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Sample records for avastin gbm briefing

  1. GBM Accreting Pulsar Histories

    Data.gov (United States)

    National Aeronautics and Space Administration — For each source we plot the history of pulse frequency and pulsed flux measured using the Fermi Gamma-Ray Burst Monitor (GBM) NaI detectors. For these measurements...

  2. GBM Spectral Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — For GBM, input is daily or trigger CSPEC or CTIME file from Fermi archive and corresponding response file from our archive. For LAT, input is daily spectrum file and...

  3. GBM Response Matrix FITS Files

    Data.gov (United States)

    National Aeronautics and Space Administration — Time-dependent detector response matrices for each GBM detector covering the duration of every GBM flare. Needed in the spectral analysis software to relate observed...

  4. FERMIGTRIG - Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by one or more of the 14 GBM detectors (12 NaI and 2 BGO). Note that there are two Browse catalogs resulting from GBM...

  5. Prepare of Avastin-chitosetn nanoparticles%Avastin-壳聚糖纳米粒的制备

    Institute of Scientific and Technical Information of China (English)

    周楠; 黄潇; 李玉珍; 程金伟; 蔡季平

    2012-01-01

    目的 以壳聚糖( chitosan,CS)为药物载体,制备Avastin-CS纳米粒(Avastin-CS-NP),并对其体外释药特性进行初步研究.方法 采用离子胶凝法合成Avastin-CS-NP,用马尔文激光粒径分析仪测试纳米粒径及其分布,透射电镜观察纳米粒形态,用Micro-BCA法对所制得的纳米粒包封率、载药量进行测定,观察Avastin-CS-NP体外释放曲线,对其体外稳定性进行初步考察.结果 本研究所制得的Avastin-CS-NP,外观形态呈圆形或类圆形,大小较均匀,粒度分布较窄,平均粒径为88.9 nm;纳米制剂的包封率、载药量分别为83.4%和10.4%;体外累积释药实验表明,前8h释药达25.70%,有突释效应,随后逐渐缓慢,96h内共释放80% ~ 90%,具有良好的体外稳定性.结论 该纳米制剂具有较好的物理性能与体外缓释特性.%Objective To choose chitosan as the drug carrier and to prepare the Avastin-chitosan nanoparticles (Avastin-CS-NP) with extraorgan release. Methods The Avastin-CS-NP was prepared according to the ionotropic gelation. The size and distribution of nanoparticles (NP) were measured using the Malvern laser master-sizer and the morphology of NP was observed by transmission electron microscope (TEM). The encapsulation rate and loading concentration of nanoparticles were measured by means of Micro-BCA. The release curve in vitro of Avastin-CS-NP as observed and its stability was observed. Results The morphology of Abastin-CS-NP was round or near round, and the size was regular. Particle size spread narrow and the average diameter was 88.9 nm. The encapsulation efficiency and loading concentration of Avastin-CS-NP were 83.4% and 10. 4% , respectively. In vitro release studies showed that the drug release from chitosan based nanoparticle systems was typified by a 25.70% initial rapid release (burst effect) within the first 8 hours followed by a steady release as 80% to 90% extended for 96 hours. Conclusion The nanoparticles possess

  6. FERMIGBRST - Fermi GBM Burst Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by a subset of the 14 GBM detectors (12 NaI and 2 BGO) which have been classified as gamma-ray bursts (GRBs). Note that...

  7. Effect of Avastin on the migration and invasion of pterygium fibroblasts

    Institute of Scientific and Technical Information of China (English)

    Wei Liu; Xiangyin Sha; Ye Wen; Wenting Zhao; Wei Luo; Zanmei Hua

    2014-01-01

    Purpose:.To evaluate the effect of Avastin on human ptery-gium fibroblast migration and invasiveness. Methods:.VEGF secretion was compared between human pterygium fibroblasts and conjunctival fibroblasts by measur-ing VEGF-A by ELISA. The influence of Avastin on HPF mi-gration and invasiveness was observed by wound scratch and Transwell migration assays..The expression of p-ERK1/2 and p-FAK was analyzed by western blotting. Results: (1)VEGF was secreted in higher amounts by human pterygium fibroblasts than by conjunctival fibroblasts. (2) Avastin treatment decreased HPF migration and invasion. (3) Avastin significantly decreased the expression of p-ERK1/2 and p-FAK in human pterygium fibroblasts. Conclusion:.Avastin can inhibit migration and invasion of HPFs by decreasing the expression of p-ERK1/2 and p-FAK.

  8. Gamma-Ray Astrophysics NSSTC Fermi GBM

    Data.gov (United States)

    National Aeronautics and Space Administration — The Fermi Gamma-Ray Burst Monitor (GBM) is not a pointed or imaging instrument. To determine fluxes for known sources, we measure the change in the count rate...

  9. Magnetar Observations with Fermi/GBM

    Science.gov (United States)

    Kouveliotou, Chryssa

    2009-01-01

    NASA's Fermi Observatory was launched June 11, 2009; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. In the first year of operations we recorded emission from four magnetar sources; of these, only one was an old magnetar: SGR 1806+20. The other three detections were: SGR J0501+4516, newly discovered with Swift and extensively monitored with both Swift and GBM, SGR J1550-5418, a source originally classified as an Anomalous X-ray Pulsar (AXP) and a very recently discovered new source, SGR 0418+5729. I report below on the current status of the analyses efforts of the GBM data.

  10. Anti-GBM Disease in Pregnancy

    Directory of Open Access Journals (Sweden)

    Mohammed Muqeet Adnan MD

    2015-12-01

    Full Text Available Antiglomerular basement membrane (GBM disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient’s request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.

  11. Three years of Transients with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2012-01-01

    The Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument, sensitive between 8 keV and 40 MeV, with a primary objective of supporting the Large Area Telescope (LAT) in observations of Gamma-Ray Bursts (GRBs). Both instruments are part of the Fermi Gamma-ray Space Telescope. Together, the GBM and LAT instruments have provided ground-breaking measurements of GRBs that have, after 10 years of focus on GRB afterglows, inspired renewed interest in the prompt emission phase of GRBs and the physical mechanisms that fuel them. In addition to GRB science, GBM has made significant contributions to the astrophysics of galactic transient sources including long-term variations in the Crab nebula, spin state transitions in accretion powered pulsars, state transitions in black hole X-ray binaries, and unprecedented time-resolved spectral studies of soft gamma-ray repeater bursts. Closer to home, GBM also contributes to solar flare and terrestrial gamma flash science.

  12. TCGA Workshop: Genomics and Biology of Glioblastoma Multiforme (GBM) - TCGA

    Science.gov (United States)

    The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) held a workshop entitled, “Genomics and Biology of Glioblastoma Multiforme (GBM),” to review the initial GBM data from the TCGA pilot project.

  13. Public voices in pharmaceutical deliberations: negotiating "clinical benefit" in the FDA's Avastin Hearing.

    Science.gov (United States)

    Teston, Christa B; Graham, S Scott; Baldwinson, Raquel; Li, Andria; Swift, Jessamyn

    2014-06-01

    This article offers a hybrid rhetorical-qualitative discourse analysis of the FDA's 2011 Avastin Hearing, which considered the revocation of the breast cancer indication for the popular cancer drug Avastin. We explore the multiplicity of stakeholders, the questions that motivated deliberations, and the kinds of evidence presented during the hearing. Pairing our findings with contemporary scholarship in rhetorical stasis theory, Mol's (2002) construct of multiple ontologies, and Callon, Lascoumes, and Barthe's (2011) "hybrid forums," we demonstrate that the FDA's deliberative procedures elides various sources of evidence and the potential multiplicity of definitions for "clinical benefit." Our findings suggest that while the FDA invited multiple stakeholders to offer testimony, there are ways that the FDA might have more meaningfully incorporated public voices in the deliberative process. We conclude with suggestions for how a true hybrid forum might be deployed.

  14. Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat.

    Directory of Open Access Journals (Sweden)

    Yan-Yan Zhao

    Full Text Available The similarity between a proposed biosimilar product and the reference product can be affected by many factors. This study is designed to examine whether any subtle difference in the distribution of the charge variants of an Avastin biosimilar can affect its in vitro potency and in vivo PK. Here, the acidic, basic and main peak fractions of a biosimilar product were isolated using high-performance cation-exchange chromatography and were subjected to various studies to compare their in vitro properties and in vivo PK profile. A serial of analytical methods, including size exclusion chromatography (SEC, imaged capillary isoelectric focusing (icIEF capillary zone electrophoresis (CZE and cation-exchange chromatography (CEX-HPLC were also used to characterize the isolated charge variants. The kinetics constant was measured using a Biacore X100 system. The study indicates the biosimilar product has a high similarity with avastin in physicochemical properties. The potency in vitro and PK profile in rat of charge variants and biosimilar product are consistent with avastin.

  15. All-Sky Monitoring of Variable Sources with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Cherry, Michael L.; Case, Gary L.; Camero-Arranz, Ascension; Chaplin, Vandiver; Connaughton, Valerie; Finger, Mark H.; Jenke, Pater; Rodi, James C.; Baumgartner, Wayne H.; Beklen, Elif; Bhat, P. Narayana; Briggs, Michael S.; Gehrels, Neil; Greiner, Jochen; Jahoda, Keith; Kippen, R. Marc; Kouveliotou, Chryssa; Krimm, Hans A.; Kuulkers, Erik; Lund, Niels; Meegan, Charles A.; Natalucci, Lorenzo; Paciesas, William S.; Preece, Robert

    2011-01-01

    This slide presentation reviews the monitoring of variable sources with the Fermi Gamma Ray Burst Monitor (GBM). It reviews the use of the Earth Occultation technique, the observations of the Crab Nebula with the GBM, and the comparison with other satellite's observations. The instruments on board the four satellites indicate a decline in the Crab from 2008-2010.

  16. Interest of a treatment combined by radioimmunotherapy and Avastin 1 in a murine model of thyroid medullary carcinoma; Interet d'un traitement combine par radioimmunotherapie et Avastin1 dans un modele murin de carcinome medullaire de la thyroide

    Energy Technology Data Exchange (ETDEWEB)

    Salaun, P.Y.; Bodet-Milin, C.; Paris, F.; Frampas, E.; Sai Maurel, C.; Faivre Chauvet, A.; Barbet, J.; Kraeber Bodere, F. [Unite Inserm U892, Brest, (France)

    2009-05-15

    The objective of this study was to evaluate the efficiency and the toxicity of the association radioimmunotherapy and bevacizumab on a murine model grafted by the human line T.T. of thyroid medullar cancer. After results it appears that in pretreatment, bevacizumab (Avastin) improves the efficiency of radioimmunotherapy without increasing the toxicity face the radioimmunotherapy alone. (N.C.)

  17. La gestion de l’Avastin par le bioéthicien : transfert d’une responsabilité politique?

    Directory of Open Access Journals (Sweden)

    Laliberté, Maude

    2012-05-01

    Full Text Available Avastin is a paradigmatic example of a common situation in the health system: the introduction of promising but very expensive new drugs. This situation disrupts the delicate balance of the health system and causes problems for various stakeholders such as patients, health professionals, bioethicists and managers.

  18. Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin® for AMD followed by controlateral sympathetic ophthalmia

    Directory of Open Access Journals (Sweden)

    Dimitrios Brouzas

    2009-08-01

    Full Text Available Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®, in a patient with exudative age-related macular degeneration (AMD.Patients and method: Case report.Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.Conclusion: Serious ocular complications after intravitreal of Avastin® can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.Keywords: Avastin® complication, intravitreal injection, choroidal detachment, Phthisis bulbi, sympathetic ophthalmia

  19. Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features.

    Science.gov (United States)

    Rios Velazquez, Emmanuel; Meier, Raphael; Dunn, William D; Alexander, Brian; Wiest, Roland; Bauer, Stefan; Gutman, David A; Reyes, Mauricio; Aerts, Hugo J W L

    2015-11-18

    Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. MRI sets of 109 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA). Spearman's correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Auto-segmented sub-volumes showed moderate to high agreement with manually delineated volumes (range (r): 0.4 - 0.86). Also, the auto and manual volumes showed similar correlation with VASARI features (auto r = 0.35, 0.43 and 0.36; manual r = 0.17, 0.67, 0.41, for contrast-enhancing, necrosis and edema, respectively). The auto-segmented contrast-enhancing volume and post-contrast abnormal volume showed the highest AUC (0.66, CI: 0.55-0.77 and 0.65, CI: 0.54-0.76), comparable to manually defined volumes (0.64, CI: 0.53-0.75 and 0.63, CI: 0.52-0.74, respectively). BraTumIA and manual tumor sub-compartments showed comparable performance in terms of prognosis and correlation with VASARI features. This method can enable more reproducible definition and quantification of imaging based biomarkers and has potential in high-throughput medical imaging research.

  20. Comparative analyses of gene copy number and mRNA expression in GBM tumors and GBM xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, J. Graeme; Yeh, Ru-Fang; Ray, Amrita; Wang, Nicholas J.; Smirnov, Ivan; Yu, Mamie; Hariono, Sujatmi; Silber, Joachim; Feiler, Heidi S.; Gray, Joe W.; Spellman, Paul T.; Vandenberg, Scott R.; Berger, Mitchel S.; James, C. David

    2009-04-03

    Development of model systems that recapitulate the molecular heterogeneity observed among glioblastoma multiforme (GBM) tumors will expedite the testing of targeted molecular therapeutic strategies for GBM treatment. In this study, we profiled DNA copy number and mRNA expression in 21 independent GBM tumor lines maintained as subcutaneous xenografts (GBMX), and compared GBMX molecular signatures to those observed in GBM clinical specimens derived from the Cancer Genome Atlas (TCGA). The predominant copy number signature in both tumor groups was defined by chromosome-7 gain/chromosome-10 loss, a poor-prognosis genetic signature. We also observed, at frequencies similar to that detected in TCGA GBM tumors, genomic amplification and overexpression of known GBM oncogenes, such as EGFR, MDM2, CDK6, and MYCN, and novel genes, including NUP107, SLC35E3, MMP1, MMP13, and DDX1. The transcriptional signature of GBMX tumors, which was stable over multiple subcutaneous passages, was defined by overexpression of genes involved in M phase, DNA replication, and chromosome organization (MRC) and was highly similar to the poor-prognosis mitosis and cell-cycle module (MCM) in GBM. Assessment of gene expression in TCGA-derived GBMs revealed overexpression of MRC cancer genes AURKB, BIRC5, CCNB1, CCNB2, CDC2, CDK2, and FOXM1, which form a transcriptional network important for G2/M progression and/or checkpoint activation. Our study supports propagation of GBM tumors as subcutaneous xenografts as a useful approach for sustaining key molecular characteristics of patient tumors, and highlights therapeutic opportunities conferred by this GBMX tumor panel for testing targeted therapeutic strategies for GBM treatment.

  1. Magnetar Observations in the Swift-Fermi/GBM Era

    Science.gov (United States)

    Kouveliotou, Chryssa

    2010-01-01

    NASA's Fermi Observatory was launched June 11, 2008; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. Since then, and against all odds, GBM recorded over 600 bursts from 4 SGRs. Of these four sources, only one was an old magnetar: SGR J1806+20. SGR J0501+4516, was discovered with Swift and extensively monitored with GBM. A source originally classified as AXP 1E1547.0-5408 exhibited SGR-like bursting behavior and we reclassified it as SGR J1550-5418. Finally, GBM discovered SGR J0418+5729 on 2009 June. Finally, on March 2010, a third new magnetar was discovered with Swift, SGR J1833-0832. I report below on the current status of the field and on several results combining multi-satellite and ground-based data

  2. Anti-GBM disease and renal vein thrombosis.

    Science.gov (United States)

    Bailey, Phillippa; Sarfraz, Farook; Ravanan, Rommel

    2011-11-15

    A 23-year-old female who presented with advanced renal failure was subsequently diagnosed with renal vein thrombosis and antiglomerular basement membrane (GBM) antibody disease. A previous case of renal vein thrombosis has been reported in association with anti-GBM disease, but to our knowledge, this is the first reported case in which the presentation of anti-GBM disease and renal vein thrombosis was concurrent. Further study is essential to understand if the association of anti-GBM disease and renal vein thrombosis as seen in our case was pure coincidence or is in fact occurs more frequently. It may be that the dual diagnosis is not made as establishing one sufficient diagnosis for renal failure may halt further investigations for additional diagnoses.

  3. GBM heterogeneity characterization by radiomic analysis of phenotype anatomical planes

    Science.gov (United States)

    Chaddad, Ahmad; Desrosiers, Christian; Toews, Matthew

    2016-03-01

    Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system, characterized among other traits by rapid metastatis. Three tissue phenotypes closely associated with GBMs, namely, necrosis (N), contrast enhancement (CE), and edema/invasion (E), exhibit characteristic patterns of texture heterogeneity in magnetic resonance images (MRI). In this study, we propose a novel model to characterize GBM tissue phenotypes using gray level co-occurrence matrices (GLCM) in three anatomical planes. The GLCM encodes local image patches in terms of informative, orientation-invariant texture descriptors, which are used here to sub-classify GBM tissue phenotypes. Experiments demonstrate the model on MRI data of 41 GBM patients, obtained from the cancer genome atlas (TCGA). Intensity-based automatic image registration is applied to align corresponding pairs of fixed T1˗weighted (T1˗WI) post-contrast and fluid attenuated inversion recovery (FLAIR) images. GBM tissue regions are then segmented using the 3D Slicer tool. Texture features are computed from 12 quantifier functions operating on GLCM descriptors, that are generated from MRI intensities within segmented GBM tissue regions. Various classifier models are used to evaluate the effectiveness of texture features for discriminating between GBM phenotypes. Results based on T1-WI scans showed a phenotype classification accuracy of over 88.14%, a sensitivity of 85.37% and a specificity of 96.1%, using the linear discriminant analysis (LDA) classifier. This model has the potential to provide important characteristics of tumors, which can be used for the sub-classification of GBM phenotypes.

  4. Visualizing molecular profiles of glioblastoma with GBM-BioDP.

    Directory of Open Access Journals (Sweden)

    Orieta Celiku

    Full Text Available Validation of clinical biomarkers and response to therapy is a challenging topic in cancer research. An important source of information for virtual validation is the datasets generated from multi-center cancer research projects such as The Cancer Genome Atlas project (TCGA. These data enable investigation of genetic and epigenetic changes responsible for cancer onset and progression, response to cancer therapies, and discovery of the molecular profiles of various cancers. However, these analyses often require bulk download of data and substantial bioinformatics expertise, which can be intimidating for investigators. Here, we report on the development of a new resource available to scientists: a data base called Glioblastoma Bio Discovery Portal (GBM-BioDP. GBM-BioDP is a free web-accessible resource that hosts a subset of the glioblastoma TCGA data and enables an intuitive query and interactive display of the resultant data. This resource provides visualization tools for the exploration of gene, miRNA, and protein expression, differential expression within the subtypes of GBM, and potential associations with clinical outcome, which are useful for virtual biological validation. The tool may also enable generation of hypotheses on how therapies impact GBM molecular profiles, which can help in personalization of treatment for optimal outcome. The resource can be accessed freely at http://gbm-biodp.nci.nih.gov (a tutorial is included.

  5. THE FIVE YEAR FERMI/GBM MAGNETAR BURST CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Collazzi, A. C. [SciTec, Inc., 100 Wall Street, Princeton, NJ 08540 (United States); Kouveliotou, C.; Horst, A. J. van der; Younes, G. A. [Department of Physics, The George Washington University, 725 21st Street NW, Washington, DC 20052 (United States); Kaneko, Y.; Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); Lin, L. [François Arago Centre, APC, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris (France); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Raanana 43537 (Israel); Finger, M. H. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Chaplin, V. L. [School of Medicine, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 (United States); Huppenkothen, D. [Center for Data Science, New York University, 726 Broadway, 7th Floor, New York, NY 10003 (United States); Watts, A. L. [Anton Pannekoek Institute, University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Kienlin, A. von [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H., E-mail: acollazzi@scitec.com [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2015-05-15

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550–5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  6. Fermi GBM Observations of LIGO Gravitational Wave event GW150914

    CERN Document Server

    Connaughton, V; Goldstein, A; Briggs, M S; Zhang, B -B; Hui, C M; Jenke, P; Racusin, J; Wilson-Hodge, C A; Bhat, P N; Cleveland, W; Fitzpatrick, G; Giles, M M; Gibby, M H; Greiner, J; von Kienlin, A; Kippen, R M; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O; Sparke, L; Stanbro, M; Toelge, K; Veres, P; Yu, H -F; authors, other

    2016-01-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO)event GW150914 reveal the presence of a weak transient source above 50 keV, 0.4 s after the GW event was detected, with a false alarm probability of 0.0022. This weak transient lasting 1 s does not appear connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event suggest it is a weak short Gamma-Ray Burst arriving at a large angle to the direction in which Fermi was pointing, where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, this electromagnetic signal from a stellar mass black hole binary merger is unexpected....

  7. The Five Year Fermi/GBM Magnetar Burst Catalog

    NARCIS (Netherlands)

    A.C. Collazzi; C. Kouveliotou; A.J. van der Horst; G.A. Younes; Y. Kaneko; E. Göğüş; L. Lin; J. Granot; M.H. Finger; V.L. Chaplin; D. Huppenkothen; A.L. Watts; A. von Kienlin; M.G. Baring; D. Gruber; P.N. Bhat; M.H. Gibby; N. Gehrels; J. Mcenery; M. van der Klis; R.A.M.J. Wijers

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present

  8. Recruitment of bone marrow derived cells during anti-angiogenic therapy in GBM : Bone marrow derived cell in GBM

    NARCIS (Netherlands)

    Boer, Jennifer C.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Glioblastoma (GBM) is a highly vascular tumor characterized by rapid and invasive tumor growth, followed by oxygen depletion, hypoxia and neovascularization, which generate a network of disorganized, tortuous and permeable vessels. Recruitment of bone marrow derived cells (BMDC) is crucial for vascu

  9. Safety and Efficacy of First-Line Bevacizumab Plus Chemotherapy in Elderly Patients with Advanced or Recurrent Nonsquamous Non-small Cell Lung Cancer Safety of Avastin in Lung trial (MO19390)

    NARCIS (Netherlands)

    Laskin, Janessa; Crino, Lucio; Felip, Enriqueta; Franke, Fabio; Gorbunova, Vera; Groen, Harry; Jiang, Guo-liang; Reck, Martin; Schneider, Claus-Peter

    2012-01-01

    Introduction: Safety of Avastin in Lung (MO19390) was an international, open-label, single-arm study, which assessed the safety and efficacy of first-line bevacizumab (Avastin (R)) in combination with standard chemotherapy in patients (n = 2212) with advanced or recurrent non-small cell lung cancer

  10. Intravitreal bevacizumab (Avastin treatment of diffuse diabetic macular edema in an Indian population

    Directory of Open Access Journals (Sweden)

    Kumar Atul

    2007-01-01

    Full Text Available Background: To report the anatomic and visual acuity response after intravitreal bevacizumab (Avastin in patients with diffuse diabetic macular edema. Design: Prospective, interventional case series study. Materials and Methods: This study included 20 eyes of metabolically stable diabetes mellitus with diffuse diabetic macular edema with a mean age of 59 years who were treated with two intravitreal injections of bevacizumab 1.25 mg in 0.05 ml six weeks apart. Main outcome measures were 1 early treatment diabetic retinopathy study visual acuity, 2 central macular thickness by optical coherence tomography imaging. Each was evaluated at baseline and follow-up visits. Results: All the eyes had received some form of laser photocoagulation before (not less than six months ago, but all of these patients had persistent diffuse macular edema with no improvement in visual acuity. All the patients received two injections of bevacizumab at an interval of six weeks per eye. No adverse events were observed, including endophthalmitis, inflammation and increased intraocular pressure or thromboembolic events in any patient. The mean baseline acuity was 20/494 (log Mar=1.338±0.455 and the mean acuity at three months following the second intravitreal injection was 20/295 (log Mar=1.094±0.254, a difference that was highly significant ( P =0.008. The mean central macular thickness at baseline was 492 µm which decreased to 369 µm ( P =0.001 at the end of six months. Conclusions: Initial treatment results of patients with diffuse diabetic macular edema not responding to previous photocoagulation did not reveal any short-term safety concerns. Intravitreal bevacizumab resulted in a significant decrease in macular thickness and improvement in visual acuity at three months but the effect was somewhat blunted, though still statistically significant at the end of six months.

  11. High-energy transients with Fermi/GBM

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, David

    2012-10-09

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These {gamma}-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of {gamma}-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in {gamma}-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (E{sub peak}) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility

  12. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    Science.gov (United States)

    Hurley, K.; Briggs, M.; Connaughton, V.; Meegan, C.; von Kienlin, A.; Rau, A.; Zhang, X.; Golenetskii, S.; Aptekar, R.; Mazets, E.; Pal'shin, V.; Fredericks, D.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Starr, R.; Goldsten, J.

    2012-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  13. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    CERN Document Server

    Hurley, K; Connaughton, V; Meegan, C; von Kienlin, A; Rau, A; Zhang, X; Golenetskii, S; Aptekar, R; Mazets, E; Pal'shin, V; Frederiks, D; Barthelmy, S; Cline, T; Cummings, J; Gehrels, N; Krimm, H A; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Starr, R; Smith, D M; Hajdas, W; Yamaoka, K; Ohno, M; Fukazawa, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Palmer, D M; Goldsten, J; Del Monte, E; Feroci, M; Marisaldi, M

    2011-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  14. AI-05IMPACT OF GBM MICROENVIRONMENT ON EXPRESSION PROFILE OF BONE MARROW DERIVED PROGENITOR CELLS

    OpenAIRE

    Burrell, Kelly; Singh, Sanjay; Agnihotri, Sameer; Hill, Richard; Aldape, Kenneth; Zadeh, Gelareh

    2014-01-01

    We have recently shown that bone marrow derived cells (BMDC) provide a distinct tumor region dependent contribution to glioblastoma multiforme (GBM) neovascularization. The influence of GBM microenvironment on differentiation and modulation of expression factors by BMDC however remains unknown. In this study we establish the differential expression profile of BMDC as a consequence of recruitment and interaction with the GBM microenvironment and in response to radiation (RTx) and anti-angiogen...

  15. Clinical and histological findings after intravitreal injection of bevacizumab (Avastin) in a porcine model of choroidal neovascularization

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik;

    2010-01-01

    was identified immunohistochemically in the inner limiting membrane (ILM) and to a lesser degree in the remaining retina. Strong staining was also detected in both retinal blood vessels and entire CNV membranes with no cellular predisposition. Vascular endothelial growth factor expression was found in the CNV...... membranes, in the ILM, in the ganglion cell layer, in Müller cells throughout the neuroretina and in retinal blood vessels. CONCLUSIONS: Bevacizumab significantly reduced the proliferation of vascular endothelial cells in CNV membranes and showed a strong trend towards a reduction of leakage from......PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes...

  16. Clinical and histological findings after intravitreal injection of bevacizumsb (Avastin®) in a porcine model of choroidal neovascularisation

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik;

    2010-01-01

    was identified immunohistochemically in the inner limiting membrane (ILM) and to a lesser degree in the remaining retina. Strong staining was also detected in both retinal blood vessels and entire CNV membranes with no cellular predisposition. Vascular endothelial growth factor expression was found in the CNV...... membranes, in the ILM, in the ganglion cell layer, in Müller cells throughout the neuroretina and in retinal blood vessels. CONCLUSIONS: Bevacizumab significantly reduced the proliferation of vascular endothelial cells in CNV membranes and showed a strong trend towards a reduction of leakage from......PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes...

  17. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.

    Science.gov (United States)

    Ali, Saad; Joseph, Nancy M; Perry, Arie; Barajas, Ramon F; Cha, Soonmee

    2014-09-01

    Glioblastoma (GBM) with primitive neuroectodermal tumor (PNET)-like (GBM-PNET) components is a rare variant of GBM. Recent studies describe PNET-like clinical behavior in these patients-with significantly increased propensity for CSF dissemination and a benefit of "PNET-like" chemotherapy. The imaging appearance of GBM-PNET is not well-described and given areas of marked cellularity in the PNET components one might expect significantly reduced diffusion on MRI. The purpose of this study is to quantitatively evaluate the diffusion characteristics in GBM-PNET and compare them with conventional GBMs. Nine patients with surgical specimens yielding GBM-PNET were identified from the UCSF Pathology files. MR images of these patients were reviewed retrospectively. DWI (diffusion-weighted imaging) sequences were analyzed with multiple regions of interests placed within the tumor, and ADC (apparent diffusion coefficient) values were measured. Results were compared to previously published ADC values in pathology-proven conventional GBM cases from our institution. Reduced ADC was seen in GBM-PNET (mean 581 × 10(-6) mm(2)/s, range 338-817) compared to previously published mean of 1,030 × 10(-6) mm(2)/s in the enhancing components of conventional GBMs. We report substantially reduced ADC values in GBM-PNETs compared to conventional GBMs. If demonstrated in a larger sample, when areas of marked reduced diffusion are seen in a suspected GBM, MRI may appropriately direct tissue sampling and can advocate a thorough search for PNET-like components on histopathology. These patients may have a higher chance of developing CSF dissemination and may benefit from "PNET-like" platinum-based chemotherapy.

  18. Comparative study of inhibition effects of Avastin and Lucentis on human umbilical vein endothelial cell proliferation and migration%Avastin与Lucentis对HUVEC增殖和迁移的抑制作用研究

    Institute of Scientific and Technical Information of China (English)

    金鑫; 陈兵; 刘铁城; 张卯年

    2013-01-01

    目的:探讨Avastin与Lucentis对人脐静脉血管内皮细胞(human umbilical vein endothelial cells,HUVEC)增殖和迁移的影响,了解其抑制血管生成的途径.方法:采用MTT比色法研究相同浓度Avastin与Lucentis 对HUVEC增殖作用的差异;Transwell小室检测相同浓度Avastin与Lucentis对HUVEC迁移作用的差异.结果:MTT比色法显示,各浓度Avastin组、Lucentis组与对照组相比,吸光度值具有统计学差异(P0.05);Transwell分析方法显示,各浓度Avastin组、Lucentis组与对照组相比,HUVEC迁移率具有统计学差异(P0.05).结论:Avastin与Lucentis均可以抑制HUVEC增殖和迁移;随着药物浓度增加,对HUVEC增殖和迁移的抑制作用增强;相同浓度Avastin与Lucentis在体外实验中对HUVEC增殖和迁移的抑制作用无统计学差异(P>0.05).%AIM: To investigate the effects of Avastin and Lucentis on human umbilical vein endothelial cell ( HUVEC ) proliferation and migration and study the ways of them inhibiting neovessels.METHODS: MTT was used to assay the different effects on proliferation of HUVEC between the same concentration of Avastin and Lucentis; Transwell was used to measure the different effects on inhibition of HUVEC between the same concentration of Avastin and Lucentis.RESULTS: MTT showed that A value was significantly different in the respective concentration Avastin groups, Lucentis groups and control group (P<0. 05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups. Transwell analysis showed that the rate of HUVEC migration was significantly different in the respective concentration Avastin groups, Lucentis groups and control group (P< 0. 05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups.CONCLUSION: Avastin and Lucentis could inhibit HUVEC proliferation and migration and inhibition effects of Avastin and Lucentis on HUVEC proliferation and

  19. A Grave Outcome of Posterior Reversible Encephalopathy Syndrome in a Patient Receiving Avastin (Bevacizumab for Metastatic High-Grade Serous Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Hind H. Elmalik

    2015-07-01

    Full Text Available A 45-year-old female developed neurological symptoms and elevated diastolic blood pressure while on bevacizumab (Avastin and gemcitabine for recurrent carboplatin-resistant high-grade serous ovarian cancer. A brain MRI diagnosed our patient with posterior reversible encephalopathy syndrome. We are discussing her presenting symptoms in this paper as well as the management and the outcome. We emphasize the importance of keeping this rare but very serious complication in all patients receiving bevacizumab.

  20. A Grave Outcome of Posterior Reversible Encephalopathy Syndrome in a Patient Receiving Avastin (Bevacizumab) for Metastatic High-Grade Serous Ovarian Cancer

    Science.gov (United States)

    Elmalik, Hind H.; ElAzzazy, Shereen; Salem, Khaled S.; Bujassoum, Salha

    2015-01-01

    A 45-year-old female developed neurological symptoms and elevated diastolic blood pressure while on bevacizumab (Avastin) and gemcitabine for recurrent carboplatin-resistant high-grade serous ovarian cancer. A brain MRI diagnosed our patient with posterior reversible encephalopathy syndrome. We are discussing her presenting symptoms in this paper as well as the management and the outcome. We emphasize the importance of keeping this rare but very serious complication in all patients receiving bevacizumab. PMID:26351436

  1. Fermi/GBM Observations of SGR J0501+4516

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; van der Horst, Alexander J.

    2011-08-01

    The magnetar candidate SGR J0501+4516 was discovered when it became active for about 13 days from August 22 to September 3, 2008. During this period, the Gamma-ray Burst Monitor (GBM) onboard Fermi detected over 30 bursts. We present here our results on the temporal and spectral analysis of the 29 bursts for which high spectral and time resolution data is available. We find that the T90 durations of the bursts follow a log-normal distribution with a mean value of ~123 ms. We fit the time-integrated spectrum of each burst with several models: a black body function, optically thin thermal brehmsstrahlung, a power law with an exponential cut-off, two black body functions, and the combination of a black body and a power law. We discuss our results in the context of the spectral properties of other magnetar bursts and we also present some correlations between the spectral parameters of the best fit models for all bursts. Finally, we present the results of our time-resolved spectral analysis of the five brightest bursts and discuss how they compare with our time-integrated results.

  2. Computer Implementation of a New Therapeutic Model for GBM Tumor

    Directory of Open Access Journals (Sweden)

    Ali Jamali Nazari

    2014-01-01

    Full Text Available Modeling the tumor behavior in the host organ as function of time and radiation dose has been a major study in the previous decades. Here the effort in estimation of cancerous and normal cell proliferation and growth in glioblastoma multiform (GBM tumor is presented. This paper introduces a new mathematical model in the form of differential equation of tumor growth. The model contains dose delivery amount in the treatment scheme as an input term. It also can be utilized to optimize the treatment process in order to increase the patient survival period. Gene expression programming (GEP as a new concept is used for estimating this model. The LQ model has also been applied to GEP as an initial value, causing acceleration and improvement of the algorithm estimation. The model shows the number of the tumor and normal brain cells during the treatment process using the status of normal and cancerous cells in the initiation of treatment, the timing and amount of dose delivery to the patient, and a coefficient that describes the brain condition. A critical level is defined for normal cell when the patient’s death occurs. In the end the model has been verified by clinical data obtained from previous accepted formulae and some of our experimental resources. The proposed model helps to predict tumor growth during treatment process in which further treatment processes can be controlled.

  3. Tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin®: relato de caso Treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin®: case report

    Directory of Open Access Journals (Sweden)

    Marcelo Mendes Lavezzo

    2010-08-01

    Full Text Available OBJETIVO: Relatar tratamento de retinopatia por radiação em paciente submetido à radioterapia por linfoma em órbita direita com injeção intravítrea de bevacizumab (Avastin®. Paciente de 55 anos, diabético, com diagnóstico de linfoma MALT orbitário há três anos, tratado com radioterapia local (dose: 35Gy há dois anos, com queixa de redução da acuidade visual do olho direito há quatro meses. Ao exame oftalmológico, apresentava alterações sugestivas de retinopatia por radiação, bem como espessura macular à tomografia de coerência óptica de 480 µm. Paciente foi submetido à injeção intravítrea (0,05 ml de bevacizumab (Avastin® no olho direito, apresentando redução do edema macular, bem como melhora discreta da acuidade visual. Neste caso, o tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin® foi relativamente útil, com melhora discreta da acuidade visual, devido à regressão do edema macular.PURPOSE: To report a case of radiation retinopathy treatment with intravitreal injection of bevacizumab (Avastin® in a patient undergoing radiotherapy for lymphoma in the right orbit. Patient of 55 years-old male, diabetic, diagnosed with an orbital MALT lymphoma three years ago, treated with local radiotherapy (dose: 35Gy two years ago, complaining of reduced visual acuity of the right eye for about four months. During the ophthalmologic evaluation, he had an exam suggestive of radiation retinopathy. Macular thickness at the optical coherence tomography was 480 µm. Patient was referred to intravitreal injection (0.05 ml of bevacizumab (Avastin® in the right eye, showing reduction of macular edema and mild improvement of visual acuity. In this case, the treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin® was relatively useful, with mild improvement of visual acuity due to the regression of macular edema.

  4. Crescentic Glomerulonephritis with Anti-GBM and p-ANCA Antibodies

    Directory of Open Access Journals (Sweden)

    Tariq Javed

    2012-01-01

    Full Text Available We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulonephritis with anti-GBM and p-ANCA positive patients. We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence.

  5. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

    Directory of Open Access Journals (Sweden)

    Tzuu-Yuan Huang

    2012-01-01

    Full Text Available Demethoxycurcumin (DMC; a curcumin-related demethoxy compound has been recently shown to display antioxidant and antitumor activities. It has also produced a potent chemopreventive action against cancer. In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells. We have studied the mitochondrial membrane potential (MMP, DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity. By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells. Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.

  6. Dismantling of the EB experiment: Experimental research on the retrieved GBM and bentonite blocks

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jiang-Feng, E-mail: jeafliu@hotmail.com [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China); Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Skoczylas, Frédéric [Laboratoire de Méchanique de Lille (LML), and École Centrale de Lille, BP 48, F-59651 Villeneuve d’Ascq Cedex (France); Talandier, Jean [ANDRA, 1-7 rue Jean Monnet, 92298 Châtenay-Malabry Cedex (France); Pu, Hai [State Key Laboratory for Geomchanics & Deep Underground Engineering, and School of Mechanics and Civil Engineering, China University of Mining & Technology, Xuzhou, Jiangsu 221116 (China)

    2016-04-15

    Graphical abstract: - Highlights: • We present a demonstration of a new concept of HLW (high-level waste) repositories. • The hydro-mechanical characteristics of GBM and blocks were determined. • The water retention curves (WRCs) of GBM and blocks were presented. • The effective gas permeability of the GBM and blocks were measured. • The homogeneity of the GBM and blocks were investigated. - Abstract: The Engineered Barrier Emplacement Experiment in Opalinus Clay (EB experiment) was a full-scale test for the demonstration of a new concept of high-level waste (HLW) repositories in horizontal drifts in the Opalinus Clay formation. After 10.5 years of hydration, the EB experiment was dismantled in autumn 2012. Samples obtained from the granular bentonite material (GBM), and bentonite blocks were sent to a laboratory for further analysis. The bentonite samples analyzed at the Laboratory of Mechanic of Lille (LML) were obtained from the CMT1, CMT2, CMT3 and RW sections. Their physical states were determined, as were their effective gas permeability and swelling capacity at different relative humidity (RH) levels. The results indicate that the water contents of the GBM determined in the laboratory ranged between 25.63% and 44.88% and that the dry densities ranged between 1.13 and 1.44 g/cm{sup 3}. The blocks had water contents similar to (or slightly higher than) those of the GBM, and their dry densities had decreased from an initial value of 1.69 g/cm{sup 3} to values close to 1.30 g/cm{sup 3}, which were similar to the average values found in the GBM. The effective gas permeabilities of the GBM samples were within the range of 1.50 × 10{sup −22} m{sup 2} and 1.03 × 10{sup −17} m{sup 2}, whereas, the corresponding values of the samples obtained from the blocks were between 2.20 × 10{sup −21} m{sup 2} and 5.12 × 10{sup −21} m{sup 2}. The permeability values are primarily related to the dry densities and water contents of the samples. Contact with

  7. THE INTERPLANETARY NETWORK SUPPLEMENT TO THE FERMI GBM CATALOG OF COSMIC GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, K. [University of California, Berkeley, Space Sciences Laboratory, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Pal' shin, V. D.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Mazets, E. P.; Svinkin, D. S. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Briggs, M. S.; Connaughton, V. [University of Alabama in Huntsville, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, C. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Goldsten, J. [Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723 (United States); Boynton, W.; Fellows, C.; Harshman, K. [University of Arizona, Department of Planetary Sciences, Tucson, AZ 85721 (United States); Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B. [Space Research Institute, 84/32, Profsoyuznaya, Moscow 117997 (Russian Federation); Rau, A., E-mail: khurley@ssl.berkeley.edu [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse, Postfach 1312, D-85748 Garching (Germany); and others

    2013-08-15

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 427 were observed by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could be improved by arrival time analysis (or {sup t}riangulation{sup )}. For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.'4 and 32 Degree-Sign , depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1{sigma} GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 Degree-Sign systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If we then multiply the resulting error radii by a factor of three, the two samples agree in slightly over 98% of the cases, providing a good estimate of the GBM 3{sigma} error radius. The IPN 3{sigma} error boxes have areas between about 1 arcmin{sup 2} and 110 deg{sup 2}, and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two bursts in the IPN/GBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrial gamma flash, and in the other, its origin was given as ''uncertain''. We also discuss the sensitivity and calibration of the IPN.

  8. On the Fermi-GBM Event 0.4 s after GW150914

    Science.gov (United States)

    Greiner, J.; Burgess, J. M.; Savchenko, V.; Yu, H.-F.

    2016-08-01

    In view of the recent report by Connaughton et al., we analyze continuous time-tagged event (TTE) data of Fermi-gamma-ray burst monitor (GBM) around the time of the gravitational-wave event GW 150914. We find that after proper accounting for low-count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broadband light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  9. On the GBM event seen 0.4 sec after GW 150914

    CERN Document Server

    Greiner, J; Savchenko, V; Yu, H -F

    2016-01-01

    In view of the recent report by Connaughton [arXiv:1602.03920.v3] we analyse continuous TTE data of Fermi-GBM around the time of the gravitational wave event GW 150914. We find that after proper accounting for low count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broad-band light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  10. Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.

    Science.gov (United States)

    St-Coeur, Patrick-Denis; Poitras, Julie J; Cuperlovic-Culf, Miroslava; Touaibia, Mohamed; Morin, Pier

    2015-10-01

    Glioblastoma multiforme (GBM) is the most common form of malignant glioma. Current therapeutic approach to treat this malignancy involves a combination of surgery, radiotherapy and chemotherapy with temozolomide. Numerous mechanisms contributing to inherent and acquired resistance to this chemotherapeutic agent have been identified and can lead to treatment failure. This study undertook a metabolomics-based approach to characterize the metabolic profiles observed in temozolomide-sensitive and temozolomide-resistant GBM cell lines as well as in a small sub-set of primary GBM tumors. This approach was also utilized to explore the metabolic changes modulated upon cell treatment with temozolomide and lomeguatrib, an MGMT inhibitor with temozolomide-sensitizing potential. Metabolites previously explored for their potential role in chemoresistance including glucose, citrate and isocitrate demonstrated elevated levels in temozolomide-resistant GBM cells. In addition, a signature of metabolites comprising alanine, choline, creatine and phosphorylcholine was identified as up-regulated in sensitive GBM cell line across different treatments. These results present the metabolic profiles associated with temozolomide response in selected GBM models and propose interesting leads that could be leveraged for the development of therapeutic or diagnostic tools to impact temozolomide response in GBMs.

  11. Is the GW150914-GBM really associated with the GW150914?

    CERN Document Server

    Xiong, Shaolin

    2016-01-01

    Finding the electromagnetic (EM) counterpart is critically important for a gravitational wave event. Although many efforts have been made to search for the purported EM counterpart of GW150914, the first gravitational wave event detected by LIGO, only Fermi/GBM reported an excess above background (i.e. GW150914-GBM) at 0.4 s after the LIGO trigger time, that is possibly associated with this GW event (Connaughton et al. 2016). However, since there is no significant detection by the INTEGRAL/SPI-ACS around the time of GW150914-GBM, a great debate has been raised about whether GW150914-GBM is of astrophysical origin and associated with the GW150914 (Savchenko et al. 2016). In order to answer this question, we re-analyzed the GBM data with a straightforward but sophisticated method. We find that the excess of GW150914-GBM mostly comes from those detectors with bad viewing angles to the GW event, whereas the good viewing detectors see nothing significant beyond background fluctuation around the trigger time of GW1...

  12. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  13. Is monthly retreatment with intravitreal bevacizumab (Avastin® necessary in neovascular age-related macular degeneration?

    Directory of Open Access Journals (Sweden)

    Nicola G Ghazi

    2010-04-01

    Full Text Available Nicola G Ghazi, Tyler Q Kirk, Robert M Knape, James S Tiedeman, Brian P ConwayDepartment of Ophthalmology, University of Virginia Health System, Charlottesville, VA, USAPurpose: To report our short-term experience with bevacizumab in neovascular age-related macular degeneration (AMD and recommend a new treatment strategy.Methods: Retrospective chart review of 29 consecutive patients receiving 1.25 mg of intravitreal bevacizumab for AMD and completing 12 weeks of follow up. Outcome measures were best corrected visual acuity (BCVA and optical coherence tomography (OCT central macular thickness. Injections were repeated if no further improvement was observed.Results: Twenty-nine eyes of 29 patients were included. The average BCVA improved from 20/148 at baseline to 20/106 at twelve weeks (P = 0.041. Of the 29 eyes, 25 (86.2% had stable or improved BCVA. Average mean central macular thickness measured by OCT improved from 351 μm at baseline to 278 μm at 12 weeks (P = 0.003. Stabilization of vision and improved OCT central macular thickness were maintained for at least eight weeks following only a single injection in the majority of eyes. During the three months of follow up, only five eyes (17.2% required repeat injections, with only three (10.3% requiring retreatment at eight weeks and none at four weeks. No significant ocular or systemic side effects were observed. Conclusion: This short-term data suggests that bevacizumab appears to be a safe and effective treatment for neovascular AMD. Injections as frequent as every month do not appear to be necessary since initial treatment effect appears to be maintained for at least eight weeks in almost all of our patients.Keywords: retina, Avastin®, bevacizumab, neovascular age-related macular degeneration, AMD

  14. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy

    Directory of Open Access Journals (Sweden)

    Vinay Minocha

    2014-01-01

    Full Text Available Introduction. The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN; however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency. We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM antibody. Case Presentation. We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis. Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units. A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. Conclusion. This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy. More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.

