they are associated with a gravitationally bound system, and are characterized by an anisotropy parameter β. We then show how such velocity distributions can be used in determining the event rates, including modulation, both in the standard as well directional WIMP searches.

  2. Dissipation and velocity distribution at the shear-driven jamming transition

    OpenAIRE

    Olsson, Peter

    2015-01-01

    We investigate energy dissipation and the distribution of particle velocities at the jamming transition for overdamped shear-driven frictionless disks in two dimensions at zero temperature. We find that the dissipation is caused by the fastest particles and that the fraction of particles responsible for the dissipation decreases towards zero as jamming is approached. These particles belong to an algebraic tail of the velocity distribution that approaches $\\sim v^{-3}$ as jamming is approached...

  3. The nuclear fusion reaction rate based on relativistic equilibrium velocity distribution

    OpenAIRE

    Liu, Jian-Miin

    2002-01-01

    The Coulomb barrier is in general much higher than thermal energy. Nuclear fusion reactions occur only among few protons and nuclei with higher relative energies than Coulomb barrier. It is the equilibrium velocity distribution of these high-energy protons and nuclei that participates in determining the rate of nuclear fusion reactions. In the circumstance it is inappropriate to use the Maxwellian velocity distribution for calculating the nuclear fusion reaction rate. We use the relativistic ...

  4. Approximate Kelvin-Voigt Fluid Driven by an External Force Depending on Velocity with Distributed Delay

    Directory of Open Access Journals (Sweden)

    Yantao Guo

    2015-01-01

    Full Text Available We consider the approximate 3D Kelvin-Voigt fluid driven by an external force depending on velocity with distributed delay. We investigate the long time behavior of solutions to Navier-Stokes-Voigt equation with a distributed delay external force depending on the velocity of fluid on a bounded domain. By a prior estimate and a contractive function, we give a sufficient condition for the existence of pullback attractor of NSV equation.

  5. CFD Simulation of Air Velocity Distribution in Occupied Livestock Buildings

    OpenAIRE

    Svidt, Kjeld; Zhang, G.; Bjerg, B.

    1998-01-01

    In modem livestock buildings the design of the ventilation systems is important in order to obtain good air distribution. The use of Computational Fluid Dynamics for predicting the air flow and air quality makes it possible to include the effect of room geometry, equipment and occupants in the design of ventilation systems. However, it is not appropriate to include the detailed geometry of a large group of lying or standing animals affecting the air flow in the building.It is necessary to hav...

  6. Measurement of pressure distributions and velocity fields of water jet intake flow

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Eun Ho; Yoon, Sang Youl; Kwon, Seong Hoon; Chun, Ho Hwan; Kim, Mun Chan; Kim, Kyung Chun [Busan National Univ., Busan (Korea, Republic of)

    2002-07-01

    Waterjet propulsion system can avoid cavitation problem which is being arised conventional propeller propulsion system. The main issue of designing waterjet system is the boundary layer separation at ramp and lib of water inlet. The flow characteristics are highly depended on Jet to Velocity Ratio(JVR) as well as the intake geometry. The present study is conducted in a wind tunnel to provide accurate pressure destribution at the inlet wall and velocity field of the inlet and exit planes. Particle image velocimetry technique is used to obtain detail velocity fields. Pressure distributions and velocity field are discussed with accelerating and deaccelerating flow zones and the effect of JVR.

  7. Analyzing angular distributions for two-step dissociation mechanisms in velocity map imaging.

    Science.gov (United States)

    Straus, Daniel B; Butler, Lynne M; Alligood, Bridget W; Butler, Laurie J

    2013-08-15

    Increasingly, velocity map imaging is becoming the method of choice to study photoinduced molecular dissociation processes. This paper introduces an algorithm to analyze the measured net speed, P(vnet), and angular, β(vnet), distributions of the products from a two-step dissociation mechanism, where the first step but not the second is induced by absorption of linearly polarized laser light. Typically, this might be the photodissociation of a C-X bond (X = halogen or other atom) to produce an atom and a momentum-matched radical that has enough internal energy to subsequently dissociate (without the absorption of an additional photon). It is this second step, the dissociation of the unstable radicals, that one wishes to study, but the measured net velocity of the final products is the vector sum of the velocity imparted to the radical in the primary photodissociation (which is determined by taking data on the momentum-matched atomic cophotofragment) and the additional velocity vector imparted in the subsequent dissociation of the unstable radical. The algorithm allows one to determine, from the forward-convolution fitting of the net velocity distribution, the distribution of velocity vectors imparted in the second step of the mechanism. One can thus deduce the secondary velocity distribution, characterized by a speed distribution P(v1,2°) and an angular distribution I(θ2°), where θ2° is the angle between the dissociating radical's velocity vector and the additional velocity vector imparted to the product detected from the subsequent dissociation of the radical. PMID:23464815

  8. Breaking through: The effects of a velocity distribution on barriers to dust growth

    CERN Document Server

    Windmark, Fredrik; Ormel, Chris; Dullemond, Cornelis P

    2012-01-01

    It is unknown how far dust growth can proceed by coagulation. Obstacles to collisional growth are the fragmentation and bouncing barriers. However, in all previous simulations of the dust-size evolution in protoplanetary disks, only the mean collision velocity has been considered, neglecting that a small but possibly important fraction of the collisions will occur at both much lower and higher velocities. We study the effect of the probability distribution of impact velocities on the collisional dust growth barriers. Assuming a Maxwellian velocity distribution for colliding particles to determine the fraction of sticking, bouncing, and fragmentation, we implement this in a dust-size evolution code. We also calculate the probability of growing through the barriers and the growth timescale in these regimes. We find that the collisional growth barriers are not as sharp as previously thought. With the existence of low-velocity collisions, a small fraction of the particles manage to grow to masses orders of magnit...

  9. RNA polymerase motors: dwell time distribution, velocity and dynamical phases

    International Nuclear Information System (INIS)

    Polymerization of RNA from a template DNA is carried out by a molecular machine called RNA polymerase (RNAP). It also uses the template as a track on which it moves as a motor, utilizing chemical energy input. The time it spends at each successive monomer of DNA is random; we derive the exact distribution of these 'dwell times' in our model. The inverse of the mean dwell time satisfies a Michaelis–Menten-like equation and is also consistent with a general formula derived earlier by Fisher and Kolomeisky for molecular motors with unbranched mechano-chemical cycles. Often many RNAP motors move simultaneously on the same track. Incorporating the steric interactions among the RNAPs in our model, we also plot the three-dimensional phase diagram of our model for RNAP traffic using an extremum current hypothesis

  10. Comet Shoemaker-Levy 9 Dust Size and Velocity Distributions

    Science.gov (United States)

    Hahn, Joseph M.; Rettig, Terrence W.

    2000-01-01

    Pre-impact observations of Comet Shoemaker-Levy 9 (S-L9) obtained with the Hubble Space Telescope are examined, and a model of an active, dust-producing comet is fitted to images of fragments G, H, K, and L. The model assumes steady isotropic dust emission from each fragment's sunlit hemisphere. Best-fit results indicate that the dominant light-scatterers in these fragments' comae were relatively large dust grains of radii 10 micrometers < R < 3 mm. The fragments' dust size distributions were rather flat in comparison to other comets, dN(R) proportional to R(sup -2.3 +/- 0.1), and the dust ejection speeds were approximately 0.5-1.5 m/s. The S-L9 fragments themselves were not detected directly, and upper limits on their radii are 1.0-1.5 km assuming an albedo a = 0.04. However, these fragments' vigorous production of dust, which ranges from 6 to 22 kg/s, places a lower limit of approximately 100 m on their radii at the moment of tidal breakup. Any fragments smaller than this limit, yet experiencing similar mass loss rates, would have dissipated prior to impact. Such bodies would fail to leave an impact scar at Jupiter's atmosphere, as was realized by fragments F, J, P(sub 1), P(sub 2), T, and U.

  11. 16-Moment Approximation for Ion Velocity Distribution and its Application in Calculations of Incoherent Scatter Spectra

    Institute of Scientific and Technical Information of China (English)

    XUE Kun; GUO Lixin; WV Jian; XU Bin; FANG Chaofeng

    2009-01-01

    A sixteen moment approximation based on a bi-Maxwellian that contains the stress tensor and the heat flow vector is applied to describe the ion velocity distribution which influences the incoherent scatter spectra. A discussion is made about the effects on the incoherent scatter spectra caused by different values of the normalized perpendicular drift velocity D, aspect angle φ between the magnetic field and the line-of-sight direction, and the ratio α of the ion-neutral collision to ion cyclotron frequency. Numerical results show that the shifting and asymmetry of incoherent scatter spectra appear parallel to E × B and E as the normalized perpendicular drift velocity D increases due to the ion drift velocity, the stress tensor and the heat flow vector respectively. However, the spectrum is always typically double-humped Maxwellian parallel to B. The ion velocity distribution is more distorted from the Maxwellian as the aspect angle φ increases from 0° to 90°, and consequently the incoherent scatter spectra is no longer typically double-humped Maxwellian. As α increases, the ion velocity distribution becomes Maxwellian and the incoherent scatter spectra become typically double-humped Maxwellian even with a large value of the normalized perpendicular drift velocity D. It is reasonable to use the sixteen-moment approximation to describe the non-Maxwellian plasma characterized by the large temperature anisotropy.

  12. Impact of the dark matter velocity distribution on capture rates in the Sun

    International Nuclear Information System (INIS)

    Dark matter could be captured in the Sun and self-annihilate, giving rise to an observable neutrino flux. Indirect searches for dark matter looking for this signal with neutrino telescopes have resulted in tight constraints on the interaction cross-section of dark matter with ordinary matter. We investigate how robust limits are against astro-physical uncertainties. We study the effect of the velocity distribution of dark matter in our Galaxy on capture rates in the Sun. We investigate four sources of uncertainties: orbital speed of the Sun, escape velocity of dark matter from the halo, dark matter velocity distribution functions and existence of a dark disc. We find that even extreme cases currently discussed do not decrease the sensitivity of indirect detection significantly because the capture is achieved over a broad range of the velocity distribution by integration over the velocity distribution. The effect of the uncertainty in the high-velocity tail of dark matter halo is very marginal as the capture process is rather inefficient at this region. The difference in capture rate in the Sun for various scenarios is compared to the expected change in event rates for direct detection. The possibility of co-rotating structure with the Sun can largely boost the signal and hence makes the interpretation of indirect detection conservative compared to direct detection

  13. Role of electron-molecule angular scattering in shaping the electron-velocity distribution

    Energy Technology Data Exchange (ETDEWEB)

    Kunhardt, E.E.; Tzeng, Y.

    1986-09-01

    Five models has been studied to elucidate the role of electron-molecule angular scattering in shaping the velocity distribution for electrons in nitrogen at E/N values of 300 and 1500 Td. The angular dependence of the differential scattering cross sections for elastic and inelastic collisions has been observed to have significant effects on the shape of the velocity distribution, the rate coefficients, and the transport parameters. The velocity distribution is most sensitive to the angular dependence of elastic scattering. Moreover, for a given elastic differential scattering cross section, variations in the angular dependence of inelastic scattering cause significant changes in the distribution. The magnitude of these changes depends on the relative action of the inelastic collisions with respect to the elastic collisions for a given energy interval, i.e., whether the scattering by the inelastic collisions is isotropic, forward, or backward in a given energy interval.

  14. Non-local velocity distribution function and one-flight approximation

    Energy Technology Data Exchange (ETDEWEB)

    Bakunin, O.G. [FOM Instituut voor Plasmafysica ' Rijnhuizen' , Associate Euroatom-FOM, 3430 BE Nieuwegein (Netherlands) and Russian Research Center ' Kurchatov Institute' , Nuclear Fusion Institute, sq. Kurchatova 1, 123182 Moscow (Russian Federation)]. E-mail: oleg_bakunin@yahoo.com

    2004-09-13

    The functional equation describing the collisionless particle velocity distribution function f(V) is considered in the framework of probabilistic approach. The key element of the collisionless particles description is using the waiting time distribution {psi}(t). The solution of the considered functional is obtained for several model functions {psi}(t) and it leads to the power form tails of the velocity distribution f(V). It is possible to adopt considered functional to the Laplace transformation form that allows us to accord 'collision' and 'collisionless' description. This Laplace form of the functional yields the Levy-Smirnov velocity distribution function with the characteristic exponent aL=1/2.

  15. Cable energy function of cortical axons.

    Science.gov (United States)

    Ju, Huiwen; Hines, Michael L; Yu, Yuguo

    2016-01-01

    Accurate estimation of action potential (AP)-related metabolic cost is essential for understanding energetic constraints on brain connections and signaling processes. Most previous energy estimates of the AP were obtained using the Na(+)-counting method, which seriously limits accurate assessment of metabolic cost of ionic currents that underlie AP conduction along the axon. Here, we first derive a full cable energy function for cortical axons based on classic Hodgkin-Huxley (HH) neuronal equations and then apply the cable energy function to precisely estimate the energy consumption of AP conduction along axons with different geometric shapes. Our analytical approach predicts an inhomogeneous distribution of metabolic cost along an axon with either uniformly or nonuniformly distributed ion channels. The results show that the Na(+)-counting method severely underestimates energy cost in the cable model by 20-70%. AP propagation along axons that differ in length may require over 15% more energy per unit of axon area than that required by a point model. However, actual energy cost can vary greatly depending on axonal branching complexity, ion channel density distributions, and AP conduction states. We also infer that the metabolic rate (i.e. energy consumption rate) of cortical axonal branches as a function of spatial volume exhibits a 3/4 power law relationship. PMID:27439954

  16. Cable energy function of cortical axons

    Science.gov (United States)

    Ju, Huiwen; Hines, Michael L.; Yu, Yuguo

    2016-01-01

    Accurate estimation of action potential (AP)-related metabolic cost is essential for understanding energetic constraints on brain connections and signaling processes. Most previous energy estimates of the AP were obtained using the Na+-counting method, which seriously limits accurate assessment of metabolic cost of ionic currents that underlie AP conduction along the axon. Here, we first derive a full cable energy function for cortical axons based on classic Hodgkin-Huxley (HH) neuronal equations and then apply the cable energy function to precisely estimate the energy consumption of AP conduction along axons with different geometric shapes. Our analytical approach predicts an inhomogeneous distribution of metabolic cost along an axon with either uniformly or nonuniformly distributed ion channels. The results show that the Na+-counting method severely underestimates energy cost in the cable model by 20–70%. AP propagation along axons that differ in length may require over 15% more energy per unit of axon area than that required by a point model. However, actual energy cost can vary greatly depending on axonal branching complexity, ion channel density distributions, and AP conduction states. We also infer that the metabolic rate (i.e. energy consumption rate) of cortical axonal branches as a function of spatial volume exhibits a 3/4 power law relationship. PMID:27439954

  17. SPIDER IX - Classifying Galaxy Groups SPIDER IX - Classifying Galaxy Groups according to their Velocity Distribution

    CERN Document Server

    Ribeiro, A L B; de Carvalho, R R; La Barbera, F; Trevisan, M; Lopes, P A; Capelato, H V

    2013-01-01

    We introduce a new method to study the velocity distribution of galaxy systems, the Hellinger Distance (HD) - designed for detecting departures from a Gaussian velocity distribution. We define a relaxed galactic system as the one with unimodal velocity distribution and a normality deviation below a critical value (HD= 20) systems are significantly larger than in low multiplicity ones (N) and the gaussianity of the velocity distribution of the groups. Bright galaxies (M_r <=-20.7) residing in the inner and outer regions of groups, do not show significant differences in the listed quantities regardless if the group has a Gaussian (G) or a Non-Gaussian (NG) velocity distribution. However, the situation is significantly different when we examine the faint galaxies (-20.7

  18. TYPE Ia SUPERNOVA COLORS AND EJECTA VELOCITIES: HIERARCHICAL BAYESIAN REGRESSION WITH NON-GAUSSIAN DISTRIBUTIONS

    International Nuclear Information System (INIS)

    We investigate the statistical dependence of the peak intrinsic colors of Type Ia supernovae (SNe Ia) on their expansion velocities at maximum light, measured from the Si II λ6355 spectral feature. We construct a new hierarchical Bayesian regression model, accounting for the random effects of intrinsic scatter, measurement error, and reddening by host galaxy dust, and implement a Gibbs sampler and deviance information criteria to estimate the correlation. The method is applied to the apparent colors from BVRI light curves and Si II velocity data for 79 nearby SNe Ia. The apparent color distributions of high-velocity (HV) and normal velocity (NV) supernovae exhibit significant discrepancies for B – V and B – R, but not other colors. Hence, they are likely due to intrinsic color differences originating in the B band, rather than dust reddening. The mean intrinsic B – V and B – R color differences between HV and NV groups are 0.06 ± 0.02 and 0.09 ± 0.02 mag, respectively. A linear model finds significant slopes of –0.021 ± 0.006 and –0.030 ± 0.009 mag (103 km s–1)–1 for intrinsic B – V and B – R colors versus velocity, respectively. Because the ejecta velocity distribution is skewed toward high velocities, these effects imply non-Gaussian intrinsic color distributions with skewness up to +0.3. Accounting for the intrinsic-color-velocity correlation results in corrections to AV extinction estimates as large as –0.12 mag for HV SNe Ia and +0.06 mag for NV events. Velocity measurements from SN Ia spectra have the potential to diminish systematic errors from the confounding of intrinsic colors and dust reddening affecting supernova distances

  19. On the nature of bimodal initial velocity distribution of neutron stars

    OpenAIRE

    I. BombaciUniversità di Pisa, Dipartimento di Fisica;; Popov, S.B.

    2015-01-01

    We propose that the bimodal nature of the kick velocity distribution of radio pulsars is connected with the dichotomy between hadronic stars ({\\it i.e.} neutron stars with no quark matter content) and quark stars. Bimodality can appear due to different mechanisms of explosion which leads to the formation of two types of compact stars or due to two different sets of parameters mastering a particular kick mechanism. The low velocity maximum (at $\\sim 100$ km s$^{-1}$) is connected with hadronic...

  20. Power law in the angular velocity distribution of a granular needle

    OpenAIRE

    Piasecki, J.; Viot, P.

    2005-01-01

    We show how inelastic collisions induce a power law with exponent -3 in the decay of the angular velocity distribution of anisotropic particles with sufficiently small moment of inertia. We investigate this question within the Boltzmann kinetic theory for an elongated granular particle immersed in a bath. The power law persists so long as the collisions are inelastic for a large range of angular velocities provided the mass ratio of the anisotropic particle and the bath particles remains smal...

  1. Galactic Subsystems on the Basis of Cumulative Distribution of Space Velocities

    Directory of Open Access Journals (Sweden)

    Vidojević, S.

    2008-12-01

    Full Text Available A sample containing $4,614$ stars with available space velocities and high-quality kinematical data from the Arihip Catalogue is formed. For the purpose of distinguishing galactic subsystems the cumulative distribution of space velocities is studied. The fractions of the three subsystems are found to be: thin disc 92\\%, thick disc 6\\% and halo 2\\%. These results are verified by analysing the elements of velocity ellipsoids and the shape and size of the galactocentric orbits of the sample stars, i.e. the planar and vertical eccentricities of the orbits.

  2. Precision measurement of transverse velocity distribution of a Strontium atomic beam

    CERN Document Server

    Gao, F; Xu, P; Tian, X; Wang, Y; Ren, J; Wu, Haibin; Chang, Hong

    2013-01-01

    We measure precisely the transverse velocity distribution in a thermal Sr atomic beam with a velocity selective saturated fluorescence spectroscopy. By using the ultrastable laser system and narrow intercombination transition line of Sr atoms, the resolution of the velocity measured can be reached 0.13m/s, corresponding to 90$\\mu K$ in energy unit. The experimental results are agreement very well with a theoretical calculation. With the spectroscopic techniques, the absolute frequency of the intercombination transition of $^{88}$Sr is measured by an optical-frequency comb generator referenced to the SI second through an H maser, which is given by 434 829 121 318(10)kHz.

  3. The ESO nearby Abell cluster survey; 2, the distribution of velocity dispersions of rich galaxy clusters

    CERN Document Server

    Mazure, A

    1995-01-01

    Summary - By combining the 5634 redshifts from the ESO Nearby Abell Cluster Survey (the ENACS) with another 1000 redshifts from the literature we are able to study the distribution of velocity dispersions for a volume-limited sample of 128 R_{\\rm ACO} \\geq 1 clusters, out to a redshift z=0.1, in a solid angle of 2.55 sr centered on the South Galactic Pole. In deriving velocity dispersions we apply a new, physically motivated method for removing fore- and background galaxies. We discuss in detail the completeness of the cluster sample for which we derive the distribution of cluster velocity dispersions. The large apparent spread between velocity dispersion and richness must be largely intrinsic. A consequence of the very broad relation between richness and velocity dispersion is that all cluster samples complete in richness are biased against low dispersions. For the richness limit of our sample this bias operates below about 800 km/sec. Above 800 km/s, our distribution of global velocity dispersions is free f...

  4. Computing along the axon

    Institute of Scientific and Technical Information of China (English)

    Chen Haiming; Tseren-Onolt Ishdorj; Gheorghe Pǎun

    2007-01-01

    A special form of spiking neural P systems, called axon P systems, corresponding to the activity of Ranvier nodes of neuron axon, is considered and a class of SN-like P systems where the computation is done along the axon is introduced and their language generative power is investigated.

  5. Application of electromagnetic velocity meter for measuring liquid velocity distribution in air-water two-phase flow along a large vertical pipe

    International Nuclear Information System (INIS)

    An electromagnetic velocity meter has been applied to measure the liquid velocity distribution along a large vertical pipe (Inner diameter: 0.48 m, Length of flow path: 2 m) under air-water two-phase flow. This measurement is performed to examine the flow structure along the large vertical pipe where the flow structure has not been fully understood yet. The experiment was performed under atmospheric pressure and superficial air and water velocities in the test section were 0.02--0.87 m/s and 0.01--0.2 m/s, respectively. The accuracy of the electromagnetic velocity meter was firstly checked and was confirmed to be within the error of ±10% for the local liquid velocity up to about 2 m/s under bubbly two-phase flow. The velocity meter was used to measure the radial distribution of local liquid velocity including flow direction in the large vertical pipe. With increasing air flow rate, the axial liquid velocity at the center of the pipe becomes higher, the direction of axial liquid flow near the wall becomes downward and the degree of anisotropy of liquid velocity fluctuation becomes larger. A developing region exists below about 1 m from the bottom of the test section and the flow structure above the elevation is considered to be almost developed based on the measurement of the radial distribution of axial liquid velocity

  6. Velocity fluctuations and population distribution in clusters of settling particles at low Reynolds number

    CERN Document Server

    Boschan, A; Annichini, M; Gauthier, G

    2016-01-01

    A study on the spatial organization and velocity fluctuations of non Brownian spherical particles settling at low Reynolds number in a vertical Hele-Shaw cell is reported. The particle volume fraction ranged from 0.005 to 0.05, while the distance between cell plates ranged from 5 to 15 times the particle radius. Particle tracking revealed that particles were not uniformly distributed in space but assembled in transient settling clusters. The population distribution of these clusters followed an exponential law. The measured velocity fluctuations are in agreement with that predicted theoretically for spherical clusters, from the balance between the apparent weight and the drag force. This result suggests that particle clustering, more than a spatial distribution of particles derived from random and independent events, is at the origin of the velocity fluctuations.

  7. Velocity fluctuations and population distribution in clusters of settling particles at low Reynolds number

    Science.gov (United States)

    Boschan, A.; Ocampo, B. L.; Annichini, M.; Gauthier, G.

    2016-06-01

    A study on the spatial organization and velocity fluctuations of non-Brownian spherical particles settling at low Reynolds number in a vertical Hele-Shaw cell is reported. The particle volume fraction ranged from 0.005 to 0.05, while the distance between cell plates ranged from 5 to 15 times the particle radius. Particle tracking revealed that particles were not uniformly distributed in space but assembled in transient settling clusters. The population distribution of these clusters followed an exponential law. The measured velocity fluctuations are in agreement with that predicted theoretically for spherical clusters, from the balance between the apparent weight and the drag force. This result suggests that particle clustering, more than a spatial distribution of particles derived from random and independent events, is at the origin of the velocity fluctuations.

  8. Photoelectric dust levitation around airless bodies revised using realistic photoelectron velocity distributions

    Science.gov (United States)

    Senshu, H.; Kimura, H.; Yamamoto, T.; Wada, K.; Kobayashi, M.; Namiki, N.; Matsui, T.

    2015-10-01

    The velocity distribution function of photoelectrons from a surface exposed to solar UV radiation is fundamental to the electrostatic status of the surface. There is one and only one laboratory measurement of photoelectron emission from astronomically relevant material, but the energy distribution function was measured only in the emission angle from the normal to the surface of 0 to about π / 4. Therefore, the measured distribution is not directly usable to estimate the vertical structure of a photoelectric sheath above the surface. In this study, we develop a new analytical method to calculate an angle-resolved velocity distribution function of photoelectrons from the laboratory measurement data. We find that the photoelectric current and yield for lunar surface fines measured in a laboratory have been underestimated by a factor of two. We apply our new energy distribution function of photoelectrons to model the formation of photoelectric sheath above the surface of asteroid 433 Eros. Our model shows that a 0.1 μm-radius dust grain can librate above the surface of asteroid 433 Eros regardless of its launching velocity. In addition, a 0.5 μm grain can hover over the surface if the grain was launched at a velocity slower than 0.4 m/s, which is a more stringent condition for levitation than previous studies. However, a lack of high-energy data on the photoelectron energy distribution above 6 eV prevents us from firmly placing a constraint on the levitation condition.

  9. Search for a Lorentz invariant velocity distribution of a relativistic gas

    Science.gov (United States)

    Curado, Evaldo M. F.; Germani, Felipe T. L.; Soares, Ivano Damião

    2016-02-01

    We examine the problem of the relativistic velocity distribution in a 1-dim relativistic gas in thermal equilibrium. We use numerical simulations of the relativistic molecular dynamics for a gas with two components, light and heavy particles. However in order to obtain the numerical data our treatment distinguishes two approaches in the construction of the histograms for the same relativistic molecular dynamic simulations. The first, largely considered in the literature, consists in constructing histograms with constant bins in the velocity variable and the second consists in constructing histograms with constant bins in the rapidity variable which yields Lorentz invariant histograms, contrary to the first approach. For histograms with constant bins in the velocity variable the numerical data are fitted accurately by the Jüttner distribution which is also not Lorentz invariant. On the other hand, the numerical data obtained from histograms constructed with constant bins in the rapidity variable, which are Lorentz invariant, are accurately fitted by a Lorentz invariant distribution whose derivation is discussed in this paper. The histograms thus constructed are not fitted by the Jütter distribution (as they should not). Our derivation is based on the special theory of relativity, the central limit theorem and the Lobachevsky structure of the velocity space of the theory, where the rapidity variable plays a crucial role. For v2 /c2 ≪ 1 and 1 / β ≡kB T /m0c2 ≪ 1 the distribution tends to the Maxwell-Boltzmann distribution.

  10. Measurements of neutral and ion velocity distribution functions in a Hall thruster

    Science.gov (United States)

    Svarnas, Panagiotis; Romadanov, Iavn; Diallo, Ahmed; Raitses, Yevgeny

    2015-11-01

    Hall thruster is a plasma device for space propulsion. It utilizes a cross-field discharge to generate a partially ionized weakly collisional plasma with magnetized electrons and non-magnetized ions. The ions are accelerated by the electric field to produce the thrust. There is a relatively large number of studies devoted to characterization of accelerated ions, including measurements of ion velocity distribution function using laser-induced fluorescence diagnostic. Interactions of these accelerated ions with neutral atoms in the thruster and the thruster plume is a subject of on-going studies, which require combined monitoring of ion and neutral velocity distributions. Herein, laser-induced fluorescence technique has been employed to study neutral and single-charged ion velocity distribution functions in a 200 W cylindrical Hall thruster operating with xenon propellant. An optical system is installed in the vacuum chamber enabling spatially resolved axial velocity measurements. The fluorescence signals are well separated from the plasma background emission by modulating the laser beam and using lock-in detectors. Measured velocity distribution functions of neutral atoms and ions at different operating parameters of the thruster are reported and analyzed. This work was supported by DOE contract DE-AC02-09CH11466.

  11. Angular and velocity distributions of NO scattered from the Pt(111) crystal surface

    Energy Technology Data Exchange (ETDEWEB)

    Guthrie, W.L.; Lin, T.; Ceyer, S.T.; Somorjai, G.A.

    1982-06-15

    The angular and velocity distributions of NO scattered from the Pt(111) surface have been measured for a crystal temperature range of 475--1200 K and for an incident beam energy range of 265--1390 K. Both angular and velocity distributions confirm the coexistence of inelastic and trapping-desorption scattering processes. For beams with a kinetic energy of /2k equal to 265 and 615 K, the molecules scattered into angles near the surface normal were found to be equilibrated with the surface for T/sub s/ between 475 and 900 K.

  12. Simulation of quiet start magnetized plasmas, including Maxwellian and velocity-space ring distributions

    International Nuclear Information System (INIS)

    Longitudinal electrostatic waves are simulated in a magnetized plasma, propagating perpendicular to B0. Groups of particles are arranged in one or more rings and spokes in velocity space. Using various loading schemes to represent different particle velocity-space distributions in the simulations, f(upsilon/sub perpendicular/), these particles are then distributed uniformly in position space along the length of the system. In particular, the evolution of magnetized cold and warm rings is followed (physically unstable), and of a magnetized Maxwellian (unstable due to the particle loading) through to saturation. Rules are deduced for useful loading methods

  13. VELOCITY DISTRIBUTION IN TRAPEZOID-SECTION OPEN CHANNEL FLOW WITH A NEW REYNOLDS-STRESS EXPRESSION

    Institute of Scientific and Technical Information of China (English)

    Ma Zheng

    2003-01-01

    By considering that the coherent structure is the main cause of the Reynolds stress, a new Reynolds stress expression was given. On this basis the velocity distribution in the trapezoid-section open channel flow was worked out with the pseudo-spectral method. The results were compared with experimental data and the influence of the ratio of length to width of the cross-section and the lateral inclination on the velocity distribution was analyzed. This model can be used the large flux in rivers and open channes.

  14. Velocity distribution of fusion-like products for medium mass heavy-ion systems

    International Nuclear Information System (INIS)

    Reactions between 14N, 16O, 19F, 20Ne, 22Ne, 24Mg projectiles and 24Mg, 26Mg, 27Al, 28Si, 40Ca, 58Ni, 60Ni targets have been studied at 7-20 MeV/nucleon. The velocity distribution of nuclear fragments was measured in order to infer the velocity of the compound nucleus prior to decay. The dependences of the distribution on projectile energy and projectile type were obtained. Obtaining cross sections for reaction processes from the data is discussed

  15. Influence of anisotropy on velocity and age distribution at Scharffenbergbotnen blue ice area

    Directory of Open Access Journals (Sweden)

    T. Zwinger

    2013-06-01

    Full Text Available We use a full-Stokes thermo-mechanically coupled ice-flow model to study the dynamics of the glacier inside Scharffenbergbotnen valley, Dronning Maud Land, Antarctica. The domain encompasses a high accumulation rate region and, downstream a sublimation-dominated bare ice ablation area. The ablation ice area is notable for having old ice at its surface since the vertical velocity is upwards, and horizontal velocities are almost stagnant there. We compare the model simulation with field observations of velocities and the age distribution of the surface ice. A satisfactory match with simulations using an isotropic flow law was not found because of too high horizontal velocities and too slow vertical ones. However, the existence of a pronounced ice fabric may explain the present day surface velocity distribution in the inner Scharffenbergbotnen blue ice area. Near absence of data on the temporal evolution of Scharffenbergbotnen since the Late Glacial Maximum necessitates exploration of the impact of anisotropy using prescribed ice fabrics: isotropic, single maximum, and linear variation with depth, in both two-dimensional and three dimensional flow models. The realistic velocity field simulated with a non-collinear orthotropic flow law, however produced surface ages in significant disagreement with the few reliable age measurements and suggests that the age field is not in a steady state and that the present distribution is a result of a flow reorganization at about 15 000 yr BP. In order to fully understand the surface age distribution a transient simulation starting from the Late Glacial Maximum including the correct initial conditions for geometry, age, fabric and temperature distribution would be needed. It is the first time that the importance of anisotropy has been demonstrated in the ice dynamics of a blue ice area. This is useful to understand ice flow in order to better interpret archives of ancient ice for paleoclimate research.

  16. Lateral distributions of streamwise velocity in compound channels with partially vegetated floodplains

    Institute of Scientific and Technical Information of China (English)

    KNIGHT; Donald; W

    2009-01-01

    Natural rivers are commonly characterized by a main channel for primary flow conveyance and a floodplain, often partially covered with vegetation such as shrubs or trees, to carry extra flow during floods. The hydraulic resistance due to vegetation on the floodplain typically causes a further reduction of flow velocity and increases the velocity difference between the main channel and the floodplain. As a consequence a strong lateral shear layer leads to the exchange of mass and momentum between the main channel and floodplain, which in turn affects the overall channel conveyance and certain fluvial processes. The prediction of the lateral velocity distribution is important for many flood alleviation schemes, as well as for studies on sediment transport and dispersion in such channels. The present paper proposes a method for predicting the depth-averaged velocity in compound channels with partially vegetated floodplains, based on an analytical solution to the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term included to account for the effects of vegetation. The vegetation is modelled via an additional term in the momentum equation to account for the additional drag force. The method includes the effects of bed friction, drag force, lateral turbulence and secondary flows, via four coefficients f, CD, λ & Γ respectively. The predicted lateral distributions of depth-averaged velocity agree well with the experimental data. The analytical solutions can also be used to predict the distribution of boundary shear stresses, which adds additional weight to the method proposed.

  17. Velocity-space structures of distribution function in toroidal ion temperature gradient turbulence

    International Nuclear Information System (INIS)

    Velocity-space structures of ion distribution function associated with the ion temperature gradient (ITG) turbulence and the collisionless damping of the zonal flow are investigated by means of a newly developed toroidal gyrokinetic-Vlasov simulation code with high velocity-space resolution. The present simulation on the zonal flow and the geodesic acoustic mode (GAM) successfully reproduces the neoclassical polarization of trapped ions as well as the parallel phase mixing due to passing particles. During the collisionless damping of GAM, finer-scale structures of the ion distribution function in the velocity space continue to develop due to the phase mixing while preserving an invariant defined by a sum of an entropy variable and the potential energy. Simulation results of the the toroidal ITG turbulent transport clearly show generation of the fine velocity-space structures of the distribution function and their collisional dissipation. Detailed calculation of the entropy balance confirms the statistically steady state of turbulence, where the anomalous transport balances with the dissipation given by the weak collisionality. The above results obtained by simulations with high velocity-space resolution are understood in terms of generation, transfer, and dissipation processes of the entropy variable in the phase space. (author)

  18. Velocity-space structures of distribution function in toroidal ion temperature gradient turbulence

    International Nuclear Information System (INIS)

    Velocity-space structures of ion distribution function associated with the ion temperature gradient (ITG) turbulence and the collisionless damping of the zonal flow are investigated by means of a newly developed toroidal gyrokinetic-Vlasov simulation code with high velocity-space resolution. The present simulation on the zonal flow and the geodesic acoustic mode (GAM) successfully reproduces the neoclassical polarization of trapped ions as well as the parallel phase mixing due to passing particles. During the collisionless damping of GAM, finer-scale structures of the ion distribution function in the velocity space continue to develop due to the phase mixing while preserving an invariant defined by a sum of an entropy variable and the potential energy. Simulation results of the toroidal ITG turbulent transport clearly show generation of the fine velocity-space structures of the distribution function and their collisional dissipation. Detailed calculation of the entropy balance confirms the statistically steady state of turbulence, where the anomalous transport balances with the dissipation given by the weak collisionality. The above results obtained by simulations with high velocity-space resolution are also understood in terms of generation, transfer, and dissipation processes of the entropy variable in the phase space. (author)

  19. Dynamics of mitochondrial transport in axons

    Directory of Open Access Journals (Sweden)

    Robert Francis Niescier

    2016-05-01

    Full Text Available The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons.

  20. Dynamics of Mitochondrial Transport in Axons.

    Science.gov (United States)

    Niescier, Robert F; Kwak, Sang Kyu; Joo, Se Hun; Chang, Karen T; Min, Kyung-Tai

    2016-01-01

    The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons. PMID:27242435

  1. Velocity and electronic state distributions of sputtered Fe atoms by laser-induced fluorescence spectroscopy

    International Nuclear Information System (INIS)

    Velocity distributions and relative populations in the fine-structure levels of the a5D/sub J/ ground state of Fe atoms, produced by sputtering with 3 keV argon ions, have been investigated by Doppler shifted laser induced fluorescence. The laser system employs a single-mode, scanning ring dye laser, amplified by a sequence of three excimer-pumped flowing-dye cells. Frequency doubling in a KD*P crystal was used to produce high energy (> .5 mJ) pulses of narrowband tunable UV output near 300 nm. Laser power influence on effective velocity bandwidth was investigated. Favorable light-collection geometry minimized distortion of the velocity spectra from apparatus-averaging effects. In impurity flux diagnostic applications in fusion devices, substantial spatial averaging may occur. In the latter case, the narrow velocity bandwidth (70 m/s, transform limit) of the present laser system is particularly useful

  2. A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

    Science.gov (United States)

    Micheva, Kristina D; Wolman, Dylan; Mensh, Brett D; Pax, Elizabeth; Buchanan, JoAnn; Smith, Stephen J; Bock, Davi D

    2016-01-01

    Myelin is best known for its role in increasing the conduction velocity and metabolic efficiency of long-range excitatory axons. Accordingly, the myelin observed in neocortical gray matter is thought to mostly ensheath excitatory axons connecting to subcortical regions and distant cortical areas. Using independent analyses of light and electron microscopy data from mouse neocortex, we show that a surprisingly large fraction of cortical myelin (half the myelin in layer 2/3 and a quarter in layer 4) ensheathes axons of inhibitory neurons, specifically of parvalbumin-positive basket cells. This myelin differs significantly from that of excitatory axons in distribution and protein composition. Myelin on inhibitory axons is unlikely to meaningfully hasten the arrival of spikes at their pre-synaptic terminals, due to the patchy distribution and short path-lengths observed. Our results thus highlight the need for exploring alternative roles for myelin in neocortical circuits. DOI: http://dx.doi.org/10.7554/eLife.15784.001 PMID:27383052

  3. Distributed tracking for networked Euler-Lagrange systems without velocity measurements

    Institute of Scientific and Technical Information of China (English)

    Qingkai Yang; Hao Fang; Yutian Mao; Jie Huang

    2014-01-01

    The problem of distributed coordinated tracking control for networked Euler-Lagrange systems without velocity measure-ments is investigated. Under the condition that only a portion of the fol owers have access to the leader, sliding mode estimators are developed to estimate the states of the dynamic leader in fi-nite time. To cope with the absence of velocity measurements, the distributed observers which only use position information are designed. Based on the outputs of the estimators and observers, distributed tracking control laws are proposed such that al the fol-lowers with parameter uncertainties can track the dynamic leader under a directed graph containing a spanning tree. It is shown that the distributed observer-control er guarantees asymptotical stabil-ity of the closed-loop system. Numerical simulations are worked out to il ustrate the effectiveness of the control laws.

  4. Electron velocity distribution instability in magnetized plasma wakes and artificial electron mass

    CERN Document Server

    Hutchinson, I H

    2011-01-01

    The wake behind a large object (such as the moon) moving rapidly through a plasma (such as the solar wind) contains a region of depleted density, into which the plasma expands along the magnetic field, transverse to the flow. It is shown here that (in addition to any ion instability) a bump-on-tail which is unstable appears on the electrons' parallel velocity distribution function because of the convective non-conservation of parallel energy. It arises regardless of any non-thermal features on the external electron velocity distribution. The detailed electron distribution function throughout the wake is calculated by integration along orbits; and the substantial energy level of resulting electron plasma (Langmuir) turbulence is evaluated quasilinearly. It peaks near the wake axis. If the mass of the electrons is artificially enhanced, for example in order to make numerical simulation feasible, then much more unstable electron distributions arise; but these are caused by the unphysical mass ratio.

  5. Experimental Study on the Distribution of Velocity and Pressure near a Submarine Pipeline

    Institute of Scientific and Technical Information of China (English)

    HAN Yan; SHI Bing; REN Xingyue; JING Xiaodong

    2009-01-01

    As a transport means of oil and gas the submarine pipeline has many merits, such as continuous delivery, large conveying capacity, convenient management, etc. A tube was chosen in our study to simulate the submarine pipeline in the experiments. A high accuracy instrument ADV and high precision point-type pressure sensors were used to measure the parameters of the flow field, including the pressure distribution, velocities at seven cross sections near the submarine pipeline with five different clearance ratios, and twelve dynamic pressure values around the pipeline. The pressure distributions and velocity changes around the pipe under different flow velocities and clearance ratios were analyzed. These results might be useful for further study of submarine pipeline erosion and protection.

  6. Velocity Distribution in the Flow from a Wall-Mounted Diffuser in Rooms with Displacement Ventilation

    DEFF Research Database (Denmark)

    Nielsen, Peter V.

    The paper describes experiments with wall-mounted air terminal devices. The airflow from an air terminal device will influence the thermal comfort of the occupants and it is therefore important to develop an expression for this flow. The velocity at the floor is influenced by the flow rate to the...... room, by the temperature difference and the type of diffuser. The flow is stratified at large temperature differences. The paper shows the development of an expression for the velocity distribution in the vicinity of the floor. It is shown that openings between obstacles placed directly on the floor...... will generate a flow similar to the air movement in front of a diffuser. An expression for the velocity distribution is given in the paper....

  7. State-selective velocity and angular distributions of NO molecules scattered from a graphite surface

    Energy Technology Data Exchange (ETDEWEB)

    Hager, J.; Shen, Y.R.; Walther, H.

    1985-03-01

    Laser ionization was used to measure the state-selective angular and velocity distributions of NO molecules scattered from a graphite surface. The data showed that at sufficiently low surface temperatures, the scattered molecules were generally composed of quasispecular reflected part and a diffusive scattered part with different translational and rotational behavior.

  8. Tomography of fast-ion velocity-space distributions from synthetic CTS and FIDA measurements

    DEFF Research Database (Denmark)

    Salewski, Mirko; Geiger, B.; Nielsen, Stefan Kragh;

    2012-01-01

    We compute tomographies of 2D fast-ion velocity distribution functions from synthetic collective Thomson scattering (CTS) and fast-ion D (FIDA) 1D measurements using a new reconstruction prescription. Contradicting conventional wisdom we demonstrate that one single 1D CTS or FIDA view suffices to...

  9. Velocity-space tomography of the fast-ion distribution function

    DEFF Research Database (Denmark)

    Jacobsen, Asger Schou; Salewski, Mirko; Geiger, Benedikt;

    2013-01-01

    Fast ions play an important role in heating the plasma in a magnetic confinement fusion device. Fast-ion Dα(FIDA) spectroscopy diagnoses fast ions in small measurement volumes. Spectra measured by a FIDA diagnostic can be related to the 2D fast-ion velocity distribution function. A single FIDA vi...

  10. The spatial distributions of the sources of UV solar Explosive Events at different velocities

    Science.gov (United States)

    Mendoza-Torres, J. E.

    2013-01-01

    We analyze five solar Explosive Events observed in the Si IV emission line at 139.37 nm during SUMER/SoHO raster scans near disk center. The Doppler velocities from -45 km s-1 to +45 km s-1 were sorted into eleven symmetrically organized velocity bins, five equally-sized bins on each side and one bin for the line at rest. The radiance values along the NS oriented slit around the maximum of each EE are used to build one-dimensional distributions. We study these distributions and their development in space and time for different velocity bins to unveil the 3D-structure and evolution of Explosive Events. The spatial radiance distributions for the EE maximum and around it were made. For some Explosive Events the dispersion direction is not oriented orthogonally to the slit direction; consequently, the blueshifted emission is in a linear way offset from the redshifted emission by several pixels. The largest offset (˜5″) is observed between distributions whose velocities differ by ˜36 km s-1. The linear relation agrees with an scenario of flows inside magnetic arcs.

  11. Relaxation Time of the Particle Beam with an Anisotropic Velocity Distribution

    Directory of Open Access Journals (Sweden)

    V.P. Vechirka

    2012-11-01

    Full Text Available The computer experiment for study of the relaxation time of the beam particles with an anisotropic velocity distribution is performed by the molecular dynamics. Obtained results agree with the characteristic times of thermal relaxation in plasma for the electronic coolers in modern storage rings.

  12. Sodium Atoms in the Lunar Exotail: Observed Velocity and Spatial Distributions

    Science.gov (United States)

    Line, Michael R.; Mierkiewicz, E. J.; Oliversen, R. J.; Wilson, J. K.; Haffner, L. M.; Roesler, F. L.

    2011-01-01

    The lunar sodium tail extends long distances due to radiation pressure on sodium atoms in the lunar exosphere. Our earlier observations determined the average radial velocity of sodium atoms moving down the lunar tail beyond Earth along the Sun-Moon-Earth line (i.e., the anti-lunar point) to be 12.4 km/s. Here we use the Wisconsin H-alpha Mapper to obtain the first kinematically resolved maps of the intensity and velocity distribution of this emission over a 15 x times 15 deg region on the sky near the anti-lunar point. We present both spatially and spectrally resolved observations obtained over four nights around new moon in October 2007. The spatial distribution of the sodium atoms is elongated along the ecliptic with the location of the peak intensity drifting 3 degrees east along the ecliptic per night. Preliminary modeling results suggest that the spatial and velocity distributions in the sodium exotail are sensitive to the near surface lunar sodium velocity distribution and that observations of this sort along with detailed modeling offer new opportunities to describe the time history of lunar surface sputtering over several days.

  13. Velocity Distribution in a Room Ventilated by Displacement Ventilation and Wall-Mounted Air Terminal Devices

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm

    2000-01-01

    flow rate to the room, the temperature difference and the type of diffuser. The flow is stratified at Archimedes numbers larger than four. The article gives expressions for the velocity distribution close to the floor. It is shown that openings between obstacles placed directly on the floor generate a...

  14. Measurement of water distribution by using neutron radiography and network analysis of gas-velocity distributions in a PEFC

    International Nuclear Information System (INIS)

    Fuel gas (hydrogen gas) and oxidant gas (air) are supplied to a Polymer Electrolyte Fuel Cell (PEFC). Condensation may occur in the cathode side, since air is super-saturated by the fuel cell reactions. If condensed water exists in a gas diffusion layer (GDL) or the gas channels, it may affect the fuel cell performances because of blocking the oxygen from reaching the cathode reaction site. In order to clarify water effects on performances of a PEFC, visualization and quantitative measurements of water distributions in a PEFC were carried out by means of neutron radiography. A network analysis of gas-velocity distribution was applied for the experimental results. It analyzes the gas-velocity distribution depending on the flow resistance which is the pressure drop. Applying the measured data of water thickness, pressure drop in the gas channel and the GDL can be obtained. (author)

  15. Electron Velocity Distribution Function in Magnetic Clouds in the Solar Wind

    Science.gov (United States)

    Nieves-Chinchil, Teresa; Vinas, Adolfo F.; Bale, Stuart D.

    2006-01-01

    We present a study of the kinetic properties of the electron velocity distribution functions within magnetic clouds, since they are the dominant thermal component. The study is based on high time resolution data from the GSFC WIND/SWE electron spectrometer and the Berkeley 3DP electron plasma instruments. Recent studies on magnetic clouds have shown observational evidence of anti-correlation between the total electron density and electron temperature, which suggest a polytrope law P(sub e) = alpha(Nu(sub e) (sup gamma)) for electrons with the constant gamma approximates 0.5 electron distributions (i.e. non-thermal) within magnetic clouds. These works suggested that the non-thermal electrons can contribute as much as 50% of the total electron pressure within magnetic clouds. We have revisited some of the magnetic cloud events previously studied and attempted to quantify the nature of the non-thermal electrons by modeling the electron velocity distribution function using a kappa distribution function to characterize the kinetic non-thermal effects. If non-thermal tail effects are the source for the anti-correlation between the moment electron temperature and density and if the kappa distribution is a reasonable representative model of non-thermal effects, then the electron velocity distribution within magnetic clouds should show indication for small K-values when gamma < 1.

  16. Using diffusion anisotropy to characterize neuronal morphology in gray matter: the orientation distribution of axons and dendrites in the NeuroMorpho.org database

    Directory of Open Access Journals (Sweden)

    Mikkel B Hansen

    2013-05-01

    Full Text Available Accurate mathematical modeling is integral to the ability to interpret diffusion magneticresonance (MR imaging data in terms of cellular structure in brain gray matter (GM. Inprevious work, we derived expressions to facilitate the determination of the orientationdistribution of axonal and dendritic processes from diffusion MR data. Here we utilize neuronreconstructions available in the NeuroMorpho database (www.neuromorpho.org to assess thevalidity of the model we proposed by comparing morphological properties of the neurons topredictions based on diffusion MR simulations using the reconstructed neuron models. Initially,the method for directly determining neurite orientation distributions is shown to not depend onthe line length used to quantify cylindrical elements. Further variability in neuron morphology ischaracterized relative to neuron type, species, and laboratory of origin. Subsequently, diffusionMR signals are simulated based on human neocortical neuron reconstructions. This reveals a biasin which diffusion MR data predict neuron orientation distributions to have artificially lowanisotropy. This bias is shown to arise from shortcomings (already at relatively low diffusionweighting in the Gaussian approximation of diffusion, in the presence of restrictive barriers, anddata analysis methods involving higher moments of the cumulant expansion are shown to becapable of reducing the magnitude of the observed bias.

  17. A laboratory study of the dependence of elastic wave velocities on pore scale fluid distribution

    Energy Technology Data Exchange (ETDEWEB)

    Knight, R. (Univ. of British Columbia, Vancouver (Canada)); Nolen-Hoeksema, R. (Stanford Univ., CA (USA))

    1990-09-01

    Laboratory data have been collected during a continuous imbibition/drainage experiment that show a clear dependence of elastic wave velocities on the details of the pore scale distribution of water and air in a sandstone. Compressional wave velocity (Vp) was measured at a frequency of 1 MHz; shear wave velocity (Vs) was measured at a frequency of 600 kHz. During the experiment, Vp showed little variation with the level of water saturation (Sw) during increasing Sw through imbibition until Sw = 0.80, at which point Vp increased dramatically. When Sw was decreased, pronounced saturation-induced hysteresis was observed in the region 0.3 < Sw < 0.9, with Vp measured during drainage greater than Vp measured during imbibition. Similar results were obtained for Vs versus Sw, with Vs during drainage greater that Vs during imbibition in the saturation range Sw > 0.4. As a simple model, the authors consider the imbibition process as producing a partially saturated state in all pores; i.e. all pores contain both air and water. The drainage process, in contrast, favors the existence of either air-filled or water-filled pores. As elastic wave velocities are very sensitive to the saturation state in the smaller, crack-like pores, these variations in fluid distribution cause related variations in velocities.

  18. Study of the Spatial Distribution of Burning Particles in a Pyrotechnic Flame Based on Particle Velocity

    Science.gov (United States)

    Zhu, Chen-Guang; Xu, Chungen; Xue, Rui

    2014-10-01

    The burning particles in the pyrotechnic flame play an important role in the ignition and spectral radiance of the pyrotechnic. We used particle image velocimetry (PIV) and high-speed camera (HSC) photography to investigate the 3D spatial pattern and velocity of the burning particles in the flame of pyrotechnics. The original images captured by the HSC were preprocessed through threshold selection, image bivalency, edge detection, and contour extraction and segmentation to obtain the particle coordinates and velocity. Consequently, the particle tracking model was established and the velocity and spatial distribution of the burning particles were obtained. A comparison of the flame flow field with particle image velocimetry demonstrated the typical characteristics of the two-phase flow of the pyrotechnic flame between burning particles and gas. Compared with the convergent gas flow field, the higher velocity burning particles had a discrete distribution in the "comet tail" shape region and showed the same direction of motion as the flame flow field, whereas the lower velocity burning particles had larger outlying regions and showed inconsistent directions of motion. The flow field of the burning particles was more chaotic than the flame flow field of the burning pyrotechnics.

  19. Planar Velocity Distribution of Viscous Debris Flow at Jiangjia Ravine, Yunnan, China: A Field Measurement Using Two Radar Velocimeters

    Institute of Scientific and Technical Information of China (English)

    FU Xudong; WANG Guangqian; KANG Zhicheng; FEI Xiangjun

    2007-01-01

    Characteristics of planar velocity distribution of viscous debris flow were analyzed using the measured data at Jiangjia Ravine, Yunnan, China. The velocity data were measured through using two radar velocimeters. The cross-sectional mean velocities were calculated and used to examine Kang et al's (2004) relationship, which was established for converting the flow velocity at river centerline measured by a radar velocimeter into the mean velocity based on the stop-watch method. The velocity coefficient, K, defined by the ratio of the mean velocity to the maximum velocity, ranges from 0.2 to 0.6. Kang et al's (2004) relationship was found being inapplicable to flows with K smaller than 0.43. This paper contributes to show the complexity of the planar velocity distribution of viscous debris flows and the applicability of Kang et al's relationship.

  20. Mixture parameters of a trivariate normal superposition from sample cumulants: application to the local stellar velocity distribution

    OpenAIRE

    Cubarsí Morera, Rafael; Alcobé López, Santiago

    2000-01-01

    The velocity distribution of nearby stars can be studied as a mixture of two main population components. In order to determine the mixing proportions and the population parameters a combined geometric-statistical method has been developed. The overall distribution is approximated from a superposition of two trivariate normal velocity density functions. The peculiar velocity is projected on a plane containing the global centroid (mean of the distribution), which is ortogonal to the di...

  1. Liquid concentration distribution and planar interface instability at an abruptly changing pulling velocity in directional solidification

    Institute of Scientific and Technical Information of China (English)

    LI ShuangMing; FU HengZhi

    2007-01-01

    Liquid concentration distribution is seriously affected by an abruptly changing pulling velocity under directional solidification. Theoretical and numerical investigations indicate that at the pulling velocity jumping from V0 to V, the solidification system does not achieve the pulling velocity V immediately, and it goes through a non-steady-state transition zone. As the pulling velocity abruptly increases (V/V0 > 1), interface liquid concentration firstly increases to the maximum and then decreases to the steady-state value. The magnitude of interface liquid concentration at the beginning increases with V/V0, the initial pulling velocity V0 and the temperature gradient GL in the liquid. At the same time, solute diffusion length reduces with V/V0 and GL. In contrast, the minimum of interface liquid concentration falls with V/V0 at the pulling velocity decreasing abruptly. As the interface liquid concentration enriched at V/V0 > 1 is more than the value required for the planar interface to keep stable, the solid/liquid interface may become unstable. The analytical results are in agreement with the numerical calculation results of Al-2%Cu alloy.

