WorldWideScience

Sample records for axles

  1. Baseline axle load survey in Malawi - 2014

    CSIR Research Space (South Africa)

    Roux, M

    2015-07-01

    Full Text Available As part of the project to update the Malawian Directorate of Road Transport and Safety Services’ (DRTSS) 2005 Axle Load Control Strategy and to provide a five-year implementation plan, a country-wide axle load survey was undertaken to assess...

  2. The Receptor Tyrosine Kinase AXL in Cancer Progression

    Directory of Open Access Journals (Sweden)

    Erinn B. Rankin

    2016-11-01

    Full Text Available The AXL receptor tyrosine kinase (AXL has emerged as a promising therapeutic target for cancer therapy. Recent studies have revealed a central role of AXL signaling in tumor proliferation, survival, stem cell phenotype, metastasis, and resistance to cancer therapy. Moreover, AXL is expressed within cellular components of the tumor microenvironment where AXL signaling contributes to the immunosuppressive and protumorigenic phenotypes. A variety of AXL inhibitors have been developed and are efficacious in preclinical studies. These agents offer new opportunities for therapeutic intervention in the prevention and treatment of advanced disease. Here we review the literature that has illuminated the cellular and molecular mechanisms by which AXL signaling promotes tumor progression and we will discuss the therapeutic potential of AXL inhibition for cancer therapy.

  3. Dynamic analysis of rail vehicle axle

    Indian Academy of Sciences (India)

    In this paper, in order to obtain the dynamic forces on the passenger coach axle, a full rail vehicle model with 19-dof (degrees of freedom) has been considered. For a specific example, the variations of these dynamic forces with velocity of the passenger coach, suspension characteristics and way conditions have been ...

  4. Fatigue lifetime estimation of railway axles

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Pokorný, Pavel; Ševčík, Martin; Fajkoš, R.; Matušek, P.; Hutař, Pavel

    2017-01-01

    Roč. 73, MAR (2017), s. 139-157 ISSN 1350-6307 R&D Projects: GA MŠk LM2015069; GA MŠk(CZ) ED1.1.00/02.0068 Institutional support: RVO:68081723 Keywords : Residual fatigue lifetime * Railway axle * Variable amplitude loading * Fatigue crack propagation * Damage tolerance methodology Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering , reliability analysis Impact factor: 1.676, year: 2016

  5. Single-axle, double-axis solar tracker

    Science.gov (United States)

    Brantley, L. W.; Lawson, B. D.

    1979-01-01

    Solar concentrator tracking mechanism consisting of angular axle and two synchronized drive motors, follows seasonal as well as diurnal changes in earth's orientation with respect to incoming sunlight.

  6. Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism.

    Science.gov (United States)

    Salian-Mehta, S; Xu, M; Knox, A J; Plummer, L; Slavov, D; Taylor, M; Bevers, S; Hodges, R S; Crowley, W F; Wierman, M E

    2014-04-01

    Prior studies showed that Axl /Tyro3 null mice have delayed first estrus and abnormal cyclicity due to developmental defects in GnRH neuron migration and survival. The objective of the study was to test whether the absence of Axl would alter reproductive function in mice and that mutations in AXL are present in patients with Kallmann syndrome (KS) or normosmic idiopathic hypogonadotropic hypogonadism (nIHH). The sexual maturation of Axl null mice was examined. The coding region of AXL was sequenced in 104 unrelated, carefully phenotyped KS or nIHH subjects. Frequency of mutations was compared with other causes of GnRH deficiency. Functional assays were performed on the detected mutations. Axl null mice demonstrated delay in first estrus and the interval between vaginal opening and first estrus. Three missense AXL mutations (p.L50F, p.S202C, and p.Q361P) and one intronic variant 6 bp upstream from the start of exon 5 (c.586-6 C>T) were identified in two KS and 2 two nIHH subjects. Comparison of the frequencies of AXL mutations with other putative causes of idiopathic hypogonadotropic hypogonadism confirmed they are rare variants. Testing of the c.586-6 C>T mutation revealed no abnormal splicing. Surface plasmon resonance analysis of the p.L50F, p.S202C, and p.Q361P mutations showed no altered Gas6 ligand binding. In contrast, GT1-7 GnRH neuronal cells expressing p.S202C or p.Q361P demonstrated defective ligand dependent receptor processing and importantly aberrant neuronal migration. In addition, the p.Q361P showed defective ligand independent chemotaxis. Functional consequences of AXL sequence variants in patients with idiopathic hypogonadotropic hypogonadism support the importance of AXL and the Tyro3, Axl, Mer (TAM) family in reproductive development.

  7. WHEELSET AXLE WITH THE CAVITY OF UNIFORM CROSS SECTION

    Directory of Open Access Journals (Sweden)

    S. R. Kolesnykov

    2014-10-01

    Full Text Available Purpose. Due to operation in complex loading conditions, the rolling stock wheelsets should provide high reliability, since the train traffic safety largely depends on them. Design and technical condition of wheelsets affect the smoothness, intensity of forces generated by the interaction between the car and track, and the motion resistance. Specificity of the axle operation consists in the fact that it undergoes the bending stresses under loading. These stresses are unevenly distributed along the cross-sectional area, reaching the highest values in the outer fibers and the minimal values in the internal ones. This aspect sets the problem of replacement of the uniform cross section with the hollow cross section. The disadvantages of hollow axle design, which are used at the present time, should include a significant manufacturing complexity of the variable section cavity. The purpose is to develop a modernized design of the wheelset axle. Methodology. A construction of the hollow axle having an inner longitudinal cylindrical through hole of the constant diameter throughout its length was proposed. The item is made of steel seamless tube. The inner surface of the tube is treated by mechanical means to remove the voltage concentrations in the internal longitudinal cylindrical through hole, which has a constant diameter along the entire length of the axle. Findings. Application of this design will facilitate manufacturing of the hollow axle and the machining of the inner longitudinal through hole, while retaining all the use advantages of the hollow axle in the rolling stock wheel pairs. Another use advantage of the hollow axle of this design is the absence of partial heterogeneity of the metal, which is inevitably, occurs during the solid axles blanking. Originality. A new design of the wheelset hollow axle of railway rolling stock was proposed. Practical value. Introduction of the new design simplifying the manufacture and mechanical treatment of

  8. Experimental research of the manoeuvrability of a three-tier modular trailer road train in the «car-towing–Dolly-axle truck with fixed axles (dolly–three-axle semi-trailer»

    Directory of Open Access Journals (Sweden)

    Handzyuk D.М.

    2016-12-01

    Full Text Available The paper offers the method of experimental research of movement of the modular three-trailer road train, consisting of three axis of the tractor vehicle, two-axle tow trucks with fixed axles (dolly and three-axle semi-trailer. The results of experimental research are given.

  9. FRONT AXLE OF MERCEDES AMG GT. MODELLING IN AUTODESK INVENTOR

    Directory of Open Access Journals (Sweden)

    COROLENCU Eduard – Narcis

    2017-05-01

    Full Text Available This paper analyzes the front axle of the Mercedes AMG GT model, as so as the graphical representation of the axle and of the subassemblies of suspension system and steering system, using the AutoCAD and Autodesk Inventor software. The paper include the steps for made the 3D model of the front axle in order to highlight the advantages of suspension and steering system, the function of this systems and methods for manufacturing of these. The 3D model presents a suite of complex surfaces. This type of surfaces is often designed with non-analytical means. The main commands and options used in Autodesk Inventor software were presented and explained. All the component parts of the front axle were modelled and assembled according to their functional role. Finally, the models were rendered in order to have a realistic appearance.

  10. Detection of failures of axle-bearings of railway vehicles

    Directory of Open Access Journals (Sweden)

    Bižić Milan B.

    2016-01-01

    Full Text Available The failure of axle-bearing is one of the most common causes of derailments of railway vehicles which are usually accompanied by huge material damage and human casualties. Modern railways are working intensively on the development and implementation of appropriate systems for early detection of axlebearing malfunctions, which are typically manifested by increasing of its temperature. The most common approach is based on the use of wayside systems or checkpoints located in certain places along the track. There is also an innovative approach that involves using the system for continuous measuring and online monitoring of axle-boxes temperature. The main aim is to provide early detection of malfunctions of the axle-bearing and prevention of the potential derailment. This paper analyses the existing solutions for the detection of axle-bearings malfunctions with special emphasis on the working principle and the main advantages and disadvantages. The paper presents the basics of the one newly developed wireless measuring system for on-line monitoring of axle-boxes temperature. The measuring system was tested in real conditions and can be successfully applied to the commercial railway vehicles. The main conclusion is that systems for on-line monitoring of axle-bearings temperatures are far more efficient than wayside systems. Obtained results may be important for those who deal with these and similar problems, problems of development, exploitation and maintenance of railway vehicles, strategies, regulations, etc.

  11. Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling.

    Science.gov (United States)

    Korshunov, Vyacheslav A; Mohan, Amy M; Georger, Mary A; Berk, Bradford C

    2006-06-09

    Intima-media thickening (IMT) in response to hemodynamic stress is a physiological process that requires coordinated signaling among endothelial, inflammatory, and vascular smooth muscle cells (VSMC). Axl, a receptor tyrosine kinase, whose ligand is Gas6, is highly induced in VSMC after carotid injury. Because Axl regulates cell migration, phagocytosis and apoptosis, we hypothesized that Axl would play a role in IMT. Vascular remodeling in mice deficient in Axl (Axl(-/-)) and wild-type littermates (Axl(+/+)) was induced by ligation of the left carotid artery (LCA) branches maintaining flow via the left occipital artery. Both genotypes had similar baseline hemodynamic parameters and carotid artery structure. Partial ligation altered blood flow equally in both genotypes: increased by 60% in the right carotid artery (RCA) and decreased by 80% in the LCA. There were no significant differences in RCA remodeling between genotypes. However, in the LCA Axl(-/-) developed significantly smaller intima+media compared with Axl(+/+) (31+/-4 versus 42+/-6x10(-6) microm3, respectively). Quantitative immunohistochemistry of Axl(-/-) LCA showed increased apoptosis compared with Axl(+/+) (5-fold). As expected, p-Akt was decreased in Axl(-/-), whereas there was no difference in Gas6 expression. Cell composition also changed significantly, with increases in CD45+ cells and decreases in VSMC, macrophages, and neutrophils in Axl(-/-) compared with Axl(+/+). These data demonstrate an important role for Axl in flow-dependent remodeling by regulating vascular apoptosis and vascular inflammation.

  12. A New Approach for Reliability Life Prediction of Rail Vehicle Axle by Considering Vibration Measurement

    Directory of Open Access Journals (Sweden)

    Meral Bayraktar

    2014-01-01

    Full Text Available The effect of vibration on the axle has been considered. Vibration measurements at different speeds have been performed on the axle of a running rail vehicle to figure out displacement, acceleration, time, and frequency response. Based on the experimental works, equivalent stress has been used to find out life of the axles for 90% and 10% reliability. Calculated life values of the rail vehicle axle have been compared with the real life data and it is found that the life of a vehicle axle taking into account the vibration effects is in good agreement with the real life of the axle.

  13. USING COUPLING WEIGHTS AND RATIONAL DISTRIBUTION OF BRAKE FORCES BETWEEN THE AXLES OF WHEELED VEHICLES

    Directory of Open Access Journals (Sweden)

    M. Kholodov

    2011-01-01

    Full Text Available The dependence of the coefficient of coupling weight-axle vehicles under braking and a ra-tional distribution coefficient of braking force to the front axle on the condition of maximum coupling weight.

  14. Effect of Michigan multi-axle trucks on pavement distress and profile: volume 2.

    Science.gov (United States)

    2009-02-01

    With the adoption of the new mechanistic-empirical pavement design method and the employment of axle load spectra, the question of evaluating the pavement damage resulting from different axle and truck configurations has become more relevant. In part...

  15. Effect of Michigan multi-axle trucks on pavement distress and profile: volume 3.

    Science.gov (United States)

    2009-02-01

    With the adoption of the new mechanistic-empirical pavement design method and the employment of axle load : spectra, the question of evaluating the pavement damage resulting from different axle and truck configurations has : become more relevant. In ...

  16. Effect of Michigan multi-axle trucks on pavement distress and profile : volume 1.

    Science.gov (United States)

    2009-02-01

    With the adoption of the new mechanistic-empirical pavement design method and the employment of axle load : spectra, the question of evaluating the pavement damage resulting from different axle and truck configurations has : become more relevant. In ...

  17. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.

    Science.gov (United States)

    Krishnamoorthy, Gnana Prakasam; Guida, Teresa; Alfano, Luigi; Avilla, Elvira; Santoro, Massimo; Carlomagno, Francesca; Melillo, Rosa Marina

    2013-06-14

    The receptor tyrosine kinase AXL is overexpressed in many cancer types including thyroid carcinomas and has well established roles in tumor formation and progression. Proper folding, maturation, and activity of several oncogenic receptor tyrosine kinases require HSP90 chaperoning. HSP90 inhibition by the antibiotic geldanamycin or its derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) causes destabilization of its client proteins. Here we show that AXL is a novel client protein of HSP90. 17-AAG induced a time- and dose-dependent down-regulation of endogenous or ectopically expressed AXL protein, thereby inhibiting AXL-mediated signaling and biological activity. 17-AAG-induced AXL down-regulation specifically affected fully glycosylated mature receptor present on cell membrane. By using biotin and [(35)S]methionine labeling, we showed that 17-AAG caused depletion of membrane-localized AXL by mediating its degradation in the intracellular compartment, thus restricting its exposure on the cell surface. 17-AAG induced AXL polyubiquitination and subsequent proteasomal degradation; under basal conditions, AXL co-immunoprecipitated with HSP90. Upon 17-AAG treatment, AXL associated with the co-chaperone HSP70 and the ubiquitin E3 ligase carboxyl terminus of HSC70-interacting protein (CHIP). Overexpression of CHIP, but not of the inactive mutant CHIP K30A, induced accumulation of AXL polyubiquitinated species upon 17-AAG treatment. The sensitivity of AXL to 17-AAG required its intracellular domain because an AXL intracellular domain-deleted mutant was insensitive to the compound. Active AXL and kinase-dead AXL were similarly sensitive to 17-AAG, implying that 17-AAG sensitivity does not require receptor phosphorylation. Overall our data elucidate the molecular basis of AXL down-regulation by HSP90 inhibitors and suggest that HSP90 inhibition in anticancer therapy can exert its effect through inhibition of multiple kinases including AXL.

  18. Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation*

    Science.gov (United States)

    Krishnamoorthy, Gnana Prakasam; Guida, Teresa; Alfano, Luigi; Avilla, Elvira; Santoro, Massimo; Carlomagno, Francesca; Melillo, Rosa Marina

    2013-01-01

    The receptor tyrosine kinase AXL is overexpressed in many cancer types including thyroid carcinomas and has well established roles in tumor formation and progression. Proper folding, maturation, and activity of several oncogenic receptor tyrosine kinases require HSP90 chaperoning. HSP90 inhibition by the antibiotic geldanamycin or its derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) causes destabilization of its client proteins. Here we show that AXL is a novel client protein of HSP90. 17-AAG induced a time- and dose-dependent down-regulation of endogenous or ectopically expressed AXL protein, thereby inhibiting AXL-mediated signaling and biological activity. 17-AAG-induced AXL down-regulation specifically affected fully glycosylated mature receptor present on cell membrane. By using biotin and [35S]methionine labeling, we showed that 17-AAG caused depletion of membrane-localized AXL by mediating its degradation in the intracellular compartment, thus restricting its exposure on the cell surface. 17-AAG induced AXL polyubiquitination and subsequent proteasomal degradation; under basal conditions, AXL co-immunoprecipitated with HSP90. Upon 17-AAG treatment, AXL associated with the co-chaperone HSP70 and the ubiquitin E3 ligase carboxyl terminus of HSC70-interacting protein (CHIP). Overexpression of CHIP, but not of the inactive mutant CHIP K30A, induced accumulation of AXL polyubiquitinated species upon 17-AAG treatment. The sensitivity of AXL to 17-AAG required its intracellular domain because an AXL intracellular domain-deleted mutant was insensitive to the compound. Active AXL and kinase-dead AXL were similarly sensitive to 17-AAG, implying that 17-AAG sensitivity does not require receptor phosphorylation. Overall our data elucidate the molecular basis of AXL down-regulation by HSP90 inhibitors and suggest that HSP90 inhibition in anticancer therapy can exert its effect through inhibition of multiple kinases including AXL. PMID:23629654

  19. FATIGUE ANALYSIS OF AN AUTOMOBILE REAR AXLE BY USING FINITE ELEMENT METHOD

    Directory of Open Access Journals (Sweden)

    M. İhsan KARAMANGİL

    2007-03-01

    Full Text Available In this study, stress analysis of a native automobile axle exposed to wheel loads is performed and the location of maximum stresses occurring on the axle is determined. Then, it is controlled whether these stresses exceed the limit values or not. In addition, fatigue life of the axle is calculated under selected loads by using finite element method based fatigue analysis. It is shown that the most critical locations on the axle are the regions near to chassis connection points.

  20. Evaluating degradation at railway crossings using axle box acceleration measurements

    NARCIS (Netherlands)

    Wei, Z.; Nunez Vicencio, Alfredo; Li, Z.; Dollevoet, R.P.B.J.

    2017-01-01

    In this paper, we investigate the capability of an axle box acceleration (ABA) system to evaluate the degradation at railway crossings. For this purpose, information from multiple sensors, namely, ABA signals, 3D rail profiles, Global Positioning System (GPS) and tachometer recordings, was

  1. Detection of early squats by axle box acceleration

    NARCIS (Netherlands)

    Molodova, M.

    2013-01-01

    This thesis discusses a new method for detection of short track irregularities, particularly squats, with axle box acceleration (ABA) measurements. A squat is a surface initiated short track defect, associated with high frequency vibrations of the wheel-rail system. High stresses in the contact

  2. Analysis of minimum rail size in heavy axle load environment

    Science.gov (United States)

    2013-04-15

    The effects of increasing axle loads on rail integrity are examined in this paper. In the present context, rail integrity refers to the prevention and control of rail failures. Rail failures usually occur because cracks or defects develop and grow fr...

  3. DACIA LOGAN LIVE AXLE OPTIMISATION USING COMPUTER GRAPHICS

    Directory of Open Access Journals (Sweden)

    KIRALY Andrei

    2017-05-01

    Full Text Available The paper presents some contributions to the calculus and optimisation of a live axle used at Dacia Logan using computer graphics software for creating the model and afterwards using FEA evaluation to determine the effectiveness of the optimisation. Thus using specialized computer software, a simulation is made and the results were compared to the measured real prototype.

  4. LSTM-Based Temperature Prediction for Hot-Axles of Locomotives

    Directory of Open Access Journals (Sweden)

    Luo Can

    2017-01-01

    Full Text Available The reliability of locomotives plays a central role for the smooth operation of railway systems. Hot-axle failures are one of the most commonly found problems leading to locomotive accidents. Since the operating status of the locomotive axle bearings can be distinctly reflected by the axle temperatures, online temperature monitoring has become an essential way to detect hot-axle failures. In this work, we explore the feasibility of predict the hot-axle failures by identifying the temperature from predicted nominal values. We propose a data-driven approach based on the Long Short-Term Memory (LSTM network to predict the sensor temperature for axle bearings. The effectiveness of the prediction model was validated with operation data collected from commercial locomotives. With a prediction accuracy is within a few percent, the proposed techniques can be used as a dynamic reference for hot-axle monitoring.

  5. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Fei [Department of Neurology, Sichuan Medical Science Institute and Sichuan Provincial Hospital, Chengdu 610072 (China); Li, Hongling [Department of Radiotherapy, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 201620 (China); Sun, Yong, E-mail: sunfanqi2010@163.com [Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300 (China)

    2014-11-28

    Highlights: • First reported Axl is co-expressed with ALK in neuroblastoma tissues and cell lines. • Axl activation promotes cell growth and impairs the efficiency of ALK inhibitor. • Further found silence of Axl leads to increased sensitivity to ALK inhibitors. • Axl inhibitor promotes the efficiency of targeted therapy in vitro and in vivo. • Axl activation should be considered in the clinical application of ALK inhibitors. - Abstract: Neuroblastoma (NB) patients harboring mutated ALK can be expected to potentially benefit from targeted therapy based on ALK tyrosine kinase inhibitor (TKI), such as crizotinib and ceritinib. However, the effect of the treatment varies with different individuals, although with the same genic changes. Axl receptor tyrosine kinase is expressed in a variety of human cancers, but little data are reported in NB, particularly in which carrying mutated ALK. In this study, we focus on the roles of Axl in ALK-mutated NB for investigating rational therapeutic strategy. We found that Axl is expressed in ALK-positive NB tissues and cell lines, and could be effectively activated by its ligand GAS6. Ligand-dependent Axl activation obviously rescued crizotinib-mediated suppression of cell proliferation in ALK-mutated NB cells. Genetic inhibition of Axl with specific small interfering RNA markedly increased the sensitivity of cells to ALK-TKIs. Furthermore, a small-molecule inhibitor of Axl significantly enhanced ALK-targeted therapy, as an increased frequency of apoptosis was observed in NB cells co-expressing ALK and Axl. Taken together, our results demonstrated that activation of Axl could lead to insensitivity to ALK inhibitors, and dual inhibition of ALK and Axl might be a potential therapeutic strategy against ALK-mutated NB.

  6. Expression of Axl in Lung Adenocarcinoma and Correlation with Tumor Progression

    Directory of Open Access Journals (Sweden)

    Yi-Shing Shinh

    2005-12-01

    Full Text Available We used the Transwell system to select highly invasive cell lines from minimally invasive parent cells, and we compared gene expression in paired cell lines with high and low invasive potentials. Axl was relatively overexpressed in the highly invasive cell lines when compared with their minimally invasive counterparts. However, there is only limited information about the role of Axl in cancer invasion. The biologic function of Axl in tumor invasion was investigated by overexpression of full-length Axl in minimally invasive cells and by siRNA knockdown of Axl expression in highly invasive cells. Overexpression of Axl in minimally invasive cells increased their invasiveness. siRNA reduced cell invasiveness as Axl was downregulated in highly invasive cells. We further investigated the protein expression of Axl by immunohistochemistry and its correlation with clinicopathologic features. Data from a study of 58 patient specimens showed that Axl immunoreactivity was statistically significant with respect to lymph node status (P < .0001 and the patient's clinical stage (P < .0001. Our results demonstrate that Axl protein kinase seems to play an important role in the invasion and progression of lung cancer.

  7. Optimization of Front Axle Suspension System of Articulated Dump Truck

    DEFF Research Database (Denmark)

    Langer, Thomas Heegaard; Christensen, Brian B.; Mouritsen, Ole Ø.

    2010-01-01

    Manufacturers of construction machinery are challenged to accommodate legal requirements on the vibration exposure associated with their products. For such machines a crucial performance parameter is the whole body vibration level that the operator is subjected to. This paper presents results from...... that has been subjected to comfort improvement is a two axle articulated dump truck. The comfort has been in terms of whole body vibration exposure and the overall improvement has been made possible by adding front axle suspension. However, a hydraulic stabilizing system between the tractor and trailer...... to evaluate the whole body vibrations. By use of a multibody simulation model of the dump truck the whole body vibration exposure has been computed using the predefined work cycle as model input. The design parameters comprise the components of the hydraulic subsystem of the suspension, i.e., the size...

  8. Development of a generalised equivalent estimation approach for multi-axle vehicle handling dynamics

    Science.gov (United States)

    Ding, Jinquan; Guo, Konghui

    2016-01-01

    This paper devotes analytical effort in developing the 2M equivalent approach to analyse both the effect of vehicle body roll and n-axle handling on vehicle dynamics. The 1M equivalent vehicle 2DOF equation including an equivalent roll effect was derived from the conventional two-axle 3DOF vehicle model. And the 1M equivalent dynamics concepts were calculated to evaluate the steady-state steering, frequency characteristics, and root locus of the two-axle vehicle with only the effect of body roll. This 1M equivalent approach is extended to a three-axle 3DOF model to derive similar 1M equivalent mathematical identities including an equivalent roll effect. The 1M equivalent wheelbases and stability factor with the effect of the third axle or body roll, and 2M equivalent wheelbase and stability factor including both the effect of body roll and the third-axle handling were derived to evaluate the steady-state steering, frequency characteristics, and root locus of the three-axle vehicle. By using the recursive method, the generalised 1M equivalent wheelbase and stability factor with the effect of n-axle handling and 2M equivalent generalised wheelbase and stability factor including both the effect of body roll and n-axle handling were derived to evaluate the steady-state steering, frequency characteristics, and root locus of the n-axle vehicle. The 2M equivalent approach and developed generalised mathematical handling concepts were validated to be useful and could serve as an important tool for estimating both the effect of vehicle body roll and n-axle handling on multi-axle vehicle dynamics.

  9. Axl is not an indispensable factor for Zika virus infection in mice.

    Science.gov (United States)

    Wang, Zhao-Yang; Wang, Zai; Zhen, Zi-Da; Feng, Kai-Hao; Guo, Jing; Gao, Na; Fan, Dong-Ying; Han, Dai-Shu; Wang, Pei-Gang; An, Jing

    2017-08-01

    Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain-Barré syndrome and severe fetal abnormalities. However, the mechanism underlying the interaction of ZIKV with host cells is not yet clear. Axl, a receptor tyrosine kinase, is postulated as a receptor for ZIKV entry; however, its in vivo role during ZIKV infection and its impact on the outcome of the disease have not been fully characterized and evaluated. Moreover, there are contradictory results on its involvement in ZIKV infection. Here we utilized Axl-deficient mice (Axl-/-) and their littermates (Axl+/-) to study the in vivo role of Axl in ZIKV infection. Our results showed that both Axl+/- and Axl-/- suckling mice supported the replication of ZIKV and presented clinical manifestations. No significant difference has been found between Axl-deficient mice and their littermates in terms of the survival rate, clinical manifestations, viral load, ZIKV distribution and histopathological changes in major organs. These results therefore indicate that Axl is not an indispensable factor for ZIKV infection in mice.

  10. EVALUATION OF DYNAMIC INDICATORS OF SIX-AXLE LOCOMOTIVE

    Directory of Open Access Journals (Sweden)

    S. V. Myamlin

    2015-04-01

    Full Text Available Purpose. The paper is devoted to dynamic characteristics evaluation of the locomotive with prospective design and determination the feasibility of its use on the Ukrainian railways. Methodology. The methods of mathematical and computer modeling of the dynamics of railway vehicles, as well as methods for the numerical integration of systems of ordinary nonlinear differential equations were used to solve the problem. Findings. The calculated diagram of a locomotive on three-axle bogies was built to solve the problem, and it is a system of rigid bodies connected by various elements of rheology. The mathematical model of the locomotive movement, allowing studying its spatial vibrations at driving on straight and curved sections of the track with random irregularities in plan and profile was developed with use of this calculated diagram. At compiling the mathematical model took into account both geometric (nonlinearity profile of the wheel roll surface and physical nonlinearity of the system (the work forces of dry friction, nonlinearity characteristics of interaction forces between wheels and rails. The multivariate calculations, which allowed assessing the dynamic qualities of the locomotive at its movement along straight and curved sections of the track, were realized with the use of computer modeling. The smoothness movement indicators of the locomotive in horizontal and vertical planes, frame strength, coefficients of vertical dynamics in the first and second stages of the suspension, the load factor of resistance against the derailment of the wheel from the rail were determined at the period of research. In addition, a comparison of the obtained results with similar characteristics is widely used on the Ukrainian railways in six-axle locomotive TE 116. The influence of speed and technical state of the track on the locomotive traffic safety was determined.Originality. A mathematical model of the spatial movement of a six-axle locomotive with

  11. Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses.

    Science.gov (United States)

    Meertens, Laurent; Labeau, Athena; Dejarnac, Ophelie; Cipriani, Sara; Sinigaglia, Laura; Bonnet-Madin, Lucie; Le Charpentier, Tifenn; Hafirassou, Mohamed Lamine; Zamborlini, Alessia; Cao-Lormeau, Van-Mai; Coulpier, Muriel; Missé, Dorothée; Jouvenet, Nolwenn; Tabibiazar, Ray; Gressens, Pierre; Schwartz, Olivier; Amara, Ali

    2017-01-10

    ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains poorly understood. Here, we show that Axl is expressed in human microglia and astrocytes in the developing brain and that it mediates ZIKV infection of glial cells. Axl-mediated ZIKV entry requires the Axl ligand Gas6, which bridges ZIKV particles to glial cells. Following binding, ZIKV is internalized through clathrin-mediated endocytosis and traffics to Rab5+ endosomes to establish productive infection. During entry, the ZIKV/Gas6 complex activates Axl kinase activity, which downmodulates interferon signaling and facilitates infection. ZIKV infection of human glial cells is inhibited by MYD1, an engineered Axl decoy receptor, and by the Axl kinase inhibitor R428. Our results highlight the dual role of Axl during ZIKV infection of glial cells: promoting viral entry and modulating innate immune responses. Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  12. Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

    Directory of Open Access Journals (Sweden)

    Laurent Meertens

    2017-01-01

    Full Text Available ZIKA virus (ZIKV is an emerging pathogen responsible for neurological disorders and congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains poorly understood. Here, we show that Axl is expressed in human microglia and astrocytes in the developing brain and that it mediates ZIKV infection of glial cells. Axl-mediated ZIKV entry requires the Axl ligand Gas6, which bridges ZIKV particles to glial cells. Following binding, ZIKV is internalized through clathrin-mediated endocytosis and traffics to Rab5+ endosomes to establish productive infection. During entry, the ZIKV/Gas6 complex activates Axl kinase activity, which downmodulates interferon signaling and facilitates infection. ZIKV infection of human glial cells is inhibited by MYD1, an engineered Axl decoy receptor, and by the Axl kinase inhibitor R428. Our results highlight the dual role of Axl during ZIKV infection of glial cells: promoting viral entry and modulating innate immune responses. Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies.

  13. Differential expression of Axl in hepatocellular carcinoma and correlation with tumor lymphatic metastasis.

    Science.gov (United States)

    He, Ling; Zhang, Jianing; Jiang, Lili; Jin, Changgong; Zhao, Yongfu; Yang, Guang; Jia, Li

    2010-10-01

    Protein kinases play important roles in tumor development and progression. A variety of members of the signal transduction enzymes serve as targets for therapeutic intervention in cancer. The dysregulation of Axl receptor and its ligand growth arrest-specific 6 (Gas6) is implicated in the pathogenesis of several cancers. In this study, the differential expressions of Axl were investigated in mouse hepatocarcinoma cell lines Hca-F and Hca-P, which have high- and low-metastatic potential to lymph nodes. Experimental inhibition of Axl by siRNA assessed further the metastatic potential of Axl. The results showed that down-regulation of Axl expression attenuated Hca-F cells proliferation, migration, and invasion in vitro, as well as inhibited metastasis to peripheral lymph nodes in vivo. Further analysis demonstrated that the addition of exogenous Gas6 mediated the migration and invasion of Hca-F cells both in vitro and in vivo through Axl. Furthermore, Gas6 stimulation of Axl in Hca-F cells resulted primarily in the down-regulation of Cyr61, a member of the CCN protein family involved in tumor progression. These data suggest that Axl acts as a tumor lymphatic metastasis-associated gene, and may function partly through the regulation of Cyr61. © 2010 Wiley-Liss, Inc.

  14. 49 CFR 230.100 - Defects in tender truck axles and journals.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Defects in tender truck axles and journals. 230... Steam Locomotives and Tenders Running Gear § 230.100 Defects in tender truck axles and journals. (a... wheel seats that is more than 1/8 of an inch in depth. (b) Tender truck journal condemning defects...

  15. Heating Processes Of The Axle-Boxes Of Rolling-Stock On Railway Track Curves

    Directory of Open Access Journals (Sweden)

    Olegas Lunys

    2013-12-01

    Full Text Available The article deals with the heating process of the axle-boxes ofrolling stock when the train is in motion and discusses the forcesacting on the wheel-set when rolling stock moves along the trackcurves. The paper analyses scientific publications relevant tothe forces acting on the wheel-set of rolling stock and focuseson the axle-box heating process. The article also discusses theresults of theoretical studies on wheel-set forces that affect theheat exchange process of axle-boxes for a railway vehicle. Theresearch has determined a change in heating temperatures ofdifferent axle-boxes of rolling stock and reasons for their variationsand tendencies. The paper has estimated an effect of thetrain running along the track curves on the heating intensity ofthe axle-box. Finally, valid conclusions and recommendationshave been provided.

  16. Fatigue life analysis of die forged railway axle manufactured from C30 steel

    Directory of Open Access Journals (Sweden)

    Libor Trško

    2014-06-01

    Full Text Available With respect to the manufacturing process, different parts of one structural component can have different fatigue properties. In this study, the fatigue life of a railway axle manufactured from C30 steel by die forging is evaluated in the part of the axle bolster and axle body. According to the fatigue test results obtained at high frequency tension - compression fatigue tests (f ≈ 20 kHz, R = -1, T = 20 ± 5 °C, due to the higher level of work hardening of the axle bolster, the fatigue strength of material in this part is significantly higher than in the axle body. Different fatigue strength of these parts were observed despite the fact, that results of static tensile tests did not proved any important differences in the ultimate tensile strength, yield point and elongation. 

  17. Analysis of Tendencies Towards Changes in Temperatures of Railway Vehicle Axle Boxes

    Directory of Open Access Journals (Sweden)

    Olegas Lunys

    2012-11-01

    Full Text Available The paper analyzes variations in the temperature of axle-box heating of railroad rolling stock considering two modes of the train - driving and parking position. Additionally, the article describes the influence of the axle load and season on the heat of the axle-box, forecasts intolerable residual resources and explains a possibility of detecting likely breakage at the very beginning of defects. The paper also deals with scientific literature related to axle-box heating and focuses on the conducted practical and theoretical experiments. The carried out research has established the rates of operating heating and critical heating. The application of numerical values for the algorithm of automatic control devices could help with detecting the breakdowns of the axle-box before they reach a critical state and assist in forecasting residual operating resources.

  18. Failure analysis of axle shaft of a fork lift

    Directory of Open Access Journals (Sweden)

    Souvik Das

    2015-04-01

    Full Text Available An axle shaft of fork lift failed at operation within 296 h of service. The shaft transmits torque from discrepancy to wheel through planetary gear arrangement. A section of fractured axle shaft made of induction-hardened steel was analyzed to determine the root cause of the failure. Optical microscopies as well as field emission gun scanning electron microscopy (FEG-SEM along with energy dispersive spectroscopy (EDS were carried out to characterize the microstructure. Hardness profile throughout the cross-section was evaluated by micro-hardness measurements. Chemical analysis indicated that the shaft was made of 42CrMo4 steel grade as per specification. Microstructural analysis and micro-hardness profile revealed that the shaft was improperly heat treated resulting in a brittle case, where crack was found to initiate from the case in a brittle mode in contrast to ductile mode within the core. This behaviour was related to differences in microstructure, which was observed to be martensitic within the case with a micro-hardness equivalent to 735 HV, and a mixture of non-homogeneous structure of pearlite and ferrite within the core with a hardness of 210 HV. The analysis suggests that the fracture initiated from the martensitic case as brittle mode due to improper heat treatment process (high hardness. Moreover the inclusions along the hot working direction i.e. in the longitudinal axis made the component more susceptible to failure.

  19. Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

    Science.gov (United States)

    Vouri, Mikaella; An, Qian; Birt, Matthew; Pilkington, Geoffrey J.; Hafizi, Sassan

    2015-01-01

    Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene overactivation. The Axl receptor tyrosine kinase is found overexpressed in GBM and thought to contribute to invasiveness, chemoresistance and poor survival. Here, we have evaluated the effect of BGB324, a clinical candidate Axl-specific small molecule inhibitor, on the invasive behaviour of human GBM cells in vitro, as an indicator of its potential in GBM therapy and also to elucidate the role of Axl in GBM pathogenesis. Two cultured adult GBM cell lines, SNB-19 and UP007, were treated with Gas6 and/or BGB324, and analysed in assays for survival, 3D colony growth, motility, migration and invasion. Western blot was used to detect protein expression and signal protein phosphorylation. In both cell lines, BGB324 inhibited specifically phosphorylation of Axl as well as Akt kinase further downstream. BGB324 also inhibited survival and proliferation of both cell lines in a concentration-dependent manner, as well as completely suppressing migration and invasion. Furthermore, our results indicate co-operative activation between the Axl and Tyro3 receptors, as well as ligand-independent Axl signalling, to take place in GBM cells. In conclusion, small molecule inhibitor-led targeting of Axl may be a promising therapy for GBM progression. PMID:25980499

  20. Plasma concentrations of sAxl are associated with severe preeclampsia.

    Science.gov (United States)

    Liu, Xijing; Gong, Yunhui; Jia, Jin; Bai, Yi; Gui, Shunping; Wang, Tao; Zhou, Rong

    2014-02-01

    Preeclampsia, a multisystem disorder unique to pregnancy, is a major cause of maternal and perinatal mortality and morbidity. Inadequate trophoblast invasion and vascular dysfunction are believed to be involved in preeclampsia. Axl, which interacts with its ligand Gas6, known to regulate cell migration, adhesion, and vascular angiogenesis or homeostasis and vascular network formation, may be implicated in preeclampsia, as preeclampsia is a specific vascular disease. sAxl, a soluble form of Axl, is bound to Gas6 in plasma, which inhibits the activation of the Axl-Gas6 pathway. The aim of this study was to determine the changes and significance of plasma concentrations of sAxl in severe preeclampsia, as well as its correlation with the clinical parameters of severe preeclampsia. Fifty-eight women with severe preeclampsia and 31 healthy pregnant women were included in the study, from April 2012 to October 2012. Plasma sAxl concentrations were detected with an immunosorbent assay (ELISA) kit. Plasma sAxl concentrations were significantly higher in the preeclampsia group (61.52±17.57ng/mL) than in the normal pregnancy group (45.29±15.44ng/mL) (Ppreeclampsia patients correlated positively with systolic and diastolic blood pressures (r=0.628, Ppreeclampsia patients, and plasma sAxl levels were correlated with the clinical parameters of severe preeclampsia. Furthermore, systolic blood pressure and proteinuria might be influence factors of plasma sAxl level. Copyright © 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  1. Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan.

    Science.gov (United States)

    Fedeli, Chiara; Torriani, Giulia; Galan-Navarro, Clara; Moraz, Marie-Laurence; Moreno, Hector; Gerold, Gisa; Kunz, Stefan

    2018-03-01

    Fatal infection with the highly pathogenic Lassa virus (LASV) is characterized by extensive viral dissemination, indicating broad tissue tropism. The major cellular receptor for LASV is the highly conserved extracellular matrix receptor dystroglycan (DG). Binding of LASV depends on DG's tissue-specific posttranslational modification with the unusual O-linked polysaccharide matriglycan. Interestingly, functional glycosylation of DG does not always correlate with viral tropism observed in vivo The broadly expressed phosphatidylserine (PS) receptors Axl and Tyro3 were recently identified as alternative LASV receptor candidates. However, their role in LASV entry is not entirely understood. Here, we examine LASV receptor candidates in primary human cells and found coexpression of Axl with differentially glycosylated DG. To study LASV receptor use in the context of productive arenavirus infection, we employed recombinant lymphocytic choriomeningitis virus expressing LASV glycoprotein (rLCMV-LASV GP) as a validated biosafety level 2 (BSL2) model. We confirm and extend previous work showing that Axl can contribute to LASV entry in the absence of functional DG using "apoptotic mimicry" in a way similar to that of other enveloped viruses. We further show that Axl-dependent LASV entry requires receptor activation and involves a pathway resembling macropinocytosis. Axl-mediated LASV entry is facilitated by heparan sulfate and critically depends on the late endosomal protein LAMP-1 as an intracellular entry factor. In endothelial cells expressing low levels of functional DG, both receptors are engaged by the virus and can contribute to productive entry. In sum, we characterize the role of Axl in LASV entry and provide a rationale for targeting Axl in antiviral therapy. IMPORTANCE The highly pathogenic arenavirus Lassa virus (LASV) represents a serious public health problem in Africa. Although the principal LASV receptor, dystroglycan (DG), is ubiquitously expressed, virus

  2. Simulation Study on Hot Stamping Forming of the Drive Axle Housing of Heavy Truck

    Science.gov (United States)

    Dai, Yongqian; Ji, Jianyi; Luo, Lingjiang

    2018-01-01

    Aiming at the national energy-saving and emission reduction requirements, lightweight of the heavy truck is imminent. Several parameters related to hot stamping forming process of heavy truck drive axle housing are studied in this paper. The results show that the existing two-step stamping with air cooling molding process, can be improved into one-step hot stamping process. The initial temperature of the blank, stamping speed and other parameters related to the forming process were optimized. The results provides useful reference for improving the existing forming process of the drive axle housing, and it is also helpful for realizing the lightweight design of drive axle housing.

  3. Impact of overweight vehicles (with heavy axle loads) on bridge deck deterioration.

    Science.gov (United States)

    2012-03-01

    Bridge deck slabs develop compressive stresses from global flexural deformation and locally from high-level : wheel loads when it is subjected to overweight trucks. This study quantified the impact of overweight vehicles : with heavy axle loads on br...

  4. Train axle bearing fault detection using a feature selection scheme based multi-scale morphological filter

    Science.gov (United States)

    Li, Yifan; Liang, Xihui; Lin, Jianhui; Chen, Yuejian; Liu, Jianxin

    2018-02-01

    This paper presents a novel signal processing scheme, feature selection based multi-scale morphological filter (MMF), for train axle bearing fault detection. In this scheme, more than 30 feature indicators of vibration signals are calculated for axle bearings with different conditions and the features which can reflect fault characteristics more effectively and representatively are selected using the max-relevance and min-redundancy principle. Then, a filtering scale selection approach for MMF based on feature selection and grey relational analysis is proposed. The feature selection based MMF method is tested on diagnosis of artificially created damages of rolling bearings of railway trains. Experimental results show that the proposed method has a superior performance in extracting fault features of defective train axle bearings. In addition, comparisons are performed with the kurtosis criterion based MMF and the spectral kurtosis criterion based MMF. The proposed feature selection based MMF method outperforms these two methods in detection of train axle bearing faults.

  5. MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Wanqin Wang

    2017-01-01

    Full Text Available AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC. AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT and a potential therapeutic target for TNBC. In this work, we used microPET/CT with 64Cu-labeled anti-human AXL antibody (64Cu-anti-hAXL to noninvasively interrogate the degradation of AXL in vivo in response to 17-allylamino-17-demethoxygeldanamycin (17-AAG, a potent inhibitor of HSP90. 17-AAG treatment caused significant decline in AXL expression in orthotopic TNBC MDA-MB-231 tumors, inhibited EMT, and delayed tumor growth in vivo, resulting in significant reduction in tumor uptake of 64Cu-anti-hAXL as clearly visualized by microPET/CT. Our data indicate that 64Cu-anti-hAXL can be useful for monitoring anti-AXL therapies and for assessing inhibition of HSP90 molecular chaperone using AXL as a molecular surrogate.

  6. DEVELOPMENT OF AN ARMY STATIONARY AXLE TEST STAND FOR LUBRICANT EFFICIENCY EVALUATION-PART II

    Science.gov (United States)

    2017-01-13

    precision when assessing axle gear lubricants to improve ability to discriminate between similarly performing oils • Be modular in design to provide...improve run to run repeatability was the design and implementation of a differential/gear oil temperature control system. Temperature of the differential...Army Tank Automotive Research, Development, and Engineering Center (TARDEC) has initiated the construction and development of a stationary axle

  7. Cyclic Fracture Toughness of Railway Axle and Mechanisms of its Fatigue Fracture

    Directory of Open Access Journals (Sweden)

    Sorochak Andriy

    2015-06-01

    Full Text Available The main regularities in fatigue fracture of the railway axle material - the OSL steel - are found in this paper. Micromechanisms of fatigue crack propagation are described and systematized, and a physical-mechanical interpretation of the relief morphology at different stages of crack propagation is proposed for fatigue cracks in specimens cut out of the surface, internal and central layers of the axle.

  8. Experimental investigation by laser ultrasonics for high speed train axle diagnostics.

    Science.gov (United States)

    Cavuto, A; Martarelli, M; Pandarese, G; Revel, G M; Tomasini, E P

    2015-01-01

    The present paper demonstrates the applicability of a laser-ultrasonic procedure to improve the performances of train axle ultrasonic inspection. The method exploits an air-coupled ultrasonic probe that detects the ultrasonic waves generated by a high-power pulsed laser. As a result, the measurement chain is completely non-contact, from generation to detection, this making it possible to considerably speed up inspection time and make the set-up more flexible. The main advantage of the technique developed is that it works in thermo-elastic regime and it therefore can be considered as a non-destructive method. The laser-ultrasonic procedure investigated has been applied for the inspection of a real high speed train axle provided by the Italian railway company (Trenitalia), on which typical fatigue defects have been expressly created according to standard specifications. A dedicated test bench has been developed so as to rotate the axle with the angle control and to speed up the inspection of the axle surface. The laser-ultrasonic procedure proposed can be automated and is potentially suitable for regular inspection of train axles. The main achievements of the activity described in this paper are: – the study of the effective applicability of laser-ultrasonics for the diagnostic of train hollow axles with variable sections by means of a numerical FE model, – the carrying out of an automated experiment on a real train axle, – the analysis of the sensitivity to experimental parameters, like laser source – receiving probe distance and receiving probe angular position, – the demonstration that the technique is suitable for the detection of surface defects purposely created on the train axle. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Vibroacoustic Modeling and Path Control of Air-Borne Axle Whine Noise

    Directory of Open Access Journals (Sweden)

    Dong Guo

    2014-08-01

    Full Text Available The axle whine noise will eventually affect the vehicle noise performance. In this study, a systematic modeling approach is developed to analyze the axle whine problem by considering the hypoid gear mesh from the tooth contact process as well as the system dynamics effect with gear design parameters and shaft-bearing-housing system taken into account. Moreover, the tuning of the dominant air-borne path is modeled analytically by using the sound transmission loss idea. First, gear tooth load distribution results are obtained in a 3-dimensional loaded tooth contact analysis program. Then mesh parameters are synthesized and applied to a linear multibody gear dynamic model to obtain dynamic mesh and bearing responses. The bearing responses are used as the excitation force to a housing finite element model. Finally, the vibroacoustic analysis of the axle is performed using the boundary element method; sound pressure responses in the axle surface are then simulated. Transmission losses of different panel partitions are included in the final stage to guide the tuning of air-borne paths to reduce the radiated axle whine noise. The proposed approach gives a more in-depth understanding of the axle whine generation and therefore can further facilitate the system design and trouble-shooting.

  10. Influence of polygonal wear of railway wheels on the wheel set axle stress

    Science.gov (United States)

    Wu, Xingwen; Chi, Maoru; Wu, Pingbo

    2015-11-01

    The coupled vehicle/track dynamic model with the flexible wheel set was developed to investigate the effects of polygonal wear on the dynamic stresses of the wheel set axle. In the model, the railway vehicle was modelled by the rigid multibody dynamics. The wheel set was established by the finite element method to analyse the high-frequency oscillation and dynamic stress of wheel set axle induced by the polygonal wear based on the modal stress recovery method. The slab track model was taken into account in which the rail was described by the Timoshenko beam and the three-dimensional solid finite element was employed to establish the concrete slab. Furthermore, the modal superposition method was adopted to calculate the dynamic response of the track. The wheel/rail normal forces and the tangent forces were, respectively, determined by the Hertz nonlinear contact theory and the Shen-Hedrick-Elkins model. Using the coupled vehicle/track dynamic model, the dynamic stresses of wheel set axle with consideration of the ideal polygonal wear and measured polygonal wear were investigated. The results show that the amplitude of wheel/rail normal forces and the dynamic stress of wheel set axle increase as the vehicle speeds rise. Moreover, the impact loads induced by the polygonal wear could excite the resonance of wheel set axle. In the resonance region, the amplitude of the dynamic stress for the wheel set axle would increase considerably comparing with the normal conditions.

  11. Evaluating Degradation at Railway Crossings Using Axle Box Acceleration Measurements

    Directory of Open Access Journals (Sweden)

    Zilong Wei

    2017-09-01

    Full Text Available In this paper, we investigate the capability of an axle box acceleration (ABA system to evaluate the degradation at railway crossings. For this purpose, information from multiple sensors, namely, ABA signals, 3D rail profiles, Global Positioning System (GPS and tachometer recordings, was collected from both nominal and degraded crossings. By proper correlation of the gathered data, an algorithm was proposed to distinguish the characteristic ABA related to the degradation and then to evaluate the health condition of crossings. The algorithm was then demonstrated on a crossing with an unknown degradation status, and its capability was verified via a 3D profile measurement. The results indicate that the ABA system is effective at monitoring two types of degradations. The first type is uneven deformation between the wing rail and crossing nose, corresponding to characteristic ABA frequencies of 230–350 and 460–650 Hz. The second type is local irregularity in the longitudinal slope of the crossing nose, corresponding to characteristic ABA frequencies of 460–650 Hz. The types and severity of the degradation can be evaluated by the spatial distribution and energy concentration of the characteristic frequencies of the ABA signals.

  12. Evaluating Degradation at Railway Crossings Using Axle Box Acceleration Measurements.

    Science.gov (United States)

    Wei, Zilong; Núñez, Alfredo; Li, Zili; Dollevoet, Rolf

    2017-09-29

    In this paper, we investigate the capability of an axle box acceleration (ABA) system to evaluate the degradation at railway crossings. For this purpose, information from multiple sensors, namely, ABA signals, 3D rail profiles, Global Positioning System (GPS) and tachometer recordings, was collected from both nominal and degraded crossings. By proper correlation of the gathered data, an algorithm was proposed to distinguish the characteristic ABA related to the degradation and then to evaluate the health condition of crossings. The algorithm was then demonstrated on a crossing with an unknown degradation status, and its capability was verified via a 3D profile measurement. The results indicate that the ABA system is effective at monitoring two types of degradations. The first type is uneven deformation between the wing rail and crossing nose, corresponding to characteristic ABA frequencies of 230-350 and 460-650 Hz. The second type is local irregularity in the longitudinal slope of the crossing nose, corresponding to characteristic ABA frequencies of 460-650 Hz. The types and severity of the degradation can be evaluated by the spatial distribution and energy concentration of the characteristic frequencies of the ABA signals.

  13. Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells.

    Science.gov (United States)

    Jung, Chi Young; Kim, So-Young; Lee, Chuhee

    2018-01-01

    AXL has been reported to be overexpressed and highly activated in various cancer types. In this study, we demonstrated the effect of carvacrol on cell proliferation and migration in non-small cell lung cancer (NSCLC) cells by impeding the expression and activation of AXL. The levels of AXL protein, mRNA and promoter activity were evaluated by western blot, reverse transcription polymerase chain reaction (RT-PCR) and luciferase assay, respectively. AXL-overexpressing cells were established by ectopic expression of AXL cDNA. Cell viability, clonogenicity, and migration were measured in carvacrol-treated NSCLC cells. Carvacrol treatment of NSCLC cells caused down-regulation of AXL expression at the transcriptional level and also inhibited phosphorylation of AXL upon ligand stimulation. Carvacrol suppressed cell proliferation and migration and its inhibitory effect was attenuated in AXL-overexpressing NSCLC cells. Our data demonstrate that AXL is a crucial therapeutic target of carvacrol-induced inhibition of NSCLC cell proliferation and migration. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  14. Reliability analysis of laser ultrasonics for train axle diagnostics based on model assisted POD curves

    Science.gov (United States)

    Malik, M. S.; Cavuto, A.; Martarelli, M.; Pandarese, G.; Revel, G. M.

    2014-05-01

    High speed train axles are integrated for a lifetime and it is time and resource consuming to conduct in service inspection with high accuracy. Laser ultrasonics is a proposed solution as a subset of non-contact measuring methods effective also for hard to reach areas and even recently proved to be effective using Laser Doppler Vibrometer (LDV) or air-coupled probes in reception. A reliability analysis of laser ultrasonics for this specific application is here performed. The research is mainly based on numerical study of the effect of high energy laser pulses on the surface of a steel axle and of the behavior of the ultrasonic waves in detecting possible defects. Probability of Detection (POD) concept is used as an estimated reliability of the inspection method. In particular Model Assisted Probability of Detection (MAPOD), a modified form of POD where models are used to infer results for making a decisive statistical approach of POD curve, is here adopted. This paper implements this approach by taking the inputs from limited experiments conducted on a high speed train axle using laser ultrasonics (source pulsed Nd:Yag, reception by high-frequency LDV) to calibrate a multiphysics FE model and by using the calibrated model to generate data samples statistically representative of damaged train axles. The simulated flaws are in accordance with the real defects present on the axle. A set of flaws of different depth has been modeled in order to assess the laser ultrasonics POD for this specific application.

  15. Fault Diagnosis of Train Axle Box Bearing Based on Multifeature Parameters

    Directory of Open Access Journals (Sweden)

    Xiaofeng Li

    2015-01-01

    Full Text Available Failure of the train axle box bearing will cause great loss. Now, condition-based maintenance of train axle box bearing has been a research hotspot around the world. Vibration signals generated by train axle box bearing have nonlinear and nonstationary characteristics. The methods used in traditional bearing fault diagnosis do not work well with the train axle box. To solve this problem, an effective method of axle box bearing fault diagnosis based on multifeature parameters is presented in this paper. This method can be divided into three parts, namely, weak fault signal extraction, feature extraction, and fault recognition. In the first part, a db4 wavelet is employed for denoising the original signals from the vibration sensors. In the second part, five time-domain parameters, five IMF energy-torque features, and two amplitude-ratio features are extracted. The latter seven frequency domain features are calculated based on the empirical mode decomposition and envelope spectrum analysis. In the third part, a fault classifier based on BP neural network is designed for automatic fault pattern recognition. A series of tests are carried out to verify the proposed method, which show that the accuracy is above 90%.

  16. Dynamic Characteristics of a New Machine for Fatigue Testing of Railway Axles – Part 2

    Directory of Open Access Journals (Sweden)

    Karel FRYDRÝŠEK

    2012-06-01

    Full Text Available There were done some proposal calculations for a new testing machine. This new testing machine is determined for a dynamic fatigue testing of railway axles. The railway axles are subjected to bending and rotation (centrifugal effects. For the right proposition of a new machine is very important to know the basic dynamic characteristics of whole system. These dynamic characteristics are solved via FEM (MSC.Marc/Mentat software in combination with SBRA (Simulation-Based Reliability Assessment Method (probabilistic Monte Carlo approach, Anthill and Python software. The proposed dimensions and springs of a new machine for fatigue testing of railway axles were used for manufacturing. Application of the SBRA method connected with FEM in these areas is a new and innovative trend in mechanics. This paper is continuation of former work (i.e. easier deterministic approach already presented in this journal in 2007.

  17. Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response.

    Directory of Open Access Journals (Sweden)

    Scott A Read

    Full Text Available Treatment of chronic hepatitis C virus (HCV infection is evolving rapidly with the development of novel direct acting antivirals (DAAs, however viral clearance remains intimately linked to the hepatic innate immune system. Patients demonstrating a high baseline activation of interferon stimulated genes (ISGs, termed interferon refractoriness, are less likely to mount a strong antiviral response and achieve viral clearance when placed on treatment. As a result, suppressor of cytokine signalling (SOCS 3 and other regulators of the IFN response have been identified as key candidates for the IFN refractory phenotype due to their regulatory role on the IFN response. AXL is a receptor tyrosine kinase that has been identified as a key regulator of interferon (IFN signalling in myeloid cells of the immune system, but has not been examined in the context of chronic HCV infection. Here, we show that AXL is up-regulated following HCV infection, both in vitro and in vivo and is likely induced by type I/III IFNs and inflammatory signalling pathways. AXL inhibited type IFNα mediated ISG expression resulting in a decrease in its antiviral efficacy against HCV in vitro. Furthermore, patients possessing the favourable IFNL3 rs12979860 genotype associated with treatment response, showed lower AXL expression in the liver and a stronger induction of AXL in the blood, following their first dose of IFN. Together, these data suggest that elevated AXL expression in the liver may mediate an IFN-refractory phenotype characteristic of patients possessing the unfavourable rs12979860 genotype, which is associated with lower rates of viral clearance.

  18. Crack closure in near-threshold fatigue crack propagation in railway axle steel EA4T

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Pavel; Vojtek, Tomáš; Náhlík, Luboš; Hutař, Pavel

    2017-01-01

    Roč. 185, NOV (2017), s. 2-19 ISSN 0013-7944 R&D Projects: GA MŠk(CZ) LQ1601 Institutional support: RVO:68081723 Keywords : Fatigue crack propagation * crack closure * EA4T * Railway axle Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering, reliability analysis Impact factor: 2.151, year: 2016

  19. On Optimizing Steering Performance of Multi-axle Vehicle Based on Driving Force Control

    Directory of Open Access Journals (Sweden)

    Wu Zhicheng

    2017-01-01

    Full Text Available The steering performance of multi-axle vehicle with independent driving system is affected by the distribution of the wheel driving force. A nonlinear vehicle dynamics model including magic formula tire model for describing 11 DoF four-axle vehicle with dual-front-axle-steering (DFAS system was presented. The influence of different driving force distribution scheme on the steering performance of the vehicle was analyzed. A control strategy for improving the steady response and transient response of the vehicle steering is proposed. The results show: For the steady response, setting different drive force for internal and external wheels according to the actual steering characteristics of the vehicle can effectively improve its steering characteristics; For the transient response, adopting the zero sideslip angle control strategy and using the PID control algorithm to control the driving force of the outside wheel of tear-two-axle, under angle step input, the vehicle sideslip angle can quickly stabilize to 0 and yaw rate also significantly decreases.

  20. Dynamics of two-axle railway freight wagons with UIC standard suspension

    DEFF Research Database (Denmark)

    Hoffmann, Mark; True, Hans

    2006-01-01

    The dynamics of two different two-axle railway freight wagons is investigated theoretically and compared. Fully nonlinear models are considered. The hysteresis from dry friction and the effect of impacts between elements of the suspension are included. Bifurcation diagrams are shown in order...

  1. Wheeled Vehicle Drive Lines, Axles, and Suspension Systems. Military Curriculum Materials for Vocational and Technical Education.

    Science.gov (United States)

    Army Ordnance Center and School, Aberdeen Proving Ground, MD.

    This course is one of several subcourses that make up the entire Army correspondence course on wheeled vehicle maintenance. The subcourse is designed to provide the student with information about the operation, malfunction diagnosis, maintenance, and repair of wheeled vehicle drive lines, axles, and suspension systems. It provides the basic…

  2. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

    Directory of Open Access Journals (Sweden)

    Prieto Anne L

    2011-05-01

    Full Text Available Abstract Background Axl, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6 are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS lesions, suggesting that it plays a role in disease pathogenesis. To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis. Methods WT and Axl-/- mice were immunized with myelin oligodendrocyte glycoprotein (MOG35-55 peptide emulsified in complete Freund's adjuvant and injected with pertussis toxin on day 0 and day 2. Mice were monitored daily for clinical signs of disease and analyzed for pathology during the acute phase of disease. Immunological responses were monitored by flow cytometry, cytokine analysis and proliferation assays. Results Axl-/- mice had a significantly more severe acute phase of EAE than WT mice. Axl-/- mice had more spinal cord lesions with larger inflammatory cuffs, more demyelination, and more axonal damage than WT mice during EAE. Strikingly, lesions in Axl-/- mice had more intense Oil-Red-O staining indicative of inefficient clearance of myelin debris. Fewer activated microglia/macrophages (Iba1+ were found in and/or surrounding lesions in Axl-/- mice relative to WT mice. In contrast, no significant differences were noted in immune cell responses between naïve and sensitized animals. Conclusions These data show that Axl alleviates EAE disease progression and suggests that in EAE Axl functions in the recruitment of microglia/macrophages and in the clearance of debris following demyelination. In addition, these data

  3. Observation and Simulation of Axle Box Acceleration in the Presence of Rail Weld in High-Speed Railway

    Directory of Open Access Journals (Sweden)

    Boyang An

    2017-12-01

    Full Text Available Rail welds are widely used in high-speed railways and short-wave irregularities usually appear due to limitations in welding technology. These irregularities can excite a high wheel/rail force and are regarded as the main cause of deterioration in track structures. To measure this fierce force (or deterioration of the rail weld, axle box acceleration is treated as an effective and economic measure, though an exact quantitative relation between these two quantities remains elusive. This paper aims to develop such a relation in order to provide a new theoretical basis and an analysis method for monitoring and controlling weld geometry irregularity. To better understand the characteristics of axle box acceleration, the paper consists of two parts: an observation and a numerical simulation of axle box acceleration by rail welds. Based on measured data from field tests, axle box acceleration at rail welds was found to have high-frequency vibrations in two frequency bands (i.e., 350–500 Hz and 1000–1200 Hz. Upon analyzing the vibration characteristics in time–frequency domains, the exact location of the rail weld irregularity could be identified. Subsequently, a 3D high-speed wheel/rail rolling contact finite element model was employed to investigate the effect of rail weld geometry on axle box acceleration, and led to the discovery that the weld length and depth determine the vibration frequency and amplitude of the axle box acceleration, respectively. A quantitative relation between axle box acceleration and wheel/rail force has also been determined. Finally, we propose an approach for real-time health detection of rail welds and discuss the influence of other defects and rail welds on the acceleration signal of the axle box.

