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Sample records for avastin gbm briefing

  1. GBM 489 Complete Class

    OpenAIRE

    admn

    2015-01-01

    GBM 489 Complete Class Check this A+ tutorial guideline at   http://www.assignmentcloud.com/GBM-489/GBM-489-Strategic-Topics-in-Global-Business-Management GBM 489 Strategic Topics in Global Business Management GBM 489 Week 1 DQ 1 GBM 489 Week 1 DQ 2 GBM 489 Week 1 DQ 3 GBM 489 Week 1 Individual Global Trends Paper GBM 489 Week 2 DQ 1 GBM 489 Week 2 DQ 2 GBM 489 Week 2 DQ 3 GBM 489 Week 2 Individual Business Plan Article Analysis GBM 489...

  2. GBM 489 Courses/sanptutorial

    OpenAIRE

    jockty

    2015-01-01

    GBM 489 Week 1 Assignment Global Trends Paper GBM 489 Week 1 DQs GBM 489 Week 2 Assignment Business Plan Article Analysis GBM 489 Week 2 DQs GBM 489 Week 2 Global Business Plan Market Research GBM 489 Week 3 DQs GBM 489 Week 3 Individual Assignments From the Readings GBM 489 Week 3 Assignment Global Business Plan Operations GBM 489 Week 4 DQs GBM 489 Week 4 Assignment Global Business Plan Financial GBM 489 Week 5 Assignment Global Business Plan Presenta...

  3. GBM 380 UOP TUTORIAL / Uoptutorial

    OpenAIRE

    kem

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     GBM 380 Week 1 Globalization Paper GBM 380 Week 1 DQs GBM 380 Week 2 Business Organizations Paper GBM 380 Week 2 Globalization Trends Paper GBM 380 Week 2 DQs GBM 380 Week 3 Concepts of Culture GBM 380 Week 3 DQs GBM 380 Week 4 International Business Strategies Case Study Analysis GBM 380 Week 4 Infrastructures and Natural Resources Paper GBM 380 Week 4 DQs GBM 380 Week 5...

  4. GBM 380 Uop Material-gbm380dotcom

    OpenAIRE

    CarterOlivia2

    2015-01-01

    For more course tutorials visit www.gbm380.com Tutorial Purchased: 5 Times; Rating: A     GBM 380 Week 1 Globalization Paper GBM 380 Week 1 DQs GBM 380 Week 2 Business Organizations Paper GBM 380 Week 2 Globalization Trends Paper GBM 380 Week 2 DQs GBM 380 Week 3 Concepts of Culture GBM 380 Week 3 DQs GBM 380 Week 4 International Business Strategies Case Study Analysis GBM 380 Week 4 Infrastructures and Natural Resources Paper ...

  5. GBM 489 UOP TUTORIAL / Uoptutorial

    OpenAIRE

    kem

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   GBM 489 Week 1 Assignment Global Trends Paper GBM 489 Week 1 DQs GBM 489 Week 2 Assignment Business Plan Article Analysis GBM 489 Week 2 DQs GBM 489 Week 2 Global Business Plan Market Research GBM 489 Week 3 DQs GBM 489 Week 3 Individual Assignments From the Readings GBM 489 Week 3 Assignment Global Business Plan Operations GBM 489 Week 4 DQs GBM 489 Week 4 Assignment Global Business Pl...

  6. GBM 489 Course tutorial/ indigohelp

    OpenAIRE

    ASVD

    2015-01-01

    For more classes visit www.indigohelp.com   GBM 489 Week 1 Assignment Global Trends Paper GBM 489 Week 1 DQs GBM 489 Week 2 Assignment Business Plan Article Analysis GBM 489 Week 2 DQs GBM 489 Week 2 Global Business Plan Market Research GBM 489 Week 3 DQs GBM 489 Week 3 Individual Assignments From the Readings GBM 489 Week 3 Assignment Global Business Plan Operations GBM 489 Week 4 DQs GBM 489 Week 4 Assignment Global Business Plan Financia...

  7. GBM 489 Uop Material-gbm489dotcom

    OpenAIRE

    CarterOlivia2

    2015-01-01

    For more course tutorials visit www.gbm489.com   GBM 489 Week 1 Assignment Global Trends Paper GBM 489 Week 1 DQ 1,DQ 2 and DQ 3 GBM 489 Week 2 Assignment Business Plan Article Analysis GBM 489 Week 2 DQ 1,DQ 2 and DQ 3 GBM 489 Week 2 Global Business Plan Market Research GBM 489 Week 3 DQ 1,DQ 2 and DQ 3 GBM 489 Week 3 Individual Assignments From the Readings GBM 489 Week 3 Assignment Global Business Plan Operations GBM 489 Week 4 DQ 1,DQ 2 and...

  8. GBM 489 UOP Course Tutorial / gbm489dotcom

    OpenAIRE

    MunnaNaidu4

    2015-01-01

    GBM 489 Entire Course (UOP) For more course tutorials visit www.gbm489.com   GBM 489 Week 1 Assignment Global Trends Paper GBM 489 Week 1 DQ 1,DQ 2 and DQ 3 GBM 489 Week 2 Assignment Business Plan Article Analysis GBM 489 Week 2 DQ 1,DQ 2 and DQ 3 GBM 489 Week 2 Global Business Plan Market Research GBM 489 Week 3 DQ 1,DQ 2 and DQ 3 GBM 489 Week 3 Individual Assignments From the Readings GBM 489 Week 3 Assignment Global Business Plan Operations ...

  9. GBM 381 UOP TUTORIAL / Uoptutorial

    OpenAIRE

    kem

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   GBM 381 Week 1 Individual Assignment Major Trade Theories Paper   GBM 381 Week 1 DQs   GBM 381 Week 2 Individual Assignment Product Life Cycle Paper   GBM 381 Week 2 Learning Team Assignment Trading Position Paper   GBM 381 Week 2 DQs   GBM 381 Week 3 Individual Assignment Assignments From the Text   GBM 381 Week 3 Learning Team Assignment Forei...

  10. GBM 381 Uop Material-gbm381dotcom

    OpenAIRE

    CarterOlivia2

    2015-01-01

     For more course tutorials visit www.gbm381.com   GBM 381 Week 1 Individual Assignment Major Trade Theories Paper GBM 381 Week 1 DQ 1 and DQ 2 GBM 381 Week 2 Individual Assignment Product Life Cycle Paper GBM 381 Week 2 Learning Team Assignment Trading Position Paper GBM 381 Week 2 DQ 1 and DQ 2 GBM 381 Week 3 Individual Assignment Assignments From the Text GBM 381 Week 3 Learning Team Assignment Foreign Exchange Market Paper GBM 381 Week 3 DQ...

  11. GBM 381 UOP Course Tutorial / gbm381dotcom

    OpenAIRE

    MunnaNaidu4

    2015-01-01

    GBM 381 Entire Course (UOP) For more course tutorials visit www.gbm381.com   GBM 381 Week 1 Individual Assignment Major Trade Theories Paper GBM 381 Week 1 DQ 1 and DQ 2 GBM 381 Week 2 Individual Assignment Product Life Cycle Paper GBM 381 Week 2 Learning Team Assignment Trading Position Paper GBM 381 Week 2 DQ 1 and DQ 2 GBM 381 Week 3 Individual Assignment Assignments From the Text GBM 381 Week 3 Learning Team Assignment Foreign Exchange Market P...

  12. GBM Spectral Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — For GBM, input is daily or trigger CSPEC or CTIME file from Fermi archive and corresponding response file from our archive. For LAT, input is daily spectrum file...

  13. GBM Accreting Pulsar Histories

    Data.gov (United States)

    National Aeronautics and Space Administration — For each source we plot the history of pulse frequency and pulsed flux measured using the Fermi Gamma-Ray Burst Monitor (GBM) NaI detectors. For these measurements...

  14. GLAST's GBM Burst Trigger

    Science.gov (United States)

    Band, D.; Briggs, M.; Connaughton, V.; Kippen, M.; Preece, R.

    2003-01-01

    The GLAST Burst Monitor (GBM) will detect and localize bursts for the GLAST mission, and provide the spectral and temporal context in the traditional 10 keV to 25 MeV band for the high energy observations by the Large Area Telescope (LAT). The GBM will use traditional rate triggers in up to three energy bands, and on a variety of timescales between 16 ms and 16 s.

  15. GBM 380 UOP course tutorial/tutorialoutlet

    OpenAIRE

    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   GBM 380 Week 1 Globalization Paper GBM 380 Week 1 DQs GBM 380 Week 2 Business Organizations Paper GBM 380 Week 2 Globalization Trends Paper GBM 380 Week 2 DQs GBM 380 Week 3 Concepts of Culture GBM 380 Week 3 Team Assignment Political and Legal Systems GBM 380 Week 3 DQs GBM 380 Week 4 International Business Strategies Case Study Analysis GBM 380 Week 4 Infrastructures and Natural Res...

  16. FERMIGTRIG - Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by one or more of the 14 GBM detectors (12 NaI and 2 BGO). Note that there are two Browse catalogs resulting from GBM...

  17. GBM Response Matrix FITS Files

    Data.gov (United States)

    National Aeronautics and Space Administration — Time-dependent detector response matrices for each GBM detector covering the duration of every GBM flare. Needed in the spectral analysis software to relate...

  18. GBM 489 UOP course tutorial/tutorialoutlet

    OpenAIRE

    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   GBM 489 Week 1 Assignment Global Trends Paper   GBM 489 Week 1 DQs   GBM 489 Week 2 Assignment Business Plan Article Analysis   GBM 489 Week 2 DQs   GBM 489 Week 2 Global Business Plan Market Research   GBM 489 Week 3 DQs   GBM 489 Week 3 Individual Assignments From the Readings   GBM 489 Week 3 Assignment Global Business Plan Ope...

  19. GBM 381 UOP course tutorial/tutorialoutlet

    OpenAIRE

    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     GBM 381 Week 1 Individual Assignment Major Trade Theories Paper   GBM 381 Week 1 DQs   GBM 381 Week 2 Individual Assignment Product Life Cycle Paper   GBM 381 Week 2 Learning Team Assignment Trading Position Paper   GBM 381 Week 2 DQs   GBM 381 Week 3 Individual Assignment Assignments From the Text   GBM 381 Week 3 Learning Team Ass...

  20. Intravitreal Bevacizumab (Avastin Injection for Neovascular Glaucoma

    Directory of Open Access Journals (Sweden)

    Shahin Yazdani

    2008-12-01

    Full Text Available

    PURPOSE: To report two cases with neovascular glaucoma secondary to ischemic central retinal vein occlusion (CRVO who were treated with intravitreal bevacizumab. CASE REPORT: Two patients were referred for neovascular glaucoma following CRVO. Visual acuity was light perception. Both eyes had extensive iris neovascularization (NVI, synechial angle closure and high intraocular pressure (IOP in spite of anti-glaucoma medications. After obtaining informed consent, both eye received an intravitreal injection of 2.5 mg (0.1 ml bevacizumab (Avastin. Both eyes demonstrated dramatic IOP reduction together with decreased severity and extent of NVI during 4 weeks of follow up. Visual acuity remained unchanged. CONCLUSION: Despite the dramatic short-term response in terms of IOP reduction and regression of neovascularization, due to limited clinical experience, one should consider this novel indication for bevacizumab cautiously.

  1. 77 FR 11554 - Final Decision on Withdrawal of Breast Cancer Indication for AVASTIN (Bevacizumab) Following...

    Science.gov (United States)

    2012-02-27

    ... HUMAN SERVICES Food and Drug Administration Final Decision on Withdrawal of Breast Cancer Indication for... final decision withdrawing approval of the breast cancer indication for AVASTIN (Bevacizumab). The... proposal to withdraw the approval. DATES: Withdrawal of AVASTIN's breast cancer indication was...

  2. Effect of Avastin on the migration and invasion of pterygium fibroblasts

    Institute of Scientific and Technical Information of China (English)

    Wei Liu; Xiangyin Sha; Ye Wen; Wenting Zhao; Wei Luo; Zanmei Hua

    2014-01-01

    Purpose:.To evaluate the effect of Avastin on human ptery-gium fibroblast migration and invasiveness. Methods:.VEGF secretion was compared between human pterygium fibroblasts and conjunctival fibroblasts by measur-ing VEGF-A by ELISA. The influence of Avastin on HPF mi-gration and invasiveness was observed by wound scratch and Transwell migration assays..The expression of p-ERK1/2 and p-FAK was analyzed by western blotting. Results: (1)VEGF was secreted in higher amounts by human pterygium fibroblasts than by conjunctival fibroblasts. (2) Avastin treatment decreased HPF migration and invasion. (3) Avastin significantly decreased the expression of p-ERK1/2 and p-FAK in human pterygium fibroblasts. Conclusion:.Avastin can inhibit migration and invasion of HPFs by decreasing the expression of p-ERK1/2 and p-FAK.

  3. FERMIGBRST - Fermi GBM Burst Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by a subset of the 14 GBM detectors (12 NaI and 2 BGO) which have been classified as gamma-ray bursts (GRBs). Note...

  4. Fermi GBM: Results from the First Year +

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2009-01-01

    Gamma-ray Burst Monitor (GBM) has performed well in the first year+. GBM triggers 353 Gamma-ray Bursts (GRBs), 168 SGR events, 18 TGFs, and 1 solar flare to date. Short GRBs appear contracted in time and shifted to higher energy than long GRBs. Pulsed persistent emission from SGR 1550-5418 detected. TGFs are shorter, have higher average photon energies, and much higher count rates than GRBs. GBM monitoring of accreting pulsars provides long-term spin-histories. GBM Earth occultation monitoring complements Swift.

  5. Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia

    OpenAIRE

    Dimitrios Brouzas; Chryssanthi Koutsandrea; Marilita Moschos; et al

    2009-01-01

    Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®), in a patient with exudative age-related macular degeneration (AMD).Patients and method: Case report.Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the pat...

  6. Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin®) for AMD followed by controlateral sympathetic ophthalmia

    OpenAIRE

    Brouzas, Dimitrios; Koutsandrea, Chryssanthi; Moschos, Marilita; Papadimitriou, Spiros; Ladas, Ioannis; Apostolopoulos, Michael

    2009-01-01

    Purpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®), in a patient with exudative age-related macular degeneration (AMD). Patients and method: Case report. Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with recon...

  7. Gamma-Ray Astrophysics NSSTC Fermi GBM

    Data.gov (United States)

    National Aeronautics and Space Administration — The Fermi Gamma-Ray Burst Monitor (GBM) is not a pointed or imaging instrument. To determine fluxes for known sources, we measure the change in the count rate...

  8. All Sky Observations with BATSE and GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2008-01-01

    The Burst and Transient Source Experiment (BATSE) on board the Compton Gamma Ray Observatory (CGRO) monitored the entire sky from 1991-2000. I will review highlights of BATSE observations including gamma ray bursts, black hole candidates, accreting pulsars, and active galaxies. On 2008 June 11, the Fermi Gamma Ray Space Telescope was launched. The Gamma ray Burst Monitor (GBM) on board Fermi continues the all-sky monitoring legacy started with BATSE. I will review early results and planned observations with GBM.

  9. Public voices in pharmaceutical deliberations: negotiating "clinical benefit" in the FDA's Avastin Hearing.

    Science.gov (United States)

    Teston, Christa B; Graham, S Scott; Baldwinson, Raquel; Li, Andria; Swift, Jessamyn

    2014-06-01

    This article offers a hybrid rhetorical-qualitative discourse analysis of the FDA's 2011 Avastin Hearing, which considered the revocation of the breast cancer indication for the popular cancer drug Avastin. We explore the multiplicity of stakeholders, the questions that motivated deliberations, and the kinds of evidence presented during the hearing. Pairing our findings with contemporary scholarship in rhetorical stasis theory, Mol's (2002) construct of multiple ontologies, and Callon, Lascoumes, and Barthe's (2011) "hybrid forums," we demonstrate that the FDA's deliberative procedures elides various sources of evidence and the potential multiplicity of definitions for "clinical benefit." Our findings suggest that while the FDA invited multiple stakeholders to offer testimony, there are ways that the FDA might have more meaningfully incorporated public voices in the deliberative process. We conclude with suggestions for how a true hybrid forum might be deployed. PMID:24682644

  10. Intravitreal bevacizumab (Avastin) treatment of diffuse diabetic macular edema in an Indian population

    OpenAIRE

    Kumar Atul; Sinha Subijay

    2007-01-01

    Background: To report the anatomic and visual acuity response after intravitreal bevacizumab (Avastin) in patients with diffuse diabetic macular edema. Design: Prospective, interventional case series study. Materials and Methods: This study included 20 eyes of metabolically stable diabetes mellitus with diffuse diabetic macular edema with a mean age of 59 years who were treated with two intravitreal injections of bevacizumab 1.25 mg in 0.05 ml six weeks apart. Main outcome measures were ...

  11. The US FDAs withdrawal of the breast cancer indication for Avastin (bevacizumab)

    OpenAIRE

    Sasich, Larry D.; Sukkari, Sana Rikabi

    2011-01-01

    On November 18, 2011, the US Food and Drug Administration (US FDA) announced that breast cancer indication for Avastin (bevacizumab) had been withdrawn after concluding that the drug has not been shown to be safe and effective for the treatment of breast cancer. The specific indication that was withdrawn was for the use of bevacizumab in metastatic breast cancer, with paclitaxel for the treatment of patients who have not received chemotherapy for metastatic HER2-negative breast cancer.

  12. Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat.

    Directory of Open Access Journals (Sweden)

    Yan-Yan Zhao

    Full Text Available The similarity between a proposed biosimilar product and the reference product can be affected by many factors. This study is designed to examine whether any subtle difference in the distribution of the charge variants of an Avastin biosimilar can affect its in vitro potency and in vivo PK. Here, the acidic, basic and main peak fractions of a biosimilar product were isolated using high-performance cation-exchange chromatography and were subjected to various studies to compare their in vitro properties and in vivo PK profile. A serial of analytical methods, including size exclusion chromatography (SEC, imaged capillary isoelectric focusing (icIEF capillary zone electrophoresis (CZE and cation-exchange chromatography (CEX-HPLC were also used to characterize the isolated charge variants. The kinetics constant was measured using a Biacore X100 system. The study indicates the biosimilar product has a high similarity with avastin in physicochemical properties. The potency in vitro and PK profile in rat of charge variants and biosimilar product are consistent with avastin.

  13. Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat.

    Science.gov (United States)

    Zhao, Yan-Yan; Wang, Ning; Liu, Wan-Hui; Tao, Wen-Jie; Liu, Li-Li; Shen, Zhen-Duo

    2016-01-01

    The similarity between a proposed biosimilar product and the reference product can be affected by many factors. This study is designed to examine whether any subtle difference in the distribution of the charge variants of an Avastin biosimilar can affect its in vitro potency and in vivo PK. Here, the acidic, basic and main peak fractions of a biosimilar product were isolated using high-performance cation-exchange chromatography and were subjected to various studies to compare their in vitro properties and in vivo PK profile. A serial of analytical methods, including size exclusion chromatography (SEC), imaged capillary isoelectric focusing (icIEF) capillary zone electrophoresis (CZE) and cation-exchange chromatography (CEX-HPLC) were also used to characterize the isolated charge variants. The kinetics constant was measured using a Biacore X100 system. The study indicates the biosimilar product has a high similarity with avastin in physicochemical properties. The potency in vitro and PK profile in rat of charge variants and biosimilar product are consistent with avastin. PMID:26987122

  14. Magnetar Observations with Fermi/GBM

    Science.gov (United States)

    Kouveliotou, Chryssa

    2009-01-01

    NASA's Fermi Observatory was launched June 11, 2009; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. In the first year of operations we recorded emission from four magnetar sources; of these, only one was an old magnetar: SGR 1806+20. The other three detections were: SGR J0501+4516, newly discovered with Swift and extensively monitored with both Swift and GBM, SGR J1550-5418, a source originally classified as an Anomalous X-ray Pulsar (AXP) and a very recently discovered new source, SGR 0418+5729. I report below on the current status of the analyses efforts of the GBM data.

  15. Fermi GBM Observations of Terrestrial Gamma Flashes

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Briggs, M. S.; Connaughton, V.; Fishman, G. J.; Bhat, P. N.; Paciesas, W. S.; Preece, R. D.; Kippen, R. M.; vonKienlin, A.; Dwyer, J. R.; Smith, D. M.; Holzworth, R.

    2010-01-01

    In its first two years of operation, the Fermi Gamma Ray Burst Monitor (GBM) has observed 79 Terrestrial Gamma Flashes (TGFs). The thick Bismuth Germanate (BGO) detectors are excellent for TGF spectroscopy, having a high probability of recording the full energy of an incident photon, spanning a broad energy range from 150 keV to 40 MeV, and recording a large number of photons per TGF. Correlations between GBM TGF triggers and lightning sferics detected with the World-Wide Lightning Location Network indicate that TGFs and lightning are simultaneous to within tens of microseconds.

  16. Three years of Transients with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2012-01-01

    The Gamma-ray Burst Monitor (GBM) is an all-sky monitoring instrument, sensitive between 8 keV and 40 MeV, with a primary objective of supporting the Large Area Telescope (LAT) in observations of Gamma-Ray Bursts (GRBs). Both instruments are part of the Fermi Gamma-ray Space Telescope. Together, the GBM and LAT instruments have provided ground-breaking measurements of GRBs that have, after 10 years of focus on GRB afterglows, inspired renewed interest in the prompt emission phase of GRBs and the physical mechanisms that fuel them. In addition to GRB science, GBM has made significant contributions to the astrophysics of galactic transient sources including long-term variations in the Crab nebula, spin state transitions in accretion powered pulsars, state transitions in black hole X-ray binaries, and unprecedented time-resolved spectral studies of soft gamma-ray repeater bursts. Closer to home, GBM also contributes to solar flare and terrestrial gamma flash science.

  17. TCGA Workshop: Genomics and Biology of Glioblastoma Multiforme (GBM) - TCGA

    Science.gov (United States)

    The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) held a workshop entitled, “Genomics and Biology of Glioblastoma Multiforme (GBM),” to review the initial GBM data from the TCGA pilot project.

  18. Diagnosis and classification of Goodpastures disease (anti-GBM)

    OpenAIRE

    Hellmark, Thomas; Segelmark, Mårten

    2014-01-01

    Goodpastures disease or anti-glomerular basement membrane disease (anti-GBM-disease) is included among immune complex small vessel vasculitides. The definition of anti-GBM disease is a vasculitis affecting glomerular capillaries, pulmonary capillaries, or both, with GBM deposition of anti-GBM auto-antibodies. The disease is a prototype of autoimmune disease, where the patients develop auto-antibodies that bind to the basement membranes and activate the classical pathway of the complement syst...

  19. Fermi/GBM Results of Magnetars

    Science.gov (United States)

    Kouveliotou, chryssa

    2011-01-01

    Magnetars are magnetically powered rotating neutron stars with extreme magnetic fields (over 10(exp 14) Gauss). They were discovered in the X- and gamma-rays where they predominantly emit their radiation. Very few sources (roughly 18) have been found since their discovery in 1987. NASA's Fermi Gamma-ray Space Telescope was launched June 11,2009; since then the Fermi Gamma-ray Burst Monitor (GBM) recorded emission from four magnetar sources. Two of these were brand new sources, SGR J0501 +4516, discovered with Swift and extensively monitored with Swift and GBM, SGR J0418+5729, discovered with GBM and the Interplanetary Network (IPN). A third was SGR Jl550-5418, a source originally classified as an Anomalous X-ray Pulsar (AXP IEI547.0-5408), but exhibiting a very prolific outburst with over 400 events recorded in January 2009. In my talk I will give a short history of magnetars and describe how this, once relatively esoteric field, has emerged as a link between several astrophysical areas including Gamma-Ray Bursts. Finally, I will describe the exciting new results of Fermi in this field and the current status of our knowledge of the magnetar population properties and magnetic fields.