  2. Liquid concentration distribution and planar interface instability at an abruptly changing pulling velocity in directional solidification

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Liquid concentration distribution is seriously affected by an abruptly changing pulling velocity under directional solidification. Theoretical and numerical investi-gations indicate that at the pulling velocity jumping from V0 to V, the solidification system does not achieve the pulling velocity V immediately, and it goes through a non-steady-state transition zone. As the pulling velocity abruptly increases (V/V0 > 1), interface liquid concentration firstly increases to the maximum and then de-creases to the steady-state value. The magnitude of interface liquid concentration at the beginning increases with V/V0, the initial pulling velocity V0 and the tem-perature gradient GL in the liquid. At the same time, solute diffusion length reduces with V/V0 and GL. In contrast, the minimum of interface liquid concentration falls with V/V0 at the pulling velocity decreasing abruptly. As the interface liquid con-centration enriched at V/V0 > 1 is more than the value required for the planar inter-face to keep stable, the solid/liquid interface may become unstable. The analytical results are in agreement with the numerical calculation results of Al-2%Cu alloy.

  3. Velocity Distribution Measurement Using Pixel-Pixel Cross Correlation of Electrical Tomography

    Institute of Scientific and Technical Information of China (English)

    DENGXiang; PENGLihui; YAODanya; ZHANGBaofen

    2004-01-01

    Electrical tomography (ET) provides a novel means of visualizing the internal behavior of twophase flow in industrial process. Using a dual-sensingplane Electrical resistance tomography (ERT) or Electrical capacitance tomography (ECT) system, the raw data of two different section images can be acquired synchronously and the two images reflecting the inner medium distribution respectively can also be reconstructed by using imaging algorithm. Further, the analysis of pixel-pixel cross correlation is able to be setup and the measurement of velocity distribution of two-phase flow could be achieved. The principle is described in the paper. The FFT algorithm for gray value computation and cross correlation function calculation is also introduced. Some experimental results of velocity distribution measurement using pixelpixel cross correlation in vertical slug flow are presented.

  4. Velocity distributions of hydrogen atoms and hydroxyl radicals produced through solar photodissociation of water

    Science.gov (United States)

    Wu, C. Y. R.; Chen, F. Z.

    1993-01-01

    The velocity distributions of H and OH fragments produced through solar photodissociation of gaseous H2O molecules under collisionless conditions are presented. The calculations are carried out using: the most recently available absolute partial cross sections for the production of H and OH through photodissociation of H2O from its absorption onset at 1860 A down to 500 A; the newly available vibrational and rotational energy distributions of both the excited and ground state OH photofragments; the calculated cross sections for the total dissociation processes; and the integrated solar flux in 10 A increments from 500 to 1860 A in the continuum regions and the specific wavelength and flux at the bright solar lines. The calculated results show that the H atoms and the OH radicals produced exhibit multiple velocity groups. Since most current cometary modeling uses a single velocity of 20 km/sec associated with the photodissociation of H2O, the present results may be useful in interpreting the many peaks observed in the velocity distributions of the H Lyman alpha and H alpha of comets.

  5. Motor Axon Pathfinding

    OpenAIRE

    Bonanomi, Dario; Pfaff, Samuel L

    2010-01-01

    Motor neurons are functionally related, but represent a diverse collection of cells that show strict preferences for specific axon pathways during embryonic development. In this article, we describe the ligands and receptors that guide motor axons as they extend toward their peripheral muscle targets. Motor neurons share similar guidance molecules with many other neuronal types, thus one challenge in the field of axon guidance has been to understand how the vast complexity of brain connection...

  6. Distributed optical fiber-based theoretical and empirical methods monitoring hydraulic engineering subjected to seepage velocity

    Science.gov (United States)

    Su, Huaizhi; Tian, Shiguang; Cui, Shusheng; Yang, Meng; Wen, Zhiping; Xie, Wei

    2016-09-01

    In order to systematically investigate the general principle and method of monitoring seepage velocity in the hydraulic engineering, the theoretical analysis and physical experiment were implemented based on distributed fiber-optic temperature sensing (DTS) technology. During the coupling influence analyses between seepage field and temperature field in the embankment dam or dike engineering, a simplified model was constructed to describe the coupling relationship of two fields. Different arrangement schemes of optical fiber and measuring approaches of temperature were applied on the model. The inversion analysis idea was further used. The theoretical method of monitoring seepage velocity in the hydraulic engineering was finally proposed. A new concept, namely the effective thermal conductivity, was proposed referring to the thermal conductivity coefficient in the transient hot-wire method. The influence of heat conduction and seepage could be well reflected by this new concept, which was proved to be a potential approach to develop an empirical method monitoring seepage velocity in the hydraulic engineering.

  7. Late Quaternary climate-change velocity: Implications for modern distributions and communities

    DEFF Research Database (Denmark)

    Sandel, Brody Steven; Dalsgaard, Bo; Arge, Lars Allan; Svenning, J.-C.

    Background/Question/Methods Climate-change velocity is a measure of the rate of climate change that incorporates small-scale climate variation such as that found along topographic gradients. As a measure of climate instability, it has several advantages, including describing the minimum migration...... rate required to track changing conditions and explicitly capturing the buffering effect of topography on climate change. Variation in climate stability has long been hypothesized as a possible driver of large-scale ecological patterns including diversity and range size gradients. We calculated a...... global map of climate-change velocity since the Last Glacial Maximum and used this measure of climate instability to address a number of classic hypotheses. Results/Conclusions We show that historical climate-change velocity is related to a wide range of characteristics of modern distributions and...

  8. Precision measurement of transverse velocity distribution of a strontium atomic beam

    Directory of Open Access Journals (Sweden)

    F. Gao

    2014-02-01

    Full Text Available We measure the transverse velocity distribution in a thermal Sr atomic beam precisely by velocity-selective saturated fluorescence spectroscopy. The use of an ultrastable laser system and the narrow intercombination transition line of Sr atoms mean that the resolution of the measured velocity can reach 0.13 m/s, corresponding to 90 μK in energy units. The experimental results are in very good agreement with the results of theoretical calculations. Based on the spectroscopic techniques used here, the absolute frequency of the intercombination transition of 88Sr is measured using an optical-frequency comb generator referenced to the SI second through an H maser, and is given as 434 829 121 318(10 kHz.

  9. Precision measurement of transverse velocity distribution of a strontium atomic beam

    Energy Technology Data Exchange (ETDEWEB)

    Gao, F.; Liu, H.; Tian, X. [CAS Key Laboratory of Time and Frequency Primary Standards, National Time Service Center, Xi' an 710600 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Xu, P.; Wang, Y.; Ren, J. [CAS Key Laboratory of Time and Frequency Primary Standards, National Time Service Center, Xi' an 710600 (China); Wu, Haibin, E-mail: hbwu@phy.ecnu.edu.cn [State Key Laboratory of Precision Spectroscopy, Department of Physics, East China Normal University, Shanghai 200062 (China); Chang, Hong, E-mail: changhong@ntsc.ac.cn [CAS Key Laboratory of Time and Frequency Primary Standards, National Time Service Center, Xi' an 710600 (China); State Key Laboratory of Precision Spectroscopy, Department of Physics, East China Normal University, Shanghai 200062 (China)

    2014-02-15

    We measure the transverse velocity distribution in a thermal Sr atomic beam precisely by velocity-selective saturated fluorescence spectroscopy. The use of an ultrastable laser system and the narrow intercombination transition line of Sr atoms mean that the resolution of the measured velocity can reach 0.13 m/s, corresponding to 90 μK in energy units. The experimental results are in very good agreement with the results of theoretical calculations. Based on the spectroscopic techniques used here, the absolute frequency of the intercombination transition of {sup 88}Sr is measured using an optical-frequency comb generator referenced to the SI second through an H maser, and is given as 434 829 121 318(10) kHz.

  10. Lateral distributions of streamwise velocity in compound channels with partially vegetated floodplains

    Institute of Scientific and Technical Information of China (English)

    TANG XiaoNan; KNIGHT Donald W

    2009-01-01

    Natural rivers are commonly characterized by a main channel for primary flow conveyance and a floodplain, often partially covered with vegetation such as shrubs or trees, to carry extra flow during floods.The hydraulic resistance due to vegetation on the floodplain typically causes a further reduction of flow velocity and increases the velocity difference between the main channel and the floodplain.As a consequence a strong lateral shear layer leads to the exchange of mass and momentum between the main channel and floodplain, which in turn affects the overall channel conveyance and certain fluvial processes.The prediction of the lateral velocity distribution is important for many flood alleviation schemes, as well as for studies on sediment transport and dispersion in such channels.The present paper proposes a method for predicting the depth-averaged velocity in compound channels with par-tially vegetated floodplains, based on an analytical solution to the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term included to account for the effects of vegetation.The vegetation is modelled via an additional term in the momentum equation to account for the additional drag force.The method includes the effects of bed friction, drag force, lateral turbulence and secondary flows, via four coefficients f, C_D,λ & Г respectively.The predicted lateral distributions of depth-averaged velocity agree well with the experimental data.The analytical solutions can also be used to predict the distribu-tion of boundary shear stresses, which adds additional weight to the method proposed.

  11. Protein 4.1B contributes to the organization of peripheral myelinated axons.

    Directory of Open Access Journals (Sweden)

    Carmen Cifuentes-Diaz

    Full Text Available Neurons are characterized by extremely long axons. This exceptional cell shape is likely to depend on multiple factors including interactions between the cytoskeleton and membrane proteins. In many cell types, members of the protein 4.1 family play an important role in tethering the cortical actin-spectrin cytoskeleton to the plasma membrane. Protein 4.1B is localized in myelinated axons, enriched in paranodal and juxtaparanodal regions, and also all along the internodes, but not at nodes of Ranvier where are localized the voltage-dependent sodium channels responsible for action potential propagation. To shed light on the role of protein 4.1B in the general organization of myelinated peripheral axons, we studied 4.1B knockout mice. These mice displayed a mildly impaired gait and motility. Whereas nodes were unaffected, the distribution of Caspr/paranodin, which anchors 4.1B to the membrane, was disorganized in paranodal regions and its levels were decreased. In juxtaparanodes, the enrichment of Caspr2, which also interacts with 4.1B, and of the associated TAG-1 and Kv1.1, was absent in mutant mice, whereas their levels were unaltered. Ultrastructural abnormalities were observed both at paranodes and juxtaparanodes. Axon calibers were slightly diminished in phrenic nerves and preterminal motor axons were dysmorphic in skeletal muscle. βII spectrin enrichment was decreased along the axolemma. Electrophysiological recordings at 3 post-natal weeks showed the occurrence of spontaneous and evoked repetitive activity indicating neuronal hyperexcitability, without change in conduction velocity. Thus, our results show that in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber.

  12. Vertical distribution of fluid velocity and suspended sediment in open channel turbulent flow

    Science.gov (United States)

    Pal, Debasish; Ghoshal, Koeli

    2016-06-01

    To predict the vertical distribution of streamwise fluid velocity and suspended sediment concentration profiles in an open channel turbulent flow, we derive a theoretical model here based on the Reynolds averaged Navier-Stokes equation and the mass conservation equations of solid and fluid phases. The model includes the effects of secondary current in terms of the vertical velocity of fluid, additional vertical velocity of fluid due to the suspended particles, mixing length of sediment-laden flow and settlement of the suspended particles due to gravitational force. We numerically solve our model as coupled differential equations and the obtained solution agrees well with a wide spectrum of experimental data. A detailed error analysis asserts the superior determination accuracy of our model in comparison to the traditional log-law and Rouse equation and other existing theoretical models. The significance of the turbulent features included in the model and the importance of their co-existence to compute velocity and concentration profiles are explained. In sharp contrast to the previous researchers, the present model has significant contribution in unveiling several latent phenomena of particle-turbulence interaction throughout the flow region. The model can also address various crucial phenomena of velocity and concentration profiles that occur during flow in real situation.

  13. The Velocity Distribution Function of Galaxy Clusters as a Cosmological Probe

    CERN Document Server

    Ntampaka, M; Cisewski, J; Price, L C

    2016-01-01

    We present a new approach for quantifying the abundance of galaxy clusters and constraining cosmological parameters using dynamical measurements. In the standard method, galaxy line-of-sight (LOS) velocities, $v$, or velocity dispersions are used to infer cluster masses, $M$, in order to quantify the halo mass function (HMF), $dn(M)/d\\log(M)$, which is strongly affected by mass measurement errors. In our new method, the probability distribution of velocities for each cluster in the sample are summed to create a new statistic called the velocity distribution function (VDF), $dn(v)/dv$. The VDF can be measured more directly and precisely than the HMF and it can also be robustly predicted with cosmological simulations which capture the dynamics of subhalos or galaxies. We apply these two methods to mock cluster catalogs and forecast the bias and constraints on the matter density parameter $\\Omega_m$ and the amplitude of matter fluctuations $\\sigma_8$ in flat $\\Lambda$CDM cosmologies. For an example observation o...

  14. Automated kymograph analysis for profiling axonal transport of secretory granules.

    Science.gov (United States)

    Mukherjee, Amit; Jenkins, Brian; Fang, Cheng; Radke, Richard J; Banker, Gary; Roysam, Badrinath

    2011-06-01

    This paper describes an automated method to profile the velocity patterns of small organelles (BDNF granules) being transported along a selected section of axon of a cultured neuron imaged by time-lapse fluorescence microscopy. Instead of directly detecting the granules as in conventional tracking, the proposed method starts by generating a two-dimensional spatio-temporal map (kymograph) of the granule traffic along an axon segment. Temporal sharpening during the kymograph creation helps to highlight granule movements while suppressing clutter due to stationary granules. A voting algorithm defined over orientation distribution functions is used to refine the locations and velocities of the granules. The refined kymograph is analyzed using an algorithm inspired from the minimum set cover framework to generate multiple motion trajectories of granule transport paths. The proposed method is computationally efficient, robust to significant levels of noise and clutter, and can be used to capture and quantify trends in transport patterns quickly and accurately. When evaluated on a collection of image sequences, the proposed method was found to detect granule movement events with 94% recall rate and 82% precision compared to a time-consuming manual analysis. Further, we present a study to evaluate the efficacy of velocity profiling by analyzing the impact of oxidative stress on granule transport in which the fully automated analysis correctly reproduced the biological conclusion generated by manual analysis. PMID:21330183

  15. Velocity and angular distributions of evaporation residues from /sup 32/S-induced reactions

    Energy Technology Data Exchange (ETDEWEB)

    Hinnefeld, J.D.; Kolata, J.J.; Henderson, D.J.; Janssens, R.V.F.; Kovar, D.G.; Lesko, K.T.; Rosner, G.; Stephans, G.S.F.; van den Berg, A.M.; Wilkins, B.D.

    1987-09-01

    Velocity distributions of mass-resolved evaporation residues from reactions of /sup 32/S with /sup 12/C, /sup 24/Mg, /sup 27/Al, /sup 28/Si, and /sup 40/Ca have been measured at bombarding energies of 194, 239, and 278 MeV using time-of-flight techniques. In all cases, the observed shifts in the velocity centroids relative to the values expected for complete fusion are consistent with a previously reported parametrization of a threshold for onset of incomplete fusion. Angular distributions were measured and total cross sections extracted for the /sup 32/S+ /sup 24/Mg system at all three energies. A comparison with existing results for /sup 32/S+ /sup 24/Mg at lower energies, and with other systems leading to the /sup 56/Ni compound nucleus, suggests two different types of compound-nuclear limitations to complete fusion at higher energies.

  16. Fluctuations in a plasma with the Lorentz distribution function on velocity

    International Nuclear Information System (INIS)

    Basic characteristics of an electron plasma with the Lorentz function of distribution over velocities have been obtained. Such a model permits obtaining rather simple analytical expressions for different values characterizing field oscillations. In some case (coulomb interaction energy, correlations of the charge density) the expressions coincide with the corresponding macwellian ones, in other cases (for instance, the dielectric constant) they have a more simple form. The oscillation increments have been obtained in the presence of a low-density electron flux also with the Lorentz distribution over velocities in plasma. It has been shown that primarily one should expect the build-up of the so-called resonance oscillations, the threshold value of the oscillations, the threshold value of the oscillation increment coinciding with the corresponding maxwellian one. For some examples oscillations near the stability boundary of a beam with an arbitrary density have been considered

  17. Study on Droplet Size and Velocity Distributions of a Pressure Swirl Atomizer Based on the Maximum Entropy Formalism

    Directory of Open Access Journals (Sweden)

    Kai Yan

    2015-01-01

    Full Text Available A predictive model for droplet size and velocity distributions of a pressure swirl atomizer has been proposed based on the maximum entropy formalism (MEF. The constraint conditions of the MEF model include the conservation laws of mass, momentum, and energy. The effects of liquid swirling strength, Weber number, gas-to-liquid axial velocity ratio and gas-to-liquid density ratio on the droplet size and velocity distributions of a pressure swirl atomizer are investigated. Results show that model based on maximum entropy formalism works well to predict droplet size and velocity distributions under different spray conditions. Liquid swirling strength, Weber number, gas-to-liquid axial velocity ratio and gas-to-liquid density ratio have different effects on droplet size and velocity distributions of a pressure swirl atomizer.

  18. Angular velocity distribution of a granular planar rotator in a thermalized bath

    OpenAIRE

    Piasecki, J.; Talbot, J.; Viot, P.

    2006-01-01

    The kinetics of a granular planar rotator with a fixed center undergoing inelastic collisions with bath particles is analyzed both numerically and analytically by means of the Boltzmann equation. The angular velocity distribution evolves from quasi-gaussian in the Brownian limit to an algebraic decay in the limit of an infinitely light particle. In addition, we compare this model with a planar rotator with a free center. We propose experimental tests that might confirm the predicted behaviors.

  19. Angular velocity distribution of a granular planar rotator in a thermalized bath.

    Science.gov (United States)

    Piasecki, J; Talbot, J; Viot, P

    2007-05-01

    The kinetics of a granular planar rotator with a fixed center undergoing inelastic collisions with bath particles is analyzed both numerically and analytically by means of the Boltzmann equation. The angular velocity distribution evolves from quasi-Gaussian in the Brownian limit to an algebraic decay in the limit of an infinitely light particle. In addition, we compare this model to that of a planar rotator with a free center and discuss the prospects for experimental confirmation of these results. PMID:17677054

  20. Axon Membrane Skeleton Structure is Optimized for Coordinated Sodium Propagation

    CERN Document Server

    Zhang, Yihao; Li, He; Tzingounis, Anastasios V; Lykotrafitis, George

    2016-01-01

    Axons transmit action potentials with high fidelity and minimal jitter. This unique capability is likely the result of the spatiotemporal arrangement of sodium channels along the axon. Super-resolution microscopy recently revealed that the axon membrane skeleton is structured as a series of actin rings connected by spectrin filaments that are held under entropic tension. Sodium channels also exhibit a periodic distribution pattern, as they bind to ankyrin G, which associates with spectrin. Here, we elucidate the relationship between the axon membrane skeleton structure and the function of the axon. By combining cytoskeletal dynamics and continuum diffusion modeling, we show that spectrin filaments under tension minimize the thermal fluctuations of sodium channels and prevent overlap of neighboring channel trajectories. Importantly, this axon skeletal arrangement allows for a highly reproducible band-like activation of sodium channels leading to coordinated sodium propagation along the axon.

  1. Aerosol formation from high-velocity uranium drops: Comparison of number and mass distributions. Final report

    International Nuclear Information System (INIS)

    This report presents the results of an experimental study of the aerosol produced by the combustion of high-velocity molten-uranium droplets produced by the simultaneous heating and electromagnetic launch of uranium wires. These tests are intended to simulate the reduction of high-velocity fragments into aerosol in high-explosive detonations or reactor accidents involving nuclear materials. As reported earlier, the resulting aerosol consists mainly of web-like chain agglomerates. A condensation nucleus counter was used to investigate the decay of the total particle concentration due to coagulation and losses. Number size distributions based on mobility equivalent diameter obtained soon after launch with a Differential Mobility Particle Sizer showed lognormal distributions with an initial count median diameter (CMD) of 0.3 μm and a geometric standard deviation, σg of about 2; the CMD was found to increase and σg decrease with time due to coagulation. Mass size distributions based on aerodynamic diameter were obtained for the first time with a Microorifice Uniform Deposit Impactor, which showed lognormal distributions with mass median aerodynamic diameters of about 0.5 μm and an aerodynamic geometric standard deviation of about 2. Approximate methods for converting between number and mass distributions and between mobility and aerodynamic equivalent diameters are presented

  2. Longitudinal electron waves for a plasma with a bi-Maxwellian velocity distribution

    International Nuclear Information System (INIS)

    An original method for calculating and representing the excitation coefficients of longitudinal electron waves is applied to the case of a hot, collisionless, homogeneous and isotropic plasma with a bi-Maxwellian velocity distribution function. Using a Van Kampen treatment a 'wave density' distribution is represented graphically. When hot electrons are added to a plasma of cool electrons the Landau mode is distorted and its damping increases with the hot/cold temperature ratio theta. The Landau mode separates into two modes for theta >= theta0 where theta0 increases as the hot/cold density ratio α decreases. It is shown that no wave seems to be able to propagate at frequencies below the plasma frequency. Using an abrupt cut-off in the hot electron distribution function, we recover the results for a Maxwellian plus water-bag distribution. (author)

  3. Analysis of the Velocity Distribution in Partially-Filled Circular Pipe Employing the Principle of Maximum Entropy

    Science.gov (United States)

    2016-01-01

    The flow velocity distribution in partially-filled circular pipe was investigated in this paper. The velocity profile is different from full-filled pipe flow, since the flow is driven by gravity, not by pressure. The research findings show that the position of maximum flow is below the water surface, and varies with the water depth. In the region of near tube wall, the fluid velocity is mainly influenced by the friction of the wall and the pipe bottom slope, and the variation of velocity is similar to full-filled pipe. But near the free water surface, the velocity distribution is mainly affected by the contractive tube wall and the secondary flow, and the variation of the velocity is relatively small. Literature retrieval results show relatively less research has been shown on the practical expression to describe the velocity distribution of partially-filled circular pipe. An expression of two-dimensional (2D) velocity distribution in partially-filled circular pipe flow was derived based on the principle of maximum entropy (POME). Different entropies were compared according to fluid knowledge, and non-extensive entropy was chosen. A new cumulative distribution function (CDF) of partially-filled circular pipe velocity in terms of flow depth was hypothesized. Combined with the CDF hypothesis, the 2D velocity distribution was derived, and the position of maximum velocity distribution was analyzed. The experimental results show that the estimated velocity values based on the principle of maximum Tsallis wavelet entropy are in good agreement with measured values. PMID:26986064

  4. Probing the local velocity distribution of WIMP dark matter with directional detectors

    International Nuclear Information System (INIS)

    We explore the ability of directional nuclear-recoil detectors to constrain the local velocity distribution of weakly interacting massive particle (WIMP) dark matter by performing Bayesian parameter estimation on simulated recoil-event data sets. We discuss in detail how directional information, when combined with measurements of the recoil-energy spectrum, helps break degeneracies in the velocity-distribution parameters. We also consider the possibility that velocity structures such as cold tidal streams or a dark disk may also be present in addition to the Galactic halo. Assuming a CF4 detector with a 30-kg-yr exposure, a 50-GeV WIMP mass, and a WIMP-nucleon spin-dependent cross-section of 10−3pb, we show that the properties of a cold tidal stream may be well constrained. However, measurement of the parameters of a dark-disk component with a low lag speed of ∼ 50km/s may be challenging unless energy thresholds are improved

  5. High-resolution in-situ LDV monitoring system for measuring velocity distribution in blood vessel

    Science.gov (United States)

    Kyoden, Tomoaki; Abe, Shotaro; Ishida, Hiroki; Akiguchi, Shunsuke; Andoh, Tsugunobu; Takada, Yogo; Teranishi, Tsunenobu; Hachiga, Tadashi

    2015-10-01

    We herein describe a cross-sectional multiple-point laser Doppler velocimetry (CS-MLDV) system for monitoring blood vessels that are sutured and connected during an operation. In order to observe the condition of a blood vessel during an operation, the previously developed linear MLDV (L-MLDV) system can realize velocity distribution imaging of the carotid artery in a living mouse by means of traverse laser light. We subsequently developed a CS-MLDV system, which can measure the instantaneous two-dimensional (2D) flow velocity, by upgrading the optical components and signal processing used in L-MLDV. The validity of the CS-MLDV results was verified through comparison with the results of a computational fluid dynamics (CFD) analysis. The results of the CFD analysis were similar to the experimental results obtained under the same flow field condition. Moreover, an instantaneous 2D velocity distribution can be obtained even for the case of flowing blood. Finally, we carried out in-vivo measurement in a mesenteric vessel of a mouse in order to demonstrate the potential of the CS-MLDV for use in surgery.

  6. Relative velocity distribution of inertial particles in turbulence: A numerical study

    Science.gov (United States)

    Perrin, Vincent E.; Jonker, Harm J. J.

    2015-10-01

    The distribution of relative velocities between particles provides invaluable information on the rates and characteristics of particle collisions. We show that the theoretical model of Gustavsson and Mehlig [K. Gustavsson and B. Mehlig, J. Turbul. 15, 34 (2014), 10.1080/14685248.2013.875188], within its anticipated limits of validity, can predict the joint probability density function of relative velocities and separations of identical inertial particles in isotropic turbulent flows with remarkable accuracy. We also quantify the validity range of the model. The model matches two limits (or two types) of relative motion between particles: one where pair diffusion dominates (i.e., large coherence between particle motion) and one where caustics dominate (i.e., large velocity differences between particles at small separations). By using direct numerical simulation combined with Lagrangian particle tracking, we assess the model prediction in homogeneous and isotropic turbulence. We demonstrate that, when sufficient caustics are present at a given separation and the particle response time is significantly smaller than the integral time scales of the flow, the distribution exhibits the same universal power-law form dictated by the correlation dimension as predicted by the model of Gustavsson and Mehlig. In agreement with the model, no strong dependency on the Taylor-based Reynolds number is observed.

  7. The velocity distribution of pickup He{sup +} measured at 0.3 AU by MESSENGER

    Energy Technology Data Exchange (ETDEWEB)

    Gershman, Daniel J. [Geospace Physics Laboratory, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Fisk, Lennard A.; Gloeckler, George; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H. [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Solomon, Sean C., E-mail: djgersh@umich.edu [Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, DC 20015 (United States)

    2014-06-20

    During its interplanetary trajectory in 2007-2009, the MErcury Surface, Space ENvrionment, GEochemistry, and Ranging (MESSENGER) spacecraft passed through the gravitational focusing cone for interstellar helium multiple times at a heliocentric distance R ≈ 0.3 AU. Observations of He{sup +} interstellar pickup ions made by the Fast Imaging Plasma Spectrometer sensor on MESSENGER during these transits provide a glimpse into the structure of newly formed inner heliospheric pickup-ion distributions. This close to the Sun, these ions are picked up in a nearly radial interplanetary magnetic field. Compared with the near-Earth environment, pickup ions observed near 0.3 AU will not have had sufficient time to be energized substantially. Such an environment results in a nearly pristine velocity distribution function that should depend only on pickup-ion injection velocities (related to the interstellar gas), pitch-angle scattering, and cooling processes. From measured energy-per-charge spectra obtained during multiple spacecraft observational geometries, we have deduced the phase-space density of He{sup +} as a function of magnetic pitch angle. Our measurements are most consistent with a distribution that decreases nearly monotonically with increasing pitch angle, rather than the more commonly modeled isotropic or hemispherically symmetric forms. These results imply that pitch-angle scattering of He{sup +} may not be instantaneous, as is often assumed, and instead may reflect the velocity distribution of initially injected particles. In a slow solar wind stream, we find a parallel-scattering mean free path of λ {sub ||} ∼ 0.1 AU and a He{sup +} production rate of ∼0.05 m{sup –3} s{sup –1} within 0.3 AU.

  8. Bayesian reconstruction of the velocity distribution of weakly interacting massive particles from direct dark matter detection data

    International Nuclear Information System (INIS)

    In this paper, we extended our earlier work on the reconstruction of the (time-averaged) one-dimensional velocity distribution of Galactic Weakly Interacting Massive Particles (WIMPs) and introduce the Bayesian fitting procedure to the theoretically predicted velocity distribution functions. In this reconstruction process, the (rough) velocity distribution reconstructed by using raw data from direct Dark Matter detection experiments directly, i.e. measured recoil energies, with one or more different target materials, has been used as ''reconstructed-input'' information. By assuming a fitting velocity distribution function and scanning the parameter space based on the Bayesian analysis, the astronomical characteristic parameters, e.g. the Solar and Earth's Galactic velocities, will be pinned down as the output results

  9. Velocity and temperature distributions of coal-slag layers on magnetohydrodynamic generators walls

    Science.gov (United States)

    Pian, C. C. P.; Smith, J. M.

    1977-01-01

    Approximate analytical expressions are derived for the velocity and temperature distributions in steady state coal slag deposits flowing over MHD generator walls. Effects of slag condensation and Joule heating are included in the analysis. The transport conditions and the slag temperature at the slag-gas interface are taken to be known parameters in the formulation. They are assumed to have been predetermined either experimentally or from the slag properties and the gas dynamic calculations of the free stream flow. The analysis assumes a power law velocity profile for the slag and accounts for the coupling between the energy and momentum conservation equations. Comparisons are made with the more exact numerical solutions to verify the accuracy of the results.

  10. Crossed molecular beam studies of unimolecular reaction dynamics. [Angular and velocity distributions

    Energy Technology Data Exchange (ETDEWEB)

    Buss, R.J.

    1979-04-01

    The study of seven radical-molecule reactions using the crossed molecular beam technique with supersonic nozzle beams is reported. Product angular and velocity distributions were obtained and compared with statistical calculations in order to identify dynamical features of the reactions. In the reaction of chlorine and fluorine atoms with vinyl bromide, the product energy distributions are found to deviate from predictions of the statistical model. A similar effect is observed in the reaction of chlorine atoms with 1, 2 and 3-bromopropene. The reaction of oxygen atoms with ICl and CF/sub 3/I has been used to obtain an improved value of the IO bond energy, 55.0 +- 2.0 kcal mol/sup -1/. In all reactions studied, the product energy and angular distributions are found to be coupled, and this is attributed to a kinematic effect of the conservation of angular momentum.

  11. Observations of the He+ pickup ion torus velocity distribution function with SOHO/CELIAS/CTOF

    Science.gov (United States)

    Taut, Andreas; Berger, Lars; Bochsler, Peter; Drews, Christian; Klecker, Berndt; Wimmer-Schweingruber, Robert F.

    2016-03-01

    Interstellar PickUp Ions (PUIs) are created from neutrals coming from the interstellar medium that get ionized inside the heliosphere. Once ionized, the freshly created ions are injected into the magnetized solar wind plasma with a highly anisotropic torus-shaped Velocity Distribution Function (VDF). It has been commonly assumed that wave-particle interactions rapidly destroy this torus by isotropizing the distribution in one hemisphere of velocity space. However, recent observations of a He+ torus distribution using PLASTIC on STEREO showed that the assumption of a rapid isotropization is oversimplified. The aim of this work is to complement these studies. Using He+ data from the Charge Time-Of-Flight (CTOF) sensor of the Charge, ELement, and Isotope Analysis System (CELIAS) on-board the SOlar and Heliospheric Observatory (SOHO) and magnetic field data from the Magnetic Field Investigation (MFI) magnetometer of the WIND spacecraft, we derive the projected 1-D VDF of He+ for different magnetic field configurations. Depending on the magnetic field direction, the initial torus VDF lies inside CTOF's aperture or not. By comparing the VDFs derived under different magnetic field directions with each other we reveal an anisotropic signature of the He+ VDF.

  12. Ion Bernstein waves in a plasma with a kappa velocity distribution

    International Nuclear Information System (INIS)

    Using a Vlasov-Poisson model, a numerical investigation of the dispersion relation for ion Bernstein waves in a kappa-distributed plasma has been carried out. The dispersion relation is found to depend significantly on the spectral index of the ions, κi, the parameter whose smallness is a measure of the departure from thermal equilibrium of the distribution function. Over all cyclotron harmonics, the typical Bernstein wave curves are shifted to higher wavenumbers (k) if κi is reduced. For waves whose frequency lies above the lower hybrid frequency, ωLH, an increasing excess of superthermal particles (decreasing κi) reduces the frequency, ωpeak, of the characteristic peak at which the group velocity vanishes, while the associated kpeak is increased. As the ratio of ion plasma to cyclotron frequency (ωpi/ωci) is increased, the fall-off of ω at large k is smaller for lower κi and curves are shifted towards larger wavenumbers. In the lower hybrid frequency band and harmonic bands above it, the frequency in a low-κi plasma spans only a part of the intraharmonic space, unlike the Maxwellian case, thus exhibiting considerably less coupling between adjacent bands for low κi. It is suggested that the presence of the ensuing stopbands may be a useful diagnostic for the velocity distribution characteristics. The model is applied to the Earth's plasma sheet boundary layer in which waves propagating perpendicularly to the ambient magnetic field at frequencies between harmonics of the ion cyclotron frequency are frequently observed

  13. Neurofilament gene expression: a major determinant of axonal caliber

    International Nuclear Information System (INIS)

    Within the wide spectrum of axonal diameters occurring in mammalian nerve fibers, each class of neurons has a relatively restricted range of axonal calibers. The control of caliber has functional significance because diameter is the principal determinant of conduction velocity in myelinated nerve fibers. Previous observations support the hypothesis that neurofilaments (NF) are major intrinsic determinants of axonal caliber in large myelinated nerve fibers. Following interruption of axons (axotomy) by crushing or cutting a peripheral nerve, caliber is reduced in the proximal axonal stumps, which extend from the cell bodies to the site of axotomy. This reduction in axonal caliber in the proximal stumps is associated with a selective diminution in the amount of NF protein undergoing slow axonal transport in these axons, with a decrease in axonal NF content, and with reduced conduction velocity. The present report demonstrates that changes in axonal caliber after axotomy correlate with a selective alteration in NF gene expression. Hybridization with specific cDNAs was used to measure levels of mRNA encoding the 68-kDa neurofilament protein (NF68), β-tubulin, and actin in lumbar sensory neurons of rat at various times after crushing the sciatic nerve. Between 4 and 42 days after axotomy by nerve crush, the levels of NF68 mRNA were reduced 2- to 3-fold. At the same times, the levels of tubulin and actin mRNAs were increased several-fold. These findings support the hypothesis that the expression of a single set of neuron-specific genes (encoding NF) directly determines axonal caliber, a feature neuronal morphology with important consequences for physiology and behavior

  14. Superstatistical velocity distributions of cold trapped ions in molecular dynamics simulations

    CERN Document Server

    Rouse, I

    2015-01-01

    We present a realistic molecular-dynamics treatment of laser-cooled ions in radiofrequency ion traps which avoids previously made simplifications such as modeling laser cooling as a friction force and combining individual heating mechanisms into a single effective heating force. Based on this implementation, we show that infrequent energetic collisions of single ions with background gas molecules lead to pronounced heating of the entire ion ensemble and a time-varying secular ensemble temperature which manifests itself in a superstatistical time-averaged velocity distribution of the ions. The effect of this finding on the experimental determination of ion temperatures and rate constants for cold chemical reactions is discussed.

  15. Distribution of velocity gradients and rate of caustic formation in turbulent aerosols at finite Kubo numbers

    CERN Document Server

    Gustavsson, K

    2012-01-01

    In a one-dimensional model for a turbulent aerosol (inertial particles suspended in a random flow) we compute the distributions of particle-velocity gradients and the rate of caustic formation at finite but small Kubo numbers Ku, for arbitrary Stokes numbers St. Our results are consistent with those obtained earlier in the limit of small Ku and and large St, such that Ku^2 St remains constant. We show how finite-time correlations and non-ergodic effects influence the inertial-particle dynamics at finite but small Kubo numbers.

  16. Velocity-gradient probability distribution functions in a lagrangian model of turbulence

    International Nuclear Information System (INIS)

    The Recent Fluid Deformation Closure (RFDC) model of lagrangian turbulence is recast in path-integral language within the framework of the Martin–Siggia–Rose functional formalism. In order to derive analytical expressions for the velocity-gradient probability distribution functions (vgPDFs), we carry out noise renormalization in the low-frequency regime and find approximate extrema for the Martin–Siggia–Rose effective action. We verify, with the help of Monte Carlo simulations, that the vgPDFs so obtained yield a close description of the single-point statistical features implied by the original RFDC stochastic differential equations. (paper)

  17. The three-dimensional distributions of tangential velocity and total- temperature in vortex tubes

    DEFF Research Database (Denmark)

    Linderstrøm-Lang, C.U.

    1971-01-01

    turbulent energy equation. The method employed for the solution of this equation stresses the equivalence of the vortex tube to counter-current systems with transverse diffusion such as distillation columns and heat exchangers. An availability function is derived that permits the evaluation of vortex tube......The axial and radial gradients of the tangential velocity distribution are calculated from prescribed secondary flow functions on the basis of a zero-order approximation to the momentum equations developed by Lewellen. It is shown that secondary flow functions may be devised which meet pertinent...

  18. Simulations of Ion Velocity Distribution Functions Taken into Account Both Elastic and Charge Exchange Collisions

    CERN Document Server

    Wang, Huihui; Kaganovich, Igor D; Mustafaev, Alexander S

    2016-01-01

    Based on accurate representation of the He+-He differential angular scattering cross sections consisting of both elastic and charge exchange collisions, we performed detailed numerical simulations of the ion velocity distribution functions (IVDF) by Monte Carlo collision method (MCC). The results of simulations are validated by comparison with the experimental data of the mobility and the transverse diffusion. The IVDF simulation study shows that due to significant effect of scattering in elastic collisions IVDF cannot be separated into product of two independent IVDFs in the transverse and parallel to the electric field directions.

  19. Turbulence-Induced Relative Velocity of Dust Particles III: The Probability Distribution

    CERN Document Server

    Pan, Liubin; Scalo, John

    2014-01-01

    Motivated by its important role in the collisional growth of dust particles in protoplanetary disks, we investigate the probability distribution function (PDF) of the relative velocity of inertial particles suspended in turbulent flows. Using the simulation from our previous work, we compute the relative velocity PDF as a function of the friction timescales, tau_p1 and tau_p2, of two particles of arbitrary sizes. The friction time of particles included in the simulation ranges from 0.1 tau_eta to 54T_L, with tau_eta and T_L the Kolmogorov time and the Lagrangian correlation time of the flow, respectively. The relative velocity PDF is generically non-Gaussian, exhibiting fat tails. For a fixed value of tau_p1, the PDF is the fattest for equal-size particles (tau_p2~tau_p1), and becomes thinner at both tau_p2tau_p1. Defining f as the friction time ratio of the smaller particle to the larger one, we find that, at a given f in 1/2>T_L). These features are successfully explained by the Pan & Padoan model. Usin...

  20. Reconstructing the Velocity Distribution of WIMPs from Direct Dark Matter Detection Data

    CERN Document Server

    Drees, M; Drees, Manuel; Shan, Chung-Lin

    2007-01-01

    Weakly interacting massive particles (WIMPs) are one of the leading candidates for dark matter. Currently, the most promising method to detect many different WIMP candidates is the direct detection of the recoil energy deposited in a low--background laboratory detector due to elastic WIMP--nucleus scattering. So far the usual procedure has been to predict the event rate of direct detection of WIMPs based on some model(s) of the galactic halo. The aim of our work is to invert this process. That is, we study what future direct detection experiment can teach us about the WIMP halo. As the first step we consider a time--averaged recoil spectrum, assuming that no directional information exists. We develop a method to construct the (time--averaged) one--dimensional velocity distribution function from this spectrum. Moments of this function, such as the mean velocity and velocity dispersion of WIMPs, can also be obtained directly from the recoil spectrum. The only input needed in addition to a measured recoil spectr...

  1. Determinants of axonal regeneration

    OpenAIRE

    Frisén, J

    1997-01-01

    Axons often regrow to their targets and lost functions may be restored after an injury in the peripheral nervous system. In contrast, axonal regeneration is generally very limited after injuries in the central nervous system, and functional impairment is usually permanent. The regenerative capacity depends on intrinsic neuronal factors as weil as the interaction of neurons with other cells. Glial cells may, in different situations, either support or inhibit axo...

  2. Sensitivity bias in the mass-radius distribution from Transit Timing Variations and Radial Velocity measurements

    CERN Document Server

    Steffen, Jason H

    2015-01-01

    Motivated by recent discussions, both in private and in the literature, we use a Monte Carlo simulation of planetary systems to investigate sources of bias in determining the mass-radius distribution of exoplanets for the two primary techniques used to measure planetary masses---Radial Velocities (RVs) and Transit Timing Variations (TTVs). We assert that mass measurements derived from these two methods are comparably reliable---as the physics underlying their respective signals is well understood. Nevertheless, their sensitivity to planet mass varies with the properties of the planets themselves. We find that for a given planet size, the RV method tends to find planets with higher mass while the sensitivity of TTVs is more uniform. This ``sensitivity bias'' implies that a complete census of TTV systems is likely to yield a more robust estimate of the mass-radius distribution provided there are not important physical differences between planets near and far from mean-motion resonance. We discuss differences in...

  3. Distributed leader-follower flocking control for multi-agent dynamical systems with time-varying velocities

    NARCIS (Netherlands)

    Yu, Wenwu; Chen, Guanrong; Cao, Ming

    2010-01-01

    Using tools from algebraic graph theory and nonsmooth analysis in combination with ideas of collective potential functions, velocity consensus and navigation feedback, a distributed leader-follower flocking algorithm for multi-agent dynamical systems with time-varying velocities is developed where e

  4. Axonal transmission in the retina introduces a small dispersion of relative timing in the ganglion cell population response.

    Directory of Open Access Journals (Sweden)

    Günther Zeck

    Full Text Available BACKGROUND: Visual stimuli elicit action potentials in tens of different retinal ganglion cells. Each ganglion cell type responds with a different latency to a given stimulus, thus transforming the high-dimensional input into a temporal neural code. The timing of the first spikes between different retinal projection neurons cells may further change along axonal transmission. The purpose of this study is to investigate if intraretinal conduction velocity leads to a synchronization or dispersion of the population signal leaving the eye. METHODOLOGY/PRINCIPAL FINDINGS: We 'imaged' the initiation and transmission of light-evoked action potentials along individual axons in the rabbit retina at micron-scale resolution using a high-density multi-transistor array. We measured unimodal conduction velocity distributions (1.3±0.3 m/sec, mean ± SD for axonal populations at all retinal eccentricities with the exception of the central part that contains myelinated axons. The velocity variance within each piece of retina is caused by ganglion cell types that show narrower and slightly different average velocity tuning. Ganglion cells of the same type respond with similar latency to spatially homogenous stimuli and conduct with similar velocity. For ganglion cells of different type intraretinal conduction velocity and response latency to flashed stimuli are negatively correlated, indicating that differences in first spike timing increase (up to 10 msec. Similarly, the analysis of pair-wise correlated activity in response to white-noise stimuli reveals that conduction velocity and response latency are negatively correlated. CONCLUSION/SIGNIFICANCE: Intraretinal conduction does not change the relative spike timing between ganglion cells of the same type but increases spike timing differences among ganglion cells of different type. The fastest retinal ganglion cells therefore act as indicators of new stimuli for postsynaptic neurons. The intraretinal dispersion

  5. The ion velocity distribution of tokamak plasmas: Rutherford scattering at TEXTOR

    Energy Technology Data Exchange (ETDEWEB)

    Tammen, H.F.

    1995-01-10

    One of the most promising ways to gererate electricity in the next century on a large scale is nuclear fusion. In this process two light nuclei fuse and create a new nucleus with a smaller mass than the total mass of the original nuclei, the mass deficit is released in the form of kinetic energy. Research into this field has already been carried out for some decades now, and will have to continue for several more decades before a commercially viable fusion reactor can be build. In order to obtain fusion, fuels of extremely high temperatures are needed to overcome the repulsive force of the nuclei involved. Under these circumstances the fuel is fully ionized: it consists of ions and electrons and is in the plasma state. The problem of confining such a hot substance is solved by using strong magnetic fields. One specific magnetic configuration, in common use, is called the tokamak. The plasma in this machine has a toroidal, i.e. doughnut shaped, configuration. For understanding the physical processes which take place in the plasma, a good temporally and spatially resolved knowledge of both the ion and electron velocity distribution is required. The situation concerning the electrons is favourable, but this is not the case for the ions. To improve the existing knowledge of the ion velocity distribution in tokamak plasmas, a Rutherford scattering diagnostic (RUSC), designed and built by the FOM-Institute for Plasmaphysics `Rijnhuizen`, was installed at the TEXTOR tokamak in Juelich (D). The principle of the diagnostic is as follows. A beam of monoenergetic particles (30 keV, He) is injected vertically into the plasma. A small part of these particles collides elastically with the moving plasma ions. By determining the energy of a scattered beam particle under a certain angle (7 ), the initial velocity of the plasma ion in one direction can be computed. (orig./WL).

  6. The ion velocity distribution of tokamak plasmas: Rutherford scattering at TEXTOR

    International Nuclear Information System (INIS)

    One of the most promising ways to gererate electricity in the next century on a large scale is nuclear fusion. In this process two light nuclei fuse and create a new nucleus with a smaller mass than the total mass of the original nuclei, the mass deficit is released in the form of kinetic energy. Research into this field has already been carried out for some decades now, and will have to continue for several more decades before a commercially viable fusion reactor can be build. In order to obtain fusion, fuels of extremely high temperatures are needed to overcome the repulsive force of the nuclei involved. Under these circumstances the fuel is fully ionized: it consists of ions and electrons and is in the plasma state. The problem of confining such a hot substance is solved by using strong magnetic fields. One specific magnetic configuration, in common use, is called the tokamak. The plasma in this machine has a toroidal, i.e. doughnut shaped, configuration. For understanding the physical processes which take place in the plasma, a good temporally and spatially resolved knowledge of both the ion and electron velocity distribution is required. The situation concerning the electrons is favourable, but this is not the case for the ions. To improve the existing knowledge of the ion velocity distribution in tokamak plasmas, a Rutherford scattering diagnostic (RUSC), designed and built by the FOM-Institute for Plasmaphysics 'Rijnhuizen', was installed at the TEXTOR tokamak in Juelich (D). The principle of the diagnostic is as follows. A beam of monoenergetic particles (30 keV, He) is injected vertically into the plasma. A small part of these particles collides elastically with the moving plasma ions. By determining the energy of a scattered beam particle under a certain angle (7 ), the initial velocity of the plasma ion in one direction can be computed. (orig./WL)

  7. Discrete Step Sizes of Molecular Motors Lead to Bimodal Non-Gaussian Velocity Distributions under Force

    Science.gov (United States)

    Vu, Huong T.; Chakrabarti, Shaon; Hinczewski, Michael; Thirumalai, D.

    2016-08-01

    Fluctuations in the physical properties of biological machines are inextricably linked to their functions. Distributions of run lengths and velocities of processive molecular motors, like kinesin-1, are accessible through single-molecule techniques, but rigorous theoretical models for these probabilities are lacking. Here, we derive exact analytic results for a kinetic model to predict the resistive force (F )-dependent velocity [P (v )] and run length [P (n )] distribution functions of generic finitely processive molecular motors. Our theory quantitatively explains the zero force kinesin-1 data for both P (n ) and P (v ) using the detachment rate as the only parameter. In addition, we predict the F dependence of these quantities. At nonzero F , P (v ) is non-Gaussian and is bimodal with peaks at positive and negative values of v , which is due to the discrete step size of kinesin-1. Although the predictions are based on analyses of kinesin-1 data, our results are general and should hold for any processive motor, which walks on a track by taking discrete steps.

  8. A comparative quantitative assessment of axonal and dendritic mRNA transport in maturing hippocampal neurons.

    Directory of Open Access Journals (Sweden)

    Gunja K Pathak

    Full Text Available Translation of mRNA in axons and dendrites enables a rapid supply of proteins to specific sites of localization within the neuron. Distinct mRNA-containing cargoes, including granules and mitochondrial mRNA, are transported within neuronal projections. The distributions of these cargoes appear to change during neuronal development, but details on the dynamics of mRNA transport during these transitions remain to be elucidated. For this study, we have developed imaging and image processing methods to quantify several transport parameters that can define the dynamics of RNA transport and localization. Using these methods, we characterized the transport of mitochondrial and non-mitochondrial mRNA in differentiated axons and dendrites of cultured hippocampal neurons varying in developmental maturity. Our results suggest differences in the transport profiles of mitochondrial and non-mitochondrial mRNA, and differences in transport parameters at different time points, and between axons and dendrites. Furthermore, within the non-mitochondrial mRNA pool, we observed two distinct populations that differed in their fluorescence intensity and velocity. The net axonal velocity of the brighter pool was highest at day 7 (0.002±0.001 µm/s, mean ± SEM, raising the possibility of a presynaptic requirement for mRNA during early stages of synapse formation. In contrast, the net dendritic velocity of the brighter pool increased steadily as neurons matured, with a significant difference between day 12 (0.0013±0.0006 µm/s and day 4 (-0.003±0.001 µm/s suggesting a postsynaptic role for mRNAs in more mature neurons. The dim population showed similar trends, though velocities were two orders of magnitude higher than of the bright particles. This study provides a baseline for further studies on mRNA transport, and has important implications for the regulation of neuronal plasticity during neuronal development and in response to neuronal injury.

  9. Dynamics of axon fasciculation in the presence of neuronal turnover

    CERN Document Server

    Chaudhuri, Debasish; Mohanty, P K; Zapotocky, Martin

    2008-01-01

    We formulate and characterize a model aiming to describe the formation of fascicles of axons mediated by contact axon-axon interactions. The growing axons are represented as interacting directed random walks in two spatial dimensions. To mimic axonal turnover in the mammalian olfactory system, the random walkers are injected and removed at specified rates. In the dynamical steady state, the position-dependent distribution of fascicle sizes obeys a scaling law. We identify several distinct time scales that emerge from the dynamics, are sensitive functions of the microscopic parameters of the model, and can exceed the average axonal lifetime by orders of magnitude. We discuss our findings in terms of an analytically tractable, effective model of fascicle dynamics.

  10. The Effects of High-Velocity Supernova Kicks on the Orbital Properties and Sky Distributions of Neutron Star Binaries

    OpenAIRE

    Brandt, W. N.; Podsiadlowski, Ph.

    1994-01-01

    We systematically investigate the effects of high supernova kick velocities on the orbital parameters of post-supernova neutron-star binaries. Using Monte- Carlo simulations, we determine the post-supernova distributions of orbital parameters for progeneitors of HMXBs and LMXBs. With the recent distribution of pulsar birth velocities by Lyne & Lorimer (1994), only about 27% of massive systems remain bound after the supernova, of which about 26% immediately experience dynamical mass transfer a...

  11. Understanding the growth rate patterns of ion Bernstein instabilities driven by ring-like proton velocity distributions

    Science.gov (United States)

    Min, Kyungguk; Liu, Kaijun

    2016-04-01

    Fast magnetosonic waves in Earth's inner magnetosphere, which have as their source ion Bernstein instabilities, are driven by hot proton velocity distributions (fp) with ∂fp(v⊥)/∂v⊥>0. Two typical types of distributions with such features are ring and shell velocity distributions. Both have been used in studies of ion Bernstein instabilities and fast magnetosonic waves, but the differences between instabilities driven by the two types of distributions have not been thoroughly addressed. The present study uses linear kinetic theory to examine and understand these differences. It is found that the growth rate pattern is primarily determined by the cyclotron resonance condition and the structure of the velocity distribution in gyroaveraged velocity space. For ring-driven Bernstein instabilities, as the parallel wave number (k∥) increases, the discrete unstable modes approximately follow the corresponding proton cyclotron harmonic frequencies while they become broader in frequency space. At sufficiently large k∥, the neighboring discrete modes merge into a continuum. In contrast, for shell-driven Bernstein instabilities, the curved geometry of the shell velocity distribution in gyroaveraged velocity space results in a complex alternating pattern of growth and damping rates in frequency and wave number space and confines the unstable Bernstein modes to relatively small k∥. In addition, when k∥ increases, the unstable modes are no longer limited to the proton cyclotron harmonic frequencies. The local growth rate peak near an exact harmonic at small k∥ bifurcates into two local peaks on both sides of the harmonic when k∥ becomes large.

  12. Anisotropy of the He+, C+, N+, O+, and Ne+ pickup ion velocity distribution functions

    Science.gov (United States)

    Drews, C.; Berger, L.; Taut, A.; Wimmer-Schweingruber, R. F.

    2016-04-01

    Context. Interstellar and inner-source pickup ions (PUIs) are produced by the ionization of neutral atoms that originate either outside or inside the heliosphere. Just after ionization, the singly charged ions are picked up by the magnetized solar wind plasma and develop strong anisotropic toroidal features in their velocity distribution functions (VDF). As the plasma parcel moves outwards with the solar wind, the pickup ion VDF gets more and more affected by resonant wave-particle interactions, changing heliospheric conditions, and plasma drifts, which lead to a gradual isotropization of the pickup ion VDF. Past investigations of the pickup ion torus distribution were limited to He+ pickup ions at 1 astronomical unit (AU). Aims: The aim of this study is to quantify the state of anisotropy of the He+, C+, N+, O+, and Ne+ pickup ion VDF at 1 AU. Changes between the state of anisotropy between PUIs of different mass-per-charges can be used to estimate the significance of resonant wave-particle interactions for the isotropization of their VDF, and to investigate the numerous simplifications that are generally made for the description of the phase-space transport of PUIs. Methods: Pulse height analysis data by the PLAsma and SupraThermal Ion Composition instrument (PLASTIC) on board the Solar Terrestrial RElations Observatory Ahead (STEREO A) is used to obtain velocity-spectra of He+, C+, N+, O+, and Ne+ relative to the solar wind, f(wsw). The wsw-spectra are sorted by two different configurations of the local magnetic field - one in which the torus distribution lies within the instrument's aperture, φ⊥, and one in which the torus distribution lies exclusively outside the instrument's field of view, φ∥. The ratio of the PUI spectra between φ⊥ and φ∥ is used to determine the degree of anisotropy of the PUI VDF. Results: The data shows that the formation of a torus distribution at 1 AU is significantly more prominent for O+ (and N+) than for He+ (and Ne

  13. Characteristics of proton velocity distribution functions in the near-lunar wake from Chandrayaan-1/SWIM observations

    Science.gov (United States)

    Dhanya, M. B.; Bhardwaj, Anil; Futaana, Yoshifumi; Barabash, Stas; Alok, Abhinaw; Wieser, Martin; Holmström, Mats; Wurz, Peter

    2016-06-01

    Due to the high absorption of solar wind plasma on the lunar dayside, a large scale wake structure is formed downstream of the Moon. However, recent in-situ observations have revealed the presence of protons in the near-lunar wake (100 km to 200 km from the surface). The solar wind, either directly or after interaction with the lunar surface (including magnetic anomalies), is the source of these protons in the near-wake region. Using the entire data from the SWIM sensor of the SARA experiment onboard Chandrayaan-1, we analyzed the velocity distribution of the protons observed in the near-lunar wake. The average velocity distribution functions, computed in the solar wind rest frame, were further separated based on the angle between the upstream solar wind velocity and the IMF. Although the protons enter the wake parallel as well as perpendicular to the IMF, the velocity distribution were not identical for the different IMF orientations, indicating the control of IMF in the proton entry processes. Several proton populations were identified from the velocity distribution and their possible entry mechanism were inferred based on the characteristics of the velocity distribution. These entry mechanisms include (i) diffusion of solar wind protons into the wake along IMF, (ii) the solar wind protons with finite gyro-radii that are aided by the wake boundary electric field, (iii) solar wind protons with gyro-radii larger than lunar radii from the tail of the solar wind velocity distribution, and (iv) scattering of solar wind protons from the dayside lunar surface or from magnetic anomalies. In order to gain more insight into the entry mechanisms associated with different populations, backtracing is carried out for each of these populations. For most of the populations, the source of the protons obtained from backtracing is found to be in agreement with that inferred from the velocity distribution. There are few populations that could not be explained by the known mechanisms

  14. Experimental study of the spatial distribution of the velocity field of sedimenting particles: mean velocity, pseudo-turbulent fluctuations, intrinsic convection

    International Nuclear Information System (INIS)

    This work follows previous experiments from Nicolai et al. (95), Peysson and Guazzelli (98) and Segre et al. (97), which consisted in measures of the velocity of particles sedimenting in a liquid at low particular Reynolds numbers. Our goal, introduced in the first part with a bibliographic study, is to determinate the particles velocity fluctuations properties. The fluctuations are indeed of the same order as the mean velocity. We are proceeding with PIV Eulerian measures. The method is described in the second part. Its originality comes from measures obtained in a thin laser light sheet, from one side to the other of the cells, with a square section: the measures are therefore spatially localised. Four sets of cells and three sets of particles were used, giving access to ratios 'cell width over particle radius' ranging from about 50 up to 800. In the third part, we present the results concerning the velocity fluctuations structure and their spatial distribution. The intrinsic convection between to parallel vertical walls is also studied. The velocity fluctuations are organised in eddy structures. Their size (measured with correlation length) is independent of the volume fraction, contradicting the results of Segre et al. (97). The results concerning the velocity fluctuations spatial profiles - from one side to the other of the cell - confirm those published by Peysson and Guazzelli (98) in the case of stronger dilution. The evolution of the spatial mean velocity fluctuations confirms the results obtained by Segre et al. (97). The intrinsic convection is also observed in the case of strong dilutions. (author)

  15. Transport Equations of Three-point Distribution Functions in MHD Turbulent Flow for Velocity, Magnetic Temperature and Concentration

    Directory of Open Access Journals (Sweden)

    M.A.K. Azad

    2014-06-01

    Full Text Available In this study, the statistical theory of certain distribution functions for simultaneous velocity, magnetic temperature and concentration fields in MHD turbulent flow have been studied. The various properties of the constructed joint distribution functions such as, reduction property, separation property, coincidence and symmetric properties have been discussed. We have made an attempt to derive the transport equations for two and three point distribution functions. Lastly, the transport equation for evaluation of three point distribution functions has been derived.