  4. GEOMETRIC ANALYSIS OF MANEUVERABILITY PERFORMANCE FOR VEHICLES WITH TWO STEERING AXLES

    Directory of Open Access Journals (Sweden)

    Jędrzej PILISIEWICZ

    2017-06-01

    Full Text Available One of the most important features of motor vehicles is their steering maneuverability. Ways of determining single axle steering are well known. This paper presents an idea of how to determine maneuverability of motor vehicles with two steering axles. The concept makes use of elements of kinematic analysis as well as of a 3D model of the steering system. It is based on the theoretical analysis of the most unfavorable situations, such as parallel and perpendicular parking techniques, on the basis of which wheel-steering angles are specified. As a result, it was possible to create a 3D model to simulate the actual operation of the steering system. This made it possible to compare the theoretical approach with the actual system design.

  5. On the vertical interaction between a three-axle bogie and track

    Directory of Open Access Journals (Sweden)

    Mazilu Traian

    2017-01-01

    Full Text Available In this paper, the ‘moving wheel’ model is used aiming to analysis new aspects of the interaction between three-axle bogie and track due to the harmonic roughness of the rail. The three-axle bogie of a locomotive is considered and its model is reduced to three loaded wheels running along a rail supported on a continuous elastic foundation. The track model consists of a Euler-Bernoulli beam resting on elastic foundation including two elastic layers (Winkler model representing the rail pad and ballast and one inertial layer for sleepers. The rail deflection due to the moving dead loads of the wheels is calculated and the frequency response functions of the wheels, rail in the contact points and contact forces are analysed, including the three resonance frequencies.

  6. Influence of Initial Inclined Surface Crack on Estimated Residual Fatigue Lifetime of Railway Axle

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Pokorný, Pavel; Ševčík, Martin; Hutař, Pavel

    2016-01-01

    Roč. 7, č. 4 (2016), č. článku 1640007. ISSN 1756-9737. [FDM 2016 - International Conference on Fracture and Damage Mechanics /15./. Alicante, 14.09.2016-16.09.2016] R&D Projects: GA MŠk LM2015069; GA MŠk(CZ) ED1.1.00/02.0068 Institutional support: RVO:68081723 Keywords : inclined crack * railway axle * residual fatigue lifetime * fatigue crack propagation Subject RIV: JL - Materials Fatigue, Friction Mechanics

  7. Residual fatigue lifetime estimation of railway axles for various loading spectra

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Pavel; Hutař, Pavel; Náhlík, Luboš

    2016-01-01

    Roč. 82, APR (2016), s. 25-32 ISSN 0167-8442 R&D Projects: GA MŠk(CZ) EE2.3.20.0214; GA MŠk(CZ) ED1.1.00/02.0068 Institutional support: RVO:68081723 Keywords : Fatigue failure * Residual fatigue lifetime * Crack propagation * Railway axle * Load spectrum Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 2.659, year: 2016

  8. Molecular analysis of alternative transcripts of equine AXL receptor tyrosine kinase gene

    Directory of Open Access Journals (Sweden)

    Jeong-Woong Park

    2017-10-01

    Full Text Available Objective Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form in equine skeletal muscle to gain insight(s into the role of each alternative transcript during exercise. Methods We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR, and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR. Results Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3 and immunoglobin (Ig domain was different between two alternative isoforms. Conclusion It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an NF-κB signaling pathway. Further study is necessary to uncover biological function(s and significance of the alternative splicing isoforms in race horse skeletal muscle.

  9. A Flexible Arrayed Eddy Current Sensor for Inspection of Hollow Axle Inner Surfaces

    Directory of Open Access Journals (Sweden)

    Zhenguo Sun

    2016-06-01

    Full Text Available A reliable and accurate inspection of the hollow axle inner surface is important for the safe operation of high-speed trains. In order to improve the reliability of the inspection, a flexible arrayed eddy current sensor for non-destructive testing of the hollow axle inner surface was designed, fabricated and characterized. The sensor, consisting of two excitation traces and 28 sensing traces, was developed by using the flexible printed circuit board (FPCB technique to conform the geometric features of the inner surfaces of the hollow axles. The main innovative aspect of the sensor was the new arrangement of excitation/sensing traces to achieve a differential configuration. Finite element model was established to analyze sensor responses and to determine the optimal excitation frequency. Experimental validations were conducted on a specimen with several artificial defects. Results from experiments and simulations were consistent with each other, with the maximum relative error less than 4%. Both results proved that the sensor was capable of detecting longitudinal and transverse defects with the depth of 0.5 mm under the optimal excitation frequency of 0.9 MHz.

  10. A Study on Lean Manufacturing Practice Carried Out for Axle Housing Plant

    Directory of Open Access Journals (Sweden)

    Rishi J. P.

    2018-01-01

    Full Text Available Lean Manufacturing is a way to deal with the elimination of waste through persistent change within the system. The assembling units in India should likewise hope to take its preferences. The Industries are energetically following the Lean assembling strategies to reduce waste and cost. The present work is the study of a manufacturing process for axle housing and to decide how Lean manufacturing process carried out for axle housing plant to improve productivity. The new shot peening machine was installed in a heat treatment plant of a housing line in an automobile rear axle assembly plant and material handling time from storage to this new machine was more and this increased lead time subsequently. To reduce this Kaizens technique was employed and a direct gravity conveyor was chosen and installed between two work stations and the part was directly fed to the new machine installed and this reduces the material handling time considerably. A cost analysis was done to realize the benefits of implementing this lean technique. Therefore reducing lead time and increasing productivity is the Prime benefits of lean manufacturing practices like lean assembly.

  11. Heavy and Overweight Vehicle Brake Testing: Five-Axle Combination Tractor-Flatbed Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lascurain, Mary Beth [ORNL; Capps, Gary J [ORNL; Franzese, Oscar [ORNL

    2013-10-01

    The Federal Motor Carrier Safety Administration, in coordination with the Federal Highway Administration, sponsored the Heavy and Overweight Vehicle Brake Testing (HOVBT) program in order to provide information about the effect of gross vehicle weight (GVW) on braking performance. Because the Federal Motor Carrier Safety Regulations limit the number of braking system defects that may exist for a vehicle to be allowed to operate on the roadways, the examination of the effect of brake defects on brake performance for increased loads is also relevant. The HOVBT program seeks to provide relevant information to policy makers responsible for establishing load limits, beginning with providing test data for a combination tractor/trailer. This testing was conducted on a five-axle combination vehicle with tractor brakes meeting the Reduced Stopping Distance requirement rulemaking. This report provides a summary of the testing activities, the results of various analyses of the data, and recommendations for future research. Following a complete brake rebuild, instrumentation, and brake burnish, stopping tests were performed from 20 and 40 mph with various brake application pressures (15 psi, 25 psi, 35 psi, 45 psi, 55 psi, and full system pressure). These tests were conducted for various brake conditions at the following GVWs: 60,000, 80,000, 91,000, 97,000, 106,000, and 116,000 lb. The 80,000-lb GVWs included both balanced and unbalanced loads. The condition of the braking system was also varied. To introduce these defects, brakes (none, forward drive axle, or rear trailer axle) were made inoperative. In addition to the stopping tests, performance-based brake tests were conducted for the various loading and brake conditions. Analysis of the stopping test data showed the stopping distance to increase with load (as expected) and also showed that more braking force was generated by the drive axle brakes than the trailer axle brakes. The constant-pressure stopping test data

  12. Synthesis of the adaptive continuous system for the multi-axle wheeled vehicle body oscillation damping

    Science.gov (United States)

    Zhileykin, M. M.; Kotiev, G. O.; Nagatsev, M. V.

    2018-02-01

    In order to meet the growing mobility requirements for the wheeled vehicles on all types of terrain the engineers have to develop a large number of specialized control algorithms for the multi-axle wheeled vehicle (MWV) suspension improving such qualities as ride comfort, handling and stability. The authors have developed an adaptive algorithm of the dynamic damping of the MVW body oscillations. The algorithm provides high ride comfort and high mobility of the vehicle. The article discloses a method for synthesis of an adaptive dynamic continuous algorithm of the MVW body oscillation damping and provides simulation results proving high efficiency of the developed control algorithm.

  13. Recommendations regarding higher axlemass limits for axles fitted with wide base tyres

    CSIR Research Space (South Africa)

    Roux, MP

    2011-01-01

    Full Text Available current legal limits on axles fitted with single tyres. Due to the wider base (tread width) of these tyres, the premise is that the contact area between wide base tyres and the road surface should be relatively larger and the tyre contact stress... contact stress and the second assumption is that the maximum diameter of the contact area equals the nominal section width of the tyre. For both assumptions the contact area is considered to be of the traditional circular shape for the M-E analyses...

  14. Product Design and Production Practice of 700MPa High Strength Hot Rolled Strip for Auto Axle Tube

    Science.gov (United States)

    Hui, Pan; Zhao-dong, Wang; Ya-jun, Hui; Yang, Cui; Xiang-tao, Deng; Chun-lin, Bao

    According to the technical specifications of 700MPa high strength automotive axle tube steel, a low cost of 0.07%C+1.5%Mn+0.05%Nb+0.10%Ti was designed. The high strength mainly relies on grain refinement strengthening and precipitation strengthening. The recrystallization, precipitation, and CCT curves of the 700MPa grade axle tube steel were studied in order to determine a reasonable TMCP process. By controlling the low level segregation band, low level of C and N content, 700MPa grade high strength automotive axle tube steel is successfully developed with excellent mechanical property, welding property, flattening and flaring property, torsion fatigue property, static torsional property and surface quality.

  15. Stiffness determination of the controlled wheel module of a two-axle vehicle

    Directory of Open Access Journals (Sweden)

    Belevtseva N.V.

    2016-08-01

    Full Text Available The conditions of a secure loss of stability of a two-axle wheel vehicle with absolutely hard steering have been found before. The analytically derived conditions of a secure stability loss in case of torsional stiffness are dependent on the relationship between the slipping resistance coefficients, the transverse clutch coefficients on the axes, and the torsional stiffness of the controlled wheel module. In this case, the trail distance is taken into account in the wheel module control system, the mass of the module being neglected. The approach suggested in the paper does take into account the mass of the controlled wheel module. The slipping forces are presented accurate to a cubic term of expansion in slipping angles. The torsional stiffness intervals have been found that provide a secure loss of stability of a two-axle wheel vehicle model. The intervals have been obtained on the basis of a bifurcation analysis of actual bifurcations of the stationary states in the vicinity of the rectilinear motion of the model. Diagrams that illustrate the fulfillment of secure stability loss conditions and allow using the results obtained in designing a wheel module are presented in the paper. The technique used is alternative to the well-known M. Bautin’s approach to determination of secure-insecure conditions in case of a divergent loss of stability.

  16. NEW APPROACH FOR TECHNOLOGY OF VOLUMETRIC – SUPERFICIAL HARDENING OF GEAR DETAILS OF THE BACK AXLE OF MOBILE MACHINES

    Directory of Open Access Journals (Sweden)

    A. I. Mihluk

    2010-01-01

    Full Text Available The new approach for technology of volumetric – superficial hardening of gear details of the back axle made of steel lowered harden ability is offered. This approach consisting in formation of intense – hardened condition on all surface of a detail.

  17. 75 FR 52981 - Chrysler, LLC, Detroit Axle Plant, Including On-Site Leased Workers from Caravan Knight...

    Science.gov (United States)

    2010-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Chrysler, LLC, Detroit Axle Plant, Including On-Site Leased Workers from Caravan Knight Facilities Management LLC, and Syncreon, Detroit, MI; Amended Certification Regarding Eligibility To Apply for Worker Adjustment...

  18. 75 FR 11914 - Chrysler, LLC, Detroit Axle Plant, Including On-Site Leased Workers From Caravan Knight...

    Science.gov (United States)

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Chrysler, LLC, Detroit Axle Plant, Including On-Site Leased Workers From Caravan Knight Facilities Management LLC; Detroit, MI; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance and...

  19. Analysis of axle and vehicle load properties through Bayesian networks based on weigh-in-motion data

    NARCIS (Netherlands)

    Morales Napoles, O.; Steenbergen, R.D.J.M.

    2014-01-01

    Weigh-in-Motion (WIM) systems are used, among other applications, in pavement and bridge reliability. The system measures quantities such as individual axle load, vehicular loads, vehicle speed, vehicle length and number ofaxles. Because ofthe nature ofúamc configuration, the quantities measured are

  20. Study on control schemes of flexible steering system of a multi-axle all-wheel-steering robot

    Directory of Open Access Journals (Sweden)

    Pingxia Zhang

    2016-05-01

    Full Text Available It is well known that a multi-axle wheeled robot possesses larger load capability and also higher drive performance. However, its steering flexibility is degraded due to the large number of wheels. In order to solve this problem, in this article, we proposed three control schemes based on the center of rotation or the steering angles of both the first- and last-axle wheels. To release these control schemes, steering mode selection and also the left wheel’s steering angle in a specific axle are added approaching a practical application. Thereafter, the remaining wheels’ steering angles can be calculated with the Ackerman steering theorem. In order to verify the control effects, a five-axle all-wheel-steering wheeled robot has been developed with the Bluetooth wireless monitor system. Based on the newly designed robot, validation experiments are carried out, such as lateral movement, situ rotation, and multi-mode steering within a narrow space. The results indicate that the proposed design in this article can ensure a more flexible and faster movement within a narrow space. It shows large potential in obstacle avoidance compared with the conventional partial-wheel steering mode.

  1. Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling.

    Science.gov (United States)

    Wang, Cun; Jin, Haojie; Wang, Ning; Fan, Shaohua; Wang, Yanyan; Zhang, Yurong; Wei, Lin; Tao, Xuemei; Gu, Dishui; Zhao, Fangyu; Fang, Jingyuan; Yao, Ming; Qin, Wenxin

    2016-01-01

    Chemoresistance in breast cancer has been of great interest in past studies. However, the development of rational therapeutic strategies targeting chemoresistant cells is still a challenge in clinical oncology. By integrating data from global differences of gene expression and phospho-receptor tyrosine kinases between sensitive parental cells (MCF-7) and doxorubicin-resistant cells (MCF-7/ADR), we identified Axl as a potential target for chemoresistance and metastasis in multidrug resistant breast cancer cells. We analyzed Axl expression in 57 breast cancer cell lines and detected a dramatic increase in its expression level in mesenchymal breast cancer cell lines. Axl silencing suppressed invasive and metastatic potentials of chemoresistant breast cancer cells as well as increased elimination of cancer cells when combined with doxorubicin. Furthermore, in preclinical assays, an Axl inhibitor R428 showed increased cell death upon doxorubicin treatment. Additionally, using phospho-kinase array based proteomic analysis, we identified that Akt/GSK-3β/β-catenin cascade was responsible for Axl-induced cell invasion. Nuclear translocation of β-catenin then induced transcriptional upregulation of ZEB1, which in turn regulated DNA damage repair and doxorubicin-resistance in breast cancer cells. Most importantly, Axl was correlated with its downstream targets in tumor samples and was associated with poor prognosis in breast cancer patients. These results demonstrate that Gas6/Axl axis confers aggressiveness in breast cancer and may represent a therapeutic target for chemoresistance and metastasis.

  2. Levels of vibration transmitted to the operator of the tractor equipped with front axle suspension

    Directory of Open Access Journals (Sweden)

    Daniele Pochi

    2013-09-01

    Full Text Available In recent years the comfort and the preservation of the health of the operators became central issues in the evolution of agricultural machinery and led to the introduction of devices aimed at improving working conditions. Thereby, for instance, the presence of air conditioner, soundproof cab and driver seat suspension became normal on agricultural tractors. The vibrations are one of the most complex issues to deal with, being determined by the characteristics and interaction of elements such as tyres, axles, mainframe, cab and seat suspension. In this respect, manufacturers are trying to improve their products, even integrating these elements with new devices such as the suspension on the front axle of the tractor, aimed at reducing the level of vibrations during the transfers at high speed. One of these underwent tests at CRA-ING. Since its purpose is to reduce the level of vibration transmitted to the driver, their measurements in different points of the tractor and in different operating conditions, were compared in order to evaluate the effectiveness of the device, expressed as time of exposure. The suspension system of the front axle is designed to absorb the oscillations (especially pitching determined by irregularities in the road surface, allowing an increased control of the vehicle at high speed, as demonstrated by the test results and confirmed by the driving impressions outlined by the operator. The action of the device under these conditions results in an increase of the exposure time, important fact because of the relevance of the road transfer operations of tractors with mounted implements or trailers to tow and of the tendency to increase the speed limit for the road tractors (in Germany were brought to 50 km h–1 for several years. The action just described is less evident with increasing irregularity of the road surface and with the decrease of the travel speed. Nevertheless, in such conditions, the device appears to

  3. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy.

    Science.gov (United States)

    Kanzaki, Ryu; Naito, Hisamichi; Kise, Kazuyoshi; Takara, Kazuhiro; Eino, Daisuke; Minami, Masato; Shintani, Yasushi; Funaki, Soichiro; Kawamura, Tomohiro; Kimura, Toru; Okumura, Meinoshin; Takakura, Nobuyuki

    2017-09-06

    Alterations to the tumor stromal microenvironment induced by chemotherapy could influence the behavior of cancer cells. In the tumor stromal microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because the receptor tyrosine kinase Axl and its ligand Gas6 could be involved in promoting non-small cell lung cancer (NSCLC), we investigated the role of Gas6 secreted by CAFs during chemotherapy in NSCLC. In a murine model, we found that Gas6 expression by CAFs was upregulated following cisplatin treatment. Gas6 expression might be influenced by intratumoral hypoperfusion during chemotherapy, and it increased after serum starvation in a human lung CAF line, LCAF hTERT . Gas6 is associated with LCAF hTERT cell growth. Recombinant Gas6 promoted H1299 migration, and conditioned medium (CM) from LCAF hTERT cells activated Axl in H1299 cells and promoted migration. Silencing Gas6 in LCAF hTERT reduced the Axl activation and H1299 cell migration induced by CM from LCAF hTERT . In clinical samples, stromal Gas6 expression increased after chemotherapy. Five-year disease-free survival rates for patients with tumor Axl- and stromal Gas6-positive tumors (n = 37) was significantly worse than for the double negative group (n = 12) (21.9% vs 51.3%, p = 0.04). Based on these findings, it is presumed that Gas6 derived from CAFs promotes migration of Axl-expressing lung cancer cells during chemotherapy and is involved in poor clinical outcome.

  4. Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers.

    Science.gov (United States)

    Grabiec, Aleksander M; Goenka, Anu; Fife, Mark E; Fujimori, Toshifumi; Hussell, Tracy

    2018-02-05

    The requirement to remove apoptotic cells is equally important in homeostasis and inflammatory disease. In particular, during viral infections large quantities of infected cells undergo apoptosis and need to be efficiently cleared by phagocytes to prevent secondary necrosis. Although specific roles of several apoptotic cell sensors, such as the TAM (Tyro3, Axl, MerTK) receptor family, have been characterized in mouse models, little is known about their regulation and involvement in apoptotic cell uptake (efferocytosis) by human macrophages under inflammatory conditions. We show that whereas pro-inflammatory stimuli consistently downregulated MerTK expression in human monocyte-derived macrophages (MDMs), stimuli indicative of a viral infection, interferon-α (IFN-α) and the TLR3 ligand poly(I:C), specifically induced Axl expression and promoted binding of the bridging molecule Gas6. Axl induction by IFN-α and poly(I:C) was associated with higher MDM efferocytic capacity compared to cells treated with other pro-inflammatory stimuli, such as LPS and IFN-γ. While MerTK blocking antibody uniformly suppressed apoptotic cell uptake by MDMs, Axl blocking antibody significantly reduced efferocytosis by poly(I:C)-stimulated MDMs, but not by resting MDMs. Our observations demonstrate that Axl induction during viral infections contributes to maintaining macrophage capacity to engulf apoptotic cells, which may have important consequences for resolution of anti-viral immune responses. © 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors.

    Science.gov (United States)

    Ren, Dongliang; Li, Yanyan; Gong, Yanxin; Xu, Jingchao; Miao, Xiaolong; Li, Xiangnan; Liu, Chen; Jia, Li; Zhao, Yongfu

    2014-10-01

    Phyllodes tumor exhibits an aggressive growth. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The purpose of this study was to evaluate the implications of Axl and ST6GalNAcII in phyllodes tumors. Real-time PCR, Western blot, and immunohistochemical were used to analyze differential expression of ST6GalNAcII and Axl in phyllodes tumor (PT) cell lines and tissue specimens. RNAi assay, ECM invasion assay, and tumorigenicity assay were used to analyze the altered expression of ST6GalNAcII gene effects on the expression of Axl and invasive ability of phyllodes tumor cells in vitro and in vivo. Compared to benign tumors, borderline and malignant ones showed a remarkable increase in mRNA levels of Axl and ST6GalNAcII gene, and it was higher in malignant tumor cells than in borderline tumor cells. When ST6GalNAcII was silenced, compared to the control, the expression level of Axl was significantly reduced in malignant tumor cell transfectants and knockdown of ST6GalNAcII gene significantly inhibited invasive activity in malignant tumor cells. The high expression of ST6GalNAcII and Axl was significantly correlated with tumor grade and distance metastasis by immunohistochemical analysis. Axl and ST6GalNAcII expression increases with increasing tumor grade in mammary phyllodes tumors. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of PT cells.

  6. Research of 600C Grade Welding V-N Micro-Alloyed Steel Used on Truck Axle Housing After Thermal Forming

    Science.gov (United States)

    Quanli, Wang; Hui, Pan; Qingmei, Liu

    Automobile axle housing is the basic element to install the main reducing gear, differential mechanism, semi-axis, wheel hub and suspension. The main function of automobile axle housing is to support the automobile quality with driven axle, fix the driving wheel relative axial position and bear the driving wheel transmission force during the automobile running. Axle housing steel with the thickness of not less than 12mm is produced by the thermal forming method, which is to heat the plate to 830 degree and hold some time, then thermal forming, and cool to room temperature. The steel plate should maintain the original strength and good ductility and toughness requirements with thermal forming process.

  7. Heat-affected zone microstructure and mechanical properties evolution for laser remanufacturing 35CrMoA axle steel

    Science.gov (United States)

    Feng, Xiangyi; Dong, Shiyun; Yan, Shixing; Liu, Xiaoting; Xu, Binshi; Pan, Fusheng

    2018-03-01

    In this article, by using orthogonal test the technological test was conducted and the optimum processing of the remanufacturing35CrMoA axle were obtained. The evolution of microstructure and mechanical property of HAZ were investigated. The microstructure of HAZ was characterized by means of OM and SEM. Meanwhile hardness distribution in HAZ and tensile property of cladding-HAZ-substrate samples were measured. The microstructure of cladding and HAZ were observed. The microsturcture evoltion and the mechanism of harden in the HAZ was discussed and revealed. The results indicated that the remanufacturing part has excellent strength due to grain refining and dispersive distribution of nanoscale cementite. The remanufacturing part will have uniform microstructure and hardness matching with that of 35CrMoA axle by using stress-relieving annealing at 580°.

  8. Data analysis of heavy haul wagon axle loads on Malmbanan line, Sweden:A case study for LKAB

    OpenAIRE

    Lin, Janet; Nordmark, Thomas; Zhang, Liangwei

    2016-01-01

    The research presented in this report was carried out by Operation and Maintenance Engineering at Luleå University of Technology (LTU) from November 2015 to April 2016. LKAB initiated the research study and provided financial support. The purpose of this research was to support LKAB and Trafikverket in their operational strategy review and optimization of future axle load implementations. It developed five research questions and answered them by analyzing the data for the Malmbanan iron ore t...

  9. EEMD-Based Steady-State Indexes and Their Applications to Condition Monitoring and Fault Diagnosis of Railway Axle Bearings

    Directory of Open Access Journals (Sweden)

    Cai Yi

    2018-02-01

    Full Text Available Railway axle bearings are one of the most important components used in vehicles and their failures probably result in unexpected accidents and economic losses. To realize a condition monitoring and fault diagnosis scheme of railway axle bearings, three dimensionless steadiness indexes in a time domain, a frequency domain, and a shape domain are respectively proposed to measure the steady states of bearing vibration signals. Firstly, vibration data collected from some designed experiments are pre-processed by using ensemble empirical mode decomposition (EEMD. Then, the coefficient of variation is introduced to construct two steady-state indexes from pre-processed vibration data in a time domain and a frequency domain, respectively. A shape function is used to construct a steady-state index in a shape domain. At last, to distinguish normal and abnormal bearing health states, some guideline thresholds are proposed. Further, to identify axle bearings with outer race defects, a pin roller defect, a cage defect, and coupling defects, the boundaries of all steadiness indexes are experimentally established. Experimental results showed that the proposed condition monitoring and fault diagnosis scheme is effective in identifying different bearing health conditions.

  10. Faults Diagnostics of Railway Axle Bearings Based on IMF’s Confidence Index Algorithm for Ensemble EMD

    Directory of Open Access Journals (Sweden)

    Cai Yi

    2015-05-01

    Full Text Available As train loads and travel speeds have increased over time, railway axle bearings have become critical elements which require more efficient non-destructive inspection and fault diagnostics methods. This paper presents a novel and adaptive procedure based on ensemble empirical mode decomposition (EEMD and Hilbert marginal spectrum for multi-fault diagnostics of axle bearings. EEMD overcomes the limitations that often hypothesize about data and computational efforts that restrict the application of signal processing techniques. The outputs of this adaptive approach are the intrinsic mode functions that are treated with the Hilbert transform in order to obtain the Hilbert instantaneous frequency spectrum and marginal spectrum. Anyhow, not all the IMFs obtained by the decomposition should be considered into Hilbert marginal spectrum. The IMFs’ confidence index arithmetic proposed in this paper is fully autonomous, overcoming the major limit of selection by user with experience, and allows the development of on-line tools. The effectiveness of the improvement is proven by the successful diagnosis of an axle bearing with a single fault or multiple composite faults, e.g., outer ring fault, cage fault and pin roller fault.

  11. EEMD-Based Steady-State Indexes and Their Applications to Condition Monitoring and Fault Diagnosis of Railway Axle Bearings.

    Science.gov (United States)

    Yi, Cai; Wang, Dong; Fan, Wei; Tsui, Kwok-Leung; Lin, Jianhui

    2018-02-27

    Railway axle bearings are one of the most important components used in vehicles and their failures probably result in unexpected accidents and economic losses. To realize a condition monitoring and fault diagnosis scheme of railway axle bearings, three dimensionless steadiness indexes in a time domain, a frequency domain, and a shape domain are respectively proposed to measure the steady states of bearing vibration signals. Firstly, vibration data collected from some designed experiments are pre-processed by using ensemble empirical mode decomposition (EEMD). Then, the coefficient of variation is introduced to construct two steady-state indexes from pre-processed vibration data in a time domain and a frequency domain, respectively. A shape function is used to construct a steady-state index in a shape domain. At last, to distinguish normal and abnormal bearing health states, some guideline thresholds are proposed. Further, to identify axle bearings with outer race defects, a pin roller defect, a cage defect, and coupling defects, the boundaries of all steadiness indexes are experimentally established. Experimental results showed that the proposed condition monitoring and fault diagnosis scheme is effective in identifying different bearing health conditions.

  12. Faults Diagnostics of Railway Axle Bearings Based on IMF’s Confidence Index Algorithm for Ensemble EMD

    Science.gov (United States)

    Yi, Cai; Lin, Jianhui; Zhang, Weihua; Ding, Jianming

    2015-01-01

    As train loads and travel speeds have increased over time, railway axle bearings have become critical elements which require more efficient non-destructive inspection and fault diagnostics methods. This paper presents a novel and adaptive procedure based on ensemble empirical mode decomposition (EEMD) and Hilbert marginal spectrum for multi-fault diagnostics of axle bearings. EEMD overcomes the limitations that often hypothesize about data and computational efforts that restrict the application of signal processing techniques. The outputs of this adaptive approach are the intrinsic mode functions that are treated with the Hilbert transform in order to obtain the Hilbert instantaneous frequency spectrum and marginal spectrum. Anyhow, not all the IMFs obtained by the decomposition should be considered into Hilbert marginal spectrum. The IMFs’ confidence index arithmetic proposed in this paper is fully autonomous, overcoming the major limit of selection by user with experience, and allows the development of on-line tools. The effectiveness of the improvement is proven by the successful diagnosis of an axle bearing with a single fault or multiple composite faults, e.g., outer ring fault, cage fault and pin roller fault. PMID:25970256

  13. Heat-affected zone microstructure and mechanical properties evolution for laser remanufacturing LZ50 axle steel

    Science.gov (United States)

    Feng, Xiangyi; Dong, Shiyun; Fang, Jinxiang; Yan, Shixing; Xu, Binshi; Pan, Fusheng

    2017-10-01

    In this article, the laser cladding on LZ50 axle steel was conducted to investigate the evolution of microstructure and mechanical property of HAZ. Based on the quality of cladding formation and thermal damage evaluation in the HAZ, the optimal process parameters was obtained as 7.8g/min powder feeding rate,420mm/min scanning rate and other constant settings. The microstructure of HAZ was characterized by means of OM and SEM. Meanwhile hardness distribution in HAZ and tensile property of cladding-HAZ-substrate samples were measured. The results indicate that, Two types of HAZs were observed under different cladding strategies: gradually changed microstructure during thin-layer cladding process and relatively uniform microstructure during multi-layer cladding process..Due to different maximum temperature of thermal cycle, HAZ and substrate have partial surface hardening during the laser cladding process. The mechanism of hardening was discussed. The final microstructure after complex thermal cycles result hardening behavior in both HAZ and substrate.

  14. Acceleration Slip Regulation Strategy for Distributed Drive Electric Vehicles with Independent Front Axle Drive Motors

    Directory of Open Access Journals (Sweden)

    Lingfei Wu

    2015-05-01

    Full Text Available This paper presents an acceleration slip regulation strategy for distributed drive electric vehicles with two motors on the front axle. The tasks of the strategy include controlling the slip ratio to make full use of the road grip and controlling the yaw rate to eliminate the lateral movement due to the difference between motor torques. The rate of the slip ratio change can be controlled by controlling the motor torque, so that the slip ratio can be controlled by applying a proportional-integral control strategy to control the rate of the slip ratio change. The yaw rate can be controlled to almost zero by applying torque compensation based on yaw rate feedback. A coordination control strategy for the slip ratio control and yaw rate control is proposed based on analysis of the priorities and features of the two control processes. Simulations were carried out using MATLAB/Simulink, and experiments were performed on a hardware-in-loop test bench with actual motors. The results of the simulations and experiments showed that the proposed strategy could improve the longitudinal driving performance and straight line driving stability of the vehicle.

  15. Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

    Directory of Open Access Journals (Sweden)

    Peng Cheng

    2015-05-01

    Full Text Available Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs were recently identified: mesenchymal (MES and proneural (PN. To identify mechanisms to target the more aggressive MES GSCs, we combined transcriptomic expression analysis and kinome-wide short hairpin RNA screening of MES and PN GSCs. In comparison to PN GSCs, we found significant upregulation and phosphorylation of the receptor tyrosine kinase AXL in MES GSCs. Knockdown of AXL significantly decreased MES GSC self-renewal capacity in vitro and inhibited the growth of glioblastoma patient-derived xenografts. Moreover, inhibition of AXL with shRNA or pharmacologic inhibitors also increased cell death significantly more in MES GSCs. Clinically, AXL expression was elevated in the MES GBM subtype and significantly correlated with poor prognosis in multiple cancers. In conclusion, we identified AXL as a potential molecular target for novel approaches to treat glioblastoma and other solid cancers.

  16. Differential expression of the ufo/axl oncogene in human leukemia-lymphoma cell lines.

    Science.gov (United States)

    Challier, C; Uphoff, C C; Janssen, J W; Drexler, H G

    1996-05-01

    The ufo protein (also termed axl) is a member of a new family of receptor tyrosine kinases and is encoded by a transforming gene that was initially isolated from primary human myeloid leukemia cells by DNA-mediated transformation of NIH/3T3 cells. The ligand, Gas6, a protein S-related molecule lacking any known function yet, has recently been identified. We report the expression pattern of ufo mRNA in a panel of 76 human continuous leukemia-lymphoma cell lines. The gene was not expressed in cell lines derived from lymphoid malignancies (n=28), but transcription was seen in 3/11 myeloid, 0/6 monocytic, 9/13 erythroid and 11/18 megakaryocytic cell lines. Several cell lines were treated with phorbol ester leading to significant upregulation of the ufo message in constitutively positive cells. An apparent ufo mRNA overexpression was not found in any of the positive leukemia cell lines, but was identified in the drug-resistant subclones of the cervix carcinoma cell line HeLa. Southern blot analysis of restriction enzyme-digested genomic DNA did not provide evidence for gene amplification, but the HeLa subclones showed banding patterns suggestive of gene rearrangement. Two main ufo mRNA bands of 3.2 and 5.0 kb were identified; no differences in the half-lives (t1/2 = 2.5 h) of these two mRNA species could be identified. In summary, ufo, representing a novel type of receptor tyrosine kinase, is expressed solely in myeloid and erythro-megakaryocytic leukemias but not in lymphoid malignancies. These and previous data suggest an involvement of the ufo receptor tyrosine kinase in normal and malignant myelopoiesis; however, its exact role, if any, and mode of operation in leukemogenesis remains to be determined.

  17. Control of A Five-axle, Three-steering Coupled-vehicle System

    Science.gov (United States)

    Yamaguchi, Hiroaki; Mori, Masato; Kawakami, Atsushi

    This paper presents a new type of coupled-vehicle system: a five-axle, three-steering coupled-vehicle system and its path following feedback control law. The coupled-vehicle system consists of two car-like mobile robots, two carriers and a steering system. One of the two car-like mobile robots is coupled by one of the two carriers via a revolute joint passively rotating and the other car-like mobile robot is also coupled by one remaining carrier via a passive revolute joint, and the two carriers are coupled via another passive revolute joint. The steering system is attached to one of the carriers and its steering axis is located at the same position of the rotating axis of the passive revolute joint coupling the two carriers. We first show that, by assuming virtual mechanical elements, it is possible to convert the kinematical equation of the coupled-vehicle system into three-chain, single-generator chained form in a coordinate system in which a path two times differentiable is an axis and a straight line perpendicular to the tangent of the path is another axis. Based on chained form, we secondly derive the path following feedback control law which enables the orientations of the two carriers relative to the tangent of the path to be controllable. By the feedback control law, it is possible to cause the two carriers to form a line-shaped composed carrier or a V-shaped composed carrier and to cause them to keep such shapes while performing a path following behavior, which means that the coupled-vehicle system is able to adapt the shape of the composed carrier to the shape of a transported object. The validity of the mechanical design of the coupled-vehicle system and its path following feedback control law has been verified experimentally.

  18. PROSTAGLANDIN E2 INDUCES ONCOSTATIN M EXPRESSION IN HUMAN CHRONIC WOUND MACROPHAGES THROUGH AXL RECEPTOR TYROSINE KINASE PATHWAY1

    Science.gov (United States)

    Ganesh, Kasturi; Das, Amitava; Dickerson, Ryan; Khanna, Savita; Parinandi, Narasimham L.; Gordillo, Gayle M.; Sen, Chandan K.; Roy, Sashwati

    2012-01-01

    SUMMARY Monocytes and macrophages (mϕ) are plastic cells whose functions are governed by microenvironmental cues. Wound fluid bathing the wound tissue reflects the wound microenvironment. Current literature on wound inflammation is primarily based on the study of blood monocyte-derived mϕ (MDM), cells that have never been exposed to the wound microenvironment. We sought to pair-match compare MDMs with mϕ isolated from chronic wound of patients. Oncostatin M (OSM) was differentially overexpressed in pair-matched wound mϕ. Both PGE2 and its metabolite 13,14-dihydro-15-keto-PGE2 (PGE-M) were abundant in wound fluid and induced OSM in wound-site mϕ. Consistently, induction of OSM mRNA was observed in mϕ isolated from PGE2–enriched PVA sponges implanted in murine wounds. Treatment of human THP-1 cell-derived mϕ with PGE2 or PGE-M caused dose-dependent induction of OSM. Characterization of the signal transduction pathways demonstrated the involvement of EP4 receptor and cAMP signaling. In human mϕ, PGE2 phosphorylated Axl, a receptor tyrosine kinase (RTK). Axl phosphorylation was also induced by a cAMP analog demonstrating interplay between the cAMP and RTK pathways. PGE2–dependent Axl phosphorylation led to AP-1 transactivation which is directly implicated in inducible expression of OSM. Treatment of human mϕ or mice excisional wounds with recombinant OSM resulted in an anti-inflammatory response as manifested by attenuated expression of endotoxin-induced TNFα and IL-1β. OSM treatment also improved wound closure during the early inflammatory phase of healing. In summary this work recognizes PGE2 in the wound-fluid as a potent inducer of mϕ OSM, a cytokine with anti-inflammatory role in cutaneous wound healing. PMID:22844123

  19. Propiedades estructurales de ejes huecos y sólidos con una grieta plana//Structural proprieties of hollow and whole axles, with a flat crack

    Directory of Open Access Journals (Sweden)

    Jon‐Ariza De‐Miguel

    2014-05-01

    Full Text Available En este trabajo se estudiaron las diversas ventajas constructivas que los ejes huecos presentan respecto a los sólidos, como la reducción de masa, mejor control de calidad, menores defectos en producción y facilidad de acoplamiento. De ahí su profusión en aplicaciones industriales, como ejes de ferrocarril, de reductores o en calandrias. Dichas ventajas se ven alteradas cuando el eje trabaja a fatiga en flexión rotativa y aparece una grieta sobre el mismo. Se comprobaron dichas ventajas y sus variaciones sobre un modelo inicial de una grieta plana superficial, y se ha observado que los ejes huecos resultan más perjudicados por estas grietas para ciertos valores del diámetro interior, mientras que para otros son ventajosos. Se concluye del presente estudio que puede establecerse un rango de valores para el diámetro interior de ejes huecos en el cual su aprovechamiento seríaóptimo.Palabras claves: ejes huecos y sólidos, propiedades estructurales, grieta plana.______________________________________________________________________________AbstractThis work studies the several advantages hollow axles show when compared to whole ones, such as lightness, better quality control, less manufacturing defects, coupling simplicity. Thence their being profusely employed in industry, in applications like railway axles, gearboxes or calenders. Theseadvantages are altered when the axle works under bending with rotation under fatigue and a crack appears on its surface. An analytical research upon a flat surface crack model has been made of these advantages and their variations and it has been observed that hollow axles suffer more from these cracks than whole ones for certain inner diameter values, whereas for others even less than whole ones. It can be deduced that a gap for the inner diameter can be ascertained, where the axle´s rendering would be optimal.Key words: hollowand whole axles, structural properties, flat crack.

  20. Effect of Uphill Flexible Pavements on The Damaging Effect Of Full-Trailer Trucks With Tandem Front Axles

    Directory of Open Access Journals (Sweden)

    Sabah Said Razouki

    2017-08-01

    Full Text Available The effect of traffic on flexible pavements can be expressed in terms of truck equivalence factors. This paper presents a study on the effect of uphill pavements on the damaging effect (truck equivalence factors of two types of full-trailer trucks with tandem front axles. Axle load and geometrical characteristics survey on the two types of full-trailer trucks were carried out for determining the data needed in this study. In addition, uphill slope survey in Kerbala city was done and the data of uphill slope of other Iraqi cities were obtained from previous surveys. The paper reveals that the uphill pavement gradient causes significant increase in truck equivalence factors. In addition, the research reveals that there are many factors affecting the truck equivalence factors on uphill flexible pavements, including the total weight of full-trailer, H/B ratio (height of center of gravity to the wheel base of the truck, magnitude of uphill slope, and the structural number (SN.This work shows the importance of considering the effect of uphill slope in the design of flexible pavements on steep uphill slopes.

  1. Hopf Bifurcation Characteristics of Dual-Front Axle Self-Excited Shimmy System for Heavy Truck considering Dry Friction

    Directory of Open Access Journals (Sweden)

    Daogao Wei

    2015-01-01

    Full Text Available Multiaxle steering is widely used in commercial vehicles. However, the mechanism of the self-excited shimmy produced by the multiaxle steering system is not clear until now. This study takes a dual-front axle heavy truck as sample vehicle and considers the influences of mid-shift transmission and dry friction to develop a 9 DOF dynamics model based on Lagrange’s equation. Based on the Hopf bifurcation theorem and center manifold theory, the study shows that dual-front axle shimmy is a self-excited vibration produced from Hopf bifurcation. The numerical method is adopted to determine how the size of dry friction torque influences the Hopf bifurcation characteristics of the system and to analyze the speed range of limit cycles and numerical characteristics of the shimmy system. The consistency of results of the qualitative and numerical methods shows that qualitative methods can predict the bifurcation characteristics of shimmy systems. The influences of the main system parameters on the shimmy system are also discussed. Improving the steering transition rod stiffness and dry friction torque and selecting a smaller pneumatic trail and caster angle can reduce the self-excited shimmy, reduce tire wear, and improve the driving stability of vehicles.

  2. A Study on the Dynamic Interaction between Three-Axle Vehicle and Continuous Girder Bridge with Consideration of Braking Effects

    Directory of Open Access Journals (Sweden)

    Xuan-Toan Nguyen

    2017-01-01

    Full Text Available Continuous girder bridges become increasingly popular because of the rapid development of highway throughout the world. Most of previous researches on vibration analysis of a multispan continuous bridge subject to complex traffic loading and vehicle dynamic interaction focus on the girder displacement not considering braking effects. In current literature, few studies have discussed the effects of braking on continuous girder bridges. In this study, we employ the finite element method (FEM to investigate the dynamic response of continuous girder bridge due to three-axle vehicle. Vertical reaction forces of axles that change with time make bending vibration of girder increase significantly. The braking in the first span is able to create response in other spans. In addition, the dynamic impact factors are investigated by both FEM and experiments on a real bridge structure. The results of this study extend the current understanding of the bridge dynamic behaviors and can be used as additional references for bridge codes by practicing engineers.

  3. AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XIX, I--ENGINE TUNE-UP--CUMMINS DIESEL ENGINE, II--FRONT END SUSPENSION AND AXLES.

    Science.gov (United States)

    Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

    THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF DIESEL ENGINE TUNE-UP PROCEDURES AND THE DESIGN OF FRONT END SUSPENSION AND AXLES USED ON DIESEL ENGINE EQUIPMENT. TOPICS ARE (1) PRE-TUNE-UP CHECKS, (2) TIMING THE ENGINE, (3) INJECTOR PLUNGER AND VALVE ADJUSTMENTS, (4) FUEL PUMP ADJUSTMENTS ON THE ENGINE (PTR AND PTG),…

  4. Control allocation for for regenerative braking of electric vehicles with an electric motor at the front axle using the state-dependent Riccati equation control technique

    NARCIS (Netherlands)

    Kanarachos, S.A.; Alirezaei, M.; Jansen, S.T.H.; Maurice, J.P.

    2014-01-01

    In this paper the systematic development of an integrated braking controller for a vehicle driven by an electric motor on the front axle is presented. The objective is to engage the electric motor only during braking, up to the point at which the vehicle reaches its manoeuvrability and stability

  5. Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor

    Directory of Open Access Journals (Sweden)

    Guang-ju Zhao

    2017-01-01

    Full Text Available Background. Growth arrest-specific (Gas 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk, and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs are essential for the active suppression of autoimmunity. The present study was designed to investigate whether Tregs express TAM receptors and the potential role of Gas6-TAM signal in regulating the suppressive function of Tregs. Methods. The protein and mRNA levels of TAM receptors were determined by using Western blot, immunofluorescence, flow cytometry, and RT-PCR. Then, TAM receptors were silenced using targeted siRNA or blocked with specific antibody. The suppressive function of Tregs was assessed by using a CFSE-based T cell proliferation assay. Flow cytometry was used to determine the expression of Foxp3 and CTLA4 whereas cytokines secretion levels were measured by ELISA assay. Results. Tregs express both Axl and Mertk receptors. Gas6 increases the suppressive function of Tregs in vitro and in mice. Both Foxp3 and CTLA-4 expression on Tregs are enhanced after Gas6 stimulation. Gas6 enhances the suppressive activity of Tregs mainly through Axl receptor. Conclusion. Gas6 has a direct effect on the functions of CD4+CD25+Tregs mainly through its interaction with Axl receptor.

  6. Adaptive regenerative braking for electric vehicles with an electric motor at the front axle using the state dependent Riccati equation control technique

    NARCIS (Netherlands)

    Jansen, S.; Alirezaei, M.; Kanarachos, S.

    2014-01-01

    In this paper a novel adaptive regenerative braking control concept for electric vehicles with an electric motor at the front axle is presented. It is well known that the "phased" type regenerative braking systems of category B maximize the amount of regenerative energy during braking. However,

  7. Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

    International Nuclear Information System (INIS)

    Yeh, Chen-Yun; Tseng, Vincent S; Lee, Yuan-Chii G; Shen, Cheng-Huang; Chow, Nan-Haw; Liu, Hsiao-Sheng; Shin, Shin-Mei; Yeh, Hsuan-Heng; Wu, Tsung-Jung; Shin, Jyh-Wei; Chang, Tsuey-Yu; Raghavaraju, Giri; Lee, Chung-Ta; Chiang, Jung-Hsien

    2011-01-01

    A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers. Both NIH-Met5 and T24-Met3 cell lines harboring an inducible human c-Met gene were established. C-Met-related RTKs were screened by RTK microarray analysis. The cross-talk of RTKs was demonstrated by Western blotting and confirmed by small interfering RNA (siRNA) silencing, followed by elucidation of the underlying mechanism. The impact of this cross-talk on biological function was demonstrated by Trans-well migration assay. Finally, the potential clinical importance was examined in a cohort of 65 cases of locally advanced and metastatic bladder cancer patients. A positive association of Axl or platelet-derived growth factor receptor-alpha (PDGFR-α) with c-Met expression was demonstrated at translational level, and confirmed by specific siRNA knock-down. The transactivation of c-Met on Axl or PDGFR-α in vitro was through a ras- and Src-independent activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) pathway. In human bladder cancer, co-expression of these RTKs was associated with poor patient survival (p < 0.05), and overexpression of c-Met/Axl/PDGFR-α or c-Met alone showed the most significant correlation with poor survival (p < 0.01). In addition to c-Met, the cross-talk with Axl and/or PDGFR-α also contributes to the progression of human bladder cancer. Evaluation of Axl and PDGFR-α expression status may identify a subset of c-Met-positive bladder cancer patients who may require co-targeting therapy

  8. Shifting Control Algorithm for a Single-Axle Parallel Plug-In Hybrid Electric Bus Equipped with EMT

    Directory of Open Access Journals (Sweden)

    Yunyun Yang

    2014-01-01

    Full Text Available Combining the characteristics of motor with fast response speed, an electric-drive automated mechanical transmission (EMT is proposed as a novel type of transmission in this paper. Replacing the friction synchronization shifting of automated manual transmission (AMT in HEVs, the EMT can achieve active synchronization of speed shifting. The dynamic model of a single-axle parallel PHEV equipped with the EMT is built up, and the dynamic properties of the gearshift process are also described. In addition, the control algorithm is developed to improve the shifting quality of the PHEV equipped with the EMT in all its evaluation indexes. The key techniques of changing the driving force gradient in preshifting and shifting compensation phases as well as of predicting the meshing speed in the gear meshing phase are also proposed. Results of simulation, bench test, and real road test demonstrate that the proposed control algorithm can reduce the gearshift jerk and the power interruption time noticeably.

  9. A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

    Science.gov (United States)

    Jacob, A N; Kalapurakal, J; Davidson, W R; Kandpal, G; Dunson, N; Prashar, Y; Kandpal, R P

    1999-01-01

    We have used a modified differential display PCR protocol for isolating 3' restriction fragments of cDNAs specifically expressed or overexpressed in metastatic prostate carcinoma cell line DU145. Several cDNA fragments were identified that matched to milk fat globule protein, UFO/Axl, a receptor tyrosine kinase, human homologue of a Xenopus maternal transcript, laminin and laminin receptor, human carcinoma-associated antigen, and some expressed sequence tags. The transcript for milk fat globule protein, a marker protein shown to be overexpressed in breast tumors, was elevated in DU145 cells. The expression of UFO/Axl, a receptor tyrosine kinase, was considerably higher in DU145 cells as compared to normal prostate cells and prostatic carcinoma cell line PC-3. The overexpression of UFO oncogene in DU145 cells is discussed in the context of prostate cancer metastasis.

  10. Why is it so difficult to determine the lateral Position of the Rails by a Measurement of the Motion of an Axle on a moving Vehicle?

    DEFF Research Database (Denmark)

    True, Hans; Christiansen, Lasse Engbo

    2017-01-01

    Several attempts of measuring the exact location of the rails by the use of ordinary vehicles have been made. While the method works reasonably well in the vertical direction, the results of the lateral measurements made with different vehicles are so widely scattered that it is virtually...... impossible to draw any conclusions. We may therefore ask: does a wheel set follow the track disturbances exactly? In this article we investigate the lateral dynamics of a half-car vehicle model with two-axle bogies running on a rigid tangent track with sinusoidal lateral disturbances of the rails....... The wavelength, the amplitude and the phase between the rail disturbances are varied. Two different vehicle speeds are investigated. One speed is under and the other above the vehicle critical speed. In the article we show examples of axle motions that do not follow the track disturbances in phase, amplitude...

  11. The radial hardness-profile and the microstructure of railroad car axle materials treated by surface rolling, determined by novel examination methods

    International Nuclear Information System (INIS)

    Berecz, Tibor; Balogh, Levente; Mészáros, István; Steinbach, Ágoston

    2014-01-01

    Surface rolling is a cold-working technique used for hardening the surface of steel and ductile cast iron components. This process increases the surface hardness and improves the fatigue properties of components, so it is commonly used to treat railroad car wheel axles. The present paper examines the influence of this surface strengthening technique on the microstructure of the railroad car wheel axle material by hardness tests, optical microscopy (OM), and other novel examination methods, such as scanning electron microscopy (SEM), X-ray line profile analysis (XLPA), non-destructive magnetic evaluation (NDE) and automated electron backscatter diffraction (EBSD). The results show that surface rolling causes an increase in hardness down to a depth of ∼10 mm. It is also shown, that the increase in hardness is not due to grain refinement or change in grain morphology; thus it is likely to be caused by an increase in dislocation density

  12. Vibration levels on rear and front axles of a tractor in agricultural operations - doi: 10.4025/actascitechnol.v36i1.18170

    Directory of Open Access Journals (Sweden)

    Geice Paula Villibor

    2014-01-01

    Full Text Available Excessive vibrations in agricultural tractors can contribute with mechanical failures and subject the operator to discomfort. This work evaluated the vibration levels on rear and front axles of an agricultural tractor working at different forward speeds and wheel drive conditions in plowing and harrowing operations. Field tests were carried out in a completely randomized design in a factorial arrangement 3 x 2 (forward travel speeds x front-wheel-assist enable or disable, with three replications. Tractor vibration was measured using two single axis accelerometers fixed above the rear and front axles. The actual forward speed of the tractor was obtained by means of ultrasonic radar and the angular velocity of the wheels was measured with magnetic transducers. The drawbar force to pull the disc harrow was obtained by a load cell. The results showed that the vibration levels observed for the plowing operation were higher than observed for the harrowing operation. When the front-wheel-assist (FWA was enabled there was a reduction in vertical vibration levels of the tractor axles. The highest vibration levels were observed in the frequency range of 2 to 4Hz for the both soil tillage operations evaluated

  13. Effect of the load of drive axles and high of the curtain on stress-strain properties of the tractor

    Directory of Open Access Journals (Sweden)

    Tomáš Šmerda

    2007-01-01

    Full Text Available The goal of the experimental measurement was determination of relation among weight load of the tractor together, hitch height changes and drawbar characteristic. The measurement was realized on chassis dynamometer at MUAF in Brno. The first step consisted of rated speed characteristics measurement in conformity with OECD demands. The drawbar characteristic was measured under two selected gears. Adding 980 kg to the nominal wight of the tractor brought increasing maximal drawbar power and drawbar force together with decreasing of slip. The highest differences were observed during the mesurement of fifth gear shifted. The drawbar force grew up to 18.9% as well as the maximal drawbar power (15.2%. The maximal drawbar power at ninth gear gave 62.8 kW. The hitch height was setting to 0.54 m; 0.64 m and 0.74 m. When the hitch height was set from 0.54 m to 0.74 m the drawbar force an power on front axle was lower by reason of load reduction. As can be noticed from the final drawbar characteristics, both curves are identical up to border of maximal drawbar power. Small differences in the area of the highest slips can be ascribed to the rolling resistance.

  14. The Effect of Flexible Pavement Mechanics on the Accuracy of Axle Load Sensors in Vehicle Weigh-in-Motion Systems.

    Science.gov (United States)

    Burnos, Piotr; Rys, Dawid

    2017-09-07

    Weigh-in-Motion systems are tools to prevent road pavements from the adverse phenomena of vehicle overloading. However, the effectiveness of these systems can be significantly increased by improving weighing accuracy, which is now insufficient for direct enforcement of overloaded vehicles. Field tests show that the accuracy of Weigh-in-Motion axle load sensors installed in the flexible (asphalt) pavements depends on pavement temperature and vehicle speeds. Although this is a known phenomenon, it has not been explained yet. The aim of our study is to fill this gap in the knowledge. The explanation of this phenomena which is presented in the paper is based on pavement/sensors mechanics and the application of the multilayer elastic half-space theory. We show that differences in the distribution of vertical and horizontal stresses in the pavement structure are the cause of vehicle weight measurement errors. These studies are important in terms of Weigh-in-Motion systems for direct enforcement and will help to improve the weighing results accuracy.

  15. Cost-benefit analysis of the construction of different flexible pavement structures considering the axle load and type of binder

    Directory of Open Access Journals (Sweden)

    Lucas Dotto Bueno

    2016-08-01

    Full Text Available The status of Brazilian highways reflects a deficient pavement performance when they are subjected to loadings imposed by heavy traffic. Current legislation, as enacted by Contran (National Traffic Council, has increased the axle weight limit for cargo vehicles by up to 10%. Therefore, the aim of this study was to determine a cost-benefit ratio by using different types of structures, asphalt binders and load intensities. Typical pavements were determined and then analyzed by the software AEMC (SisPav to obtain the horizontal tensile strain (εt values at the bottom of the asphalt concrete layer and, later, the NFATIGUE value. It was found that the increase in weight, within values covered by legislation, might result in a reduction of approximately 50% in the NFATIGUE value for the pavement structures analyzed. As for economic impact, the same weight increase caused a mean increase of 120% in the cost of repeated loading on pavement structures (R$ NFATIGUE-1. It was also observed that structures with more robust asphalt concrete layers can provide the best R$ NFATIGUE-1 ratios. The best results for granular materials were found with thinner layers, associated with a thicker coating. The benefits of modified binders were shown by the analyses of the best structural options: both the polymer-modified binder and the rubber asphalt binder offer significant structural and economic improvements to the structure.

  16. Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis

    Directory of Open Access Journals (Sweden)

    Niki Karachaliou

    2018-03-01

    Full Text Available Epidermal growth factor receptor (EGFR-mutation-positive non-smallcell lung cancer (NSCLC is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs. We investigated receptor tyrosine kinases (RTKs, Src family kinases and focal adhesion kinase (FAK as genetic modifiers of innate resistance in EGFR-mutation-positive NSCLC. We performed gene expression analysis in two cohorts (Cohort 1 and Cohort 2 of EGFR-mutation-positive NSCLC patients treated with EGFR TKI. We evaluated the efficacy of gefitinib or osimertinib with the Src/FAK/Janus kinase 2 (JAK2 inhibitor, TPX0005 in vitro and in vivo. In Cohort 1, CUB domain-containing protein-1 (CDCP1 was an independent negative prognostic factor for progression-free survival (hazard ratio of 1.79, p = 0.0407 and overall survival (hazard ratio of 2.23, p = 0.0192. A two-gene model based on AXL and CDCP1 expression was strongly associated with the clinical outcome to EGFR TKIs, in both cohorts of patients. Our preclinical experiments revealed that several RTKs and non-RTKs, were up-regulated at baseline or after treatment with gefitinib or osimertinib. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing. Keywords: Lung cancer, EGFR, Resistance, AXL, CDCP1, Combination therapies

  17. Axle-sleeve Structured MWCNTs/Polyaniline Composite Film as Cost-effective Counter-Electrodes for High Efficient Dye-Sensitized Solar Cells

    International Nuclear Information System (INIS)

    Niu, Haihong; Qin, Shengxian; Mao, Xiaoli; Zhang, Shouwei; Wang, Renbao; Wan, Lei; Xu, Jinzhang; Miao, Shiding

    2014-01-01

    Graphical abstract: Axle-sleeve structured composite materials made with carbon nanotubes and polyaniline were prepared via a co-polymerization strategy. The composite materials were employed as cost-effective counter electrode modifier in dye-sensitized solar cells which demonstrate a comparable photo-to-electron conversion efficiency as the Pt catalyst. - Highlights: • Axle-sleeve structured MWCNT/PANI composite was prepared. • The optimum mass ratio of MWCNT/ANIranges between 1:3 and 1:1. • The π-π drive force was confirmed by spectroscopicmeans. • The polymerization time of 12∼24 hrs affords the highest conversion efficiency. • The DSSCs assembled with the MWCNTs/PANI CEs exhibit a comparable η(7.21%) as that with Pt CE (7.59%). - Abstract: Axle-sleeve structured composite materials made with multi-walled carbon nanotubes (MWCNTs) and polyaniline (PANI) were prepared, characterized, and employed as cost-effective counter electrodes (CEs) in dye-sensitized solar cells (DSSCs). The composite was synthesized by co-polymerization of aniline with carboxylated MWCNTs by using ammonium persulfate in the acidic medium. Thin films of MWCNTs/PANI were prepared via a spin coating technique followed by thermal treatment in N 2 atmosphere. The micro-structure of the composite was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) linked with energy dispersive spectroscopy (EDS). The coating layer of PANI on the MWCNTs and new-formed chemical bonds between MWCNTs and PANI was studied by UV-Vis absorption, X-ray photoelectron spectroscopy (XPS), Raman and FT-IR spectroscopic means. The effect of the multiple-level porosity or the axle-sleeve structures in the composite of MWCNTs/PANI on the electro-catalytic activity was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopic (EIS) analysis. The DSSCs assembled with MWCNTs/PANI as CEs exhibit a comparable energy conversion efficiency (η) of 7

  18. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

    Science.gov (United States)

    Braunger, J; Schleithoff, L; Schulz, A S; Kessler, H; Lammers, R; Ullrich, A; Bartram, C R; Janssen, J W

    1997-06-05

    Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) method. Three putative Ufo substrates were identified: phospholipase Cgamma1 (PLCgamma), as well as p85alpha and p85beta subunits of phosphatidylinositol 3'-kinase (PI3-kinase). Subsequently, chimeric EGFR/Ufo receptors consisting of the extracellular domains of the epidermal growth factor receptor (EGFR) and the transmembrane and intracellular moiety of Ufo were engineered. Using different far-Western blot analyses and coimmunoprecipitation assays, receptor binding of PLCgamma and p85 proteins as well as GRB2, c-src and lck was examined in vitro and in vivo. Competitive inhibition of substrate binding and mutagenesis experiments with EGFR/Ufo constructs revealed C-terminal tyrosine 821 (EILpYVNMDEG) as a docking site for multiple effectors, namely PLCgamma, p85 proteins, GRB2, c-src and lck. Tyrosine 779 (DGLpYALMSRC) demonstrated an additional, but lower binding affinity for the p85 proteins in vitro. In addition, binding of PLCgamma occurred through tyrosine 866 (AGRpYVLCPST). Moreover, our in vivo data indicate that further direct or indirect binding sites for PLCgamma, GRB2, c-src and lck on the human Ufo receptor may exist.