  15. THE SECOND FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST FOUR YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Von Kienlin, Andreas; Greiner, Jochen; Gruber, David [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Meegan, Charles A.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam [University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Paciesas, William S.; Cleveland, William [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Bissaldi, Elisabetta [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Byrne, David; Fitzpatrick, Gerard; Foley, Suzanne [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Collazzi, Andrew C. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., Huntsville, AL 35806 (United States); Guiriec, Sylvain [NASA-Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  16. The 2nd Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    CERN Document Server

    von Kienlin, Andreas; Paciesas, William S; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinead; Pelassa, Veronique; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50 - 300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10 - 1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM sci...

  17. The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    CERN Document Server

    Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Briggs, Michael S; Burgess, J Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H; Collazzi, Andrew C; Connaughto, Valerie; Diekmann, Anne M; Fitzpatrick, Gerard; Gibby, Melissa H; Giles, Misty M; Goldstein, Adam M; Greiner, Jochen; Jenke, Peter A; Kippen, R Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D; Roberts, Oliver J; Sparke, Linda S; Stanbro, Matthew; Veres, Peter; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-01-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRB...

  18. Implication of the association between GBM transient 150914 and LIGO Gravitational Wave event GW150914

    CERN Document Server

    Li, Xiang; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-01-01

    On September 14, 2015 the two detectors of LIGO simultaneously detected a transient gravitational-wave signal GW150914 and the Fermi GBM observations found a weak short gamma-ray burst (SGRB)-like transient (i.e., the GBM transient 150914). The time and location coincidences favor the association between GW150904 and GBM transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event is indeed a distinct outlier in the $E_{\\rm p,rest}-E_{\\rm iso}$ and $E_{\\rm p,rest}-L_{\\gamma}$ diagrams ($E_{\\rm iso}$ is the isotropic-equivalent energy, $L_\\gamma$ is the luminosity and $E_{\\rm p,rest}$ is the rest frame peak energy of the prompt emission), possibly due to its specific binary-black-hole merger origin. However, the presence of a "new" group of SGRBs with "low" $L_\\gamma$ and $E_{\\rm iso}$ but high $E_{\\rm p,rest}$ is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, we estimate the accretion disk mass to be $\\sim 10...

  19. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  20. The Fermi GBM and LAT follow-up of GW150914

    Directory of Open Access Journals (Sweden)

    Bissaldi E.

    2017-01-01

    Here we present observations by the Fermi Gamma-Ray BurstMonitor (GBM [1] and by the Large Area Telescope (LAT [2] of the LIGO Gravitational Wave event GW150914, which has been associated to the merger of two stellar-mass BHs. We report the presence of a weak transient event in GBM data, close in time to the LIGO one. We discuss the characteristics of this GBM transient, which are consistent with a weak short GRB arriving at a large angle to the direction in which Fermi was pointing. Furthermore, we report LAT upper limits (ULs for GW150914, and we present the strategy for follow-up observations of GW events with the LAT.

  1. Earth Occultation Monitoring of the Hard X-ray/Low-Energy Gamma Ray Sky with GBM

    Science.gov (United States)

    Cherry, Michael L.; Camero-Arranz, A.; Case, G. L.; Chaplin, V.; Finger, M. H.; Jenke, P. A.; Rodi, J. C.; Wilson-Hodge, C. A.; GBM Earth Occultation Team

    2012-01-01

    By utilizing the Earth occultation technique (EOT), the Gamma-Ray Burst Monitor (GBM) instrument aboard Fermi has been used to make nearly continuous full-sky observations in the 8-1000 keV energy range. The GBM EOT analysis program currently monitors an input catalog containing 235 sources. We will present the GBM catalog of sources observed in the first 3 years of the EOT monitoring program, with special emphasis on the high energy (>100 keV) and time-variable sources, in particular the Crab, Cyg X-1, and A0535+26. We will also describe the initial results of an all-sky imaging analysis of the EOT data, with comparisons to the Swift, INTEGRAL, and Fermi LAT catalogs. This work is supported by the NASA Fermi Guest Investigator program, NASA/Louisiana Board of Regents, and Spanish Ministerio de Ciencia de Innovacion.

  2. The Third Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    Science.gov (United States)

    Narayana Bhat, P.; Meegan, Charles A.; von Kienlin, Andreas; Paciesas, William S.; Briggs, Michael S.; Burgess, J. Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H.; Collazzi, Andrew C.; Connaughton, Valerie; Diekmann, Anne M.; Fitzpatrick, Gerard; Gibby, Melissa H.; Giles, Misty M.; Goldstein, Adam M.; Greiner, Jochen; Jenke, Peter A.; Kippen, R. Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D.; Roberts, Oliver J.; Sparke, Linda S.; Stanbro, Matthew; Veres, Péter; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-04-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two γ-ray bursts (GRBs) every three days. Here, we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years through the middle of 2014 July. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM-detected GRBs. For each GRB, the location and main characteristics of the prompt emission, the duration, peak flux, and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10 to 1000 keV, exploiting the full energy range of GBM's low-energy [Nai[Tl)] detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fit by a two-component model with short-hard and long-soft bursts than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  3. Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

    CERN Document Server

    Rodi, J; Case, G L; Camero-Arranz, A; Chaplin, C; Finger, M H; Jenke, P; Wilson-Hodge, C A

    2013-01-01

    The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. Imaging with a Differential filter using the Earth Occultation Method (IDEOM) has been developed to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT. IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky images have been generated for ~4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. Analysis resulted in the detection of 43 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. IDEOM analysis has resulted in the addition of 16 sources to the GBM-EOT catalog. We also present the first joined averaged spectra fo...

  4. Performance of two strategies for urgent ANCA and anti-GBM analysis in vasculitis

    NARCIS (Netherlands)

    de Joode, Anoek A. E.; Roozendaal, Caroline; van der Leij, Marcel J.; Bungener, Laura B.; Sanders, Jan Stephan; Stegeman, Coen A.

    2014-01-01

    Background: In anti-neutrophil cytoplasmic antibodies (ANCA) associated small vessel vasculitis (AAV), rapid testing for ANCA and anti-glomerular basement membrane (GBM) antibodies may be beneficial for therapeutic purpose. Objective: We analysed the diagnostic performance of two rapid ANCA and anti

  5. Implications of the Tentative Association between GW150914 and a Fermi-GBM Transient

    Science.gov (United States)

    Li, Xiang; Zhang, Fu-Wen; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-08-01

    The merger-driven gamma-ray bursts (GRBs) and their associated gravitational-wave (GW) radiation, if both are successfully detected, have some far-reaching implications, including, for instance: (i) the statistical comparison of the physical properties of the short/long-short GRBs with and without GW detection can test the general origin model; (ii) revealing the physical processes taking place at the central engine; (iii) measuring the velocity of the gravitational wave directly/accurately. In this work, we discuss these implications in the case of a possible association of GW150914/Gamma-ray Burst Monitor (GBM) transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event may be a distinct outlier in some statistical diagrams, possibly due to its specific binary black hole merger origin. However, the presence of a “new” group of SGRBs with “unusual” physical parameters is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, the magnetic activity rather than the neutrino process is likely responsible for the energy extraction, and the accretion disk mass is estimated to be ˜10-5 M ⊙. The GW150914/GBM transient 150914 association, if confirmed, would provide the first opportunity to directly measure the GW velocity, and its departure from the speed of the light should be within a factor of ˜10-17.

  6. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS.

  7. Fermi GBM Observations of LIGO Gravitational-wave Event GW150914

    Science.gov (United States)

    Connaughton, V.; Burns, E.; Goldstein, A.; Blackburn, L.; Briggs, M. S.; Zhang, B.-B.; Camp, J.; Christensen, N.; Hui, C. M.; Jenke, P.; Littenberg, T.; McEnery, J. E.; Racusin, J.; Shawhan, P.; Singer, L.; Veitch, J.; Wilson-Hodge, C. A.; Bhat, P. N.; Bissaldi, E.; Cleveland, W.; Fitzpatrick, G.; Giles, M. M.; Gibby, M. H.; von Kienlin, A.; Kippen, R. M.; McBreen, S.; Mailyan, B.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Roberts, O. J.; Sparke, L.; Stanbro, M.; Toelge, K.; Veres, P.

    2016-07-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational-wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914 reveal the presence of a weak transient above 50 keV, 0.4 s after the GW event, with a false-alarm probability of 0.0022 (2.9σ). This weak transient lasting 1 s was not detected by any other instrument and does not appear to be connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event are consistent with a weak short gamma-ray burst (GRB) arriving at a large angle to the direction in which Fermi was pointing where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, then this electromagnetic signal from a stellar mass black hole binary merger is unexpected. We calculate a luminosity in hard X-ray emission between 1 keV and 10 MeV of {1.8}-1.0+1.5× {10}49 erg s-1. Future joint observations of GW events by LIGO/Virgo and Fermi GBM could reveal whether the weak transient reported here is a plausible counterpart to GW150914 or a chance coincidence, and will further probe the connection between compact binary mergers and short GRBs.

  8. microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.

    Science.gov (United States)

    Tezcan, Gulcin; Tunca, Berrin; Bekar, Ahmet; Preusser, Matthias; Berghoff, Anna Sophie; Egeli, Unal; Cecener, Gulsah; Ricken, Gerda; Budak, Ferah; Taskapılıoglu, Mevlut Ozgur; Kocaeli, Hasan; Tolunay, Sahsine

    2014-07-01

    Temozolomide (TMZ) is widely used to treat glioblastoma multiforme (GBM). Although the MGMT gene methylation status is postulated to correlate with TMZ response, some patients with a methylated MGMT gene still do not benefit from TMZ therapy. Cancer stem cells (CSCs) may be one of the causes of therapeutic resistance, but the molecular mechanism underlying this resistance is unclear. microRNA (miRNA) deregulation has been recognized as another chemoresistance modulating mechanism. Thus, we aimed to evaluate the miRNA expression patterns associated with chemoresistance that is dependent on the CSC status in GBM tumors to identify therapeutic biomarkers. CSCs were identified in 5 of 20 patients' tumor tissues using magnetic separation. CSC (+) tumors displayed a significant induction of CpG island methylation in the MGMT gene promoter (p = 0.009). Using real-time reverse transcription polymerase chain reaction (qRT-PCR), 9 miRNAs related to GBM (mir-181b, miR-153, miR-137, miR-145, miR-10a, miR-10b, let-7d, miR-9, and miR-455-3p), which are associated with cell cycle and invasion was analyzed in tumor samples. Low miR-181b and high miR-455-3p expression levels were detected (p = 0.053, p = 0.004; respectively) in CSC (+) tumors. Analysis revealed a significant correlation between miR-455-3p expression and Smad2 protein levels as analyzed by immunohistochemistry in CSC (+) tumors (p = 0.002). Thus, miR-455-3p may be involved in TMZ resistance in MGMT methylated CSC (+) GBM patients. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for GBM treatment and new directions for the development of anticancer drugs.

  9. Tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin®): relato de caso

    OpenAIRE

    2010-01-01

    OBJETIVO: Relatar tratamento de retinopatia por radiação em paciente submetido à radioterapia por linfoma em órbita direita com injeção intravítrea de bevacizumab (Avastin®). Paciente de 55 anos, diabético, com diagnóstico de linfoma MALT orbitário há três anos, tratado com radioterapia local (dose: 35Gy) há dois anos, com queixa de redução da acuidade visual do olho direito há quatro meses. Ao exame oftalmológico, apresentava alterações sugestivas de retinopatia por radiação, bem como espess...

  10. TU-AB-BRA-11: Evaluation of Fully Automatic Volumetric GBM Segmentation in the TCGA-GBM Dataset: Prognosis and Correlation with VASARI Features

    Energy Technology Data Exchange (ETDEWEB)

    Rios Velazquez, E [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Meier, R [Institute for Surgical Technology and Biomechanics, Bern, NA (Switzerland); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Alexander, B [Dana- Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Wiest, R; Reyes, M [Institute for Surgical Technology and Biomechanics, University of Bern, Bern, NA (Switzerland); Bauer, S [Institute for Surgical Technology and Biomechanics, Support Center for Adva, Bern, NA (Switzerland); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: Reproducible definition and quantification of imaging biomarkers is essential. We evaluated a fully automatic MR-based segmentation method by comparing it to manually defined sub-volumes by experienced radiologists in the TCGA-GBM dataset, in terms of sub-volume prognosis and association with VASARI features. Methods: MRI sets of 67 GBM patients were downloaded from the Cancer Imaging archive. GBM sub-compartments were defined manually and automatically using the Brain Tumor Image Analysis (BraTumIA), including necrosis, edema, contrast enhancing and non-enhancing tumor. Spearman’s correlation was used to evaluate the agreement with VASARI features. Prognostic significance was assessed using the C-index. Results: Auto-segmented sub-volumes showed high agreement with manually delineated volumes (range (r): 0.65 – 0.91). Also showed higher correlation with VASARI features (auto r = 0.35, 0.60 and 0.59; manual r = 0.29, 0.50, 0.43, for contrast-enhancing, necrosis and edema, respectively). The contrast-enhancing volume and post-contrast abnormal volume showed the highest C-index (0.73 and 0.72), comparable to manually defined volumes (p = 0.22 and p = 0.07, respectively). The non-enhancing region defined by BraTumIA showed a significantly higher prognostic value (CI = 0.71) than the edema (CI = 0.60), both of which could not be distinguished by manual delineation. Conclusion: BraTumIA tumor sub-compartments showed higher correlation with VASARI data, and equivalent performance in terms of prognosis compared to manual sub-volumes. This method can enable more reproducible definition and quantification of imaging based biomarkers and has a large potential in high-throughput medical imaging research.

  11. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Kupelian, P; Kaprealian, T; Selch, M; Low, D; Pajonk, F; Sheng, K [UCLA, Los Angeles, CA (United States)

    2014-06-15

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α{sub 1} D-β{sub 1}D{sup 2}) + (1-F) × exp(-α{sub 2}D-β{sub 2}D{sup 2}) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α{sub 1}, β{sub 1}, α{sub 2}, β{sub 2})=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment

  12. Searching for Unmodeled Sources Using the Earth Occultation Data from the Fermi GBM

    CERN Document Server

    Rodi, James; Cherry, Michael L; Camero-Arranz, Ascension; Finger, Mark H; Jenke, Peter; Wilson-Hodge, Colleen A; Chaplin, Vandiver

    2011-01-01

    Employing the 12 NaI detectors in the Fermi GBM, the Earth Occultation Technique (EOT) can be used to measure the fluxes of x-ray and gamma-ray sources. Each time a source passes behind the Earth (or emerges from behind the Earth), a step-like feature is produced in the detector count rate. With a predefined catalog of source positions, the times of the occultation steps can be calculated, the individual steps fit, and the fluxes derived. However, in order to find new sources and generate a complete catalog, a method is needed for generating an image of the sky. An imaging algorithm has been developed to generate all-sky images using the GBM data. Here we present imaging results from ~2.5 years of data in the 12-25 keV and 100-300 keV energy bands.

  13. The Successful Synergy of Swift and Fermi/GBM in Magnetars

    Science.gov (United States)

    Kouveliotou, Chryssa

    2011-01-01

    The magnetar rate of discovery has increased dramatically in the last decade. Five sources were discovered in the last three years alone as a result of the very efficient synergy among three X- and .gamma-ray instruments on NASA satellites: the Swift/Burst Alert Telescope (BAT), the Fermi/Gamma ray Burst Monitor (GBM), and the Rossi X-Ray Timing Explorer; RXTE/Proportional Counter Array (PCA). To date, there are approx. 25 magnetar candidates, of which two are (one each) in the Large and Small Magellanic Cloud and the rest reside on the Galactic plane of our Milky Way. I will discuss here the main properties of the Magnetar Population and the common projects that can be achieved with the synergy of Swift and GBM.

  14. The Interplanetary Network Supplement to the Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    CERN Document Server

    Hurley, K; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Svinkin, D S; Briggs, M S; Connaughton, V; Meegan, C; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; von Kienlin, A; Zhang, X; Yamaoka, K; Fukazawa, Y; Hanabata, Y; Ohno, M; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; Del Monte, E; Feroci, M; Marisaldi, M

    2013-01-01

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 393 were observed by at least one other instrument in the 9-spacecraft IPN. Of the 393, the localizations of 146 could be improved by arrival time analysis (or "triangulation"). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.4 arcminutes and 32 degrees, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1 sigma GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 degree systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If ...

  15. Techniques for Targeted Fermi-GBM Follow-Up of Gravitational-Wave Events

    Science.gov (United States)

    Blackburn, L.; Camp, J.; Briggs, M. S.; Connaughton, V.; Jenke, P.; Christensen, N.; Veitch, J.

    2012-01-01

    The Advanced LIGO and Advanced Virgo ground-based gravitational-wave (GW) detectors are projected to come online 2015 2016, reaching a final sensitivity sufficient to observe dozens of binary neutron star mergers per year by 2018. We present a fully-automated, targeted search strategy for prompt gamma-ray counterparts in offline Fermi-GBM data. The multi-detector method makes use of a detailed model response of the instrument, and benefits from time and sky location information derived from the gravitational-wave signal.

  16. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Science.gov (United States)

    Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planagumà, Jesús; Reed, Rolf Kåre; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Rygh, Cecilie Brekke; Chekenya, Martha

    2011-01-01

    Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM) and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  17. Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.

    Directory of Open Access Journals (Sweden)

    Jian Wang

    Full Text Available Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4 or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM and melanoma. Thus, we investigated the mechanism of NG2 mediated malignant progression and its potential as a therapeutic target in clinically relevant GBM and melanoma animal models. Xenografting NG2 overexpressing GBM cell lines resulted in increased growth rate, angiogenesis and vascular permeability compared to control, NG2 negative tumours. The effect of abrogating NG2 function was investigated after intracerebral delivery of lentivirally encoded shRNAs targeting NG2 in patient GBM xenografts as well as in established subcutaneous A375 melanoma tumours. NG2 knockdown reduced melanoma proliferation and increased apoptosis and necrosis. Targeting NG2 in two heterogeneous GBM xenografts significantly reduced tumour growth and oedema levels, angiogenesis and normalised vascular function. Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy.

  18. The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

    Science.gov (United States)

    Urbańska, Kaja; Pająk, Beata; Orzechowski, Arkadiusz; Sokołowska, Justyna; Grodzik, Marta; Sawosz, Ewa; Szmidt, Maciej; Sysa, Paweł

    2015-03-01

    Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation of the intrinsic apoptotic pathway of glioblastoma multiforme (GBM) cells cultured in an in ovo model. Human GBM cells, line U-87, were placed on chicken embryo chorioallantoic membrane. After 8 days, the tumors were divided into three groups: control (non-treated), treated with colloidal AgNPs (40 μg/ml), and placebo (tumors supplemented with vehicle only). At the end of the experiment, all tumors were isolated. Assessment of cell proliferation and cell apoptosis was estimated by histological, immunohistochemical, and Western blot analyses. The results show that AgNPs can influence GBM growth. AgNPs inhibit proliferation of GBM cells and seem to have proapoptotic properties. Although there were statistically significant differences between control and AgNP groups in the AI and the levels of active caspase 9 and active caspase 3, the level of these proteins in GBM cells treated with AgNPs seems to be on the border between the spontaneous apoptosis and the induced. Our results indicate that the antiproliferative properties of silver nanoparticles overwhelm proapoptotic ones. Further research focused on the cytotoxic effect of AgNPs on tumor and normal cells should be conducted.

  19. The InterPlanetary Network Supplement to the Second Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    Science.gov (United States)

    Hurley, K.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Svinkin, D. S.; Pal’shin, V. D.; Briggs, M. S.; Meegan, C.; Connaughton, V.; Goldsten, J.; Boynton, W.; Fellows, C.; Harshman, K.; Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B.; Rau, A.; von Kienlin, A.; Zhang, X.; Yamaoka, K.; Fukazawa, Y.; Ohno, M.; Tashiro, M.; Terada, Y.; Barthelmy, S.; Cline, T.; Gehrels, N.; Cummings, J.; Krimm, H. A.; Smith, D. M.; Del Monte, E.; Feroci, M.; Marisaldi, M.

    2017-04-01

    InterPlanetary Network (IPN) data are presented for the gamma-ray bursts in the second Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 462 bursts in that catalog between 2010 July 12 and 2012 July 11, 428, or 93%, were observed by at least 1 other instrument in the 9-spacecraft IPN. Of the 428, the localizations of 165 could be improved by triangulation. For these bursts, triangulation gives one or more annuli whose half-widths vary between about 2.‧3° and 16°, depending on the peak flux, fluence, time history, arrival direction, and the distance between the spacecraft. We compare the IPN localizations with the GBM 1σ, 2σ, and 3σ error contours and find good agreement between them. The IPN 3σ error boxes have areas between about 8 square arcminutes and 380 square degrees, and are an average of 2500 times smaller than the corresponding GBM 3σ localizations. We identify four bursts in the IPN/GBM sample whose origins were given as “uncertain,” but may in fact be cosmic. This leads to an estimate of over 99% completeness for the GBM catalog.

  20. The Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Stanbro, M.; Briggs, M. S.; Roberts, O.; McBreen, S.; Bhat, N.; Fitzpatrick, G.

    2015-12-01

    We present results from the catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. The first release, in January 2015, provided data on 2700 TGFs. Updates are extending the catalog at a rate of ~800 TGFs per year. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and other Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs). In January 2016 additional data will be released online from correlating these TGFs with sferics detected by the World Wide Lightning Location Network (WWLLN). Maps of sferics in the vicinity of each TGF will be provided, as will the locations and times of sferics found to be associated with TGFs.

  1. Magnetar Twists: Fermi/Gamma ray Burst Monitor (GBM) detection of SGR 1550-5418

    CERN Document Server

    Kaneko, Y; Kouveliotou, C; Ramirez-Ruiz, E; Granot, J; van der Horst, A J; Watts, A L; Finger, M H; Gehrels, N; Pe'er, A; van der Klis, M; von Kienlin, A; Wachter, S; Wilson-Hodge, C A; Woods, P M

    2009-01-01

    SGR 1550-5418 (previously known as AXP 1E 1547.0-5408) went into three active bursting episodes in 2008 October and in 2009 January and March, emitting hundreds of typical Soft Gamma Repeater (SGR) bursts in soft gamma rays. The second episode was especially intense, and our untriggered burst search on Fermi/GBM data (8-1000 keV) revealed ~450 bursts emitted over 24 hours during the peak of this activity. Using the GBM data, we identified a ~150-s-long enhanced persistent emission during 2009 January 22 that exhibited intriguing timing and spectral properties: (i) clear pulsations up to ~110 keV at the spin period of the neutron star (P ~2.07 s, the fastest of all magnetars), (ii) an additional (to a power-law) blackbody component required for the enhanced emission spectra with kT ~17 keV, (iii) pulsed fraction that is strongly energy dependent and highest in the 50-74 keV energy band. A total isotropic-equivalent energy emitted during this enhanced emission is estimated to be 4.3 x 10^{40} ergs. We conclude ...

  2. New Methods for Timing Analysis of Transient Events, Applied to Fermi/GBM Magnetar Bursts

    CERN Document Server

    Huppenkothen, Daniela; Uttley, Phil; van der Horst, Alexander J; van der Klis, Michiel; Kouveliotou, Chryssa; Gogus, Ersin; Granot, Jonathan; Vaughan, Simon; Finger, Mark H

    2013-01-01

    In order to discern the physical nature of many gamma-ray sources in the sky, we must look not only in spectral and spatial dimensions, but also understand their temporal variability. However, timing analysis of sources with a highly transient nature, such as magnetar bursts, is difficult: standard Fourier techniques developed for long-term variability generally observed, for example, from AGN often do not apply. Here, we present newly developed timing methods applicable to transient events of all kinds, and show their successful application to magnetar bursts observed with Fermi/GBM. Magnetars are a prime subject for timing studies, thanks to the detection of quasi-periodicities in magnetar Giant Flares and their potential to help shed light on the structure of neutron stars. Using state-of-the art statistical techniques, we search for quasi-periodicities (QPOs) in a sample of bursts from Soft Gamma Repeater SGR J0501+4516 observed with Fermi/GBM and provide upper limits for potential QPO detections. Additio...

  3. $Fermi$ GBM Observations of V404 Cyg During its 2015 Outburst

    CERN Document Server

    Jenke, P A; Homan, Jeroen; Veres, P; Briggs, M S; Burns, E; Connaughton, V; Finger, M H; Hui, M

    2016-01-01

    V404 Cygni was discovered in 1989 by the $Ginga$ X-ray satellite during its only previously observed X-ray outburst and soon after confirmed as a black hole binary. On June 15, 2015, the Gamma Ray Burst Monitor (GBM) triggered on a new outburst of V404 Cygni. We present 13 days of GBM observations of this latest outburst including Earth occultation flux measurements, spectral and temporal analysis. The Earth occultation fluxes reached 30 Crab with detected emission to 100 keV and determined, via hardness ratios, that the source was in a hard state. At high luminosity, spectral analysis between 8 and 300 keV showed that the electron temperature decreased with increasing luminosity. This is expected if the protons and electrons are in thermal equilibrium during an outburst with the electrons cooled by the Compton scattering of softer seed photons from the disk. However, the implied seed photon temperatures are unusually high, suggesting a contribution from another source, such as the jet. No evidence of state t...

  4. Gravitational wave observations may constrain gamma-ray burst models: the case of GW 150914 - GBM

    CERN Document Server

    Veres, P; Goldstein, A; Mészáros, P; Burns, E; Connaughton, V

    2016-01-01

    The possible short gamma-ray burst (GRB) observed by {\\it Fermi}/GBM in coincidence with the first gravitational wave (GW) detection, offers new ways to test GRB prompt emission models. Gravitational wave observations provide previously unaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW~150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density ($\\sim 10^{-3}$ cm$^{-3}$) and a high Lorentz factor ($\\sim 2000$). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Bl...

  5. Notch- and vitamin D signaling in 1,25(OH)2D3-resistant glioblastoma multiforme (GBM) cell lines.

    Science.gov (United States)

    Reichrath, Sandra; Müller, Cornelia S L; Gleissner, Beate; Pfreundschuh, Michael; Vogt, Thomas; Reichrath, Jörg

    2010-07-01

    Recently, an important role of Notch activation for Ras-induced transformation of glial cells and for glioma growth and survival has been demonstrated. It was concluded that activation of Notch-signaling may represent a new target for glioblastoma multiforme (GBM) therapy. We now analyzed five GBM cell lines (Tx3095, Tx3868, U87, U118, U373) for key components of Notch-signaling pathways (Notch-1, Notch-2, Notch-3, Notch-4, Delta-like 1, Delta-like 3, Delta-like 4, Jagged-1, Jagged-2) using conventional RT-PCR. We found that some components (Notch-1, Notch-2, Notch-4, Jagged-1) were consistently expressed in all cell lines analyzed while, in contrast, other key components of Notch-signaling were differentially expressed. Notch-3 was expressed in three out of five cell lines (in U87, U118 and U373), but was missing in Tx3095 and Tx3868 cells. Jagged-2 was expressed in U87, U373 and Tx3868, but not in U118 or Tx3095 cells. Delta-like 1 and Delta-like 3 were not detected in Tx3905 cells, but in all other cell lines. RNA for Delta-like 4 was only found in U373 and Tx3868 GBM cell lines. Treating GBM cell lines with 1,25(OH)2D3 (10(-6), 10(-8), and 10(-10) M), the biologically active form of vitamin D, did not result in significant dose- or time-dependent antiproliferative effects, indicating that GBM cell lines are resistant against the antiproliferative activity of 1,25(OH)2D3. In vitro treatment of GBM cells with 1,25(OH)2D3 did not result in a modulation of the expression of key components of the Notch-signaling pathway. Treatment with HDAC-inhibitor TSA or DNA-methyltransferase inhibitor 5-aza exerted dose- and time-dependent antiproliferative effects on GBM cell lines. We asked the question whether the resistance against 1,25(OH)2D3 could be restored by co-treatment with TSA or 5-aza. However, combination therapy with 1,25(OH)2D3 and TSA or 5-aza did not result in enhanced antiproliferative effects as compared to treatment with TSA or 5-aza alone. In contrast

  6. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    Directory of Open Access Journals (Sweden)

    Monticone Massimiliano

    2012-08-01

    Full Text Available Abstract Background Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type or highly diffuse single tumor cell infiltration (HD-type. Methods We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM. Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Results Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. Conclusions This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  7. Validation of an automated method for compounding monoclonal antibody patient doses: case studies of Avastin (bevacizumab), Remicade (infliximab) and Herceptin (trastuzumab).

    Science.gov (United States)

    Peters, Bas J M; Capelle, Martinus A H; Arvinte, Tudor; van de Garde, Ewoudt M W

    2013-01-01

    Automation robots have recently come to the market as an alternative for manual compounding of drugs for intravenous administration. Our aim was to assess whether robotic compounding can be performed with monoclonal antibodies (mAbs) without influencing the aggregation state of the proteins. Three frequently used mAbs were studied: infliximab (Remicade, Janssen Biotech) and trastuzumab (Herceptin, Roche) in lyophilised form, and bevacizumab (Avastin, Roche) as a liquid formulation stored at 2°C to 8°C. The effects of different procedures to prepare the patient doses on antibody aggregation were evaluated. Remicade and Herceptin were reconstituted both manually and by a robotic arm (i.v.STATION, Health Robotics). Additionally, the influence of vigorous shaking during reconstitution was investigated. The effects of rapid aspiration and dispensing on antibody aggregation were investigated for all three mAbs. Aggregation state was assessed by UV-Vis absorbance, 90° light scatter, fluorescence spectroscopy, Nile red fluorescence microscopy, and field flow fractionation without cross and focus flow. Robotic reconstituted samples showed similar findings compared with manual reconstitution if performed exactly according to the summary of product characteristics (SPC). Vials that were vigorously shaken showed a significant increase in aggregates. Similarly, rapid aspiration/dispense cycles resulted in a strong increase in the number and sizes of aggregates for all three mAbs; this result was observed after just one rapid aspiration/dispense cycle. Our study showed that robotic compounding of mAbs is feasible if the robot is exactly programmed according to the SPC, indicating that robotic compounding can be used to achieve reproducible high-quality compounding for delicate formulations.

  8. Swift/BAT and Fermi/GBM observations of SGR J1935+2154 bursts

    Science.gov (United States)

    Lin, Lin

    2016-07-01

    SGR J1935+2154 is a new member of the magnetar family. It was discovered from a short burst which triggered Swift/BAT on 2014 July 5. In 2015 February, the source was detected in the burst active episode again which lasted for about 11 days. We searched for magnetar burst using Bayesian Blocks method through Swift/BAT and Fermi/GBM observations, and totally found 27 events including 3 in 2014 and 24 in 2015. In this talk we will present the result of our detailed analysis of the temporal and spectral properties of these short bursts, and briefly discuss the connection between burst activity and the persistent emission of the source.

  9. DISTRIBUTION OF GBM HEPARAN-SULFATE PROTEOGLYCAN CORE PROTEIN AND SIDE-CHAINS IN HUMAN GLOMERULAR-DISEASES

    NARCIS (Netherlands)

    VANDENBORN, J; VANDENHEUVEL, LPWJ; BAKKER, MAH; VEERKAMP, JH; ASSMANN, KJM; WEENING, JJ; BERDEN, JHM

    1993-01-01

    Using monoclonal antibodies (mAbs) recognizing either the core protein or the heparan sulfate (HS) side chain of human GBM heparan sulfate proteoglycan (HSPG), we investigated their glomerular distribution on cryostat sections of human kidney tissues. The study involved 95 biopsies comprising twelve

  10. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    CERN Document Server

    Racusin, J L; Goldstein, A; Connaughton, V; Wilson-Hodge, C A; Jenke, P; Blackburn, L; Briggs, M S; Broida, J; Camp, J; Christensen, N; Hui, C M; Littenberg, T; Shawhan, P; Singer, L; Veitch, J; Bhat, P N; Cleveland, W; Fitzpatrick, G; Gibby, M H; von Kienlin, A; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O J; Stanbro, M; Veres, P; Zhang, B -B; Ackermann, M; Albert, A; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Bruel, P; Buson, S; Caliandro, G A; Cameron, R A; Caputo, R; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Charles, E; Chiang, J; Ciprini, S; Costanza, F; Cuoco, A; Cutini, S; D'Ammando, F; de Palma, F; Desiante, R; Digel, S W; Di Lalla, N; Di Mauro, M; Di Venere, L; Drell, P S; Favuzzi, C; Ferrara, E C; Focke, W B; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Gill, R; Giroletti, M; Glanzman, T; Granot, J; Green, D; Grove, J E; Guillemot, L; Guiriec, S; Harding, A K; Jogler, T; Johannesson, G; Kamae, T; Kensei, S; Kocevski, D; Kuss, M; Larsson, S; Latronico, L; Li, J; Longo, F; Loparco, F; Lubrano, P; Magill, J D; Maldera, S; Malyshev, D; McEnery, J E; Michelson, P F; Mizuno, T; Morselli, A; Moskalenko, I V; Negro, M; Nuss, E; Omodei, N; Orienti, M; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Principe, G; Raino, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Parkinson, P M Saz; Scargle, J D; Sgro, C; Simone, D; Siskind, E J; Smith, D A; Spada, F; Spinelli, P; Suson, D J; Tajima, H; Thayer, J B; Torres, D F; Troja, E; Uchiyama, Y; Vianello, G; Wood, K S; Wood, M

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, dif- ferences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  11. MAXIMIZATION OF DNA DAMAGE TO MGMT(+ EGFR(+ GBM CELLS USING OPTIMAL COMBINATION OF TEMOZOLOMIDE-ANTI EGFR MONOCLONAL ANTIBODY NIMOTUZUMAB

    Directory of Open Access Journals (Sweden)

    M. A. M. Inggas

    2015-09-01

    Full Text Available Background: Glioblastoma multiforme (GBM is the most aggressive primary brain tumor in adultswith dismal prognosis due to the unavailability of an effective therapy. Up to now, there had been no definitive studies published on EGFR inhibition therapy as a chemosensitizer for GBM therapy using Temozolomide (TMZ. This study aims to reveal the most effective method and timing to administer TMZ-anti EGFR targeted therapy which causes maximal DNA damage on GBM cells.Methods: Various regimens of anti EGFR monoclonal antibody Nimotuzumab (NMZ was administered in different combinations with TMZ, performed on U87MG MGMT(+ EGFR(+ cells. The effectiveness of the combinations were evaluated by measuring yH2AX levels which reflects the degree of DNA damage. One-way Anova and LSD tests were performed to determine the effects of each treatment with p<0.05. Results and discussion: the mean SD of yH2AX of each treatment was: 11,90±1,25 for the control group; 29.33±1.91 for NMZ alone; 28.13±1.58 for TMZ alone; 41.53±3.51 for concurrent use; 35.67 ±2.65 for NMZ after 24 hours TMZ; 31.87±2.94 for NMZ after 48 hours TMZ; 39.57±4.2 for TMZ after 24 hours NMZ; and 35.93 ±3.56 for TMZ after 48 hours NMZ. The administration of TMZ concurrent with or after 24 hours NMZ gives the highest amount of DNA damage to GBM cells. Conclusion: The administration of Nimotuzumab targeted therapy up to 24 hours before Temozolomide chemotherapy has been proven to be effective in maximizing the amount of DNA damage done to GBM cells in vitro. 

  12. GBM Monitoring of Cyg X-1 During the Recent State Transition

    CERN Document Server

    Case, G L; Cherry, M L; Camero-Arranz, A; Finger, M; Jenke, P; Wilson-Hodge, C A; Chaplin, V

    2011-01-01

    Cygnus X-1 is a high-mass x-ray binary with a black hole compact object. It is normally extremely bright in hard x-rays and low energy gamma rays and resides in the canonical hard spectral state. Recently, however, Cyg X-1 made a transition to the canonical soft state, with a rise in the soft x-ray flux and a decrease in the flux in the hard x-ray and low energy gamma-ray energy bands. We have been using the Gamma-Ray Burst Monitor on Fermi to monitor the fluxes of a number of sources in the 8--1000 keV energy range, including Cyg X-1. We present light curves of Cyg X-1 showing the flux decrease in hard x-ray and low energy gamma-ray energy bands during the state transition as well as the several long flares observed in these higher energies during the soft state. We also present preliminary spectra from GBM for the pre-transition state, showing the spectral evolution to the soft state, and the post-transition state.

  13. Restriction spectrum imaging of bevacizumab-related necrosis in a patient with GBM

    Directory of Open Access Journals (Sweden)

    Nikdokht eFarid

    2013-09-01

    Full Text Available Importance:With the increasing use of antiangiogenic agents in the treatment of high grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with histopathologic validation, confirming that this region of restricted diffusion represents necrosis and not viable tumor. Observations:We present a case report of a 52-year-old man with GBM treated with temozolomide, radiation, and concurrent bevacizumab following gross total resection. The patient underwent sequential MRI's which included restriction-spectrum imaging (RSI, an advanced diffusion-weighted imaging (DWI technique, and MR perfusion. Following surgery, the patient developed an area of restricted diffusion on RSI which became larger and more confluent over the next several months. Marked signal intensity on RSI and very low cerebral blood volume (CBV on MR perfusion led us to favor bevacizumab-related necrosis over recurrent tumor. Subsequent histopathologic evaluation confirmed coagulative necrosis.Conclusions and Relevance:Our report increases the number of pathologically-proven cases of bevacizumab-related necrosis in the literature from three to four. Furthermore, our case demonstrates this phenomenon on RSI, which has been shown to have good sensitivity to restricted diffusion.

  14. GBM Volumetry using the 3D Slicer Medical Image Computing Platform

    Science.gov (United States)

    Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra J.; Nimsky, Christopher; Kikinis, Ron

    2013-01-01

    Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – a free platform for biomedical research – provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23% and a Hausdorff Distance of 2.32 ± 5.23 mm. PMID:23455483

  15. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

    CERN Document Server

    Gruber, David; von Ahlefeld, Victoria Weller; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Byrne, Dave; Cleveland, William H; Connaughton, Valerie; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty M; Greiner, Jochen; Guiriec, Sylvain; van der Horst, Alexander J; von Kienlin, Andreas; Kouveliotou, Chryssa; Layden, Emily; Lin, Lin; Meegan, Charles A; McGlynn, Sinéad; Paciesas, William S; Pelassa, Véronique; Preece, Robert D; Rau, Arne; Wilson-Hodge, Colleen A; Xiong, Shaolin; Yu, Hoi-Fung

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  16. Testing the anisotropy in the angular distribution of $Fermi$/GBM gamma-ray bursts

    CERN Document Server

    Tarnopolski, Mariusz

    2015-01-01

    Gamma-ray bursts (GRBs) were confirmed to be of extragalactic origin due to their isotropic angular distribution, combined with the fact that they exhibited an intensity distribution that deviated strongly from the $-3/2$ power law. This finding was later confirmed with the first redshift, equal to at least $z=0.835$, measured for GRB970508. Despite this result, the data from $CGRO$/BATSE and $Swift$/BAT indicate that long GRBs are indeed distributed isotropically, but the distribution of short GRBs is anisotropic. $Fermi$/GBM has detected 1669 GRBs up to date, and their sky distribution is examined in this paper. A number of statistical tests is applied: nearest neighbour analysis, fractal dimension, dipole and quadrupole moments of the distribution function decomposed into spherical harmonics, binomial test, and the two point angular correlation function. Monte Carlo benchmark testing of each test is performed in order to evaluate its reliability. It is found that short GRBs are distributed anisotropically ...

  17. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

    Science.gov (United States)

    Raizer, J. J.; Giglio, P.; Hu, J.; Groves, M.; Merrell, R.; Conrad, C.; Phuphanich, S.; Puduvalli, V. K.; Loghin, M.; Paleologos, N.; Yuan, Y.; Liu, D.; Rademaker, A.; Yung, W. K.; Vaillant, B.; Rudnick, J.; Chamberlain, M.; Vick, N.; Grimm, S.; Tremont-Lukats, I. W.; De Groot, J.; Aldape, K.; Gilbert, M. R.

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29–75) and median KPS was 90 (70–100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2–47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  18. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Wilson-Hodge, Colleen A; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Jenke, Peter; Chaplin, Vandiver; Beklen, Elif; Finger, Mark; Bhat, Narayan; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2012-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 102 sources, including 41 low-mass X-ray binary/neutron star systems, 33 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.

  19. HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.

    Science.gov (United States)

    Booth, Laurence; Roberts, Jane L; Conley, Adam; Cruickshanks, Nichola; Ridder, Thomas; Grant, Steven; Poklepovic, Andrew; Dent, Paul

    2014-03-01

    The present studies determined whether the antibiotic salinomycin interacted with HDAC inhibitors to kill primary human GBM cells. Regardless of PTEN, ERBB1, or p53 mutational status salinomycin interacted with HDAC inhibitors in a synergistic fashion to kill GBM cells. Inhibition of CD95/Caspase 8 or of CD95/RIP-1/AIF signaling suppressed killing by the drug combination. Salinomycin increased the levels of autophagosomes that correlated with increased p62 and LC3II levels; valproate co-treatment correlated with reduced LC3II and p62 expression, and increased caspase 3 cleavage. Molecular inhibition of autophagosome formation was protective against drug exposure. The drug combination enhanced eIF2α phosphorylation and decreased expression of MCL-1 and phosphorylation of mTOR and p70 S6K. Activation of p70 S6K or mTOR promoted cell survival in the face of combined drug exposure. Overexpression of BCL-XL or c-FLIP-s was protective. Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.

  20. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  1. Improved limits on sterile neutrino dark matter from full-sky observations by the Fermi-GBM

    CERN Document Server

    Horiuchi, Shunsaku; Gaskins, Jennifer M; Smith, Miles; Preece, Robert

    2015-01-01

    For the first time, we use the Gamma-ray Burst Monitor (GBM) on-board the Fermi satellite to search for sterile neutrino decay lines in the energy range 10-25 keV corresponding to sterile neutrino mass range 20-50 keV. This energy range has been out of reach of traditional X-ray satellites such as Chandra, Suzaku, XMM-Newton, and gamma-ray satellites such as INTEGRAL. Furthermore, the extremely wide field of view of the GBM opens a large fraction of the Milky Way dark matter halo to be probed. We start with 1601 days worth of GBM data, implement stringent data cuts, and perform two simple line search analyses on the reduced data: in the first, the line flux is limited without background modeling, and in the second, the background is modeled as a power-law. We find no significant excess lines in both our searches. We set new limits on sterile neutrino mixing angles, improving on previous limits by approximately an order of magnitude. Better understanding of detector and astrophysical backgrounds, as well as de...

  2. A Novel GBM Saliency Detection Model Using Multi-Channel MRI.

    Directory of Open Access Journals (Sweden)

    Subhashis Banerjee

    Full Text Available The automatic computerized detection of regions of interest (ROI is an important step in the process of medical image processing and analysis. The reasons are many, and include an increasing amount of available medical imaging data, existence of inter-observer and inter-scanner variability, and to improve the accuracy in automatic detection in order to assist doctors in diagnosing faster and on time. A novel algorithm, based on visual saliency, is developed here for the identification of tumor regions from MR images of the brain. The GBM saliency detection model is designed by taking cue from the concept of visual saliency in natural scenes. A visually salient region is typically rare in an image, and contains highly discriminating information, with attention getting immediately focused upon it. Although color is typically considered as the most important feature in a bottom-up saliency detection model, we circumvent this issue in the inherently gray scale MR framework. We develop a novel pseudo-coloring scheme, based on the three MRI sequences, viz. FLAIR, T2 and T1C (contrast enhanced with Gadolinium. A bottom-up strategy, based on a new pseudo-color distance and spatial distance between image patches, is defined for highlighting the salient regions in the image. This multi-channel representation of the image and saliency detection model help in automatically and quickly isolating the tumor region, for subsequent delineation, as is necessary in medical diagnosis. The effectiveness of the proposed model is evaluated on MRI of 80 subjects from the BRATS database in terms of the saliency map values. Using ground truth of the tumor regions for both high- and low- grade gliomas, the results are compared with four highly referred saliency detection models from literature. In all cases the AUC scores from the ROC analysis are found to be more than 0.999 ± 0.001 over different tumor grades, sizes and positions.

  3. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

    Directory of Open Access Journals (Sweden)

    Nameeta Shah

    Full Text Available O⁶-methylguanine DNA-methyltransferase (MGMT promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (CpG dinucleotide methylation across the entire MGMT promoter and to correlate individual CpG site methylation patterns to mRNA expression, protein expression, and progression-free survival. To best identify the specific MGMT promoter region most predictive of gene silencing and response to therapy, we determined the methylation status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients using quantitative bisulfite sequencing. We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival. Using this data, we propose a new classification scheme utilizing methylation data from across the entire promoter and show that an analysis based on this approach, which we call 3R classification, is predictive of progression-free survival (HR  = 5.23, 95% CI [2.089-13.097], p<0.0001. To adapt this approach to the clinical setting, we used a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA test based on the 3R classification and show that this test is both feasible in the clinical setting and predictive of progression free survival (HR  = 3.076, 95% CI [1.301-7.27], p = 0.007. We discuss the potential advantages of a test based on this promoter-wide analysis and compare it to the commonly used methylation-specific PCR test. Further prospective validation of these two methods in a large independent patient cohort will be needed to confirm the added value of promoter wide analysis of MGMT methylation in the clinical

  4. The Problem with Briefs, in Brief

    Science.gov (United States)

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  5. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.

    Science.gov (United States)

    Chen, Chien-Min; Syu, Jhih-Pu; Way, Tzong-Der; Huang, Li-Jiau; Kuo, Sheng-Chu; Lin, Chung-Tien; Lin, Chih-Li

    2015-11-01

    Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti‑glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti‑proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell‑cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy‑mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B‑induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken together, the present results provide molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug‑resistant glioblastoma cells to the chemotherapeutic agent TMZ.

  6. Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.