  20. Massive choroidal hemorrhage after intravitreal administration of bevacizumab (Avastin® for AMD followed by controlateral sympathetic ophthalmia

    Directory of Open Access Journals (Sweden)

    Dimitrios Brouzas

    2009-08-01

    Full Text Available Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®, in a patient with exudative age-related macular degeneration (AMD.Patients and method: Case report.Results: Ten days after intravitreal injection of 1.25 mg Avastin®, the patient manifested acute loss of vision with excruciating pain. An extensive choroidal detachment was evident in close contact with the lens, which necessitated an emergency sclerotomy with reconstruction of the anterior chamber. Four months later, the eye proceeded to phthisis bulbi. Five months after the injection, the patient complained of mild pain, photophobia, and visual acuity deterioration from the fellow eye. The diagnosis of sympathetic ophthalmia was suggested and treated with intravitreal injections of triamcinolone acetonide every three months with good response, complicated by elevation of intraocular pressure which we managed with Ahmet valve implantation.Conclusion: Serious ocular complications after intravitreal of Avastin® can not be excluded, including massive choroidal hemorrhage and sympathetic ophthalmia of the fellow eye.Keywords: Avastin® complication, intravitreal injection, choroidal detachment, Phthisis bulbi, sympathetic ophthalmia

  1. Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines

    Science.gov (United States)

    Binder, Zev A.; Wilson, Kelli M.; Salmasi, Vafi; Orr, Brent A.; Eberhart, Charles G.; Siu, I-Mei; Lim, Michael; Weingart, Jon D.; Quinones-Hinojosa, Alfredo; Bettegowda, Chetan; Kassam, Amin B.; Olivi, Alessandro; Brem, Henry; Riggins, Gregory J.; Gallia, Gary L.

    2016-01-01

    Objective Human tumor cell lines form the basis of the majority of present day laboratory cancer research. These models are vital to studying the molecular biology of tumors and preclinical testing of new therapies. When compared to traditional adherent cell lines, suspension cell lines recapitulate the genetic profiles and histologic features of glioblastoma multiforme (GBM) with higher fidelity. Using a modified neural stem cell culture technique, here we report the characterization of GBM cell lines including GBM variants. Methods Tumor tissue samples were obtained intra-operatively and cultured in neural stem cell conditions containing growth factors. Tumor lines were characterized in vitro using differentiation assays followed by immunostaining for lineage-specific markers. In vivo tumor formation was assayed by orthotopic injection in nude mice. Genetic uniqueness was confirmed via short tandem repeat (STR) DNA profiling. Results Thirteen oncosphere lines derived from GBM and GBM variants, including a GBM with PNET features and a GBM with oligodendroglioma component, were established. All unique lines showed distinct genetic profiles by STR profiling. The lines assayed demonstrated a range of in vitro growth rates. Multipotency was confirmed using in vitro differentiation. Tumor formation demonstrated histologic features consistent with high grade gliomas, including invasion, necrosis, abnormal vascularization, and high mitotic rate. Xenografts derived from the GBM variants maintained histopathological features of the primary tumors. Conclusions We have generated and characterized GBM suspension lines derived from patients with GBMs and GBM variants. These oncosphere cell lines will expand the resources available for preclinical study. PMID:27028405

  2. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration in treatment-naive patients

    DEFF Research Database (Denmark)

    Pedersen, Karen Bjerg; Sjølie, Anne Katrin; Møller, Flemming

    2008-01-01

    Abstract. Purpose: To report the effects of intravitreal bevacizumab (Avastin((R))) in treatment-naive patients with exudative age-related macular degeneration (ARMD) assessed by visual acuity (VA), optical coherence tomography (OCT) and contrast sensitivity. Methods: A prospective, uncontrolled...... neovascularization (CNV), 6 (23.1%) had predominantly classic CNV and 5 (19.2%) had minimally classic CNV. Ophthalmic outcome measures included changes in standardized Early Treatment Diabetic Research Study (ETDRS) VA, contrast sensitivity and OCT. The patients were examined at baseline and 1 week, 6 weeks, 3...... months and 6 months after the first injection. Re-treatment was given on an 'as needed' basis. Results: Twenty-four eyes of 24 patients completed 6 months of follow-up. Two patients chose to discontinue the study. Mean ETDRS VA score improved from 55 letters at baseline to 60 letters at 1 week (P < 0...

  3. Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration

    Science.gov (United States)

    Zhang, Leilei; Xu, Jeff; Huang, Jiwei; Roberts, Cynthia; Xu, Ronald

    2010-02-01

    Bevacizumab (Avastin) has been used as one of the anti-VEGF therapies to manage neovascular age-related macular degeneration (AMD). The drug delivery system for bevacizumab needs to be improved in order to decrease the frequency of injection and reduce the adverse effects. In our study, bevacizumab was conjugated with poly (lactic-co-glycolic acid) (PLGA) microbubbles by activating carboxyl functional groups. The averaged size of microbubbles was estimated 1.055+/-0.258μm, allowing for ultrasound guided drug delivery. The binding efficiency between bevacizumab and microbubbles was evaluated in an enzyme-linked immunosorbent assay plate. The test results demonstrated the potential of using PLGA microbubbles to deliver bevacizumab with imaging guidance.

  4. Fermi GBM: Highlights from the First Year

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2009-01-01

    The Fermi Gamma ray Burst Monitor is an all-sky instrument sensitive to photons from about 8 keV to 40 MeV. I will summarize highlights from the first year, including triggered observations of gamma ray bursts, soft gamma ray repeaters, and terrestrial gamma flashes, and observations in the continuous data of X-ray binaries and accreting X-ray pulsars. GBM provides complementary observations to Swift/BAT, observing many of the same sources, but over a wider energy range.

  5. Modeling the Afterglow of GW150914-GBM

    CERN Document Server

    Morsony, Brian J; Ryan, Dominic M

    2016-01-01

    We model the afterglow of the Fermi GBM event associated with LIGO detection GW150914, under the assumption that the gamma-ray are produced by a short GRB-like relativistic outflow. We model GW150914-GBM as both a weak, on-axis short GRB and normal short GRB seen far off axis. Given the large uncertainty in the position of GW150914, we determine that the best chance of finding the afterglow is with the MWA, with the flux from an off-axis short GRB reaching 0.1 - 10 mJy at 150 MHz by 1 - 12 months after the initial event. At low frequencies, the source would evolve from a hard to soft spectrum over several months. The radio afterglow would be detectable for several months to years after it peaks, meaning the afterglow may still be detectable and increasing in brightness NOW. With a localization from the MWA, the afterglow would be detectable at higher radio frequencies with the ATCA and in X-rays Chandra or XMM.

  6. A Proposal to Localize Fermi GBM GRBs Through Coordinated Scanning of the GBM Error Circle via Optical Telescopes

    Science.gov (United States)

    Ukwatta, T. N.; Linnemann, J. T.; Tollefson, K.; Abeysekara, A. U.; Bhat, P. N.; Sonbas, E.; Gehrels, N.

    2011-01-01

    We investigate the feasibility of implementing a system that will coordinate ground-based optical telescopes to cover the Fermi GBM Error Circle (EC). The aim of the system is to localize GBM detected GRBs and facilitate multi-wavelength follow-up from space and ground. This system will optimize the observing locations in the GBM EC based on individual telescope location, Field of View (FoV) and sensitivity. The proposed system will coordinate GBM EC scanning by professional as well as amateur astronomers around the world. The results of a Monte Carlo simulation to investigate the feasibility of the project are presented.

  7. A Proposal to Localize Fermi GBM GRBs Through Coordinated Scanning of the GBM Error Circle via Optical Telescopes

    OpenAIRE

    Ukwatta, T. N.; Linnemann, J. T.; Tollefson, K.; Abeysekara, A. U.; Bhat, P. N.; Sonbas, E.; Gehrels, N.

    2011-01-01

    We investigate the feasibility of implementing a system that will coordinate ground-based optical telescopes to cover the Fermi GBM Error Circle (EC). The aim of the system is to localize GBM detected GRBs and facilitate multi-wavelength follow-up from space and ground. This system will optimize the observing locations in the GBM EC based on individual telescope location, Field of View (FoV) and sensitivity. The proposed system will coordinate GBM EC scanning by professional as well as amateu...

  8. A Prospective, Randomized Comparison of Intravitreal Triamcinolone Acetonide Versus Intravitreal Bevacizumab (Avastin) in Diffuse Diabetic Macular Edema

    OpenAIRE

    Shahin Maha; El-Lakkany Rasheed

    2010-01-01

    Purpose: To compare the functional and anatomical outcomes following intravitreal triamcinolone acetonide vs. intravitreal bevacizumab (Avastin) treatment for diffuse diabetic macular edema. Materials and Methods: In this prospective, randomized study, subjects were divided into two groups: 24 eyes that received intravitreal injection of 4 mg/0.1 mL triamcinolone acetonide (IVTA group) and 24 eyes received intravitreal injection of 1.25 mg/0.05 mL bevacizumab (IVB group). Changes in best ...

  9. All-Sky Monitoring of Variable Sources with Fermi GBM

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Cherry, Michael L.; Case, Gary L.; Camero-Arranz, Ascension; Chaplin, Vandiver; Connaughton, Valerie; Finger, Mark H.; Jenke, Pater; Rodi, James C.; Baumgartner, Wayne H.; Beklen, Elif; Bhat, P. Narayana; Briggs, Michael S.; Gehrels, Neil; Greiner, Jochen; Jahoda, Keith; Kippen, R. Marc; Kouveliotou, Chryssa; Krimm, Hans A.; Kuulkers, Erik; Lund, Niels; Meegan, Charles A.; Natalucci, Lorenzo; Paciesas, William S.; Preece, Robert

    2011-01-01

    This slide presentation reviews the monitoring of variable sources with the Fermi Gamma Ray Burst Monitor (GBM). It reviews the use of the Earth Occultation technique, the observations of the Crab Nebula with the GBM, and the comparison with other satellite's observations. The instruments on board the four satellites indicate a decline in the Crab from 2008-2010.

  10. Untriggered Swift-GRBs in Fermi/GBM data

    CERN Document Server

    Gruber, David

    2012-01-01

    The Fermi Gamma-Ray Burst Monitor (GBM) onboard the Fermi spacecraft currently operates on several trigger algorithms on various time scales and energy ranges. Motivated by the pursuit of faint Gamma-Ray Bursts (e.g. the elusive class of postulated low-luminosity GRBs), here we present the search for untriggered GRBs in the GBM data stream. To this end, I will demonstrate the methods and algorithms which have been developed by the GBM team. As a preliminary result, I am going to highlight the spectral analysis of GRBs which triggered the Swift satellite, but not GBM, and came from positions above the horizon, with a favorable orientation to at least one GBM detector. The properties of these GRBs are then compared to the full sample of GBM GRBs published in the GBM spectral catalogue. We estimate that the lower limit for untriggered GRBs in the GBM data is about 1.6 GRBs per month which corresponds to about 7% of the triggered GRBs

  11. Untriggered Swift-GRBs in Fermi/GBM data

    OpenAIRE

    Gruber, David; Collaboration, for the Fermi GBM

    2012-01-01

    The Fermi Gamma-Ray Burst Monitor (GBM) onboard the Fermi spacecraft currently operates on several trigger algorithms on various time scales and energy ranges. Motivated by the pursuit of faint Gamma-Ray Bursts (e.g. the elusive class of postulated low-luminosity GRBs), here we present the search for untriggered GRBs in the GBM data stream. To this end, I will demonstrate the methods and algorithms which have been developed by the GBM team. As a preliminary result, I am going to highlight the...

  12. The Fermi-GBM X-ray burst monitor

    Science.gov (United States)

    Linares, M.; Fermi GBM X-ray Burst Collaboration

    2010-12-01

    We discuss the first results of the Fermi-GBM all-sky search for X-ray bursts. The very large field of view and X-ray response of the Fermi-GBM make it a unique instrument to study rare, bright and short-lived X-ray bursts. We are performing a systematic search that exploits such capabilities. We present results on long/intermediate type I X-ray bursts, an unusual kind of thermonuclear bursts from accreting neutron stars, and show how Fermi-GBM is giving for the first time robust measurements of their recurrence time.

  13. Comparative analyses of gene copy number and mRNA expression in GBM tumors and GBM xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, J. Graeme; Yeh, Ru-Fang; Ray, Amrita; Wang, Nicholas J.; Smirnov, Ivan; Yu, Mamie; Hariono, Sujatmi; Silber, Joachim; Feiler, Heidi S.; Gray, Joe W.; Spellman, Paul T.; Vandenberg, Scott R.; Berger, Mitchel S.; James, C. David

    2009-04-03

    Development of model systems that recapitulate the molecular heterogeneity observed among glioblastoma multiforme (GBM) tumors will expedite the testing of targeted molecular therapeutic strategies for GBM treatment. In this study, we profiled DNA copy number and mRNA expression in 21 independent GBM tumor lines maintained as subcutaneous xenografts (GBMX), and compared GBMX molecular signatures to those observed in GBM clinical specimens derived from the Cancer Genome Atlas (TCGA). The predominant copy number signature in both tumor groups was defined by chromosome-7 gain/chromosome-10 loss, a poor-prognosis genetic signature. We also observed, at frequencies similar to that detected in TCGA GBM tumors, genomic amplification and overexpression of known GBM oncogenes, such as EGFR, MDM2, CDK6, and MYCN, and novel genes, including NUP107, SLC35E3, MMP1, MMP13, and DDX1. The transcriptional signature of GBMX tumors, which was stable over multiple subcutaneous passages, was defined by overexpression of genes involved in M phase, DNA replication, and chromosome organization (MRC) and was highly similar to the poor-prognosis mitosis and cell-cycle module (MCM) in GBM. Assessment of gene expression in TCGA-derived GBMs revealed overexpression of MRC cancer genes AURKB, BIRC5, CCNB1, CCNB2, CDC2, CDK2, and FOXM1, which form a transcriptional network important for G2/M progression and/or checkpoint activation. Our study supports propagation of GBM tumors as subcutaneous xenografts as a useful approach for sustaining key molecular characteristics of patient tumors, and highlights therapeutic opportunities conferred by this GBMX tumor panel for testing targeted therapeutic strategies for GBM treatment.

  14. GBM Observations of Terrestrial Gamma-Ray Flashes

    Science.gov (United States)

    Briggs, M. S.; Fishman, G. J.; Connaughton, V.; Bhat, P. N.; Paciesas, W. S.; Preece, R. D.; Wilson-Hodge, C.; Chaplin, V. L.; Kippen, R. M.; vonKienlin, A.; Meegan, C. A.

    2010-01-01

    The TGF detection rate of Gamma-ray Burst Monitor (GBM) has been increased twice since launch. The most recent improvement is from a new operating mode in which data for individual photons are down-linked for selected portions of the orbit, enabling a more sensitive ground-based search for TGFs. The new search has increased the TGF detection rate and is finding TGFs more than five times fainter than the TGFs of the previous GBM sample. We summarize the properties of the original GBM TGF sample and compare to the less intense TGFs now being detected. In addition to gamma-ray TGFs, GBM is observing distant TGFs from the propagation of charged particles along geomagnetic field lines. Strong 511 keV annihilation lines have been observed, demonstrating that both electrons and positrons are present in the particle beams. Spectral fits to these electron/positron TGFs will be shown.

  15. Magnetar Observations in the Swift-Fermi/GBM Era

    Science.gov (United States)

    Kouveliotou, Chryssa

    2010-01-01

    NASA's Fermi Observatory was launched June 11, 2008; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. Since then, and against all odds, GBM recorded over 600 bursts from 4 SGRs. Of these four sources, only one was an old magnetar: SGR J1806+20. SGR J0501+4516, was discovered with Swift and extensively monitored with GBM. A source originally classified as AXP 1E1547.0-5408 exhibited SGR-like bursting behavior and we reclassified it as SGR J1550-5418. Finally, GBM discovered SGR J0418+5729 on 2009 June. Finally, on March 2010, a third new magnetar was discovered with Swift, SGR J1833-0832. I report below on the current status of the field and on several results combining multi-satellite and ground-based data

  16. GBM heterogeneity characterization by radiomic analysis of phenotype anatomical planes

    Science.gov (United States)

    Chaddad, Ahmad; Desrosiers, Christian; Toews, Matthew

    2016-03-01

    Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system, characterized among other traits by rapid metastatis. Three tissue phenotypes closely associated with GBMs, namely, necrosis (N), contrast enhancement (CE), and edema/invasion (E), exhibit characteristic patterns of texture heterogeneity in magnetic resonance images (MRI). In this study, we propose a novel model to characterize GBM tissue phenotypes using gray level co-occurrence matrices (GLCM) in three anatomical planes. The GLCM encodes local image patches in terms of informative, orientation-invariant texture descriptors, which are used here to sub-classify GBM tissue phenotypes. Experiments demonstrate the model on MRI data of 41 GBM patients, obtained from the cancer genome atlas (TCGA). Intensity-based automatic image registration is applied to align corresponding pairs of fixed T1˗weighted (T1˗WI) post-contrast and fluid attenuated inversion recovery (FLAIR) images. GBM tissue regions are then segmented using the 3D Slicer tool. Texture features are computed from 12 quantifier functions operating on GLCM descriptors, that are generated from MRI intensities within segmented GBM tissue regions. Various classifier models are used to evaluate the effectiveness of texture features for discriminating between GBM phenotypes. Results based on T1-WI scans showed a phenotype classification accuracy of over 88.14%, a sensitivity of 85.37% and a specificity of 96.1%, using the linear discriminant analysis (LDA) classifier. This model has the potential to provide important characteristics of tumors, which can be used for the sub-classification of GBM phenotypes.

  17. Fermi GBM Counterparts to LIGO Gravitational-Wave Candidates

    Science.gov (United States)

    Burns, Eric; Blackburn, Lindy; Briggs, Michael Stephen; Camp, Jordan; Christensen, Nelson; Connaughton, Valerie; Goldstein, Adam; Littenberg, Tyson; Racusin, Judith L.; Shawhan, Peter S.; Pound Singer, Leo; Veitch, John; Zhang, Binbin

    2016-04-01

    As the advanced configuration of the Laser Interferometer Gravitational-wave Observatory has begun operations, we eagerly anticipate the detection of gravitational waves (GW) with LIGO in coincidence with a gamma-ray signal from the Fermi Gamma-ray Burst Monitor (GBM). The most likely source is a short Gamma-Ray Burst (GRB) arising from the merger of two compact objects. With its broad sky coverage, GBM triggers and localizes more short GRBs than other active space missions, ~40 each year. Combining GBM and LIGO localization uncertainty regions may provide a smaller target to look for the GW host. A joint GBM-LIGO detection increases the confidence in the GW detection and helps characterize the parameters of the merger. Offline searches for weak GRBs that fail to trigger onboard Fermi indicate that additional short GRBs can be detected in the GBM data. I will discuss the implementation and expected benefits of joint searches to detect and localize GW candidates. I will also explore how the non-detection in the GBM data of a signal consistent with GW candidates in the LIGO data can affect follow-up strategies for counterpart searches by other observers.

  18. Role of avastin on the incidence of post-operative vitreous hemorrhage after vitrectomy in diabetic vitreous hemorrhage

    International Nuclear Information System (INIS)

    Diabetic retinopathy is one of the most common cause of legal blindness. Five to 10% of diabetic patients suffer from the proliferative diabetic retinopathy which includes the formation of new vessels on the retina and optic disc which can be complicated as vitreous hemorrhage and tractional retinal detachment. Pars plana vitrectomy along with laser photocoagulation is being used for the management of vitreous hemorrhage. In our study we used injection avastin one week before surgery to see its role on the incidence of rebleed after vitrectomy in diabetic vitreous hemorrhage. Materials and Methods; Fifty patients were divided into 2 equal groups on the basis of simple random sampling. 25 patients in Group I were operated with routine pars plana vitrectomy with endolaser photo- coagulation while in Group II all the 25 patients were given injection avastin intra-vitreally one week before surgery. Evaluation was done on the first post operative day, first follow up visit (one week) and after one month to see the incidence of re-bleed. Chi-square test was used for statistical analysis. Results: Fifty patients divided into two groups. In Group I, 3 patients had recurrent vitreous hemorrhage on first post-operative day, 3 patients had re-bleed on first follow up visit, and only 2 patients had re-bleed after one month. In Group II, none of the patients had recurrent vitreous hemorrhage on first post-operative day and on first follow-up visit (one week) while 2 patients had re-bleed after one month. Conclusion: Injection intravitreal Avastin (Bevaci- zumab) one week before surgery significantly reduces the risk of vitreous hemorrhage after vitrectomy in diabetic patients. (author)

  19. Intravitreal bevacizumab (Avastin treatment of diffuse diabetic macular edema in an Indian population

    Directory of Open Access Journals (Sweden)

    Kumar Atul

    2007-01-01

    Full Text Available Background: To report the anatomic and visual acuity response after intravitreal bevacizumab (Avastin in patients with diffuse diabetic macular edema. Design: Prospective, interventional case series study. Materials and Methods: This study included 20 eyes of metabolically stable diabetes mellitus with diffuse diabetic macular edema with a mean age of 59 years who were treated with two intravitreal injections of bevacizumab 1.25 mg in 0.05 ml six weeks apart. Main outcome measures were 1 early treatment diabetic retinopathy study visual acuity, 2 central macular thickness by optical coherence tomography imaging. Each was evaluated at baseline and follow-up visits. Results: All the eyes had received some form of laser photocoagulation before (not less than six months ago, but all of these patients had persistent diffuse macular edema with no improvement in visual acuity. All the patients received two injections of bevacizumab at an interval of six weeks per eye. No adverse events were observed, including endophthalmitis, inflammation and increased intraocular pressure or thromboembolic events in any patient. The mean baseline acuity was 20/494 (log Mar=1.338±0.455 and the mean acuity at three months following the second intravitreal injection was 20/295 (log Mar=1.094±0.254, a difference that was highly significant ( P =0.008. The mean central macular thickness at baseline was 492 µm which decreased to 369 µm ( P =0.001 at the end of six months. Conclusions: Initial treatment results of patients with diffuse diabetic macular edema not responding to previous photocoagulation did not reveal any short-term safety concerns. Intravitreal bevacizumab resulted in a significant decrease in macular thickness and improvement in visual acuity at three months but the effect was somewhat blunted, though still statistically significant at the end of six months.

  20. Clinical, legal and ethical implications of the intra-ocular (off-label) use of bevacizumab (avastin)--a South African perspective.

    Science.gov (United States)

    Jansen, Rita-Marié; Gouws, Chris

    2009-06-01

    Choroidal neovascularisation is a potentially visually devastating element of various forms of eye pathology. Recent research has focused on neurovascular age-related macular degeneration (AMD) as a cause. AMD can be classified as being exudative (wet) or atrophic (dry). Wet AMD is characterised by a pathological process in which new blood vessels develop in the choroids, causing leakage of fluid and haemorrhage under the retina and leading to localised serous detachment and loss of central vision. Vascular endothelial growth factor (VEGF) stimulates growth of neovascular membranes. Treatments have until recently yielded disappointing results. Ophthalmologists are using intra-ocular injections of bevacizumab (Avastin), an anti-VEGF, to treat AMD. Avastin appears to be safe and effective in the short term, but its intra-ocular administration is entirely off-label. Avastin is registered for treating metastatic colorectal and breast cancer. The off-label use of medication is an important part of mainstream, legitimate medical practice worldwide. Lawyers representing plaintiffs injured by drugs increasingly encounter off-label use claims. From a legal/ethical point of view the off-label use of medication represents a delicate balance between the statutory regulation of medication and a physician's prerogative to prescribe medication that in his or her medical opinion will be beneficial to the patient. The main reason for the controversy created by the off-label use of Avastin is that there are anti-VEGF drugs on the market that have formal approval for the treatment of AMD (and other eye conditions). Lucentis, for example, is extremely expensive, with treatment cost approximately 50 times that of Avastin. Many patients suffering from AMD and macular oedema cannot afford the registered product. The off-label use of Avastin has passed the innovative or experimental stages, as ophthalmologists have used it regularly and openly for a long time, with good success. Such use

  1. The Five Year Fermi/GBM Magnetar Burst Catalog

    Science.gov (United States)

    Collazzi, A. C.; Kouveliotou, C.; van der Horst, A. J.; Younes, G. A.; Kaneko, Y.; Göğüş, E.; Lin, L.; Granot, J.; Finger, M. H.; Chaplin, V. L.; Huppenkothen, D.; Watts, A. L.; von Kienlin, A.; Baring, M. G.; Gruber, D.; Bhat, P. N.; Gibby, M. H.; Gehrels, N.; McEnery, J.; van der Klis, M.; Wijers, R. A. M. J.