  19. ORNL-GM: Development of Ionic Liquid-Additized, GF-5/6 Compatible Low-Viscosity Oils for Automotive Engine and Rear Axle Lubrication for 4% Improved Fuel Economy

    Energy Technology Data Exchange (ETDEWEB)

    Qu, Jun [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Zhou, Yan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Luo, Huimin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Toops, Todd J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brookshear, Daniel W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stump, Benjamin C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Viola, Michael B. [General Motors (GM) Technical Center, Pontiac, MI (United States); Zreik, Khaled [General Motors (GM) Technical Center, Pontiac, MI (United States); Ahmed, Tasfia [General Motors (GM) Technical Center, Pontiac, MI (United States)

    2017-01-01

    The overall objective of this project are as follows: Further develop ionic liquid (IL)-additized lowviscosity engine oils meeting the GF-5/6 specifications and possessing superior lubricating characteristics; Expand the IL additive technology to rear axle lubricants; and Seek a combined improvement in the vehicle fuel economy

  20. THE LIFETIME EXTENSION OF CAR AXLES TYPES OF RU1 AND RUSH WHEELSET FREIGHT CARS, RESTORED BY THE METHOD OF PLASMA-ARC METALLIZATION OF THE NECK AND UNDER PARTS MANUAL

    Directory of Open Access Journals (Sweden)

    V. I. Zelenin

    2009-03-01

    Full Text Available The restoration method for the journals and wheel seats of the freight wagon wheelsets by means of plasma-arc metallization is presented and the results of the bench fatigue tests with the advisable operation life of the axles restored are given.

  1. Extended-Kalman-filter-based regenerative and friction blended braking control for electric vehicle equipped with axle motor considering damping and elastic properties of electric powertrain

    Science.gov (United States)

    Lv, Chen; Zhang, Junzhi; Li, Yutong

    2014-11-01

    Because of the damping and elastic properties of an electrified powertrain, the regenerative brake of an electric vehicle (EV) is very different from a conventional friction brake with respect to the system dynamics. The flexibility of an electric drivetrain would have a negative effect on the blended brake control performance. In this study, models of the powertrain system of an electric car equipped with an axle motor are developed. Based on these models, the transfer characteristics of the motor torque in the driveline and its effect on blended braking control performance are analysed. To further enhance a vehicle's brake performance and energy efficiency, blended braking control algorithms with compensation for the powertrain flexibility are proposed using an extended Kalman filter. These algorithms are simulated under normal deceleration braking. The results show that the brake performance and blended braking control accuracy of the vehicle are significantly enhanced by the newly proposed algorithms.

  2. Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis.

    Science.gov (United States)

    Karachaliou, Niki; Chaib, Imane; Cardona, Andres Felipe; Berenguer, Jordi; Bracht, Jillian Wilhelmina Paulina; Yang, Jie; Cai, Xueting; Wang, Zhigang; Hu, Chunping; Drozdowskyj, Ana; Servat, Carles Codony; Servat, Jordi Codony; Ito, Masaoki; Attili, Ilaria; Aldeguer, Erika; Capitan, Ana Gimenez; Rodriguez, July; Rojas, Leonardo; Viteri, Santiago; Molina-Vila, Miguel Angel; Ou, Sai-Hong Ignatius; Okada, Morihito; Mok, Tony S; Bivona, Trever G; Ono, Mayumi; Cui, Jean; Cajal, Santiago Ramón Y; Cao, Peng; Rosell, Rafael

    2018-03-01

    Epidermal growth factor receptor (EGFR)-mutation-positive non-smallcell lung cancer (NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs). We investigated receptor tyrosine kinases (RTKs), Src family kinases and focal adhesion kinase (FAK) as genetic modifiers of innate resistance in EGFR-mutation-positive NSCLC. We performed gene expression analysis in two cohorts (Cohort 1 and Cohort 2) of EGFR-mutation-positive NSCLC patients treated with EGFR TKI. We evaluated the efficacy of gefitinib or osimertinib with the Src/FAK/Janus kinase 2 (JAK2) inhibitor, TPX0005 in vitro and in vivo. In Cohort 1, CUB domain-containing protein-1 (CDCP1) was an independent negative prognostic factor for progression-free survival (hazard ratio of 1.79, p=0.0407) and overall survival (hazard ratio of 2.23, p=0.0192). A two-gene model based on AXL and CDCP1 expression was strongly associated with the clinical outcome to EGFR TKIs, in both cohorts of patients. Our preclinical experiments revealed that several RTKs and non-RTKs, were up-regulated at baseline or after treatment with gefitinib or osimertinib. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  3. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

    Science.gov (United States)

    Mark, M R; Scadden, D T; Wang, Z; Gu, Q; Goddard, A; Godowski, P J

    1994-04-08

    We have isolated cDNA clones that encode the human and murine forms of a novel receptor-type tyrosine kinase termed Rse. Sequence analysis indicates that human Rse contains 890 amino acids, with an extracellular region composed of two immunoglobulin-like domains followed by two fibronectin type III domains. Murine Rse contains 880 amino acids and shares 90% amino acid identity with its human counterpart. Rse is structurally similar to the receptor-type tyrosine kinase Axl/Ufo, and the two proteins have 35 and 63% sequence identity in their extracellular and intracellular domains, respectively. To study the synthesis and activation of this putative receptor-type tyrosine kinase, we constructed a version of Rse (termed gD-Rse, where gD represents glycoprotein D) that contains an NH2-terminal epitope tag. NIH3T3 cells were engineered to express gD-Rse, which could be detected at the cell surface by fluorescence-activated cell sorting. Moreover, gD-Rse was rapidly phosphorylated on tyrosine residues upon incubation of the cells with an antibody directed against the epitope tag, suggesting that rse encodes an active tyrosine kinase. In the human tissues we examined, the highest level of expression of rse mRNA was observed in the brain; rse mRNA was also detected in the premegakaryocytopoietic cell lines CMK11-5 and Dami. The gene for rse was localized to human chromosome 15.

  4. Comparative analysis of the operation efficiency of the continuous and relay control systems of a multi-axle wheeled vehicle suspension

    Science.gov (United States)

    Zhileykin, M. M.; Kotiev, G. O.; Nagatsev, M. V.

    2018-02-01

    In order to improve the efficiency of the multi-axle wheeled vehicles (MWV) automotive engineers are increasing their cruising speed. One of the promising ways to improve ride comfort of the MWV is the development of the dynamic active suspension systems and control laws for such systems. Here, by the dynamic control systems we mean the systems operating in real time mode and using current (instantaneous) values of the state variables. The aim of the work is to develop the MWV suspension optimal control laws that would reduce vibrations on the driver’s seat at kinematic excitation. The authors have developed the optimal control laws for damping the oscillations of the MWV body. The developed laws allow reduction of the vibrations on the driver’s seat and increase in the maximum speed of the vehicle. The laws are characterized in that they allow generating the control inputs in real time mode. The authors have demonstrated the efficiency of the proposed control laws by means of mathematical simulation of the MWV driving over unpaved road with kinematic excitation. The proposed optimal control laws can be used in the MWV suspension control systems with magnetorheological shock absorbers or controlled hydropneumatic springs. Further evolution of the research line can be the development of the energy-efficient MWV suspension control systems with continuous control input on the vehicle body.

  5. Ride comfort optimization of a multi-axle heavy motorized wheel dump truck based on virtual and real prototype experiment integrated Kriging model

    Directory of Open Access Journals (Sweden)

    Bian Gong

    2015-06-01

    Full Text Available The optimization of hydro-pneumatic suspension parameters of a multi-axle heavy motorized wheel dump truck is carried out based on virtual and real prototype experiment integrated Kriging model in this article. The root mean square of vertical vibration acceleration, in the center of sprung mass, is assigned as the optimization objective. The constraints are the natural frequency, the working stroke, and the dynamic load of wheels. The suspension structure for the truck is the adjustable hydro-pneumatic suspension with ideal vehicle nonlinear characteristics, integrated with elastic and damping elements. Also, the hydraulic systems of two adjacent hydro-pneumatic suspension are interconnected. Considering the high complexity of the engineering model, a novel kind of meta-model called virtual and real prototype experiment integrated Kriging is proposed in this article. The interpolation principle and the construction of virtual and real prototype experiment integrated Kriging model were elucidated. Being different from traditional Kriging, virtual and real prototype experiment integrated Kriging combines the respective advantages of actual test and Computer Aided Engineering simulation. Based on the virtual and real prototype experiment integrated Kriging model, the optimization results, obtained by experimental verification, showed significant improvement in the ride comfort by 12.48% for front suspension and 11.79% for rear suspension. Compared with traditional Kriging, the optimization effect was improved by 3.05% and 3.38% respectively. Virtual and real prototype experiment integrated Kriging provides an effective way to approach the optimal solution for the optimization of high-complexity engineering problems.

  6. Editor’s Pick: TYRO3, AXL, and MERTK Receptor Tyrosine Kinases: Is There Evidence of Direct Involvement in Development and Onset of Sjögren’s Syndrome?

    Directory of Open Access Journals (Sweden)

    Arun Wanchoo

    2016-07-01

    Full Text Available Sjögren’s syndrome (SjS is a chronic, progressive, systemic, human autoimmune disease in which an auto-inflammatory process within the salivary and lacrimal glands results in loss of saliva and tear production, respectively. In-depth analyses of the autoimmune process in humans and animal models of SjS substantiates one of the more important pathoaetiological pathways: an increased level of glandular apoptosis and/or cell lysis. We have hypothesised that failure in clearance of dying cells by macrophages, dendritic cells, and neighbouring tissues results in a sustained innate inflammatory response that transitions to autoimmunity. Since the intrinsic inhibition of inflammation following phagocytosis of dying cells is a function of a family of three receptor tyrosine kinases (RTKs known as the TAM (Tyro3, Axl, and Mertk, we put forward the following hypothesis: based on published information and analysis of our public microarray data, the failure of TAM RTK signalling, specifically in activating suppressor of cytokine signalling (SOCS 1 and SOCS3 (which are inhibitors of immune responses, may lead to autoimmunity, and specifically, to SjS-like disease.

  7. Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

    Directory of Open Access Journals (Sweden)

    Rihan El Bezawy

    2017-01-01

    Full Text Available Abstract Background The value of microRNAs (miRNAs as novel targets for cancer therapy is now widely recognized. However, no information is currently available on the expression/functional role of miRNAs in diffuse malignant peritoneal mesothelioma (DMPM, a rapidly lethal disease, poorly responsive to conventional treatments, for which the development of new therapeutic strategies is urgently needed. Here, we evaluated the expression and biological effects of miR-34a—one of the most widely deregulated miRNAs in cancer and for which a lipid-formulated mimic is already clinically available—in a large cohort of DMPM clinical samples and a unique collection of in house-developed preclinical models, with the aim to assess the potential of a miR-34a-based approach for disease treatment. Methods miR-34a expression was determined by qRT-PCR in 45 DMPM and 7 normal peritoneum specimens as well as in 5 DMPM cell lines. Following transfection with miR-34a mimic, the effects on DMPM cell phenotype, in terms of proliferative potential, apoptotic rate, invasion ability, and cell cycle distribution, were assessed. In addition, three subcutaneous and orthotopic DMPM xenograft models were used to examine the effect of miR-34a on tumorigenicity. The expression of miRNA targets and the activation status of relevant pathways were investigated by western blot. Results miR-34a was found to be down-regulated in DMPM clinical specimens and cell lines compared to normal peritoneal samples. miR-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL and the interference with the activation of downstream signaling. Interestingly, a persistent activation of ERK1/2 and AKT in miR-34a-reconstituted cells was found to counteract the antiproliferative and proapoptotic effects of miRNA, yet not affecting its anti

  8. Dynamic analysis of rail vehicle axle

    Indian Academy of Sciences (India)

    ... coach, suspension characteristics and way conditions have been examined. Dynamic forces found in the resonance regions at the range of 2–5 m/s (7.2–18 km/h) has been discussed. Theoretical results obtained for the dynamic forces have been successfully compared with the experimental results of German Railways ...

  9. Dynamic analysis of rail vehicle axle

    Indian Academy of Sciences (India)

    model of the train. Bayraktar et al (2009) have investigated the vertical motions of a light rail vehicle serving in ... time and frequency domains, a fuzzy logic controller is used to actively control vibrations in the simulation ... the front and rear bogie frames, vertical and horizontal motion and yawing angle of the four wheelset.

  10. Dynamic analysis of rail vehicle axle

    Indian Academy of Sciences (India)

    In order to analyse the behaviour of a suburban train equipped with a pneumatic secondary suspension, Docoquier et al (2007) obtained a complete model of the pneumatic circuit and coupled with a multibody model of the train. Bayraktar et al (2009) have investigated the vertical motions of a light rail vehicle serving in.

  11. Utilización del factor de densidad de energía de deformación en el modelo de crecimiento de la grieta en árboles de molinos de caña de azúcar. // Use of the density deformation energy factor in the crack growth pattern of sugar cane mills axles.

    Directory of Open Access Journals (Sweden)

    N. Arzola de la Peña

    2005-05-01

    Full Text Available En el trabajo se aplica el criterio de densidad de energía de deformación en el modelo de crecimiento de la grieta para losárboles de los molinos de caña de azúcar. La utilización de este criterio permite predecir no solamente la razón decrecimiento de las grietas sino también la inclinación que las mismas van experimentando durante su propagación, conrespecto al plano inicial donde surgen. Son modelados los dos tipos de grietas que usualmente ocurren en estos elementos,la grieta semielíptica superficial y la circunferencial. Se demuestra que la grieta circunferencial siempre crece en un planonormal al eje del árbol, mientras que las semielípticas lo harán en un plano algo inclinado en dependencia del predominiode las tensiones tangenciales. La grieta circunferencial resultó ser más crítica que la semielíptica superficial.Palabras claves: Energía de deformación, molinos de caña, propagación de grietas._______________________________________________________________________________Abstract.In this paper the approach of the density deformation energy factor in the crack growth pattern of sugar cane mills axles isapplied. The use of this approach allows predicting not only the rate of cracks growth but also the inclination that the sameones experienced during its propagation, with regard to the initial plane where they arise. The two types of cracks thatusually happens in these elements are modelled, the semielliptical superficial crack and the circumferential. It isdemonstrated that the circumferential crack always grows in a normal plane to the axis of the axle, while the semiellipticalwill make it in a plane something bowed in dependence of the prevalence of the tangential tensions. The circumferentialcrack turned out to be more critical than the semielliptical superficial.Keywords: Energy of deformation, cane mills, crack propagation.

  12. Will the requirement by the US FDA to simultaneously co-develop companion diagnostics (CDx delay the approval of receptor tyrosine kinase (RTK inhibitors for RTK-rearranged (ROS1-, RET-, AXL-, PDGFR-a-, NTRK1- non-small cell lung cancer globally?

    Directory of Open Access Journals (Sweden)

    Sai-Hong Ignatius Ou

    2014-04-01

    Full Text Available The discovery of anaplastic lymphoma kinase (ALK rearrangement in non-small cell lung cancer (NSCLC in 2007 and the approval of crizotinib for the treatment of advanced ALK-rearranged NSCLC in 2011 represents a landmark in the development of targeted oncology therapy. The approval of crizotinib was accompanied simultaneously by the approval of approval of the Vysis (Abbott Molecular break-apart fluorescence in situ hybridization test as the companion diagnostic (CDx test to detect ALK rearrangement. Pfizer, the manufacturer of crizotinib, sponsored the screening of thousands of patients and the standardization of the ALK FISH test as part of the approval process for crizotinib, a first in class ALK inhibitor. Many pharmaceutical companies are now using the FDA-approved ALK FISH assay to enroll patients onto trials for their own respective ALK inhibitors. In essence they are piggybacking on the FDA-approved ALK FISH assay without having to pay for the development of a CDx, nor screening for ALK-rearranged NSCLC patients in the protocols because screening for ALK rearrangement is now the standard of care in NSCLC after the approval of crizotinib. Since 2007, rearrangement in more RTKs such as ROS1, RET, AXL, PDGFR-α, and NTRK1 have been discovered in NSCLC but the incidence of each subtype of RTK-rearranged NSCLC is quite rare. Crizotinib has now demonstrated significant clinical activity in ROS1-rearranged NSCLC patients. Whether crizotinib will gain official FDA approval for use in ROS1-rearranged NSCLC, on the other hand, remains unclear as there is no test for ROS1 rearrangement currently being developed to support US FDA approval as a CDx. This may be due in part to the fact that the full cost associated with the development of a pre-market approved (PMA-approved CDx must be borne by the company seeking the first drug approval in a new indication. Given the low incidence of ROS1 rearrangement in NSCLC, and the availability of crizotinib in

  13. Optimization of Front Axle Suspension System of Articulated Dump Truck

    OpenAIRE

    Langer, Thomas Heegaard; Christensen, Brian B.; Mouritsen, Ole Ø.; Hansen, Michael Rygaard

    2010-01-01

    Manufacturers of construction machinery are challenged to accommodate legal requirements on the vibration exposure associated with their products. For such machines a crucial performance parameter is the whole body vibration level that the operator is subjected to.This paper presents results from ongoing research collaboration between Hydrema Produktion A/S, Aalborg University and the University of Agder on comfort improvement. The main goal of the research project is to improve ride comfort ...

  14. An appraisal of mass differences between individual tyres, axles and axle groups of a selection of heavy vehicles in South Africa

    CSIR Research Space (South Africa)

    De Beer, Morris

    2012-06-01

    Full Text Available In road design, accurate quantification of traffic loading remains a challenge. Research in South Africa with the Stress-In-Motion (SIM) system has concentrated on interaction forces between slow-moving tyres and the textured SIM device. A field...

  15. Heavy and overweight vehicle brake testing : combination six-axle, final report.

    Science.gov (United States)

    2017-05-01

    The Heavy and Overweight Vehicle Brake Testing (HOVBT) program exists in order to provide information about the effect of gross vehicle weight (GVW) and on braking performance testing included service brake stopping distance tests, constant-pressure ...

  16. Heavy and overweight vehicle brake testing : combination five-axle tractor-flatbed, final report

    Science.gov (United States)

    2017-05-01

    The Federal Motor Carrier Safety Administration (FMCSA), in coordination with the Federal Highway Administration (FHWA), sponsored the Heavy and Overweight Vehicle Brake Testing (HOVBT) program in order to provide information about the effect of gros...

  17. Optimization of Lightweight Axles for an Innovative Carving Skateboard Based on Carbon Fiber Placement

    Directory of Open Access Journals (Sweden)

    Marc Fleischmann

    2018-02-01

    Full Text Available In 2003, the BMW Group developed a longboard called “StreetCarver”. The idea behind this product was to bring the perfect carving feeling of surf- and snowboarding on the streets by increasing the maneuverability of classical skateboard trucks. The outcome was a chassis based on complex kinematics. The negative side effect was the StreetCarver’s exceptional high weight of almost 8 kg. The main reason for this heaviness was the choice of traditional metallic engineering materials. In this research, modern fiber reinforced composites were used to lower the chassis’ mass by up to 50% to reach the weight of a common longboard. To accomplish that goal, carbon fibers were placed along pre-simulated load paths of the structural components in a so-called Tailored- Fiber-Placement process. This technology allows an angle-independent single-roving placement and leads not only to the reduction of weight but also helps to save valuable fiber material by avoiding cutting waste.

  18. Information space is action space: perceiving the partial lengths of rods rotated on an axle.

    Science.gov (United States)

    Michaels, Claire F; Isenhower, Robert W

    2011-01-01

    In a single experiment, perceivers held unseen rods at some position along their lengths and reported the two partial lengths-to the left and to the right of the hand. Wielding was mechanically limited to a vertical plane. Previous research suggested that the information exploited for this task is captured in a space created from the moment of inertia and gravitational torque. The experiment reported here attempted to replicate the relevance of that space and to ask how exploration might access it. Perceivers were given feedback on accuracy on Blocks 2 and 3 of a four-block experiment, and their performance and position in information space were monitored. Exploratory movements were recorded. Judgments were shown to depend on inertial and gravitational torques, as expected. Analysis of exploratory movements suggested that occupying a locus in information space is equivalent to exploring at some angular acceleration. The apparent weighting of cues (gravitational and inertial torque), which might be interpreted as a cognitive process, was instead interpreted as a consequence of manner of exploration.

  19. Fatigue of bridges with a horizontal rotation axle under random wind load

    NARCIS (Netherlands)

    Maljaars, J.; Steenbergen, R.D.J.M.

    2012-01-01

    The operating mechanisms of movable bridges are subjected to various types of fluctuating loads which may induce fatigue damage. Wind load acting on the bridge deck - when the bridge is open - is one of the important load types. A wind load model is proposed that can be used in the fatigue design

  20. Analysis of the nonlinear dynamics of a 2-axle freight wagon in curves

    DEFF Research Database (Denmark)

    Di Gialleonardo, Egidio; Bruni, Stefano; True, Hans

    2014-01-01

    and bifurcations are identified for some particular values of the curve radius. For the single car case, it is shown that depending on the curve radius and the vehicle speed the carbody may experience severe periodic oscillations at speeds lying in the operating range of the vehicle. For the car-assembly case...

  1. Army Excellence in Leadership (AXL): Educating Army Leaders with the Tripwire Film

    Science.gov (United States)

    2007-03-01

    evident is the internal conflict suffered by I LT Porter after finding out about his girlfriend’s pregnancy . I LT Porter’s internal conflict manifested...Relationship or interpersonal conflict is evident between ILT Porter and lSG Morino, while the news of his girlfriend’s pregnancy also triggers an...the one in the doorway. At that time the male with the book bag of prayer books appears on a roof aiming an RPG launcher at the Iraqi official’s car. I

  2. Development of an Army Stationary Axle Efficiency Test Stand - Interim Report TFLRF No. 471

    Science.gov (United States)

    2015-09-01

    INSTITUTE QUALIFIED PRODUCTS LIST Company Name Address Expiration Date PRI QPL # Brand Name SAE Viscosity Grade Petronas Lubricants Italy S.P.A. Via...Santena 1 10029 Villastellone (TO) Italy 30-Sep-18 PRI GL 0631 Tutela Transmission Stargear AX-ED SAE 75W-90 Petronas Lubricants Italy S.P.A. Via...Santena 1 10029 Villastellone (TO) Italy 31-Jul-18 PRI GL 0632 Tutela Transmission X-Road SAE 75W-90 Petronas Lubrificantes Brasil S.A. Avenida Trajano de

  3. Monitoring bolt tightness of rail joints using axle box acceleration measurements

    NARCIS (Netherlands)

    Oregui Echeverria-Berreyarza, M.; Li, S.; Li, Z.; Carroll, R; Dollevoet, R.P.B.J.

    2016-01-01

    Rail joints are a weak component in railway tracks because of the large impact and wheel-rail contact forces. Every train passage contributes to the deterioration of rail joints, causing visible (e.g. battered rails) and invisible (e.g. loose bolts) damages. The invisible damage cannot be detected

  4. Army Excellence in Leadership (AXL): Educating Army Leaders with the Tripwire Film

    National Research Council Canada - National Science Library

    Metcalf, Kimberly A; Zbylut, Michelle L

    2007-01-01

    ...) system within a traditional classroom setting. The manual is intended to help instructors prepare for classroom discussions of leadership challenges and issues embedded within the Tripwire scenario...

  5. Plugging a Bipyridinium Axle into Multichromophoric Calix[6]arene Wheels Bearing Naphthyl Units at Different Rims.

    Science.gov (United States)

    Orlandini, Guido; Ragazzon, Giulio; Zanichelli, Valeria; Degli Esposti, Lorenzo; Baroncini, Massimo; Silvi, Serena; Venturi, Margherita; Credi, Alberto; Secchi, Andrea; Arduini, Arturo

    2017-02-01

    Tris-( N -phenylureido)-calix[6]arene derivatives are heteroditopic non-symmetric molecular hosts that can form pseudorotaxane complexes with 4,4'-bipyridinium-type guests. Owing to the unique structural features and recognition properties of the calix[6]arene wheel, these systems are of interest for the design and synthesis of novel molecular devices and machines. We envisaged that the incorporation of photoactive units in the calixarene skeleton could lead to the development of systems the working modes of which can be governed and monitored by means of light-activated processes. Here, we report on the synthesis, structural characterization, and spectroscopic, photophysical, and electrochemical investigation of two calix[6]arene wheels decorated with three naphthyl groups anchored to either the upper or lower rim of the phenylureido calixarene platform. We found that the naphthyl units interact mutually and with the calixarene skeleton in a different fashion in the two compounds, which thus exhibit a markedly distinct photophysical behavior. For both hosts, the inclusion of a 4,4 ' -bipyridinium guest activates energy- and/or electron-transfer processes that lead to non-trivial luminescence changes.

  6. Performance of Single Axle Tractors in the Semi-Arid Central Part of ...

    African Journals Online (AJOL)

    user1

    intensification of subsistence agricultural production associated with increased power utilization. In this ... Laike and Bisrat. [39]. Two- wheel tractor also known as a power tiller, walking tractor, hand tractor or garden ..... meeting the requirements like soil tillage in areas where there is hard black soils and other favorable ...

  7. Algorithm of orthogonal bi-axle for auto-separating of watermelon seeds

    Science.gov (United States)

    Sun, Yong; Guan, Miao; Yu, Daoqin; Wang, Jing

    2007-11-01

    During the process of watermelon seeds characteristic extraction as well as separation, watermelon seeds' major and minor axes, the length and width ratio have played a very important role in appearance regulating degree evaluation. It is quite difficult to find the answer of orthogonal bi-axes because the watermelon seeds are flat and irregular in shape and what's more there is no rule to follow. After a lot of experiments and research, the author proposed the algorithm of orthogonal bi-axes algorithm for granulated object. It has been put into practice and proved in the application of auto-separation system for watermelon seeds. This algorithm has the advantage of lower time complexity and higher precision compared with other algorithms. The algorithm can be used in the solution of other similar granulated objects, and has the widespread application value.

  8. Optimization of Lightweight Axles for an Innovative Carving Skateboard Based on Carbon Fiber Placement

    OpenAIRE

    Marc Fleischmann; Conrad Ehemann; Jörg Kaufmann; Holger Cebulla

    2018-01-01

    In 2003, the BMW Group developed a longboard called “StreetCarver”. The idea behind this product was to bring the perfect carving feeling of surf- and snowboarding on the streets by increasing the maneuverability of classical skateboard trucks. The outcome was a chassis based on complex kinematics. The negative side effect was the StreetCarver’s exceptional high weight of almost 8 kg. The main reason for this heaviness was the choice of traditional metallic engineering materials. In this rese...

  9. Characterization and development of closed form solutions for axle load spectra associated with trucks circulating the highways of Colombia

    Directory of Open Access Journals (Sweden)

    Luis Fernando Macea-Mercado

    2015-01-01

    Full Text Available El diseño adecuado de las estructuras de pavimento requiere de la estimación de los efectos producidos por las cargas de tráfi co. Por esta razón, es necesario predecir el número de vehículos que se desplazaran sobre superfi cies de carretera e identifi car las confi guraciones de ejes y la magnitud de la carga. Treinta y ocho (38 operativos de pesaje móviles fueron colocados en diferentes puntos estratégicos de la red vial nacional colombiana con el objetivo de caracterizar la condición de tráfi co del país; en estos operativos se evaluaron 59.622 camiones. Este artículo presenta espectros de carga por eje que podrían ser utilizados para caracterizar el estado del tráfi co de la red de carreteras de Colombia con el fi n de dimensionar las estructuras de pavimentos. Los datos mostraron que las diferentes confi guraciones de ejes (simple, doble y Tridem muestran dos picos, asociados a las condiciones de camiones cargados y descargados. Se observó que un número signifi cativo de ejes excede el límite de carga permitido, lo que podría explicar el estado crítico de la red de carreteras en Colombia. Por último, una mezcla de tres (3 distribuciones teóricas se utilizó para caracterizar las distribuciones generales de carga por eje. Se observó que los modelos propuestos presentan capacidades de predicción aceptables, por lo tanto, tienen potencial para ser utilizados como una herramienta confi able en el proceso de diseño de pavimentos.

  10. Simulation of pendulum shock experiments on a passenger car front axle; Simulation von Pendelschlagversuchen an einer PKW-Vorderachse

    Energy Technology Data Exchange (ETDEWEB)

    Sporer, L.; Witt, R.; Muehlbauer, R. [BMW Group, Muenchen (Germany)

    2001-07-01

    The contribution describes the development and application of a method for simulating loads resulting from misuse on car body components. The development of the method and its validation by experiments are described, and its application in the development of the BMW-5 series is gone into. [German] Der Beitrag beschreibt die Entwicklung und Anwendung einer Methode zur Simulation von Missbrauchsbelastungen an Fahrwerkskomponenten. Im ersten Abschnitt ist die systematische Entstehung der Methode und die Absicherung der Simulationsergebnisse durch Ersatzversuche dargestellt. In den folgenden Abschnitten steht die Anwendung der Methode in der Fahrwerksentwicklung bei BMW am Beispiel der Vorderachse der aktuellen 5-er Baureihe im Vordergrund. Das Deformationsverhalten einzelner Lenker bzw. die Schadenskette an der gesamten Achse werden sowohl fuer den seitlichen, als auch fuer den frontalen Pendelschlag aufgezeigt. (orig.)

  11. 49 CFR 393.71 - Coupling devices and towing methods, driveaway-towaway operations.

    Science.gov (United States)

    2010-10-01

    ... unless the relationship of such full-mounted vehicles to the rear axle or axles results in proper... towing vehicle that the relationship to the rear axle or axles results in proper distribution of the... Longitudinal strength in tension and compression 2 All tow-bars New tow-bars acquired and used by a motor...

  12. Analysis of the truck inventory and use survey from the truck size and weight perspective for trucks with four-axles or less : activity 1 : Task B identify market segments - competitive and noncompetitive TIUS data component

    Science.gov (United States)

    1996-10-01

    This report, as part of the U.S. Department of Transportation (DOT) Comprehensive Truck Size and Weight (TS&W) Study, provides factual information and analysis of the U.S. freight hauling truck fleet, and is based on the Truck Inventory and Use Surve...

  13. The petroleum and its products pipeline network as articulate axle of the social-environmental transformation; A malha dutoviaria de transporte de petroleo e derivados como eixo articulador de transformacao socio-ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira Filho, Aluisio Teles [TRANSPETRO - PETROBRAS Transportes, Rio de Janeiro, RJ (Brazil). Gerencia de Seguranca, Meio Ambiente e Saude; Dias, Janice; Vieira, Roberto Gomes [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2003-07-01

    The article describes the experience of the area of Social Responsibility in TRANSPETRO, a wholly Brazilian Subsidiary of PETROBRAS, which operates in the field of transport of petroleum, its by-products and gas, by way of oil and gas pipeline networks. Pipeline is the safety option for the transport of these products, but requires monitoring and the permanent management of the use and occupation of the soil and surrounding area. This care does not only depend on the Company as responsibility is much wider. Active participation by the communities affected by the operations is essential, principally in incorporating the rules of occupation and the use of the soil in the land surrounding the strips and the terminals. This participation is justified given that the action of third parties represents a significant proportion (70%) of the irregular situations registered by the Company. Community Relationship Management is one of the principal strategies to increase the safety of the pipelines integrated into the Company's programs of maintenance and operational control. Therefore, a plan of Community Relations has been implanted, focusing on the transformation of values to construct a community culture of co-habitation and co-responsibility for the pipeline land. (author)

  14. Sobrecompactación del suelo agricola parte I: influencia diferencial del peso y del número de pasadas Overcompaction of agricultural soil part I: differential influence of axle load and number of passes

    Directory of Open Access Journals (Sweden)

    Daniel Jorajuria

    2000-12-01

    Full Text Available Han sido objetivos principales de este trabajo, tanto el discriminar la responsabilidad de las variables independientes, peso y número de pasadas, en la distribución vertical de la compactación inducida, como obtener evidencia que permita decidir la conveniencia entre conjuntos ligeros que rueden muchas veces sobre la superficie trabajada, o conjuntos más grandes y pesados que resuelvan la tarea con menos pasajes. Se trabajó sobre un suelo de textura fina, con alta humedad presente. Las variables experimentales independientes configuraron dos tratamientos, tractor pesado y ligero, y tres diferentes número de pasadas, 1, 5 y 10, resultaron en seis subtratamientos de diferente intensidad de tráfico, más una parcela testigo sin tráfico. Los resultados no mostraron diferencias entre los tratamientos pesado y ligero, en el rango más superficial evaluado, sin embargo siempre fueron muy significativas las diferencias si se considera el rango de mayor profundidad. Disminuciones del rendimiento del pastizal del orden de 7 a 25% fueron medidas en las zonas adyacentes a las huellas, mientras que esas pérdidas ascendieron al rango de 52 a 76% dentro de la impronta dejada por las huellas del tráfico. Se pudo concluir que, el número de pasadas reiteradas sobre la misma senda, puede emular, e incluso reemplazar, al factor peso sobre el eje, en la responsabilidad principal de inducir compactaciones en el subsuelo. Diez pasadas, es el número crítico de rodadas, a partir del cual se pierden las ventajas de traficar con un tractor ligero, como alternativa a uno pesado con menos pasadas.The main objectives of this research were: to determine the responsability of weight, number of passes and independent variables, on the vertical distribution of subsoil compaction and to obtain evidence to decide upon the convenience of matching equipments with light or heavy tractors, according to their differences in passes on the field. Field tests were carried out on grassland, on a typic Argiudol with a soil moisture below, but near to field capacity. The dependent experimental variable was the induced soil compaction and was related to bulk density (assessed with gamma probe, penetration resistance (measured with an electronic cone penetrometer, and remaining grassland yield, six and eight months after traffic treatments were applied. Data from two tests, with two phases of data logging were analysed, totalizing a three year period of assessment pursuit. Results did not show differences between heavy and light treatments in the shallower depth range. Nevertheless, highly significant differences were shown if the deepest range is considered. Decrease in grassland yields ranging from 7 to 25% were measured in out-of-track areas, and 52 to 76% in intrack areas. It was concluded that the number of repeated passes on the same tramlines of a light tractor, can do as much or even greater damage than the heavier tractor with fewer passes. Ten is the critical number of passes, beyond it, advantages taken from the use of a light tractor are lost.

  15. Method and instrumentation for detection of rail defects, in particular rail top defects

    NARCIS (Netherlands)

    Li, Z.; Molodova, M.

    2011-01-01

    A method and instrumentation for detection of rail defects, in particular rail top defects, in a railway-track by measuring an axle box acceleration signal of a rail vehicle, wherein a longitudinal axle box acceleration signal is used as a measure to detect the occurrence of said rail defects, in

  16. 49 CFR 571.7 - Applicability.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE SAFETY STANDARDS General § 571.7 Applicability. (a... B of this part applies according to its terms to all motor vehicles or items of motor vehicle... requirements of this chapter, and the Act, unless, at a minimum, the trailer running gear assembly (axle(s...

  17. Updating the school bus standard vehicle for load rating Alabama bridges.

    Science.gov (United States)

    2010-06-01

    The objective of this project is to identify a representative school bus (weight and axle spacing) for load rating highway bridges. The ALDOT Bridge Rating and Load Test Section currently uses a 12.5-ton school bus (four tons on the front axle and 8....

  18. Investigation of causes of failures of flexible pavements: a case ...

    African Journals Online (AJOL)

    The visual inspection of the pavement showed that due to the hardening of the bitumen and overloading, cracks and potholes were very common for the whole stretch of the road. Axle load data revealed that, there has been a tendency to exceed the maximum allowed axle load limits, especially until 19th august, 1999, after ...

  19. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

    NARCIS (Netherlands)

    Loges, Sonja; Schmidt, Thomas; Tjwa, Marc; van Geyte, Katie; Lievens, Dirk; Lutgens, Esther; Vanhoutte, Davy; Borgel, Delphine; Plaisance, Stephane; Hoylaerts, Marc; Luttun, Aernout; Dewerchin, Mieke; Jonckx, Bart; Carmeliet, Peter

    2010-01-01

    The transforming and tumor growth-promoting properties of Axl, a member of the Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases (TAMRs), are well recognized. In contrast, little is known about the role of the TAMR ligand growth arrest-specific gene 6 (Gas6) in tumor biology. By using

  20. Large stone asphalt mix design for heavy duty asphalt pavements

    CSIR Research Space (South Africa)

    Rust, FC

    1990-08-01

    Full Text Available The recent increase in traffic volumes and also axle loads on some of the major routes in South Africa has extended the traffic classes beyond the current highest design class. Additionally there is a strong lobby to increase the legal axle load...

  1. 77 FR 3505 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance...

    Science.gov (United States)

    2012-01-24

    ... Sunshine 368 Inc. (Workers) Corona, NY 01/04/12 12/25/11 81213 American Express (Workers). Salt Lake City.../12 (Company). 81207 American Axle & Detroit, MI 01/03/12 01/02/12 Manufacturing (Company). 81208 American Axle & Cheektowaga, NY....... 01/03/12 12/30/11 Manufacturing, Inc. (AAM) (Company). 81209 TriNet...

  2. A Piston-Rotaxane with Two Potential Stripes: Force Transitions and Yield Stresses

    Directory of Open Access Journals (Sweden)

    Edith M. Sevick

    2013-10-01

    Full Text Available We examine a rod piston-rotaxane system, where the positions of several mobile rings on the axle are controlled by an external force acting on one of the rings. This allows us to access the translational entropy of the rings. For a simple rotaxane molecule with an axle that has uniform ring-axle interactions along its length, the molecule behaves like a miniature piston filled with a one-dimensional ideal gas. We then examine the effect of two stripes on the axle, having different ring-axle interactions with the mobile rings, so that one section is of high energy (repulsive for the rings and another section is of lower energy (or attractive. This kind of rotaxane can exhibit rapid changes in displacement or force, and in particular, this molecule can exhibit a yield stress in which the piston suddenly compresses under a small increase in the applied force.

  3. Análise de falha por fadiga em eixo de transmissão utilizando o método dos elementos finitos

    Directory of Open Access Journals (Sweden)

    Fernando de Azevedo Silva

    2016-01-01

    Full Text Available This study aims to present the application of the finite element method to perform stress and fatigue analysis on a mechanical drive axle. Drive axles are widely used in rotating machinery and are subject to fatigue problems. The rotary transmission axle in this study is supported in bearings loaded by an alternating force of 6.8 kN, wherein the axle has rounding radii all 0.003 m in size and a ground surface of AISI 1050 steel with Young’s elasticity modulus of 206.8 GPa and Poisson modulus of 0.28. We present the rupture conditions ensuing from tension as well as fatigue, for a lifetime of the transmission axle of 350,000 cycles. The quantitative results compared satisfactorily to the empirical fatigue data.

  4. Mount for continuously orienting a collector dish in a system adapted to perform both diurnal and seasonal solar tracking

    Science.gov (United States)

    Brantley, L. W., Jr.; Lawson, B. D. (Inventor)

    1977-01-01

    A collector dish is continuously oriented toward the sun in a system adapted to perform both diurnal and seasonal solar tracking. The mount is characterized by a rigid, angulated axle having a linear midportion supporting a collector dish, and oppositely extended end portions normally related to the midportion of the axle and received in spaced journals. The longitudinal axis of symmetry for the midportion of the axle is coincident with a seasonal axis while the axes of the journals are coincident with a diurnal axis paralleling the earth's polar axis. Drive means are provided for periodically displacing the axle about the diurnal axis at a substantially constant rate, while other drive means are provided for periodically indexing the dish through 1 deg about the seasonal axis whereby the position of the dish relative to the axle is varied for accommodating seasonal tracking as changes in the angle of inclination of the polar axis occurs.

  5. Tie-ballast interaction.

    Science.gov (United States)

    2015-09-28

    Improvements in railroad efficiency in the future may likely require higher passenger train speeds and heavier freight axle loads. As the demand for more efficient rail transportation grows, so does the need for higher performance and lower maintenan...

  6. In-line drivetrain and four wheel drive work machine using same

    Science.gov (United States)

    Hoff, Brian

    2008-08-05

    A four wheel drive articulated mine loader is powered by a fuel cell and propelled by a single electric motor. The drivetrain has the first axle, second axle, and motor arranged in series on the work machine chassis. Torque is carried from the electric motor to the back differential via a pinion meshed with the ring gear of the back differential. A second pinion oriented in an opposite direction away from the ring gear is coupled to a drive shaft to transfer torque from the ring gear to the differential of the front axle. Thus, the ring gear of the back differential acts both to receive torque from the motor and to transfer torque to the forward axle. The in-line drive configuration includes a single electric motor and a single reduction gear to power the four wheel drive mine loader.

  7. Equivalent damage of loads on pavements

    CSIR Research Space (South Africa)

    Prozzi, JA

    2009-05-26

    Full Text Available This report describes a new methodology for the determination of Equivalent Damage Factors (EDFs) of vehicles with multiple axle and wheel configurations on pavements. The basic premise of this new procedure is that "equivalent pavement response...

  8. Educational Materials Development in Primary Science: Simple Machines

    Science.gov (United States)

    Franks, Frank L.; Butterfield, Lawrence H., Jr.

    1977-01-01

    Evaluated was the ability of 27 legally blind elementary students to identify and manipulate the parts of the following adapted simple machines: lever, inclined plane, wheel and axle, and pulley. (SBH)

  9. Long-term pavement performance pavement loading user guide (LTPP PLUG).

    Science.gov (United States)

    2013-10-01

    "This guide addresses the selection and use of axle loading defaults for Mechanistic-Empirical Pavement Design : Guide (MEPDG) applications. The defaults were developed based on weigh-in-motion (WIM) data from the Long- : Term Pavement Performance (L...

  10. Improvement of the directional stability of passenger car trailer couplings with actively controlled steering

    Science.gov (United States)

    Desens, Jens

    The stabilization of pendulum oscillations of passenger car trailer couplings, using active steering, was examined. A linear model of the couplings was presented. Each axle was provided with a controller. The controllers were optimized, with regard to necessary sensors, in order to minimize costs. The rear and the front axles were provided with a control unit in order to compute the potential prevailing in the active steering of several axles. It was shown that the passenger car rear axle was the most suitable for coupling stabilization. The experiment was simulated, using a complex coupling model. The developed controller allowed the passenger car trailer to be driven at a speed higher than 150 km per hour.

  11. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  12. 14 CFR 27.725 - Limit drop test.

    Science.gov (United States)

    2010-01-01

    ... under impact of the tire (at the proper inflation pressure) plus the vertical component of the axle..., during impact, on the mass used in the drop test (i.e., the acceleration dv/dt in g's recorded in the...

  13. Learning the Lessons of Leadership Experience: Tools for Interactive Case Method Analysis

    National Research Council Canada - National Science Library

    Hill, Randall W., Jr; Gordon, Andrew S; Kim, Julia M

    2004-01-01

    The Army Excellence in Leadership (AXL) project at the University of Southern California's Institute for Creative Technologies is aimed at supporting the acquisition of tacit knowledge of military leadership through the development...

  14. 49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.

    Science.gov (United States)

    2010-10-01

    ... expressed in terms of maximum equipment weights, and either minimum equipment lengths or axle spacing. (c) The instructions regarding dimensions shall be expressed in terms of feet and inches of cross section...

  15. Apparatus and Method for Generating Electric Energy in a Fluid Environment

    National Research Council Canada - National Science Library

    Steinbrecher, Donald H

    2005-01-01

    ... and rotatable about a pivot axis by movement of the attached connector rod, a housing supporting the wing member, a gear system disposed in the housing, an axle interconnecting each of the crank members...

  16. Dynamometer

    Data.gov (United States)

    Federal Laboratory Consortium — TTCI's unique single-ended inertia dynamometer is used to conduct research and tests on railroad wheels, axles, and brake shoes. The dynamometer has the capability...

  17. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy : final report.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  18. An MPC Algorithm with Combined Speed and Steering Control for Obstacle Avoidance in Autonomous Ground Vehicles

    Science.gov (United States)

    2015-04-24

    generated at the front axle and the rear axle, respectively. They are predicted using the the pure-slip Pacejka Magic Formula tire model [20], and are...simulations with a 14 DoF vehicle model [22] that includes suspension dynamics [22], nonlinear tire dynamics [20], powertrain dynamics [23] [24], and brake...of the international class VI truck”, SAE Technical Paper, No. 2000-01-0288, 2000. [24] T. Ersal, M. Brudnak, A. Salvi, J. L. Stein, Z. Filipi, and H

  19. Substitution effect and effect of axle’s flexibility at (pseudo-rotaxanes

    Directory of Open Access Journals (Sweden)

    Friedrich Malberg

    2014-06-01

    Full Text Available This study investigates the effect of substitution with different functional groups and of molecular flexibility by changing within the axle from a single C–C bond to a double C=C bond. Therefore, we present static quantum chemical calculations at the dispersion-corrected density functional level (DFT-D3 for several Leigh-type rotaxanes. The calculated crystal structure is in close agreement with the experimental X-ray data. Compared to a stiffer axle, a more flexible one results in a stronger binding by 1–3 kcal/mol. Alterations of the binding energy in the range of 5 kcal/mol could be achieved by substitution with different functional groups. The hydrogen bond geometry between the isophtalic unit and the carbonyl oxygen atoms of the axle exhibited distances in the range of 2.1 to 2.4 Å for six contact points, which shows that not solely but to a large amount the circumstances in the investigated rotaxanes are governed by hydrogen bonding. Moreover, the complex with the more flexible axle is usually more unsymmetrical than the one with the stiff axle. The opposite is observed for the experimentally investigated axle with the four phenyl stoppers. Furthermore, we considered an implicit continuum solvation model and found that the complex binding is weakened by approximately 10 kcal/mol, and hydrogen bonds are slightly shortened (by up to 0.2 Å.

  20. A MECHANISTIC-EMPIRICAL IMPACT ANALYSIS OF DIFFERENT TRUCK CONFIGURATIONS ON A JOINTED PLAIN CONCRETE PAVEMENT (JPCP

    Directory of Open Access Journals (Sweden)

    Lubinda F. Walubita

    2017-12-01

    Full Text Available Until the last decade, the 1993 American Association of State Highway and Transportation Officials (AASHTO design guide has been traditionally used for the design of flexible and rigid pavements in the USA and some parts of the world. However, because of its inability to meet the new traffic and material challenges, a Mechanistic Empirical Pavement Design Guide (MEPDG was introduced based on an NCHRP 1-37 A study conducted in 2004. This study used the MEPDG software and associated models to determine, through comparative truck damage analysis, the effects of nine different truck configurations on a 12 inch-jointed plain concrete pavement (JPCP. The study recorded truck damages at the end of each analysis period (40 years and comparatively analyzed the relative pavement damage in terms of fatigue cracking, faulting, and surface roughness. The results indicated that the most critical damage to the concrete pavement was caused by truck cases with high and uneven load distribution and relatively smaller size axles group (e.g. tandem. Other key findings included the following; (1 increase in damage when the truckloads were shifted between the same size axles, (2 decrease in truck damage when the truckloads were shifted from tandem axle to quad axles, and (3 no change in truck damage when the axle spacing was increased between wheels of a quad axle.

  1. Tolerance Limit for Trucks with Excess Load in Transport Regulation in Indonesia

    Directory of Open Access Journals (Sweden)

    Sigit Hadiwardoyo

    2012-05-01

    Full Text Available Reliability of a road is mandatory since damaged will impede the traffic. Destruction is caused by various factors; one of the most important factors is excess load. Overload may give the load of each axle of a vehicle exceeds the determined standard. This condition occurs in trucks exceeding the load limit. In designing the structure of a road based on the method of Directorate General of Highways Ministry of Public Works of the Republic of Indonesia, axle load calculated in equivalent-number, or known as equivalent axle load (EAL, of 8.16 tons of standard axle. Total equivalent-number over the service life is defined as cumulative equivalent standard axle load (CESA. Due to traffic volume exceeding the volume forecast or, in other words there is an excessive load of traffic, it will make CESA achieved faster than planned. This excessive load in Indonesia, however, has been  considered as a factor of environmental condition, so there is a need to introduce a correction factor for EAL as high as 20-25% in the process of designing flexible and rigid pavement so as to reduce early damage.

  2. Effects of Variation in Truck Factor on Pavement Performance in Pakistan

    Directory of Open Access Journals (Sweden)

    Rabia Chaudry

    2013-01-01

    Full Text Available Seasonal variation coupled with heavy axle loading is the key factor in rapid road deterioration in Pakistan. The serviceability loss is further accelerated by the fact that truck drivers and owners consider overloading as a profitable practice unaware of the adverse effects of this practice. Weigh-in-motion data from two stations located between two major cities of Pakistan (Peshawar and Rawalpindi on Grand Trunk Road (N-5 were collected and analyzed. Analysis of variance and comparison of actual and designed truck factor were performed to identify the most damaging axle truck type. It was found that axle truck type 3 (single/tandem axle is most damaging among all truck types. The actual truck factor for axle truck type 3 is 6.4 times greater than design truck factor. Regression expressions of different forms were also investigated to determine the relationship between truck factor and gross vehicular weight for the specified truck types. An optimum generalization strategy was used to prevent over-generalization and ensure accuracy. For data analysis, 75% of data was used to develop regression models and remaining 25% was to validate those models. The results show that the polynomial expressions performed best and provide a robust relationship that can be employed by the highway authorities to estimate truck factor from gross vehicular weight with a high degree of confidence. It was also observed that damaging effect of various types of trucks was very severe and quite high.

  3. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle.

    Science.gov (United States)

    Peng, Jiankun; He, Hongwen; Liu, Wei; Guo, Hongqiang

    2015-01-01

    This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved.

  4. Dual Roadside Seismic Sensor for Moving Road Vehicle Detection and Characterization

    Science.gov (United States)

    Wang, Hua; Quan, Wei; Wang, Yinhai; Miller, Gregory R.

    2014-01-01

    This paper presents a method for using a dual roadside seismic sensor to detect moving vehicles on roadway by installing them on a road shoulder. Seismic signals are split into fixed time intervals in recording. In each interval, the time delay of arrival (TDOA) is estimated using a generalized cross-correlation approach with phase transform (GCC-PHAT). Various kinds of vehicle characterization information, including vehicle speed, axle spacing, detection of both vehicle axles and moving direction, can also be extracted from the collected seismic signals as demonstrated in this paper. The error of both vehicle speed and axle spacing detected by this approach has been shown to be less than 20% through the field tests conducted on an urban street in Seattle. Compared to most existing sensors, this new design of dual seismic sensor is cost effective, easy to install, and effective in gathering information for various traffic management applications. PMID:24526304

  5. Refuelling machine for nuclear reactor

    International Nuclear Information System (INIS)

    Shumyakin, E.P.; Sabir-de-Ribas, K.I.; Druzhinsky, I.A.; Shishov, G.P.; Andreichikov, B.I.

    1979-01-01

    The proposed manipulating means consists of housing, wherein a gripping means is arranged to grip a fuel assembly being transferred. The gripping means is coupled to a drive having a chain which is in contact with a sprocket mounted on an axle arranged in the sealed housing. The driving force of the drive is transmitted to the gripping means. The driving force is controlled by a force regulator mounted on the gripping means. The force regulator comprises two force tranducers mounted on the sealed housing, and a spring suspension member installed in the gripping means. Some clearance is allowed where the drive sprocket axle is secured in the walls of the sealed housing. The ends of the axle extend outside the sealed housing and are coupled to sensitive elements of the force transducers

  6. Fatigue and rutting lives in flexible pavement

    Directory of Open Access Journals (Sweden)

    Ahmed Ebrahim Abu El-Maaty Behiry

    2012-12-01

    Full Text Available Flexible pavement is designed based on axle load limits and climatic conditions. The Egyptian code has specified certain load limits that should not be exceeded. The overweight trucks cause severe deterioration to the pavement and thus reduce its life. The study aims at studying the effect of axle load increase, and the variation in pavement modulus, on the overall pavement life. The research uses the BISAR software and the Egyptian environmental and pavement materials conditions to estimate the tensile strains occurring under the asphalt concrete (AC layer and the compressive strains above the subgrade surface. The results revealed that tensile and compressive strain increased with increasing axle loads and decreased with increasing asphalt layer modulus thus the violating trucks should be unloaded when their weights exceed certain limits. Base thickness and subgrade resilient modulus were the key elements which control the equilibrium between fatigue and rutting lives.

  7. Wheel-rail profile matching based on finite element method for Beijing metro

    Science.gov (United States)

    Liu, Jia-huan; Zhang, Jun; Liu, Xiao-dong; Zhu, Huang-shi; Zhang, Lin; Shang, Weipeng

    2017-09-01

    An instrument that measures wheel-rail appearance is used to measure the size of the wheel and rail in the section of the Baishiqiao South Station of Beijing Metro Line 6 to develop a finite element entity. Different working conditions such as axle load and traction are considered. The results show that: Under axle load, the matching performance of wheel I/rail II is improved, its contact area is the largest, and its equivalent stress and contact force are minimal; Under traction force, the matching performance of wheel I/rail II is improved, and the shear stress and equivalent stress are minimal, and thus is ideal.

  8. Isotopic study of the wear of sliding bearings with plastic friction surface

    International Nuclear Information System (INIS)

    Pandur, J.; Varkonyi, A.

    1978-01-01

    A new complex device has been elaborated for the investigation of the duration of bearings in the Institute of Isotopes of the Hungarian Academy of Sciences. The simultaneous determination of wear by an isotopic method the coefficient of friction by means of a Wheatstone bridge and the bearing temperature by means of a thermoresistor is described. Dynamic loading and variable revolution per minute are applied to produce a forced wear of the bearings. The isotopically labelled wear products are removed by oil and the collected sample is measured by a scintillation detector. Wear of a steel axle in plastic housing and plastic coated axle in cast iron housing was determined. (V.N.)

  9. THE CYTOGENETIC EFFECTS WITH LEAD NITROGENOUS TREATMENT AT HELIANTHUS ANNUUS L. FAVORIT AND PR64A83 CULTIVARS

    Directory of Open Access Journals (Sweden)

    Felicia Vlad-Rusen

    2007-08-01

    Full Text Available The analysis of some cytogenetic parameters shows that the nitrogenous lead application on Favorit and PR64A83 cultivars of sunflower exercises a light mutagenic effect on the cells of the root apex. At same time an intensification of the frequency of the ana-telophases with aberration takes place, especially of those with bridges, with lagging chromosomes, but also of those with fragments, demonstrating the perturbatory action that this substance exercises on the division axle. The apparition of a great number of metaphases with displayed chromosomes proves the perturbation of well function to division axle, effect signalized especially at the Favorit cultivar.

  10. Portable, battery-driven nuclear radiation measuring instrument with a portable reversible scale cylinder enclosing a light source

    International Nuclear Information System (INIS)

    Jordan, K.; Kuehnert, H.; Hofmann, J.

    1970-01-01

    The transparent scale drum of the measuring unit is lighted from the inside. For this purpose, an incandescent lamp is held in a shockproof socket. It is installed on the tip of an axle end which penetrates into the interior of the drum. This is attached to one front of the drum in such a way that it can be withdrawn from the drum together with the lamp after loosening of one screw holding the foot. The connecting wires of the lamp are run out of the drum through a bore in the axle end and are connected to soldering lugs. (DG/RF) [de

  11. Data Quality and Reliability Analysis of U.S. Marine Corps Ground Vehicle Maintenance Records

    Science.gov (United States)

    2015-06-01

    SYSTEM 8 DIST DISTRIBUTION  SYSTEMS E10 AXLE N 1 E AXLE AXLE  SYSTEM 10 GUN GUN  TUBE, BREECH, AND...SUSPENSION  SYSTEM 17 PUMP PUMPS AND COMPONENTS F18 SUSP N 18 F SUSP SUSPENSION  SYSTEM 18 RECL RECOIL  MECHANISM F19 SUSP N 1 F SUSP SUSPENSION  SYSTEM 19 REG...474 J COOL COOLING  SYSTEM 17 PUMP PUMPS AND COMPONENTS J18 COOL N 2 J COOL COOLING  SYSTEM 18 RECL RECOIL  MECHANISM J19 COOL N 29 J COOL COOLING  SYSTEM

  12. Analysis of Rail Vehicle Suspension Spring with Special Emphasis on Curving, Tracking and Tractive Efforts

    Science.gov (United States)

    Kumbhalkar, M. A.; Bhope, D. V.; Vanalkar, A. V.

    2016-09-01

    The dynamics of the rail vehicle represents a balance between the forces acting between wheel and rail, the inertia forces and the forces exerted by suspension and articulation. Axial loading on helical spring causes vertical deflection at straight track but failures calls to investigate for lateral and longitudinal loading at horizontal and vertical curves respectively. Goods carrying vehicle has the frequent failures of middle axle inner suspension spring calls for investigation. The springs are analyzed for effect of stress concentration due to centripetal force and due to tractive and breaking effort. This paper also discusses shear failure analysis of spring at curvature and at uphill at various speeds for different loading condition analytically and by finite element analysis. Two mass rail vehicle suspension systems have been analyzed for vibration responses analytically using mathematical tool Matlab Simulink and the same will be evaluated using FFT vibration analyzer to find peak resonance in vertical, lateral and longitudinal direction. The results prove that the suspension acquires high repeated load in vertical and lateral direction due to tracking and curving causes maximum stress concentration on middle axle suspension spring as height of this spring is larger than end axle spring in primary suspension system and responsible for failure of middle axle suspension spring due to high stress acquisition.

  13. Can a String's Tension Exert a Torque on a Pulley?

    Science.gov (United States)

    Krause, Dennis E.; Sun, Yifei

    2011-01-01

    A typical textbook problem in rotational dynamics involves calculating the angular acceleration of a massive pulley due to a string, such as in the example shown in Fig. 1. The string is assumed to be massless and to move without slipping over the pulley, which is mounted on a frictionless axle. If T[subscript L] and T[subscript R] are the…

  14. 49 CFR 229.45 - General condition.

    Science.gov (United States)

    2010-10-01

    ... components, including third rail shoes or beams, traction motors and motor gear cases, and fuel tanks; fuel... other structural infirmities of components, including quill drives, axles, gears, pinions, pantograph shoes and horns, third rail beams, traction motor gear cases, and fuel tanks. Brake System ...

  15. Handling Stability of Tractor Semitrailer Based on Handling Diagram

    Directory of Open Access Journals (Sweden)

    Ren Yuan-yuan

    2012-01-01

    Full Text Available Handling instability is a serious threat to driving safety. In order to analyze the handling stability of a tractor semitrailer, a handling diagram can be used. In our research, considering the impact of multiple nonsteering rear axles and nonlinear characteristics of tires on vehicle handling stability, the handling equations are developed for description of stability of tractor semi-trailer. Then we obtain handling diagrams so as to study the influence of driving speed, loaded mass, and fifth wheel lead on vehicle handling stability. The analysis results show that the handling stability of a tractor semi-trailer when the tractor has two nonsteering rear axles is better than that when the tractor has only one nonsteering rear axle. While the stability in the former case is slightly influenced by driving speed and loaded mass, the latter is strongly influenced by both. The fifth wheel lead is found to only slightly influence handling stability for both tractor semi-trailers. Therefore, to ensure the driving safety of tractor semi-trailers when the tractor has only one nonsteering rear axle, much stricter restraints should be imposed on driving speed, and the loaded mass must not exceed the rated load of the trailer.

  16. 76 FR 4264 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702...

    Science.gov (United States)

    2011-01-25

    ... coating and consequent stress corrosion. In both cases, the MLG did not collapse. * * * * * The unsafe... Bombardier, Inc., 400 C[ocirc]te-Vertu Road West, Dorval, Qu[eacute]bec H4S 1Y9, Canada; telephone 514-855... axle thrust face, damage to the protective coating and consequent stress corrosion. In both cases, the...

  17. A Pro-Forma approach to Car-Carrier Design

    CSIR Research Space (South Africa)

    Benade, R

    2016-11-01

    Full Text Available In this work a pro-forma approach is developed for assessing truck and centre-axle tag-trailer or 50/50 car-carrier designs in terms of their compliance with the South African Performance-Based Standards (PBS) pilot project requirements. First...

  18. 77 FR 46677 - Vehicle Certification; Contents of Certification Labels

    Science.gov (United States)

    2012-08-06

    ... each axle, the vehicle type classification (e.g., passenger car, multipurpose passenger vehicle, truck... passenger car certification label must contain the statement: ``This vehicle conforms to all applicable..., respectively, to passenger cars, multipurpose passenger vehicles (MPVs) and trucks with a GVWR of 6,000 pounds...

  19. Vehicle state estimator based regenerative braking implementation on an electric vehicle to improve lateral vehicle stability

    NARCIS (Netherlands)

    Jansen, S.T.H.; Boekel, J.J.P. van; Iersel, S.S. van; Besselink, I.J.M.; Nijmeijer, H.