    Science.gov (United States)

    Chou, Yu-Cheng; Chang, Meng-Ya; Wang, Mei-Jen; Liu, Hsin-Chung; Chang, Shu-Jen; Harnod, Tomor; Hung, Chih-Huang; Lee, Hsu-Tung; Shen, Chiung-Chyi; Chung, Jing-Gung

    2017-01-01

    Glioblastoma is the most common and aggressive primary brain malignancy. Phenethyl isothiocyanate (PEITC), a member of the isothiocyanate family, can induce apoptosis in many human cancer cells. Our previous study disclosed that PEITC induces apoptosis through the extrinsic pathway, dysfunction of mitochondria, reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress, and intrinsic (mitochondrial) pathway in human brain glioblastoma multiforme (GBM) 8401 cells. To the best of our knowledge, we first investigated the effects of PEITC on the genetic levels of GBM 8401 cells in vitro. PEITC may induce G0/G1 cell-cycle arrest through affecting the proteins such as cdk2, cyclin E, and p21 in GBM 8401 cells. Many genes associated with cell-cycle regulation of GBM 8401 cells were changed after PEITC treatment: 48 genes were upregulated and 118 were downregulated. The cell-division cycle protein 20 (CDC20), Budding uninhibited by benzimidazole 1 homolog beta (BUB1B), and cyclin B1 were downregulated, and clusterin was upregulated in GBM 8401 cells treated with PEITC. These changes of gene expression can provide the effects of PEITC on the genetic levels and potential biomarkers for glioblastoma. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 176-187, 2017.

  7. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Jenke, P; Case, Gary L; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Chaplin, Vandiver; Beklen, Elif; Finger, Mark H; Bhat, Narayana; Briggs, Michael S; Connaughto, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2013-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi Gamma-ray Space Telescope has been providing continuous data to the astronomical community since 2008 August 12. We will present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. Although the occultation technique is in principle quite simple, in practice there are many complications including the dynamic instrument response, source confusion, and scattering in the Earth's atmosphere, which will be described. We detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to ot...

  8. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    CERN Document Server

    Hynes, R I; Baum, Z A; Hsu, C -C; Cherry, M L; Scaringi, S

    2016-01-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal ...

  9. First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

    CERN Document Server

    Case, Gary L; Rodi, James C; Jenke, Peter; Wilson-Hodge, Colleen A; Finger, Mark H; Meegan, Charles A; Camero-Arranz, Ascencion; Beklen, Elif; Bhat, P Narayan; Briggs, Michael S; Chaplin, Vandiver; Connaughton, Valerie; Paciesas, William S; Preece, Robert; Kippen, R Marc; von Kienlin, Andreas; Griener, Jochen

    2010-01-01

    The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transien...

  10. Is surgical spinal decompression for supratentorial GBM symptomatic drop down metastasis warranted? A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Muhammad Babar Khan

    2014-01-01

    Full Text Available Background: Symptomatic spinal metastasis from an intracranial primary glioblastoma multiforme (GBM is very rare. Our literature search identified a total of 42 such patients of which 11 were treated with surgical decompression for spinal metastasis with only one such report from the pediatric age group. Previous studies have reported variable outcomes after surgical management. Case Description: We report the case of a 16-year-old boy who underwent surgical spinal decompression for spinal metastasis after intracranial GBM. The patient regained motor and autonomic function following surgery and reported improvement in pain. We also present findings from a literature review using the PubMed database from 1985 to June 2013 on this subject and compare radiation therapy with surgical decompression as palliative modalities in such patients. Conclusion: There are no evidence-based guidelines available on the subject and no treatment regimen has yet demonstrated survival benefit in these patients. Surgical decompression may be a better option for patients with focal resectable lesions and who are medically stable to tolerate the procedure.

  11. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Science.gov (United States)

    Bertagnolli, Nicolas M; Drake, Justin A; Tennessen, Jason M; Alter, Orly

    2013-01-01

    To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD) to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM) or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  12. THREE YEARS OF FERMI GBM EARTH OCCULTATION MONITORING: OBSERVATIONS OF HARD X-RAY/SOFT GAMMA-RAY SOURCES

    Energy Technology Data Exchange (ETDEWEB)

    Wilson-Hodge, Colleen A.; Jenke, Peter [ZP 12 Astrophysics Office, NASA Marshall Space Flight Center, Huntsville, AL 35812 (United States); Case, Gary L.; Cherry, Michael L.; Rodi, James [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803 (United States); Camero-Arranz, Ascension [Instituto de Ciencias del Espacio (IEEC-CSIC), Campus UAB, Torre C5, 2a planta, 08193 Barcelona (Spain); Chaplin, Vandiver; Bhat, Narayan; Briggs, Michael S.; Connaughton, Valerie; Preece, Robert [Physics Department, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Beklen, Elif [Physics Department, Suleyman Demirel University, 32260 Isparta (Turkey); Finger, Mark; Paciesas, William S. [Universities Space Research Association, Huntsville, AL 35805 (United States); Greiner, Jochen; Meegan, Charles A.; Von Kienlin, Andreas [Max-Planck Institut fuer Extraterrestische Physik, D-85748 Garching (Germany); Kippen, R. Marc [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2012-08-01

    The Gamma-ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper, we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, and 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found online.

  13. Gravitational-wave Observations May Constrain Gamma-Ray Burst Models: The Case of GW150914-GBM

    Science.gov (United States)

    Veres, P.; Preece, R. D.; Goldstein, A.; Mészáros, P.; Burns, E.; Connaughton, V.

    2016-08-01

    The possible short gamma-ray burst (GRB) observed by Fermi/GBM in coincidence with the first gravitational-wave (GW) detection offers new ways to test GRB prompt emission models. GW observations provide previously inaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW 150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however, have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density (˜10-3 cm-3) and a high Lorentz factor (˜2000). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Blandford-Znajek model. If future joint observations confirm the GW-short-GRB association we can provide similar but more detailed tests for prompt emission models.

  14. AMAS Robotics Seminar Brief

    Science.gov (United States)

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  15. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM

    Science.gov (United States)

    Crawford, Forrest W.; Khayal, Inas S.; McGue, Colleen; Saraswathy, Suja; Pirzkall, Andrea; Cha, Soonmee; Lamborn, Kathleen R.; Chang, Susan M.; Berger, Mitchel S.

    2010-01-01

    Glioblastoma Multiforme (GBM) are heterogeneous lesions, both in terms of their appearance on anatomic images and their response to therapy. The goal of this study was to evaluate the prognostic value of parameters derived from physiological and metabolic images of these lesions. Fifty-six patients with GBM were scanned immediately before surgical resection using conventional anatomical MR imaging and, where possible, perfusion-weighted imaging, diffusion-weighted imaging, and proton MR spectroscopic imaging. The median survival time was 517 days, with 15 patients censored. Absolute anatomic lesion volumes were not associated with survival but patients for whom the combined volume of contrast enhancement and necrosis was a large percentage of the T2 hyperintense lesion had relatively poor survival. Other volumetric parameters linked with less favorable survival were the volume of the region with elevated choline to N-acetylaspartate index (CNI) and the volume within the T2 lesion that had apparent diffusion coefficient (ADC) less than 1.5 times that in white matter. Intensity parameters associated with survival were the maximum and the sum of levels of lactate and of lipid within the CNI lesion, as well as the magnitude of the 10th percentile of the normalized ADC within the contrast-enhancing lesion. Patients whose imaging parameters indicating that lesions with a relatively large percentage with breakdown of the blood brain barrier or necrosis, large regions with abnormal metabolism or areas with restricted diffusion have relatively poor survival. These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials. PMID:19009235

  16. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Directory of Open Access Journals (Sweden)

    Nicolas M Bertagnolli

    Full Text Available To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  17. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.

    Directory of Open Access Journals (Sweden)

    Vikas Chandra

    Full Text Available Hedgehog (Hh signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM, a lethal malignancy of the central nervous system (CNS. By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7 between GLI1 and PTCH1 mRNA expression--as a hallmark of the canonical Hh-pathway activity in this malignancy. GLI1 mRNA expression varied in 3 orders of magnitude among the GBM patients of the same cohort showing a single continuous distribution-unlike the discrete high/low-GLI1 mRNA expressing clusters of medulloblastoma (MB. When compared with MB as a reference, the median GLI1 mRNA expression in GBM appeared 14.8 fold lower than that of the "high-Hh" cluster of MB but 5.6 fold higher than that of the "low-Hh" cluster of MB. Next, we demonstrated statistically significant up- and down-regulation of GLI1 mRNA expressions in GBM patient-derived low-passage neurospheres in vitro by sonic hedgehog ligand-enriched conditioned media (shh-CM and by Hh-inhibitor drug vismodegib respectively. We also showed clinically achievable dose (50 μM of vismodegib alone to be sufficient to induce apoptosis and cell cycle arrest in these low-passage GBM neurospheres in vitro. Vismodegib showed an effect on the neurospheres, both by down-regulating GLI1 mRNA expression and by inducing apoptosis/cell cycle arrest, irrespective of their relative endogenous levels of GLI1 mRNA expression. We conclude from our study that this single continuous distribution pattern of GLI1 mRNA expression technically puts almost all GBM patients in a single group rather than discrete high- or low-clusters in terms of Hh-pathway activity. That is suggestive of therapies with Hh-pathway inhibitor drugs in this malignancy without a need for further stratification of patients on the basis of relative levels of Hh-pathway activity among them.

  18. Mississippi: State Policy Brief

    Science.gov (United States)

    Corbett, Julie

    2014-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  19. TU-CD-BRB-04: Automated Radiomic Features Complement the Prognostic Value of VASARI in the TCGA-GBM Dataset

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez, E Rios [Dana-Farber Cancer Institute | Harvard Medical School, Boston, MA (United States); Narayan, V [Dana-Farber Cancer Institute, Brigham and Womens Hospital, Harvard Medic, Boston, MA (United States); Grossmann, P [Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (United States); Dunn, W; Gutman, D [Emory University School of Medicine, Atlanta, GA (United States); Aerts, H [Dana-Farber/Brigham Womens Cancer Center, Boston, MA (United States)

    2015-06-15

    Purpose: To compare the complementary prognostic value of automated Radiomic features to that of radiologist-annotated VASARI features in TCGA-GBM MRI dataset. Methods: For 96 GBM patients, pre-operative MRI images were obtained from The Cancer Imaging Archive. The abnormal tumor bulks were manually defined on post-contrast T1w images. The contrast-enhancing and necrotic regions were segmented using FAST. From these sub-volumes and the total abnormal tumor bulk, a set of Radiomic features quantifying phenotypic differences based on the tumor intensity, shape and texture, were extracted from the post-contrast T1w images. Minimum-redundancy-maximum-relevance (MRMR) was used to identify the most informative Radiomic, VASARI and combined Radiomic-VASARI features in 70% of the dataset (training-set). Multivariate Cox-proportional hazards models were evaluated in 30% of the dataset (validation-set) using the C-index for OS. A bootstrap procedure was used to assess significance while comparing the C-Indices of the different models. Results: Overall, the Radiomic features showed a moderate correlation with the radiologist-annotated VASARI features (r = −0.37 – 0.49); however that correlation was stronger for the Tumor Diameter and Proportion of Necrosis VASARI features (r = −0.71 – 0.69). After MRMR feature selection, the best-performing Radiomic, VASARI, and Radiomic-VASARI Cox-PH models showed a validation C-index of 0.56 (p = NS), 0.58 (p = NS) and 0.65 (p = 0.01), respectively. The combined Radiomic-VASARI model C-index was significantly higher than that obtained from either the Radiomic or VASARI model alone (p = <0.001). Conclusion: Quantitative volumetric and textural Radiomic features complement the qualitative and semi-quantitative annotated VASARI feature set. The prognostic value of informative qualitative VASARI features such as Eloquent Brain and Multifocality is increased with the addition of quantitative volumetric and textural features from the

  20. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

    Directory of Open Access Journals (Sweden)

    Yajuan Li

    Full Text Available Previously we have shown that kallikreins (klks play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1 gene was transduced into murine MSCs using a retroviral vector to generate a stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected to anti-GBM induced nephritis were transplanted with 10(6 hKLK1-MSCs and hKLK1 expression was confirmed in the kidneys. Compared with vector-MSCs injected mice, the hKLK1-MSCs treated mice showed significantly reduced proteinuria, blood urea nitrogen (BUN and ameliorated renal pathology. Using the same strategy, we treated lupus-prone B6.Sle1.Sle3 bicongenic mice with hKLK1-MSCs and demonstrated that hKLK1-MSCs delivery also attenuated lupus nephritis. Mechanistically, hKLK1-MSCs reduced macrophage and T-lymphocyte infiltration into the kidney by suppressing the expression of inflammation cytokines. Moreover, hKLK1 transduced MSCs were more resistant to oxidative stress-induced apoptosis. These findings advance genetically modified MSCs as potential gene delivery tools for targeting therapeutic agents to the kidneys in order to modulate inflammation and oxidative stress in lupus nephritis.

  1. Earth Occultation Imaging Applied to BATSE -- Application to a Combined BATSE-GBM Survey of the Hard X-Ray Sky

    CERN Document Server

    Zhang, Yuan; Case, Gary; Ling, James; Wheaton, William

    2013-01-01

    A combined BATSE-GBM hard X-ray catalog is presented based on Earth Occultation Imaging applied to a reanalysis of BATSE data. An imaging approach has been developed for the reanalysis of Earth Occultation analysis of BATSE data. The standard occultation analysis depends on a predetermined catalog of potential sources, so that a real source not present in the catalog may induce systematic errors when source counts associated with an uncatalogued source are incorrectly attributed to catalog sources. The goal of the imaging analysis is to find a complete set of hard X-ray sources, including sources not in the original BATSE occultation catalog. Using the imaging technique, we have identified 15 known sources and 17 unidentified sources and added them to the BATSE occultation catalog. The resulting expanded BATSE catalog of sources observed during 1991-2000 is compared to the ongoing GBM survey.

  2. Fermi Guest Investigator Program Cycle 2 Project Final Report Albedo Polarimetry of Gamma-Ray Bursts and Solar Flares with GBM

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Richard Marc [Los Alamos National Laboratory

    2012-08-27

    Several key properties of GRBs remain poorly understood and are difficult or even impossible to infer with the information currently being collected. Polarization measurements will probe the precise nature of the central engine. For solar flares, high-energy polarization measurements are expected to be useful in determining the beaming (or directivity) of solar flare electrons - a quantity that may provide important clues about electron acceleration and transport. We propose to investigate the viability of using the Fermi Gamma-ray Burst Monitor (GBM) to measure the polarization of GRBs and solar flares using the albedo photon flux. This approach was previously developed for use with BATSE data. We will conduct a careful study of this technique using a modified version of the GRESS simulation tools developed by the GBM team.

  3. Epidermal growth factor receptor (EGFR mutation status and Rad51 determine the response of glioblastoma (GBM to multimodality therapy with cetuximab, temozolomide and radiation

    Directory of Open Access Journals (Sweden)

    Phyllis Rachelle Wachsberger

    2013-02-01

    Full Text Available Purpose: EGFR amplification and mutation (i.e., EGFRvIII are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulates response to multimodality treatment with cetuximab, an anti-EGFR inhibitor, the chemotherapeutic agent, temozolamide (TMZ and radiation therapy (RT Methods and Materials: In vitro and in vivo experiments were performed on two isogenic U87 GBM cell lines: one overexpressing wildtype EGFR (U87wtEGFR and the other overexpressing EGFRvIII (U87EGFRvIII. Results: Xenografts harboring EGFRvIII were more sensitive to TMZ alone and TMZ in combination with RT and/or cetuximab than xenografts expressing wtEGFR. In vitro experiments demonstrated that U87EGFRvIII-expressing tumors appear to harbor defective DNA homologous recombination repair in the form of Rad51 processing, Conclusions: The difference in sensitivity between EGFR-expressing and EGFRvIII-expressing tumors to combined modality treatment may help in the future tailoring of GBM therapy to subsets of patients expressing more or less of the EGFR mutant.

  4. Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

    Directory of Open Access Journals (Sweden)

    Ravi D. Rao

    2005-10-01

    Full Text Available Elevated epidermal growth factor receptor (EGFR and mammalian target of rapamycin (mTOR signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM, which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target these protein kinases have been evaluated in multiple clinical trials for cancer patients, including those with GBM. Here we have examined the cellular and molecular effects of a combined kinase inhibition of mTOR (rapamycin and EGFR (EKI-785 in U87 and U251 GBM cells. Simultaneous treatment with rapamycin and EKI-785 results in synergistic antiproliferative as well as proapoptotic effects. At a molecular level, rapamycin alone significantly decreases S6 phosphorylation, whereas EKI-785 alone promotes substantially reduced signal transducer and activator of transcription (STAT3 phosphorylation. Treatment with rapamycin alone also increases Akt phosphorylation on Ser-473, but this effect is blocked by a simultaneous administration of EKI-785. Individually, EKI-785 diminishes while rapamycin promotes the binding of the translation inhibitor eukaryotic initiation factor 4E binding protein (4EBP1 to the eukaryotic translation initiation factor 4E (eIF4E. In spite of these opposing effects, the highest level of 4EBP1-eIF4E binding occurs with the combination of the two inhibitors. These results indicate that the inhibition of EGFR and mTOR has distinct as well as common signaling consequences and provides a molecular rationale forthe synergistic antitumor effects of EKI-785 and rapamycin administration.

  5. Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome

    Directory of Open Access Journals (Sweden)

    Kistler Thomas

    2011-06-01

    Full Text Available Abstract Background Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients presenting as anti-GBM antibody positive pulmonary-renal syndrome or rapidly progressive glomerulonephritis are also tested positive for anti-neutrophil cytoplasmic antibodies (ANCA. Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable. Case Presentation We report a patient with such dual positivity, who presented with pulmonary hemorrhage, crescentic glomerulonephritis and membranous nephropathy. Plasmapheresis in combination with immunosuppresive therapy led to a rapid remission but the disease relapsed after two years. The serum of the patient was tested positive for antibodies to human lysosomal membrane protein 2 (hLAMP2, a novel autoantigen in patients with active small-vessel vasculitis (SVV. The anti-hLAMP2 antibody levels correlated positively with clinical disease activity in this patient. Conclusion We hypothesize that this antibody may indicate a clinical course similar to ANCA-associated vasculitis in double-positive patients. However, this needs to be confirmed on comprehensive patient cohorts.

  6. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.

    Directory of Open Access Journals (Sweden)

    Hikmat Assi

    Full Text Available Cellular microenvironments, particularly those found in tumors, elicit a tolerogenic DC phenotype which can attenuate immune responses. Central to this process is the STAT3-mediated signaling cascade. As a transcription factor and oncogene, STAT3 promotes the expression of genes which allow tumor cells to proliferate, migrate and evade apoptosis. More importantly, activation of STAT3 in tumor infiltrating immune cells has been shown to be responsible, in part, for their immune-suppressed phenotype. The ability of STAT3 to orchestrate a diverse set of immunosuppressive instructions has made it an attractive target for cancer vaccines. Using a conditional hematopoietic knockout mouse model of STAT3, we evaluated the impact of STAT3 gene ablation on the differentiation of dendritic cells from bone marrow precursors. We also assessed the impact of STAT3 deletion on phagocytosis, maturation, cytokine secretion and antigen presentation by GM-CSF derived DCs in vitro. In addition to in vitro studies, we compared the therapeutic efficacy of DC vaccination using STAT3 deficient DCs to wild type counterparts in an intracranial mouse model of GBM. Our results indicated the following pleiotropic functions of STAT3: hematopoietic cells which lacked STAT3 were unresponsive to Flt3L and failed to differentiate as DCs. In contrast, STAT3 was not required for GM-CSF induced DC differentiation as both wild type and STAT3 null bone marrow cells gave rise to similar number of DCs. STAT3 also appeared to regulate the response of GM-CSF derived DCs to CpG. STAT3 null DCs expressed high levels of MHC-II, secreted more IL-12p70, IL-10, and TNFα were better antigen presenters in vitro. Although STAT3 deficient DCs displayed an enhanced activated phenotype in culture, they elicited comparable therapeutic efficacy in vivo compared to their wild type counterparts when utilized in vaccination paradigms in mice bearing intracranial glioma tumors.

  7. Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — Fermi is a powerful space observatory that will open a wide window on the universe. Gamma rays are the highest-energy form of light, and the gamma-ray sky is...

  8. Cybernetics of Brief Family Therapy.

    Science.gov (United States)

    Keeney, Bradford P.; Ross, Jeffrey M.

    1983-01-01

    Presents a cybernetic view of brief family therapy. Includes a historical discussion of the key ideas underlying brief family therapy, a cybernetic model of therapeutic change, and a clinical case for exemplification. (Author/JAC)

  9. Brief therapy: focused solution development.

    Science.gov (United States)

    De Shazer, S; Berg, I K; Lipchik, E; Nunnally, E; Molnar, A; Gingerich, W; Weiner-Davis, M

    1986-06-01

    This article describes the form of brief therapy developed at the Brief Family Therapy Center. We have chosen a title similar to Weakland, Fisch, Watzlawick, and Bodin's classic paper, "Brief Therapy: Focused Problem Resolution" (20) to emphasize our view that there is a conceptual relationship and a developmental connection between the points of view expressed in the two papers.

  10. Influence of intravitreal avastin on the expression of cell factors in retinal proliferative membrane in proliferative diabetic retinopathy eye%Avastin玻璃体腔注射后糖尿病视网膜病变增生膜中细胞因子的变化

    Institute of Scientific and Technical Information of China (English)

    胡博杰; 曾勍; 刘新玲; 李筱荣; 宋文静

    2013-01-01

    Background A main cause of visual impairment in proliferative diabetic retinopathy (PDR) is vitreous hemorrhage and retinal detachment due to contraction of fibrovascular membrane.To explore the pathogenic mechanism of fibrovascular membrane is a new target for the prevention and management of PDR.Objective This study was to determine the change in expression of vascular endothelial growth factor (VEGF),connective tissue growth factor(CTGF) and pigment epithelium derived factor(PEDF) in the proliferative membranes of patients with PDR after intravitreal injection of avastin,an anti-VEGF agent.Methods This study was approved by the Medical Ethic Committee of Tianjin Medical College,and written informed consent was obtained from each patient before enrollment.A prospective randomized-controlled study was designed.Twenty-six eyes of 24 patients with PDR scheduled for surgery were enrolled from January to June,2008 in Tianjin Medical College Eye Hospital.The patients were randomized into the simple vitrectomy group and avastin injection combined with vitrectomy group,with matched gender,age and disease duration.1.25 mg (0.05 ml) of avastin was intravitreally injected prior to surgery,and vitrectomy was performed 10 days after injection in the avastin injection combined with vitrectomy group,and only vitrectomy was given in the simple vitrectomy group.Preretinal membrane was collected during the surgery.Expression of VEGF,CTGF and PEDF in the preretinal membranes was assayed by immunochemistry.Results VEGF,CTGF and PEDF were expressed in the cytoplasm.The rate of VEGF expression in the preretinal membranes was 30.77% in the avastin injection combined with vitrectomy group,showing a significant reduction in comparison with the simple vitrectomy group(100.00%)(U =4.000,P<0.01).The rate of expression CTGF was remarkable elevated in the avastin injection combined with vitrectomy group compared with the simple vitrectomy group (92.31% vs.62.54%)(U=7.500,P=0

  11. Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells1

    Science.gov (United States)

    Rao, Ravi D; Mladek, Ann C; Lamont, Jeffrey D; Goble, Jennie M; Erlichman, Charles; James, C David; Sarkaria, Jann N

    2005-01-01

    Abstract Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target these protein kinases have been evaluated in multiple clinical trials for cancer patients, including those with GBM. Here we have examined the cellular and molecular effects of a combined kinase inhibition of mTOR (rapamycin) and EGFR (EKI-785) in U87 and U251 GBM cells. Simultaneous treatment with rapamycin and EKI-785 results in synergistic antiproliferative as well as proapoptotic effects. At a molecular level, rapamycin alone significantly decreases S6 phosphorylation, whereas EKI-785 alone promotes substantially reduced signal transducer and activator of transcription (STAT3) phosphorylation. Treatment with rapamycin alone also increases Akt phosphorylation on Ser-473, but this effect is blocked by a simultaneous administration of EKI-785. Individually, EKI-785 diminishes while rapamycin promotes the binding of the translation inhibitor eukaryotic initiation factor 4E binding protein (4EBP1) to the eukaryotic translation initiation factor 4E (eIF4E). In spite of these opposing effects, the highest level of 4EBP1-eIF4E binding occurs with the combination of the two inhibitors. These results indicate that the inhibition of EGFR and mTOR has distinct as well as common signaling consequences and provides a molecular rationale for the synergistic antitumor effects of EKI-785 and rapamycin administration. PMID:16242075

  12. My brief history

    CERN Document Server

    Hawking, Stephen

    2013-01-01

    My Brief History recounts Stephen Hawking’s improbable journey, from his postwar London boyhood to his years of international acclaim and celebrity. Lavishly illustrated with rarely seen photographs, this concise, witty, and candid account introduces readers to a Hawking rarely glimpsed in previous books: the inquisitive schoolboy whose classmates nicknamed him Einstein; the jokester who once placed a bet with a colleague over the existence of a particular black hole; and the young husband and father struggling to gain a foothold in the world of physics and cosmology. Writing with characteristic humility and humor, Hawking opens up about the challenges that confronted him following his diagnosis of ALS at age twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time—one of the iconic books of the twentieth century.

  13. A Brief Report

    OpenAIRE

    Ali, Ather; Vitulano, Lawrence A.

    2010-01-01

    The 2010 Yale Research Symposium on Complementary and Integrative Medicine highlighted original research in related areas by Yale faculty and provided a forum to discuss and debate issues of evidence and plausibility. In this brief report, we describe selected presentations on such diverse foci as nutritional influences on cancer, acupuncture for low back pain, protein intake’s effects on bone consumption, Chinese herb-derived adjuvant chemotherapy, and the relationship between anger and card...

  14. Study of luminosity and spin-up relation in X-ray binary pulsars with long-term monitoring by MAXI/GSC and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Nakajima, Motoki; Yamaoka, Kazutaka

    2015-01-01

    We study the relation between luminosity and spin-period change in X-ray binary pulsars using long-term light curve obtained by the MAXI/GSC all-sky survey and pulse period data from the Fermi/GBM pulsar project. X-ray binaries, consisting of a highly magnetized neutron star and a stellar companion, originate X-ray emission according to the energy of the accretion matter onto the neutron star. The accretion matter also transfers the angular momentum at the Alfven radius, and then spin up the neutron star. Therefore, the X-ray luminosity and the spin-up rate are supposed to be well correlated. We analyzed the luminosity and period-change relation using the data taken by continuous monitoring of MAXI/GSC and Fermi/GBM for Be/X-ray binaries, GX 304$-$1, A 0535$+$26, GRO J1008$-$57, KS 1947$+$300, and 2S 1417$-$624, which occurred large outbursts in the last four years. We discuss the results comparing the obtained observed relation with that of the theoretical model by Ghosh \\& Lamb (1979).

  15. Intravitreal bevacizumab (avastin for circumscribed choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Subrata Mandal

    2011-01-01

    Full Text Available Circumscribed choroidal hemangiomas are rare ophthalmic entities that cause diminution in vision due to accumulation of subretinal and/or intraretinal fluid in the macular area. Various treatment options ranging from conventional laser to photodynamic therapy have been employed to destroy the tumor and reduce the exudation; however, either the inability to penetrate through the exudative fluid or the collateral retinal damage induced by these treatment modalities make them unsuitable for lesions within the macula. We evaluated the role of intravitreal bevacizumab, a pan-vascular endothelial growth factor (VEGF inhibitor, in reducing the sub- and intraretinal fluid in three patients with circumscribed choroidal hemangiomas. All the patients had complete resolution of the serous retinal detachment that was maintained till at least 12 months after the first injection. Intravitreal bevacizumab may be used in combination with thermal laser or photodynamic therapy in treating circumscribed choroidal hemangiomas with subretinal fluid.

  16. A Brief Report

    Science.gov (United States)

    Ali, Ather; Vitulano, Lawrence A.

    2010-01-01

    The 2010 Yale Research Symposium on Complementary and Integrative Medicine highlighted original research in related areas by Yale faculty and provided a forum to discuss and debate issues of evidence and plausibility. In this brief report, we describe selected presentations on such diverse foci as nutritional influences on cancer, acupuncture for low back pain, protein intake’s effects on bone consumption, Chinese herb-derived adjuvant chemotherapy, and the relationship between anger and cardiac arrhythmia. This symposium demonstrated that rigorous research methods are being used to study unconventional therapies and that an integrative medicine approach requires a solid scientific foundation. PMID:20885898

  17. Brief resolved unexplained event

    Science.gov (United States)

    Arane, Karen; Claudius, Ilene; Goldman, Ran D.

    2017-01-01

    Abstract Question For many years, the term apparent life-threatening event (ALTE) was associated with sudden infant death syndrome, and parents who described an acute event in their infants were sent to the hospital for admission. I understand that for infants new terminology is recommended. What is the current approach to a near-death experience of an infant? Answer A recent clinical practice guideline revised the name and definition of an ALTE to a brief resolved unexplained event (BRUE). The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following BRUE symptoms: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination are completed, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness. Low-risk infants should not be admitted to the hospital and overtesting is discouraged. PMID:28115439

  18. 17 CFR 9.23 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 9.23 Section... Appeals § 9.23 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the appeal brief, the exchange must file with the Commission an answering brief. (b) Contents...

  19. 24 CFR 1720.615 - Reply brief.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Reply brief. 1720.615 Section 1720... Proceedings Appeals § 1720.615 Reply brief. A brief in reply to an answering brief, limited to rebuttal of matters in the answering brief, may be filed and served by a party within 7 days after receipt of...

  20. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    Directory of Open Access Journals (Sweden)

    Garcia Juan L

    2010-08-01

    Full Text Available Abstract Background Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Methods Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Results Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders. Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups

  1. Brief encounter networks

    CERN Document Server

    Kostakos, Vassilis; Penn, Alan

    2007-01-01

    Many complex human and natural phenomena can usefully be represented as networks describing the relationships between individuals. While these relationships are typically intermittent, previous research has used network representations that aggregate the relationships at discrete intervals. However, such an aggregation discards important temporal information, thus inhibiting our understanding of the networks dynamic behaviour and evolution. We have recorded patterns of human urban encounter using Bluetooth technology thus retaining the temporal properties of this network. Here we show how this temporal information influences the structural properties of the network. We show that the temporal properties of human urban encounter are scale-free, leading to an overwhelming proportion of brief encounters between individuals. While previous research has shown preferential attachment to result in scale-free connectivity in aggregated network data, we found that scale-free connectivity results from the temporal prope...

  2. SOHO Mission Science Briefing

    Science.gov (United States)

    1995-01-01

    Footage shows the SOHO Mission Pre-Launch Science Briefing. The moderator of the conference is Fred Brown, NASA/GSFC Public Affairs, introduces the panel members. Included are Professor Roger Bonnet, Director ESA Science Program, Dr. Wesley Huntress, Jr., NASA Associate Administrator for Space Science and Dr. Vicente Domingo, ESA SOHO Project Scientist. Also present are several members from the SOHO Team: Dr. Richard Harrison, Art Poland, and Phillip Scherrer. The discussions include understanding the phenomena of the sun, eruption of gas clouds into the atmosphere, the polishing of the mirrors for the SOHO satellite, artificial intelligence in the telescopes, and the launch and operating costs. The panel members are also seen answering questions from various NASA Centers and Paris.

  3. Galileo Mission Science Briefing

    Science.gov (United States)

    1989-07-01

    The first of two tapes of the Galileo Mission Science press briefing is presented. The panel is moderated by George Diller from the Kennedy Space Center (KSC) Public Affairs Office. The participants are John Conway, the director of Payload and operations at Kennedy; Donald E. Williams, Commander of STS-43, the shuttle mission which will launch the Galileo mission; John Casani, the Deputy Assistant Director of Flight Projects at the Jet Propulsion Lab (JPL); Dick Spehalski, Galileo Project Manager at JPL; and Terrence Johnson, Galileo Project Scientist at JPL. The briefing begins with an announcement of the arrival of the Galileo Orbiter at KSC. The required steps prior to the launch are discussed. The mission trajectory and gravity assists from planetary and solar flybys are reviewed. Detailed designs of the orbiter are shown. The distance that Galileo will travel from the sun precludes the use of solar energy for heat. Therefore Radioisotope heater units are used to keep the equipment at operational temperature. A video of the arrival of the spacecraft at KSC and final tests and preparations is shown. Some of the many science goals of the mission are reviewed. Another video showing an overview of the Galileo mission is presented. During the question and answer period, the issue of the use of plutonium on the mission is broached, which engenders a review of the testing methods used to ensure the safety of the capsules containing the hazardous substance. This video has actual shots of the orbiter, as it is undergoing the final preparations and tests for the mission.

  4. Inclusive Briefing and User Involvement

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2011-01-01

    Briefing is not just about specifying needs as requirements but also about evaluating how well design proposals fulfil needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the preproject stage to create a basis for the project decision and can include...... a number of different processes with varying purposes before and during the design and construction activities. Thus, briefing can be regarded as a continuous process but it should also be an inclusive and interactive process with the involvement of all stakeholders, including end users. This article...... includes a literature study on briefing and user involvement in building projects, and presents a case study of a major building project of a new headquarters and media centre for the Danish Broadcasting Corporation in Copenhagen. The building project was actively used as part of a corporate change process...

  5. Neuroophthalmology A brief Vademecum

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Urs E-mail: us@neurol.unizh.ch

    2004-01-01

    The stunning, intricate interaction between the visual, vestibular and optomotor systems--each a miracle on its own--ensures maintenance of orientation in space as well as visual recognition and target selection despite a host of sensory conflicts and adversary disturbances. Their main goals are to keep a target of interest on the fovea by either maintaining or shifting the direction of gaze in order to produce an accurate internal representation of the visual surroundings, in particular the selected target, and to continuously mirror the spatial relationship between these various visual elements and the self. Not surprising, the implementation of this host of elaborate neural networks encompasses almost every part of the brain, including the brainstem, cerebellum, extrapyramidal system and many areas of the cerebral cortex. Thus far, these systems are among the best investigated in brain research; and enormous knowledge was amassed over the last century employing a variety of techniques, including single cell recordings, eye movement studies, functional imaging and neuropsychological observations. In addition, this prolific line of research has enlightened many fundamental principles of neural and neuronal processing, which have subsequently enriched other fields of brain research as well as computational neuroscience, e.g. the discovery of receptive fields, which have now become a ubiquitous concept in many other areas of neurophysiology. This (improperly) brief, fractional and undoubtedly biased Vademecum is meant to accompany the reader into this marvellous field of neurophysiology and neurology. In particular, it stresses the clinical application of its functional neuroanatomy at the bedside, which, in many respects, is superior to other means of investigating a patient.

  6. Neuroophthalmology: a brief Vademecum.

    Science.gov (United States)

    Schwarz, Urs

    2004-01-01

    The stunning, intricate interaction between the visual, vestibular and optomotor systems--each a miracle on its own--ensures maintenance of orientation in space as well as visual recognition and target selection despite a host of sensory conflicts and adversary disturbances. Their main goals are to keep a target of interest on the fovea by either maintaining or shifting the direction of gaze in order to produce an accurate internal representation of the visual surroundings, in particular the selected target, and to continuously mirror the spatial relationship between these various visual elements and the self. Not surprising, the implementation of this host of elaborate neural networks encompasses almost every part of the brain, including the brainstem, cerebellum, extrapyramidal system and many areas of the cerebral cortex. Thus far, these systems are among the best investigated in brain research; and enormous knowledge was amassed over the last century employing a variety of techniques, including single cell recordings, eye movement studies, functional imaging and neuropsychological observations. In addition, this prolific line of research has enlightened many fundamental principles of neural and neuronal processing, which have subsequently enriched other fields of brain research as well as computational neuroscience, e.g. the discovery of receptive fields, which have now become a ubiquitous concept in many other areas of neurophysiology. This (improperly) brief, fractional and undoubtedly biased Vademecum is meant to accompany the reader into this marvellous field of neurophysiology and neurology. In particular, it stresses the clinical application of its functional neuroanatomy at the bedside, which, in many respects, is superior to other means of investigating a patient.

  7. 24 CFR 1720.610 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Answering brief. 1720.610 Section... Proceedings Appeals § 1720.610 Answering brief. Within 20 days after service of an appeal brief upon a party, such party may file an answering brief conforming to the requirements of § 1720.620....

  8. 17 CFR 171.26 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 171.26... Denial and Registration Actions § 171.26 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the apeal brief, the National Futures Association shall file with...

  9. 37 CFR 41.71 - Rebuttal brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Rebuttal brief. 41.71 Section... Rebuttal brief. (a) Within one month of the examiner's answer, any appellant may once file a rebuttal brief. (b)(1) The rebuttal brief of the owner may be directed to the examiner's answer and/or any...

  10. Brief Articles for Latino Parents, 1999 Edition.

    Science.gov (United States)

    ERIC Clearinghouse on Rural Education and Small Schools, Charleston, WV.

    This packet contains six briefs developed specifically for Spanish-speaking Latino parents, and English translations of the briefs. These briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. Earlier editions of brief articles for parents have been used in various ways by…

  11. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Pajonk, F; Kaprealian, T; Kupelian, P; Steinberg, M; Low, D; Sheng, K [Department of Radiation Oncology, UCLA, Los Angeles, CA (United States)

    2015-06-15

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×10{sup 7}, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 10{sup 9} cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work

  12. Usability Briefing for hospital design

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    This PhD thesis is a contribution to an ongoing debate in Denmark about improving the building design processes of complex buildings, especially in relation to the current hospital developments. It provides knowledge about capturing user needs and defines the process model for usability briefing ...... of complex buildings, such as hospitals. The research results have relevance to researchers, architects, facility managers and client organizations planning new complex facilities, and especially for professionals working with briefing and design of hospitals.......This PhD thesis is a contribution to an ongoing debate in Denmark about improving the building design processes of complex buildings, especially in relation to the current hospital developments. It provides knowledge about capturing user needs and defines the process model for usability briefing...... and evaluations, can be fed into briefing and design processes. This PhD thesis proposes methods for usability briefing.Usability is a concept similar to functionality, but usability depends on: subjective view of users, context, culture, situation and experience. Understanding usability is achieved by involving...

  13. Electricity Storage. Technology Brief

    Energy Technology Data Exchange (ETDEWEB)

    Simbolotti, G. [Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Rome (Italy); Kempener, R. [International Renewable Energy Agency IRENA, Bonn (Germany)

    2012-04-15

    Electricity storage is a key technology for electricity systems with a high share of renewables as it allows electricity to be generated when renewable sources (i.e. wind, sunlight) are available and to be consumed on demand. It is expected that the increasing price of fossil fuels and peak-load electricity and the growing share of renewables will result in electricity storage to grow rapidly and become more cost effective. However, electricity storage is technically challenging because electricity can only be stored after conversion into other forms of energy, and this involves expensive equipment and energy losses. At present, the only commercial storage option is pumped hydro power where surplus electricity (e.g. electricity produced overnight by base-load coal or nuclear power) is used to pump water from a lower to an upper reservoir. The stored energy is then used to produce hydropower during daily high-demand periods. Pumped hydro plants are large-scale storage systems with a typical efficiency between 70% and 80%, which means that a quarter of the energy is lost in the process. Other storage technologies with different characteristics (i.e. storage process and capacity, conversion back to electricity and response to power demand, energy losses and costs) are currently in demonstration or pre-commercial stages and discussed in this brief report: Compressed air energy storage (CAES) systems, Flywheels; Electrical batteries; Supercapacitors; Superconducting magnetic storage; and Thermal energy storage. No single electricity storage technology scores high in all dimensions. The technology of choice often depends on the size of the system, the specific service, the electricity sources and the marginal cost of peak electricity. Pumped hydro currently accounts for 95% of the global storage capacity and still offers a considerable expansion potential but does not suit residential or small-size applications. CAES expansion is limited due to the lack of suitable

  14. Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.

    Science.gov (United States)

    Liao, Chia-Leng; Chen, Chien-Min; Chang, Yan-Zin; Liu, Guang-Yaw; Hung, Hui-Chih; Hsieh, Tung-Ying; Lin, Chih-Li

    2014-10-29

    Pine needle extracts of Pinus morrisonicola (Hayata) are commonly used as a functional health beverage. However, it remains unclear what the mechanism is underlying the antitumor activity of pine needle extract. The aims of present study were to investigate the anti-glioblastoma effects of pine needle extracts as well as its bioactive compounds. From three different solvent extracts of pine needles, the water extract displayed the strongest cytotoxicity effects on GBM8901 glioblastoma cells. The isolated compounds were identified as pinocembrin, chrysin, and tiliroside. Chrysin was the most active ingredient of pine needle extract for the induction of apoptosis and suppression of migration and invasion. It also markedly inhibited temozolomide (TMZ)-induced autophagy and O(6)-methylguanine-DNA methyltransferase (MGMT) expression. Because both autophagy and MGMT overexpression have been implicated to TMZ-induced drug resistance in glioblastoma, our results showed that pine needle extract and chrysin may serve as a potential anticancer agent against glioblastoma, especially with regard to sensitizing glioblastoma cells resistant to TMZ.

  15. Beacons In Brief. P/PV In Brief. Issue 2

    Science.gov (United States)

    Blank, Susan; Farley, Chelsea

    2004-01-01

    This second issue in P/PV's "In Brief" series focuses on the San Francisco Beacon Initiative and P/PV's recently released evaluation results. The Beacon Initiative established after-school programs in eight public schools in low-income San Francisco neighborhoods. P/PV's 36-month evaluation examined key developmental and academic outcomes.…

  16. PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression.

    Science.gov (United States)

    Chou, Yu-Cheng; Chang, Meng-Ya; Wang, Mei-Jen; Yu, Fu-Shun; Liu, Hsin-Chung; Harnod, Tomor; Hung, Chih-Huang; Lee, Hsu-Tung; Chung, Jing-Gung

    2015-11-01

    Glioblastoma is the most aggressive primary brain malignancy, and the efficacy of multimodality treatments remains unsatisfactory. Phenethyl isothiocyanate (PEITC), one member of the isothiocyanate family, was found to inhibit the migration and invasion of many types of human cancer cells. In our previous study, PEITC induced the apoptosis of human brain glioblastoma GBM 8401 cells through the extrinsic and intrinsic signaling pathways. In the present study, we first investigated the effects of PEITC on the migration and invasion of GBM 8401 cells. PEITC decreased the migration of GBM 8401 cells in a dose-dependent manner as determined from scratch wound healing and Transwell migration assays. The percentage of inhibition ranged from 46.89 to 15.75%, and from 27.80 to 7.31% after a 48-h treatment of PEITC as determined from the Transwell migration assay and invasion assay, respectively. The western blot analysis indicated that PEITC decreased the levels of proteins associated with migration and invasion, Ras, uPA, RhoA, GRB2, p-p38, p-JNK, p-ERK, p65, SOS1, MMP-2, MMP-9 and MMP-13, in a dose-dependent manner. Real-time PCR analyses revealed that PEITC reduced the mRNA levels of MMP-2, MMP-7, MMP-9 and RhoA in a dose- and time-dependent manner. PEITC exhibited potent anticancer activities through the inhibition of migration and invasion in the GBM 8401 cells. Our findings elucidate the possible molecular mechanisms and signaling pathways of the anti-metastatic effects of PEITC on human brain glioblastoma cells, and PEITC may be considered as a therapeutic agent.

  17. A brief history of error.

    Science.gov (United States)

    Murray, Andrew W

    2011-10-03

    The spindle checkpoint monitors chromosome alignment on the mitotic and meiotic spindle. When the checkpoint detects errors, it arrests progress of the cell cycle while it attempts to correct the mistakes. This perspective will present a brief history summarizing what we know about the checkpoint, and a list of questions we must answer before we understand it.

  18. Childhood Obesity. Special Reference Briefs.

    Science.gov (United States)

    Winick, Myron

    This reference brief deals with the problem of childhood obesity and how it can lead to obesity in the adult. Eighty-four abstracts are presented of studies on the identification, prevention, and treatment of obesity in children, focusing on diet and psychological attitudes. Subjects of the studies were children ranging in age from infancy through…

  19. Humans and Robots. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses human movement and robotic human movement simulators. The activity for students in grades 5-12 provides a history of robotic movement and includes making an End Effector for the robotic arms used on the Space Shuttle and the International Space Station (ISS). (MVL)

  20. 17 CFR 171.25 - Appeal brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 171.25 Section... Denial and Registration Actions § 171.25 Appeal brief. (a) Time to file. Any person who has filed a... appeal brief with the Proceedings Clerk within thirty days after service of the record by the...

  1. 17 CFR 9.22 - Appeal brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 9.22 Section 9... Appeals § 9.22 Appeal brief. (a) Time to file. Any person who has filed a notice of appeal in accordance with the provisions of § 9.20 must perfect the appeal by filing an appeal brief with the...

  2. 37 CFR 41.41 - Reply brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Reply brief. 41.41 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Ex Parte Appeals § 41.41 Reply brief... file a reply brief to an examiner's answer within two months from the date of the examiner's answer....

  3. 37 CFR 41.68 - Respondent's brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Respondent's brief. 41.68... Respondent's brief. (a)(1) Respondent(s) in an appeal may once, within the time limit for filing set forth in... title. (2) The brief must be signed by the party, or the party's duly authorized attorney or agent,...

  4. Impacts of climate change and socio-economic scenarios on flow and water quality of the Ganges, Brahmaputra and Meghna (GBM) river systems: low flow and flood statistics.