    2015-05-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  2. The Five Year Fermi/GBM Magnetar Burst Catalog

    CERN Document Server

    Collazzi, A C; van der Horst, A J; Younes, G A; Kaneko, Y; Gogus, E; Lin, L; Granot, J; Finger, M H; Chaplin, V L; Huppenkothen, D; Watts, A L; von Kienlin, A; Baring, M G; Gruber, D; Bhat, P N; Gibby, M H; Gehrels, N; McEnery, J; van der Klis, M; Wijers, R A M J

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here we present the Fermi/GBM magnetar catalog, giving the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from July 2008 to June 2013. We provide durations, spectral parameters for various models, fluences and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  3. Fermi GBM Observations of LIGO Gravitational Wave event GW150914

    CERN Document Server

    Connaughton, V; Goldstein, A; Briggs, M S; Zhang, B -B; Hui, C M; Jenke, P; Racusin, J; Wilson-Hodge, C A; Bhat, P N; Cleveland, W; Fitzpatrick, G; Giles, M M; Gibby, M H; Greiner, J; von Kienlin, A; Kippen, R M; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O; Sparke, L; Stanbro, M; Toelge, K; Veres, P; Yu, H -F; authors, other

    2016-01-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO)event GW150914 reveal the presence of a weak transient source above 50 keV, 0.4 s after the GW event was detected, with a false alarm probability of 0.0022. This weak transient lasting 1 s does not appear connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event suggest it is a weak short Gamma-Ray Burst arriving at a large angle to the direction in which Fermi was pointing, where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, this electromagnetic signal from a stellar mass black hole binary merger is unexpected....

  4. Clinical and histological findings after intravitreal injection of bevacizumab (Avastin) in a porcine model of choroidal neovascularization

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik; Kiilgaard, Jens Folke; la Cour, Morten

    2010-01-01

    PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes by...... perforating Bruch's membrane with a retinal perforator. After closure of the ports used for the vitrectomy, which was performed to facilitate the Bruch's membrane rupture, 0.05 ml of either bevacizumab or Ringer-Lactat (placebo) was injected into the vitreous cavity. Eyes were enucleated after 14 days. Fundus...... photographs and fluorescein angiograms (FAs) were obtained immediately prior to enucleation. Sections of formalin- and paraffin-embedded eyes were examined by light microscopy and by immunohistochemical staining. RESULTS: Placebo-injected eyes exhibited the highest propensity to leak, with five of six eyes...

  5. Clinical and histological findings after intravitreal injection of bevacizumsb (Avastin®) in a porcine model of choroidal neovascularisation

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik; Kiilgaard, Jens Folke; Dornonville de la Cour, Morten

    2010-01-01

    PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes by...... perforating Bruch's membrane with a retinal perforator. After closure of the ports used for the vitrectomy, which was performed to facilitate the Bruch's membrane rupture, 0.05 ml of either bevacizumab or Ringer-Lactat (placebo) was injected into the vitreous cavity. Eyes were enucleated after 14 days. Fundus...... photographs and fluorescein angiograms (FAs) were obtained immediately prior to enucleation. Sections of formalin- and paraffin-embedded eyes were examined by light microscopy and by immunohistochemical staining. RESULTS: Placebo-injected eyes exhibited the highest propensity to leak, with five of six eyes...

  6. High-energy transients with Fermi/GBM

    International Nuclear Information System (INIS)

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These γ-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of γ-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in γ-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (Epeak) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility. Finally, I present the results of the search for untriggered GRBs in GBM data. This

  7. Recruitment of bone marrow derived cells during anti-angiogenic therapy in GBM : Bone marrow derived cell in GBM

    NARCIS (Netherlands)

    Boer, Jennifer C.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Glioblastoma (GBM) is a highly vascular tumor characterized by rapid and invasive tumor growth, followed by oxygen depletion, hypoxia and neovascularization, which generate a network of disorganized, tortuous and permeable vessels. Recruitment of bone marrow derived cells (BMDC) is crucial for vascu

  8. Violation of Einstein's Equivalence Principle on Gravitational Wave Event GW150914 Associated with GBM Transient GW150914-GBM

    CERN Document Server

    Liu, Molin; You, Xiaohe; Lu, Jianbo; Xu, Lixin

    2016-01-01

    In this paper, we test Einstein's equivalence principle (EEP) about gravitational wave transient GW150914 associated with weak electromagnetic signal GW150914-GBM observed by Gamma-ray Burst Monitor (GBM). We study the differences of parametrized post Newtonian (PPN) parameter $\\gamma$ between different particles in LIGO and GBM including the initial outburst gravitons and photons, the gravitons with frequency from 35 to 250 Hz and the photons in hard X-ray emission between 1 KeV and 10 MeV. The calculations are performed on the possible localizations of GW150914 which contains a best fit localization with $68\\%$ statistical uncertainty region over 9000 square degrees and the 11 sky locations with $5^{\\circ}$ apart on LIGO localization arc being visible to GBM. The results show that the violation of EEP, at least on the order of magnitude, is quite insensitive to the location of source. The initial outburst gravitons give us a very tight constrain on the violation of EEP and the accuracy is up to at least $10...

  9. 40 CFR 180.1097 - GBM-ROPE; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false GBM-ROPE; exemption from the... Exemptions From Tolerances § 180.1097 GBM-ROPE; exemption from the requirement of a tolerance. The grape berry moth pheromone (GBM-ROPE) containing the active ingredients (Z)-9-dedecenyl acetate and...

  10. Direction Dependent Background Fitting for the Fermi GBM Data

    CERN Document Server

    Szécsi, Dorottya; Kóbori, József; Horváth, István; Balázs, Lajos G

    2013-01-01

    We present a method for determining the background of Fermi GBM GRBs using the satellite positional information and a physical model. Since the polynomial fitting method typically used for GRBs is generally only indicative of the background over relatively short timescales, this method is particularly useful in the cases of long GRBs or those which have Autonomous Repoint Request (ARR) and a background with much variability on short timescales. We give a Direction Dependent Background Fitting (DDBF) method for separating the motion effects from the real data and calculate the duration (T90 and T50, as well as confidence intervals) of the nine example bursts, from which two resulted an ARR. We also summarize the features of our method and compare it qualitatively with the official GBM Catalogue. Our background filtering method uses a model based on the physical information of the satellite position. Therefore, it has many advantages compared to previous methods. It can fit long background intervals, remove all...

  11. GBM Observations of Be X-Ray Binary Outbursts

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Finger, M. H.; Jenke, P. A.

    2014-01-01

    Since 2008 we have been monitoring accreting pulsars using the Gamma ray Burst Monitor (GBM) on Fermi. This monitoring program includes daily blind full sky searches for previously unknown or previously quiescent pulsars and source specific analysis to track the frequency evolution of all detected pulsars. To date we have detected outbursts from 23 transient accreting pulsars, including 21 confirmed or likely Be/X-ray binaries. I will describe our techniques and highlight results for selected pulsars.

  12. Fermi GBM Observations of Terrestrial Gamma-Ray Flashes

    Science.gov (United States)

    Wilson-Hodge, Colleen A.; Briggs, M. S.; Connaughton, V.; Fishman, G. J.; Bhat, P. N.; Paciesas, W. S.; Preece, R.; Kippen, R. M.; vonKienlin, A.; Dwyer, J. R.; Smith, D. M.; Holzworth, R.

    2010-01-01

    This slide presentation explores the relationship between Terrestrial Gamma-Ray Flashes (TGF) and lightning. Using data from the World-Wide Lightning Location Network (WWLLN), and the gamma ray observations from Fermi's Gamma-ray Burst Monitor (GBM), the study reviews any causal relationship between TGFs and lightning. The conclusion of the study is that the TGF and lightning are simultaneous with out a causal relationship.

  13. Fermi GBM signal contemporaneous with GW150914 - an unlikely association

    CERN Document Server

    Lyutikov, Maxim

    2016-01-01

    We argue that the physical constraints required by the association of the Fermi GBM signal contemporaneous with GW150914 - radiative power of $10^{49} $ erg s$^{-1}$, and corresponding magnetic fields on the black hole of the order of $10^{12}$ Gauss - are astrophysical highly implausible. Combined with the relatively high random probability of coincidence of 0.22 percents, we conclude that the electromagnetic signal is likely unrelated to the BH merger.

  14. An exploration of counterfeit medicine surveillance strategies guided by geospatial analysis: lessons learned from counterfeit Avastin detection in the US drug supply chain

    OpenAIRE

    Cuomo, Raphael E.; Mackey, Tim K.

    2014-01-01

    Objective To explore healthcare policy and system improvements that would more proactively respond to future penetration of counterfeit cancer medications in the USA drug supply chain using geospatial analysis. Design A statistical and geospatial analysis of areas that received notices from the Food and Drug Administration (FDA) about the possibility of counterfeit Avastin penetrating the US drug supply chain. Data from FDA warning notices were compared to data from 44 demographic variables a...

  15. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    Science.gov (United States)

    Hurley, K.; Briggs, M.; Connaughton, V.; Meegan, C.; von Kienlin, A.; Rau, A.; Zhang, X.; Golenetskii, S.; Aptekar, R.; Mazets, E.; Pal'shin, V.; Fredericks, D.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Starr, R.; Goldsten, J.

    2012-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  16. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    CERN Document Server

    Hurley, K; Connaughton, V; Meegan, C; von Kienlin, A; Rau, A; Zhang, X; Golenetskii, S; Aptekar, R; Mazets, E; Pal'shin, V; Frederiks, D; Barthelmy, S; Cline, T; Cummings, J; Gehrels, N; Krimm, H A; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Starr, R; Smith, D M; Hajdas, W; Yamaoka, K; Ohno, M; Fukazawa, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Palmer, D M; Goldsten, J; Del Monte, E; Feroci, M; Marisaldi, M

    2011-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  17. High-energy transients with Fermi/GBM

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, David

    2012-10-09

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These {gamma}-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of {gamma}-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in {gamma}-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (E{sub peak}) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility

  18. A prospective, randomized comparison of intravitreal triamcinolone acetonide versus intravitreal bevacizumab (avastin in diffuse diabetic macular edema

    Directory of Open Access Journals (Sweden)

    Shahin Maha

    2010-01-01

    Full Text Available Purpose: To compare the functional and anatomical outcomes following intravitreal triamcinolone acetonide vs. intravitreal bevacizumab (Avastin treatment for diffuse diabetic macular edema. Materials and Methods: In this prospective, randomized study, subjects were divided into two groups: 24 eyes that received intravitreal injection of 4 mg/0.1 mL triamcinolone acetonide (IVTA group and 24 eyes received intravitreal injection of 1.25 mg/0.05 mL bevacizumab (IVB group. Changes in best corrected visual acuity (BCVA, intraocular pressure (IOP, baseline fluorescein angiography and optical coherence tomography measurements were evaluated in both groups. Follow-up visits out to three months from baseline are reported. Results: One month after treatment, baseline foveal thickness decreased from 452 μ to 299 μ in the IVTA group and from 292 μ to 270 μ in the IVB group. BCVA increased by two or more lines in 58.3% of eyes in the IVTA group and there was no similar improvement in the IVB group. In the IVTA group, a transient increase in IOP (27-43 mmHg occurred in four cases (16.7%, which was successfully controlled with topical medications. There were no complications in the IVB group. Conclusion: Short term outcomes indicate that intravitreal injection of bevacizumab was not associated with surgical complications compared to triamcinolone acetonide. Triamcinolone acetonide appears to be more effective treatment for diabetic macular edema than bevacizumab.

  19. Tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin®: relato de caso Treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin®: case report

    Directory of Open Access Journals (Sweden)

    Marcelo Mendes Lavezzo

    2010-08-01

    Full Text Available OBJETIVO: Relatar tratamento de retinopatia por radiação em paciente submetido à radioterapia por linfoma em órbita direita com injeção intravítrea de bevacizumab (Avastin®. Paciente de 55 anos, diabético, com diagnóstico de linfoma MALT orbitário há três anos, tratado com radioterapia local (dose: 35Gy há dois anos, com queixa de redução da acuidade visual do olho direito há quatro meses. Ao exame oftalmológico, apresentava alterações sugestivas de retinopatia por radiação, bem como espessura macular à tomografia de coerência óptica de 480 µm. Paciente foi submetido à injeção intravítrea (0,05 ml de bevacizumab (Avastin® no olho direito, apresentando redução do edema macular, bem como melhora discreta da acuidade visual. Neste caso, o tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin® foi relativamente útil, com melhora discreta da acuidade visual, devido à regressão do edema macular.PURPOSE: To report a case of radiation retinopathy treatment with intravitreal injection of bevacizumab (Avastin® in a patient undergoing radiotherapy for lymphoma in the right orbit. Patient of 55 years-old male, diabetic, diagnosed with an orbital MALT lymphoma three years ago, treated with local radiotherapy (dose: 35Gy two years ago, complaining of reduced visual acuity of the right eye for about four months. During the ophthalmologic evaluation, he had an exam suggestive of radiation retinopathy. Macular thickness at the optical coherence tomography was 480 µm. Patient was referred to intravitreal injection (0.05 ml of bevacizumab (Avastin® in the right eye, showing reduction of macular edema and mild improvement of visual acuity. In this case, the treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin® was relatively useful, with mild improvement of visual acuity due to the regression of macular edema.

  20. Surprisal Analysis of Glioblastoma Multiform (GBM) MicroRNA Dynamics Unveils Tumor Specific Phenotype

    OpenAIRE

    Zadran, Sohila; Remacle, Françoise; Levine, R. D.

    2014-01-01

    Gliomablastoma multiform (GBM) is the most fatal form of all brain cancers in humans. Currently there are limited diagnostic tools for GBM detection. Here, we applied surprisal analysis, a theory grounded in thermodynamics, to unveil how biomolecule energetics, specifically a redistribution of free energy amongst microRNAs (miRNAs), results in a system deviating from a non-cancer state to the GBM cancer –specific phenotypic state. Utilizing global miRNA microarray expression data of normal an...

  1. AI-05IMPACT OF GBM MICROENVIRONMENT ON EXPRESSION PROFILE OF BONE MARROW DERIVED PROGENITOR CELLS

    OpenAIRE

    Burrell, Kelly; Singh, Sanjay; Agnihotri, Sameer; Hill, Richard; Aldape, Kenneth; Zadeh, Gelareh

    2014-01-01

    We have recently shown that bone marrow derived cells (BMDC) provide a distinct tumor region dependent contribution to glioblastoma multiforme (GBM) neovascularization. The influence of GBM microenvironment on differentiation and modulation of expression factors by BMDC however remains unknown. In this study we establish the differential expression profile of BMDC as a consequence of recruitment and interaction with the GBM microenvironment and in response to radiation (RTx) and anti-angiogen...

  2. THE FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST TWO YEARS

    OpenAIRE

    Paciesas, W. S.; Meegan, C. A.; Kienlin, von, A.; Bhat, P.N.; Bissaldi, E.; Briggs, M S; Burgess, M; Chaplin, V.; Connaughton, V.; Diehl, R.; Fishman, G. J.; Fitzpatrick, G.; Foley, S.; Gibby, H., M.; Giles, M

    2012-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are availab...

  3. Fermi/GBM and BATSE Gamma-Ray Bursts: comparison of the spectral properties

    OpenAIRE

    Nava, Lara; Ghirlanda, Giancarlo; Ghisellini, Gabriele; Celotti, Annalisa

    2010-01-01

    The Gamma-ray Burst Monitor (GBM) on board Fermi allows to study the spectra of Gamma Ray Bursts (GRBs) over an unprecedented wide energy range (8 keV - 35 MeV). We compare the spectral properties of short and long GRBs detected by the GBM (up to March 2010) with those of GRBs detected by the BATSE instrument on board the CGRO. GBM and BATSE long bursts have similar distributions of fluence (F), Epeak and peak flux (P) but GBM bursts have a slightly harder low-energy spectral index \\alpha wit...

  4. The Second Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    OpenAIRE

    Kienlin, von, A.; Meegan, C. A.; Paciesas, W. S.; Bhat, P.N.; Bissaldi, E.; Briggs, M S; Burgess, J. M.; Byrne, D.; Chaplin, V.; Cleveland, W.; Connaughton, V.; Collazzi, A.C.; Fitzpatrick, G.; Foley, S.; Gibby, M.

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are deri...

  5. THE FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Paciesas, William S.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam; Guiriec, Sylvain [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, Charles A.; Van der Horst, Alexander J. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Von Kienlin, Andreas; Diehl, Roland; Foley, Suzanne; Greiner, Jochen; Gruber, David [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Bissaldi, Elisabetta [Institute of Astro and Particle Physics, University Innsbruck, Technikerstrasse 25, 6176 Innsbruck (Austria); Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., 1525 Perimeter Pkwy NW, Huntsville, AL 35806 (United States); and others

    2012-03-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  6. The Search for Type 1 X-ray Bursts with Fermi/GBM

    Science.gov (United States)

    Jenke, Peter; Linares, M.; Connaughton, V.; Camero-Arranz, A.; Finger, M. H.; WIlson-Hodge, C. A.; Van Der Horst, A.; Fermi GBM X-ray Burst Collaboration

    2012-01-01

    We discuss the first results of the Fermi-GBM all-sky search for X-ray bursts. The very large field of view and X-ray response of the Fermi-GBM make it a unique instrument to study rare, bright and short-lived X-ray bursts. We are performing a systematic search that exploits such capabilities. We present results on long/intermediate type I X-ray bursts, an unusual kind of thermonuclear bursts from accreting neutron stars, and show how Fermi-GBM is giving, for the first time, robust measurements of their recurrence time.

  7. The Fermi GBM Gamma-Ray Burst Catalog: The First Two Years

    CERN Document Server

    Paciesas, William S; von Kienlin, Andreas; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Chaplin, Vandiver; Connaughton, Valerie; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kippen, R Marc; Kouveliotou, Chryssa; Lichti, Giselher; Lin, Lin; McBreen, Sheila; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen

    2012-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  8. Computer Implementation of a New Therapeutic Model for GBM Tumor

    Directory of Open Access Journals (Sweden)

    Ali Jamali Nazari

    2014-01-01

    Full Text Available Modeling the tumor behavior in the host organ as function of time and radiation dose has been a major study in the previous decades. Here the effort in estimation of cancerous and normal cell proliferation and growth in glioblastoma multiform (GBM tumor is presented. This paper introduces a new mathematical model in the form of differential equation of tumor growth. The model contains dose delivery amount in the treatment scheme as an input term. It also can be utilized to optimize the treatment process in order to increase the patient survival period. Gene expression programming (GEP as a new concept is used for estimating this model. The LQ model has also been applied to GEP as an initial value, causing acceleration and improvement of the algorithm estimation. The model shows the number of the tumor and normal brain cells during the treatment process using the status of normal and cancerous cells in the initiation of treatment, the timing and amount of dose delivery to the patient, and a coefficient that describes the brain condition. A critical level is defined for normal cell when the patient’s death occurs. In the end the model has been verified by clinical data obtained from previous accepted formulae and some of our experimental resources. The proposed model helps to predict tumor growth during treatment process in which further treatment processes can be controlled.

  9. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

    Directory of Open Access Journals (Sweden)

    Tzuu-Yuan Huang

    2012-01-01

    Full Text Available Demethoxycurcumin (DMC; a curcumin-related demethoxy compound has been recently shown to display antioxidant and antitumor activities. It has also produced a potent chemopreventive action against cancer. In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells. We have studied the mitochondrial membrane potential (MMP, DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity. By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells. Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.

  10. Bevacizumab (Avastin®) no tratamento da membrana neovascular coroidal secundária à degeneração macular relacionada à idade: relato de caso Bevacizumab (Avastin®) in treatment of choroidal neovascularization secondary to age-related macular degeneration: a case report

    OpenAIRE

    Tiago Eugênio Faria e Arantes; Vinícius Paganini Nascimento; Otacílio de Oliveira Maia Júnior; Walter Yukihiko Takahashi

    2007-01-01

    As drogas anti-angiogênicas foram introduzidas recentemente no arsenal terapêutico das membranas neovasculares coroidais. O objetivo deste relato é descrever um caso de membranas neovasculares coroidais oculta com extenso descolamento do epitélio pigmentado da retina, tratada com bevacizumab (Avastin®) intravítrea. A eficácia da medicação foi avaliada por meio da acuidade visual e de exames complementares (angiografia fluoresceínica, videoangiografia com indocianina verde e tomografia de coer...

  11. THE INTERPLANETARY NETWORK SUPPLEMENT TO THE FERMI GBM CATALOG OF COSMIC GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Hurley, K. [University of California, Berkeley, Space Sciences Laboratory, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Pal' shin, V. D.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Mazets, E. P.; Svinkin, D. S. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Briggs, M. S.; Connaughton, V. [University of Alabama in Huntsville, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, C. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Goldsten, J. [Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723 (United States); Boynton, W.; Fellows, C.; Harshman, K. [University of Arizona, Department of Planetary Sciences, Tucson, AZ 85721 (United States); Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B. [Space Research Institute, 84/32, Profsoyuznaya, Moscow 117997 (Russian Federation); Rau, A., E-mail: khurley@ssl.berkeley.edu [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse, Postfach 1312, D-85748 Garching (Germany); and others

    2013-08-15

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 427 were observed by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could be improved by arrival time analysis (or {sup t}riangulation{sup )}. For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.'4 and 32 Degree-Sign , depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1{sigma} GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 Degree-Sign systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If we then multiply the resulting error radii by a factor of three, the two samples agree in slightly over 98% of the cases, providing a good estimate of the GBM 3{sigma} error radius. The IPN 3{sigma} error boxes have areas between about 1 arcmin{sup 2} and 110 deg{sup 2}, and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two bursts in the IPN/GBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrial gamma flash, and in the other, its origin was given as ''uncertain''. We also discuss the sensitivity and calibration of the IPN.

  12. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM

    OpenAIRE

    Srinivasan, Radhika; Phillips, Joanna J.; Vandenberg, Scott R.; Polley, Mei-Yin C.; Bourne, Gabriela; Au, Alvin; Pirzkall, Andrea; Cha, Soonmee; Chang, Susan M.; Nelson, Sarah J.

    2010-01-01

    The motivation of this study was to address the urgent clinical problem related to the inability of magnetic resonance (MR) imaging measures to differentiate tumor progression from treatment effects in patients with glioblastoma multiforme (GBM). While contrast enhancement on MR imaging (MRI) is routinely used for assessment of tumor burden, therapy response, and progression-free survival in GBM, it is well known that changes in enhancement following treatment are nonspecific to tumor. To add...

  13. THE INTERPLANETARY NETWORK SUPPLEMENT TO THE FERMI GBM CATALOG OF COSMIC GAMMA-RAY BURSTS

    International Nuclear Information System (INIS)

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 427 were observed by at least one other instrument in the nine-spacecraft IPN. Of the 427, the localizations of 149 could be improved by arrival time analysis (or triangulation). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.'4 and 32°, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1σ GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6° systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If we then multiply the resulting error radii by a factor of three, the two samples agree in slightly over 98% of the cases, providing a good estimate of the GBM 3σ error radius. The IPN 3σ error boxes have areas between about 1 arcmin2 and 110 deg2, and are, on the average, a factor of 180 smaller than the corresponding GBM localizations. We identify two bursts in the IPN/GBM sample that did not appear in the GBM catalog. In one case, the GBM triggered on a terrestrial gamma flash, and in the other, its origin was given as ''uncertain''. We also discuss the sensitivity and calibration of the IPN

  14. On the GBM event seen 0.4 sec after GW 150914

    CERN Document Server

    Greiner, J; Savchenko, V; Yu, H -F

    2016-01-01

    In view of the recent report by Connaughton [arXiv:1602.03920.v3] we analyse continuous TTE data of Fermi-GBM around the time of the gravitational wave event GW 150914. We find that after proper accounting for low count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broad-band light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  15. Is the GW150914-GBM really associated with the GW150914?

    CERN Document Server

    Xiong, Shaolin

    2016-01-01

    Finding the electromagnetic (EM) counterpart is critically important for a gravitational wave event. Although many efforts have been made to search for the purported EM counterpart of GW150914, the first gravitational wave event detected by LIGO, only Fermi/GBM reported an excess above background (i.e. GW150914-GBM) at 0.4 s after the LIGO trigger time, that is possibly associated with this GW event (Connaughton et al. 2016). However, since there is no significant detection by the INTEGRAL/SPI-ACS around the time of GW150914-GBM, a great debate has been raised about whether GW150914-GBM is of astrophysical origin and associated with the GW150914 (Savchenko et al. 2016). In order to answer this question, we re-analyzed the GBM data with a straightforward but sophisticated method. We find that the excess of GW150914-GBM mostly comes from those detectors with bad viewing angles to the GW event, whereas the good viewing detectors see nothing significant beyond background fluctuation around the trigger time of GW1...