    2013-01-01

    The driving range of electric vehicles can be extended using regenerative braking. Regenerative braking uses the elctric drive system, and therefore only the driven wheels, for decelerating the vehicle. Braking on one axle affects the stability of the vehicle, especially for road conditions with

  20. Complex eigenvalue analysis of railway wheel/rail squeal | Goo ...

    African Journals Online (AJOL)

    The effect of parameters such as friction coefficient, wheel/rail contact position, axle load, etc. on the instable vibration was examined. The instability of the vibration system was sensitive to the stiffness of rail support. In lateral creepage when the adhesion coefficient was less than 0.1, instable vibration modes did not occur.

  1. 78 FR 79391 - Foreign-Trade Zone (FTZ) 22-Chicago, Illinois, Notification of Proposed Production Activity...

    Science.gov (United States)

    2013-12-30

    ... filters; paper filters; filter assemblies; frame and filter assemblies; HEPA filters; maintenance packs... pans; retaining rings; bushing axles; pizza pans; water filters; filter and frame assemblies; HEPA...; cable clamps; locks; belts; O-rings; sealing gaskets; support packages; filter bags; disposable bags...

  2. A reversible, unidirectional molecular rotary motor driven by chemical energy

    NARCIS (Netherlands)

    Fletcher, SP; Dumur, F; Pollard, MM; Feringa, BL

    2005-01-01

    With the long-term goal of producing nanometer-scale machines, we describe here the unidirectional rotary motion of a synthetic molecular structure fueled by chemical conversions. The basis of the rotation is the movement,of a phenyl rotor relative to a naphthyl stator about a single bond axle. The

  3. 49 CFR Appendix D to Part 230 - Civil Penalty Schedule

    Science.gov (United States)

    2010-10-01

    ... and alterations: (a) Failure to obtain approval before making riveted alterations on unstayed portions...; failure to properly note removal 1,500 3,000 230.60 Time of washing: (a) Failure to thoroughly wash boiler...: (a) Condemning defects 1,000 2,000 (b) Journal diameter: Failure to stamp on end of axle 750 1,000...

  4. Verge and Foliot Clock Escapement: A Simple Dynamical System

    Science.gov (United States)

    Denny, Mark

    2010-01-01

    The earliest mechanical clocks appeared in Europe in the 13th century. From about 1250 CE to 1670 CE, these simple clocks consisted of a weight suspended from a rope or chain that was wrapped around a horizontal axle. To tell time, the weight must fall with a slow uniform speed, but, under the action of gravity alone, such a suspended weight would…

  5. AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XXI, I--MAINTAINING THE AIR SYSTEM--CATERPILLAR DIESEL ENGINE, II--UNDERSTANDING REAR END SUSPENSION.

    Science.gov (United States)

    Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

    THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF THE DIESEL ENGINE AIR SYSTEM AND REAR AXLE SUSPENSION USED ON DIESEL POWERED VEHICLES. TOPICS ARE (1) AIR INDUCTION AND EXHAUST SYSTEM, (2) VALVE MECHANISM, (3) TROUBLESHOOTING THE AIR SYSTEM, (4) PURPOSE OF VEHICLE SUSPENSION, (5) TANDEM…

  6. 78 FR 49290 - Oshkosh Defense, a Division of Oshkosh Corporation, Including On-Site Leased Workers From...

    Science.gov (United States)

    2013-08-13

    ... foreign country. During the reconsideration investigation, the subject firm addressed a newspaper article... AARF axles), including component parts. The workers are not separately identifiable by article produced... in production of, and administrative functions in support of, the articles produced by the subject...

  7. 49 CFR Appendix G to Subchapter B... - Minimum Periodic Inspection Standards

    Science.gov (United States)

    2010-10-01

    ...) Loose brake components including air chambers, spiders, and cam shaft support brackets. (4) Audible air... pitman arm on the steering gear output shaft. f. Power Steering. Auxiliary power assist cylinder loose. g... line will cause the axle to return to alignment). b. Spring Assembly. (1) Any leaves in a leaf spring...

  8. Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma

    DEFF Research Database (Denmark)

    Choueiri, Toni K; Escudier, Bernard; Powles, Thomas

    2015-01-01

    BACKGROUND: Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) as well as MET and AXL, each of which has been implicated in the pathobiology of metastatic renal-cell carcinoma or in the development of resistance to an...

  9. Impact of increasing freight loads on rail substructure from fracking sand transportation.

    Science.gov (United States)

    2014-03-01

    In this report the effect of surface infiltration of frac sand and heavy axle loads (HALs) were studied for their impact on the ballast layer. : Different combinations of ballast and fracking sand were constructed to observe long term trends of defor...

  10. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial

    DEFF Research Database (Denmark)

    Choueiri, Toni K; Escudier, Bernard; Powles, Thomas

    2016-01-01

    BACKGROUND: Cabozantinib is an oral inhibitor of tyrosine kinases including MET, VEGFR, and AXL. The randomised phase 3 METEOR trial compared the efficacy and safety of cabozantinib versus the mTOR inhibitor everolimus in patients with advanced renal cell carcinoma who progressed after previous...

  11. Simple Machines Made Simple.

    Science.gov (United States)

    St. Andre, Ralph E.

    Simple machines have become a lost point of study in elementary schools as teachers continue to have more material to cover. This manual provides hands-on, cooperative learning activities for grades three through eight concerning the six simple machines: wheel and axle, inclined plane, screw, pulley, wedge, and lever. Most activities can be…

  12. Fun with Physics in the Elementary School.

    Science.gov (United States)

    Ediger, Marlow

    Primary grade pupils can become fascinated with simple machines. This paper suggests that teachers have simple machines in the classroom for a unit of study. It proposes some guidelines to create a unit of study for six simple machines that include the fulcrum, inclined plane, pulley, wheel and axle, wedge, and screw. Friction, gravity, force, and…

  13. The Fluid Foil: The Seventh Simple Machine

    Science.gov (United States)

    Mitts, Charles R.

    2012-01-01

    A simple machine does one of two things: create a mechanical advantage (lever) or change the direction of an applied force (pulley). Fluid foils are unique among simple machines because they not only change the direction of an applied force (wheel and axle); they convert fluid energy into mechanical energy (wind and Kaplan turbines) or vice versa,…

  14. Simple Machine Junk Cars

    Science.gov (United States)

    Herald, Christine

    2010-01-01

    During the month of May, the author's eighth-grade physical science students study the six simple machines through hands-on activities, reading assignments, videos, and notes. At the end of the month, they can easily identify the six types of simple machine: inclined plane, wheel and axle, pulley, screw, wedge, and lever. To conclude this unit,…

  15. 36 CFR 7.71 - Delaware Water Gap National Recreation Area.

    Science.gov (United States)

    2010-07-01

    ... 3 miles long and follows the west bank of the Delaware River and closely parallels the east side of... wheels on a vehicle, regardless of load or weight, as follows: (i) Two-axle car, van or truck $3 (ii) Two...

  16. 29 CFR 1910.180 - Crawler locomotive and truck cranes.

    Science.gov (United States)

    2010-07-01

    ..., operating machinery and boom, mounted on a base or platform equipped with axles and rubber-tired wheels for...-attaching equipment such as load blocks, shackles, and slings. (27) Load block (upper) means the assembly of hook or shackle, swivel, sheaves, pins, and frame suspended from the boom point. (28) Load block (lower...

  17. The influence of the undercarriage and tire inflation rating on drawbar characteristics of tractors

    Directory of Open Access Journals (Sweden)

    Petr Vykydal

    2012-01-01

    Full Text Available The aim of the measurement was to verify the drawbar characteristics of chosen tractors with different undercarriages. The tractors were of the same engine power as well as type of gearbox (PowerShift – gears full shifted while loaded. We were dealing with the wheeled tractor John Deere 8320 and crawler tractor John Deere 8320RT. The measurement was implemented in the land register of Vrbovec (Znojmo region in an area where green peas were grown as the main product and winter wheat as the preceding crop. The measured and the counterproductive tractors were interconnected by the rope containing strain-gauge force sensors. The wheeled tractor was decelerated by the tractor crawler. The tractor crawler was decelerated by two wheeled tractors. The wheeled tractor’s stress-strain properties were also measured applying two pressure rating alternatives. Variant A presented inflation pressure of 160 kPa on the front axle and of 140 kPa on the rear axle. Variant B applied inflation pressure of 120 kPa on the front axle and of 100 kPa on the rear axle. Measured and calculated findings reveal that the tractor crawler achieved higher drawbar power and lower specific tractive consumption and traction slip than the wheeled tractor with both variants of inflation. Comparing the stress-strain characteristics of the wheeled tractor with a different tire inflation illustrates that using variant B, higher drawbar power and lower specific tractive consumption and traction slip were measured.

  18. Wind data from Kennedy Airport

    Science.gov (United States)

    1997-06-01

    A 700-foot array of horizontal and vertical single-axle anemometers was installed at New York's Kennedy Airport on 30-foot poles under the approach to Runway 31R. One-minute average measurements were recorded continuously, with a few breaks, from Sep...

  19. Rear-heavy car control by adaptive linear optimal preview

    Science.gov (United States)

    Thommyppillai, M.; Evangelou, S.; Sharp, R. S.

    2010-05-01

    Adaptive linear optimal preview control theory is applied to a simple but non-linear car model, with parameters chosen to make the rear axle saturate first in any quasi-steady manoeuvre. The tendency of such a car to spin above a critical speed, which is a function of its running state, causes control to be especially difficult when operating near to the limit of the rear-axle force system. As in previous work, trim states and optimal gains are computed off-line for a given speed and a full range of lateral accelerations. Gain-scheduling with interpolation over trims and gain sets is used to keep the control appropriate to the running conditions, as they change. Simulations of manoeuvres are used to test and demonstrate the system capability. It is shown that utilising the rear-axle lateral-slip ratio as the scheduling variable, in the case of this rear-heavy car, gives excellent tracking, even when the tyres are run close to full saturation. It is implied by this and previous work that the general case can be treated effectively by monitoring both front- and rear-axle slips and scheduling on a worst-case basis.

  20. Case study guidelines.

    Science.gov (United States)

    2017-03-01

    In TxDOT project 0-6817, Review and Evaluation of Current Gross Vehicle Weights and Axle : Load Limits, the project team reviewed the estimated costs imposed by use of overweight (OW) : vehicles and ways to allocate costs to different vehicle classes...

  1. 14 CFR 23.725 - Limit drop tests.

    Science.gov (United States)

    2010-01-01

    ... used in the drop test (lbs.); h=specified free drop height (inches); d=deflection under impact of the tire (at the approved inflation pressure) plus the vertical component of the axle travel relative to... must be made on the complete airplane, or on units consisting of wheel, tire, and shock absorber, in...

  2. Research Article Special Issue

    African Journals Online (AJOL)

    pc

    2017-08-08

    Aug 8, 2017 ... since they do not contain electric-chemical protection and are not subjected to flaw detection during construction and operation. Thus, nowadays many settlements of Russia have ..... in the railroad car axles by acoustic parameters. Zavodskaya Laboratoriya. Diagnostika. Materialov, 70 (3), 2004, pp. 34-38.

  3. Development of a control model for a four wheel mecanum vehicle

    CSIR Research Space (South Africa)

    De Villiers, M

    2012-01-01

    Full Text Available in this paper accounts for the fact that the contact point in fact changes position down the axle of the wheel as the angle roller moves on the ground. The developed control model is verified with experimental results. Using the refined model, control of Mecanum...

  4. Thermal Sensor and Current Generator.

    Science.gov (United States)

    In a system to prevent train derailment due to axle failure resulting from journal bearing overheating, a thermal sensor continuously monitors the...the journal bearing housing physically deforms to activate a power source. The resulting signal initiates an electro-explosive brake line venting

  5. 14 CFR 29.725 - Limit drop test.

    Science.gov (United States)

    2010-01-01

    ...=ratio of assumed rotor lift to the rotorcraft weight. d=deflection under impact of the tire (at the proper inflation pressure) plus the vertical component of the axle travel (inches) relative to the drop mass. n=limit inertia load factor. n j=the load factor developed, during impact, on the mass used in...

  6. Roodekrans trial sections: The role of structural support under very thin jointed CRC pavements subjected to heavy traffic

    CSIR Research Space (South Africa)

    Steyn, WJvdM

    2005-08-01

    Full Text Available on the exit road from a quarry and have successfully sustained 4000 equivalent 80 kN axle loads to date. The concrete pavement thickness varied from 50 mm to 140 mm and the base support consisted of either a natural or stabilized gravel layer 100 mm thick...

  7. Pneumatic stepper motor and device comprising at least one such pneumatic stepper motor

    NARCIS (Netherlands)

    Groenhuis, Vincent; Siepel, Françoise Jeanette; Stramigioli, Stefano

    2018-01-01

    The invention relates to a pneumatic stepper motor, comprising: - a housing, said housing accommodating at least part of: - a rack or geared axle comprising a plurality of gear elements; and - two pistons, each comprising at least two teeth, said pistons being arranged to cooperate with said rack or

  8. 40 CFR 86.142-90 - Records required.

    Science.gov (United States)

    2010-07-01

    ... (Vmix) for each phase of the exhaust test. (n) The humidity of the dilution air. Note: If conditioning....142-90 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... configuration, axle ratio, car line, system miles, idle rpm, and drive wheel tire pressure, as applicable. (g...

  9. Development of Motorized Oil Palm Fruit Rotary Digester | Asoiro ...

    African Journals Online (AJOL)

    A motorized oil palm fruit rotary digester comprising of a feed hopper, hammers, axle, screening plate, v-belt, 2hp electric motor, digesting chamber and frame was designed and developed using standard and locally sourced materials. The performance test analysis showed that its throughput capacity is 117.93kg/hr with a ...

  10. Comparison of the Dynamic Response of One- and Two-Dimensional Models for an Embedded Railway Track to a Moving Load,

    NARCIS (Netherlands)

    Shamalta, M.; Metrikine, A.V.

    2002-01-01

    In this paper, the steady-state response of an embedded track to the axle loading of a moving train is studied theoretically using two models. The first and the second models are one-dimensional (1D) and two-dimensional (2D), respectively, and differ by the fact that the latter model accounts for

  11. On the interaction between wheels and rails in railway dynamics

    DEFF Research Database (Denmark)

    Slivsgaard, Eva Charlotte

    for the track: A simple model of the whole track as one rigid body following each wheelset. An elastic model where the rails are modelled as Euler-Bernoulli beams discretely supported by rigid sleepers. The simple model is used to find the influence of a flexible track on the dynamics of the single-axle bogie...

  12. Heavy Haul Access to U.S. Ports.

    Science.gov (United States)

    2017-10-01

    Texas exporters are increasingly concerned that current overweight regulations do not allow for the full use of the capacity of oceangoing containers. Even with an over-axle/over-gross weight tolerance permit (also known as the HB 2060 permit), the o...

  13. Self Healing of Asphalt Mixtures : Towards a Better Understanding of the Mechanism

    NARCIS (Netherlands)

    Qiu, J.

    2012-01-01

    Traffic is increasing rapidly in terms of number of vehicles and also in axle loads. In order to maximize the availability of the pavement and to minimize hindrances to traffic because of maintenance works, long life pavements are needed. An asphalt pavement with self repairing capabilities is

  14. Provincial road condition and round wood timber transport in South ...

    African Journals Online (AJOL)

    The context of the study is the concern over declining provincial road conditions due to insufficient government funding for road maintenance. The roads are used by a wide variety of commercial and private interests that contribute a broad range of axle loads. There is no information available on the use of these roads, nor ...

  15. Förster resonance energy transfer by formation of a mechanically interlocked [2]rotaxane

    NARCIS (Netherlands)

    Ogoshi, T.; Yamafuji, D.; Yamagishi, T.; Brouwer, A.M.

    2013-01-01

    A[2]rotaxane has been constructed from a di-pyrene appended pillar[5]arene wheel, a pyridinium axle, and a perylene stopper. It shows efficient Forster resonance energy transfer from pyrene to perylene by formation of a mechanically interlocked [2]rotaxane.

  16. Fixed-bed column adsorption of methyl blue using carbon derived ...

    African Journals Online (AJOL)

    Axle Wood Carbon (AWC) was used to study the removal of Methyl Blue (MB) from its aqueous solution in a fixed-bed column adsorption system. The adsorbent (AWC) was characterized using SEM and pHPZC. SEM revealed the surface morphology and from the pHPZC determination, it was found that at pH of 8.21 the ...

  17. 77 FR 60285 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-03

    ... damage and cracks at the pivot joint location of the main landing gear (MLG) inner cylinder/truck beam... gear (MLG) cylinder/truck beam. We are issuing this AD to detect and correct cracking in the MLG center... outer diameter chrome on the center axles of the MLG for chicken- wire cracks, corrosion, and chrome...

  18. The Costs of Using Draft Animals for Sustainable Agricultural ...

    African Journals Online (AJOL)

    The area with tradition in cattle keeping has advantage of low cost by 39% less as compared to area with little tradition. It was concluded that animal traction technology is more suitable both socially and economically viable for farmers with tradition in animal keeping. Other technologies such as the use of single axle tractors ...

  19. use of x-ray fluorescence spectrometry to determine trace elements ...

    African Journals Online (AJOL)

    NIJOTECH

    In these applications, very high purity is required of graphite. Impurity atoms, especially those with large neutron absorption cross- sections must be kept down to ... generator supplied the required high voltage. The turn-table consisted of two pairs of worm and worm-wheel segments rotating about a common axle. The larger ...

  20. Better Seals for Vacuum Bags

    Science.gov (United States)

    Penn, B.; Clemons, J. M.

    1983-01-01

    Roller tool spreads even layer of adhesive. Tool easily constructed from metal, plastic, or wood. Sewing-thread spool serves as roller, nail as axle, and jigsawed block of wood as handle. Tool rolled and pressed against plastic film to assure even layer of adhesive around periphery.

  1. Complex eigenvalue analysis of railway wheel/rail squeal

    African Journals Online (AJOL)

    DR OKE

    the effect of parameters such as friction coefficient, wheel/rail contact position, axle load, etc. on unstable vibration was examined. 2. Squeal Noise Tests. Figure 1 shows ..... static and dynamic behaviour of the wheel/rail depends on the boundary conditions and the constraints by springs. So the analysis was performed for ...

  2. 40 CFR 600.507-12 - Running change data requirements.

    Science.gov (United States)

    2010-07-01

    ... fuel economy and/or energy consumption, as applicable. (b)(1) The additional running change fuel....507-12 Section 600.507-12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY... larger (or, optionally, 10 percent smaller) than the largest axle ratio tested. (ii) Increasing (or...

  3. The economics of potential reduction of the rural road system in Kansas : technical summary.

    Science.gov (United States)

    2011-11-01

    The increasing size of farms in Kansas has led to increasing farm vehicle size as well. Tractor and combine weight and width has increased and the majority of farmers deliver their grain in semi-trucks. Tandem axle trucks are used to deliver farm sup...

  4. Energy recuperation in fully electric vehicles subject to stability and drivability requirements

    NARCIS (Netherlands)

    Ólafsdóttir, J.M.; Lidberg, M.; Falcone, P.; Iersel, S. van; Jansen, S.T.H.

    2012-01-01

    This paper presents a combined control and estimation framework for energy recuperation in fully electric vehicles. We consider a fully electric powertrain, with a driven front axle operating on low friction road surfaces. Our objective is to find the blending of regenerative and friction braking

  5. Development of a vehicle load control strategy for Malawi for the period 2016 to 2020

    CSIR Research Space (South Africa)

    Roux, MP

    2016-07-01

    Full Text Available nationwide survey to assess the extent of the overloading problem on the paved road network; b) Review and update the 2005 “Vehicle Weights and Axle Load Control Strategy”, based on the outcome of this survey; c) Produce a Five-year Implementation (Business...

  6. A Review on the Incidence, Interaction, and Future Perspective on ...

    African Journals Online (AJOL)

    through their anti-TIM-1 and anti-AXL antibodies, hence serving as a potential target for ZIKV drug development. .... of Yap residents above 3 years of age were infested with ZIKV. [5,54,30]. Australia. 1. 2013. Imported cases (ex-Thailand). [8]. Philippines. 1. 2012. Indonesia. 1. 17 ...... Wilson C. Waging war on mosquitoes.

  7. Every Day a New 3D Printing Material

    Science.gov (United States)

    Hughes, Bill; Mona, Lynn; Wilson, Greg; Seamans, Jeff; McAninch, Steve; Stout, Heath

    2017-01-01

    A handful of technological episodes: fire, wheel and axle, Industrial Revolution, Faraday's discovery of electromagnetic induction, the transistor, and the digital age, have historically altered humanity. We are now witnessing/participating in the next transformational technology: 3D printing. Although dating back nearly 30 years, the technology…

  8. Sequence Classification: 891153 [

    Lifescience Database Archive (English)

    Full Text Available calized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the deliv...ery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; Erv14p || http://www.ncbi.nlm.nih.gov/protein/6321384 ...

  9. 14 CFR 25.733 - Tires.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Landing Gear § 25.733 Tires. (a) When a landing gear axle is fitted with a single wheel and tire assembly, the wheel must be fitted with a... reaction. This nose tire load may not exceed 1.5 times the load rating of the tire. (c) When a landing gear...

  10. The Effect of Friction in Pulleys on the Tension in Cables and Strings

    Science.gov (United States)

    Martell, Eric C.; Martell, Verda Beth

    2013-01-01

    Atwood's machine is used in countless introductory physics classes as an illustration of Newton's second law. Initially, the analysis is performed assuming the pulley and string are massless and the axle is frictionless. Although the mass of the pulley is often included when the problem is revisited later in the context of rotational dynamics, the…

  11. 16 CFR 1512.18 - Tests and test procedures.

    Science.gov (United States)

    2010-01-01

    ... measured in the same units on a linear scale. Compute the ratio A for each combination of entrance angle... of a bicycle wheel rim. The rim is rotated about the axle at a linear velocity of 0.23 m/sec (9 in... material into a horizontal plane as it passes beneath the abrading brush. A drive mechanism to rotate the...

  12. Preliminary Assessment of Overweight Mainline Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Siekmann, Adam [ORNL; Capps, Gary J [ORNL; Lascurain, Mary Beth [ORNL

    2011-11-01

    The Federal Motor Carrier Safety Administration requested information regarding overweight and oversized vehicle traffic entering inspection stations (ISs) in order to develop strategies for future research efforts and possibly help guide regulatory issues involving overweight commercial motor vehicles (CMVs). For a period of one month, inspection stations in Knox County and Greene County, Tennessee, recorded overweight and oversized vehicles that entered these ISs. During this period, 435 CMVs were recorded using an electronic form filled out by enforcement personnel at the IS. Of the 435 CMVs recorded, 381 had weight information documented with them. The majority (52.2%) of the vehicles recorded were five-axle combination vehicles, and 50.6% of all the vehicles were permitted to operate above the legal weight limit in Tennessee, which is 80,000 lb for vehicles with five or more axles. Only 16.8% of the CMVs recorded were overweight gross (11.5% of permitted vehicles) and 54.1% were overweight on an axle group. The low percentage of overweight gross CMVs was because only 45 of the vehicles over 80,000 lb. were not permitted. On average, axles that were overweight were 2,000 lb. over the legal limit for an axle or group of axles. Of the vehicles recorded, 172 vehicles were given a North American Standard (NAS) inspection during the assessment. Of those, 69% of the inspections were driver-only inspections (Level III) and only 25% of the inspections had a vehicle component (such as a Level I or Level II). The remaining 6% of inspections did not have valid Aspen numbers; the type of was inspection unknown. Data collected on the types of trailers of each vehicle showed that about half of the recorded CMVs could realistically be given a Level I (full vehicle and driver) inspection; this estimate was solely based on trailer type. Enforcement personnel at ISs without an inspection pit have difficulty fully inspecting certain vehicles due to low clearance below the trailer

  13. Application of WIM to pavement design. Effect of WIM accuracy

    Directory of Open Access Journals (Sweden)

    J. Leal Bermejo

    2017-03-01

    Full Text Available Weigh-in-motion (WIM techniques can provide data on vehicle and axle weights when they are travelling at full highway speeds. In this paper, the application of WIM data to the design of road pavements is described and the effect of WIM load data accuracy on the estimate of pavement service life is analysed. Thus, the main factors affecting WIM accuracy are explained, especially those related to vehicle-pavement interaction. Afterwards, a trial that has been conducted to evaluate the effect of WIM load data accuracy on pavement life prediction will be presented. The results obtained show that the errors in axle load measurements can lead to higher errors in pavement life estimates.

  14. Fast tracking using edge histograms

    Science.gov (United States)

    Rokita, Przemyslaw

    1997-04-01

    This paper proposes a new algorithm for tracking objects and objects boundaries. This algorithm was developed and applied in a system used for compositing computer generated images and real world video sequences, but can be applied in general in all tracking systems where accuracy and high processing speed are required. The algorithm is based on analysis of histograms obtained by summing along chosen axles pixels of edge segmented images. Edge segmentation is done by spatial convolution using gradient operator. The advantage of such an approach is that it can be performed in real-time using available on the market hardware convolution filters. After edge extraction and histograms computation, respective positions of maximums in edge intensity histograms, in current and previous frame, are compared and matched. Obtained this way information about displacement of histograms maximums, can be directly converted into information about changes of target boundaries positions along chosen axles.

  15. Dynamic Response of Wheel-Rail Interaction at Rail Weld in High-Speed Railway

    Directory of Open Access Journals (Sweden)

    Boyang An

    2017-01-01

    Full Text Available As a main part of continuously welded rail track, rail weld widely exists in high-speed railway. However, short-wave irregularities can easily initiate and develop in rail weld due to the limitation of welding technology and thus rail weld has been a main high-frequency excitation and is responsible for deterioration of track components. This work reports a 3D finite element model of wheel-rail rolling contact which can simulate dynamic wheel-rail interaction at arbitrary contact geometry up to 400 km/h. This model is employed to investigate dynamic response of wheel-rail interaction at theoretical and measured rail weld, including wheel-rail force and axle-box acceleration. These simulation results, combined with Quality Index (QI method, are used to develop a quantitative expression, which can be easily applied for evaluating rail weld deterioration based on measured rail profiles and axle-box acceleration.

  16. Structural Elucidation of the DFG-Asp in and DFG-Asp out States of TAM Kinases and Insight into the Selectivity of Their Inhibitors

    Directory of Open Access Journals (Sweden)

    Abdellah Messoussi

    2014-10-01

    Full Text Available Structural elucidation of the active (DFG-Asp in and inactive (DFG-Asp out states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in and DFG-Asp out homology models of each one were built based on the X-ray structure of c-Met kinase, an enzyme with a closely related sequence. Structural validation and in silico screening enabled identification of critical amino acids for ligand binding within the active site of each DFG-Asp in and DFG-Asp out model. The position and nature of amino acids that differ among Tyro-3, Axl and Mer, and the potential role of these residues in the design of selective TAM ligands, are discussed.

  17. How Secondary and Tertiary Amide Moieties are Molecular Stations for Dibenzo-24-crown-8 in [2]Rotaxane Molecular Shuttles?

    Directory of Open Access Journals (Sweden)

    Benjamin Riss-Yaw

    2017-11-01

    Full Text Available Interlocked molecular machines like [2]rotaxanes are intriguing aesthetic molecules. The control of the localization of the macrocycle, which surrounds a molecular axle, along the thread leads to translational isomers of very different properties. Although many moieties have been used as sites of interactions for crown ethers, the very straightforwardly obtained amide motif has more rarely been envisaged as molecular station. In this article, we report the use of secondary and tertiary amide moieties as efficient secondary molecular station in pH-sensitive molecular shuttles. Depending on the N-substitution of the amide station, and on deprotonation or deprotonation-carbamoylation, the actuation of the molecular machinery differs accordingly to very distinct interactions between the axle and the DB24C8.

  18. Dynamic Measurement for the Diameter of A Train Wheel Based on Structured-Light Vision

    Directory of Open Access Journals (Sweden)

    Zheng Gong

    2016-04-01

    Full Text Available Wheels are very important for the safety of a train. The diameter of the wheel is a significant parameter that needs regular inspection. Traditional methods only use the contact points of the wheel tread to fit the rolling round. However, the wheel tread is easily influenced by peeling or scraping. Meanwhile, the circle fitting algorithm is sensitive to noise when only three points are used. This paper proposes a dynamic measurement method based on structured-light vision. The axle of the wheelset and the tread are both employed. The center of the rolling round is determined by the axle rather than the tread only. Then, the diameter is calculated using the center and the contact points together. Simulations are performed to help design the layout of the sensors, and the influences of different noise sources are also analyzed. Static and field experiments are both performed, and the results show it to be quite stable and accurate.

  19. Dynamic Pseudorotaxane Crystals Containing Metallocene Complexes.

    Science.gov (United States)

    Chen, Kai-Jen; Chen, Pei-Lin; Horie, Masaki

    2017-10-27

    Molecular machines and switches composed of flexible pseudorotaxanes respond to external stimuli, transducing incident energy into mechanical motions. This study presents thermo- and photoresponsive dynamic pseudorotaxane crystals composed of axle molecules containing ferrocene or ruthenocene groups threaded through dibenzo[24]crown-8 ether rings. The ruthenocene-containing pseudorotaxane exhibits a crystal-to-crystal thermal phase transition at 86 °C, which is much lower than that of the ferrocene-containing pseudorotaxane (128 °C). Single-crystal X-ray crystallography at various temperatures reveals the details of the structural changes, and shows that the bulky ruthenocene provides distortion in the pseudorotaxane structure to facilitate twisting of the axle molecule. A mixed ferrocene and ruthenocene pseudorotaxane crystal is applied to photomechanical conversion under 405 nm laser irradiation at 85 °C and provides a lifting force 6,400-times the weight of the crystal itself upon phase transition.

  20. Marginal overweight operating scenario for DOE's initiative I highway casks

    International Nuclear Information System (INIS)

    Hill, C.V.; Loud, G.C.; Heitzman, A.C.

    1993-01-01

    This paper assesses the potential transport of high-capacity Initiative I highway casks under development by the Office of Civilian Radioactive Waste Management (OCRWM) as permitted marginal overweight shipments that: exceed a gross vehicle weight (gvw) limit of 80,000, but weight less than 96,000 pounds; follow axle and axle group weight limits adopted by the Surface Transportation Assistance Act (STAA) of 1982; conform to dimensional restrictions to operate on most major highways; and comply with the Federal Bridge Formula. The marginal overweight tractor-trailer would operate in normal open-quotes over-the-roadclose quotes mode and comply with all laws and regulations. The vehicle would have a sleeper berth and two drivers - one to drive while the other provides escort and communications services and accumulates required off-duty time

  1. How Secondary and Tertiary Amide Moieties are Molecular Stations for Dibenzo-24-crown-8 in [2]Rotaxane Molecular Shuttles?

    Science.gov (United States)

    Riss-Yaw, Benjamin; Morin, Justine; Clavel, Caroline; Coutrot, Frédéric

    2017-11-21

    Interlocked molecular machines like [2]rotaxanes are intriguing aesthetic molecules. The control of the localization of the macrocycle, which surrounds a molecular axle, along the thread leads to translational isomers of very different properties. Although many moieties have been used as sites of interactions for crown ethers, the very straightforwardly obtained amide motif has more rarely been envisaged as molecular station. In this article, we report the use of secondary and tertiary amide moieties as efficient secondary molecular station in pH-sensitive molecular shuttles. Depending on the N -substitution of the amide station, and on deprotonation or deprotonation-carbamoylation, the actuation of the molecular machinery differs accordingly to very distinct interactions between the axle and the DB24C8.

  2. Principle of maximum entropy for reliability analysis in the design of machine components

    Science.gov (United States)

    Zhang, Yimin

    2018-03-01

    We studied the reliability of machine components with parameters that follow an arbitrary statistical distribution using the principle of maximum entropy (PME). We used PME to select the statistical distribution that best fits the available information. We also established a probability density function (PDF) and a failure probability model for the parameters of mechanical components using the concept of entropy and the PME. We obtained the first four moments of the state function for reliability analysis and design. Furthermore, we attained an estimate of the PDF with the fewest human bias factors using the PME. This function was used to calculate the reliability of the machine components, including a connecting rod, a vehicle half-shaft, a front axle, a rear axle housing, and a leaf spring, which have parameters that typically follow a non-normal distribution. Simulations were conducted for comparison. This study provides a design methodology for the reliability of mechanical components for practical engineering projects.

  3. Repeated Load Permanent Deformation Behavior of Mixes With and Wihtout Modified Bituments

    Directory of Open Access Journals (Sweden)

    Imran Hafeez

    2011-01-01

    Full Text Available Premature rutting in flexible pavement structure is being observed on most of the road network of Pakistan. It initiates primarily due to uncontrolled axle loading and high ambient temperatures. NHA (National Highway Authority, Pakistan has continuously been modifying aggregate gradations and penetration grade of bitumen, without any prior investigation of the mix behaviour under the prevailing axle load and environmental conditions of the country. A comprehensive laboratory investigation was carried out on six mixes ranging from finer to coarser. Specimens were subjected to cyclic loading on UTM-5P (Universal Testing Machine to study the resistance against permanent deformation of the mixes at 25, 40 and 550C. At low temperatures and stress levels, both coarse and fine graded mixes showed less accumulated strain, whereas at higher temperatures and stress levels, coarse graded mix with PMB (Polymer Modified Bitumen showed good resistance to permanent deformation.

  4. Longitudinal velocity and road slope estimation in hybrid electric vehicles employing early detection of excessive wheel slip

    Science.gov (United States)

    Klomp, Matthijs; Gao, Yunlong; Bruzelius, Fredrik

    2014-05-01

    Vehicle speed is one of the important quantities in vehicle dynamics control. Estimation of the slope angle is in turn a necessity for correct dead reckoning from vehicle acceleration. In the present work, estimation of vehicle speed is applied to a hybrid vehicle with an electric motor on the rear axle and a combustion engine on the front axle. The wheel torque information, provided by electric motor, is used to early detect excessive wheel slip and improve the accuracy of the estimate. A best-wheel selection approach is applied as the observation variable of a Kalman filter which reduces the influence of slipping wheels as well as reducing the computational effort. The performance of the proposed algorithm is illustrated on a test data recorded at a winter test ground with excellent results, even for extreme conditions such as when all four wheels are spinning.

  5. Technical study for inflector and central region of high intensity central region model cyclotron

    International Nuclear Information System (INIS)

    Yao Hongjuan; Lu Yinlong; Zhang Tianjue; Li Zhenguo; Jia Xianlu; Guan Fengping; Wang Zhenhui; Lin Jun; Lin Yuzheng

    2008-01-01

    The central region model (CRM) cyclotron is the experimental platform for the key technology study of a high intensity beam cyclotron. In thia paper we introduce the spiral inflector and central region designed for the CRM cyclotron, including the physical design, the numerical control machining and the installation precision control techniques. The shape of electrodes is complex, and machining with a strict tolerance must be done by a numerical control machine tool with the number of its axles no less that 4. The electrodes of central region were finished by using 3-axle machine tools. The size of gaps between the ground and Dee tip is very important, a special device was made to guarantee the installation precision, and the error of gaps was controlled within ±0.05 mm. (authors)

  6. Increasing the Efficiency of Railway Transport by Improvement of Suspension of Freight Wagons

    Directory of Open Access Journals (Sweden)

    Dragan Petrović

    2012-11-01

    Full Text Available Railway transport has a very important role in economy of every country. The efficiency of railway transport depends both on the quality of transport organization and on the technical reliability of the railway rolling stock. During operation of the railway freight wagons in the last years, a large number of breaks of suspension system elements have been noticed. This feature is especially reported at four-axle double wagon for coal transport (designated Fbd and three-axle wagon for transport of cars (designated DDam. Frequent breaks of suspension system elements reduce the efficiency of transport and in some cases cause derailment of wagons and lead to large economic losses. In this paper, the causes of breakage of suspension on both wagons (Fbd and DDam have been analyzed, but also the possibilities of how to resolve these problems, i.e. how to reduce them to a minimum or avoid them completely.

  7. Obstacles and improvements to get a university professor of science an argumentative participation students

    Directory of Open Access Journals (Sweden)

    John Jairo Briceño-Martínez

    2017-05-01

    Full Text Available Research results of a formative investigation process of twelve hours are shown in this paper. The main purpose of this investigation is to guide and walk a university professor (AXL to design and implement activities that promote argumentative participation of his students throughout a process that is called supervision. This research is a case study based on three nonparticipating observations, in which it is investigated the effect and impact that teachers’ participation in argumentative talks have in students. It is concluded that AXL learned how to drive students into the argumentative process and promoted participation in the classroom; however, despite the effort of the teacher, his/her students neither reached nor achieved the expected argumentative level in spite of their participation.

  8. Learning the Lessons of Leadership: Case Method Teaching with Interactive Computer-Based Tools and Film-Based Cases

    Science.gov (United States)

    2008-03-01

    Institute for the Behavioral and Socia Sc’ ,ices (ARI), including Dr. Michelle Sams and Dr. Zita Simutis, and especially its Fort Leave’ "orth Research...through a process of analysis and reflection of those experiences. Specifically, AXL provides an online, media -rich environment for delivering case...points of view (Kutner, Greenburg, & Baer, 2005). Thus, case study materials that are presented through media other than the written form can create an

  9. Epithelial Plasticity in Castration-Resistant Prostate Cancer: Biology of the Lethal Phenotype

    Science.gov (United States)

    2014-07-01

    and suggestions for ther- apeutic interventions to address EP in PC. Cancer Metastasis Rev 2 Preclinical evidence of EP in PC EP in epithelial-origin...Szabadkai, I., Daub, H., Keri, G., & Ullrich, A. (2008). AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer ... Testicular Cancer Lecture and 2011 Prostate Cancer Lecture 11.2010 Talk entitled: “CRPC: What Else is Out There?” for the UK Cancer Convention, Royal

  10. Slab track systems for high-speed railways.

    OpenAIRE

    Michas, Georgios

    2012-01-01

    In the last 40 years an increase in train speed and axle load around the world and other challenges in the conventional ballasted track system gave birth to ballastless railway track system. This study examines in depth the various slab track systems that are being used today. Their design characteristics as well as the various requirements for efficient use are thoroughly explained. At least 34 different ballastless systems have been recorded in many railway networks throughout the world. Th...

  11. Economic Effects of Lifting the Spring Load Restriction Policy in Minnesota

    OpenAIRE

    Smalkoski, Brian; Li, Ning; Levinson, David

    2006-01-01

    Spring load restrictions (SLR) regulate the weight per axle carried by heavy trucks during the spring thaw period. This policy aims to reduce pavement damage caused by heavy vehicles and extend the useful life of roads, but it also imposes costs on the trucking industry due to detouring or increased number of truckloads. Although the policies have been implemented for many years, their resulting economic effect has been unclear. The Minnesota Local Road Research Board (LRRB) and the Minnesota...

  12. A Nontoxic Barlow's Wheel

    Science.gov (United States)

    Daffron, John A.; Greenslade, Thomas B., Jr.

    2015-01-01

    Barlow's wheel has been a favorite demonstration since its invention by Peter Barlow (1776-1862) in 1822. In the form shown in Fig. 1, it represents the first electric motor. The interaction between the electric current passing from the axle of the wheel to the rim and the magnetic field produced by the U-magnet produces a torque that turns…

  13. A Framework for Evidence-Based Licensure of Adaptive Autonomous Systems

    Science.gov (United States)

    2016-03-01

    purposes. The constraints on the activity are an important part of the license— motorcycles or buses require separate licenses from two-axle vehicles...and a basic license does not permit operating a commercial limo service . Licenses are typically based on established evidence that gives the licensing...refer to a mechanism for assessing the desirability of a particular observed system behavior as a normative oracle. A normative oracle provides a process

  14. Light and Heavy Tactical Wheeled Vehicle Fuel Consumption Evaluations Using Fuel Efficient Gear Oils (FEGO)

    Science.gov (United States)

    2016-05-01

    Engine oil and filter change • Transmission fluid and filter change • Front and rear axle/differential fluid change • Air and fuel filter change...Prior to commencing with testing the following preparations were made to the vehicles. 1. All wheels were aligned. 2. The engine air filters and...fuel filters were replaced. 3. The engine , transmission, and transfer case fluids were changed. 4. A separate weigh tank was connected to each

  15. Optimized Design and Testing of a Prototype Military Bridge System for Rapid In-Theater Construction

    Science.gov (United States)

    2006-11-01

    MLC 30 were applied to the system with multiple load cases for each axle, truck, and track loading. The load cases were applied sequentially to...flexural failure due to concrete crushing along the center of slab span. The failure was identified with center span cracking and associated concrete...Layer Prefabricated FRP Grids for Rapid Bridge Deck Construction: Case Study. ASCE Journal of Composites for Construction, 10, 201-121. Berg, A. C

  16. Steered wheel for the support and/or steering of a vehicle, particularly hovercraft

    Energy Technology Data Exchange (ETDEWEB)

    Duell, H.J.; Kirchner, G.

    1977-04-07

    The invention concerns a steered wheel for the support or steering of a hovercraft, whose wheel suspension is provided with an eccentric journal for automatic setting in the direction of travel. So that the vehicle will not leave its track during changes of direction when the wheel is turned around the eccentric axis, according to the invention the wheel is supported on movable bearings at the journal in the direction of the driving axle.

  17. Toward Theoretical Foundations of Resistive Force Theory of Granular-Structural Interaction, with Expansions to Flexible Locomotors

    Science.gov (United States)

    2015-05-07

    Terramechanics, terradynamics, plasticity, soils , computation REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10. SPONSOR/MONITOR’S...has shown that under certain conditions, the natural curvature of a wheel tread under axle-bearing weight is proper to improve traction in soils . (a...orientations moving to the right. Top row: FEM simulations of the continuum model. Bottom row: DEM simulations of [3]. Velocity arrows corresponding to

  18. Research of cost aspects of cement pavements construction

    Science.gov (United States)

    Bezuglyi, Artem; Illiash, Sergii; Tymoshchuk, Oleksandr

    2017-09-01

    The tendency to increasing traffic volume on public roads and to increased axle loads of vehicles makes the road scientists to develop scientifically justified methods for preserving the existing and developing the new transport network of Ukraine. One of the options for solving such issues is the construction of roads with rigid (cement concrete) pavement. However, any solution must be justified considering technical and economic components. This paper presents the results of the research of cost aspects of cement pavements construction.

  19. Dynamic Pseudorotaxane Crystals Containing Metallocene Complexes

    OpenAIRE

    Chen, Kai-Jen; Chen, Pei-Lin; Horie, Masaki

    2017-01-01

    Molecular machines and switches composed of flexible pseudorotaxanes respond to external stimuli, transducing incident energy into mechanical motions. This study presents thermo- and photoresponsive dynamic pseudorotaxane crystals composed of axle molecules containing ferrocene or ruthenocene groups threaded through dibenzo[24]crown-8 ether rings. The ruthenocene-containing pseudorotaxane exhibits a crystal-to-crystal thermal phase transition at 86 °C, which is much lower than that of the fer...

  20. Development of a Novel Method to Detect Prostate Cancer Circulating Tumor Cells (CTCs) Based on Epithelial-Mesenchymal Transition Biology

    Science.gov (United States)

    2015-12-01

    promotes cell cycle arrest and apoptosis [52, 53]. Mutations in p53 are common in cancer cells, are responsible for the functional loss of the tumor...and Stat3 are required for survival of intestinal epithelial cells and development of colitis- associated cancer. Cancer Cell, 15, 103–113. 101...M., Muigg, A., Kostron, H., Stockhammer, G., & Ullrich, A. (2008). Axl and growth arrest -specific gene 6 are frequently overexpressed in hu- man

  1. Catalog of components for electric and hybrid vehicle propulsion systems

    Science.gov (United States)

    Eissler, H. C.

    1981-01-01

    This catalog of commercially available electric and hybrid vehicle propulsion system components is intended for designers and builders of these vehicles and contains 50 categories of components. These categories include those components used between the battery terminals and the output axle hub, as well as some auxiliary equipment. An index of the components and a listing of the suppliers and their addresses and phone numbers are included.

  2. Corneal K-Values as a Diagnostic Screening Tool for Marfan Syndrome.

    Science.gov (United States)

    Luebke, Jan; Boehringer, Daniel; Eberwein, Philipp; Reinhard, Thomas

    2017-06-01

    Marfan syndrome (MFS) is diagnosed based on Ghent nosology, including major and minor criteria such as increased axial length (AXL) and flattened corneal curvature (higher K-values) or myopia of more than -3 diopters (D) in its latest revision. Because corneal flattening may, in part, be caused by AXL increase, it may be helpful to consider K-values separately. We present statistical evaluation of using corneal K-values for identifying MFS. A retrospective study of K-values of 74 right eyes of 74 patients with MFS, who were compared with an age- and AXL-matched group of 74 right eyes of 74 patients without MFS. After multivariate analysis, receiver operating characteristic curves were calculated. Mean age was 44.1 years versus 44.9 years (P = 0.834). Mean AXL was 25.22 mm versus 25.47 mm (P = 0.661). K-values showed significant differences: mean Kmax was 8.25 mm (40.91 D) versus 7.9 mm (42.72 D) (P < 0.001) and mean Kmin was 8.22 mm (41.06 D) versus 7.69 mm (43.89 D) (P < 0.001). The area under the curve in receiver operating characteristic analysis was 0.82 for Kmax and 0.78 for Kmin; the best cutoff was seen at a Kmax of at least 8.16 mm (41.36 D; sensitivity 73% and specificity 81%). Although both K-values differ significantly, Kmax is the better marker to identify MFS. A Kmax of more than 8.16 mm (41.36 D) seems to be a reasonable cutoff (specificity of 81% and sensitivity of 73%). Because this biometric value is easily obtained and standardized, we see it as a good supporting screening tool for MFS suspects.

  3. Peripheral Retinal Vascular Patterns in Patients with Rhegmatogenous Retinal Detachment in Taiwan

    Science.gov (United States)

    Chen, San-Ni; Hwang, Jiunn-Feng; Wu, Wen-Chuan

    2016-01-01

    This is an observational study of fluorescein angiography (FA) in consecutive patients with rhegmatogenous retinal detachment (RRD) in Changhua Christian Hospital to investigate the peripheral retinal vascular patterns in those patients. All patients had their age, sex, axial length (AXL), and refraction status (RF) recorded. According to the findings in FA of the peripheral retina, the eyes were divided into 4 groups: in group 1, there was a ramified pattern of peripheral retinal vasculature with gradual tapering; in group 2, there was an abrupt ending of peripheral vasculature with peripheral non-perfusion; in group 3, there was a curving route of peripheral vasculature forming vascular arcades or anastomosis; and in group 4, the same as in group 3, but with one or more wedge-shaped avascular notches. Comparisons of age, sex, AXL, and RF, association of breaks with lattice degeneration and retinal non-perfusion, surgical procedures utilized, and mean numbers of operations were made among the four groups. Of the 73 eyes studied, there were 13 eyes (17.8%) in group 1, 3 eyes (4.1%) in group 2, 40 eyes (54.8%) in group 3 and 17 eyes (23.3%) in group 4. Significant differences in age, AXL and RF, and association of retinal breaks to non-perfusion were noted among the four groups. Patients in group 1 had older ages, while younger ages were noted in groups 3 and 4. Eyes in group 1 had the shortest average AXL and were least myopic in contrast to the eyes in groups 3 and 4. Association of retinal breaks and retinal non-perfusion was significantly higher in groups 2, 3 and 4 than in group 1. In conclusion, peripheral vascular anomalies are common in cases with RRD. Patients with peripheral non-perfusion tend to be younger, with longer axial length and have the breaks associated with retinal non-perfusion. PMID:26909812

  4. Peripheral Retinal Vascular Patterns in Patients with Rhegmatogenous Retinal Detachment in Taiwan.

    Directory of Open Access Journals (Sweden)

    San-Ni Chen

    Full Text Available This is an observational study of fluorescein angiography (FA in consecutive patients with rhegmatogenous retinal detachment (RRD in Changhua Christian Hospital to investigate the peripheral retinal vascular patterns in those patients. All patients had their age, sex, axial length (AXL, and refraction status (RF recorded. According to the findings in FA of the peripheral retina, the eyes were divided into 4 groups: in group 1, there was a ramified pattern of peripheral retinal vasculature with gradual tapering; in group 2, there was an abrupt ending of peripheral vasculature with peripheral non-perfusion; in group 3, there was a curving route of peripheral vasculature forming vascular arcades or anastomosis; and in group 4, the same as in group 3, but with one or more wedge-shaped avascular notches. Comparisons of age, sex, AXL, and RF, association of breaks with lattice degeneration and retinal non-perfusion, surgical procedures utilized, and mean numbers of operations were made among the four groups. Of the 73 eyes studied, there were 13 eyes (17.8% in group 1, 3 eyes (4.1% in group 2, 40 eyes (54.8% in group 3 and 17 eyes (23.3% in group 4. Significant differences in age, AXL and RF, and association of retinal breaks to non-perfusion were noted among the four groups. Patients in group 1 had older ages, while younger ages were noted in groups 3 and 4. Eyes in group 1 had the shortest average AXL and were least myopic in contrast to the eyes in groups 3 and 4. Association of retinal breaks and retinal non-perfusion was significantly higher in groups 2, 3 and 4 than in group 1. In conclusion, peripheral vascular anomalies are common in cases with RRD. Patients with peripheral non-perfusion tend to be younger, with longer axial length and have the breaks associated with retinal non-perfusion.

  5. Effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography

    Directory of Open Access Journals (Sweden)

    Mohana Kuppuswamy Parthasarathy

    2015-01-01

    Full Text Available Aim: The aim of the present study was to study the effect of ocular magnification on macular measurements made using spectral domain optical coherence tomography (OCT. Materials and Methods: One hundred and fifty-one subjects were included from the normative study of foveal morphology carried out at our hospital. Subjects underwent comprehensive eye examination and macular scanning using Cirrus high-definition OCT and axial length (AXL measurement. Macular cube 512 × 128 scan protocol was used for scanning the macula. Automated measurements of the fovea namely foveal diameter, foveal slope (lateral measurements and foveal depth (axial measurement were taken. A correction factor for ocular magnification was done using the formula t = p × q × s, where "t0" is the corrected measurement, "p" is the magnification of OCT, "q0" is the ocular magnification, and "s" is the measurement on OCT without correction. The difference between corrected and uncorrected measurements was evaluated for statistical significance. Results: Mean AXL was 22.95 ± 0.78 mm. Refractive error ranged from −3D to +4D. Mean difference between measured and corrected foveal diameter, slope and depth was 166.05 ± 95.37 ΅m (P < 0.001, 0.81° ± 0.53° (P < 0.001 and 0.05 ± 0.49 ΅m (P = 0.178 respectively. AXL lesser than the OCT calibrated value of 24.46 mm showed an increased foveal diameter (r = 0.961, P < 0.001 and a reduced foveal slope (r = −0.863, P < 0.001 than the corrected value. Conclusion: Lateral measurements made on OCT varied with AXL s other than the OCT calibrated value of 24.46 mm. Therefore, to estimate the actual dimensions of a retinal lesion using OCT, especially lateral dimensions, we recommend correction for the ocular magnification factor.

  6. Theoretical and experimental research on the phenomenon of stick-slip at traction railway vehicles

    Science.gov (United States)

    Sebesan, Ioan; Manea, Ion; Spiroiu, Marius Adrian; Arsene, Sorin

    2018-01-01

    The stick-slip phenomenon may occur when the limit adhesion force is exceeded at one of the motor axles of the vehicle. In the present paper is analysed the physical phenomenon stick-slip, the conditions for its occurrence and the mechanical model recommended for the study of the phenomenon. Regarding the experimental research, it is presented the stand built in the laboratory of the Rolling Stock Department at Politehnica University of Bucharest.

  7. Changes in inertia and effect on turning effort across different wheelchair configurations

    OpenAIRE

    Jayme J. Caspall, MS; Erin Seligsohn; Phuc V. Dao, MS; Stephen Sprigle, PhD, PT

    2014-01-01

    When executing turning maneuvers, manual wheelchair users must overcome the rotational inertia of the wheelchair system. Differences in wheelchair rotational inertia can result in increases in torque required to maneuver, resulting in greater propulsion effort and stress on the shoulder joints. The inertias of various configurations of an ultralightweight wheelchair were measured using a rotational inertia-measuring device. Adjustments in axle position, changes in wheel and tire type, and the...

  8. Disain Sistem Kontrol Mesin Arc Welding dengan Robot di Housing Assembly Line Menggunakan Sistem Kendali PLC Mitsubishi Q-Series, Robot Controller OTC AX-26, dan CC-Link

    Directory of Open Access Journals (Sweden)

    Syahril Ardi

    2014-10-01

    Full Text Available PT BCD merupakan perusahaan industri manufaktur yang memproduksi rear axle, propeller shaft, front axle, dan transmission assembly. Pada housing assembly (bagian komponen rear axle line manufaktur PT BCD mendapat tambahan pesanan produk dari customer yaitu produk housing assembly tipe D01N. Terdapat beberapa proses yang tidak dapat dijalankan apabila tidak mengganti pekerjaan pada proses tersebut. Salah satunya adalah proses pemasangan bracket small part dengan menggunakan welding penuh yang terdiri dari 2 proses, yaitu proses pada station welding manual dan proses pada station M14 yang menggunakan mesin saddle spring ard by auto. Kondisi inilah yang menyebabkan diperlukannya sebuah mesin yang dapat menjalankan proses pada station M14, proses manual, dan proses untuk model D01N. Mesin yang dapat mengerjakan ketiga proses tersebut adalah mesin welding arc by robot. Rancang bangun sistem kontrol mesin welding arc by robot yang sesuai dengan sequence yang diinginkan juga dibutuhkan untuk menunjang proses pemasangan bracket small part pada produk-produk yang diproduksi di line ini. Mesin welding arc by robot dapat mengatasi permasalahan yang ada, yaitu menunjang proses produksi di housing assembly line khususnya pada proses pemasangan bracket small part, kapasitas produksi tipe D01N meningkat dari 0 menjadi 2000 produk.

  9. Pavement Response to Variable Tyre Pressure of Heavy Vehicles

    Directory of Open Access Journals (Sweden)

    Arshad Ahmad Kamil

    2016-01-01

    Full Text Available In recent years, the effect of overinflated tyre pressure and increased heavy vehicles’ axle load on flexible pavements has become a subject of great concern because of the higher stress levels induced and damage caused to road pavements. This paper aims to evaluate the effect of variable tyre inflation pressures (using actual tyre contact/footprint area to determine the responses of flexible pavement. A full scale experiment was conducted on a heavy vehicle with 1:1:2 axle configuration, 10 R 20 tyre size and attached trailer with constant axle load. Measurements were made for actual tyre-pavement contact area. KENPAVE linear elastic program was then used to analyse the effects of the measured actual tyre-pavement contact area and the results was compared using conventional circular tyre contact area. A comparative analysis was then made between the actual contact area and the conventional circular tyre contact area. It was found that high tyre inflation pressure produce smaller contact area, giving more detrimental effect on the flexible pavement. It was also found that the temperature of tyres when the heavy vehicles are operational give less significant impact on tyre inflation pressure for the Malaysian climate.

  10. Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL

    Directory of Open Access Journals (Sweden)

    Margherita Iaboni

    2016-01-01

    Full Text Available TNF-related apoptosis-inducing ligand (TRAIL is a promising antitumor agent for its remarkable ability to selectively induce apoptosis in cancer cells, without affecting the viability of healthy bystander cells. The TRAIL tumor suppressor pathway is deregulated in many human malignancies including lung cancer. In human non-small cell lung cancer (NSCLC cells, sensitization to TRAIL therapy can be restored by increasing the expression levels of the tumor suppressor microRNA-212 (miR-212 leading to inhibition of the anti-apoptotic protein PED/PEA-15 implicated in treatment resistance. In this study, we exploited a previously described RNA aptamer inhibitor of the tyrosine kinase receptor Axl (GL21.T expressed on lung cancer cells, as a means to deliver miR-212 into human NSCLC cells expressing Axl. We demonstrate efficient delivery of miR-212 following conjugation of the miR to GL21.T (GL21.T-miR212 chimera. We show that the chimera downregulates PED and restores TRAIL-mediate cytotoxicity in cancer cells. Importantly, treatment of Axl+ lung cancer cells with the chimera resulted in (i an increase in caspase activation and (ii a reduction of cell viability in combination with TRAIL therapy. In conclusion, we demonstrate that the GL21.T-miR212 chimera can be employed as an adjuvant to TRAIL therapy for the treatment of lung cancer.

  11. Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL.

    Science.gov (United States)

    Iaboni, Margherita; Russo, Valentina; Fontanella, Raffaela; Roscigno, Giuseppina; Fiore, Danilo; Donnarumma, Elvira; Esposito, Carla Lucia; Quintavalle, Cristina; Giangrande, Paloma H; de Franciscis, Vittorio; Condorelli, Gerolama

    2016-03-08

    TNF-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent for its remarkable ability to selectively induce apoptosis in cancer cells, without affecting the viability of healthy bystander cells. The TRAIL tumor suppressor pathway is deregulated in many human malignancies including lung cancer. In human non-small cell lung cancer (NSCLC) cells, sensitization to TRAIL therapy can be restored by increasing the expression levels of the tumor suppressor microRNA-212 (miR-212) leading to inhibition of the anti-apoptotic protein PED/PEA-15 implicated in treatment resistance. In this study, we exploited a previously described RNA aptamer inhibitor of the tyrosine kinase receptor Axl (GL21.T) expressed on lung cancer cells, as a means to deliver miR-212 into human NSCLC cells expressing Axl. We demonstrate efficient delivery of miR-212 following conjugation of the miR to GL21.T (GL21.T-miR212 chimera). We show that the chimera downregulates PED and restores TRAIL-mediate cytotoxicity in cancer cells. Importantly, treatment of Axl+ lung cancer cells with the chimera resulted in (i) an increase in caspase activation and (ii) a reduction of cell viability in combination with TRAIL therapy. In conclusion, we demonstrate that the GL21.T-miR212 chimera can be employed as an adjuvant to TRAIL therapy for the treatment of lung cancer.

  12. Evaluation of Anterior Chamber Volume in Cataract Patients with Swept-Source Optical Coherence Tomography.

    Science.gov (United States)

    He, Wenwen; Zhu, Xiangjia; Wolff, Don; Zhao, Zhennan; Sun, Xinghuai; Lu, Yi

    2016-01-01

    Purpose. To evaluate the anterior chamber volume in cataract patients with Swept-Source Optical Coherence Tomography (SS-OCT) and its influencing factors. Methods. Anterior chamber volume of 92 cataract patients was evaluated with SS-OCT in this cross-sectional study. Univariate analyses and multiple linear regression were used to investigate gender, age, operated eye, posterior vitreous detachment, lens opacity grading, and axial length (AXL) related variables capable of influencing the ACV. Results. The average ACV was 139.80 ± 38.21 mm(3) (range 59.41 to 254.09 mm(3)). The average ACV was significantly larger in male patients than in female patients (P = 0.001). ACV was negatively correlated with age and LOCS III cortical (C) grading of the lens (Pearson's correlation analysis, r = -0.443, P ACV was also increased with AXL (Pearson's correlation analysis, r = 0.552, P ACV (F = 10.252  P ACV varied significantly among different subjects. Influencing factors that contribute to reduced ACV were female gender, increased age, LOCS III C grade, and shorter AXL.

  13. Sparsity guided empirical wavelet transform for fault diagnosis of rolling element bearings

    Science.gov (United States)

    Wang, Dong; Zhao, Yang; Yi, Cai; Tsui, Kwok-Leung; Lin, Jianhui

    2018-02-01

    Rolling element bearings are widely used in various industrial machines, such as electric motors, generators, pumps, gearboxes, railway axles, turbines, and helicopter transmissions. Fault diagnosis of rolling element bearings is beneficial to preventing any unexpected accident and reducing economic loss. In the past years, many bearing fault detection methods have been developed. Recently, a new adaptive signal processing method called empirical wavelet transform attracts much attention from readers and engineers and its applications to bearing fault diagnosis have been reported. The main problem of empirical wavelet transform is that Fourier segments required in empirical wavelet transform are strongly dependent on the local maxima of the amplitudes of the Fourier spectrum of a signal, which connotes that Fourier segments are not always reliable and effective if the Fourier spectrum of the signal is complicated and overwhelmed by heavy noises and other strong vibration components. In this paper, sparsity guided empirical wavelet transform is proposed to automatically establish Fourier segments required in empirical wavelet transform for fault diagnosis of rolling element bearings. Industrial bearing fault signals caused by single and multiple railway axle bearing defects are used to verify the effectiveness of the proposed sparsity guided empirical wavelet transform. Results show that the proposed method can automatically discover Fourier segments required in empirical wavelet transform and reveal single and multiple railway axle bearing defects. Besides, some comparisons with three popular signal processing methods including ensemble empirical mode decomposition, the fast kurtogram and the fast spectral correlation are conducted to highlight the superiority of the proposed method.