  16. Determination of cosmic bodies size-velocity distribution by observation of current impacts on Mars

    Science.gov (United States)

    Nemchinov, I. V.; Perelomova, A. A.; Shuvalov, V. V.

    1993-01-01

    Collisions of cosmic bodies with terrestrial planets involve many physical processes such as deceleration and ablation during their flight through an atmosphere, the impact at a surface accompanied by cratering, melting and evaporation of surface material, generation of shock waves, etc. If body velocity is high enough then a thermal radiation is very important. All these processes on Mars proceed differently than on the other planets because of the low density of its atmosphere. In particular, this leads to the fact that smaller bodies of sizes of the order of 0.1-10 m strike the planet surface without being decelerated and perform some effects which may be detected by equipment placed on a board of artificial satellites, by a network of stations at the surface of Mars and even from the Earth. These observations can be used to determine size-velocity distribution of such bodies in the Solar System. Numerical simulation of the impacts at the surface of Mars have been carried out using two-dimensional gas dynamic code with detailed consideration of the thermal radiative transfer. This work is an extension of our previous paper. We have expanded a range of projectile sizes up to r sub 0 = 100 m. For such a large-scale body, the initial stage of the impact, involving crate ring and ejection of surface material, is very important. Thus, these effects have been taken into account.

  17. Kr II and Xe II axial velocity distribution functions in a cross-field ion source

    International Nuclear Information System (INIS)

    Laser induced fluorescence measurements were carried out in a cross-field ion source to examine the behaviour of the axial ion velocity distribution functions (VDFs) in the expanding plasma. In the present paper, we focus on the axial VDFs of Kr II and Xe II ions. We examine the contourplots in a 1D-phase space (x,vx) representation in front of the exhaust channel and along the centerline of the ion source. The main ion beam, whose momentum corresponds to the ions that are accelerated through the whole potential drop, is observed. A secondary structure reveals the ions coming from the opposite side of the channel. We show that the formation of the neutralized ion flow is governed by the annular geometry. The assumption of a collisionless shock or a double layer due to supersonic beam interaction is not necessary. A non-negligible fraction of slow ions originates in local ionization or charge-exchange collision events between ions of the expanding plasma and atoms of the background residual gas. Slow ions that are produced near the centerline in the vicinity of the exit plane are accelerated toward the source body with a negative velocity leading to a high sputtering of front face. On the contrary, the ions that are produced in the vicinity of the channel exit plane are partially accelerated by the extended electric field.

  18. Systematic Variability of the He+ Pickup Ion Velocity Distribution Function Observed With SOHO/CELIAS/CTOF

    Science.gov (United States)

    Taut, Andreas; Wimmer-Schweingruber, Robert; Berger, Lars; Drews, Christian

    2016-07-01

    Interstellar pickup ions in the heliosphere exhibit a characteristic suprathermal Velocity Distribution Function (VDF). This is the result of their injection into the solar wind as a highly anisotropic torus distribution which is continuously modulated by pitch-angle scattering and cooling processes. As the impact of these processes on the pickup ion VDF depends on present and past solar wind conditions, the pickup ion VDF is not static but variable in shape and intensity. Using the good counting statistics of the Charge-Time-Of-Flight sensor onboard SOHO we were able to resolve a systematic variability of the He^+ VDF. On the one hand the intensity of freshly created pickup ions near the injection speed increases during magnetic field configurations in which the initial torus distribution lies inside the sensor's aperture. This complements our studies showing a persisting anisotropy of the He^+ VDF and introduces a limit for the efficiency of pitch-angle scattering. On the other hand we observe anomalous shapes of the He^+ VDF in the vicinity of stream interaction regions, where the VDF tends to be shifted towards higher speeds. These observations may be explained by a modified cooling behaviour in these regions. Furthermore we observe an enhancement of ions above the injection speed that were likely accelerated in compression regions. Here, we present our observations and discuss the implications on the processes named above.

  19. Cluster/Peace Electrons Velocity Distribution Function: Modeling the Strahl in the Solar Wind

    Science.gov (United States)

    Figueroa-Vinas, Adolfo; Gurgiolo, Chris; Goldstein, Melvyn L.

    2008-01-01

    We present a study of kinetic properties of the strahl electron velocity distribution functions (VDF's) in the solar wind. These are used to investigate the pitch-angle scattering and stability of the population to interactions with electromagnetic (whistler) fluctuations. The study is based on high time resolution data from the Cluster/PEACE electron spectrometer. Our study focuses on the mechanisms that control and regulate the pitch-angle and stability of strahl electrons in the solar wind; mechanisms that are not yet well understood. Various parameters are investigated such as the electron heat-flux and temperature anisotropy. The goal is to check whether the strahl electrons are constrained by some instability (e.g., the whistler instability), or are maintained by other types of processes. The electron heat-flux and temperature anisotropy are determined by fitting the VDF's to a spectral spherical harmonic model from which the moments are derived directly from the model coefficients.

  20. Velocity distribution of carbon and oxygen atoms in front of a tokamak limiter

    International Nuclear Information System (INIS)

    From the Doppler-broadened emission profiles of a CI line (3P2→3P20, λ=909.5 nm) and of an OI line (3P2,1,0→3S10, λ=844.6 nm), the velocity distribution of carbon and oxygen atoms in front of a graphite limiter has been deduced. For the π-component of the CI line, the Zeeman splitting is negligible, but for the π-components of the OI line, the Paschen-Back effect has to be taken into account. The contribution of chemical and physical sputtering to the release of impurities under various experimental conditions has been investigated at the tip of the limiter. For C atoms, chemical sputtering dominates at low boundary temperatures, and physical sputtering at high temperature. For oxygen, chemical sputtering is always indicated to be the more efficient process. (orig.)

  1. Particle Paths of Lagrangian Velocity Distribution Simulating the Spiral Arms of Galaxy M51

    Institute of Scientific and Technical Information of China (English)

    Tzu-Fang Chen; Georgios H. Vatistas; Sui Lin

    2008-01-01

    Galaxies are huge families of stars held together by their own gravities. The system M51 is a spiral galaxy. It possesses billions of stars. The range of the spiral arms extends hundred thousand light years. The present study is in an attempt in using the particle paths of the Lagrangian flow field to simulate the spiral arms of Galaxy M51.The Lagrangian flow field is introduced. The initial locations of fluid particles in the space between two concentric cylinders are first specified. Then a linear velocity distribution of the fluid particles is used with different angle rotations of the particles to obtain the particle paths in the Lagrangian diagram. For simulating the spiral arms of Galaxy M51, the Lagrangian M51 diagram is developed. The particle paths of the Lagrangian M51 diagram agree quite well with the spiral arms of Galaxy M51.

  2. Prediction of Pressure, Temperature, and Velocity Distribution of Two-Phase Flow in Oil Wells

    Energy Technology Data Exchange (ETDEWEB)

    Cazarez-Candia, Octavio [Programa de Yacimientos Naturalmente Fracturados, Instituto Mexicano del Petroleo, Eje Central Lazaro Cardenas No. 152, Col. San Bartolo Atepehuacan, CP 07730, Mexico D.F. (Mexico); Vasquez-Cruz, Mario A. [Gerencia de Reservas de Hidrocarburos, PEMEX, Av. Marina Nacional No. 329, Col. Huasteca, C.P. 11311, Mexico D.F. (Mexico)

    2005-03-15

    In this work, a one-dimensional, time-dependent homogeneous mathematical model is presented, which can be used for determining the pressure, temperature, and velocity distributions of two-phase flow with three components (water-oil and gas) in oil wells. The numerical solution of the mathematical model, which consists of mass, momentum, and energy conservation equations, is based on the finite difference technique in the implicit scheme. The thermodynamic and transport properties of the fluids are estimated by black oil PVT correlations. The contribution of the terms of the conservation equations to the prediction of field data is studied. As a result, it was observed that the convective terms do not affect significantly the results of the present model. However, the terms in the energy equation containing the Joule-Thomson coefficient affect sensitively the prediction of temperature, but not the prediction of pressure. Numerical results are in agreement with field data and theoretical results reported in the literature.

  3. Spectroscopic measurement of ion temperature and ion velocity distributions in the flux-coil generated FRC.

    Science.gov (United States)

    Gupta, D; Bolte, N; Gota, H; Hayashi, R; Kiyashko, V; Marsili, P; Morehouse, M; Primavera, S; Roche, T; Wessel, F

    2010-10-01

    One aim of the flux-coil generated field reversed configuration at Tri Alpha Energy (TAE) is to establish the plasma where the ion rotational energy is greater than the ion thermal energy. To verify this, an optical diagnostic was developed to simultaneously measure the Doppler velocity-shift and line-broadening using a 0.75 m, 1800 groves/mm, spectrometer. The output spectrum is magnified and imaged onto a 16-channel photomultiplier tube (PMT) array. The individual PMT outputs are coupled to high-gain, high-frequency, transimpedance amplifiers, providing fast-time response. The Doppler spectroscopy measurements, along with a survey spectrometer and photodiode-light detector, form a suite of diagnostics that provide insights into the time evolution of the plasma-ion distribution and current when accelerated by an azimuthal-electric field. PMID:21033923

  4. Two-dimensional ion velocity distribution functions in inductively coupled argon plasma

    Energy Technology Data Exchange (ETDEWEB)

    Zimmerman, David C [Optical Sciences Company, Anaheim, CA 92806 (United States); McWilliams, Roger [Department of Physics and Astronomy, University of California at Irvine, Irvine, CA 92697 (United States); Edrich, David A [Scientific Applications and Research Associates Inc., Cypress, CA 90630 (United States)

    2005-08-01

    Two-dimensional ion velocity distribution functions (IVDFs) of argon plasmas have been measured with optical tomography via laser-induced fluorescence (LIF). An inductive radio-frequency (RF) coil created the plasmas, and IVDFs were measured versus RF frequency, gas pressure and location (bulk plasma or presheath of a plate). Typical gas pressure was 0.3-0.4 mTorr, RF power 25 W and magnetic field 130 G. Effective perpendicular ion temperature decreased with increasing RF frequency, and changed little with pressure. Optical tomography reveals features of the presheath IVDF that cannot be deduced from LIF scans parallel and perpendicular to the plate alone. Progress also has been made toward performing optical tomography on a commercial ion beam source (Veeco/Ion Tech 3 cm RF Ion Source, Model no. 201). In particular, it has been discovered that the beam energy fluctuates in a range of about 20 eV over the timescale of a few minutes.

  5. Absorption of electron cyclotron waves by super-thermal electron velocity distribution in Tokamak plasmas

    International Nuclear Information System (INIS)

    We consider a Tokamak plasma in which the distribution of electron velocities in the direction paralletl to the magnetic field has a monotonically decreasing superthermal tail. A fully three-dimensional ray-tracing code is used to calculate the absorption of the extraordinary mode in the nonrelativistic limit. The results indicate that small tails (tail fraction <= 0.5%) can significantly affect wave absorption at low densities. In a high-density plasma where the extraordinary mode cutoff is present, tail electrons can cause substantial absorption. The use of a gyrotron with frequency much less than the central electron cyclotron frequency with an outside launch position is found to be verg effective in the presence of tail electrons. (author)

  6. Three-dimensional distribution of random velocity inhomogeneities at the Nankai trough seismogenic zone

    Science.gov (United States)

    Takahashi, T.; Obana, K.; Yamamoto, Y.; Nakanishi, A.; Kaiho, Y.; Kodaira, S.; Kaneda, Y.

    2012-12-01

    The Nankai trough in southwestern Japan is a convergent margin where the Philippine sea plate is subducted beneath the Eurasian plate. There are major faults segments of huge earthquakes that are called Tokai, Tonankai and Nankai earthquakes. According to the earthquake occurrence history over the past hundreds years, we must expect various rupture patters such as simultaneous or nearly continuous ruptures of plural fault segments. Japan Agency for Marine-Earth Science and Technology (JAMSTEC) conducted seismic surveys at Nankai trough in order to clarify mutual relations between seismic structures and fault segments, as a part of "Research concerning Interaction Between the Tokai, Tonankai and Nankai Earthquakes" funded by Ministry of Education, Culture, Sports, Science and Technology, Japan. This study evaluated the spatial distribution of random velocity inhomogeneities from Hyuga-nada to Kii-channel by using velocity seismograms of small and moderate sized earthquakes. Random velocity inhomogeneities are estimated by the peak delay time analysis of S-wave envelopes (e.g., Takahashi et al. 2009). Peak delay time is defined as the time lag from the S-wave onset to its maximal amplitude arrival. This quantity mainly reflects the accumulated multiple forward scattering effect due to random inhomogeneities, and is quite insensitive to the inelastic attenuation. Peak delay times are measured from the rms envelopes of horizontal components at 4-8Hz, 8-16Hz and 16-32Hz. This study used the velocity seismograms that are recorded by 495 ocean bottom seismographs and 378 onshore seismic stations. Onshore stations are composed of the F-net and Hi-net stations that are maintained by National Research Institute for Earth Science and Disaster Prevention (NIED) of Japan. It is assumed that the random inhomogeneities are represented by the von Karman type PSDF. Preliminary result of inversion analysis shows that spectral gradient of PSDF (i.e., scale dependence of

  7. Exploring the velocity distribution of debris flows: An iteration algorithm based approach for complex cross-sections

    Science.gov (United States)

    Han, Zheng; Chen, Guangqi; Li, Yange; Wang, Wei; Zhang, Hong

    2015-07-01

    The estimation of debris-flow velocity in a cross-section is of primary importance due to its correlation to impact force, run up and superelevation. However, previous methods sometimes neglect the observed asymmetric velocity distribution, and consequently underestimate the debris-flow velocity. This paper presents a new approach for exploring the debris-flow velocity distribution in a cross-section. The presented approach uses an iteration algorithm based on the Riemann integral method to search an approximate solution to the unknown flow surface. The established laws for vertical velocity profile are compared and subsequently integrated to analyze the velocity distribution in the cross-section. The major benefit of the presented approach is that natural channels typically with irregular beds and superelevations can be taken into account, and the resulting approximation by the approach well replicates the direct integral solution. The approach is programmed in MATLAB environment, and the code is open to the public. A well-documented debris-flow event in Sichuan Province, China, is used to demonstrate the presented approach. Results show that the solutions of the flow surface and the mean velocity well reproduce the investigated results. Discussion regarding the model sensitivity and the source of errors concludes the paper.

  8. Localization of Axonal Motor Molecules Machinery in Neurodegenerative Disorders

    Directory of Open Access Journals (Sweden)

    Fulvio Florenzano

    2012-04-01

    Full Text Available Axonal transport and neuronal survival depend critically on active transport and axon integrity both for supplying materials and communication to different domains of the cell body. All these actions are executed through cytoskeleton, transport and regulatory elements that appear to be disrupted in neurodegenerative diseases. Motor-driven transport both supplies and clears distal cellular portions with proteins and organelles. This transport is especially relevant in projection and motor neurons, which have long axons to reach the farthest nerve endings. Thus, any disturbance of axonal transport may have severe consequences for neuronal function and survival. A growing body of literature indicates the presence of alterations to the motor molecules machinery, not only in expression levels and phosphorylation, but also in their subcellular distribution within populations of neurons, which are selectively affected in the course of neurodegenerative diseases. The implications of this altered subcellular localization and how this affects axon survival and neuronal death still remain poorly understood, although several hypotheses have been suggested. Furthermore, cytoskeleton and transport element localization can be selectively disrupted in some disorders suggesting that specific loss of the axonal functionality could be a primary hallmark of the disorder. This can lead to axon degeneration and neuronal death either directly, through the functional absence of essential axonal proteins, or indirectly, through failures in communication among different cellular domains. This review compares the localization of cytoskeleton and transport elements in some neurodegenerative disorders to ask what aspects may be essential for axon survival and neuronal death.

  9. Solar wind proton velocity distributions: comparison of the bi-Maxwellian based 16-moment expansion with observations

    International Nuclear Information System (INIS)

    Satellite measurements indicate that velocity distributions for solar wind protons can take on a great variety of shapes. The distributions can be isotropic, can have isotropic cores and anisotropic tails, can be elongated in the magnetic field direction (B), can have cores elongated perpendicular to B and high-velocity tails parallel to B, and can have two peaks. Past attempts to empirically fit distribution functions for solar wind protons using theoretical distribution functions have met with some success. The theoretical distribution functions considered were based on either a zeroth-order isotropic Maxwellian or a zeroth-order bi-Maxwellian, with heat flow correction terms. The purpose of this paper is to study the possible types of velocity distributions that can be obtained from the bi-Maxwellian based 16-moment expansion of the distribution function, assuming macroscopic parameter values characteristic of the range of solar wind conditions. The 16-moment distribution accounts not only for heat flow effects but for the effects of viscous stress as well. While previous studies also took heat flow into account, the theoretical expansions for f and the definitions of the physical moments adopted in these studies were different from those used in this paper. Our choice of the 16-moment expansion and corresponding moment definitions was motivated by the fact that this is the correct generalization of the widely-used Maxwellian-based 13-moment expansion to the case where the zeroth-order distribution is a bi-Maxwellian. We found that most of the features characteristic of solar wind proton distributions can be reproduced with the 16-moment distribution, including the appearance of secondary peaks. We were also able to show how each of the physically significant velocity moments affects the shape of the distribution function. We conclude that the 16-moment distribution function can be a useful tool in interpreting measured distribution functions. (author)

  10. Asymmetric orbital distribution near mean motion resonance: Application to planets observed by Kepler and radial velocities

    International Nuclear Information System (INIS)

    Many multiple-planet systems have been found by the Kepler transit survey and various radial velocity (RV) surveys. Kepler planets show an asymmetric feature, namely, there are small but significant deficits/excesses of planet pairs with orbital period spacing slightly narrow/wide of the exact resonance, particularly near the first order mean motion resonance (MMR), such as 2:1 and 3:2 MMR. Similarly, if not exactly the same, an asymmetric feature (pileup wide of 2:1 MMR) is also seen in RV planets, but only for massive ones. We analytically and numerically study planets' orbital evolutions near and in the MMR. We find that their orbital period ratios could be asymmetrically distributed around the MMR center regardless of dissipation. In the case of no dissipation, Kepler planets' asymmetric orbital distribution could be partly reproduced for 3:2 MMR but not for 2:1 MMR, implying that dissipation might be more important to the latter. The pileup of massive RV planets just wide of 2:1 MMR is found to be consistent with the scenario that planets formed separately then migrated toward the MMR. The location of the pileup infers a K value of 1-100 on the order of magnitude for massive planets, where K is the damping rate ratio between orbital eccentricity and semimajor axis during planet migration.

  11. Diagnosis of mildly relativistic electron velocity distributions by electron cyclotron emission in the Alcator C tokamak

    International Nuclear Information System (INIS)

    Mildly relativistic electron velocity distributions are diagnosed from measurements of the first few electron cyclotron emission harmonics in the Alcator C tokamak. The approach employs a vertical viewing chord through the center of the tokamak plasma terminating at a compact, high-performance viewing dump. The cyclotron emission spectra obtained in this way are dominated by frequency downshifts due to the relativistic mass increase, which discriminates the electrons by their total energy. In this way a one-to-one correspondence between the energy and the emission frequency is accomplished in the absence of harmonic superpositions. The distribution, described by f/sub p/, the line-averaged phase space density, and Λ, the anisotropy factor, is determined from the ratio of the optically thin harmonics or polarizations. Diagnosis of spectra in the second and the third harmonic range of frequencies obtained during lower hybrid heating, current drive, and low density ohmic discharges are carried out, using different methods depending on the degree of harmonic superposition present in the spectrum and the availability of more than one ratio measurement. Discussions of transient phenomena, the radiation temperature measurement from the optically thick first harmonic, and the measurements compared to the angular hard x-ray diagnostic results illuminate the capabilities of the vertically viewing electron cyclotron emission diagnostic

  12. Asymmetric orbital distribution near mean motion resonance: Application to planets observed by Kepler and radial velocities

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Ji-Wei, E-mail: jwxie@nju.edu.cn, E-mail: jwxie@astro.utoronto.ca [Department of Astronomy and Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education, Nanjing University, Nanjing 210093 (China)

    2014-05-10

    Many multiple-planet systems have been found by the Kepler transit survey and various radial velocity (RV) surveys. Kepler planets show an asymmetric feature, namely, there are small but significant deficits/excesses of planet pairs with orbital period spacing slightly narrow/wide of the exact resonance, particularly near the first order mean motion resonance (MMR), such as 2:1 and 3:2 MMR. Similarly, if not exactly the same, an asymmetric feature (pileup wide of 2:1 MMR) is also seen in RV planets, but only for massive ones. We analytically and numerically study planets' orbital evolutions near and in the MMR. We find that their orbital period ratios could be asymmetrically distributed around the MMR center regardless of dissipation. In the case of no dissipation, Kepler planets' asymmetric orbital distribution could be partly reproduced for 3:2 MMR but not for 2:1 MMR, implying that dissipation might be more important to the latter. The pileup of massive RV planets just wide of 2:1 MMR is found to be consistent with the scenario that planets formed separately then migrated toward the MMR. The location of the pileup infers a K value of 1-100 on the order of magnitude for massive planets, where K is the damping rate ratio between orbital eccentricity and semimajor axis during planet migration.

  13. Sensitivity bias in the mass-radius distribution from transit timing variations and radial velocity measurements

    Science.gov (United States)

    Steffen, Jason H.

    2016-04-01

    Motivated by recent discussions, both in private and in the literature, we use a Monte Carlo simulation of planetary systems to investigate sources of bias in determining the mass-radius distribution of exoplanets for the two primary techniques used to measure planetary masses - radial velocities (RVs) and transit timing variations (TTVs). We assert that mass measurements derived from these two methods are comparably reliable - as the physics underlying their respective signals is well understood. Nevertheless, their sensitivity to planet mass varies with the properties of the planets themselves. We find that for a given planet size, the RV method tends to find planets with higher mass while the sensitivity of TTVs is more uniform. This `sensitivity bias' implies that a complete census of TTV systems is likely to yield a more robust estimate of the mass-radius distribution provided there are not important physical differences between planets near and far from mean-motion resonance. We discuss differences in the sensitivity of the two methods with orbital period and system architecture, which may compound the discrepancies between them (e.g. short-period planets detectable by RVs may be more dense due to atmospheric loss). We advocate for continued mass measurements using both approaches as a means both to measure the masses of more planets and to identify potential differences in planet structure that may result from their dynamical and environmental histories.

  14. Optimization and investigation of the effect of velocity distribution of air curtains on the performance of food refrigerated display cabinets

    Science.gov (United States)

    Wu, XueHong; Chang, ZhiJuan; Ma, QiuYang; Lu, YanLi; Yin, XueMei

    2016-08-01

    This paper focuses on improving the performance of the vertical open refrigerated display cabinets (VORDC) by optimizing the structure of deflector, which is affected by inlet velocity and velocity distribution of air curtains. The results show that the temperature of products located at the front and at the rear reduces as the increases of inlet velocity of air curtains. The increase of the inlet velocity of air curtains can strengthen the disturbance inside the VORDC, and also decrease the temperature of products inside the VORDC; the increase of the outer velocity of air curtain will exacerbate the disturbance outside the VORDC and decrease air curtain's performance. The present study can provide a theoretical foundation for the design of VORDC.

  15. Exploration of probability distribution of velocities of saltating sand particles based on the stochastic particle-bed collisions

    International Nuclear Information System (INIS)

    The wind-blown sand saltating movement is mainly categorized into two mechanical processes, that is, the interaction between the moving sand particles and the wind in the saltation layer, and the collisions of incident particles with sand bed, and the latter produces a lift-off velocity of a sand particle moving into saltation. In this Letter a methodology of phenomenological analysis is presented to get probability density (distribution) function (pdf) of the lift-off velocity of sand particles from sand bed based on the stochastic particle-bed collision. After the sand particles are dealt with by uniform circular disks and a 2D collision between an incident particle and the granular bed is employed, we get the analytical formulas of lift-off velocity of ejected and rebound particles in saltation, which are functions of some random parameters such as angle and magnitude of incident velocity of the impacting particles, impact and contact angles between the collision particles, and creeping velocity of sand particles, etc. By introducing the probability density functions (pdf's) of these parameters in communion with all possible patterns of sand bed and all possible particle-bed collisions, and using the essential arithmetic of multi-dimension random variables' pdf, the pdf's of lift-off velocities are deduced out and expressed by the pdf's of the random parameters in the collisions. The numerical results of the distributions of lift-off velocities display that they agree well with experimental ones

  16. Effects of super-Gaussian electron velocity distributions on the ion feature of Thomson scattering off two-ion plasmas

    International Nuclear Information System (INIS)

    The influence of super-Gaussian velocity distributions on the ion feature of Thomson scattering off two-ion plasmas is studied. The analytical solution to the dispersion equation shows that although both the frequencies of the two (fast and slow) ion-acoustic waves increase with the index of the super-Gaussian, the slow wave is more weakly dependent on the index due to the screening of the light ions. In the case that plasma can sustain two lightly damped ion-acoustic waves, the inferred plasma parameters such as electron temperature and plasma temperature ratio may suffer some errors without consideration of super-Gaussian electron velocity distributions. Since the relative intensity between the resonant peaks of the fast and slow waves is sensitive to the super-Gaussian index, the super-Gaussian velocity distributions may be measurable with Thomson scattering off laser-heated two species ion plasmas

  17. Effective velocity distribution in an atom gravimeter: effect of the convolution with the response of the detection

    CERN Document Server

    Farah, Tristan; Cheng, Bing; Landragin, Arnaud; Merlet, Sébastien; Santos, Franck Pereira Dos

    2014-01-01

    We present here a detailed study of the influence of the transverse motion of the atoms in a free-fall gravimeter. By implementing Raman selection in the horizontal directions at the beginning of the atoms free fall, we characterize the effective velocity distribution, ie the velocity distribution of the detected atom, as a function of the laser cooling and trapping parameters. In particular, we show that the response of the detection induces a pronounced asymetry of this effective velocity distribution that depends not only on the imbalance between molasses beams but also on the initial position of the displaced atomic sample. This convolution with the detection has a strong influence on the averaging of the bias due to Coriolis acceleration. The present study allows a fairly good understanding of results previously published in {\\it Louchet-Chauvet et al., NJP 13, 065025 (2011)}, where the mean phase shift due to Coriolis acceleration was found to have a sign different from expected.

  18. Characteristics of proton velocity distribution functions in the near-lunar wake from Chandrayaan-1/SWIM observations

    CERN Document Server

    Dhanya, M B; Futaana, Yoshifumi; Barabash, Stas; Alok, Abhinaw; Wieser, Martin; Holmström, Mats; Wurz, Peter

    2016-01-01

    Due to the high absorption of solar wind plasma on the lunar dayside, a large scale wake structure is formed downstream of the Moon. However, recent in-situ observations have revealed the presence of protons in the near-lunar wake (100 km to 200 km from the surface). The solar wind, either directly or after interaction with the lunar surface (including magnetic anomalies), is the source of these protons in the near-wake region. Using the entire data from the SWIM sensor of the SARA experiment onboard Chandrayaan-1, we analysed the velocity distribution of the protons observed in the near-lunar wake. The average velocity distribution functions, computed in the solar wind rest frame, were further separated based on the angle between the upstream solar wind velocity and the IMF. Several proton populations were identified from the velocity distribution and their possible entry mechanism were inferred based on the characteristics of the velocity distribution. These entry mechanisms include (i) diffusion of solar w...

  19. Angular and Linear Velocity Estimation for a Re-Entry Vehicle Using Six Distributed Accelerometers: Theory, Simulation and Feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Clark, G

    2003-04-28

    This report describes a feasibility study. We are interested in calculating the angular and linear velocities of a re-entry vehicle using six acceleration signals from a distributed accelerometer inertial measurement unit (DAIMU). Earlier work showed that angular and linear velocity calculation using classic nonlinear ordinary differential equation (ODE) solvers is not practically feasible, due to mathematical and numerical difficulties. This report demonstrates the theoretical feasibility of using model-based nonlinear state estimation techniques to obtain the angular and linear velocities in this problem. Practical numerical and calibration issues require additional work to resolve. We show that the six accelerometers in the DAIMU are not sufficient to provide observability, so additional measurements of the system states are required (e.g. from a Global Positioning System (GPS) unit). Given the constraint that our system cannot use GPS, we propose using the existing on-board 3-axis magnetometer to measure angular velocity. We further show that the six nonlinear ODE's for the vehicle kinematics can be decoupled into three ODE's in the angular velocity and three ODE's in the linear velocity. This allows us to formulate a three-state Gauss-Markov system model for the angular velocities, using the magnetometer signals in the measurement model. This re-formulated model is observable, allowing us to build an Extended Kalman Filter (EKF) for estimating the angular velocities. Given the angular velocity estimates from the EKF, the three ODE's for the linear velocity become algebraic, and the linear velocity can be calculated by numerical integration. Thus, we do not need direct measurements of the linear velocity to provide observability, and the technique is mathematically feasible. Using a simulation example, we show that the estimator adds value over the numerical ODE solver in the presence of measurement noise. Calculating the velocities in the

  20. Unexpected patterns of vegetation distribution response and climate change velocities in cold ecosystems

    Science.gov (United States)

    Macias-Fauria, M.; Johnson, E. A.; Forbes, B. C.; Willis, K. J.

    2013-12-01

    In cold ecosystems such as sub-alpine forests and forest-tundra, vegetation geographical ranges are expected to expand upward/northward in a warmer world. Such moving fronts have been predicted to 1) decrease the remaining alpine area in mountain systems, increasing fragmentation and extinction risk of many alpine taxa, and 2) fundamentally modify the energy budget of newly afforested areas, enhancing further regional warming due to a reduction in albedo. The latter is particularly significant in the forest-tundra, where changes over large regions can have regional-to-global effects on climate. An integral part of the expected range shifts is their velocity. Whereas range shifts across thermal gradients can theoretically be fast in an elevation gradient relative to climate velocity (i.e. rate of climate change) due to the short distances involved, large lags are expected over the flat forest-tundra. Mountain regions have thus been identified as buffer areas where species can track climate change, in opposition to flat terrain where climate velocity is faster. Thus, much shorter time-to-equilibrium are expected for advancing upslope sub-alpine forest than for advancing northern boreal forest. We contribute to this discussion by showing two mechanisms that might largely alter the above predictions in opposite directions: 1) In mountain regions, terrain heterogeneity not only allows for slower climate velocities, but slope processes largely affect the advance of vegetation. Indeed, such mechanisms can potentially reduce the climatic signal in vegetation distribution limits (e.g. treeline), precluding it from migrating to climatically favourable areas - since these areas occur in geologically unfavourable ones. Such seemingly local control to species range shifts was found to reduce the climate-sensitive treeline areas in the sub-alpine forest of the Canadian Rocky Mountains to ~5% at a landscape scale, fundamentally altering the predictions of vegetation response to

  1. A new technique for ultrafast velocity distribution measurements of atomic species by post-ionization laser induced fluorescent (PILIF)

    International Nuclear Information System (INIS)

    A new method for single shot velocity distribution measurement of metallic impurities of relevance for studies involving continuous sources, such as limiter experiments in fusion devices or sputtering experiments, based in the combination of Resonant Enhanced Multiphoton ionization (REMPI) and Laser Induced Fluorescence (LIF) is proposed. High ionization yield and good time resolution are expected according to the numerical simulation of the experiment that has been run for several atomic species. Other possible applications of REMPI to plasma edge physics and to conventional techniques for velocity distribution measurements are briefly addressed. (Author) 8 refs

  2. Angular momentum analysis of rotational transfer of superthermal relative velocity distributions

    Energy Technology Data Exchange (ETDEWEB)

    Whiteley, T.W.J.; McCaffery, A.J. [Sussex Univ., Brighton (United Kingdom). School of Molecular Sciences

    1996-12-02

    An angular momentum (AM) theory is developed to calculate the relative populations of final rotational states after collision between a diatomic molecule and an atom having a narrow, superthermal velocity distribution as produced by, e.g. photolysis of a precursor species. Probability densities are derived from semiclassical expressions for energy and angular momentum assuming the classically impulsive limit with the repulsive wall modelled by a hard ellipsoid. The treatment given is general and therefore applies to molecules in which the centre-of-mass does not coincide with the centre of the potential coordinates. A transfer function for RT is derived and applied to the H + CO system. Analysis of the data allows the anisotropy to be extracted which is in good agreement with an ab initio potential surface. The method described allows one to rapidly assess the contributions from the elliptical core of the potential and from other features of the potential, and would permit more sophisticated representations of the topology to be incorporated. (Author).

  3. Measuring ion velocity distribution functions through high-aspect ratio holes in inductively coupled plasmas

    Science.gov (United States)

    Cunge, G.; Darnon, M.; Dubois, J.; Bezard, P.; Mourey, O.; Petit-Etienne, C.; Vallier, L.; Despiau-Pujo, E.; Sadeghi, N.

    2016-02-01

    Several issues associated with plasma etching of high aspect ratio structures originate from the ions' bombardment of the sidewalls of the feature. The off normal angle incident ions are primarily due to their temperature at the sheath edge and possibly to charging effects. We have measured the ion velocity distribution function (IVDF) at the wafer surface in an industrial inductively coupled plasma reactor by using multigrid retarding field analyzers (RFA) in front of which we place 400 μm thick capillary plates with holes of 25, 50, and 100 μm diameters. The RFA then probes IVDF at the exit of the holes with Aspect Ratios (AR) of 16, 8, and 4, respectively. The results show that the ion flux dramatically drops with the increase in AR. By comparing the measured IVDF with an analytical model, we concluded that the ion temperature is 0.27 eV in our plasma conditions. The charging effects are also observed and are shown to significantly reduce the ion energy at the bottom of the feature but only with a "minor" effect on the ion flux and the shape of the IVDF.

  4. Uptake, distribution, and velocity of organically complexed plutonium in corn (Zea mays)

    International Nuclear Information System (INIS)

    Lysimeter experiments and associated simulations suggested that Pu moved into and through plants that invaded field lysimeters during an 11-year study at the Savannah River Site. However, probable plant uptake and transport mechanisms were not well defined, so more detailed study is needed. Therefore, experiments were performed to examine movement, distribution, and velocity of soluble, complexed Pu in corn. Corn was grown and exposed to Pu using a “long root” system in which the primary root extended through a soil pot and into a hydroponic container. To maintain solubility, Pu was complexed with the bacterial siderophore DFOB (Desferrioxamine B) or the chelating agent DTPA (diethylenetriaminepentaacetic acid). Corn plants were exposed to nutrient solutions containing Pu for periods of 10 min to 10 d. Analysis of root and shoot tissues permitted concentration measurement and calculation of uptake velocity and Pu retardation in corn. Results showed that depending on exposure time, 98.3–95.9% of Pu entering the plant was retained in the roots external to the xylem, and that 1.7–4.1% of Pu entered the shoots (shoot fraction increased with exposure time). Corn Pu uptake was 2–4 times greater as Pu(DFOB) than as Pu2(DTPA)3. Pu(DFOB) solution entered the root xylem and moved 1.74 m h−1 or greater upward, which is more than a million times faster than Pu(III/IV) downward movement through soil during the lysimeter study. The Pu(DFOB) xylem retardation factor was estimated to be 3.7–11, allowing for rapid upward Pu transport and potential environmental release. - Highlights: ► By measuring radioactivity, we recorded the uptake of plutonium (Pu) by corn roots. ► Unlike Pu behavior in soil, Pu complexes moved rapidly through plant tissues. ► Pu accumulated in the root tissue external to the xylem and in the corn leaves. ► The 58 cm travel time from roots to leaves was between 10 and 20 min.

  5. Spatial distribution of random velocity inhomogeneities in the western part of Nankai subduction zone

    Science.gov (United States)

    Takahashi, T.; Obana, K.; Yamamoto, Y.; Nakanishi, A.; Kodaira, S.; Kaneda, Y.

    2011-12-01

    In the Nankai trough, there are three seismogenic zones of megathrust earthquakes (Tokai, Tonankai and Nankai earthquakes). Lithospheric structures in and around these seismogenic zones are important for the studies on mutual interactions and synchronization of their fault ruptures. Recent studies on seismic wave scattering at high frequencies (>1Hz) make it possible to estimate 3D distributions of random inhomogeneities (or scattering coefficient) in the lithosphere, and clarified that random inhomogeneity is one of the important medium properties related to microseismicity and damaged structure near the fault zone [Asano & Hasegawa, 2004; Takahashi et al. 2009]. This study estimates the spatial distribution of the power spectral density function (PSDF) of random inhomogeneities the western part of Nankai subduction zone, and examines the relations with crustal velocity structure and seismic activity. Seismic waveform data used in this study are those recorded at seismic stations of Hi-net & F-net operated by NIED, and 160 ocean bottom seismographs (OBSs) deployed at Hyuga-nada region from Dec. 2008 to Jan. 2009. This OBS observation was conducted by JAMSTEC as a part of "Research concerning Interaction Between the Tokai, Tonankai and Nankai Earthquakes" funded by Ministry of Education, Culture, Sports, Science and Technology, Japan. Spatial distribution of random inhomogeneities is estimated by the inversion analysis of the peak delay time of small earthquakes [Takahashi et al. 2009], where the peak delay time is defined as the time lag from the S-wave onset to its maximal amplitude arrival. We assumed the von Karman type functional form for the PSDF. Peak delay times are measured from root mean squared envelopes at 4-8Hz, 8-16Hz and 16-32Hz. Inversion result can be summarized as follows. Random inhomogeneities beneath the Quaternary volcanoes are characterized by strong inhomogeneities at small spatial scale (~ a few hundreds meter) and weak spectral gradient

  6. Irregular geometries in normal unmyelinated axons: a 3D serial EM analysis.

    Science.gov (United States)

    Greenberg, M M; Leitao, C; Trogadis, J; Stevens, J K

    1990-12-01

    Axons have generally been represented as straight cylinders. It is not at all uncommon for anatomists to take single cross-sections of an axonal bundle, and from the axonal diameter compute expected conduction velocities. This assumes that each cross-section represents a slice through a perfect cylinder. We have examined the three-dimensional geometry of 98 central and peripheral unmyelinated axons, using computer-assisted serial electron microscopy. These reconstructions reveal that virtually all unmyelinated axons have highly irregular axial shapes consisting of periodic varicosities. The varicosities were, without exception, filled with membranous organelles frequently including mitochondria, and have obligatory volumes similar to that described in other neurites. The mitochondria make contact with microtubules, while the other membraneous organelles were frequently found free floating in the cytoplasm. We conclude that unmyelinated axons are fundamentally varicose structures created by the presence of organelles, and that an axon's calibre is dynamic in both space and time. These irregular axonal geometries raise serious doubts about standard two dimensional morphometric analysis and suggest that electrical properties may be more heterogeneous than expected from single section data. These results also suggest that the total number of microtubules contained in an axon, rather than its single section diameter, may prove to be a more accurate predictor of properties such as conduction velocity. Finally, these results offer an explanation for a number of pathological changes that have been described in unmyelinated axons. PMID:2292722

  7. Angular, velocity, rotational, and electronic distributions of vibrationally elastically scattered NO(v = 1) from LiF(100)

    Energy Technology Data Exchange (ETDEWEB)

    Misewich, J.; Zacharias, H.; Loy, M.M.T.

    1985-09-01

    Infrared laser excitation has been utilized to excite part of a molecular beam of NO to a single well-defined quantum state, NO(v = 1, J = 3/2, ..cap omega.. = 1/2), which is scattered from a cleaved LiF(100) surface. Laser spectroscopic detection techniques then allow the determination of rotational and electronic distributions as well as state-specific angular and velocity distributions for scattering from a single initial vibrational-rotational state.

  8. Integral cross section measurements and product recoil velocity distributions of Xe2+ + N2 hyperthermal charge-transfer collisions

    Science.gov (United States)

    Hause, Michael L.; Prince, Benjamin D.; Bemish, Raymond J.

    2016-07-01

    Charge exchange from doubly charged rare gas cations to simple diatomics proceeds with a large cross section and results in populations of many vibrational and electronic product states. The charge exchange between Xe2+ and N2, in particular, is known to create N2 + in both the A and B electronic states. In this work, we present integral charge exchange cross section measurements of the Xe2+ + N2 reaction as well as axial recoil velocity distributions of the Xe+ and N2 + product ions for collision energies between 0.3 and 100 eV in the center-of-mass (COM) frame. Total charge-exchange cross sections decrease from 70 Å2 to about 40 Å2 with increasing collision energy through this range. Analysis of the axial velocity distributions indicates that a Xe2+ - N2 complex exists at low collision energies but is absent by 17.6 eV COM. Analysis of the axial velocity distributions reveals evidence for complexes with lifetimes comparable to the rotational period at low collision energies. The velocity distributions are consistent with quasi-resonant single charge transfer at high collision energies.

  9. Integral cross section measurements and product recoil velocity distributions of Xe(2+) + N2 hyperthermal charge-transfer collisions.

    Science.gov (United States)

    Hause, Michael L; Prince, Benjamin D; Bemish, Raymond J

    2016-07-28

    Charge exchange from doubly charged rare gas cations to simple diatomics proceeds with a large cross section and results in populations of many vibrational and electronic product states. The charge exchange between Xe(2+) and N2, in particular, is known to create N2 (+) in both the A and B electronic states. In this work, we present integral charge exchange cross section measurements of the Xe(2+) + N2 reaction as well as axial recoil velocity distributions of the Xe(+) and N2 (+) product ions for collision energies between 0.3 and 100 eV in the center-of-mass (COM) frame. Total charge-exchange cross sections decrease from 70 Å(2) to about 40 Å(2) with increasing collision energy through this range. Analysis of the axial velocity distributions indicates that a Xe(2+) - N2 complex exists at low collision energies but is absent by 17.6 eV COM. Analysis of the axial velocity distributions reveals evidence for complexes with lifetimes comparable to the rotational period at low collision energies. The velocity distributions are consistent with quasi-resonant single charge transfer at high collision energies. PMID:27475363

  10. Axonal transport of ribonucleoprotein particles (vaults).

    Science.gov (United States)

    Li, J Y; Volknandt, W; Dahlstrom, A; Herrmann, C; Blasi, J; Das, B; Zimmermann, H

    1999-01-01

    RNA was previously shown to be transported into both dendritic and axonal compartments of nerve cells, presumably involving a ribonucleoprotein particle. In order to reveal potential mechanisms of transport we investigated the axonal transport of the major vault protein of the electric ray Torpedo marmorata. This protein is the major protein component of a ribonucleoprotein particle (vault) carrying a non-translatable RNA and has a wide distribution in the animal kingdom. It is highly enriched in the cholinergic electromotor neurons and similar in size to synaptic vesicles. The axonal transport of vaults was investigated by immunofluorescence, using the anti-vault protein antibody as marker, and cytofluorimetric scanning, and was compared to that of the synaptic vesicle membrane protein SV2 and of the beta-subunit of the F1-ATPase as a marker for mitochondria. Following a crush significant axonal accumulation of SV2 proximal to the crush could first be observed after 1 h, that of mitochondria after 3 h and that of vaults after 6 h, although weekly fluorescent traces of accumulations of vault protein were observed in the confocal microscope as early as 3 h. Within the time-period investigated (up to 72 h) the accumulation of all markers increased continuously. Retrograde accumulations also occurred, and the immunofluorescence for the retrograde component, indicating recycling, was weaker than that for the anterograde component, suggesting that more than half of the vaults are degraded within the nerve terminal. High resolution immunofluorescence revealed a granular structure-in accordance with the biochemical characteristics of vaults. Of interest was the observation that the increase of vault immunoreactivity proximal to the crush accelerated with time after crushing, while that of SV2-containing particles appeared to decelerate, indicating that the crush procedure with time may have induced perikaryal alterations in the production and subsequent export to the axon

  11. Brain gangliosides in axon-myelin stability and axon regeneration

    OpenAIRE

    Schnaar, Ronald L.

    2009-01-01

    Gangliosides, sialic acid-bearing glycosphingolipids, are expressed at high abundance and complexity in the brain. Altered ganglioside expression results in neural disorders, including seizures and axon degeneration. Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG). MAG, on the innermost wrap of the myelin sheath, binds to gangliosides GD1a and GT1b on axons. MAG-ganglioside binding ensures optimal axon-myelin cell-ce...

  12. Verification of the network flow and transport/distributed velocity (NWFT/DVM) computer code

    International Nuclear Information System (INIS)

    The Network Flow and Transport/Distributed Velocity Method (NWFT/DVM) computer code was developed primarily to fulfill a need for a computationally efficient ground-water flow and contaminant transport capability for use in risk analyses where, quite frequently, large numbers of calculations are required. It is a semi-analytic, quasi-two-dimensional network code that simulates ground-water flow and the transport of dissolved species (radionuclides) in a saturated porous medium. The development of this code was carried out under a program funded by the US Nuclear Regulatory Commission (NRC) to develop a methodology for assessing the risk from disposal of radioactive wastes in deep geologic formations (FIN: A-1192 and A-1266). In support to the methodology development program, the NRC has funded a separate Maintenance of Computer Programs Project (FIN: A-1166) to ensure that the codes developed under A-1192 or A-1266 remain consistent with current operating systems, are as error-free as possible, and have up-to-date documentations for reference by the NRC staff. Part of this effort would include verification and validation tests to assure that a code correctly performs the operations specified and/or is representing the processes or system for which it is intended. This document contains four verification problems for the NWFT/DVM computer code. Two of these problems are analytical verifications of NWFT/DVM where results are compared to analytical solutions. The other two are code-to-code verifications where results from NWFT/DVM are compared to those of another computer code. In all cases NWFT/DVM showed good agreement with both the analytical solutions and the results from the other code

  13. Transfer of vesicles from Schwann cell to axon: a novel mechanism of communication in the peripheral nervous system

    Directory of Open Access Journals (Sweden)

    María Alejandra eLopez-Verrilli

    2012-06-01

    Full Text Available Schwann cells (SCs are the glial component of the peripheral nervous system, with essential roles during development and maintenance of axons, as well as during regenerative processes after nerve injury. SCs increase conduction velocities by myelinating axons, regulate synaptic activity at presynaptic nerve terminals and are a source of trophic factors to neurons. Thus, development and maintenance of peripheral nerves are crucially dependent on local signalling between SCs and axons. In addition to the classic mechanisms of intercellular signalling, the possibility of communication through secreted vesicles has been poorly explored to date. Interesting recent findings suggest the occurrence of lateral transfer mediated by vesicles from glial cells to axons that could have important roles in axonal growth and axonal regeneration. Here, we review the role of vesicular transfer from SCs to axons and propose the benefits of this means in supporting neuronal and axonal maintenance and regeneration after nerve damage.

  14. DETECTION OF THE VELOCITY SHEAR EFFECT ON THE SPATIAL DISTRIBUTIONS OF THE GALACTIC SATELLITES IN ISOLATED SYSTEMS

    International Nuclear Information System (INIS)

    We report a detection of the effect of the large-scale velocity shear on the spatial distributions of the galactic satellites around the isolated hosts. Identifying the isolated galactic systems, each of which consists of a single host galaxy and its satellites, from the Seventh Data Release of the Sloan Digital Sky Survey and reconstructing linearly the velocity shear field in the local universe, we measure the alignments between the relative positions of the satellites from their isolated hosts and the principal axes of the local velocity shear tensors projected onto the plane of sky. We find a clear signal that the galactic satellites in isolated systems are located preferentially along the directions of the minor principal axes of the large-scale velocity shear field. Those galactic satellites that are spirals, are brighter, are located at distances larger than the projected virial radii of the hosts, and belong to the spiral hosts yield stronger alignment signals, which implies that the alignment strength depends on the formation and accretion epochs of the galactic satellites. It is also shown that the alignment strength is quite insensitive to the cosmic web environment, as well as the size and luminosity of the isolated hosts. Although this result is consistent with the numerical finding of Libeskind et al. based on an N-body experiment, owing to the very low significance of the observed signals, it remains inconclusive whether or not the velocity shear effect on the satellite distribution is truly universal

  15. DETECTION OF THE VELOCITY SHEAR EFFECT ON THE SPATIAL DISTRIBUTIONS OF THE GALACTIC SATELLITES IN ISOLATED SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jounghun [Astronomy Program, Department of Physics and Astronomy, Seoul National University, Seoul 151-747 (Korea, Republic of); Choi, Yun-Young, E-mail: jounghun@astro.snu.ac.kr, E-mail: yy.choi@khu.ac.kr [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of)

    2015-02-01

    We report a detection of the effect of the large-scale velocity shear on the spatial distributions of the galactic satellites around the isolated hosts. Identifying the isolated galactic systems, each of which consists of a single host galaxy and its satellites, from the Seventh Data Release of the Sloan Digital Sky Survey and reconstructing linearly the velocity shear field in the local universe, we measure the alignments between the relative positions of the satellites from their isolated hosts and the principal axes of the local velocity shear tensors projected onto the plane of sky. We find a clear signal that the galactic satellites in isolated systems are located preferentially along the directions of the minor principal axes of the large-scale velocity shear field. Those galactic satellites that are spirals, are brighter, are located at distances larger than the projected virial radii of the hosts, and belong to the spiral hosts yield stronger alignment signals, which implies that the alignment strength depends on the formation and accretion epochs of the galactic satellites. It is also shown that the alignment strength is quite insensitive to the cosmic web environment, as well as the size and luminosity of the isolated hosts. Although this result is consistent with the numerical finding of Libeskind et al. based on an N-body experiment, owing to the very low significance of the observed signals, it remains inconclusive whether or not the velocity shear effect on the satellite distribution is truly universal.

  16. Characterising volcanic activity of Piton de la Fournaise volcano by the spatial distribution of seismic velocity changes

    Science.gov (United States)

    Sens-Schoenfelder, C.; Pomponi, E.

    2013-12-01

    We apply Passive Image Interferometry to investigate the seismic noise recorded from October 2009 until December 2011 by 21 stations of the IPGP/OVPF seismic network installed on Piton de la Fournaise volcano within the UnderVolc project. The analyzed period contains three eruptions in 2009 and January 2010, two eruptions plus one dyke intrusion in late 2010, and a seismic crises in 2011. Seismic noise of vertical and horizontal components is cross-correlated to measure velocity changes as apparent stretching of the coda. For some station pairs the apparent velocity changes exceed 1% and a decorrelation of waveforms is observed at the time of volcanic activity. This distorts monitoring results if changes are measured with respect to a global reference. To overcome this we present a method to estimate changes using multiple references that stabilizes the quality of estimated velocity changes. We observe abrupt changes that occur coincident with volcanic events as well as long term transient signals. Using a simple assumption about the spatial sensitivity of our measurements we can map the spatial distribution of velocity changes for selected periods. Comparing these signals with volcanic activity and GPS derived surface deformation we can identify patterns of the velocity changes that appear characteristic for the type of volcanic activity. We can differentiate intrusive processes associated with inflation and increased seismic activity, periods of relaxation without seismicity and eruptions solely based on the velocity signal. This information can help to assess the processes acting in the volcano.

  17. Differential Axonal Projection of Mitral and Tufted Cells in the Mouse Main Olfactory System

    Directory of Open Access Journals (Sweden)

    Shin Nagayama

    2010-09-01

    Full Text Available In the past decade, much has been elucidated regarding the functional organization of the axonal connection of olfactory sensory neurons to olfactory bulb (OB glomeruli. However, the manner in which projection neurons of the OB process odorant input and send this information to higher brain centers remains unclear. Here, we report long-range, large-scale tracing of the axonal projection patterns of OB neurons using two-photon microscopy. Tracer injection into a single glomerulus demonstrated widely distributed mitral/tufted cell axonal projections on the lateroventral surface of the mouse brain, including the anterior/posterior piriform cortex (PC and olfactory tubercle (OT. We noted two distinct groups of labeled axons: PC-orienting axons and OT-orienting axons. Each group occupied distinct parts of the lateral olfactory tract. PC-orienting axons projected axon collaterals to a wide area of the PC but only a few collaterals to the OT. OT-orienting axons densely projected axon collaterals primarily to the anterolateral OT (alOT. Different colored dye injections into the superficial and deep portions of the OB external plexiform layer revealed that the PC-orienting axon populations originated in presumed mitral cells and the OT-orienting axons in presumed tufted cells. These data suggest that although mitral and tufted cells receive similar odor signals from a shared glomerulus, they process the odor information in different ways and send their output to different higher brain centers via the PC and alOT.

  18. Microfluidic control of axonal guidance

    Science.gov (United States)

    Gu, Ling; Black, Bryan; Ordonez, Simon; Mondal, Argha; Jain, Ankur; Mohanty, Samarendra

    2014-10-01

    The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may directly affect neuronal guidance during early organ development. Here, we report direct evidence of fluid flow influencing axonal migration, producing turning angles of up to 90°. Microfluidic flow simulations indicate that an axon may experience significant bending force due to cross-flow, which may contribute to the observed axonal turning. This method of flow-based guidance was successfully used to fasciculate one advancing axon onto another, showcasing the potential of this technique to be used for the formation of in vitro neuronal circuits.