  16. Bevacizumab (Avastin® no tratamento da membrana neovascular coroidal secundária à degeneração macular relacionada à idade: relato de caso Bevacizumab (Avastin® in treatment of choroidal neovascularization secondary to age-related macular degeneration: a case report

    Directory of Open Access Journals (Sweden)

    Tiago Eugênio Faria e Arantes

    2007-12-01

    Full Text Available As drogas anti-angiogênicas foram introduzidas recentemente no arsenal terapêutico das membranas neovasculares coroidais. O objetivo deste relato é descrever um caso de membranas neovasculares coroidais oculta com extenso descolamento do epitélio pigmentado da retina, tratada com bevacizumab (Avastin® intravítrea. A eficácia da medicação foi avaliada por meio da acuidade visual e de exames complementares (angiografia fluoresceínica, videoangiografia com indocianina verde e tomografia de coerência óptica. Após três injeções intravítreas de bevacizumab, obteve-se uma resposta anatômica e visual satisfatória, denotando benefícios da droga, apesar do extenso descolamento do epitélio pigmentado da retina associada a membranas neovasculares coroidais oculta.The antiangiogenic drugs have been recently introduced in the therapeutic armamentarium of choroidal neovascularization. The purpose of this report is to describe a case of occult choroidal neovascularization with extensive retinal pigment epithelial detachment treated with intravitreal bevacizumab (Avastin®. The efficacy of the medication was evaluated by means of visual acuity and complementary exams (fluorescein angiography, indocyanine green video angiography and optical coherence tomography. After three intravitreal injections of bevacizumab a satisfactory anatomic and visual response was achieved, showing benefits of the drug, despite the extensive retinal pigment epithelial detachment associated with occult choroidal neovascularization.

  17. Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines.

    Science.gov (United States)

    Tezcan, Gulcin; Tunca, Berrin; Bekar, Ahmet; Yalcin, Murat; Sahin, Saliha; Budak, Ferah; Cecener, Gulsah; Egeli, Unal; Demir, Cevdet; Guvenc, Gokcen; Yilmaz, Gozde; Erkan, Leman Gizem; Malyer, Hulusi; Taskapilioglu, Mevlut Ozgur; Evrensel, Turkkan; Bilir, Ayhan

    2015-03-01

    Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients is required. Induction of tumor cell death by certain phytochemicals derived from medicinal herbs and dietary plants has become a new frontier for cancer therapy research. Although the cancer suppressive effect of Ficus carica (fig) latex (FCL) has been determined in a few cancer types, the effect of this latex on GBM tumors has not been investigated. Therefore, in the current study, the anti-proliferative activity of FCL and the effect of the FCL-temozolomide (TMZ) combination were tested in the T98G, U-138 MG, and U-87 MG GBM cell lines using the WST-1 assay. The mechanism of cell death was analyzed using Annexin-V/FITC and TUNEL assays, and the effect of FCL on invasion was tested using the chick chorioallantoic membrane assay. To determine the effect of FCL on GBM progression, the expression levels of 40 GBM associated miRNAs were analyzed in T98G cells using RT-qPCR. According to the obtained data, FCL causes cell death in GBM cells with different responses to TMZ, and this effect is synergistically increased in combination with TMZ. In addition, the current study is the first to demonstrate the effect of FCL on modulation of let-7d expression, which may be an important underlying mechanism of the anti-invasive effect of this extract. PMID:25212824

  18. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  19. Rituximab for the treatment of refractory simultaneous anti-glomerular basement membrane (anti-GBM) and membranous nephropathy

    OpenAIRE

    Bandak, Ghassan; Jones, Bruce A.; Li, Jian; Yee, Jerry; Umanath, Kausik

    2014-01-01

    Antibody-mediated anti-glomerular basement membrane (anti-GBM) disease occurs rarely in the presence of another B-cell disorder, membranous nephropathy. The coexistence of these two autoimmune disorders would be anticipated to require differing, specific therapies targeted to each disease process. We describe a case of concomitant membranous nephropathy and anti-GBM disease in which conventional therapy, including steroids, plasmapheresis and cyclophosphamide, failed to attenuate the anti-GBM...

  20. RM-06IN VITRO CLONAL EVOLUTION OF GLIOBLASTOMA (GBM) BRAIN TUMOUR INITIATING CELLS (BTIC) TO MODEL TUMOUR RECURRENCE

    OpenAIRE

    Qazi, Maleeha; Vora, Parvez; Venugopal, Chitra; McFarlane, Nicole; Hallett, Robin; Singh, Sheila

    2014-01-01

    Glioblastoma (GBM) is the most common and highly aggressive primary adult brain tumour. Despite multimodal therapy, patients on average experience relapse at 9 months and median survival rarely extends beyond 15 months. Targeting the cells that drive GBM formation as well as its inevitable and rapid recurrence has remained a major challenge, likely due to intra-tumoral heterogeneity. At the genetic level, this heterogeneity has prompted a molecular classification of GBM based on differential ...

  1. Implication of the association between GBM transient 150914 and LIGO Gravitational Wave event GW150914

    CERN Document Server

    Li, Xiang; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-01-01

    On September 14, 2015 the two detectors of LIGO simultaneously detected a transient gravitational-wave signal GW150914 and the Fermi GBM observations found a weak short gamma-ray burst (SGRB)-like transient (i.e., the GBM transient 150914). The time and location coincidences favor the association between GW150904 and GBM transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event is indeed a distinct outlier in the $E_{\\rm p,rest}-E_{\\rm iso}$ and $E_{\\rm p,rest}-L_{\\gamma}$ diagrams ($E_{\\rm iso}$ is the isotropic-equivalent energy, $L_\\gamma$ is the luminosity and $E_{\\rm p,rest}$ is the rest frame peak energy of the prompt emission), possibly due to its specific binary-black-hole merger origin. However, the presence of a "new" group of SGRBs with "low" $L_\\gamma$ and $E_{\\rm iso}$ but high $E_{\\rm p,rest}$ is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, we estimate the accretion disk mass to be $\\sim 10...

  2. The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    CERN Document Server

    Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Briggs, Michael S; Burgess, J Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H; Collazzi, Andrew C; Connaughto, Valerie; Diekmann, Anne M; Fitzpatrick, Gerard; Gibby, Melissa H; Giles, Misty M; Goldstein, Adam M; Greiner, Jochen; Jenke, Peter A; Kippen, R Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D; Roberts, Oliver J; Sparke, Linda S; Stanbro, Matthew; Veres, Peter; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-01-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRB...

  3. The Second Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    Science.gov (United States)

    von Kienlin, Andreas; Meegan, Charles A.; Paciesas, William S.; Bhat, P. N.; Bissaldi, Elisabetta; Briggs, Michael S.; Burgess, J. Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C.; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J.; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinéad; Pelassa, Veronique; Preece, Robert D.; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  4. THE SECOND FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST FOUR YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Von Kienlin, Andreas; Greiner, Jochen; Gruber, David [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Meegan, Charles A.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam [University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Paciesas, William S.; Cleveland, William [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Bissaldi, Elisabetta [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Byrne, David; Fitzpatrick, Gerard; Foley, Suzanne [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Collazzi, Andrew C. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., Huntsville, AL 35806 (United States); Guiriec, Sylvain [NASA-Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  5. The 2nd Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    CERN Document Server

    von Kienlin, Andreas; Paciesas, William S; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinead; Pelassa, Veronique; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50 - 300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10 - 1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM sci...

  6. The Fermi-GBM 3-year X-ray Burst Catalog

    CERN Document Server

    Jenke, P A; Connaughton, V; Beklen, E; Camero-Arranz, A; Finger, M H; Wilson-Hodge, C A

    2016-01-01

    The Fermi Gamma Ray Burst Monitor (GBM) is an all sky gamma-ray monitor well known in the gamma-ray burst community. Although GBM excels in detecting the hard, bright extragalactic GRBs, its sensitivity above 8 keV and all-sky view make it an excellent instrument for the detection of rare, short-lived Galactic transients. In March 2010, we initiated a systematic search for transients using GBM data. We conclude this phase of the search by presenting a 3 year catalog of 1084 non-solar events. Using spectral analysis, location and spatial distributions we subdivided the 1084 events into 752 thermonuclear X-ray bursts, 267 transient events from accretion flares and X-ray pulses, and 65 untriggered gamma-ray bursts.

  7. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  8. Monitoring the Low-Energy Gamma-Ray Sky Using Earth Occultation with GLAST GBM

    Science.gov (United States)

    Case, G.; Wilson-Hodge, C.; Cherry, M.; Kippen, M.; Ling, J.; Radocinski, R.; Wheaton, W.

    2007-01-01

    Long term all-sky monitoring of the 20 keV - 2 MeV gamma-ray sky using the Earth occultation technique was demonstrated by the BATSE instrument on the Compton Gamma Ray Observatory. The principles and techniques used for the development of an end-to-end earth occultation data analysis system for BATSE can be extended to the GLAST Gamma-ray Burst Monitor (GBM), resulting in multiband light curves and time-resolved spectra in the energy range 8 keV to above 1 MeV for known gamma-ray sources and transient outbursts, as well as the discovery of new sources of gamma-ray emission. In this paper we describe the application of the technique to the GBM. We also present the expected sensitivity for the GBM.

  9. Monitoring the Low-Energy Gamma-Ray Sky Using Earth Occultation with GLAST GBM

    International Nuclear Information System (INIS)

    Long term all-sky monitoring of the 20 keV - 2 MeV gamma-ray sky using the Earth occultation technique was demonstrated by the BATSE instrument on the Compton Gamma Ray Observatory. The principles and techniques used for the development of an end-to-end earth occultation data analysis system for BATSE can be extended to the GLAST Burst Monitor (GBM), resulting in multiband light curves and time-resolved spectra in the energy range 8 keV to above 1 MeV for known gamma-ray sources and transient outbursts, as well as the discovery of new sources of gamma-ray emission. In this paper we describe the application of the technique to the GBM. We also present the expected sensitivity for the GBM

  10. Earth Occultation Monitoring of the Hard X-ray/Low-Energy Gamma Ray Sky with GBM

    Science.gov (United States)

    Cherry, Michael L.; Camero-Arranz, A.; Case, G. L.; Chaplin, V.; Finger, M. H.; Jenke, P. A.; Rodi, J. C.; Wilson-Hodge, C. A.; GBM Earth Occultation Team

    2012-01-01

    By utilizing the Earth occultation technique (EOT), the Gamma-Ray Burst Monitor (GBM) instrument aboard Fermi has been used to make nearly continuous full-sky observations in the 8-1000 keV energy range. The GBM EOT analysis program currently monitors an input catalog containing 235 sources. We will present the GBM catalog of sources observed in the first 3 years of the EOT monitoring program, with special emphasis on the high energy (>100 keV) and time-variable sources, in particular the Crab, Cyg X-1, and A0535+26. We will also describe the initial results of an all-sky imaging analysis of the EOT data, with comparisons to the Swift, INTEGRAL, and Fermi LAT catalogs. This work is supported by the NASA Fermi Guest Investigator program, NASA/Louisiana Board of Regents, and Spanish Ministerio de Ciencia de Innovacion.

  11. The Third Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    Science.gov (United States)

    Narayana Bhat, P.; Meegan, Charles A.; von Kienlin, Andreas; Paciesas, William S.; Briggs, Michael S.; Burgess, J. Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H.; Collazzi, Andrew C.; Connaughton, Valerie; Diekmann, Anne M.; Fitzpatrick, Gerard; Gibby, Melissa H.; Giles, Misty M.; Goldstein, Adam M.; Greiner, Jochen; Jenke, Peter A.; Kippen, R. Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D.; Roberts, Oliver J.; Sparke, Linda S.; Stanbro, Matthew; Veres, Péter; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-04-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two γ-ray bursts (GRBs) every three days. Here, we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years through the middle of 2014 July. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM-detected GRBs. For each GRB, the location and main characteristics of the prompt emission, the duration, peak flux, and fluence are derived. The latter two quantities are calculated for the 50–300 keV energy band where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10 to 1000 keV, exploiting the full energy range of GBM's low-energy [Nai[Tl)] detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fit by a two-component model with short-hard and long-soft bursts than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  12. Crescentic transformation in primary membranous glomerulopathy: Association with anti-GBM antibody

    International Nuclear Information System (INIS)

    Crescentic transformation of primary membranous nephropathy (MN) associated with the development of anti-GBM antibody is a rare cause of actual renal failure in patients with MN. We report a 54-years-old lady, diagnosed to have MN four years earlier, who presented with acute deterioration of renal functions. Renal biopsy revealed circumferential crescents in all glomeruli. Serum anti-GBM antibodies were positive. Despite therapy with plasmapheresis, steroids and oral cyclophosphamide, she did not improve and continues to be dialysis dependent. (author)

  13. Tratamento da retinopatia por radiação com injeção intravítrea de bevacizumab (Avastin®): relato de caso Treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin®): case report

    OpenAIRE

    Marcelo Mendes Lavezzo; Kenzo Hokazono; Walter Yukihiko Takahashi

    2010-01-01

    OBJETIVO: Relatar tratamento de retinopatia por radiação em paciente submetido à radioterapia por linfoma em órbita direita com injeção intravítrea de bevacizumab (Avastin®). Paciente de 55 anos, diabético, com diagnóstico de linfoma MALT orbitário há três anos, tratado com radioterapia local (dose: 35Gy) há dois anos, com queixa de redução da acuidade visual do olho direito há quatro meses. Ao exame oftalmológico, apresentava alterações sugestivas de retinopatia por radiação, bem como espess...

  14. VizieR Online Data Catalog: Fermi/GBM GRB minimum timescales (Golkhou+, 2015)

    Science.gov (United States)

    Golkhou, V. Z.; Butler, N. R.; Littlejohns, O. M.

    2016-01-01

    We consider 949 GRBs published in the second Fermi/GBM GRB catalog (von Kienlin et al. 2014, J/ApJS/211/13), spanning the first four years of the Fermi mission (between 2008 July 14 and 2012 July 11, inclusive). (1 data file).

  15. The Latest Space-Borne Observations of TGFs from Fermi-GBM

    Science.gov (United States)

    Fishman, Gerald J.

    2010-01-01

    The Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope Observatory (Fermi) is detecting about two TGFs per week. This rate has increased by a factor of approx.eight since launch when flight software was uploaded to the spacecraft in November 2009 in order to increase the sensitivity of GBM to TGFs. Weaker, un-triggered TGFs are now also being observed about once per day over selected low-latitude regions Americas. The high efficiency and time resolution (2 s) of GBM allows temporal features to be resolved so that some insight may be gained on the origin and transport of the gamma-ray photons through the atmosphere. TGFs are observed to be shorter than previously thought, with an average duration of approx.100 micro-s. The absolute times of TGFs are known to approx.10 micro-s, allowing accurate correlations of TGFs with lightning networks and other lightning-related phenomena. The events are observed in the thick bismuth germanate (BGO) scintillation detectors of GBM with photon energies above 40 MeV. Other new results on the temporal and spectral characteristics of TGFs will be presented, along with properties of several electron-positron TGF events that have been identified.

  16. Spectral and temporal analysis of the joint Swift/BAT-Fermi/GBM GRB sample

    CERN Document Server

    Virgili, Francisco; Zhang, Bing; Liang, Enwei

    2011-01-01

    Using the gamma-ray bursts simultaneously detected by Swift/BAT and Fermi/GBM we perform a joint spectral and temporal analysis of the prompt emission data. Using derived spectral parameters, we confirm the rough correlation between the BAT-band photon index Gamma^BAT and the peak spectral energy E_peak. With the redshift known sub-sample, we derive the isotropic gamma-ray energy E_gamma,iso and confirm the E_gamma,iso - E_peak,rest relation, with a larger scatter than the Amati sample but consistent with another analysis by the GBM team. We also compare the T_90 values derived in the GBM band with those derived in the BAT band. We find that for long GRBs the BAT T_90 is usually longer than the GBM T_90, while for short GRBs the trend reverses. This is consistent with the soft/hard nature of long/short GRBs and suggests the importance of an energy-dependent temporal analysis of GRBs.

  17. VizieR Online Data Catalog: Localizations of GRBs with Fermi GBM (Connaughton+, 2015)

    Science.gov (United States)

    Connaughton, V.; Briggs, M. S.; Goldstein, A.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Wilson-Hodge, C. A.; Gibby, M. H.; Greiner, J.; Gruber, D.; Jenke, P.; Kippen, R. M.; Pelassa, V.; Xiong, S.; Yu, H.-F.; Bhat, P. N.; Burgess, J. M.; Byrne, D.; Fitzpatrick, G.; Foley, S.; Giles, M. M.; Guiriec, S.; van der Horst, A. J.; von Kienlin, A.; McBreen, S.; McGlynn, S.; Tierney, D.; Zhang, B.-B.

    2015-03-01

    Between 2008 July and 2013 May, GBM triggered on 203 GRBs that were well-localized by other instruments or by the IPN, with location uncertainties (68% confidence level) smaller than 1°. These 203 reference locations are listed in Table 9. (2 data files).

  18. Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

    CERN Document Server

    Rodi, J; Case, G L; Camero-Arranz, A; Chaplin, C; Finger, M H; Jenke, P; Wilson-Hodge, C A

    2013-01-01

    The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. Imaging with a Differential filter using the Earth Occultation Method (IDEOM) has been developed to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT. IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky images have been generated for ~4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. Analysis resulted in the detection of 43 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. IDEOM analysis has resulted in the addition of 16 sources to the GBM-EOT catalog. We also present the first joined averaged spectra fo...

  19. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS. PMID:26249244

  20. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Kupelian, P; Kaprealian, T; Selch, M; Low, D; Pajonk, F; Sheng, K [UCLA, Los Angeles, CA (United States)

    2014-06-15

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α{sub 1} D-β{sub 1}D{sup 2}) + (1-F) × exp(-α{sub 2}D-β{sub 2}D{sup 2}) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α{sub 1}, β{sub 1}, α{sub 2}, β{sub 2})=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment

  1. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    International Nuclear Information System (INIS)

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α1 D-β1D2) + (1-F) × exp(-α2D-β2D2) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α1, β1, α2, β2)=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment outcome but still eventually recurs. Dose escalation beyond

  2. Precursors in gamma-ray bursts detected by the Fermi-LAT and GBM

    Science.gov (United States)

    Zhu, Sylvia; Fermi Large Area Telescope Collaboration

    2015-04-01

    Many aspects of gamma-ray bursts (GRBs) remain mysterious more than 40 years after their initial discovery. However, observations of GRBs by the Fermi Large Area Telescope (LAT) and Gamma-ray Burst Monitor (GBM) have uncovered new information about the observed properties and the underlying physics. In a small minority (roughly 5-20%), a dim, temporally distinct precursor peak occurs before the brightest part of the prompt emission in the keV-MeV range. The origin of precursors is still unknown, and studies of precursors can probe the formation of the GRB central engine and/or the nature of the jets that produce the emission. We present a systematic search for precursor emission in LAT and GBM data, and the temporal and spectral properties and energetics of the population of GRBs with precursors.

  3. THE FERMI GBM GAMMA-RAY BURST SPECTRAL CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Adam; Burgess, J. Michael; Preece, Robert D.; Briggs, Michael S.; Guiriec, Sylvain; Connaughton, Valerie; Paciesas, William S.; Bhat, P. N.; Chaplin, Vandiver [Physics Department, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Van der Horst, Alexander J.; Meegan, Charles A. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Wilson-Hodge, Colleen A.; Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Von Kienlin, Andreas; Bissaldi, Elisabetta; Diehl, Roland; Foley, Suzanne [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, 1500 Perimeter Parkway, Huntsville, AL 35806 (United States); and others

    2012-03-01

    We present systematic spectral analyses of gamma-ray bursts (GRBs) detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  4. The Successful Synergy of Swift and Fermi/GBM in Magnetars

    Science.gov (United States)

    Kouveliotou, Chryssa

    2011-01-01

    The magnetar rate of discovery has increased dramatically in the last decade. Five sources were discovered in the last three years alone as a result of the very efficient synergy among three X- and .gamma-ray instruments on NASA satellites: the Swift/Burst Alert Telescope (BAT), the Fermi/Gamma ray Burst Monitor (GBM), and the Rossi X-Ray Timing Explorer; RXTE/Proportional Counter Array (PCA). To date, there are approx. 25 magnetar candidates, of which two are (one each) in the Large and Small Magellanic Cloud and the rest reside on the Galactic plane of our Milky Way. I will discuss here the main properties of the Magnetar Population and the common projects that can be achieved with the synergy of Swift and GBM.

  5. Searching for Unmodeled Sources Using the Earth Occultation Data from the Fermi GBM

    CERN Document Server

    Rodi, James; Cherry, Michael L; Camero-Arranz, Ascension; Finger, Mark H; Jenke, Peter; Wilson-Hodge, Colleen A; Chaplin, Vandiver

    2011-01-01

    Employing the 12 NaI detectors in the Fermi GBM, the Earth Occultation Technique (EOT) can be used to measure the fluxes of x-ray and gamma-ray sources. Each time a source passes behind the Earth (or emerges from behind the Earth), a step-like feature is produced in the detector count rate. With a predefined catalog of source positions, the times of the occultation steps can be calculated, the individual steps fit, and the fluxes derived. However, in order to find new sources and generate a complete catalog, a method is needed for generating an image of the sky. An imaging algorithm has been developed to generate all-sky images using the GBM data. Here we present imaging results from ~2.5 years of data in the 12-25 keV and 100-300 keV energy bands.

  6. The Fermi GBM Gamma-Ray Burst Spectral Catalog: The First Two Years

    CERN Document Server

    Goldstein, Adam; Preece, Robert D; Briggs, Michael S; Guiriec, Sylvain; van der Horst, Alexander J; Connaughton, Valerie; Wilson-Hodge, Colleen A; Paciesas, William S; Meegan, Charles A; von Kienlin, Andreas; Bhat, P Narayana; Bissaldi, Elisabetta; Chaplin, Vandiver; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Greiner, Jochen; Gruber, David; Kippen, R Marc; Kouveliotou, Chryssa; McBreen, Sheila; McGlynn, Sinead; Rau, Arne; Tierney, Dave

    2012-01-01

    We present systematic spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  7. Background estimation in a wide-field background-limited instrument such as Fermi GBM

    CERN Document Server

    Fitzpatrick, Gerard; Connaughton, Valerie; Briggs, Michael

    2012-01-01

    The supporting instrument on board the Fermi Gamma-ray Space Telescope, the Gamma-ray Burst Monitor (GBM) is a wide-field gamma-ray monitor composed of 14 individual scintillation detectors, with a field of view which encompasses the entire unocculted sky. Primarily designed as transient monitors, the conventional method for background determination with GBM-like instruments is to time interpolate intervals before and after the source as a polynomial. This is generally sufficient for sharp impulsive phenomena such as Gamma-Ray Bursts (GRBs) which are characterised by impulsive peaks with sharp rises, often highly structured, and easily distinguishable against instrumental backgrounds. However, smoother long lived emission, such as observed in solar flares and some GRBs, would be difficult to detect in a background-limited instrument using this method. We present here a description of a technique which uses the rates from adjacent days when the satellite has approximately the same geographical footprint to dis...

  8. The Synergy between the LAT and GBM in GLAST's Study of Gamma-Ray Bursts

    Science.gov (United States)

    Band, David L.

    2007-01-01

    Using semi-analytic calculations I characterize the gamma-ray bursts to which GLAST's LAT and GBM detectors will be sensitive. The thresholds of both instruments are at approximately the same vfv proportional to E(sup 2)N(E) values, i.e., the thresholds can be connected by an E(sup -2) spectrum. Therefore simultaneous detections by both instruments will be biased towards spectral components flatter than E(sup -2).