  14. Intelligent control for braking-induced longitudinal vibration responses of floating-type railway bridges

    International Nuclear Information System (INIS)

    Qu, Wei-Lian; Tu, Jian-Weia; Liu, Jia; Zhou, Qiang; Qin, Shun-Quan; Cheng, Haibin; Pi, Yong-Lin

    2009-01-01

    This paper presents an intelligent control method and its engineering application in the control of braking-induced longitudinal vibration of floating-type railway bridges. Equations of motion for the controlled floating-type railway bridges have been established based on the analysis of the longitudinal vibration responses of floating-type railway bridges to train braking and axle-loads of moving trains. For engineering applications of the developed theory, a full-scale 500 kN smart magnetorheologic (MR) damper has been designed, fabricated and used to carry out experiments on the intelligent control of braking-induced longitudinal vibration. The procedure for using the developed intelligent method in conjunction with the full-scale 500 kN MR dampers has been proposed and used to control the longitudinal vibration responses of the deck of floating-type railway bridges induced by train braking and axle-loads of moving trains. This procedure has been applied to the longitudinal vibration control of the Tian Xingzhou highway and railway cable-stayed bridge over the Yangtze River in China. The simulated results have shown that the intelligent control system using the smart MR dampers can effectively control the longitudinal response of the floating-type railway bridge under excitations of braking and axle-loads of moving trains

  15. Intelligent control for braking-induced longitudinal vibration responses of floating-type railway bridges

    Science.gov (United States)

    Qu, Wei-Lian; Qin, Shun-Quan; Tu, Jian-Weia; Liu, Jia; Zhou, Qiang; Cheng, Haibin; Pi, Yong-Lin

    2009-12-01

    This paper presents an intelligent control method and its engineering application in the control of braking-induced longitudinal vibration of floating-type railway bridges. Equations of motion for the controlled floating-type railway bridges have been established based on the analysis of the longitudinal vibration responses of floating-type railway bridges to train braking and axle-loads of moving trains. For engineering applications of the developed theory, a full-scale 500 kN smart magnetorheologic (MR) damper has been designed, fabricated and used to carry out experiments on the intelligent control of braking-induced longitudinal vibration. The procedure for using the developed intelligent method in conjunction with the full-scale 500 kN MR dampers has been proposed and used to control the longitudinal vibration responses of the deck of floating-type railway bridges induced by train braking and axle-loads of moving trains. This procedure has been applied to the longitudinal vibration control of the Tian Xingzhou highway and railway cable-stayed bridge over the Yangtze River in China. The simulated results have shown that the intelligent control system using the smart MR dampers can effectively control the longitudinal response of the floating-type railway bridge under excitations of braking and axle-loads of moving trains.

  16. Dynamic Investigation of the Hunting Motion of a Railway Bogie in a Curved Track via Bifurcation Analysis

    Directory of Open Access Journals (Sweden)

    Caglar Uyulan

    2017-01-01

    Full Text Available The main purpose of this paper is to analyze and compare the Hopf bifurcation behavior of a two-axle railway bogie and a dual wheelset in the presence of nonlinearities, which are yaw damping forces in the longitudinal suspension system and heuristic creep model of the wheel-rail contact including dead-zone clearance, while running on a curved track. Two-axle railway bogie and dual wheelset were modeled using 12-DOF and 8-DOF system with considering lateral, vertical, roll, and yaw motions. By utilizing Lyapunov’s indirect method, the critical hunting speeds related to these models are evaluated as track radius changes. Hunting defined as the lateral vibration of the wheelset with a large domain was characterized by a limit cycle-type oscillation behavior. Influence of the curved track radius on the lateral displacement of the leading wheelset was also investigated through 2D bifurcation diagram, which is employed in the design of a stable model. Frequency power spectra at critical speeds, which are related to the subcritical and supercritical bifurcations, were represented by comparing the two-axle bogie and dual wheelset model. The evaluated accuracy to predict the critical hunting speed is higher and the hunting frequency in unstable region is lower compared to the dual wheelset model.

  17. Simultaneous Measurements of the Vehicle, Track, and Soil Vibrations at a Surface, Bridge, and Tunnel Railway Line

    Directory of Open Access Journals (Sweden)

    Lutz Auersch

    2017-01-01

    Full Text Available A complex measuring campaign has been performed including the simultaneous measurement of vehicle, track, and soil vibrations during train runs at 16, 25, 40, 63, 80, 100, 125, 140, and 160 km/h and impulse measurements of the passenger car, three track sections, and the soil. A ballast track on the soil surface and on a concrete bridge has been investigated as well as a slab track in a tunnel. The evaluation and comparison of all these data show a generally good agreement for all components if the strong low- and high-frequency cut-off characteristics of the layered and damped soil are incorporated. There is a strong causal correlation between the vehicle and the soil by the dynamic excitation forces and a weak relation between the track and the soil by the axle-sequence spectrum of the train. However, the similarity between the axle-impulse spectrum observed at the track and the spectra of the ground vibration leads to the special excitation component of “scattered axle impulses” which is predominant at the far field points of the soil.

  18. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle

    Science.gov (United States)

    Peng, Jiankun; He, Hongwen; Guo, Hongqiang

    2015-01-01

    This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved. PMID:26236772

  19. Simulating the Effects of Surface Roughness on Reinforced Concrete T Beam Bridge under Single and Multiple Vehicles

    Directory of Open Access Journals (Sweden)

    Rahul Kalyankar

    2016-01-01

    Full Text Available This research focuses on the application of the spatial system of finite element modeling for the vehicle-bridge interaction on reinforced concrete US Girder Bridge in order to obtain the effect of surface roughness. Single vehicle and multiple vehicles on reinforced concrete T beam bridge were studied with variable surface roughness profiles. The effects of six different surface roughness profiles (very good, good, measured, average, poor, and very poor were investigated for vehicle-bridge interaction. The values of the Dynamic Amplification Factor (DAF were obtained for single and multiple vehicles on T Beam Bridge for different surface roughness profiles, along with the distances between the axles of heavy vehicle. It was observed that when the bridge has very good, good, measured, and average surface roughness, the DAF values for the single vehicle over the bridge were observed to be within acceptable limits specified by AASHTO. However, for the bridge with multiple vehicles only very good and measured surface roughness profiles showed a DAF and vehicle axle distances within the acceptable limits. From the current studies, it was observed that the spatial system showed reliable responses for predicting the behavior of the bridge under variable road surface roughness conditions and was reliable in vehicle axle detection, and therefore, it has a potential to be use for realistic simulations.

  20. Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Jiankun Peng

    2015-01-01

    Full Text Available This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control strategies, namely, the interaxle control mode and signal-axle control strategies; the interaxle control strategy generates the ideal braking force distribution in general braking condition, and the single-axle control strategy can ensure braking safety in emergency braking condition; the bottom layer is used to maximize the regenerative braking energy recovery efficiency with a reallocated braking torque strategy; the reallocated braking torque strategy can recovery braking energy as much as possible in the premise of meeting battery charging power. The simulation results show that the proposed hierarchical control strategy is reasonable and can adapt to different typical road surfaces and load cases; the vehicle braking stability and safety can be guaranteed; furthermore, the regenerative braking energy recovery efficiency can be improved.

  1. Changes in inertia and effect on turning effort across different wheelchair configurations.

    Science.gov (United States)

    Caspall, Jayme J; Seligsohn, Erin; Dao, Phuc V; Sprigle, Stephen

    2013-01-01

    When executing turning maneuvers, manual wheelchair users must overcome the rotational inertia of the wheelchair system. Differences in wheelchair rotational inertia can result in increases in torque required to maneuver, resulting in greater propulsion effort and stress on the shoulder joints. The inertias of various configurations of an ultralightweight wheelchair were measured using a rotational inertia-measuring device. Adjustments in axle position, changes in wheel and tire type, and the addition of several accessories had various effects on rotational inertias. The configuration with the highest rotational inertia (solid tires, mag wheels with rearward axle) exceeded the configuration with the lowest (pneumatic tires, spoke wheels with forward axle) by 28%. The greater inertia requires increased torque to accelerate the wheelchair during turning. At a representative maximum acceleration, the reactive torque spanned the range of 11.7 to 15.0 N-m across the wheelchair configurations. At higher accelerations, these torques exceeded that required to overcome caster scrub during turning. These results indicate that a wheelchair's rotational inertia can significantly influence the torque required during turning and that this influence will affect active users who turn at higher speeds. Categorizing wheelchairs using both mass and rotational inertia would better represent differences in effort during wheelchair maneuvers.

  2. Contact-less magneto-elastic torsional sensor based on phase-shift measurements

    International Nuclear Information System (INIS)

    Buchenau, D; Schmidt, G; Eckert, S

    2014-01-01

    We report on the development of a contact-less measurement technique for torsional shear stress τ in ferromagnetic axles or hollow shafts, based on the magneto-elastic effect. In general, two different measuring principles for ferromagnetic materials can be realized, based on: the evaluation of the change of magnetic polarization influenced by shear stress ΔJ(τ) or the change of the magnetic susceptibility Δχ A (τ). The comprehension of the magnetic polarization or the magnetic susceptibility in a sensor concept requires an external magnetic field. Alternating magnetic fields were used as shear stress can disturb not only the amplitude but also the phase distribution of the applied magnetic field. As a result of a torsional moment acting on an axle or hollow shaft, an angle of twist η appears, which is constant over the length of the twisted object. This angle of twist can be understood as a shift of infinitesimal thin cross-sections in which the whole length of the axle is separated. Besides the macroscopic deformation effect, shear forces also affect the Weiss-domains in the micro-scale of the ferromagnetic material. The effects in the micro-scale are the base of the magneto-elastic effect. The combination of the deformation effect in the macro-scale and the deformation of the Weiss-domains in the micro-scale leads to a sophisticated measurement principle for torsional stress in axles or hollow shafts. Magneto-sensitive detectors along or around the measurement object open up the possibility for a contact-less detection of torsional stress in ferromagnetic materials. Besides a strong measuring signal, free from electromagnetic interference, the introduced contact-less measurement principle offers different advantages, like independence from compression strength, nominal tensile stress, impact load, ferromagnetic hysteresis effects and independence of the temperature-dependent electrical conductivity of the axle or hollow shaft. The characteristics of such

  3. SPECIFICITY AND TRENDS IN IMPROVEMENT OF TRACTOR TRAIN BRAKING DYNAMICS

    Directory of Open Access Journals (Sweden)

    G. A. Tayanovsky

    2015-01-01

    Full Text Available The paper considers an important problem in improvement of  braking dynamics potential as part of the overall tractor train dynamics consisting of  an all-wheel drive tractor and heavy-duty trailers which are either locally manufactured or developed with the participation of the paper’s authors. The trailers have a mechanical drive for their wheels from the tractor engine. The trains are intended for transportation peat, organic fertilizers and various loads in  forest exploitation and under other complicated soil and climatic and road conditions where there is justified necessity to activate the trailer wheels.Methodological tools have been developed with the purpose to analyze an influence of the blocked inter-double-reduction axle drive of an active tractor train on distribution of braking forces in double-reduction axles with due account of the heavy-duty peat trailer specificity. Theoretical provisions for wheeled vehicles have been developed with regard to the braking application specificity of active tractor trains with mechanical multi-path drive for wheels of a multi-double-reduction axle propulsion device. The paper presents calculation and theoretical data in order to estimate  distribution of specific braking forces in the double-reduction axle links of the active tractor train when the blocked inter-double-reduction axle drive of the tractor and trailer wheels is switched on and also in the case when the tractor engine is involved in braking process and a clutch coupling is switched-on.Sequence of the calculation formula has been completely carried out in the paper. They represent clear design and operational parameters of the active tractor train. Such approach has made it possible to realize them in the form of a software application which is convenient for analysis of the braking process pertaining to the investigated objects in order to select means for improvement of braking dynamics, rational parameters of multi

  4. Metal-organic and supramolecular architectures based on mechanically interlocked molecules

    Science.gov (United States)

    Fernando, Isurika Rosini

    The focus of this work is on mechanically interlocked molecules (MIMs), which have unusual physicochemical and mechanical properties with potential applications in nano-scale/molecular devices and high strength materials. Rotaxanes, for example, consist of an axle-like molecule threaded through a wheel-like molecule, with bulky groups at the two ends of the axle preventing the wheel from dissociating. The position of the wheel along the axle can be switched in a controllable and reversible manner by applying external stimuli, a feature that might lead to the next generation of computers. Molecularly woven materials (MWMs), another example of molecules with mechanically interlocked features, are predicted to be unprecedentedly strong while being lightweight and flexible. With the ultimate goal of achieving control over the functioning of molecular devices in the solid state, a variety of pseudorotaxane building blocks were prepared and characterized, including a novel, rare blue-colored motif. The temperature-dependent assembly/disassembly of pseudorotaxanes was exploited for the construction of single-wavelength colorimetric temperature sensors over a 100 °C window. Pseudorotaxanes based on aromatic crown ether wheels and disubstituted 4,4'-bipyridinium axles were converted into rotaxanes upon binding to metal complexes (zinc, cadmium, mercury, copper, cobalt), and the formation of ordered crystalline arrays was studied in the solid state. The columnar organization of pseudorotaxanes by Hg2X6 2-- complexes (X = Cl, Br, I), leading to unprecedented dichroic (blue/red) rotaxane crystals, was demonstrated for the first time. From the crystal structures studied it became apparent that negatively charged metal complexes are needed for successful assembly with the positively charged pseudorotaxane units. To be able to use the more common, positively charged metal ions for rotaxane framework construction, neutral and negatively charged pseudorotaxanes were synthesized

  5. Prototype Weigh-In-Motion Performance

    Energy Technology Data Exchange (ETDEWEB)

    Abercrombie, Robert K [ORNL; Beshears, David L [ORNL; Hively, Lee M [ORNL; Scudiere, Matthew B [ORNL; Sheldon, Frederick T [ORNL

    2006-10-01

    Oak Ridge National Laboratory (ORNL) has developed and patented methods to weigh slowly moving vehicles. We have used this technology to produce a portable weigh-in-motion system that is robust and accurate. This report documents the performance of the second-generation portable weigh-in-motion prototype (WIM Gen II). The results of three modes of weight determination are compared in this report: WIM Gen II dynamic mode, WIM Gen II stop-and-go mode, and static (parked) mode on in-ground, static scales. The WIM dynamic mode measures axle weights as the vehicle passes over the system at speeds of 3 to 7 miles per hour (1.3 to 3.1 meters/second). The WIM stop-and-go mode measures the weight of each axle of the vehicle as the axles are successively positioned on a side-by-side pair of WIM measurement pads. In both measurement modes the center of balance (CB) and the total weight are obtained by a straight-forward calculation from axle weights and axle spacings. The performance metric is measurement error (in percent), which is defined as 100 x (sample standard deviation)/(average); see Appendix A for details. We have insufficient data to show that this metric is predictive. This report details the results of weight measurements performed in May 2005 at two sites using different types of vehicles at each site. In addition to the weight measurements, the testing enabled refinements to the test methodology and facilitated an assessment of the influence of vehicle speed on the dynamic-mode measurements. The initial test at the National Transportation Research Center in Knoxville, TN, involved measurements of passenger and light-duty commercial vehicles. A subsequent test at the Arrival/Departure Airfield Control Group (A/DACG) facility in Ft. Bragg, NC, involved military vehicles with gross weights between 3,000 and 75,000 pounds (1,356 to 33,900 kilograms) with a 20,000-pound (9,040 kilograms) limit per axle. For each vehicle, four or more separate measurements were done

  6. Traffic Feasibility Study for a Grade Separator at a Busy Intersection in Vellore

    Science.gov (United States)

    Vasantha Kumar, S.; Gulati, Himanshu; Arora, Shivam

    2017-11-01

    One of the byproduct of urbanization is traffic congestion and before suggesting any solutions to reduce congestion, understanding the present context becomes very important. Study of traffic volumes at busy intersections to find the percentage composition of different vehicle types, directional distribution and peak hour traffic volume is a first step towards understanding the present context of traffic. Hence in the present study, one of the busy intersections in Vellore, namely, Gandhi nagar intersection in Vellore-Katpadi road was selected and traffic flow data was collected using video surveys. It was found that at the selected intersection, the two wheelers and three wheelers alone share 80% of the total traffic when compared to other vehicle types. Nearly 700 trucks and multi axle trailers were observed to pass through the intersection during the analysis period of five hours. That is, on an average 2 trucks/multi axle trailers were passing through the intersection in each minute. As like in other major cities, entry of trucks and other heavy vehicles such as multi axle trailers into the city needs to be banned during peak hours for smooth flow of traffic within city limits. A highest hourly volume of 6939 PCU’s was observed between 4 and 5 pm at the selected intersection. By assuming a 10% uniform traffic growth every year, it was found that after about 4 years, i.e., in 2019, the traffic volume at the intersection may reach 10,000 PCU’s and may warrant for a grade separator or interchange at the intersection.

  7. Contact pressures and the impact of farm equipment on Latosol with the presence and absence of sugarcane straw

    Directory of Open Access Journals (Sweden)

    Reginaldo Barboza da Silva

    2016-06-01

    Full Text Available ABSTRACT High contact pressures applied to soil result in a greater degree of compaction, in addition to promoting other negative effects. The objective of this study was to quantify contact areas by using different methodologies, and pressures of farm equipment employed in production activity and evaluate structural changes caused in a Red Latosol with the presence and absence of straw cover. The design was completely randomized in a factorial scheme of type 4 (tire on front axle, tire on rear axle, tire on a sugarcane wagon and metallic track of sugar cane Harvester x 2 (presence and absence of straw. The contact area (CA of the run was obtained by three procedures: analytical measure of the area of an ellipse (CA1; digital measurement of area of an ellipse (CA2; and measurement of real contact area (RCA, with digital resources. The contact pressure was calculated from the ratio of mass of each machine's axle and the contact area of the run. The contact area obtained according to the procedure of the ellipse (CA1 and CA2 is overrated when compared to actual area obtained digitally (RCA. The straw reduces the contact pressure in the soil, due to the deep tire treads and consequently, increased contact area. Areas where the traffic of the machines occurred with soil covered with the presence of straw showed reduced soil resistance to penetration, cone index and pre-consolidation pressure, confirming that the increased contact area produced by straw reduced the pressure applied and the compression power dissipated in the soil.

  8. Serum sex hormone and growth arrest-specific protein 6 levels in male patients with coronary heart disease

    Directory of Open Access Journals (Sweden)

    Rui Zhao

    2016-01-01

    Full Text Available Epidemiological studies have shown a high prevalence of low serum testosterone levels in men with cardiovascular disease. Moreover, the tyrosine kinase receptor Axl, the ligand of which is growth arrest-specific protein 6 (GAS6, is expressed in the vasculature, and serum GAS6 levels are associated with endothelial dysfunction and cardiovascular events. Testosterone regulates GAS6 gene transcription directly, which inhibits calcification of vascular smooth muscle cells and provides a mechanistic insight into the cardioprotective action of androgens. This study was designed to determine the correlation between serum GAS6 and testosterone levels in male patients with coronary heart disease (CHD. We recruited 225 patients with CHD and 102 apparently healthy controls. Serum concentrations of GAS6 and soluble Axl were quantified by an enzyme-linked immunosorbent assay. Levels of high-sensitivity C-reactive protein, testosterone, estradiol, and other routine biochemical markers were also measured. Testosterone decreased from 432.69 ± 14.40 to 300.76 ± 6.23 ng dl−1 (P < 0.001 and GAS6 decreased from 16.20 ± 0.31 to 12.51 ± 0.19 ng ml−1 (P < 0.001 in patients with CHD, compared with control subjects. Multiple linear regression analysis showed that serum testosterone and GAS6 levels were positively associated in male patients with CHD. Alterations in GAS6 levels may influence the development of CHD. Downregulation of GAS6/Axl signaling in the presence of low sex hormone levels during disease progression is a potential mechanism by which GAS6 affects CHD. This study provides novel results regarding the influence of sex hormones on serum GAS6 levels in patients with CHD.

  9. Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling.

    Science.gov (United States)

    Nelson-Taylor, Sarah K; Le, Anh T; Yoo, Minjae; Schubert, Laura; Mishall, Katie M; Doak, Andrea; Varella-Garcia, Marileila; Tan, Aik-Choon; Doebele, Robert C

    2017-08-01

    Oncogenic rearrangements in RET are present in 1%-2% of lung adenocarcinoma patients. Ponatinib is a multi-kinase inhibitor with low-nanomolar potency against the RET kinase domain. Here, we demonstrate that ponatinib exhibits potent antiproliferative activity in RET fusion-positive LC-2/ad lung adenocarcinoma cells and inhibits phosphorylation of the RET fusion protein and signaling through ERK1/2 and AKT. Using distinct dose escalation strategies, two ponatinib-resistant LC-2/ad cell lines, PR1 and PR2, were derived. PR1 and PR2 cell lines retained expression, but not phosphorylation of the RET fusion and lacked evidence of a resistance mutation in the RET kinase domain. Both resistant lines retained activation of the MAPK pathway. Next-generation RNA sequencing revealed an oncogenic NRAS p.Q61K mutation in the PR1 cell. PR1 cell proliferation was preferentially sensitive to siRNA knockdown of NRAS compared with knockdown of RET, more sensitive to MEK inhibition than the parental line, and NRAS dependence was maintained in the absence of chronic RET inhibition. Expression of NRAS p.Q61K in RET fusion expressing TPC1 cells conferred resistance to ponatinib. PR2 cells exhibited increased expression of EGFR and AXL. EGFR inhibition decreased cell proliferation and phosphorylation of ERK1/2 and AKT in PR2 cells, but not LC-2/ad cells. Although AXL inhibition enhanced PR2 sensitivity to afatinib, it was unable to decrease cell proliferation by itself. Thus, EGFR and AXL cooperatively rescued signaling from RET inhibition in the PR2 cells. Collectively, these findings demonstrate that resistance to ponatinib in RET-rearranged lung adenocarcinoma is mediated by bypass signaling mechanisms that result in restored RAS/MAPK activation. Mol Cancer Ther; 16(8); 1623-33. ©2017 AACR . ©2017 American Association for Cancer Research.

  10. Research on Automotive Dynamic Weighing Method Based on Piezoelectric Sensor

    Directory of Open Access Journals (Sweden)

    Zhang Wei

    2017-01-01

    Full Text Available In order to effectively measure the dynamic axle load of vehicles in motion, the dynamic weighing method of vehicles based on piezoelectric sensor was studied. Firstly, the influencing factors of the measurement accuracy in the dynamic weighing process were analyzed systematically, and the impacts of road irregularities and dynamic weighing system vibration on measurement error were discussed. On the basis of the analysis, the arithmetic mean filter method was used in the software algorithm to filter out the periodic interference added in the sensor signal, the most suitable n value was selected to get the better filtering result by simulation comparison. Then, the dynamic axle load calculation model of high speed vehicles was studied deeply, based on the theoretical response curve of the sensor, the dynamic axle load calculation method based on frequency reconstruction was established according to actual measurement signals of sensors and the analysis from time domain and frequency domain, also the least square method was used to realize the identification of temperature correction coefficient. A large amount of data that covered the usual vehicle weighing range was collected by experiment. The results show that the dynamic weighing signal system identification error all controlled within 10% at the same temperature and 60% of the vehicle data error can be controlled within 7%. The temperature correction coefficient and the correction formula at different temperatures ranges are well adapted to ensure that the vehicle temperature error at different temperatures can also be controlled within 10% and 70% of the vehicle data error within 7%. Furthermore, the weighing results remain stable regardless of the speed of the vehicle which meets the requirements for high-speed dynamic weighing.

  11. Beyond Scheme F

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, C.J.; Fisher, H.; Pepin, J. [Los Alamos National Lab., NM (United States); Gillmann, R. [Federal Highway Administration, Washington, DC (United States)

    1996-07-01

    Traffic classification techniques were evaluated using data from a 1993 investigation of the traffic flow patterns on I-20 in Georgia. First we improved the data by sifting through the data base, checking against the original video for questionable events and removing and/or repairing questionable events. We used this data base to critique the performance quantitatively of a classification method known as Scheme F. As a context for improving the approach, we show in this paper that scheme F can be represented as a McCullogh-Pitts neural network, oar as an equivalent decomposition of the plane. We found that Scheme F, among other things, severely misrepresents the number of vehicles in Class 3 by labeling them as Class 2. After discussing the basic classification problem in terms of what is measured, and what is the desired prediction goal, we set forth desirable characteristics of the classification scheme and describe a recurrent neural network system that partitions the high dimensional space up into bins for each axle separation. the collection of bin numbers, one for each of the axle separations, specifies a region in the axle space called a hyper-bin. All the vehicles counted that have the same set of in numbers are in the same hyper-bin. The probability of the occurrence of a particular class in that hyper- bin is the relative frequency with which that class occurs in that set of bin numbers. This type of algorithm produces classification results that are much more balanced and uniform with respect to Classes 2 and 3 and Class 10. In particular, the cancellation of errors of classification that occurs is for many applications the ideal classification scenario. The neural network results are presented in the form of a primary classification network and a reclassification network, the performance matrices for which are presented.

  12. Bioinformatics analysis to screen the key prognostic genes in ovarian cancer.

    Science.gov (United States)

    Li, Li; Cai, Shengyun; Liu, Shengnan; Feng, Hao; Zhang, Junjie

    2017-04-13

    Ovarian cancer (OC) is a gynecological oncology that has a poor prognosis and high mortality. This study is conducted to identify the key genes implicated in the prognosis of OC by bioinformatic analysis. Gene expression data (including 568 primary OC tissues, 17 recurrent OC tissues, and 8 adjacent normal tissues) and the relevant clinical information of OC patients were downloaded from The Cancer Genome Atlas database. After data preprocessing, cluster analysis was conducted using the ConsensusClusterPlus package in R. Using the limma package in R, differential analysis was performed to identify feature genes. Based on Kaplan-Meier (KM) survival analysis, prognostic seed genes were selected from the feature genes. After key prognostic genes were further screened by cluster analysis and KM survival analysis, they were performed functional enrichment analysis and multivariate survival analysis. Using the survival package in R, cox regression analysis was conducted for the microarray data of GSE17260 to validate the key prognostic genes. A total of 3668 feature genes were obtained, among which 75 genes were identified as prognostic seed genes. Then, 25 key prognostic genes were screened, including AXL, FOS, KLF6, WDR77, DUSP1, GADD45B, and SLIT3. Especially, AXL and SLIT3 were enriched in ovulation cycle. Multivariate survival analysis showed that the key prognostic genes could effectively differentiate the samples and were significantly associated with prognosis. Additionally, GSE17260 confirmed that the key prognostic genes were associated with the prognosis of OC. AXL, FOS, KLF6, WDR77, DUSP1, GADD45B, and SLIT3 might affect the prognosis of OC.

  13. High BIM mRNA levels are associated with longer survival in advanced gastric cancer.

    Science.gov (United States)

    Wu, Nandie; Huang, Ying; Zou, Zhengyun; Gimenez-Capitan, Ana; Yu, Lixia; Hu, Wenjing; Zhu, Lijing; Sun, Xia; Sanchez, Jose Javier; Guan, Wenxian; Liu, Baorui; Rosell, Rafael; Wei, Jia

    2017-03-01

    Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis-relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell death (BIM), astrocyte elevated gene-1 (AEG-1) and AXL receptor tyrosine kinase (AXL) were investigated in 131 advanced GC samples, and the expression levels of these genes were correlated with patients' overall survival (OS). All 131 patients received first-line FOLFOX combination chemotherapy with folinic acid and 5-FU, in which 56 patients were further treated with second-line docetaxel-based chemotherapy. A correlation between the mRNA expression levels of BIM and AEG-1 was observed ( r s =0.30; P=0.002). There was no association between the mRNA expression levels of any of the individual genes analyzed and OS in patients only receiving first-line FOLFOX chemotherapy. In a subgroup of patients receiving docetaxel-based second-line chemotherapy, those with high or intermediate levels of BIM exhibited a median OS of 18.2 months [95% confidence interval (CI), 12.8-23.6], compared with 9.6 months (95% CI, 8.9-10.3) in patients with low BIM levels (P=0.008). However, there was no correlation between the mRNA expression levels of AEG-1 or AXL and OS. The risk of mortality was higher in patients with low BIM mRNA levels than in those with high or intermediate BIM mRNA levels (hazard ratio, 2.61; 95% CI, 1.21-5.62; P=0.010). Therefore, BIM may be considered as a biomarker to identify whether patients could benefit from docetaxel-based second-line chemotherapy in GC.

  14. Evaluation of enrichment by centrifugal separation: the future of the centrifugal-separation method

    International Nuclear Information System (INIS)

    Kanagawa, A.

    A gas centrifuge plant for uranium enrichment is considered from the point of view of economic competition with other methods. Characteristics of the method are presented including: energy efficiency, the cascade, the separation coefficient, the equilibrium separation process, and capability as centrifugal pump. The structure of an individual gas centrifuge separator is described including the rotating cylinder, mechanisms for gas injection and extraction, mechanisms for counter-streaming of gas, the axle holder mechanism, the gas sealing mechanism, and the driving mechanism. (U.S.)

  15. Single-magnet rotary flowmeter for liquid metals

    OpenAIRE

    Priede, Jānis; Buchenau, Dominique; Gerbeth, Gunter

    2010-01-01

    We present a theory of single-magnet flowmeter for liquid metals and compare it with experimental results. The flowmeter consists of a freely rotating permanent magnet, which is magnetized perpendicularly to the axle it is mounted on. When such a magnet is placed close to a tube carrying liquid metal flow, it rotates so that the driving torque due to the eddy currents induced by the flow is balanced by the braking torque induced by the rotation itself. The equilibrium rotation rate, which var...

  16. EXT-II: a second generation advanced ac propulsion system

    Energy Technology Data Exchange (ETDEWEB)

    Bates, B.; Patil, P.B.; Ciccarelli, M.F.

    1986-01-01

    This paper discusses the characteristics of the concept and includes discussion of the system constraints, including traction battery constraints, and brief descriptions of the major subsystems being developed. The components discussed include: the system controller, dc to ac inverter, an internal permanent magnet ac motor and a two-speed automatic transmission with an integral final drive and differential. The motor and transmission are on a common axis and are integrated into one compact unit that is integral with the rear axle of the vehicle.

  17. Heavy Vehicles on Minor Highway Bridges

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Nielsen, Søren R. K.; Enevoldsen, I.

    Vibration of a bridge structure due to the passage of vehicles is an important consideration in the design of bridges. Further, a common problem in bridge engineering practice in these years is the upgrading of minor highway bridges (=5-20 m) to carry heavier loads partly due to a tendency...... of heavier trucks moving at larger speeds, and partly because the authorities want to permit transportation of special heavy goods at a larger part of the road net. These needs will in many cases cause the strengthening of the bridges becomes necessary. In order to keep the expenses of such strengthening....... Each axle is suspended on two elastic supports modelling the wheels....

  18. The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

    Science.gov (United States)

    2016-10-01

    Peter Carmeliet for providing the GAS6−/− mice. The work is dedicated to the memory of Janice E. Berry. conFlIcts oF Interest The authors declare that...Berry JE, Havens A, Pienta KJ, Taichman RS. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Molecular cancer research. 2012...of angiogenesis factor VEGF and homing receptor CXCR4 through hypoxia -inducible factor (HIF)-1a.49 This effect may be via the cyclooxygenase-2 (COX-2

  19. The utilization of coal mining wastes as filling materials in reinforced earth structures. III. Construction of a full scale experimental structure; Utilizacion de los esteriles del carbon como material de relleno en estructuras de tierra reforzada. II. Construccion de una estructura experimental

    Energy Technology Data Exchange (ETDEWEB)

    CaNibano Gonzalez, J.; Martinez, C.; Gonzalez, M.R. [HUNOSA. Programa Desarrollo Esteriles. Oviedo (Spain); Pardo, F.; SopeNa, L. [CEDEX. Laboratorio Geotecnia, Madrid (Spain); Torres, M. [Escuela Tecnica Superior de Ingenieros de Minas, Oviedo (Spain); Perez, J.J. [MOPTMA. Demarcacion Carreteras del Estado, Oviedo (Spain)

    1997-06-01

    This article describes the construction of a full scale experimental structure in which coal mining wastes (mine stones) were utilized as a filling material. In such structure, which was 20 m long and 2 high coal mining wastes from two different tips were tested together with different types of reinforcing frames such as metal bands, geomeshes and Paraweb (Freyssisol) bands. Also, thermocouples were placed at different heights. On the other hand, the said structure was subjected to 3.085 passes of a truck having a ballast of 10.5 tons on its rear axle. The performance of the coal mining wastes was completely satisfactory. (Author) 3 refs.

  20. Unconventional material part FEM analysis

    Directory of Open Access Journals (Sweden)

    Michal TROPP

    2016-12-01

    Full Text Available The article covers the usability of alternative materials in vehicles construction. The paper elaborates upon the setup of the process and analysis of the results of carbon composite component FEM model. The 3D model, used for the examination, is a part of axle from alternative small electric vehicle. The analysis was conducted with the help of MSC Adams and Ansys Workbench software. Color maps of von Mises stress in material and total deformations of the component are the results of calculation.

  1. INFLUENCE OF MOVING LOADS ON CURVED BRIDGES

    OpenAIRE

    Thamer A. Z*, Jabbbar S. A

    2016-01-01

    The behavior of a curved slab bridge decks with uniform thickness under moving load is investigated in this study. Three radii of curvature "R" are used (25, 50 and 75m) along with the straight bridge, R = ∞. The decks are simply supported or clamped along the radial edges and free at the circular edges. The AASHTO[1] standard axle load of the truck H20-44 is used and assumed to move in three track positions on the bridge. The finite element method is employed for the analysis and the ANSYS 5...

  2. Employment of the 307th Medical Battalion (Airborne) in Operations Desert Shield and Desert Storm: A Personal Experience Monograph

    Science.gov (United States)

    1992-05-08

    limited in duration and scope, we didn’t deploy our heavier equipment; X-Ray, Dental , canvas tentage, cots, autoclaves, and miscellaneous support...Oxygen/Fluids Requirements MAJ Clark 16. Medical Supply Stockage 1LT Branch 17. Dental Configuration MAJ Madison 18. Personnel Decontamination SSG...APPARATUS GAS W/ 02 1 0 A6Z252 ANESTESIA SET FIELD: IN CHEST. .. A72260 ANTENNA RC-29- A0712b AXLE CABLE REEL: RL-27 1 0 A79381 ANTENNA GROUP, OE-254 2 1

  3. Simple machines made simple a teacher resource manual

    CERN Document Server

    Andre, Ralph E St

    1993-01-01

    This book allows you to present scientific principles and simple mechanics through hands-on cooperative learning activities. Using inexpensive materials (e.g., tape, paper clips), students build simple machines-such as levers, pulleys, spring scales, gears, wheels and axles, windmills, and wedges-that demonstrate how things work. Activities have easy-to-locate materials lists, time requirements, and step-by-step directions (usually illustrated) on presentation. Ideas for bulletin boards, learning centers, and computer-assisted instruction are an added bonus.

  4. Study on Standard Fatigue Vehicle Load Model

    Science.gov (United States)

    Huang, H. Y.; Zhang, J. P.; Li, Y. H.

    2018-02-01

    Based on the measured data of truck from three artery expressways in Guangdong Province, the statistical analysis of truck weight was conducted according to axle number. The standard fatigue vehicle model applied to industrial areas in the middle and late was obtained, which adopted equivalence damage principle, Miner linear accumulation law, water discharge method and damage ratio theory. Compared with the fatigue vehicle model Specified by the current bridge design code, the proposed model has better applicability. It is of certain reference value for the fatigue design of bridge in China.

  5. Photovoltaic panel clamp

    Science.gov (United States)

    Mittan, Margaret Birmingham [Oakland, CA; Miros, Robert H. J. [Fairfax, CA; Brown, Malcolm P [San Francisco, CA; Stancel, Robert [Loss Altos Hills, CA

    2012-06-05

    A photovoltaic panel clamp includes an upper and lower section. The interface between the assembled clamp halves and the module edge is filled by a flexible gasket material, such as EPDM rubber. The gasket preferably has small, finger like protrusions that allow for easy insertion onto the module edge while being reversed makes it more difficult to remove them from the module once installed. The clamp includes mounting posts or an integral axle to engage a bracket. The clamp also may include a locking tongue to secure the clamp to a bracket.

  6. A STUDY ON THE WHEELSET/SLAB TRACK VERTICAL INTERACTION

    OpenAIRE

    Traian MAZILU

    2012-01-01

    This paper deals with the interaction between a moving wheelset and a slab track due to the short-pitch corrugated rail. The wheelset is modeled using a free-free Timoshenko beam with attached rigid bodies as the axle boxes, wheels and brake discs. The slab track model consists of elastically supported double Euler-Bernoulli beams. In fact, both wheelset and slab track are symmetric structures and the issue of the wheelset/slab track interaction is reduced to the wheel/rail interaction. The n...

  7. Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

    Science.gov (United States)

    2016-09-01

    contains cells that endogenously express MMP-1 and migrate across the wing disc. Trametinib consistently reduced the levels of btl > Ras1,PTENi GFP...Hybridoma Bank catalog no. 3B8D12) and phosphorylated SRC (Invitrogen catalog no. 44660G). Alexa Fluor secondary antibodies were used. Confocal imaging...B.-K., Kozaki, K., Iijima, K., Eto, M., Nakano, T., Akishita, M., and Ouchi, Y. (2007). Gas6/Axl-PI3K/Akt pathway plays a central role in the effect

  8. Detection of generator bearing inner race creep by means of vibration and temperature analysis

    DEFF Research Database (Denmark)

    Skrimpas, Georgios Alexandros; Dragiev, Ivaylo G.; Hilmisson, Reynir

    2015-01-01

    Vibration and temperature analysis are the two dominating condition monitoring techniques applied to fault detection of bearing failures in wind turbine generators. Relative movement between the bearing inner ring and generator axle is one of the most severe failure modes in terms of secondary...... damages and development. Detection of bearing creep can be achieved reliably based on continuous trending of the amplitude of vibration running speed harmonic and temperature absolute values. In order to decrease the number of condition indicators which need to be assessed, it is proposed to exploit...

  9. ABOUT WORKING WITH NARRATIVE TEXTS IN EDUCATIONAL SETTINGS: CONCEPTUAL CLARIFICATIONS AND CREATION OF PRACTICAL EXERCISES FOR CLASSROOM

    Directory of Open Access Journals (Sweden)

    ALEXA TATIANA JIMÉNEZ HEREDIA

    2005-07-01

    Full Text Available The present psychoeducational method is related with the narrative texts use and it is framed in the joint work amongteacher, school psychologist, and pupils. The importance of working with this sort of texts, its relation to educationalproposals made by the Ministry of National Education of Colombia, the criteria for evaluating the psychologicaldevelopment, and the proposal itself are supported. The writing is closed signaling the place of this type of workwithin a more global educational issues, specially, from the research activity of the teacher as a fundamental axle.

  10. Research on Travel Control System of Hydrostatic Transmission Chassis

    Directory of Open Access Journals (Sweden)

    Zhao Liang

    2017-01-01

    Full Text Available Aiming at the control problem of driving system of hydrostatic transmission chassis, the composition of the control system of hydrostatic transmission chassis is introduced and the control method of dual engine is solved. According to the number of driving axles in driving process, The external characteristic curve of the engine controls the variable hydraulic pump by one parameter, controls the rotational speed of the variable hydraulic motor according to the change of the vehicle speed, and introduces the control flow of the brake system. It provides a reference for the design of driving control system of multi-axis hydrostatic transmission chassis.

  11. Estimation et contrôle dynamique longitudinale d’un véhicule électrique avec moteurs-roue

    OpenAIRE

    Geamanu , Marcel-Stefan

    2013-01-01

    The main objective of the present thesis focuses on the integration of the in-wheel electric motors into the conception and control of road vehicles. The present thesis is the subject of the grant 186-654 (2010-2013) between the Laboratory of Signals and Systems (L2S-CNRS) and the French Institute of Petrol and New Energies (IFPEN). The thesis work has originally started from a vehicular electrification project, equipped with in-wheel electric motors at the rear axle, to obtain a full electri...

  12. Indices and Computational Strategy for Unmanned Ground Wheeled Vehicle Mobility Estimation and Enhancement

    Science.gov (United States)

    2013-08-01

    7  Copyright © 2013 by ASME  UNCLASSIFIED  Table 2. DRIVELINE SYSTEMS FOR A 6X6 TERRAIN/OFF-ROAD UGV No. Chassis and Driveline System...Layout No. Chassis and Driveline System Layout 1 Positively locked PDU in transfer case Positively locked inter-axle PDU in tandem 2... Automobile , ONTI, 1935; 3rd edition”, Mashgiz, Moscow. [2] L’vov, 1946, “Theory of Tractor”, Mashgiz, Moscow. [3] Zimelev, G. V., 1957, “Theory of

  13. In-pipe micromachine locomotion via the inertial stepping principle

    Energy Technology Data Exchange (ETDEWEB)

    Yum, Young Jin [University of Ulsan, Ulsan (Korea, Republic of); Hwang, Han Sub [Suweon Science College, Suweon (Korea, Republic of); Kelemen, Michal; Maxim, Vladislav; Frankovsky, Peter [Technical University of Kosice, Kosice (Slovakia)

    2014-08-15

    This paper discusses an in-pipe inspection micromachine intended for locomotion inside a small diameter pipe. The micromachine locomotion is based on the inertial stepping principle, which utilizes the drive force of the two-body impact. The in-pipe micromachine contacts the pipe through the elastic bristles installed on the in-pipe machine and in two lines and crossways with respect to the micromachine axle. The paper describes the principle of locomotion and the dynamics by which the unknown of both the parameters and the relations are experimentally identified. Based on the results, a simulation model was created, and the results of the simulations were compared with experimental results.

  14. ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ УГЛЕРОДИСТЫХ СТАЛЕЙ ДЛЯ ПОДШИПНИКОВ И ШЕСТЕРЕН С УПРОЧНЕНИЕМ УПРАВЛЯЕМОЙ ОБЪЕМНО-ПОВЕРХНОСТНОЙ ЗАКАЛКОЙ С ИНДУКЦИОННОГО НАГРЕВА

    Directory of Open Access Journals (Sweden)

    P. Gurchenko

    2015-01-01

    Full Text Available Experience of the Minsk automobile plant and bearing plant in production, research and test of pilot batches of gear wheels of the drive axle of MAZ trucks and MZSh bearings from U8A steel with hardening by their volume and superficial hardening with application of induction heating and the operated surface hardening cooling is given. Experience of the Minsk automobile plant on introduction in manufacturing application of wheel gears of wheel gearing of MAZ trucks from steel 60PP is considered.

  15. Creation and Reliability Analysis of Vehicle Dynamic Weighing Model

    Directory of Open Access Journals (Sweden)

    Zhi-Ling XU

    2014-08-01

    Full Text Available In this paper, it is modeled by using ADAMS to portable axle load meter of dynamic weighing system, controlling a single variable simulation weighing process, getting the simulation weighing data under the different speed and weight; simultaneously using portable weighing system with the same parameters to achieve the actual measurement, comparative analysis the simulation results under the same conditions, at 30 km/h or less, the simulation value and the measured value do not differ by more than 5 %, it is not only to verify the reliability of dynamic weighing model, but also to create possible for improving algorithm study efficiency by using dynamic weighing model simulation.

  16. Defense Transportation Regulation, Part III: Mobility.

    Science.gov (United States)

    1997-04-11

    but is not limited to, all data associated with a unit equipment list (UEL) or desired equipment list ( DEL ). May include information such as departure...for Dangerous Goods. AC-6 US.DoorffTWm 4OO Svei st SW of Tm ro yon WasnmioE. 0 C 2059O Colonel Dean T. Smith Assistant Deputy Chief of Staff for...weights above each axle. 5ZO000J A0 MASKING TAPE Casa of balane marker d. The following illustrations show examples of methods used to determine weight and

  17. Optimal Design of an Axial-Flux Permanent-Magnet Middle Motor Integrated in a Cycloidal Reducer for a Pedal Electric Cycle

    OpenAIRE

    Yang, Yee-Pien; Jiang, Jia-Ming

    2015-01-01

    This paper proposes an optimal design of a middle motor integrated into a mid-drive unit for pedal electric cycles. This middle motor is an axial-flux permanent magnet brushless DC motor with a stator plate. Facing this plate is a rotor plate that acts as an eccentric component of a cycloidal reducer next to the stator. Both the middle motor and cycloidal reducer are easily installed on the same axle of the bike crankset. In the preliminary design, driving requirements are used to make the mi...

  18. Simple machines

    CERN Document Server

    Graybill, George

    2007-01-01

    Just how simple are simple machines? With our ready-to-use resource, they are simple to teach and easy to learn! Chocked full of information and activities, we begin with a look at force, motion and work, and examples of simple machines in daily life are given. With this background, we move on to different kinds of simple machines including: Levers, Inclined Planes, Wedges, Screws, Pulleys, and Wheels and Axles. An exploration of some compound machines follows, such as the can opener. Our resource is a real time-saver as all the reading passages, student activities are provided. Presented in s

  19. Engine classification using vibrations measured by Laser Doppler Vibrometer on different surfaces

    Science.gov (United States)

    Wei, J.; Liu, Chi-Him; Zhu, Zhigang; Vongsy, Karmon; Mendoza-Schrock, Olga

    2015-05-01

    In our previous studies, vehicle surfaces' vibrations caused by operating engines measured by Laser Doppler Vibrometer (LDV) have been effectively exploited in order to classify vehicles of different types, e.g., vans, 2-door sedans, 4-door sedans, trucks, and buses, as well as different types of engines, such as Inline-four engines, V-6 engines, 1-axle diesel engines, and 2-axle diesel engines. The results are achieved by employing methods based on an array of machine learning classifiers such as AdaBoost, random forests, neural network, and support vector machines. To achieve effective classification performance, we seek to find a more reliable approach to pick authentic vibrations of vehicle engines from a trustworthy surface. Compared with vibrations directly taken from the uncooperative vehicle surfaces that are rigidly connected to the engines, these vibrations are much weaker in magnitudes. In this work we conducted a systematic study on different types of objects. We tested different types of engines ranging from electric shavers, electric fans, and coffee machines among different surfaces such as a white board, cement wall, and steel case to investigate the characteristics of the LDV signals of these surfaces, in both the time and spectral domains. Preliminary results in engine classification using several machine learning algorithms point to the right direction on the choice of type of object surfaces to be planted for LDV measurements.

  20. A Noise-Insensitive Semi-Active Air Suspension for Heavy-Duty Vehicles with an Integrated Fuzzy-Wheelbase Preview Control

    Directory of Open Access Journals (Sweden)

    Zhengchao Xie

    2013-01-01

    Full Text Available Semi-active air suspension is increasingly used on heavy-duty vehicles due to its capabilities of consuming less power and low cost and providing better ride quality. In this study, a new low cost but effective approach, fuzzy-wheelbase preview controller with wavelet denoising filter (FPW, is developed for semi-active air suspension system. A semi-active suspension system with a rolling lobe air spring is firstly modeled and a novel front axle vertical acceleration-based road prediction model is constructed. By adopting a sensor on the front axle, the road prediction model can predict more reliable road information for the rear wheel. After filtering useless signal noise, the proposed FPW can generate a noise-insensitive control damping force. Simulation results show that the ride quality, the road holding, the handling capability, the road friendliness, and the comprehensive performance of the semi-active air suspension with FPW outperform those with the traditional active suspension with PID-wheelbase preview controller (APP. It can also be seen that, with the addition of the wavelet filter, the impact of sensor noise on the suspension performance can be minimized.

  1. UNIFIED VERIFICATION METHOD OF ELECTROMAGNETIC COMPATIBILITY BETWEEN ROLLING STOCK AND TRAIN DETECTION SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Bialon

    2016-06-01

    Full Text Available Purpose. Axle counters are more and more often applied in train detection systems. The wheel sensor is a main part of each axle counter system. In parallel, more and more complex railway vehicles, especially traction ones, are a potential source of interferences influencing the operation of these train detection systems. It is the reason to verify the electromagnetic compatibility (EMC between the signalling equipment, particularly train detection systems and new vehicles in the process of obtaining the permission for their exploitation. The measurement of interfering magnetic fields generated by vehicles is one of tests to be carried out. Methodology. For the simplification and unification purpose of the applied interference test methods the EN 50238 standard and TS 50238-3 technical specification were developed. The specification defines unified testing procedures. However, it is necessary to verify if it may replace different testing methods used in particular European states. It is the goal of the European research project financed from the TEN-T network resources. Findings and originality. This project is part of the larger project of facilitation and speeding up the ERTMS system deployment. One of nine measurement campaigns planned in the frame of this project was conducted in Poland by Railway Research Institute.

  2. Incidence of Trailer Frame Structure on Driver’s Safety during Log Transportation

    Directory of Open Access Journals (Sweden)

    Marco Manzone

    2017-11-01

    Full Text Available The frame structure of the trailer may influence both the traction and the tractor-trailer stability, especially along sloped paths. The aim of this research was to analyze a trailer overturning and the strains on the connected tractors (wheeled, or crawled during log transportation (loose or tied along a hillside. Two two-axle trailers were used: tandem and turntable steering. Three types of measurements were carried out during the field tests: (i the detachment from the ground of the rear upstream wheels (or crawler; (ii the transversal and longitudinal strains occurring when the trailer overturned (and released the hooking system of the tractor; (iii the lateral deviation of the rear wheels (or crawler of the tractor. The study highlighted that the two-axle trailer with turntable steering combined with the crawl tractor gave better results in terms of safety during trailer overturning. In addition, independent of the type of trailer, a tied load was found to be more dangerous than a load restrained only by steel struts, because when overturning, the load forms a single unit with the trailer mass which increases the strains.

  3. A Generalized Mathematical Model for the Fracture Problem of the Suspended Highway

    Directory of Open Access Journals (Sweden)

    Zhao Ying

    2017-01-01

    Full Text Available In order to answer dangling fracture problems of highway, the suspended pavement equivalent for non - suspended pavement, through the special boundary conditions has been suspended highway stress field of expression, in accordance with the 3D fracture model of crack formation, and establish a vacant, a general mathematics model for fracture problems of highway and analysis in highway suspended segment weight and vehicle load limit of highway capacity of Pu For overturning road inPu is less than the force of carrying more than compared to the work and fruit Bridge Hydropower Station Road engineering examples to verify suspended highway should force field expressions for the correctness and applicability. The results show that: when the hanging ratio R 0. 243177 limits of Pu design axle load 100kN. When the vertical crack in the vacant in the direction of length greater than 0. 1, the ultimate bearing capacity is less than the design axle load 100kN; when the hanging ratio R is less than 0. 5, the road to local fracture, the ultimate bearing capacity of suspended stress field expressions in solution; when the hanging ratio is greater than or equal to 0. 5, the road does not reach the limit bearing capacity of the whole body; torque shear surface of the effect is far less than the bending moments on shear planes.

  4. Development of dynamic models of wagons on models 18-9810 and 18-9855 bogies taking into account wheel wear research

    Directory of Open Access Journals (Sweden)

    A. V. Saidova

    2013-04-01

    Full Text Available Purpose. Wear parameters clarification in wear simulation is an actual goal because of absence of corresponding data for freight cars in condition of using them on Russian railways. Research is devoted to development of dynamic models of wagons on three-peace two-axle models 18-9810 and 18-9855 bogies with maximum axle-loads 23,5 ts and 25 ts, and to choice of factors, with varying which parameters in the model of wheel wear can be identified. Methodology. The problem is solved by method of mathematic simulation in «MEDYNA» software. Wear calculation is based on abrasive wear theory (Archard’s theory. Findings. Clarification of wheels’ wear model may be done with varying of friction coefficient between wheel and rail for different wheel profile areas (flange and tread, wear coefficient in Archard’s model for mild and heavy wear and transition between them. Originality. Dynamic models of universal gondola on models 18-9810 and 18-9855 bogies are developed. It is established, that rail treads irregularities size effect wheel wear insignificantly, when car is running on circle track of constant radius. Practical value. Developed dynamic models of wagons on models 18-9810 and 18-9855 bogies may be used in wear simulation, determination of car running characteristics, interaction of car and rail of different type, construction, condition and etc. Research results of some factors influence on freight car wheel wear may be interesting for people, who study this problem.

  5. Verification of residual stresses in flash-butt-weld rails using neutron diffraction

    Science.gov (United States)

    Tawfik, David; Kirstein, Oliver; Mutton, Peter John; Chiu, Wing Kong

    2006-11-01

    Residual stresses developed during flash-butt welding may play a crucial role in prolonging the fatigue life of the welded tracks under service loading conditions. The finished welds typically exhibit high levels of tensile residual stresses in the web region of the weld. Moreover, the surface condition of the web may contain shear drag or other defects resulting from the shearing process which may lead to the initiation and propagation of fatigue cracks in a horizontal split web failure mode under high axle loads. However, a comprehensive understanding into the residual stress behaviour throughout the complex weld geometry remains unclear and is considered necessary to establish the correct localised post-weld heat treatment modifications intended to lower tensile residual stresses. This investigation used the neutron diffraction technique to analyse residual stresses in an AS60 flash-butt-welded rail cooled under normal operating conditions. The findings will ultimately contribute to developing modifications to the flash-butt-welding procedure to lower tensile residual stresses which may then improve rail performance under high axle load.

  6. Scleral ultrastructure and biomechanical changes in rabbits after negative lens application

    Directory of Open Access Journals (Sweden)

    Xiao Lin

    2018-03-01

    Full Text Available AIM: To address the microstructure and biomechanical changes of the sclera of rabbits after negative lens application by spectacle frame apparatus. METHODS: Five New Zealand rabbits of seven weeks post-natal were treated with -8 D lens monocularly over the course of two weeks. Refractive errors and axial length (AXL were measured at the 1st, 7th and 14th days of the induction period. Ultrastructure of sclera was determined with electron microscopy. Biomechanical properties were tested by an Instron 5565 universal testing machine. RESULTS: Lens-induced (LI eyes elongated more rapidly compared with fellow eyes with AXL values of 15.56±0.14 and 15.21±0.14 mm (P<0.01. Fibril diameter was significantly smaller in the LI eyes compared with control ones in the inner, middle, and outer layers (inner layer, 63.533 vs 76.467 nm; middle layer, 92.647 vs 123.984 nm; outer layer, 86.999 vs 134.257 nm, P<0.01, respectively. In comparison with control eyes, macrophage-like cells that engulfed fibroblasts, dilated endoplasmic reticulum, and vacuoles in fibroblasts were observed in the inner and middle stroma in the LI eyes. Ultimate stress and Young’s modulus were lower in the LI eyes compared with those in the control eyes. CONCLUSION: Negative lens application alters eye growth, and results in axial elongation with changes in scleral ultrastructural and mechanical properties.

  7. Design and development of split-parallel through-the road retrofit hybrid electric vehicle with in-wheel motors

    Science.gov (United States)

    Zulkifli, S. A.; Syaifuddin Mohd, M.; Maharun, M.; Bakar, N. S. A.; Idris, S.; Samsudin, S. H.; Firmansyah; Adz, J. J.; Misbahulmunir, M.; Abidin, E. Z. Z.; Syafiq Mohd, M.; Saad, N.; Aziz, A. R. A.

    2015-12-01

    One configuration of the hybrid electric vehicle (HEV) is the split-axle parallel hybrid, in which an internal combustion engine (ICE) and an electric motor provide propulsion power to different axles. A particular sub-type of the split-parallel hybrid does not have the electric motor installed on board the vehicle; instead, two electric motors are placed in the hubs of the non-driven wheels, called ‘hub motor’ or ‘in-wheel motor’ (IWM). Since propulsion power from the ICE and IWM is coupled through the vehicle itself, its wheels and the road on which it moves, this particular configuration is termed ‘through-the-road’ (TTR) hybrid. TTR configuration enables existing ICE-powered vehicles to be retrofitted into an HEV with minimal physical modification. This work describes design of a retrofit- conversion TTR-IWM hybrid vehicle - its sub-systems and development work. Operating modes and power flow of the TTR hybrid, its torque coupling and resultant traction profiles are initially discussed.

  8. Modeling on energy harvesting from a railway system using piezoelectric transducers

    Science.gov (United States)

    Wang, Jianjun; Shi, Zhifei; Xiang, Hongjun; Song, Gangbing

    2015-10-01

    Theoretical models of piezoelectric energy harvesting from railway systems using patch-type and stack-type piezoelectric transducers are studied. An infinite Euler-Bernoulli beam on a Winkler foundation subjected to moving multi-loads is adopted to describe the dynamic behavior of railway track. The voltage and electric power of piezoelectric transducers installed at the bottom of a steel rail are derived analytically. Comparisons with earlier works and experimental results are given, indicating that the present solutions are reliable. Additionally, a parametric study is conducted to discuss the effects of axle loads, running velocity and load resistors on the solutions. The numerical results show that patch-type and stack-type piezoelectric transducers can harvest the available energy from track vibration to supply power for a wireless sensor network node and can also serve as sensors to monitor basic train information, such as the running velocity, the location and the axle load. The present investigations provide a theoretical guide in the design of piezoelectric patch and stack energy harvesters used in railway systems, which can serve as power sources for distributed wireless sensor networks in remote areas. The research results also demonstrate the potential of piezoelectric patches and stack harvesters in designing self-powered wireless sensor networks used in railway systems to ensure train operation safety.

  9. Driver Assistance System for Passive Multi-Trailer Vehicles with Haptic Steering Limitations on the Leading Unit

    Directory of Open Access Journals (Sweden)

    Antonio J. Reina

    2013-04-01

    Full Text Available Driving vehicles with one or more passive trailers has difficulties in both forward and backward motion due to inter-unit collisions, jackknife, and lack of visibility. Consequently, advanced driver assistance systems (ADAS for multi-trailer combinations can be beneficial to accident avoidance as well as to driver comfort. The ADAS proposed in this paper aims to prevent unsafe steering commands by means of a haptic handwheel. Furthermore, when driving in reverse, the steering-wheel and pedals can be used as if the vehicle was driven from the back of the last trailer with visual aid from a rear-view camera. This solution, which can be implemented in drive-by-wire vehicles with hitch angle sensors, profits from two methods previously developed by the authors: safe steering by applying a curvature limitation to the leading unit, and a virtual tractor concept for backward motion that includes the complex case of set-point propagation through on-axle hitches. The paper addresses system requirements and provides implementation details to tele-operate two different off- and on-axle combinations of a tracked mobile robot pulling and pushing two dissimilar trailers.

  10. Driver assistance system for passive multi-trailer vehicles with haptic steering limitations on the leading unit.

    Science.gov (United States)

    Morales, Jesús; Mandow, Anthony; Martínez, Jorge L; Reina, Antonio J; García-Cerezo, Alfonso

    2013-04-03

    Driving vehicles with one or more passive trailers has difficulties in both forward and backward motion due to inter-unit collisions, jackknife, and lack of visibility. Consequently, advanced driver assistance systems (ADAS) for multi-trailer combinations can be beneficial to accident avoidance as well as to driver comfort. The ADAS proposed in this paper aims to prevent unsafe steering commands by means of a haptic handwheel. Furthermore, when driving in reverse, the steering-wheel and pedals can be used as if the vehicle was driven from the back of the last trailer with visual aid from a rear-view camera. This solution, which can be implemented in drive-by-wire vehicles with hitch angle sensors, profits from two methods previously developed by the authors: safe steering by applying a curvature limitation to the leading unit, and a virtual tractor concept for backward motion that includes the complex case of set-point propagation through on-axle hitches. The paper addresses system requirements and provides implementation details to tele-operate two different off- and on-axle combinations of a tracked mobile robot pulling and pushing two dissimilar trailers.