  19. ON THE COMPETITION BETWEEN RADIAL EXPANSION AND COULOMB COLLISIONS IN SHAPING THE ELECTRON VELOCITY DISTRIBUTION FUNCTION: KINETIC SIMULATIONS

    International Nuclear Information System (INIS)

    We present numerical simulations of the solar wind using a fully kinetic model which takes into account the effects of particle's binary collisions in a quasi-neutral plasma in spherical expansion. Starting from an isotropic Maxwellian velocity distribution function for the electrons, we show that the combined effect of expansion and Coulomb collisions leads to the formation of two populations: a collision-dominated cold and dense population almost isotropic in velocity space and a weakly collisional, tenuous field-aligned and antisunward drifting population generated by mirror force focusing in the radially decreasing magnetic field. The relative weights and drift velocities for the two populations observed in our simulations are in excellent agreement with the relative weights and drift velocities for both core and strahl populations observed in the real solar wind. The radial evolution of the main moments of the electron velocity distribution function is in the range observed in the solar wind. The electron temperature anisotropy with respect to the magnetic field direction is found to be related to the ratio between the collisional time and the solar wind expansion time. Even though collisions are found to shape the electron velocity distributions and regulate the properties of the strahl, it is found that the heat flux is conveniently described by a collisionless model where a fraction of the electron thermal energy is advected at the solar wind speed. This reinforces the currently largely admitted fact that collisions in the solar wind are clearly insufficient to force the electron heat flux obey the classical Spitzer-Härm expression where heat flux and temperature gradient are proportional to each other. The presented results show that the electron dynamics in the solar wind cannot be understood without considering the role of collisions.

  20. The Influence of Volcanic Processes on the Distribution of Seismic Velocity Changes at Piton de la Fournaise Volcano (La Reunion)

    Science.gov (United States)

    Sens-Schönfelder, Christoph; Pomponi, Eraldo

    2014-05-01

    The velocity of seismic waves propagating in the edifice of Piton de la Fournaise volcano (La Reunion) is known to change in response to volcanic eruptions. Here we present a detailed investigation of a the period from end of 2009 until end of 2011 that contains eruptions, non-eruptive intrusions and periods of relaxation and perform a detailed comparison of the associated velocity signals. We use data from by 21 seismograph stations of the IPGP/OVPF seismic network installed on Piton de la Fournaise volcano within the UnderVolc project. Seismic noise of vertical and horizontal components of all possible station pairs is cross-correlated in chunks of 24 hours to obtain daily approximations of Green's functions in order to monitor tiny changes in therein that are related to changes of the elastic properties in the volcano. Velocity changes are measured as apparent stretching of the coda. For some station pairs the apparent velocity changes exceed 1% and a decorrelation of waveforms is observed at the time of volcanic activity. This distorts monitoring results if changes are measured with respect to a global reference. To overcome this we present a method to estimate changes using multiple references that stabilizes the quality of estimated velocity changes. We observe abrupt changes that occur coincident with volcanic events as well as long term transient signals. Using a simple assumption about the spatial sensitivity of our measurements we can map the spatial distribution of velocity changes for selected periods. Comparing these signals with volcanic activity and GPS derived surface displacement we can identify patterns of the velocity changes that appear characteristic for the different types of volcanic activity. We can differentiate intrusive processes associated with inflation and increased seismic activity, periods of relaxation without seismicity and eruptions solely based on the velocity signal. This information can help to assess the processes acting in

  1. Effects of tangential velocity distribution on flow stability in a draft tube

    Science.gov (United States)

    Dou, Huashu; Niu, Lin; Cao, Shuliang

    2014-10-01

    Numerical simulations of the flow in the draft tube of a Francis turbine are carried out in order to elucidate the effects of tangential velocity on flow stability. Influence of the location of the maximum tangential velocity is explored considering the equality of the total energy at the inlet of the draft tube. It is found that the amplitude of the pressure fluctuation decreases when the location of the maximum of the tangential velocity moves from the centre to the wall on the cross section. Thus, the stability of the flow in the draft tube increases with the moving of the location of the maximum tangential velocity. However, the relative hydraulic loss increases and the recovery coefficient of the draft tube decreases slightly.

  2. Exponential tails in the centroid velocity distributions of star-forming regions

    CERN Document Server

    Miesch, M S; Miesch, Mark S; Scalo, John M

    1994-01-01

    Probability density functions (pdfs) of ^{13}CO emission line centroid (line-of-sight, intensity-weighted average) velocities are presented for several densely sampled molecular clouds as quantitative descriptors of their underlying dynamics. Although some are approximately Gaussian in form, most of the pdfs exhibit relatively broader, often nearly exponential, tails, similar to the pdfs of velocity {\\em differences} and {\\em derivatives} (but not the velocity field itself) found in experiments and numerical simulations of incompressible turbulence. The broad pdf tails found in the present work are also similar to those found in decades-old measurements of interstellar velocity pdfs using atomic line centroids, and to the excess wing emission recently found in individual molecular line profiles. Some possible interpretations of the observed deviations are briefly discussed, although none of these account for the nearly exponential tails.

  3. Time-evolution of the ion velocity distribution function in the discharge of a Hall effect thruster

    OpenAIRE

    Mazouffre, S.; Gawron, D.; N. Sadeghi

    2009-01-01

    The temporal characteristics of the Xe$^+$ ion axial Velocity Distribution Function (VDF) were recorded in the course of low-frequency discharge current oscillations ($\\sim$~14 kHz) of the 5 kW-class PPS$\\circledR$X000 Hall thruster. The evolution in time of the ion axial velocity component is monitored by means of a laser induced fluorescence diagnostic tool with a time resolution of 100 ns. As the number of fluorescence photons is very low during such a short time period, a hom-made pulse-c...

  4. Effect of the Temperature of the Moderator on the Velocity Distribution of Neutrons with Numerical Calculations for H as Moderator

    Science.gov (United States)

    Wigner, E. P.; Wilkins, J. E. Jr.

    1944-09-14

    In this paper we set up an integral equation governing the energy distribution of neutrons that are being slowed down uniformly throughout the entire space by a uniformly distributed moderator whose atoms are in motion with a Maxwellian distribution of velocities. The effects of chemical binding and crystal reflection are ignored. When the moderator is hydrogen, the integral equation is reduced to a differential equation and solved by numerical methods. In this manner we obtain a refinement of the dv/v{sup 2} law. (auth)

  5. Study of Current Sheath Velocity and Its Distribution Using Tridimensional Magnetic Probe in Sahand Plasma Focus

    Science.gov (United States)

    A. Mohammadi, M.; Hedyeh, S.

    2015-05-01

    The current sheath velocity in 0.25 Torr gas pressure of Filippov type plasma focus is studied experimentally. By using two tridimensional magnetic probes on top of the anode surface, the current sheath velocity is measured for argon, oxygen and nitrogen. Additionally, the effect of charging voltage on the current sheath velocity is studied in both axial and radial phases. We found that, the maximum current sheath velocities at both radial and axial phases are respectively 4.33 ± 0.28 (cm/μs) and 3.92 ± 0.75 (cm/μs) with argon as the working gas at 17 kV. Also, the minimum values of current sheath velocity are 1.48 ± 0.15 (cm/μs) at the radial phase and 1.14 ± 0.09 (cm/μs) at the axial phase with oxygen at 12 kV. The current sheath velocity at the radial phase is higher than that at the axial phase for all gases and voltages. In this study, variation of the full width half maximum (FWHM) of magnetic probe signals with voltage is investigated for different gases at radial and axial phases.

  6. A probabilistic description of the bed load sediment flux: 3. The particle velocity distribution and the diffusive flux

    Science.gov (United States)

    Furbish, David Jon; Roseberry, John C.; Schmeeckle, Mark W.

    2012-09-01

    Particles transported as bed load within a specified streambed area possess at any instant a distribution of velocities. This distribution figures prominently in describing the rates of transport and dispersal of particles. High-speed imaging of sand particles transported as bed load over a planar bed reveals that the probability density functions of the streamwise and cross-stream particle velocities are exponential-like. For quasi-steady conditions the exponential-like density of streamwise velocities reflects a balance among three fluxes in momentum space: (1) an advection of streamwise momentum whose magnitude and sign vary with the momentum state; (2) a diffusion of momentum from higher to lower values of momentum density; and (3) a drift of momentum from regions in momentum space having high average rates of generation of kinetic energy toward regions having low rates of generation of kinetic energy. The probability density of cross-stream velocities similarly reflects a balance of fluxes of cross-stream momentum. Whereas the average net force acting on particles is zero under steady conditions, the mean, variance and asymmetry of the distribution of forces acting on particles vary with the momentum state of the particles. Numerical simulations of particle motions that are faithful to these statistical properties reproduce key empirical results, namely, the exponential-like velocity distribution and the nonlinear relation between hop distances and travel times. The simulations also illustrate how steady gradients in particle activity, the solid volume of particles in motion per unit streambed area, induce a diffusive flux as described in companion papers.

  7. Can flow velocity distribution at a pore-scale be quantified by a celerity-saturation curve?

    Science.gov (United States)

    Shao, Wei; Su, Ye; Bogaard, Thom; Bakker, Mark; Savenije, Huub

    2015-04-01

    The macroscopic subsurface hydrological behaviour, such as surface water infiltration, volumetric water flow in a hillslope, groundwater pressure propagation, or tracer transport, are intimately related with the variability of microscopic flow velocity in the soil porous medium. The subsurface flow equations, expressed by a continuum approach, conceptualize the uniform flow in a representative elementary volume (REV), in which the volumetric flow velocity and average pore velocity are two common variables of water flow velocity. Even though a combination of the continuity equation with Darcian flow velocity is able to quantify the volumetric flow, such a continuum approach is unable to represent the variability of flow velocity at pore-scale. As result of the homogeneity assumption in the subsurface flow equations, the pore-scale heterogeneity cannot be fully represented. Celerity describes the speed of a perturbation-induced propagation of flow or pressure wave. The physical meaning of celerity differs in saturated and unsaturated condition, and such difference can lead to confusion. Specifically, for saturated flow, the celerity indicates pressure transmission, while, for unsaturated flow, the celerity transmits a disturbance through water flow. If a soil is in an equilibrium state (steady condition), even a 'tiny disturbance' of water actuates both water flow and pressure propagation following the path of minimum resistance. Under a perturbation analysis, the celerity, therefore, represents the maximum pore water velocity among all the water-filled pores that contribute to the water flow. Consequently, the relationship between celerity and effective soil saturation reveals a distribution of pore water velocities. A theoretical study was performed to analyse and quantify the hydraulic behaviour of natural soils with a special emphasis on the difference between pore water flow velocity and pressure propagation. The Mualem-Van Genuchten and Brooks

  8. Mass, velocity, angular and charge-state distributions from the fusion of /sup 32/S and /sup 112/Sn

    Energy Technology Data Exchange (ETDEWEB)

    Bolton, C.; Schier, W.A.; Tsoupas, N.; Enge, H.; Salomaa, M.; Sperduto, A.; Graue, A.

    1978-07-01

    Evaporation residues from the fusion of /sup 32/S and /sup 112/Sn at E/sub /sup 32/S/ = 160 meV were studied using an energy-mass spectrometer. The velocity selector of the energy-mass spectrometer was first utilized to measure summed fusion products as a function of velocity setting and reaction angle. In-flight mass separtion of the fusion products with the energy-mass spectrometer identified masses 141, 140, and 139 from the evaporation of three to five nucleons from the /sup 144/Dy compound nucleus. Absolute cross-section measurements are compared to theoretical predictions of the statistical evaporation model. Velocity, angular and charge state distributions of evaporation residues are also compared to calculated values.

  9. The effect of reported high-velocity small raindrops on inferred drop size distributions and derived power laws

    Directory of Open Access Journals (Sweden)

    H. Leijnse

    2010-07-01

    Full Text Available It has recently been shown that at high rainfall intensities, small raindrops may fall with much larger velocities than would be expected from their diameters. These were argued to be fragments of recently broken-up larger drops. In this paper we quantify the effect of this phenomenon on raindrop size distribution measurements from a Joss-Waldvogel disdrometer, a 2-D Video Distrometer, and a vertically-pointing Doppler radar. Probability distributions of fall velocities have been parameterized, where the parameters are functions of both rainfall intensity and drop size. These parameterizations have been used to correct Joss-Waldvogel disdrometer measurements for this phenomenon. The effect of these corrections on fitted scaled drop size distributions are apparent but not major. Fitted gamma distributions for three different types of rainfall have been used to simulate drop size measurements. The effect of the high-velocity small drops is shown to be minor. Especially for the purpose of remote sensing of rainfall using radar, microwave links, or optical links, the errors caused by using the slightly different retrieval relations will be masked completely by other error sources.

  10. Velocity distribution of the flow field in the cyclonic zone of cyclone-static micro-bubble flotation column

    Institute of Scientific and Technical Information of China (English)

    Deng Xiao-wei; Liu Jiong-tian; Wang Yong-tian; Cao Yi-jun

    2013-01-01

    Laboratory experiments have been conducted to study the flow field in a cyclone static micro-bubble flotation column.The method of Particle Image Velocimetry (PIV) was used.The flow field velocity distribution in both cross section and longitudinal section within cyclonic zone was studied for different circulating volumes.The cross sectional vortex was also analyzed.The results show that in cross section as the circulating volume increases from 0.187 to 0.350 m3/h,the flow velocity ranges from 0 to 0.68 m/s.The flow field is mainly a non-vortex potential flow that forms a free vortex without outside energy input.In the cyclonic region the vortex deviates from the center of the flotation column because a single tangential opening introduces circulating fluid into the column.The tangential component of the velocity plays a defining role in the cross section.In the longitudinal section the velocity ranges from 0 to 0.08 m/s.The flow velocity increases as does the circulating volume.Advantageous mineral separation conditions arise from the combined effects of cyclonic flow in cross and longitudinal section.

  11. The distribution of spectral index of magnetic field and ion velocity in Pi2 frequency band in BBFs: THEMIS statistics

    Science.gov (United States)

    Wu, Q.; Du, A. M.; Volwerk, M.; Wang, G. Q.

    2016-09-01

    A statistical study of the THEMIS FGM and ESA data is performed on turbulence of magnetic field and velocity for 218 selected 12 min intervals in BBFs. The spectral index α in the frequency range of 0.005-0.06 Hz are Gaussian distributions. The peaks indexes of total ion velocity Vi and parallel velocity V‖ are 1.95 and 2.07 nearly the spectral index of intermittent low frequency turbulence with large amplitude. However, most probable α of perpendicular velocity V⊥ is about 1.75. It is a little bigger than 5/3 of Kolmogorov (1941). The peak indexes of total magnetic field BT is 1.70 similar to V⊥. Compression magnetic field B‖ are 1.85 which is smaller than 2 and bigger than 5/3 of Kolmogorov (1941). The most probable spectral index of shear B⊥ is about 1.44 which is close to 3/2 of Kraichnan (1965). Max V⊥ have little effect on the power magnitude of VT and V‖ but is positively correlated to spectral index of V⊥. The spectral power of BT, B‖ and B⊥ increase with max perpendicular velocity but spectral indexes of them are negatively correlated to V⊥. The spectral index and the spectral power of magnetic field over the frequency interval 0.005-0.06 Hz is very different from that over 0.08-1 Hz.

  12. Axon-glia interaction and membrane traffic in myelin formation

    Directory of Open Access Journals (Sweden)

    Robin eWhite

    2014-01-01

    Full Text Available In vertebrate nervous systems myelination of neuronal axons has evolved to increase conduction velocity of electrical impulses with minimal space and energy requirements. Myelin is formed by specialised glial cells which ensheath axons with a lipid-rich insulating membrane. Myelination is a multi-step process initiated by axon-glia recognition triggering glial polarisation followed by targeted myelin membrane expansion and compaction. Thereby, a myelin sheath of complex subdomain structure is established. Continuous communication between neurons and glial cells is essential for myelin maintenance and axonal integrity. A diverse group of diseases, from multiple sclerosis to schizophrenia, have been linked to malfunction of myelinating cells reflecting the physiological importance of the axon-glial unit. This review describes the mechanisms of axonal signal integration by oligodendrocytes emphasising the central role of the Src-family kinase Fyn during CNS myelination. Furthermore, we discuss myelin membrane trafficking with particular focus on endocytic recycling and the control of PLP (proteolipid protein transport by SNARE proteins. Finally, PLP mistrafficking is considered in the context of myelin diseases.

  13. The VLT-FLAMES Tarantula Survey X: Evidence for a bimodal distribution of rotational velocities for the single early B-type stars

    OpenAIRE

    Dufton, P. L.; Langer, N.; Dunstall, P. R.; Evans, C J; Brott, I; Mink, S.E. de; Howarth, I. D.; Kennedy, M; McEvoy, C.; Potter, A. T.; Ramirez-Agudelo, O. H.; Sana, Hugues; Simon-Diaz, S.; Taylor, W.; Vink, J. S.

    2012-01-01

    Aims: Projected rotational velocities (\\vsini) have been estimated for 334 targets in the VLT-FLAMES Tarantula survey that do not manifest significant radial velocity variations and are not supergiants. They have spectral types from approximately O9.5 to B3. The estimates have been analysed to infer the underlying rotational velocity distribution, which is critical for understanding the evolution of massive stars. Methods: Projected rotational velocities were deduced from the Fourier transfor...

  14. Non-Maxwellian electron velocity distribution as a result of electron-attachment collisions in ionized gases

    International Nuclear Information System (INIS)

    The effects of electron-attachment collisions on the velocity distribution of electrons is studied on the basis of Boltzmann kinetic equations governing the energetic balance of electrons (e), atoms of a carrier gas (c), and SF6-molecules (m) capturing electrons. Under the assumption that 1) the densities of the particles fulfill the conditions nsub(e) << nsub(c), nsub(m), nsub(m) << nsub(c), and that 2) only the electron-attachment process is in competition with the elastic collision process between electrons and the atoms of the carrier gas, the time behaviour of the energetic balance of the electrons is investigated. The calculations lead to non-Maxwellian forms of the electron velocity distribution changing the mean electron energy. (author)

  15. Velocity spectra and angular distributions of evaporation residues from sup 32 S + sup 12 C at 145 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Arena, N.; Cavallaro, S.; Femino' , S.; Figuera, P.; Pirrone, S.; Porto, F.; Sambataro, S. (Dipartimento di Fisica, Universita di Catania, Universita di Messina, Istituto Nazionale di Fisica Nucleare, Sezione di Catania and Laboratorio Nazionale del Sud I-95129 Catania (Italy))

    1991-11-01

    Velocity spectra and angular and mass distributions for the evaporation residues of the {sup 32}S+{sup 12}C system at {ital E}{sup 32}S=145 MeV in the angular range 3{degree}{le}{var theta}{sub {ital L}}{le}12{degree} have been measured. In order to separate compound nucleus evaporation residues from other heavy reaction products, a kinematic analysis based on simple statistical assumptions relative to the velocity spectra was performed. The structures in the mass distribution are compared with the LILITA code predictions. The fusion excitation function of the existing results is compared with theoretical models. The total reaction cross section has been extracted by means of the modified sum of differences method.

  16. Measurements of the ion velocity distribution in an ultracold neutral plasma derived from a cold, dense Rydberg gas

    CERN Document Server

    Bergeson, S D

    2016-01-01

    We report measurements of the ion velocity distribution in an ultracold neutral plasma derived from a dense, cold Rydberg gas in a MOT. The Rydberg atoms are excited using a resonant two-step excitation pathway with lasers of 4 ns duration. The plasma forms spontaneously and rapidly. The rms width of the ion velocity distribution is determined by measuring laser-induced fluorescence (LIF) of the ions. The measured excitation efficiency is compared with a Monte-Carlo wavefunction calculation, and significant differences are observed. We discuss the conditions for blockaded Rydberg excitation and the subsequent spatial ordering of Rydberg atom domains. While the blockade interaction is greater than the Rabi frequency in portions of the atomic sample, no evidence for spatial ordering is observed.

  17. Ion velocity distribution functions in argon and helium discharges: detailed comparison of numerical simulation results and experimental data

    CERN Document Server

    Wang, Huihui; Kaganovich, Igor D; Mustafaev, Alexander S

    2016-01-01

    Using Monte Carlo Collisions (MCC) method, we have performed simulations of ion velocity distribution functions (IVDF) taking into account both elastic collisions and charge exchange collisions of ions with atoms in uniform electric fields for argon and helium background gases. The simulation results are verified by comparison with the experiment data of the ion drift velocities and the ion transverse diffusion coefficients in argon and helium. The recently published experimental data for the first seven coefficients of the Legendre polynomial expansion of the ion energy and angular distribution functions are used to validate simulation results for IVDF. Good agreements between measured and simulated IVDFs show that the developed simulation model can be used for accurate calculations of IVDFs.

  18. The Spanwise Distribution of Losses in Prismatic Turbine Cascade with Non-Uniform Inlet Velocity Profile

    Czech Academy of Sciences Publication Activity Database

    Fürst, J.; Luxa, Martin; Šimurda, David

    2014-01-01

    Roč. 21, č. 2 (2014), s. 135-141. ISSN 1802-1484 R&D Projects: GA ČR(CZ) GAP101/10/1329 Institutional support: RVO:61388998 Keywords : prismatic turbine cascade * losses * velocity profile Subject RIV: BK - Fluid Dynamics http://www.engineeringmechanics.cz/obsahy.html?R=21&C=2

  19. EXPERIMENTAL STUDY OF VELOCITY DISTRIBUTIONS IN THE TRANSITION REGION OF PIPES

    Institute of Scientific and Technical Information of China (English)

    LIU Yong-hui; DU Guang-sheng; LIU Li-ping; SHAO Zhu-feng; ZHAI Cheng-yuan

    2011-01-01

    The accuracy of an ultrasonic flowmeter meaurement depends on the profile-linear average velocity.But this velocity in the transition region is not available at the present.In this article,the velocity in the transition region in pipes is studied by experimental methods.The Particle Image Velocimetry ( PIV ) is used to measure the flow field in the transition region in pipes,and the measured results from PIV are in good agreement with the Westerwell's experimental data.Based on the experimental data of PIV,the curves of the profile-linear average velocity in the transition region against the Reynolds number in the range from 2 000 to 20 000 are obtained,and it is shown that the coefficient k is constant when the Reynolds number is in the range of 2 000-2 400 and 6 000-20 000,and the coefficient k is increasing when the Reynolds number is in the range of 2 400-6 000.The results of this article can be used to improve the measurement accuracy of the ultrasonic flowmeters and as a theoretical basis for the research on the transition flow.

  20. Angular distribution of the total cyclotron radiation of a relativistic particle with parallel velocity

    International Nuclear Information System (INIS)

    A closed form formula is given for the mean power radiated per solid angle in a given direction by a relativistic particle in cyclotronic motion with a non zero parallel velocity. The difference between emitted and received mean power for a non closed periodic motion is illustrated in this case

  1. Cutoff effects of electron velocity distribution to the properties of plasma parameters near the plasma-sheath boundary

    International Nuclear Information System (INIS)

    The plasma properties under high thermodynamic non-equilibrium condition, established due to the presence of electrically biased electrode, are investigated. Assumption of electron cut-off velocity distribution function (VDF), as done by Andrews and Varey in their investigations of the sheath region [J. Phys. A 3, 413 (1970)], has been extended here to both plasma and sheath regions. Analytic expressions for the moments of electron VDF, as well as for the electron screening temperature function dependence on the plasma-sheath local potential are derived. In deriving the ion velocity distribution the ''standard'' assumption of strict plasma quasineutrality, or equivalently vanishing of the plasma Debye length, is employed, whereas the ions are assumed to be generated at rest over the plasma region. However, unlike the standard approach of solving the plasma equation, where pure Boltzmann electron density profile is used, here we employ modified Boltzmann's electron density profile, due to cutoff effect of the electron velocity distribution. It is shown that under these conditions the quasineutrality equation solution is characterised by the electric field singularity for any negative value of the electrode bias potential as measured with respect to the plasma potential. The point of singularity i.e., the plasma length and its dependence on the electrode bias and sheath potential is established for the particular case of ionization profile mechanism proportional to the local electron density. Relevant parameters for the kinetic Bohm criterion are explicitly calculated for both ions and electrons, for arbitrary electrode bias.

  2. Angular and velocity distributions of desorbing product carbon dioxide from two reaction sites on platinum(110)(1×2)

    OpenAIRE

    Ohno, Yuichi; Matsushima, Tatsuo; Uetsuka, Hiroshi

    1994-01-01

    The angular and velocity distributions of desorbing product CO2 were studied on a platinum(110)(1×2) surface over a wide range of CO coverages by means of angle-resolved thermal desorption combined with a cross-correlation time-of-flight (TOF) technique. Heating the coadsorption layer of CO and oxygen yields four CO2 formation peaks P1–CO2 (~400 K), P2–CO2 (300 K), P3–CO2 (250 K), and P4–CO2 (170 K)]. The angular distribution of each CO2 produced at high CO coverages consists of three desorpt...

  3. Effect of Weakly Nonthermal Ion Velocity Distribution on Jeans Instability in a Complex Plasma in Presence of Secondary Electrons

    International Nuclear Information System (INIS)

    In this paper we have investigated the effect of weak nonthermality of ion velocity distribution on Jean’s instability in a complex plasma in presence of secondary electrons and negatively charged dust grains. The primary and secondary electron temperatures are assumed equal. Thus plasma under consideration consists of three components: Boltzman distributed electrons, non-thermal ions and negatively charged inertial dust grains. From the linear dispersion relation we have calculated the real frequency and growth rate of the Jean’s mode. Numerically we have found that secondary electron emission destabilizes Jean’s mode when ion nonthermality is weak. (author)

  4. The genetics of axonal transport and axonal transport disorders.

    Directory of Open Access Journals (Sweden)

    Jason E Duncan

    2006-09-01

    Full Text Available Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability. In this review, we focus on insights that have emerged from the genetic analysis of long-distance axonal transport between the cell body and the synaptic terminal. We also discuss recent genetic evidence that supports the hypothesis that disruptions in axonal transport may cause or dramatically contribute to neurodegenerative diseases.

  5. Velocity distribution of free particles in the modified special relativity theory

    OpenAIRE

    Liu, Jian-Miin

    1998-01-01

    Keeping the two fundamental postulates of the special theory of relativity, the principle of relativity and the constancy of the one-way velocity of light in all inertial frames of reference, and assuming two generalized Finslerian structures of gravity-free space and time in the usual inertial coordinate system, we can modify the special theory of relativity. The modified theory is still characterized by the localized Lorentz transformation between any two usual inertial coordinate systems. ...

  6. The Three-Dimensional Velocity Distribution of Wide Gap Taylor-Couette Flow Modelled by CFD

    Directory of Open Access Journals (Sweden)

    David Shina Adebayo

    2016-01-01

    Full Text Available A numerical investigation is conducted for the flow between two concentric cylinders with a wide gap, relevant to bearing chamber applications. This wide gap configuration has received comparatively less attention than narrow gap journal bearing type geometries. The flow in the gap between an inner rotating cylinder and an outer stationary cylinder has been modelled as an incompressible flow using an implicit finite volume RANS scheme with the realisable k-ε model. The model flow is above the critical Taylor number at which axisymmetric counterrotating Taylor vortices are formed. The tangential velocity profiles at all axial locations are different from typical journal bearing applications, where the velocity profiles are quasilinear. The predicted results led to two significant findings of impact in rotating machinery operations. Firstly, the axial variation of the tangential velocity gradient induces an axially varying shear stress, resulting in local bands of enhanced work input to the working fluid. This is likely to cause unwanted heat transfer on the surface in high torque turbomachinery applications. Secondly, the radial inflow at the axial end-wall boundaries is likely to promote the transport of debris to the junction between the end-collar and the rotating cylinder, causing the build-up of fouling in the seal.

  7. Highly transverse velocity distribution of convoy electrons emitted by highly charged ions

    Science.gov (United States)

    Seliger, M.; Tőkési, K.; Reinhold, C. O.; Burgdörfer, J.

    2003-05-01

    We present a theoretical study of convoy electron emission resulting from highly charged ion (HCI) transport through carbon foils. Employing a classical transport theory we analyze the angular and energy distribution formed by multiple scattering of electrons in the solid. We find that the convoy electron distribution becomes highly transverse at intermediate foil thicknesses representing an oblate spheroidal distribution due to the stepwise excitation of the HCI. The calculated convoy electron spectra are found to be in good agreement with recent measurements.

  8. Distribution of protons from a plasma focus in velocity-time space by time-resolved Thomson spectroscopy

    International Nuclear Information System (INIS)

    A time-resolving Thomson spectrometer has been used to analyze the protons produced by a plasma focus. The authors use a compact Thomson spectrometer and modulate the electric field--a time-resolving Thomson spectrometer. The resulting spectrograms have patterns of particle tracks that are oscillatory about the θ-b axis (i.e., the line of zero electric deflection). The zero-crossing, intersections of the trace with the θ-b axis, provide information about the relative arrival time of particles at the spectrometer (chi=iota). As with the conventional Thomson spectrometer, the magnetic deflection provides the particle velocity. This velocity is plotted versus particle arrival time. This plot is then transformed to velocity versus particle production time at the plasma focus (chi=0). The authors have adjusted the experimental parameters to improve time resolution from about one nanosecond to sub-nanosecond. This allows a coarse plot of particle number distribution in velocity-time space. Their experimental set-up is designed to produce a 123 MHz modulation in the electric field using a transmitter at that frequency, instead of the 27 MHz used previously. Also a shortened drift region provides increased particle intensity on the spectrograms. The particle detector is CR-39 plastic, which is etched to reveal particle tracks that are visible under an optical microscope. The resulting time-resolved Thomson spectrograms have more zero-crossings than before, thus providing improved time resolution

  9. Examination of appropriate formulations for velocity and pressure calculation methods at interfacial region on collocated physical variables' distribution

    International Nuclear Information System (INIS)

    Authors are developing a high-precision simulation method for gas-liquid two-phase flows on an unstructured grid as a part of numerical studies on gas entrainment phenomena in a sodium-cooled fast reactor. In this study, unphysical behaviors of velocity or pressure distributions near gas-liquid interface induced by inappropriate formulations of momentum advection or velocity-pressure coupling are discussed and appropriate formulations are derived considering proper balance condition of physical quantities. By using these new algorithms, the unphysical behaviors disappeared and numerical simulations could be conduced stably. As a validation of developed simulation method, one air bubble rising in static water was simulated under several conditions dominated by Morton and Eotvos numbers. As a result, simulated bubble shapes well coincided with experimentally observed shapes in each condition. In addition, similar bubble shapes and velocity distributions with results of simulations on the structured grid were obtained on the unstructured grid. These results show that our simulation method can achieve high-precision two-phase flow simulations on both the structured and the unstructured grids. (author)

  10. Impact of velocity space distribution on hybrid kinetic-magnetohydrodynamic simulation of the (1,1) mode

    International Nuclear Information System (INIS)

    Numeric studies of the impact of the velocity space distribution on the stabilization of (1,1) internal kink mode and excitation of the fishbone mode are performed with a hybrid kinetic-magnetohydrodynamic model. These simulations demonstrate an extension of the physics capabilities of NIMROD[C. R. Sovinec et al., J. Comput. Phys. 195, 355 (2004)], a three-dimensional extended magnetohydrodynamic (MHD) code, to include the kinetic effects of an energetic minority ion species. Kinetic effects are captured by a modification of the usual MHD momentum equation to include a pressure tensor calculated from the δf particle-in-cell method [S. E. Parker and W. W. Lee, Phys. Fluids B 5, 77 (1993)]. The particles are advanced in the self-consistent NIMROD fields. We outline the implementation and present simulation results of energetic minority ion stabilization of the (1,1) internal kink mode and excitation of the fishbone mode. A benchmark of the linear growth rate and real frequency is shown to agree well with another code. The impact of the details of the velocity space distribution is examined; particularly extending the velocity space cutoff of the simulation particles. Modestly increasing the cutoff strongly impacts the (1,1) mode. Numeric experiments are performed to study the impact of passing versus trapped particles. Observations of these numeric experiments suggest that assumptions of energetic particle effects should be re-examined.

  11. Risk methodology for geologic disposal of radioactive waste: The distributed velocity method of solving the convective-dispersion equation

    International Nuclear Information System (INIS)

    A new method is proposed for treating convective-dispersive transport. The motivation for developing this technique arises from the demands of performing a risk assessment for a nuclear waste repository. These demands include computational efficiency over a relatively large range of Peclet numbers and the ability to handle chains of decaying radionuclides with rather extreme contrasts in both solution velocities and half lives. To the extent it has been tested to date, the Distributed Velocity Method (DVM) appears to satisfy these demands. Included in this paper are the mathematical theory, numerical implementation, an error analysis employing statistical sampling and regression analysis techniques, and comparisons of DVM with other methods for convective-dispersive transport. (author)

  12. Improving the modelling of redshift-space distortions: I. A bivariate Gaussian description for the galaxy pairwise velocity distributions

    CERN Document Server

    Bianchi, Davide; Guzzo, Luigi

    2014-01-01

    As a step towards a more accurate modelling of redshift-space distortions in galaxy surveys, we develop a general description of the probability distribution function of galaxy pairwise velocities within the framework of the so-called streaming model. For a given galaxy separation $\\vec{r}$, such function can be described as a superposition of virtually infinite local distributions. We characterize these in terms of their moments and then consider the specific case in which they are Gaussian functions, each with its own mean $\\mu$ and dispersion $\\sigma$. Based on physical considerations, we make the further crucial assumption that these two parameters are in turn distributed according to a bivariate Gaussian, with its own mean and covariance matrix. Tests using numerical simulations explicitly show that with this compact description one can correctly model redshift-space distorsions on all scales, fully capturing the overall linear and nonlinear dynamics of the galaxy flow at different separations. In partic...

  13. Electron velocity distribution function in a plasma with temperature gradient and in the presence of suprathermal electrons: application to incoherent-scatter plasma lines

    Directory of Open Access Journals (Sweden)

    P. Guio

    Full Text Available The plasma dispersion function and the reduced velocity distribution function are calculated numerically for any arbitrary velocity distribution function with cylindrical symmetry along the magnetic field. The electron velocity distribution is separated into two distributions representing the distribution of the ambient electrons and the suprathermal electrons. The velocity distribution function of the ambient electrons is modelled by a near-Maxwellian distribution function in presence of a temperature gradient and a potential electric field. The velocity distribution function of the suprathermal electrons is derived from a numerical model of the angular energy flux spectrum obtained by solving the transport equation of electrons. The numerical method used to calculate the plasma dispersion function and the reduced velocity distribution is described. The numerical code is used with simulated data to evaluate the Doppler frequency asymmetry between the up- and downshifted plasma lines of the incoherent-scatter plasma lines at different wave vectors. It is shown that the observed Doppler asymmetry is more dependent on deviation from the Maxwellian through the thermal part for high-frequency radars, while for low-frequency radars the Doppler asymmetry depends more on the presence of a suprathermal population. It is also seen that the full evaluation of the plasma dispersion function gives larger Doppler asymmetry than the heat flow approximation for Langmuir waves with phase velocity about three to six times the mean thermal velocity. For such waves the moment expansion of the dispersion function is not fully valid and the full calculation of the dispersion function is needed.

    Key words. Non-Maxwellian electron velocity distribution · Incoherent scatter plasma lines · EISCAT · Dielectric response function

  14. Axonal tubulin and axonal microtubules: biochemical evidence for cold stability

    OpenAIRE

    1984-01-01

    Nerve extracts containing tubulin labeled by axonal transport were analyzed by electrophoresis and differential extraction. We found that a substantial fraction of the tubulin in the axons of the retinal ganglion cell of guinea pigs is not solubilized by conventional methods for preparation of microtubules from whole brain. In two-dimensional polyacrylamide gel electrophoresis this cold-insoluble tubulin was biochemically distinct from tubulin obtained from whole brain microtubules prepared b...

  15. QSO Host Galaxy Luminosity and [OIII] Line Width as a Surrogate for Stellar Velocity Distribution

    CERN Document Server

    Bonning, E W; Salviander, S; McLure, R J

    2005-01-01

    Supermassive black holes in galactic nuclei show a close relationship between the black hole mass, luminosity, and stellar velocity dispersion (sigma_*) of the host galaxy bulge. Probing these relationships at high redshift may shed light on the link between the formation of the galactic bulge and central black hole, but direct measurements of stellar velocity dispersion at high redshift are difficult. We show that [OIII] line widths provide a useful surrogate for sigma_* by comparing sigma_[OIII] with the value of sigma_* predicted by the Faber-Jackson relation for QSOs with measured host galaxy luminosity. Over a wide range of AGN luminosity, sigma_[OIII] tracks sigma_*, albeit with considerable scatter. [OIII] line widths are narrower by ~0.1 dex in radio-loud QSOs than in radio-quiet QSOs of similar host luminosity. In low redshift QSOs, the ratio of star formation rate to black hole growth rate is much smaller than the typical ratio of bulge mass to black hole mass.

  16. Starspot distributions on fully convective M dwarfs: implications for radial velocity planet searches

    CERN Document Server

    Barnes, J R; Jones, H R A; Pavlenko, Ya V; Jenkins, J S; Haswell, C A; Lohr, M E

    2015-01-01

    Since M4.5 - M9 dwarfs exhibit equatorial rotation velocities of order 10 km/s on average, radial velocity surveys targeting this stellar population will likely need to find methods to effectively remove starspot jitter. We present the first high resolution Doppler images of the M4.5 dwarf, GJ 791.2A, and the M9 dwarf, LP 944-20. The time series spectra of both objects reveal numerous line profile distortions over the rotation period of each star which we interpret as starspots. The transient distortions are modelled with spot/photosphere contrast ratios that correspond to model atmosphere temperature differences of Tphot-Tspot = 200 and 300 K. GJ 791.2A is a fully convective star with vsini = 35.1 km/s. Although we find more starspot structure at high latitudes, we reconstruct spots at a range of phases and latitudes with a mean spot filling of ~3%. LP 944-20 is one of the brightest known late-M dwarfs, with spectral type M9V and vsini = 30.8 km/s. Its spectral time series exhibits two dominant transient lin...

  17. Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain.

    Science.gov (United States)

    Larsen, Camilla; Shy, Diana; Spindler, Shana R; Fung, Siaumin; Pereanu, Wayne; Younossi-Hartenstein, Amelia; Hartenstein, Volker

    2009-11-15

    The Drosophila central brain is composed of approximately 100 paired lineages, with most lineages comprising 100-150 neurons. Most lineages have a number of important characteristics in common. Typically, neurons of a lineage stay together as a coherent cluster and project their axons into a coherent bundle visible from late embryo to adult. Neurons born during the embryonic period form the primary axon tracts (PATs) that follow stereotyped pathways in the neuropile. Apoptotic cell death removes an average of 30-40% of primary neurons around the time of hatching. Secondary neurons generated during the larval period form secondary axon tracts (SATs) that typically fasciculate with their corresponding primary axon tract. SATs develop into the long fascicles that interconnect the different compartments of the adult brain. Structurally, we distinguish between three types of lineages: PD lineages, characterized by distinct, spatially separate proximal and distal arborizations; C lineages with arborizations distributed continuously along the entire length of their tract; D lineages that lack proximal arborizations. Arborizations of many lineages, in particular those of the PD type, are restricted to distinct neuropile compartments. We propose that compartments are "scaffolded" by individual lineages, or small groups thereof. Thereby, the relatively small number of primary neurons of each primary lineage set up the compartment map in the late embryo. Compartments grow during the larval period simply by an increase in arbor volume of primary neurons. Arbors of secondary neurons form within or adjacent to the larval compartments, resulting in smaller compartment subdivisions and additional, adult specific compartments. PMID:19538956

  18. Distribution Versus Correlation Induced Anomalous Transport in Quenched Random Velocity Fields

    OpenAIRE

    Dentz, Marco; Bolster, Diogo

    2010-01-01

    We study mechanisms of anomalous transport in quenched random media. Broad disorder point distributions and strong disorder correlations cause anomalous transport and can lead to the same anomalous scaling laws for the mean and variance of the particle displacements. The respective mechanisms, however, are fundamentally different. This difference is reflected in the spatial particle densities and first passage time distributions, which provide an indicator to identify the origins of anomalous...

  19. Electron momentum distribution, velocity space instability, and angular momentum in relativistic large aspect ratio diodes

    Energy Technology Data Exchange (ETDEWEB)

    Hazak, G.; Zarmi, Y.; Zinamon, Z.

    1981-06-01

    The detailed structure of electron momentum distribution in relativistic diodes is studied. It is proven that in most of the diode region the momentum distribution is isotropic in fluid rest frame, with azimuthal temperature which, in general, is much larger than the cathode temperature. A diode model based on these conclusions is presented. The model allows for a continuum of electron trajectories at each point. In various limits the results are reduced to well-known cold fluid model results.

  20. Secondary Craters and the Size-Velocity Distribution of Ejected Fragments around Lunar Craters Measured Using LROC Images

    Science.gov (United States)

    Singer, K. N.; Jolliff, B. L.; McKinnon, W. B.

    2013-12-01

    Title: Secondary Craters and the Size-Velocity Distribution of Ejected Fragments around Lunar Craters Measured Using LROC Images Authors: Kelsi N. Singer1, Bradley L. Jolliff1, and William B. McKinnon1 Affiliations: 1. Earth and Planetary Sciences, Washington University in St Louis, St. Louis, MO, United States. We report results from analyzing the size-velocity distribution (SVD) of secondary crater forming fragments from the 93 km diameter Copernicus impact. We measured the diameters of secondary craters and their distances from Copernicus using LROC Wide Angle Camera (WAC) and Narrow Angle Camera (NAC) image data. We then estimated the velocity and size of the ejecta fragment that formed each secondary crater from the range equation for a ballistic trajectory on a sphere and Schmidt-Holsapple scaling relations. Size scaling was carried out in the gravity regime for both non-porous and porous target material properties. We focus on the largest ejecta fragments (dfmax) at a given ejection velocity (υej) and fit the upper envelope of the SVD using quantile regression to an equation of the form dfmax = A*υej ^- β. The velocity exponent, β, describes how quickly fragment sizes fall off with increasing ejection velocity during crater excavation. For Copernicus, we measured 5800 secondary craters, at distances of up to 700 km (15 crater radii), corresponding to an ejecta fragment velocity of approximately 950 m/s. This mapping only includes secondary craters that are part of a radial chain or cluster. The two largest craters in chains near Copernicus that are likely to be secondaries are 6.4 and 5.2 km in diameter. We obtained a velocity exponent, β, of 2.2 × 0.1 for a non-porous surface. This result is similar to Vickery's [1987, GRL 14] determination of β = 1.9 × 0.2 for Copernicus using Lunar Orbiter IV data. The availability of WAC 100 m/pix global mosaics with illumination geometry optimized for morphology allows us to update and extend the work of Vickery

  1. Synaptic Democracy and Vesicular Transport in Axons

    Science.gov (United States)

    Bressloff, Paul C.; Levien, Ethan

    2015-04-01

    Synaptic democracy concerns the general problem of how regions of an axon or dendrite far from the cell body (soma) of a neuron can play an effective role in neuronal function. For example, stimulated synapses far from the soma are unlikely to influence the firing of a neuron unless some sort of active dendritic processing occurs. Analogously, the motor-driven transport of newly synthesized proteins from the soma to presynaptic targets along the axon tends to favor the delivery of resources to proximal synapses. Both of these phenomena reflect fundamental limitations of transport processes based on a localized source. In this Letter, we show that a more democratic distribution of proteins along an axon can be achieved by making the transport process less efficient. This involves two components: bidirectional or "stop-and-go" motor transport (which can be modeled in terms of advection-diffusion), and reversible interactions between motor-cargo complexes and synaptic targets. Both of these features have recently been observed experimentally. Our model suggests that, just as in human societies, there needs to be a balance between "efficiency" and "equality".

  2. Velocity Distribution of Slurry in Horizontal Pipe When Solid Particles Sliding

    Institute of Scientific and Technical Information of China (English)

    ZhangShilin; XuZhenliang; Shaolongtan

    2004-01-01

    Based on the laws of momentum conservation and impulse in accelerating process, the distribution on speed of ununiform slurry flow in a horizontal pipe was studied. According to the momentum change of solid particles and conveying liquid of slurry flow during accelerating, and some effect factors, the relationship between the speed of solid particles and the speed of conveying liquid was obtained.When dealing with the friction between sliding solid particles and pipe, it is pivotal to reasonably distribute component of friction to each solid particle. The friction coefficient between solid particles was obtained by forces analysis and theoretic calculation, and can be used to calculate the friction force on every solid particle. The effect of friction on speed of ever), solid particle was investigated through the impulse law. The result is more accurate than that by using uniform friction on solid particles. It is completely new method to use above theory to get solid particles speed distribution, conveying liquid speed distribution and slurry speed distribution.

  3. Neurofilament Polymer Transport in Axons

    OpenAIRE

    Yan, Yanping; Brown, Anthony

    2005-01-01

    Neurofilament proteins are known to be transported along axons by slow axonal transport, but the form in which they move is controversial. In previous studies on cultured rat sympathetic neurons, we found that green fluorescent protein-tagged neurofilament proteins move predominantly in the form of filamentous structures, and we proposed that these structures are single neurofilament polymers. In the present study, we have tested this hypothesis by using a rapid perfusion technique to capture...

  4. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.

    Directory of Open Access Journals (Sweden)

    Yang Xia

    Full Text Available GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood. By recording from the cut end (bleb of the main axon trunk of layer -5 pyramidal neurons in prefrontal cortical slices, we found that currents evoked by GABA iontophoresis could be blocked by picrotoxin, indicating the expression of GABAA receptors in axons. Stationary noise analysis revealed that single-channel properties of axonal GABAA receptors were similar to those of somatic receptors. Perforated patch recording with gramicidin revealed that the reversal potential of the GABA response was more negative than the resting membrane potential at the axon trunk, suggesting that GABA may hyperpolarize the axonal membrane potential. Further experiments demonstrated that the activation of axonal GABAA receptors regulated the amplitude and duration of action potentials (APs and decreased the AP-induced Ca2+ transients at the axon. Together, our results indicate that the waveform of axonal APs and the downstream Ca2+ signals are modulated by axonal GABAA receptors.

  5. Local translation and directional steering in axons

    OpenAIRE

    Lin, Andrew C; Holt, Christine E.

    2007-01-01

    The assembly of functional neural circuits in the developing brain requires neurons to extend axons to the correct targets. This in turn requires the navigating tips of axons to respond appropriately to guidance cues present along the axonal pathway, despite being cellular ‘outposts' far from the soma. Work over the past few years has demonstrated a critical role for local translation within the axon in this process in vitro, making axon guidance another process that requires spatially locali...

  6. Near-field angular distributions of high velocity ions for low-power hall thrusters

    OpenAIRE

    Sullivan, Regina M.; Yost, Allison; Johnson, Lee K.

    2009-01-01

    Experimental angular distributions of high-energy primary ions in the near-field region of a small Hall thruster between 50-200 mm downstream of the thruster exit plane at a range of centerline angles have been determined using a highly-collimated, energy-selective diagnostic probe. The measurements reveal a wide angular distribution of ions exiting the thruster channel and the formation of a strong, axially-directed jet of ions along the thruster centerline. Comparisons are made to other exp...

  7. Design of a molecular beam surface scattering apparatus for velocity and angular distribution measurements

    Energy Technology Data Exchange (ETDEWEB)

    Ceyer, S.T.; Siekhaus, W.J.; Somorjai, G.A.

    1981-09-01

    A molecular beam surface scattering apparatus designed for the study of corrosion and catalytic surface reactions is described. The apparatus incorporates two molecular or atomic beams aimed at a surface characterized by low energy electron diffraction (LEED) and Auger electron spectroscopy (AES), a rotatable, differentially pumped quadrupole mass spectrometer, and a versatile manipulator. Angular distributions and energy distributions as a function of angle and independent of the surface residence time can be measured. Typical data for the oxidation of deuterium to D/sub 2/O on a Pt(111) crystal surface are presented.

  8. DESIGN OF A MOLECULAR BEAM SURFACE SCATTERING APPARATUS FOR VELOCITY AND ANGULAR DISTRIBUTION MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Ceyer, S. T.; Siekhaus, W. J.; Somorjai, G. A.

    1980-11-01

    A molecular beam surface scattering apparatus designed for the study of corrosion and catalyticsurfacereactions is described. The apparatus incorporates two molecular or atomic beams aimed at a surface characterized by low energy electron diffraction (LEED) and Auger electron spectroscopy (AES), a rotatable, differentially pumped quadrupole mass spectrometer, and a versatile manipulator. Angular distributions and energy distributions as a funcion of angle and independent of the surface residence time can be measured. Typical data for the oxidation of deuterium to D{sub 2}O on a Pt(lll) crystal surface are presented.

  9. THE POSTERIOR DISTRIBUTION OF sin(i) VALUES FOR EXOPLANETS WITH MT sin(i) DETERMINED FROM RADIAL VELOCITY DATA

    International Nuclear Information System (INIS)

    Radial velocity (RV) observations of an exoplanet system giving a value of MT sin(i) condition (i.e., give information about) not only the planet's true mass MT but also the value of sin(i) for that system (where i is the orbital inclination angle). Thus, the value of sin(i) for a system with any particular observed value of MT sin(i) cannot be assumed to be drawn randomly from a distribution corresponding to an isotropic i distribution, i.e., the presumptive prior distribution. Rather, the posterior distribution from which it is drawn depends on the intrinsic distribution of MT for the exoplanet population being studied. We give a simple Bayesian derivation of this relationship and apply it to several 'toy models' for the intrinsic distribution of MT , on which we have significant information from available RV data in some mass ranges but little or none in others. The results show that the effect can be an important one. For example, even for simple power-law distributions of MT , the median value of sin(i) in an observed RV sample can vary between 0.860 and 0.023 (as compared to the 0.866 value for an isotropic i distribution) for indices of the power law in the range between -2 and +1, respectively. Over the same range of indices, the 95% confidence interval on MT varies from 1.0001-2.405 (α = -2) to 1.13-94.34 (α = +2) times larger than MT sin(i) due to sin(i) uncertainty alone. More complex, but still simple and plausible, distributions of MT yield more complicated and somewhat unintuitive posterior sin(i) distributions. In particular, if the MT distribution contains any characteristic mass scale Mc , the posterior sin(i) distribution will depend on the ratio of MT sin(i) to Mc , often in a non-trivial way. Our qualitative conclusion is that RV studies of exoplanets, both individual objects and statistical samples, should regard the sin(i) factor as more than a 'numerical constant of order unity' with simple and well-understood statistical properties. We

  10. Regeneration of motor axons in the rat sciatic nerve studied by labeling with axonally transported radioactive proteins

    International Nuclear Information System (INIS)

    Labeling regenerating axons with axonally transported radioactive proteins provides information about the location of the entire range of axons from the fastest growing ones to those which are trapped in the scar. This technique has been used to study the regeneration of motor axons in the rat sciatic nerve after a crush lesion. From 2 to 14 days after the crush the lumbar spinal cord was exposed by laminectomy and multiple injections of [3H]proline were made stereotactically in the ventral horn. Twenty-four hours later the nerves were removed and the distribution of radioactivity along the nerve was measured by liquid scintillation counting. There was a peak of radioactivity in the regenerating axons distal to the crush due to an accumulation of label in the tips of these axons. After a delay of 3.2 +- 0.2 (S.E.) days, this peak advanced down the nerve at a rate of 3.0 +- 0.1 (S.E.) mm/day. The leading edge of this peak, which marks the location of the endings of the most rapidly growing labeled fibers, moved down the nerve at a rate of 4.4 +- 0.2 mm/day after a delay of 2.1 +- 0.2 days; this is the same time course as that of the most rapidly regenerating sensory axons in the rat sciatic nerve, measured by the pinch test. Another peak of radioactivity at the crush site, presumed to represent the ends of unregenerated axons or misdirected sprouts, declined rapidly during the first week, and more slowly thereafter. (Auth.)

  11. Reactive scattering of halogen molecules. [Angular and velocity distributions, stabilities 6. 8 to 17. 7 kcal/mole, FORTRAN

    Energy Technology Data Exchange (ETDEWEB)

    Valentini, J.J.

    1976-11-01

    A study of the endoergic, bimolecular reactions of F/sub 2/ with I/sub 2/, ICl, and HI in a crossed molecular beam experiment is described. The trihalogens IIF, ClIF, and HIF were directly observed as the products of these reactions. At high collision energies a second reactive channel producing IF becomes important. Product angular and velocity distributions show that this IF does not result from a four-center exchange reaction. Measured threshold energies for the formation of IIF, ClIF, and HIF yield lower bounds to the stabilities of these molecules, with respect to the separated atoms, of 69, 81, and 96 kcal/mole, respectively. Analysis of product center-of-mass angular distributions indicates that a slightly nonlinear approach is most effective in bringing about reaction to form the stable triatomic radical. Also described is a crossed molecular beam study of the Cl + Br/sub 2/ ..-->.. BrCl + Br reaction at collision energies from 6.8 to 17.7 kcal/mole. The results indicate that this reaction has the characteristics of an exoergic reaction on an attractive potential energy surface with early energy release. Reagent translational energy is very efficiently channeled into product internal energy. At high collision energy the reaction appears to approach the spectator stripping limit. Finally, a series of computer programs which can be used to carry out the requisite data analysis for crossed molecular beam reactive scattering experiments are described. These programs recover the reactive scattering center-of-mass flux distribution from the measured angular and velocity distributions of the products.

  12. Study of SBS 1202+583. Features of the Radial Velocity Distribution Over the Field

    Science.gov (United States)

    Hakopian, S. A.

    2014-09-01

    This article is a continuation of our study of the galaxy SBS 1202+583 (VV270ab) by using panoramic spectroscopy data obtained in our observations with multipupil spectrographs - the MPFS at the 6-m telescope of the SAO of the Russian Academy of Sciences and the `'VAGR" at the 2.6-m telescope of the BAO in Armenia. An analysis of the radial velocity field in the Hα emission line of this object, previously characterized as a complex consisting of more than nine HII regions [1], indicates the two main substructures of them. The closest substructure associated with the HII region SBS1202+583C1 (from the component VV270b) is disintegrating under the influence of a distant substructure associated with SBS1202+583NE4 (from the component VV270a) which is the most massive and most powerful Hα emission source. The perturbation field, owing to its gravitational effect, stimulates a directed motion of most of the HII regions as they rotate simultaneously.

  13. Distribution and velocity of inertial particles in a turbulent channel flow

    Science.gov (United States)

    Coletti, Filippo; Fong, Kee Onn; Nemes, Andras; Sloan, Nicholas

    2015-11-01

    The segregation of inertial particles in specific regions of turbulent fluid flows is a well known phenomenon, but experimental observations of its three-dimensional nature are lacking. Here we are concerned with the transport of small inertial particles in wall-bounded turbulence. In particular we consider a fully developed vertical channel flow. The working fluid is air laden with size-selected glass particles. The volume and mass loading are kept low and the particle diameter is smaller than the viscous length scale, so that the turbulence is unaffected by the dispersed phase. Tomographic particle image velocimetry is used to reconstruct the position and velocity of the inertial particles. In particular, the tendency of the particles to concentrate intermittently (turbulence clustering) and to drift towards the wall (turbophoresis) are quantitatively characterized by the instantaneous and mean concentration fields, respectively. The findings are discussed in relation to the results of previous studies which have used one-way coupled direct numerical simulations, and on which the current understanding of this class of flows is based.