  9. The Synergy between the LAT and GBM in GLAST's Study of Gamma-Ray Bursts

    International Nuclear Information System (INIS)

    Using semi-analytic calculations I characterize the gamma-ray bursts to which GLAST's LAT and GBM detectors will be sensitive. The thresholds of both instruments are at approximately the same νfν ∝ E2N(E) values, i.e., the thresholds can be connected by an E-2 spectrum. Therefore simultaneous detections by both instruments will be biased towards spectral components flatter than E-2

  10. NT-25EARLY JAPANESE EXPERIENCE WITH NovoTTF-100A SYSTEM FOR RECURRENT GBM

    OpenAIRE

    Muragaki, Yoshihiro; Nitta, Masayuki; Okumura, Tatsunori; Tabei, Yusuke; MARUYAMA, Takashi; Kaneko, Sadao; Suzuki, Ichiro

    2014-01-01

    BACKGROUND: NovoTTF-100A System is an FDA-approved treatment for recurrent glioblastoma (GBM) and is defined as a device of high unmet medical need in Japan. Subsequently, the device has been made available on a restricted case basis for compassionate use in Japan. Here we report initial experience with 10 patients treated at Tokyo Women's Medical University, Kashiwaba Neurosurgical Hospital and Japanese Red Cross Medical Center. METHODS: Using retrospective chart review, we analyzed patient ...

  11. The Fermi–GBM Three-year X-Ray Burst Catalog

    Science.gov (United States)

    Jenke, P. A.; Linares, M.; Connaughton, V.; Beklen, E.; Camero-Arranz, A.; Finger, M. H.; Wilson-Hodge, C. A.

    2016-08-01

    The Fermi Gamma-ray Burst Monitor (GBM) is an all-sky gamma-ray monitor well known in the gamma-ray burst (GRB) community. Although GBM excels in detecting the hard, bright extragalactic GRBs, its sensitivity above 8 keV and its all-sky view make it an excellent instrument for the detection of rare, short-lived Galactic transients. In 2010 March, we initiated a systematic search for transients using GBM data. We conclude this phase of the search by presenting a three-year catalog of 1084 X-ray bursts. Using spectral analysis, location, and spatial distributions we classified the 1084 events into 752 thermonuclear X-ray bursts, 267 transient events from accretion flares and X-ray pulses, and 65 untriggered gamma-ray bursts. All thermonuclear bursts have peak blackbody temperatures broadly consistent with photospheric radius expansion (PRE) bursts. We find an average rate of 1.4 PRE bursts per day, integrated over all Galactic bursters within about 10 kpc. These include 33 and 10 bursts from the ultra-compact X-ray binaries 4U 0614+09 and 2S 0918-549, respectively. We discuss these recurrence times and estimate the total mass ejected by PRE bursts in our Galaxy.

  12. The Interplanetary Network Supplement to the Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    CERN Document Server

    Hurley, K; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Svinkin, D S; Briggs, M S; Connaughton, V; Meegan, C; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; von Kienlin, A; Zhang, X; Yamaoka, K; Fukazawa, Y; Hanabata, Y; Ohno, M; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; Del Monte, E; Feroci, M; Marisaldi, M

    2013-01-01

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 393 were observed by at least one other instrument in the 9-spacecraft IPN. Of the 393, the localizations of 146 could be improved by arrival time analysis (or "triangulation"). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.4 arcminutes and 32 degrees, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1 sigma GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 degree systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If ...

  13. Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis.

    Science.gov (United States)

    Borza, Dorin-Bogdan

    2007-01-01

    Anti-glomerular basement membrane (anti-GBM) antibodies elicited by autoimmune or alloimmune mechanisms are associated with aggressive forms of rapid progressive glomerulonephritis. Pathogenic anti-GBM autoantibodies and alloantibodies target the noncollagenous (NC1) domains of the alpha3alpha4alpha5(IV) collagen, a major GBM component. In autoimmune anti-GBM glomerulonephritis, a breakdown of immune self-tolerance leads to the activation of autoreactive B and T cells recognizing epitopes within the alpha3NC1 subunit. In the GBM, the conformational epitopes targeted by anti-GBM autoantibodies are structurally sequestered within the alpha3alpha4alpha5NC1 hexamer complex formed upon assembly of collagen IV chains into trimeric molecules and networks. Autoantibodies selectively bind to and dissociate a subset of alpha3alpha4alpha5NC1 hexamers composed of monomer subunits, whereas hexamers containing NC1 dimer subunits are resistant to dissociation by autoantibodies. The crypticity of alpha3NC1 autoepitopes suggests that self-tolerance to alpha3(IV) collagen is broken by structural alterations of the native alpha3alpha4alpha5NC1 hexamer that unmask normally sequestered epitopes, triggering an autoimmune reaction. Post-transplant anti-GBM nephritis in the renal allograft of transplanted Alport patients is mediated by an alloimmune reaction to the NC1 domains of alpha3alpha4alpha5(IV) collagen, present in the allograft GBM but absent from Alport basement membranes. Alloantibodies from patients with autosomal-recessive Alport syndrome predominantly bind to the alpha3NC1 domain, whereas alloantibodies from X-linked Alport patients target preferentially, though not exclusively, epitopes within the alpha5NC1 subunit. The accessibility of the alloantigenic sites within the alpha3alpha4alpha5NC1 hexamers, contrasting with the crypticity of autoantigenic sites, suggest that different molecular forms of alpha3alpha4alpha5(IV) collagen initiate the immunopathogenic responses in

  14. Antigenic heterogeneity of IgA anti-GBM disease: new renal targets of IgA autoantibodies.

    Science.gov (United States)

    Ho, Julie; Gibson, Ian W; Zacharias, James; Fervenza, Fernando; Colon, Selene; Borza, Dorin-Bogdan

    2008-10-01

    Anti-glomerular basement membrane (anti-GBM) disease is an aggressive form of glomerulonephritis, usually mediated by immunoglobulin G (IgG) autoantibodies to the noncollagenous (NC1) domain of alpha 3(IV) collagen. Less is known about the target antigen(s) in patients with atypical anti-GBM disease involving IgA autoantibodies. We report a new case of IgA anti-GBM disease in a patient with a history of proliferative lupus nephritis who presented with increasing creatinine levels, proteinuria, and hematuria, but no clinical or serological evidence of lupus recurrence. Renal biopsy showed focal and segmental necrotizing glomerulonephritis with strong linear capillary loop IgA staining by means of immunofluorescence. Serological test results were negative for IgG or IgA autoantibodies against the alpha 3NC1 domain. By means of immunoblotting, IgA from patient serum bound to 38- to 48-kd antigens collagenase-solubilized from human GBM, but not to purified NC1 domains of GBM collagen IV. The target of patient's IgA autoantibodies thus was identified as a novel GBM antigen, distinct from the alpha 3NC1 domain or other known targets of anti-GBM IgA autoantibodies. Clinical resolution was attained by means of conventional treatment with steroids and cyclophosphamide. The diversity of antigens recognized by anti-GBM IgA autoantibodies highlights the importance of renal biopsy for the reliable diagnosis of this rare condition because conventional serological immunoassays likely would yield false-negative results. PMID:18752876

  15. Management of cataract with macular oedema due to diabetes mellitus Type-II and hypertension with grid laser prior to surgery and intra-vitreal bevacizumab (avastin) peroperatively

    International Nuclear Information System (INIS)

    To study the visual outcome in patients subjected to cataract extraction with prior grid laser and intraoperative intravitreal bevacizumab injection. Methods: This prospective case series comprised of 38 patients subjected to phacoemulsification and in the bag intraocular lens implantation at Al-Noor Eye Hospital and Sindh Govt Lyari General Hospital Karachi from January 2007 to December 2008. All the patients had prior macular grid treatment and intra-operative injection of intra-vitreal Avastin. Diabetes mellitus duration, preoperative glycosylated haemoglobin (HbA1c) level and other systemic and local complications of diabetes were recorded. The patients were clinically assessed with bio microscopic examination preoperatively, and postoperatively on day 1, week 1, and in months 1, 2, 3 and 6 respectively. Visual acuity and state of macular oedema was clinically assessed and documented. Results: Out of thirty-eight patients, eighteen were males and 20 were females. Mean duration of diabetes was 9.92 +- 5.5 years (Range 4-16) while that of hypertension was 7.87 +- 3.66 years (Range = 2-15). HbA1c level was 8.36% +- 1.93% (range 6.3 - 12.3). Thirty-one (81.5%) patients had HbA1c level 8.0% or above indicating a poor control. At 6 months of follow up best corrected distant visual acuity of 6/6 to 6/9 was achieved in 23(60.5 %), 6/12 in 11(28.9%) and 6/24 in 4(10.5%) cases while best corrected near acuity of N/6 was achieved in 22(57.8%) N/8 in 12(31.4%) and N/12 in 4(10.5%) cases. At 6 months follow up visual acuity declined in two cases because of uncontrolled diabetes and hypertension. Conclusion: Cataract surgery in diabetic patients with macular oedema and hypertension has a good visual outcome if prior macular grid laser is performed and intra-vitreal anti VEGF is injected during surgery. (author)

  16. Significance of mast cell renal infiltration in patients with anti-GBM nephritis.

    Science.gov (United States)

    Wu, Xiao-Mei; Zhang, Yi-Yan; Zhang, Ming-Chao; Zhang, Li-Hua; Zeng, Cai-Hong; Liu, Zhi-Hong; Tang, Zheng

    2016-07-01

    To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs SCr 8.95 ± 3.66 vs. 4.75 ± 2.73 mg/dL, p < 0.001), urine retinol-binding protein (RBP 29.8 ± 13.9 vs. 15.7 ± 11.5 mg/dL, p = 0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7 ± 21.9 vs. 47.0 ± 33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268 mm(-2) vs. 180 mm(-2), p = 0.045) and CD68 (268 mm(-2) vs. 180 mm(-2), p = 0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes. PMID:27095326

  17. Outburst of Sax J2103.5+4545 detected by Fermi/GBM

    Science.gov (United States)

    Jenke, P.; Finger, M. H.; Wilson-Hodge, C. A.

    2016-04-01

    Pulsations from the transient Be/X-ray pulsar Sax J2103.5+4545 are currently being detected with Fermi/GBM. The pulsations were first detected in the data of April 3-4 at a frequency of 2.8607(7) mHz. The ephemeris used to determine the frequency is from Camero-Arranz et al. 2007, A & A, 473, 55. The Swift/BAT transient monitor is showing an increase in flux starting on April 1 reaching 92 +/- 9 mCrab (15-50 keV) on April 4. The last comparable outburst occurred in December 2014.

  18. Techniques for Targeted Fermi-GBM Follow-Up of Gravitational-Wave Events

    Science.gov (United States)

    Blackburn, L.; Camp, J.; Briggs, M. S.; Connaughton, V.; Jenke, P.; Christensen, N.; Veitch, J.

    2012-01-01

    The Advanced LIGO and Advanced Virgo ground-based gravitational-wave (GW) detectors are projected to come online 2015 2016, reaching a final sensitivity sufficient to observe dozens of binary neutron star mergers per year by 2018. We present a fully-automated, targeted search strategy for prompt gamma-ray counterparts in offline Fermi-GBM data. The multi-detector method makes use of a detailed model response of the instrument, and benefits from time and sky location information derived from the gravitational-wave signal.

  19. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years of Data

    OpenAIRE

    Gruber, D.; Goldstein, A.; Weller von Ahlefeld, V.; Bhat, N.P.; Bissaldi, E.; Briggs, M S; Byrne, D.; Cleveland, W.H.; Connaughton, V.; Diehl, R.; Fishman, G. J.; Fitzpatrick, G.; Foley, S.; Gibby, M.; Giles, M M

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All ...

  20. VizieR Online Data Catalog: The second Fermi/GBM GRB catalog (4yr) (von Kienlin+, 2014)

    Science.gov (United States)

    von Kienlin, A.; Meegan, C. A.; Paciesas, W. S.; Bhat, P. N.; Bissaldi, E.; Briggs, M. S.; Burgess, J. M.; Byrne, D.; Chaplin, V.; Cleveland, W.; Connaughton, V.; Collazzi, A. C.; Fitzpatrick, G.; Foley, S.; Gibby, M.; Giles, M.; Goldstein, A.; Greiner, J.; Gruber, D.; Guiriec, S.; van der Horst, A. J.; Kouveliotou, C.; Layden, E.; McBreen, S.; McGlynn, S.; Pelassa, V.; Preece, R. D.; Rau, A.; Tierney, D.; Wilson-Hodge, C. A.; Xiong, S.; Younes, G.; Yu, H.-F.

    2014-04-01

    The Fermi Gamma-ray Burst Monitor (GBM), the secondary instrument on board the Fermi Gamma-ray Space Telescope, launched on 2008 June 11, is now operating successfully in space since five years. The GBM instrument extends the energy range of the main instrument, the Large Area Telescope (LAT; 30MeV-300GeV) down to the soft gamma-ray and X-ray energy range (8keV-40MeV). In the first four years of operation since triggering was enabled on 2008 July 12, GBM has triggered 2126 times on a variety of transient events: 954 of these are classified as GRBs (in one case the same GRB triggered GBM twice). The location of a GRB is calculated by comparing the measured individual detector counting rates with a lookup table (LUT), containing a list of relative detector rates for a grid of simulated sky locations. The on-board and on-ground LUTs have resolutions of 5° and 1°, respectively. With this method the limiting accuracy is approximately 8° for on-board locations and approximately 4° for on-ground locations. A detailed investigation of the GBM location accuracy can be found in Connaughton, V., Briggs, M. S., & Goldstein, A. et al. 2014 (ApJS, submitted). (5 data files).

  1. First-year Results of Broadband Spectroscopy of the Brightest Fermi-GBM Gamma-Ray Bursts

    CERN Document Server

    Bissaldi, Elisabetta; Kouveliotou, Chryssa; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Gruber, David; Lichti, Giselher; Bhat, P N; Burgess, J Michael; Chaplin, Vandiver; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Guiriec, Sylvain; van der Horst, Alexander J; Kippen, Marc; Lin, Lin; McBreen, Sheila; Meegan, Charles A; Paciesas, William S; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen

    2011-01-01

    We present here our results of the temporal and spectral analysis of a sample of 52 bright and hard gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM) during its first year of operation (July 2008-July 2009). Our sample was selected from a total of 253 GBM GRBs based on each event peak count rate measured between 0.2 and 40MeV. The final sample comprised 34 long and 18 short GRBs. These numbers show that the GBM sample contains a much larger fraction of short GRBs, than the CGRO/BATSE data set, which we explain as the result of our (different) selection criteria and the improved GBM trigger algorithms, which favor collection of short, bright GRBs over BATSE. A first by-product of our selection methodology is the determination of a detection threshold from the GBM data alone, above which GRBs most likely will be detected in the MeV/GeV range with the Large Area Telescope (LAT) onboard Fermi. This predictor will be very useful for future multiwavelength GRB follow ups with ground and ...

  2. The effect of silver nanoparticles (AgNPs) on proliferation and apoptosis of in ovo cultured glioblastoma multiforme (GBM) cells

    Science.gov (United States)

    Urbańska, Kaja; Pająk, Beata; Orzechowski, Arkadiusz; Sokołowska, Justyna; Grodzik, Marta; Sawosz, Ewa; Szmidt, Maciej; Sysa, Paweł

    2015-03-01

    Recently, it has been shown that silver nanoparticles (AgNPs) provide a unique approach to the treatment of tumors, especially those of neuroepithelial origin. Thus, the aim of this study was to evaluate the impact of AgNPs on proliferation and activation of the intrinsic apoptotic pathway of glioblastoma multiforme (GBM) cells cultured in an in ovo model. Human GBM cells, line U-87, were placed on chicken embryo chorioallantoic membrane. After 8 days, the tumors were divided into three groups: control (non-treated), treated with colloidal AgNPs (40 μg/ml), and placebo (tumors supplemented with vehicle only). At the end of the experiment, all tumors were isolated. Assessment of cell proliferation and cell apoptosis was estimated by histological, immunohistochemical, and Western blot analyses. The results show that AgNPs can influence GBM growth. AgNPs inhibit proliferation of GBM cells and seem to have proapoptotic properties. Although there were statistically significant differences between control and AgNP groups in the AI and the levels of active caspase 9 and active caspase 3, the level of these proteins in GBM cells treated with AgNPs seems to be on the border between the spontaneous apoptosis and the induced. Our results indicate that the antiproliferative properties of silver nanoparticles overwhelm proapoptotic ones. Further research focused on the cytotoxic effect of AgNPs on tumor and normal cells should be conducted.

  3. Improved Limits on Sterile Neutrino Dark Matter using Full-Sky Fermi-GBM Data

    CERN Document Server

    Ng, Kenny C Y; Gaskins, Jennifer M; Smith, Miles; Preece, Robert

    2015-01-01

    A sterile neutrino of ~keV mass is a well motivated dark matter candidate. Its decay generates a X-ray line which offers a unique target for X-ray telescopes. For the first time, we use the Gamma-ray Burst Monitor (GBM) onboard the Fermi Gamma-Ray Space Telescope to search for sterile neutrino decay lines; our analysis covers the energy range 10-25 keV (sterile neutrino mass 20-50 keV), which is inaccessible to X-ray and gamma-ray satellites such as Chandra, Suzaku, XMM-Newton, and INTEGRAL. The extremely wide field of view of the GBM enables a large fraction of the Milky Way dark matter halo to be probed. After implementing careful data cuts, we obtain ~53 days of full sky observational data. We search for sterile neutrino decay lines in the energy spectrum, and find no significant signal. From this, we obtain upper limits on the sterile neutrino mixing angle as a function of mass. In the sterile neutrino mass range 25-40 keV, we improve upon previous upper limits by approximately an order of magnitude. Bett...

  4. Magnetar Twists: Fermi/Gamma ray Burst Monitor (GBM) detection of SGR 1550-5418

    CERN Document Server

    Kaneko, Y; Kouveliotou, C; Ramirez-Ruiz, E; Granot, J; van der Horst, A J; Watts, A L; Finger, M H; Gehrels, N; Pe'er, A; van der Klis, M; von Kienlin, A; Wachter, S; Wilson-Hodge, C A; Woods, P M

    2009-01-01

    SGR 1550-5418 (previously known as AXP 1E 1547.0-5408) went into three active bursting episodes in 2008 October and in 2009 January and March, emitting hundreds of typical Soft Gamma Repeater (SGR) bursts in soft gamma rays. The second episode was especially intense, and our untriggered burst search on Fermi/GBM data (8-1000 keV) revealed ~450 bursts emitted over 24 hours during the peak of this activity. Using the GBM data, we identified a ~150-s-long enhanced persistent emission during 2009 January 22 that exhibited intriguing timing and spectral properties: (i) clear pulsations up to ~110 keV at the spin period of the neutron star (P ~2.07 s, the fastest of all magnetars), (ii) an additional (to a power-law) blackbody component required for the enhanced emission spectra with kT ~17 keV, (iii) pulsed fraction that is strongly energy dependent and highest in the 50-74 keV energy band. A total isotropic-equivalent energy emitted during this enhanced emission is estimated to be 4.3 x 10^{40} ergs. We conclude ...

  5. $Fermi$ GBM Observations of V404 Cyg During its 2015 Outburst

    CERN Document Server

    Jenke, P A; Homan, Jeroen; Veres, P; Briggs, M S; Burns, E; Connaughton, V; Finger, M H; Hui, M

    2016-01-01

    V404 Cygni was discovered in 1989 by the $Ginga$ X-ray satellite during its only previously observed X-ray outburst and soon after confirmed as a black hole binary. On June 15, 2015, the Gamma Ray Burst Monitor (GBM) triggered on a new outburst of V404 Cygni. We present 13 days of GBM observations of this latest outburst including Earth occultation flux measurements, spectral and temporal analysis. The Earth occultation fluxes reached 30 Crab with detected emission to 100 keV and determined, via hardness ratios, that the source was in a hard state. At high luminosity, spectral analysis between 8 and 300 keV showed that the electron temperature decreased with increasing luminosity. This is expected if the protons and electrons are in thermal equilibrium during an outburst with the electrons cooled by the Compton scattering of softer seed photons from the disk. However, the implied seed photon temperatures are unusually high, suggesting a contribution from another source, such as the jet. No evidence of state t...

  6. Tumour Relapse Prediction Using Multiparametric MR Data Recorded during Follow-Up of GBM Patients

    Directory of Open Access Journals (Sweden)

    Adrian Ion-Margineanu

    2015-01-01

    Full Text Available Purpose. We have focused on finding a classifier that best discriminates between tumour progression and regression based on multiparametric MR data retrieved from follow-up GBM patients. Materials and Methods. Multiparametric MR data consisting of conventional and advanced MRI (perfusion, diffusion, and spectroscopy were acquired from 29 GBM patients treated with adjuvant therapy after surgery over a period of several months. A 27-feature vector was built for each time point, although not all features could be obtained at all time points due to missing data or quality issues. We tested classifiers using LOPO method on complete and imputed data. We measure the performance by computing BER for each time point and wBER for all time points. Results. If we train random forests, LogitBoost, or RobustBoost on data with complete features, we can differentiate between tumour progression and regression with 100% accuracy, one time point (i.e., about 1 month earlier than the date when doctors had put a label (progressive or responsive according to established radiological criteria. We obtain the same result when training the same classifiers solely on complete perfusion data. Conclusions. Our findings suggest that ensemble classifiers (i.e., random forests and boost classifiers show promising results in predicting tumour progression earlier than established radiological criteria and should be further investigated.

  7. Gravitational wave observations may constrain gamma-ray burst models: the case of GW 150914 - GBM

    CERN Document Server

    Veres, P; Goldstein, A; Mészáros, P; Burns, E; Connaughton, V

    2016-01-01

    The possible short gamma-ray burst (GRB) observed by {\\it Fermi}/GBM in coincidence with the first gravitational wave (GW) detection, offers new ways to test GRB prompt emission models. Gravitational wave observations provide previously unaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW~150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density ($\\sim 10^{-3}$ cm$^{-3}$) and a high Lorentz factor ($\\sim 2000$). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Bl...

  8. VizieR Online Data Catalog: The five year Fermi/GBM magnetar burst catalog (Collazzi+, 2015)

    Science.gov (United States)

    Collazzi, A. C.; Kouveliotou, C.; van den Horst, A. J.; Younes, G. A.; Kaneko, Y.; Gogus, E.; Lin, L.; Granot, J.; Finger, M. H.; Chaplin, V. L.; Huppenkothen, D.; Watts, A. L.; Kienlin, A. V.; Baring, M. G.; Gruber, D.; Bhat, P. N.; Gibby, M. H.; Gehrels, N.; McEnery, J.; van der Klis, M.; Wijers, R. A. M. J.

    2015-07-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7. (3 data files).

  9. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    International Nuclear Information System (INIS)

    Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type) or highly diffuse single tumor cell infiltration (HD-type). We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM). Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  10. The Problem with Briefs, in Brief

    Science.gov (United States)

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  11. Circulating gamma delta T cells are activated and depleted during progression of high-grade gliomas: Implications for gamma delta T cell therapy of GBM

    Science.gov (United States)

    Glioblastoma multiforme (GBM) remains frustratingly impervious to any existing therapy. We have previously shown that GBM is sensitive to recognition and lysis by ex vivo activated gamma delta T cells, a minor subset of lymphocytes that innately recognize autologous stress-associated target antigens...

  12. Swift/BAT and Fermi/GBM observations of SGR J1935+2154 bursts

    Science.gov (United States)

    Lin, Lin

    2016-07-01

    SGR J1935+2154 is a new member of the magnetar family. It was discovered from a short burst which triggered Swift/BAT on 2014 July 5. In 2015 February, the source was detected in the burst active episode again which lasted for about 11 days. We searched for magnetar burst using Bayesian Blocks method through Swift/BAT and Fermi/GBM observations, and totally found 27 events including 3 in 2014 and 24 in 2015. In this talk we will present the result of our detailed analysis of the temporal and spectral properties of these short bursts, and briefly discuss the connection between burst activity and the persistent emission of the source.