  11. Mixed Skyhook and FxLMS Control of a Half-Car Model with Magnetorheological Dampers

    Directory of Open Access Journals (Sweden)

    Piotr Krauze

    2016-01-01

    Full Text Available The problem of vibration attenuation in a semiactive vehicle suspension is considered. The proposed solution is based on usage of the information about the road roughness coming from the sensor installed on the front axle of the vehicle. It does not need any preview sensor to measure the road roughness as other preview control strategies do. Here, the well-known Skyhook algorithm is used for control of the front magnetorheological (MR damper. This algorithm is tuned to a quarter-car model of the front part of the vehicle. The rear MR damper is controlled by the FxLMS (Filtered-x LMS taking advantage of the information about the motion of the front vehicle axle. The goal of this algorithm is to minimize pitch of the vehicle body. The strategy is applied for a four-degree-of-freedom (4-DOF vehicle model equipped with magnetorheological dampers which were described using the Bouc-Wen model. The suspension model was subjected to the road-induced excitation in the form of a series of bumps within the frequency range 1.0–10 Hz. Different solutions are compared based on the transmissibility function and simulation results show the usefulness of the proposed solution.

  12. The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity.

    Science.gov (United States)

    Filkor, Kata; Németh, Tibor; Nagy, István; Kondorosi, Éva; Urbán, Edit; Kemény, Lajos; Szolnoky, Győző

    2016-08-01

    The systemic host defence mechanisms, especially innate immunity, in venous leg ulcer patients are poorly investigated. The aim of the current study was to measure Candida albicans killing activity and gene expressions of pro- and anti-inflammatory cytokines and innate immune response regulators, TAM receptors and ligands of peripheral blood mononuclear cells separated from 69 venous leg ulcer patients and 42 control probands. Leg ulcer patients were stratified into responder and non-responder groups on the basis of wound healing properties. No statistical differences were found in Candida killing among controls, responders and non-responders. Circulating blood mononuclear cells of patients overexpress pro-inflammatory (IL-1α, TNFα, CXCL-8) and anti-inflammatory (IL-10) cytokines as well as TAM receptors (Tyro, Axl, MerTK) and their ligands Gas6 and Protein S compared with those of control individuals. IL-1α is notably overexpressed in venous leg ulcer treatment non-responders; in contrast, Axl gene expression is robustly stronger among responders. These markers may be considered as candidates for the prediction of treatment response among venous leg ulcer patients. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  13. Structuring of Road Traffic Flows

    Directory of Open Access Journals (Sweden)

    Planko Rožić

    2005-09-01

    Full Text Available Systemic traffic count on the Croatian road network hasbeen carried out for more than three decades in different ways.During this period a large number of automatic traffic countershave been installed, and they operate on different principles.The traffic count has been analyzed from the aspect of vehicleclassification. The count results can be only partly comparedsince they yield different structures of traffic flows. Special analysisrefers to the classification of vehicles by automatic trafficcounters.During the research, a database has been formed with physicalelements of vehicles of over five thousand vehicle types. Theresearch results prove that the vehicle length only is not sufficientfor the classification of vehicles, the way it is used in thepresent automatic traffic counts, but rather the number of axles,the wheelbase as well as the front and rear overhangs needto be considered as well. Therefore, the detector system shouldapply also the detector of axles.The results have been presented that were obtained as partof the program TEST- Technological, research, developmentproject supported by the Minist1y of Science, Education andSport.

  14. System design and energetic characterization of a four-wheel-driven series–parallel hybrid electric powertrain for heavy-duty applications

    International Nuclear Information System (INIS)

    Wang, Enhua; Guo, Di; Yang, Fuyuan

    2015-01-01

    Highlights: • A novel four-wheel-driven series–parallel hybrid powertrain is proposed. • A system model and a rule-based control strategy are designed. • Energetic performance is compared to a rear-wheel-driven hybrid powertrain. • Less torsional oscillation and more robust regenerative braking are achieved. - Abstract: Powertrain topology design is vital for system performance of a hybrid electric vehicle. In this paper, a novel four-wheel-driven series–parallel hybrid electric powertrain is proposed. A motor is connected to the differential of the rear axle. An auxiliary power unit is linked to the differential of the front axle via a clutch. First, a mathematical model was established to evaluate the fuel-saving potential. A rule-based energy management algorithm was subsequently designed, and its working parameters were optimized. The hybrid powertrain system was applied to a transit bus, and the system characteristics were analyzed. Compared to an existing coaxial power-split hybrid powertrain, the fuel economy of the four-wheel-driven series–parallel hybrid powertrain can be at the same level under normal road conditions. However, the proposed four-wheel-driven series–parallel hybrid powertrain can recover braking energy more efficiently under road conditions with a low adhesive coefficient and can alleviate the torsional oscillation occurring at the existing coaxial power-split hybrid powertrain. Therefore, the four-wheel-driven series–parallel hybrid powertrain is a good solution for transit buses toward more robust performance.

  15. Influence of shock absorber condition on pavement fatigue using relative damage concept

    Directory of Open Access Journals (Sweden)

    Pablo Kubo

    2015-12-01

    Full Text Available Considering the importance of the road transportation nowadays, concerns related to pavement deterioration and maintenance have become relevant subjects. Especially for commercial vehicles, the vertical dynamic load (characterized by the tire-road interaction is directly related to wear on the road surface. Given this, the main objective of this paper is to analyse effects of vertical loads applied on the flexible pavement, considering the variation of the condition of shock absorbers from a truck's front suspension. The measurements were performed on a rigid truck, with 2 steering front axles, in a durability test track located in Brazil. With a constant load of 6 tons on the front suspension (the maximum allowed load on front axles according to Brazilian legislation, 3 different shock absorber conditions were evaluated: new, used and failed. By applying the relative damage concept, it is possible to conclude that the variation of the shock absorber conditions will significantly affect the vertical load applied on the pavement. Although the results clearly point to a dependent relationship between the load and the condition of the shock absorbers, it is recommended to repeat the same methodology, in future to analyse the influence of other quarter car model variants (such as spring rate, mass and tire spring stiffness.

  16. Applicability of hydraulic dynamometer for measuring load mass on forwarders

    Directory of Open Access Journals (Sweden)

    Pandur Zdravko

    2015-01-01

    Full Text Available In the last few years, with the start of wood biomass production from wood residues, the need for determining the quantity of extracted wood residuals on a landing site has appeared. The beginning of intensive usage of wood residues for wood biomass starts in lowland forest where all wood residues are extracted with forwarders. There are several ways to determine load mass on a forwarder, first and probably most accurate is the use of load cells which are installed between forwarder undercarriage and loading space. In Croatia, as far as it is known, there is no forwarder with such equipment, although manufacturers offer the installation of such equipment when buying a new forwarder. The second option is using a portable measuring platform (axle scale which was already used for research of axle loads of trucks and forwarders. The data obtained with the measuring platform are very accurate, while its deficiency is relatively great mass, large dimensions and high price. The third option is determining mass by using hydraulic dynamometer which is installed on crane between the rotator and the telescopic boom. The production and installation of such a system is very simple, and with the price it can easily compete with previously described measuring systems. The main deficiency of this system is its unsatisfying accuracy. The results of assortment mass measuring with hydraulic dynamometer installed on a hydraulic crane and discussion on factors influencing obtained results will be presented in this paper.

  17. Use of finite elements analysis for a weigh-in-motion sensor design.

    Science.gov (United States)

    Opitz, Rigobert; Goanta, Viorel; Carlescu, Petru; Barsanescu, Paul-Doru; Taranu, Nicolae; Banu, Oana

    2012-01-01

    High speed weigh-in-motion (WIM) sensors are utilized as components of complex traffic monitoring and measurement systems. They should be able to determine the weights on wheels, axles and vehicle gross weights, and to help the classification of vehicles (depending on the number of axles). WIM sensors must meet the following main requirements: good accuracy, high endurance, low price and easy installation in the road structure. It is not advisable to use cheap materials in constructing these devices for lower prices, since the sensors are normally working in harsh environmental conditions such as temperatures between -40 °C and +70 °C, dust, temporary water immersion, shocks and vibrations. Consequently, less expensive manufacturing technologies are recommended. Because the installation cost in the road structure is high and proportional to the WIM sensor cross section (especially with its thickness), the device needs to be made as flat as possible. The WIM sensor model presented and analyzed in this paper uses a spring element equipped with strain gages. Using Finite Element Analysis (FEA), the authors have attempted to obtain a more sensitive, reliable, lower profile and overall cheaper elastic element for a new WIM sensor.

  18. The analysis of overloaded trucks in indonesia based on weigh in motion data (east of sumatera national road case study

    Directory of Open Access Journals (Sweden)

    Jihanny Jongga

    2018-01-01

    Full Text Available Overloaded trucks phenomena generally common in developing countries where the traffic control is poor. In Indonesia, the percentage of overloaded trucks can reach more than 60% in the total number of trucks and may be one of the substantial factors that reduce the service life of the road pavements. This paper presents the analysis results of the weigh in motion survey data at East of Sumatera National Road (Jalintim in Indonesia and the impact of overloaded trucks on the pavement. For the analysis the simplified approach was used, the axle loads were converted into representative single-axle loads based on 4th power formula by AASHTO 1993 equation. The vehicle damage factor of vehicles is presented and will be compared with the Highways National Standard to estimate the remaining service life of pavement and IRI value prediction. The analysis showed that the vehicle damage factor that determined from weigh in motion data is extremely greater than vehicle damage factor of the national standard in Indonesia which may lead to accelerated deterioration, reducing the service life of the pavement structures and significantly influence the IRI value.

  19. Design and optimization of a flexible arrayed eddy current sensor

    Science.gov (United States)

    Sun, Zhenguo; Cai, Dong; Zou, Cheng; Zhang, Wenzeng; Chen, Qiang

    2017-04-01

    The inspection of the hollow axle inner surfaces is a key process to guarantee the safety of high-speed trains. A novel flexible arrayed eddy current sensor was developed to improve the reliability of the non-destructive testing of the hollow axle inner surfaces, whose main innovative aspect was the new design of excitation/sensing traces to achieve a differential and arrayed configuration. Only two independent excitation traces were used in the sensor to induce eddy currents, which can be detected by 16 differential sensing elements. The lift-off effects and the influence of the excitation frequency and geometrical parameters of the proposed sensor was investigated and presented in this paper. Finite element models were built to analyze the effects of each parameter on the sensor response amplitude. Experimental validations were conducted using a representative set of sensors. Results from experiments and simulations were consistent with each other, which showed that the sensor design can substantially suppress the lift-off effects and modifications of the studied parameters can substantially improve the sensor performance.

  20. Detection of rail corrugation based on fiber laser accelerometers

    International Nuclear Information System (INIS)

    Huang, Wenzhu; Zhang, Wentao; Li, Fang; Du, Yanliang; Sun, Baochen; Ma, Huaixiang

    2013-01-01

    Efficient inspection methods are necessary for detection of rail corrugation to improve the safety and ride quality of railway operations. This paper presents a novel fiber optic technology for detection of rail corrugation based on fiber laser accelerometers (FLAs), tailored to the measurement of surface damage on rail structures. The principle of detection of rail corrugation using double integration of axle-box acceleration is presented. Then we present the theoretical model and test results of FLAs which are installed on the bogie to detect the vertical axle-box acceleration of the train. Characteristics of high sensitivity and large dynamic range are achieved when using fiber optic interferometric demodulation. A flexible inertial algorithm based on double integration and the wavelet denoising method is proposed to accurately estimate the rail corrugation. A field test is carried out on the Datong–Qinhuangdao Railway in north China. The test results are compared with the results of a rail inspection car, which shows that the fiber laser sensing system has a good performance in monitoring rail corrugation. (paper)

  1. Coordination-assembly for quantitative construction of bis-branched molecular shuttles.

    Science.gov (United States)

    Zhu, Liangliang; Lu, Meiqun; Qu, Dahui; Wang, Qiaochun; Tian, He

    2011-06-07

    The development and utilization of a new way to build molecular devices is of importance. To build a novel topology of interlocked molecular systems with a controllable mechanical motion, an axle-like compound comprising azobenzene and alkoxy isophthalate moieties was synthesized first. It would form a switchable hemi-rotaxane structure with α-cyclodextrin (α-CD) ring encapsulated in aqueous solution. Next, the hemi-rotaxane was reacted with ethylene diamine palladium nitrate (Pd(en)(NO(3))(2)) and ethylene diamine platinum nitrate (Pt(en)(NO(3))(2)), respectively, to quantitatively form two bis-branched molecular shuttles in situ. The bis-coordinated Pd(II) complex was formed quickly at room temperature, whereas the bis-coordinated Pt(II) one was effectively treated at 333 K but more stable than the former. In this case, transformation of ring shuttling direction could take place in the stable bis-branched Pt(II) complex. The steric effect of the co-stopper, namely the Pt(II) metal center, made the α-CD ring dynamically shuttle inwards to the alkoxy isophthalate station with the azobenzene's photoisomerization, rather than dethreading from the axle.

  2. Development of Microcontroller-Based Ball and Beam Trainer Kit

    Directory of Open Access Journals (Sweden)

    Gunawan Dewantoro

    2015-03-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE A ball and beam trainer kit based on microcontroller was developed for teaching control system course for the sophomore students. This specially-purposed kit consists of a ball located on a beam with a fixed axle at one of its end. At the other end, a servomotor was employed to control the position of the ball by adjusting the rotation angle of the servomotor. Seven predetermined positions were set to 10, 20, 30, 40, 50, 60, and 70 cm relative to the fixed axle of the beam. The Proportional-Integral-Derivative (PID scheme was then used to compensate the error. This kit is equipped with a user interface to configure controller coefficients, select the set points, plot the actual ball position, and display parameter values. The user interface program runs on PC or notebook connected to microcontroller via serial communications. A questionnaire-based assessment about the use of this kit was conducted by 17 students taking the course, giving a rating value of 94.12%.

  3. Weighing in motion and characterization of the railroad traffic with using the B-WIM technique

    Directory of Open Access Journals (Sweden)

    J. A. DE CARVALHO NETO

    Full Text Available AbstractThe knowledge on the active moving load of a bridge is crucial for the achievement of the information on the behavior of the structure, and thus foresee maintenance, repairs and better definition of the logistics of its active vehicles. This paper presents the development of the algorithms for the application of the Bridge-Weigh In Motion (B-WIM method created by Moses for the weighing of trains during motion and also for the characterization of the rail traffic, allowing the obtainment of information like passage's train velocity and number and spacing of axles, eliminating the dynamic effect. There were implemented algorithms for the determination of the data referring to the geometry of the train and its loads, which were evaluated using a theoretical example, in which it was simulated the passage of the train over a bridge and the loads of its axles were determined with one hundred percent of precision. In addition, it was made a numerical example in finite elements of a reinforced concrete viaduct from the Carajás' Railroad, in which the developed system reached great results on the characterization and weighing of the locomotive when the constitutive equation of the Brazilian Standards was substituted by the one proposed by Collins and Mitchell.

  4. Use of Finite Elements Analysis for a Weigh-in-Motion Sensor Design

    Directory of Open Access Journals (Sweden)

    Viorel Goanta

    2012-05-01

    Full Text Available High speed weigh-in-motion (WIM sensors are utilized as components of complex traffic monitoring and measurement systems. They should be able to determine the weights on wheels, axles and vehicle gross weights, and to help the classification of vehicles (depending on the number of axles. WIM sensors must meet the following main requirements: good accuracy, high endurance, low price and easy installation in the road structure. It is not advisable to use cheap materials in constructing these devices for lower prices, since the sensors are normally working in harsh environmental conditions such as temperatures between –40 °C and +70 °C, dust, temporary water immersion, shocks and vibrations. Consequently, less expensive manufacturing technologies are recommended. Because the installation cost in the road structure is high and proportional to the WIM sensor cross section (especially with its thickness, the device needs to be made as flat as possible. The WIM sensor model presented and analyzed in this paper uses a spring element equipped with strain gages. Using Finite Element Analysis (FEA, the authors have attempted to obtain a more sensitive, reliable, lower profile and overall cheaper elastic element for a new WIM sensor.

  5. Determination of Bruising Damages of Tomato during Road Transportation Process

    Directory of Open Access Journals (Sweden)

    A Mansouri Alam

    2018-03-01

    Full Text Available Introduction The most important post-harvest mechanical damage is bruising. Bruising occurs during the stages of handling, transporting and packaging due to quasi-static and dynamic loads. Vibrations of tomato fruits during transportation by truck will decrease their quality. More than 2.5 million tons damages have been reported during tomato transportation in Iran. Therefore, it is necessary to recognize different parameters of damages during road transportation in order to detect and prevent bruising injury. Materials and Methods In this study, healthy Super Queen verity of tomatoes devoid of any corrosion and mechanical damage multipliers were used. Aaverage of 7 and 5 pieces of fruit in each length and width, respectively in 13*25*37 cm boxes with a capacity of 8 kg were arranged. The boxes were divided into 2 types of truck suspension (model M2631 AIMCO, manufactured in 2010 with air suspension and Nissan trucks 2400, manufactured in 2010 with suspension spring. Boxes were established in three different heights truck, floor truck, height of middle and top of truck, in addition to two different situation boxes on the front axle (S1 and rear axle (S2. In each situation, three levels of height (H1, floor truck, the truck (H2 and the truck (H3 there. The location of each sample inside the fruit boxes bottom row (Loc1 and top (Loc2 boxes marked with marker. In this study, two types of road, highway asphalt and asphalt secondary road was used for transportation. Trucks and vans had the same distance route about 400 km. Fruits were transferred to Hamadan agricultural college. Rheology lab test was a hit with the pendulum. In this study, the amount of energy absorbed from the index (as a parameter to determine the sensitivity and the fruits bruises were used. Hit test was done after transportation of fruits and transferring those to the laboratory in less than 2 hours. Impact energy products were considered higher than the dynamic submission

  6. Indirect Tire Monitoring System - Machine Learning Approach

    Science.gov (United States)

    Svensson, O.; Thelin, S.; Byttner, S.; Fan, Y.

    2017-10-01

    The heavy vehicle industry has today no requirement to provide a tire pressure monitoring system by law. This has created issues surrounding unknown tire pressure and thread depth during active service. There is also no standardization for these kind of systems which means that different manufacturers and third party solutions work after their own principles and it can be hard to know what works for a given vehicle type. The objective is to create an indirect tire monitoring system that can generalize a method that detect both incorrect tire pressure and thread depth for different type of vehicles within a fleet without the need for additional physical sensors or vehicle specific parameters. The existing sensors that are connected communicate through CAN and are interpreted by the Drivec Bridge hardware that exist in the fleet. By using supervised machine learning a classifier was created for each axle where the main focus was the front axle which had the most issues. The classifier will classify the vehicles tires condition and will be implemented in Drivecs cloud service where it will receive its data. The resulting classifier is a random forest implemented in Python. The result from the front axle with a data set consisting of 9767 samples of buses with correct tire condition and 1909 samples of buses with incorrect tire condition it has an accuracy of 90.54% (0.96%). The data sets are created from 34 unique measurements from buses between January and May 2017. This classifier has been exported and is used inside a Node.js module created for Drivecs cloud service which is the result of the whole implementation. The developed solution is called Indirect Tire Monitoring System (ITMS) and is seen as a process. This process will predict bad classes in the cloud which will lead to warnings. The warnings are defined as incidents. They contain only the information needed and the bandwidth of the incidents are also controlled so incidents are created within an

  7. Layout design and energetic analysis of a complex diesel parallel hybrid electric vehicle

    International Nuclear Information System (INIS)

    Finesso, Roberto; Spessa, Ezio; Venditti, Mattia

    2014-01-01

    Highlights: • Layout design, energetic and cost analysis of complex parallel hybrid vehicles. • Development of global and real-time optimizers for control strategy identification. • Rule-based control strategies to minimize fuel consumption and NO x . • Energy share across each working mode for battery and thermal engine. - Abstract: The present paper is focused on the design, optimization and analysis of a complex parallel hybrid electric vehicle, equipped with two electric machines on both the front and rear axles, and on the evaluation of its potential to reduce fuel consumption and NO x emissions over several driving missions. The vehicle has been compared with two conventional parallel hybrid vehicles, equipped with a single electric machine on the front axle or on the rear axle, as well as with a conventional vehicle. All the vehicles have been equipped with compression ignition engines. The optimal layout of each vehicle was identified on the basis of the minimization of the overall powertrain costs during the whole vehicle life. These costs include the initial investment due to the production of the components as well as the operating costs related to fuel consumption and to battery depletion. Identification of the optimal powertrain control strategy, in terms of the management of the power flows of the engine and electric machines, and of gear selection, is necessary in order to be able to fully exploit the potential of the hybrid architecture. To this end, two global optimizers, one of a deterministic nature and another of a stochastic type, and two real-time optimizers have been developed, applied and compared. A new mathematical technique has been developed and applied to the vehicle simulation model in order to decrease the computational time of the optimizers. First, the vehicle model equations were written in order to allow a coarse time grid to be used, then, the control variables (i.e., power flow and gear number) were discretized, and the

  8. Biology of Zika Virus Infection in Human Skin Cells.

    Science.gov (United States)

    Hamel, Rodolphe; Dejarnac, Ophélie; Wichit, Sineewanlaya; Ekchariyawat, Peeraya; Neyret, Aymeric; Luplertlop, Natthanej; Perera-Lecoin, Manuel; Surasombatpattana, Pornapat; Talignani, Loïc; Thomas, Frédéric; Cao-Lormeau, Van-Mai; Choumet, Valérie; Briant, Laurence; Desprès, Philippe; Amara, Ali; Yssel, Hans; Missé, Dorothée

    2015-09-01

    Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that causes a mosquito-borne disease transmitted by the Aedes genus, with recent outbreaks in the South Pacific. Here we examine the importance of human skin in the entry of ZIKV and its contribution to the induction of antiviral immune responses. We show that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZIKV isolate, responsible for the epidemic in French Polynesia. Several entry and/or adhesion factors, including DC-SIGN, AXL, Tyro3, and, to a lesser extent, TIM-1, permitted ZIKV entry, with a major role for the TAM receptor AXL. The ZIKV permissiveness of human skin fibroblasts was confirmed by the use of a neutralizing antibody and specific RNA silencing. ZIKV induced the transcription of Toll-like receptor 3 (TLR3), RIG-I, and MDA5, as well as several interferon-stimulated genes, including OAS2, ISG15, and MX1, characterized by strongly enhanced beta interferon gene expression. ZIKV was found to be sensitive to the antiviral effects of both type I and type II interferons. Finally, infection of skin fibroblasts resulted in the formation of autophagosomes, whose presence was associated with enhanced viral replication, as shown by the use of Torin 1, a chemical inducer of autophagy, and the specific autophagy inhibitor 3-methyladenine. The results presented herein permit us to gain further insight into the biology of ZIKV and to devise strategies aiming to interfere with the pathology caused by this emerging flavivirus. Zika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family. Vector-mediated transmission of ZIKV is initiated when a blood-feeding female Aedes mosquito injects the virus into the skin of its mammalian host, followed by infection of permissive cells via specific receptors. Indeed, skin immune cells, including dermal

  9. Heterogeneity of expression of epithelial-mesenchymal transition (EMT markers in melanocytes and melanoma cell lines

    Directory of Open Access Journals (Sweden)

    Ji Eun eKim

    2013-05-01

    Full Text Available The epithelial-mesenchymal transition (EMT describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterised by a series of coordinated changes including downregulation of the junctional protein E-cadherin (CDH1, up-regulation of transcriptional repressors of E-cadherin such as Snail (SNAI1 and Slug (SNAI2, and up-regulation of N-cadherin. We wished to determine whether cultured normal melanocytes and melanoma cell lines, which are derived from the neural crest, showed signs of a similarly coordinated phenotypic switch. We investigated normal melanocytes and 25 cell lines derived from New Zealand patients with metastatic melanoma. Most lines had been previously genotyped for common mutations such as BRAF, NRAS, PIK3CA, TP53 and CDKN2A. Expression of E-cadherin, N-cadherin, MITF, Snail, Slug, Axl, p53 and Hdm2 was compared by western blotting. Normal melanocytes expressed each of these proteins except for Snail, while normal melanocytes and almost every melanoma line expressed Slug. Expression of individual markers among different melanoma lines varied from high to low or undetectable. Quantitation of western blots showed that expression of MITF-M, the melanocyte-specific isoform of MITF, was positively related to that of E-cadherin but inversely related to that of N-cadherin and Axl. There was also no apparent relationship between expression of any particular marker and the presence of BRAF, NRAS, PIK3CA, TP53 or CDKN2A mutations. The results suggest that melanomas do not show the classical epithelial and mesenchymal phenotypes but rather display either high E-cadherin/high MITF-M expression on one hand, or high N-cadherin/high Axl expression on the other. These may correspond to differentiated and invasive phenotypes in vivo.

  10. OFF-ROAD CAPABILITY IMPROVEMENT OF MAZ-AUTOMOBILE HAVING AGRICULTURAL MODIFICATION

    Directory of Open Access Journals (Sweden)

    A. I. Bobrovnik

    2014-01-01

    Full Text Available The paper contains requirements to parameters of an automobile being designed with axle arrangement 6x4 and technically permissible mass of 25 tons with its all year round operation in agricultural industry with the purpose to ensure in-time load transportation and technological cycle in crop production of the agricultural complex in accordance with time schedule of the executed mechanized works. The future automobile should also have a power takeoff device.The paper presents operation chart flowsheets for cultivation of main crops on mineral and peat soils with indication of automobile motion modes and type of transported loads. Specific properties of peat-bog soils are given in the paper. The paper considers off-road capability of mobile machines when they are moving on soils with low bearing capacity. The paper indicates field applications of automobiles with limited and high off-road capability. Description of wheel interaction with bearing surface area, values of soil resistivity after multiple automobile passages have been given in the paper.The paper specifies values of rolling resistance coefficient and adhesion coefficient of the automobile undercarriage systems in spring and autumn for wheeled and crawler units. Schemes of the automobile front axle drives (electric, hydraulic, mechanical and their characteristics have been analyzed in the paper. An elastic flexible drive with separation of flow power has been proposed for reduction of dynamic loads in a power transmission drive. The paper describes a drive system of auto-analogue steering wheels with hydraulic hydrostatic drive which is located within a front wheel hub that ensure additional thrust. Recommendations for MAZ-automobile modernization with axle arrangement 6x4 have been given with the purpose to improve its off- road capability.Metallic anti-skid chain, segment and small link, track and crawler chains, wideners have obtained a wide application for improvement of automobile

  11. Multipoint targeting of the PI3K/mTOR pathway in mesothelioma

    Science.gov (United States)

    Zhou, S; Liu, L; Li, H; Eilers, G; Kuang, Y; Shi, S; Yan, Z; Li, X; Corson, J M; Meng, F; Zhou, H; Sheng, Q; Fletcher, J A; Ou, W-B

    2014-01-01

    Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of asbestos-associated disease. We previously demonstrated co-activation of multiple receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR), MET, and AXL in mesothelioma cell lines, suggesting that these kinases could serve as novel therapeutic targets. Although clinical trials have not shown activity for EGFR inhibitors in mesothelioma, concurrent inhibition of various activated RTKs has pro-apoptotic and anti-proliferative effects in mesothelioma cell lines. Thus, we hypothesised that a coordinated network of multi-RTK activation contributes to mesothelioma tumorigenesis. Methods: Activation of PI3K/AKT/mTOR, Raf/MAPK, and co-activation of RTKs were evaluated in mesotheliomas. Effects of RTK and downstream inhibitors/shRNAs were assessed by measuring mesothelioma cell viability/growth, apoptosis, activation of signalling intermediates, expression of cell-cycle checkpoints, and cell-cycle alterations. Results: We demonstrate activation of the PI3K/AKT/p70S6K and RAF/MEK/MAPK pathways in mesothelioma, but not in non-neoplastic mesothelial cells. The AKT activation, but not MAPK activation, was dependent on coordinated activation of RTKs EGFR, MET, and AXL. In addition, PI3K/AKT/mTOR pathway inhibition recapitulated the anti-proliferative effects of concurrent inhibition of EGFR, MET, and AXL. Dual targeting of PI3K/mTOR by BEZ235 or a combination of RAD001 and AKT knockdown had a greater effect on mesothelioma proliferation and viability than inhibition of individual activated RTKs or downstream signalling intermediates. Inhibition of PI3K/AKT was also associated with MDM2-p53 cell-cycle regulation. Conclusions: These findings show that PI3K/AKT/mTOR is a crucial survival pathway downstream of multiple activated RTKs in mesothelioma, underscoring that PI3K/mTOR is a compelling target for

  12. Vehicle classes for pavement design and capacity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kubala, J.; Asce, M.; Lalani, N.; O' Connell, R.; Petersen, C.

    1986-11-01

    Transportation engineers working in Colorado were aware of a lack of published data at both the local and national level for vehicle classes on urban streets. Such vehicle class breakdowns are necessary for calculating equivalent daily loaded axle (EDLA) values for pavement design and conducting capacity analyses. A technical committee was formed to collect and analyze weekday vehicle class data on urban streets of various types. The major vehicle classes are passenger cars (70-75%), pickups (15-20%), single unit trucks (5-7%); tractor-trailers, buses, and recreational vehicles account for less than 1%. Using these data, a microcomputer spread sheet was set up to calculate EDLA values for pavement design for a range of design year volumes. This vehicle class data is also very useful in highway capacity calculations.

  13. Effects of subsoil compaction on hydraulic properties and preferential flow in a Swedish clay soil

    DEFF Research Database (Denmark)

    Mossadeghi-Björklund, M; Arvidsson, J.; Keller, Thomas

    2016-01-01

    Soil compaction by vehicular traffic modifies the pore structure and soil hydraulic properties. These changes potentially influence the occurrence of preferential flow, which so far has been little studied. Our aim was to study the effect of compaction on soil hydraulic and transport properties......-by-track with a three-axle dumper with a maximum wheel load of 5.8 Mg. After one year, undisturbed soil columns (20 cm height 20 cm diameter) from both trafficked and control plots at a depth of 30–50 cm were sampled. The columns were analyzed using X-ray CT imaging, together with measures of the degree of preferential...

  14. Energy harvester for rotating environments using offset pendulum and nonlinear dynamics

    International Nuclear Information System (INIS)

    Roundy, Shad; Tola, Jeffry

    2014-01-01

    We present an energy harvester for environments that rotate through the Earth’s gravitational field. Example applications include shafts connected to motors, axles, propellers, fans, and wheels or tires. Our approach uses the unique dynamics of an offset pendulum along with a nonlinear bistable restoring spring to improve the operational bandwidth of the system. Depending on the speed of the rotating environment, the system can act as a bistable oscillator, monostable stiffening oscillator, or linear oscillator. We apply our approach to a tire pressure monitoring system mounted on a car rim. Simulation and experimental test results show that the prototype generator is capable of directly powering an RF transmission every 60 s or less over a speed range of 10 to 155 kph. (paper)

  15. Modeling and analysis of linearized wheel-rail contact dynamics

    International Nuclear Information System (INIS)

    Soomro, Z.

    2014-01-01

    The dynamics of the railway vehicles are nonlinear and depend upon several factors including vehicle speed, normal load and adhesion level. The presence of contaminants on the railway track makes them unpredictable too. Therefore in order to develop an effective control strategy it is important to analyze the effect of each factor on dynamic response thoroughly. In this paper a linearized model of a railway wheel-set is developed and is later analyzed by varying the speed and adhesion level by keeping the normal load constant. A wheel-set is the wheel-axle assembly of a railroad car. Patch contact is the study of the deformation of solids that touch each other at one or more points. (author)

  16. Mathematical model of complex technical asymmetric system based on numerical-analytical boundary elements method

    Directory of Open Access Journals (Sweden)

    Dina V. Lazareva

    2015-06-01

    Full Text Available A new mathematical model of asymmetric support structure frame type is built on the basis of numerical-analytical boundary elements method (BEM. To describe the design scheme used is the graph theory. Building the model taken into account is the effect of frame members restrained torsion, which presence is due to the fact that these elements are thin-walled. The built model represents a real object as a two-axle semi-trailer platform. To implement the BEM algorithm obtained are analytical expressions of the fundamental functions and vector load components. The effected calculations are based on the semi-trailer two different models, using finite elements and boundary elements methods. The analysis showed that the error between the results obtained on the basis of two numerical methods and experimental data is about 4%, that indicates the adequacy of the proposed mathematical model.

  17. EXPERIMENTAL AND ANALYTICAL METHOD FOR ACCELERATED FATIGUE BENCH TEST OF STRUCTURES AT REGULAR MULTI-CYCLE LOADING

    Directory of Open Access Journals (Sweden)

    E. K. Pochtenny

    2006-01-01

    Full Text Available The paper presents main statements of the developed general scientific principles and experimental and analytical method for accelerated bench test of bearing structures and machine parts at a regular loading. According to the test results executed in terms of the proposed methodology it is possible to predict a service life of a number of automotive bearing structures for conditions of irregular loading.The developed method has been used for execution of bench tests and calculation and experimental estimation of a service life of a truck tractor frame, prospective types of axles and elements of trailer train suspension and other bearing structures of automotive machinery of the Minsk Motor-Works.

  18. Acoustics of glass harmonicas

    Science.gov (United States)

    Rossing, Thomas D.

    2004-05-01

    Glass musical instruments are probably as old as glassmaking. At least as early as the 17th century it was discovered that wine glasses, when rubbed with a wet finger, produced a musical tone. A collection of glasses played in this manner is called a glass harp. Another type of glass harmonica, called the armonica by its inventor Benjamin Franklin, employs glass bowls or cups turned by a horizontal axle, so the performer need only touch the rim of the bowls as they rotate to set them into vibration. We discuss the modes of vibration of both types of glass harmonica, and describe the different sounds that are emitted by rubbing, tapping, or bowing them. Rubbing with a wet finger tends to excite only the (2,0) mode and its harmonics through a ``stick-slip'' process, while tapping excites the other modes as well.

  19. New design and the manufacturing techniques of the main friction pair of frictional dampers

    Directory of Open Access Journals (Sweden)

    Aleksander GOLUBENKO

    2007-01-01

    Full Text Available The design of the main friction pair of the frictional oscillations damper of passenger car axle box stage suspension and its manufacturing techniques are described. The difference of the design of the main friction pair consists in replacement of a conicalcontact surface of the shpinton sleeve by a pyramidal surface as well as a cylindrical surface of the frictional slide block by a flat surface of the rectangular form. Technological ways of increase of strength and wear resistance were developed that allowed quantitatively to estimate a reserve of increase of strength and thermal wear resistance by methods of plastic deforming. With the purpose of increase of wear resistance and resource saving the new technology of producing the shpinton sleeve blank is offered by a method of cold die forging, and a frictional slide block – by hot dieforging.

  20. Deformation Properties and Fatigue of Bituminous Mixtures

    Directory of Open Access Journals (Sweden)

    Frantisek Schlosser

    2013-01-01

    Full Text Available Deformation properties and fatigue performance are important characteristics of asphalt bound materials which are used for construction of pavement layers. Viscoelastic asphalt mixtures are better characterized via dynamic tests. This type of tests allows us to collate materials with regard to axle vibrations which lie usually in the range of 6 Hz–25 Hz for standard conditions. Asphalt modified for heat sensitivity in the range from −20°C to +60°C has significant impact on the overall characteristics of the mixture. Deformation properties are used as inputs for empirical mixture design, and fatigue performance of asphalt mixtures reflects the parameters of functional tests. Master curves convey properties of asphalt mixtures for various conditions and allow us to evaluate them without the need of time expensive testing.

  1. Railway Wheel Flat Detection Based on Improved Empirical Mode Decomposition

    Directory of Open Access Journals (Sweden)

    Yifan Li

    2016-01-01

    Full Text Available This study explores the capacity of the improved empirical mode decomposition (EMD in railway wheel flat detection. Aiming at the mode mixing problem of EMD, an EMD energy conservation theory and an intrinsic mode function (IMF superposition theory are presented and derived, respectively. Based on the above two theories, an improved EMD method is further proposed. The advantage of the improved EMD is evaluated by a simulated vibration signal. Then this method is applied to study the axle box vibration response caused by wheel flats, considering the influence of both track irregularity and vehicle running speed on diagnosis results. Finally, the effectiveness of the proposed method is verified by a test rig experiment. Research results demonstrate that the improved EMD can inhibit mode mixing phenomenon and extract the wheel fault characteristic effectively.

  2. Flavivirus Entry Receptors: An Update

    Directory of Open Access Journals (Sweden)

    Manuel Perera-Lecoin

    2013-12-01

    Full Text Available Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell surface and primary receptor(s that bind to virions and direct them to the endocytic pathway. Here, we present the currently available knowledge regarding the flavivirus receptors described so far with specific attention to C-type lectin receptors and the phosphatidylserine receptors, T-cell immunoglobulin and mucin domain (TIM and TYRO3, AXL and MER (TAM. Their role in flavivirus attachment and entry as well as their implication in the virus biology will be discussed in depth.

  3. ac propulsion system for an electric vehicle

    Science.gov (United States)

    Geppert, S.

    1980-01-01

    It is pointed out that dc drives will be the logical choice for current production electric vehicles (EV). However, by the mid-80's, there is a good chance that the price and reliability of suitable high-power semiconductors will allow for a competitive ac system. The driving force behind the ac approach is the induction motor, which has specific advantages relative to a dc shunt or series traction motor. These advantages would be an important factor in the case of a vehicle for which low maintenance characteristics are of primary importance. A description of an EV ac propulsion system is provided, taking into account the logic controller, the inverter, the motor, and a two-speed transmission-differential-axle assembly. The main barrier to the employment of the considered propulsion system in EV is not any technical problem, but inverter transistor cost.

  4. Se projeter, ensemble.

    Directory of Open Access Journals (Sweden)

    Le Comité de Rédaction d' EspacesTemps.net

    2007-11-01

    Full Text Available © Gabriel Orozco, Moon Axle, 2005, acrylic sur toile, Marian Goodman Gallery, New York, droits réservés ( Image commentée par Véronique Mauron, Historienne de l’art. Les membres du Comité de rédaction et certains acteurs discutent très régulièrement du projet intellectuel et scientifique de la revue EspacesTemps. net . Cette question a notamment été débattue lors des différentes Estivales et Automnale de notre revue de 2005 à 2007. Les débats avec les acteurs ont souligné ...

  5. The sophisticated control of the tram bogie on track

    Directory of Open Access Journals (Sweden)

    Radovan DOLECEK

    2015-09-01

    Full Text Available The paper deals with the problems of routing control algorithms of new conception of tram vehicle bogie. The main goal of these research activities is wear reduction of rail wheels and tracks, wear reduction of traction energy losses and increasing of running comfort. The testing experimental tram vehicle with special bogie construction powered by traction battery is utilized for these purposes. This vehicle has a rotary bogie with independent rotating wheels driven by permanent magnets synchronous motors and a solid axle. The wheel forces in bogie are measured by large amounts of the various sensors placed on the testing experimental tram vehicle. Nowadays the designed control algorithms are implemented to the vehicle superset control system. The traction requirements and track characteristics have an effect to these control algorithms. This control including sophisticated routing brings other improvements which is verified and corrected according to individual traction and driving characteristics, and opens new possibilities.

  6. Real-time monitoring of railway infrastructures using fibre Bragg grating sensors

    Science.gov (United States)

    Roveri, N.; Carcaterra, A.; Sestieri, A.

    2015-08-01

    In this work we present the results of a field trial with a FBG sensor array system for the real time monitoring of railway traffic and for the structural health monitoring of both the railway track and train wheels. The test campaign is performed on the 2nd line of Milan metropolitan underground, employing more than 50 FBG sensors along 1.5 km of the rail track, where the trains are tested during daily passenger rail transport, with a roughly maximum speeds of 90 km/h. The measurements were continuatively performed for over 6 months, with a sampling frequency of about 400 Hz. The large amount of data/sensors allows a rather accurate statistical treatment of the measurement data and permits, with dedicated algorithms, the estimation of rail and wheel wear, key traffic parameters such as the number of axles, the train speed and load, and, in the next future, the detection of localized imperfections.

  7. Development of nondestructive system for detecting the cracks in KTX brake disk using Rayleigh wave

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Soo; Lee, Ho Yong [Korea Railroad Research Institute, Uiwang (Korea, Republic of); Yeom, Yun Taek; Park, Jin Hyun; Song, Sung Jing; Kim, Hak Joon [Dept. of Mechanical Engineering, Sungkyunkwan University, Suwon (Korea, Republic of); Kwon, Sung Duck [Dept. of Physics, Andong National University, Andong (Korea, Republic of)

    2017-02-15

    Recently, KTX (Korean Train Express) train stoppage accidents were mainly caused by malfunctioning equipment, aging and cracking of railway vehicles, crack breakages of brake disks, and breakages of brake disks. Breakage of brake disk can cause large-scale casualties such as high-speed collision and concern about derailment by hitting lower axle and wheel. Therefore, in this study, a brake disk with solid and ventilation type, which is the brake disk of a KTX train was modeled, and a dynamometer system was constructed to operate the disk. A Rayleigh wave was used to inspect the surface of the brake disk. An ultrasonic inspection module was developed for the brake disk by using a local immersion method due to the difficulty involved in ultrasonic inspection using an existing immersion method. In addition, the surface defects of the brake disk were evaluated using a dynamometer mock-up system and an ultrasonic inspection module of the brake disk.

  8. Research and industrialization of near-net rolling technology used in shaft parts

    Science.gov (United States)

    Hu, Zhenghuan; Wang, Baoyu; Zheng, Zhenhua

    2018-03-01

    Shaft part rolling is an efficient and green nearnet shaping technology offering many advantages, including high production efficiency, high material utilization rate, high product quality, and excellent production environment. In this paper, the features of shaft part rolling are introduced along with the working principles of two main shaft part rolling technologies, namely, cross wedge rolling (CWR) and skew rolling (SR). In relation to this technology, some R&D achievements gained by the University of Science and Technology Beijing are summarized. Finally, the latest developments in shaft part rolling are presented, including SR steel balls, precise forming of camshaft blank by CWR, SR phosphorous copper balls at room temperature, and CWR hollow axle sleeve. Although the shaft part rolling technology has been widely used in China, it only accounts for about 15% of applicable parts at present. Nevertheless, this technology has broad application prospects.

  9. Energy harvester for rotating environments using offset pendulum and nonlinear dynamics

    Science.gov (United States)

    Roundy, Shad; Tola, Jeffry

    2014-10-01

    We present an energy harvester for environments that rotate through the Earth’s gravitational field. Example applications include shafts connected to motors, axles, propellers, fans, and wheels or tires. Our approach uses the unique dynamics of an offset pendulum along with a nonlinear bistable restoring spring to improve the operational bandwidth of the system. Depending on the speed of the rotating environment, the system can act as a bistable oscillator, monostable stiffening oscillator, or linear oscillator. We apply our approach to a tire pressure monitoring system mounted on a car rim. Simulation and experimental test results show that the prototype generator is capable of directly powering an RF transmission every 60 s or less over a speed range of 10 to 155 kph.

  10. Parameter Design for the Energy Regeneration System of Series Hydraulic Hybrid Bus

    Directory of Open Access Journals (Sweden)

    Song Yunpu

    2014-02-01

    Full Text Available This paper simplifies the energy recovery process in the series hydraulic hybrid bus’ energy regeneration system into a process in which the main axle’s moment of inertia drives the secondary element variable delivery pump/motor and brings hydraulic oil from the oil tank to the accumulator. This process enables braking of the vehicle and also allows recovery of energy to the accumulator. Based on the flow equation for the secondary element variable delivery pump/motor and the torque equilibrium equation for its axle, the force equilibrium equation for vehicle braking and the pressure variation and flow continuity equations for the accumulator, simulation studies are conducted to analyze the effects of various system parameters, such as accumulator capacity, displacement of the secondary element variable delivery pump/motor, initial operating pressure of the system, etc. on system performance during regenerative braking.

  11. Multibody simulations of trolleybus vertical dynamics and influences of spring-damper structural elements

    Directory of Open Access Journals (Sweden)

    Polach P.

    2008-11-01

    Full Text Available Vertical dynamic properties of the ŠKODA 21 Tr low-floor trolleybus were investigated on an artificial test track when driving with a real vehicle and when simulating driving with a multibody model along a virtual test track. Driving along the artificial test track was aimed to determine vertical dynamic properties of the real trolleybus and on the basis of them to verify computer trolleybus models. Time histories and extreme values of the air springs relative deflections are the monitored quantities. Due to differences of the experiments and the computer simulations results the influences of the characteristics of the spring-damper structural elements of the axles suspension and the radial characteristics of the tires used in the trolleybus multibody model on the extreme values of the monitored quantities are evaluated.

  12. Efficiency Improvement through Reduction in Friction and Wear in Powertrain Systems

    Energy Technology Data Exchange (ETDEWEB)

    Michael Killian

    2009-09-30

    The objective of this project is to improve the efficiency of truck drivelines through reduction of friction and parasitic losses in transmission and drive axles. Known efficiencies for these products exceeded 97 percent, so the task was not trivial. The project relied on a working relationship between modeling and hardware testing. Modeling was to shorten the development cycle by guiding the selection of materials, processes and strategies. Bench top and fixture tests were to validate the models. Modeling was performed at a world class, high academic level, but in the end, modeling did not impact the hardware development as much as intended. Insights leading to the most significant accomplishments came from bench top and fixture tests and full scale dynamometer tests. A key development in the project was the formulation of the implementation strategy. Five technical elements with potential to minimize friction and parasitic losses were identified. These elements included churning, lubrication, surface roughness, coatings and textures. An interesting fact is that both Caterpillar and Eaton independently converged on the same set of technical elements in formulating their implementation strategies. Exploiting technical elements of the implementation strategy had a positive impact on transmission and drive axle efficiencies. During one dynamometer test of an Eaton Best Tech 1 transmission, all three gear ranges tested: Under drive, direct drive and over drive, showed efficiencies greater than 99 percent. Technology boosts to efficiency for transmissions reached 1 percent, while efficiency improvements to drive axle pushed 2 percent. These advancements seem small, but the accomplishment is large considering that these products normally run at greater than 97 percent efficiency. Barriers and risks to implementing these technology elements are clear. Schemes using a low fill sump and spray tubes endanger the gears and bearings by lubricant starvation. Gear coatings have

  13. Vehicle Signal Analysis Using Artificial Neural Networks for a Bridge Weigh-in-Motion System

    Directory of Open Access Journals (Sweden)

    Min-Seok Park

    2009-10-01

    Full Text Available This paper describes the procedures for development of signal analysis algorithms using artificial neural networks for Bridge Weigh-in-Motion (B-WIM systems. Through the analysis procedure, the extraction of information concerning heavy traffic vehicles such as weight, speed, and number of axles from the time domain strain data of the B-WIM system was attempted. As one of the several possible pattern recognition techniques, an Artificial Neural Network (ANN was employed since it could effectively include dynamic effects and bridge-vehicle interactions. A number of vehicle traveling experiments with sufficient load cases were executed on two different types of bridges, a simply supported pre-stressed concrete girder bridge and a cable-stayed bridge. Different types of WIM systems such as high-speed WIM or low-speed WIM were also utilized during the experiments for cross-checking and to validate the performance of the developed algorithms.

  14. 3-year follow-up of a long-term registry-based multicentre study on vitamin E diffused polyethylene in total hip replacement

    DEFF Research Database (Denmark)

    Sillesen, Nanna Hylleholt; Greene, Meridith E; Nebergall, Audrey K

    2016-01-01

    PURPOSE: Preclinical studies of vitamin E diffused highly cross-linked polyethylene (E-XLPE) has shown enhanced mechanical properties with less wear. The purpose of our study was to document the early clinical outcome of E-XLPE to ensure, for the safety of patients, that there are no unforeseen...... early adverse events from using this new biomaterial. METHODS: The enrolled patients (n = 977) have received either a porous titanium coated or porous plasma sprayed acetabular shell with either a E-XLPE liner or a medium cross-linked (AXL) liner. At each follow-up 5 patient-reported outcome measures...... hip arthroplasty in functionality and quality of life across the centers. We have not observed any early in vivo adverse effects from diffusing the liners with vitamin E. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00545285....

  15. DETERMINATION OF THE LOADS POSITION ON TRUCKS

    Directory of Open Access Journals (Sweden)

    César A. Chagoyén-Méndez

    2015-07-01

    Full Text Available In this paper, we presented the main problems that entail an inadequate distribution of loads on trucks and we described in detail a methodology for determining the proper position, which concludes with the completion of the installation diagrams. The methodology was obtained from the solution of the particular case of a tank of liquefied petroleum gas (LPG of 14'000 liter on a DAF CF 75.310 truck. Another result of this work is a software which allows to determine the exact position it should be the gravity center of the load relative to the front axle and the reactions on each axis, with the possibility of evaluating different variants.

  16. Characterization of the powertrain components for a hybrid quadricycle

    Science.gov (United States)

    De Santis, M.; Agnelli, S.; Silvestri, L.; Di Ilio, G.; Giannini, O.

    2016-06-01

    This paper presents the experimental characterization of a prototyping hybrid electric quadricycle, which is equipped with two independently actuated hub (in-wheel) motors and powered by a 51 V 132 Ah LiFeYPO4 battery pack. Such a vehicle employs two hub motors located in the rear axles in order to independently drive/brake the rear wheels; such architecture allows to implement a torque vectoring system to improve the vehicle dynamics. Due to its actuation flexibility, energy efficiency and performance potentials, this architecture is one of the promising powertrain design for electric quadricycle. Experimental data obtained from measurements on the vehicle powertrain components going from the battery pack to the inverter and to the in-wheel motor were employed to generate the hub motor torque response and power efficiency maps in both driving and regenerative braking modes. Furthermore, the vehicle is equipped with a gasoline internal combustion engine as range extender whose efficiency was also characterized.

  17. Coal transportation road damage

    International Nuclear Information System (INIS)

    Burtraw, D.; Harrison, K.; Pawlowski, J.A.

    1994-01-01

    Heavy trucks are primarily responsible for pavement damage to the nation's highways. In this paper we evaluate the pavement damage caused by coal trucks. We analyze the chief source of pavement damage (vehicle weight per axle, not total vehicle weight) and the chief cost involved (the periodic overlay that is required when a road's surface becomes worn). This analysis is presented in two stages. In the first section we present a synopsis of current economic theory including simple versions of the formulas that can be: used to calculate costs of pavement wear. In the second section we apply this theory to a specific example proximate to the reference environment for the Fuel Cycle Study in New Mexico in order to provide a numerical measure of the magnitude of the costs

  18. A STUDY ON THE WHEELSET/SLAB TRACK VERTICAL INTERACTION

    Directory of Open Access Journals (Sweden)

    Traian MAZILU

    2012-05-01

    Full Text Available This paper deals with the interaction between a moving wheelset and a slab track due to the short-pitch corrugated rail. The wheelset is modeled using a free-free Timoshenko beam with attached rigid bodies as the axle boxes, wheels and brake discs. The slab track model consists of elastically supported double Euler-Bernoulli beams. In fact, both wheelset and slab track are symmetric structures and the issue of the wheelset/slab track interaction is reduced to the wheel/rail interaction. The nonlinear equations of motion describing the wheelset/slab track interaction due to the short-pitch corrugated rail are solved using the time-domain Green’s functions method and the convolution theorem. The wheelset/slab track interaction due to the short-pitch corrugated rail exhibits a critical velocity when the vibration reaches the maximum level

  19. Savage paves the way

    Energy Technology Data Exchange (ETDEWEB)

    Wolach, D. (Savage Industries Inc., Salt Lake City, UT (United States))

    1994-08-01

    According to the National Coal Association, an average of 105 million tons of coal per year are moved by truck in the USA to their field destination. Hundreds of millions of tons are also moved by truck to preparation plants, rail depots and barge docks for movement beyond. Savage Industries Inc., which describes itself as a leader in the transport of coal by road, moves some 30 million tons per year of coal, lignite, petroleum coke, waste coal and other products, operating in 15 stages. This article briefly describes some recent advances in truck design and discusses weight laws and truck axle configurations which vary greatly across the United States. Coal volumes moved by trucks are likely to increase over the next few years and the article briefly lists some of the new markets for coal transport which may emerge. 1 photo.

  20. Modelling and modal properties of the railway vehicle bogie with two individual wheelset drives

    Directory of Open Access Journals (Sweden)

    Zeman V.

    2007-10-01

    Full Text Available The paper deals with mathematical modelling of vibration and modal analysis of two-axled bogie of a railway vehicle. In comparison with recent publications introducing mathematical models of an individual wheelset drive, this paper is focused on modelling of complex bogie vibration. The bogie frame is linked by primary suspension to the two wheelset drives with hollow shafts and by secondary suspension to the car body. The method is based on the system decomposition into three subsystems – two individual wheelset drives including the mass of the rail and the bogie frame coupled with a half of the car body – and on modelling of couplings among subsystems. The eigenvalues of a linearized autonomous model and stability conditions are investigated in dependence on longitudinal creepage and forward velocity of the railway vehicle. The nonlinear model will be used for investigating the dynamic loading of bogie components caused by different types of excitation.

  1. Movable anode x-ray source with enhanced anode cooling

    Science.gov (United States)

    Bird, C.R.; Rockett, P.D.

    1987-08-04

    An x-ray source is disclosed having a cathode and a disc-shaped anode with a peripheral surface at constant radius from the anode axis opposed to the cathode. The anode has stub axle sections rotatably carried in heat conducting bearing plates which are mounted by thermoelectric coolers to bellows which normally bias the bearing plates to a retracted position spaced from opposing anode side faces. The bellows cooperate with the x-ray source mounting structure for forming closed passages for heat transport fluid. Flow of such fluid under pressure expands the bellows and brings the bearing plates into heat conducting contact with the anode side faces. A worm gear is mounted on a shaft and engages serrations in the anode periphery for rotating the anode when flow of coolant is terminated between x-ray emission events. 5 figs.

  2. Analysis of Powertrain Loading Dynamic Characteristics and the Effects on Fatigue Damage

    Directory of Open Access Journals (Sweden)

    Jinyang Bai

    2017-10-01

    Full Text Available The objective of this study is to investigate the effects of key factors on the powertrain loading dynamic characteristics and fatigue damage. First, the engine and the transmission output shaft torque of a multi-axle vehicle powertrain system were measured by proving grounds (PG testing and analyzed with a conclusion that the powertrain loading changes were mainly related to three key factors: the mean engine torque, the harmonic engine torque, and the vibration properties of the system. Subsequently, a dynamic model considering the three factors was built and validated by the test data. Finally, fatigue damage of shaft parts and gear parts were calculated to investigate the influence degrees of the three factors. The results show that, the harmonic engine torque and the vibration properties of the powertrain system have a great influence on the fatigue damage of shaft parts, and the mean engine torque is the main factor causing the fatigue damage of gear parts.

  3. Hybrid Electric Transit Bus

    Science.gov (United States)

    Viterna, Larry A.

    1997-01-01

    A government, industry, and university cooperative is developing an advanced hybrid electric city transit bus. Goals of this effort include doubling the fuel economy compared to current buses and reducing emissions to one-tenth of current EPA standards. Unique aspects of the vehicle's power system include the use of ultra-capacitors as an energy storage system, and a planned natural gas fueled turbogenerator developed from a small jet engine. Power from both the generator and energy storage system is provided to a variable speed electric motor attached to the rear axle. At over 15000 kg gross weight, this is the largest vehicle of its kind ever built using ultra-capacitor energy storage. This paper describes the overall power system architecture, the evolution of the control strategy, and its performance over industry standard drive cycles.

  4. Research of the Remote Experiment System Based on Virtual Reality

    Science.gov (United States)

    Lei, Liangyu; Liu, Jianjun; Yang, Xiufang

    The remote education based on Virtual Reality technology is one of the leading developmental ways in modern education. The present researching status of VR technology's application in the remote experiment is analyzed and the characteristics are summarized in this paper. Then the remote experiment system is designed and the learning mode of the 3-D virtual experiment, the virtual experiment model based on Internet, the functional modules of virtual experiment system are studied. The network-based system of remote virtual experiment is built with the programming languages VRML and JavaScript. Furthermore, the remote experiment system on fatigue test of the drive axle is developed and some key problems in the remote virtual experiment are realized.

  5. PS main supply: motor-generator set.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    In picture 04 the motor is on the right in the background and the main view is of the generator. The peak power in each PS cycle drawn from the generator, up to 96 MW, is taken from the rotational kinetic energy of the rotor (a heavy-weight of 80 tons), which makes the rotational speed drop by only a few percent. The motor replenishes the average power of 2 to 4 MW. Photo 05: The motor-generator set is serviced every year and, in particular, bearings and slip-rings are carefully checked. To the left is the motor with its slip-rings visible. It has been detached from the axle and moved to the side, so that the rotor can be removed from the huge generator, looming at the right.

  6. Implantation of an ergonomics administration system in a company: report of an occupational therapist specialist in ergonomics.

    Science.gov (United States)

    Moraes, Berla; Andrade, Valéria Sousa

    2012-01-01

    This article aims to describe step-by-step the implementation of an ergonomics administration system in a company from March 2009 till March 2011 by an occupational therapist specialist in ergonomics based on the OSHAS 18001 guidelines and the Regulatory Norms 17 manual. The process began with the definition of five requisites with bases on the manual of application of the Regulatory Norms 17: survey; materials individual transportation and discharge; workplace furniture; workplace equipments; work environment and organization of the work to be managed with bases on the OSHAS 18001 guidelines. The following steps were established: sensitization of the company high administration, elaboration and institution of an ergonomics politics, development of ergonomics committees, ergonomics analysis of the work with recommendation of ergonomic improvements, implantation of improvements and evaluation or the results. This research experiment suggests the importance not only of a guiding axle but also of a professional qualification and participation of the company on the implementation of an ergonomics management system.

  7. Power Tillers for Demining: Blast Test

    Directory of Open Access Journals (Sweden)

    Emanuela Elisa Cepolina

    2007-06-01

    Full Text Available Power tillers are very simple and versatile machines with large scale diffusion in developing countries, where they are commonly used both for agriculture and for transportation purposes. A new integrated participatory approach that makes use of and improves local end-users knowledge has been used to design a new robotic system for humanitarian demining applications in Sri Lanka, using power tiller as core module. A demining machine composed by a tractor unit, a ground processing tool and a vegetation cutting tool is here presented together with results obtained from the first blast test on the preliminary version of tractor unit armouring. Different breakable connections between wheels and axle have been designed to cause physical detachment and interrupt the transmission of the shock wave released by the explosion of a mine under one wheel. Effects of explosions on different types of wheels and on the chassis have been recorded and commented.

  8. Power Tillers for Demining: Blast Test

    Directory of Open Access Journals (Sweden)

    Emanuela Elisa Cepolina

    2008-11-01

    Full Text Available Power tillers are very simple and versatile machines with large scale diffusion in developing countries, where they are commonly used both for agriculture and for transportation purposes. A new integrated participatory approach that makes use of and improves local end-users knowledge has been used to design a new robotic system for humanitarian demining applications in Sri Lanka, using power tiller as core module. A demining machine composed by a tractor unit, a ground processing tool and a vegetation cutting tool is here presented together with results obtained from the first blast test on the preliminary version of tractor unit armouring. Different breakable connections between wheels and axle have been designed to cause physical detachment and interrupt the transmission of the shock wave released by the explosion of a mine under one wheel. Effects of explosions on different types of wheels and on the chassis have been recorded and commented.

  9. Fire protection system management in nuclear facilities: strengthening factor of integrated management system - a case study

    International Nuclear Information System (INIS)

    Santos, Joao Regis dos

    2005-01-01

    The present study investigated and analyzed the importance of a system of integrated safety manage, environment and health in a nuclear installation, having as perspective, the fire protection manage. The inquiry was made using a qualitative research involving a case study, where the considered environment was the Reconversion and UO 2 Plant of the Industrias Nucleares do Brasil (INB), located in Resende, Rio de Janeiro and the studied population, the managers and the staff directly involved with the aspects related to the safety of the industrial complex of the related company. The motivation for the research was the search of a bigger interaction of the questions related to the safety, environment and health in the nuclear industry having, as axle of the investigation, the fire protection. As a result, it was observed that in a nuclear installation, although dealing with diversified safety processes, integration is possible and necessary, since there are more reasons for integration than otherwise. (author)

  10. Structure of a monolayer of molecular rotors on aqueous subphase from grazing-incidence X-ray diffraction.

    Science.gov (United States)

    Kaleta, Jiří; Wen, Jin; Magnera, Thomas F; Dron, Paul I; Zhu, Chenhui; Michl, Josef

    2018-03-23

    In situ grazing-incidence X-ray scattering shows that a monolayer of artificial rod-shaped dipolar molecular rotors produced on the surface of an aqueous subphase in a Langmuir trough has a structure conducive to a 2D ferroelectric phase. The axes of the rotors stand an average of 0.83 nm apart in a triangular grid, perpendicular to the surface within experimental error. They carry 2,3-dichlorophenylene rotators near rod centers, between two decks of interlocked triptycenes installed axially on the rotor axle. The analysis is based first on simultaneous fitting of observed Bragg rods and second on fitting the reflectivity curve with only three adjustable parameters and the calculated rotor electron density, which also revealed the presence of about seven molecules of water near each rotator. Dependent on preparation conditions, a minor and variable amount of a different crystal phase may also be present in the monolayer.