    Science.gov (United States)

    Whitehead, P G; Barbour, E; Futter, M N; Sarkar, S; Rodda, H; Caesar, J; Butterfield, D; Jin, L; Sinha, R; Nicholls, R; Salehin, M

    2015-06-01

    The potential impacts of climate change and socio-economic change on flow and water quality in rivers worldwide is a key area of interest. The Ganges-Brahmaputra-Meghna (GBM) is one of the largest river basins in the world serving a population of over 650 million, and is of vital concern to India and Bangladesh as it provides fresh water for people, agriculture, industry, conservation and for the delta system downstream. This paper seeks to assess future changes in flow and water quality utilising a modelling approach as a means of assessment in a very complex system. The INCA-N model has been applied to the Ganges, Brahmaputra and Meghna river systems to simulate flow and water quality along the rivers under a range of future climate conditions. Three model realisations of the Met Office Hadley Centre global and regional climate models were selected from 17 perturbed model runs to evaluate a range of potential futures in climate. In addition, the models have also been evaluated using socio-economic scenarios, comprising (1) a business as usual future, (2) a more sustainable future, and (3) a less sustainable future. Model results for the 2050s and the 2090s indicate a significant increase in monsoon flows under the future climates, with enhanced flood potential. Low flows are predicted to fall with extended drought periods, which could have impacts on water and sediment supply, irrigated agriculture and saline intrusion. In contrast, the socio-economic changes had relatively little impact on flows, except under the low flow regimes where increased irrigation could further reduce water availability. However, should large scale water transfers upstream of Bangladesh be constructed, these have the potential to reduce flows and divert water away from the delta region depending on the volume and timing of the transfers. This could have significant implications for the delta in terms of saline intrusion, water supply, agriculture and maintaining crucial ecosystems such

  5. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Economic trend Asian Development Bank (ADB) said China’s economy is expected to grow 9.6 percent in 2011, even as inflation remains a threat for Asia’s growth engine as well as other economies in the region. China’s GDP growth is forecasted to be moderate this year, compared with a growth of 10.3 percent

  6. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Auto sales slows J.D.Power and Associates,a global marketing information services provider based in the United States,predicts that auto sales growth in the Chinese market which is expected to reach 30 percent in 2010,may slow to 10 percent in 2011, since the government has recognized troubles brought about by the rapid increase of automobiles on the street including traffic congestion,pollution and unrestrained expansion of production capacities.

  7. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Benefits for Africa China’s investments in Africa have brought multiple benefits to the continent, providing better livelihood,more development opportunities and more choices for local people,said Liu Guijin, China’s special envoy on African affairs,at the end of the three-day World Economic Forum on Africa.He said China’s investments cater to Africa’s needs for a

  8. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    RMB trade The Bank of China has opened trading in the yuan currency to U.S.customers. The bank’s New York Branch now lets companies and individuals buy and sell the yuan through accounts with its U.S. branches,although U.S.businesses and individuals can also trade the currency through Western banks.The bank said it offers yuan savings,demand deposit and time deposit accounts to business customers in New York and Los Angeles. A savings account requires a minimum balance of the equivalent of $5,000.

  9. Briefs

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@“The 4th national-& 11th South Central China young scientific researcher symposium on nuclear agricultural sciencee” was held in Zhangjiajie, Hunan on October 22,20O0. 53 representatives from home and abroad attended this symposium sponsored by Hunan Institute of Atomic Energy Application in Agriculture(HIAEAA). At the opening ceremony,HAAS and Zhongshan University, Guangdong, addressed congratuations on the symposium.

  10. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    New plant in Africa Chery Automobile Corp.Ltd.,China’s largest indigenous automaker,will build an assembly plant in Kenya next year, becoming the second Chinese company after truck manufacturer,Beiqi Foton Motors Corp.Ltd.This move is expected to tap the automobile market in East Africa and will further strengthen China’s links with the continent.The company ventured into Kenya through a franchise

  11. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Corn-processing limit According to Chinese Agriculture Minister Han Changfu,China will curb the amount of corn used in producing industrial chemicals to reduce the increasing pressure on grain supplies. The minister said the government aims to contain further processing of corn in non-food and non-livestock industrial usage.

  12. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    3 More competitive According to the Global Competitiveness Report 2011-12,China’s competitiveness ranking rose from 27th to 26th among 142 economies in the world this year, continuing to lead the way among large developing economies.The report said China is one of the world’s least indebted countries,boasts a savings rate of some 53 percent of GDP,and runs only moder ate budget deficits.However,China’s fairly poor results in the financial market development and technological readiness pillars pull down its overall competitiveness performance,said the report.

  13. Briefs

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Baotou Will Be the Largest RE Metals Production Base in ChinaFrom "Baotou Special Electroanalysis Forum of Fluoride-salt System Rare Earth Oxide", which was held by Baotou Rare Earth Leading Group Office, the production of Nd metal in Baotou in 2003 was 2,800 tons, with market shares 28%, and that in 2004 was estimated at 4,000 tons,

  14. Enhancing the crisis management briefing.

    Science.gov (United States)

    Clark, Daniel W; Volkmann, Peter

    2005-01-01

    The Crisis Management Briefing (CMB) is a powerful and versatile crisis intervention tool, effective within a wide variety of populations, settings, and critical incidents. Initially proposed by Everly (2000), the CMB uniquely fills the factual information void following a critical incident. Additionally, a CMB provides essential information on effective coping strategies and available helping resources, tailored to the specific incident(s). The authors expand on the original CMB construct using their combined field experience, offering recommendations on team composition, strategic planning factors, using CISDs vs. CMBs, and specific enhancements for the four phases. They conclude with examples of specific interventions across a variety of events to illustrate their recommendations.

  15. Brief interventions for alcohol problems: a review.

    Science.gov (United States)

    Bien, T H; Miller, W R; Tonigan, J S

    1993-03-01

    Relatively brief interventions have consistently been found to be effective in reducing alcohol consumption or achieving treatment referral of problem drinkers. To date, the literature includes at least a dozen randomized trials of brief referral or retention procedures, and 32 controlled studies of brief interventions targeting drinking behavior, enrolling over 6000 problem drinkers in both health care and treatment settings across 14 nations. These studies indicate that brief interventions are more effective than no counseling, and often as effective as more extensive treatment. The outcome literature is reviewed, and common motivational elements of effective brief interventions are described. There is encouraging evidence that the course of harmful alcohol use can be effectively altered by well-designed intervention strategies which are feasible within relatively brief-contact contexts such as primary health care settings and employee assistance programs. Implications for future research and practice are considered.

  16. Sustainable Markets Investment Briefings: Investment Treaties

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the second of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 2 explains how investment treaties between states work to protect and promote foreign investment.

  17. Luminosity and spin-period evolution of GX 304$-$1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-01-01

    A report is made on the luminosity and pulse-period evolution of the Be binary X-ray pulsar, GX 304$-$1, during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, twelve outbursts repeated by $\\sim$ 132.2 days were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were found to all recur with a well defined period of 132.189$\\pm$0.02 d, which can be identified with the orbital period. The pulse period at $\\sim 275$ s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse-period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital element...

  18. 19 CFR 207.23 - Prehearing brief.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing brief. 207.23 Section 207.23 Customs... EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.23 Prehearing brief... days prior to the date of the hearing specified in the notice of scheduling, a prehearing...

  19. The GO4KIDDS Brief Adaptive Scale

    Science.gov (United States)

    Perry, Adrienne; Taheri, Azin; Ting, Victoria; Weiss, Jonathan

    2015-01-01

    Background: Accurate measurement of adaptive behaviour is important in both clinical and research contexts. While several good clinical measures exist, as well as brief research measures for adults with intellectual disability, there is need for a brief and efficient measure for research with children and youth. We present preliminary psychometric…

  20. Legal briefing: Healthcare ethics committees.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2011-01-01

    This issue's "Legal Briefing" column covers recent legal developments involving institutional healthcare ethics committees. This topic has been the subject of recent articles in JCE. Healthcare ethics committees have also recently been the subject of significant public policy attention. Disturbingly, Bobby Schindler and others have described ethics committees as "death panels." But most of the recent attention has been positive. Over the past several months, legislatures and courts have expanded the use of ethics committees and clarified their roles concerning both end-of-life treatment and other issues. These developments are usefully grouped into the following eight categories: 1. Existence and availability. 2. Membership and composition. 3. Operating procedures. 4. Advisory roles. 5. Decision-making and gate-keeping roles. 6. Confidentiality. 7. Immunity. 8. Litigation and court cases.

  1. Anthropic Rock: a brief history

    Directory of Open Access Journals (Sweden)

    R. B. Cathcart

    2011-03-01

    Full Text Available Stone tool-making is a reductive process. Synthetic rock manufacturing, preeminently an additive process, will not for-ever be confined to only the Earth-biosphere. This brief focuses on humanity's ancient past, hodiernal and possible future even more massive than present-day creation of artificial rocks within our exploitable Solar System. It is mostly Earth-centric account that expands the factual generalities underlying the unique non-copyrighted systemic technogenic rock classification first publicly presented (to the American Geological Society during 2001, by its sole intellectual innovator, James Ross Underwood, Jr. His pioneering, unique exposition of an organization of this ever-increasingly important aspect of the Anthropic Rock story, spatially expansive material lithification, here is given an amplified discussion for the broader geo and space science social group-purpose of encouragement of a completer 21st Century treatment of Underwood's explicative subject-chart (Fig. 2.

  2. A brief history of videogames

    Directory of Open Access Journals (Sweden)

    Simone Belli

    2008-11-01

    Full Text Available The following text contains a brief journey through a short and yet intense adventure, the history of videogames. Since its beginnings in the 1950's decade to the present time, videogames have progressively changed from a hobby for ingeneering studens to the most powerfull leisure industry. In order to gain a better understanding of this phenomenon it is necessary to look over the path of its transformation from a retrospecive point of view. Such a look has necessarily to focus on those devices and games that had made a landmark in the history of videogames, taking them to their current position. Besides, it is crucial to address their implications in contemporary visual culture, along with current prejudices against them. This is a short account about a great history.

  3. Sustainable Markets Investment Briefings: Foreign investment contracts

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fourth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 4 sets out some of the ways in which foreign investment contracts can impact on sustainable development.

  4. Sustainable Markets Investment Briefings: International arbitration

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fifth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 5 explains how international arbitration works to resolve disputes between foreign investors and host states, and outlines some of the problems associated with its use, from a sustainable development perspective.

  5. NASA Tech Briefs, February 2009

    Science.gov (United States)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: Measuring Low Concentrations of Liquid Water in Soil; The Mars Science Laboratory Touchdown Test Facility; Non-Contact Measurement of Density and Thickness Variation in Dielectric Materials; Compact Microwave Fourier Spectrum Analyzer; InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz; Combinatorial Generation of Test Suites; In-Phase Power-Combined Frequency Tripler at 300 GHz; Electronic System for Preventing Airport Runway Incursions; Smaller but Fully Functional Backshell for Cable Connector; Glove-Box or Desktop Virtual-Reality System; Composite Layer Manufacturing with Fewer Interruptions; Improved Photoresist Coating for Making CNT Field Emitters; A Simplified Diagnostic Method for Elastomer Bond Durability; Complex Multifunctional Polymer/Carbon-Nanotube Composites; Very High Output Thermoelectric Devices Based on ITO Nanocomposites; Reducing Unsteady Loads on a Piggyback Miniature Submarine; Ultrasonic/Sonic Anchor; Grooved Fuel Rings for Nuclear Thermal Rocket Engines; Pulsed Operation of an Ion Accelerator; Autonomous Instrument Placement for Mars Exploration Rovers; Mission and Assets Database; TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP); Trajectory Calculator for Finite-Radius Cutter on a Lathe; Integrated System Health Management Development Toolkit.

  6. Cancer Vaccines: A Brief Overview.

    Science.gov (United States)

    Thomas, Sunil; Prendergast, George C

    2016-01-01

    Vaccine approaches for cancer differ from traditional vaccine approaches for infectious disease in tending to focus on clearing active disease rather than preventing disease. In this review, we provide a brief overview of different types of vaccines and adjuvants that have been investigated for the purpose of controlling cancer burdens in patients, some of which are approved for clinical use or in late-stage clinical trials, such as the personalized dendritic cell vaccine sipuleucel-T (Provenge) and the recombinant viral prostate cancer vaccine PSA-TRICOM (Prostvac-VF). Vaccines against human viruses implicated in the development and progression of certain cancers, such as human papillomavirus in cervical cancer, are not considered here. Cancers express "altered self" antigens that tend to induce weaker responses than the "foreign" antigens expressed by infectious agents. Thus, immune stimulants and adjuvant approaches have been explored widely. Vaccine types considered include autologous patient-derived immune cell vaccines, tumor antigen-expressing recombinant virus vaccines, peptide vaccines, DNA vaccines, and heterologous whole-cell vaccines derived from established human tumor cell lines. Opportunities to develop effective cancer vaccines may benefit from seminal recent advances in understanding how immunosuppressive barricades are erected by tumors to mediate immune escape. In particular, targeted ablation of these barricades with novel agents, such as the immune checkpoint drug ipilimumab (anti-CTLA-4) approved recently for clinical use, may offer significant leverage to vaccinologists seeking to control and prevent malignancy.

  7. Engineering Technical Review Planning Briefing

    Science.gov (United States)

    Gardner, Terrie

    2012-01-01

    The general topics covered in the engineering technical planning briefing are 1) overviews of NASA, Marshall Space Flight Center (MSFC), and Engineering, 2) the NASA Systems Engineering(SE) Engine and its implementation , 3) the NASA Project Life Cycle, 4) MSFC Technical Management Branch Services in relation to the SE Engine and the Project Life Cycle , 5) Technical Reviews, 6) NASA Human Factor Design Guidance , and 7) the MSFC Human Factors Team. The engineering technical review portion of the presentation is the primary focus of the overall presentation and will address the definition of a design review, execution guidance, the essential stages of a technical review, and the overall review planning life cycle. Examples of a technical review plan content, review approaches, review schedules, and the review process will be provided and discussed. The human factors portion of the presentation will focus on the NASA guidance for human factors. Human factors definition, categories, design guidance, and human factor specialist roles will be addressed. In addition, the NASA Systems Engineering Engine description, definition, and application will be reviewed as background leading into the NASA Project Life Cycle Overview and technical review planning discussion.

  8. Systemic Therapy: A New Brief Intervention Model.

    Science.gov (United States)

    Searight, H. Russell; Openlander, Patrick

    1984-01-01

    Describes a newly developing mode of problem-oriented brief therapy. The systemic therapy model emphasizes the interactional context of clients' problems and represents an efficient intervention paradigm. (Author/JAC)

  9. 14 CFR 136.7 - Passenger briefings.

    Science.gov (United States)

    2010-01-01

    ... AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS COMMERCIAL AIR TOURS AND NATIONAL PARKS AIR TOUR MANAGEMENT National Air Tour Safety Standards § 136.7 Passenger briefings. (a)...

  10. Brief Review on the Relevance Theory

    Institute of Scientific and Technical Information of China (English)

    龚腾龙; 阿勒腾

    2015-01-01

    Relevance theory has had an impact on the study in various disciplines including linguistics,literature and so on. This paper gives a brief review of the relevance theory and two principles of relevance.

  11. Lacreek NWR pelican disease outbreak briefing

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Briefing for the Region 6 Regional Biologist on a disease outbreak at Lacreek National Wildlife Refuge. Pelican were the most affected species by the outbreak. It is...

  12. Brief Intervention Helps Adolescents Curb Substance Use

    Science.gov (United States)

    ... Helps Adolescents Curb Substance Use Brief Intervention Helps Adolescents Curb Substance Use Email Facebook Twitter Two hour- ... School, in Minneapolis, conducted the trial with 315 adolescent and parent/caregiver pairs. Their findings strengthen evidence, ...

  13. Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells.

    Science.gov (United States)

    Hsu, Y-C; Chen, M-J; Huang, T-Y

    2014-02-27

    Cucurbitacin E (CuE) is a natural compound previously shown to have anti-feedant, antioxidant and antitumor activities as well as a potent chemo-preventive action against cancer. The present study investigates its anti-proliferative property using MTT assay; CuE demonstrated cytotoxic activity against malignant glioma GBM 8401 cells and induced cell cycle G2/M arrest in these cells. CuE-treated cells accumulated in metaphase (CuE 2.5-10 μM) as determined using MPM-2 by flow cytometry. We attempted to characterize the molecular pathways responsible for cytotoxic effects of CuE in GBM 8401 cells. We studied the genome-wide gene expression profile on microarrays and molecular networks by using pathway analysis tools of bioinformatics. The CuE reduced the expression of 558 genes and elevated the levels of 1354 genes, suggesting an existence of the common pathways involved in induction of G2/M arrest. We identified the RB (GADD45β and GADD45γ) and the p53 (GADD45α) signaling pathways as the common pathways, serving as key molecules that regulate cell cycle. Results indicate that CuE produced G2/M arrest as well as the upregulation of GADD45 γ and binding with CDC2. Both effects increased proportionally with the dose of CuE, suggesting that the CuE-induced mitosis delay is regulated by GADD45γ overexpression. Our findings suggest that, in addition to the known effects on cancer prevention, CuE may have antitumor activity in glioma therapy.

  14. NASA Tech Briefs, February 2012

    Science.gov (United States)

    2012-01-01

    This issue contains the following briefs: (1) Optical Comb from a Whispering Gallery Mode Resonator for Spectroscopy and Astronomy Instruments Calibration (2) Real-Time Flight Envelope Monitoring System (3) Nemesis Autonomous Test System (4) Mirror Metrology Using Nano-Probe Supports (5) Automated Lab-on-a-Chip Electrophoresis System (6) Techniques for Down-Sampling a Measured Surface Height Map for Model Validation (7) Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter (8) Frequency to Voltage Converter Analog Front-End Prototype (9) Dust-Tolerant Intelligent Electrical Connection System (10) Gigabit Ethernet Asynchronous Clock Compensation FIFO (11) High-Speed, Multi-Channel Serial ADC LVDS Interface for Xilinx Virtex-5 FPGA (12) Glovebox for GeoLab Subsystem in HDU1-PEM (13) Modified Process Reduces Porosity when Soldering in Reduced Gravity Environments (14) Use of Functionalized Carbon Nanotubes for Covalent Attachment of Nanotubes to Silicon (15) Flexible Plug Repair for Shuttle Wing Leading Edge (16) Three Dimensionally Interlinked, Dense, Solid Form of Single-Walled CNT Ropes (17) Axel Robotic Platform for Crater and Extreme Terrain Exploration (18) Site Tamper and Material Plow Tool - STAMP (19) Magnetic Interface for Segmented Mirror Assembly (20) Transpiration-Cooled Spacecraft-Insulation-Repair Fasteners (21) Fluorescence-Based Sensor for Monitoring Activation of Lunar Dust (22) Aperture Ion Source (23) Virtual Ultrasound Guidance for Inexperienced Operators (24) Model-Based Fault Diagnosis: Performing Root Cause and Impact Analyses in Real Time (25) Interactive Schematic Integration Within the Propellant System Modeling Environment (26) Magnetic and Electric Field Polarizations of Oblique Magnetospheric Chorus Waves (27) Variable Sampling Mapping.

  15. 22 CFR 1423.25 - Filing of brief.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Filing of brief. 1423.25 Section 1423.25 Foreign... PROCEEDINGS § 1423.25 Filing of brief. Any party desiring to submit a brief to the Administrative Law Judge... Judge, but not in excess of thirty (30) days from the close of the hearing. Copies of any brief shall...

  16. 29 CFR 458.86 - Filing of brief.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Filing of brief. 458.86 Section 458.86 Labor Regulations... OF CONDUCT Hearing and Related Matters § 458.86 Filing of brief. Any party desiring to submit a brief... Law Judge may grant a reasonable extension of time. Copies of such brief shall be served on all of...

  17. 37 CFR 2.128 - Briefs at final hearing.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.128 Briefs at final hearing. (a)(1) The brief of the party in the position of plaintiff shall be due not... first brief. A reply brief by the party in the position of plaintiff, if filed, shall be due not...

  18. Intravitreal Bevacizumab (Avastin for Diabetic Retinopathy: The 2010 GLADAOF Lecture

    Directory of Open Access Journals (Sweden)

    J. Fernando Arevalo

    2011-01-01

    Full Text Available This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB on diabetic retinopathy (DR including diabetic macular edema (DME and proliferative diabetic retinopathy (PDR at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of 1.25 or 2.5 mg of bevacizumab for DME, PDR without tractional retinal detachment (TRD, and patients who experienced the development or progression of TRD after an intravitreal injection of 1.25 or 2.5 mg of bevacizumab before vitrectomy for the management of PDR. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA in diffuse DME. Therefore, in the future this new therapy could complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to panretina photocoagulation so that more selective therapy may be applied. Finally, TRD in PDR may occur or progress after IVB used as an adjuvant to vitrectomy. Surgery should be performed 4 days after IVB. Most patients had poorly controlled diabetes mellitus associated with elevated HbA1c, insulin administration, PDR refractory to panretinal photocoagulation, and longer time between IVB and vitrectomy.

  19. Intravitreal Bevacizumab (Avastin) for Diabetic Retinopathy: The 2010 GLADAOF Lecture

    Science.gov (United States)

    Arevalo, J. Fernando; Sanchez, Juan G.; Lasave, Andres F.; Wu, Lihteh; Maia, Mauricio; Bonafonte, Sergio; Brito, Miguel; Alezzandrini, Arturo A.; Restrepo, Natalia; Berrocal, Maria H.; Saravia, Mario; Farah, Michel Eid; Fromow-Guerra, Jans; Morales-Canton, Virgilio

    2011-01-01

    This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB) on diabetic retinopathy (DR) including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of 1.25 or 2.5 mg of bevacizumab for DME, PDR without tractional retinal detachment (TRD), and patients who experienced the development or progression of TRD after an intravitreal injection of 1.25 or 2.5 mg of bevacizumab before vitrectomy for the management of PDR. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA) in diffuse DME. Therefore, in the future this new therapy could complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to panretina photocoagulation so that more selective therapy may be applied. Finally, TRD in PDR may occur or progress after IVB used as an adjuvant to vitrectomy. Surgery should be performed 4 days after IVB. Most patients had poorly controlled diabetes mellitus associated with elevated HbA1c, insulin administration, PDR refractory to panretinal photocoagulation, and longer time between IVB and vitrectomy. PMID:21584260

  20. Kawasaki disease: A brief history.

    Science.gov (United States)

    Burns, J C; Kushner, H I; Bastian, J F; Shike, H; Shimizu, C; Matsubara, T; Turner, C L

    2000-08-01

    Tomisaku Kawasaki published the first English-language report of 50 patients with Kawasaki disease (KD) in 1974. Since that time, KD has become the leading cause of acquired heart disease among children in North America and Japan. Although an infectious agent is suspected, the cause remains unknown. However, significant progress has been made toward understanding the natural history of the disease and therapeutic interventions have been developed that halt the immune-mediated destruction of the arterial wall. We present a brief history of KD, review progress in research on the disease, and suggest avenues for future study. Kawasaki saw his first case of KD in January 1961 and published his first report in Japanese in 1967. Whether cases existed in Japan before that time is currently under study. The most significant controversy in the 1960s in Japan was whether the rash and fever sign/symptom complex described by Kawasaki was connected to subsequent cardiac complications in a number of cases. Pathologist Noboru Tanaka and pediatrician Takajiro Yamamoto disputed the early assertion of Kawasaki that KD was a self-limited illness with no sequelae. This controversy was resolved in 1970 when the first Japanese nationwide survey of KD documented 10 autopsy cases of sudden cardiac death after KD. By the time of the first English-language publication by Kawasaki in 1974, the link between KD and coronary artery vasculitis was well-established. KD was independently recognized as a new and distinct condition in the early 1970s by pediatricians Marian Melish and Raquel Hicks at the University of Hawaii. In 1973, at the same Hawaiian hospital, pathologist Eunice Larson, in consultation with Benjamin Landing at Los Angeles Children's Hospital, retrospectively diagnosed a 1971 autopsy case as KD. The similarity between KD and infantile periarteritis nodosa (IPN) was apparent to these pathologists, as it had been to Tanaka earlier. What remains unknown is the reason for the

  1. Continuous Briefing and User Participation in Building Projects

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2006-01-01

    Briefing is not just about specifying needs as requirements but also about evaluating how well design pro-posals fulfill the needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the pre-project stage to create a basis for the project decision....... It includes an initial strategic brief-ing to define the overall vision and objectives. Parallel to the design briefing it is necessary to carry out a briefing process related to interior design and building operation and before the building is commissioned a briefing process related to moving...... into the building is required. A building project is often part of a change process of the organisation that is going to occupy the building, and this change process should be management carefully to reach a successful result. An important aspect of briefing is to manage the par-ticipation of the coming users...

  2. Case Briefs in Legal English Classes

    Directory of Open Access Journals (Sweden)

    Bilová Stĕpánka

    2016-06-01

    Full Text Available A case brief can be described as a succinct summary of a case which specifies the facts, procedural history, legal issue(s, court decision and legal reasoning supporting the judgment, even though exact formats may vary. Case briefing is a demanding activity which is required from students during their law studies. The goal is to teach students to focus on the essential parts of the case and to obtain a thorough understanding of the case and the reasoning, which means the students need to employ their analytical and critical thinking skills.

  3. Educational Access in India. Country Policy Brief

    Science.gov (United States)

    Online Submission, 2009

    2009-01-01

    This Policy Brief describes and explains patterns of access to schools in India. It outlines policy and legislation on access to education and provides an analysis of access, vulnerability and exclusion. The quantitative data is supported by a review of research which explains the patterns of access and exclusion. It is based on findings from the…

  4. Counseling Services and Student Success. Research Brief

    Science.gov (United States)

    Francis, Perry C.; Horn, Aaron S.

    2016-01-01

    The purpose of this research brief is to provide an overview of mental health issues and counseling services on college campuses. The findings from several national surveys are reviewed to estimate the prevalence of anxiety and depression, suicide and suicidal ideation, and violence among college students. Common prevention and treatment programs…

  5. Quality Physical Education. NASPE Resource Brief

    Science.gov (United States)

    National Association for Sport and Physical Education, 2013

    2013-01-01

    A quality physical education program provides learning opportunities, appropriate instruction, meaningful and challenging content, and student and program assessment. In addition, a quality physical education improves mental alertness, academic performance, and readiness and enthusiasm for learning in the nation's youth. This brief provides a list…

  6. Four Useful Interventions in Brief Family Therapy.

    Science.gov (United States)

    de Shazer, Steve; Molnar, Alex

    1984-01-01

    Describes four interventions in brief family therapy, illustrated by case examples. Interventions are aimed at helping clients solve problems, and three assumptions about the nature of change are described. Results of these interventions suggest there is no clinical distinction between clients' perceived change and observed change. (JAC)

  7. A Brief Introduction to SLA Theories

    Institute of Scientific and Technical Information of China (English)

    佘阿莉

    2015-01-01

    There are a large number of theories,models or hypotheses in the history of SLA research.A brief introduction is made in this paper on several typical ones which have a great influence on foreign language teaching and it is hoped to be useful for the study of SLA research and foreign language teaching.

  8. Economic Education in Malaysia: A Brief Report.

    Science.gov (United States)

    Rao, C. A.

    1978-01-01

    This report provides a brief description of economic education in Malaysia and indicates interest, on the part of various Asian countries, i.e., Malaysia, Singapore, Indonesia, Thailand, and the Philippines, in the establishment of economic education programs. (Editor/RK)

  9. The Wage Gap: Briefing Paper #1.

    Science.gov (United States)

    National Committee on Pay Equity, Washington, DC.

    Women have made slow, steady progress in the labor market since 1979, but the wage gap has not narrowed significantly. This briefing paper updates a September 1987 paper based on "Male-Female Differences in Work Experience, Occupations, and Earnings: 1984" (Current Population Reports, Household Economic Studies, Series P-70, No. 10, issued in…

  10. Genre Identification of Very Brief Musical Excerpts

    Science.gov (United States)

    Mace, Sandra T.; Wagoner, Cynthia L.; Teachout, David J.; Hodges, Donald A.

    2012-01-01

    The purpose of this study was to examine how well individuals were able to identify different music genres from very brief excerpts and whether musical training, gender and preference played a role in genre identification. Listeners were asked to identify genre from classical, jazz, country, metal, and rap/hip hop excerpts that were 125, 250, 500,…

  11. Program/Planning. [Brief No.] 4.

    Science.gov (United States)

    Ingalls, Wilbur R., Jr.

    This report is one of a series of briefs prepared by the American Institute of Architects National Committee on Architecture for Education addressing ways and means of reducing costs in the design and delivery of educational facilities. Specifically, this report is a useful guide to understanding the relationships between educational philosophy…

  12. Early Learning and Educational Technology Policy Brief

    Science.gov (United States)

    Lee, Joan

    2016-01-01

    Recognizing the growth of technology use in early learning settings, the U.S. Department of Education and U.S. Department of Health and Human Services collaborated in the development of the "Early Learning and Educational Technology Policy Brief" to promote developmentally appropriate use of technology in homes and early learning…

  13. 37 CFR 41.37 - Appeal brief.

    Science.gov (United States)

    2010-07-01

    ... and the structure, material, or acts described in the specification as corresponding to each claimed... periods set forth in this section are extendable under the provisions of § 1.136 of this title for patent... time for filing an appeal brief is extendable under the provisions of § 1.136(a) of this title...

  14. Competency-Based Business Degree. Issue Brief

    Science.gov (United States)

    Washington State Board for Community and Technical Colleges, 2014

    2014-01-01

    In January 2015, thirteen Washington community colleges launched an online, competency-based business transfer degree--the first in the state's community and technical college system. This issue brief provides answers to commonly asked questions about the new competency-based degree.

  15. Trouble Brewing in Los Angeles. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    The city of Los Angeles will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Los Angeles faces a total $152.6 billion liability for pensions that are underfunded--including $49.1 billion for the city pension systems, $2.4 billion for…

  16. Trouble Brewing in Orange County. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    Orange County will soon face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Orange County faces a total $41.2 billion liability for retiree benefits that are underfunded--including $9.4 billion for the county pension system and an estimated…

  17. Trouble Brewing in San Francisco. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    The city of San Francisco will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Francisco faces an aggregate $22.4 billion liability for pensions and retiree health benefits that are underfunded--including $14.1 billion for the city…

  18. NASA Ames Fluid Mechanics Laboratory research briefs

    Science.gov (United States)

    Davis, Sanford (Editor)

    1994-01-01

    The Ames Fluid Mechanics Laboratory research program is presented in a series of research briefs. Nineteen projects covering aeronautical fluid mechanics and related areas are discussed and augmented with the publication and presentation output of the Branch for the period 1990-1993.

  19. CTE's Role in Urban Education. Issue Brief

    Science.gov (United States)

    Association for Career and Technical Education (ACTE), 2012

    2012-01-01

    This Issue Brief explores the promising role that career and technical education programs play in addressing key student achievement issues facing urban schools. CTE programs engage urban students by providing rigorous and relevant coursework, fostering positive relationships, establishing clear pathways and connecting education and…

  20. A brief history of dosage compensation

    Indian Academy of Sciences (India)

    Stanley M. Gartler

    2014-08-01

    In 1914, H. J. Muller postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.

  1. ETV Tech Brief: Rapid Fungi and Bacteria Detection Technologies

    Science.gov (United States)

    Technical brief that summarizes the results for Mycometer, Inc. Mycometer®-test and Bactiquant®-test, which are rapid detection technologies for fungi and bacteria. The brief summarizes the results of the verification report and statement.

  2. Citizens Science for Sustainability (SuScit) Project Briefing

    DEFF Research Database (Denmark)

    Eames, Malcolm; Mortensen, Jonas Egmose; Adebowale, Maria;

    This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project.......This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project....

  3. 狼疮肾炎患者anti-GBM与anti-dsDNA和anti-NuA相关性研究%Anti- GBM and Anti- ds DNA Associated with Anti- NuA in Patients with Lupus Nephritis

    Institute of Scientific and Technical Information of China (English)

    李成海; 张聪恪; 赵静; 邹国林

    2006-01-01

    目的 探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系.方法 反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系.结果 28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性.并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致.结论 anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义.

  4. Investigating the factor structure of the Questionnaire on Smoking Urges-Brief (QSU-Brief).

    Science.gov (United States)

    Toll, Benjamin A; Katulak, Nicole A; McKee, Sherry A

    2006-07-01

    This study was designed to investigate the proposed two-factor structure of the 10-item Questionnaire on Smoking Urges-Brief (QSU-Brief) and to provide evidence for the psychometric properties of this questionnaire using the seven-point scoring set from the original QSU study [Tiffany, S.T., Drobes, D.J. (1991). The development and initial validation of a questionnaire on smoking urges. British Journal of Addiction, 86, 1467-1476.]. The study sample (N=576) was comprised of smokers presenting for treatment. Although an initial exploratory factor analysis appeared to replicate the original factor analytic findings of Cox et al. [Cox, L.S., Tiffany, S.T., Christen, A.G. (2001). Evaluation of the brief questionnaire of smoking urges (QSU-Brief) in laboratory and clinical settings. Nicotine and Tobacco Research, 3, 7-16.], when subjected to confirmatory factor analyses, a five-item, two-factor model using the most robust items from the original QSU-Brief factor analysis was the best explanation of the data in the present study. Good internal consistency reliability estimates were also obtained with this model. These results suggest that this shortened form of the QSU-Brief can be used with the original seven-point scoring set as a reliable assessment of the dual nature of smoking urges in a treatment-seeking population.

  5. 39 CFR 3001.115 - Participant statement or brief.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Participant statement or brief. 3001.115 Section... Participant statement or brief. (a) Participant statement. Upon the filing of the petition for review of a... or she may file a brief as described in paragraph (b) of this section presenting the arguments,...

  6. The Impact of Ultrasound on Developing Brain Neurons. Science Briefs

    Science.gov (United States)

    National Scientific Council on the Developing Child, 2007

    2007-01-01

    "Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This brief reports on the study. This Brief summarizes the findings and implications of "Prenatal Exposure to Ultrasound Waves Impacts Neuronal Migration in Mice" (E. S. B. C. Ang, Jr.; V. Gluncic; A. Duque; M. E. Schafer; and P.…

  7. 42 CFR 405.1120 - Filing briefs with the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Filing briefs with the MAC. 405.1120 Section 405....1120 Filing briefs with the MAC. Upon request, the MAC will give the party requesting review, as well... ending with the date the brief is received by the MAC will not be counted toward the...

  8. Adapting the Brief COPE for Chinese Adolescents with Visual Impairments

    Science.gov (United States)

    Yuan, Wei; Zhang, Li-fang; Li, Bing

    2017-01-01

    Introduction: The present research pioneered the effort in assessing adolescents' coping with visual impairment through adapting the Brief COPE in an eastern context. The first study preliminarily explored the applicability of the Brief COPE to Chinese adolescent students with visual impairments. Based on the results, the Brief COPE was modified…

  9. Negotiating Visualities in Briefing and Design

    DEFF Research Database (Denmark)

    Koch, Christian; Bendixen, Mads

    2007-01-01

    Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations are discu......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations...... are discussed. First, drawings are shown to be inscribed with particular interests, making them political instruments. Second, they have prescriptive effects as partially independent actors in the project. Third, they are shown to participate as conscriptions in a complementary process of inscription...

  10. Three brief assessments of math achievement.

    Science.gov (United States)

    Steiner, Eric T; Ashcraft, Mark H

    2012-12-01

    Because of wide disparities in college students' math knowledge-that is, their math achievement-studies of cognitive processing in math tasks also need to assess their individual level of math achievement. For many research settings, however, using existing math achievement tests is either too costly or too time consuming. To solve this dilemma, we present three brief tests of math achievement here, two drawn from the Wide Range Achievement Test and one composed of noncopyrighted items. All three correlated substantially with the full achievement test and with math anxiety, our original focus, and all show acceptable to excellent reliability. When lengthy testing is not feasible, one of these brief tests can be substituted.

  11. Briefing paper for universities on Core Maths

    OpenAIRE

    Glaister, Paul

    2015-01-01

    This briefing paper outlines the rationale for and development of the new Core Maths qualifications, the characteristics of Core Maths, and why Core Maths is important for higher education. It is part of a communication to university vice-chancellors from the Department for Business, Innovation and Skills (BIS) comprising this paper and a joint Ministerial letter from Jo Johnson, Minister of State for Universities and Science in BIS, and Nick Gibb, Minister of State for Schools in the Departm...

  12. Instance Based Methods --- A Brief Overview

    CERN Document Server

    Baumgartner, Peter; 10.1007/s13218-010-0002-x

    2012-01-01

    Instance-based methods are a specific class of methods for automated proof search in first-order logic. This article provides an overview of the major methods in the area and discusses their properties and relations to the more established resolution methods. It also discusses some recent trends on refinements and applications. This overview is rather brief and informal, but we provide a comprehensive literature list to follow-up on the details.

  13. A brief history of new realism

    Directory of Open Access Journals (Sweden)

    Ferraris Maurizio

    2016-01-01

    Full Text Available In this paper I try to sketch a brief history of new realism. Starting from nineteenth century idealism, I then move on to discuss twentieth century postmodernism, which, I argue, is the heir of idealism and the theoretical enemy of new realism. Finally, I offer a reconstruction of how and why contemporary new realism came into being and propose a few remarks on its future perspectives.

  14. Europe BlackHat Briefings 2005

    OpenAIRE

    Boschini, Matteo

    2005-01-01

    Anche quest'anno si è svolta ad Amsterdam la conferenza BlackHat Briefings – Digital Self-Defense. E' una delle più importanti conferenze sulla sicurezza informatica, nella quale vengono presentate le novità tecniche sia per la difesa che per i penetration test od i vulnerability assessment. L'edizione di quest'anno ha dato particolare rilievo agli assessment di web Applications, senza tuttavia trascurare i più bassi livelli protocollari

  15. Trouble Brewing in San Diego. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    The city of San Diego will face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that San Diego faces total of $45.4 billion, including $7.95 billion for the county pension system, $5.4 billion for the city pension system, and an estimated $30.7…

  16. Investigating the factor structure of the Questionnaire on Smoking Urges-Brief (QSU-Brief)

    OpenAIRE

    Toll, Benjamin A.; Katulak, Nicole A.; McKee, Sherry A.

    2005-01-01

    This study was designed to investigate the proposed two-factor structure of the 10-item Questionnaire on Smoking Urges-Brief (QSU-Brief) and to provide evidence for the psychometric properties of this questionnaire using the seven-point scoring set from the original QSU study [Tiffany, S.T., Drobes, D.J. (1991). The development and initial validation of a questionnaire on smoking urges. British Journal of Addiction 86, 1467–1476.]. The study sample (N =576) was comprised of smokers presenting...

  17. A Brief Analysis on William Blake's London

    Institute of Scientific and Technical Information of China (English)

    张莉; 尚彦飞

    2014-01-01

    William Blake (1757-1827) is a renowned British poet in the 18th century. His lyric poems display the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is a well-known lyric poetry, which is thought to be the best vesicle in the West. This paper will analyse this poem in terms of its form, theme, and im-age and then draw a brief conclusion for the characteristics of William Blake's poem.

  18. A brief history of topographical anatomy.

    Science.gov (United States)

    Standring, Susan

    2016-07-01

    This brief history of topographical anatomy begins with Egyptian medical papyri and the works known collectively as the Greco-Arabian canon, the time line then moves on to the excitement of discovery that characterised the Renaissance, the increasing regulatory and legislative frameworks introduced in the 18th and 19th centuries, and ends with a consideration of the impact of technology that epitomises the period from the late 19th century to the present day. This paper is based on a lecture I gave at the Winter Meeting of the Anatomical Society in Cambridge in December 2015, when I was awarded the Anatomical Society Medal.

  19. The Raychaudhuri equations: A brief review

    Indian Academy of Sciences (India)

    Sayan Kar; Soumitra Sengupta

    2007-07-01

    We present a brief review on the Raychaudhuri equations. Beginning with a summary of the essential features of the original article by Raychaudhuri and subsequent work of numerous authors, we move on to a discussion of the equations in the context of alternate non-Riemannian spacetimes as well as other theories of gravity, with a special mention on the equations in spacetimes with torsion (Einstein–Cartan–Sciama–Kibble theory). Finally, we give an overview of some recent applications of these equations in general relativity, quantum field theory, string theory and the theory of relativisitic membranes. We conclude with a summary and provide our own perspectives on directions of future research.

  20. Negotiating Visualizations in Briefing and Design

    DEFF Research Database (Denmark)

    Bendixen, Mads; Koch, Christian

    2007-01-01

    and prescription, changing their roles and configurations, and intersecting and affecting the project process in characteristic ways. Visual representations play a temporary role, and ‘time’ and ‘phase’ set boundaries for them. For practice, the analysis suggests the implication that communitarian management......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations...

  1. A brief analysis on English etymology

    Institute of Scientific and Technical Information of China (English)

    李明珠

    2015-01-01

    In the process of learning English, proficiency in vocabulary is the key point to study a language well. Obviously, it’s very crucial to know about the origin and history of the words. Research on English etymology is conducive to memory, interpretation and understanding of the words. Generally speaking, English etymology is closely connected with British history. Western culture also has exerted profound impact on English etymology, which leads to considerable borrowings pouring into English vocabulary. In brief, this dissertation will inquire into English etymology preliminarily.

  2. CHMP推荐Temodal治疗GBM

    Institute of Scientific and Technical Information of China (English)

    罗娟(摘)

    2005-01-01

    美国药物制造商Schering—Plough公司称欧洲医药局人用药产品委员会(CHMP)已推荐它生产的Ternodal(temozolomide,替莫唑胺)(Ⅰ)作为治疗新诊断的多形恶性胶质细胞瘤(GBM)的一线药物。

  3. Proposed Train and Equip Authorities for Syria: In Brief

    Science.gov (United States)

    2014-12-03

    Proposed Train and Equip Authorities for Syria : In Brief Christopher M. Blanchard Specialist in Middle Eastern Affairs Amy Belasco...COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Proposed Train and Equip Authorities for Syria : In Brief 5a. CONTRACT NUMBER 5b. GRANT...Authorities for Syria : In Brief Congressional Research Service Summary The FY2015 continuing appropriations resolution (H.J.Res. 124, P.L. 113-164

  4. The early history of ideas on brief interventions for alcohol.

    OpenAIRE

    2014-01-01

    AIMS: This study explores the early development of brief interventions for alcohol using a history of ideas approach with a particular focus on intervention content. METHODS: The source publications of the key primary studies published from approximately 1962 to 1992 were examined, followed by a brief review of the earliest reviews in this field. These studies were placed in the context of developments in alcohol research and in public health. RESULTS: After early pioneering work on brief int...

  5. Pre-flight safety briefings, mood and information retention.

    Science.gov (United States)

    Tehrani, Morteza; Molesworth, Brett R C

    2015-11-01

    Mood is a moderating factor that is known to affect performance. For airlines, the delivery of the pre-flight safety briefing prior to a commercial flight is not only an opportunity to inform passengers about the safety features on-board the aircraft they are flying, but an opportunity to positively influence their mood, and hence performance in the unlikely event of an emergency. The present research examined whether indeed the pre-flight safety briefing could be used to positively impact passengers' mood. In addition, the present research examined whether the recall of key safety messages contained within the pre-flight safety briefing was influenced by the style of briefing. Eighty-two participants were recruited for the research and divided into three groups; each group exposed to a different pre-flight cabin safety briefing video (standard, humorous, movie theme). Mood was measured prior and post safety briefing. The results revealed that pre-flight safety briefing videos can be used to manipulate passengers' mood. Safety briefings that are humorous or use movie themes to model their briefing were found to positively affect mood. However, there was a trade-off between entertainment and education, the greater the entertainment value, the poorer the retention of key safety messages. The results of the research are discussed from both an applied and theoretical perspective.

  6. A brief etymology of the collateral circulation.

    Science.gov (United States)

    Faber, James E; Chilian, William M; Deindl, Elisabeth; van Royen, Niels; Simons, Michael

    2014-09-01

    It is well known that the protective capacity of the collateral circulation falls short in many individuals with ischemic disease of the heart, brain, and lower extremities. In the past 15 years, opportunities created by molecular and genetic tools, together with disappointing outcomes in many angiogenic trials, have led to a significant increase in the number of studies that focus on: understanding the basic biology of the collateral circulation; identifying the mechanisms that limit the collateral circulation's capacity in many individuals; devising methods to measure collateral extent, which has been found to vary widely among individuals; and developing treatments to increase collateral blood flow in obstructive disease. Unfortunately, accompanying this increase in reports has been a proliferation of vague terms used to describe the disposition and behavior of this unique circulation, as well as the increasing misuse of well-ensconced ones by new (and old) students of collateral circulation. With this in mind, we provide a brief glossary of readily understandable terms to denote the formation, adaptive growth, and maladaptive rarefaction of collateral circulation. We also propose terminology for several newly discovered processes that occur in the collateral circulation. Finally, we include terms used to describe vessels that are sometimes confused with collaterals, as well as terms describing processes active in the general arterial-venous circulation when ischemic conditions engage the collateral circulation. We hope this brief review will help unify the terminology used in collateral research.

  7. "Talking Pictures Therapy" as Brief Therapy in a School Setting

    Science.gov (United States)

    Loewenthal, Del

    2013-01-01

    This article presents "talking pictures therapy" as an approach to brief therapy, in which photographs are used in brief psychotherapy and counseling with the purpose of enabling clients to express and explore through photographs aspects of their lives they would like to talk about. The author presents case examples using "talking pictures…

  8. "Talking Pictures Therapy" as Brief Therapy in a School Setting

    Science.gov (United States)

    Loewenthal, Del

    2013-01-01

    This article presents "talking pictures therapy" as an approach to brief therapy, in which photographs are used in brief psychotherapy and counseling with the purpose of enabling clients to express and explore through photographs aspects of their lives they would like to talk about. The author presents case examples using "talking…

  9. Drama in design: An open brief to design for wellbeing

    NARCIS (Netherlands)

    Liao, T.; Person, F.E.O.K.

    2012-01-01

    This paper presents a design module in which student teams were challenged in an open brief to design for wellbeing. To design for wellbeing is difficult. Wellbeing is ambiguous, hard to define and highly personal. In the process of defining their own briefs, a drama workshop was set up to help the

  10. 42 CFR 423.2120 - Filing briefs with the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Filing briefs with the MAC. 423.2120 Section 423... (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Reopening, ALJ Hearings, MAC review, and Judicial Review § 423.2120 Filing briefs with the MAC. Upon request, the MAC will give...

  11. Mobile health systems: a brief overview

    Science.gov (United States)

    Voskarides, S.; Pattichis, Constantinos S.; Habib Istepanian, Robert S.; Kyriacou, E.; Pattichis, Marios S.; Schizas, C. N.