  13. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    CERN Document Server

    Racusin, J L; Goldstein, A; Connaughton, V; Wilson-Hodge, C A; Jenke, P; Blackburn, L; Briggs, M S; Broida, J; Camp, J; Christensen, N; Hui, C M; Littenberg, T; Shawhan, P; Singer, L; Veitch, J; Bhat, P N; Cleveland, W; Fitzpatrick, G; Gibby, M H; von Kienlin, A; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O J; Stanbro, M; Veres, P; Zhang, B -B; Ackermann, M; Albert, A; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Bruel, P; Buson, S; Caliandro, G A; Cameron, R A; Caputo, R; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Charles, E; Chiang, J; Ciprini, S; Costanza, F; Cuoco, A; Cutini, S; D'Ammando, F; de Palma, F; Desiante, R; Digel, S W; Di Lalla, N; Di Mauro, M; Di Venere, L; Drell, P S; Favuzzi, C; Ferrara, E C; Focke, W B; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Gill, R; Giroletti, M; Glanzman, T; Granot, J; Green, D; Grove, J E; Guillemot, L; Guiriec, S; Harding, A K; Jogler, T; Johannesson, G; Kamae, T; Kensei, S; Kocevski, D; Kuss, M; Larsson, S; Latronico, L; Li, J; Longo, F; Loparco, F; Lubrano, P; Magill, J D; Maldera, S; Malyshev, D; McEnery, J E; Michelson, P F; Mizuno, T; Morselli, A; Moskalenko, I V; Negro, M; Nuss, E; Omodei, N; Orienti, M; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Principe, G; Raino, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Parkinson, P M Saz; Scargle, J D; Sgro, C; Simone, D; Siskind, E J; Smith, D A; Spada, F; Spinelli, P; Suson, D J; Tajima, H; Thayer, J B; Torres, D F; Troja, E; Uchiyama, Y; Vianello, G; Wood, K S; Wood, M

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, dif- ferences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  14. CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI

    Directory of Open Access Journals (Sweden)

    Matthew S. Brown

    2009-11-01

    Full Text Available The goal of this study was to develop a computer-aided therapeutic response (CADrx system for early prediction of drug treatment response for glioblastoma multiforme (GBM brain tumors with diffusion weighted (DW MR images. In conventional Macdonald assessment, tumor response is assessed nine weeks or more post-treatment. However, we will investigate the ability of DW-MRI to assess response earlier, at five weeks post treatment. The apparent diffusion coefficient (ADC map, calculated from DW images, has been shown to reveal changes in the tumor’s microenvironment preceding morphologic tumor changes. ADC values in treated brain tumors could theoretically both increase due to the cell kill (and thus reduced cell density and decrease due to inhibition of edema. In this study, we investigated the effectiveness of features that quantify changes from pre- and post-treatment tumor ADC histograms to detect treatment response. There are three parts to this study: first, tumor regions were segmented on T1w contrast enhanced images by Otsu’s thresholding method, and mapped from T1w images onto ADC images by a 3D region of interest (ROI mapping tool using DICOM header information; second, ADC histograms of the tumor region were extracted from both pre- and five weeks post-treatment scans, and fitted by a two-component Gaussian mixture model (GMM. The GMM features as well as standard histogram-based features were extracted. Finally, supervised machine learning techniques were applied for classification of responders or non-responders. The approach was evaluated with a dataset of 85 patients with GBM under chemotherapy, in which 39 responded and 46 did not, based on tumor volume reduction. We compared adaBoost, random forest and support vector machine classification algorithms, using ten-fold cross validation, resulting in the best accuracy of 69.41% and the corresponding area under the curve (Az of 0.70.

  15. TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

    International Nuclear Information System (INIS)

    Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the direct effects of TLR9 agonist CpG ODN upon the proliferation and invasion of glioma cells in vitro. RT-PCR and immunofluorescence were used to determine the expression of TLR9 in glioma cell lines and clinical glioma samples. Tissue microarry and immunohistochemistry were applied to evaluated TLR9 expression in 292 newly diagnosed glioma and 13 non-neoplastic brain tissues. We further investigated the effect of CpG ODN on the proliferation and invasion of glioma cells in vitro with MTT assays and matrigel transwell assay respectively. RT-PCR showed that TLR9 expressed in all the glioma samples and glioma cell lines we examined. The tissue array analysis indicated that TLR9 expression is correlated with malignancy of glioma (p < 0.01). Multivariate Cox regression analysis revealed that TLR9 expression is an independent prognostic factor for PFS of GBM patients(P = 0.026). TLR9 agonist CpG ODN has no significant effect on glioma proliferation, but matrigel transwell analysis showed that TLR9 agonist CpG ODN can significantly enhance glioma invasion in vitro. Our data indicated that TLR9 expression increases according to the histopathological grade of glioma, and the TLR9 expression level is related to the PFS of GBM patients. In addition, our findings warrant caution in the directly injection of TLR9 agonist CpG ODN into glioma tissues for the glioma immunotherapy

  16. Detection of Pulsed Hard X-ray Emission from 4U 0142+61 with Fermi/GBM

    Science.gov (United States)

    Gogus, Ersin; Younes, George; Kouveliotou, Chryssa

    2015-03-01

    As part of our effort to monitor pulsed hard X-ray emission from magnetars with Fermi/GBM, we searched continuously recorded daily data (CTIME, 0.256 s time resolution) of 4U 0142+61 collected on March 1, 2015, soon after the onset of its latest activation (GCN #17507).

  17. Duration Distribution of Fermi/GBM Gamma-Ray Bursts: Instrumental Selection Effect of the Bimodal T90 Distribution

    CERN Document Server

    Qin, Ying; Yi, Shuang-Xi; Liang, Yun-Feng; Lin, Lin; Zhang, Bin-Bin; Zhang, Jin; Lu, Hou-Jun; Lu, Rui-Jing; Lu, Lian-Zhong; Zhang, Bing

    2012-01-01

    The durations (T_{90}) of 315 Fermi GRBs detected with the GBM-NaI detectors (8-1000 KeV) by 2011 September are calculated using the Bayesian Block method. We compare the T_{90} distribution of the GBM-NaI sample to that observed with CGRO/BATSE (25-2000 keV), BeppoSAX/GRBM (40-700 KeV), HETE-2/FREGATE (6-80 keV), and Swift/BAT (15-150 keV). We show that the T_{90} distribution of the GBM-NaI GRB sample is bimodal, with a statistical significance level being comparable to that observed with BeppoSAX/GRBM and Swift/BAT but much lower than that observed with CGRO/BATSE. No bimodal T_{90} distribution is found in the HETE-2 GRB sample. Taking T_{90}=2 seconds as the division line between long and short GRBs, the ratio of short to long GRB numbers are 0:95, 51:557, 111:892, 39:253, and 500:1541 for the HETE-2/FREGATE, Swift/BAT, BeppoSAX/GRBM, GBM-NaI, and CGRO/BATSE GRB samples, respectively. These results suggest that the bimodal T_{90} distribution would be due to an instrumental selection effect. We investiga...

  18. ET-54 immunotherapy based on tumor transplant antigen recognition emerges as a promising strategy for recurrent glioblastoma multiform (GBM) patients

    NARCIS (Netherlands)

    Schijns, V.E.J.C.; Pretto, C.; Devillers, L.; Pierre, D.; Hofman, F.

    2014-01-01

    Glioblastoma multiforme (GBM) prognosis remains very poor. This is especially true when the tumors relapse on the current standard of care treatments. Our preclinical data, generated in a rat CNS-1 glioma model in Lewis rats, provided the scientific rationale for a prototype clinical vaccine prepara

  19. Avastin联合黄斑格栅样光凝治疗糖尿病黄斑水肿观察%Clinical investigation of intravitreal Avastin and macular grid photocoagulation for diabetic macular edema

    Institute of Scientific and Technical Information of China (English)

    胡忆群; 陈青山; 方敏; 佘洁婷; 杨旭

    2012-01-01

    Objective To investigate the effects of intravitreal Avastin combined with macular grid photocoagulation (MGP) for diabetic macular edema (DME).Methods Fouty-five DME patients (59eyes) were divided into two groups randomly,26 eyes received MGP (MGP Group) and 33 eyes received intravitreal injection of 1.5 mg Avastin followed by MGP (combined Group).All eyes underwent a complete ophthalmic examination including BCVA,IOP,and OCT at baseline and 1,3,6months after treatment.The outcome measures were the changes compared with baseline in BCVA,changes in CMT.Dates were analyzed using the paired t-test and one-way ANOVA (SPSS 13.0).The BCVA levels were converted to logMAR equivalents and analyzed.P < 0.05 was considered statistically significant.Results After treatment,the improvement in CMT in the MGP group was significant,yet there was no significant improvement in the mean BCVA (logMAR).The improvement in mean CMT was significant at 1,3,6 month (P < 0.01),with corresponding improvement in the combined group.The BCVA did not deteriorate below baseline in all eyes included in the study,except two eyes in the MGP group.No complication related to the intravitreal injection occurred.Conclusions.Combination treatment with intravitreal Avastin and macular grid photocoagulation for DME is well tolerated,with a significantly improvement in BCVA and CMT.This suggests combination treatment with intravitreal Avastin and macular grid photocoagulation for diabetic merits further investigation.%目的 观察玻璃体腔注射Avastin联合黄斑格栅样光凝治疗糖尿病黄斑水肿的效果.方法 临床病例对照研究.对2010年5月至2011年5月在深圳市眼科医院就诊病人,将符合纳入标准并经眼底荧光造影(fundus fluorescein angiography,FFA)及相干光断层扫描(optical coherence tomography,OCT)确诊为糖尿病黄斑水肿(diabetic macular edema,DME)的患者45例59只眼,随机分为A、B二组,A组21例26只眼;B组24例33只眼.A组:单纯

  20. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    OpenAIRE

    Racusin, J. L.; Burns, E; Goldstein, A.; Connaughton, V.; C. A. Wilson-Hodge(NASA/Marshall Space Flight Center, Huntsville, United States); Jenke, P.; Blackburn, L.; Briggs, M. S.; Broida, J.; Camp, J.; Christensen, N.; Hui, C. M.; Littenberg, T.; Shawhan, P.; Singer, L.

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GB...

  1. Time delays between Fermi LAT and GBM light curves of GRBs

    CERN Document Server

    Castignani, Gianluca; Pian, Elena; Amati, Lorenzo; Puccetti, Simonetta; Dichiara, Simone

    2014-01-01

    Most Gamma-Ray Bursts (GRBs) detected by the Fermi Gamma-ray Space Telescope exhibit a delay of up to about 10 seconds between the trigger time of the hard X-ray signal as measured by the Fermi GBM and the onset of the MeV-GeV counterpart detected by the LAT. This delay may hint at important physics, whether it is due to the intrinsic variability of the inner engine or it is related to quantum dispersion effects in the velocity of light propagation from the sources to the observer. It is critical to have a proper assessment of how these time delays affect the overall properties of the light curves. We cross-correlated the 5 brightest GRBs of the 1st Fermi LAT Catalog by means of the continuous correlation function (CCF) and of the Discrete Correlation Function (DCF). A maximum in the DCF suggests the presence of a time lag between the curves, whose value and uncertainty are estimated through a Gaussian fitting of the DCF profile and light curve simulation via a Monte Carlo approach. The cross-correlation of t...

  2. GBM Monitoring of Cyg X-1 During the Recent State Transition

    CERN Document Server

    Case, G L; Cherry, M L; Camero-Arranz, A; Finger, M; Jenke, P; Wilson-Hodge, C A; Chaplin, V

    2011-01-01

    Cygnus X-1 is a high-mass x-ray binary with a black hole compact object. It is normally extremely bright in hard x-rays and low energy gamma rays and resides in the canonical hard spectral state. Recently, however, Cyg X-1 made a transition to the canonical soft state, with a rise in the soft x-ray flux and a decrease in the flux in the hard x-ray and low energy gamma-ray energy bands. We have been using the Gamma-Ray Burst Monitor on Fermi to monitor the fluxes of a number of sources in the 8--1000 keV energy range, including Cyg X-1. We present light curves of Cyg X-1 showing the flux decrease in hard x-ray and low energy gamma-ray energy bands during the state transition as well as the several long flares observed in these higher energies during the soft state. We also present preliminary spectra from GBM for the pre-transition state, showing the spectral evolution to the soft state, and the post-transition state.

  3. Restriction spectrum imaging of bevacizumab-related necrosis in a patient with GBM

    Directory of Open Access Journals (Sweden)

    Nikdokht eFarid

    2013-09-01

    Full Text Available Importance:With the increasing use of antiangiogenic agents in the treatment of high grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with histopathologic validation, confirming that this region of restricted diffusion represents necrosis and not viable tumor. Observations:We present a case report of a 52-year-old man with GBM treated with temozolomide, radiation, and concurrent bevacizumab following gross total resection. The patient underwent sequential MRI's which included restriction-spectrum imaging (RSI, an advanced diffusion-weighted imaging (DWI technique, and MR perfusion. Following surgery, the patient developed an area of restricted diffusion on RSI which became larger and more confluent over the next several months. Marked signal intensity on RSI and very low cerebral blood volume (CBV on MR perfusion led us to favor bevacizumab-related necrosis over recurrent tumor. Subsequent histopathologic evaluation confirmed coagulative necrosis.Conclusions and Relevance:Our report increases the number of pathologically-proven cases of bevacizumab-related necrosis in the literature from three to four. Furthermore, our case demonstrates this phenomenon on RSI, which has been shown to have good sensitivity to restricted diffusion.

  4. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

    CERN Document Server

    Gruber, David; von Ahlefeld, Victoria Weller; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Byrne, Dave; Cleveland, William H; Connaughton, Valerie; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty M; Greiner, Jochen; Guiriec, Sylvain; van der Horst, Alexander J; von Kienlin, Andreas; Kouveliotou, Chryssa; Layden, Emily; Lin, Lin; Meegan, Charles A; McGlynn, Sinéad; Paciesas, William S; Pelassa, Véronique; Preece, Robert D; Rau, Arne; Wilson-Hodge, Colleen A; Xiong, Shaolin; Yu, Hoi-Fung

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  5. Testing the anisotropy in the angular distribution of $Fermi$/GBM gamma-ray bursts

    CERN Document Server

    Tarnopolski, Mariusz

    2015-01-01

    Gamma-ray bursts (GRBs) were confirmed to be of extragalactic origin due to their isotropic angular distribution, combined with the fact that they exhibited an intensity distribution that deviated strongly from the $-3/2$ power law. This finding was later confirmed with the first redshift, equal to at least $z=0.835$, measured for GRB970508. Despite this result, the data from $CGRO$/BATSE and $Swift$/BAT indicate that long GRBs are indeed distributed isotropically, but the distribution of short GRBs is anisotropic. $Fermi$/GBM has detected 1669 GRBs up to date, and their sky distribution is examined in this paper. A number of statistical tests is applied: nearest neighbour analysis, fractal dimension, dipole and quadrupole moments of the distribution function decomposed into spherical harmonics, binomial test, and the two point angular correlation function. Monte Carlo benchmark testing of each test is performed in order to evaluate its reliability. It is found that short GRBs are distributed anisotropically ...

  6. The optical identification of events with poorly defined locations: the case of the Fermi GBM GRB 140801A

    Science.gov (United States)

    Lipunov, V. M.; Gorosabel, J.; Pruzhinskaya, M. V.; Postigo, A. de Ugarte; Pelassa, V.; Tsvetkova, A. E.; Sokolov, I. V.; Kann, D. A.; Xu, Dong; Gorbovskoy, E. S.; Krushinski, V. V.; Kornilov, V. G.; Balanutsa, P. V.; Boronina, S. V.; Budnev, N. M.; Cano, Z.; Castro-Tirado, A. J.; Chazov, V. V.; Connaughton, V.; Delvaux, C.; Frederiks, D. D.; Fynbo, J. F. U.; Gabovich, A. V.; Goldstein, A.; Greiner, J.; Gress, O. A.; Ivanov, K. I.; Jakobsson, P.; Klose, S.; Knust, F.; Komarova, V. N.; Konstantinov, E.; Krylov, A. V.; Kuvshinov, D. A.; Kuznetsov, A. S.; Lipunova, G. V.; Moskvitin, A. S.; Pal'shin, V. D.; Pandey, S. B.; Poleshchuk, V. A.; Schmidl, S.; Sergienko, Yu. P.; Sinyakov, E. V.; Schulze, S.; Sokolov, V. V.; Sokolova, T. N.; Sparre, M.; Thöne, C. C.; Tlatov, A. G.; Tyurina, N. V.; Ulanov, M. V.; Yazev, S. A.; Yurkov, V. V.

    2016-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg2 3-σ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically reacts to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 s after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m Big Telescope Alt-azimuth of the Special Astrophysical Observatory of the Russian Academy of Sciences reveals a redshift of z = 1.32. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4 to 10.4 m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst are E_iso = 5.54_{-0.24}^{+0.26} {×} 10^{52} erg and Ep, rest ≃ 280 keV, respectively, which is consistent with the Amati relation. The absence of a jet break in the optical light curve provides a lower limit on the half-opening angle of the jet θ = 6.1°. The observed Epeak is consistent with the limit derived from the Ghirlanda relation. The joint Fermi GBM and Konus-Wind analysis show that GRB 140801A could belong to the class of intermediate duration. The rapid detection of the optical counterpart of GRB 140801A is especially important regarding the upcoming experiments with large coordinate error-box areas.

  7. FIRST-YEAR RESULTS OF BROADBAND SPECTROSCOPY OF THE BRIGHTEST FERMI-GBM GAMMA-RAY BURSTS

    International Nuclear Information System (INIS)

    We present our results of the temporal and spectral analysis of a sample of 52 bright and hard gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM) during its first year of operation (2008 July-2009 July).Our sample was selected from a total of 253 GBM GRBs based on the event peak count rate measured between 0.2 and 40 MeV. The final sample comprised of 34 long and 18 short GRBs. These numbers show that the GBM sample contains a much larger fraction of short GRBs than the CGRO/BATSE data set, which we explain as the result of our (different) selection criteria, which favor collection of short, bright GRBs over BATSE. A first by-product of our selection methodology is the determination of a detection threshold from the GBM data alone, above which GRBs most likely will be detected in the MeV/GeV range with the Large Area Telescope on board Fermi. This predictor will be very useful for future multi-wavelength GRB follow-ups with ground- and space-based observatories. Further, we have estimated the burst durations up to 10 MeV and for the first time expanded the duration-energy relationship in the GRB light curves to high energies. We confirm that GRB durations decline with energy as a power law with index approximately -0.4, as was found earlier with the BATSE data and we also notice evidence of a possible cutoff or break at higher energies. Finally, we performed time-integrated spectral analysis of all 52 bursts and compared their spectral parameters with those obtained with the larger data sample of the BATSE data. We find that the two parameter data sets are similar and confirm that short GRBs are in general harder than longer ones.

  8. ET-54IMMUNOTHERAPY BASED ON TUMOR TRANSPLANT ANTIGEN RECOGNITION EMERGES AS A PROMISING STRATEGY FOR RECURRENT GLIOBLASTOMA MULTIFORME (GBM) PATIENTS

    OpenAIRE

    Schijns, Virgil; Pretto, Chrystel; Devillers, Laurent; Pierre, Denis; Hofman, Florence; Kruse, Carol; Chen, Thomas; Oertel, Joachim; Hantos, Peter; Bota, Daniela; Stathopoulos, Apostolos

    2014-01-01

    Glioblastoma multiforme (GBM) prognosis remains very poor. This is especially true when the tumors relapse on the current standard of care treatments. Our preclinical data, generated in a rat CNS-1 glioma model in Lewis rats, provided the scientific rationale for a prototype clinical vaccine preparation, named ERC 1671 (Gliovac). ERC1671 is composed of autologous antigens, derived from the patient's own tumour tissue, and administered in conjunction with allogeneic antigens from histologicall...

  9. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    OpenAIRE

    Bente Sandvei Skeie; Jian Wang; Ernest Dodoo; Jan Ingeman Heggdal; Janne Grønli; Linda Sleire; Sidsel Bragstad; Ganz, Jeremy C.; Martha Chekenya; Sverre Mørk; Paal-Henning Pedersen; Per Øyvind Enger

    2013-01-01

    Object. Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs). However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS...

  10. Saponin 1 Induces Apoptosis and Suppresses NF-κB-Mediated Survival Signaling in Glioblastoma Multiforme (GBM)

    OpenAIRE

    Li, Juan; Tang, Haifeng; Zhang, Yun; Tang, Chi; Li, Bo; Wang, Yuangang; Gao, Zhenhui; Luo, Peng; Yin, Anan; Wang, Xiaoyang; Cheng, Guang; Fei, Zhou

    2013-01-01

    Saponin 1 is a triterpeniod saponin extracted from Anemone taipaiensis, a traditional Chinese medicine against rheumatism and phlebitis. It has also been shown to exhibit significant anti-tumor activity against human leukemia (HL-60 cells) and human hepatocellular carcinoma (Hep-G2 cells). Herein we investigated the effect of saponin 1 in human glioblastoma multiforme (GBM) U251MG and U87MG cells. Saponin 1 induced significant growth inhibition in both glioblastoma cell lines, with a 50% inhi...

  11. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients.

    Science.gov (United States)

    Raizer, J J; Giglio, P; Hu, J; Groves, M; Merrell, R; Conrad, C; Phuphanich, S; Puduvalli, V K; Loghin, M; Paleologos, N; Yuan, Y; Liu, D; Rademaker, A; Yung, W K; Vaillant, B; Rudnick, J; Chamberlain, M; Vick, N; Grimm, S; Tremont-Lukats, I W; De Groot, J; Aldape, K; Gilbert, M R

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29-75) and median KPS was 90 (70-100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2-47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  12. ET-66ER-STRESS INDUCING DRUGS SENSITIZES GBM TO TEMOZOLOMIDE THROUGH DOWNREGULATION OF MGMT AND INDUCTION OF REGULATED NECROSIS

    Science.gov (United States)

    Xipell, Enric; Martínez-Velez, Naiara; Vera-Cano, Beatriz; Idoate, Miguel Angel; Garzón, Antonia García; Acanda, Arlet M.; Fueyo, Juan; Gomez-Manzano, Candelaria; Alonso, Marta M

    2014-01-01

    Termozolamide (TMZ) is the standard treatment against GBM, unfortunately its therapeutic effect is limited due to the expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). Therefore, approaches that overcome the resistance to TMZ could be feasible therapeutic alternatives for this deadly disease. Endoplasmic reticulum (ER) stress suppresses several DNA damage proteins through the unfolding protein response. In this work we sought to evaluate whether ER-stress inducing drugs were able to downmodulate MGMT and sensitize GBM cells to TMZ treatment. Salinomycin (SLM) is a potassium ionophore that has proven effective against cancer stem cells and a possible candidate to induce ER stress. Our data showed that SLM triggered ER stress that was accompanied by the downregulation of MGMT. We obtained the same results with other ER stress inducing drugs (thapsigergin, tunicamycin) suggesting that this is a general mechanism. Chemical inhibition of ER stress reverted the abrogation of MGMT downregulation. Of importance, SLM induced an aberrant autophagic flux that led to regulated necrosis cell death mediated by the action of AIF protein, which induces DNA damage when localized in the nucleus. Combination of TMZ and SLM displayed a potent antitumor effect in vitro and in vivo in mice bearing a GBM stem cell model. Combination treatment induced a significant increase in DNA damage as shown by H2AX activation and PARP. Moreover, we observed AIF in the nucleus, as a result of the regulated necrosis, furthering favoring the DNA damage. Combination treatment showed an increment of the median survival and of long term survivors. Moreover tissue analysis confirmed a dramatic increase in the level of DNA damage. Altogether our results showed that combination treatment induces a potent antiglioma effect in vitro and in vivo. Our data uncover the possibility to exploit ER stress and regulated necrosis as therapeutic strategies for GBM treatment.

  13. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Wilson-Hodge, Colleen A; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Jenke, Peter; Chaplin, Vandiver; Beklen, Elif; Finger, Mark; Bhat, Narayan; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2012-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 102 sources, including 41 low-mass X-ray binary/neutron star systems, 33 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.

  14. Fermi/GBM observations of the ultra-long GRB 091024: A burst with an optical flash

    CERN Document Server

    Gruber, D; Foley, S; Nardini, M; Burlon, D; Rau, A; Bissaldi, E; von Kienlin, A; McBreen, S; Greiner, J; Bhat, P N; Briggs, M S; Burgess, J M; Chaplin, V L; Connaughton, V; Diehl, R; Fishman, G J; Gibby, M H; Giles, M M; Goldstein, A; Guiriec, S; van der Horst, A J; Kippen, R M; Kouveliotou, C; Lin, L; Meegan, C A; Paciesas, W S; Preece, R D; Tierney, D; Wilson-Hodge, C

    2011-01-01

    In this paper we examine gamma-ray and optical data of GRB 091024, a gamma-ray burst (GRB) with an extremely long duration of T90~1020 s, as observed with the Fermi Gamma-Ray Burst Monitor (GBM). We present spectral analysis of all three distinct emission episodes using data from Fermi/GBM. Because of the long nature of this event, many ground-based optical telescopes slewed to its location within a few minutes and thus were able to observe the GRB during its active period. We compare the optical and gamma-ray light curves. Furthermore, we estimate a lower limit on the bulk Lorentz factor from the variability and spectrum of the GBM light curve and compare it with that obtained from the peak time of the forward shock of the optical afterglow. From the spectral analysis we note that, despite its unusually long duration, this burst is similar to other long GRBs, i.e. there is spectral evolution (both the peak energy and the spectral index vary with time) and spectral lags are measured. We find that the optical ...