  14. Nonlinear Landau damping and formation of Bernstein-Greene-Kruskal structures for plasmas with q-nonextensive velocity distributions

    Science.gov (United States)

    Raghunathan, M.; Ganesh, R.

    2013-03-01

    In the past, long-time evolution of an initial perturbation in collisionless Maxwellian plasma (q = 1) has been simulated numerically. The controversy over the nonlinear fate of such electrostatic perturbations was resolved by Manfredi [Phys. Rev. Lett. 79, 2815-2818 (1997)] using long-time simulations up to t = 1600 ωp - 1 . The oscillations were found to continue indefinitely leading to Bernstein-Greene-Kruskal (BGK)-like phase-space vortices (from here on referred as "BGK structures"). Using a newly developed, high resolution 1D Vlasov-Poisson solver based on piecewise-parabolic method (PPM) advection scheme, we investigate the nonlinear Landau damping in 1D plasma described by toy q-distributions for long times, up to t = 3000 ωp - 1 . We show that BGK structures are found only for a certain range of q-values around q = 1. Beyond this window, for the generic parameters, no BGK structures were observed. We observe that for values of q 1 where distribution has a sharp fall in velocity, the formation of BGK structures is rendered difficult due to high wave number damping imposed by the steep velocity profile, which had not been previously reported. Wherever relevant, we compare our results with past work.

  15. Displaced logarithmic profile of the velocity distribution in the boundary layer of a turbulent flow over an unbounded flat surface

    Science.gov (United States)

    Talpos, Simona; Apostol, Marian

    2015-12-01

    It is shown that the Reynolds equations for a turbulent flow over an unbounded flat surface in the presence of a constant pressure-gradient lead to a displaced logarithmic profile of the velocity distribution; the displaced logarithmic profile is obtained by assuming a constant production rate of turbulence energy. The displacement height measured on the (vertical) axis perpendicular to the surface is either positive or negative. For a positive displacement height the boundary layer exhibits an inversion, while for a negative displacement height the boundary layer is a direct one. In an inversion boundary layer the logarithmic velocity profile is disrupted into two distinct branches separated by a logarithmic singularity. The viscosity transforms this logarithmic singularity into a sharp edge, governed by a generalized Reynolds number. The associated temperature distribution is calculated, and the results are discussed in relation to meteorological boundary-layer jets and stratified layers. The effects of gravitation and atmospheric thermal or fluid-mixture concentration gradients ("external forcings") are also considered; it is shown that such circumstances may lead to various modifications of the boundary layers. A brief presentation of a similar situation is described for a circular pipe.

  16. Rapidly changing distribution of velocity and suspended materials under the drifting Arctic sea ice

    Science.gov (United States)

    Ha, Ho Kyung; Im, Jungho; Kim, Yong Hoon; Yae Son, Eun; Lee, Sanggyun

    2015-04-01

    In two summer seasons of 2011 and 2014, the short-term (1-4 days) ice-camp study has been conducted on the drifting Arctic sea ice. In particular, in 2014, the international collaboration with the Marginal Ice Zone program (sponsored by Office of Naval Research) has been integrated. The mooring package comprises the acoustic Doppler velocity profiler, holographic imaging camera, and conductivity-temperature-depth profiler, which are used to understand the dynamic behavior of sea ice and spatial-temporal variation of mixing layer (ML) and suspended particulate matters under the sea ice. Mooring data clearly shows the mixing and entrainment pattern in the upper ML in the marginal ice zone. When ice floes drift toward the pack ice, the upward entrainment from the seasonal pycnocline to sea ice-water boundary was induced by shear across ML and seasonal pycnocline. The entrainment speed was in the range of 0.25-2 m/hr, which matches well with thickening and thinning rate of ML during the near-inertial period (~12 hr). When ice floes drift toward the open ocean, the turbulent wakes at the advancing edge of ice were combined with the entrainment caused by near-inertial motion, which results in a complex mixing pattern of both upward and downward fluxes in the ML. Also, the acoustic backscatter observed by the acoustic Doppler current profiler and beam attenuation from transmissometer revealed the increased concentration of suspended particulate materials in the ML, which can be direct evidence visualizing the mixing pattern. Results suggest that the mixing and entrainment found in our study sustain particulate matters in suspension within the upper ML for a few months.

  17. Molecular beam studies of unimolecular reactions: Cl, F + C/sub 2/H/sub 3/Br. [Angular and velocity distributions, mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Buss, R.J.; Coggiola, M.J.; Lee, Y.T.

    1978-12-01

    Several methods currently used to study unimolecular decomposition in molecular beams are discussed. Experimental product angular and velocity distributions obtained for the reaction of F, Cl with C/sub 2/H/sub 3/Br are presented. The mechanism by which conservation of angular momemtum can cause coupling of the product angular and velocity distributions in dissociation of long-lived complexes is introduced. 14 references.

  18. Molecular beam scattering investigation of the oxidation of CO on Rh(111). II. Angular and velocity distributions of the CO/sub 2/ product

    Energy Technology Data Exchange (ETDEWEB)

    Brown, L.S.; Sibener, S.J.

    1989-03-01

    Molecular beam and time of flight methods have been used to examine the angular distributions and velocity distributions of the CO/sub 2/ product molecules formed in the catalytic oxidation of CO on a Rh(111) single crystal in the surface temperature range 700--1000 K. The angular distribution was sharply peaked about the surface normal, and cannot be described by a simple cos/sup n/ theta expression. No temperature dependence was observed in the angular distribution over the range of temperatures studied here. Observed velocity distributions were clearly non-Maxwellian and had average translational energies in excess of those expected at the surface temperatures. Furthermore, the average velocity depended strongly on the desorption angle. Molecules desorbing along the surface normal had an average translational energy of approx.8 kcal/mol. The average energy decreased with increasing angle, reaching a value of approx.4 kcal/mol at an angle of 60/sup 0/. All of the observed velocity distributions were narrower than Maxwellian distributions with the same average energies. Product velocity distributions did not appear to vary with surface temperature. The observed excess energies are believed to arise from the crossing of the activation barrier to reaction, with a fraction of the reaction energy being carried away from the surface by the product molecules.

  19. Ejecta velocity distribution of impact craters formed on quartz sand: Effect of projectile density on crater scaling law

    Science.gov (United States)

    Tsujido, Sayaka; Arakawa, Masahiko; Suzuki, Ayako I.; Yasui, Minami

    2015-12-01

    In order to clarify the effects of projectile density on ejecta velocity distributions for a granular target, impact cratering experiments on a quartz sand target were conducted by using eight types of projectiles with different densities ranging from 11 g cm-3 to 1.1 g cm-3, which were launched at about 200 m s-1 from a vertical gas gun at Kobe University. The scaling law of crater size, the ejection angle of ejecta grains, and the angle of the ejecta curtain were also investigated. The ejecta velocity distribution obtained from each projectile was well described by the π-scaling theory of v0/√{gR} =k2(x0/R)-1/μ, where v0, g, R and x0 are the ejection velocity, gravitational acceleration, crater radius and ejection position, respectively, and k2 and μ are constants mostly depending on target material properties (Housen, K.R., Holsapple, K.A. [2011]. Icarus 211, 856-875). The value of k2 was found to be almost constant at 0.7 for all projectiles except for the nylon projectile, while μ increased with the projectile density, from 0.43 for the low-density projectile to 0.6-0.7 for the high-density projectile. On the other hand, the π-scaling theory for crater size gave a μ value of 0.57, which was close to the average of the μ values obtained from ejecta velocity distributions. The ejection angle, θ, of each grain decreased slightly with distance, from higher than 45° near the impact point to 30-40° at 0.6 R. The ejecta curtain angle is controlled by the two elementary processes of ejecta velocity distribution and ejection angle; it gradually increased from 52° to 63° with the increase of the projectile density. The comparison of our experimental results with the theoretical model of the crater excavation flow known as the Z-model revealed that the relationship between μ and θ obtained by our experiments could not be described by the Z-model (Maxwell, D.E. [1977]. In: Roddy, D.J., Pepin, R.O., Merrill, R.B. (Eds.), Impact and Explosion Cratering

  20. The VLT-FLAMES Tarantula Survey X: Evidence for a bimodal distribution of rotational velocities for the single early B-type stars

    CERN Document Server

    Dufton, P L; Dunstall, P R; Evans, C J; Brott, I; de Mink, S E; Howarth, I D; Kennedy, M; McEvoy, C; Potter, A T; Ramírez-Agudelo, O H; Sana, H; Simón-Díaz, S; Taylor, W; Vink, J S

    2012-01-01

    Aims: Projected rotational velocities (\\vsini) have been estimated for 334 targets in the VLT-FLAMES Tarantula survey that do not manifest significant radial velocity variations and are not supergiants. They have spectral types from approximately O9.5 to B3. The estimates have been analysed to infer the underlying rotational velocity distribution, which is critical for understanding the evolution of massive stars. Methods: Projected rotational velocities were deduced from the Fourier transforms of spectral lines, with upper limits also being obtained from profile fitting. For the narrower lined stars, metal and non-diffuse helium lines were adopted, and for the broader lined stars, both non-diffuse and diffuse helium lines; the estimates obtained using the different sets of lines are in good agreement. The uncertainty in the mean estimates is typically 4% for most targets. The iterative deconvolution procedure of Lucy has been used to deduce the probability density distribution of the rotational velocities. R...

  1. Evaluation of the indoor temperature field using a given air velocity distribution

    Energy Technology Data Exchange (ETDEWEB)

    Ghiaus, C.M. [Technical Univ. of Civil Engineering, Building Services Faculty, Bucharest (Romania); Ghiaus, A.G. [Patras Univ., Fluid Mechanics Lab., Patras (Greece)

    1999-07-01

    A new method for compensating the space discretization error introduced when the fixed flow field is considered for the dynamic models of temperature distribution is presented. It is proved that the method generally used in literature is a particular solution of the proposed one. Moreover, it results in a continuous-time mode, for which the integrating method becomes a free choice and a state-space representation is possible. The numerical model was experimentally validated, the comparison, both in the time and in the frequency domains, between simulation and measured results showing good agreement. The presented dynamic model increases the calculation speed and it can be analysed with the tools developed in control theory. (Author)

  2. Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Burke, M. G.; Fonck, R. J.; Bongard, M. W.; Schlossberg, D. J.; Winz, G. R. [Department of Engineering Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)

    2012-10-15

    A passive ion temperature polychromator has been deployed on Pegasus to study power balance and non-thermal ion distributions that arise during point source helicity injection. Spectra are recorded from a 1 m F/8.6 Czerny-Turner polychromator whose output is recorded by an intensified high-speed camera. The use of high orders allows for a dispersion of 0.02 A/mm in 4th order and a bandpass of 0.14 A ({approx}13 km/s) at 3131 A in 4th order with 100 {mu}m entrance slit. The instrument temperature of the spectrometer is 15 eV. Light from the output of an image intensifier in the spectrometer focal plane is coupled to a high-speed CMOS camera. The system can accommodate up to 20 spatial points recorded at 0.5 ms time resolution. During helicity injection, stochastic magnetic fields keep T{sub e} low ({approx}100 eV) and thus low ionization impurities penetrate to the core. Under these conditions, high core ion temperatures are measured (T{sub i} Almost-Equal-To 1.2 keV, T{sub e} Almost-Equal-To 0.1 keV) using spectral lines from carbon III, nitrogen III, and boron IV.

  3. Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment

    International Nuclear Information System (INIS)

    A passive ion temperature polychromator has been deployed on Pegasus to study power balance and non-thermal ion distributions that arise during point source helicity injection. Spectra are recorded from a 1 m F/8.6 Czerny-Turner polychromator whose output is recorded by an intensified high-speed camera. The use of high orders allows for a dispersion of 0.02 Å/mm in 4th order and a bandpass of 0.14 Å (∼13 km/s) at 3131 Å in 4th order with 100 μm entrance slit. The instrument temperature of the spectrometer is 15 eV. Light from the output of an image intensifier in the spectrometer focal plane is coupled to a high-speed CMOS camera. The system can accommodate up to 20 spatial points recorded at 0.5 ms time resolution. During helicity injection, stochastic magnetic fields keep Te low (∼100 eV) and thus low ionization impurities penetrate to the core. Under these conditions, high core ion temperatures are measured (Ti≈ 1.2 keV, Te≈ 0.1 keV) using spectral lines from carbon III, nitrogen III, and boron IV.

  4. Measurements of the Diameter and Velocity Distributions of Atomized Tablet-Coating Solutions for Pharmaceutical Applications

    Science.gov (United States)

    Osterday, Kathryn; Aliseda, Alberto; Lasheras, Juan

    2009-11-01

    The atomization of colloidal suspensions is of particular interest to the manufacturing of tablets and pills used as drug delivery systems by the pharmaceutical industry. At various stages in the manufacturing process, the tablets are coated with a spray of droplets produced by co-axial atomizers. The mechanisms of droplet size and spray formation in these types of atomizers are dominated by Kelvin-Helmholtz and Raleigh-Taylor instabilities for both low[1] and high[2] Ohnesorge numbers. We present detailed phase Doppler measurements of the Sauter Mean Diameter of the droplets produced by co-axial spray atomizers using water-based colloidal suspensions with solid concentrations ranging from fifteen to twenty percent and acetone-based colloidal suspensions with solid concentrations ranging from five to ten percent. Our results compare favorably with predictions by Aliseda's model. This suggests that the final size distribution is mainly determined by the instabilities caused by the sudden acceleration of the liquid interface. [1]Varga, C. M., et al. (2003) J. Fluid Mech. 497:405-434 [2]Aliseda, A. et al. (2008). J. Int. J. Multiphase Flow, 34(2), 161-175.

  5. Kinetic transverse dispersion relation for relativistic magnetized electron-positron plasmas with Maxwell-Jüttner velocity distribution functions

    International Nuclear Information System (INIS)

    We use a kinetic treatment to study the linear transverse dispersion relation for a magnetized isotropic relativistic electron-positron plasma with finite relativistic temperature. The explicit linear dispersion relation for electromagnetic waves propagating along a constant background magnetic field is presented, including an analytical continuation to the whole complex frequency plane for the case of Maxwell-Jüttner velocity distribution functions. This dispersion relation is studied numerically for various temperatures. For left-handed solutions, the system presents two branches, the electromagnetic ordinary mode and the Alfvén mode. In the low frequency regime, the Alfvén branch has two dispersive zones, the normal zone (where ∂ω/∂k > 0) and an anomalous zone (where ∂ω/∂k < 0). We find that in the anomalous zone of the Alfvén branch, the electromagnetic waves are damped, and there is a maximum wave number for which the Alfvén branch is suppressed. We also study the dependence of the Alfvén velocity and effective plasma frequency with the temperature. We complemented the analytical and numerical approaches with relativistic full particle simulations, which consistently agree with the analytical results

  6. Kinetic transverse dispersion relation for relativistic magnetized electron-positron plasmas with Maxwell-Jüttner velocity distribution functions

    Energy Technology Data Exchange (ETDEWEB)

    López, Rodrigo A. [Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Concepción, Concepción (Chile); Moya, Pablo S. [NASA Goddard Space Flight Center, Heliophysics Science Division, Geospace Physics Laboratory, Mail Code 673, Greenbelt, Maryland 20771 (United States); Department of Physics, Catholic University of America, Washington DC, DC 20064 (United States); Muñoz, Víctor [Departamento de Física, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago (Chile); Viñas, Adolfo F. [NASA Goddard Space Flight Center, Heliophysics Science Division, Geospace Physics Laboratory, Mail Code 673, Greenbelt, Maryland 20771 (United States); Valdivia, J. Alejandro [Departamento de Física, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago (Chile); Centro para el Desarrollo de la Nanociencia y la Nanotecnología, CEDENNA, Santiago (Chile)

    2014-09-15

    We use a kinetic treatment to study the linear transverse dispersion relation for a magnetized isotropic relativistic electron-positron plasma with finite relativistic temperature. The explicit linear dispersion relation for electromagnetic waves propagating along a constant background magnetic field is presented, including an analytical continuation to the whole complex frequency plane for the case of Maxwell-Jüttner velocity distribution functions. This dispersion relation is studied numerically for various temperatures. For left-handed solutions, the system presents two branches, the electromagnetic ordinary mode and the Alfvén mode. In the low frequency regime, the Alfvén branch has two dispersive zones, the normal zone (where ∂ω/∂k > 0) and an anomalous zone (where ∂ω/∂k < 0). We find that in the anomalous zone of the Alfvén branch, the electromagnetic waves are damped, and there is a maximum wave number for which the Alfvén branch is suppressed. We also study the dependence of the Alfvén velocity and effective plasma frequency with the temperature. We complemented the analytical and numerical approaches with relativistic full particle simulations, which consistently agree with the analytical results.

  7. 3D velocity distribution functions of heavy ions and kinetic properties of fast solar wind O6+ at 1 AU

    International Nuclear Information System (INIS)

    The kinetic properties of the solar wind are a result of complex interactions in the solar corona and interplanetary space. So far, observations of Velocity Distribution Functions (VDFs) of solar wind heavy ions have been solely 1D. They are known to exhibit non-thermal features, but because they are 1D projections of the 3D velocity phase space it is difficult to interpret them properly. We have modeled heavy-ion VDFs based on 3D observations of protons and alpha particles from Helios. In the model, the magnetic field vector plays a crucial role by defining the symmetry axis of the VDFs. A thermal anisotropy T parallel /T perpendicularto ≠1 and a beam drifting along the magnetic field vector at a relative speed of approximately the Alfven speed are included. The modeled VDFs are analysed using a virtual detector and then compared with data from the Solar Wind Ion Composition Spectrometer (SWICS) on the Advanced Composition Explorer (ACE). Our observations give evidence for the existence of heavy-ion beams. The projection of these beams can explain observed differential streaming. Especially the rare periods of negative differential streaming correspond to periods in which the magnetic field lines are strongly bend no longer pointing towards Earth but towards the Sun. We present in-situ measurements and derived kinetic properties of fast solar wind O6+ at 1 AU.

  8. Time-evolution of the ion velocity distribution function in the discharge of a Hall effect thruster

    CERN Document Server

    Mazouffre, S; Sadeghi, N

    2009-01-01

    The temporal characteristics of the Xe$^+$ ion axial Velocity Distribution Function (VDF) were recorded in the course of low-frequency discharge current oscillations ($\\sim$~14 kHz) of the 5 kW-class PPS$\\circledR$X000 Hall thruster. The evolution in time of the ion axial velocity component is monitored by means of a laser induced fluorescence diagnostic tool with a time resolution of 100 ns. As the number of fluorescence photons is very low during such a short time period, a hom-made pulse-counting lock-in system was used to perform real-time discrimination between background photons and fluorescence photons. The evolution in time of the ion VDF was observed at three locations along the thruster channel axis after a fast shut down of the thruster power. The anode discharge current is switched off at 2 kHz during 5 $\\mu$s without any synchronization with the current oscillation cycle. This approach allows to examine the temporal behavior of the ion VDF during decay and ignition of the discharge as well as dur...

  9. NIHAO project II: Halo shape, phase-space density and velocity distribution of dark matter in galaxy formation simulations

    CERN Document Server

    Butsky, Iryna; Dutton, Aaron A; Wang, Liang; Stinson, Greg S; Penzo, Camilla; Kang, Xi; Keller, Ben W; Wadsley, James

    2015-01-01

    We show the effect of galaxy formation on the dark matter (DM) distribution across a wide range of halo masses. We focus on how baryon physics changes the dark matter halo shape, the so called "pseudo phase-space density distribution" and the velocity distribution within the virial radius, Rvir and in the solar neighborhood. This study is based on the NIHAO galaxy formation simulations, a large suite of cosmological zoom-in simulations. The galaxies reproduce key properties of observed galaxies, and hence offer unique insight into how baryons change the dark matter morphology and kinematics. When compared to dark matter only simulations, the NIHAO haloes have similar shapes at Rvir, but are substantially rounder inside ~0.1 Rvir. In DM-only simulations the inner halo has a minor-to-major axis ratio of c/a~0.5. In hydro simulations c/a increases with halo mass and integrated star formation efficiency, reaching ~0.8 at the Milky Way mass, reconciling a long-standing conflict between observations and DM only sim...

  10. 4-Velocity distribution function using Maxwell-Boltzmann's original approach and a new form of the relativistic equation of state

    CERN Document Server

    Basu, Prasad

    2011-01-01

    Following the original approach of Maxwell-Boltzmann(MB), we derive a 4-velocity distribution function for the relativistic ideal gas. This distribution function perfectly reduces to original MB distribution in the non-relativistic limit. We express the relativistic equation of state(EOS), $\\rho-\\rho_0=(\\gamma-1)^{-1}p$,\\ in the two equations: $\\rho=\\rho_0 f(\\lambda)$,\\ and $p=\\rho_0 g(\\lambda)$, where $\\lambda$\\ is a parameter related to the kinetic energy, hence the temperature, of the gas. In the both extreme limits, they give correct EOS:\\ $\\rho=3p$\\ in the ultra-relativistic, and\\ $\\rho-\\rho_0=3/2p$ in the non-relativistic regime. Using these equations the adiabatic index $\\gamma$ (=$\\frac{c_p}{c_v}$) and the sound speed $a_s$ are calculated as a function of $\\lambda$. They also satisfy the inequalities: $4/3 \\le \\gamma \\le 5/3$ and $a_s \\le \\frac{1}{\\sqrt{3}}$ perfectly.

  11. Study of microinstabilities due to an anisotropic velocity distribution function of the particles of a homogeneous plasma

    International Nuclear Information System (INIS)

    A study is made of instabilities in a plasma with an ion velocity distribution function of the form: foi = 1 / (2*π*αpei*αpai) * λ(νpe - αpei) * e-(vpa2/αpai2). The plasma is assumed to have finite dimensions limited by infinitely conductive boundary surfaces. A theoretical and numerical analysis of marginal stability locates the regions of stability as a function of several parameters; i.e. plasma length, ion anisotropy (τ) and electron temperature (Te). A limiting plasma length is found, below which the plasma is stable regardless of its density. For the parameters of the injection experiment M.M.I.I. at Fontenay-aux-roses it is found that the type of instabilities studied here should not occur. (author)

  12. Ultra-low kinetic energy photoelectron angular distribution measurements in He and Ne using a Velocity Map Imaging spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Juarez, A M; Hoyos-Campo, L M [Institute de Ciencias Fisicas, Universidad Nacional Autonoma de Mexico, Cuernavaca, Mor. 62210 (Mexico); Redt, E; Hoenert, M; Aguilar, A [Lawrence Berkeley National Laboratory, Berkeley CA-94720 (United States); Rolles, D [Max Planck Advanced Study Group, CFEL, D-22761 Hamburg (Germany); Berrah, N, E-mail: aaguilar@lbl.go [Department of Physics, Western Michigan University, Kalamazoo MI-49008 (United States)

    2009-11-01

    We present photoelectron angular distributions (PADs) in Helium and Neon for electrons with excess energies between 5 and 100 meV. These ultra-low kinetic energy PAD measurements were obtained with a modified Velocity Map Imaging spectrometer (VMI) and VUV light from the Advanced Light Source (ALS) synchrotron radiation source. The efficiency and reliability of the spectrometer at this ultra-low kinetic energy range has been tested by determining the variation with energy of the asymmetry, {beta}, parameter of photoelectrons from the s-shell direct ionization in Helium. For Neon, we determined the energy dependent asymmetry parameters across the 's' and 'd' autoionizing resonances between the P{sub 3/2} and P{sub 1/2} ionic states. Furthermore, we measured the asymmetry parameter for photoelectrons produced from the n = 2 to n = 6 satellite states of He. These measurements were performed at values of excess kinetic energy previously unexplored.

  13. Ultra-low kinetic energy photoelectron angular distribution measurements in He and Ne using a Velocity Map Imaging spectrometer

    International Nuclear Information System (INIS)

    We present photoelectron angular distributions (PADs) in Helium and Neon for electrons with excess energies between 5 and 100 meV. These ultra-low kinetic energy PAD measurements were obtained with a modified Velocity Map Imaging spectrometer (VMI) and VUV light from the Advanced Light Source (ALS) synchrotron radiation source. The efficiency and reliability of the spectrometer at this ultra-low kinetic energy range has been tested by determining the variation with energy of the asymmetry, β, parameter of photoelectrons from the s-shell direct ionization in Helium. For Neon, we determined the energy dependent asymmetry parameters across the 's' and 'd' autoionizing resonances between the P3/2 and P1/2 ionic states. Furthermore, we measured the asymmetry parameter for photoelectrons produced from the n = 2 to n = 6 satellite states of He. These measurements were performed at values of excess kinetic energy previously unexplored.

  14. Sensitivity analysis of heated wall temperature and velocity distribution in CFD simulations of the upward flow of supercritical water

    International Nuclear Information System (INIS)

    The main objective of this work was to investigate sensitivities of the heated wall temperature and radial velocity distribution predictions on selected model parameters, in water flow under supercritical conditions. The study was focused on cases in which deterioration of heat transfer occurs. Numerical simulations of the turbulent, upward flow in a circular tube were performed using the commercial CFD code ANSYS CFX 12.1. Implementation of water properties was according to IAPWS IF97. The model sensitivities were examined on the mesh discretization, boundary conditions and numerical parameters. Results of simulations were compared with the available experimental data. A significant sensitivity was recognized especially for changes of heat flux and mass flux. It was found out that the model is much less sensitive to changes of boundary conditions for high values of mass flux and heat flux than for low mass and heat fluxes. (author)

  15. Reconstruction of superthermal electron velocity distribution function from electron cyclotron spectra at down-shifted frequencies in tokamak T-10

    Directory of Open Access Journals (Sweden)

    Kukushkin A.B.

    2012-09-01

    Full Text Available A model is developed to quantitatively interpret the electron cyclotron (EC spectra in tokamak T-10 at frequencies lower than the first EC harmonic at the plasma edge. The model is based on the almost free propagation and isotropy of EC radiation in between the vacuum chamber wall and the cut-off zone in plasma. The inverse problem for the reconstruction of the velocity distribution function of superthermal electrons (in parallel and perpendicular momenta, and magnetic flux surfaces at the plasma edge is formulated and solved. It is shown that in the Ohmic discharges in the tokamak T-10 the superthermal electrons are the trapped particles at the low magnetic field side of toroid. Their mean kinetic energy lies in the range ~ 150-200 keV, and the density fraction is about ~ 10-4 relative to the main plasma.

  16. Distribution of velocity and turbulent characteristics in coarse-sediment laden flows above erodible plane bed in open channel

    Science.gov (United States)

    Zrostlík, Štěpán; Bareš, Vojtěch; Krupička, Jan; Picek, Tomáš; Matoušek, Václav

    2016-03-01

    Extreme conditions as flash floods in steep mobile-bed streams induce flows which carry a huge amount of sediment. Typically, the flow with the intense transport of sediment is stratified with a layered structure above an erodible plane bed. The paper deals with local flow characteristics in the layered structure of the two-phase flow composed of water and sediment. We present experimental data and results for two different fractions of plastic particles obtained using two acoustic Doppler methods and a Prandtl probe. The results contain vertical profiles of longitudinal velocity component and local turbulent characteristics of the flow as the Reynolds stress and turbulent intensity. The effect of the layered character of the flow on the flow characteristics is discussed. Special attention is paid to the distribution of Reynolds stress in the sediment-rich transport layer above the bed and to the evaluation of ability of carrier turbulent eddies to support sediment grains in and above the transport layer.

  17. Axon density and axon orientation dispersion in children born preterm

    NARCIS (Netherlands)

    Kelly, Claire E.; Thompson, Deanne K.; Chen, Jian; Leemans, Alexander; Adamson, Christopher L.; Inder, Terrie E.; Cheong, Jeanie L Y; Doyle, Lex W.; Anderson, Peter J.

    2016-01-01

    Background Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density

  18. Outsourcing CREB translation to axons to survive

    OpenAIRE

    Lin, Andrew C; Holt, Christine E.

    2008-01-01

    Nerve growth factor induces sensory neuron survival via retrograde signalling from the axon to the cell body. Local translation of the transcription factor CREB in the axon, followed by its transport to the nucleus, is involved in this process.

  19. Involvement of SARA in Axon and Dendrite Growth.

    Science.gov (United States)

    Arias, Cristina Isabel; Siri, Sebastián Omar; Conde, Cecilia

    2015-01-01

    SARA (Smad Anchor for Receptor Activation) plays a crucial role in Rab5-mediated endocytosis in cell lines localizing to early endosomes where it regulates morphology and function. Here, we analyzed the role of SARA during neuronal development and tested whether it functions as a regulator of endocytic trafficking of selected axonal and membrane proteins. Suppression of SARA perturbs the appearance of juxtanuclear endocytic recycling compartments and the neurons show long axons with large growth cones. Furthermore, surface distribution of the cell adhesion molecule L1 in axons and the fusion of vesicles containing transferring receptor (TfR) in dendrites were increased in neurons where SARA was silenced. Conversely, SARA overexpression generated large early endosomes and reduced neurite outgrowth. Taken together, our findings suggest a significant contribution of SARA to key aspects of neuronal development, including neurite formation. PMID:26405814

  20. 3D velocity distribution of P- and S-waves in a biotite gneiss, measured in oil as the pressure medium: Comparison with velocity measurements in a multi-anvil pressure apparatus and with texture-based calculated data

    Science.gov (United States)

    Lokajíček, T.; Kern, H.; Svitek, T.; Ivankina, T.

    2014-06-01

    Ultrasonic measurements of the 3D velocity distribution of P- and S-waves were performed on a spherical sample of a biotite gneiss from the Outokumpu scientific drill hole. Measurements were done at room temperature and pressures up to 400 and 70 MPa, respectively, in a pressure vessel with oil as a pressure medium. A modified transducer/sample assembly and the installation of a new mechanical system allowed simultaneous measurements of P- and S-wave velocities in 132 independent directions of the sphere on a net in steps of 15°. Proper signals for P- and S-waves could be recorded by coating the sample surface with a high-viscosity shear wave gel and by temporal point contacting of the transmitter and receiver transducers with the sample surface during the measurements. The 3D seismic measurements revealed a strong foliation-related directional dependence (anisotropy) of P- and S-wave velocities, which is confirmed by measurements in a multi-anvil apparatus on a cube-shaped specimen of the same rock. Both experimental approaches show a marked pressure sensitivity of P- and S-wave velocities and velocity anisotropies. With increasing pressure, P- and S-wave velocities increase non-linearly due to progressive closure of micro-cracks. The reverse is true for velocity anisotropy. 3D velocity calculations based on neutron diffraction measurements of crystallographic preferred orientation (CPO) of major minerals show that the intrinsic bulk anisotropy is basically caused by the CPO of biotite constituting about 23 vol.% of the rock. Including the shape of biotite grains and oriented low-aspect ratio microcracks into the modelling increases bulk anisotropy. An important finding from this study is that the measurements on the sample sphere and on the sample cube displayed distinct differences, particularly in shear wave velocities. It is assumed that the differences are due to the different geometries of the samples and the configuration of the transducer-sample assembly

  1. Structure of the velocity distribution of sheath-accelerated secondary electrons in an asymmetric RF-dc discharge

    Science.gov (United States)

    Khrabrov, Alexander V.; Kaganovich, Igor D.; Ventzek, Peter L. G.; Ranjan, Alok; Chen, Lee

    2015-10-01

    Low-pressure capacitively-coupled discharges with additional dc bias applied to a separate electrode are utilized in plasma-assisted etching for semiconductor device manufacturing. Measurements of the electron velocity distribution function (EVDF) of the flux impinging on the wafer, as well as in the plasma bulk, show a thermal population and additional peaks within a broad range of energies. That range extends from the thermal level up to the value for the ‘ballistic’ peak, corresponding to the bias potential. The non-thermal electron flux has been correlated to alleviating the electron shading effect and providing etch-resistance properties to masking photoresist layers. ‘Middle-energy peak electrons’ at energies of several hundred eV may provide an additional sustaining mechanism for the discharge. These features in the electron velocity (or energy) distribution functions are possibly caused by secondary electrons emitted from the electrodes and interacting with two high-voltage sheaths: a stationary sheath at the dc electrode and an oscillating self-biased sheath at the powered electrode. Since at those energies the mean free path for large-angle scattering (momentum relaxation length) is comparable to, or exceeds the size of the discharge gap, these ‘ballistic’ electrons will not be fully scattered by the background gas as they traverse the inter-electrode space. We have performed test-particle simulations in which the features in the EVDF of electrons impacting the RF electrode are fully resolved at all energies. An analytical model has been developed to predict existence of peaked and step-like structures in the EVDF. Those features can be explained by analyzing the kinematics of electron trajectories in the discharge gap. Step-like structures in the EVDF near the powered electrode appear due to accumulation of electrons emitted from the dc electrode within a portion of the RF cycle, and their subsequent release. Trapping occurs when the RF

  2. The VLT-FLAMES Tarantula Survey. X. Evidence for a bimodal distribution of rotational velocities for the single early B-type stars

    Science.gov (United States)

    Dufton, P. L.; Langer, N.; Dunstall, P. R.; Evans, C. J.; Brott, I.; de Mink, S. E.; Howarth, I. D.; Kennedy, M.; McEvoy, C.; Potter, A. T.; Ramírez-Agudelo, O. H.; Sana, H.; Simón-Díaz, S.; Taylor, W.; Vink, J. S.

    2013-02-01

    Aims: Projected rotational velocities (vesini) have been estimated for 334 targets in the VLT-FLAMES Tarantula Survey that do not manifest significant radial velocity variations and are not supergiants. They have spectral types from approximately O9.5 to B3. The estimates have been analysed to infer the underlying rotational velocity distribution, which is critical for understanding the evolution of massive stars. Methods: Projected rotational velocities were deduced from the Fourier transforms of spectral lines, with upper limits also being obtained from profile fitting. For the narrower lined stars, metal and non-diffuse helium lines were adopted, and for the broader lined stars, both non-diffuse and diffuse helium lines; the estimates obtained using the different sets of lines are in good agreement. The uncertainty in the mean estimates is typically 4% for most targets. The iterative deconvolution procedure of Lucy has been used to deduce the probability density distribution of the rotational velocities. Results: Projected rotational velocities range up to approximately 450 km s-1 and show a bi-modal structure. This is also present in the inferred rotational velocity distribution with 25% of the sample having 0 ≤ ve ≤ 100 km s-1 and the high velocity component having ve ~ 250 km s-1. There is no evidence from the spatial and radial velocity distributions of the two components that they represent either field and cluster populations or different episodes of star formation. Be-type stars have also been identified. Conclusions: The bi-modal rotational velocity distribution in our sample resembles that found for late-B and early-A type stars. While magnetic braking appears to be a possible mechanism for producing the low-velocity component, we can not rule out alternative explanations. Tables 3 and 4 are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/550/A109

  3. Gogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling.

    Directory of Open Access Journals (Sweden)

    Irina Hein

    Full Text Available BACKGROUND: Topographic maps form the basis of neural processing in sensory systems of both vertebrate and invertebrate species. In the Drosophila visual system, neighboring R1-R6 photoreceptor axons innervate adjacent positions in the first optic ganglion, the lamina, and thereby represent visual space as a continuous map in the brain. The mechanisms responsible for the establishment of retinotopic maps remain incompletely understood. RESULTS: Here, we show that the receptor Golden goal (Gogo is required for R axon lamina targeting and cartridge elongation in a partially redundant fashion with local guidance cues provided by neighboring axons. Loss of function of Gogo in large clones of R axons results in aberrant R1-R6 fascicle spacing. Gogo affects target cartridge selection only indirectly as a consequence of the disordered lamina map. Interestingly, small clones of gogo deficient R axons perfectly integrate into a proper retinotopic map suggesting that surrounding R axons of the same or neighboring fascicles provide complementary spatial guidance. Using single photoreceptor type rescue, we show that Gogo expression exclusively in R8 cells is sufficient to mediate targeting of all photoreceptor types in the lamina. Upon lamina targeting and cartridge selection, R axons elongate within their individual cartridges. Interestingly, here Gogo prevents bundling of extending R1-6 axons. CONCLUSION: Taken together, we propose that Gogo contributes to retinotopic map formation in the Drosophila lamina by controlling the distribution of R1-R6 axon fascicles. In a later developmental step, the regular position of R1-R6 axons along the lamina plexus is crucial for target cartridge selection. During cartridge elongation, Gogo allows R1-R6 axons to extend centrally in the lamina cartridge.

  4. TEGENA: Detailed experimental investigations of temperature and velocity distributions in rod bundle geometries with turbulent sodium flow

    International Nuclear Information System (INIS)

    Precise knowlege of the velocity and temperature distributions is necessary in fuel element design (rod bundles with longitudinal flow). The detail codes required in the fine analysis of non-uniformly cooled bundle zones are presently at the stage of development. In order to verify these computer codes, the mean fluid temperatures and the related RMS values of the temperature fluctuations were measured in a heated bundle, TEGENA, containing four rods arranged in one row (P/D = W/D = 1.147) with sodium cooling (Pr≅0.005). The temperature distribution in the structures was determined as the necessary boundary condition for the temperature profiles in the fluid. The experiments were carried out with different types of heating (uniform load and flux tilting) and the flow conditions were varied in the ranges 4000≤Re≤76,000; 20≤Pe≤400. The essential processes of thermal development took place under uniform load within a heated bundle length of about 100 hydraulic diameters. In the main measuring plane at the end of the heated zone, after 200 hydraulic diameters, the flow can be termed largely developed thermally. There, the temperature profiles measured in the fluid exhibit pronounced maxima in the narrowest gaps of the subchannels as well as pronounced minima in the centers of the subchannels at the unheated wall. In the zones of maximum temperature gradients the temperature fluctuations attain maximum and minimum values, respectively, at the points of disappearance of the temperature gradients. In all cases of flux tilting investigated the flow at the end of the heated zone had not yet developed thermally. (orig.)

  5. Influence of elastic scattering on the anisotropy of the electron velocity distribution in weakly ionized krypton and xenon plasmas

    International Nuclear Information System (INIS)

    The aim of the present paper is to elucidate, by solving the Boltzmann equation (BE), the impact of anisotropic elastic electron-neutral (e-n) scattering on the electron velocity distribution (EVD) in weakly ionized, steady-state, collision-dominated plasma placed in external d.c. electric field. For such a study krypton and xenon make a most convenient choice: they are the preferred, if not indispensable, filling gases in various gas-discharge devices, and therefore important for applications on one hand, and the differential elastic cross section for both e-Kr and e-Xe scattering shows a remarkable dependence on the scattering angle, on the other. Attention is focused on the low-energy interval up to 10 eV where the elastic e-n collisions are dominant and the inelastic ones as rather infrequent can be safely neglected. This is also the energy range within which both a deep Ramsauer-Townsend (RT) minimum (at around 0.6-0.7 eV) and a subsequent maximum occur in all the relevant integral cross sections for e-Kr and e-Xe elastic scattering. The electron scattering on both targets has been widely studied and reliable and accurate collision data are available. The results illustrate well how the assumption of isotropic scattering seriously undermines the collision-induced anisotropy of the electron energy distribution function (EEDF). Anisotropic elastic scattering enriches the electron population at higher energies, and rises the rate of power input to the electron component. It is also apparent that for the understanding of the kinetic processes around the RT minimum and their accurate description the two term approximation for the EEDF is likely to be insufficient

  6. A model of fasciculation and sorting in mixed populations of axons

    CERN Document Server

    Chaudhuri, Debasish; Zapotocky, Martin

    2010-01-01

    We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)), aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions. To mimic turnover of axons, whole paths are removed and new walkers are injected with specified rates. In the simplest version of the model, we use strongly adhesive inter-axon interactions that are identical for all pairs of axons. We generalize the model to interactions of finite strengths and to multiple types of axons with type-specific interactions. The dynamic steady state is characterized by the position-dependent distribution of fascicle sizes. With distance in the direction of axon growth, the mean fascicle size and emergent time scales grow monotonically, while the degree of sorting of fascicles by axon type has a maximum at a finite distance. To understand the emergence of slow time scales, we develop an analytical framework to analyz...

  7. Distribution of velocity and turbulent characteristics in coarse-sediment laden flows above erodible plane bed in open channel

    Directory of Open Access Journals (Sweden)

    Zrostlík Štěpán

    2016-01-01

    Full Text Available Extreme conditions as flash floods in steep mobile-bed streams induce flows which carry a huge amount of sediment. Typically, the flow with the intense transport of sediment is stratified with a layered structure above an erodible plane bed. The paper deals with local flow characteristics in the layered structure of the two-phase flow composed of water and sediment. We present experimental data and results for two different fractions of plastic particles obtained using two acoustic Doppler methods and a Prandtl probe. The results contain vertical profiles of longitudinal velocity component and local turbulent characteristics of the flow as the Reynolds stress and turbulent intensity. The effect of the layered character of the flow on the flow characteristics is discussed. Special attention is paid to the distribution of Reynolds stress in the sediment-rich transport layer above the bed and to the evaluation of ability of carrier turbulent eddies to support sediment grains in and above the transport layer.

  8. The Origin of Non-Maxwellian Solar Wind Electron Velocity Distribution Function: Connection to Nanoflares in the Solar Corona

    CERN Document Server

    Che, H

    2014-01-01

    The formation of the observed core-halo feature in the solar wind electron velocity distribution function is a long-time puzzle. In this letter based on the current knowledge of nanoflares we show that the nanoflare-accelerated electron beams are likely to trigger a strong electron two-stream instability that generates kinetic Alfv\\'en wave and whistler wave turbulence, as we demonstrated in a previous paper. We further show that the core-halo feature produced during the origin of kinetic turbulence is likely to originate in the inner corona and can be preserved as the solar wind escapes to space along open field lines. We formulate a set of equations to describe the heating processes observed in the simulation and show that the core-halo temperature ratio of the solar wind is insensitive to the initial conditions in the corona and is related to the core-halo density ratio of the solar wind and to the quasi-saturation property of the two-stream instability at the time when the exponential decay ends. This rel...

  9. Extension of charge-state-distribution calculations for ion-solid collisions towards low velocities and many-electron ions

    Science.gov (United States)

    Lamour, E.; Fainstein, P. D.; Galassi, M.; Prigent, C.; Ramirez, C. A.; Rivarola, R. D.; Rozet, J.-P.; Trassinelli, M.; Vernhet, D.

    2015-10-01

    Knowledge of the detailed evolution of the whole charge-state distribution of projectile ions colliding with targets is required in several fields of research such as material science and atomic and nuclear physics but also in accelerator physics, and in particular in regard to the several foreseen large-scale facilities. However, there is a lack of data for collisions in the nonperturbative energy domain and that involve many-electron projectiles. Starting from the etacha model we developed [Rozet et al., Nucl. Instrum. Methods Phys. Res., Sect. B 107, 67 (1996), 10.1016/0168-583X(95)00800-4], we present an extension of its validity domain towards lower velocities and larger distortions. Moreover, the system of rate equations is able to take into account ions with up to 60 orbital states of electrons. The computed data from the different new versions of the etacha code are compared to some test collision systems. The improvements made are clearly illustrated by 28.9 MeV u-1P b56 + ions, and laser-generated carbon ion beams of 0.045 to 0.5 MeV u-1 , passing through carbon or aluminum targets, respectively. Hence, those new developments can efficiently sustain the experimental programs that are currently in progress on the "next-generation" accelerators or laser facilities.

  10. Axonal degeneration affects muscle density in older men and women.

    Science.gov (United States)

    Lauretani, Fulvio; Bandinelli, Stefania; Bartali, Benedetta; Di Iorio, Angelo; Giacomini, Vittoria; Corsi, Anna Maria; Guralnik, Jack M; Ferrucci, Luigi

    2006-08-01

    Using data from InCHIANTI, a prospective population-based survey of older persons, we examined the relationship of peroneal nerve conduction velocity (NCV, a measure of nerve myelination) and compound muscle action potential (CMAP, a measure of axonal degeneration) with calf muscle mass and density, two complementary measures of sarcopenia. NCV and CMAP were assessed by surface electroneurography of the right peroneal nerve conducted in 1162 participants, 515 men and 647 women, age 21-96 years, free of major neurological diseases. Cross-sectional muscle area and calf muscle density were measured using peripheral quantitative computerized tomography (pQCT). Both nerve and muscle parameters declined with age although in most cases the decline was not linear. In both sexes, CMAP, but not NCV, was independently and significantly associated with calf muscle density. These findings suggest that intrinsic changes in the muscle tissue are partially caused by a reduction in the number of motor axons. PMID:16085338

  11. Isolation and analyses of axonal ribonucleoprotein complexes.

    Science.gov (United States)

    Doron-Mandel, Ella; Alber, Stefanie; Oses, Juan A; Medzihradszky, Katalin F; Burlingame, Alma L; Fainzilber, Mike; Twiss, Jeffery L; Lee, Seung Joon

    2016-01-01

    Cytoskeleton-dependent RNA transport and local translation in axons are gaining increased attention as key processes in the maintenance and functioning of neurons. Specific axonal transcripts have been found to play roles in many aspects of axonal physiology including axon guidance, axon survival, axon to soma communication, injury response and regeneration. This axonal transcriptome requires long-range transport that is achieved by motor proteins carrying transcripts as messenger ribonucleoprotein (mRNP) complexes along microtubules. Other than transport, the mRNP complex plays a major role in the generation, maintenance, and regulation of the axonal transcriptome. Identification of axonal RNA-binding proteins (RBPs) and analyses of the dynamics of their mRNPs are of high interest to the field. Here, we describe methods for the study of interactions between RNA and proteins in axons. First, we describe a protocol for identifying binding proteins for an RNA of interest by using RNA affinity chromatography. Subsequently, we discuss immunoprecipitation (IP) methods allowing the dissection of protein-RNA and protein-protein interactions in mRNPs under various physiological conditions. PMID:26794529

  12. Comparison of 1D PDA sampling methods to obtain drop size and velocity distributions inside a spray cone of agricultural nozzles

    OpenAIRE

    Holterman, H.J.

    2009-01-01

    In agriculture, spray drift research is carried out in field experiments and by computer simulation. Regarding the latter approach, accurate knowledge of the initial spray is required. Not only is the overall drop size distribution of the spray an important factor in the spraying process, but also its local variation within the spray cone below a nozzle. Furthermore, the velocity distribution of drops in the spray cone has to be considered, which is a function of drop size and location in the...

  13. Angular and velocity distributions of secondary particles emitted in interaction of 3. 6-GeV/nucleon. cap alpha. particles and lead nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Antonenko, V.G.; Vinogradov, A.A.; Galitskii, V.M.; Grigor' yan, Y.I.; Ippolitov, M.S.; Karadzhev, K.V.; Kuz' min, E.A.; Man' ko, V.I.; Ogloblin, A.A.; Paramonov, V.V.; Tsvetkov, A.A.

    1980-04-01

    The technique is described and results presented of measurements of the velocity and angular distributions of pions, protons, and deuterons, and tritons emitted in bombardment of lead nuclei by ..cap alpha.. particles with energy 3.6 GeV/nucleon.

  14. Crossed laser and molecular beam study of multiphoton dissociation of C/sub 2/F/sub 5/Cl. [Rate constants, angular and velocity distributions

    Energy Technology Data Exchange (ETDEWEB)

    Krajnovich, D.J.; Giardini-Guidoni, A.; Sudboe, A.S.; Schulz, P.A.; Shen, Y.R.; Lee, Y.T.

    1978-09-01

    Rate constants for the photodissociation of C/sub 2/F/sub 5/Cl as well as the yield of C/sub 2/F/sub 4//sup +/ were measured. The dynamics of the two dissociation channels was studied by measuring the angular and velocity distributions of the products. 2 references. (JFP)

  15. Angular and velocity distributions of small cluster fragments in neutral (NH{sub 3}){sub n} scattering off LiF(100)

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, C.; Zacharias, H. [Physikalisches Institut, Westfaelische Wilhelms-Universitaet, D-48149 Muenster (Germany); Baumfalk, R. [Max-Planck-Institut fuer Stroemungsforschung, D-37073 Goettingen (Germany)

    1998-12-15

    The scattering of neutral ammonia clusters off a LiF(100) surface is studied. A supersonic expansion of ammonia and ammonia seeded in Kr and He produces clusters of various sizes but uniform kinetic energies of 176, 57 and 285 meV per monomer molecule, respectively. The mass distribution of scattered particles is measured in a reflecting time-of-flight mass spectrometer using single-photon photoionization with vacuum ultraviolet (VUV) laser radiation at {lambda}=118 nm (h{nu}=10.49 eV). While in the incident beam (NH{sub 3}){sub n} clusters up to n=65 can be detected, the mass spectrum of the scattered particles is dominated by NH{sub 3}{sup +}, and only a few small clusters are found. Angular distributions of these fragments show that the maximum of the scattered intensity shifts to greater detection angles for increasing fragment mass. Velocity distributions of released monomers are measured for all three cluster beams and found to be independent of the impact velocity of the clusters. The velocity distributions of scattered fragments larger than NH{sub 3}{sup +} show a decreasing width with increasing fragment size and a most probable velocity slightly higher than that of the monomer molecules. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  16. Micro manometer and pitot tube for measuring the velocity distribution in a natural convection water stream between two vertical parallel plates (1961)

    International Nuclear Information System (INIS)

    For heat transfer studies in certain cases of cooling in swimming-pool type nuclear reactors, a knowledge of the distribution of the velocities between two heating elements is of prime importance. A Pitot tube and a micro-manometer have been developed for making these measurements on an experimental model. (authors)

  17. Measurement of a 2D fast-ion velocity distribution function by tomographic inversion of fast-ion D-alpha spectra

    DEFF Research Database (Denmark)

    Salewski, Mirko; Geiger, B.; Jacobsen, Asger Schou;

    2014-01-01

    We present the first measurement of a local fast-ion 2D velocity distribution function f(v‖, v⊥). To this end, we heated a plasma in ASDEX Upgrade by neutral beam injection and measured spectra of fast-ion Dα (FIDA) light from the plasma centre in three views simultaneously. The measured spectra ...

  18. Injury predictors for traumatic axonal injury in a rodent head impact acceleration model.

    Science.gov (United States)

    Li, Yan; Zhang, Liying; Kallakuri, Srinivasu; Zhou, Runzhou; Cavanaugh, John M

    2011-11-01

    A modified Marmarou impact acceleration injury model was developed to study the kinematics of the rat head to quantify traumatic axonal injury (TAI) in the corpus callosum (CC) and brainstem pyramidal tract (Py), to determine injury predictors and to establish injury thresholds for severe TAI. Thirty-one anesthetized male Sprague-Dawley rats (392±13 grams) were impacted using a modified impact acceleration injury device from 2.25 m and 1.25 m heights. Beta-amyloid precursor protein (β-APP) immunocytochemistry was used to assess and quantify axonal changes in CC and Py. Over 600 injury maps in CC and Py were constructed in the 31 impacted rats. TAI distribution along the rostro-caudal direction in CC and Py was determined. Linear and angular responses of the rat head were monitored and measured in vivo with an attached accelerometer and angular rate sensor, and were correlated to TAI data. Logistic regression analysis suggested that the occurrence of severe TAI in CC was best predicted by average linear acceleration, followed by power and time to surface righting. The combination of average linear acceleration and time to surface righting showed an improved predictive result. In Py, severe TAI was best predicted by time to surface righting, followed by peak and average angular velocity. When both CC and Py were combined, power was the best predictor, and the combined average linear acceleration and average angular velocity was also found to have good injury predictive ability. Receiver operator characteristic curves were used to assess the predictive power of individual and paired injury predictors. TAI tolerance curves were also proposed in this study. PMID:22869303

  19. The 3-D distribution of random velocity inhomogeneities in southwestern Japan and the western part of the Nankai subduction zone

    Science.gov (United States)

    Takahashi, Tsutomu; Obana, Koichiro; Yamamoto, Yojiro; Nakanishi, Ayako; Kodaira, Shuichi; Kaneda, Yoshiyuki

    2013-05-01

    waves at high frequencies (>1 Hz) show collapsed and broadened wave trains caused by multiple scattering in the lithosphere. This study analyzed the envelopes of direct S waves in southwestern Japan and on the western side of the Nankai trough and estimated the spatial distribution of random inhomogeneities by assuming a von Kármán type power spectral density function (PSDF). Strongly inhomogeneous media have been mostly imaged at shallow depth (0-20 km depth) in the onshore area of southwestern Japan, and their PSDF is represented as P(m) ≈ 0.05m-3.7 km3, with m being the spatial wave number, whereas most of the other area shows weak inhomogeneities of which PSDF is P(m) ≈ 0.005m-4.5 km3. At Hyuga-nada in Nankai trough, there is an anomaly of inhomogeneity of which PSDF is estimated as P(m) ≈ 0.01m-4.5 km3. This PSDF has the similar spectral gradient with the weakly inhomogeneous media, but has larger power spectral density than other offshore areas. This anomalous region is broadly located in the subducted Kyushu Palau ridge, which was identified by using velocity structures and bathymetry, and it shows no clear correlation with the fault zones of large earthquakes in past decades. These spatial correlations suggest that possible origins of inhomogeneities at Hyuga-nada are ancient volcanic activity in the oceanic plate or deformed structures due to the subduction of the Kyushu Palau ridge.

  20. Traction Force and Tension Fluctuations During Axon Growth

    Directory of Open Access Journals (Sweden)

    Jamison ePolackwich

    2015-10-01

    Full Text Available Actively generated mechanical forces play a central role in axon growthand guidance, but the mechanisms that underly force generation andregulation in growing axons remain poorly understood. We reportmeasurements of the dynamics of traction stresses from growth cones ofactively advancing axons from postnatal rat DRG neurons. By tracking themovement of the growth cone and analyzing the traction stress field froma reference frame that moves with it, we are able to show that there isa clear and consistent average stress field that underlies the complexspatial stresses present at any one time. The average stress field hasstrong maxima on the sides of the growth cone, directed inward towardthe growth cone neck. This pattern represents a contractile stresscontained within the growth cone, and a net force that is balanced bythe axon tension. Using high time-resolution measurements of the growthcone traction stresses, we show that the stress field is composed offluctuating local stress peaks, with a large number peaks that live fora short time, a population of peaks whose lifetime distribution followsan exponential decay, and a small number of very long-lived peaks. Weshow that the high time-resolution data also reveal that the tensionappears to vary randomly over short time scales, roughly consistent withthe lifetime of the stress peaks, suggesting that the tensionfluctuations originate from stochastic adhesion dynamics.

  1. Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone

    Directory of Open Access Journals (Sweden)

    Ginny G. Farías

    2015-11-01

    Full Text Available Polarized sorting of newly synthesized proteins to the somatodendritic and axonal domains of neurons occurs by selective incorporation into distinct populations of vesicular transport carriers. An unresolved issue is how the vesicles themselves are sorted to their corresponding neuronal domains. Previous studies concluded that the axon initial segment (AIS is an actin-based filter that selectively prevents passage of somatodendritic vesicles into the axon. We find, however, that most somatodendritic vesicles fail to enter the axon at a more proximal region in the axon hillock, herein referred to as the pre-axonal exclusion zone (PAEZ. Forced coupling of a somatodendritic cargo protein to an axonally directed kinesin is sufficient to drive transport of whole somatodendritic vesicles through the PAEZ toward the distal axon. Based on these findings, we propose that polarized sorting of transport vesicles occurs at the PAEZ and depends on the ability of the vesicles to acquire an appropriately directed microtubule motor.