    2002-06-01

    Rapid advances in information technology and telecommunications, and more specifically wireless and mobile communications, and their convergence (telematics) are leading to the emergence of a new type of information infrastructure that has the potential of supporting an array of advanced services for healthcare. The objective of this paper is to provide a snapshot of the applications of mobile technology in healthcare. A brief review of the spectrum of these applications and the potential benefits of these efforts will be presented, followed by success case studies in electronic patient record, emergency telemedicine, teleradiology, and home monitoring. It is anticipated that the progress carried out in these efforts, and the potential benefits of emerging mobile technologies will trigger the development of more applications, thus enabling the offering of a better service to the citizen.

  12. The nuclear materials control technology briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Hartwell, J.K.; Fernandez, S.J.

    1992-03-01

    As national and international interests in nuclear arms control and non-proliferation of nuclear weapons, intensify, it becomes ever more important that contributors be aware of the technologies available for the measurement and control of the nuclear materials important to nuclear weapons development. This briefing book presents concise, nontechnical summaries of various special nuclear material (SNM) and tritium production monitoring technologies applicable to the control of nuclear materials and their production. Since the International Atomic Energy Agency (IAEA) operates a multinational, on-site-inspector-based safeguards program in support of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), many (but not all) of the technologies reported in this document are in routine use or under development for IAEA safeguards.

  13. Brief fear preexposure facilitates subsequent fear conditioning.

    Science.gov (United States)

    Iwasaki, Satoshi; Sakaguchi, Tetsuya; Ikegaya, Yuji

    2015-06-01

    Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the sensitivity to a late-coming trauma. Using a mouse PTSD model, we found that a prior foot shock enhances contextual fear conditioning. This shock-induced facilitation of fear conditioning (i.e., priming effect) persisted for 7 days and was prevented by MK801, an N-methyl-D-aspartate receptor antagonist. Other types of trauma, such as forced swimming or tail pinch, did not induce a priming effect on fear conditioning. Thus, a trauma is unlikely generalized to modify the sensitivity to other traumatic experiences. The behavioral procedure employed in this study may be a useful tool to elucidate the etiology of PTSD.

  14. Bats and Viruses: a Brief Review

    Institute of Scientific and Technical Information of China (English)

    Lin-Fa Wang

    2009-01-01

    Bats, probably the most abundant, diverse and geographically dispersed vertebrates on earth, have recently been shown to be the reservoir hosts of a number of emerging viruses responsible for severe human and livestock disease outbreaks. Flying foxes have been demonstrated to be the natural reservoir for Hendra and Nipah viruses. Evidence supporting the possibility of bats as potential reservoirs for SARS coronavirus (SARS-CoV) and Ebola virus has also been reported. The recent discovery of these viruses and other viruses occurring naturally in the bat population provides a unique insight into a diverse pool of potentially emergent and pathogenic viruses. The factors which influence the ability of zoonotic viruses to effectively cross the species barrier from bats to other animal populations are poorly understood. A brief review is provided here on the recently emerged bat viruses and on current and future strategies for research in this area.

  15. Catastrophic Oxidation of Copper: A Brief Review

    Science.gov (United States)

    Belousov, V. V.; Klimashin, A. A.

    2012-10-01

    A brief review of the current understanding of copper accelerated oxidation in the presence of low-melting oxides (Bi2O3, MoO3, and V2O5) is given. Special attention is paid to the kinetics, thermodynamics, and mechanisms of accelerated oxidation of copper. The mechanisms of two stages (fast and superfast) of the copper accelerated oxidation are considered. It is shown that the fast oxidation of copper occurs by a diffusion mechanism. Oxygen diffusion along the liquid channels in the oxide scale is the rate-limiting step in the overall mechanism. The superfast oxidation of copper occurs by a fluxing mechanism. Realization of the particular mechanism depends on the mass ratio of low-melting oxide to the metal. The mass ratios of low-melting oxide to the metal and the oxygen partial pressures for superfast oxidation of copper are established. A model of the fast oxidation of copper is discussed.

  16. The Financial Therapy Association: A Brief History

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2010-10-01

    Full Text Available The purpose of this brief review is to provide a historical context for the conceptualization, development, and launch of the Financial Therapy Association (FTA. The FTA membership base consists of practicing financial planners, financial counselors, psychologists, marriage and family therapists, social workers, financial coaches, psychotherapists, and researchers from these and other disciplines. From the outset, the Association’s purpose has encompassed five goals:To promote a vision of financial therapy, which is the study of cognitive, emotional, behavioral, relational, economic, and integrative aspects of financial health.To provide a forum for researchers, practitioners, the media, and policy makers to share research and practice methods and models of financial therapy.To promote methods of training for those involved in financial therapy.To inform policy and practice management standards as these relate to financial therapy.To stimulate and disseminate clinical, experimental, and survey research on financial therapy.

  17. A brief review on viscosity of nanofluids

    Science.gov (United States)

    Mishra, Purna Chandra; Mukherjee, Sayantan; Nayak, Santosh Kumar; Panda, Arabind

    2014-10-01

    Since the past decade, rapid development in nanotechnology has produced several aspects for the scientists and technologists to look into. Nanofluid is one of the incredible outcomes of such advancement. Nanofluids (colloidal suspensions of metallic and nonmetallic nanoparticles in conventional base fluids) are best known for their remarkable change to enhanced heat transfer abilities. Earlier research work has already acutely focused on thermal conductivity of nanofluids. However, viscosity is another important property that needs the same attention due to its very crucial impact on heat transfer. Therefore, viscosity of nanofluids should be thoroughly investigated before use for practical heat transfer applications. In this contribution, a brief review on theoretical models is presented precisely. Furthermore, the effects of nanoparticles' shape and size, temperature, volume concentration, pH, etc. are organized together and reviewed.

  18. A brief review of molecular information theory

    Science.gov (United States)

    Schneider, Thomas D.

    2011-01-01

    The idea that we could build molecular communications systems can be advanced by investigating how actual molecules from living organisms function. Information theory provides tools for such an investigation. This review describes how we can compute the average information in the DNA binding sites of any genetic control protein and how this can be extended to analyze its individual sites. A formula equivalent to Claude Shannon’s channel capacity can be applied to molecular systems and used to compute the efficiency of protein binding. This efficiency is often 70% and a brief explanation for that is given. The results imply that biological systems have evolved to function at channel capacity, which means that we should be able to build molecular communications that are just as robust as our macroscopic ones. PMID:22110566

  19. Briefing paper -- Remedial Action Assessment System

    Energy Technology Data Exchange (ETDEWEB)

    Buelt, J.L.

    1990-04-01

    Congress has mandated a more comprehensive management of hazardous wastes with the Resource Conservation and Recovery Act (RCRA), the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund'') and the Superfund Amendment and Reauthorization Act (SARA). This mandate includes restoration of disposal sites contaminated through past disposal practices. This mandate applies to facilities operated for and by the Department of Energy (DOE), just as it does to industrial and other institutions. To help implement the CERCLA/SARA remedial investigation and feasibility study (RI/FS) process in a consistent, timely, and cost-effective manner, a methodology needs to be developed that will allow definition, sorting, and screening of remediation technologies for each operable unit (waste site). This need is stated specifically in Section 2.2.2.1 of the October 1989 Applied Research, Development, Demonstration, Testing, and Evaluation (RDDT E) Plan of the DOE. This Briefing Paper is prepared to respond to this need. 1 fig.

  20. Affordances for robots: a brief survey

    Directory of Open Access Journals (Sweden)

    Thomas E. Horton

    2012-12-01

    Full Text Available In this paper, we consider the influence of Gibson's affordance theory on the design of robotic agents. Affordance theory (and the ecological approach to agent design in general has in many cases contributed to the development of successful robotic systems; we provide a brief survey of AI research in this area. However, there remain significant issues that complicate discussions on this topic, particularly in the exchange of ideas between researchers in artificial intelligence and ecological psychology. We identify some of these issues, specifically the lack of a generally accepted definition of "affordance" and fundamental differences in the current approaches taken in AI and ecological psychology. While we consider reconciliation between these fields to be possible and mutually beneficial, it will require some flexibility on the issue of direct perception.

  1. A brief history of mechanical engineering

    CERN Document Server

    Dixit, Uday Shanker; Davim, J Paulo

    2017-01-01

    What is mechanical engineering? What a mechanical engineering does? How did the mechanical engineering change through ages? What is the future of mechanical engineering? This book answers these questions in a lucid manner. It also provides a brief chronological history of landmark events and answers questions such as: When was steam engine invented? Where was first CNC machine developed? When did the era of additive manufacturing start? When did the marriage of mechanical and electronics give birth to discipline of mechatronics? This book informs and create interest on mechanical engineering in the general public and particular in students. It also helps to sensitize the engineering fraternity about the historical aspects of engineering. At the same time, it provides a common sense knowledge of mechanical engineering in a handy manner.

  2. Brief mindfulness induction reduces inattentional blindness.

    Science.gov (United States)

    Schofield, Timothy P; Creswell, J David; Denson, Thomas F

    2015-12-01

    Prior research has linked mindfulness to improvements in attention, and suggested that the effects of mindfulness are particularly pronounced when individuals are cognitively depleted or stressed. Yet, no studies have tested whether mindfulness improves declarative awareness of unexpected stimuli in goal-directed tasks. Participants (N=794) were either depleted (or not) and subsequently underwent a brief mindfulness induction (or not). They then completed an inattentional blindness task during which an unexpected distractor appeared on the computer monitor. This task was used to assess declarative conscious awareness of the unexpected distractor's presence and the extent to which its perceptual properties were encoded. Mindfulness increased awareness of the unexpected distractor (i.e., reduced rates of inattentional blindness). Contrary to predictions, no mindfulness×depletion interaction emerged. Depletion however, increased perceptual encoding of the distractor. These results suggest that mindfulness may foster awareness of unexpected stimuli (i.e., reduce inattentional blindness).

  3. STS-114: Discovery Launch Postponement Press Briefing

    Science.gov (United States)

    2005-01-01

    This press briefing addresses the problem that occurred prior to the launch of the STS-114. Dean Acosta, Deputy Assistant Administrator of Public Affairs, introduces the panel which consists of Dr. Michael Griffin, NASA Administrator, William Readdy, Associate Administrator for Space Operations, Wayne Hale, Space Shuttle Program Deputy Manager, Steve Poulas, Orbiter Project Manager, Mike Leinbach, NASA Launch Director, and Bill Parsons, Space Shuttle Program Manager. Wayne Hale expresses that a problem occurred with one of the low level sensors in the hydrogen tank and that the cause of the problem must be identified and rectified. Steve Poulos talks about establishing a troubleshooting plan as a part of the scrub effort and Mike Leinbach describes the process of draining the external tank. Wayne Hale answers questions about the sensors and if the Space Shuttle Discovery is safe to fly and Steve Poulos answers questions about the possible suspects for this problem.

  4. A brief journey through the immune system.

    Science.gov (United States)

    Yatim, Karim M; Lakkis, Fadi G

    2015-07-07

    This review serves as an introduction to an Immunology Series for the Nephrologist published in CJASN. It provides a brief overview of the immune system, how it works, and why it matters to kidneys. This review describes in broad terms the main divisions of the immune system (innate and adaptive), their cellular and tissue components, and the ways by which they function and are regulated. The story is told through the prism of evolution in order to relay to the reader why the immune system does what it does and why imperfections in the system can lead to renal disease. Detailed descriptions of cell types, molecules, and other immunologic curiosities are avoided as much as possible in an effort to not detract from the importance of the broader concepts that define the immune system and its relationship to the kidney.

  5. A brief history of gravitational wave research

    CERN Document Server

    Chen, Chiang-Mei; Ni, Wei-Tou

    2016-01-01

    For the benefit of the readers of this journal, the editors requested that we prepare a brief review of the history of the development of the theory, the experimental attempts to detect them, and the recent direct observations of gravitational waves (GWs). The theoretical ideas and disputes beginning with Einstein in 1916 regarding the existence and nature of GWs and the extent to which one can rely on the electromagnetic analogy, especially the controversies regarding the quadrupole formula and whether GWs carry energy, are discussed. The theoretical conclusions eventually received strong observational support from the binary pulsar. This provided compelling, although indirect, evidence for GWs carrying away energy--as predicted by the quadrupole formula. On the direct detection experimental side, Weber started more than 50 years ago. In 1966, his bar for GW detection reached a strain sensitivity of a few times 10^-16. His announcement of coincident signals (now considered spurious) stimulated many experimen...

  6. Brief assessment of negative dysmorphic signs

    Directory of Open Access Journals (Sweden)

    Patrizia Fiori

    2010-09-01

    Full Text Available Patrizia Fiori1, Antonio Monaco1, Maria Giannetti Luigi21Central Operative Unit of Neurology, 2Infantile Neuropsychiatry and Social Service, ASL AV, Civil Hospital of Ariano Irpino, University of Naples, ItalyAbstract: Body dysmorphic disorder is a body image dysperception, characterized either by an excessive preoccupation with a presumed or minimal flaw in appearance, or by unrecognition, denial, or even neglect regarding an obvious defect. These features are evaluated by a novel questionnaire, the Brief Assessment of Negative Dysmorphic Signs (BANDS. Moreover, the temperament and character background is examined. The relationship with addictive mentality/behavior and schizoaffectivity is also highlighted. Lastly, the potential shift toward cognitive impairment and dementia is considered.Keywords: body dysmorphic disorder, schizoaffectivity, addiction, behavioral-cognitive impairment

  7. Astrobiology Research in India - A Brief Overview

    Science.gov (United States)

    Peda Nageswara Rao, Pinnamaneni

    2012-07-01

    strobiology is study of the origin, evolution, distribution and future of life on Earth and in the Universe. The discovery of amino acids in carbonaceous chondrite meteorites and complex organic molecules in interstellar clouds, comets and interplanetary dust forced biological interest into space research. The existence of different life forms in extreme environments of Earth, their ability to adapt and survive for long periods in stasis and then recover has given hope that life might exist on other planets. A lot more insight into the origin of life is gained by studying the analogous life on Earth to predict how extraterrestrial life might live. In this paper, a brief account is given on the exogenous and endogenous origin of life on Earth, biochemical basis of life, the need and approach for research in astrobiology, scientific strength of Indian institutions to launch space missions in search of life. A review of the results of the two balloon experiments carried out by Indian Space Research Organization (ISRO) in collaboration with many research institutes in the country as well as the studies carried out elsewhere is also given. An attempt made to address the limitations of the previous experiments, improvements needed, implications of engineering design changes to meet the gaps and institutional resources needed to carry out further studies in astrobiology in the Indian context. A few priority investigations that can be carried out in collaboration with premier national laboratories in India have been identified. A brief account of the international missions that are aimed at finding out habitable Earth-like planets is given. The educational opportunities and interdisciplinary unifying nature of astrobiology research are discussed. The paper concludes with an approach that can be adopted for coordinating the research in this new space science in a programmatic mode.

  8. The brief family relationship scale: a brief measure of the relationship dimension in family functioning.

    Science.gov (United States)

    Fok, Carlotta Ching Ting; Allen, James; Henry, David

    2014-02-01

    The Relationship dimension of the Family Environment Scale, which consists of the Cohesion, Expressiveness, and Conflict subscales, measures a person's perception of the quality of his or her family relationship functioning. This study investigates an adaptation of the Relationship dimension of the Family Environment Scale for Alaska Native youth. The authors tested the adapted measure, the Brief Family Relationship Scale, for psychometric properties and internal structure with 284 12- to 18-year-old predominately Yup'ik Eskimo Alaska Native adolescents from rural, remote communities. This non-Western cultural group is hypothesized to display higher levels of collectivism traditionally organized around an extended kinship family structure. Results demonstrate a subset of the adapted items function satisfactorily, a three-response alternative format provided meaningful information, and the subscale's underlying structure is best described through three distinct first-order factors, organized under one higher order factor. Convergent and discriminant validity of the Brief Family Relationship Scale was assessed through correlational analysis.

  9. Examining the Efficacy of a Brief Mindfulness-Based Stress Reduction (Brief MBSR) Program on Psychological Health

    Science.gov (United States)

    Bergen-Cico, Dessa; Possemato, Kyle; Cheon, Sanghyeon

    2013-01-01

    Objective: The purpose of the study was to examine potential psychological health benefits of participating in a brief (5-week) mindfulness-based stress reduction (brief MBSR) program integrated into an academic course. Participants: Participants were 119 undergraduate students (treatment: "n" = 72; control: "n" = 47) enrolled…

  10. What does "brief" mean? A theoretical critique of the concept of brief therapy from a psychoanalytic viewpoint.

    Science.gov (United States)

    Migone, Paolo

    2014-08-01

    The concept of "brief therapy" contains internal contradictions. The techniques suggested by brief therapists are the same techniques that have been discussed historically in debates on theory of technique, both within and without psychoanalysis (e.g., the experiential factor at the center of the Freud-Ferenczi confrontation is also an important aspect of Gestalt therapy). A time limit is the only operational criterion that allows a rigorous definition of brief therapy; without this criterion it is impossible to discriminate between "brief" and simply "good" therapies (i.e., those in which patients are successfully treated in a short time). An important question is why, with a given patient, a therapist should decide, a priori, to terminate a treatment within a set time. Two clinical examples are presented, illustrating the usefulness of Eissler's concept of parameters as a heuristic framework to identify the potentially defensive nature of both "brief" and "long-term" therapy.

  11. Sustainable Markets Investment Briefings: the regulatory taking doctrine

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the third of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 3 introduces one of the most controversial legal doctrines of investment law – 'regulatory taking' – and sets out its implications for sustainable development.

  12. Brief exposure to copper activates lysosomal exocytosis.

    Science.gov (United States)

    Peña, Karina; Coblenz, Jessica; Kiselyov, Kirill

    2015-04-01

    Copper (Cu) is essential mineral, but its toxicity necessitates existence of powerful machinery responsible for the extraction of excess Cu from the cell. Cu exposure was recently shown to induce the translocation of Cu pump ATP7B to the lysosomes followed by lysosomal exocytosis. Here we sought to investigate the mechanisms underlying the effect of Cu on lysosomal exocytosis. We found that brief exposure to Cu activates lysosomal exocytosis, which was measured as a release of the lysosomal digestive enzyme β-hexosaminidase (β-hex) into the extracellular medium and by the presence lysosomal protein LAMP1 at the plasma membrane. Such release depends on calcium (Ca) and on the lysosomal SNARE VAMP7. ATP7B knockdown using RNAi suppressed the basal lysosomal exocytosis, but did not affect the ability of Cu to activate it. ATP7B knockdown was associated with sustained oxidative stress. The removal of Ca from the extracellular medium suppressed the Cu-dependent component of the lysosomal exocytosis. We propose that Cu promotes lysosomal exocytosis by facilitating a Ca-dependent step of the lysosomal exocytosis.

  13. Legal briefing: organ donation and allocation.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to organ donation and allocation. This topic has been the subject of recent articles in JCE. Organ donation and allocation have also recently been the subjects of significant public policy attention. In the past several months, legislatures and regulatory agencies across the United States and across the world have changed, or considered changing, the methods for procuring and distributing human organs for transplantation. Currently, in the U.S., more than 100,000 persons are waiting for organ transplantation. In China, more than 1.5 million people are waiting. Given the chronic shortage of available organs (especially kidneys and livers) relative to demand, the primary focus of most legal developments has been on increasing the rate of donation. These and related developments are usefully divided into the following 12 topical categories: 1. Revised Uniform Anatomical Gift Act. 2. Presumed Consent and Opt-Out. 3. Mandated Choice. 4. Donation after Cardiac Death. 5. Payment and Compensation. 6. Donation by Prisoners. 7. Donor Registries. 8. Public Education. 9. Other Procurement Initiatives. 10. Lawsuits and Liability. 11. Trafficking and Tourism. 12. Allocation and Distribution.

  14. History of Hanford Site Defense Production (Brief)

    Energy Technology Data Exchange (ETDEWEB)

    GERBER, M S

    2001-02-01

    This paper acquaints the audience with the history of the Hanford Site, America's first full-scale defense plutonium production site. The paper includes the founding and basic operating history of the Hanford Site, including World War II construction and operations, three major postwar expansions (1947-55), the peak years of production (1956-63), production phase downs (1964-the present), a brief production spurt from 1984-86, the end of the Cold War, and the beginning of the waste cleanup mission. The paper also delineates historical waste practices and policies as they changed over the years at the Hanford Site, past efforts to chemically treat, ''fractionate,'' and/or immobilize Hanford's wastes, and resulting major waste legacies that remain today. This paper presents original, primary-source research into the waste history of the Hanford Site. Finally, the paper places the current Hanford Site waste remediation endeavors in the broad context of American and world history.

  15. A brief history of mathematics in finance

    Directory of Open Access Journals (Sweden)

    Erdinç Akyıldırım

    2014-03-01

    Full Text Available In the list of possible scapegoats for the recent financial crises, mathematics, in particular mathematical finance has been ranked, without a doubt, as the first among many and quants, as mathematicians are known in the industry, have been blamed for developing and using esoteric models which are believed to have caused the deepening of the financial crisis. However, as Lo and Mueller (2010 state “Blaming quantitative models for the crisis seems particularly perverse, and akin to blaming arithmetic and the real number system for accounting fraud.” Throughout the history, mathematics and finance have always been in a close relationship. Starting from Babylonians, through Thales, and then Fibonacci, Pascal, Fermat, Bernoulli, Bachelier, Wiener, Kolmogorov, Ito, Markowitz, Black, Scholes, Merton and many others made huge contributions to the development of mathematics while trying to solve finance problems. In this paper, we present a brief historical perspective on how the development of finance theory has influenced and in turn been influenced by the development of mathematical finance theory.

  16. A Brief History of Black Holes

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2006-04-01

    Full Text Available Neither the layman nor the specialist, in general, have any knowledge of the historical circumstances underlying the genesis of the idea of the Black Hole. Essentially, almost all and sundry simply take for granted the unsubstantiated allegations of some ostentatious minority of the relativists. Unfortunately, that minority has been rather careless with the truth and is quite averse to having its claims corrected, notwithstanding the documentary evidence on the historical record. Furthermore, not a few of that vainglorious and disingenuous coterie, particularly amongst those of some notoriety, attempt to dismiss the testimony of the literature with contempt, and even deliberate falsehoods, claiming that history is of no importance. The historical record clearly demonstrates that the Black Hole has been conjured up by combination of confusion, superstition and ineptitude, and is sustained by widespread suppression of facts, both physical and theoretical. The following essay provides a brief but accurate account of events, verifiable by reference to the original papers, by which the scandalous manipulation of both scientific and public opinion is revealed

  17. A Brief History of Black Holes

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2006-04-01

    Full Text Available Neither the layman nor the specialist, in general, have any knowledge of the historical circumstances underlying the genesis of the idea of the Black Hole. Essentially, almost all and sundry simply take for granted the unsubstantiated allegations of some ostentatious minority of the relativists. Unfortunately, that minority has been rather careless with the truth and is quite averse to having its claims corrected, notwithstanding the documentary evidence on the historical record. Furthermore, not a few of that vainglorious and disingenuous coterie, particularly amongst those of some notoriety, attempt to dismiss the testimony of the literature with contempt, and even deliberate falsehoods, claiming that history is of no importance. The historical record clearly demonstrates that the Black Hole has been conjured up by combination of confusion, superstition and ineptitude, and is sustained by widespread suppression of facts, both physical and theoretical. The following essay provides a brief but accurate account of events, verifiable by reference to the original papers, by which the scandalous manipulation of both scientific and public opinion is revealed.

  18. Briefing highlights space weather risks to GPS

    Science.gov (United States)

    Tretkoff, Ernie

    2011-07-01

    Solar storms, which are expected to increase as the Sun nears the most active phase of the solar cycle, can disrupt a variety of technologies on which society relies. Speakers at a 22 June briefing on Capitol Hill in Washington, D. C., focused on how space weather can affect the Global Positioning System (GPS), which is used in a wide range of industries, including commercial air travel, agriculture, national security, and emergency response. Rocky Stone, chief technical pilot for United Airlines, noted that GPS allows more aircraft to be in airspace, saves fuel, and helps aircraft move safely on runways. “Improvements in space weather forecasting need to be pursued,” he said. Precision GPS has also “changed the whole nature of farming,” said Ron Hatch, Director of Navigation Systems, NavCom Technology/John Deere. GPS makes it possible for tractors to be driven in the most efficient paths and for fertilizer and water to be applied precisely to the areas that most need them. Space weather-induced degradation of GPS signals can cause significant loss to farms that rely on GPS. Elizabeth Zimmerman, Deputy Associate Administrator for the Office of Response and Recovery at the Federal Emergency Management Agency (FEMA), described how FEMA relies on GPS for disaster recovery. The agency is developing an operations plan for dealing with space weather, she said.

  19. Surgical safety checklists briefings: Perceived efficacy and team member involvement.

    Science.gov (United States)

    McDowell, D S; McComb, S

    2016-06-01

    Researchers have shown inconsistencies in compliance, outcomes and attitudes of surgical team members related to surgical safety checklist briefings. The purpose of this study was to examine surgical circulator and scrub practitioners' perceptions of safety checklist briefings and team member involvement, and to identify potential improvements in the process based on those perceptions. An anonymous survey was conducted with members of the Association of periOperative Registered Nurses (AORN) and the Association of Surgical Technologists (AST). Questions focused on perceptions of checklist briefing efficacy and team member involvement in safety practices. From the 346 usable responses, a third respondent group of self-identified perioperative leaders emerged. Significant results were obtained related to leaders' perceptions, post-procedure briefings and various perceptions of team member involvement. Study results indicate that variances in safety practices continue as perceived by surgical team members thus presenting opportunities for further examination and improvement of processes in reducing surgical errors.

  20. Brief Guide to Genomics: DNA, Genes and Genomes

    Science.gov (United States)

    ... Breve guía de genómica A Brief Guide to Genomics DNA, Genes and Genomes Deoxyribonucleic acid (DNA) is ... genetic basis for health and disease. Implications of Genomics for Medical Science Virtually every human ailment has ...

  1. Non-destructive foraminiferal paleoclimatic proxies: A brief insight

    Digital Repository Service at National Institute of Oceanography (India)

    Saraswat, R.

    Non-Destructive Foraminiferal Paleoclimatic Proxies: A Brief Insight The knowledge of past climate can help us to understand imminent climatic changes. Oceans are the vast archives of past climate. Various indirect techniques termed as proxies...

  2. Interpretation: bridge of cultures--A brief introduction to interpretation

    Institute of Scientific and Technical Information of China (English)

    袁立梅

    2005-01-01

    This essay gives a brief introduction to interpretation in term of its definition, characteristics, criteria and classification, providing an overall view to this increasingly widely used communication vehicle in today's society.

  3. Mindfulness meditation improves cognition: evidence of brief mental training.

    Science.gov (United States)

    Zeidan, Fadel; Johnson, Susan K; Diamond, Bruce J; David, Zhanna; Goolkasian, Paula

    2010-06-01

    Although research has found that long-term mindfulness meditation practice promotes executive functioning and the ability to sustain attention, the effects of brief mindfulness meditation training have not been fully explored. We examined whether brief meditation training affects cognition and mood when compared to an active control group. After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.

  4. FREE Policy Brief No. 3 - Women's Football and Female Fans

    DEFF Research Database (Denmark)

    Pfister, Gertrud Ursula; Sonntag, Albrecht; Ranc, David

    2015-01-01

    Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football.......Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football....

  5. [Brief psychotherapy in clinical medicine patients].

    Science.gov (United States)

    Knobel, M

    1992-01-01

    The criteria that "illness is biographical crisis od the individual" and that the only medicine is "personal medicine" is stressed. Clinical medicine, which covers medicine in its entirety, demands conceptual and doctrinal reaffirmations so that gradually the patient can come to be dealt with as a human being fron a holistic point of view, which commences with his complaint and consultation, continues with the interview and semiology, to finish with the diagnosis and therapy which, although in some cases it may be surgical, is still medical and integral. All the steps mentioned are bio-socio-cultural thus, whether in the practice of general clinical medicine or in the most specialized and technologically sophisticated clinical medicine, the animist component is not lacking and demands a minimum degree of "psychosomatic" Knowledge. The use of a psychotherapeutic technique is proposed which, while based on the psychoanalysis theory, is distanced technically from it as a "psychotherapy on limited time and goals", which abbreviates the disease, and is projected not as the "focus" of therapeutic work, but as a re-evaluation of the "life style" of each individual, and tends to help to develop a "project for life" suited to the possible personal, familiar and social well-being of the "patient". Technically speaking, this modality of brief psychotherapy is based on the nonuse of transferential interpretations, on impeding the regression od the patient, on facilitating a cognitice-affective development of his conflicts and thus obtain an internal object mutation which allows the transformation of the "past" into true history, and the "present" into vital perspectives. This technique is within reach of every health professional.

  6. A brief examination of optical tagging technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Mark R.; Cahill, Paul A. (Aspecular Optics, Dayton, OH); Drummond, Timothy J.; Wilcoxon, Jess Patrick

    2003-07-01

    Presented within this report are the results of a brief examination of optical tagging technologies funded by the Laboratory Directed Research and Development (LDRD) program at Sandia National Laboratories. The work was performed during the summer months of 2002 with total funding of $65k. The intent of the project was to briefly examine a broad range of approaches to optical tagging concentrating on the wavelength range between ultraviolet (UV) and the short wavelength infrared (SWIR, {lambda} < 2{micro}m). Tagging approaches considered include such things as simple combinations of reflective and absorptive materials closely spaced in wavelength to give a high contrast over a short range of wavelengths, rare-earth oxides in transparent binders to produce a narrow absorption line hyperspectral tag, and fluorescing materials such as phosphors, dies and chemically precipitated particles. One technical approach examined in slightly greater detail was the use of fluorescing nano particles of metals and semiconductor materials. The idea was to embed such nano particles in an oily film or transparent paint binder. When pumped with a SWIR laser such as that produced by laser diodes at {lambda}=1.54{micro}m, the particles would fluoresce at slightly longer wavelengths, thereby giving a unique signal. While it is believed that optical tags are important for military, intelligence and even law enforcement applications, as a business area, tags do not appear to represent a high on return investment. Other government agencies frequently shop for existing or mature tag technologies but rarely are interested enough to pay for development of an untried technical approach. It was hoped that through a relatively small investment of laboratory R&D funds, enough technologies could be identified that a potential customers requirements could be met with a minimum of additional development work. Only time will tell if this proves to be correct.

  7. Legal briefing: conscience clauses and conscientious refusal.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to conscience clauses and conscientious refusal. Not only has this topic been the subject of recent articles in this journal, but it has also been the subject of numerous public and professional discussions. Over the past several months, conscientious refusal disputes have had an unusually high profile not only in courthouses, but also in legislative and regulatory halls across the United States. Healthcare providers' own moral beliefs have been obstructing and are expected to increasingly obstruct patients' access to medical services. For example, some providers, on ethical or moral grounds, have denied: (1) sterilization procedures to pregnant patients, (2) pain medications in end-of-life situations, and (3) information about emergency contraception to rape victims. On the other hand, many healthcare providers have been forced to provide medical treatment that is inconsistent with their moral beliefs. There are two fundamental types of conscientious objection laws. First, there are laws that permit healthcare workers to refuse providing - on ethical, moral, or religious grounds healthcare services that they might otherwise have a legal or employer-mandated obligation to provide. Second, there are laws directed at forcing healthcare workers to provide services to which they might have ethical, moral, or religious objections. Both types of laws are rarely comprehensive, but instead target: (1) certain types of healthcare providers, (2) specific categories of healthcare services, (3) specific patient circumstances, and (4) certain conditions under which a right or obligation is triggered. For the sake of clarity, I have grouped recent legal developments concerning conscientious refusal into eight categories: 1. Abortion: right to refuse 2. Abortion: duty to provide 3. Contraception: right to refuse 4. Contraception: duty to provide 5. Sterilization: right to refuse 6. Fertility, HIV, vaccines

  8. Brief interventions for illicit drug use among peripartum women.

    Science.gov (United States)

    Farr, Sherry L; Hutchings, Yalonda L; Ondersma, Steven J; Creanga, Andreea A

    2014-10-01

    We review the evidence and identify limitations of the current literature on the effectiveness of brief interventions (≤5 intervention sessions) on illicit drug use, treatment enrollment/retention, and pregnancy outcomes among pregnant and postpartum women; and consider this evidence in the context of the broader brief intervention literature. Among 4 published studies identified via systematic review and meeting a priori quality criteria, we found limited, yet promising evidence of the benefit of brief interventions to reduce illicit drug use among postpartum women. Two of the 4 randomized controlled trials tested similar computer-delivered single-session interventions; both demonstrate effects on postpartum drug use. Neither of the 2 randomized controlled trials that assessed treatment use found differences between intervention and control groups. Studies examining brief interventions for smoking and alcohol use among pregnant women, and for illicit drug use in the general adult population, have shown small but statistically significant results of the effectiveness of such interventions. Larger studies, those that examine the effect of assessment alone on illicit drug use, and those that use technology-delivered brief interventions are needed to assess the effectiveness of brief interventions for drug use in the peripartum period.

  9. A brief image-based prevention intervention for adolescents.

    Science.gov (United States)

    Werch, Chudley E Chad; Bian, Hui; Diclemente, Carlo C; Moore, Michelle J; Thombs, Dennis; Ames, Steven C; Huang, I-Chan; Pokorny, Steven

    2010-03-01

    The authors evaluated the efficacy of a brief image-based prevention intervention and assessed current drug use as a moderator of intervention effects. In a clinical trial, 416 high school-age adolescents were randomized to either the brief intervention or usual care control, with data collected at baseline and 3-month follow-up. The brief intervention consisted of a tailored in-person communication and a series of parent/guardian print materials based on the behavior-image model. Health behavior goal setting increased for participants receiving the brief intervention, with an effect size in the small range (d = 0.33). Overall effect sizes for cigarette smoking frequency and quantity and alcohol use frequency and quantity were small (ds = 0.16-0.21) and in favor of the brief intervention. However, adolescents reporting current substance use who received the brief intervention reduced their frequency and heavy use of alcohol, frequency and quantity of cigarette smoking, and reported fewer alcohol/drug problems, with larger effects ranging from small to approaching medium in size (ds = 0.32-0.43, ps goal setting and reduce substance use, particularly among drug-using older adolescents.

  10. Zora’s Politics: A Brief Introduction

    Directory of Open Access Journals (Sweden)

    Ernest Julius Mitchell II

    2013-09-01

    Full Text Available In his introduction to reading Zora Neale Hurston’s politics, Mitchell argues that contemporary scholarship has misread Hurston in significant ways, distorting Hurston’s work and reputation to serve contesting political agendas; thus, in recent years, she has been associated with “a bewildering array of affiliations: republican, libertarian, radical democrat, reactionary conservative, black cultural nationalist, anti-authoritarian feminist, and woman-hating protofascist.” Recuperating Hurston from this impossible political melee of labels, Mitchell argues, requires a careful reading of Hurston’s work dating from her earliest pieces in the late 1920s, as well as surveying her many yet to be published manuscripts and letters; it requires recognition of the transnational and comparative lens through which she reported on political maneuvers and military histories, as well as reading not only her strong criticisms but also her silences, ironic phrasings, and nuanced critiques in her writings on global colonial enterprises. Mitchell’s introduction to the two Hurston essays here reprinted, “I Saw Negro Votes Peddled” (1950 and “Why the Negro Won’t Buy Communism” (1951—courtesy of the American Legion Magazine—is set in the larger frame of his assertion that Hurston’s work should be read with a deep appreciation of her staunch anticolonialism. Tracing her political philosophy through her views of how race and religion are used to valorize an international culture of violence that serves imperialistic and colonial ends, Mitchell takes his reader on a tour of Hurston’s transnational commentary—from the US occupation of Haiti, to the Spanish and British on the Florida peninsula; from Communist Russia and China, to election practices in the US—to set the stage for our encounters with these rarely read Hurston essays. Reading Mitchell’s “Zora’s Politics: A Brief Introduction” provides a firm foundation for a more

  11. Congressional Briefing on Climate Change Impacts and Adaptation

    Science.gov (United States)

    Landau, Elizabeth

    2010-01-01

    During an 8 January 2010 congressional briefing on climate change cosponsored by AGU, speakers discussed the impacts of climate change in the United States and the ability of society to cope with these impacts. More than 200 congressional and federal agency staff attended the briefing, which featured Michael MacCracken, chief scientist for climate change programs at the Climate Institute; Kristie Ebi, executive director of the Intergovernmental Panel on Climate Change Working Group 2 Technical Support Unit; Katharine Jacobs, professor at the University of Arizona's Soil, Water and Environmental Science Department; and Susanne Moser, director and principal researcher at Susanne Moser Research and Consulting. The briefing was jointly sponsored by AGU, the American Association for the Advancement of Science, American Meteorological Society, Ecological Society of America, and Pew Center on Global Climate Change. For more information about AGU's science policy program, visit http://www.agu.org/sci_pol/.

  12. Usability Briefing - a process model for healthcare facilities

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    2014-01-01

    and the purpose is to develop a process model for applying it on complex building projects. Usability briefing is a process in which users are actively involved, not only in evaluations and data gathering, but also in a continuous briefing process with focus on usability. Approach: The model is inductively...... developed from a literature review and three case studies at hospitals in Denmark and Norway. With the aim of connecting to practice, the steps in the model are based on RIBA’s planning phases from 2013. Results/ Originality: The paper presents an integrated usability briefing process model for continuous...... to be applied and further tested. Because of the empirical results, the explanation of the process model focuses mostly phase 1 and 2 of the RIBA planning model....

  13. Renewable energy. From marginal to mainstream. Policy Brief

    Energy Technology Data Exchange (ETDEWEB)

    Veum, K.C.; Uslu, A.; De Coninck, H.C. [ECN Policy Studies, Petten (Netherlands)

    2013-04-15

    This policy brief aims to instigate a debate on the broader enabling conditions required to move renewable energy from marginal shares in the European energy system to a mainstream role. It does so by posing seven key questions related to public movement, the political-industrial complex, resources and sustainability, grids and markets, finance, legal procedures and overall policy. These questions require short- to medium-term attention to keep a long-term renewable energy system within the realm of possibilities. This policy brief also provides ECN's initial reflections on how these key questions could be addressed, and indicates which relevant expertise it can bring to the table.

  14. Brief outbursts in the dwarf nova V1316 Cygni

    CERN Document Server

    Shears, J; Poyner, G; Shears, Jeremy; Boyd, David; Poyner, Gary

    2006-01-01

    Several brief outbursts were detected in the dwarf nova V1316 Cyg during 2005. These events have an average amplitude of 1.4 magnitude and a duration of <1 to 2 days. Whilst no outburst period could be confirmed, the shortest period between detected events is 10 days. These curious brief outbursts appear to be the normal pattern of behaviour for this system. They are of smaller amplitude and shorter duration than normal outbursts previously reported in this star. V1316 Cyg appears to be a very unusual system and we suggest that further observations by both amateur and professional astronomers could yield important information about the underlying mechanism.

  15. Brief detonating characterization of lithanol; Caracterisation detonique succinte du lithanol

    Energy Technology Data Exchange (ETDEWEB)

    Morvan, J.; Courchinoux, R.; Darnez, Ch. [CEA Cesta, Centre d`Etudes Scientifiques et Techniques d`Aquitaine, 33 - Le Barp (France)

    1996-12-31

    Lithanol is a stoichiometric composition of tri-hydrated lithium perchlorate and aluminium. The underwater detonation of this explosive leads to the formation of a gaseous bubble essentially made of water vapor. In this paper, a brief detonating characterization of lithanol is presented using plates projection and cylinder raising up experiments. (J.S.) 5 refs.

  16. A validation study of the Brief Irrational Thoughts Inventory

    NARCIS (Netherlands)

    L.M. Hoogsteder; I.B. Wissink; G.J.J.M. Stams; J.E. van Horn; J. Hendriks

    2014-01-01

    This study examines the reliability and validity of the "Brief Irrational Thoughts Inventory" (BITI) in a sample of 256 justice-involved youths. The BITI is a questionnaire used to determine the nature and severity of irrational thoughts related to aggressive (externalizing), sub-assertive (internal

  17. Initial Educational Experiences of Tertiary Students. LSAY Briefing Number 14

    Science.gov (United States)

    Hillman, Kylie

    2008-01-01

    This "Briefing" presents information about the initial tertiary education experiences, such as satisfaction with aspects of student life and changes to initial enrolments, of two groups of young people, based on two recent Longitudinal Surveys of Australian Youth (LSAY) research reports. One study focused on the first year experiences of a group…

  18. Singularity resolution in loop quantum cosmology: A brief overview

    Energy Technology Data Exchange (ETDEWEB)

    Ashtekar, Abhay, E-mail: ashtekar@gravity.psu.ed [Institute for Gravitation and the Cosmos, Penn State, University Park, PA 16802 (United States)

    2009-10-01

    A brief summary of loop quantum cosmology of homogeneous isotropic models is presented for non-experts with emphasis on the origin of and subtleties associated with the resolution of big bang and big crunch singularities. For further details, and a discussion of some frequently asked questions, the reader is directed to more comprehensive recent reviews.{sup 1}

  19. Leadership: Improving Its Effectiveness. Research Action Brief Number 1.

    Science.gov (United States)

    ERIC Clearinghouse on Educational Management, Eugene, OR.

    This brief summarizes the major findings of significant research studies dealing with different leadership behaviors and strategies for increasing leadership effectiveness. Fred Fiedler's Contingency Theory of Leadership Effectiveness emphasizes that a leader's effectiveness is determined by how well his leadership style fits the specific…

  20. Assessment of a Brief Oral Presentation Assignment in Biopsychology

    Science.gov (United States)

    Sleigh, Merry J.

    2013-01-01

    This study examined the suitability of a brief oral presentation exercise as an assessment method in biopsychology. Undergraduate students researched and presented a five-minute, self-selected fact related to course material, allowing them to practice oral communication skills, such as clearly explaining and carefully listening. Biopsychology…

  1. Issue Brief: Community College and High School Partnerships

    Science.gov (United States)

    Barnett, Elisabeth; Hughes, Katherine

    2010-01-01

    In this Brief, the authors focus on partnerships between community colleges and high schools that may make it more likely for students to complete "three important milestones" on the road to college completion: (1) Enrollment in college; (2) College readiness at enrollment; and (3) Persistence in college. There is a broad range of goals and…

  2. NASA's Bioreactor: Growing Cells in a Microgravity Environment. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing cells in a microgravity environment for grades 9-12. Students are provided with plans for building a classroom bioreactor that can then be used with the included activity on seed growth in a microgravity environment. Additional experimental ideas are also suggested along with a history and background on microgravity…

  3. The Secret to Finland's Success: Educating Teachers. Research Brief

    Science.gov (United States)

    Sahlberg, Pasi

    2010-01-01

    In the last decade, Finland has emerged as the leading OECD country in educational achievement. In examining the sources of Finland's dramatic rise to the top, research shows one key element that has impacted Finland's success above all others: excellent teachers. This policy brief details the key elements of Finland's successful system, examining…

  4. A Brief Illustrated Guide to Understanding Islam. Second Edition.

    Science.gov (United States)

    Ibrahim, I. A.

    This book is a brief guide to understanding Islam, intended to help individuals better understand Islamic culture, Muslims, and the Holy Quran. It consists of the following three chapters: (1) Some Evidence for the Truth of Islam; (2) Some Benefits of Islam; and (3) General Information on Islam. The book is extensively illustrated with photographs…

  5. A NASA Recipe for Protein Crystallography. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing protein crystals. Protein crystals can be very difficult to grow. This activity for grades 9-12 provides a simple recipe for growing protein crystals from Brazil nuts. Included are a history of protein crystals, a discussion of microgravity effects on growth, connections to academic standards, and lab sheets. (MVL)

  6. Motor and Executive Control in Repetitive Timing of Brief Intervals

    Science.gov (United States)

    Holm, Linus; Ullen, Fredrik; Madison, Guy

    2013-01-01

    We investigated the causal role of executive control functions in the production of brief time intervals by means of a concurrent task paradigm. To isolate the influence of executive functions on timing from motor coordination effects, we dissociated executive load from the number of effectors used in the dual task situation. In 3 experiments,…

  7. Eye Tracking: A Brief Guide for Developmental Researchers

    Science.gov (United States)

    Feng, Gary

    2011-01-01

    Eye tracking offers a powerful research tool for developmental scientists. In this brief article, the author introduces the methodology and issues associated with its applications in developmental research, beginning with an overview of eye movements and eye-tracking technologies, followed by examples of how it is used to study the developing mind…

  8. 41 CFR 105-70.036 - Post-hearing briefs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Post-hearing briefs. 105-70.036 Section 105-70.036 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

  9. Readiness for Change. Scaling-Up Brief. Number 3

    Science.gov (United States)

    Fixsen, Dean L.; Blase, Karen A.; Horner, Rob; Sugai, George

    2009-01-01

    The purpose of this "Brief" is to define the variables a state or large district leadership team may wish to consider as they determine if they are "ready" to invest in the scaling-up of an innovation in education. As defined here, "scaling up" means that at least 60% of the students who could benefit from an innovation have access to that…

  10. Longitudinal Construct Validity of Brief Symptom Inventory Subscales in Schizophrenia

    Science.gov (United States)

    Long, Jeffrey D.; Harring, Jeffrey R.; Brekke, John S.; Test, Mary Ann; Greenberg, Jan

    2007-01-01

    Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times…

  11. A Brief Introduction of the History of Linguistics

    Institute of Scientific and Technical Information of China (English)

    王非男

    2015-01-01

    Linguistics is generally defined as the scientific study of language. When it comes to the history of linguistics, it must be related to the origin of human language. This paper will give a brief introduction of the history of linguistics in Ancient Times and in the Middle Ages.

  12. SOLUTION FOCUSED BRIEF COUNSELING (SFBC): ALTERNATIF PENDEKATAN DALAM KONSELING KELUARGA

    OpenAIRE

    Sumarwiyah -; Edris Zamroni; Richma Hidayati

    2015-01-01

    Solution Focused Brief Counseling meruppakan pendekatan konseling yang didasari oleh suatu pandangan bahwa sejatinya kebenaran dan realitas bukanlah suatu yang bersifat absolute namun realitas dan kebenaran itu dapat dikonstruksikan. Dalam konteks konseling keluarga dominasi salah satu anggota dana tau kepala keluarga sering menjadi pemicu masalah sehingga perlu didudukkan pada satu konteks penyelesaian masalah berbasis pada realitas yang ada. Konsleing keluarga dengan pendekatan ini memungki...