  15. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  16. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    Directory of Open Access Journals (Sweden)

    Bente Sandvei Skeie

    2013-01-01

    Full Text Available Object. Gamma knife surgery (GKS may be used for recurring glioblastomas (GBMs. However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment. Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test. Results. In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001. In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006. Polynuclear macrophages and fibrosis was seen in groups subjected to GKS. Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04. Conclusion. GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.

  17. Improved limits on sterile neutrino dark matter from full-sky observations by the Fermi-GBM

    CERN Document Server

    Horiuchi, Shunsaku; Gaskins, Jennifer M; Smith, Miles; Preece, Robert

    2015-01-01

    For the first time, we use the Gamma-ray Burst Monitor (GBM) on-board the Fermi satellite to search for sterile neutrino decay lines in the energy range 10-25 keV corresponding to sterile neutrino mass range 20-50 keV. This energy range has been out of reach of traditional X-ray satellites such as Chandra, Suzaku, XMM-Newton, and gamma-ray satellites such as INTEGRAL. Furthermore, the extremely wide field of view of the GBM opens a large fraction of the Milky Way dark matter halo to be probed. We start with 1601 days worth of GBM data, implement stringent data cuts, and perform two simple line search analyses on the reduced data: in the first, the line flux is limited without background modeling, and in the second, the background is modeled as a power-law. We find no significant excess lines in both our searches. We set new limits on sterile neutrino mixing angles, improving on previous limits by approximately an order of magnitude. Better understanding of detector and astrophysical backgrounds, as well as de...

  18. Prescribing Brief Psychotherapy

    OpenAIRE

    Schuyler, Dean

    2000-01-01

    Brief psychotherapy has demonstrated its effectiveness in treating emotional disorders and helping with problems that typically present to primary care physicians. Because practitioners receive little instruction about this treatment option and often have erroneous preconceived ideas about it, psychotherapy remains underprescribed. Effective brief therapy enables the patient to problem-solve, facilitates the relationship with the provider, and ultimately clarifies the patient's situation. Ref...

  19. P17.14A PROPOSAL OF A MODIFIED STUPP'S SCHEDULE WITH PROLONGED ADJUVANT TEMOZOLOMIDE: EXPERIENCE OF A SINGLE INSTITUTION IN A SERIES OF 100 CONSECUTIVE GBM PATIENTS

    OpenAIRE

    Caroli, M.; Minichiello, M.; Di Cristofori, A.; Lanfranchi, G; Bertani, G; Carrabba, G.; Rampini, P

    2014-01-01

    BACKGROUND: Glioblastoma (GBM) is a primary malignant brain tumor and its evolution is generally rapidly fatal. The current standard of care for this disease is surgical resection followed by concomitant radiationtherapy plus chemiotherapy as described by Stupp and Colleagues. In this study we described our experience in a series of 100 consecutive patients affected by GBM treated with modified Stupp regimen at “Fondazione IRCCS Ca' Granda Ospedale Policlinico Maggiore” in Milan, Italy. METHO...

  20. MIF-CD74 GUIDED THERAPEUTIC STRATEGY FOR THE UPFRONT TREATMENT OF GBM PATIENTS WITH AN UNMETHYLATED MGMT PROMOTER

    Science.gov (United States)

    McDonald, Kerrie L; Ha, Wendy; Sevim, Hatice

    2014-01-01

    BACKGROUND: Promoter methylation of the DNA repair gene, MGMT is associated with improved treatment outcome for newly diagnosed glioblastoma (GBM) treated with standard chemoradiation. Currently, there are no universally effective systemic treatments available for patients with an unmethylated MGMT promoter or treatments for patients whose tumor recurs after primary treatment, irrespective of MGMT methylation status. We used SELDI-TOF MS to identify low molecular weight proteins associated with poor survival. We report a new therapeutic strategy with potential to overcome the drug resistance conferred by MGMT when applied as an adjunct therapy to the standard chemoradiation for patients. METHODS: We screened the low molecular weight proteome of patients' tumors, which were non-responsive to chemoradiotherapy (survival <12 months). Proteins of significant abundance in the non-responsive patients were purified, identified and validated in a larger cohort of GBM (n = 230). Inhibitors were sourced and efficacy of the drug was tested in patient derived tumor models. RESULTS: High expression of the inflammatory related protein Macrophage Inhibitory Factor (MIF) and its receptor, CD74 were found in patients who were non-responsive to chemoradiation. Heightened expression of both MIF and CD74 were identified in 57% of GBM (n = 230) and co-segregated with poor prognosis. CD74 forms a complex with CD44 at the cell surface. After MIF binds to the CD74/44 complex, Src is recruited. Src recruitment then initiates the activation of multiple pathways including Ras/MAPK and Akt resulting in tumor proliferation. Pro-angiogenic effects have also been attributed to this complex. Because of its involvement in tumorigenesis, inhibition of the MIF/CD74/CD44 complex with specific inhibitors in combination with chemoradiotherapy will likely abate the resistance to standard treatment and result in longer survival. Ibudilast (AV411; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a] pyridine) is an

  1. A Novel GBM Saliency Detection Model Using Multi-Channel MRI.

    Directory of Open Access Journals (Sweden)

    Subhashis Banerjee

    Full Text Available The automatic computerized detection of regions of interest (ROI is an important step in the process of medical image processing and analysis. The reasons are many, and include an increasing amount of available medical imaging data, existence of inter-observer and inter-scanner variability, and to improve the accuracy in automatic detection in order to assist doctors in diagnosing faster and on time. A novel algorithm, based on visual saliency, is developed here for the identification of tumor regions from MR images of the brain. The GBM saliency detection model is designed by taking cue from the concept of visual saliency in natural scenes. A visually salient region is typically rare in an image, and contains highly discriminating information, with attention getting immediately focused upon it. Although color is typically considered as the most important feature in a bottom-up saliency detection model, we circumvent this issue in the inherently gray scale MR framework. We develop a novel pseudo-coloring scheme, based on the three MRI sequences, viz. FLAIR, T2 and T1C (contrast enhanced with Gadolinium. A bottom-up strategy, based on a new pseudo-color distance and spatial distance between image patches, is defined for highlighting the salient regions in the image. This multi-channel representation of the image and saliency detection model help in automatically and quickly isolating the tumor region, for subsequent delineation, as is necessary in medical diagnosis. The effectiveness of the proposed model is evaluated on MRI of 80 subjects from the BRATS database in terms of the saliency map values. Using ground truth of the tumor regions for both high- and low- grade gliomas, the results are compared with four highly referred saliency detection models from literature. In all cases the AUC scores from the ROC analysis are found to be more than 0.999 ± 0.001 over different tumor grades, sizes and positions.

  2. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

    Science.gov (United States)

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J.; Wasiluk, Andrew; Heidet, Laurence; Kitching, A. Richard; Borza, Dorin-Bogdan

    2012-01-01

    Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated with mild non-progressive glomerulonephritis, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoAbs were investigated in mouse models recapitulating this phenotype. Wild type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoAbs specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause glomerulonephritis. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG antibodies specific for α3α4α5NC1 hexamers, which were not subclass restricted. As heterologous antigen in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a and IgG2b autoAbs specific for α345NC1 hexamers and induced anti-GBM Ab glomerulonephritis. These findings indicate that tolerance toward autologous intact α3α4α5(IV) collagen is established in hosts expressing this antigen, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α3α4α5NC1 hexamers. This provides a mechanism eliciting autoAbs specific for α345NC1 hexamers, which are restricted to non-inflammatory IgG subclasses and non-nephritogenic. In Alport syndrome, lack of tolerance toward α3α4α5(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including pro-inflammatory IgG subclasses which mediate post-transplant anti-GBM nephritis. PMID:23303673

  3. Medicaid Issue Briefs

    Data.gov (United States)

    U.S. Department of Health & Human Services — MS, in collaboration with Mathematica, has started the MAX Medicaid policy issue brief series, which highlights the essential role MAX data can play in analyzing...

  4. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

    Directory of Open Access Journals (Sweden)

    Nameeta Shah

    Full Text Available O⁶-methylguanine DNA-methyltransferase (MGMT promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (CpG dinucleotide methylation across the entire MGMT promoter and to correlate individual CpG site methylation patterns to mRNA expression, protein expression, and progression-free survival. To best identify the specific MGMT promoter region most predictive of gene silencing and response to therapy, we determined the methylation status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients using quantitative bisulfite sequencing. We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival. Using this data, we propose a new classification scheme utilizing methylation data from across the entire promoter and show that an analysis based on this approach, which we call 3R classification, is predictive of progression-free survival (HR  = 5.23, 95% CI [2.089-13.097], p<0.0001. To adapt this approach to the clinical setting, we used a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA test based on the 3R classification and show that this test is both feasible in the clinical setting and predictive of progression free survival (HR  = 3.076, 95% CI [1.301-7.27], p = 0.007. We discuss the potential advantages of a test based on this promoter-wide analysis and compare it to the commonly used methylation-specific PCR test. Further prospective validation of these two methods in a large independent patient cohort will be needed to confirm the added value of promoter wide analysis of MGMT methylation in the clinical

  5. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide

    Science.gov (United States)

    CHEN, CHIEN-MIN; SYU, JHIH-PU; WAY, TZONG-DER; HUANG, LI-JIAU; KUO, SHENG-CHU; LIN, CHUNG-TIEN; LIN, CHIH-LI

    2015-01-01

    Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti-glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti-proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell-cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy-mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B-induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken together, the present results provide molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug-resistant glioblastoma cells to the chemotherapeutic agent TMZ. PMID:26329365

  6. Short Gamma-Ray Bursts with Extended Emission Observed with Swift/BAT and Fermi/GBM

    CERN Document Server

    Kaneko, Y; Gogus, E; Lin, L

    2015-01-01

    Some short GRBs are followed by longer extended emission, lasting anywhere from ~10 to ~100 s. These short GRBs with extended emission (EE) can possess observational characteristics of both short and long GRBs (as represented by GRB 060614), and the traditional classification based on the observed duration places some of them in the long GRB class. While GRBs with EE pose a challenge to the compact binary merger scenario, they may therefore provide an important link between short and long duration events. To identify the population of GRBs with EE regardless of their initial classifications, we performed a systematic search of short GRBs with EE using all available data (up to February 2013) of both Swift/BAT and Fermi/GBM. The search identified 16 BAT and 14 GBM detected GRBs with EE, several of which are common events observed with both detectors. We investigated their spectral and temporal properties for both the spikes and the EE, and examined correlations among these parameters. Here we present the resul...

  7. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    CERN Document Server

    Hynes, R I; Baum, Z A; Hsu, C -C; Cherry, M L; Scaringi, S

    2016-01-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal ...

  8. Short gamma-ray bursts with extended emission observed with Swift/BAT and Fermi/GBM

    Science.gov (United States)

    Kaneko, Y.; Bostancı, Z. F.; Göğüş, E.; Lin, L.

    2015-09-01

    Some short gamma-ray bursts (GRBs) are followed by longer extended emission (EE), lasting anywhere from ˜10 to ˜100 s. These short GRBs with EE can possess observational characteristics of both short and long GRBs (as represented by GRB 060614), and the traditional classification based on the observed duration places some of them in the long GRB class. While GRBs with EE pose a challenge to the compact-binary merger scenario, they may therefore provide an important link between short- and long-duration events. To identify the population of GRBs with EE regardless of their initial classifications, we performed a systematic search of short GRBs with EE using all available data (up to 2013 February) of both Swift/BAT and Fermi/GBM. The search identified 16 BAT and 14 GBM detected GRBs with EE, several of which are common events observed with both detectors. We investigated their spectral and temporal properties for both the spikes and the EE, and examined correlations among these parameters. Here we present the results of the systematic search as well as the properties of the identified events. Finally, their properties are also compared with short GRBs with EE observed with BATSE, identified through our previous search effort. We found several strong correlations among parameters, especially when all of the samples were combined. Based on our results, a possible progenitor scenario of two-component jet is discussed.

  9. The Fermi GBM gamma-ray burst time-resolved spectral catalog: brightest bursts in the first four years

    CERN Document Server

    Yu, Hoi-Fung; Greiner, Jochen; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Cleveland, William H; Connaughton, Valerie; Goldstein, Adam; von Kienlin, Andreas; Kouveliotou, Chryssa; Mailyan, Bagrat; Meegan, Charles A; Paciesas, William S; Rau, Arne; Roberts, Oliver J; Veres, Péter; Wilson-Hodge, Colleen; Zhang, Bin-Bin; van Eerten, Hendrik J

    2016-01-01

    We aim to obtain high-quality time-resolved spectral fits of gamma-ray bursts (GRBs) observed by the Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-ray Space Telescope. We perform time-resolved spectral analysis with high temporal and spectral resolution of the brightest bursts observed by Fermi GBM in its first 4 years of mission. We present the complete catalog containing 1,491 spectra from 81 bursts with high spectral and temporal resolution. Distributions of parameters, statistics of the parameter populations, parameter-parameter and parameter-uncertainty correlations, and their exact values are obtained and presented as main results in this catalog. We report a criterion that is robust enough to automatically distinguish between different spectral evolutionary trends between bursts. We also search for plausible blackbody emission components and find that only 3 bursts (36 spectra in total) show evidence of a pure Planck function. It is observed that the averaged time-resolved low-energy power-law...

  10. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Jenke, P; Case, Gary L; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Chaplin, Vandiver; Beklen, Elif; Finger, Mark H; Bhat, Narayana; Briggs, Michael S; Connaughto, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2013-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi Gamma-ray Space Telescope has been providing continuous data to the astronomical community since 2008 August 12. We will present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. Although the occultation technique is in principle quite simple, in practice there are many complications including the dynamic instrument response, source confusion, and scattering in the Earth's atmosphere, which will be described. We detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to ot...

  11. First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

    CERN Document Server

    Case, Gary L; Rodi, James C; Jenke, Peter; Wilson-Hodge, Colleen A; Finger, Mark H; Meegan, Charles A; Camero-Arranz, Ascencion; Beklen, Elif; Bhat, P Narayan; Briggs, Michael S; Chaplin, Vandiver; Connaughton, Valerie; Paciesas, William S; Preece, Robert; Kippen, R Marc; von Kienlin, Andreas; Griener, Jochen

    2010-01-01

    The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transien...

  12. THREE YEARS OF FERMI GBM EARTH OCCULTATION MONITORING: OBSERVATIONS OF HARD X-RAY/SOFT GAMMA-RAY SOURCES

    Energy Technology Data Exchange (ETDEWEB)

    Wilson-Hodge, Colleen A.; Jenke, Peter [ZP 12 Astrophysics Office, NASA Marshall Space Flight Center, Huntsville, AL 35812 (United States); Case, Gary L.; Cherry, Michael L.; Rodi, James [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803 (United States); Camero-Arranz, Ascension [Instituto de Ciencias del Espacio (IEEC-CSIC), Campus UAB, Torre C5, 2a planta, 08193 Barcelona (Spain); Chaplin, Vandiver; Bhat, Narayan; Briggs, Michael S.; Connaughton, Valerie; Preece, Robert [Physics Department, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Beklen, Elif [Physics Department, Suleyman Demirel University, 32260 Isparta (Turkey); Finger, Mark; Paciesas, William S. [Universities Space Research Association, Huntsville, AL 35805 (United States); Greiner, Jochen; Meegan, Charles A.; Von Kienlin, Andreas [Max-Planck Institut fuer Extraterrestische Physik, D-85748 Garching (Germany); Kippen, R. Marc [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2012-08-01

    The Gamma-ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper, we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, and 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found online.

  13. The Fermi GBM gamma-ray burst time-resolved spectral catalog: brightest bursts in the first four years

    Science.gov (United States)

    Yu, Hoi-Fung; Preece, Robert D.; Greiner, Jochen; Narayana Bhat, P.; Bissaldi, Elisabetta; Briggs, Michael S.; Cleveland, William H.; Connaughton, Valerie; Goldstein, Adam; von Kienlin, Andreas; Kouveliotou, Chryssa; Mailyan, Bagrat; Meegan, Charles A.; Paciesas, William S.; Rau, Arne; Roberts, Oliver J.; Veres, Péter; Wilson-Hodge, Colleen; Zhang, Bin-Bin; van Eerten, Hendrik J.

    2016-04-01

    Aims: We aim to obtain high-quality time-resolved spectral fits of gamma-ray bursts observed by the Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-ray Space Telescope. Methods: We performed time-resolved spectral analysis with high temporal and spectral resolution of the brightest bursts observed by Fermi GBM in its first four years of mission. Results: We present the complete catalog containing 1491 spectra from 81 bursts with high spectral and temporal resolution. Distributions of parameters, statistics of the parameter populations, parameter-parameter and parameter-uncertainty correlations, and their exact values are obtained and presented as main results in this catalog. We report a criterion that is robust enough to automatically distinguish between different spectral evolutionary trends between bursts. We also search for plausible blackbody emission components and find that only three bursts (36 spectra in total) show evidence of a pure Planck function. It is observed that peak energy and the averaged, time-resolved power-law index at low energy are slightly harder than the time-integrated values. Time-resolved spectroscopic results should be used instead of time-integrated results when interpreting physics from the observed spectra. Tables A.1 and B.1 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/588/A135

  14. Recent developments: Industry briefs

    International Nuclear Information System (INIS)

    This article is the 'Industry Briefs' portion of Nuexco's March 1991 'Recent Developments' section. Specific items discussed include: (1) a joint fuels venture between Nuexco and Energy Fuels, (2) bids for two nuclear units in Czechoslovakia, (3) plans for nuclear power in China, (4) uranium mining in Queensland, (5) marketing of nuclear power technology by India, and (6) uranium production in Australia

  15. Research in Brief.

    Science.gov (United States)

    Mulder, Ronald; And Others

    1980-01-01

    Presents brief reports of research conducted in the following areas: media credibility, network television news audiences, influences of television newscasters' on-camera image, Blacks in introductory advertisements, children's television preferences, messages in Depression-era photographs, and journalism education issues covered in two…

  16. 2011 SREB Legislative Briefing

    Science.gov (United States)

    Gaines, Gale F., Comp.

    2011-01-01

    The "2011 Legislative Briefing" is a topical summary of state budget and legislative actions that affect elementary, secondary and higher education across the Southern Regional Education Board (SREB) region. It outlines actions in areas such as tax and spending legislation, assistance to local districts, tuition and fees, student financial…

  17. Superintendent's Briefing Book, 2010

    Science.gov (United States)

    Educational Research Service, 2009

    2009-01-01

    The "2010 Superintendent's Briefing Book" provides comprehensive yet concise overviews of the best thinking available on a wide range of top-priority PreK-12 education concerns. This resource will prove invaluable in making research-based decisions with confidence, and in identifying programs and practices that will improve student achievement.…

  18. DCC Briefing Paper: Annotation

    OpenAIRE

    Abbott, Daisy

    2008-01-01

    The DCC has assembled a group of briefing papers that together form an introduction to curation. These concise overviews are designed to help grow your basic understanding of key curation issues by providing a high-level introduction to a given topic.

  19. Superintendent's Briefing Book, 2011

    Science.gov (United States)

    Educational Research Service, 2010

    2010-01-01

    The "2011 Superintendent's Briefing Book" provides comprehensive yet concise overviews of the best thinking available on a wide range of top-priority PreK-12 education concerns. This resource will prove invaluable in making research-based decisions with confidence, and in identifying programs and practices that will improve student achievement.…

  20. Informatics: A Brief Survey.

    Science.gov (United States)

    He, Shaoyi

    2003-01-01

    Provides a brief survey of informatics, defined as the application of information technology to various fields, with respect to its historical background, disciplinary identity, fundamental aspects, applications, and challenges. Highlights include biological, clinical, dental, environmental, geomatics, health, legal, management, medical, museum,…

  1. Research in Brief.

    Science.gov (United States)

    Journalism Quarterly, 1984

    1984-01-01

    Brief research reports discuss Latin America as seen on United States network television; television news coverage of federal regulatory agencies; community perceptions of media impressions; active television viewing and cultivation hypothesis; the impact of cable on traditional television news viewing; George Kibbe Turner; advertising; and…

  2. A Brief Demographic Portrait

    Science.gov (United States)

    Nieto, Sonia

    2012-01-01

    This article presents a brief demographic portrait, with particular emphasis on school-related issues, that points to the dire situation of Latino/a education. According to the 2010 Census, the number of Hispanics (the term used in government data) currently was 50,477,594 million, an increase of 43 percent since 2000, making this group the…

  3. Research in Brief.

    Science.gov (United States)

    Journalism Quarterly, 1982

    1982-01-01

    Offers brief descriptions of research concerning (1) media bias toward business, (2) foreign affairs coverage in elite and mass periodicals, (3) how emphasis on people affects coverage of crime, (4) antisocial and prosocial behavior on prime-time television, (5) network news coverage of Iran, and (6) magazines' reporting on insects. (FL)

  4. Issue Brief on Diversity

    Science.gov (United States)

    Division on Developmental Disabilities, Council for Exceptional Children (NJ1), 2013

    2013-01-01

    During the past year, the Diversity Committee of the Division of Developmental Disabilities (DDD) Board worked with the Board and the Issues Committee Chair to develop an issue brief addressing diversity, its impact on the membership and the wider community that is served by the work of DDD, resulting in recommendations that will influence policy…

  5. Academic Bankruptcy. Policy Brief.

    Science.gov (United States)

    Anderson, Amy Berk; Lewis, Anne C.

    In an effort to improve student achievement in low-performing districts, 22 states have developed academic bankruptcy laws, allowing them to intervene in districts that consistently fail to satisfy state education performance standards. This policy brief presents an overview of these statutes. The text offers a comparative summary of state…

  6. Cybernetics of Brief Family Therapy.

    Science.gov (United States)

    Keeney, Bradford P.; Ross, Jeffrey M.

    1983-01-01

    Presents a cybernetic view of brief family therapy. Includes a historical discussion of the key ideas underlying brief family therapy, a cybernetic model of therapeutic change, and a clinical case for exemplification. (Author/JAC)

  7. My brief history

    CERN Document Server

    Hawking, Stephen

    2013-01-01

    My Brief History recounts Stephen Hawking’s improbable journey, from his postwar London boyhood to his years of international acclaim and celebrity. Lavishly illustrated with rarely seen photographs, this concise, witty, and candid account introduces readers to a Hawking rarely glimpsed in previous books: the inquisitive schoolboy whose classmates nicknamed him Einstein; the jokester who once placed a bet with a colleague over the existence of a particular black hole; and the young husband and father struggling to gain a foothold in the world of physics and cosmology. Writing with characteristic humility and humor, Hawking opens up about the challenges that confronted him following his diagnosis of ALS at age twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time—one of the iconic books of the twentieth century.

  8. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Directory of Open Access Journals (Sweden)

    Nicolas M Bertagnolli

    Full Text Available To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  9. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    Science.gov (United States)

    Hynes, Robert I.; Schaefer, Bradley E.; Baum, Zachary A.; Hsu, Ching-Cheng; Cherry, Michael L.; Scaringi, Simone

    2016-04-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal reprocessing of X-ray flares. The low state anti-correlation is broader, consistent with optical lags of between zero and 30 min, and strongest with respect to high energy X-rays. We suggest that the decreases in optical flux in the low state may reflect decreasing efficiency of disc irradiation, caused by changes in the illumination geometry. These changes could reflect the vertical extent or covering factor of obscuration or the optical depth of scattering material.

  10. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.

    Science.gov (United States)

    Crawford, Forrest W; Khayal, Inas S; McGue, Colleen; Saraswathy, Suja; Pirzkall, Andrea; Cha, Soonmee; Lamborn, Kathleen R; Chang, Susan M; Berger, Mitchel S; Nelson, Sarah J

    2009-02-01

    Glioblastoma Multiforme (GBM) are heterogeneous lesions, both in terms of their appearance on anatomic images and their response to therapy. The goal of this study was to evaluate the prognostic value of parameters derived from physiological and metabolic images of these lesions. Fifty-six patients with GBM were scanned immediately before surgical resection using conventional anatomical MR imaging and, where possible, perfusion-weighted imaging, diffusion-weighted imaging, and proton MR spectroscopic imaging. The median survival time was 517 days, with 15 patients censored. Absolute anatomic lesion volumes were not associated with survival but patients for whom the combined volume of contrast enhancement and necrosis was a large percentage of the T2 hyperintense lesion had relatively poor survival. Other volumetric parameters linked with less favorable survival were the volume of the region with elevated choline to N-acetylaspartate index (CNI) and the volume within the T2 lesion that had apparent diffusion coefficient (ADC) less than 1.5 times that in white matter. Intensity parameters associated with survival were the maximum and the sum of levels of lactate and of lipid within the CNI lesion, as well as the magnitude of the 10th percentile of the normalized ADC within the contrast-enhancing lesion. Patients whose imaging parameters indicating that lesions with a relatively large percentage with breakdown of the blood brain barrier or necrosis, large regions with abnormal metabolism or areas with restricted diffusion have relatively poor survival. These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials. PMID:19009235

  11. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy.