  2. Coordinating gene expression and axon assembly to control axon growth: potential role of GSK3 signaling

    Directory of Open Access Journals (Sweden)

    Fengquan Zhou

    2012-02-01

    Full Text Available Axon growth requires coordinated regulation of gene expression in the neuronal soma, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3 signaling has recently been shown to play key roles in regulation of axonal transport and cytoskeletal assembly during axon growth. GSK3 signaling is also known to regulate gene expression via controlling the functions of many transcription factors, suggesting that GSK3 may be an important regulator of gene transcription supporting axon growth. Here we will review signaling pathways that control local axon assembly at the growth cone and gene expression in the soma during developmental or regenerative axon growth and discuss the potential involvement of GSK3 signaling in these processes, with a particular focus on how GSK3 signaling modulates the function of axon growth-associated transcription factors.

  3. Variation of the neurofilament medium KSP repeat sub-domain across mammalian species: implications for altering axonal structure.

    Science.gov (United States)

    Barry, D M; Carpenter, C; Yager, C; Golik, B; Barry, K J; Shen, H; Mikse, O; Eggert, L S; Schulz, D J; Garcia, M L

    2010-01-01

    The evolution of larger mammals resulted in a corresponding increase in peripheral nerve length. To ensure optimal nervous system functionality and survival, nerve conduction velocities were likely to have increased to maintain the rate of signal propagation. Increases of conduction velocities may have required alterations in one of the two predominant properties that affect the speed of neuronal transmission: myelination or axonal diameter. A plausible mechanism to explain faster conduction velocities was a concomitant increase in axonal diameter with evolving axonal length. The carboxy terminal tail domain of the neurofilament medium subunit is a determinant of axonal diameter in large caliber myelinated axons. Sequence analysis of mammalian orthologs indicates that the neurofilament medium carboxy terminal tail contains a variable lysine-serine-proline (KSP) repeat sub-domain flanked by two highly conserved sub-domains. The number of KSP repeats within this region of neurofilament medium varies among species. Interestingly, the number of repeats does not change within a species, suggesting that selective pressure conserved the number of repeats within a species. Mapping KSP repeat numbers onto consensus phylogenetic trees reveals independent KSP expansion events across several mammalian clades. Linear regression analyses identified three subsets of mammals, one of which shows a positive correlation in the number of repeats with head-body length. For this subset of mammals, we hypothesize that variations in the number of KSP repeats within neurofilament medium carboxy terminal tail may have contributed to an increase in axonal caliber, increasing nerve conduction velocity as larger mammals evolved. PMID:20008369

  4. Quantitative measurements and modeling of cargo–motor interactions during fast transport in the living axon

    International Nuclear Information System (INIS)

    The kinesins have long been known to drive microtubule-based transport of sub-cellular components, yet the mechanisms of their attachment to cargo remain a mystery. Several different cargo-receptors have been proposed based on their in vitro binding affinities to kinesin-1. Only two of these—phosphatidyl inositol, a negatively charged lipid, and the carboxyl terminus of the amyloid precursor protein (APP-C), a trans-membrane protein—have been reported to mediate motility in living systems. A major question is how these many different cargo, receptors and motors interact to produce the complex choreography of vesicular transport within living cells. Here we describe an experimental assay that identifies cargo–motor receptors by their ability to recruit active motors and drive transport of exogenous cargo towards the synapse in living axons. Cargo is engineered by derivatizing the surface of polystyrene fluorescent nanospheres (100 nm diameter) with charged residues or with synthetic peptides derived from candidate motor receptor proteins, all designed to display a terminal COOH group. After injection into the squid giant axon, particle movements are imaged by laser-scanning confocal time-lapse microscopy. In this report we compare the motility of negatively charged beads with APP-C beads in the presence of glycine-conjugated non-motile beads using new strategies to measure bead movements. The ensuing quantitative analysis of time-lapse digital sequences reveals detailed information about bead movements: instantaneous and maximum velocities, run lengths, pause frequencies and pause durations. These measurements provide parameters for a mathematical model that predicts the spatiotemporal evolution of distribution of the two different types of bead cargo in the axon. The results reveal that negatively charged beads differ from APP-C beads in velocity and dispersion, and predict that at long time points APP-C will achieve greater progress towards the presynaptic

  5. Axonal regeneration through arterial grafts.

    OpenAIRE

    Anderson, P. N.; Turmaine, M.

    1986-01-01

    The left common peroneal nerves of adult inbred mice were severed and allowed to regenerate through the lumina of Y-shaped tubes comprising grafts of abdominal aorta and its bifurcation. Very little regeneration took place within the grafts unless the distal nerve stump was inserted into one limb of the Y-tube. Using syngeneic grafts virtually all the axons regenerating through the lumen grew down the limb of the Y-tube containing the distal nerve. Using non-syngeneic grafts, however, a subst...

  6. Measurements of water distributions in in-plane direction of a PEFC by using neutron radiography and analysis of gas-velocity distributions in the channel and the GDL

    International Nuclear Information System (INIS)

    Visualization and measurement of water distributions in a polymer electrolyte fuel cell (PEFC) were carried out by means of neutron radiography for clarifying water effects on the performances. The two-dimensional water distributions were applied for a network model. It analyzes the gas-velocity distributions depending on the local pressure drop which is affected by the gas-flow rate and the water accumulation. Formation of the accumulated water in the channel was assumed based on measurement results of water distributions in through-plane direction. Furthermore, it was estimated that maximum water accumulation in the gas diffusion layer (GDL) and mechanism of water discharge from the GDL to the channel. From the analysis results, change of gas-velocity distributions depending on the water accumulation in the PEFC could be obtained. (author)

  7. Axonal interferon responses and alphaherpesvirus neuroinvasion

    Science.gov (United States)

    Song, Ren

    Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at a peripheral epithelial surface and continues into the peripheral nervous system (PNS) that innervates this tissue. Inflammatory responses are induced at the infected peripheral site prior to viral invasion of the PNS. PNS neurons are highly polarized cells with long axonal processes that connect to distant targets. When the peripheral tissue is first infected, only the innervating axons are exposed to this inflammatory milieu, which include type I interferon (e.g. IFNbeta) and type II interferon (i.e. IFNgamma). IFNbeta can be produced by all types of cells, while IFNgamma is secreted by some specific types of immune cells. And both types of IFN induce antiviral responses in surrounding cells that express the IFN receptors. The fundamental question is how do PNS neurons respond to the inflammatory milieu experienced only by their axons. Axons must act as potential front-line barriers to prevent PNS infection and damage. Using compartmented cultures that physically separate neuron axons from cell bodies, I found that pretreating isolated axons with IFNbeta or IFNgamma significantly diminished the number of HSV-1 and PRV particles moving from axons to the cell bodies in an IFN receptor-dependent manner. Furthermore, I found the responses in axons are activated differentially by the two types of IFNs. The response to IFNbeta is a rapid, axon-only response, while the response to IFNgamma involves long distance signaling to the PNS cell body. For example, exposing axons to IFNbeta induced STAT1 phosphorylation (p-STAT1) only in axons, while exposure of axons to IFNgamma induced p-STAT1 accumulation in distant cell body nuclei. Blocking transcription in cell bodies eliminated IFNgamma-, but not IFNbeta-mediated antiviral effects. Proteomic analysis of IFNbeta- or IFNgamma-treated axons identified several differentially regulated proteins. Therefore

  8. Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.

    Directory of Open Access Journals (Sweden)

    Fabrice Ango

    2008-04-01

    Full Text Available The geometric and subcellular organization of axon arbors distributes and regulates electrical signaling in neurons and networks, but the underlying mechanisms have remained elusive. In rodent cerebellar cortex, stellate interneurons elaborate characteristic axon arbors that selectively innervate Purkinje cell dendrites and likely regulate dendritic integration. We used GFP BAC transgenic reporter mice to examine the cellular processes and molecular mechanisms underlying the development of stellate cell axons and their innervation pattern. We show that stellate axons are organized and guided towards Purkinje cell dendrites by an intermediate scaffold of Bergmann glial (BG fibers. The L1 family immunoglobulin protein Close Homologue of L1 (CHL1 is localized to apical BG fibers and stellate cells during the development of stellate axon arbors. In the absence of CHL1, stellate axons deviate from BG fibers and show aberrant branching and orientation. Furthermore, synapse formation between aberrant stellate axons and Purkinje dendrites is reduced and cannot be maintained, leading to progressive atrophy of axon terminals. These results establish BG fibers as a guiding scaffold and CHL1 a molecular signal in the organization of stellate axon arbors and in directing their dendritic innervation.

  9. Neurofilament spacing, phosphorylation, and axon diameter in regenerating and uninjured lamprey axons.

    Science.gov (United States)

    Pijak, D S; Hall, G F; Tenicki, P J; Boulos, A S; Lurie, D I; Selzer, M E

    1996-05-13

    It has been postulated that phosphorylation of the carboxy terminus sidearms of neurofilaments (NFs) increases axon diameter through repulsive electrostatic forces that increase sidearm extension and interfilament spacing. To evaluate this hypothesis, the relationships among NF phosphorylation, NF spacing, and axon diameter were examined in uninjured and spinal cord-transected larval sea lampreys (Petromyzon marinus). In untransected animals, axon diameters in the spinal cord varied from 0.5 to 50 microns. Antibodies specific for highly phosphorylated NFs labeled only large axons (> 10 microns), whereas antibodies for lightly phosphorylated NFs labeled medium-sized and small axons more darkly than large axons. For most axons in untransected animals, diameter was inversely related to NF packing density, but the interfilament distances of the largest axons were only 1.5 times those of the smallest axons. In addition, the lightly phosphorylated NFs of the small axons in the dorsal columns were widely spaced, suggesting that phosphorylation of NFs does not rigidly determine their spacing and that NF spacing does not rigidly determine axon diameter. Regenerating neurites of giant reticulospinal axons (GRAs) have diameters only 5-10% of those of their parent axons. If axon caliber is controlled by NF phosphorylation via mutual electrostatic repulsion, then NFs in the slender regenerating neurites should be lightly phosphorylated and densely packed (similar to NFs in uninjured small caliber axons), whereas NFs in the parent GRAs should be highly phosphorylated and loosely packed. However, although linear density of NFs (the number of NFs per micrometer) in these slender regenerating neurites was twice that in their parent axons, they were highly phosphorylated. Following sectioning of these same axons close to the cell body, axon-like neurites regenerated ectopically from dendritic tips. These ectopically regenerating neurites had NF linear densities 2.5 times those of

  10. Disrupted axon-glia interactions at the paranode in myelinated nerves cause axonal degeneration and neuronal cell death in the aged Caspr mutant mouse shambling.

    Science.gov (United States)

    Takagishi, Yoshiko; Katanosaka, Kimiaki; Mizoguchi, Hiroyuki; Murata, Yoshiharu

    2016-07-01

    Emerging evidence suggests that axonal degeneration is a disease mechanism in various neurodegenerative diseases and that the paranodes at the nodes of Ranvier may be the initial site of pathogenesis. We investigated the pathophysiology of the disease process in the central and peripheral nervous systems of a Caspr mutant mouse, shambling (shm), which is affected by disrupted paranodal structures and impaired nerve conduction of myelinated nerves. The shm mice manifest a progressive neurological phenotype as mice age. We found extensive axonal degeneration and a loss of neurons in the central nervous system and peripheral nervous system in aged shm mice. Axonal alteration of myelinated nerves was defined by abnormal distribution and expression of neurofilaments and derangements in the status of phosphorylated and non/de-phosphorylated neurofilaments. Autophagy-related structures were also accumulated in degenerated axons and neurons. In conclusion, our results suggest that disrupted axon-glia interactions at the paranode cause the cytoskeletal alteration in myelinated axons leading to neuronal cell death, and the process involves detrimental autophagy and aging as factors that promote the pathogenesis. PMID:27255813

  11. Axon reflexes in human cold exposed fingers

    NARCIS (Netherlands)

    Daanen, H.A.M.; Ducharme, M.B.

    2000-01-01

    Exposure of fingers to severe cold induces cold induced vasodilation (CIVD). The mechanism of CIVD is still debated. The original theory states that an axon reflex causes CIVD. To test this hypothesis, axon reflexes were evoked by electrical stimulation of the middle fingers of hands immersed in wat

  12. Neuronal Development: SAD Kinases Make Happy Axons

    OpenAIRE

    Xing, Lei; Newbern, Jason M.; Snider, William D

    2013-01-01

    The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development — arborization in the target field.

  13. Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.

    Directory of Open Access Journals (Sweden)

    Eleanna Stamatakou

    Full Text Available Upon arrival at their synaptic targets, axons slow down their growth and extensively remodel before the assembly of presynaptic boutons. Wnt proteins are target-derived secreted factors that promote axonal remodelling and synaptic assembly. In the developing spinal cord, Wnts secreted by motor neurons promote axonal remodelling of NT-3 responsive dorsal root ganglia neurons. Axon remodelling induced by Wnts is characterised by growth cone pausing and enlargement, processes that depend on the re-organisation of microtubules. However, the contribution of the actin cytoskeleton has remained unexplored. Here, we demonstrate that Wnt3a regulates the actin cytoskeleton by rapidly inducing F-actin accumulation in growth cones from rodent DRG neurons through the scaffold protein Dishevelled-1 (Dvl1 and the serine-threonine kinase Gsk3β. Importantly, these changes in actin cytoskeleton occurs before enlargement of the growth cones is evident. Time-lapse imaging shows that Wnt3a increases lamellar protrusion and filopodia velocity. In addition, pharmacological inhibition of actin assembly demonstrates that Wnt3a increases actin dynamics. Through a yeast-two hybrid screen, we identified the actin-binding protein Eps8 as a direct interactor of Dvl1, a scaffold protein crucial for the Wnt signalling pathway. Gain of function of Eps8 mimics Wnt-mediated axon remodelling, whereas Eps8 silencing blocks the axon remodelling activity of Wnt3a. Importantly, blockade of the Dvl1-Eps8 interaction completely abolishes Wnt3a-mediated axonal remodelling. These findings demonstrate a novel role for Wnt-Dvl1 signalling through Eps8 in the regulation of axonal remodeling.

  14. Estimating neuronal connectivity from axonal and dendritic density fields

    Directory of Open Access Journals (Sweden)

    Jaap evan Pelt

    2013-11-01

    Full Text Available Neurons innervate space by extending axonal and dendritic arborizations. When axons and dendrites come in close proximity of each other, synapses between neurons can be formed. Neurons vary greatly in their morphologies and synaptic connections with other neurons. The size and shape of the arborizations determine the way neurons innervate space. A neuron may therefore be characterized by the spatial distribution of its axonal and dendritic 'mass'. A population mean 'mass' density field of a particular neuron type can be obtained by averaging over the individual variations in neuron geometries. Connectivity in terms of candidate synaptic contacts between neurons can be determined directly on the basis of their arborizations but also indirectly on the basis of their density fields. To decide when a candidate synapse can be formed, we previously developed a criterion defining that axonal and dendritic line pieces should cross in 3D and have an orthogonal distance less than a threshold value. In this paper, we developed new methodology for applying this criterion to density fields. We show that estimates of the number of contacts between neuron pairs calculated from their density fields are fully consistent with the number of contacts calculated from the actual arborizations. However, the estimation of the connection probability and the expected number of contacts per connection cannot be calculated directly from density fields, because density fields do not carry anymore the correlative structure in the spatial distribution of synaptic contacts. Alternatively, these two connectivity measures can be estimated from the expected number of contacts by using empirical mapping functions. The neurons used for the validation studies were generated by our neuron simulator NETMORPH. An example is given of the estimation of average connectivity and Euclidean pre- and postsynaptic distance distributions in a network of neurons represented by their population

  15. Early events in axon/dendrite polarization.

    Science.gov (United States)

    Cheng, Pei-lin; Poo, Mu-ming

    2012-01-01

    Differentiation of axons and dendrites is a critical step in neuronal development. Here we review the evidence that axon/dendrite formation during neuronal polarization depends on the intrinsic cytoplasmic asymmetry inherited by the postmitotic neuron, the exposure of the neuron to extracellular chemical factors, and the action of anisotropic mechanical forces imposed by the environment. To better delineate the functions of early signals among a myriad of cellular components that were shown to influence axon/dendrite formation, we discuss their functions by distinguishing their roles as determinants, mediators, or modulators and consider selective degradation of these components as a potential mechanism for axon/dendrite polarization. Finally, we examine whether these early events of axon/dendrite formation involve local autocatalytic activation and long-range inhibition, as postulated by Alan Turing for the morphogenesis of patterned biological structure. PMID:22715881

  16. Isotopic and velocity distributions of 83Bi produced in charge-pickup reactions of 20882PB at 1 A GeV

    International Nuclear Information System (INIS)

    Isotopically resolved cross sections and velocity distributions have been measured in charge-pickup reactions of 1 A GeV 208Pb with proton, deuterium and titanium target. The total and partial charge-pickup cross sections in the reactions 208Pb + 1H and 208Pb + 2H are measured to be the same in the limits of the error bars. A weak increase in the total charge-pickup cross section is seen in the reaction of 208Pb with the titanium target. The measured velocity distributions show different contributions - quasi-elastic scattering and Δ-resonance excitation - to the charge-pickup production. Data on total and partial charge-pickup cross sections from these three reactions are compared with other existing data and also with model calculations based on the coupling of different intra-nuclear cascade codes and an evaporation code. (orig.)

  17. Role of unsteady mechanisms in maintaining a nonuniform angular-velocity distribution through the depth of the solar convection zone

    Energy Technology Data Exchange (ETDEWEB)

    Zherbina, A.S.

    1977-01-01

    Unsteady rotation of a viscous convective layer with friction at its lower boundary is analyzed. Such friction is shown to be capable of maintaining a radial dependence of angular velocity for a long time. It is found, however, that this mechanism cannot be the cause of the sun's equatorial acceleration.

  18. Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy

    Directory of Open Access Journals (Sweden)

    De Taboada Luis

    2009-06-01

    Full Text Available Abstract Background It has been hypothesized that reduced axonal transport contributes to the degeneration of neuronal processes in Parkinson's disease (PD. Mitochondria supply the adenosine triphosphate (ATP needed to support axonal transport and contribute to many other cellular functions essential for the survival of neuronal cells. Furthermore, mitochondria in PD tissues are metabolically and functionally compromised. To address this hypothesis, we measured the velocity of mitochondrial movement in human transmitochondrial cybrid "cytoplasmic hybrid" neuronal cells bearing mitochondrial DNA from patients with sporadic PD and disease-free age-matched volunteer controls (CNT. The absorption of low level, near-infrared laser light by components of the mitochondrial electron transport chain (mtETC enhances mitochondrial metabolism, stimulates oxidative phosphorylation and improves redox capacity. PD and CNT cybrid neuronal cells were exposed to near-infrared laser light to determine if the velocity of mitochondrial movement can be restored by low level light therapy (LLLT. Axonal transport of labeled mitochondria was documented by time lapse microscopy in dopaminergic PD and CNT cybrid neuronal cells before and after illumination with an 810 nm diode laser (50 mW/cm2 for 40 seconds. Oxygen utilization and assembly of mtETC complexes were also determined. Results The velocity of mitochondrial movement in PD cybrid neuronal cells (0.175 +/- 0.005 SEM was significantly reduced (p Conclusion The results from this study support our proposal that axonal transport is reduced in sporadic PD and that a single, brief treatment with near-infrared light can restore axonal transport to control levels. These results are the first demonstration that LLLT can increase axonal transport in model human dopaminergic neuronal cells and they suggest that LLLT could be developed as a novel treatment to improve neuronal function in patients with PD.

  19. a Study of Liquid - of Atomization Droplet Size Velocity and Temperature Distribution via Information Theory Spray Interaction with Ambient Air Motion.

    Science.gov (United States)

    Li, Xianguo

    Linear temporal instability analysis of a moving thin viscous liquid sheet of uniform thickness in an inviscid gas medium shows that surface tension always opposes, while surrounding gas and relative velocity between the sheet and gas favour the onset and development of instability. For gas Weber number smaller than the density ratio of gas to liquid, liquid viscosity enhances instability; If gas Weber number is slightly larger, aerodynamic and viscosity -induced instabilities interact with each other, displaying complicated effects of viscosity via Ohnesorge number; For much larger values of gas Weber numbers, aerodynamic instability dominates, liquid viscosity reduces disturbance growth rate and increases the dominant wavelength. Droplet probability distribution function (PDF) in sprays is formulated through information theory without resorting to the details of atomization processes. The derived analytical droplet size PDF is Nukiyama-Tanasawa type if conservation of mass is considered alone. If conservation of mass, momentum and energy is all taken into account, the joint droplet size and velocity PDF depends on Weber number, and compares favourably with measurements. Droplet velocity PDF is truncated Gaussian for any specific droplet size. Mean velocity approaches a constant value and velocity variance decreases as droplet size increases. Mean droplet diameters calculated agree well with observations. The computation indicates that atomization efficiency is very low, usually less than 1%. Droplet size, velocity and temperature PDF in sprays under combusting environment has also been derived. Effects of combustion on PDF occur mainly through the heat transferred into liquid sheet prior to its breakup. Experimental studies identify three modes of spray behaviours due to its interaction with various annular air flows, and show that bluff-body type of combustor has ability and easement to control aerodynamically spray angle, shape and droplet trajectories. It is

  20. Alternative ion-acoustic solitary waves in magnetized plasma consisting of warm adiabatic ions and non-thermal electrons having vortex-like velocity distribution: existence and stability

    Science.gov (United States)

    Das, Jayasree; Bandyopadhyay, Anup; Das, K. P.

    2007-12-01

    The solitary structures of the ion-acoustic waves have been considered in a plasma consisting of warm adiabatic ions and non-thermal electrons (due to the presence of fast energetic electrons) having a vortex-like velocity distribution function (due to the presence of trapped electrons), immersed in a uniform (space-independent) and static (time-independent) magnetic field. The nonlinear dynamics of ion-acoustic waves in such a plasma is governed by the Schamel's modified Korteweg-de Vries-Zakharov-Kuznetsov (S-ZK) equation. This equation admits solitary wave solutions having a profile sech4. When the coefficient of the nonlinear term of this equation vanishes, the vortex-like velocity distribution function of electrons simply becomes the non-thermal velocity distribution function of electrons and the nonlinear behaviour of the same ion-acoustic wave is described by a Korteweg-de Vries-Zakharov-Kuznetsov (KdV-ZK) equation. This equation admits solitary wave solutions having a profile sech2. A combined S-KdV-ZK equation more efficiently describes the nonlinear behaviour of an ion-acoustic wave when the vortex-like velocity distribution function of electrons approaches the non-thermal velocity distribution function of electrons, i.e. when the contribution of trapped electrons tends to zero. This combined S-KdV-ZK equation admits an alternative solitary wave solution having a profile different from either sech4 or sech2. The condition for the existence of this alternative solitary wave solution has been derived. It is found that this alternative solitary wave solution approaches the solitary wave solution (the sech2 profile) of the KdV-ZK equation when the contribution of trapped electrons tends to zero. The three-dimensional stability of these solitary waves propagating obliquely to the external uniform and static magnetic field has been investigated by the multiple-scale perturbation expansion method of Allen and Rowlands. The instability condition and the growth

  1. Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons

    International Nuclear Information System (INIS)

    To investigate the distribution of nerve growth factor (NGF) receptors on peripheral and central axons, [125I]NGF was injected into the sciatic nerve or spinal cord of adult rats. Accumulation of [125I]NGF in lumbar dorsal root ganglia was monitored by gamma emission counting and radioautography. [125I]NGF, injected endoneurially in small quantities, was taken into sensory axons by a saturable process and was transported retrogradely to their cell bodies at a maximal rate of 2.5 to 7.5 mm/hr. Because very little [125I]NGF reached peripheral terminals, the results were interpreted to indicate that receptors for NGF are present on nonterminal segments of sensory axons. The specificity and high affinity of NGF uptake were illustrated by observations that negligible amounts of gamma activity accumulated in lumbar dorsal root ganglia after comparable intraneural injection of [125I] cytochrome C or [125I]oxidized NGF. Similar techniques were used to demonstrate avid internalization and retrograde transport of [125I]NGF by intraspinal axons arising from dorsal root ganglia. Following injection of [125I]NGF into lumbar or cervical regions of the spinal cord, neuronal perikarya were clearly labeled in radioautographs of lumbar dorsal root ganglia. Sites for NGF uptake on primary sensory neurons in the adult rat are not restricted to peripheral axon terminals but are extensively distributed along both peripheral and central axons. Receptors on axons provide a mechanism whereby NGF supplied by glia could influence neuronal maintenance or axonal regeneration

  2. Demographics, Velocity Distributions, and Impact Type as Predictors of AIS 4+ Head Injuries in Motor Vehicle Crashes

    OpenAIRE

    Yoganandan, Narayan; Fitzharris, Michael; Pintar, Frank A.; Stemper, Brian D.; Rinaldi, James; Maiman, Dennis J.; Fildes, Brian N.

    2011-01-01

    The objective of the study was to determine differences between the United States-based NASS and CIREN and Australia-based ANCIS databases in occupant-, crash-, and vehicle-related parameters for AIS 4+ head injuries in motor vehicle crashes. Logistic regression analysis was performed to examine roles of the change in velocity (DV), crash type (frontal, far-side, nearside, rear impact), seatbelt use, and occupant position, gender, age, stature, and body mass in cranial traumas. Belted and unb...

  3. Analytical and numerical studies of approximate phase velocity matching based nonlinear S0 mode Lamb waves for the detection of evenly distributed microstructural changes

    Science.gov (United States)

    Wan, X.; Tse, P. W.; Xu, G. H.; Tao, T. F.; Zhang, Q.

    2016-04-01

    Most previous studies on nonlinear Lamb waves are conducted using mode pairs that satisfying strict phase velocity matching and non-zero power flux criteria. However, there are some limitations in existence. First, strict phase velocity matching is not existed in the whole frequency bandwidth; Second, excited center frequency is not always exactly equal to the true phase-velocity-matching frequency; Third, mode pairs are isolated and quite limited in number; Fourth, exciting a single desired primary mode is extremely difficult in practice and the received signal is quite difficult to process and interpret. And few attention has been paid to solving these shortcomings. In this paper, nonlinear S0 mode Lamb waves at low-frequency range satisfying approximate phase velocity matching is proposed for the purpose of overcoming these limitations. In analytical studies, the secondary amplitudes with the propagation distance considering the fundamental frequency, the maximum cumulative propagation distance (MCPD) with the fundamental frequency and the maximum linear cumulative propagation distance (MLCPD) using linear regression analysis are investigated. Based on analytical results, approximate phase velocity matching is quantitatively characterized as the relative phase velocity deviation less than a threshold value of 1%. Numerical studies are also conducted using tone burst as the excitation signal. The influences of center frequency and frequency bandwidth on the secondary amplitudes and MCPD are investigated. S1-S2 mode with the fundamental frequency at 1.8 MHz, the primary S0 mode at the center frequencies of 100 and 200 kHz are used respectively to calculate the ratios of nonlinear parameter of Al 6061-T6 to Al 7075-T651. The close agreement of the computed ratios to the actual value verifies the effectiveness of nonlinear S0 mode Lamb waves satisfying approximate phase velocity matching for characterizing the material nonlinearity. Moreover, the ratios derived from

  4. The Statistical Distribution of Turbulence Driven Velocity Extremes in the Atmosperic Boundary Layer cartwright/Longuet-Higgins Revised

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose

    " distribution, Cartwright and Longuet-Higgens [1] derived an asymptotic expression for the distribution of the largest excursion from the mean level during an arbitrary recurrence period. From its inception, this celebrated expression has been widely used in wind engineering (as well as in off-shore engineering...

  5. Evolution of The Proton Velocity Distribution due to Stochastic Heating in the Near-Sun Solar Wind

    CERN Document Server

    Klein, Kristopher G

    2016-01-01

    We investigate how the proton distribution function evolves when the protons undergo stochastic heating by strong, low-frequency, Alfv\\'en-wave turbulence under the assumption that $\\beta$ is small. We apply our analysis to protons undergoing stochastic heating in the supersonic fast solar wind and obtain proton distributions at heliocentric distances ranging from 4 to 30 solar radii. We find that the proton distribution develops non-Gaussian structure with a flat core and steep tail. For $r >5 \\ R_{\\rm S}$, the proton distribution is well approximated by a modified Moyal distribution. Comparisons with future measurements from \\emph{Solar Probe Plus} could be used to test whether stochastic heating is occurring in the solar-wind acceleration region.

  6. A theory of local and global processes which affect solar wind electrons. I - The origin of typical 1 AU velocity distribution functions - Steady state theory

    Science.gov (United States)

    Scudder, J. D.; Olbert, S.

    1979-01-01

    A kinetic theory for the velocity distribution of solar wind electrons which illustrates the global and local properties of the solar wind expansion is proposed. By means of the Boltzmann equation with the Krook collision operator accounting for Coulomb collisions, it is found that Coulomb collisions determine the population and shape of the electron distribution function in both the thermal and suprathermal energy regimes. For suprathermal electrons, the cumulative effects of Coulomb interactions are shown to take place on the scale of the heliosphere itself, whereas the Coulomb interactions of thermal electrons occur on a local scale near the point of observation (1 AU). The bifurcation of the electron distribution between thermal and suprathermal electrons is localized to the deep solar corona (1 to 10 solar radii).

  7. A theory of local and global processes which affect solar wind electrons. 1: The origin of typical 1 AU velocity distribution functions: Steady state theory

    Science.gov (United States)

    Scudder, J. D.

    1978-01-01

    A detailed first principle kinetic theory for electrons which is neither a classical fluid treatment nor an exospheric calculation is presented. This theory illustrates the global and local properties of the solar wind expansion that shape the observed features of the electron distribution function, such as its bifurcation, its skewness and the differential temperatures of the thermal and suprathermal subpopulations. Coulomb collisions are substantial mediators of the interplanetary electron velocity distribution function and they place a zone for a bifurcation of the electron distribution function deep in the corona. The local cause and effect precept which permeates the physics of denser media is modified for electrons in the solar wind. The local form of transport laws and equations of state which apply to collision dominated plasmas are replaced with global relations that explicitly depend on the relative position of the observer to the boundaries of the system.

  8. Velocity Memory

    OpenAIRE

    Makin, Alexis David James

    2011-01-01

    This Thesis, entitled ‘Velocity Memory’ is submitted to the University of Manchester by Alexis David James Makin (30/09/2010) for the degree of Doctor of Philosophy. It is known that primates are sensitive to the velocity of moving objects. We can also remember velocity information after moving objects disappear. This cognitive faculty has been investigated before, however, the literature on velocity memory to date has been fragmented. For example, velocity memory has been disparately descri...

  9. Numerical modeling of velocity distribution of coolant flow in fuel channel of a miniature neutron source reactor using navier-stokes equations

    International Nuclear Information System (INIS)

    One major requirement for safe operation of a nuclear reactor is adequate cooling system during normal and emergency conditions. Analysis of the heat and mass transfer, and coolant flow rate variables during operations of nuclear reactors are required for performing risk and hazard management to plan optimum reactor recovery strategies. The velocity distribution of coolant in the channel of the Ghana Research Reactor -1 (GHARR-1) is of major concern because when the velocity of the coolant is too fast it results in pool cooling. On the contrary when the flow rate is also slow, the possibility of boiling occurs and hence poor cooling. This is because the virtually stagnant coolant will take much of the heat generated from the core and would begin to boil which can also lead to core meltdown. These parameters can be determined through experimental setup and computer simulations using models based on the laws of fluid dynamics and thermodynamics. The research took into consideration a computer based model which used Navier Stokes equations of continuity, momentum and energy conservation to simulate flow patterns in the channels. The Navier Stokes equation was then expressed in algorithm using the Marker and Cell (MAC) finite different technique. The algorithm equations were then developed into matrix form (algebraic equations) by discretization. MATLAB has been used to code and solve the resulting finite different equations numerically to determine the velocity fields of coolant in the GHARR-1 reactor core channel. The velocity distribution in the Ghana research reactor (GHARR-1) was determined to be in the range of 0.9 m/s to 1.9 m/s. It is observed that the flow in the hottest channel was faster than the channel which were far from the center of the core and hence helped in removing much heat from the core of the reactor and ensuring reactor safety. (au)

  10. Genetics Home Reference: giant axonal neuropathy

    Science.gov (United States)

    ... in giant axonal neuropathy: new insights into disease mechanisms. Muscle Nerve. 2012 Aug;46(2):246-56. ... with a qualified healthcare professional . About Genetics Home Reference Site Map Contact Us Selection Criteria for Links ...

  11. Population alignment collisional radiative model for helium-like carbon. Polarization of emission lines and anisotropy of the electron velocity distribution function in plasmas

    International Nuclear Information System (INIS)

    The polarization of emission lines from a plasma carries information about the anisotropic velocity distribution of electrons in the plasma, and thus polarization spectroscopy can give information that is inaccessible by other methods. We have developed a comprehensive population-alignment collisional-radiative (PACR) model code for helium-like carbon CV ions. This code is intended to correlate quantitatively the observed polarization of emission lines from the ions in a plasma with the anisotropy of the electron velocity distribution function. Specifically, the longitudinal alignment of CV triplet emission lines for the 1s2s3S1 - 1s2p3P1,2) transitions are studied by this PACR model. The predominant process which produces alignment in the 1s2p3P1,2 levels is the alignment production from the ground state, 1s21S1 and from the metastable level, 1s2s3S1. The alignment-production fluxes from these levels are in the opposite directions in the temperature range of practical interest, depending on the electron density ne. When ne > 1016 m-3, the alignment-production flux from the metastable level is larger than that from the ground state. An anisotropic electron velocity distribution function that has higher values in the axial (toroidal) direction than in the radial (poloidal) direction produces negative longitudinal alignment of the emission lines, i.e., higher intensity of the linear polarized component in the radial direction than that in the axial direction. (author)

  12. Direct detection of neutral metal atoms in electron-stimulated desorption: Al from CH3O/Al(111) - velocity distribution and absolute yield

    International Nuclear Information System (INIS)

    Electron-stimulated desorption of neutral aluminum from the system CH3O/Al(111) has been directly monitored via quasiresonant photoionization with 193 nm excimer laser light and confirmed by two-step resonant ionization, utilizing the Al 3d 2D manifold. Velocity distribution measurements for the neutral Al peak at ∼ 800 m/s for 1 keV incident electron energy. An absolute yield of 3.2 x 10-6 Al atoms/electron was determined by comparison with sputtering measurements in the same apparatus. This is the first observation of electron-stimulated metal desorption from adsorbate-covered metallic surfaces

  13. Modelling of Distribution of Velocities and Pressures in the Vortex Flow in the Counter-Flowmeter of Heating System

    Directory of Open Access Journals (Sweden)

    Kobelev N.S.

    2010-04-01

    Full Text Available Problem statement. The absence of possibility of registration of small heat-carrier discharges is revealed on the basis of the analysis of well-known methods of heat supply control. Results and conclusions. The vortex type measuring device is suggested for which the mathematical model describing interaction of velocity and pressure fields applied to specific movement conditions of two-component medium (a liquid and solid particles of rust and scale is developed. Mathematical modeling of the force action of the heat carrier made it possible to consider the vortex core as a solid body acting on recording element of the flowmeter, which provides for more lower sensitivity level, for example, of the counter-flowmeter of the heating system.

  14. Measurement of a 2D fast-ion velocity distribution function by tomographic inversion of fast-ion D-alpha spectra

    CERN Document Server

    Salewski, Mirko; Jacobsen, Asger Schou; Garcıa-Munoz, Manuel; Heidbrink, Bill; Korsholm, Soren Bang; Leipold, Frank; Madsen, Jens; Moseev, Dmitry; Nielsen, Stefan Kragh; Rasmussen, Jesper; Stejner, Morten; Tardini, Giovanni; Weiland, Markus

    2015-01-01

    We present the first measurement of a local fast-ion 2D velocity distribution function $f(v_\\parallel, v_\\perp)$. To this end, we heated a plasma in ASDEX Upgrade by neutral beam injection and measured spectra of fast-ion D-alpha (FIDA) light from the plasma center in three views simultaneously. The measured spectra agree very well with synthetic spectra calculated from a TRANSP/NUBEAM simulation. Based on the measured FIDA spectra alone, we infer $f(v_\\parallel, v_\\perp)$ by tomographic inversion. Salient features of our measurement of $f(v_\\parallel, v_\\perp)$ agree reasonably well with the simulation: the measured as well as the simulated $f(v_\\parallel, v_\\perp)$ are lopsided towards negative velocities parallel to the magnetic field, and they have similar shapes. Further, the peaks in the simulation of $f(v_\\parallel, v_\\perp)$ at full and half injection energies of the neutral beam also appear in the measurement at similar velocity-space locations. We expect that we can measure spectra in up to seven vi...

  15. Angular and velocity distributions of HD molecules produced by the H/sub 2/--D/sub 2/ exchange reaction on the stepped Pt(557) surface

    Energy Technology Data Exchange (ETDEWEB)

    Lin, T.H.; Somorjai, G.A.

    1984-07-15

    The H/sub 2/--D/sub 2/ exchange reaction on Pt(557) crystal surface was investigated using a molecular beam surface scattering technique. The angular and velocity distributions of the HD product were measured at various crystal temperatures (500--1170 K). It was found that the exchange reaction occurred via interactions of adsorbed H and D atoms (Langmuir--Hinshelwood mechanism). Although the HD that is produced desorbs with a cos/sup 2/ theta angular distribution, its translational energy corresponds to a temperature slightly colder than that of the substrate with the mean energy of the desorbing molecules depending on the desorption angle. As the desorbing angle increases away from the surface normal, the mean translational energy decreases. The exchange reactivity was found to be incident azimuthal angle dependent while the translational energy of the product HD is independent of the azimuthal angle of detection.

  16. Velocity and angular distributions of cations produced upon laser desorption of C{sub 60} and C{sub 60}O{sub x} (x = 2-4)

    Energy Technology Data Exchange (ETDEWEB)

    Beck, R.D.; Weis, P.; Rockenberger, J.; Kappes, M.M. [Universitaet Karlsruhe (Germany)

    1995-03-23

    The mechanism of UV laser desorption/ionization of C{sub 60} and C{sub 60}O{sub x} (x = 2-4) has been studied by measuring the angle and arrival time distribution for positive ions generated upon laser irradiation of microcrystalline targets. Observations include evidence for desorption `jet` formation as well as for on-beam axis enrichment of coalescence products. These measurements imply that internal and kinetic energy of promptly desorbing material are correlated and suggest that coalescence products such as C{sub 118}{sup +} are generated within the material ablated by one laser pulse rather than from previous photopolymerization. The data are contrasted to laser desorption measurements of NaI/CsI mixed targets for which near effusive ion velocity distributions are observed. 30 refs., 11 figs.

  17. Effect of the borax mass and pre-spray medium temperature on droplet size and velocity vector distributions of intermittently sprayed starchy solutions.

    Science.gov (United States)

    Naz, Muhammad Yasin; Sulaiman, Shaharin Anwar; Ariwahjoedi, Bambang

    2015-02-01

    Spray coating technology has demonstrated great potential in the slow release fertilizers industry. The better understanding of the key spray parameters benefits both the environment and low cost coating processes. The use of starch based materials to coat the slow release fertilizers is a new development. However, the hydraulic spray jet breakup of the non-Newtonian starchy solutions is a complex phenomenon and very little known. The aim of this research was to study the axial and radial distributions of the Sauter Mean Diameter (SMD) and velocity vectors in pulsing spray patterns of native and modified tapioca starch solutions. To meet the objective, high speed imaging and Phase Doppler Anemometry (PDA) techniques were employed to characterize the four compositions of the starch-urea-borax complex namely S0, S1, S2 and S3. The unheated solutions exhibited very high viscosities ranging from 2035 to 3030 cP. No jet breakup was seen at any stage of the nozzle operation at an injection pressure of 1-5 bar. However, at 80 °C temperature and 5 bar pressure, the viscosity was reduced to 455 to 638 cP and dense spray patterns emerged from the nozzle obscuring the PDA signals. The axial size distribution revealed a significant decrease in SMD along the spray centreline. The smallest axial SMD (51 to 79 μm) was noticed in S0 spray followed by S1, S2 and S3. Unlikely, the radial SMD in S0 spray did not vary significantly at any stage of the spray injection. This trend was attributed to the continuous growth of the surface wave instabilities on the native starch sheet. However, SMD obtained with S1, S2 and S3 varied appreciably along the radial direction. The mean velocity vector profiles followed the non-Gaussian distribution. The constant vector distributions were seen in the near nozzle regions, where the spray was in the phase of development. In far regions, the velocity vectors were poly-dispersed and a series of ups and downs were seen in the respective radial

  18. Escape Velocity

    OpenAIRE

    Nikola Vlacic

    2010-01-01

    In this project, we investigated if it is feasible for a single staged rocket with constant thrust to attain escape velocity. We derived an equation for the velocity and position of a single staged rocket that launches vertically. From this equation, we determined if an ideal model of a rocket is able to reach escape velocity.

  19. Rotation Curve and Mass Distribution in the Galaxy from the Velocities of Objects at Distances up to 200 kpc

    CERN Document Server

    Bajkova, A T

    2016-01-01

    Three three-component (bulge, disk, halo) model Galactic gravitational potentials differing by the expression for the dark matter halo are considered. The central (bulge) and disk components are described by the Miyamoto-Nagai expressions. The Allen-Santill'an (I), Wilkinson-Evans (II), and Navarro-Frenk-White (III) models are used to describe the halo. A set of present-day observational data in the range of Galactocentric distances R from 0 to 200 kpc is used to refine the parameters of these models. The model rotation curves have been fitted to the observed velocities by taking into account the constraints on the local matter density \\rho_\\odotand the force K_{z=1.1} acting perpendicularly to the Galactic plane. The Galactic mass within a sphere of radius 50 kpc, M_G (R<=50 kpc)=(0.41+/-0.12)x10^12 M_\\odot, is shown to satisfy all three models. The differences between the models become increasingly significant with increasing radius R. In model I, the Galactic mass within a sphere of radius 200 kpc turns...

  20. Modulational instability of ion-acoustic waves in plasma with a q-nonextensive nonthermal electron velocity distribution

    International Nuclear Information System (INIS)

    Modulation instability of ion-acoustic waves (IAWs) is investigated in a collisionless unmagnetized one dimensional plasma, containing positive ions and electrons following the mixed nonextensive nonthermal distribution [Tribeche et al., Phys. Rev. E 85, 037401 (2012)]. Using the reductive perturbation technique, a nonlinear Schrödinger equation which governs the modulation instability of the IAWs is obtained. Valid range of plasma parameters has been fixed and their effects on the modulational instability discussed in detail. We find that the plasma supports both bright and dark solutions. The valid domain for the wave number k where instabilities set in varies with both nonextensive parameter q as well as non thermal parameter α. Moreover, the analysis is extended for the rational solutions of IAWs in the instability regime. Present study is useful for the understanding of IAWs in the region where such mixed distribution may exist

  1. Modulational instability of electron-acoustic waves in a plasma with a q-nonextensive electron velocity distribution

    Energy Technology Data Exchange (ETDEWEB)

    Bains, Amandeep Singh, E-mail: bainsphysics@yahoo.co.i [Department of Physics, Guru Nanak Dev University, Amritsar 143005 (India); Tribeche, Mouloud [Plasma Physics Group (PPG), Theoretical Physics Laboratory (TPL), Faculty of Sciences-Physics, University of Bab-Ezzouar, U.S.T.H.B., B.P. 32, El Alia, Algiers 16111 (Algeria); Gill, Tarsem Singh [Department of Physics, Guru Nanak Dev University, Amritsar 143005 (India)

    2011-05-16

    The amplitude modulation of electron-acoustic waves (EAWs) propagating in space plasmas whose constituents are inertial cold electrons, hot nonextensive q-distributed electrons, and stationary ions is presented theoretically. The nonlinear Schroedinger equation (NLSE) which governs the modulational instability of the EAWs is obtained using reductive perturbation method (RPM). The presence of the hot nonextensive q-distributed electrons is shown to influence the modulational instability of the waves. Further, the nondimensional parameter {alpha}=n{sub e0}/n{sub c0}, which is the equilibrium density ratio of the hot to cold electron component, is shown to play a vital role in the formation of both bright and dark solitons. - Highlights: Nonlinear Schroedinger equation is derived for EAW with nonextensive electrons. Both dark and bright excitations are formed. The critical wave number increase with increase in the nonextensive parameter.

  2. Transport and Aggregation of Nanoparticles in Packed Beds: Effects of Pore Velocity and Initially-Fed Particle Size on Transient Particle Size Distributions

    Science.gov (United States)

    Pham, Ngoc; Papavassiliou, Dimitrios

    2015-11-01

    Aggregation of colloidal particles in flow through porous media has received careful consideration, as it reduces particle breakthrough due to pore clogging and sedimentation. Additionally, in unstable colloidal systems, deposition of colloidal aggregates on the pore surfaces can create sub-surfaces for further colloidal attachment. This phenomenon is known as ripening effect. In this study, transient particle size distributions of nano-particle systems, propagating in a bed packed with spheres are numerically investigated. In our simulation, only pair interactions are considered, and the aggregation rate is varied with the relative position of two particles in a pair. The packed bed consists of spheres of known size, randomly packed in a simulation box. To generate the velocity field of water inside the porous medium, the lattice Boltzmann method (LBM) is used. In conjunction with that, the trajectories of thousands of massless particles moving with the flow under convection and diffusion are recorded employing a Lagrangian framework. While pore clogging is neglected, we draw attention to the change of the distribution of particle size under different pore velocities and different initially-fed particle sizes.

  3. Dendrite-derived supernumerary axons on adult axotomized motor neurons possess proteins that are essential for the initiation and propagation of action potentials and synaptic vesicle release

    DEFF Research Database (Denmark)

    Meehan, Claire Francesca; MacDermid, Victoria E; Montague, Steven J;

    2011-01-01

    . This study extends this definition to determine whether, more importantly, these processes possess the prerequisite molecular machinery to function as axons. Using a combination of intracellular labeling and immunohistochemistry, we demonstrate that the distribution of voltage-gated sodium channels on...... from the tips of distal dendrites represent a rearrangement of neuronal polarity whereby axotomized neurons can develop additional functional axons in vivo....

  4. About measuring velocity dispersions

    Science.gov (United States)

    Fellhauer, M.

    A lot of our knowledge about the dynamics and total masses of pressure dominated stellar systems relies on measuring the internal velocity disper- sion of the system. We assume virial equilibrium and that we are able to measure only the bound stars of the system without any contamination. This article shows how likely it is to measure the correct velocity dispersion in reality. It will show that as long as we have small samples of velocity mea- surements the distribution of possible outcomes can be very large and as soon as we have a source of error the velocity dispersion can wrong by several standard deviations especially in large samples.

  5. Demographics, Velocity Distributions, and Impact Type as Predictors of AIS 4+ Head Injuries in Motor Vehicle Crashes.

    Science.gov (United States)

    Yoganandan, Narayan; Fitzharris, Michael; Pintar, Frank A; Stemper, Brian D; Rinaldi, James; Maiman, Dennis J; Fildes, Brian N

    2011-01-01

    The objective of the study was to determine differences between the United States-based NASS and CIREN and Australia-based ANCIS databases in occupant-, crash-, and vehicle-related parameters for AIS 4+ head injuries in motor vehicle crashes. Logistic regression analysis was performed to examine roles of the change in velocity (DV), crash type (frontal, far-side, nearside, rear impact), seatbelt use, and occupant position, gender, age, stature, and body mass in cranial traumas. Belted and unbelted non-ejected occupant (age >16 years) data from 1997-2006 were used for the NASS and CIREN datasets, and 2000-2010 for ANCIS. Vehicle model year, and occupant position and demographics including body mass index (BMI) data were obtained. Injuries were coded using AIS 1990-1998 update. Similarities were apparent across all databases: mean demographics were close to the mid-size anthropometry, mean BMI was in the normal to overweight range, and representations of extreme variations were uncommon. Side impacts contributed to over one-half of the ensemble, implying susceptibility to head trauma in this mode. Odds of sustaining head injury increased by 4% per unit increase in DV (OR: 1.04, 95% CI: 1.03-1.04, poccupants (OR: 0.48, 95% CI: 0.37-0.61, poccupant-related outcomes from the two continents indicate a worldwide need to revise the translation acceleration-based head injury criterion to include the angular component in an appropriate format for improved injury assessment and mitigation. PMID:22105402

  6. Determination of concentration distribution and velocity of a catalyst in a model of a fluidized bed reactor using nuclear techniques

    International Nuclear Information System (INIS)

    A simplified model of a cracking unit was construct. The gaseous phase consisted of air, the solid phase (zeolite catalyst cracking) and both the phases circulate at the ambiente temperature in the steady state with 500 g of catalyst and air flow of 1600 1/h. Measurements for the circulation time of the solid phase (catalyst), concentration and radial distribution of catalyst have been carried out. The reduced experimental model of the cracking reactor (FCC) was used and radioctive tracer and attenuation of γ-radiation techniques were employed. (E.G.)

  7. Protein phosphorylation: Localization in regenerating optic axons

    International Nuclear Information System (INIS)

    A number of axonal proteins display changes in phosphorylation during goldfish optic nerve regeneration. (1) To determine whether the phosphorylation of these proteins was closely linked to their synthesis in the retinal ganglion cell body, cycloheximide was injected intraocularly into goldfish whose optic nerves had been regenerating for 3 weeks. Cycloheximide reduced the incorporation of [3H]proline and 32P orthophosphate into total nerve protein by 84% and 46%, respectively. Of the 20 individual proteins examined, 17 contained less than 15% of the [3H]proline label measured in corresponding controls, whereas 18 proteins contained 50% or more of the 32P label, suggesting that phosphorylation was largely independent of synthesis. (2) To determine whether the proteins were phosphorylated in the ganglion cell axons, axonal transport of proteins was blocked by intraocular injection of vincristine. Vincristine reduced [3H]proline labeling of total protein by 88% and 32P labeling by 49%. Among the individual proteins [3H]proline labeling was reduced by 90% or more in 18 cases but 32P labeling was reduced only by 50% or less. (3) When 32P was injected into the cranial cavity near the ends of the optic axons, all of the phosphoproteins were labeled more intensely in the optic tract than in the optic nerve. These results suggest that most of the major phosphoproteins that undergo changes in phosphorylation in the course of regeneration are phosphorylated in the optic axons

  8. How Schwann Cells Sort Axons: New Concepts.

    Science.gov (United States)

    Feltri, M Laura; Poitelon, Yannick; Previtali, Stefano Carlo

    2016-06-01

    Peripheral nerves contain large myelinated and small unmyelinated (Remak) fibers that perform different functions. The choice to myelinate or not is dictated to Schwann cells by the axon itself, based on the amount of neuregulin I-type III exposed on its membrane. Peripheral axons are more important in determining the final myelination fate than central axons, and the implications for this difference in Schwann cells and oligodendrocytes are discussed. Interestingly, this choice is reversible during pathology, accounting for the remarkable plasticity of Schwann cells, and contributing to the regenerative potential of the peripheral nervous system. Radial sorting is the process by which Schwann cells choose larger axons to myelinate during development. This crucial morphogenetic step is a prerequisite for myelination and for differentiation of Remak fibers, and is arrested in human diseases due to mutations in genes coding for extracellular matrix and linkage molecules. In this review we will summarize progresses made in the last years by a flurry of reverse genetic experiments in mice and fish. This work revealed novel molecules that control radial sorting, and contributed unexpected ideas to our understanding of the cellular and molecular mechanisms that control radial sorting of axons. PMID:25686621

  9. Calpain activity promotes the sealing of severed giant axons

    OpenAIRE

    Godell, Christopher M.; Smyers, Mark E.; Eddleman, Christopher S.; Ballinger, Martis L.; Fishman, Harvey M.; Bittner, George D.

    1997-01-01

    A barrier (seal) must form at the cut ends of a severed axon if a neuron is to survive and eventually regenerate. Following severance of crayfish medial giant axons in physiological saline, vesicles accumulate at the cut end and form a barrier (seal) to ion and dye diffusion. In contrast, squid giant axons do not seal, even though injury-induced vesicles form after axonal transection and accumulate at cut axonal ends. Neither axon seals in Ca2+-free salines. The addition of calpain to the bat...

  10. 横向双极电除尘器的速度分布特征%Characteristics of the Velocity Distribution in Bipolar Transverse Plate ESP

    Institute of Scientific and Technical Information of China (English)

    向晓东; 聂衍韬; 丁娣

    2015-01-01

    为了提高现有电除尘器的除尘效果,提出一种横向双极电除尘器。用计算流体动力学(CFD )软件的模拟结果表明,当横向双极电除尘器入口风速为1 m/s时,在距横向双极电除尘器极板迎风面40 mm范围内,平均速度小于0.7m/s,在距极板背风面40mm范围内,平均速度小于0.3m/s。不同的异极距的流速模拟对比发现,异极距在150~250 mm之间时,横向双极电除尘器极板附近的平均流速较小,远远小于普通电除尘器极板附近的风速,这将非常有利于横向双极电除尘器获得更高的除尘效率。理论、模拟与实验的结果证明,极板附近的速度分布规律呈凹形。%In order to improve the particle collection efficiency of the electrostatic precipitator (ESP) ,a bipolar transverse-plate ESP is proposed .The results obtained by the CFD software show that ,when the inlet velocity of the bipolar trans-verse plate ESP is 1 m/s ,the average velocities of windward side and leeward side are less than 0 .7 m/s and 0 .3 m/s re-spectively in the range of 40 mm from the collection electrode plate .It is also found that the average velocities are lower when the electrode distance changes between 150~250 mm .The velocity near the collection electrode plate of the bipolar transverse plate ESP is far lower than that of the ordinary ESP .Therefore ,the bipolar charged transverse-plate ESP can get higher efficiency for fine particulate collection .The theories ,simulations and experiments indicate that the velocity distribu-tion near the plates shows concave .

  11. Propagation of Electron Acoustic Soliton, Periodic and Shock Waves in Dissipative Plasma with a q-Nonextensive Electron Velocity Distribution

    Science.gov (United States)

    A. M., El-Hanbaly; E. K., El-Shewy; Elgarayhi, A.; A. I., Kassem

    2015-11-01

    The nonlinear properties of small amplitude electron-acoustic (EA) solitary and shock waves in a homogeneous system of unmagnetized collisionless plasma with nonextensive distribution for hot electrons have been investigated. A reductive perturbation method used to obtain the Kadomstev-Petviashvili-Burgers equation. Bifurcation analysis has been discussed for non-dissipative system in the absence of Burgers term and reveals different classes of the traveling wave solutions. The obtained solutions are related to periodic and soliton waves and their behavior are shown graphically. In the presence of the Burgers term, the EXP-function method is used to solve the Kadomstev-Petviashvili-Burgers equation and the obtained solution is related to shock wave. The obtained results may be helpful in better conception of waves propagation in various space plasma environments as well as in inertial confinement fusion laboratory plasmas.