  13. Psychometric Properties of the Brief Autism Mealtime Behaviors Inventory

    Science.gov (United States)

    DeMand, Alexandra; Johnson, Cynthia; Foldes, Emily

    2015-01-01

    The purpose of this study was to explore the psychometric properties of the Brief Autism Mealtime Behaviors Inventory (BAMBI). In a sample of 273 well-characterized children with ASD, we explored the factor structure of the BAMBI, determined the internal consistency of a newly derived factor structure and provide an empirically derived cut-off for…

  14. Theoretical development of information science: A brief history

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2016-01-01

    This paper presents a brief history of information science (IS) as viewed by the author. The term ‘information science’ goes back to 1955 and evolved in the aftermath of Claude Shannon’s ‘information theory’ (1948), which also inspired research into problems in fields of library science...... have remained implicit in in the field much of the time....

  15. Validation of the Marijuana Effect Expectancy Questionnaire-Brief

    Science.gov (United States)

    Torrealday, O.; Stein, L. A. R.; Barnett, N.; Golembeske, C.; Lebeau, R.; Colby, S. M.; Monti, P. M.

    2008-01-01

    The purpose of this study was to evaluate a brief version of the Marijuana Effect Expectancy Questionnaire (MEEQ; Schafer & Brown, 1991). The original MEEQ was reduced to 6 items (MEEQ-B). Principal component analysis (PCA) was performed and two factors were identified (positive effects and negative effects) accounting for 52.3% of the variance.…

  16. Toys in Physics Lectures and Demonstrations--A Brief Review

    Science.gov (United States)

    Guemez, J.; Fiolhais, C.; Fiolhais, M.

    2009-01-01

    The use of toys in physics teaching is common. This brief review of the physics of toys intends to show that they are not only very useful in lectures and demonstrations in order to motivate students but also very interesting from a scientific point of view. However, since their physics is sometimes too cumbersome, the effect can be the opposite.…

  17. A Brief Introduction to Foreign Languages Education Policy in China

    Science.gov (United States)

    Zhang, Weiwen

    2012-01-01

    Based on a series of official published documents and relevant research reports, the paper make a brief introduction to foreign languages education policies in China, which included national English teaching guidance, national English language textbooks, national English curriculum standard and the massive English teachers training program, etc.…

  18. Information Brief on Green Power Marketing, 2nd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Sweezey, B.; Houston, A.

    1998-02-01

    This document is the second in a series of information briefs on green power marketing activity in the United States. It includes descriptions of utility green pricing programs, green power marketing activity, retail access legislation and pilot programs, and other data and information supporting the development of green power markets.

  19. Brief psychotherapy in medical practice. Keys to success.

    OpenAIRE

    1993-01-01

    For physicians faced with helping their patients cope with difficult medical problems, solution-oriented psychotherapeutic techniques provide brief, effective interventions. These approaches offer "skeleton keys" that can be used in a broad patient population. They include clarifying the meaning of the medical illness, therapeutic reframing, projection of the problem, role reversal, and face-saving techniques.

  20. Musical "Tune-Ups" for Couples: Brief Treatment Interventions

    Science.gov (United States)

    Duba, Jill D.; Roseman, Christopher

    2012-01-01

    Some couples seek counseling to address warning signs. They may not be facing a relationship crisis but may be more concerned about where they are headed. Hence, a marriage makeover may not necessarily be needed, but instead couples in counseling may benefit from something rejuvenating. In such cases, brief interventions or techniques may be…

  1. 76 FR 44373 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2011-07-25

    ... From the Federal Register Online via the Government Publishing Office MERIT SYSTEMS PROTECTION BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board (MSPB or Board... National Association of Letter Carriers, Case No. G06N-4G-C 10205542 (2011) (Sherman, Arb.); In...

  2. A Brief Method for Conducting a Negative-Reinforcement Assessment.

    Science.gov (United States)

    Zarcone, Jennifer R.; Crosland, Kimberly; Fisher, Wayne W.; Worsdell, April S.; Herman, Kelly

    1999-01-01

    A brief negative-reinforcement assessment was conducted with five children (ages 4 to 14) with developmental disabilities with severe destructive behavior. Children were trained to engage in an escape response and were presented with a variety of stimuli. For each child, several stimuli were identified that may serve as effective negative…

  3. Physiological effects after exposure to heat : A brief literature review

    NARCIS (Netherlands)

    Bogerd, C.P.; Daanen, H.A.M.

    2011-01-01

    Many employees are exposed to heat stress during their work. Although the direct effects of heat are well reported, the long term physiological effects occurring after heat exposure are hardly described. The present manuscript addresses these issues in the form of a brief literature review. Repeated

  4. Brief Family Counseling Intervention: Cibola Cluster, 1997-98.

    Science.gov (United States)

    Mearns, Curt

    This evaluation focuses on the effectiveness of the brief family counseling intervention component of a school-based comprehensive program. Assessment was based upon increased attendance rates; decreased suspension at secondary schools; decreased number of violent incidents; increased number of students receiving mental health services; and…

  5. Organizational Culture and Internationalization: A Brief Literature Review

    Science.gov (United States)

    Nussbaumer, Alison

    2013-01-01

    This brief literature review introduces an area of emerging research about the impact of organizational culture on institutional strategies for internationalization. The review begins by introducing the concept of organizational culture, particularly within higher education. Five articles published between 2003 and 2012 are examined that introduce…

  6. An Update on the "Cycle of Violence." Research in Brief.

    Science.gov (United States)

    Widom, Cathy S.; Maxfield, Michael G.

    This brief updates a longitudinal study comparing the arrest records of abused and neglected children with arrest records of non-abused or neglected children. Subjects included 908 substantiated cases of childhood abuse or neglect processed by the courts from 1967-71 who were matched by sex, age, race, and family socioeconomic status with 667…

  7. Helping Children Make Transitions between Activities. What Works Briefs.

    Science.gov (United States)

    Ostrosky, M. M.; Jung, E. Y.; Hemmeter, M. L.

    This brief discusses the confusion some young children feel in moving from one activity to another (e.g., bus to classroom, cubbies to book reading, art time to lunch) that often results in frustration and challenging behaviors. The paper provides practical information on a variety of strategies to help preschool children make smooth, independent…

  8. RTI Implementation Processes for Middle Schools. Information Brief

    Science.gov (United States)

    Prewett, Sara; Mellard, Daryl; Lieske-Lupo, Jessica

    2011-01-01

    Planning, developing, implementing, and sustaining organizational change, such as Response to Intervention (RTI), is a complex endeavor. This brief is designed to give practitioners guidance based on the implementation activities of middle school practitioners across the country. The authors recognize that secondary schools must consider many…

  9. A Brief Survey Paper on Multi-Legged Robots

    Directory of Open Access Journals (Sweden)

    Mohammad Behmanesh

    2015-03-01

    Full Text Available This paper presents a brief survey on multi-legged robots and their applications in agriculture such as for harvesting. Multi-legged robots have the benefit of more flexibility and adapt to different rough terrain in a better way. They also have very important applications in fulfilling the dangerous tasks such as mine detecting.

  10. Towards the european strategy for particle physics : The briefing book

    NARCIS (Netherlands)

    Akesson, T.; Aleksan, R.; Allanach, B.; Bertolucci, S.; Blondel, A.; Butterworth, J.; Cavalli-Sforza, M.; Cervera, A.; de Naurois, M.; Desch, K.; Egede, U.; Heuer, R.; Hoecker, A.; Huber, P.; Jungmann, K.; Linde, F.; Lombardi, A.; Mangano, M.; Mezzetto, M.; Onderwater, G.; Palanque-Delabrouille, N.; Peach, K.; Polosa, A.; Rondio, E.; Webber, B.; Weiglein, G.; Womersley, J.

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates mat

  11. Training Staff to Implement Brief Stimulus Preference Assessments

    Science.gov (United States)

    Weldy, Christina R.; Rapp, John T.; Capocasa, Kelli

    2014-01-01

    We trained 9 behavioral staff members to conduct 2 brief preference assessments using 30-min video presentations that contained instructions and modeling. After training, we evaluated each staff member's implementation of the assessments in situ. Results indicated that 1 or 2 training sessions for each method were sufficient for teaching each…

  12. The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report

    DEFF Research Database (Denmark)

    Jones, Allan; Clausen, Loa

    2013-01-01

    OBJECTIVE: The aim of the study was to evaluate the efficacy of a brief group cognitive behavior therapy (CBT) program in treating a large cohort of patients diagnosed with bulimia nervosa. METHOD: Treatment outcome defined as reductions in bulimia related behavioral symptoms and bulimia related ...

  13. A brief assessment of physical functioning for prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Jin-Shei Lai

    2010-06-01

    Full Text Available Jin-Shei Lai1, Rita Bode2, Hwee-Lin Wee3, David Eton4, David Cella11Department of Medical Social Sciences, 2Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, IL USA; 3Department of Pharmacy, National University of Singapore, Singapore; 4Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAAbstract: We aimed to validate a more rapid, yet reliable means of assessing physical function (PF for patients with prostate cancer. The sample included 128 prostate cancer patients recruited from urology and general oncology clinics at two Chicago-area hospitals. The main outcome measures were: A 36-item PF item bank that included a 5-item short form (BriefPF and the 10-item PF subscale (PF-10 from the Medical Outcomes Study SF-36. Validity, information function, and relative precision (calculated using Rasch analysis and raw scores of the BriefPF were compared to the PF-10 and the full PF item bank. We found that the BriefPF and PF-10 were strongly correlated (r = 0.85 with the PF bank, and all three scales differentiated patients according to performance status (FPF bank(2,124 = 32.51 P < 0.001, FPF-10(2,121 = 27.35 P < 0.001, FBriefPF (2,123 = 38.40 P < 0.001. BriefPF has excellent precision relative to the PF-10 in measuring patients with different performance status levels. The Rasch-based information function indicated that the BriefPF was more informative than PF-10 in measuring moderate to higher functioning patients. Hence, the BriefPF offers a parsimonious and precise measure of PF for use among men with prostate cancer, and may aid in the timely inclusion of patient-reported outcomes in treatment decision-making.Keywords: quality-of-life, item bank, short-form, Medical Outcomes Study

  14. Prediction of outcome of brief psychotherapy from therapist interpretive interventions.

    Science.gov (United States)

    Marziali, E A

    1984-03-01

    This study replicated Malan's 1976 analysis of psychodynamic interpretations and corrected the major methodological fault in his work: the use of therapist notes for rating the interpretive elements. In this study, the sessions of 25 patients treated in brief dynamic psychotherapy were audiotaped and the ratings of the interpretive interventions were made directly from the audiotapes. Malan's findings were supported. There was a positive association between more favorable outcome, measured on five psychodynamic scales, and the frequency with which therapist interpretations referred to emotions experienced in the transference relationship that were similar to those experienced in relationships with parents and other important persons. The results of this replication indicate that these therapist-offered explanations about the meanings of significant current and past interpersonal relationships contribute to the outcome of brief psychotherapy.

  15. A brief history of the philosophy of time

    CERN Document Server

    Bardon, Adrian

    2013-01-01

    Adrian Bardon's A Brief History of the Philosophy of Time is a short introduction to the history, philosophy, and science of the study of time-from the pre-Socratic philosophers through Einstein and beyond. A Brief History of the Philosophy of Time covers subjects such as time and change, the experience of time, physical and metaphysical approaches to the nature of time, the direction of time, time travel, time and freedom of the will, and scientific and philosophical approaches to eternity and the beginning of time. Bardon employs helpful illustrations and keeps technical language to a minimum in bringing the resources of over 2500 years of philosophy and science to bear on some of humanity's most fundamental and enduring questions.

  16. A Brief Introduction of Communicative Translation Teaching Method

    Institute of Scientific and Technical Information of China (English)

    梁宇; 方艾若

    2013-01-01

      The purpose of this paper is to introduce a new translation teaching method which is based on Skopos theory and commu⁃nicative translation competence training. It makes a brief analysis of the functionalist framework for translation teaching. When more and more universities of China open translation courses for under graduates and postgraduates, it is hoped that this paper could slightly contribute to the translation teaching field.

  17. Stereoselectively fluorinated N-heterocycles: a brief survey

    OpenAIRE

    Hu, Xiang-Guo; Hunter, Luke

    2013-01-01

    The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal chemistry and organocatalysis. This brief review will examine some of the effects that fluorine substitution can have in N-heterocycles, including changes to the molecules’ stability, their conformational behaviour, their hydrogen bonding ability, an...

  18. A brief social history of astrobiology in Ibero-america

    CERN Document Server

    Lemarchand, Guillermo A

    2010-01-01

    The work is divided into three sections: the first one describes the historical evolution of the main arguments presented about the plurality of inhabited worlds, from the presocratics to the birth of modern science. The second section analyzes the race to define the search for life beyond Earth as a scientific activity under a specific name. Finally, the third part presents a brief description of the social history of science that allowed the early development of astrobiology in Iberoamerica.

  19. Psychometric Evaluation of the Brief Acculturation Scale for Hispanics

    OpenAIRE

    Mills, Sarah D; Malcarne, Vanessa L.; Fox, Rina S.; Sadler, Georgia Robins

    2014-01-01

    This study examined the psychometric properties of the Brief Acculturation Scale for Hispanics (BASH), a four-item, language-based measure of acculturation. Participants in the study were 435 Hispanic Americans from a large metropolitan area with English or Spanish language preference. Internal consistency reliability was strong in both language-preference groups. Multiple-group confirmatory factor analysis was used to evaluate the structural validity of the measure. A unidimensional factor s...

  20. Psychometric Properties of the Brief Autism Mealtime Behaviors Inventory

    OpenAIRE

    2015-01-01

    The purpose of this study was to explore the psychometric properties of the Brief Autism Mealtime Behaviors Inventory (BAMBI). In a sample of 273 well-characterized children with ASD, we explored the factor structure of the BAMBI, determined the internal consistency of a newly derived factor structure and provide an empirically derived cut-off for the BAMBI total score. The new psychometrically identified structure consists of 4 factors: 1) Food Selectivity, 2) Disruptive Mealtime Behaviors, ...

  1. Analysis and Verification of Service Interaction Protocols - A Brief Survey

    CERN Document Server

    Salaün, Gwen

    2010-01-01

    Modeling and analysis of interactions among services is a crucial issue in Service-Oriented Computing. Composing Web services is a complicated task which requires techniques and tools to verify that the new system will behave correctly. In this paper, we first overview some formal models proposed in the literature to describe services. Second, we give a brief survey of verification techniques that can be used to analyse services and their interaction. Last, we focus on the realizability and conformance of choreographies.

  2. Brief overview of BioMicroNano Technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Gourley, Paul Lee

    2005-01-01

    This paper provides a brief overview of the fields of biological micro-electromechanical systems (bioMEMs) and associated nanobiotechnologies, collectively denoted as BioMicroNano. Although they are developing at a very rapid pace and still redefining themselves, several stabilized areas of research and development can be identified. Six major areas are delineated, and specific examples are discussed and illustrated. Various applications of the technologies are noted, and potential market sizes are compared.

  3. A Brief Analysis on Empty Categories in Chinese

    Institute of Scientific and Technical Information of China (English)

    XIONG Shao-li

    2014-01-01

    This paper aims to give a brief analysis on the Empty Categories in Chinese. It will first illustrate Chomsky ’s classifica-tion of EC as well as the constraints the subject to briefly, then basing on this classification the author will state some of Chinese scholars’study and research including Xu Liejiong , Huang Zhengde and Hu Jianjun. Finally, the author will compare these clas-sic frameworks and attempt to.

  4. Sulfur Speciation and Extraction in Jet A (Briefing Charts)

    Science.gov (United States)

    2015-08-16

    present in Jet A: • Detrimental to engine performance: coking, clogging, fouling, and deposits possible • SOx emissions are an...Charts 3. DATES COVERED (From - To) July 2015-August 2015 4. TITLE AND SUBTITLE Sulfur Speciation and Extraction in Jet A (Briefing Charts) 5a...T. Reams, Richard C. Lee, Joseph M. Mabry 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER Q0BG 7. PERFORMING ORGANIZATION NAME(S

  5. Backward stochastic Volterra integral equations- a brief survey

    Institute of Scientific and Technical Information of China (English)

    YONG Jiong-min

    2013-01-01

    In this paper, we present a brief survey on the updated theory of backward stochas-tic Volterra integral equations (BSVIEs, for short). BSVIEs are a natural generalization of backward stochastic diff erential equations (BSDEs, for short). Some interesting motivations of studying BSVIEs are recalled. With proper solution concepts, it is possible to establish the corresponding well-posedness for BSVIEs. We also survey various comparison theorems for solutions to BSVIEs.

  6. Guessing personality from a brief sample of behaviour

    OpenAIRE

    Wu, Wenjie

    2015-01-01

    Mentalising as a process for explaining and predicting behavior relates to inferring mental states and traits of others. Previous research of mentalising has focused too heavily on mental states and insufficiently on personality traits. Given this context, the current thesis aimed to explore the phenomenon of forming first impressions of personality based on a brief sample of behavior. In the current research, after being filmed in diverse naturalistic scenarios, targets filled in an “emp...

  7. Illness perception in Polish patients with chronic diseases: Psychometric properties of the Brief Illness Perception Questionnaire.

    Science.gov (United States)

    Nowicka-Sauer, Katarzyna; Banaszkiewicz, Dorota; Staśkiewicz, Izabela; Kopczyński, Piotr; Hajduk, Adam; Czuszyńska, Zenobia; Ejdys, Mariola; Szostakiewicz, Małgorzata; Sablińska, Agnieszka; Kałużna, Anna; Tomaszewska, Magda; Siebert, Janusz

    2016-08-01

    The study evaluates the psychometric properties of a Polish translation of the Brief Illness Perception Questionnaire. A total of 276 patients with chronic conditions (58.7% women) completed the Brief Illness Perception Questionnaire and the Hospital Anxiety and Depression Scale. The internal consistency of the Polish Brief Illness Perception Questionnaire measured with Cronbach's alpha was satisfactory (α = 0.74). Structural validity was demonstrated by significant inter-correlations between the Brief Illness Perception Questionnaire components. Discriminant validity was supported by the fact that the Brief Illness Perception Questionnaire enables patients with various conditions to be differentiated. Significant correlations were found between Brief Illness Perception Questionnaire and depression and anxiety levels. The Polish Brief Illness Perception Questionnaire thus evaluated is a reliable and valid tool.

  8. Test Review: Review of Kaufman Brief Intelligence Test, Second Edition: Kaufman, A. S., & Kaufman, N. L. (2004). "Kaufman Brief Intelligence Test, Second Edition". Bloomington, MN: Pearson, Inc.

    Science.gov (United States)

    Bain, Sherry K.; Jaspers, Kathryn E.

    2010-01-01

    This article presents a review of the Kaufman Brief Intelligence Test, Second Edition (KBIT-2; Kaufman & Kaufman, 2004b), which is designed to provide a brief, individualized format for measuring verbal and nonverbal intelligence in children and adults from the ages of 4 years, 0 months through 90 years, 11 months. The test consists of only three…

  9. iPad-based patient briefing for radiological examinations-a clinical trial.

    Science.gov (United States)

    Schlechtweg, Philipp M; Hammon, Matthias; Giese, David; Heberlein, Christian; Uder, Michael; Schwab, Siegfried A

    2014-08-01

    To analyze if an iPad-based patient briefing can serve as a digital alternative to conventional documentations prior to radiological examinations. One hundred one patients referred for routine MRI were randomized into two groups, who underwent iPad-based and classic written briefing in opposite order. For each briefing completion time, completeness and correctness were noted. Patient's knowledge about the content of either briefing modality was subsequently tested. The influence of patient-related factors on the performance of the electronic briefing (EB) was analyzed. Finally, the patient's subjective impression of the EB was assessed. The mean durations were 4.4 ± 2.2 min for EB and 1.7 ± 1.3 min for the classic briefing (p iPad briefings were returned entirely filled out, whereas 11 % of the classic forms were returned with missing data. No significant differences in memorization of the briefing's information were objectified. There was a positive correlation between the duration of EB and age (r = 0.53; p iPads transfers the information for the patients equally well compared to the classic written approach. Although iPad briefing took patients longer to perform, the majority would prefer it to written consent briefings in the future. Nevertheless, measures have to be undertaken to improve the overall acceptance and performance.

  10. Bevacizumab (Avastin and Thermal Laser Combination Therapy for Peripapillary Choroidal Neovascular Membranes

    Directory of Open Access Journals (Sweden)

    Sean D. Adrean

    2017-01-01

    Full Text Available Objective. This is a retrospective interventional case series describing the results of 5 eyes from 5 patients with symptomatic peripapillary choroidal neovascularization (CNVM receiving initial bevacizumab treatment followed by thermal laser and bevacizumab combination therapy. Methods. Patients received intravitreal bevacizumab injections until the lesions were well-defined. Thermal laser ablation was then administered and followed by an additional bevacizumab injection after one week. Visual outcomes, OCT changes, and rates of recurrence were recorded and analyzed. Results. Median visual outcomes improved from 20/50 to 20/30 (p=0.0232. Median central macular thickness decreased from 347 μm to 152 μm (p=0.0253. The mean visual improvement was 3 lines. An average of 3.8 bevacizumab injections per patient were given overall. Patients were followed for an average of 24 months, during which all eyes were absent for recurrence. Conclusion. Symptomatic peripapillary CNVM may be successfully managed with bevacizumab followed by a combination of thermal laser and bevacizumab without the need for frequent retreatment. The area requiring treatment may be better defined using bevacizumab, limiting the ablation of the healthy retina and improving treatment margins. With this treatment regimen, the patients experience improved visual outcomes and have a low rate of recurrence.

  11. Intravitreal bevacizumab (Avastin in the treatment of macular edema secondary to retinal vein occlusion

    Directory of Open Access Journals (Sweden)

    Juan Carlos Mesa Gutiérrez

    2008-09-01

    Full Text Available Juan Carlos Mesa Gutiérrez, Luis Arias Barquet, Josep Maria Caminal Mitjana, Sergi Prades Almolda, Nùria Planas Domènech, Octavi Pujol Goita, Marc Rubio Caso, Jorge Arruga GinebredaDepartment of Ophthalmology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainObjective: To evaluate efficacy and safety of intravitreal injections of bevacizumab in the treatment of macular edema secondary to retinal vein occlusion (RVO.Methods: Prospective study, noncomparative, interventional case series. Twelve consecutive patients (12 eyes with macular edema associated with nonischemic retinal vein occlusion were treated with intravitreal bevacizumab (1.25 mg. All subjects underwent standardized ophthalmic evaluation at baseline and at weeks 1, 4, 12, and 24, consisting of visual acuity (VA measurement using ETDRS charts, and imaging with ocular coherence tomography evaluating changes in foveal thickness (FT and macular volume (MV.Results: The median age was 66 years (± 4.16, and the median duration of symptoms was 4 months (± 1.81. There were six cases of inferior branch vein occlusion and six cases of superior branch retinal vein occlusion. Mean VA improved from 1.32 ± 0.24 (logMAR values at baseline to 0.8 ± 0.15 (p = 0.0003 at the 6-month follow-up. The macular edema responded promptly, and a trend to restoration of normal macular anatomy was observed at by the seventh day. Mean FT improved from 615.50 ± 116.29 microns to 420 ± 72.53 microns (p = 0.001, and the mean MV improved from 19.81 ± 2.31mm3 to 9.23 ± 1.38 (p = 0.0001 at the 6-month follow-up.Keywords: Bevacizumab, retinal vein occlusion, intravitreal injection, vascular endothelial growth factor

  12. Genetic Modification of Neurons to Express Bevacizumab for Local Anti-angiogenesis Treatment of Glioblastoma

    Science.gov (United States)

    Wang, Lan; Aronowitz, Eric; Dyke, Jonathan P.; Ballon, Douglas J.; Havlicek, David F.; Frenk, Esther Z.; De, Bishnu P.; Chiuchiolo, Maria J.; Sondhi, Dolan; Hackett, Neil R.; Kaminsky, Stephen M.; Tabar, Viviane; Crystal, Ronald G.

    2014-01-01

    The median survival of glioblastoma multiforme (GBM) approximately 1 yr. Following surgical removal, systemic therapies are limited by the blood-brain barrier. To circumvent this, we developed a method to modify neurons with the genetic sequence for therapeutic monoclonal antibodies using adeno-associated virus (AAV) gene transfer vectors, directing persistent, local expression in the tumor milieu. The human U87MG GBM cell line or patient-derived early passage GBM cells were administered to the striatum of NOD/SCID immunodeficient mice. AAVrh.10BevMab, an AAVrh.10-based vector coding for bevacizumab (Avastin®), an anti-human vascular endothelial growth factor (VEGF) monoclonal antibody, was delivered to the area of the GBM xenograft. Localized expression of bevacizumab was demonstrated by quantitative PCR, ELISA and Western. Immunohistochemistry showed the bevacizumab was expressed in neurons. Concurrent administration of AAVrh.10BevMab with the U87MG tumor reduced tumor blood vessel density, and tumor volume and increased survival. Administration of AAVrh.10BevMab 1 wk after U87MG xenograft reduced growth and increased survival. Studies with patient-derived early passage GBM primary cells showed a reduction in primary tumor burden with an increased survival. This data supports the strategy of AAV-mediated CNS gene therapy to treat GBM, overcoming the blood-brain barrier through local, persistent delivery of an anti-angiogenesis monoclonal antibody. PMID:25501993

  13. Brief Homeopathic Pathogenetic Experimentation: A Unique Educational Tool in Brazil

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    Marcus Zulian Teixeira

    2009-01-01

    Full Text Available In homeopathy, many difficulties are encountered in understanding theoretical presuppositions because they represent different paradigms from those of hegemonic science. In our medical school, we developed a brief homeopathic pathogenetic experimentation course to be added as curricular content and a didactic method in homeopathic disciplines to add practical experience to the theoretical approach of homeopathic presuppositions. In accordance with the premises laid out by Hahnemann, the father of homeopathy, brief pathogenetic experimentation was offered on a voluntary basis for students who were free of chronic diseases and who had not regularly used medication in the last 3 months. The clinical test, either crossed or sequential (randomized and blind, was used as a study model. Single weekly doses of a homeopathic medicine of 30 cH or placebo were taken by participants during 4 weeks after which crossover of the experimented substances took place for another 4 weeks. Polycrest medicines were used so that symptoms developed by the participants could be compared to those described in Homeopathic Materia Medica. Thirty-three of the 50 students who studied homeopathy as an elective discipline over the last 4 years at the School of Medicine of the University of São Paulo (FMUSP participated. Participants described symptoms according to specific methodology including many comments with peculiar characteristics and notable idiosyncrasies. All these students endorsed the course because it contributed to their understanding of how dynamized substances produced symptoms in healthy participants as well as the cure of symptoms according to the casual similitude principle. Brief homeopathic pathogenetic experimentation proved to be an effective method to observe the idiosyncratic manifestations of human individuality based on qualitative methodology, thus building a basis of understanding of homeopathy.

  14. ROMANIAN AERONAUTICAL METEOROLOGY APPLICABLE LEGAL FRAMEWORK –BRIEFING

    Directory of Open Access Journals (Sweden)

    CATALIN POPA

    2012-05-01

    Full Text Available The purpose of this briefing is toprovide an overview of the aeronautical meteorology legal framework in Romania. In this context, the role and importance of aeronautical meteorology in international air traffic management will be underlined, with focus on the civil aviation activity in Romania. The international legal framework and modalities of implementing these rules at national level will constitute a significant part of the present study., Specific accent will be put on the national regulatory framework and structure, means of updating it, and how it responds to changing regulatory requirements.

  15. A Brief Introduction to Astronomy in the Middle East

    CERN Document Server

    Steele, John M

    2012-01-01

    The Middle East is the birthplace of astronomy and the centre for its development during the medieval period. In this brief introduction John Steele offers an intriguing insight into Middle Eastern achievements in astronomy and their profound influence on the rest of the world. Amongst other things, the book traces the Late Babylonians' ingenious schemes for modelling planetary motion. It also reveals how medieval Islamic advances in the study of the heavens, and the design of precise astronomical instruments, led to breakthroughs by Renaissance practitioners such as Copernicus and Kepler. An

  16. Digital Library Activities in Europe: A Brief Overview

    Directory of Open Access Journals (Sweden)

    Jia Liu

    2005-06-01

    Full Text Available The article is a brief overview of the digital library activities happening in the last decade in Europe. At first the definitions of the digital library was discussed. Then in the main part of the article the programs and projects on the digital library taking place in Europe are described briefly at three levels, which are digital library activities across Europe, national digital library activities and local digital library activities. In addition to the programs and projects several examples of the conferences and institutions in the field are also given in the article. Finally some conclusions are drawn based on the description above.

  17. Stereoselectively fluorinated N-heterocycles: a brief survey.

    Science.gov (United States)

    Hu, Xiang-Guo; Hunter, Luke

    2013-11-29

    The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules' physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal chemistry and organocatalysis. This brief review will examine some of the effects that fluorine substitution can have in N-heterocycles, including changes to the molecules' stability, their conformational behaviour, their hydrogen bonding ability, and their basicity. Finally, some methods for the synthesis of stereoselectively fluorinated N-heterocycles will also be reviewed.

  18. Stereoselectively fluorinated N-heterocycles: a brief survey

    Directory of Open Access Journals (Sweden)

    Xiang-Guo Hu

    2013-11-01

    Full Text Available The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal chemistry and organocatalysis. This brief review will examine some of the effects that fluorine substitution can have in N-heterocycles, including changes to the molecules’ stability, their conformational behaviour, their hydrogen bonding ability, and their basicity. Finally, some methods for the synthesis of stereoselectively fluorinated N-heterocycles will also be reviewed.

  19. Operations research at CSIR: A brief history through cases

    Directory of Open Access Journals (Sweden)

    HW Ittmann

    2007-06-01

    Full Text Available Apart from work in the mining industry during the 1950s, the first real Operations Research (OR group in South Africa was established at CSIR in the early 1960s. Those initially involved in this group played a significant role in establishing OR at various universities in South Africa. The OR group at CSIR did, however, continue and today the group still exists. This paper presents a brief history of this group and endeavours to provide a glimpse of some of the projects conducted over the many years since its establishment.

  20. Brief notes in advanced DSP Fourier analysis with Matlab

    CERN Document Server

    Grigoryan, Artyom M

    2009-01-01

    Based on the authors' research in Fourier analysis, Brief Notes in Advanced DSP: Fourier Analysis with MATLAB® addresses many concepts and applications of digital signal processing (DSP). The included MATLAB® codes illustrate how to apply the ideas in practice.The book begins with the basic concept of the discrete Fourier transformation and its properties. It then describes lifting schemes, integer transformations, the discrete cosine transform, and the paired transform method for calculating the discrete Hadamard transform. The text also examines the decomposition of the 1D signal by so-calle

  1. The history of Croatian Trauma Society - a brief overview.

    Science.gov (United States)

    Bakota, B; Vlahovic, T; Staresinic, M; Dobric, I; Civaric, T

    2013-09-01

    Croatian Trauma Society (CTS) has a 51 year of history and tradition. This article represents a brief overview from the times when it was founded, June 30, 1961, until the present time. It tells us about the idea how, where and when the "Section for Traumatology" was founded, its activities and influence not only to promote patient trauma care but initiation of other societies dealing with traumatized patients as well, including the evolution of the CTS itself. The authors thank to all the contributors that made this article possible.

  2. A brief account of Julius Planer's life and research

    Directory of Open Access Journals (Sweden)

    R. Bilyy

    2010-01-01

    Full Text Available A brief account of the life and research activities of Julius Planer is presented. Professor Planer is a scientist who lived one and half century ago. However, his studies, in particular, during the years when he headed Department of Anatomy at Universität in Lemberg, nowadays known as the Ivan Franko National University of Lviv in Ukraine, were essential to a modern understanding of liquid crystals. While working at Lviv University, Planer also made several landmark contributions to biomedical science.

  3. SOLUTION FOCUSED BRIEF COUNSELING (SFBC: ALTERNATIF PENDEKATAN DALAM KONSELING KELUARGA

    Directory of Open Access Journals (Sweden)

    Sumarwiyah -

    2015-11-01

    Full Text Available Solution Focused Brief Counseling meruppakan pendekatan konseling yang didasari oleh suatu pandangan bahwa sejatinya kebenaran dan realitas bukanlah suatu yang bersifat absolute namun realitas dan kebenaran itu dapat dikonstruksikan. Dalam konteks konseling keluarga dominasi salah satu anggota dana tau kepala keluarga sering menjadi pemicu masalah sehingga perlu didudukkan pada satu konteks penyelesaian masalah berbasis pada realitas yang ada. Konsleing keluarga dengan pendekatan ini memungkinkan konseli yang bermasalah dalam konteks keluarga memperoleh kemandirian dalam menyelesaikan masalah dan mencari solusi secara cepat dan tepat dalam mengatasi masalah-maslah yang ada dalam keluarga. Normal 0 false false false EN-US X-NONE X-NONE

  4. Examination of a brief Smoking Consequences Questionnaire for college students.

    Science.gov (United States)

    Schleicher, Holly E; Harris, Kari Jo; Catley, Delwyn; Harrar, Solomon W; Golbeck, Amanda L

    2008-09-01

    This study examined the factor structure of a brief version of the Smoking Consequences Questionnaire-Adult (SCQ-A) among 315 college freshman and sophomore smokers. A comparison of results from two confirmatory factor analyses demonstrated that a nine-factor model provided superior fit to a four-factor model. Furthermore, results revealed a lack of factorial invariance of factor loadings for daily and nondaily smokers, and of latent mean structures for smoking category and gender. In addition, concurrent validity tests demonstrated that positive expectancies increased with smoking rate and nicotine dependence. These results and their implications are discussed.

  5. American ASTP prime crew participate in photography mission briefing

    Science.gov (United States)

    1975-01-01

    The three American ASTP prime crew astronauts participate in a photography mission briefing in bldg 5 with Dr. Farouk El-Baz (wearing face mask) during Apollo Soyuz Test Project (ASTP) pre-flight activity at JSC. They are, left to right, Thomas P. Stafford, commander; Vance D. Brand, command module pilot; Dr. El-Baz; and Donald K. Slayton, docking module pilot. Dr. El-Baz is with the Center for Earth and Planetary Studies, National Air and Space Museum, Smithsonian Institution. The face mask is to protect the crewmen from possible exposure to disease prior to launch time.

  6. A Brief Account on the Functions of Rhetorical Repetition

    Institute of Scientific and Technical Information of China (English)

    Li Yuping

    2000-01-01

    It is believed that using rhetoric devices precisely is of great importance for the English Learners, if they want to write good articles. Repetition is one of the rhetoric devices that is frequently used in English writing. This paper gives a brief account on the four functions of repetition by presenting some typical examples, focusing the reader's attention on the significance of this device in the English writing. The following are the four functions: an effective means of emphasis; making anidea clear and easier; generating emotional force; heightening a certain atmosphere.

  7. Can the documented patient briefing be carried out with an iPad app?

    Science.gov (United States)

    Schlechtweg, Philipp Martin; Hammon, Matthias; Heberlein, Christian; Giese, David; Uder, Michael; Schwab, Siegfried Alexander

    2013-06-01

    To evaluate the feasibility of an iPad-based documented patient briefing for Magnetic Resonance Imaging (MRI) examinations. A standard briefing sheet and questionnaire for a MRI scan was converted from paper form into an iPad application. Twenty patients, who had been referred for an MRI scan, were briefed about the examination in paper form as well as via the iPad application before performing the MRI scan. Time each patient needed for the briefing and the number of questions that came up were documented. Patients' acceptance of the electronic briefing was assessed using a questionnaire. The mean processing time was 2.36 min (range 0.58 to 09.35 min., standard deviation ±2.05 min) for the paper-based briefing and 4.15 min (range 1.56 to 13.48 min, SD ± 2.36 min) for the app-based briefing. Concerning technical aspects, patients asked two questions during the app-based briefing; no questions arose during the paper-based briefing. Six patients preferred electronic briefing and four patients, the paper-based form. No patient preferred the electronic form with additional multimedial information. Eight participants did not mind which briefing version was used; two participants did not express their preference at all. Our experiences showed that electronic briefing using an iPad is feasible and has the potential to become a user-friendly alternative to the conventional paper-based approach. Owing to the broad range of the results, a follow-up study will seek to determine the influencing factors on processing time and other potential questions.

  8. Briefing Products - Tools for Communicating Technical Issues to a Non-Technical Audience

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Harvey Clark, Kevin T. Foster

    2011-06-09

    Briefing Products are a new NARAC/IMAAC product line designed to communicate the consequences of a radiological, nuclear, chemical or biological agent incident to non-technical decision makers and key leaders. Each Briefing Product addresses a single decision or issue focused on potential actions that should be considered when responding to a hazard, while avoiding the use of technical or regulatory jargon. Briefing Products do not make protective action recommendations, although they do concretely assist decision-makers with development of their own protective actions by quoting or paraphrasing the published guidance relevant to the decision at hand. Briefing Products are produced in sets tailored to specific types of incident which together depict the key decisions and characteristics of the incident. Each Briefing Product in the set consists of three elements: (1) Primary Effects, (2) Key Points and (3) Presenter Notes. Both the Primary Effects and Key Points are ready for direct presentation, while the Presenter Notes are designed to provide background information to the presenter and are not for direct presentation to the audience. The Briefing Products themselves are alternative presentations of results from the customary standard NARAC/IMAAC technical products. Currently, Briefing Products are available for detonation of both RDDs (Radiological Dispersal Devices) and INDs (Improvised Nuclear Devices). A new set of products tailored to nuclear power plant (NPP) accidents is currently under development. This paper describes the scope, structure and content of the Briefing Product sets. Examples from the two sets of Briefing Products now available are presented.

  9. Validity of brief intelligence tests for patients with Alzheimer's disease.

    Science.gov (United States)

    Nakamura, H; Nakanishi, M; Furukawa, T A; Hamanaka, T; Tokudome, S

    2000-08-01

    The validity of two kinds of brief intelligence tests for patients with Alzheimer's disease (AD) was investigated. In study 1, five short forms of the Japanese Wechsler Adult Intelligence Scale-Revised (JWAIS-R) were administered to 102 AD patients. The results showed that the intra-class correlation coefficients (ICC) between IQ estimated with the short forms and those obtained by administration of the full JWAIS-R were satisfactory, ranging from 0.82 to 0.98, and that the abbreviated forms took a shorter time to execute. In study 2, the Raven's Coloured Progressive Matrices (RCPM) and the Mini-Mental State Examination (MMSE) were administered to 67 AD patients. The ICC between the IQ estimated with these tests and the full-scale IQ of the JWAIS-R were both acceptable at 0.57, and each test could be carried out in a very short time. It was concluded that these brief tests, particularly the WAIS-R short forms, are highly practical for quick measurement of intelligence in AD patients, although they have their respective limitations.

  10. Brief Mental Training Reorganizes Large-Scale Brain Networks

    Science.gov (United States)

    Tang, Yi-Yuan; Tang, Yan; Tang, Rongxiang; Lewis-Peacock, Jarrod A.

    2017-01-01

    Emerging evidences have shown that one form of mental training—mindfulness meditation, can improve attention, emotion regulation and cognitive performance through changing brain activity and structural connectivity. However, whether and how the short-term mindfulness meditation alters large-scale brain networks are not well understood. Here, we applied a novel data-driven technique, the multivariate pattern analysis (MVPA) to resting-state fMRI (rsfMRI) data to identify changes in brain activity patterns and assess the neural mechanisms induced by a brief mindfulness training—integrative body–mind training (IBMT), which was previously reported in our series of randomized studies. Whole brain rsfMRI was performed on an undergraduate group who received 2 weeks of IBMT with 30 min per session (5 h training in total). Classifiers were trained on measures of functional connectivity in this fMRI data, and they were able to reliably differentiate (with 72% accuracy) patterns of connectivity from before vs. after the IBMT training. After training, an increase in positive functional connections (60 connections) were detected, primarily involving bilateral superior/middle occipital gyrus, bilateral frontale operculum, bilateral superior temporal gyrus, right superior temporal pole, bilateral insula, caudate and cerebellum. These results suggest that brief mental training alters the functional connectivity of large-scale brain networks at rest that may involve a portion of the neural circuitry supporting attention, cognitive and affective processing, awareness and sensory integration and reward processing.

  11. An unusual presentation of brief recurrent psychosis: a case report

    Directory of Open Access Journals (Sweden)

    Krishnamurthy CN

    2012-12-01

    Full Text Available Background: Although the term "zycloiden psychosen" was first used by Karl Kleist in 1926 to group together disorders, which had presented with sudden onset, brief episodic course, polymorphous psychotic symptoms and good inter-episode recovery, its origin can be traced back to 1880s. Despite its existence in the community, for so long, the diagnosis of cycloid psychosis is only seldom made, making it a unique disorder. Hence, there seems to be lack of awareness of this rare entity even among the psychiatrists.Case description: A middle-aged woman with abrupt onset of recurrent brief episodes of psychotic symptoms, and complete inter-episode recovery, was admitted with history of alleged consumption of poison in a state of confusion. During psychotic episodes, motility disturbances were predominant. The current episode lasted for about two weeks.Discussion: This case doesn't satisfy the criteria for schizophrenia or affective illness. Although ICD-10 describes 'acute polymorphic psychotic disorder' (F23.0, F23.1 it requires the presence of typical schizophrenic symptoms for its diagnosis and is usually not recurrent. The closest this case resembles is cycloid psychosis, meeting three of four Perris criteria.Conclusion: The diagnosis of such unusual cases of psychosis predicts the prognosis and helps in assessment and management of future episodes.

  12. A brief intervention for fatigue management in breast cancer survivors.

    Science.gov (United States)

    Fillion, Lise; Gagnon, Pierre; Leblond, Francine; Gélinas, Céline; Savard, Josée; Dupuis, Réjeanne; Duval, Karine; Larochelle, Marie

    2008-01-01

    The purpose of this randomized control trial was to verify the effectiveness of a brief group intervention that combines stress management psycho-education and physical activity (ie, independent variable) intervention in reducing fatigue and improving energy level, quality of life (mental and physical), fitness (VO 2submax), and emotional distress (ie, dependent variables) in breast cancer survivors. This study applied Lazarus and Folkman stress-coping theoretical framework, as well as Salmon's unifying theory of physical activity. Eighty-seven French-speaking women who had completed their treatments for nonmetastatic breast cancer at a university hospital in Quebec City, Canada, were randomly assigned to either the group intervention (experimental) or the usual-care (control) condition. Data were collected at baseline, postintervention, and at 3-month follow-up. The 4-week group intervention was cofacilitated by 2 nurses. Results showed that participants in the intervention group showed greater improvement in fatigue, energy level, and emotional distress at 3-month follow-up, and physical quality of life at postintervention, compared with the participants in the control group. These results suggest that a brief psycho-educational group intervention focusing on active coping strategies and physical activity is beneficial to cancer survivors after breast cancer treatments.

  13. My brief history. 2. ed.; Meine kurze Geschichte

    Energy Technology Data Exchange (ETDEWEB)

    Hawking, Stephen

    2015-11-01

    For the first time, Stephen Hawking turns his gaze inward for a revealing look at his own life and intellectual evolution. My Brief History recounts Stephen Hawking's improbable journey, from his post-war London boyhood to his years of international acclaim and celebrity. Illustrated with rarely seen photographs, this concise, witty and candid account introduces readers to the inquisitive schoolboy whose classmates nicknamed him 'Einstein'; the jokester who once placed a bet with a colleague over the existence of a black hole; and the young husband and father striving to gain a foothold in the world of academia. Writing with humility and humour, Hawking opens up about the challenges that confronted him following his diagnosis of ALS aged twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time - one of the iconic books of the twentieth century.

  14. Development of a brief version of the Pathological Narcissism Inventory.

    Science.gov (United States)

    Schoenleber, Michelle; Roche, Michael J; Wetzel, Eunike; Pincus, Aaron L; Roberts, Brent W

    2015-12-01

    With theoretical and empirical interest in narcissism growing, there is a need for brief measures of pathological narcissism that can be used more practically while assessing the construct comprehensively. Data from four samples (total N = 3,851) collected across two separate research groups and representing undergraduate, community, and clinical populations were used to establish the reliability, validity, and utility of the Brief-Pathological Narcissism Inventory (B-PNI). Item response theory and confirmatory factor analyses were used to determine the best-performing 28 items from the original PNI and ensure that the B-PNI exhibited a factor structure consistent with the original PNI. Items were retained for all seven pathological narcissism facet scales. Additional results also support the criterion validity of the B-PNI, suggesting that it can be used in place of the original PNI to assess the various facets of pathological narcissism effectively and without loss of information, which may enhance the ability of researchers to investigate pathological narcissism in future work.

  15. The potential for technology in brief interventions for substance use, and during-session prediction of computer-delivered brief intervention response

    Science.gov (United States)

    Ondersma, Steven J.; Grekin, Emily R.; Svikis, Dace

    2011-01-01

    This paper has two aims. First, we provide an overview of the potential of technology in the area of brief interventions for substance use, and describe recent projects from our lab that are illustrative of that potential. Second, we present data from a study of during-session predictors of brief intervention response. In a sample of post-partum women (N = 39), several variables showed promise as predictors of later drug use, and a brief index derived from them predicted abstinence with a sensitivity of .7 and a specificity of .89. This promising approach and initial study findings support the importance of future research in this area. PMID:21190408

  16. Brief cognitive behavior therapy in patients with social anxiety disorder: A preliminary investigation

    Directory of Open Access Journals (Sweden)

    Ravikant G Pinjarkar

    2015-01-01

    Full Text Available Context: Cognitive behavior therapy (CBT is the treatment of choice in anxiety disorders. However, there is little evidence for the effectiveness brief CBT in social anxiety. Aims: We examined the effectiveness of a brief CBT of six sessions in patients with social anxiety disorder. Settings and Design: A single case design study baseline; post and 1 month follow-up was adopted. Materials and Methods: Seven patients with a DSM IV diagnosis of social anxiety underwent 6 weekly sessions of brief CBT. Their diagnosis was confirmed using structured diagnostic interviews. They were assessed at baseline, post and 1-month follow-up on CGI- Severity, Leibowitz Social Anxiety Scale (LSAS, Social Phobia Rating Scale, Brief Fear of Negative Evaluation, and Beck′s Depression Inventory. Statistical Analysis: Data were analyzed using the method of clinical significance. Results: Results indicated that brief CBT was effective in reducing social anxiety in all patients. Brief CBT was also effective in reducing social avoidance and self consciousness. However, brief CBT was not effective in reducing fear of negative evaluation in all patients, suggesting the need for longer duration for cognitive changes in some dysfunctional beliefs. Conclusions: This preliminary case series indicates that brief CBT may be a promising and a cost and time effective approach to managing for social anxiety.