  11. Tracking Control of A Balancing Robot – A Model-Based Approach

    Directory of Open Access Journals (Sweden)

    Zaiczek Tobias

    2014-08-01

    Full Text Available This paper presents a control concept for a single-axle mobile robot moving on the horizontal plane. A mathematical model of the nonholonomic mechanical system is derived using Hamel's equations of motion. Subsequently, a concept for a tracking controller is described in detail. This controller keeps the mobile robot on a given reference trajectory while maintaining it in an upright position. The control objective is reached by a cascade control structure. By an appropriate input transformation, we are able to utilize an input-output linearization of a subsystem. For the remaining dynamics a linear set-point control law is presented. Finally, the performance of the implemented control law is illustrated by simulation results.

  12. Real-time monitoring of railway traffic using fiber Bragg gratings

    Science.gov (United States)

    Filograno, M. L.; Rodriguez-Barrios, A.; Corredera, P.; Martin-Lopez, S.; Rodriguez-Plaza, M.; Andres-Alguacil, A.; Gonzalez-Herraez, M.

    2010-09-01

    In this work we present field tests concerning the application of Fiber Bragg Grating (FBG) sensors for the monitoring of railway traffic. The test campaigns are performed on the Spanish high speed line Madrid-Barcelona, with different types of trains (S-102 TALGO-BOMBARDIER, S-103 SIEMENS-VELARO and S-120 CAF). We located the FBG sensors in the rail track at 70 km from Madrid in the country side, where the trains primarily are tested during commercial operation with maximum speeds between 250-300 km/h. The FBG sensor interrogation system used allows the simultaneous monitoring of four FBG sensors at 8000 samples/s. The different position of the FBG sensors in relation with the rail can be used with different purposes such as train identification, axle counting, speed and acceleration detection, wheel imperfections monitoring and dynamic load calculation.

  13. Experimental Study of the Weptos Wave Energy Converter

    DEFF Research Database (Denmark)

    Pecher, Arthur; Kofoed, Jens Peter; Larsen, Tommy

    2012-01-01

    This paper presents the power performance results of the experimental study of the WEPTOS wave energy converter (WEC). This novel device combines an established and efficient wave energy absorbing mechanism with an adjustable structure that can regulate the amount of incoming wave energy and reduce...... loads in extreme wave conditions. This A-shaped floating structure absorbs the energy in the waves through a multitude of rotors, the shape of which is based on the renowned Salter’s Duck. These rotors pivot around a common axle, one for each leg of the structure, to which the rotors transfer...... the absorbed wave energy and which is connected to a common power take off system (one for each leg). The study investigates the performance of the device in a large range of wave states and estimates the performance in terms of mechanical power available to the power take off system of the WEPTOS WEC for two...

  14. Integration and road tests of a self-sensing CNT concrete pavement system for traffic detection

    Science.gov (United States)

    Han, Baoguo; Zhang, Kun; Burnham, Tom; Kwon, Eil; Yu, Xun

    2013-01-01

    In this paper, a self-sensing carbon nanotube (CNT) concrete pavement system for traffic detection is proposed and tested in a roadway. Pre-cast and cast-in-place self-sensing CNT concrete sensors were simultaneously integrated into a controlled pavement test section at the Minnesota Road Research Facility (MnROAD), USA. Road tests of the system were conducted by using an MnROAD five-axle semi-trailer tractor truck and a van, respectively, both in the winter and summer. Test results show that the proposed self-sensing pavement system can accurately detect the passing of different vehicles under different vehicular speeds and test environments. These findings indicate that the developed self-sensing CNT concrete pavement system can achieve real-time vehicle flow detection with a high detection rate and a low false-alarm rate.

  15. Integration and road tests of a self-sensing CNT concrete pavement system for traffic detection

    International Nuclear Information System (INIS)

    Han, Baoguo; Zhang, Kun; Yu, Xun; Burnham, Tom; Kwon, Eil

    2013-01-01

    In this paper, a self-sensing carbon nanotube (CNT) concrete pavement system for traffic detection is proposed and tested in a roadway. Pre-cast and cast-in-place self-sensing CNT concrete sensors were simultaneously integrated into a controlled pavement test section at the Minnesota Road Research Facility (MnROAD), USA. Road tests of the system were conducted by using an MnROAD five-axle semi-trailer tractor truck and a van, respectively, both in the winter and summer. Test results show that the proposed self-sensing pavement system can accurately detect the passing of different vehicles under different vehicular speeds and test environments. These findings indicate that the developed self-sensing CNT concrete pavement system can achieve real-time vehicle flow detection with a high detection rate and a low false-alarm rate. (paper)

  16. Comparison of Classical and Modern Uncertainty Qualification Methods for the Calculation of Critical Speeds in Railway Vehicle Dynamics

    DEFF Research Database (Denmark)

    Bigoni, Daniele; Engsig-Karup, Allan Peter; True, Hans

    2012-01-01

    This paper describes the results of the application of Uncertainty Quantification methods to a railway vehicle dynamical example. Uncertainty Quantification methods take the probability distribution of the system parameters that stems from the parameter tolerances into account in the result....... In this paper the methods are applied to a lowdimensional vehicle dynamical model composed by a two-axle bogie, which is connected to a car body by a lateral linear spring, a lateral damper and a torsional spring. Their characteristics are not deterministically defined, but they are defined by probability...... distributions. The model - but with deterministically defined parameters - was studied in [1], and this article will focus on the calculation of the critical speed of the model, when the distribution of the parameters is taken into account. Results of the application of the traditional Monte Carlo sampling...

  17. Intersectional Dialogue - A Cosmopolitical Dialogue of Ethics

    Directory of Open Access Journals (Sweden)

    Rebecca Adami

    2013-08-01

    Full Text Available The article is based on a critical cosmopolitan outlook on dialogue as not aimed at reaching consensus, but rather keeping dialogue of difference open, with the ability to reach common understanding of human rights on conflicting grounds. Intersectional dialogue is used as a concept that opens up possibilities to study, in a pragmatic sense, the ‘cosmopolitan space’ in which different axles of power met in the historical drafting of human rights. By enacting analysis of United Nations (UN documents from 1948 on the process of drafting the Universal Declaration on Human Rights (UDHR the conceptualization of intersectional dialogue is put to work. The utopian foundation for deliberative democracy as dialogue in the absence of power and interest does not acknowledge the reality in which the human rights were negotiated and debated. The paper questions the dominant narrative of a western philosophical ground for the universality of human rights.

  18. INTOXICAÇÃO EXPERIMENTAL POR Kalanchoe Blossfeldiana (CRASSULACEAE EM CÃES

    Directory of Open Access Journals (Sweden)

    Leandro Bertoni Cavalcanti Teixeira

    2010-12-01

    Full Text Available The purpose of this study was to evaluate the clinical and laboratorial aspects of the oral administration of Kalanchoe blossfeldiana in dogs. Twelve dogs, from two to five years of age, without breed or sex preferences, were used. The animals were inoculated with the K. blossfeldiana extract and monitored by complete blood count (CBC, serum biochemical analysis of creatinokinase (CK, alanine aminotransferase (ALT, alkaline phosfatase (FA and electrocardiographic exam for any cardio-toxic effect from the extract. No significant changes were identified by clinical examination, CBC, blood chemistry or EKG exams, with all results within standard values. The electrocardiographic exam of all the animals presented normal rhythm (sinus arrhythmia, cardiac axle and wave measures, without necrose or cardiac ischemia indication. These results suggested that K. blossfeldiana extract do not cause acute intoxication in dogs within the scope of this experiment.

  19. Fire protection system management in nuclear facilities: strengthening factor of integrated management system - a case study; Gestao de sistema de protecao contra incendio em instalacoes nucleares: fator de fortalecimento do sistema de gestao integrada - um estudo de caso

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Joao Regis dos

    2005-07-01

    The present study investigated and analyzed the importance of a system of integrated safety manage, environment and health in a nuclear installation, having as perspective, the fire protection manage. The inquiry was made using a qualitative research involving a case study, where the considered environment was the Reconversion and UO{sub 2} Plant of the Industrias Nucleares do Brasil (INB), located in Resende, Rio de Janeiro and the studied population, the managers and the staff directly involved with the aspects related to the safety of the industrial complex of the related company. The motivation for the research was the search of a bigger interaction of the questions related to the safety, environment and health in the nuclear industry having, as axle of the investigation, the fire protection. As a result, it was observed that in a nuclear installation, although dealing with diversified safety processes, integration is possible and necessary, since there are more reasons for integration than otherwise. (author)

  20. Experimental analysis of wheel noise emission as a function of the contact point location

    Science.gov (United States)

    Bracciali, A.; Piccioli, F.

    2003-10-01

    Recent analyses show that the wheel noise emission depends on the lateral position of the contact patch area on the wheel tyre. This displacement from the nominal position is such that different wheel modes are excited, resulting in a different frequency and amplitude composition of the wheel related noise component. In this paper the results of a test programme held on the ETR500 Italian high-speed train are shown. Thanks to a special device mounted under the axle box comprising a microphone and a windshield, it has been possible to measure the wheel noise continuously up to 300 km/h in tangent track and in curves. The behaviour of wheels in different condition of line curvature is shown, together with the results from a new type of constrained layer damped wheel.

  1. Phase transformations of under-cooled austenite of new bainitic materials for scissors crossovers

    Directory of Open Access Journals (Sweden)

    J. Pacyna

    2008-07-01

    Full Text Available The paper contains CCT diagrams presenting a transformation kinetics of under-cooled austenite from two new bainitic cast steels which the scissors crossovers for heavy-duty railway tracks (min. 230kN/axle at the speed up to 200 km/h are made of. The cooling ranges of UIC60 type railway tracks plot on the CCT diagrams indicate that there is a 100% bainitic structure in the scissors crossovers made of these cast steels as well, but mainly it would be a favourable for cracking resistance lower bainite. The achievable hardness of scissors crossovers made of new materials make it possible to use high–temperature tempering resulting in obtaining of good crack resistance. However one should provide a good quality of castings made.

  2. Damage identification of supporting structures with a moving sensory system

    Science.gov (United States)

    Zhu, X. Q.; Law, S. S.; Huang, L.; Zhu, S. Y.

    2018-02-01

    An innovative approach to identify local anomalies in a structural beam bridge with an instrumented vehicle moving as a sensory system across the bridge. Accelerations at both the axle and vehicle body are measured from which vehicle-bridge interaction force on the structure is determined. Local anomalies of the structure are estimated from this interaction force with the Newton's iterative method basing on the homotopy continuation method. Numerical results with the vehicle moving over simply supported or continuous beams show that the acceleration responses from the vehicle or the bridge structure are less sensitive to the local damages than the interaction force between the wheel and the structure. Effects of different movement patterns and moving speed of the vehicle are investigated, and the effect of measurement noise on the identified results is discussed. A heavier or slower vehicle has been shown to be less sensitive to measurement noise giving more accurate results.

  3. Training Extract, AFSC 431X1. Tactical Aircraft Maintenance.

    Science.gov (United States)

    1982-01-01

    W 13 "I Iaip ft IN V o w, 0 . wI --. Milk w ow 0 k& - do ’ 4 I b. A I - x.i ,q I 4A V- !q o IA a4 $-* 9 I:I IU aw We 4 13. 0." wsi Go S" 4’i ax~l ad...U& 3 v zI I- ?A6 1) m M w I "a-a 44 dig P 4 4 L S ~~ sib.J~l f1 4 I0 9~i~ .3 - Uht ~I 4 ;A i 4 r 4w 04 beaslAi U# hi wag wO w wt!a N a I-She6P 5C.4 0

  4. MCF-10A-NeoST: A New Cell System for Studying Cell-ECM and Cell-Cell Interactions in Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zantek, Nicole Dodge; Walker-Daniels, Jennifer; Stewart, Jane; Hansen, Rhonda K.; Robinson, Daniel; Miao, Hui; Wang, Bingcheng; Kung, Hsing-Jien; Bissell, Mina J.; Kinch, Michael S.

    2001-08-22

    There is a continuing need for genetically matched cell systems to model cellular behaviors that are frequently observed in aggressive breast cancers. We report here the isolation and initial characterization of a spontaneously arising variant of MCF-10A cells, NeoST, which provides a new model to study cell adhesion and signal transduction in breast cancer. NeoST cells recapitulate important biological and biochemical features of metastatic breast cancer, including anchorage-independent growth, invasiveness in threedimensional reconstituted membranes, loss of E-cadherin expression, and increased tyrosine kinase activity. A comprehensive analysis of tyrosine kinase expression revealed overexpression or functional activation of the Axl, FAK, and EphA2 tyrosine kinases in transformed MCF-10A cells. MCF-10A and these new derivatives provide a genetically matched model to study defects in cell adhesion and signaling that are relevant to cellular behaviors that often typify aggressive breast cancer cells.

  5. Optimal design of high-speed loading spindle based on ABAQUS

    Science.gov (United States)

    Yang, Xudong; Dong, Yu; Ge, Qingkuan; Yang, Hai

    2017-12-01

    The three-dimensional model of high-speed loading spindle is established by using ABAQUS’s modeling module. A finite element analysis model of high-speed loading spindle was established by using spring element to simulate bearing boundary condition. The static and dynamic performance of the spindle structure with different specifications of the rectangular spline and the different diameter neck of axle are studied in depth, and the influence of different spindle span on the static and dynamic performance of the high-speed loading spindle is studied. Finally, the optimal structure of the high-speed loading spindle is obtained. The results provide a theoretical basis for improving the overall performance of the test-bed

  6. Hydraulic turbines

    International Nuclear Information System (INIS)

    Meluk O, G.

    1998-01-01

    The hydraulic turbines are defined according to the specific speed, in impulse turbines and in reaction turbines. Currently, the Pelton turbines (of impulse) and the Francis and Kaplan turbines (of reaction), they are the most important machines in the hydroelectric generation. The hydraulic turbines are capable of generating in short times, large powers, from its loads zero until the total load and reject the load instantly without producing damages in the operation. When the hydraulic resources are important, the hydraulic turbines are converted in the axle of the electric system. Its combination with thermoelectric generation systems, it allow the continuing supply of the variations in demand of energy system. The available hydraulic resource in Colombia is of 93085 MW, of which solely 9% is exploited, become 79% of all the electrical country generation, 21% remaining is provided by means of the thermoelectric generation

  7. Identification of New Biomarkers Associated With IDH Mutation and Prognosis in Astrocytic Tumors Using NanoString nCounter Analysis System.

    Science.gov (United States)

    Zhang, Ming; Pan, Yi; Qi, Xueling; Liu, Yan; Dong, Rongfang; Zheng, Danfeng; Chang, Qing; Zhang, Jing; Fang, Weigang; Zhong, Yanfeng

    2018-02-01

    Isocitrate dehydrogenase (IDH) mutations have been reported as biomarkers associated with tumorigenesis and prognosis in gliomas. However, genes affected by these mutations are still under investigation. The purpose of this study is to identify new molecular biomarkers associated with IDH mutation and prognosis in astrocytic tumors, which account for the largest proportion of gliomas. NanoString analysis was conducted on 40 astrocytic tumors. In total, 69 genes and 6 fusion genes were selected for screening. Quantitative real-time polymerase chain reaction and immunohistochemistry were used to validate the selected discriminatory genes. Kaplan-Meier survival curves and log-rank test were used to analyze the overall survival and progression-free survival. mRNA levels of NTRK3, ERCC1, JAK2, AXL, BCL2, ESR1, HSP90AB1, TUBB3, RET, and ABCG2 were elevated in the IDH mutant group, whereas levels of POSTN and ERBB2 were elevated in the IDH wild-type group. Genes more highly expressed in the better prognosis group included NTRK3, ERCC1, ROS1, ERBB4, BCL2, CDKN2A, AXL, PI3KCA, HSP90AB1, ABCG2, JAK2, and RET. In the worse prognosis group, TIMP1, POSTN, and ERBB2 showed increased expressions. The elevated expression of HSP90AB1 was correlated with IDH mutation, long survival, and secondary glioblastomas. Elevated TIMP1 expression was related to high tumor grade and short patient survival. The results of NanoString were confirmed with quantitative real-time polymerase chain reaction and immunohistochemistry. HSP90AB1 is related to IDH mutation and the expressions of HSP90AB1 and TIMP1 can predict prognosis in astrocytic tumors. The NanoString analysis system is a precise and reliable method to detect mRNA expression in formalin-fixed paraffin-embedded samples.

  8. Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity*

    Science.gov (United States)

    Nguyen, Khanh-Quynh N.; Tsou, Wen-I; Calarese, Daniel A.; Kimani, Stanley G.; Singh, Sukhwinder; Hsieh, Shelly; Liu, Yongzhang; Lu, Bin; Wu, Yi; Garforth, Scott J.; Almo, Steve C.; Kotenko, Sergei V.; Birge, Raymond B.

    2014-01-01

    MERTK, a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases, has complex and diverse roles in cell biology. On the one hand, knock-out of MERTK results in age-dependent autoimmunity characterized by failure of apoptotic cell clearance, while on the other, MERTK overexpression in cancer drives classical oncogene pathways leading to cell transformation. To better understand the interplay between cell transformation and efferocytosis, we stably expressed MERTK in human MCF10A cells, a non-tumorigenic breast epithelial cell line devoid of endogenous MERTK. While stable expression of MERTK in MCF10A resulted in enhanced motility and AKT-mediated chemoprotection, MERTK-10A cells did not form stable colonies in soft agar, or enhance proliferation compared with parental MCF10A cells. Concomitant to chemoresistance, MERTK also stimulated efferocytosis in a gain-of-function capacity. However, unlike AXL, MERTK activation was highly dependent on apoptotic cells, suggesting MERTK may preferentially interface with phosphatidylserine. Consistent with this idea, knockdown of MERTK in breast cancer cells MDA-MB 231 reduced efferocytosis, while transient or stable expression of MERTK stimulated apoptotic cell clearance in all cell lines tested. Moreover, human breast cancer cells with higher endogenous MERTK showed higher levels of efferocytosis that could be blocked by soluble TAM receptors. Finally, through MERTK, apoptotic cells induced PD-L1 expression, an immune checkpoint blockade, suggesting that cancer cells may adopt MERTK-driven efferocytosis as an immune suppression mechanism for their advantage. These data collectively identify MERTK as a significant link between cancer progression and efferocytosis, and a potentially unrealized tumor-promoting event when MERTK is overexpressed in epithelial cells. PMID:25074939

  9. Optical Defocus Rapidly Changes Choroidal Thickness in Schoolchildren.

    Directory of Open Access Journals (Sweden)

    Danyang Wang

    Full Text Available The current study aimed to examine the short-term choroidal response to optical defocus in schoolchildren. Myopic schoolchildren aged 8-16 were randomly allocated to control group (CG, myopic defocus group (MDG and hyperopic defocus group (HDG (n = 17 per group. Children in MDG and HDG received additional +3D and -3D lenses, respectively, to their full corrections on the right eyes. Full correction was given to their left eyes, and on both eyes in the CG. Axial length (AXL and subfoveal choroidal thickness (SFChT were then measured by spectral domain optical coherence tomography. Children wore their group-specific correction for 2 hours after which any existing optical defocus was removed, and subjects wore full corrections for another 2 hours. Both the AXL and SFChT were recorded hourly for 4 hours. The mean refraction of all subjects was -3.41 ± 0.37D (± SEM. SFChT thinned when exposed to hyperopic defocus for 2 hours but less thinning was observed in response to myopic defocus compared to the control group (p < 0.05, two-way ANOVA. Removal of optical defocus significantly decreased SFChT in the MDG and significantly increased SFChT in the HDG after 1 and 2 hours (mean percentage change at 2-hour; control vs. hyperopic defocus vs. myopic defocus; -0.33 ± 0.59% vs. 3.04 ± 0.60% vs. -1.34 ± 0.74%, p < 0.01. Our results showed short-term exposure to myopic defocus induced relative choroidal thickening while hyperopic defocus led to choroidal thinning in children. This rapid and reversible choroidal response may be an important clinical parameter in gauging retinal response to optical defocus in human myopia.

  10. Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy.

    Science.gov (United States)

    Pelizzaro-Rocha, Karin Juliane; de Jesus, Marcelo Bispo; Ruela-de-Sousa, Roberta Regina; Nakamura, Celso Vataru; Reis, Fabiano Souza; de Fátima, Angelo; Ferreira-Halder, Carmen Veríssima

    2013-12-01

    Pancreatic cancer ranks fourth among cancer-related causes of death in North America. Minimal progress has been made in the diagnosis and treatment of patients with late-stage tumors. Moreover, pancreatic cancer aggressiveness is closely related to high levels of pro-survival mediators, which can ultimately lead to rapid disease progression, resistance and metastasis. The main goal of this study was to define the mechanisms by which calix[6]arene, but not other calixarenes, efficiently decreases the aggressiveness of a drug resistant human pancreas carcinoma cell line (Panc-1). Calix[6]arene was more potent in reducing Panc-1 cell viability than gemcitabine and 5-fluorouracil. In relation to the underlying mechanisms of cytotoxic effects, it led to cell cycle arrest in the G0/G1 phase through downregulation of PIM1, CDK2, CDK4 and retinoblastoma proteins. Importantly, calix[6]arene abolished signal transduction of Mer and AXL tyrosine kinase receptors, both of which are usually overexpressed in pancreatic cancer. Accordingly, inhibition of PI3K and mTOR was also observed, and these proteins are positively modulated by Mer and AXL. Despite decreasing the phosphorylation of AKT at Thr308, calix[6]arene caused an increase in phosphorylation at Ser473. These findings in conjunction with increased BiP and IRE1-α provide a molecular basis explaining the capacity of calix[6]arene to trigger endoplasmic reticulum stress and autophagic cell death. Our findings highlight calix[6]arene as a potential candidate for overcoming pancreatic cancer aggressiveness. Importantly, we provide evidence that calix[6]arene affects a broad array of key targets that are usually dysfunctional in pancreatic cancer, a highly desirable characteristic for chemotherapeutics. © 2013.

  11. Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.

    Science.gov (United States)

    Yin, Zhuoran; Raj, Divya; Saiepour, Nasrin; Van Dam, Debby; Brouwer, Nieske; Holtman, Inge R; Eggen, Bart J L; Möller, Thomas; Tamm, Joseph A; Abdourahman, Aicha; Hol, Elly M; Kamphuis, Willem; Bayer, Thomas A; De Deyn, Peter P; Boddeke, Erik

    2017-07-01

    Alzheimer's disease (AD) is strongly associated with microglia-induced neuroinflammation. Particularly, Aβ plaque-associated microglia take on an "activated" morphology. However, the function and phenotype of these Aβ plaque-associated microglia are not well understood. We show hyperreactivity of Aβ plaque-associated microglia upon systemic inflammation in transgenic AD mouse models (i.e., 5XFAD and APP23). Gene expression profiling of Aβ plaque-associated microglia (major histocompatibility complex II + microglia) isolated from 5XFAD mice revealed a proinflammatory phenotype. The upregulated genes involved in the biological processes (gene ontology terms) included: "immune response to external stimulus" such as Axl, Cd63, Egr2, and Lgals3, "cell motility", such as Ccl3, Ccl4, Cxcr4, and Sdc3, "cell differentiation", and "system development", such as St14, Trpm1, and Spp1. In human AD tissue with similar Braak stages, expression of phagocytic markers and AD-associated genes, including HLA-DRA, APOE, AXL, TREM2, and TYROBP, was higher in laser-captured early-onset AD (EOAD) plaques than in late-onset AD plaques. Interestingly, the nonplaque parenchyma of both EOAD and late-onset AD brains, the expression of above-mentioned markers were similarly low. Here, we provide evidence that Aβ plaque-associated microglia are hyperreactive in their immune response and phagocytosis in the transgenic AD mice as well as in EOAD brain tissue. We suggest that Aβ plaque-associated microglia are the primary source of neuroinflammation related to AD pathology. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Optimal implementation of best management practices to improve agricultural hydrology and water quality

    Science.gov (United States)

    Liu, Y.; Engel, B.; Collingsworth, P.; Pijanowski, B. C.

    2017-12-01

    Nutrient loading from the Maumee River watershed is a significant reason for the harmful algal blooms (HABs) problem in Lake Erie. Strategies to reduce nutrient loading from agricultural areas in the Maumee River watershed need to be explored. Best management practices (BMPs) are popular approaches for improving hydrology and water quality. Various scenarios of BMP implementation were simulated in the AXL watershed (an agricultural watershed in Maumee River watershed) using Soil and Water Assessment Tool (SWAT) and a new BMP cost tool to explore the cost-effectiveness of the practices. BMPs of interest included vegetative filter strips, grassed waterways, blind inlets, grade stabilization structures, wetlands, no-till, nutrient management, residue management, and cover crops. The following environmental concerns were considered: streamflow, Total Phosphorous (TP), Dissolved Reactive Phosphorus (DRP), Total Kjeldahl Nitrogen (TKN), and Nitrate+Nitrite (NOx). To obtain maximum hydrological and water quality benefits with minimum cost, an optimization tool was developed to optimally select and place BMPs by connecting SWAT, the BMP cost tool, and optimization algorithms. The optimization tool was then applied in AXL watershed to explore optimization focusing on critical areas (top 25% of areas with highest runoff volume/pollutant loads per area) vs. all areas of the watershed, optimization using weather data for spring (March to July, due to the goal of reducing spring phosphorus in watershed management plan) vs. full year, and optimization results of implementing BMPs to achieve the watershed management plan goal (reducing 2008 TP levels by 40%). The optimization tool and BMP optimization results can be used by watershed groups and communities to solve hydrology and water quality problems.

  13. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy.

    Science.gov (United States)

    Cackowski, Frank C; Eber, Matthew R; Rhee, James; Decker, Ann M; Yumoto, Kenji; Berry, Janice E; Lee, Eunsohl; Shiozawa, Yusuke; Jung, Younghun; Aguirre-Ghiso, Julio A; Taichman, Russell S

    2017-04-01

    Many prostate cancer (PCa) recurrences are thought to be due to reactivation of disseminated tumor cells (DTCs). We previously found a role of the TAM family of receptor tyrosine kinases TYRO3, AXL, and MERTK in PCa dormancy regulation. However, the mechanism and contributions of the individual TAM receptors is largely unknown. Knockdown of MERTK, but not AXL or TYRO3 by shRNA in PCa cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induced higher levels of histone H3K9me3 and H3K27me3, and induced a G1/G0 arrest, all of which are associated with dormancy. Similar effects were also observed with siRNA. Most importantly, knockdown of MERTK in PCa cells increased metastasis free survival in an intra-cardiac injection mouse xenograft model. MERTK knockdown also failed to inhibit PCa growth in vitro and subcutaneous growth in vivo, which suggests that MERTK has specificity for dormancy regulation or requires a signal from the PCa microenvironment. The effects of MERTK on the cell cycle and histone methylation were reversed by p38 inhibitor SB203580, which indicates the importance of MAP kinases for MERTK dormancy regulation. Overall, this study shows that MERTK stimulates PCa dormancy escape through a MAP kinase dependent mechanism, also involving p27, pluripotency transcription factors, and histone methylation. J. Cell. Biochem. 118: 891-902, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. To the question of modeling of wheels and rails wear processes

    Directory of Open Access Journals (Sweden)

    S.V. Myamlin

    2013-06-01

    Full Text Available Purpose. There is a need of wear process modeling in the wheel-rail system. This is related to the fact that the wear processes in this system are absolutely different in the initial and final stages. The profile change of rail and, especially, of the wheels caused by the wear significantly affects the rolling stock dynamics, traffic safety and the resource of the wheels and rails. Wear modeling and the traffic safety evaluation requires the accounting of the low frequency component forces (including the modeling of transitional areas affecting the wheel on the side of the rail and carriage in motion of rolling stock, so the statistical analysis is not possible. Methodology. The method of mathematical modeling of the wheel set and the rail interaction was used during the research conducting. Findings. As a result of the modeling of the wheel set motion on the rail track, the mathematic model with 19 freedom degrees was obtained. This model takes into account the axle torque and studies wheels constructions as the components of the mechanical systems, consisting of a hub and tire. Originality. The mathematic model allows evaluating the wear degree of the wheels and rails when using on the rolling stock not only all-metal wheel sets, but also compound ones with the use of spring wheels and independent rotation of semi-axes with the wheels. Practical value. The development of the improved mathematical model of freight car wheel set motion with differential rotation of the wheels and compound axles allows studying the wear processes of wheels and rails.

  15. Heavy and Overweight Vehicle Defects Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Siekmann, Adam [ORNL; Capps, Gary J [ORNL

    2012-12-01

    The Federal Highway Administration (FHWA), along with the Federal Motor Carrier Safety Administration (FMCSA), has an interest in overweight commercial motor vehicles, how they affect infrastructure, and their impact on safety on the nation s highways. To assist both FHWA and FMCSA in obtaining more information related to this interest, data was collected and analyzed from two separate sources. A large scale nationwide data collection effort was facilitated by the Commercial Vehicle Safety Alliance as part of a special study on overweight vehicles and an additional, smaller set, of data was collected from the state of Tennessee which included a much more detailed set of data. Over a six-month period, 1,873 Level I inspections were performed in 18 different states that volunteered to be a part of this study. Of the 1,873 inspections, a vehicle out-of-service (OOS) violation was found on 44.79% of the vehicles, a rate significantly higher than the national OOS rate of 27.23%. The main cause of a vehicle being placed OOS was brake-related defects, with approximately 30% of all vehicles having an OOS brake violation. Only about 4% of vehicles had an OOS tire violation, and even fewer had suspension and wheel violations. Vehicle weight violations were most common on an axle group as opposed to a gross vehicle weight violation. About two thirds of the vehicles cited with a weight violation were overweight on an axle group with an average amount of weight over the legal limit of about 2,000 lbs. Data collection is scheduled to continue through January 2014, with more potentially more states volunteering to collect data. More detailed data collections similar to the Tennessee data collection will also be performed in multiple states.

  16. An investigation into the mechanism of the polygonal wear of metro train wheels and its effect on the dynamic behaviour of a wheel/rail system

    Science.gov (United States)

    Jin, Xuesong; Wu, Lei; Fang, Jianying; Zhong, Shuoqiao; Ling, Liang

    2012-12-01

    This paper presents a detailed investigation conducted into the mechanism of the polygonal wear of metro train wheels through extensive experiments conducted at the sites. The purpose of the experimental investigation is to determine from where the resonant frequency that causes the polygonal wear of the metro train wheels originates. The experiments include the model tests of a vehicle and its parts and the tracks, the dynamic behaviour test of the vehicle in operation and the observation test of the polygonal wear development of the wheels. The tracks tested include the viaducts and the tunnel tracks. The structure model tests show that the average passing frequency of a polygonal wheel is approximately close to the first bending resonant frequency of the wheelset that is found by the wheelset model test and verified by the finite element analysis of the wheelset. Also, the dynamic behaviour test of the vehicle in operation indicates the main frequencies of the vertical acceleration vibration of the axle boxes, which are dominant in the vertical acceleration vibration of the axle boxes and close to the passing frequency of a polygonal wheel, which shows that the first bending resonant frequency of the wheelset is very exciting in the wheelset operation. The observation test of the polygonal wear development of the wheels indicates an increase in the rate of the polygonal wear of the wheels after their re-profiling. This paper also describes the dynamic models used for the metro vehicle coupled with the ballasted track and the slab track to analyse the effect of the polygonal wear of the wheels on the wheel/rail normal forces.

  17. The Potential and Beneficial Use of Weigh-In-Motion (WIM) Systems Integrated with Radio Frequency Identification (RFID) Systems for Characterizing Disposal of Waste Debris to Optimize the Waste Shipping Process

    International Nuclear Information System (INIS)

    Abercrombie, Robert K.; Buckner, Dooley Jr.; Newton, David D.

    2010-01-01

    The Oak Ridge National Laboratory (ORNL) Weigh-In-Motion (WIM) system provides a portable and/or semi-portable means of accurately weighing vehicles and its cargo as each vehicle crosses the scales (while in motion), and determining (1) axle weights and (2) axle spacing for vehicles (for determination of Bridge Formula compliance), (3) total vehicle/cargo weight and (4) longitudinal center of gravity (for safety considerations). The WIM system can also weigh the above statically. Because of the automated nature of the WIM system, it eliminates the introduction of human errors caused by manual computations and data entry, adverse weather conditions, and stress. Individual vehicles can be weighed continuously at low speeds (approximately 3-10 mph) and at intervals of less than one minute. The ORNL WIM system operates and is integrated into the Bethel Jacobs Company Transportation Management and Information System (TMIS, a Radio-Frequency Identification (RFID) enabled information system). The integrated process is as follows: Truck Identification Number and Tare Weight are programmed into a RFID Tag. Handheld RFID devices interact with the RFID Tag, and Electronic Shipping Document is written to the RFID Tag. The RFID tag read by an RFID tower identifies the vehicle and its associated cargo, the specific manifest of radioactive debris for the uniquely identified vehicle. The weight of the cargo (in this case waste debris) is calculated from total vehicle weight information supplied from WIM to TMIS and is further processed into the Information System and kept for historical and archival purposes. The assembled data is the further process in downstream information systems where waste coordination activities at the Y-12 Environmental Management Waste Management Facility (EMWMF) are written to RFID Tag. All cycle time information is monitored by Transportation Operations and Security personnel.

  18. A new method for designing floor slabs on grade due to the difficulty of applying simplified design methods, amongst them being the Portland Cement Association (PCA and Wire Reinforcement Institute (WRI methods

    Directory of Open Access Journals (Sweden)

    Hugo Ernesto Camero Sanabrial

    2007-01-01

    Full Text Available This article presents a methodology for designing slabs on grade for industrial floors where there is an eccentricity between the slab centroid and the gravity centre loads of the loaded axle of forklift trucks travelling over the floor. An example was used for analysing how Portland Cement Association (PCA and the Wire Reinforcement Institute (WRI methods are inadequate for designing floors sublected to this condition. The new proposal for designing slabs on grade for industrial floors has been called the Camero method. An example of an industrial floor designed to be capable of sustaining an infinite number of load applications (or 50-year life was compared to the results of the Camero method and PCA and WRI’s simplified methods. Industrial floors should be capable of sustaining an infinite number of load applications (50-year life if designed with the Camero method; on the other hand, if designed using PCA and WRI methods they will only last one year (in this example the number of axle load applications in a 1-year period was equal to the number of allowable repetitions because they will not be able to sustain an infinite number of load applications. It was concluded that designing plain concrete slabs (without reinforcement on grade according to PCA and the WRI methods leads to slab fatigue, even though extreme fibre stress should not exceed 50 percent (50% of static modulus of concrete rupture and slabs should sustain an infinite number of load repetitions (infinite amount of forklift truck traffic were considered parameters in their design.

  19. MicroRNA expression and clinical outcome of small cell lung cancer.

    Directory of Open Access Journals (Sweden)

    Jih-Hsiang Lee

    Full Text Available The role of microRNAs in small-cell lung carcinoma (SCLC is largely unknown. miR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types. However, its therapeutic implication has never been studied in SCLC, a cancer type with frequent dysfunction of p53. We investigated the expression of a panel of 7 microRNAs (miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a in 31 SCLC tumors, 14 SCLC cell lines, and 26 NSCLC cell lines. We observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines. The expression of the 7 microRNAs was unrelated to SCLC patients' clinical characteristics and was neither prognostic in term of overall survival or progression-free survival nor predictive of treatment response. Overexpression or downregulation of miR-34a did not influence SCLC cell viability. The expression of these 7 microRNAs also did not predict in vitro sensitivity to cisplatin or etoposide in SCLC cell lines. Overexpression or downregulation of miR-34a did not influence sensitivity to cisplatin or etoposide in SCLC cell lines. In contrast to downregulation of the miR-34a target genes cMET and Axl by overexpression of miR-34a in NSCLC cell lines, the intrinsic expression of cMET and Axl was low in SCLC cell lines and was not influenced by overexpression of miR-34a. Our results suggest that the expression of the 7 selected microRNAs are not prognostic in SCLC patients, and miR-34a is unrelated to the malignant behavior of SCLC cells and is unlikely to be a therapeutic target.

  20. [Occupational health administrative coordination a propos of a case: brake linings with asbestos in a company].

    Science.gov (United States)

    García Gómez, Montserrat; Alonso Urreta, Iciar; Antón Tomey, Carlos; Bosque Peralta, Isabel; García-Gutierrez, María Jesús; Luna Lacarta, Francisco José; Martínez Arguisuelas, Nieves; Mena Marín, María Luisa; Vázquez Cortizo, Margarita

    2018-04-10

    The current structure of the Spanish State of Autonomies is characterized by institutional pluralism and the autonomy of the different public administrations. In this context, the principle of coordination is fundamental for the cohesion of the system, but experience shows that its implementation is difficult. This paper examines the set of actions carried out by the administrations in relation to an occupational and public health problem raised in March 2016. The Public Health General Direction of Aragon's Government was informed of a possible use of brake linings with asbestos to manufacture axles for agricultural machinery by a Company from Zaragoza; the collaboration from Aragon's Institute of Occupational Safety and Health, the Industry Department and the Labour and Social Security Inspectorate were asked; the joint action of these administrations detected the use of several models of brake linings with a content of 2-5% of Chrysotile. The brake linings came from a Chinese company. The axles nated are sold in several Spanish Autonomous Communities. A national alert was activated by the SIRIPQ (System of Rapid Exchange of Information on Chemical Products) which is coordinated by the Ministry of Health, Social Services and Equality. Several measures were taken including: ceasing the work with the brake linings, the replacement of brake linings with asbestos, the immobilization of brake linings in the company by application of the REACH Reglament, etc. This case shows that the cooperation and co-responsibility of public administrations from different territorial, sectoral and competence areas allows improving the occupational risks prevention and the public health.

  1. A Novel Vehicle Classification Using Embedded Strain Gauge Sensors.

    Science.gov (United States)

    Zhang, Wenbin; Wang, Qi; Suo, Chunguang

    2008-11-05

    This paper presents a new vehicle classification and develops a traffic monitoring detector to provide reliable vehicle classification to aid traffic management systems. The basic principle of this approach is based on measuring the dynamic strain caused by vehicles across pavement to obtain the corresponding vehicle parameters - wheelbase and number of axles - to then accurately classify the vehicle. A system prototype with five embedded strain sensors was developed to validate the accuracy and effectiveness of the classification method. According to the special arrangement of the sensors and the different time a vehicle arrived at the sensors one can estimate the vehicle's speed accurately, corresponding to the estimated vehicle wheelbase and number of axles. Because of measurement errors and vehicle characteristics, there is a lot of overlap between vehicle wheelbase patterns. Therefore, directly setting up a fixed threshold for vehicle classification often leads to low-accuracy results. Using the machine learning pattern recognition method to deal with this problem is believed as one of the most effective tools. In this study, support vector machines (SVMs) were used to integrate the classification features extracted from the strain sensors to automatically classify vehicles into five types, ranging from small vehicles to combination trucks, along the lines of the Federal Highway Administration vehicle classification guide. Test bench and field experiments will be introduced in this paper. Two support vector machines classification algorithms (one-against-all, one-against-one) are used to classify single sensor data and multiple sensor combination data. Comparison of the two classification method results shows that the classification accuracy is very close using single data or multiple data. Our results indicate that using multiclass SVM-based fusion multiple sensor data significantly improves the results of a single sensor data, which is trained on the whole

  2. Integrating the teaching-learning process of Occupational Therapy students and the care of mothers of babies at risk during hospitalization

    Directory of Open Access Journals (Sweden)

    Regina Helena Vitale Torkomian Joaquim

    2016-03-01

    Full Text Available Introduction: This study approaches the process of teaching-learning of a group of occupational therapy students to act in the care of mothers of babies at risk in the hospital context. It is linked to a community project, supported by the ‘Programa de Extensao Universitaria’. Objective: It aimed to qualify the students for understanding the risk rising, the initial mother-baby bond in the hospital environment, the monitoring of the child development and troubleshooting, as well as to see themselves as subjects of their own training. Method: Participants were six students, three teachers, 26 mothers and their 28 babies. The procedures had been developed in three articulated axles: practice, theoretical basis and invitation to reflection, each axle guided by one of three teachers. There were 65 meetings; 27 of the group of mothers, 11 of the group for theoretical overviews and 27 of the reflection group. Six students have completed their participation in the study, having achieved qualification for the care of occupational therapy to mothers of babies at risk during hospitalization and at home after discharge, as well as the co-responsibility with people and served family. All 26 mothers received care in the nursery; 25 of them in addition to the nursery, were treated at mothers group and 6 in addition to the nursery and the group, were visited at home. Conclusion: This study made it possible to contemplate two subjects with the same priority: the mother and her baby, as subjects of the attention and care of an occupational therapist and the student, as the subject of the attention and care of the teacher of occupational therapy.

  3. Total dynamic response of a PSS vehicle negotiating asymmetric road excitations

    Science.gov (United States)

    Zhu, Jian Jun; Khajepour, Amir; Esmailzadeh, Ebrahim

    2012-12-01

    A planar suspension system (PSS) is a novel automobile suspension system in which an individual spring-damper strut is implemented in both the vertical and longitudinal directions, respectively. The wheels in a vehicle with such a suspension system can move back and forth relative to the chassis. When a PSS vehicle experiences asymmetric road excitations, the relative longitudinal motion of wheels with respect to the chassis in two sides of the same axle are not identical, and thus the two wheels at one axle will not be aligned in the same axis. The total dynamic responses, including those of the bounce, pitch and the roll of the PSS vehicle, to the asymmetric road excitation may exhibit different characteristics from those of a conventional vehicle. This paper presents an investigation into the comprehensive dynamic behaviour of a vehicle with the PSS, in such a road condition, on both the straight and curved roads. The study was carried out using an 18 DOF full-car model incorporating a radial-spring tyre-ground contact model and a 2D tyre-ground dynamic friction model. Results demonstrate that the total dynamic behaviour of a PSS vehicle is generally comparable with that of the conventional vehicle, while PSS exhibits significant improvement in absorbing the impact forces along the longitudinal direction when compared to the conventional suspension system. The PSS vehicle is found to be more stable than the conventional vehicle in terms of the directional performance against the disturbance of the road potholes on a straight line manoeuvre, while exhibiting a very similar handling performance on a curved line.

  4. Configurations Of Tire Pressure On The Pavement For Commercial Vehicles: Calculation Of The ‘N’ Number And The Consequences On Pavement Performance

    Directory of Open Access Journals (Sweden)

    Paulo Boulos Filho

    2016-07-01

    Full Text Available Road traffic has a high variety of types of vehicles and cargo transported. One of the main difficulties in pavement design is forecasting the changes in traffic over time and evaluating the comparative deterioration power of the various loads with axle and tire settings and different levels of repetition. The road environment in Brazil, as we know, is the main means of the country's cargo transportation. Throughout the 1990s and 2000s the road modal accounted for over 60% of the total cargo transported in the country leaving the unbalanced Brazilian transport matrix with almost exclusive investments in such means of transportation. According to CNT 2012, which conducted a survey in approximately 45% of the paved network, evaluating the pavement functional conditions, traffic signs and geometry, 46% of the country’s road network has some type of deficiency in the pavement. The goal of this work is to contribute to a better understanding of the complex influence of traffic in the design and service life of the pavement. The load pressure of commercial vehicle tires over the pavement has increased in recent decades. A more apparent effect of this increase in tire pressure would be the change in the pavement- tire contact area which in turn may result in an increase in the contact load between tire and pavement and other harmful effects on the structure. This study aims to determine the effect on the calculation of the N number, or the number of solicitations of the standard axle on the road pavement, measuring the overload as a percentage of the legal load indicated by a scale. In short, we calculate how an increase in the overload percentage in comparison with the allowable load will influence the decrease of the calculated durability of the pavement designed for the highway.

  5. A Novel Vehicle Classification Using Embedded Strain Gauge Sensors

    Directory of Open Access Journals (Sweden)

    Qi Wang

    2008-11-01

    Full Text Available Abstract: This paper presents a new vehicle classification and develops a traffic monitoring detector to provide reliable vehicle classification to aid traffic management systems. The basic principle of this approach is based on measuring the dynamic strain caused by vehicles across pavement to obtain the corresponding vehicle parameters – wheelbase and number of axles – to then accurately classify the vehicle. A system prototype with five embedded strain sensors was developed to validate the accuracy and effectiveness of the classification method. According to the special arrangement of the sensors and the different time a vehicle arrived at the sensors one can estimate the vehicle’s speed accurately, corresponding to the estimated vehicle wheelbase and number of axles. Because of measurement errors and vehicle characteristics, there is a lot of overlap between vehicle wheelbase patterns. Therefore, directly setting up a fixed threshold for vehicle classification often leads to low-accuracy results. Using the machine learning pattern recognition method to deal with this problem is believed as one of the most effective tools. In this study, support vector machines (SVMs were used to integrate the classification features extracted from the strain sensors to automatically classify vehicles into five types, ranging from small vehicles to combination trucks, along the lines of the Federal Highway Administration vehicle classification guide. Test bench and field experiments will be introduced in this paper. Two support vector machines classification algorithms (one-against-all, one-against-one are used to classify single sensor data and multiple sensor combination data. Comparison of the two classification method results shows that the classification accuracy is very close using single data or multiple data. Our results indicate that using multiclass SVM-based fusion multiple sensor data significantly improves

  6. In-Service Evaluation of HVOF Coated Main Landing Gear on Navy P-3 Aircraft

    Science.gov (United States)

    Devereaux, jon L.; Forrest, Clint

    2008-01-01

    Due to the environmental and health concerns with Electroplated Hard Chrome (EHC), the Hard Chrome Alternatives Team (HCAT) has been working to provide an alternative wear coating for EHC. The US Navy selected Tungsten-Carbide Cobalt (WC- 17Co) High Velocity Oxy-Fuel (HVOF) thermal spray coating for this purpose and completed service evaluations on select aircraft components to support the HCAT charter in identifying an alternative wear coating for chrome plating. Other benefits of WC-Co thermal spray coatings over EHC are enhanced corrosion resistance, improved durability, and exceptional wear properties. As part of the HCAT charter and to evaluate HVOF coatings on operational Navy components, the P-3 aircraft was selected for a service evaluation to determine the coating durability as compared to chrome plating. In April 1999, a VP-30 P-3 aircraft was outfitted with a right-hand Main Landing Gear (MLG) shock strut coated with WCCo HYOF thermal spray applied to the piston barrel and four axle journals. The HVOF coating on the piston barrel and axle journals was applied by Southwest United Industries, Inc. This HVOF coated strut assembly has since completed 6,378 landings. Teardown analysis .for this WC-Co HVOF coated MLG asset is significant in assessing the durability of this wear coating in service relative to EHC and to substantiate Life Cycle Cost (LCC) data to support a retrograde transition from EHC to HVOF thermal spray coatings. Findings from this teardown analysis may also benefit future transitions to HVOF thermal spray coatings by identifying enhancements to finishing techniques, mating bearing and liner material improvements, improved seal materials, and improvements in HVOF coating selection.

  7. Diseño de losas de hormigón con geometría optimizada Design of concrete pavement with optimized slab geometry

    Directory of Open Access Journals (Sweden)

    Juan Pablo Covarrubias V.

    2012-12-01

    condiciones de cargas mecánicas y térmicas en diferentes posiciones. El agrietamiento de las losas se determina calculando la fatiga del hormigón y los modelos utilizados por la guía de diseño AASHTO del año 2007 y mediante calibración en secciones de prueba a gran escala. La nueva metodología diseña losas de hormigón que en promedio son 7 cm más delgadas para vías de alto tráfico en relación con el diseño tradicional de pavimentos AASHTO (1993. El método de diseño también es capaz de diseñar de manera eficiente pavimentos de hormigón para vías de menor volumen de tráfico que no son cubiertos con los actuales métodos de diseño de pavimento dando una alternativa a soluciones en asfalto.A new technology has been developed to design concrete pavements, which reduces slabs' thickness and optimizes their sizes, because of trucks axles' geometry. The design is supported by a gravel base treated with concrete or asphalt. It assumes there is no adherence between the base (existing pavement and the concrete slab. The core principle of this design method consists of designing a slab size, so that no more than one wheel set stays on a given slab, thus minimizing the critical tensile stress on the surface. Test segments have been built on a large scale and they have been tested under accelerated loads, with concrete thickness of 8, 15 and 20 cm, all of them having a gravel base and non-adhered asphaltic layers. Tests demonstrated that a reduced-size slab, of low thickness, might bear a considerable amount of equivalent axles before cracking takes place. Concrete slabs on gravel bases with 20 cm thickness did not suffer from cracking, in spite of being tested under more than 50 millions of equivalent axles. Slabs of 15 cm thickness suffered from cracking when tested under an average of 12 millions equivalent axles, while slabs of 8 cm thickness endured 75,000 equivalent axles before the first cracking took place. Besides the executed tests demonstrated that fiber

  8. DOE Hybrid and Electric Vehicle Test Platform

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Yimin [Advanced Vehicle Research Center, Danville, VA (United States)

    2012-03-31

    Based on the contract NT-42790 to the Department of Energy, “Plug-in Hybrid Ethanol Research Platform”, Advanced Vehicle Research Center (AVRC) Virginia has successfully developed the phase I electric drive train research platform which has been named as Laboratory Rapid Application Testbed (LabRAT). In phase II, LabRAT is to be upgraded into plug-in hybrid research platform, which will be capable of testing power systems for electric vehicles, and plug-in hybrid electric vehicles running on conventional as well as alternative fuels. LabRAT is configured as a rolling testbed with plentiful space for installing various component configurations. Component connections are modularized for flexibility and are easily replaced for testing various mechanisms. LabRAT is designed and built as a full functional vehicle chassis with a steering system, brake system and four wheel suspension. The rear drive axle offers maximum flexibility with a quickly changeable gear ratio final drive to accommodate different motor speed requirements. The electric drive system includes an electric motor which is mechanically connected to the rear axle through an integrated speed/torque sensor. Initially, a 100 kW UQM motor and corresponding UQM motor controller is used which can be easily replaced with another motor/controller combination. A lithium iron phosphate (LiFePO4) battery pack is installed, which consists of 108 cells of 100 AH capacity, giving the total energy capacity of 32.5 kWh. Correspondingly, a fully functional battery management system (BMS) is installed to perform battery cell operation monitoring, cell voltage balancing, and reporting battery real time operating parameters to vehicle controller. An advanced vehicle controller ECU is installed for controlling the drive train. The vehicle controller ECU receives traction or braking torque command from driver through accelerator and brake pedal position sensors and battery operating signals from the BMS through CAN BUS

  9. The Development of Power Distribution Law in Transmission of Active Road Based on the Analysis of the Power Factors in the Coupling Device

    Directory of Open Access Journals (Sweden)

    V. A. Gorelov

    2016-01-01

    Full Text Available Effective delivery of indivisible bulky and heavy loads whose weight can reach hundreds tons is of particular importance for development of various sectors of economy and support of defense capability. Special road trains provide open road transportation and off-road haulage of this kind of goods, but in difficult traffic environment their using capabilities are significantly restricted by a lack of the road-ability. For a road train to reach the better road-ability is possible by increasing the number of drive wheels. This can be achieved through the use of an activetrailer as its part. The effectiveness of using this drive may be estimated through comparison of the road train road-ability with the turned on and turned off passive and active semitrailer in different road environment. A mathematical model of the dynamics of the two-link semitrailer truck was created to solve the problem of comparing dynamic characteristics of the road trains with the passive and active semitrailer. The developed mathematical model of the four-axle tractor and three-axle semitrailer was implemented in the MATLAB® Simulink. It was revealed that in some traffic environments it is advisable to disable the semitrailer drive. A drive control algorithm of semitrailer wheels based on the analysis of the forces in the coupling device was proposed. Data from the sensors installed in the pin of the coupling device serve as a primary source of information for the control system. Test runs enabled us to define control limits for the drive control system. The article considers three cases to use the power of traction motors of the semitrailer in a predetermined range. A number of numerical experiments have been conducted to define dynamic qualities of the road trains in different cases of using semitrailer power. The analysis of results allowed us to draw conclusion that using a system of the semitrailer drive to be connected enables increasing efficiency of the road train

  10. Analysis of Traffic Noise along Oyemekun - Oba-Adesida Road Akure Ondo State Nigeria

    Directory of Open Access Journals (Sweden)

    O. J Oyedepo

    2013-03-01

    Full Text Available The primary aim of the research is to quantify and analyze the traffic noise emissions along Oba-Adesida –Oyemekun Road. Measurements of noise were recorded in decibel (dBA using digital sound level meters (IEC651 Type 2. While, the traffic volume and spot speed were obtained using cine –camera at six selected locations namely Alagbaka(L1, Biological Garden(L2, Adegbola(L3, Ondo Bye Pass(L4, Ilesha Garage(L5 and FUTA junction(L6 along ObaAdesida- Oyemekun road during the peak period(7:30am -8:30 am & 4:00pm-5:00pm and off peak period(11:30pm- 12:30pm, repeated 3-5 times to account for time-fluctuation of these variables. All measurements were taken on a weighting frequency network, at a height of about 1.5m from the ground level. The vehicles were divided into five categories namely Cars, buses, motorcycles,2-axle load, and 3-axle loads; and were converted into “Passenger Car Units” (PCU by multiplying with recommended factors in accordance with Nigerian Federal Highway Capacity Manual 2006.The average L10(dBA are 72.8, 73.8, 73.4, 74.4, 73.9, and 75.0dBA ; while average combine sound pressure level(SPL in dBA are 76, 77, 78, 78, 77, and 78dBA for L1, L2, L3, L4, L5,and L6 respectively. Findings indicated that traffic generated noise pollution is at or above, the standard outdoor limits in most locations and area can adversely affect the welfare activities. The present study revealed that the study area is getting noisier due to high traffic density and lack of traffic management, practical action to limit and control the exposure to environmental noise are essential. However, road traffic noise by treatments at source (such as to reduce engine noise, exhaust pipe noise etc. is to be encouraged as the principal method of control. The techniques include road design, the management of traffic flow and the use of screens and barriers.

  11. Effects of traffic-induced soil compaction on crop growth and soil properties

    Science.gov (United States)

    Baibay, Amélia; Ren, Lidong; D'Hose, Tommy; De Pue, Jan; Ruysschaert, Greet; Cornelis, Wim

    2017-04-01

    Traffic-induced soil compaction on arable soils constitutes a major threat for agricultural productivity and the environmental quality of the soil, water and atmosphere. The objective of this work is to evaluate a set of prevention strategies for agricultural traffic under real farming conditions. To that end, a one-pass traffic experiment was conducted near Ghent, Belgium in winter 2015 on a sandy loam (haplic Luvisol; 43% sand, 47% silt, 10% clay). Winter rye (Secale cereale L.), which promotes the removal of residual soil nitrogen and thus reduces the potential for nitrogen leaching, was sown as cover crop using different tractor and weather settings on different field lanes: dry (D, 0.16 m3 m-3) or wet (W, 0.20-0.23 m3 m-3) conditions, normal (N, 65 cm width, axle load 8520 kg) or wide (W, 90 cm width, axle load 8520 kg) tires and high (HP, 1.4 bars for N, 1.0 bar for W) or low (LP, 1.0 bar for N, 0.5 bar for W) inflation pressure. Subsequently, crop biomass, root density and a set of hydrophysical properties (penetration resistance, saturated hydraulic conductivity and water retention at 15, 35 and 55 cm depth) were measured. Bulk density, soil quality indicators (such as air capacity) and the pore size distribution were also calculated. Results showed significant biomass reduction (p agricultural operations on the field, and high values (3.5 to 4 MPa) were found in the subsoil too. Moreover, bulk densities were higher for all treatments (up to 1.8 Mg m-3) compared to the controls (˜1.55 Mg m-3). Saturated hydraulic conductivities were very small (<< 10 cm/d), especially for the treatments. The dry treatment also showed better values than the wet ones at 15 cm. Water retention curves tended to show decreased water content at low suctions for the treatments (mainly at 15 cm), which could reflect on a reduction of macropores and their continuity. Soil quality parameters also showed better values in the control plots. These observations support an overall

  12. Lessons learned from failure analysis

    International Nuclear Information System (INIS)

    Le May, I.

    2006-01-01

    Failure analysis can be a very useful tool to designers and operators of plant and equipment. It is not simply something that is done for lawyers and insurance companies, but is a tool from which lessons can be learned and by means of which the 'breed' can be improved. In this presentation, several failure investigations that have contributed to understanding will be presented. Specifically, the following cases will be discussed: 1) A fire at a refinery that occurred in a desulphurization unit. 2) The failure of a pipeline before it was even put into operation. 3) Failures in locomotive axles that took place during winter operation. The refinery fire was initially blamed on defective Type 321 seamless stainless steel tubing, but there were conflicting views between 'experts' involved as to the mechanism of failure and the writer was called upon to make an in-depth study. This showed that there were a variety of failure mechanism involved, including high temperature fracture, environmentally-induced cracking and possible manufacturing defects. The unraveling of the failure sequence is described and illustrated. The failure of an oil transmission was discovered when the line was pressure tested some months after it had been installed and before it was put into service. Repairs were made and failure occurred in another place upon the next pressure test being conducted. After several more repairs had been made the line was abandoned and a lawsuit was commenced on the basis that the steel was defective. An investigation disclosed that the material was sensitive to embrittlement and the causes of this were determined. As a result, changes were made in the microstructural control of the product to avoid similar problems in future. A series of axle failures occurred in diesel electric locomotives during winter. An investigation was made to determine the nature of the failures which were not by classical fatigue, nor did they correspond to published illustrations of Cu

  13. Impact of train speed on the mechanical behaviours of track-bed materials

    Directory of Open Access Journals (Sweden)

    Francisco Lamas-Lopez

    2017-10-01

    Full Text Available For the 30,000 km long French conventional railway lines (94% of the whole network, the train speed is currently limited to 220 km/h, whilst the speed is 320 km/h for the 1800 km long high-speed lines. Nowadays, there is a growing need to improve the services by increasing the speed limit for the conventional lines. This paper aims at studying the influence of train speed on the mechanical behaviours of track-bed materials based on field monitoring data. Emphasis is put on the behaviours of interlayer and subgrade soils. The selected experimental site is located in Vierzon, France. Several sensors including accelerometers and soil pressure gauges were installed at different depths. The vertical strains of different layers can be obtained by integrating the records of accelerometers installed at different track-bed depths. The experimentation was carried out using an intercity test train running at different speeds from 60 km/h to 200 km/h. This test train was composed of a locomotive (22.5 Mg/axle and 7 “Corail” coaches (10.5 Mg/axle. It was observed that when the train speed was raised, the loadings transmitted to the track-bed increased. Moreover, the response of the track-bed materials was amplified by the speed rise at different depths: the vertical dynamic stress was increased by about 10% when the train speed was raised from 60 km/h to 200 km/h for the locomotive loading, and the vertical strains doubled their quasi-static values in the shallow layers. Moreover, the stress–strain paths were estimated using the vertical stress and strain for each train speed. These loading paths allowed the resilient modulus Mr to be determined. It was found that the resilient modulus (Mr was decreased by about 10% when the train speed was increased from 100 km/h to 200 km/h. However, the damping ratio (Dr kept stable in the range of speeds explored.

  14. Variability in bimanual wheelchair propulsion: consistency of two instrumented wheels during handrim wheelchair propulsion on a motor driven treadmill

    Science.gov (United States)

    2013-01-01

    Background Handrim wheelchair propulsion is a complex bimanual motor task. The bimanually applied forces on the rims determine the speed and direction of locomotion. Measurements of forces and torques on the handrim are important to study status and change of propulsion technique (and consequently mechanical strain) due to processes of learning, training or the wheelchair configuration. The purpose of this study was to compare the simultaneous outcomes of two different measurement-wheels attached to the different sides of the wheelchair, to determine measurement consistency within and between these wheels given the expected inter- and intra-limb variability as a consequence of motor control. Methods Nine able-bodied subjects received a three-week low-intensity handrim wheelchair practice intervention. They then performed three four-minute trials of wheelchair propulsion in an instrumented hand rim wheelchair on a motor-driven treadmill at a fixed belt speed. The two measurement-wheels on each side of the wheelchair measured forces and torques of one of the two upper limbs, which simultaneously perform the push action over time. The resulting data were compared as direct output using cross-correlation on the torque around the wheel-axle. Calculated push characteristics such as power production and speed were compared using an intra-class correlation. Results Measured torque around the wheel axle of the two measurement-wheels had a high average cross-correlation of 0.98 (std=0.01). Unilateral mean power output over a minute was found to have an intra-class correlation of 0.89 between the wheels. Although the difference over the pushes between left and right power output had a high variability, the mean difference between the measurement-wheels was low at 0.03 W (std=1.60). Other push characteristics showed even higher ICC’s (>0.9). Conclusions A good agreement between both measurement-wheels was found at the level of the power output. This indicates a high

  15. PACING DEVICE FOR SWIMMING. MECHANICAL CONSTRUCTION OF CONSTANT SPEED

    Directory of Open Access Journals (Sweden)

    MESSINIS S.