  12. Microfluidic device for unidirectional axon growth

    Science.gov (United States)

    Malishev, E.; Pimashkin, A.; Gladkov, A.; Pigareva, Y.; Bukatin, A.; Kazantsev, V.; Mukhina, I.; Dubina, M.

    2015-11-01

    In order to better understand the communication and connectivity development of neuron networks, we designed microfluidic devices with several chambers for growing dissociated neuronal cultures from mice fetal hippocampus (E18). The chambers were connected with microchannels providing unidirectional axonal growth between “Source” and “Target” neural sub-networks. Experiments were performed in a hippocampal cultures plated in a poly-dimethylsiloxane (PDMS) microfluidic chip, aligned with a 60 microelectrode array (MEA). Axonal growth through microchannels was observed with brightfield, phase-contrast and fluorescence microscopy, and after 7 days in vitro electrical activity was recorded. Visual inspection and spike propagation analysis showed the predominant axonal growth in microchannels in a direction from “Source” to “Target”.

  13. Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon

    Directory of Open Access Journals (Sweden)

    Michal Segal

    2012-01-01

    Bidirectional transport is a key issue in cellular biology. It requires coordination between microtubule-associated molecular motors that work in opposing directions. The major retrograde and anterograde motors involved in bidirectional transport are cytoplasmic dynein and conventional kinesin, respectively. It is clear that failures in molecular motor activity bear severe consequences, especially in the nervous system. Neuronal migration may be impaired during brain development, and impaired molecular motor activity in the adult is one of the hallmarks of neurodegenerative diseases leading to neuronal cell death. The mechanisms that regulate or coordinate kinesin and dynein activity to generate bidirectional transport of the same cargo are of utmost importance. We examined how Ndel1, a cytoplasmic dynein binding protein, may regulate non-vesicular bidirectional transport. Soluble Ndel1 protein, Ndel1-derived peptides or control proteins were mixed with fluorescent beads, injected into the squid giant axon, and the bead movements were recorded using time-lapse microscopy. Automated tracking allowed for extraction and unbiased analysis of a large data set. Beads moved in both directions with a clear bias to the anterograde direction. Velocities were distributed over a broad range and were typically slower than those associated with fast vesicle transport. Ironically, the main effect of Ndel1 and its derived peptides was an enhancement of anterograde motion. We propose that they may function primarily by inhibition of dynein-dependent resistance, which suggests that both dynein and kinesin motors may remain engaged with microtubules during bidirectional transport.

  14. Diverse modes of axon elaboration in the developing neocortex.

    Directory of Open Access Journals (Sweden)

    2005-08-01

    Full Text Available The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice over the first 3 wk of postnatal development. This period spans the elaboration of thalamocortical (TC and Cajal-Retzius (CR axons and cortical synaptogenesis. Layer 1 collaterals of TC and CR axons were imaged repeatedly over time scales ranging from minutes up to days, and their growth and pruning were analyzed. The structure and dynamics of TC and CR axons differed profoundly. Branches of TC axons terminated in small, bulbous growth cones, while CR axon branch tips had large growth cones with numerous long filopodia. TC axons grew rapidly in straight paths, with frequent interstitial branch additions, while CR axons grew more slowly along tortuous paths. For both types of axon, new branches appeared at interstitial sites along the axon shaft and did not involve growth cone splitting. Pruning occurred via retraction of small axon branches (tens of microns, at both CR and TC axons or degeneration of large portions of the arbor (hundreds of microns, for TC axons only. The balance between growth and retraction favored overall growth, but only by a slight margin. Given the identical layer 1 territory upon which CR and TC axons grow, the differences in their structure and dynamics likely reflect distinct intrinsic growth programs for axons of long projection neurons versus local interneurons.

  15. Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity.

    Directory of Open Access Journals (Sweden)

    A Heckel

    Full Text Available To investigate the potential of diffusion tensor imaging (DTI parameters as in-vivo biomarkers of axon and myelin sheath integrity of the median nerve in the carpal tunnel as validated by correlation with electrophysiology.MRI examinations at 3T including DTI were conducted on wrists in 30 healthy subjects. After manual segmentation of the median nerve quantitative analysis of fractional anisotropy (FA as well as axial, radial and mean diffusivity (AD, RD, and MD was carried out. Pairwise Pearson correlations with electrophysiological parameters comprising sensory nerve action potential (SNAP and compound muscle action potential (CMAP as markers of axon integrity, and distal motor latency (dml and sensory nerve conduction velocity (sNCV as markers of myelin sheath integrity were computed. The significance criterion was set at P=0.05, Bonferroni corrected for multiple comparisons.DTI parameters showed a distinct proximal-to-distal profile with FA, MD, and RD extrema coinciding in the center of the carpal tunnel. AD correlated with CMAP (r=0.50, p=0.04, Bonf. corr. but not with markers of myelin sheath integrity. RD correlated with sNCV (r=-0.53, p=0.02, Bonf. corr. but not with markers of axon integrity. FA correlated with dml (r=-0.63, p=0.002, Bonf. corr. and sNCV (r=0.68, p=0.001, Bonf. corr. but not with markers of axon integrity.AD reflects axon integrity, while RD (and FA reflect myelin sheath integrity as validated by correlation with electrophysiology. DTI parameters consistently indicate a slight decrease of structural integrity in the carpal tunnel as a physiological site of median nerve entrapment. DTI is particularly sensitive, since these findings are observed in healthy participants. Our results encourage future studies to evaluate the potential of DTI in differentiating axon from myelin sheath injury in patients with manifest peripheral neuropathies.

  16. Automated Axon Counting in Rodent Optic Nerve Sections with AxonJ

    Science.gov (United States)

    Zarei, Kasra; Scheetz, Todd E.; Christopher, Mark; Miller, Kathy; Hedberg-Buenz, Adam; Tandon, Anamika; Anderson, Michael G.; Fingert, John H.; Abràmoff, Michael David

    2016-01-01

    We have developed a publicly available tool, AxonJ, which quantifies the axons in optic nerve sections of rodents stained with paraphenylenediamine (PPD). In this study, we compare AxonJ’s performance to human experts on 100x and 40x images of optic nerve sections obtained from multiple strains of mice, including mice with defects relevant to glaucoma. AxonJ produced reliable axon counts with high sensitivity of 0.959 and high precision of 0.907, high repeatability of 0.95 when compared to a gold-standard of manual assessments and high correlation of 0.882 to the glaucoma damage staging of a previously published dataset. AxonJ allows analyses that are quantitative, consistent, fully-automated, parameter-free, and rapid on whole optic nerve sections at 40x. As a freely available ImageJ plugin that requires no highly specialized equipment to utilize, AxonJ represents a powerful new community resource augmenting studies of the optic nerve using mice. PMID:27226405

  17. Determination of the electron velocity distribution from the soft and hard x-ray emission during lower-hybrid current drive on PLT

    International Nuclear Information System (INIS)

    During lower-hybrid heating in low-density-tokamak discharges, a nonMaxwellian tail of high-energy electrons is formed. This tail carries the plasma current. Utilizing the fact that relativistic electrons emit bremsstrahlung predominantly in the forward direction, we investigate the shape of the electron distribution by measuring the dependence of the x-ray emission on the angle between the magnetic field and the line of sight. The experimental data indicate that the distribution function is predominantly peaked in the forward direction, although a small fraction of the electrons is in the backward cone. The energy dependence of the x-ray spectra is consistent with that of a velocity distribution which has a plateau extending out to several hundred kiloelectron volts. Radial profiles show that the hot electrons are located in the central plasma region and form a high-conductivity plasma with the current profile frozen in. The slope of the spectrum depends on the rf power and on the phasing of the waveguide grill, but not on the externally applied plasma voltage. Relaxation oscillations occur shortly after switching the rf off. They also appear during the rf for low rf power and at the high-density limit of the lower-hybrid current drive. The x-ray spectra confirm that parallel energy is transferred to perpendicular energy during the instability, suggesting an instability due to the anomalous Doppler effect

  18. Measurement of resuspended aerosol in the Chernobyl area. Pt. III. Size distribution and dry deposition velocity of radioactive particles during anthropogenic enhanced resuspension

    International Nuclear Information System (INIS)

    During anthropogenic activities, such as agricultural soil management and traffic on unpaved roads, size distribution measurements were performed of atmospheric particulate radionuclides at a site in the Chernobyl 30-km exclusion zone. Analysis of cascade impactor measurements showed an increase of the total atmospheric radioactivity. In the cases of harrowing by a tractor and traffic on unpaved roads, a common shape of the size distribution was found with two maxima, the first in the 2-4 μm range, the second in the 12-20 μm range. The size distributions were compared to measurements during wind-driven resuspension. Particle number concentration measurements with an Aerodynamic Particle Sizer showed a dynamic dependence of the particle concentration in different size ranges on anthropogenic action. The increase of the mean concentration was for the large particles more than one order of magnitude higher than for fine particles during anthropogenic enhanced resuspension. From the measurement of the mass concentration, the radioactive loading could be estimated. An enrichment of radionuclides on resuspended particles (compared to soil particles) was found, with the highest enrichment for large particles. Micrometeorological considerations showed that large particles may frequently be subject to medium range transport. The dry deposition velocity was measured; the mean value of 0.026 m s-1±0.016 m s-1 is typical for 6-9 μm diameter particles. (orig.)

  19. MSC p43 required for axonal development in motor neurons

    Science.gov (United States)

    Zhu, Xiaodong; Liu, Yang; Yin, Yanqing; Shao, Aiyun; Zhang, Bo; Kim, Sunghoon; Zhou, Jiawei

    2009-01-01

    Neuron connectivity and correct neural function largely depend on axonal integrity. Neurofilaments (NFs) constitute the main cytoskeletal network maintaining the structural integrity of neurons and exhibit dynamic changes during axonal and dendritic growth. However, the mechanisms underlying axonal development and maintenance remain poorly understood. Here, we identify that multisynthetase complex p43 (MSC p43) is essential for NF assembly and axon maintenance. The MSC p43 protein was predominantly expressed in central neurons and interacted with NF light subunit in vivo. Mice lacking MSC p43 exhibited axon degeneration in motor neurons, defective neuromuscular junctions, muscular atrophy, and motor dysfunction. Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs. Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases. PMID:19717447

  20. Chick PTPσ regulates the targeting of retinal axons within the optic tectum

    OpenAIRE

    Rashid-Doubell, F.; McKinnell, I.; Aricescu, A R; Sajnani, G.; Stoker, A.

    2002-01-01

    Chick PTP (cPTP), also known as CRYP, is a receptor-like protein tyrosine phosphatase found on axons and growth cones. Putative ligands for cPTP are distributed within basement membranes and on glial end feet of the retina, optic nerve, and optic tectum, suggesting that cPTP signaling is occurring along the whole retinotectal pathway. We have shown previously that cPTP plays a role in supporting the retinal phase of axon outgrowth. Here we have now addressed the role of cPTP within retinal...

  1. Solar Wind Halo Formation by the Scattering of the Strahl via Direct Cluster/PEACE Observations of the 3D Velocity Distribution Function

    Science.gov (United States)

    Figueroa-Vinas, Adolfo; Gurgiolo, Chris A.; Nieves-Chinchilla, Teresa; Goldstein, Melvyn L.

    2010-01-01

    It has been suggested by a number of authors that the solar wind electron halo can be formed by the scattering of the strahl. On frequent occasions we have observed in electron angular skymaps (Phi/Theta-plots) of the electron 3D velocity distribution functions) a bursty-filament of particles connecting the strahl to the solar wind core-halo. These are seen over a very limited energy range. When the magnetic field is well off the nominal solar wind flow direction such filaments are inconsistent with any local forces and are probably the result of strong scattering. Furthermore, observations indicates that the strahl component is frequently and significantly anisotropic (Tper/Tpal approx.2). This provides a possible free energy source for the excitation of whistler waves as a possible scattering mechanism. The empirical observational evidence between the halo and the strahl suggests that the strahl population may be, at least in part, the source of the halo component.

  2. Discriminant analysis for the prediction of sand mass distribution in an urban stormwater holding pond using simulated depth average flow velocity data.

    Science.gov (United States)

    Dominic, Jeremy Andy; Aris, Ahmad Zaharin; Sulaiman, Wan Nor Azmin; Tahir, Wan Zakaria Wan Md

    2016-03-01

    The approach of this paper is to predict the sand mass distribution in an urban stormwater holding pond at the Stormwater Management And Road Tunnel (SMART) Control Centre, Malaysia, using simulated depth average floodwater velocity diverted into the holding during storm events. Discriminant analysis (DA) was applied to derive the classification function to spatially distinguish areas of relatively high and low sand mass compositions based on the simulated water velocity variations at corresponding locations of gravimetrically measured sand mass composition of surface sediment samples. Three inflow parameter values, 16, 40 and 80 m(3) s(-1), representing diverted floodwater discharge for three storm event conditions were fixed as input parameters of the hydrodynamic model. The sand (grain size > 0.063 mm) mass composition of the surface sediment measured at 29 sampling locations ranges from 3.7 to 45.5 %. The sampling locations of the surface sediment were spatially clustered into two groups based on the sand mass composition. The sand mass composition of group 1 is relatively lower (3.69 to 12.20 %) compared to group 2 (16.90 to 45.55 %). Two Fisher's linear discriminant functions, F 1 and F 2, were generated to predict areas; both consist of relatively higher and lower sand mass compositions based on the relationship between the simulated flow velocity and the measured surface sand composition at corresponding sampling locations. F 1 = -9.405 + 4232.119 × A - 1795.805 × B + 281.224 × C, and F 2 = -2.842 + 2725.137 × A - 1307.688 × B + 231.353 × C. A, B and C represent the simulated flow velocity generated by inflow parameter values of 16, 40 and 80 m(3) s(-1), respectively. The model correctly predicts 88.9 and 100.0 % of sampling locations consisting of relatively high and low sand mass percentages, respectively, with the cross-validated classification showing that, overall, 82.8 % are

  3. Functions of axon guidance molecules in synapse formation

    OpenAIRE

    Chen, Shih-Yu; Cheng, Hwai-Jong

    2009-01-01

    Axon guidance and synapse formation are important developmental events for establishing a functional neuronal circuitry. These two related cellular processes occur in a coordinated fashion but previous studies from multiple model organisms seemed to suggest that axon guidance and synapse formation are mediated by distinct molecular cues. Thus, axon guidance molecules are responsible for guiding the navigating axon toward its target area, while other adhesion or ligand-receptor molecules speci...

  4. Initiation and blocking of the action potential in the axon in a weak ultrasonic field

    CERN Document Server

    Shneider, M N

    2013-01-01

    It is shown that the longitudinal standing ultrasonic wave of low intensity leads to the lateral drift and to redistribution of the transmembrane ion channels in the initial segment of the myelinated axon of a neuron. The analysis is based on the Hodgkin - Huxley model of an axon. Redistribution of the density of transmembrane sodium channels, caused by ultrasound, may reduce the threshold of the action potential, up to its spontaneous initiation. At significant redistribution of sodium channels in membrane, the zones of rarefaction of the transmembrane channels density are formed blocking the propagation of the action potential. After switching the ultrasound off, the unperturbed uniform distribution of transmembrane channels in the axon recovers due to lateral diffusion. The blocking effect of the action potential can be used in anesthesia.

  5. Precursor and mature NGF live tracking: one versus many at a time in the axons.

    Science.gov (United States)

    De Nadai, Teresa; Marchetti, Laura; Di Rienzo, Carmine; Calvello, Mariantonietta; Signore, Giovanni; Di Matteo, Pierluigi; Gobbo, Francesco; Turturro, Sabrina; Meucci, Sandro; Viegi, Alessandro; Beltram, Fabio; Luin, Stefano; Cattaneo, Antonino

    2016-01-01

    The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its mature counterpart. Here we developed a strategy to fluorolabel both purified precursor and mature neurotrophins (NTs) with a controlled stoichiometry and insertion site. Using a single particle tracking approach, we characterized the axonal transport of proNGF versus mature NGF in living dorsal root ganglion neurons grown in compartmentalized microfluidic devices. We demonstrate that proNGF is retrogradely transported as NGF, but with a lower flux and a different distribution of numbers of neurotrophins per vesicle. Moreover, exploiting a dual-color labelling technique, we analysed the transport of both NT forms when simultaneously administered to the axon tips. PMID:26829890

  6. Morphometry of Axons in Optic Nerves of Siamese's Twins

    Institute of Scientific and Technical Information of China (English)

    Xinzu Gu; Zhenping Zhang; Qi Lin; Jiongji Liang; Wenyu Lu; Xiulan Ye; A A Sadun

    2002-01-01

    Purpose: To observe the development of optic nerve, we examined four optic nerves from Siameses Twins by absolute counts of axons.Methods: Mean axon diameter, mean axon density, totally axonal population and optic nerve area were noted for each optic nerve. The mean axon diameter and the mean axon density were compared between paraxial (inner sectors)and cortical (outer sectors)areas of the nerves.Results: More myelinated axons were seen in the inner sectors as compared to the outer sectors(average 11 axons/1 000 μm2 in inner sectors and 34 axons/l 000 μm2 in outer sectors( P=0. 036) . The myelinated fibers were also smaller(63 microns) in the outer sectors as compared to the inner sectors(72 microns) ( P = 0. 001 ). The average cross sectors area for the four 40 week stage optical nerves of Siamese Twins was 3.32 × 103 as compared to 1 million axons for 32-week-old normals.Conclusion: Our finding of fewer axonal number and small myelinated fibers in the Siamese Twins suggests hypoplasia. Myelination was more abnormal in the paraxial optic nerve than that in the peripheral sectors, suggesting anomalous development of optic nerve peripherally and delayed developnent centrally. Axonal density is higher in inner sectors than that in outer sectors, suggesting delayed development of the outer nerve sector.

  7. Electrokinetic confinement of axonal growth for dynamically configurable neural networks.

    Science.gov (United States)

    Honegger, Thibault; Scott, Mark A; Yanik, Mehmet F; Voldman, Joel

    2013-02-21

    Axons in the developing nervous system are directed via guidance cues, whose expression varies both spatially and temporally, to create functional neural circuits. Existing methods to create patterns of neural connectivity in vitro use only static geometries, and are unable to dynamically alter the guidance cues imparted on the cells. We introduce the use of AC electrokinetics to dynamically control axonal growth in cultured rat hippocampal neurons. We find that the application of modest voltages at frequencies on the order of 10(5) Hz can cause developing axons to be stopped adjacent to the electrodes while axons away from the electric fields exhibit uninhibited growth. By switching electrodes on or off, we can reversibly inhibit or permit axon passage across the electrodes. Our models suggest that dielectrophoresis is the causative AC electrokinetic effect. We make use of our dynamic control over axon elongation to create an axon-diode via an axon-lock system that consists of a pair of electrode 'gates' that either permit or prevent axons from passing through. Finally, we developed a neural circuit consisting of three populations of neurons, separated by three axon-locks to demonstrate the assembly of a functional, engineered neural network. Action potential recordings demonstrate that the AC electrokinetic effect does not harm axons, and Ca(2+) imaging demonstrated the unidirectional nature of the synaptic connections. AC electrokinetic confinement of axonal growth has potential for creating configurable, directional neural networks. PMID:23314575

  8. Spatial temperature gradients guide axonal outgrowth

    Science.gov (United States)

    Black, Bryan; Vishwakarma, Vivek; Dhakal, Kamal; Bhattarai, Samik; Pradhan, Prabhakar; Jain, Ankur; Kim, Young-Tae; Mohanty, Samarendra

    2016-07-01

    Formation of neural networks during development and regeneration after injury depends on accuracy of axonal pathfinding, which is primarily believed to be influenced by chemical cues. Recently, there is growing evidence that physical cues can play crucial role in axonal guidance. However, detailed mechanism involved in such guidance cues is lacking. By using weakly-focused near-infrared continuous wave (CW) laser microbeam in the path of an advancing axon, we discovered that the beam acts as a repulsive guidance cue. Here, we report that this highly-effective at-a-distance guidance is the result of a temperature field produced by the near-infrared laser light absorption. Since light absorption by extracellular medium increases when the laser wavelength was red shifted, the threshold laser power for reliable guidance was significantly lower in the near-infrared as compared to the visible spectrum. The spatial temperature gradient caused by the near-infrared laser beam at-a-distance was found to activate temperature-sensitive membrane receptors, resulting in an influx of calcium. The repulsive guidance effect was significantly reduced when extracellular calcium was depleted or in the presence of TRPV1-antagonist. Further, direct heating using micro-heater confirmed that the axonal guidance is caused by shallow temperature-gradient, eliminating the role of any non-photothermal effects.

  9. Axonal PPARγ promotes neuronal regeneration after injury.

    Science.gov (United States)

    Lezana, Juan Pablo; Dagan, Shachar Y; Robinson, Ari; Goldstein, Ronald S; Fainzilber, Mike; Bronfman, Francisca C; Bronfman, Miguel

    2016-06-01

    PPARγ is a ligand-activated nuclear receptor best known for its involvement in adipogenesis and glucose homeostasis. PPARγ activity has also been associated with neuroprotection in different neurological disorders, but the mechanisms involved in PPARγ effects in the nervous system are still unknown. Here we describe a new functional role for PPARγ in neuronal responses to injury. We found both PPAR transcripts and protein within sensory axons and observed an increase in PPARγ protein levels after sciatic nerve crush. This was correlated with increased retrograde transport of PPARγ after injury, increased association of PPARγ with the molecular motor dynein, and increased nuclear accumulation of PPARγ in cell bodies of sensory neurons. Furthermore, PPARγ antagonists attenuated the response of sensory neurons to sciatic nerve injury, and inhibited axonal growth of both sensory and cortical neurons in culture. Thus, axonal PPARγ is involved in neuronal injury responses required for axonal regeneration. Since PPARγ is a major molecular target of the thiazolidinedione (TZD) class of drugs used in the treatment of type II diabetes, several pharmaceutical agents with acceptable safety profiles in humans are available. Our findings provide motivation and rationale for the evaluation of such agents for efficacy in central and peripheral nerve injuries. PMID:26446277

  10. Early cellular signaling responses to axonal injury

    Directory of Open Access Journals (Sweden)

    Wang Ai

    2009-03-01

    Full Text Available Abstract Background We have used optic nerve injury as a model to study early signaling events in neuronal tissue following axonal injury. Optic nerve injury results in the selective death of retinal ganglion cells (RGCs. The time course of cell death takes place over a period of days with the earliest detection of RGC death at about 48 hr post injury. We hypothesized that in the period immediately following axonal injury, there are changes in the soma that signal surrounding glia and neurons and that start programmed cell death. In the current study, we investigated early changes in cellular signaling and gene expression that occur within the first 6 hrs post optic nerve injury. Results We found evidence of cell to cell signaling within 30 min of axonal injury. We detected differences in phosphoproteins and gene expression within the 6 hrs time period. Activation of TNFα and glutamate receptors, two pathways that can initiate cell death, begins in RGCs within 6 hrs following axonal injury. Differential gene expression at 6 hrs post injury included genes involved in cytokine, neurotrophic factor signaling (Socs3 and apoptosis (Bax. Conclusion We interpret our studies to indicate that both neurons and glia in the retina have been signaled within 30 min after optic nerve injury. The signals are probably initiated by the RGC soma. In addition, signals activating cellular death pathways occur within 6 hrs of injury, which likely lead to RGC degeneration.

  11. Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain

    OpenAIRE

    Larsen, Camilla; Shy, Diana; Spindler, Shana R; Fung, Siaumin; Pereanu, Wayne; Younossi -Hartenstein, Amelia; Hartenstein, Volker

    2009-01-01

    The Drosophila central brain is composed of approximately 100 paired lineages, with most lineages comprising 100–150 neurons. Most lineages have a number of important characteristics in common. Typically, neurons of a lineage stay together as a coherent cluster and project their axons into a coherent bundle visible from late embryo to adult. Neurons born during the embryonic period form the primary axon tracts (PATs) that follow stereotyped pathways in the neuropile. Apoptotic cell death remo...

  12. White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis

    Science.gov (United States)

    Cambron, Melissa; D'Haeseleer, Miguel; Laureys, Guy; Clinckers, Ralph; Debruyne, Jan; De Keyser, Jacques

    2012-01-01

    In patients with multiple sclerosis (MS), a diffuse axonal degeneration occurring throughout the white matter of the central nervous system causes progressive neurologic disability. The underlying mechanism is unclear. This review describes a number of pathways by which dysfunctional astrocytes in MS might lead to axonal degeneration. White-matter astrocytes in MS show a reduced metabolism of adenosine triphosphate-generating phosphocreatine, which may impair the astrocytic sodium potassium pump and lead to a reduced sodium-dependent glutamate uptake. Astrocytes in MS white matter appear to be deficient in β2 adrenergic receptors, which are involved in stimulating glycogenolysis and suppressing inducible nitric oxide synthase (NOS2). Glutamate toxicity, reduced astrocytic glycogenolysis leading to reduced lactate and glutamine production, and enhanced nitric oxide (NO) levels may all impair axonal mitochondrial metabolism, leading to axonal degeneration. In addition, glutamate-mediated oligodendrocyte damage and impaired myelination caused by a decreased production of N-acetylaspartate by axonal mitochondria might also contribute to axonal loss. White-matter astrocytes may be considered as a potential target for neuroprotective MS therapies. PMID:22214904

  13. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria

    OpenAIRE

    Kitay, Brandon M.; McCormack, Ryan; Wang, Yunfang; Tsoulfas, Pantelis; Zhai, R. Grace

    2013-01-01

    Axon degeneration is a common and often early feature of neurodegeneration that correlates with the clinical manifestations and progression of neurological disease. Nicotinamide mononucleotide adenylytransferase (NMNAT) is a neuroprotective factor that delays axon degeneration following injury and in models of neurodegenerative diseases suggesting a converging molecular pathway of axon self-destruction. The underlying mechanisms have been under intense investigation and recent reports suggest...

  14. AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage

    Directory of Open Access Journals (Sweden)

    Yang Li

    2014-02-01

    Full Text Available Published methods for imaging and quantitatively analyzing morphological changes in neuronal axons have serious limitations because of their small sample sizes, and their time-consuming and nonobjective nature. Here we present an improved microfluidic chamber design suitable for fast and high-throughput imaging of neuronal axons. We developed the AxonQuant algorithm, which is suitable for automatic processing of axonal imaging data. This microfluidic chamber-coupled algorithm allows calculation of an ‘axonal continuity index' that quantitatively measures axonal health status in a manner independent of neuronal or axonal density. This method allows quantitative analysis of axonal morphology in an automatic and nonbiased manner. Our method will facilitate large-scale high-throughput screening for genes or therapeutic compounds for neurodegenerative diseases involving axonal damage. When combined with imaging technologies utilizing different gene markers, this method will provide new insights into the mechanistic basis for axon degeneration. Our microfluidic chamber culture-coupled AxonQuant algorithm will be widely useful for studying axonal biology and neurodegenerative disorders. © 2014 S. Karger AG, Basel

  15. 3D velocity distribution of P- and S-waves in a biotite gneiss, measured in oil as the pressure medium: Comparison with velocity measurements in a multi-anvil pressure apparatus and with texture-based calculated data

    Czech Academy of Sciences Publication Activity Database

    Lokajíček, Tomáš; Kern, H.; Svitek, Tomáš; Ivankina, T.

    2014-01-01

    Roč. 231, June (2014), s. 1-15. ISSN 0031-9201 R&D Projects: GA MŠk LH13102; GA ČR(CZ) GAP104/12/0915; GA ČR GA13-13967S Institutional support: RVO:67985831 Keywords : 3D-velocity calculation * measured and calculated elastic properties * neutron diffraction * seismic anisotropy * velocity measurements Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 2.895, year: 2014

  16. Stability of ion acoustic solitary waves in a magnetized plasma consisting of warm adiabatic ions and non-thermal electrons having vortex-like velocity distribution

    Science.gov (United States)

    Das, Jayasree; Bandyopadhyay, Anup; Das, K. P.; Das

    2014-02-01

    Schamel's modified Korteweg-de Vries-Zakharov-Kuznetsov (S-ZK) equation, governing the behavior of long wavelength, weak nonlinear ion acoustic waves propagating obliquely to an external uniform static magnetic field in a plasma consisting of warm adiabatic ions and non-thermal electrons (due to the presence of fast energetic electrons) having vortex-like velocity distribution function (due to the presence of trapped electrons), immersed in a uniform (space-independent) and static (time-independent) magnetic field, admits solitary wave solutions having a sech 4 profile. The higher order stability of this solitary wave solution of the S-ZK equation has been analyzed with the help of multiple-scale perturbation expansion method of Allen and Rowlands (Allen, M. A. and Rowlands, G. 1993 J. Plasma Phys. 50, 413; 1995 J. Plasma Phys. 53, 63). The growth rate of instability is obtained correct to the order k 2, where k is the wave number of a long wavelength plane wave perturbation. It is found that the lowest order (at the order k) instability condition is strongly sensitive to the angle of propagation (δ) of the solitary wave with the external uniform static magnetic field, whereas at the next order (at the order k 2) the solitary wave solutions of the S-ZK equation are unstable irrespective of δ. It is also found that the growth rate of instability up to the order k 2 for the electrons having Boltzmann distribution is higher than that of the non-thermal electrons having vortex-like distribution for any fixed δ.

  17. Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases

    Directory of Open Access Journals (Sweden)

    Fang Cheng

    2012-06-01

    Full Text Available Abstract Background Reactive oxygen species (ROS released by microglia and other inflammatory cells can cause axonal degeneration. A reduction in axonal transport has also been implicated as a cause of axonal dystrophies and neurodegeneration, but there is a paucity of experimental data concerning the effects of ROS on axonal transport. We used live cell imaging to examine the effects of hydrogen peroxide on the axonal transport of mitochondria and Golgi-derived vesicles in cultured rat hippocampal neurons. Results Hydrogen peroxide rapidly inhibited axonal transport, hours before any detectable changes in mitochondrial morphology or signs of axonal degeneration. Mitochondrial transport was affected earlier and was more severely inhibited than the transport of Golgi-derived vesicles. Anterograde vesicle transport was more susceptible to peroxide inhibition than retrograde transport. Axonal transport partially recovered following removal of hydrogen peroxide and local application of hydrogen peroxide inhibited transport, suggesting that the effects were not simply a result of nerve cell death. Sodium azide, an ATP synthesis blocker, had similar effects on axonal transport, suggesting that ATP depletion may contribute to the transport inhibition due to hydrogen peroxide. Conclusions These results indicate that inhibition of axonal transport is an early consequence of exposure to ROS and may contribute to subsequent axonal degeneration.

  18. Axon position within the corpus callosum determines contralateral cortical projection.

    Science.gov (United States)

    Zhou, Jing; Wen, Yunqing; She, Liang; Sui, Ya-Nan; Liu, Lu; Richards, Linda J; Poo, Mu-Ming

    2013-07-16

    How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axons were positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex. PMID:23812756

  19. Speciifc effects of c-Jun NH2-terminal kinase-interacting protein 1 in neuronal axons

    Institute of Scientific and Technical Information of China (English)

    Shu Tang; Qiang Wen; Xiao-jian Zhang; Quan-cheng Kan

    2016-01-01

    c-Jun NH2-terminal kinase (JNK)-interacting protein 3 plays an important role in brain-derived neurotrophic factor/tropomyosin-related kinase B (TrkB) anterograde axonal transport. It remains unclear whether JNK-interacting protein 1 mediates similar effects, or whether JNK-interacting protein 1 affects the regulation of TrkB anterograde axonal transport. In this study, we isolated rat embryonic hippocampus and cultured hippocampal neuronsin vitro. Coimmunoprecipitation results demonstrated that JNK-interacting protein 1 formed TrkB com-plexesin vitro andin vivo. Immunocytochemistry results showed that when JNK-interacting protein 1 was highly expressed, the distribution of TrkB gradually increased in axon terminals. However, the distribution of TrkB reduced in axon terminals after knocking out JNK-interact-ing protein 1. In addition, there were differences in distribution of TrkB after JNK-interacting protein 1 was knocked out compared with not. However, knockout of JNK-interacting protein 1 did not affect the distribution of TrkB in dendrites. These ifndings conifrm that JNK-inter-acting protein 1 can interact with TrkB in neuronal cells, and can regulate the transport of TrkB in axons, but not in dendrites.

  20. Development of microarray device for functional evaluation of PC12D cell axonal extension ability

    Science.gov (United States)

    Nakamachi, Eiji; Yanagimoto, Junpei; Murakami, Shinya; Morita, Yusuke

    2014-04-01

    In this study, we developed a microarray bio-MEMS device that could trap PC12D (rat pheochromocytoma cells) cells to examine the intercellular interaction effect on the cell activation and the axonal extension ability. This is needed to assign particular patterns of PC12D cells to establish a cell functional evaluation technique. This experimental observation-based technique can be used for design of the cell sheet and scaffold for peripheral and central nerve regeneration. We have fabricated a micropillar-array bio-MEMS device, whose diameter was approximately 10 μm, by using thick photoresist SU-8 on the glass slide substrate. A maximum trapped PC12D cell ratio, 48.5%, was achieved. Through experimental observation of patterned PC12D "bi-cells" activation, we obtained the following results. Most of the PC12D "bi-cells" which had distances between 40 and 100 μm were connected after 24 h with a high probability. On the other hand, "bi-cells" which had distances between 110 and 200 μm were not connected. In addition, we measured axonal extension velocities in cases where the intercellular distance was between 40 and 100 μm. A maximum axonal extension velocity, 86.4 μm/h, was obtained at the intercellular distance of 40 μm.

  1. Fast axonal transport of labeled proteins in motoneurons of exercise-trained rats

    International Nuclear Information System (INIS)

    In this study, the fast orthograde axonal transport of radiolabeled proteins was measured to determine the effects of endurance-running training on transport velocity and amounts of transported proteins in rat sciatic motoneurons. Female rats were subjected to a progressive running-training program for 10-12 wk. Twenty-four hours after the last training session, rats underwent right L4-L5 dorsal root ganglionectomy. The next day, 20 microCi of [3H]leucine was injected bilaterally in the vicinity of the motoneuronal cell bodies supplying the sciatic nerve, to study axonal transport parameters. Results showed that peak and average transport velocities of labeled proteins were significantly (P less than 0.05) increased by 22 and 29%, respectively, in the deafferented nerves of the runners as compared with controls. Moreover, the amount of total transported protein-bound radioactivity was increased in both left (40%) and right (37%) sciatic nerves of the runners. An exhaustive exercise session reduced (P less than 0.05) peak displacement (8%) and total transported protein-bound radioactivity (36%) in the sciatic nerves of control rats, whereas no changes were noticed in trained animals. The data suggest that chronic endurance running induces significant adaptations in the fast axonal transport of labeled proteins

  2. Axon regeneration impediment:the role of paired immunoglobulin-like receptor B

    Institute of Scientific and Technical Information of China (English)

    Jing Liu; Yan Wang; Wei Fu

    2015-01-01

    Regenerative capacity is weak after central nervous system injury because of the absence of an enhancing microenvironment and presence of an inhibitory microenvironment for neuronal and axonal repair. In addition to the Nogo receptor (NgR), the paired immunoglobulin-like receptor B (PirB) is a recently discovered coreceptor of Nogo, myelin-associated glycoprotein, and myelin oligodendrocyte glycoprotein. Concurrent blocking of NgR and PirB almost completely elim-inates the inhibitory effect of myelin-associated inhibitory molecules on axonal regeneration. PirB participates in a key pathological process of the nervous system, speciifcally axonal regener-ation inhibition. PirB is an inhibitory receptor similar to NgR, but their effects are not identical. This study summarizes the structure, distribution, relationship with common nervous system diseases, and known mechanisms of PirB, and concludes that PirB is also distributed in cells of the immune and hematopoietic systems. Further investigations are needed to determine if im-munomodulation and blood cell migration involve inhibition of axonal regeneration.

  3. Preliminary study on preparation, release velocity and intracorporeal physical distribution of 32P-chromic phosphate-poly (L-lactide) delayed release panicles

    International Nuclear Information System (INIS)

    Objective: The aim of this study was to prepare the 32P-chromic phosphate-poly(L-lac-tide) (32P-CP-PLLA) particles with different ratio of the materials and further examine their performance in-dex in vivo and in vitro and their intracorporeal distribution. Methods: The erosion, degrading rates, delayed release velocity and radioactivity self-absorption coefficient (RSAC) of 32P-CP-PLLA particles made from different materials were investigated and compared. After the implantation of 32P-CP-PLLA particles and the injection of 32P-CP colloids in the muscular tissues, the weight loss rate and the radioactivity release rate (RRR) of the particles were calculated. The intracorporeal distribution, radioactive half-life and bio-logical effect of 32P in the targeting sites were further studied. Statistical analysis was performed with SPSS 12.0, and one-way analysis of variance and t-test were used. Results: 32P-CP-PLLA particles were of green cylinder, with regular shape and radionuclide distribution. The RSAC of the particles was of little relation with molecular weight of PLLA and proportional to the ratio of PLLA to CP. The extracorporeal release rate increased with the reduction of molecular weight of PLLA and with the increase of the ratio of PLLA to CP. The RRR reached peak when PLLA was 3 times of CP. The 32P-CP, released with the degradation and corrosion of the particle distributed mainly in the surrounding muscles of the particle. And the peak of percentage activity of injection dose per gram of tissue (% ID/g) in liver, spleen and bone were 1. 7887, 1. 6401 and 1. 9470 respectively, much lower than that in the 32P-CP group (4.7523, 3.9712 and 4.3174 ; all t > 2.7, all P 32P-CP-PLLA, which can increase the targeting radioactive dosage and effective half-life in the implanting sites, can be served as an potential implanting agent for onco-therapy with a better perspective. (authors)

  4. Axonal transport of enzymes and labeled proteins in experimental axonopathy induced by p-bromophenylacetylurea

    International Nuclear Information System (INIS)

    Axonal transport was studied by several techniques in the sciatic nerves of adult male Sprague-Dawley rats with neuropathy induced by treatment with p-bromophenylacetylurea (BPAU) in dimethylsulfoxide solution. Control rats were treated with solvent alone. BPAU, 200 mg/kg, induced severe muscle weakness in the hindlimbs, beginning after a latent period of 1 week and progressing to near total paralysis by 2 weeks. Axonal transport of the endogenous transmitter enzymes, acetylcholinesterase, dopamine-β-hydroxylase and choline acetyltransferase, was normal at both 2 and 15 days after administration of BPAU, as judged by the accumulation of enzyme activity above and below a set of double ligatures on the sciatic nerve. The velocity of fast anterograde transport of [35S]methionine labeled protein was also unaffected by BPAU. However, 4 abnormalities of transport were detected in BPAU treated rats. These abnormalities are discussed. (Auth.)

  5. Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons

    Directory of Open Access Journals (Sweden)

    Philip R Lee

    2009-06-01

    Full Text Available Myelination is a highly dynamic process that continues well into adulthood in humans. Several recent gene expression studies have found abnormal expression of genes involved in myelination in the prefrontal cortex of brains from patients with schizophrenia and other psychiatric illnesses. Defects in myelination could contribute to the pathophysiology of psychiatric illness by impairing information processing as a consequence of altered impulse conduction velocity and synchrony between cortical regions carrying out higher level cognitive functions. Myelination can be altered by impulse activity in axons and by environmental experience. Psychiatric illness is treated by psychotherapy, behavioral modification, and drugs affecting neurotransmission, raising the possibility that myelinating glia may not only contribute to such disorders, but that activity-dependent effects on myelinating glia could provide one of the cellular mechanisms contributing to the therapeutic effects of these treatments. This review examines evidence showing that genes and gene networks important for myelination can be regulated by functional activity in axons.

  6. Distribution and inventories of fallout radionuclides (239+24Pu, 137Cs) and 21Pb to study the filling velocity of salt marshes in Donana National Park (Spain)

    International Nuclear Information System (INIS)

    Within an extensive multinational and multidisciplinary project carried out in Donana National Park (Spain) to investigate its preservation and regeneration, the filling velocity of the salt marshes has been evaluated through the calculation of their average sediment accumulation rates. 239+24Pu and 137Cs from weapons testing fallout and total 21Pb distribution profiles and inventories have been determined in some of the most characteristic zones of the park, namely, the ponds (or 'lucios') and the waterjets (or 'canos'). Plutonium inventories range from 16 to 101 Bq m-2, 137Cs values fluctuate between 514 and 3758 Bq m-2 and unsupported 21Pb values comprise between 124 and 9398 Bq m-2. Average sedimentation rates range from 3 to 5 mm y-1 (1952-2002). These data are higher than those obtained by carbon dating for the period 6500 AD-present, estimated as 1.5-2 mm y-1, suggesting an increase in the accumulation of sediments and the alteration of the park's hydrodynamics caused by the re-channeling of the major rivers feeding the salt marshes

  7. Characterization of sub-cloud vertical velocity distributions and precipitation-driven outflow dynamics using a ship-based, scanning Doppler lidar during VOCALS-Rex

    Science.gov (United States)

    Brewer, A.; Feingold, G.; Tucker, S. C.; Covert, D. S.; Hardesty, R.

    2010-12-01

    During the VOCALS Regional Experiment NOAA's High Resolution Doppler Lidar (HRDL) operated from the RV Ronald H. Brown and made continuous measurements of sub-cloud horizontal and vertical wind speed and aerosol backscatter signal strength. We will present averaged profiles of vertical velocity distributions and turbulence parameters, stratified by a range of conditions including diurnal variation, precipitation, and distance from shore. The results point to a strong diurnal dependence in the strength of turbulence with nighttime conditions exhibiting stronger subcloud variance. Skewness shows less diurnal sensitivity with a trend towards more negative skewness near cloud base. Combining HRDL’s scanning horizontal wind speed measurements with other ship based in-situ and remote sensing measurements, we investigate the dynamics of precipitation-driven outflows and their impact on surface thermodynamic and aerosol properties. Using a sample of over 150 airmass transitions over the course of the 5 week deployment, we observed that warmer outflow air is typically drier, has less aerosol scattering and tends to have higher ozone concentrations (indicating the transport of air from above the boundary layer top). Transitions to cooler air are generally moister, have more aerosol scattering and show no significant change in ozone concentration. We will present animations of combined lidar/radar/GOES imagery that were used to facilitate visualization and interpretation of the dynamics of the outflows.

  8. Study of velocity and shear stress distributions in the impeller passages and the volute of a bio-centrifugal ventricular assist device.

    Science.gov (United States)

    Chua, Leok Poh; Ong, Kang Shiu; Song, Guoliang

    2008-05-01

    The velocity fields within the impeller passages of three different impellers of the Kyoto-NTN bio-centrifugal ventricular assist device are measured using laser Doppler velocimetry in this study. The 16 forward-swept-blade impeller has better performance than the 16 straight-blade and 8 backward-swept-blade impellers in terms of smooth flow pattern, and has less high-shear-stress regions in the passages. The flow distributions are found to be similar with those measured by Yu et al. Through-flow characteristics are found in the impeller when the passages open to the biggest volute space. The flow fields in the blade channels of the impeller were found to be axis symmetrical due to the double volute design with the objective of minimizing the imbalance of the radial thrust when the impeller is magnetically suspended. In addition, the high-intensity vortex which was detected by Yu et al. at the discharge channel of the pump is effectively reduced when the end of the splitter plate is modified by increasing the taper ratio from 4 to 20. The new design would reduce the hemolysis of blood due to the high shear rate of the vortex. PMID:18471167

  9. Constraints on the Velocity and Spatial Distribution of Helium-like Ions in the Wind of SMC X-1 from Observations with XMM-Newton/RGS

    CERN Document Server

    Wojdowski, Patrick S; Kallman, Timothy R

    2007-01-01

    We present here X-ray spectra of the HMXB SMC X-1 obtained in an observation with the XMM observatory beginning before eclipse and ending near the end of eclipse. With the Reflection Grating Spectrometers (RGS) on board XMM, we observe emission lines from hydrogen-like and helium-like ions of nitrogen, oxygen, neon, magnesium, and silicon. Though the resolution of the RGS is sufficient to resolve the helium-like n=2->1 emission into three line components, only one of these components, the intercombination line, is detected in our data. The lack of flux in the forbidden lines of the helium-like triplets is explained by pumping by ultraviolet photons from the B0 star and, from this, we set an upper limit on the distance of the emitting ions from the star. The lack of observable flux in the resonance lines of the helium-like triplets indicate a lack of enhancement due to resonance line scattering and, from this, we derive a new observational constraint on the distribution of the wind in SMC X-1 in velocity and c...

  10. Orbital velocity

    CERN Document Server

    Modestino, Giuseppina

    2016-01-01

    The trajectory and the orbital velocity are determined for an object moving in a gravitational system, in terms of fundamental and independent variables. In particular, considering a path on equipotential line, the elliptical orbit is naturally traced, verifying evidently the keplerian laws. The case of the planets of the solar system is presented.

  11. Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.

    Science.gov (United States)

    Edgar, Julia M; McLaughlin, Mark; Werner, Hauke B; McCulloch, Mailis C; Barrie, Jennifer A; Brown, Angus; Faichney, Andrew Blyth; Snaidero, Nicolas; Nave, Klaus-Armin; Griffiths, Ian R

    2009-12-01

    Most axons in the central nervous system (CNS) are surrounded by a multilayered myelin sheath that promotes fast, saltatory conduction of electrical impulses. By insulating the axon, myelin also shields the axoplasm from the extracellular milieu. In the CNS, oligodendrocytes provide support for the long-term maintenance of myelinated axons, independent of the myelin sheath. Here, we use electron microscopy and morphometric analyses to examine the evolution of axonal and oligodendroglial changes in mice deficient in 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and in mice deficient in both CNP and proteolipid protein (PLP/DM20). We show that CNP is necessary for the formation of a normal inner tongue process of oligodendrocytes that myelinate small diameter axons. We also show that axonal degeneration in Cnp1 null mice is present very early in postnatal life. Importantly, compact myelin formed by transplanted Cnp1 null oligodendrocytes induces the same degenerative changes in shiverer axons that normally are dysmyelinated but structurally intact. Mice deficient in both CNP and PLP develop a more severe axonal phenotype than either single mutant, indicating that the two oligodendroglial proteins serve distinct functions in supporting the myelinated axon. These observations support a model in which the trophic functions of oligodendrocytes serve to offset the physical shielding of axons by myelin membranes. PMID:19459211

  12. Application of the subroutine SYSTD in the analytical determination of the laws of velocity and temperature distributions for turbulent flow in air

    International Nuclear Information System (INIS)

    The variation of velocity and temperature profiles for turbulent flow in air is obtained theoretically when the physical properties of the air vary with temperature. By adopting certain assumptions, a set of equations is derived which are used with the help of the computer sub-routine SYSTD, to obtain the velocity and temperature profiles

  13. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination

    OpenAIRE

    Freeman, Sean A.; Desmazières, Anne; Simonnet, Jean; Gatta, Marie; Pfeiffer, Friederike; Aigrot, Marie Stéphane; Rappeneau, Quentin; Guerreiro, Serge; Michel, Patrick Pierre; Yanagawa, Yuchio; Barbin, Gilles; Brophy, Peter. J.; Fricker, Desdemona; Lubetzki, Catherine; Sol-Foulon, Nathalie

    2015-01-01

    Cellular and molecular mechanisms underlying the assembly of nodes of Ranvier of myelinated axons in the CNS are still only partly understood. Our study shows the influence of intrinsic cues and glial extrinsic factors for nodal protein clustering before myelination on specific hippocampal neuronal subpopulations and extends to electrophysiological understandings and in vivo relevance. Although conduction velocity along axons has long been thought to mostly rely on the insulating properties o...

  14. Axonal Protein Synthesis and the Regulation of Local Mitochondrial Function

    OpenAIRE

    2009-01-01

    Axons and presynaptic nerve terminals of both invertebrate and mammalian SCG neurons contain a heterogeneous population of nuclear-encoded mitochondrial mRNAs and a local cytosolic protein synthetic system. Nearly one quarter of the total protein synthesized in these structural/functional domains of the neuron is destined for mitochondria. Acute inhibition of axonal protein synthesis markedly reduces the functional activity of mitochondria. The blockade of axonal protein into mitochondria had...

  15. Axonal protein synthesis and the regulation of local mitochondrial function

    OpenAIRE

    Kaplan, B.B.; Gioio, A.E.; Hillefors, M.; Aschrafi, A.

    2009-01-01

    Axons and presynaptic nerve terminals of both invertebrate and mammalian SCG neurons contain a heterogeneous population of nuclear-encoded mitochondrial mRNAs and a local cytosolic protein synthetic system. Nearly one quarter of the total protein synthesized in these structural/functional domains of the neuron is destined for mitochondria. Acute inhibition of axonal protein synthesis markedly reduces the functional activity of mitochondria. The blockade of axonal protein into mitochondria had...

  16. Action potentials reliably invade axonal arbors of rat neocortical neurons

    OpenAIRE

    Cox, Charles L.; Denk, Winfried; Tank, David W.; Svoboda, Karel

    2000-01-01

    Neocortical pyramidal neurons have extensive axonal arborizations that make thousands of synapses. Action potentials can invade these arbors and cause calcium influx that is required for neurotransmitter release and excitation of postsynaptic targets. Thus, the regulation of action potential invasion in axonal branches might shape the spread of excitation in cortical neural networks. To measure the reliability and extent of action potential invasion into axonal arbors, we have used two-photon...

  17. Axon diameter mapping in crossing fibers with diffusion MRI

    DEFF Research Database (Denmark)

    Zhang, Hui; Dyrby, Tim B; Alexander, Daniel C

    2011-01-01

    tissue than measures derived from diffusion tensor imaging. Most existing techniques for axon diameter mapping assume a single axon orientation in the tissue model, which limits their application to only the most coherently oriented brain white matter, such as the corpus callosum, where the single...... technique by establishing reasonable axon diameter indices in the crossing region at the interface of the cingulum and the corpus callosum....

  18. Axon target matching in the developing visual system

    OpenAIRE

    Osterhout, Jessica A.

    2015-01-01

    The central nervous system (CNS) is made up of trillions of connections between specific sets of highly specialized neurons. How each individual neuron finds and connects to the correct synaptic partner remains an important and unresolved issue in neuroscience. Using the mouse visual system as a model I probed the cellular and molecular mechanisms that govern one of the key steps leading to CNS development: axon target matching. Axon target matching is the process by which axons to find and i...

  19. Axon Regeneration in the Peripheral and Central Nervous Systems

    OpenAIRE

    Huebner, Eric A.; Strittmatter, Stephen M

    2009-01-01

    Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long- distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsi...

  20. Myelin sheath survival after guanethidine-induced axonal degeneration

    OpenAIRE

    1992-01-01

    Membrane-membrane interactions between axons and Schwann cells are required for initial myelin formation in the peripheral nervous system. However, recent studies of double myelination in sympathetic nerve have indicated that myelin sheaths continue to exist after complete loss of axonal contact (Kidd, G. J., and J. W. Heath. 1988. J. Neurocytol. 17:245-261). This suggests that myelin maintenance may be regulated either by diffusible axonal factors or by nonaxonal mechanisms. To test these hy...

  1. Axonal autophagy during regeneration of the rat sciatic nerve

    Institute of Scientific and Technical Information of China (English)

    Kangrong Lu; Zhongxian Piao; Zhenxi Liu; Weiwang Gu; Wanshan Wang; Nngjie Piao

    2008-01-01

    BACKGROUND: The removal of degenerated axonal debris during Wallerian degeneration is very important for nerve regeneration. However, the mechanism by which debris is removed is not been completely understood. Considerable controversy remains as to the clearance pathway and cells that are involved. OBJECTIVE: To investigate axonal autophagy during removal of degenerated axonal debris by transecting the sciatic nerve in a rat Wallerian degeneration model.DESIGN, TIME AND SETTING: Experimental neuropathological analysis. The experiment was conducted at the Laboratory Animal Service Center of the Southern Medical University between January and June 2005. MATERIALS: Fifty-four adult, Wistar rats of either sex, weighing 180-250 g, were obtained from the Laboratory Animal Service Center of the Southern Medical University. Animals were randomly divided into nine groups of six rats. METHODS: Wallerian degeneration was induced by transecting the rat sciatic nerve, and tissue samples from the distal stump were obtained 0.2, 0.4, 1, 2, 3, 4, 7, 10, and 15 days post-transection. Ultrathin sections were prepared for electron microscopy to study ultrastructure and enzyme cytochemistry staining. MAIN OUTCOME MEASURES: Ultrastructure (axon body, autophagic body, and cystoskeleton) of axons and myelin sheaths observed with electron microscopy; acidic phosphatase activity detected by Gomori staining using electron microscopy. RESULTS: The major changes of degenerating axons after transection were axoplasm swelling and separation of axons from their myelin sheath between five hours and two days post-transection. At four days post-transection, the axoplasm condensed and axons were completely separated from the myelin sheath, forming dissociative axon bodies. Vacuoles of different sizes formed in axons during the early phase after lesion. Larger dissociative axon bodies were formed when the axons were completely separated from the myelin sheath during a late phase. The axolemma

  2. Subtle paranodal injury slows impulse conduction in a mathematical model of myelinated axons.

    Directory of Open Access Journals (Sweden)

    Charles F Babbs

    Full Text Available This study explores in detail the functional consequences of subtle retraction and detachment of myelin around the nodes of Ranvier following mild-to-moderate crush or stretch mediated injury. An equivalent electrical circuit model for a series of equally spaced nodes of Ranvier was created incorporating extracellular and axonal resistances, paranodal resistances, nodal capacitances, time varying sodium and potassium currents, and realistic resting and threshold membrane potentials in a myelinated axon segment of 21 successive nodes. Differential equations describing membrane potentials at each nodal region were solved numerically. Subtle injury was simulated by increasing the width of exposed nodal membrane in nodes 8 through 20 of the model. Such injury diminishes action potential amplitude and slows conduction velocity from 19.1 m/sec in the normal region to 7.8 m/sec in the crushed region. Detachment of paranodal myelin, exposing juxtaparanodal potassium channels, decreases conduction velocity further to 6.6 m/sec, an effect that is partially reversible with potassium ion channel blockade. Conduction velocity decreases as node width increases or as paranodal resistance falls. The calculated changes in conduction velocity with subtle paranodal injury agree with experimental observations. Nodes of Ranvier are highly effective but somewhat fragile devices for increasing nerve conduction velocity and decreasing reaction time in vertebrate animals. Their fundamental design limitation is that even small mechanical retractions of myelin from very narrow nodes or slight loosening of paranodal myelin, which are difficult to notice at the light microscopic level of observation, can cause large changes in myelinated nerve conduction velocity.

  3. KIF4 Mediates Anterograde Translocation and Positioning of Ribosomal Constituents to Axons*S⃞

    OpenAIRE

    Bisbal, Mariano; Wojnacki, José; Peretti, Diego; Ropolo, Andrea; Sesma, Juliana; Jausoro, Ignacio; Cáceres, Alfredo

    2009-01-01

    In this study, we have used a combination of biochemical and molecular biology techniques to demonstrate that the C-terminal tail domain of KIF4 directly interacts with P0, a major protein component of ribosomes. Besides, in dorsal root ganglion neurons, KIF4 and P0, as well as other ribosomal constituents, colocalize in clusters distributed along axons and neuritic tips. RNA interference suppression of KIF4 or expression of KIF4 variants lacking the tail domain or mut...