  17. School Counselors' Adoption of Brief Counseling: The Diffusion of an Innovative Practice

    Science.gov (United States)

    Littrell, John M.; Carlson, Laurie

    2009-01-01

    Brief counseling has emerged as an innovation in the field of school counseling. This study examined the factors that promote and impede the adoption of such innovation. Everett Rogers' diffusion of innovation model provided the framework for the survey examining counselors' knowledge, application skills, and actual use of brief counseling. The…

  18. Can Professional Development for Teachers Enhance Language and Literacy Environments for Preschoolers? Evaluation Science Brief

    Science.gov (United States)

    National Forum on Early Childhood Program Evaluation, 2009

    2009-01-01

    "Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study, "Building Support for Language and Literacy in Preschool Classrooms through In-Service Professional Development: Effects of the Literacy Environment Enrichment…

  19. Learning to Teach: Practice-Based Preparation in Teacher Education. Special Issues Brief

    Science.gov (United States)

    Benedict, Amber; Holdheide, Lynn; Brownell, Mary; Foley, Abigail Marshall

    2016-01-01

    This Special Issues Brief from the Collaboration for Effective Educator Development, Accountability and Reform (CEEDAR Center) and the Center on Great Teachers and Leaders (GTL Center) outlines essential features for providing high-quality, structured, and sequenced opportunities to practice within teacher preparation programs. This brief is…

  20. Student Count Mechanisms for Funding Purposes. Education Policy Brief, Volume 10, Number 2, Spring 2012

    Science.gov (United States)

    Lara, Lindsi M.; Spradlin, Terry E.; Wodicka, Christopher Y.

    2012-01-01

    This Education Policy Brief provides an overview of the student count mechanisms that are currently employed by states. It then reviews Indiana's outgoing count mechanism, the Single Count Date, and compares it with the newly enacted Multiple Count Dates mechanism. To conclude the discussion, the brief examines how other states use the Multiple…

  1. Brief narrative exposure therapy for posttraumatic stress in Iraqi refugees: a preliminary randomized clinical trial.

    Science.gov (United States)

    Hijazi, Alaa M; Lumley, Mark A; Ziadni, Maisa S; Haddad, Luay; Rapport, Lisa J; Arnetz, Bengt B

    2014-06-01

    Many Iraqi refugees suffer from posttraumatic stress. Efficient, culturally sensitive interventions are needed, and so we adapted narrative exposure therapy into a brief version (brief NET) and tested its effects in a sample of traumatized Iraqi refugees. Iraqi refugees in the United States reporting elevated posttraumatic stress (N = 63) were randomized to brief NET or waitlist control conditions in a 2:1 ratio; brief NET was 3 sessions, conducted individually, in Arabic. Positive indicators (posttraumatic growth and well-being) and symptoms (posttraumatic stress, depressive, and somatic) were assessed at baseline and 2- and 4-month follow-up. Treatment participation (95.1% completion) and study retention (98.4% provided follow-up data) were very high. Significant condition by time interactions showed that those receiving brief NET had greater posttraumatic growth (d = 0.83) and well-being (d = 0.54) through 4 months than controls. Brief NET reduced symptoms of posttraumatic stress (d = -0.48) and depression (d = -0.46) more, but only at 2 months; symptoms of controls also decreased from 2 to 4 months, eliminating condition differences at 4 months. Three sessions of brief NET increased growth and well-being and led to symptom reduction in highly traumatized Iraqi refugees. This preliminary study suggests that brief NET is both acceptable and potentially efficacious in traumatized Iraqi refugees.

  2. A Brief Comparative Study of the Translation Theories by Nida and New-mark

    Institute of Scientific and Technical Information of China (English)

    李奕

    2016-01-01

    Nida and Newmark are the two of the most distinguished contemporary translation theorist in the west. A brief compar-ative study was made on their translation theories by giving a general survey of their life, then a brief introduction of their theo-ries and comparing the differences.

  3. 20 CFR 404.975 - Filing briefs with the Appeals Council.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Filing briefs with the Appeals Council. 404.975 Section 404.975 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... and Decisions Appeals Council Review § 404.975 Filing briefs with the Appeals Council. Upon...

  4. The Effect of Brief Functional Relaxation on College Students' Needle Anxiety during Injected Vaccinations

    Science.gov (United States)

    McWhorter, Linda G.; Gil-Rivas, Virginia

    2014-01-01

    Objective: This study examined the effect of brief functional relaxation (FR) training on needle anxiety (NA) during vaccinations. Participants: From October 2010 through May 2012, 48 undergraduates were recruited through the psychology research participant pool. Methods: Students (N = 48) were randomly assigned to a 15-minute brief FR session…

  5. Brief, Early Treatment for ASD/PTSD Following Motor Vehicle Accidents

    Science.gov (United States)

    Hickling, Edward J.; Blanchard, Edward B.; Kuhn, Eric

    2005-01-01

    Early, brief interventions for posttraumatic stress disorder (PTSD) secondary to motor vehicle accidents (MVAs) have historically been, with few exceptions, unsuccessful with single session or even very brief (3 to 6 sessions) interventions. In contrast, very intensive cognitive behavioral therapy (CBT) applied over the first 6 to 8 weeks…

  6. Building Literacy in Afterschool. Dollar General Afterschool Literacy Issue Brief. No. 67

    Science.gov (United States)

    Afterschool Alliance, 2015

    2015-01-01

    The Afterschool Alliance, in partnership with Dollar General Literacy Foundation, is proud to present this issue brief examining the vital role afterschool programs play to build students' literacy skills. This issue brief will explore the additional support needed to help students with their reading, writing and critical thinking skills, as well…

  7. Conceptualizing an Agenda for Social Responsibility and Public Policy at Montgomery College. A Briefing Paper. Revised

    Science.gov (United States)

    Scott, Michelle T.

    2007-01-01

    The purpose of this briefing paper is to conceptualize a social responsibility and public policy agenda for Montgomery College. The briefing paper provides (a) a well researched perspective to embed a College culture to actualize social responsibility and public policy as institutional practices; (b) examines some of the opportunities and…

  8. Screening High School Students for Eating Disorders: Validity of Brief Behavioral and Attitudinal Measures

    Science.gov (United States)

    Haines, Jess; Ziyadeh, Najat J.; Franko, Debra L.; McDonald, Julia; Mond, Jonathan M.; Austin, S. Bryn

    2011-01-01

    Background: Early identification can greatly impact the trajectory of eating disorders, and school-based screening is 1 avenue for identifying those at risk. To be feasible in a school setting, a screening program must use a brief, valid screening tool. The aim of this study was to assess how well brief attitudinal and behavioral survey items…

  9. Equity and Early Childhood Education: Reclaiming the Child. A Research Policy Brief

    Science.gov (United States)

    National Council of Teachers of English, 2016

    2016-01-01

    Equity can be described as the elimination of privilege, oppression, disparities, and disadvantage that historically have excluded those belonging to particular groups. This is the first and overarching of several research policy briefs around issues of equity. When taken as a whole, these briefs will create a space and open a dialogue around the…

  10. High-Quality Professional Development for All Teachers: Effectively Allocating Resources. Research & Policy Brief

    Science.gov (United States)

    Archibald, Sarah; Coggshall, Jane G.; Croft, Andrew; Goe, Laura

    2011-01-01

    This Research & Policy Brief addresses the aspect of the teacher support system that is perhaps the most important and often the most weakly implemented: teacher learning and development. This brief includes the following to help state and district leaders select professional learning activities that are worth the allocation of scarce resources:…

  11. Clinicians' Perspectives on Motivational Interviewing-Based Brief Interventions in College Health

    Science.gov (United States)

    Rash, Elizabeth M.

    2008-01-01

    Brief interventions based on motivational interviewing (MI) are emerging as effective strategies for behavior change in college students. However, implementation of MI-based brief interventions may be challenging in the college health environment, and their practicality is controversial. The author explored college health clinicians' perspectives…

  12. Kentucky Child Poverty, 2000: One in Four Children Is Poor. Census Brief: Child Poverty in Kentucky.

    Science.gov (United States)

    Graycarek, Rick; Hoye, Kathleen

    This census brief examines changes in the child poverty rate during the 1990s for the state of Kentucky. The brief notes that more than one in four children in Kentucky is living in poverty, with nearly half of Kentucky's children living in families that are not financially self-sufficient. The majority of poor children live in urban areas, most…

  13. Studying Child Care Subsidies with Secondary Data Sources. Methodological Brief OPRE 2012-54

    Science.gov (United States)

    Ha, Yoonsook; Johnson, Anna D.

    2012-01-01

    This brief describes four national surveys with data relevant to subsidy-related research and provides a useful set of considerations for subsidy researchers considering use of secondary data. Specifically, this brief describes each of the four datasets reviewed, highlighting unique features of each dataset and providing information on the survey…

  14. Developing a Student Centred Approach to Practice Placement Briefings and Debriefings

    Science.gov (United States)

    Callister, Georgina M.

    2007-01-01

    This research developed from the recognition that work-based placement briefing and debriefing sessions need to encourage reflection and student self-directed learning. An action research methodology was used to obtain students views of the value of briefing and debriefing sessions. Changes to session format were introduced and then in response to…

  15. Ten Year Revision of the Brief Behavioral Activation Treatment for Depression: Revised Treatment Manual

    Science.gov (United States)

    Lejuez, C. W.; Hopko, Derek R.; Acierno, Ron; Daughters, Stacey B.; Pagoto, Sherry L.

    2011-01-01

    Following from the seminal work of Ferster, Lewinsohn, and Jacobson, as well as theory and research on the Matching Law, Lejuez, Hopko, LePage, Hopko, and McNeil developed a reinforcement-based depression treatment that was brief, uncomplicated, and tied closely to behavioral theory. They called this treatment the brief behavioral activation…

  16. A Brief Report on a Major International Sociological Conference

    Directory of Open Access Journals (Sweden)

    FILIP M. ALEXANDRESCU

    2011-02-01

    Full Text Available This paper offers a brief presentation of the resettlement conference entitled "Economics, Social Justice, and Ethics in Development-Caused Involuntary Migration" that took place in the Hague from October 4th to 8th, 2010, as part of the broader 15th Metropolis Conference. The focus of the paper is on the contents of this high-level scientific event as well as on the broader concerns animating the community of resettlement researchers, namely the problems of economics, ethics and social justice in involuntary resettlement processes. In this context, the trailblazing contributions of Professor Michael Cernea as well as his enthusiasm and constant encouragement for young researchers are singled out for special attention.

  17. National briefing summaries: Nuclear fuel cycle and waste management

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K.J.; Lakey, L.T.; Silviera, D.J.

    1988-12-01

    The National Briefing Summaries is a compilation of publicly available information concerning the nuclear fuel cycle and radioactive waste management strategies and programs of 21 nations, including the United States and three international agencies that have publicized their activities in this field. It presents available highlight information with references that may be used by the reader for additional information. The information in this document is compiled primarily for use by the US Department of Energy and other US federal agencies and their contractors to provide summary information on radioactive waste management activities in other countries. This document provides an awareness to managers and technical staff of what is occurring in other countries with regard to strategies, activities, and facilities. The information may be useful in program planning to improve and benefit United States' programs through foreign information exchange. Benefits to foreign exchange may be derived through a number of exchange activities.

  18. Memory for brief, widely spaced odor presentations in the rat.

    Science.gov (United States)

    Lovelace, C T; Slotnick, B M

    1995-04-01

    Rats trained on a series of 16 novel 2-odor discrimination tasks using a 10-s intertrial interval (ITI) rapidly improved in performance and made only 0-3 errors by the end of the test series. They were then tested on other novel pairs of odors, but with a 10- and a 30-min interval between trials. There was no decrement in performance accuracy in the longer ITI tests and, in most cases, criterion performance was achieved after making zero or 1 error after the first (information) trial. These results demonstrate that rats have the capacity to remember for at least 30 min whether a single brief presentation of a novel odor was followed by a reward.

  19. Brief Behavioral Treatment for Insomnia in Persons Living with HIV.

    Science.gov (United States)

    Buchanan, Diana Taibi; McCurry, Susan M; Eilers, Kristi; Applin, Shauna; Williams, Ellita T; Voss, Joachim G

    2016-06-30

    This study examined the feasibility and preliminary efficacy of brief behavioral treatment for insomnia (BBTI) for persons living with HIV (PLWH). Of the 22 persons enrolled, 9 were lost before starting treatment, and one dropped out after starting BBTI. Acceptability was rated favorably by those completing the treatment (n = 12). The most common problems pertained to sleep hygiene: variable bedtimes and rise times, watching television, or consuming caffeine. Improvements on sleep outcomes at posttreatment were clinically and statistically significant on questionnaire and sleep diary outcomes. This study supports the overall feasibility of BBTI in PLWH, and the preliminary evidence supports further research on this treatment for PLWH who have insomnia, but dropouts indicate that some individuals may have difficulty initiating treatment.

  20. 2015 Relaunch as Open Access Pediatric Neurology Briefs

    Directory of Open Access Journals (Sweden)

    John J Millichap

    2015-01-01

    Full Text Available Pediatric Neurology Briefs (PNB has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology. In 2015, PNB is relaunched as an open access, peer-reviewed, journal with an expanded editorial board.  PNB has a new website and content management system capable of organizing peer-review and providing improved indexing, DOI assignment, and online full-text article view.  Digitization of back issues, archiving, and inclusion in PubMed are future goals.  The new online open access PNB aims to reach more physicians, researchers, and other healthcare providers with highlights of the latest advances in pediatric neurology and commentaries by specialists in the field.

  1. 2015 Relaunch as Open Access Pediatric Neurology Briefs.

    Science.gov (United States)

    Millichap, John J; Millichap, J Gordon

    2015-01-01

    Pediatric Neurology Briefs (PNB) has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology. In 2015, PNB is relaunched as an open access, peer-reviewed, journal with an expanded editorial board. PNB has a new website and content management system capable of organizing peer-review and providing improved indexing, DOI assignment, and online full-text article view. Digitization of back issues, archiving, and inclusion in PubMed are future goals. The new online open access PNB aims to reach more physicians, researchers, and other healthcare providers with highlights of the latest advances in pediatric neurology and commentaries by specialists in the field.

  2. THE IX EUROPEAN FORUM ON ANTIPHOSPHOLIPID ANTIBODIES. A BRIEF REVIEW

    Directory of Open Access Journals (Sweden)

    Nataliya V Seredavkina

    2014-01-01

    Full Text Available The article presents a brief review of the proceedings of the IX European Forum on antiphospholipid antibodies held in May 2013 in Krakow (Poland. The aim of the Forum is to coordinate multicenter projects focused on antiphospholipid antibodies (aPL, both clinical and fundamental research, based on cooperation between the European countries. The main purpose is to stimulate research into all aspects of aPL, to facilitate the exchange of information between institutions, and to involve many centers in different countries into scientific research on this issue. The issues of standardization of the diagnostic criteria for antiphospholipid syndrome (APS, primarily serological markers (their specificity, sensitivity and correlation with clinical manifestations, as well as non-criterial manifestations of APS, were considered at the meeting. In addition, the therapy problems were discussed.

  3. Mixing, spreading and reaction in heterogeneous media: a brief review.

    Science.gov (United States)

    Dentz, Marco; Le Borgne, Tanguy; Englert, Andreas; Bijeljic, Branko

    2011-03-01

    Geological media exhibit heterogeneities in their hydraulic and chemical properties, which can lead to enhanced spreading and mixing of the transported species and induce an effective reaction behavior that is different from the one for a homogeneous medium. Chemical heterogeneities such as spatially varying adsorption properties and specific reactive surface areas can act directly on the chemical reaction dynamics and lead to different effective reaction laws. Physical heterogeneities affect mixing-limited chemical reactions in an indirect way by their impact on spreading and mixing of dissolved species. To understand and model large-scale reactive transport the interactions of these coupled processes need to be understood and quantified. This paper provides a brief review on approaches of non-reactive and reactive transport modeling in geological media.

  4. A Brief Overview of the Civil Union Act

    Directory of Open Access Journals (Sweden)

    N Ntlama

    2010-05-01

    Full Text Available The adoption of the Constitution of the Republic of South Africa, 1996 (the Constitution has provided a sound framework for the elimination of discrimination and prejudice against all members of our society. The Constitution provides for equal recognition of the right to freedom of religion and sexual orientation within the framework of the right to equality. This note aims to provide a brief overview and analysis of the general and potentially problematic features of the Civil Union Act 17 of 2006 (the Act in the context of equality, generally and within realm of the constitutional protection afforded to everyone in South Africa. This contribution is limited to an examination of the quality of the legal protection accorded to same-sex couples as envisaged inthe Act, and not to an analysis of the nature of the institution of marriage itself or the theological and social dimensions of same-sex marriages.

  5. Energy predictions. [Briefs on 33 charts, figures, and graphs

    Energy Technology Data Exchange (ETDEWEB)

    Freiwald, D.A.

    1977-01-01

    Briefs describe 33 charts, graphs, and schematics offering some recent history and perspectives on the world and U.S. energy situation and the problems for survival facing the world. Of interest is Figure 28, showing the Club of Rome's model of the earth in terms of resource consumption, food, money, people, pollution, etc. A computer was asked to extend recent history into the future and results indicate a collapse of the industrialized system towards an agrarian culture around the year 2025. It is noted that the model did not consider technological initiative or man's willingness to change lifestyles. The final (33) schematic is a guesstimate of noticeable impact timescales, indicating when research projects on transition or ultimate energy sources at LASL might be expected to yield impact. (MCW)

  6. National briefing summaries: Nuclear fuel cycle and waste management

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K.J.; Bradley, D.J.; Fletcher, J.F.; Konzek, G.J.; Lakey, L.T.; Mitchell, S.J.; Molton, P.M.; Nightingale, R.E.

    1991-04-01

    Since 1976, the International Program Support Office (IPSO) at the Pacific Northwest Laboratory (PNL) has collected and compiled publicly available information concerning foreign and international radioactive waste management programs. This National Briefing Summaries is a printout of an electronic database that has been compiled and is maintained by the IPSO staff. The database contains current information concerning the radioactive waste management programs (with supporting information on nuclear power and the nuclear fuel cycle) of most of the nations (except eastern European countries) that now have or are contemplating nuclear power, and of the multinational agencies that are active in radioactive waste management. Information in this document is included for three additional countries (China, Mexico, and USSR) compared to the prior issue. The database and this document were developed in response to needs of the US Department of Energy.

  7. Biofield therapies in cardiovascular disease management: a brief review.

    Science.gov (United States)

    Anderson, Joel G; Taylor, Ann Gill

    2011-01-01

    Though there have been advances over the last 30 years in the therapeutic approaches to cardiovascular disease (CVD), heart disease and stroke remain the leading cause of mortality and morbidity worldwide. Many medical therapies for CVD are associated with a number of side effects, often leading patients to seek non-pharmacological treatments to complement standard care. Referred to as complementary and alternative medicine (CAM), these therapies consist of a heterogeneous group of modalities used in addition to conventional health care. Biofield therapies exist within this CAM domain and involve the direction of healing energy to facilitate general health and well-being by modifying the energy field. What follows is a brief overview of three biofield therapies developed or used within the field of nursing (Therapeutic Touch, Reiki, and Healing Touch), surveying the use of these interventions for individuals with CVD, and outcomes that may impact CVD risk factors and health-related quality of life.

  8. OBESITY: CHALLENGES TO VENTILATORY CONTROL DURING EXERCISE A BRIEF REVIEW

    Science.gov (United States)

    Babb, Tony G.

    2013-01-01

    Obesity is a national health issue in the US. Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in breathing mechanics. These challenges to ventilatory control in obesity can be inconspicuous or overt among obese adults but for the most part adaptation of ventilatory control during exercise in obesity appears remarkably unnoticed in the majority of obese people. In this brief review, the changes to ventilatory control required for maintaining normal ventilation during exercise will be examined, especially the interaction between respiratory neural drive and ventilation. Also, gaps in our current knowledge will be discussed. PMID:23707540

  9. Applications of Fuzzy Logic in Image Processing – A Brief

    Directory of Open Access Journals (Sweden)

    Mahesh Prasanna K

    2015-10-01

    Full Text Available  The subject of this study is to show the application of fuzzy logic in image processing with a brief introduction to fuzzy logic and digital image processing. Digital image processing is an ever expanding and dynamic area with applications reaching out into our everyday life such as medicine, space exploration, surveillance, authentication, automated industry inspection and many more areas. Fuzzy logic, one of the decision-making techniques of artificial intelligence, has many application areas. Although it has been subjected to criticisms since its birth, especially in recent years, fuzzy logic has been proven to be applicable in almost all scientific fields. This shows that the concept of fuzzy logic will maintain its validity and the number of fields where it draws attention will increase further.

  10. A brief history of plastic surgery in Iran.

    Science.gov (United States)

    Kalantar-Hormozi, Abdoljalil

    2013-03-01

     Although the exact time of performing plastic surgery is not addressed in the medical and historical literature, it can be supposed that these surgical procedures have a long and fascinating history.  Recent excavations provided many documents regarding the application of medical instruments, surgical and even reconstructive procedures during the pre-historic and ancient periods. Actually, there is no historical definite time-zone separating general and cosmetic operations in the pre-modern time; however, historically there have been many surgeons who tried to perform reconstructive procedures during their usual medical practice. This article presents a brief look at the history of plastic surgery form the ancient to the contemporary era, with a special focus on Iran.

  11. A Brief Investigation of Pre-reading Exercises in SEFC

    Institute of Scientific and Technical Information of China (English)

    XU Chu-juan

    2015-01-01

    As in reading teaching, schema theory has long been taking a dominant part. According to this theory, English teachers can help the students to call up their prior knowledge by placing an emphasis on a more efficient use of pre-reading activities. One of the effective activities is to make good use of the pre-reading exercises in the textbook. This paper intends to analyze the results of two brief investigations. One was about the pre-reading exercises in the SEFC (New Edition 2010) Book 1 . The other was car⁃ried out among the first year students from Nanhai Experimental High School of South China Normal University. English teachers in high school thus can train the students to make links between the text and what they already know according to their interests.

  12. Brief guidelines for methods and statistics in medical research

    CERN Document Server

    Ab Rahman, Jamalludin

    2015-01-01

    This book serves as a practical guide to methods and statistics in medical research. It includes step-by-step instructions on using SPSS software for statistical analysis, as well as relevant examples to help those readers who are new to research in health and medical fields. Simple texts and diagrams are provided to help explain the concepts covered, and print screens for the statistical steps and the SPSS outputs are provided, together with interpretations and examples of how to report on findings. Brief Guidelines for Methods and Statistics in Medical Research offers a valuable quick reference guide for healthcare students and practitioners conducting research in health related fields, written in an accessible style.

  13. Theoretical development of information science: A brief history

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2016-01-01

    This paper presents a brief history of information science (IS) as viewed by the author. The term ‘information science’ goes back to 1955 and evolved in the aftermath of Claude Shannon’s ‘information theory’ (1948), which also inspired research into problems in fields of library science...... and documentation. These subjects were a main focus of what became established as ‘information science’, which from 1964 onwards was often termed ‘library and information science’ (LIS). However, the usefulness of Shannon’s information theory as the theoretical foundation of the field was been challenged. Among....... Today information science is very fragmented, but a growing number of researchers find that the problems in the field should be related to theories of knowledge and understood from a social and cultural perspective, thereby re-establishing connections with idea’s such as social epistemology which may...

  14. Brief review of the state of art in futsal.

    Science.gov (United States)

    Beato, Marco; Coratella, Giuseppe; Schena, Federico

    2016-04-01

    Futsal (the official name of "five side indoor football") has become very popular in recent years, and it counts more than 12 million players in over 100 countries. Futsal is played on a field of 40 x 20 m between 2 teams of 5 players, (four outfield players and the goalkeeper). Despite its rise of popularity, the number of scientific studies related to training modalities as the demands of the match or factors linked to the performance, are quite limited. This brief review aims to explore the few papers published on futsal, taking in consideration some conclusions that can be drawn from previous studies related only to futsal and indoor football players. Future studies should examine the physical demands during the matches, the variation of physical performances during the season and compare different classic training modalities to sport specific exercises, aiming to improve the current knowledge for coaching.

  15. A Brief Review of Chelators for Radiolabeling Oligomers

    Directory of Open Access Journals (Sweden)

    Yuxia Liu

    2010-05-01

    Full Text Available The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99mTc, 111In and 188Re. While DNA and its analogs have been radiolabeled with important radionuclides of nonmetals such as 32P, 35S, 14C, 18F and 125I, the labeling methods for these isotopes involve covalent chemistry that is quite distinct from the coordinate-covalent chelation chemistry described herein. In this review, we provide a summary of the several chelators that have been covalently conjugated to oligomers for the purpose of radiolabeling with metallic radionuclides by chelation and including details on the conjugation, the choice of radionuclides and labeling methods.

  16. Reaction rate oscillations during catalytic CO oxidation: A brief overview

    Science.gov (United States)

    Tsotsis, T. T.; Sane, R. C.

    1987-04-01

    It is not the intent here to present a comprehensive review of the dynamic behavior of the catalytic oxidation of CO. This reaction is one of the most widely studied in the field of catalysis. A review paper by Engel and Ertl has examined the basic kinetic and mechanistic aspects, and a comprehensive paper by Razon and Schmitz was recently devoted to its dynamic behavior. Those interested in further study of the subject should consult these reviews and a number of general review papers on catalytic reaction dynamics. The goal is to present a brief overview of certain interesting aspects of the dynamic behavior of this reaction and to discuss a few questions and issues, which are still the subject of study and debate.

  17. Brief, embedded, spontaneous metacognitive talk indicates thinking like a physicist

    Science.gov (United States)

    Sayre, Eleanor C.; Irving, Paul W.

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think thinking like a physicist entails. Through discourse analysis of upper-division students' speech in natural settings, we show that students may appropriate or resist these elements. We identify a new element in the physicist speech genre: brief, embedded, spontaneous metacognitive talk (BESM talk). BESM talk communicates students' in-the-moment enacted expectations about physics as a technical field and a cultural endeavor. Students use BESM talk to position themselves as physicists or nonphysicists. Students also use BESM talk to communicate their expectations in four ways: understanding, confusion, spotting inconsistencies, and generalized expectations.

  18. A brief description of Polanco`s hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Ventura [Instituto de Ingenieria Electrica, Universidad de la Republica, Montevideo (Uruguay)

    1997-12-31

    Since 1995, a hybrid system wind - PV is in service in Polanco, Uruguay. A brief description of this system and the criteria employed in its design are outlined. The experience obtained during two years operation are described from the points of view of the equipment reliability and of the electrical service provided. Future prospects of this kind of installations in Uruguay as part of the rural electrification policy are presented. [Espanol] Desde 1995 esta en servicio en Polanco, Uruguay un sistema hibrido viento-fotovoltaico. Aqui se describe brevemente este sistema y el criterio empleado en su diseno. Se describe la experiencia obtenida durante dos anos de operacion desde el punto de vista de confiabilidad de los equipos y del servicio electrico proporcionado. Se presentan prospectos futuros de esta clase de instalaciones en Uruguay, como parte de la politica de electrificacion rural.

  19. Oseltamivir resistance in swine influenza: a brief discussion

    Directory of Open Access Journals (Sweden)

    Viroj Wiwanitkit

    2009-08-01

    Full Text Available Swine flu, an atypical H1N1 influenza virus infection, is a new emerging infectious disease starting from Mexico in 2009, and is presently pandemic around the world. For treatment of this infection, oseltamivir is recommended as drug of choice. Generally, a big problem for using oseltamivir in treatment of classical H1NI influenza virus infection is drug resistance. In this brief paper, the author discusses on the situation of oseltamivir resistance in swine influenza. Briefly, the oseltamivir resistance of swine flu is expected to be possible due to many underlying factors. It is needed to perform surveillance on oseltamivir resistance in swine flu. Planning for management of case of emerging oseltamivir drug resistance is needed.

  20. Brief, embedded, spontaneous metacognitive talk indicates thinking like a physicist

    CERN Document Server

    Sayre, Eleanor C

    2014-01-01

    Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think "thinking like a physicist" entails. Through discourse analysis of upper-division students' speech in natural settings, we show that students may appropriate or resist these elements. We identify a new element in the physicist speech genre: brief, embedded, spontaneous metacognitive talk (BESM talk). BESM talk communicates students' in-the-moment enacted expectations about physics as a technical field and a cultural endeavor. Students use BESM talk to position themselves as physicists or non-physicists. Students also use BESM talk to communicate their expectations in four ways: understanding, confusion, spotting inconsistencies, and generalized expectations.

  1. Quarterly Briefing Book on Environmental and Waste Management Activities

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.C.

    1991-06-01

    The purpose of the Quarterly Briefing Book on Environmental and Waste Management Activities is to provide managers and senior staff at the US Department of Energy-Richland Operations Office and its contractors with timely and concise information on Hanford Site environmental and waste management activities. Each edition updates the information on the topics in the previous edition, deletes those determined not to be of current interest, and adds new topics to keep up to date with changing environmental and waste management requirements and issues. Section A covers current waste management and environmental restoration issues. In Section B are writeups on national or site-wide environmental and waste management topics. Section C has writeups on program- and waste-specific environmental and waste management topics. Section D provides information on waste sites and inventories on the site. 15 figs., 4 tabs.

  2. EU TYPE OF AUSTERITY: BRIEF ANALYSIS AND CRITICISM

    Directory of Open Access Journals (Sweden)

    IONELA BALTATESCU

    2014-11-01

    Full Text Available Although it has become a common place to blame austerity policies for lengthening the economic downturn of EU economies, the figures reveal that public spending increased in most of the EU countries between 2007 and 2013. Although budget deficits from EU countries were indeed reduced in the last 4 years, the cutbacks were more the result of increasing government revenues and hiking taxes than of decreasing public expenditures. The article will feature: (1 a brief analysis of the evolution of public spending compared to government revenues in EU countries and also, (2 a concise literature review on austerity, highlighting some of the most important theoretical controversies on this topic. The main thesis defended in the article is that – although EU type of austerity, narrowly focusing on fiscal consolidation, drove indeed to unfavorable economic consequences – the criticism formulated by pro stimulus economists is rather flimsy, given the fact that public expenditures actually increased in most of the EU countries.

  3. Understanding hospitality house guests' needs: a brief case report.

    Science.gov (United States)

    Duncan, Mary Katherine Waibel

    2011-08-01

    A.E. Kazak's (2006) call to develop theory-driven and empirically supported programs aimed at strengthening the competencies of families affected by pediatric illness applies to both medical and nonmedical facilities and institutions that care for pediatric patients and their loved ones. M.K.W. Duncan and A. Blugis (in press, this issue) note that despite the intuitive and practical nature of Maslow's Hierarchy of Needs, no theory translates into an infallible understanding of any individual guest's needs or a program of universally applied best practice standards for meeting those needs. Using Maslow's theory as a framework, this brief report describes the complexity and fluidity of one mother's needs during her stay at a hospitality house following the birth of her premature twin babies.

  4. Credibility judgments in web page design - a brief review.

    Science.gov (United States)

    Selejan, O; Muresanu, D F; Popa, L; Muresanu-Oloeriu, I; Iudean, D; Buzoianu, A; Suciu, S

    2016-01-01

    Today, more than ever, knowledge that interfaces appearance analysis is a crucial point in human-computer interaction field has been accepted. As nowadays virtually anyone can publish information on the web, the credibility role has grown increasingly important in relation to the web-based content. Areas like trust, credibility, and behavior, doubled by overall impression and user expectation are today in the spotlight of research compared to the last period, when other pragmatic areas such as usability and utility were considered. Credibility has been discussed as a theoretical construct in the field of communication in the past decades and revealed that people tend to evaluate the credibility of communication primarily by the communicator's expertise. Other factors involved in the content communication process are trustworthiness and dynamism as well as various other criteria but to a lower extent. In this brief review, factors like web page aesthetics, browsing experiences and user experience are considered.

  5. A Brief Analysis to the 3-Step Translation Process

    Institute of Scientific and Technical Information of China (English)

    丘胜祥

    2009-01-01

    With the development of science and technology,the culture of translation still is multiplied continuously.However.how can you translate a good target text quickly and accurately?We should master transhtion skills and seep basic steps in translating.As the matter of fact,translation is expressed language actives through using a language to another language exchanged with the accuracy and integrity of thinking.Some call it an art,and yet some others take it as a career.but no matter what the purpose is,the process oftranslation has its certain steps.A translator will have to understand the source text fust.and then conduct her/his translation and then,proofread the source text.In addition,translation standard,which is Faithfulness,Expressiveness,Elegance,phy an important role in the translation process.A brief analysis of the problems mentioned above is made.

  6. A Brief Assessment for HIV Risk: The TCU HVHP Form

    Science.gov (United States)

    Rowan, Grace A.; Joe, George W.; Lehman, Wayne E. K.; Knight, Kevin

    2016-01-01

    Targeted HIV screens may help identify some risk-related concerns of drug-using offenders. The present study describes the Texas Christian University HIV/Hepatitis Risk Assessment (TCU HVHP) form, a 19-item self-report instrument measuring HIV and hepatitis risks based on a sample (N = 1,056) of offenders in eight prisons. Principal components analysis indicated four scales (Injection Risk, Condom Attitudes, Sex Risk, and AIDS Concern) with reliable psychometric properties with coefficient α reliabilities ranging from .72 to .88. Concurrent validities indicated the four scales were related to motivation for treatment, level of drug use, psychosocial functioning, and criminal thinking, although the patterns varied by gender. The TCU HVHP Form should be attractive to programs needing a brief assessment measuring HIV risk behaviors, attitudes toward condom use, and concerns about acquiring and transmitting HIV. PMID:27302708

  7. Bourdieu at the bedside: briefing parents in a pediatric hospital.

    Science.gov (United States)

    LeGrow, Karen; Hodnett, Ellen; Stremler, Robyn; McKeever, Patricia; Cohen, Eyal

    2014-12-01

    The philosophy of family-centered care (FCC) promotes partnerships between families and staff to plan, deliver, and evaluate services for children and has been officially adopted by a majority of pediatric hospitals throughout North America. However, studies indicated that many parents have continued to be dissatisfied with their decision-making roles in their child's care. This is particularly salient for parents of children with chronic ongoing complex health problems. These children are dependent upon medical technology and require frequent hospitalizations during which parents must contribute to difficult decisions regarding their child's care. Given this clinical issue, an alternative theoretical perspective was explored to redress this problem. Pierre Bourdieu's theoretical concepts of field, capital, and habitus were used to analyze the hierarchical relationships in pediatric acute care hospitals and to design a briefing intervention aimed at improving parents' satisfaction with decision making in that health care setting.

  8. Brief behavioral treatment for patients with treatment-resistant insomnia

    Directory of Open Access Journals (Sweden)

    Wang J

    2016-08-01

    Full Text Available Jihui Wang, Qinling Wei, Xiaoli Wu, Zhiyong Zhong, Guanying Li Department of Psychiatry, The Third Affiliated Hospital of Sun-Yat Sen University, Guangzhou, Guangdong, People’s Republic of China Objective: To evaluate the efficacy of brief behavioral treatment for insomnia (BBTI in treating patients with treatment-resistant insomnia.Methods: Seventy-nine adults with treatment-resistant insomnia were randomly assigned to receive either individualized BBTI (delivered in two in-person sessions and two telephone “booster” sessions, n=40 or sleep hygiene education (n=39. The primary outcome was sub­jective (sleep diary measures of self-report symptoms and questionnaire measures of Pittsburgh sleep quality index (PSQI, insomnia severity index (ISI, Epworth sleeping scale (ESS, and dysfunctional beliefs and attitudes about sleep scale (DBAS.Results: The repeated-measures analysis of variance showed significant time effects between pretreatment and posttreatment in the scale ratings of PSQI, ESS, DBAS, ISI, sleep latency (SL, time in bed (TIB, sleep efficiency (SE, and wake after sleep onset (WASO in both groups and group × time interaction (FPSQI =3.893, FESS =4.500, FDBAS =5.530, FISI =15.070, FSL =8.909, FTIB =7.895, FSE =2.926, and FWASO =2.595. The results indicated significant differences between BBTI and sleep hygiene in change scores of PSQI, ESS, DBAS, ISI, SL, TIB, SE, and WASO. Effect sizes were moderate to large.Conclusion: BBTI is a simple and efficacious intervention for chronic insomnia in adults. Keywords: brief behavioral treatment, treatment-resistant, insomnia

  9. Policy Brief: Shale Gas in India: Look Before You Leap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-15

    Natural gas forms 9 per cent of the total commercial energy mix in India, but demand far exceeds supply, as shown in Figure 1. Part of the demand in 2012–13 was made up by the import of liquefied natural gas (LNG) to the extent of 18 bcm. Several power plants, which were in operation, or ready for commissioning, or in an advanced state of construction, representing about 10,000 MW of generation capacity, were, however, idle for want of gas. The exploration and production of shale gas in the United States (US) has been a game changer, making the country self-sufficient in natural gas over the last few years. This has created considerable excitement globally, particularly in Europe. India is also looking at exploring shale gas domestically to fill in the supply–demand gap. But will what works for the US also work for Europe and India? This policy brief explores this question in the context of India. It explains the nature of shale gas, the technology for its extraction from underground sources, and its potential for India. It also highlights overseas acquisitions of this resource by Indian companies even before it is sourced domestically, and then examines the viability of the technology in India. One of the key determinants of the viability of this technology is the availability of large quantities of clean water. This policy brief raises a red flag on this complementary input for exploiting shale gas resources in India, given that India is a water stressed country, and is fast approaching water scarcity conditions.

  10. Screening and brief intervention for alcohol and other abuse.

    Science.gov (United States)

    Harris, Sion Kim; Louis-Jacques, Jennifer; Knight, John R

    2014-04-01

    Substance use is the most common health risk behavior among adolescents and is one of the greatest threats to their current and future health. Universal screening of adolescents in general medical settings can be instrumental in identifying substance use early, before further problems develop and when BIs are more likely to be effective. Screening in and of itself may have some therapeutic effect. Brief screening tools feasible for use by busy medical offices to quickly and reliably assess adolescent risk for a substance use disorder now are available. A recent study found that a physician-conducted CRAFFT screen interview required an average of 74 seconds to complete, whereas a computer self-administered version took an average of 49 seconds. The CRAFFT and AUDIT tools currently have the most evidence for validity among adolescents, whereas the validity of other widely used tools such as DAST-10, NIDA-modified ASSIST (Alcohol, Smoking and Substance Involvement Screening Test), and ultra-brief screens (AUDIT-C, single-item screens) has yet to be established for adolescents. Studies are needed to identify effective strategies to promote universal adolescent screening and the use of valid screening tools in general medical settings. One statewide (Massachusetts) study found that although most (86%) primary care physicians seeing adolescents reported screening adolescents for substance use annually, only 1 in 3 reported using a validated tool (the CRAFFT). The remaining physicians reporting using informal screening procedures, their own questionnaire, or the CAGE. Computerization of screening and integration into the electronic health record appear to be promising strategies to promote universal screening and standardized use of valid screening tools. Increasing adolescent screening rates necessitates supporting physicians' ability to respond effectively to the screen results. To that end, recent evidence-informed practice guides from the AAP and NIAAA provide a

  11. Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors.

    Science.gov (United States)

    Chang, Chun Yun; Esber, Guillem R; Marrero-Garcia, Yasmin; Yau, Hau-Jie; Bonci, Antonello; Schoenbaum, Geoffrey

    2016-01-01

    Correlative studies have strongly linked phasic changes in dopamine activity with reward prediction error signaling. But causal evidence that these brief changes in firing actually serve as error signals to drive associative learning is more tenuous. Although there is direct evidence that brief increases can substitute for positive prediction errors, there is no comparable evidence that similarly brief pauses can substitute for negative prediction errors. In the absence of such evidence, the effect of increases in firing could reflect novelty or salience, variables also correlated with dopamine activity. Here we provide evidence in support of the proposed linkage, showing in a modified Pavlovian over-expectation task that brief pauses in the firing of dopamine neurons in rat ventral tegmental area at the time of reward are sufficient to mimic the effects of endogenous negative prediction errors. These results support the proposal that brief changes in the firing of dopamine neurons serve as full-fledged bidirectional prediction error signals.

  12. Uptake of a team briefing in the operating theatre: a Burkean dramatistic analysis.

    Science.gov (United States)

    Whyte, Sarah; Cartmill, Carrie; Gardezi, Fauzia; Reznick, Richard; Orser, Beverley A; Doran, Diane; Lingard, Lorelei

    2009-12-01

    Communication among healthcare professionals is a focus for research and policy interventions designed to improve patient safety, but the challenges of changing interprofessional communication patterns are rarely described. We present an analysis of 756 preoperative briefings conducted by general surgery teams (anesthesiologists, nurses, and surgeons) at four urban Canadian hospitals in the context of two research studies conducted between August 2004 and December 2007. We ask the questions: how and why did briefings succeed, how and why did they fail, and what did they mean for different participants? Ethnographic fieldnotes documenting the coordination and performance of team briefings were analyzed using Kenneth Burke's concepts of motive and attitude. The language and behaviour of participants were interpreted as purposive and situated actions which reveal perceptions, beliefs and values. Motives and attitudes varied both within and across sites, professions, individuals, and briefings. They were contingent on the organizational, medical and social scenes in which the briefings took place and on participants' multiple perceived purposes for participating (protecting patient safety, exchanging information, engaging with the team, fulfilling professional commitments, participating in research, and meeting social expectations). Participants' attitudes reflected their recognition (or rejection) of specific purposes, the briefings' perceived effectiveness in serving these purposes, and the briefings' perceived alignment (or conflict) with other priorities. Our findings illustrate the intrinsically rhetorical and variable nature of change.

  13. Mean Field Games Models-A Brief Survey

    KAUST Repository

    Gomes, Diogo A.

    2013-11-20

    The mean-field framework was developed to study systems with an infinite number of rational agents in competition, which arise naturally in many applications. The systematic study of these problems was started, in the mathematical community by Lasry and Lions, and independently around the same time in the engineering community by P. Caines, Minyi Huang, and Roland Malhamé. Since these seminal contributions, the research in mean-field games has grown exponentially, and in this paper we present a brief survey of mean-field models as well as recent results and techniques. In the first part of this paper, we study reduced mean-field games, that is, mean-field games, which are written as a system of a Hamilton-Jacobi equation and a transport or Fokker-Planck equation. We start by the derivation of the models and by describing some of the existence results available in the literature. Then we discuss the uniqueness of a solution and propose a definition of relaxed solution for mean-field games that allows to establish uniqueness under minimal regularity hypothesis. A special class of mean-field games that we discuss in some detail is equivalent to the Euler-Lagrange equation of suitable functionals. We present in detail various additional examples, including extensions to population dynamics models. This section ends with a brief overview of the random variables point of view as well as some applications to extended mean-field games models. These extended models arise in problems where the costs incurred by the agents depend not only on the distribution of the other agents, but also on their actions. The second part of the paper concerns mean-field games in master form. These mean-field games can be modeled as a partial differential equation in an infinite dimensional space. We discuss both deterministic models as well as problems where the agents are correlated. We end the paper with a mean-field model for price impact. © 2013 Springer Science+Business Media New York.

  14. Brief guided imagery and body scanning interventions reduce food cravings.

    Science.gov (United States)

    Hamilton, Jonathan; Fawson, Sophie; May, Jon; Andrade, Jackie; Kavanagh, David J

    2013-12-01

    Elaborated Intrusion (EI) Theory proposes that cravings occur when involuntary thoughts about food are elaborated; a key part of elaboration is affectively-charged imagery. Craving can be weakened by working memory tasks that block imagery. EI Theory predicts that cravings should also be reduced by preventing involuntary thoughts being elaborated in the first place. Research has found that imagery techniques such as body scanning and guided imagery can reduce the occurrence of food thoughts. This study tested the prediction that these techniques also reduce craving. We asked participants to abstain from food overnight, and then to carry out 10 min of body scanning, guided imagery, or a control mind wandering task. They rated their craving at 10 points during the task on a single item measure, and before and after the task using the Craving Experience Questionnaire. While craving rose during the task for the mind wandering group, neither the guided imagery nor body scanning group showed an increase. These effects were not detected by the CEQ, suggesting that they are only present during the competing task. As they require no devices or materials and are unobtrusive, brief guided imagery strategies might form useful components of weight loss programmes that attempt to address cravings.

  15. Skin and Liquid Crystal: A brief review on their similarities

    Directory of Open Access Journals (Sweden)

    Hamdan Suhaimi

    2016-08-01

    Full Text Available Looking oneself directly into a mirror and what does one see? The answer is of course one’s face. Taking good care of ones skin is synonymous to beauty and healthy life style. However, beauty last only as thick as a skin layer so the saying goes. While, liquid crystal, as the name implies, it looks like a crystal but flow like a liquid. Thus, how doesthis stucture called liquid crystal relate to skin and beauty? As most of us are aware skin and liquid crystalall around us, be it naturally or in technological applications. Our body body are covered with skin and liquid crystals. Surprise as it may seem but that is a fact, albeit peculiar to some. Classic example of natural liquid crystals are protein and cell membranes, while in industrial application such as electronic devices,for instance, screen of our laptop, digital watches and latest application in cosmeceuticals that isliquid crystal crystal emulsion. The question now arise is how does skin relate to liquid crystal? Why is it that this structure is crucial to the structure and function of skin? How does it relate to the delivery system of active ingredients which is important in many cosmeceuticals product? This paper will provide a brief review on the relationship of these two entities and present some work done in this area of interest. A model for the lipids of the top most layer of the skin namely stratum corneum will be highlighted.