    2010-04-01

    Full Text Available The pace in swimming is very important because it allows swimmers to allocate their forces accordingly, and therefore a distance to travel as quickly as possible. The training pace at different swimmingspeeds and combinations thereof, is an important part of training before the competitions.The definition and maintenance of the stable and swimmer specific speed is difficult to achieve and requires considerable effort and experience. To determine the desired rate of accuracy by the researchers and their coaches used till now, various audio and visual media.However, some of these institutions did not very accurately measure the rate and not all styles of swimming, while other aspects affect the proper swimming. In this construction, a key objective is to solve the problems occurring in the previous constructions, the modern technological development of them and the adaption of the specificities of different swimming styles.This device consists of an electro 3 / 8 of the horse, a flange, a single inverter from 3 / 8 to ½ of the horse, pulleys with taper Bush, flange axle, pulleys, platforms and a 52 meters cable. The assembly and operation is as follows: At the edge of the pool next to the platform is placed the base of pulleys, the electro setis connected to the inverter and the axle flange.Precisely opposite is positioned the other base. Along the pool «moves» the cable that connects the two bases, located 150 cm above the water. A fixed point on the cable is marked with paint in order to be visible to the swimmer during backstroke swimming while for other styles we adapt a lamination at the cable vertically inthe pool, above the surface a sheet of 15 cm which is painted with strong color that is visible from the athlete and will precede him. Setting the speed with inverter it starts from one end of the tank leading to the other, doing a circular motion.The swimmer is required to follow the marked point of the cable in the backstroke or

  16. Scleral Cross-Linking Using Riboflavin UVA Irradiation for the Prevention of Myopia Progression in a Guinea Pig Model: Blocked Axial Extension and Altered Scleral Microstructure.

    Directory of Open Access Journals (Sweden)

    Shuai Liu

    Full Text Available To develop methods of collagen cross-linking (CXL in the sclera for the treatment of progressive myopia and to investigate the biomechanical and histological changes that occur in as a result.Twenty 14-day-old guinea pigs were divided into 3 groups: the cross-linking group (CL, n = 8, non cross-linking group (NCL, n = 8, and control group (n = 4. The scleras of the right eyes of the guinea pigs in the CL group were surgically exposed and riboflavin was dropped onto the irradiation zone for 20 seconds prior to ultraviolet-A (UVA irradiation. The same procedure was conducted on the NCL group but without UVA irradiation. No procedure was conducted on the control group. The right eyes of the guinea pigs in the CL and NCL groups were then fitted with -10.00DS optics for six weeks. Retinoscopy and the axial lengths (AXL were measured at baseline, and at the second, fourth and sixth weeks post-treatment in all three groups. All animal subjects were euthanized after the sixth week and then biomechanical and histopathological examinations of the scleras were conducted.The mean AXL of the NCL group was longer than both the control and CL groups at six weeks (P = 0.001. The mean refractive error in the NCL group was statistically significantly more negative than both the control and the CL groups at six weeks (P = 0.001. The scleral collagen fiber arrangements of the CL and control groups were denser and more regularly distributed than the NCL group. Ultimate stress of the sclera was lowest in the NCL group, followed by the CL then the control group (P<0.05. Ultimate strain (% of the sclera was lowest in the CL group followed by the NCL and then the control group (P<0.05.Our study demonstrates that scleral CXL using riboflavin UVA irradiation effectively prevents the progression of myopia by increasing scleral biomechanical strength in a guinea pig model.

  17. USDOE Top-of-Rail Lubricant Project; FINAL

    International Nuclear Information System (INIS)

    Mohumad F. Alzoubi; George R. Fenske; Robert A. Erck; Amrit S. Boparai

    2002-01-01

    Lubrication of wheel/rail systems has been recognized for the last two decades as a very important issue for railroads. Energy savings and less friction and wear can be realized if a lubricant can be used at the wheel/rail interface. On the other hand, adverse influences are seen in operating and wear conditions if improper or excessive lubrication is used. Also, inefficiencies in lubrication need to be avoided for economic and environmental reasons. The top-of-rail (TOR) lubricant concept was developed by Texaco Corporation to lubricate wheels and rails effectively and efficiently. Tranergy Corporation has been developing its SENTRAEN 2000(trademark) lubrication system for the last ten years, and this revolutionary new high-tech on-board rail lubrication system promises to dramatically improve the energy efficiency, performance, safety, and track environment of railroads. The system is fully computer-controlled and ensures that all of the lubricant is consumed as the end of the train passes. Lubricant quantity dispensed is a function of grade, speed, curve, and axle load. Tranergy also has its LA4000(trademark) wheel and rail simulator, a lubrication and traction testing apparatus. The primary task of this project was collecting and analyzing the volatile and semivolatile compounds produced as the lubricant was used. The volatile organic compounds were collected by Carbotrap cartridges and analyzed by adsorption and gas chromatography/mass spectrometry (GC/MS). The semivolatile fraction was obtained by collecting liquid that dripped from the test wheel. The collected material was also analyzed by GC/MS. Both of these analyses were qualitative. The results indicated that in the volatile fraction, the only compounds on the Environmental Protection Agency's (EPA) Superfund List of Analytes detected were contaminants either in the room air or from other potential contamination sources in the laboratory. Similarly, in the semivolatile fraction none of the detected

  18. [Finite element analysis of tooth restored with one-piece of computer aided design and computer aided manufacturing zirconia post-core in three different radiuses].

    Science.gov (United States)

    Zhou, Tuan-feng; Wang, Xin-zhi

    2012-02-18

    To compare the stress distribution of teeth restored with one-piece of computer aided design and computer aided manufacturing (CAD/CAM) zirconia post-cores in three different radiuses. Constructing the 2D finite element models of the standard maxillary central incisal restored by one-piece of CAD/CAM zirconia post-cores and all ceramic crowns, the radius of post was 1.5 mm, 2.0 mm and 2.5 mm respectively. Two tooth root types with or without the ferrule were constructed and there were 6 models in general. Group 1:100 N force loading to the restored teeth through the long axle of teeth and veritical the incisal edge. Group 2: 100 N inclined force loading beneath the incisal edge 2.0 mm by 45° cross the long axle of teeth in the palate side. The stress distribution characteristic of post-cores and teeth roots were analysed. In veritical loading, the stress distribution of one-piece of CAD/CAM zirconia post-core with 2.0 mm radius was better distributed than the two others, The stress concentration of teeth roots locate at the root canal wall where the end of the post exists, which increased with the wider radius of the post-core. In 45° inclined loading, the maximum stress of the zirconia post-core and the teeth root was more than three times of which in vertical loading. In post-cores, the stress concentration was in the labia middle 1/3 of the post. In teeth roots, the stress concentration located at the lateral wall in the post end and the area of the apical foramen. The stress of the post-cores and teeth roots was decreasing in the teeth root with a 2.0 mm ferrule. 2.0 mm radicus of the one-piece of CAD/CAM zirconia post-core is a better choice in clinic. There should be a conical degree in the teeth roots preparing for one-piece of CAD/CAM zirconia post-core restoration. The force of protrusive movement has a greater influence on the post-core and teeth roots. The area of apical may be apt to break in overloading.

  19. KINEMATICS AND DYNAMICS MODELS OF CYLINDRICAL ROLLER BEARING OF RAILWAY TRANSPORT

    Directory of Open Access Journals (Sweden)

    A. V. Gaydamaka

    2014-05-01

    Full Text Available Purpose. Lack of kinematics models and imperfection of the known dynamics models of the roller bearings of railway rolling stock axle-boxes do not allow designing the optimal structure of bearing cages, providing the required service life and reliability of bearing units of wheel sets for cars and locomotives. The studies of kinematics and dynamics of roller bearings of axle boxes for cars and locomotives and modeling of their parts interaction to create the analytical method of bearing cages calculation are necessary. Methodology. This purpose has been achieved due to the modeling of kinematics of the ideal (without gaps and real (taking account the gaps, manufacturing and installation errors bearings, substantiation of the transfer mechanism of motion from the rollers to bearing cage, modeling the dynamics of rolling, research of interaction forces of the rollers with bearing cage. Findings. It is established that the kinematics of ideal bearing is determined by the contact deformations of the rollers and rings, when the kinematics of real bearing depends mainly on the side gaps in the windows of the bearing cage. On the basis of studies of the real bearing kinematics the dynamics models of the rollers and bearing cage interaction were constructed. The conducted studies of kinematics and dynamics of rolling bearings have changed our view of them as of the planetary mechanism, explained the reason of bearing cage loading, and confirmed the possibility of destruction during operation. Originality. It was first proposed a mechanism for motion transfer from the rollers to the bearing cage of roller bearings, consisting in that the side gap in the bearing cage window is reduced gradually multiple of the number of rollers of radial loading area according to the bearing cage motion. The models of roller bearing dynamics, which allow calculating the interaction forces of parts for all modes of operation, were improved. Practical value. Use of the

  20. Properties of train load frequencies and their applications

    Science.gov (United States)

    Milne, D. R. M.; Le Pen, L. M.; Thompson, D. J.; Powrie, W.

    2017-06-01

    A train in motion applies moving steady loads to the railway track as well as dynamic excitation; this causes track deflections, vibration and noise. At low frequency, the spectrum of measured track vibration has been found to have a distinct pattern; with spectral peaks occurring at multiples of the vehicle passing frequency. This pattern can be analysed to quantify aspects of train and track performance as well as to design sensors and systems for trackside condition monitoring. To this end, analytical methods are developed to determine frequency spectra based on known vehicle geometry and track properties. It is shown that the quasi-static wheel loads from a moving train, which are the most significant cause of the track deflections at low frequency, can be understood by considering a loading function representing the train geometry in combination with the response of the track to a single unit load. The Fourier transform of the loading function describes how the passage of repeating vehicles within a train leads to spectral peaks at various multiples of the vehicle passing frequency. When a train consists of a single type of repeating vehicle, these peaks depend on the geometry of that vehicle type as the separation of axles on a bogie and spacing of those bogies on a vehicle cause certain frequencies to be suppressed. Introduction of different vehicle types within a train or coupling of trainsets with a different inter-car length changes the spectrum, although local peaks still occur at multiples of the passing frequency of the primary vehicle. Using data from track-mounted geophones, it is shown that the properties of the train load spectrum, together with a model for track behaviour, allows calculation of the track system support modulus without knowledge of the axle loads, and enables rapid determination of the train speed. For continuous remote condition monitoring, track-mounted transducers are ideally powered using energy harvesting devices. These need

  1. The impact of various distance between axes of worm gear on torque value. Worm gear test stand

    Science.gov (United States)

    Sobek, M.; Baier, A.; Grabowski, Ł.

    2017-08-01

    Transferring both rotational and translational movements in systems used in the automotive industry is a very important and complex issue. In addition, the situation becomes much more difficult and complicated when the design of the transition system requires a high precision of operation as well as a well definite and long operating life. Such requirements are imposed on all components of today’s motor vehicles. However, particular attention is paid to the elements that directly or indirectly affect the safety of persons traveling in the vehicle. Such components are undoubtedly components included as parts of the steering system of the vehicle. Power steering systems have been present in motor vehicles for more than a century. They go through continuous metamorphosis and they are getting better and better. Current power steering systems are based on an electric motor and some kind of transmission. Depending on the position of the drive relative to the steering column, different configurations of the transmission are used. This article will cover issues related to tests of power steering gearing using a worm drive. The worm drive is a very specific example of a propulsion system that uses twisted axles. Normally, in this type of transition you can find two gear units with the axis mounted with a 90° angle between. The components of the worm drive are a worm and a worm gear, also called a worm wheel. In terms of the geometrical form, the worm resembles a helical spur gear. The shape of the worm is similar to the shape of a screw with a trapezoidal thread. A correct matching of these two components ensures proper operation of the entire transmission. Incorrect positioning of the components in relation to each other can significantly reduce the lifetime of the drive unit, and also lead to abnormal work, eg by raising the noise level. This article describes a test method of finding the appropriate distance between the axles of both worm drive units by testing the

  2. Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.

    Science.gov (United States)

    Sivakumar, Smruthy; Lucas, F Anthony San; McDowell, Tina L; Lang, Wenhua; Xu, Li; Fujimoto, Junya; Zhang, Jianjun; Futreal, P Andrew; Fukuoka, Junya; Yatabe, Yasushi; Dubinett, Steven M; Spira, Avrum E; Fowler, Jerry; Hawk, Ernest T; Wistuba, Ignacio I; Scheet, Paul; Kadara, Humam

    2017-11-15

    There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD, and normal tissues. Somatic BRAF variants were found in AAHs from 5 of 22 (23%) patients, 4 of 5 of whom had matched LUAD with driver EGFR mutations. KRAS mutations were present in AAHs from 4 of 22 (18%) of patients. KRAS mutations in AAH were only found in ever-smokers and were exclusive to BRAF -mutant cases. Integrative analysis revealed profiles expressed in KRAS -mutant cases ( UBE2C, REL ) and BRAF -mutant cases ( MAX ) of AAH, or common to both sets of cases (suppressed AXL ). Gene sets associated with suppressed antitumor (Th1; IL12A, GZMB ) and elevated protumor ( CCR2, CTLA-4 ) immune signaling were enriched in AAH development and progression. Our results reveal potentially divergent BRAF or KRAS pathways in AAH as well as immune dysregulation in the pathogenesis of this premalignant lung lesion. Cancer Res; 77(22); 6119-30. ©2017 AACR . ©2017 American Association for Cancer Research.

  3. Stress-based fatigue reliability analysis ofthe rail fastening spring clipunder traffic loads

    Directory of Open Access Journals (Sweden)

    Saeed Mohammadzadeh

    Full Text Available Nowadays, the rail fastening systems play an important role for preserving the connection between the rails and sleepers in various conditions. In this paper, stress based concept is used to develop a comprehensive approach for fatigue reliability analysisof fastening spring clip. Axle load, speed and material properties are assumed to be random variables. First, track and train models are analyzed dynamically in order to achieve displacement time history of fas-tening spring clip. Then this displacement time history is applied to the fastening spring clip in FE software to obtain variable ampli-tude of stresses. Crack nucleation life is calculated by rain-flow method and Palmgren-Miner linear damage rule. First Order Relia-bility Method (FORM and Monte-Carlosimulation technique are employed for the reliability index estimations. The influences of various random variables on the probability of failure are investi-gated by sensitivity analysis. The results show that the equivalent stress range and material parameter have significant effect on fa-tigue crack nucleation.

  4. Use of audiovisual resources in a FlexQuest strategy on Radioactivity

    Directory of Open Access Journals (Sweden)

    Flávia Cristina Gomes Catunda de Vasconcelos

    2012-03-01

    Full Text Available This paper presents a study conducted in a private school in Recife - PE, Brazil, with 25 students from 1st year of high school. One of the focuses was to evaluate the implementation of the strategy FlexQuest on the teaching of radioactivity. The FlexQuest incorporates, within the WebQuest, the Cognitive Flexibility Theory (TFC, which is a theory of teaching, learning and knowledge representation, aiming to propose strategies for the acquisition of advanced levels of knowledge. With a qualitative approach, there were interventions of application having, as axle, an analysis of landscape crossings that the students have accomplished during the execution of required tasks. The results revealed that this strategy involves audiovisual resources, and these make learning possible, provided that strategies are embedded in a constructivist approach to teaching and learning. In this sense, it was perceived to be effective, the introductory level/stimulator, for the understanding of the applications of radioactivity. Showing a tool based on real situations, enabling students to develop the critical eye on what it is televised, including also the study of radioactivity.

  5. AN ALTERNATIVE MODEL FOR OPTIMISING PAYLOADS OF BUILDING GLASS

    Directory of Open Access Journals (Sweden)

    H.A. Taha

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: This article deals with the development of a multi-stage model for optimising payload placement on a hauler-trailer rig in an environment described by physical and regulatory constraints. The model which purports to be an improvement on an earlier model provides two types of solution i.e. a feasible solution which satisfies all zone loading and axle weight constraints, or an infeasible solution giving the cause and quantification of source(s of infeasibility which may be used to modify model inputs for further attempts at optimisation.

    AFRIKAANSE OPSOMMING: Die artikel handel oor die ontwikkeling van 'n multistadiummodel vir die optimisering van vragplasing op 'n sleepwa onder fisiese en regsvoorskriftelike voorwaardes. Die model wat daarop aanspraak maak dat dit 'n verbetering is op 'n vorige model, lewer as uitset twee oplossingstipes naamlik 'n gangbare oplossing wat alle sone- en aslasrandvoorwaardes eerbiedig, of 'n ongangbare oplossing wat oorsaak en kwantifisering van ongangbaarheidsbronne uitwys vir die gebruik van gewysigde modelinsette by verdere pogings tot optimisering.

  6. The TAM receptor Tyro3 regulates myelination in the central nervous system.

    Science.gov (United States)

    Akkermann, Rainer; Aprico, Andrea; Perera, Ashwyn A; Bujalka, Helena; Cole, Alistair E; Xiao, Junhua; Field, Judith; Kilpatrick, Trevor J; Binder, Michele D

    2017-04-01

    Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction of electrical impulses by axons, as well as providing trophic support to neurons. Within the central nervous system, the oligodendrocyte is the specialized neural cell responsible for producing myelin by a process that is thought to be regulated by both activity dependent and independent mechanisms but in incompletely understood ways. We have previously identified that the protein Gas6, a ligand for a family of tyrosine kinase receptors known as the TAM (Tyro3, Axl, and Mertk) receptors, directly increases oligodendrocyte induced myelination in vitro. Gas6 can bind to and activate all three TAM receptors, but the high level of expression of Tyro3 on oligodendrocytes makes this receptor the principal candidate for transducing the pro-myelinating effect of Gas6. In this study, we establish that in the absence of Tyro3, the pro-myelinating effect of Gas6 is lost, that developmental myelination is delayed and that the myelin produced is thinner than normal. We show that this effect is specific to the myelination process and not due to changes in the proliferation or differentiation of oligodendrocyte precursor cells. We have further demonstrated that the reduction in myelination is due to the loss of Tyro3 on oligodendrocytes, and this effect may be mediated by activation of Erk1. Collectively, our findings indicate the critical importance of Tyro3 in potentiating central nervous system myelination. GLIA 2017 GLIA 2017;65:581-591. © 2017 Wiley Periodicals, Inc.

  7. Implementation of an RFID-Based Sequencing-Error-Proofing System for Automotive Manufacturing Logistics

    Directory of Open Access Journals (Sweden)

    Yong-Shin Kang

    2018-01-01

    Full Text Available Serialized tracing provides the ability to track and trace the lifecycle of the products and parts. Unlike barcodes, Radio frequency identification (RFID, which is an important building block for internet of things (IoT, does not require a line of sight and has the advantages of recognizing many objects simultaneously and rapidly, and storing more information than barcodes. Therefore, RFID has been used in a variety of application domains such as logistics, distributions, and manufacturing, significantly improving traceability and process efficiency. In this study, we applied RFID to improve the just-in-sequence operation of an automotive inbound logistics process. First, we implemented an RFID-based visibility system for real-time traceability and control of part supply from the production lines of suppliers to the assembly line of a car manufacturer. Second, we developed an RFID-based sequence-error proofing system to avoid accidental line stops due to incorrect part sequencing. The whole system has been successfully installed in a rear-axle inbound logistics process of GM Korea. We achieved a significant amount of cost savings, especially due to the prevention of sequencing errors and part shortages, and the reduction of manual operations. Thorough cost-benefit analysis demonstrates the clear economic feasibility of using RFID technologies for the just-in-sequence inbound logistics in an automobile manufacturing environment.

  8. Condutivity effect in electro-coagulation-flotation applied to physico-chemical wastewater treatment

    Directory of Open Access Journals (Sweden)

    Francisco Javier Cuba Terán

    2007-03-01

    Full Text Available This study reports on the effect of conductivity on the simultaneous applicability of water electrolysis , chemical coagulation and flotation fundamentals in the treatment of wastewater with large amounts of suspended matter, characterizing electro-coagulation-flotation (ECF . Results from experiments carried out in a pilot study implanted and operated in the Laboratory of Environment Control (LCA, at the State University of Campinas in Limeira are presented. ECF was developed in an electrolytic reactor where water passed through aluminum electrodes connected to a power supply. Electrochemical reactions promoted Al3+ ions emission from anode, neutralizing repulsive pollutant forces, forming flakes. An evolution of micro hydrogen bubbles occurred, carrying the flakes to the top of the solution, causing flotation and polluter removal. System monitoring aimed at reaching optimal operation conditions regarding time of liquid permanence in the reactor, influence of the NaC1 addition on the increase of affluent conductivity, and influence of polarity inversion over cathodic passivation. Results from carwash wastewater treatment reported 86% efficiency rate for color, 90,15% for turbidity and 85,43% for oil and axle-grease removal.

  9. Drawbar Pull and Its Effect on the Weight Distribution of a Tractor

    Directory of Open Access Journals (Sweden)

    Adam Polcar

    2017-01-01

    Full Text Available This article aims to experimentally determine how the tractor’s weight distribution changes during loading by drawbar pull, and how the tractor’s weight affects its drawbar pull properties. Drive wheel ballasting has a significant effect on the drawbar pull and wheel slip of the tractor - travelling gear losses. To achieve these objectives, we conducted experimental measurements on the tractor Case IH Magnum 370 CVX. The results show that higher drawbar pull is achieved in tractors with a higher weight. The measured increase of drawbar pull was 15,8 kN between maximal and minimal weight (∆ 2320 kg. All variants show an equal percentage increase in the weight on the rear axle of the tractor (+ 6 %. Increasing the tractor’s weight affected the drawbar pull as well as the wheel slip. As the tractor’s weight increases, there is a smaller increase in wheel slip as the drawbar pull increases. The results confirmed that tractor ballasting is important in order to achieve optimum drawbar pull properties, but it is necessary to keep in mind that the higher the weight of the machine or equipment, the larger the effect on the soil.

  10. Development of Estimation Force Feedback Torque Control Algorithm for Driver Steering Feel in Vehicle Steer by Wire System: Hardware in the Loop

    Directory of Open Access Journals (Sweden)

    Sheikh Muhammad Hafiz Fahami

    2015-01-01

    Full Text Available In conventional steering system, a feedback torque is produced from the contact between tire and road surface and its flows through mechanical column shaft directly to driver. This allows the driver to sense the steering feel during driving. However, in steer by wire (SBW system, the elimination of the mechanical column shaft requires the system to generate the feedback torque which should produce similar performance with conventional steering system. Therefore, this paper proposes a control algorithm to create the force feedback torque for SBW system. The direct current measurement approach is used to estimate torque at the steering wheel and front axle motor as elements to the feedback torque, while, adding the compensation torque for a realistic feedback torque. The gain scheduling with a linear quadratic regulator controller is used to control the feedback torque and to vary a steering feel gain. To investigate the effectiveness of the proposed algorithm, a real-time hardware in the loop (HIL methodology is developed using Matlab XPC target toolbox. The results show that the proposed algorithm is able to generate the feedback torque similar to EPS steering system. Furthermore, the compensation torque is able to improve the steering feel and stabilize the system.

  11. NASA Tech Briefs, September 2003

    Science.gov (United States)

    2003-01-01

    Topics include: Oxygen-Partial-Pressure Sensor for Aircraft Oxygen Mask; Three-Dimensional Venturi Sensor for Measuring Extreme Winds; Swarms of Micron-Sized Sensors; Monitoring Volcanoes by Use of Air-Dropped Sensor Packages; Capacitive Sensors for Measuring Masses of Cryogenic Fluids; UHF Microstrip Antenna Array for Synthetic- Aperture Radar; Multimode Broad-Band Patch Antennas; 164-GHz MMIC HEMT Frequency Doubler; GPS Position and Heading Circuitry for Ships; Software for Managing Parametric Studies; Software Aids Visualization of Computed Unsteady Flow; Software for Testing Electroactive Structural Components; Advanced Software for Analysis of High-Speed Rolling-Element Bearings; Web Program for Development of GUIs for Cluster Computers; XML-Based Generator of C++ Code for Integration With GUIs; Oxide Protective Coats for Ir/Re Rocket Combustion Chambers; Simplified Waterproofing of Aerogels; Improved Thermal-Insulation Systems for Low Temperatures; Device for Automated Cutting and Transfer of Plant Shoots; Extension of Liouville Formalism to Postinstability Dynamics; Advances in Thrust-Based Emergency Control of an Airplane; Ultrasonic/Sonic Mechanisms for Drilling and Coring; Exercise Device Would Exert Selectable Constant Resistance; Improved Apparatus for Measuring Distance Between Axles; Six Classes of Diffraction-Based Optoelectronic Instruments; Modernizing Fortran 77 Legacy Codes; Active State Model for Autonomous Systems; Shields for Enhanced Protection Against High-Speed Debris; Scaling of Two-Phase Flows to Partial-Earth Gravity; Neutral-Axis Springs for Thin-Wall Integral Boom Hinges.

  12. O novo perfil econômico do Grande ABC

    Directory of Open Access Journals (Sweden)

    Juliana Pedreschi Rodrigues

    2007-06-01

    Full Text Available Este artigo trata de questões referentes às mudanças econômicas e urbanas na região do Grande ABC. Para tanto, inicialmente, apresentamos dados sobre a implantação da indústria automobilística e o desenvolvimento urbano decorrente dessas mudanças, bem como a composição da força de trabalho vinda de outros Estados do país. A partir da reestruturação econômica ocorrida na região, surgem as parcerias público-privadas estabelecidas para a criação de Arranjos Produtivos Locais (APLs, e as alternativas de recuperação por meio da criação do Eixo Tamanduatehy Axle também são analisadas. Concluímos com uma abordagem sobre a reestruturação econômica da região, considerando especialmente os pólos industriais e os arranjos produtivos locais, os quais agrupam organizações de variados segmentos econômicos, bem como a formação da Agência de Desenvolvimento Regional.

  13. 21. century drilling rigs -- Tesco introduces new modular design

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1998-10-01

    Development of a modular, hydraulic, self-elevating drilling rig, dubbed the `21. century drilling rig` was announced by the Tesco Corporation. The rig equipment is housed in 8 by 20 by 8.5 feet high sea containers that can be handled by a 20-ton oilfield picker. These containers, weighing about 15,000 to 20,000 pounds on average, eliminate the need for heavy and bulky standard oilfield skid buildings, besides avoiding costly over-width and over-weight permits. The containers can be easily shipped around the world at a fraction of the cost of shipping standard oilfield skid buildings. Time for shipping on land is comparable to conventional rigs, but with the added advantage of smaller and lighter loads, promising fewer transportation problems during spring breakup. Tesco also designed and built an 85-foot long, triple-axle, 24-wheel catwalk trailer to transport the top drive, drawworks and double telescoping mast as one unit. Another novel characteristic of this unit is that the hydraulic system is capable of selectable distribution of power to the main functions such as the top drive, drawworks, or mud pump, similar to the electric SCR rig. The rig also features a computerized control system managed by programmable logic controllers. The split crown and split block to facilitate wireline work, are other innovative features worthy of note.

  14. Vehicle dynamic effects in the course of passing over turnouts

    Directory of Open Access Journals (Sweden)

    Zelenka J.

    2007-11-01

    Full Text Available For the quantification of vehicle dynamic effects at passing over turnouts at a higher speed there was developed a methodology for evaluating of acceleration measured on vehicle axle boxes in the year 2003. The methodology is based on statistical evaluation of lateral and vertical acceleration measured values at passing over both critical parts of a turnout (tongue, frog. The created methodology was used for investigation of vehicle dynamic effects by running at speed up to 230 km/h in the year 2004 in terms of high speed tests of tilting-body unit class 680 CD. There was found relatively high values of dynamic effects already at a speed 160 km/h. In terms of tilting-body unit class 680 tests at a higher speed in curves of chosen track lines of 1st and 2nd corridor of Czech Railways there was carried out also verification of curved turnouts state according to methodology mentioned above with a view to possibility of speed increasing at curved throats of chosen stations. Lateral vehicle dynamic effects at passing over a curved turnout frog area were evaluated. There were carried out simulation calculations of vehicle passing over a turnout based on measured geometric parameters of wheelset as well as chosen turnouts. Results of the calculations were compared with measurements. The increased vehicle dynamic effects found in pulsed beats character influence negatively the turnouts part (not only wheel contacting parts as well as operating life all unsuspended parts of vehicles.

  15. The IMO-1 mobile irradiation unit

    International Nuclear Information System (INIS)

    Cancio, Ruben; Gomez, Aristobulo; Mugliaroli, Hugo.

    1976-07-01

    The IMO-I is made up by a gamma irradiation bucket and a fixed source, mounted on a trailer specially designed. This equipment has been completed with a radiocomunication device. The irradiator unit consist of two fixed and one movable body. The irradiation bucket has a volume of 30 x 40 x 30 cm and is moved through an hydraulic system with allows its vertical movement between the upper or charging position and the bottom or irradiation position. The telecontrol device has been installed in the room contiguous to the irradiator. The conventional industrial sources of Co 60 , are vertically located in stainless steel source holders at the botton fixed body and they can be changed according with the desired geometry. The trailer has been built over a plain chassis assembled structure with a double axle at the rear. It consists of two rooms, one for the irradiator machine and the other one for the telecontrol device and the radiocomunication facility. (author) [es

  16. Delta 9-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18

    Directory of Open Access Journals (Sweden)

    Douglas eMcHugh

    2014-01-01

    Full Text Available Microglial cells are extremely plastic and undergo a variety of CNS-prompted shape changes relative to their location and current role. Signaling molecules from neurons also regulate microglial cytokine production. Neurons are known to employ the endogenous cannabinoid system to communicate with other cells of the CNS. N-arachidonoyl glycine (NAGly and Δ9-tetrahydrocannabinol (Δ9-THC signaling via GPR18 has been introduced as an important new target in microglial-neuronal communication. Our hypothesis is that endogenous NAGly-GPR18 signaling regulates phenotypic shape and cytokine production in microglia, and is mimicked by Δ9-THC in the BV-2 microglia model system. BV-2 microglia were exposed to NAGly and Δ9-THC or Vh for 12 hours, which resulted in significant differences in the cell morphologies expressed. Cannabidiol (CBD was effective at antagonizing the effects of both NAGly and Δ9-THC. Using ELISA-based microarrays, BV-2 microglia were exposed to NAGly and Δ9-THC or Vh for 3 hours and the presence of 40 cytokines in the culture media quantified. Production of Axl, CD40, IGF-I, OPN and Pro-MMP-9 were significantly altered by NAGly and Δ9-THC, and antagonized by CBD. These data add to an emerging profile that emphasizes NAGly as a component of an endogenous system present in the CNS that tightly integrates microglial proliferation, recruitment and adhesion with neuron-glia interactivity and tissue remodeling.

  17. DNA Methylation and Gene Expression Profiling of Ewing Sarcoma Primary Tumors Reveal Genes That Are Potential Targets of Epigenetic Inactivation

    Directory of Open Access Journals (Sweden)

    Nikul Patel

    2012-01-01

    Full Text Available The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded EWS tumors and 3 EWS cell lines was compared to human mesenchymal stem cell primary cultures (hMSCs using bead chip methylation analysis. Relative expression of methylated genes was assessed in 5-Aza-2-deoxycytidine-(5-AZA-treated EWS cell lines and in a cohort of primary EWS samples and hMSCs by gene expression and quantitative RT-PCR. 129 genes demonstrated statistically significant hypermethylation in EWS tumors compared to hMSCs. Thirty-six genes were profoundly methylated in EWS and unmethylated in hMSCs. 5-AZA treatment of EWS cell lines resulted in upregulation of expression of hundreds of genes including 162 that were increased by at least 2-fold. The expression of 19 of 36 candidate hypermethylated genes was increased following 5-AZA. Analysis of gene expression from an independent cohort of tumors confirmed decreased expression of six of nineteen hypermethylated genes (AXL, COL1A1, CYP1B1, LYN, SERPINE1, and VCAN. Comparing gene expression and DNA methylation analyses proved to be an effective way to identify genes epigenetically regulated in EWS. Further investigation is ongoing to elucidate the role of these epigenetic alterations in EWS pathogenesis.

  18. Logistic platform: an alternative to the logistic activities development in Macae (Rio de Janeiro, Brazil); Plataforma logistica: uma alternativa ao desenvolvimento das atividades logisticas em Macae (Rio de Janeiro, Brasil)

    Energy Technology Data Exchange (ETDEWEB)

    Simas, Francisco A.M. [C. Foster Servicos e Equipamentos de Petroleo Ltda., Macae, RJ (Brazil); Esteves, Luis Sergio N.; Jesus, Jonas David [Universidade Estacio de Sa, Macae, RJ (Brazil); Pedroso, Luiz Lucio A. [Halliburton Servicos Ltda., Macae, RJ (Brazil); Santana, Winston [Sistema FIRJAN, Macae, RJ (Brazil); Aguiar, David B. de [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Geociencias. Programa de Pos-Graduacao em Ciencia Ambiental - PGCA

    2004-07-01

    Considering the importance of the system of supplying in attendance to the necessities demanded in the petroliferous sector inside of the norms and regulations established for the competent agencies in the country, the present work if considers to present a project of creation of a Logistic Platform as an alternative for the development of the logistic activities in Macae, creating a port infrastructure, aiming at the Also available optimization of the modal ones of transport in the region, with installation of one customs politics that makes possible the load, discharge and storage of parts, equipment and feedstocks, creating partnerships in the development and implantation of software that they speed the logistic system of the sector offshore, thus promoting, an improvement in the offered services the customer, reducing costs and increasing the productivity and globalization of the market, led for the agreement that Macae makes use of the main necessary requirements to its development for possessing the main modal axles of transport as alternative of circulation of merchandises and equipment favorable to the implantation of a Logistic Platform. (author)

  19. Output characteristics of floating type wave power generator system using a ball screw; Fuyugata nejishiki haryoku hatsuden sochi no shutsuryoku tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Abe, T.; Omata, K. [Meiji University, Tokyo (Japan)

    1996-10-27

    A floating type wave power generator system using a ball screw is proposed. Output characteristics are simulated on the supposition of its employment aboard a navigational aid buoy. The relative linear movement produced by waves between the main body and float is transmitted via a load column to a ball nut and is converted into a rotary movement of a threaded shaft engaging the ball nut. Attached to the bottom end of the threaded shaft is a one-way clutch which connects to the generator axle when the relative velocity between the float and main body is positive. The simulation was conducted for a wave activated power generation buoy, 2.6m in outer diameter, 4.5m in length, and 6000kg in total mass. The buoy generated a mechanical output of 340kW when exposed to a sinusoidal wave 2.5 seconds in period and 40cm in wave height. A tank test was performed using a reduced scale model consisting of a ball screw, bicycle dynamo, and float, with the main body being 318mm in diameter and 833mm in length, when an average output of 4.51W was obtained at 60% efficiency. The results of the experiment agreed in some degree with the results of calculation, verifying the righteousness of the theoretical formula. 3 refs., 7 figs., 4 tabs.

  20. AC propulsion system for an electric vehicle, phase 2

    Science.gov (United States)

    Slicker, J. M.

    1983-01-01

    A second-generation prototype ac propulsion system for a passenger electric vehicle was designed, fabricated, tested, installed in a modified Mercury Lynx vehicle and track tested at the Contractor's site. The system consisted of a Phase 2, 18.7 kw rated ac induction traction motor, a 192-volt, battery powered, pulse-width-modulated, transistorized inverter packaged for under rear seat installation, a 2-axis, 2-speed, automatically-shifted mechanical transaxle and a microprocessor-based powertrain/vehicle controller. A diagnostics computer to assist tuning and fault finding was fabricated. Dc-to-mechanical-system efficiency varied from 78% to 82% as axle speed/torque ranged from 159 rpm/788 nm to 65 rpm/328 nm. Track test efficiency results suggest that the ac system will be equal or superior to dc systems when driving urban cycles. Additional short-term work is being performed under a third contract phase (AC-3) to raise transaxle efficiency to predicted levels, and to improve starting and shifting characteristics. However, the long-term challenge to the system's viability remains inverter cost. A final report on the Phase 2 system, describing Phase 3 modifications, will be issued at the conclusion of AC-3.

  1. Optimal Design of an Axial-Flux Permanent-Magnet Middle Motor Integrated in a Cycloidal Reducer for a Pedal Electric Cycle

    Directory of Open Access Journals (Sweden)

    Yee-Pien Yang

    2015-12-01

    Full Text Available This paper proposes an optimal design of a middle motor integrated into a mid-drive unit for pedal electric cycles. This middle motor is an axial-flux permanent magnet brushless DC motor with a stator plate. Facing this plate is a rotor plate that acts as an eccentric component of a cycloidal reducer next to the stator. Both the middle motor and cycloidal reducer are easily installed on the same axle of the bike crankset. In the preliminary design, driving requirements are used to make the middle motor specifications. The numbers of stator slots and magnet poles on the rotor were chosen to achieve the best winding factor, and the winding layout was determined accordingly. A one-dimensional magnetic circuit model of the middle motor was built, and its shape was optimized utilizing a multifunctional optimization system tool. Finally, the resulting design was verified and refined by a finite element analysis. A prototype of the middle motor was fabricated with a stator made of a soft magnetic composite and integrated with a cycloidal reducer. Experimental results show that the motor has a sinusoidal back electromotive force. Additionally, it is easily controlled by sinusoidal currents with acceptable torque and speed curves.

  2. Vibration immission forecast by means of train equivalent synthetic vibration experiments

    Directory of Open Access Journals (Sweden)

    Steinhauser Peter

    2015-01-01

    Full Text Available Vibration abatement measures at a railway track require forecasts before the rails are put into place. Due to the multiple feedback system between train, track, geodynamics of the local underground and the dynamic behavior of the neighbourhood buildings these prognoses become very elaborate. All the parameters of the dynamic system scatter extremely as the results from numerous investigations prove. This concerns vibration emission spectra, tunnel mobility, geodynamic vibration loss along the transfer through the underground as well as the natural frequencies from buildings and ceilings. Therefore experimental in-situ investigations are indispensable for trustworthy forecasts. In this paper the VibroScan method is presented, whose basic idea is to implement the principle of equivalence between the synthetic vibrations used for the experiments and train vibration emissions at the highest possible degree. This is focused on emission spectra, force of excitation, unsprung wheelset mass and axle load. The necessary experimental provisions are discussed and some examples of results are given like the protection of the Musikverein building in Vienna or the Sagrada Familia basilica in Barcelona against vibrations from tunnels in the immediate neighbourhood.

  3. Adjustment mechanism

    International Nuclear Information System (INIS)

    1978-01-01

    Mechanism for the variation of the underlying support of a pick-up with a measuring crystal in particular for the application to an X-ray spectrometer, whereby the crystal is placed on a rotatable axle and the pick-up is placed on an arm of a circular track around the axis of the crystal, whereby the crystal axis and the pick-up arm are coupled so that the rotation of the crystal axis and the pickup arm are coupled so that the rotation of the crystal axis over an angle theta is paired with the rotation of the pick-up arm of an angle two-theta, characterised in that around the crystal axis is fixed a first disc with a radius r and wherein a second disc with a radius 2r is superimposed, whereby a mechanism further comprises two guide rollers over each of which a tape or wire is laid whereby each of the tapes is fixed at one end of the first disc and at the other end to the second disc. (G.C.)

  4. Finite Element Analysis for Fatigue Damage Reduction in Metallic Riveted Bridges Using Pre-Stressed CFRP Plates

    Directory of Open Access Journals (Sweden)

    Elyas Ghafoori

    2014-04-01

    Full Text Available Many old riveted steel bridges remain operational and require retrofit to accommodate ever increasing demands. Complicating retrofit efforts, riveted steel bridges are often considered historical structures where structural modifications that affect the original construction are to be avoided. The presence of rivets along with preservation requirements often prevent the use of traditional retrofit methods, such as bonding of fiber reinforced composites, or the addition of supplementary steel elements. In this paper, an un-bonded post-tensioning retrofit method is numerically investigated using existing railway riveted bridge geometry in Switzerland. The finite element (FE model consists of a global dynamic model for the whole bridge and a more refined sub-model for a riveted joint. The FE model results include dynamic effects from axle loads and are compared with field measurements. Pre-stressed un-bonded carbon fiber reinforced plastic (CFRP plates will be considered for the strengthening elements. Fatigue critical regions of the bridge are identified, and the effects of the un-bonded post-tensioning method with different pre-stress levels on fatigue susceptibility are explored. With an applied 40% CFRP pre-stress, fatigue damage reductions of more than 87% and 85% are achieved at the longitudinal-to-cross beam connections and cross-beam bottom flanges, respectively.

  5. The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.

    Science.gov (United States)

    Lee, Baeck-seung; Dekker, Joseph D; Lee, Bum-kyu; Iyer, Vishwanath R; Sleckman, Barry P; Shaffer, Arthur L; Ippolito, Gregory C; Tucker, Philip W

    2013-05-01

    Recombination-activating gene 1 protein (RAG1) and RAG2 are critical enzymes for initiating variable-diversity-joining (VDJ) segment recombination, an essential process for antigen receptor expression and lymphocyte development. The transcription factor BCL11A is required for B cell development, but its molecular function(s) in B cell fate specification and commitment is unknown. We show here that the major B cell isoform, BCL11A-XL, binds the RAG1 promoter and Erag enhancer to activate RAG1 and RAG2 transcription in pre-B cells. We employed BCL11A overexpression with recombination substrates in a cultured pre-B cell line as well as Cre recombinase-mediated Bcl11a(lox/lox) deletion in explanted murine pre-B cells to demonstrate direct consequences of BCL11A/RAG modulation on V(D)J recombination. We conclude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by controlling V(D)J recombination.

  6. Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming.

    Science.gov (United States)

    Lumbroso, Delphine; Soboh, Soaad; Maimon, Avi; Schif-Zuck, Sagie; Ariel, Amiram; Burstyn-Cohen, Tal

    2018-01-01

    The complete resolution of inflammation requires the uptake of apoptotic polymorphonuclear cells (PMN) by local macrophages (efferocytosis) and the consequent reprogramming of the engulfing phagocytes to reparative and pro-resolving phenotypes. The tyrosine kinase receptors TYRO3, AXL, and MERTK (collectively named TAM) are fundamental mediators in regulating inflammatory responses and efferocytosis. Protein S (PROS1) is a ligand for all TAM receptors that mediates various aspects of their activity. However, the involvement of PROS1 in the resolution of inflammation is incompletely understood. Here, we report the upregulation of Pros1 in macrophages during the resolution of inflammation. Selective knockout of Pros1 in the myeloid lineage significantly downregulated macrophage pro-resolving properties. Hence, Pros1 -deficient macrophages engulfed fewer apoptotic PMN remnants in vivo , and exogenous PROS1 rescued impaired efferocytosis ex vivo . Moreover, Pros1 -deficient peritoneal macrophages secreted higher levels of the pro-inflammatory mediators TNFα and CCL3, while they secreted lower levels of the reparative/anti-inflammatory IL-10 following exposure to lipopolysaccharide in comparison to their WT counterparts. Moreover, Pros1 -deficient macrophages expressed less of the anti-inflammatory/pro-resolving enzymes arginase-1 and 12/15-lipoxygenase and produced less of the specialized pro-resolving mediator resolvin D1. Altogether, our results suggest that macrophage-derived PROS1 is an important effector molecule in regulating the efferocytosis, maturation, and reprogramming of resolution phase macrophages, and imply that PROS1 could provide a new therapeutic target for inflammatory and fibrotic disorders.

  7. Vibration Study of Fork-lift Truck Based on the Virtual Prototype Technology

    Directory of Open Access Journals (Sweden)

    YANG Mingliang

    2014-05-01

    Full Text Available The forklift truck is one of important equipments of the modern logistics system. As the forklift truck is running, the driver seat and steering wheel of a certain type of fork-lift truck vibrate strongly, virtual prototyping technology and multi-body dynamics are used to make simulation of dynamic performance of fork-lift truck in this paper, and then the test result is compared with time course load that obtained from frame junction with the annex. We should repeatedly modify the simulation model based on test results, which is consistent with the actual results. Based on this model, so we put forward measures for improving design: Firstly, the axis of rotation of oval steering axle is implied; Secondly, the overhead guard is connected with the frame by the rubber cushion blocks at four different locations; Thirdly, the engine is fixed on the frame by the rubber cushion blocks (shock mount in two different position. The improved simulation and experimental verification are carried out under the same conditions, and the results show that the fundamental frequency of seat of the improved fork-lift truck and vibration energy are lower. The result proves the practical value of this method in the research of the vibration characteristics of complete engineering machine.

  8. Performance Deterioration of Heavy-Haul Railway Bridges under Fatigue Loading Monitored by a Multisensor System

    Directory of Open Access Journals (Sweden)

    Zhiwu Yu

    2018-01-01

    Full Text Available Heavy-haul railway bridges play an increasingly essential role in the transportation in China due to the increasing transport volume. The performance deterioration of the scale models of a typical heavy-haul railway bridge under fatigue loading is monitored in this work, based on a multisensor system including the fiber-reinforced polymer optical fiber Bragg grating and electrical resistance strain gauges, linear variable displacement transducer, and accelerometer. Specifically, by monitoring/observing on the failure mode, fatigue life, load-midspan deflection response, material strain development, and so forth, this work develops an S-N model by comparing the relationship between fatigue life and rebar stress range with that between fatigue life and load level and proposes a damage evolution model considering the coupling of the stiffness degradation and inelastic deformation of specimens. It is found that the fatigue life of specimens is determined by the fatigue life of the rebar at the bottom and it may be lower than 2.0 million cycles with a 30-ton axle weight when environmental factors are taken into account. The predictions of the models agree well with experimental results. Therefore, this work furthers the understanding of the fatigue performance deterioration of the bridges by using a multisensor system.

  9. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia

    Directory of Open Access Journals (Sweden)

    Hongqi Liu

    2017-02-01

    Full Text Available Genetic S6K1 inactivation can induce apoptosis in PTEN-deficient cells. We analyzed the therapeutic potential of S6K1 inhibitors in PTEN-deficient T cell leukemia and glioblastoma. Results revealed that the S6K1 inhibitor LY-2779964 was relatively ineffective as a single agent, while S6K1-targeting AD80 induced cytotoxicity selectively in PTEN-deficient cells. In vivo, AD80 rescued 50% of mice transplanted with PTEN-deficient leukemia cells. Cells surviving LY-2779964 treatment exhibited inhibitor-induced S6K1 phosphorylation due to increased mTOR-S6K1 co-association, which primed the rapid recovery of S6K1 signaling. In contrast, AD80 avoided S6K1 phosphorylation and mTOR co-association, resulting in durable suppression of S6K1-induced signaling and protein synthesis. Kinome analysis revealed that AD80 coordinately inhibits S6K1 together with the TAM family tyrosine kinase AXL. TAM suppression by BMS-777607 or genetic knockdown potentiated cytotoxic responses to LY-2779964 in PTEN-deficient glioblastoma cells. These results reveal that combination targeting of S6K1 and TAMs is a potential strategy for treatment of PTEN-deficient malignancy.

  10. Study on development system of increasing gearbox for high-performance wind-power generator

    Science.gov (United States)

    Xu, Hongbin; Yan, Kejun; Zhao, Junyu

    2005-12-01

    Based on the analysis of the development potentiality of wind-power generator and domestic manufacture of its key parts in China, an independent development system of the Increasing Gearbox for High-performance Wind-power Generator (IGHPWG) was introduced. The main elements of the system were studied, including the procedure design, design analysis system, manufacturing technology and detecting system, and the relative important technologies were analyzed such as mixed optimal joint transmission structure of the first planetary drive with two grade parallel axle drive based on equal strength, tooth root round cutting technology before milling hard tooth surface, high-precise tooth grinding technology, heat treatment optimal technology and complex surface technique, and rig test and detection technique of IGHPWG. The development conception was advanced the data share and quality assurance system through all the elements of the development system. The increasing Gearboxes for 600KW and 1MW Wind-power Generator have been successfully developed through the application of the development system.

  11. Stability and optimised H∞ control of tripped and untripped vehicle rollover

    Science.gov (United States)

    Jin, Zhilin; Zhang, Lei; Zhang, Jiale; Khajepour, Amir

    2016-10-01

    Vehicle rollover is a serious traffic accident. In order to accurately evaluate the possibility of untripped and some special tripped vehicle rollovers, and to prevent vehicle rollover under unpredictable variations of parameters and harsh driving conditions, a new rollover index and an anti-roll control strategy are proposed in this paper. Taking deflections of steering and suspension induced by the roll at the axles into consideration, a six degrees of freedom dynamic model is established, including lateral, yaw, roll, and vertical motions of sprung and unsprung masses. From the vehicle dynamics theory, a new rollover index is developed to predict vehicle rollover risk under both untripped and special tripped situations. This new rollover index is validated by Carsim simulations. In addition, an H-infinity controller with electro hydraulic brake system is optimised by genetic algorithm to improve the anti-rollover performance of the vehicle. The stability and robustness of the active rollover prevention control system are analysed by some numerical simulations. The results show that the control system can improve the critical speed of vehicle rollover obviously, and has a good robustness for variations in the number of passengers and longitude position of the centre of gravity.

  12. The response of a high-speed train wheel to a harmonic wheel-rail force

    International Nuclear Information System (INIS)

    Sheng, Xiaozhen; Liu, Yuxia; Zhou, Xin

    2016-01-01

    The maximum speed of China's high-speed trains currently is 300km/h and expected to increase to 350-400km/h. As a wheel travels along the rail at such a high speed, it is subject to a force rotating at the same speed along its periphery. This fast moving force contains not only the axle load component, but also many components of high frequencies generated from wheel-rail interactions. Rotation of the wheel also introduces centrifugal and gyroscopic effects. How the wheel responds is fundamental to many issues, including wheel-rail contact, traction, wear and noise. In this paper, by making use of its axial symmetry, a special finite element scheme is developed for responses of a train wheel subject to a vertical and harmonic wheel-rail force. This FE scheme only requires a 2D mesh over a cross-section containing the wheel axis but includes all the effects induced by wheel rotation. Nodal displacements, as a periodic function of the cross-section angle 6, can be decomposed, using Fourier series, into a number of components at different circumferential orders. The derived FE equation is solved for each circumferential order. The sum of responses at all circumferential orders gives the actual response of the wheel. (paper)

  13. Child and family safety device affordability by country income level: an 18 country comparison.

    Science.gov (United States)

    Hendrie, D; Miller, T R; Orlando, M; Spicer, R S; Taft, C; Consunji, R; Zaloshnja, E

    2004-12-01

    To compare availability, urban price, and affordability of child/family safety devices between 18 economically diverse countries. Descriptive: urban price surveys by local safety organisations or shoppers. Retail stores and internet vendors. Prices expressed in US dollars, and affordability measured by hours of factory work needed to buy a child safety seat, a belt-positioning booster seat, a child bicycle helmet, and a smoke alarm. Prices of child and family safety devices varied widely between countries but the variation for child safety seats and bicycle helmets did not relate strongly to country income. Safety devices were expensive, often prohibitively so, in lower income countries. Far more hours of factory work were required to earn a child safety device in lower income than middle income, and middle income than higher income, countries. A bicycle helmet, for example, cost 10 hours of factory work in lower income countries but less than an hour in higher income countries. Smoke alarms and booster seats were not available in many lower income countries. Bicycles and two-axle motor vehicles were numerous in lower and middle income countries, but corresponding child safety devices were often unaffordable and sometimes not readily available. The apparent market distortions and their causes merit investigation. Advocacy, social marketing, local device production, lowering of tariffs, and mandatory use legislation might stimulate market growth. Arguably, a moral obligation exists to offer subsidies that give all children a fair chance of surviving to adulthood.

  14. Design Specifications for the Hanstholm WEPTOS Wave Energy Converter

    Directory of Open Access Journals (Sweden)

    Tommy Larsen

    2012-04-01

    Full Text Available The WEPTOS wave energy converter (WEC is a novel device that combines an established and efficient wave energy absorbing mechanism with a smart structure, which can regulate the amount of incoming wave energy and reduce loads in extreme wave conditions. This adjustable A-shaped slack-moored and floating structure absorbs the energy of the waves through a multitude of rotors. The shape of the rotors is based on the renowned Salter’s Duck. On each leg, the rotors pivot around a common axle, through which the rotors transfer the absorbed power to a common power take off system. The study investigates the required capacity of the power take off (PTO system and the structural forces on a WEPTOS WEC prototype, intended for installation at Hanstholm (Denmark, based on large scale experimental tests using a highly realistic laboratory model of the complete device. The results hereof includes the rotational speed and transmitted torque (and hereby power to the PTO system using different PTO control strategies, the impact of fluctuations of the available mechanical power and the effect of limiting the PTO capacity on the annual energy production. Acquisition of structural forces includes mooring forces and structural bending moments in both production and extreme wave conditions, illustrating that the regulation of the angle in the A shape ensures that extreme forces on the structure can be kept in the same order of magnitude as in production conditions.

  15. Stability enhancement and fuel economy of the 4-wheel-drive hybrid electric vehicles by optimal tyre force distribution

    Science.gov (United States)

    Goodarzi, Avesta; Mohammadi, Masoud

    2014-04-01

    In this paper, vehicle stability control and fuel economy for a 4-wheel-drive hybrid vehicle are investigated. The integrated controller is designed within three layers. The first layer determines the total yaw moment and total lateral force made by using an optimal controller method to follow the desired dynamic behaviour of a vehicle. The second layer determines optimum tyre force distribution in order to optimise tyre usage and find out how the tyres should share longitudinal and lateral forces to achieve a target vehicle response under the assumption that all four wheels can be independently steered, driven, and braked. In the third layer, the active steering, wheel slip, and electrical motor torque controllers are designed. In the front axle, internal combustion engine (ICE) is coupled to an electric motor (EM). The control strategy has to determine the power distribution between ICE and EM to minimise fuel consumption and allowing the vehicle to be charge sustaining. Finally, simulations performed in MATLAB/SIMULINK environment show that the proposed structure could enhance the vehicle stability and fuel economy in different manoeuvres.

  16. Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis.

    Science.gov (United States)

    Ruprecht, Benjamin; Zaal, Esther A; Zecha, Jana; Wu, Wei; Berkers, Celia R; Kuster, Bernhard; Lemeer, Simone

    2017-04-15

    HER2/ERBB2-overexpressing breast cancers targeted effectively by the small-molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study, we employed explorative mass spectrometry to profile proteome, kinome, and phosphoproteome changes in an established model of lapatinib resistance to systematically investigate initial inhibitor response and subsequent reprogramming in resistance. The resulting dataset, which collectively contains quantitative data for >7,800 proteins, >300 protein kinases, and >15,000 phosphopeptides, enabled deep insight into signaling recovery and molecular reprogramming upon resistance. Our data-driven approach confirmed previously described mechanisms of resistance (e.g., AXL overexpression and PIK3 reactivation), revealed novel pharmacologically actionable targets, and confirmed the expectation of significant heterogeneity in molecular resistance drivers inducing distinct phenotypic changes. Furthermore, our approach identified an extensive and exclusively phosphorylation-mediated reprogramming of glycolytic activity, supported additionally by widespread changes of corresponding metabolites and an increased sensitivity towards glycolysis inhibition. Collectively, our multi-omic analysis offers deeper perspectives on cancer drug resistance and suggests new biomarkers and treatment options for lapatinib-resistant cancers. Cancer Res; 77(8); 1842-53. ©2017 AACR . ©2017 American Association for Cancer Research.

  17. Based on the traffic system tools magneto electric equipment design and application

    Directory of Open Access Journals (Sweden)

    Sun Jian

    2017-01-01

    Full Text Available In transportation, the road is rough, the engine operation, the instability of the transmission system, and large vibration of the vibration system is to collect the vibration energy, and transformed into stable electricity, provide extra energy for transportation. Experiment device of the system is composed of three parts: simulate vibration test rig, vibration generating device, rectifier voltage regulator circuit. Vibration table is to simulate vehicle vibration in the road, cars, for example, through the check information that cars drive in ordinary road driving axle of some vibration data, thus to calculate all parameters of the vibration table. Vibration generating device is placed on the simulation vibration table, it can convert vibration energy into cars can use electricity. Rectifier voltage regulator circuit is generated by power generation device with a range of random variation of amplitude of electric energy through the rectifier voltage into a stable power output, for car use. The final design and making the vibration system, obtained by the method of experiment proved that the vibration of system feasible.

  18. Automated system for crack detection using infrared thermograph

    International Nuclear Information System (INIS)

    Starman, Stanislav

    2009-01-01

    The objective of this study was the development of the automated system for crack detection on square steel bars used in the automotive industry for axle and shaft construction. The automated system for thermographic crack detection uses brief pulsed eddy currents to heat steel components under inspection. Cracks, if present, will disturb the current flow and so generate changes in the temperature profile in the crack area. These changes of temperature are visualized using an infrared camera. The image acquired by the infrared camera is evaluated through an image processing system. The advantages afforded by the system are its inspection time, its excellent flaw detection sensitivity and its ability to detect hidden, subsurface cracks. The automated system consists of four IR cameras (each side of steel bar is evaluated at a time), coil, high frequency generator and control place with computers. The system is a part of the inspection line where the subsurface and surface cracks are searched. If the crack is present, the cracked place is automatically marked. The components without cracks are then deposited apart from defective blocks. The system is fully automated and its ability is to evaluate four meter blocks within 20 seconds. This is the real reason for using this system in real industrial applications. (author)

  19. Friction in carborane-based molecular rotors driven by gas flow or electric field: classical molecular dynamics.

    Science.gov (United States)

    Prokop, Alexandr; Vacek, Jaroslav; Michl, Josef

    2012-03-27

    Friction in molecular rotors is examined by classical molecular dynamics simulations for grid-mounted azimuthal dipolar molecular rotors, whose rotation is either allowed to decay freely or is driven at GHz frequencies by a flow of rare gas or by a rotating electric field. The rotating parts (rotators) are propeller-shaped. Their two to six blades consist of condensed aromatic rings and are attached to a deltahedral carborane hub, whose antipodal carbons carry [n]staffane axles mounted on a square molecular grid. The dynamic friction constant η has been derived in several independent ways with similar results. Analysis of free rotation decay yields η as a continuous exponentially decreasing function of rotor frequency. The calculated dependence of friction torque on frequency resembles the classical macroscopic Stribeck curve. Its relation to rotational potential energy barriers and the key role of the rate of intramolecular vibrational redistribution (IVR) of energy and angular momentum from rotator rotation to other modes are considered in two limiting regimes. (i) In the strongly overdamped regime, rotation is much slower than IVR, and effective friction can be expressed through potential barriers to rotation. (ii) In the strongly underdamped regime, rotation is much faster than IVR, whose rate then determines friction. © 2012 American Chemical Society

  20. New markers in pelvic inflammatory disease.

    Science.gov (United States)

    Yang, Shun-Fa; Wu, Tzu-Fan; Tsai, Hsiu-Ting; Lin, Long-Yau; Wang, Po-Hui

    2014-04-20

    Pelvic inflammatory disease (PID) is a common infection in women of reproductive age. However, diagnosis of PID can be difficult due to the wide variation in the symptoms and signs, ranging from subtle or mild symptoms to severe pain in the lower abdomen. Clinical diagnosis alone has only 87% sensitivity and 50% specificity. Therefore, identifying biological factors that are useful for early diagnosis and correlating their expression with the severity of PID could provide significant benefits to women suffering from PID. Pentraxin 3 (PTX3), E-cadherin, myeloperoxidase, stromal cell-derived factor 1 (SDF-1) and the matrix metalloproteinase-9 (MMP-9)/MMP-2 ratio are potential candidates for detecting PID reliably. As PID is often subtle, highly sensitive PID detection methods are needed to promote the prevention of severe sequelae. Growth arrest-specific 6 (Gas6), in combination with its soluble tyrosine kinase receptor, sAxl, could elevate the sensitivity to 92%, which was higher than all other markers tested. Moreover, PTX3, D-dimer and YKL-40 concentrations can predict the clinical course of PID. Although single nucleotide polymorphisms of biomarker genes are not associated with the development of PID, myeloperoxidase SNP -463 G/A and SDF-1 SNP 801 G/A may affect the aggravated expression of their biomarkers in PID. Copyright © 2014. Published by Elsevier B.V.