  4. Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

    OpenAIRE

    Brown, Solange P.; Hestrin, Shaul

    2009-01-01

    Cortical columns generate separate streams of information that are distributed to numerous cortical and subcortical brain regions1. We asked whether local intracortical circuits reflect these different processing streams by testing if the intracortical connectivity among pyramids reflects their long-range axonal targets. We recorded simultaneously from up to four retrogradely labelled pyramids that projected to the superior colliculus, the contralateral striatum or the contralateral cortex to...

  5. Axonal transport of proteoglycans to the goldfish optic tectum

    International Nuclear Information System (INIS)

    The study addressed the question of whether 35SO4 labeled molecules that have been delivered to the goldfish optic nerve terminals by rapid axonal transport include soluble proteoglycans. For analysis, tectal homogenates were subfractionated into a soluble fraction (soluble after centrifugation at 105,000 g), a lysis fraction (soluble after treatment with hypotonic buffer followed by centrifugation at 105,000 g) and a final 105,000 g pellet fraction. The soluble fraction contained 25.7% of incorporated radioactivity and upon DEAE chromatography was resolved into a fraction of sulfated glycoproteins eluting at 0-0.32 M NaCl and containing 39.5% of total soluble label and a fraction eluting at 0.32-0.60 M NaCl containing 53.9% of soluble label. This latter fraction was included on columns of Sepharose CL-6B with or without 4 M guanidine and after pronase digestion was found to have 51% of its radioactivity contained in the glycosaminoglycans (GAGs) heparan sulfate and chondroitin (4 or 6) sulfate in the ratio of 70% to 30%. Mobility of both intact proteoglycans and constituent GAGs on Sepharose CL-6B indicated a size distribution that is smaller than has been observed for proteoglycans and GAGs from cultured neuronal cell lines. Similar analysis of lysis fraction, containing 11.5% of incorporated 35SO4, showed a mixture of heparan sulfate and chondroitin sulfate containing proteoglycans, apparent free heparan sulfate and few, if any, sulfated glycoproteins. Overall, the results support the hypothesis that soluble proteoglycans are among the molecules axonally transported in the visual system

  6. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.

    Science.gov (United States)

    Greenberg, Milton L; Weinger, Jason G; Matheu, Melanie P; Carbajal, Kevin S; Parker, Ian; Macklin, Wendy B; Lane, Thomas E; Cahalan, Michael D

    2014-06-01

    Neural precursor cells (NPCs) offer a promising approach for treating demyelinating diseases. However, the cellular dynamics that underlie transplanted NPC-mediated remyelination have not been described. Using two-photon imaging of a newly developed ventral spinal cord preparation and a viral model of demyelination, we describe the motility and intercellular interactions of transplanted mouse NPCs expressing green fluorescent protein (GFP) with damaged axons expressing yellow fluorescent protein (YFP). Our findings reveal focal axonal degeneration that occurs in the ventral side of the spinal cord within 1 wk following intracranial instillation with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Axonal damage precedes extensive demyelination and is characterized by swelling along the length of the axon, loss of YFP signal, and transected appearance. NPCs engrafted into spinal cords of JHMV-infected mice exhibited diminished migration velocities and increased proliferation compared with transplanted cells in noninfected mice. NPCs preferentially accumulated within areas of axonal damage, initiated direct contact with axons, and subsequently expressed the myelin proteolipid protein gene, initiating remyelination. These findings indicate that NPCs transplanted into an inflammatory demyelinating microenvironment participate directly in therapeutic outcome through the wrapping of myelin around damaged neurons. PMID:24843159

  7. Axonal Transmission in the Retina Introduces a Small Dispersion of Relative Timing in the Ganglion Cell Population Response

    OpenAIRE

    Zeck, G; Lambacher, A.; Fromherz, P

    2011-01-01

    Background: Visual stimuli elicit action potentials in tens of different retinal ganglion cells. Each ganglion cell type responds with a different latency to a given stimulus, thus transforming the high-dimensional input into a temporal neural code. The timing of the first spikes between different retinal projection neurons cells may further change along axonal transmission. The purpose of this study is to investigate if intraretinal conduction velocity leads to a synchronization or dispersio...

  8. New insights into mRNA trafficking in axons

    NARCIS (Netherlands)

    Gumy, Laura; Katrukha, Eugene; Kapitein, Lukas; Hoogenraad, Casper

    2014-01-01

    In recent years, it has been demonstrated that mRNAs localize to axons of young and mature central and peripheral nervous system neurons in culture and in vivo. Increasing evidence is supporting a fundamental role for the local translation of these mRNAs in neuronal function by regulating axon growt

  9. The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons

    OpenAIRE

    Einheber, Steven; Maurel, Patrice; Meng, Xiaosong; Rubin, Marina; Lam, Isabel; Mohandas, Narla; An, Xiuli; Shrager, Peter; Kissil, Joseph; Salzer, James L.

    2012-01-01

    Myelinated axons are organized into specialized domains critical to their function in saltatory conduction, i.e. nodes, paranodes, juxtaparanodes, and internodes. Here, we describe the distribution and role of the 4.1B protein in this organization. 4.1B is expressed by neurons, and at lower levels by Schwann cells, which also robustly express 4.1G. Immunofluorescence and immuno-EM demonstrates 4.1B is expressed subjacent to the axon membrane in all domains except the nodes. Mice deficient in ...

  10. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons.

    Science.gov (United States)

    Bei, Fengfeng; Lee, Henry Hing Cheong; Liu, Xuefeng; Gunner, Georgia; Jin, Hai; Ma, Long; Wang, Chen; Hou, Lijun; Hensch, Takao K; Frank, Eric; Sanes, Joshua R; Chen, Chinfei; Fagiolini, Michela; He, Zhigang

    2016-01-14

    Although a number of repair strategies have been shown to promote axon outgrowth following neuronal injury in the mammalian CNS, it remains unclear whether regenerated axons establish functional synapses and support behavior. Here, in both juvenile and adult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of retinal axons and formation of functional synapses in the superior colliculus (SC) but not significant recovery of visual function. Further analyses suggest that regenerated axons fail to conduct action potentials from the eye to the SC due to lack of myelination. Consistent with this idea, administration of voltage-gated potassium channel blockers restores conduction and results in increased visual acuity. Thus, enhancing both regeneration and conduction effectively improves function after retinal axon injury. PMID:26771493

  11. Receptor Tyrosine Kinases: Molecular Switches Regulating CNS Axon Regeneration

    Directory of Open Access Journals (Sweden)

    Vasanthy Vigneswara

    2012-01-01

    Full Text Available The poor or lack of injured adult central nervous system (CNS axon regeneration results in devastating consequences and poor functional recovery. The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons. The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury. In the CNS, many of the signalling pathways associated with neuronal survival and axon regeneration are regulated by several classes of receptor tyrosine kinases (RTK that respond to a variety of ligands. This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration.

  12. SnoN facilitates axonal regeneration after spinal cord injury.

    Directory of Open Access Journals (Sweden)

    Jiun L Do

    Full Text Available Adult CNS neurons exhibit a reduced capacity for growth compared to developing neurons, due in part to downregulation of growth-associated genes as development is completed. We tested the hypothesis that SnoN, an embryonically regulated transcription factor that specifies growth of the axonal compartment, can enhance growth in injured adult neurons. In vitro, SnoN overexpression in dissociated adult DRG neuronal cultures significantly enhanced neurite outgrowth. Moreover, TGF-β1, a negative regulator of SnoN, inhibited neurite outgrowth, and SnoN over-expression overcame this inhibition. We then examined whether SnoN influenced axonal regeneration in vivo: indeed, expression of a mutant form of SnoN resistant to degradation significantly enhanced axonal regeneration following cervical spinal cord injury, despite peri-lesional upregulation of TGF-β1. Thus, a developmental mechanism that specifies extension of the axonal compartment also promotes axonal regeneration after adult CNS injury.

  13. Brain injury tolerance limit based on computation of axonal strain.

    Science.gov (United States)

    Sahoo, Debasis; Deck, Caroline; Willinger, Rémy

    2016-07-01

    Traumatic brain injury (TBI) is the leading cause of death and permanent impairment over the last decades. In both the severe and mild TBIs, diffuse axonal injury (DAI) is the most common pathology and leads to axonal degeneration. Computation of axonal strain by using finite element head model in numerical simulation can enlighten the DAI mechanism and help to establish advanced head injury criteria. The main objective of this study is to develop a brain injury criterion based on computation of axonal strain. To achieve the objective a state-of-the-art finite element head model with enhanced brain and skull material laws, was used for numerical computation of real world head trauma. The implementation of new medical imaging data such as, fractional anisotropy and axonal fiber orientation from Diffusion Tensor Imaging (DTI) of 12 healthy patients into the finite element brain model was performed to improve the brain constitutive material law with more efficient heterogeneous anisotropic visco hyper-elastic material law. The brain behavior has been validated in terms of brain deformation against Hardy et al. (2001), Hardy et al. (2007), and in terms of brain pressure against Nahum et al. (1977) and Trosseille et al. (1992) experiments. Verification of model stability has been conducted as well. Further, 109 well-documented TBI cases were simulated and axonal strain computed to derive brain injury tolerance curve. Based on an in-depth statistical analysis of different intra-cerebral parameters (brain axonal strain rate, axonal strain, first principal strain, Von Mises strain, first principal stress, Von Mises stress, CSDM (0.10), CSDM (0.15) and CSDM (0.25)), it was shown that axonal strain was the most appropriate candidate parameter to predict DAI. The proposed brain injury tolerance limit for a 50% risk of DAI has been established at 14.65% of axonal strain. This study provides a key step for a realistic novel injury metric for DAI. PMID:27038501

  14. 4S RNA is transported axonally in normal and regenerating axons of the sciatic nerves of rats

    International Nuclear Information System (INIS)

    Experiments were designed to determine if following injection of [3H]uridine into the lumbar spinal cord of the rat, [3H]RNA could be demonstrated within axons of the sciatic nerve, and if 4S RNA is the predominant predominant RNA species present in these axons. (Auth.)

  15. Large probe arrays for measuring mean and time dependent local oil volume fraction and local oil velocity component distributions in inclined oil-in-water flows

    OpenAIRE

    Lucas, Gary; Zhao, X.

    2013-01-01

    Arrays of dual-sensor and four-sensor needle conductance probes have been used to measure the mean and time dependent local properties of upward inclined, bubbly oil-in-water flows (also known as dispersed oil-in-water flows) in a 153mm diameter pipe. The flow properties that were measured were (i) the local in-situ oil volume fraction ; (ii) the local oil velocity in the axial direction of the pipe (the direction); and (iii) the local oil velocity in the direction from the lower side ...

  16. Standard logarithmic mean velocity distribution in a band-limited restricted nonlinear model of turbulent flow in a half-channel

    CERN Document Server

    Bretheim, Joel U; Gayme, Dennice F

    2014-01-01

    Numerical simulations of wall-turbulence using the restricted nonlinear (RNL) model generate realistic mean velocity profiles in plane Couette and channel flow at low Reynolds numbers. The results are less accurate at higher Re, and while a logarithmic region is observed, its von-K\\'arm\\'an constant is not consistent with the standard logarithmic law. In half-channel flow we show that limiting the streamwise-varying wavenumber support of RNL turbulence to one or few empirically determined modes improves its predictions considerably. In particular, the mean velocity profiles obtained with the band-limited RNL model follow standard logarithmic behavior for the higher Reynolds numbers in this study.

  17. Laboratory study of 3D velocity distribution of P and S wawes in rocks: comparison of high pressure study and texture based calculated data

    Czech Academy of Sciences Publication Activity Database

    Lokajíček, Tomáš; Svitek, Tomáš; Ivankina, T.; Kern, H.

    Montréal: Canadian Institute of Mining , Metallurgy and Petroleum, 2015. ISBN 978-1-926872-25-4. [International Congress of Rock Mechanics /13./. Montréal (CA), 10.05.2015-13.05.2015] R&D Projects: GA ČR(CZ) GAP104/12/0915; GA ČR GA13-13967S; GA MŠk LH13102 Institutional support: RVO:67985831 Keywords : velocity measurements * 3D-velocity calculation * neutron diffraction * seismic anisotropy * measured and calculated elastic properties Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  18. Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination

    Institute of Scientific and Technical Information of China (English)

    Boting Gao; Juan Chen; Qiong Wang; Wei Wang; Zhouping Tang

    2011-01-01

    The present study established a chronic experimental autoimmune encephalomyelitis model in C57BL/6 mice induced by myelin oligodendrocyte glycoprotein peptides and complete Freund's adjuvant. Onset latency was 12 days, with an incidence rate of 100%. Neuropathological characteristics included perivascular inflammatory cell infiltration, demyelination, neuronal degeneration, and axonal damage within cerebral and myelic white matter. Electron microscopy revealed swollen mitochondria, complete organ disappearance, and fused or broken myelin sheath structure, which were accompanied by myelin sheath reconstruction. Moreover, axonal damage was not consistent with demyelination distribution, and severity of axonal damage did not correlate with demyelination. Results suggested that axonal damage in an experimental autoimmune encephalomyelitis model is not secondary to inflammatory demyelination.

  19. Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development.

    Science.gov (United States)

    Gauron, Carole; Meda, Francesca; Dupont, Edmond; Albadri, Shahad; Quenech'Du, Nicole; Ipendey, Eliane; Volovitch, Michel; Del Bene, Filippo; Joliot, Alain; Rampon, Christine; Vriz, Sophie

    2016-06-15

    It is now becoming evident that hydrogen peroxide (H2O2), which is constantly produced by nearly all cells, contributes to bona fide physiological processes. However, little is known regarding the distribution and functions of H2O2 during embryonic development. To address this question, we used a dedicated genetic sensor and revealed a highly dynamic spatio-temporal pattern of H2O2 levels during zebrafish morphogenesis. The highest H2O2 levels are observed during somitogenesis and organogenesis, and these levels gradually decrease in the mature tissues. Biochemical and pharmacological approaches revealed that H2O2 distribution is mainly controlled by its enzymatic degradation. Here we show that H2O2 is enriched in different regions of the developing brain and demonstrate that it participates to axonal guidance. Retinal ganglion cell axonal projections are impaired upon H2O2 depletion and this defect is rescued by H2O2 or ectopic activation of the Hedgehog pathway. We further show that ex vivo, H2O2 directly modifies Hedgehog secretion. We propose that physiological levels of H2O2 regulate RGCs axonal growth through the modulation of Hedgehog pathway. PMID:27158028

  20. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

    Czech Academy of Sciences Publication Activity Database

    Balaštík, Martin; Zhou, X.Z.; Alberich-Jorda, Meritxell; Weissová, Romana; Žiak, Jakub; Pazyra-Murphy, M.F.; Cosker, K.E.; Machoňová, Olga; Kozmiková, Iryna; Chen, CH.; Pastorino, L.; Asara, J.M.; Cole, A.; Sutherland, C.; Segal, R. A.; Lu, K.P.

    2015-01-01

    Roč. 13, č. 4 (2015), s. 812-828. ISSN 2211-1247 R&D Projects: GA MŠk(CZ) LK11213; GA MŠk LK21307; GA ČR GA15-03796S; GA MŠk LO1419 Institutional support: RVO:68378050 Keywords : Pin1 * axon guidance * Semaphorin 3A Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 8.358, year: 2014

  1. Clinical features of diffuse axonal injury

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To analyze the mechanism of diffuse axonal injury (DAI) and study the relationship between DAI and brain concussion, brain contusion, and primary brain stem injury.Methods: The clinical data and iconographic characteristics of 56 patients with DAI were analyzed retrospectively.Results: Traffic accidents were the main cause of DAI. Among the 56 cases, 34 were injured for at least twice, and 71.43% of the patients were complicated with contusion.Conclusions: It is considered that DAI is a common pattern of primary brain injury, which is often underestimated. And DAI includes cerebral concussion and primary brain injury, and is often complicated by cerebral cortex contusion. Therefore, it is very simple and practical to divide primary brain injuries into local and diffuse injuries.

  2. Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons

    Directory of Open Access Journals (Sweden)

    Karen Chang

    2013-09-01

    Full Text Available Neurons are extremely polarized structures with long axons and dendrites, which require proper distribution of mitochondria and maintenance of mitochondrial dynamics for neuronal functions and survival. Indeed, recent studies show that various neurological disorders are linked to mitochondrial transport in neurons. Mitochondrial anterograde transport is believed to deliver metabolic energy to synaptic terminals where energy demands are high, while mitochondrial retrograde transport is required to repair or remove damaged mitochondria in axons. It has been suggested that Ca2+ plays a key role in regulating mitochondrial transport by altering the configuration of mitochondrial protein, miro. However, molecular mechanisms that regulate mitochondrial transport in neurons still are not well characterized. In this review, we will discuss the roles of miro in mitochondrial transport and how the recently identified components of the mitochondrial calcium uniporter add to our current model of mitochondrial mobility regulation.

  3. Effect of transition in cross-sectional shape on the development of the velocity and pressure distribution of turbulent flow in pipes

    Science.gov (United States)

    Mayer, Edwin

    1939-01-01

    With regard to the change in shape of the cross section while the area remains constant, no investigation results are as yet available. Such an investigation will be the subject of the present paper. For this purpose it is necessary to consider the velocity and pressure relations over each entire cross section so that we are confronted with a three-dimensional problem.

  4. Angular and velocity distributions of the HD sup + and D sub 2 sup + fragments from HD sub 2 sup + colliding with He at energies of 1 to 5 keV

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, I.; Martriaanez, H.; Cisneros, C.; de Urquijo, J. (Instituto de Fisica, Universidad Nacional Autonoma de Mexico, P.O. Box 139-B, 62191 Cuernavaca Morelos (Mexico))

    1992-01-01

    The angular and velocity distributions of the HD{sup +} and D{sub 2}{sup +} fragments resulting from collision-induced dissociation of the HD{sub 2}{sup +} molecular ion incident on He have been measured in the energy range 1--5 keV. These distributions were used to determine the binding energy of HD{sub 2}{sup +}, some of the main transitions involved in the dissociation process, and the total cross sections for the production of both fragments.

  5. Membrane turnover and receptor trafficking in regenerating axons.

    Science.gov (United States)

    Hausott, Barbara; Klimaschewski, Lars

    2016-02-01

    Peripheral axonal regeneration requires surface-expanding membrane addition. The continuous incorporation of new membranes into the axolemma allows the pushing force of elongating microtubules to drive axonal growth cones forwards. Hence, a constant supply of membranes and cytoskeletal building blocks is required, often for many weeks. In human peripheral nerves, axonal tips may be more than 1 m away from the neuronal cell body. Therefore, in the initial phase of regeneration, membranes are derived from pre-existing vesicles or synthesised locally. Only later stages of axonal regeneration are supported by membranes and proteins synthesised in neuronal cell bodies, considering that the fastest anterograde transport mechanisms deliver cargo at 20 cm/day. Whereas endocytosis and exocytosis of membrane vesicles are balanced in intact axons, membrane incorporation exceeds membrane retrieval during regeneration to compensate for the loss of membranes distal to the lesion site. Physiological membrane turnover rates will not be established before the completion of target reinnervation. In this review, the current knowledge on membrane traffic in axonal outgrowth is summarised, with a focus on endosomal vesicles as the providers of membranes and carriers of growth factor receptors required for initiating signalling pathways to promote the elongation and branching of regenerating axons in lesioned peripheral nerves. PMID:26222895

  6. Astrocyte scar formation aids central nervous system axon regeneration.

    Science.gov (United States)

    Anderson, Mark A; Burda, Joshua E; Ren, Yilong; Ao, Yan; O'Shea, Timothy M; Kawaguchi, Riki; Coppola, Giovanni; Khakh, Baljit S; Deming, Timothy J; Sofroniew, Michael V

    2016-04-14

    Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous regrowth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (SCI) lesions. By contrast, sustained local delivery via hydrogel depots of required axon-specific growth factors not present in SCI lesions, plus growth-activating priming injuries, stimulated robust, laminin-dependent sensory axon regrowth past scar-forming astrocytes and inhibitory molecules in SCI lesions. Preventing astrocytic scar formation significantly reduced this stimulated axon regrowth. RNA sequencing revealed that astrocytes and non-astrocyte cells in SCI lesions express multiple axon-growth-supporting molecules. Our findings show that contrary to the prevailing dogma, astrocyte scar formation aids rather than prevents central nervous system axon regeneration. PMID:27027288

  7. Intra-axonal myosin and actin in nerve regeneration.

    Science.gov (United States)

    McQuarrie, Irvine G; Lund, Linda M

    2009-10-01

    A focused review of sciatic nerve regeneration in the rat model, based on research conducted by the authors, is presented. We examine structural proteins carried distally in the axon by energy-requiring motor enzymes, using protein chemistry and molecular biology techniques in combination with immunohistochemistry. Relevant findings from other laboratories are cited and discussed. The general conclusion is that relatively large amounts of actin and tubulin are required to construct a regenerating axon and that these materials mainly originate in the parent axon. The motor enzymes that carry these proteins forward as macromolecules include kinesin and dynein but probably also include myosin. PMID:19927086

  8. Axon guidance and neuronal migration research in China

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Proper migration of neuronal somas and axonal growth cones to designated locations in the developing brain is essential for the assembly of functional neuronal circuits.Rapid progress in research of axon guidance and neuronal migration has been made in the last twenty years.Chinese researchers began their exploration in this field ten years ago and have made significant contributions in clarifying the signal transduction of axon guidance and neuronal migration.Several unique experimental approaches,including the migration assay of single isolated neurons in response to locally delivered guidance cues,have been developed by Chinese neuroscientists to investigate the molecular machinery underlying these guidance events.

  9. On corrections to spectroscopically measured Franck-Condon energies arising from motion of the parent molecules and from ion collisions in fusion plasmas: relevant time scales for atomic velocity distributions

    International Nuclear Information System (INIS)

    We show that while corrections to spectroscopically measured Franck-Condon energies, arising from motion of the parent molecules at the edge of fusion plasmas, are insignificant in many practical cases, ion collisions play an important role in randomizing and redistributing the velocities of the atomic products of molecular dissociation. Formulae are obtained from which the time scales for randomization and equilibration of the atomic velocity distribution may be estimated, and hence compared with characteristic times for other important atomic processes. Examples of the latter are: spontaneous emission, production of atoms by electron impact-induced dissociation and ionization of molecules, electron collisions of the first and second kinds, charge-exchange recombination and electron impact ionization. We show that the time scales of randomization and equilibration can be comparable with those for some of the other processes listed above, but are much longer than typical times for spontaneous emission. The ion-atom collisional processes considered here therefore affect the atomic velocity distribution mainly after the atoms produced directly by molecular dissociation have arrived in their ground states. The formulae derived for these collisional time scales may well be useful in modelling hydrogen transport and recycling in fusion plasmas

  10. Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration.

    Science.gov (United States)

    Dingyu, Wang; Fanjie, Meng; Zhengzheng, Ding; Baosheng, Huang; Chao, Yang; Yi, Pan; Huiwen, Wu; Jun, Guo; Gang, Hu

    2016-09-01

    Intracellular tension is the most important characteristic of neuron polarization as well as the growth and regeneration of axons, which can be generated by motor proteins and conducted along the cytoskeleton. To better understand this process, we created Förster resonance energy transfer (FRET)-based tension probes that can be incorporated into microfilaments to provide a real-time measurement of forces in neuron cytoskeletons. We found that our probe could be used to assess the structural tension of neuron polarity. Nerve growth factor (NGF) upregulated structural forces, whereas the glial-scar inhibitors chondroitin sulfate proteoglycan (CSPG) and aggrecan weakened such forces. Notably, the tension across axons was distributed uniformly and remarkably stronger than that in the cell body in NGF-stimulated neurons. The mechanosensors talin/vinculin could antagonize the effect of glial-scar inhibitors via structural forces. However, E-cadherin was closely associated with glial-scar inhibitor-induced downregulation of structural forces. Talin/vinculin was involved in the negative regulation of E-cadherin transcription through the nuclear factor-kappa B pathway. Collectively, this study clarified the mechanism underlying intracellular tension in the growth and regeneration of axons which, conversely, can be regulated by talin and E-cadherin. PMID:26298665

  11. Genetics Home Reference: autosomal recessive axonal neuropathy with neuromyotonia

    Science.gov (United States)

    ... neuromyotonia is a disorder that affects the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles ... caused by damage to a particular part of peripheral nerves called axons , which are the extensions of nerve ...

  12. Internodal function in normal and regenerated mammalian axons

    DEFF Research Database (Denmark)

    Moldovan, M; Krarup, C

    2007-01-01

    AIM: Following Wallerian degeneration, peripheral myelinated axons have the ability to regenerate and, given a proper pathway, establish functional connections with targets. In spite of this capacity, the clinical outcome of nerve regeneration remains unsatisfactory. Early studies have found that...

  13. Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration

    Directory of Open Access Journals (Sweden)

    Tyson J. Edwards

    2014-07-01

    Full Text Available Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS proteoglycan, is required for growth cone function during axon regeneration in C. elegans. In the absence of syndecan, regenerating growth cones form but are unstable and collapse, decreasing the effective growth rate and impeding regrowth to target cells. We provide evidence that syndecan has two distinct functions during axon regeneration: (1 a canonical function in axon guidance that requires expression outside the nervous system and depends on HS chains and (2 an intrinsic function in growth cone stabilization that is mediated by the syndecan core protein, independently of HS. Thus, syndecan is a regulator of a critical choke point in nervous system repair.

  14. Saltatory conduction in unmyelinated axons: Clustering of Na+ channels on lipid rafts allows micro-saltatory conduction in C-fibers

    Directory of Open Access Journals (Sweden)

    Ali eNeishabouri

    2014-10-01

    Full Text Available The action potential (AP, the fundamental signal of the nervous system, is carried by two types of axons: unmyelinated and myelinated fibers. In the former the action potential propagates continuously along the axon as established in large-diameter fibers. In the latter axons the AP jumps along the Nodes of Ranvier – discrete, anatomically specialized regions which contain very high densities of sodium ion (Na + channels. Therefore saltatory conduction is thought as the hallmark of myelinated axons, which enables faster and more reliable propagation of signals than in unmyelinated axons of same outer diameter.Recent molecular anatomy showed that in C-fibers, the very thin (0.1 μm diameter axons of the peripheral nervous system, Nav1.8 channels are clustered together on lipid rafts that float in the cell membrane. This localized concentration of Na+ channels resembles in structure the ion channel organization at the Nodes of Ranvier, yet it is currently unknown whether this translates into equivalent phenomenon of saltatory conduction or related-functional benefits and efficiencies. Therefore, we modeled biophysically realistic unmyelinated axons with both conventional and lipid-raft based organization of Na+ channels. We find that action potentials are reliably conducted in a micro-saltatory fashion along lipid rafts.Comparing APs in unmyelinated fibers with and without lipid rafts did not reveal any significant difference in either the metabolic cost or AP propagation velocity. By investigating the efficiency of AP propagation over Nav1.8 channels, we find however that the specific inactivation properties of these channels significantly increase the metabolic cost of signaling in C-fibers.

  15. Alteration of neural action potential patterns by axonal stimulation: the importance of stimulus location

    Science.gov (United States)

    Crago, Patrick E.; Makowski, Nathaniel S.

    2014-10-01

    Objective. Stimulation of peripheral nerves is often superimposed on ongoing motor and sensory activity in the same axons, without a quantitative model of the net action potential train at the axon endpoint. Approach. We develop a model of action potential patterns elicited by superimposing constant frequency axonal stimulation on the action potentials arriving from a physiologically activated neural source. The model includes interactions due to collision block, resetting of the neural impulse generator, and the refractory period of the axon at the point of stimulation. Main results. Both the mean endpoint firing rate and the probability distribution of the action potential firing periods depend strongly on the relative firing rates of the two sources and the intersite conduction time between them. When the stimulus rate exceeds the neural rate, neural action potentials do not reach the endpoint and the rate of endpoint action potentials is the same as the stimulus rate, regardless of the intersite conduction time. However, when the stimulus rate is less than the neural rate, and the intersite conduction time is short, the two rates partially sum. Increases in stimulus rate produce non-monotonic increases in endpoint rate and continuously increasing block of neurally generated action potentials. Rate summation is reduced and more neural action potentials are blocked as the intersite conduction time increases. At long intersite conduction times, the endpoint rate simplifies to being the maximum of either the neural or the stimulus rate. Significance. This study highlights the potential of increasing the endpoint action potential rate and preserving neural information transmission by low rate stimulation with short intersite conduction times. Intersite conduction times can be decreased with proximal stimulation sites for muscles and distal stimulation sites for sensory endings. The model provides a basis for optimizing experiments and designing neuroprosthetic

  16. Pontine reticulospinal projections in the neonatal mouse: Internal organization and axon trajectories.

    Science.gov (United States)

    Sivertsen, Magne S; Perreault, Marie-Claude; Glover, Joel C

    2016-04-15

    We recently characterized physiologically a pontine reticulospinal (pRS) projection in the neonatal mouse that mediates synaptic effects on spinal motoneurons via parallel uncrossed and crossed pathways (Sivertsen et al. [2014] J Neurophysiol 112:1628-1643). Here we characterize the origins, anatomical organization, and supraspinal axon trajectories of these pathways via retrograde tracing from the high cervical spinal cord. The two pathways derive from segregated populations of ipsilaterally and contralaterally projecting pRS neurons with characteristic locations within the pontine reticular formation (PRF). We obtained estimates of relative neuron numbers by counting from sections, digitally generated neuron position maps, and 3D reconstructions. Ipsilateral pRS neurons outnumber contralateral pRS neurons by threefold and are distributed about equally in rostral and caudal regions of the PRF, whereas contralateral pRS neurons are concentrated in the rostral PRF. Ipsilateral pRS neuron somata are on average larger than contralateral. No pRS neurons are positive in transgenic mice that report the expression of GAD, suggesting that they are predominantly excitatory. Putative GABAergic interneurons are interspersed among the pRS neurons, however. Ipsilateral and contralateral pRS axons have distinctly different trajectories within the brainstem. Their initial spinal funicular trajectories also differ, with ipsilateral and contralateral pRS axons more highly concentrated medially and laterally, respectively. The larger size and greater number of ipsilateral vs. contralateral pRS neurons is compatible with our previous finding that the uncrossed projection transmits more reliably to spinal motoneurons. The information about supraspinal and initial spinal pRS axon trajectories should facilitate future physiological assessment of synaptic connections between pRS neurons and spinal neurons. J. Comp. Neurol. 524:1270-1291, 2016. © 2015 Wiley Periodicals, Inc. PMID

  17. Treadmill Training Promotes Axon Regeneration in Injured Peripheral Nerves

    OpenAIRE

    Sabatier, Manning J.; Redmon, Natalie; Schwartz, Gail; English, Arthur W.

    2008-01-01

    Physical activity after spinal cord injury promotes improvements in motor function, but its effects following peripheral nerve injury are less clear. Although axons in peripheral nerves are known to regenerate better than those in the CNS, methods of accelerating regeneration are needed due to the slow overall rate of growth. Therefore we studied the effect of two weeks of treadmill locomotion on the growth of regenerating axons in peripheral nerves following injury. The common fibular nerves...

  18. Fcγ receptor-mediated inflammation inhibits axon regeneration.

    Directory of Open Access Journals (Sweden)

    Gang Zhang

    Full Text Available Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy. We previously reported that disease-relevant anti-glycan autoantibodies inhibited axon regeneration, which echo the clinical association of these antibodies and poor recovery in Guillain-Barré Syndrome. However, the specific molecular and cellular elements involved in this antibody-mediated inhibition of axon regeneration are not previously defined. This study examined the role of Fcγ receptors and macrophages in the antibody-mediated inhibition of axon regeneration. A well characterized antibody passive transfer sciatic nerve crush and transplant models were used to study the anti-ganglioside antibody-mediated inhibition of axon regeneration in wild type and various mutant and transgenic mice with altered expression of specific Fcγ receptors and macrophage/microglia populations. Outcome measures included behavior, electrophysiology, morphometry, immunocytochemistry, quantitative real-time PCR, and western blotting. We demonstrate that the presence of autoantibodies, directed against neuronal/axonal cell surface gangliosides, in the injured mammalian peripheral nerves switch the proregenerative inflammatory environment to growth inhibitory milieu by engaging specific activating Fcγ receptors on recruited monocyte-derived macrophages to cause severe inhibition of axon regeneration. Our data demonstrate that the antibody orchestrated Fcγ receptor-mediated switch in inflammation is one mechanism underlying inhibition of axon regeneration. These findings have clinical implications for nerve repair and recovery in antibody-mediated immune neuropathies. Our results add to the complexity of axon regeneration in injured peripheral and central nervous systems as adverse effects of B cells and autoantibodies on neural injury and repair are increasingly recognized.

  19. Modality-Specific Axonal Regeneration: Towards selective regenerative neural interfaces

    Directory of Open Access Journals (Sweden)

    Mario I Romero

    2011-10-01

    Full Text Available Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed submodality types, which difficult the specific recording from motor axons and the eliciting of precise sensory modalities through selective stimulation. Here we evaluated the possibility of using type-specific neurotrophins to preferentially entice the regeneration of defined axonal populations from transected peripheral nerves into separate compartments. Segregation of mixed sensory fibers from dorsal root ganglion neurons was evaluated in vitro by compartmentalized diffusion delivery of nerve growth factor (NGF and neurotrophin-3 (NT-3, to preferentially entice the growth of TrkA+ nociceptive and TrkC+ proprioceptive subsets of sensory neurons, respectively. The average axon length in the NGF channel increased 2.5 fold compared to that in saline or NT-3, whereas the number of branches increased 3 fold in the NT-3 channels. These results were confirmed using a 3-D “Y”-shaped in vitro assay showing that the arm containing NGF was able to entice a 5-fold increase in axonal length of unbranched fibers. To address if such segregation can be enticed in vivo, a “Y”-shaped tubing was used to allow regeneration of the transected adult rat sciatic nerve into separate compartments filled with either NFG or NT-3. A significant increase in the number of CGRP+ pain fibers were attracted towards the sural nerve, while N-52+ large diameter axons were observed in the tibial and NT-3 compartments. This study demonstrates the guided enrichment of sensory axons in specific regenerative chambers, and supports the notion that neurotrophic factors can be used to segregate sensory and perhaps motor axons in separate peripheral interfaces.

  20. Axonal integrity predicts cortical reorganisation following cervical injury

    OpenAIRE

    Freund, P.; Wheeler-Kingshott, C.A.; Nagy, Z.; Gorgoraptis, N.; N. Weiskopf; Friston, K.; Thompson, A J; Hutton, C.

    2012-01-01

    Background Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord—the presumed basis of ensuing clinical impairment. Objective The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish how microstructural white matter changes in the CST are related to cross-sectional spinal cord area a...

  1. Axonal neuropathy associated with monoclonal gammopathy of undetermined significance

    OpenAIRE

    GORSON, K.; Ropper, A.

    1997-01-01

    OBJECTIVE—The neuropathy associated with monoclonal gammopathy of undetermined significance (MGUS) is typically a predominantly demyelinating process that may have additional features of axonal degeneration. Sixteen patients with MGUS and a pure or predominantly axonal neuropathy are reported and compared with 20 consecutive patients with demyelinating neuropathy and MGUS who were seen during the same period.
METHODS—Retrospective review of a consecutive series of patients w...

  2. Changes in prefrontal axons may disrupt the network in autism

    OpenAIRE

    Zikopoulos, Basilis; Barbas, Helen

    2010-01-01

    Neural communication is disrupted in autism by unknown mechanisms. Here we examined whether in autism there are changes in axons, which are the conduit for neural communication. We investigated single axons and their ultrastructure in the white matter of post-mortem human brain tissue below the anterior cingulate cortex (ACC), orbitofrontal (OFC), and lateral (LPFC) prefrontal cortices, which are associated with attention, social interactions, and emotions and have been consistently implicate...

  3. Axonal maintenance, glia, exosomes, and heat shock proteins

    OpenAIRE

    Michael Tytell; Lasek, Raymond J.; Harold Gainer

    2016-01-01

    Of all cellular specializations, the axon is especially distinctive because it is a narrow cylinder of specialized cytoplasm called axoplasm with a length that may be orders of magnitude greater than the diameter of the cell body from which it originates. Thus, the volume of axoplasm can be much greater than the cytoplasm in the cell body. This fact raises a logistical problem with regard to axonal maintenance. Many of the components of axoplasm, such as soluble proteins and cytoskeleton, are...

  4. Electrical Potential, Mass Transport and Velocity Distribution of Electro-osmotic Flow in a Nanochannel by Incorporating the Variation of Dielectric Constant of Aqueous Electrolyte Solution

    CERN Document Server

    Padidhapu, Rajendra; Brahmajirao, V

    2016-01-01

    We consider a coupled system of Navier Stokes, Maxwell Stefan and Poisson Boltzmann equations by incorporating the variation of dielectric constant, which governs the electro osmotic flow in nano channel, describing the evolution of the velocity, concentration and potential fields of dissolved constituents in an aqueous electrolyte solution. We apply the finite difference technique to solve one and two dimensional systems of these equations. The solutions give an extremely accurate prediction of the dielectric constant for a variety of salts and a wide range of concentrations.

  5. THEORETICAL PRINCIPLES UNDERLYING OPTICAL STIMULATION OF MYELINATED AXONS EXPRESSING CHANNELRHODOPSIN-2

    OpenAIRE

    ARLOW, R. L.; FOUTZ, T. J.; MCINTYRE, C. C.

    2013-01-01

    Numerous clinical conditions can be treated by neuromodulation of the peripheral nervous system (PNS). Typical electrical PNS therapies activate large diameter axons at lower electrical stimulus thresholds than small diameter axons. However, recent animal experiments with peripheral optogenetic neural stimulation (PONS) of myelinated axons expressing channelrhodopsin-2 (ChR2) have shown that this technique activates small diameter axons at lower irradiances than large diameter axons. We hypot...

  6. Spinal irradiation does not inhibit distal axonal sprouting

    International Nuclear Information System (INIS)

    In an attempt to determine the relative importance of the nerve cell body and of the axon in initiating and controlling axonal regeneration, nerve cell bodies were irradiated and the ability of the distal axon to sprout was examined. Mice were subjected to either 25 or 50 Gray (Gy) of x-irradiation localized to the lumbar spinal cord. After times varying from 1 day to 6 months after irradiation, a sublethal dose of botulinum toxin (BoTx) was injected into the calf muscles of one leg. The soleus muscle was examined histologically after times varying from 1 week to 6 months after injection, and BoTx-induced ultraterminal axonal sprouting was assessed by the number of motor endplates showing sprouts, the length of the sprouts, and the long term endplate morphology. Apart from some irradiated subgroups having slightly shorter sprout lengths, no significant differences were found between irradiated and nonirradiated groups. The results suggest either that the processes in the nerve cell body responsible for initiating and supporting axonal growth are resistant to large doses of irradiation, or that growth regulatory mechanisms in the distal axon are under local control

  7. Dynamics of signal propagation and collision in axons

    Science.gov (United States)

    Follmann, Rosangela; Rosa, Epaminondas; Stein, Wolfgang

    2015-09-01

    Long-range communication in the nervous system is usually carried out with the propagation of action potentials along the axon of nerve cells. While typically thought of as being unidirectional, it is not uncommon for axonal propagation of action potentials to happen in both directions. This is the case because action potentials can be initiated at multiple "ectopic" positions along the axon. Two ectopic action potentials generated at distinct sites, and traveling toward each other, will collide. As neuronal information is encoded in the frequency of action potentials, action potential collision and annihilation may affect the way in which neuronal information is received, processed, and transmitted. We investigate action potential propagation and collision using an axonal multicompartment model based on the Hodgkin-Huxley equations. We characterize propagation speed, refractory period, excitability, and action potential collision for slow (type I) and fast (type II) axons. In addition, our studies include experimental measurements of action potential propagation in axons of two biological systems. Both computational and experimental results unequivocally indicate that colliding action potentials do not pass each other; they are reciprocally annihilated.

  8. Ultrastructural observation of effect of moderate hypothermia on axonal damage in an animal model of diffuse axonal injury

    Institute of Scientific and Technical Information of China (English)

    孙晓川; 唐文渊; 郑履平

    2002-01-01

    Objective: To investigate the effect of moderate hypothermia on responses of axonal cytoskeleton to axonal injury in the acute stage of injury. Methods: Of fifteen adult guinea pigs, twelve animals were subjected to stretch injury to the right optic nerves and divided into the normothermic group (n=6) in which the animal's core temperature was maintained at 36.0-37.5℃ and the hypothermia group (n=6) in which the core temperature was reduced to 32.0-32.5℃ after stretch injury. Remaining three animals sustained no injury to the right optic nerves and served as control group. Half of injured animals (n=3) of either normothermic group or hypothermic group were killed at either 2 hours or 4 hours after injury. The ultrastructural changes of axonal cytoskeleton of the right optic nerve fibers from the animals were examined under a transmission electron microscope and analyzed by quantitative analysis with a computer image analysis system. Results: At 2 hours after stretch injury, there was a significant reduction in the mean number of microtubules (P<0.001), and a significant increase in the mean intermicrotubule spacing (P<0.05 or P<0.01) in axons of all sizes in normothermic animals. The mean number of neurofilaments also decreased statistically (P<0.01) in large and medium subgroups of axons in the same experimental group at 2 hours. By 4 hours, the large subgroup of axons in normothermic animals still demonstrated a significant decline in the mean number of microtubules (P<0.01) and an increase in the mean intermicrotubule spacing (P<0.05), while the medium and small subgroups of axons displayed a significant increase in the mean number of neurofilaments (P<0.05) and reduction in the mean interneurofilament spacing (P<0.05). On the contrary, either the mean number of microtubules and the mean intermicrotubule spacing, or the mean number of neurofilaments and interneurofilament spacing in axons of all sizes in hypothermic stretch-injured animals was not

  9. 多级鼓泡塔内液体速度分布的实验研究%Experimental study on liquid velocity distribution in multi-stage bubble column

    Institute of Scientific and Technical Information of China (English)

    樊亚超; 靳海波; 秦岭; 杨索和; 何广湘

    2011-01-01

    液体循环流动是多级鼓泡塔重要流体力学特征之一,文中在内径为282 mm,高2000 mm的鼓泡塔内,采用不同类型的筛板将普通鼓泡塔分割成双级气液鼓泡塔.采用Pavlov管测液速的方法考察了不同筛板、不同表观气速下该鼓泡塔中上下二侧的液体速度分布.根据实验结果得出了液体速度在塔中心处最大,且与表观气速有关,随着表观气速的增大而增大;气液鼓泡塔内液速分布呈半抛物线状,在量纲一径向位置0.7左右处,液体速度方向发生改变;加入筛板后,径向速度区发生改变,转折点的位置与筛板的类型有关;同时筛板的加入对鼓泡塔的湍流会有一定程度的抑制,筛板对鼓泡塔上侧液速径向分布的影响明显大于对鼓泡塔下侧液速径向分布的影响.%The characteristic of liquid circulation flow is an important feature of hydrodynamics in multi-stage bubble columns. A bubble column of 282 mm in diameter and 2000 mm in height was selected, and various kinds of sieve plates were introduced to divide a conventional gas-liquid column into a two-stage gas-liquid bubble column. The effects of sieve plate and superficial gas velocity on the liquid velocity distribution in the upper and the lower of the multi-stage gas-liquid bubble column were studied by the method of Pavlov tube. The experimental results show that the maximum liquid velocity appears in the center of the bubble column, and increases with an increase of superficial gas velocity. The curves of liquid velocity distribution are half-parabolic in a gas-liquid bubble column, and liquid velocity direction is changed at around 0. 7 of dimensional-one radial direction. Meanwhile, the introduction of sieve plate suppresses the liquid turbulent flow, and affects the inversion point of liquid velocity. Moreover, the value of inversion point changes with the difference of sieve plate structure. The radial distribution of liquid velocity on the

  10. Sap-flow velocities and distribution of wet-wood in trunks of healthy and unhealthy Quercus robur, Quercus petraea and Quercus cerris oak trees in Hungary

    International Nuclear Information System (INIS)

    Sap-flow of Quercus robur, Quercus petraea and Quercus cerris oak trees were studied. 43K radioisotope tracing, the heat pulse velocity technique and the Granier-method were employed. Numerous intense pulses were observed in healthy Quercus petraea superposing onto the usual diurnal change. Only a few pulses were observed in unhealthy Quercus petraea, in healthy Quercus cerris and healthy and unhealthy Quercus robur trees. Proportion of wet-wood assessed by γ- and X-ray computer tomography and magnetic resonance imaging was significantly less in healthy Quercus petraea trees than in healthy Quercus cerris trees. Proportion of wet-wood was higher in healthy trees than unhealthy trees of both species. (author)

  11. Dogs with hearth diseases causing turbulent high-velocity blood flow have changes in patelet function and von Willebrand factor multimer distribution

    DEFF Research Database (Denmark)

    Tarnow, Inge; Kristensen, Annemarie Thuri; Olsen, Lisbeth Høier; Falk, Bo Torkel; Haubro, Lotte; Pedersen, Lotte Gam; Pedersen, Henrik Duelund

    2005-01-01

    echocardiography were performed in all dogs. PFA100 closure times (the ability of platelets to occlude a hole in a membrane at high shear rates), platelet activation markers (plasma thromboxane B2 concentration, platelet surface P-selectin expression), platelet aggregation (in whole blood and platelet-rich plasma......The purpose of this prospective study was to investigate platelet function using in vitro tests based on both high and low shear rates and von Willebrand factor (vWf) multimeric composition in dogs with cardiac disease and turbulent high-velocity blood flow. Client-owned asymptomatic, untreated...... with 3 different agonists), and vWf multimers were analyzed. Cavaliers with moderate to severe MR and dogs with SAS had longer closure times and a lower percentage of the largest vWf multimers than did controls. Maximal aggregation responses were unchanged in dogs with SAS but enhaned in Cavaliers with...

  12. Potential Involvement of Draxin in the Axonal Projection of Cranial Nerves, Especially Cranial Nerve X, in the Chick Hindbrain.

    Science.gov (United States)

    Zhang, Sanbing; Cui, Huixian; Wang, Lei; Kang, Lin; Huang, Guannan; Du, Juan; Li, Sha; Tanaka, Hideaki; Su, Yuhong

    2016-07-01

    The appropriate projection of axons within the nervous system is a crucial component of the establishment of neural circuitry. Draxin is a repulsive axon guidance protein. Draxin has important functions in the guidance of three commissures in the central nervous system and in the migration of neural crest cells and dI3 interneurons in the chick spinal cord. Here, we report that the distribution of the draxin protein and the location of 23C10-positive areas have a strong temporal and spatial correlation. The overexpression of draxin, especially transmembrane draxin, caused 23C10-positive axon bundles to misproject in the dorsal hindbrain. In addition, the overexpression of transmembrane draxin caused abnormal formation of the ganglion crest of the IX and X cranial nerves, misprojection of some anti-human natural killer-1 (HNK-1)-stained structures in the dorsal roof of the hindbrain, and a simultaneous reduction in the efferent nerves of some motoneuron axons inside the hindbrain. Our data reveal that draxin might be involved in the fascicular projection of cranial nerves in the hindbrain. PMID:27199282

  13. Axonal synapses utilize multiple synaptic ribbons in the mammalian retina.

    Directory of Open Access Journals (Sweden)

    Hong-Lim Kim

    Full Text Available In the mammalian retina, bipolar cells and ganglion cells which stratify in sublamina a of the inner plexiform layer (IPL show OFF responses to light stimuli while those that stratify in sublamina b show ON responses. This functional relationship between anatomy and physiology is a key principle of retinal organization. However, there are at least three types of retinal neurons, including intrinsically photosensitive retinal ganglion cells (ipRGCs and dopaminergic amacrine cells, which violate this principle. These cell types have light-driven ON responses, but their dendrites mainly stratify in sublamina a of the IPL, the OFF sublayer. Recent anatomical studies suggested that certain ON cone bipolar cells make axonal or ectopic synapses as they descend through sublamina a, thus providing ON input to cells which stratify in the OFF sublayer. Using immunoelectron microscopy with 3-dimensional reconstruction, we have identified axonal synapses of ON cone bipolar cells in the rabbit retina. Ten calbindin ON cone bipolar axons made en passant ribbon synapses onto amacrine or ganglion dendrites in sublamina a of the IPL. Compared to the ribbon synapses made by bipolar terminals, these axonal ribbon synapses were characterized by a broad postsynaptic element that appeared as a monad and by the presence of multiple short synaptic ribbons. These findings confirm that certain ON cone bipolar cells can provide ON input to amacrine and ganglion cells whose dendrites stratify in the OFF sublayer via axonal synapses. The monadic synapse with multiple ribbons may be a diagnostic feature of the ON cone bipolar axonal synapse in sublamina a. The presence of multiple ribbons and a broad postsynaptic density suggest these structures may be very efficient synapses. We also identified axonal inputs to ipRGCs with the architecture described above.

  14. Portable Conduction Velocity Experiments Using Earthworms for the College and High School Neuroscience Teaching Laboratory

    Science.gov (United States)

    Shannon, Kyle M.; Gage, Gregory J.; Jankovic, Aleksandra; Wilson, W. Jeffrey; Marzullo, Timothy C.

    2014-01-01

    The earthworm is ideal for studying action potential conduction velocity in a classroom setting, as its simple linear anatomy allows easy axon length measurements and the worm's sparse coding allows single action potentials to be easily identified. The earthworm has two giant fiber systems (lateral and medial) with different conduction…

  15. Comparison of 1D PDA sampling methods to obtain drop size and velocity distributions inside a spray cone of agricultural nozzles

    NARCIS (Netherlands)

    Holterman, H.J.

    2009-01-01

    In agriculture, spray drift research is carried out in field experiments and by computer simulation. Regarding the latter approach, accurate knowledge of the initial spray is required. Not only is the overall drop size distribution of the spray an important factor in the spraying process, but also i

  16. Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas

    Science.gov (United States)

    Macias, M. Y.; Lehman, C. T.; Sanger, J. R.; Riley, D. A.

    1998-01-01

    Histochemical staining for carbonic anhydrase and cholinesterase (CE) activities was used to analyze sensory and motor axon regeneration, respectively, during neuroma formation in transected and tube-encapsulated peripheral nerves. Median-ulnar and sciatic nerves in the rodent model permitted testing whether a 4 cm greater distance of the motor neuron soma from axotomy site or intrinsic differences between motor and sensory neurons influenced regeneration and neuroma formation 10, 30, and 90 days later. Ventral root radiculotomy confirmed that CE-stained axons were 97% alpha motor axons. Distance significantly delayed axon regeneration. When distance was negligible, sensory axons grew out sooner than motor axons, but motor axons regenerated to a greater quantity. These results indicate regeneration differences between axon subtypes and suggest more extensive branching of motor axons within the neuroma. Thus, both distance from injury site to soma and inherent motor and sensory differences should be considered in peripheral nerve repair strategies.

  17. In vivo imaging of axonal transport using MRI: aging and Alzheimer's disease

    International Nuclear Information System (INIS)

    MRI using manganese as a trans-synaptic axonal tracing agent can unveil dynamics of axonal transport in living subjects. We use this technology to test the hypotheses if impaired axonal transport is a significant pathophysiological process in aging and early Alzheimer's disease (AD) and in part accounting for ''selective vulnerability'' of projection neurons in AD. To allow quantitative assessment of axonal transport in vivo, we developed voxel-based statistical mapping technology as well as a tracer kinetic modeling method based on mass transport for manganese-enhanced MRI to estimate axonal transport rates in aging rats and AD transgenic mice. These techniques demonstrated manganese-enhanced signal changes in axonal projections of the olfactory tract and decreased axonal transport rates in rodent models of aging and AD. Altered axonal transport may be a critical pathophysiological process in aging and AD. Manganese-enhanced MRI provides exciting opportunities for the investigations of altered axonal transport in AD and related disorders. (orig.)

  18. Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Ngang Heok Tang

    2016-04-01

    Full Text Available The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT dynamics have potent effects on axon regeneration. We review recent findings on the regulation of MT dynamics during axon regeneration, focusing on the nematode Caenorhabditis elegans. In C. elegans the dual leucine zipper kinase (DLK promotes axon regeneration, whereas the exchange factor for Arf6 (EFA-6 inhibits axon regeneration. Both DLK and EFA-6 respond to injury and control axon regeneration in part via MT dynamics. How the DLK and EFA-6 pathways are related is a topic of active investigation, as is the mechanism by which EFA-6 responds to axonal injury. We evaluate potential candidates, such as the MT affinity-regulating kinase PAR-1/MARK, in regulation of EFA-6 and axonal MT dynamics in regeneration.

  19. Orientationally invariant indices of axon diameter and density from diffusion MRI

    DEFF Research Database (Denmark)

    Alexander, Daniel C; Hubbard, Penny L; Hall, Matt G;

    2010-01-01

    tensor imaging. Orientational invariance allows for combination with tractography and presents new opportunities for mapping brain connectivity and quantifying disease processes. The technique uses a four-compartment tissue model combined with an optimized multishell high-angular-resolution pulsed......-gradient-spin-echo acquisition. We test the method in simulation, on fixed monkey brains using a preclinical scanner and on live human brains using a clinical 3T scanner. The human data take about one hour to acquire. The simulation experiments show that both monkey and human protocols distinguish distributions of axon...

  20. Seismic velocity structure and spatial distribution of reflection intensity off the Boso Peninsula, Central Japan, revealed by an ocean bottom seismographic experiment

    Science.gov (United States)

    Kono, Akihiro; Sato, Toshinori; Shinohara, Masanao; Mochizuki, Kimihiro; Yamada, Tomoaki; Uehira, Kenji; Shinbo, Takashi; Machida, Yuuya; Hino, Ryota; Azuma, Ryosuke

    2016-04-01

    Off the Boso Peninsula, central Japan, where the Sagami Trough is in the south and the Japan Trench is in the east, there is a triple junction where the Pacific plate (PAC), the Philippine Sea plate (PHS) and the Honshu island arc (HIA) meet each other. In this region, the PAC subducts beneath the PHS and the HIA, and the PHS subducts beneath the HIA. Due to the subduction of 2 oceanic plates, numerous seismic events took place in the past. In order to understand these events, it is important to image structure of these plates. Hence, many researchers attempted to reveal the substructure from natural earthquakes and seismic experiments. Because most of the seismometers are placed inland area and the regular seismicity off Boso is inactive, it is difficult to reveal the precise substructure off Boso area using only natural earthquakes. Although several marine seismic experiments using active sources were conducted, vast area remains unclear off Boso Peninsula. In order to improve the situation, a marine seismic experiment, using airgun as an active source, was conducted from 30th July to 4th of August, 2009. The survey line has 216 km length and 20 Ocean Bottom Seismometers (OBSs) were placed on it. We estimated 2-D P-wave velocity structure from the airgun data using the PMDM (Progressive Model Development Method; Sato and Kenett, 2000) and the FAST (First Arrival Seismic Tomography ; Zelt and Barton, 1998). Furthermore, we identified the probable reflection phases from the data and estimated the location of reflectors using Travel time mapping method (Fujie et al. 2006). We found some reflection phases from the data, and the reflectors are located near the region where P-wave velocity is 5.0 km/s. We interpret that the reflectors indicate the plate boundary between the PHS and the HIA. The variation of the intensity of reflection along the upper surface of PHS seems to be consistent with the result from previous reflection seismic experiment conducted by Kimura et