  16. Performance Parameters and Characterizations of Nanocrystals: A Brief Review

    Directory of Open Access Journals (Sweden)

    Manasi M. Chogale

    2016-08-01

    Full Text Available Poor bioavailability of drugs associated with their poor solubility limits the clinical effectiveness of almost 40% of the newly discovered drug moieties. Low solubility, coupled with a high log p value, high melting point and high dose necessitates exploration of alternative formulation strategies for such drugs. One such novel approach is formulation of the drugs as “Nanocrystals”. Nanocrystals are primarily comprised of drug and surfactants/stabilizers and are manufactured by “top-down” or “bottom-up” methods. Nanocrystals aid the clinical efficacy of drugs by various means such as enhancement of bioavailability, lowering of dose requirement, and facilitating sustained release of the drug. This effect is dependent on the various characteristics of nanocrystals (particle size, saturation solubility, dissolution velocity, which have an impact on the improved performance of the nanocrystals. Various sophisticated techniques have been developed to evaluate these characteristics. This article describes in detail the various characterization techniques along with a brief review of the significance of the various parameters on the performance of nanocrystals.

  17. STS-121: Discovery L-1 Countdown Status Briefing

    Science.gov (United States)

    2006-01-01

    Bruce Buckingham, NASA Public Affairs, introduces Jeff Spaulding, NASA Test Director; Debbie Hahn, STS-121 Payload Manager; and Kathy Winters, Shuttle Weather Officer. Spaulding gives his opening statement on this one day prior to the launching of the Space Shuttle Discovery. He discusses the following topics: 1) Launch of the Space Shuttle Discovery; 2) Weather; 3) Load over of onboard reactants; 4) Hold time for liquid hydrogen; 5) Stowage of Mid-deck completion; 6) Check-out of onboard and ground network systems; 7) Launch windows; 8) Mission duration; 9) Extravehicular (EVA) plans; 10) Space Shuttle landing day; and 11) Scrub turn-around plans. Hahn presents and discusses a short video of the STS-121 payload flow. Kathy Winters gives her weather forecast for launch. She then presents a slide presentation on the following weather conditions for the Space Shuttle Discovery: 1) STS-121 Tanking Forecast; 2) Launch Forecast; 3) SRB Recovery; 4) CONUS Launch; 5) TAL Launch; 6) 24 Hour Delay; 7) CONUS 24 Hour; 8) TAL 24 Hour; 9) 48 Hour Launch; 10) CONUS 48 Hour; and 11) TAL 48 Hour. The briefing ends with a question and answer period from the media.

  18. The Human Neonatal Gut Microbiome: A Brief Review

    Directory of Open Access Journals (Sweden)

    Emily C. Gritz

    2015-03-01

    Full Text Available The field of genomics has expanded into subspecialties such as metagenomics over the course of the last decade and a half. The development of massively parallel sequencing capabilities has allowed for increasingly detailed study of the genome of the human microbiome, the microbial super organ that resides symbiotically within the mucosal tissues and integumentary system of the human host. The gut microbiome, and particularly the study of its origins in neonates, have become subtopics of great interest within the field of genomics. This brief review seeks to summarize recent literature regarding the origins and establishment of the neonatal gut microbiome, beginning in utero, and how it is affected by neonatal nutritional status (breastfed versus formula fed and gestational age (term versus preterm. We also explore the role of dysbiosis, a perturbation within the fragile ecosystem of the microbiome, and its role in the origin of select pathologic states, specifically, obesity and necrotizing enterocolitis in preterm infants. We discuss the evidence supporting enteral pre- and probiotic supplementation of commensal organisms such as Bifidobacterium and Lactobacillus in the neonatal period, and their role in the prevention and amelioration of necrotizing enterocolitis in premature infants. Finally, we review directions to consider for further research to promote human health within this field.

  19. Wnt/Ca2+ signaling pathway: a brief overview

    Institute of Scientific and Technical Information of China (English)

    Antara De

    2011-01-01

    The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical counterpart,the Wnt/β-catenin pathway.The non-canonical Wnt signaling pathways are diverse,defined as planer cell polarity pathway,Wnt-RAP1 signaling pathway,Wnt-Ror2 signaling pathway,Wnt-PKA pathway,Wnt-GSK3MT pathway,Wnt-aPKC pathway,Wnt-RYK pathway,Wnt-mTOR pathway,and Wnt/calcium signaling pathway.All these pathways exhibit a considerable degree of overlap between them.The Wnt/Ca2+ signaling pathway was deciphered as a crucial mediator in development.However,now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena.Many aspects of Wnt/Ca2+ pathway are yet enigmatic.This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca2+ signaling pathway.

  20. Biomarkers in the management of ulcerative colitis: a brief review

    Directory of Open Access Journals (Sweden)

    Hussain, Shabnum

    2011-01-01

    Full Text Available Several attempts have been made in the last two decades to investigate ulcerative colitis (UC patients during the natural course of the disease so as to identify appropriate surrogate markers of disease activity. Most patients with quiescent inflammatory bowel disease have low grade inflammation and it is possible that relapse occurs only once the inflammatory process crosses a critical intensity. Since inflammation is a continuous process, its direct assessment may provide us a quantitative pre-symptomatic measure of imminent relapse. If substantial, it may allow targeted treatment early, to avert relapse or formulate newer therapeutic strategies to maintain symptomatic remission. It is clinically very important to identify these patients at a subclinical stage, noninvasively, by various biomarkers. Biomarkers help to gain an objective measurement of disease activity as symptoms are often subjective. Biomarkers also help to avoid invasive procedures which are often a burden to the patient and the health care system. If an ideal biomarker existed for UC, it would greatly facilitate the work of the gastroenterologist treating these patients. Both “classical” and “emerging” biomarkers of relevance for UC have been studied, but the quest for an ideal biomarker still continues. In this brief review we describe various biomarkers of clinical importance.

  1. Tissue engineering in periodontal regeneration: A brief review

    Directory of Open Access Journals (Sweden)

    Sarita Dabra

    2012-01-01

    Full Text Available Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today′s medicine. Regeneration of periodontal tissue is perhaps one of the most complex process to occur in the body. Langer and colleagues proposed tissue engineering as a possible technique for regenerating the lost periodontal tissues. Tissue engineering is a multidisciplinary field, which involves the application of the principles and methods of engineering and life sciences to help in the development of biological substitutes to restore, maintain or improve the function of damaged tissues and organs. A Google/Medline search was conducted and relevant literature evaluating the potential role of the tissue engineering in periodontal regeneration, which included histological studies and controlled clinical trials, was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal regeneration were included. The available literature was analyzed and compiled. The analysis indicate tissue engineering to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. The purpose behind writing this brief review has been to integrate the evidence of research related to tissue engineering so as to implement them in our daily practice.

  2. Tissue engineering in periodontal regeneration: A brief review.

    Science.gov (United States)

    Dabra, Sarita; Chhina, Kamalpreet; Soni, Nitin; Bhatnagar, Rakhi

    2012-11-01

    Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today's medicine. Regeneration of periodontal tissue is perhaps one of the most complex process to occur in the body. Langer and colleagues proposed tissue engineering as a possible technique for regenerating the lost periodontal tissues. Tissue engineering is a multidisciplinary field, which involves the application of the principles and methods of engineering and life sciences to help in the development of biological substitutes to restore, maintain or improve the function of damaged tissues and organs. A Google/Medline search was conducted and relevant literature evaluating the potential role of the tissue engineering in periodontal regeneration, which included histological studies and controlled clinical trials, was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal regeneration were included. The available literature was analyzed and compiled. The analysis indicate tissue engineering to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. The purpose behind writing this brief review has been to integrate the evidence of research related to tissue engineering so as to implement them in our daily practice.

  3. FISHING IN SINALOA: BRIEF HISTORY AND SEARCH OF EPISTEME

    Directory of Open Access Journals (Sweden)

    Ramón Enrique Morán-Angulo

    2015-01-01

    Full Text Available This paper reports from bibliographic woven into three sections: a brief history of the prehispanic fishing, where the encounter between the indigenous communities of the State of Sinaloa and species that supported the incursion of primitive society in the various ecosystems are described water that make up the vast and varied territory of Sinaloa, where fishing is born as a function of interaction between society and nature through a deep empirical knowledge and a handmade primitive instrumentality that positions in the ecosystem within the flows of matter and energy. The importance of the species used for food fishing, religious symbolism and knowledge acquired and transmitted is denoted by the fishing process. In the second section the economic and social importance of fishing is contextualized, highlighting the current situation based on official information from the volumes recorded catch, species of economic importance and an account of the public policy process becomes mandataron fisheries, identifying transcendent moments on the national fisheries police and the current problem by going through today. Finally the episteme that addresses human resources training and scientific research supporting the fishing process Sinaloa taking the experience in developing the curriculum innovation plan of the Faculty of Marine Science in 2007 is discussed.

  4. Development of polymeric functionally graded scaffolds: a brief review.

    Science.gov (United States)

    Scaffaro, Roberto; Lopresti, Francesco; Maio, Andrea; Sutera, Fiorenza; Botta, Luigi

    2016-12-16

    Over recent years, there has been a growing interest in multilayer scaffolds fabrication approaches. In fact, functionally graded scaffolds (FGSs) provide biological and mechanical functions potentially similar to those of native tissues. Based on the final application of the scaffold, there are different properties (physical, mechanical, biochemical, etc.) which need to gradually change in space. Therefore, a number of different technologies have been investigated, and often combined, to customize each region of the scaffolds as much as possible, aiming at achieving the best regenerative performance.In general, FGSs can be categorized as bilayered or multilayered, depending on the number of layers in the whole structure. In other cases, scaffolds are characterized by a continuous gradient of 1 or more specific properties that cannot be related to the presence of clearly distinguished layers. Since each traditional approach presents peculiar advantages and disadvantages, FGSs are good candidates to overcome the limitations of current treatment options. In contrast to the reviews reported in the literature, which usually focus on the application of FGS, this brief review provides an overview of the most common strategies adopted to prepare FGS.

  5. Parental involvement in brief interventions for adolescent marijuana use.

    Science.gov (United States)

    Piehler, Timothy F; Winters, Ken C

    2015-09-01

    Adolescents (aged 12-18 years) identified in a school setting as abusing marijuana and other drugs were randomly assigned to complete 1 of 2 brief interventions (BIs). Adolescents and their parent (N = 259) were randomly assigned to receive either a 2-session adolescent only (BI-A) or a 2-session adolescent and additional parent session (BI-AP). Interventions were manualized and delivered in a school setting by trained counselors. Adolescents were assessed at intake and at 6 months following the completion of the intervention. Using a latent construct representing 6-month marijuana use outcomes, current findings supported previous research that BI-AP resulted in superior outcomes when compared to BI-A. The presence of a marijuana dependence diagnosis at baseline predicted poorer outcomes when compared to youth without a diagnosis. Both baseline diagnostic status and co-occurring conduct problems interacted with intervention condition in predicting marijuana use outcomes. A marijuana dependence diagnosis resulted in poorer marijuana use outcomes within the BI-A condition when compared to BI-AP. Co-occurring conduct problems were associated with poorer marijuana use outcomes within the BI-AP intervention when compared to BI-A. Implications for implementing BIs given diagnostic status, parent involvement, and co-occurring conduct problems are discussed.

  6. A brief simulation intervention increasing basic science and clinical knowledge

    Directory of Open Access Journals (Sweden)

    Maria L. Sheakley

    2016-04-01

    Full Text Available Background: The United States Medical Licensing Examination (USMLE is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose: To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods: This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (n l=515 and the intervention group received lecture plus a simulation exercise (nl+s=1,066. Assessment included summative exam questions (n=4 that were scored as pass/fail (≥75%. USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results: Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003. Discussion: Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum.

  7. A brief simulation intervention increasing basic science and clinical knowledge

    Science.gov (United States)

    Sheakley, Maria L.; Gilbert, Gregory E.; Leighton, Kim; Hall, Maureen; Callender, Diana; Pederson, David

    2016-01-01

    Background The United States Medical Licensing Examination (USMLE) is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (nl=515) and the intervention group received lecture plus a simulation exercise (nl+s=1,066). Assessment included summative exam questions (n=4) that were scored as pass/fail (≥75%). USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003). Discussion Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum. PMID:27060102

  8. Recent trends in internal medicine education: a brief update.

    Science.gov (United States)

    Flannery, Michael T

    2014-03-01

    This perspective attempts to bring graduate medical offices, residency programs and medical students interested in categorical internal medicine (CIM) a brief update on the American Board of Internal Medicine (ABIM), Accreditation Council for Graduate Medical Education (ACGME) and the National Registry for Medical Programs (NRMP) changes for the past 3-5 years in the United States (US). The US model for certification and recertification may serve as a homogenous example for other countries. This model will be described so that there is an understanding of the importance of such changes in the American system and its effect on resident education. This is critical knowledge for both teachers and learners in internal medicine in preparation for a lifetime career and requirements for certification/credentialing for both programs and their residents/fellows. Data from the review indicate a small increase in the number of applicants but a concordant decrease in ABIM initial certification exams. Programs should well be aware of the new focus on outcomes via the Next Accreditation System (NAS) being put forth by the ACGME.

  9. Biological restoration in pediatric dentistry: a brief insight.

    Science.gov (United States)

    Md, Indira; Singh Dhull, Kanika; Nandlal, B; Kumar Ps, Praveen; Singh Dhull, Rachita

    2014-01-01

    Dental caries is the most prevalent disease in humans, especially during early childhood. The restoration of such an extensive carious lesion should be done properly to reestablish their anatomy and hence their masticatory, phonetic, esthetic and space-maintainer functions in the dental arches. The consequences of premature loss of primary teeth are well known, namely the loss of vertical dimension of occlusion, tongue thrusting and mouth breathing habits, which can be the sources of future malocclusion. Satisfactory restoration of these teeth, improving esthetics, along with the management of space and function has always been a challenge for pediatric dentist. An ever increasing demand for esthetics has led to innovation and development of newer treatment modalities for these problems. In an attempt to widen the treatment options as biologically and conservatively as possible, tooth structure is used as a restorative material to rehabilitate severely destroyed tooth crowns. This technique consists of bonding sterile dental fragments, obtained either from the patient or from a tooth bank, to the teeth. Such a technique was termed as 'biological restoration'. This article aims at reviewing the evolution, techniques and outcome of such biological restorations. How to cite this article: MD Indira, Dhull KS, Nandlal B, Kumar PSP, Dhull RS. Biological Restoration in Pediatric Dentistry: A Brief Insight. Int J Clin Pediatr Dent 2014;7(3):197-201.

  10. Briefing book on the energy situation in New England

    Energy Technology Data Exchange (ETDEWEB)

    Brainard, J P; Munson, J S; Palmedo, P F

    1976-10-01

    This briefing book is designed to give a concise overview of the facts of the energy situation in New England and of attitudes within the region towards current energy issues. Many of the central problems of U.S. energy policy are manifested in the region in a magnified form. The region entered the period of energy shortages and increasing prices in an economically declining condition. Energy prices were already high in 1970, 30% higher than the rest of the country; the difference increased to 38% by 1974. With essentially no indigenous energy resources, New England is an energy-importing region. For various reasons it is also more dependent on petroleum than other regions of the country and, at the same time, distant from domestic petroleum-producing regions. The result is that over 60% of the fuels it consumes is imported from abroad. Although the future supply of energy to the region is critically dependent on energy-resource policies, policies related for example to coal and oil shale development, the region's concerns cluster around policies and technologies that are perceived to have a more direct impact on its energy welfare. Thus, energy conservation, solar energy, nuclear power, offshore oil development and, in general, the price of energy to the region are paramount issues of concern and debate. Following the Introductory chapter, these issues are discussed in four additional chapters: The Energy Situation in New England; Regional Energy Issues; Energy-Related Institutions; and State Legislation.

  11. Schizotypal Personality Questionnaire-Brief Revised: psychometric replication and extension.

    Science.gov (United States)

    Callaway, Dallas A; Cohen, Alex S; Matthews, Russell A; Dinzeo, Thomas

    2014-01-01

    The psychometric screening and detection of schizotypy through the use of concise self-report assessment instruments such as the Schizotypal Personality Questionnaire-Brief Revised (SPQ-BR; Cohen, Matthews, Najolia, & Brown, 2010) enables an expeditious identification of individuals at putatively elevated risk to develop schizophrenia-spectrum disorders. Using 2 large, culturally diverse, independent samples, this study expanded the psychometric evaluation of this instrument by presenting a series of confirmatory factor analyses; reviewing internal consistency reliabilities; and evaluating the construct validity of the scale by way of examining group differences in SPQ-BR scores between individuals with and without self-reported family histories of schizophrenia. The results indicate a 2-tier factor solution of the measure and indicate strong internal reliability for the scale. Findings regarding construct validity of the SPQ-BR are more variable with the Cognitive-Perceptual Deficits superordinate factor receiving the strongest evidentiary support. Limitations of this study and directions for future research are discussed.

  12. South Dakota State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The South Dakota State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in South Dakota. The profile is the result of a survey of NRC licensees in South Dakota. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in South Dakota.

  13. Brief Group Psychotherpay for Women after Divorce: Planning a Focused Experience.

    Science.gov (United States)

    Coche, Judith; Goldman, Janice

    1979-01-01

    A model for a brief, focused group psychotherapy experience for women, led by women therapists, is suggested as an effective means to ease the transition from marriage and to allow a redefinition of the self as a single individual. (Author)

  14. [Bison briefing paper for DOI bison meeting on the Fort Niobrara herd

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Briefing paper on the Fort Niobrara National Wildlife Refuge bison herd, presented at the Department of the Interior Bison Meeting, held in Billings, Montana, March...

  15. Massachusetts State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-03-12

    The Massachusetts State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Massachusetts. The profile is the result of a survey of NRC licensees in Massachusetts. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Massachusetts.

  16. Kentucky State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Kentucky State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Kentucky. The profile is the result of a survey of NRC licensees in Kentucky. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Kentucky.

  17. Oregon State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The Oregon State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Oregon. The profile is a result of a survey of NRC licensees in Oregon. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Oregon.

  18. Measuring Coping Behavior in Liver Transplant Candidates: A Psychometric Analysis of the Brief COPE.

    Science.gov (United States)

    Amoyal, Nicole; Fernandez, Anne C; Ng, Reuben; Fehon, Dwain C

    2016-09-01

    Liver transplant candidates must cope with significant physiological and psychological challenges. The Brief COPE is a frequently used measure of coping behavior; however, knowledge of the scale's factor structure and construct validity is limited with regard to liver transplant candidates. This study assessed the validity of the Brief COPE in 120 liver transplant candidates using exploratory factor analysis. Results revealed a 6-factor solution, only 2 of which were consistent with the original scale assignments. Construct validity of the 6 Brief COPE scales yielded in this study was demonstrated. The results indicate that the Brief COPE is valid, reliable, and can be meaningfully interpreted in liver transplant patients. Future research should confirm this factor structure and examine its predictive validity prior to widespread use among liver transplant patients. Suggestions are presented for enhancing the care of transplant candidates by promoting the use of adaptive coping mechanisms to manage distress.

  19. Physical and Chemical Sciences Center - research briefs. Volume 1-96

    Energy Technology Data Exchange (ETDEWEB)

    Mattern, P.L.

    1994-12-31

    This report provides brief summaries of research performed in chemical and physical sciences at Sandia National Laboratories. Programs are described in the areas of advanced materials and technology, applied physics and chemistry, lasers, optics, and vision, and resources and capabilities.

  20. Tennessee State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Tennessee State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Tennessee. The profile is the result of a survey of NRC licensees in Tennessee. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Tennessee.

  1. New Jersey State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The New Jersey state Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in New Jersey. The profile is the result of a survey of NRC licensees in New Jersey. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in New Jersey.

  2. Examination of relative reinforcement effects of stimuli identified through pretreatment and daily brief preference assessments.

    Science.gov (United States)

    DeLeon, I G; Fisher, W W; Rodriguez-Catter, V; Maglieri, K; Herman, K; Marhefka, J M

    2001-01-01

    Several brief preference assessments have recently been developed to identify reinforcers for individuals with developmental disabilities. One purported advantage of brief assessments is that they can be administered frequently, thus accommodating shifts in preference and presumably enhancing reinforcement effects. In this study, we initially conducted lengthy paired-choice preference assessments and identified a hierarchy of preferred items for 5 individuals with developmental disabilities. Subsequently, brief multiple-stimulus-without-replacement assessments using the same items were completed each day prior to work sessions. On days when results of the daily brief assessment differed from the one-time lengthy assessment, the relative reinforcing effects of the top items from each assessment were compared in a concurrent-schedule arrangement. The results revealed that when the two assessments differed, participants generally allocated more responses to the task associated with the daily top-ranked item.

  3. South Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The South Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in South Carolina. The profile is the result of a survey of NRC licensees in South Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as definied by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in South Carolina.

  4. Maine State Briefing Book on low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Maine State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Maine. The profile is the result of a survey of radioactive material licensees in Maine. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested partices including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant goverment agencies and activities, all of which may impact management practices in Maine.

  5. Florida State Briefing Book for low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-06-01

    The Florida State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Florida. The profile is the result of a survey of NRC licensees in Florida. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Florida.

  6. Rhode Island State Briefing Book on low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Rhode Island State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Rhode Island. The profile is the result of a survey of radioactive material licensees in Rhode Island. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Rhode Island.

  7. Connecticut State Briefing Book for low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-06-01

    The Connecticut State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Connecticut. The profile is the result of a survey of Nuclear Regulatory Commission licensees in Connecticut. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Connecticut.

  8. Wisconsin State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    The Wisconsin State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Wisconsin. The profile is the result of a survey of NRC licensees in Wisconsin. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Wisconsin.

  9. North Dakota State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-10-01

    The North Dakota State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in North Dakota. The profile is the result of a survey of NRC licensees in North Dakota. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in North Dakota.

  10. Utah State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Utah State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Utah. The profile is the result of a survey of NRC licensees in Utah. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Utah.

  11. A Brief Comparison of Chinese and Western Thinking Patterns:Synthesis, Analysis, and Antithesis

    Institute of Scientific and Technical Information of China (English)

    谭笑

    2013-01-01

    A brief comparison of Chinese and Western thinking patterns reflects in synthesis and analysis, which including tortuous thinking pattern and straightforward thinking pattern. These two different thinking patterns influence our social life everywhere.

  12. Ohio State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Ohio State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Ohio. The profile is the result of a survey of NRC licensees in Ohio. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Ohio.

  13. North Carolina State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The North Carolina State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in North Carolina. The profile is the result of a survey of NRC licensees in North Carolina. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in North Carolina.

  14. Wyoming State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Wyoming State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Wyoming. The profile is the result of a survey of NRC licensees in Wyoming. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Wyoming.

  15. Mississippi State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-08-01

    The Mississippi State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state an federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Mississippi. The profile is the result of a survey of NRC licensees in Mississippi. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Mississippi.

  16. Washington State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The Washington State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Washington. The profile is the result of a survey of NRC licensees in Washington. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Washington.

  17. Texas State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Texas State Briefing Book is one of a series of state briefing books on low-level radioactivee waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Texas. The profile is the result of a survey of NRC licensees in Texas. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Texas.

  18. Screening and brief intervention targeting risky drinkers in Danish general practice - a pragmatic controlled trial

    DEFF Research Database (Denmark)

    Beich, A.; Gannik, D.; Saelan, H.;

    2007-01-01

    AIMS: Recommendations for routine alcohol screening and brief counselling intervention in primary health care rest on results from intervention efficacy studies. By conducting a pragmatic controlled trial (PCT), we aimed at evaluating the effectiveness of the WHO recommendations for screening...

  19. 22 CFR 1423.28 - Briefs in support of exceptions; oppositions to exceptions; cross-exceptions.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL LABOR RELATIONS AUTHORITY UNFAIR LABOR PRACTICE PROCEEDINGS § 1423.28 Briefs in support of... following: (1) A concise statement of the case containing all that is material to the consideration of...

  20. Puerto Rico State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Puerto Rico State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Puerto Rico. The profile is the result of a survey of NRC licensees in Puerto Rico. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Puerto Rico.

  1. Brief description of research papers accepted for publication during 1979. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Nash, D.B

    1980-06-16

    Brief descriptions of research papers in radiobiology, biochemistry, metabolism, and biophysics published during 1979 are presented. The research was conducted by investigators in the Dept. of Radiation Biology and Biophysics. (ACR)

  2. Vermont State Briefing Book on low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Vermont State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Vermont. The profile is the result of a survey of Nuclear Regulatory Commission licensees in Vermont. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Vermont.

  3. Pennsylvania State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Pennsylvania State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Pennsylvania. The profile is the result of a survey of NRC licensees in Pennsylvania. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Pennsylvania.

  4. A Brief Study on the Approaches of the Task-Based English Language Teaching

    Institute of Scientific and Technical Information of China (English)

    刘定勇

    2012-01-01

    This paper makes a brief analysis on the approach of the Task-based English Language Teaching.Task based language teaching approach is a very useful method which is commonly used in English language learning classroom for second language learners.During the several English teaching in the experimental English class,the author states a brief analysis on the language acquisition approach applied in the students reading,writing,listening and speaking.

  5. Executive Functioning in Children with ASD: An Analysis of the BRIEF

    Science.gov (United States)

    Blijd-Hoogewys, E. M.; Bezemer, M. L.; van Geert, P. L.

    2014-01-01

    The Behavior Rating Inventory of Executive Functions (BRIEF) screens for executive function deficits in 5- to 18-year-olds. Data of three autism subgroups, according to DSM-IV-TR criteria (N = 35 Autistic Disorder, N = 27 Asperger's Disorder and N = 65 PDD-NOS), were analyzed. The total group has elevated scores on almost all BRIEF scales.…

  6. Longitudinal Data Collection in Career Pathways Programs: Core Indicators and Elements. Policy Brief

    Science.gov (United States)

    Chisman, Forrest; Murphy, Garrett; Parker, James; Spangenberg, Gail

    2010-01-01

    The goal of any career pathways programs is to provide low-skilled individuals with the education and training they need to move from their present level(s) of skills and abilities to the level(s) required to hold family-supporting jobs. While far from a definitive statement on the subject, this four-page Policy Brief offers a brief discussion and…

  7. A Brief Intervention to Reduce Suicide Risk in Military Service Members and Veterans

    Science.gov (United States)

    2014-12-01

    Fort Detrick, MD. Ghahramanlou-Holloway, M. (2014, April). Treatment needs of suicidal military personnel and family members. Invited...AD_________________ Award Number: W81XWH-09-2-0129 TITLE: A Brief Intervention to Reduce Suicide Risk in Military...3. DATES COVERED 25 Sep 2013 to 24 Sep 2014 4. TITLE AND SUBTITLE A Brief Intervention to Reduce Suicide Risk in Military 5a. CONTRACT NUMBER

  8. Digital soil mapping: A Brief History and Lessons

    Science.gov (United States)

    Minasny, Budiman; McBratney, Alex

    2014-05-01

    Digital soil mapping was formalised in a 2003 paper by McBratney et al. Since the term was introduced, there has been a huge increase on the research and papers in this topic. An IUSS working group was formed, and the GlobalSoilMap project was initiated. The research topic has become a successful formal discipline in soil science. Here we will have a brief look at the history of (digital) soil mapping and perhaps draw some lessons. The use of computer or numerical models to automatically map the soil is not new, its origin is difficult to pin-point. In 1925, before the age of digital computer and electronic sensors, Bernard Keen and William Haines conceived and built the first on-the-go soil strength sensor, made the measurements and made the first high-resolution digital soil map, and discovered the reality and importance of soil spatial variation. However this work was too far ahead of its time and was not taken up by contemporaries and is now largely forgotten. Since Jenny's (1941) factorial model was introduced, many have formulated topofunctions or climofunctions etc, however most of these works and empirical functions were not used for mapping, and were mostly exploratory data analysis. The idea of predicting soil across the landscapes with few equations seemed to be too radical. Work in the 1970s started to look at using remote sensing and infrared spectroscopy to map soil properties. The Laboratory for Applications of Remote Sensing in Purdue, proposed 'Spectral Mapping of Soil Organic Matter' using soil reflectance from the visible and near infrared signal of an airborne scanner. The lab. was very active and has produced lots of innovative research in the field of remote sensing, generating the first soil spectral library, predicting soil carbon from NIR, mapping soil carbon digitally. However maybe they too were ahead of their time, it took another 30 years before the resurgence of the soil spectroscopy work in the 2000s. It is an enormously active area

  9. NASA Tech Briefs, April 2002. Volume 26, No. 4

    Science.gov (United States)

    2002-01-01

    The contents include: 1) Application Briefs; 2) Sneak Preview of Sensors Expo; 3) The Complexity of the Diagnosis Problem; 4) Design Concepts for the ISS TransHab Module; 5) Characteristics of Supercritical Transitional Mixing Layers; 6) Electrometer for Triboelectric Evaluation of Materials; 7) Infrared CO2 Sensor With Built-In Calibration Chambers; 8) Solid-State Potentiometric CO Sensor; 9) Planetary Rover Absolute Heading Detection Using a Sun Sensor; 10) Concept for Utilizing Full Areas of STJ Photodetector Arrays; 11) Development of Cognitive Sensors; 12) Enabling Higher-Voltage Operation of SOl CMOS Transistors; 13) Estimating Antenna-Pointing Errors From Beam Squints; 14) Advanced-Fatigue-Crack-Growth and Fracture- Mechanics Program; 15) Software for Sequencing Spacecraft Actions; 16) Program Distributes and Tracks Organizational Memoranda; 16) Flat Membrane Device for Dehumidification of Air; 17) Inverted Hindle Mount Reduces Sag of a Large, Precise Mirror; 18) Heart-Pump-Outlet/Cannula Coupling; 19) Externally Triggered Microcapsules Release Drugs In Situ; 20) Combinatorial Drug Design Augmented by Information Theory; 21) Multiple-Path-Length Optical Absorbance Cell; 22) Model of a Fluidized Bed Containing a Mixture of Particles; 23) Refractive Secondary Concentrators for Solar Thermal Systems; 24) Cold Flow Calorimeter; 25) Methodology for Tracking Hazards and Predicting Failures; 26) Estimating Heterodyne-Interferometer Polarization Leakage; 27) An Efficient Algorithm for Propagation of Temporal- Constraint Networks; 28) Software for Continuous Replanning During Execution; 29) Surface-Launched Explorers for Reconnaissance/Scouting; 30) Firmware for a Small Motion-Control Processor; 31) Gear Bearings and Gear-Bearing Transmissions; and 32) Linear Dynamometer With Variable Stroke and Frequency.

  10. The Off-Site Rule. CERCLA Information Brief

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, B.

    1994-03-01

    Under Section 121(d)(3) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended by the Superfund Amendments and Reauthorization Act (SARA) of 1986, wastes generated as a result of CERCLA remediation activities and transferred off-site must be managed at a facility operating in compliance with federal laws. EPA issued its Off-Site Policy (OSWER Directive No. 9834, 11), which gave guidance on complying with this particular requirement. Specifically, EPA requires off-site waste management facilities to fulfill EPA`s definition of acceptability and has established detailed procedures for issuing and reviewing unacceptability determinations. EPA proposed amending the National Contingency Plan (NCP) (40 CFR part 300) to include the requirements contained in the Off-Site Policy (53 FR 48218). On September 22, 1993 EPA published the Off-Site Rules [58 FR 49200], which became effective on October 22, 1993. The primary purpose of the Off-Site Rule is to clarify and codify CERCLA`s requirement to prevent wastes generated from remediation activities conducted under CERCLA from contributing to present or future environmental problems at off-site waste management facilities that receive them. Thus, the Off-Site Rule requires that CERCLA wastes only be sent to off-site facilities that meet EPA`s acceptability criteria. The final Off-Site Rule makes two major changes to the proposed Off-Site Rule: (1) only EPA, not an authorized State, can make determinations of the acceptability of off-site facilities that manage CERCLA wastes, and (2) the Off-Site eliminate the distinction between CERCLA wastes governed under pre-SARA and post-SARA agreements. The purpose of this information Brief is to highlight and clarify EPA`s final Off-Site and its implications on DOE remedial actions under CERCLA.

  11. A brief history of vaccines & vaccination in India.

    Science.gov (United States)

    Lahariya, Chandrakant

    2014-04-01

    The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace variolation by vaccination, setting up of a few vaccine institutes, cholera vaccine trial and the discovery of plague vaccine. The early twentieth century witnessed the challenges in expansion of smallpox vaccination, typhoid vaccine trial in Indian army personnel, and setting up of vaccine institutes in almost each of the then Indian States. In the post-independence period, the BCG vaccine laboratory and other national institutes were established; a number of private vaccine manufacturers came up, besides the continuation of smallpox eradication effort till the country became smallpox free in 1977. The Expanded Programme of Immunization (EPI) (1978) and then Universal Immunization Programme (UIP) (1985) were launched in India. The intervening events since UIP till India being declared non-endemic for poliomyelitis in 2012 have been described. Though the preventive efforts from diseases were practiced in India, the reluctance, opposition and a slow acceptance of vaccination have been the characteristic of vaccination history in the country. The operational challenges keep the coverage inequitable in the country. The lessons from the past events have been analysed and interpreted to guide immunization efforts.

  12. Interpreting null findings from trials of alcohol brief interventions.

    Science.gov (United States)

    Heather, Nick

    2014-01-01

    The effectiveness of alcohol brief intervention (ABI) has been established by a succession of meta-analyses but, because the effects of ABI are small, null findings from randomized controlled trials are often reported and can sometimes lead to skepticism regarding the benefits of ABI in routine practice. This article first explains why null findings are likely to occur under null hypothesis significance testing (NHST) due to the phenomenon known as "the dance of the p-values." A number of misconceptions about null findings are then described, using as an example the way in which the results of the primary care arm of a recent cluster-randomized trial of ABI in England (the SIPS project) have been misunderstood. These misinterpretations include the fallacy of "proving the null hypothesis" that lack of a significant difference between the means of sample groups can be taken as evidence of no difference between their population means, and the possible effects of this and related misunderstandings of the SIPS findings are examined. The mistaken inference that reductions in alcohol consumption seen in control groups from baseline to follow-up are evidence of real effects of control group procedures is then discussed and other possible reasons for such reductions, including regression to the mean, research participation effects, historical trends, and assessment reactivity, are described. From the standpoint of scientific progress, the chief problem about null findings under the conventional NHST approach is that it is not possible to distinguish "evidence of absence" from "absence of evidence." By contrast, under a Bayesian approach, such a distinction is possible and it is explained how this approach could classify ABIs in particular settings or among particular populations as either truly ineffective or as of unknown effectiveness, thus accelerating progress in the field of ABI research.

  13. Pharmaceuticals: pharmaceutical cost controls--2005. End of Year Issue Brief.

    Science.gov (United States)

    Seay, Melicia; Varma, Priya

    2005-12-31

    The enactment of the Omnibus Budget Reconciliation Act of 1990 (OBRA '90) gave states the option of offering pharmaceutical benefits within their Medicaid programs. But the law placed restrictions on states' flexibility to control what prescriptions they would cover and required the states to reimburse outpatient prescription drugs from manufacturers that signed rebate agreements with the U.S. Department of Health and Human Services. Forty-nine states--Arizona is excluded, based on its program structure--and the District of Columbia currently offer prescription drug coverage under the Medicaid Drug Rebate Program. During the past four years, states all over the country have been plagued with revenue shortfalls in their state Medicaid budgets. While the fiscal situation improved for most states in the 2004 legislative session, many states still face budget pressures in 2005. Compounding existing budget pressures are threats from the Bush Administration to shift increased costs of the Medicaid program on to the states. All things considered, the economic pressure of funding Medicaid is at the top of legislative agendas in 2005. As in previous years, states are attempting to reduce costs to their Medicaid programs by seeking savings in their pharmaceutical programs. Prescription drug costs are highly attributed as a contributing factor to the fiscal climate of state Medicaid programs. Currently, prescription drug spending outpaces that of every other category of health care and drug prices are rising faster than inflation. In response, states are instituting a variety of pharmaceutical cost control measures such as creating preferred drug lists (PDLs), negotiating supplemental rebates, forming bulk purchasing pools, promoting generic drug substitution and implementing price controls. As prescription drug cost containment tools have gained acceptance and momentum, they continue to be controversial. This issue brief explores the debate, history, methodology, utilization

  14. A Brief Review of the Biology of Anorexia Nervosa

    Directory of Open Access Journals (Sweden)

    Magnus Sjogren

    2015-12-01

    Full Text Available Background: The etiology of Anorexia Nervosa (AN is unknown. A stress model for AN and other Eating Disorders, has been proposed by Connan and depicts risk factors and precipitating events, including biological, but several steps in this have yet to be evidenced. In order to elucidate the biology of AN, some studies have investigated the blood biochemistry in AN in the acute state, when BMI (Body Mass Index is very low, and compared this to a recovered state. In this brief review, we present the results of a literature search on potential biomarkers of AN. Method: A literature search using PUBMED and the following search terms: “Anorexia Nervosa” and “biomarker” revealed 180 articles (8th of May 2015. Additional searches included the search terms “gene”, “genetic”, “epigenetic”, “appetite”, “hormone”, and a specific search on “biology” and “review”. Furthermore, articles of interest were retrieved from the reference lists of the identified articles of the first PUBMED search. Results: In general, there is a shortage of studies on biomarkers and the biology of AN, at least when you compare to similar fields of research in Affective disorders and Schizophrenia. The studies performed reveals that heritability is involved and that biological factors independent of BMI may play a role in the pathophysiology of AN. In the acute stage of AN, decreased levels of leptin and increases in ghreline and obestatin, hormones involved in the regulation of appetite, are often found. Conclusion: In view of the rather few studies done, the small number of patients included in the studies, and the lack of additional information relating to behavioral and phenotypic characteristics, the results must be interpreted with caution. Preliminary findings indicate that factors independent of BMI may be involved in the pathophysiology of AN. During acute stages of AN, when BMI is lover than 17, 5, abnormal levels of appetite regulating

  15. Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, W.J.; Rembert, J.C.; Bauman, R.P.; Greenfield, J.C. Jr.; Piantadosi, C.A. (Duke Univ., Durham (USA))

    1990-11-01

    Myocardial oxygenation may be altered markedly by changes in tissue blood flow. During brief ischemia and reperfusion produced by transient occlusion of the left anterior descending artery in 10 open-chest dogs, changes in the oxygenation of tissue hemoglobin (Hb) plus myoglobin (Mb) and the oxidation-reduction (redox) state of mitochondrial cytochrome aa3 were monitored continuously using near-infrared spectroscopy. The nondestructive optical technique indicated that coronary occlusion produced an abrupt drop in tissue oxygen stores (tHb02 + Mb02), tissue blood volume (tBV), and the oxidation level of cytochrome aa3. Changes in the cytochrome oxidation state were related inversely to transmural collateral blood flow within the ischemic region (r = 0.77) measured with radiolabeled microspheres. Furthermore, there was a direct relationship (r = 0.91) between collateral blood flow and the tissue level of desaturated Hb and Mb (tHb + Mb). Reperfusion after 2 min of ischemia led to a synchronous overshoot of baseline in coronary flow and tBV followed by supranormal increases in tHb + Mb02 and the oxidation level of cytochrome aa3. The tHb + Mb level increased transiently during reperfusion. This response correlated inversely with collateral flow during ischemia (r = 0.91). Accordingly, the time required to reach peak tHb + Mb levels was shortest in dogs with high collateral flows (r = 0.75). Thus collateral blood flow partially sustains myocardial oxygenation during coronary artery occlusion and influences tissue reoxygenation early during reperfusion.

  16. Masking of a brief probe by sinusoidal frequency modulation.

    Science.gov (United States)

    Edwards, B W; Viemeister, N F

    1997-02-01

    Contrary to level detection models, the thresholds for a brief-duration probe masked by a sinusoidal frequency modulation (FM) masker increases as the modulation index (beta) of FM increases [Zwicker, Acustica 31, 243-256 (1974)]. In this paper the reason for this phenomenon is investigated. In experiment 1, a 10-ms, 1-kHz probe was detected in the presence of an FM masker centered at 1 kHz and sinusoidally modulated at 16 Hz. Thresholds increased by over 15 dB with increasing beta, consistent with Zwicker's findings. In experiment 2, the instantaneous frequency changes of the masker used in experiment 1 were clipped and the resulting thresholds indicated that detection was determined primarily by the masker's total frequency excursion rather than by its instantaneous sweep rate. In experiment 3, the FM maskers from the first two experiments were passed through a roex filter centered at 1 kHz and the resulting envelope was used to amplitude modulate a 1-kHz tone, producing approximately the same effective envelope at 1 kHz as the FM maskers. Threshold functions for the amplitude modulated (AM) maskers were similar to those for their corresponding FM maskers. Thresholds increased by over 15 dB while the total energy of the AM masker decreased by over 10 dB, again contrary to standard level-detection models. The results from these experiments can be explained, at least qualitatively, by a model based on envelope shape discrimination: similarities between the envelopes of the masker alone and masker-plus-probe at the output of an auditory filter centered on the frequency of the probe are primarily responsible for the observed masking, particularly at large beta's.

  17. A brief history of vaccines & vaccination in India

    Directory of Open Access Journals (Sweden)

    Chandrakant Lahariya

    2014-01-01

    Full Text Available The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace variolation by vaccination, setting up of a few vaccine institutes, cholera vaccine trial and the discovery of plague vaccine. The early twentieth century witnessed the challenges in expansion of smallpox vaccination, typhoid vaccine trial in Indian army personnel, and setting up of vaccine institutes in almost each of the then Indian States. In the post-independence period, the BCG vaccine laboratory and other national institutes were established; a number of private vaccine manufacturers came up, besides the continuation of smallpox eradication effort till the country became smallpox free in 1977. The Expanded Programme of Immunization (EPI (1978 and then Universal Immunization Programme (UIP (1985 were launched in India. The intervening events since UIP till India being declared non-endemic for poliomyelitis in 2012 have been described. Though the preventive efforts from diseases were practiced in India, the reluctance, opposition and a slow acceptance of vaccination have been the characteristic of vaccination history in the country. The operational challenges keep the coverage inequitable in the country. The lessons from the past events have been analysed and interpreted to guide immunization efforts.

  18. Screening and brief intervention for unhealthy drug use: little or no efficacy

    Directory of Open Access Journals (Sweden)

    Richard eSaitz

    2014-09-01

    Full Text Available Unhealthy drug use ranges from use that risks health harms through severe drug use disorders. This narrative review addresses whether screening and brief intervention, efficacious for risky alcohol use, has efficacy for reducing other drug use and consequences. Brief intervention among those seeking help shows some promise. Screening tools have been validated though most are neither brief nor simple enough for use in general health settings. Several randomized trials have tested the efficacy of brief intervention for unhealthy drug use identified by screening in general health settings (i.e. in people not seeking help for their drug use. Substantial evidence now suggests efficacy is limited or non-existent. Reasons likely include a range of actual and perceived severity (or lack of severity, concomitant unhealthy alcohol use and comorbid mental health conditions, and the wide range of types of unhealthy drug use (e.g. from marijuana, to prescription drugs, to heroin. Although brief intervention may have some efficacy for unhealthy drug users seeking help, the model of screening and brief intervention that has effects in primary care settings on risky alcohol use may not be efficacious for other drug use.

  19. Alternative Therapies for Excoriation (Skin Picking) Disorder: A Brief Update.

    Science.gov (United States)

    Torales, Julio; Barrios, Iván; Villalba, Jorge

    2017-01-01

    Context • Excoriation (skin picking) disorder is characterized by the need or urge to pick, scratch, pinch, touch, rub, scrub, squeeze, bite, or dig the skin, and it can be a perplexing condition for the inexperienced physician. Treatments include pharmacotherapy, psychotherapy, and alternative therapies. Alternative therapies for excoriation disorder and other body-focused repetitive behaviors include yoga, aerobic exercise, acupuncture, biofeedback, hypnosis, and inositol and N-acetylcysteine, among others. Objective • This review article intended to review the current literature on the alternative therapies to provide a brief update on their benefits for the treatment of excoriation disorder for use in conjunction with psychotherapy and pharmacotherapy in the management of a challenging group of patients. Design • This review (focusing on literature published in the last 15 y, selected from a search of PubMed) critically considers the evidence for the use of alternative therapies in the treatment of excoriation disorder. Setting • This review was conducted at the National University of Asunción (San Lorenzo, Paraguay). Results • Results for yoga were as follows: This technique may influence the structure and functioning of the areas of emotional processing involved in the pathophysiology of excoriation disorder and other body-focused repetitive behaviors, such as trichotillomania. Although still limited, the current research team's use of yoga as a treatment has given useful results. Results for aerobic exercise were as follows: People suffering from excoriation disorder and other-body focused repetitive behaviors generally have a worsening of their behaviors in times of negative mood and anxiety. As exercise has qualities that allow individuals to improve their mood and reduce their anxiety, it is likely that it also can help reduce behaviors like hair pulling or scratching, and it should be considered to be an adjunctive therapy. Results for

  20. Cost estimation when time and resources are limited: the Brief DATCAP.

    Science.gov (United States)

    French, Michael T; Roebuck, M Christopher; McLellan, A Thomas

    2004-10-01

    The Drug Abuse Treatment Cost Analysis Program (DATCAP) was designed in the early 1990s as a research guide to collect and analyze financial data from addiction treatment programs. The addiction research community could clearly benefit from a version of the DATCAP that reduced the time and effort required for its administration without compromising the integrity of its cost estimates. This paper introduces the Brief DATCAP and presents some preliminary findings. Initial feedback from respondents suggests that the Brief DATCAP is understandable, and easier and quicker to complete than the DATCAP. More importantly, preliminary results indicate that cost estimates from the Brief DATCAP differ from those of the longer DATCAP by less than 2%. These results have important research and policy implications because a shorter yet reasonably accurate cost instrument will enhance the feasibility and precision of future economic evaluations of addiction interventions.