    Science.gov (United States)

    Saraswathy, Suja; Crawford, Forrest W; Lamborn, Kathleen R; Pirzkall, Andrea; Chang, Susan; Cha, Soonmee; Nelson, Sarah J

    2009-01-01

    Purpose Glioblastoma Multiforme (GBM) is the most common and lethal primary brain tumor in adults. The goal of this study was to test the predictive value of MR parameters in relation to the survival of patients with newly diagnosed GBM who were scanned prior to receiving adjuvant radiation and chemotherapy. Methods The study population comprised 68 patients who had surgical resection and were to be treated with fractionated external beam radiation therapy and chemotherapy. Imaging scans included anatomical MRI, diffusion and perfusion weighted imaging and (1)H MRSI. The MR data were acquired 3-5 weeks after surgery and approximately 1 week before treatment with radiation therapy. The diffusion, perfusion and spectroscopic parameter values were quantified and subjected to proportional hazards analysis that was adjusted for age and scanner field strength. Results The patients with larger lesion burden based upon volumes of anatomic lesions, volume of CNI2 (number of voxels within the T2 lesion having choline to NAA index >2), volume of CBV3 (number of pixels within the T2 lesion having relative cerebral blood volume >3), and volume of nADC1.5 (number of pixels within the T2 lesion having normalized apparent diffusion coefficient <1.5) had a higher risk for poor outcome. High intensities of combined measures of lactate and lipid in the T2 and CNI2 regions were also associated with poor survival. Conclusions Our study indicated that several pre-treatment anatomic, physiological and metabolic MR parameters are predictive of survival. This information may be important for stratifying patients to specific treatment protocols and for planning focal therapy. PMID:18810326

  12. Strategic forces briefing

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  13. Recent developments: Industry briefs

    International Nuclear Information System (INIS)

    This article is the 'Industry Briefs' portion of Nuexco's July 1992 'Recent Developments' section. Specific items mentioned include: (1) the merger of Entergy and Gulf States Utilities, (2) restart of the Sequoyah Fuels facility in Oklahoma, (3) development of the 7th and 8th nuclear units in Taiwan, (4) purchase of interest in Rio Algom, Ltd, and (5) acquisition of the Italian firm AGIP by a Canadian company

  14. Brief review: delirium

    OpenAIRE

    Schmitz ED; Vu JB

    2014-01-01

    No abstract available. Article truncated after 150 words. A significant number of patients develop a decline in cognitive function while hospitalized. Delirium in the intensive care increases mortality and healthcare costs and should be recognized and treated promptly (1,2). This is a brief review of delirium and important treatment options such as early percutaneous tracheostomy, neuroleptics, propofol, daily awakenings and reorientation by all team members. We recommend neither neuroimaging...

  15. Brief introduction to relativity

    International Nuclear Information System (INIS)

    A brief, but rigorous and uncondensed, introduction to special relativity is given. The reader is assumed to be familiar with coordinate transformations in general and to have a reasonable grasp of advanced calculus and vector analysis. The subject is presented under the following topics: hypotheses underlying the Lorentz transformation, kinematics and algebraic properties of the Lorentz transformation, vectors and tensors in relativity, the electromagnetic field and Maxwell's equations, the dynamics of a particle and the Lorentz force equation, photons and relativistic optics, and applications of relativistic optics. 3 figures

  16. Intravitreal bevacizumab (avastin for circumscribed choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Subrata Mandal

    2011-01-01

    Full Text Available Circumscribed choroidal hemangiomas are rare ophthalmic entities that cause diminution in vision due to accumulation of subretinal and/or intraretinal fluid in the macular area. Various treatment options ranging from conventional laser to photodynamic therapy have been employed to destroy the tumor and reduce the exudation; however, either the inability to penetrate through the exudative fluid or the collateral retinal damage induced by these treatment modalities make them unsuitable for lesions within the macula. We evaluated the role of intravitreal bevacizumab, a pan-vascular endothelial growth factor (VEGF inhibitor, in reducing the sub- and intraretinal fluid in three patients with circumscribed choroidal hemangiomas. All the patients had complete resolution of the serous retinal detachment that was maintained till at least 12 months after the first injection. Intravitreal bevacizumab may be used in combination with thermal laser or photodynamic therapy in treating circumscribed choroidal hemangiomas with subretinal fluid.

  17. Sustainable Markets Investment Briefings: Overview

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the first of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 1 provides a general overview of key issues.

  18. Brief encounter networks

    CERN Document Server

    Kostakos, Vassilis; Penn, Alan

    2007-01-01

    Many complex human and natural phenomena can usefully be represented as networks describing the relationships between individuals. While these relationships are typically intermittent, previous research has used network representations that aggregate the relationships at discrete intervals. However, such an aggregation discards important temporal information, thus inhibiting our understanding of the networks dynamic behaviour and evolution. We have recorded patterns of human urban encounter using Bluetooth technology thus retaining the temporal properties of this network. Here we show how this temporal information influences the structural properties of the network. We show that the temporal properties of human urban encounter are scale-free, leading to an overwhelming proportion of brief encounters between individuals. While previous research has shown preferential attachment to result in scale-free connectivity in aggregated network data, we found that scale-free connectivity results from the temporal prope...

  19. Duration distributions for gamma-ray bursts registered in various experiments since VENERA11/KONUS up to Fermi/GBM.

    Science.gov (United States)

    Arkhangelskaja, I. V.

    2016-02-01

    Gamma-ray bursts duration distributions properties for events registered by experiments CGRO/BATSE, VENERA11/KONUS, VENERA12/KONUS, Swift/BAT, GRANAT/PHEBUS, Suzaku/WAM, RHESSI and Fermi/GBM are considered. GRBs observed since 1967 and now several thousands of events were listed in more than 30 catalogues. Gamma-ray bursts duration distribution was the first analysed using data of BATSE instrument onboard the CGRO. The GRBs duration distribution analysis had shown the existence of two bursts classes: long and short separated by t90 = 2 s. But results of similar distributions for bursts observed by other detectors have shown shifting of boundary between short and long events from value of 2 s. For example, Swift/BAT GRBs subset analysis gives the value of ∼1 s for this separator point. Moreover, t90 has dependence from instrument registered this burst - it is function of detector sensitivity threshold and operation energy band. For instance, the duration of GRB060418 burst t90 is ∼52 s according to Swift/BAT data and only 36 s according to RHESSI data. Therefore, the type of GGB (whether it short or long) should be defined only taking into account distinctive features of instrument detected this event. Also attributes of third intermediate GRBs subgroup appearance in events subsets for various detectors are discussed. Firstly this subgroup was found some years ago in BATSE GRB duration and duration-hardness distributions.

  20. The Fermi-GBM X-ray burst monitor: thermonuclear bursts from 4U 0614+09

    CERN Document Server

    Linares, M; Jenke, P; van der Horst, A J; Camero-Arranz, A; Kouveliotou, C; Chakrabarty, D; Beklen, E; Bhat, P N; Briggs, M S; Finger, M; Paciesas, W; Preece, R; von Kienlin, A; Wilson-Hodge, C A

    2012-01-01

    Thermonuclear bursts from slowly accreting neutron stars (NSs) have proven difficult to detect, yet they are potential probes of the thermal properties of the neutron star interior. During the first year of a systematic all-sky search for X-ray bursts using the Gamma-ray Burst Monitor (GBM) aboard the Fermi Gamma-ray Space Telescope we have detected 15 thermonuclear bursts from the NS low-mass X-ray binary 4U 0614+09, when it was accreting at nearly 1% of the Eddington limit. We measured an average burst recurrence time of 12+/-3 d (68% confidence interval) between March 2010 and March 2011, classified all bursts as normal duration bursts and placed a lower limit on the recurrence time of long/intermediate bursts of 62 d (95% confidence level). We discuss how observations of thermonuclear bursts in the hard X-ray band compare to pointed soft X-ray observations, and quantify such bandpass effects on measurements of burst radiated energy and duration. We put our results for 4U 0614+09 in the context of other bu...

  1. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

    Directory of Open Access Journals (Sweden)

    Yajuan Li

    Full Text Available Previously we have shown that kallikreins (klks play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1 gene was transduced into murine MSCs using a retroviral vector to generate a stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected to anti-GBM induced nephritis were transplanted with 10(6 hKLK1-MSCs and hKLK1 expression was confirmed in the kidneys. Compared with vector-MSCs injected mice, the hKLK1-MSCs treated mice showed significantly reduced proteinuria, blood urea nitrogen (BUN and ameliorated renal pathology. Using the same strategy, we treated lupus-prone B6.Sle1.Sle3 bicongenic mice with hKLK1-MSCs and demonstrated that hKLK1-MSCs delivery also attenuated lupus nephritis. Mechanistically, hKLK1-MSCs reduced macrophage and T-lymphocyte infiltration into the kidney by suppressing the expression of inflammation cytokines. Moreover, hKLK1 transduced MSCs were more resistant to oxidative stress-induced apoptosis. These findings advance genetically modified MSCs as potential gene delivery tools for targeting therapeutic agents to the kidneys in order to modulate inflammation and oxidative stress in lupus nephritis.

  2. Earth Occultation Imaging Applied to BATSE -- Application to a Combined BATSE-GBM Survey of the Hard X-Ray Sky

    CERN Document Server

    Zhang, Yuan; Case, Gary; Ling, James; Wheaton, William

    2013-01-01

    A combined BATSE-GBM hard X-ray catalog is presented based on Earth Occultation Imaging applied to a reanalysis of BATSE data. An imaging approach has been developed for the reanalysis of Earth Occultation analysis of BATSE data. The standard occultation analysis depends on a predetermined catalog of potential sources, so that a real source not present in the catalog may induce systematic errors when source counts associated with an uncatalogued source are incorrectly attributed to catalog sources. The goal of the imaging analysis is to find a complete set of hard X-ray sources, including sources not in the original BATSE occultation catalog. Using the imaging technique, we have identified 15 known sources and 17 unidentified sources and added them to the BATSE occultation catalog. The resulting expanded BATSE catalog of sources observed during 1991-2000 is compared to the ongoing GBM survey.

  3. Fermi Guest Investigator Program Cycle 2 Project Final Report Albedo Polarimetry of Gamma-Ray Bursts and Solar Flares with GBM

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Richard Marc [Los Alamos National Laboratory

    2012-08-27

    Several key properties of GRBs remain poorly understood and are difficult or even impossible to infer with the information currently being collected. Polarization measurements will probe the precise nature of the central engine. For solar flares, high-energy polarization measurements are expected to be useful in determining the beaming (or directivity) of solar flare electrons - a quantity that may provide important clues about electron acceleration and transport. We propose to investigate the viability of using the Fermi Gamma-ray Burst Monitor (GBM) to measure the polarization of GRBs and solar flares using the albedo photon flux. This approach was previously developed for use with BATSE data. We will conduct a careful study of this technique using a modified version of the GRESS simulation tools developed by the GBM team.

  4. Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: A multi-center study

    OpenAIRE

    Pope, WB; Qiao, XJ; Kim, HJ; Lai, A.; Nghiemphu, P; Xue, X.; Ellingson, BM; Schiff, D.; Aregawi, D; Cha, S; Puduvalli, VK; Wu, J.; Yung, WKA; Young, GS; Vredenburgh, J

    2012-01-01

    We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patients with recurrent glioblastoma multiforme (GBM) from the multi-center BRAIN study. Available MRI's from patients enrolled in the BRAIN study (n = 97) were examined by generating ADC histograms from areas of enhancing tumor on T1 weighted post-contrast images fitted to a two normal distribution mixtu...

  5. Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase

    OpenAIRE

    Paixão-Cavalcante, Danielle; Hanson, Steven; Botto, Marina; Cook, H. Terence; Pickering, Matthew C.

    2009-01-01

    Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh −/−) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a lesion dependent on C3 activation. In order to understand the role of CFH in preventing renal damage associated with the dysregulation of the alternative pathway we administered p...

  6. Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

    Directory of Open Access Journals (Sweden)

    Ravi D. Rao

    2005-10-01

    Full Text Available Elevated epidermal growth factor receptor (EGFR and mammalian target of rapamycin (mTOR signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM, which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target these protein kinases have been evaluated in multiple clinical trials for cancer patients, including those with GBM. Here we have examined the cellular and molecular effects of a combined kinase inhibition of mTOR (rapamycin and EGFR (EKI-785 in U87 and U251 GBM cells. Simultaneous treatment with rapamycin and EKI-785 results in synergistic antiproliferative as well as proapoptotic effects. At a molecular level, rapamycin alone significantly decreases S6 phosphorylation, whereas EKI-785 alone promotes substantially reduced signal transducer and activator of transcription (STAT3 phosphorylation. Treatment with rapamycin alone also increases Akt phosphorylation on Ser-473, but this effect is blocked by a simultaneous administration of EKI-785. Individually, EKI-785 diminishes while rapamycin promotes the binding of the translation inhibitor eukaryotic initiation factor 4E binding protein (4EBP1 to the eukaryotic translation initiation factor 4E (eIF4E. In spite of these opposing effects, the highest level of 4EBP1-eIF4E binding occurs with the combination of the two inhibitors. These results indicate that the inhibition of EGFR and mTOR has distinct as well as common signaling consequences and provides a molecular rationale forthe synergistic antitumor effects of EKI-785 and rapamycin administration.

  7. Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome

    Directory of Open Access Journals (Sweden)

    Kistler Thomas

    2011-06-01

    Full Text Available Abstract Background Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients presenting as anti-GBM antibody positive pulmonary-renal syndrome or rapidly progressive glomerulonephritis are also tested positive for anti-neutrophil cytoplasmic antibodies (ANCA. Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable. Case Presentation We report a patient with such dual positivity, who presented with pulmonary hemorrhage, crescentic glomerulonephritis and membranous nephropathy. Plasmapheresis in combination with immunosuppresive therapy led to a rapid remission but the disease relapsed after two years. The serum of the patient was tested positive for antibodies to human lysosomal membrane protein 2 (hLAMP2, a novel autoantigen in patients with active small-vessel vasculitis (SVV. The anti-hLAMP2 antibody levels correlated positively with clinical disease activity in this patient. Conclusion We hypothesize that this antibody may indicate a clinical course similar to ANCA-associated vasculitis in double-positive patients. However, this needs to be confirmed on comprehensive patient cohorts.

  8. Epidermal growth factor receptor (EGFR mutation status and Rad51 determine the response of glioblastoma (GBM to multimodality therapy with cetuximab, temozolomide and radiation

    Directory of Open Access Journals (Sweden)

    PhyllisRachelleWachsberger

    2013-02-01

    Full Text Available Purpose: EGFR amplification and mutation (i.e., EGFRvIII are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulates response to multimodality treatment with cetuximab, an anti-EGFR inhibitor, the chemotherapeutic agent, temozolamide (TMZ and radiation therapy (RT Methods and Materials: In vitro and in vivo experiments were performed on two isogenic U87 GBM cell lines: one overexpressing wildtype EGFR (U87wtEGFR and the other overexpressing EGFRvIII (U87EGFRvIII. Results: Xenografts harboring EGFRvIII were more sensitive to TMZ alone and TMZ in combination with RT and/or cetuximab than xenografts expressing wtEGFR. In vitro experiments demonstrated that U87EGFRvIII-expressing tumors appear to harbor defective DNA homologous recombination repair in the form of Rad51 processing, Conclusions: The difference in sensitivity between EGFR-expressing and EGFRvIII-expressing tumors to combined modality treatment may help in the future tailoring of GBM therapy to subsets of patients expressing more or less of the EGFR mutant.

  9. Integrative Analysis of mRNA, microRNA, and Protein Correlates of Relative Cerebral Blood Volume Values in GBM Reveals the Role for Modulators of Angiogenesis and Tumor Proliferation

    Science.gov (United States)

    Rao, Arvind; Manyam, Ganiraju; Rao, Ganesh; Jain, Rajan

    2016-01-01

    Dynamic susceptibility contrast-enhanced magnetic resonance imaging is routinely used to provide hemodynamic assessment of brain tumors as a diagnostic as well as a prognostic tool. Recently, it was shown that the relative cerebral blood volume (rCBV), obtained from the contrast-enhancing as well as -nonenhancing portion of glioblastoma (GBM), is strongly associated with overall survival. In this study, we aim to characterize the genomic correlates (microRNA, messenger RNA, and protein) of this vascular parameter. This study aims to provide a comprehensive radiogenomic and radioproteomic characterization of the hemodynamic phenotype of GBM using publicly available imaging and genomic data from the Cancer Genome Atlas GBM cohort. Based on this analysis, we identified pathways associated with angiogenesis and tumor proliferation underlying this hemodynamic parameter in GBM. PMID:27053917

  10. Brief review: delirium

    Directory of Open Access Journals (Sweden)

    Schmitz ED

    2014-12-01

    Full Text Available No abstract available. Article truncated after 150 words. A significant number of patients develop a decline in cognitive function while hospitalized. Delirium in the intensive care increases mortality and healthcare costs and should be recognized and treated promptly (1,2. This is a brief review of delirium and important treatment options such as early percutaneous tracheostomy, neuroleptics, propofol, daily awakenings and reorientation by all team members. We recommend neither neuroimaging nor neurology consultation unless physical exam suggests an acute cerebral vascular accident or status epilepticus as the majority of these patients require no neurologic intervention and may be harmed by transportation to obtain additional testing. The DSM-5 defines delirium as a disturbance in attention (reduced ability to direct, focus, sustain, and shift attention and awareness (reduced orientation to the environment. The disturbance develops over a short period of time (usually hours to a few days, represents a change from baseline attention and awareness, and tends to fluctuate in severity ...

  11. Analytical modeling of pulse-pileup distortion using the true pulse shape; applications to Fermi-GBM

    Energy Technology Data Exchange (ETDEWEB)

    Chaplin, Vandiver, E-mail: chapliv@uah.edu [CSPAR, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899 (United States); Bhat, Narayana [CSPAR, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899 (United States); Briggs, Michael S.; Connaughton, Valerie [CSPAR, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899 (United States); Department of Physics, University of Alabama in Huntsville, 301 Sparkman Drive, Huntsville, AL 35899 (United States)

    2013-07-21

    Pulse-pileup affects most photon counting systems and occurs when photon detections occur faster than the detector's shaping and recovery time. At high input rates, shaped pulses interfere and the source spectrum, as well as intensity information, get distorted. For instruments using bipolar pulse shaping there are two aspects to consider: ‘peak’ and ‘tail’ pileup effects, which raise and lower the measured energy, respectively. Peak effects have been extensively modeled in the past. Tail effects have garnered less attention due to increased complexity. We leverage previous work to derive an accurate, semi-analytical prediction for peak and tail pileup including high order effects. We use the pulse shape of the detectors of the Fermi Gamma-ray Burst Monitor. The measured spectrum is calculated by expressing exposure time with a state-space expansion of overlapping pileup states and is valid up to very high rates. The model correctly predicts deadtime and pileup losses, and energy-dependent losses due to tail subtraction (sub-threshold) effects. We discuss total losses in terms of the true rate of photon detections versus the recorded count rate. -- Highlights: • A derivation of pulse-pileup spectral and intensity distortion is presented. • Applies to bipolar shaping instruments in general, but is calculated for Fermi-GBM. • Exposure time is partitioned with pulse widths as states of a Poisson process. • Each state has an associated energy distribution function for peak and tail pileup. • The total spectrum is the union of pulse states and their associated spectra.

  12. Boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM), using the epithermal neutron beam at the Brookhaven National Laboratory

    International Nuclear Information System (INIS)

    Objective: BNCT is a binary treatment modality based on the nuclear reactions that occur when boron (10B) is exposed to thermal neutrons. Preclinical studies have demonstrated the therapeutic efficacy of p-boronophenylalanine (BPA)-based BNCT. The objective of the Phase I/II trial was to evaluate BPA-fructose (BPA-F) as a boron delivery agent for GBM and to study the feasibility and safety of a single-fraction of BNCT. Materials and Methods: The trial design required i) a BPA-F biodistribution study performed at the time of craniotomy; and ii) BNCT within 4 weeks of the craniotomy. From September 94 to July 95, 10 patients with biopsy proven GBM were treated. All but 1 patient underwent a biodistribution study receiving IV BPA-F at the time of craniotomy. Multiple tissue samples and concurrent blood and urine samples were collected for evaluation of the boron concentration and clearance kinetics. For BNCT all patients received 250 mg/kgm of BPA-F (IV infusion over 2 hrs) followed by neutron irradiation. The blood 10B concentration during irradiation was used to calculate the time of neutron exposure. The 3D treatment planning was done using the BNCT treatment planning software developed at the Idaho National Engineering Laboratory. The BNCT dose is expressed as the sum of the physical dose components corrected for both the RBE and the 10B localization factor with the unit Gy-Eq. The photon-equivalent dose, where the thermal neutron fluence reaches a maximum, is the peak-dose equivalent. A single-fraction of BNCT was delivered prescribing 10.5 Gy-Eq (9 patients) and 13.8 Gy-Eq (1 patient) as the peak dose-equivalent to the normal brain. The peak dose rate was kept below 27 cGy-Eq/min. Results: Biodistribution data: The maximum blood 10B concentration was observed at the end of the infusion and scaled as a linear function of the administered dose. The 10B concentration in the scalp and in the GBM tissue was higher than in blood by 1.5 x and at least 3.5 x

  13. Neuroophthalmology A brief Vademecum

    International Nuclear Information System (INIS)

    The stunning, intricate interaction between the visual, vestibular and optomotor systems--each a miracle on its own--ensures maintenance of orientation in space as well as visual recognition and target selection despite a host of sensory conflicts and adversary disturbances. Their main goals are to keep a target of interest on the fovea by either maintaining or shifting the direction of gaze in order to produce an accurate internal representation of the visual surroundings, in particular the selected target, and to continuously mirror the spatial relationship between these various visual elements and the self. Not surprising, the implementation of this host of elaborate neural networks encompasses almost every part of the brain, including the brainstem, cerebellum, extrapyramidal system and many areas of the cerebral cortex. Thus far, these systems are among the best investigated in brain research; and enormous knowledge was amassed over the last century employing a variety of techniques, including single cell recordings, eye movement studies, functional imaging and neuropsychological observations. In addition, this prolific line of research has enlightened many fundamental principles of neural and neuronal processing, which have subsequently enriched other fields of brain research as well as computational neuroscience, e.g. the discovery of receptive fields, which have now become a ubiquitous concept in many other areas of neurophysiology. This (improperly) brief, fractional and undoubtedly biased Vademecum is meant to accompany the reader into this marvellous field of neurophysiology and neurology. In particular, it stresses the clinical application of its functional neuroanatomy at the bedside, which, in many respects, is superior to other means of investigating a patient

  14. ENDL transmittal format. Brief summary

    International Nuclear Information System (INIS)

    The LLNL Evaluated Neutron Data Library of 1982 (ENDL-82) and the LLNL Evaluated Charged Particle Library (ECPL-86) are available in the ENDL Transmittal Format, of which a brief user's guide is given in this document. (author)

  15. Spanish Language Briefs for Parents, 1995.

    Science.gov (United States)

    ERIC Clearinghouse on Rural Education and Small Schools, Charleston, WV.

    This packet contains six briefs developed specifically for Spanish-speaking parents of Mexican origin, and English translations of the briefs. In plain language, these briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. Titles of the briefs are (1) "Apoyando el…

  16. Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — Fermi is a powerful space observatory that will open a wide window on the universe. Gamma rays are the highest-energy form of light, and the gamma-ray sky is...

  17. Characterization of biological features of a rat F98 GBM model: A PET-MRI study with [18F]FAZA and [18F]FDG

    International Nuclear Information System (INIS)

    Introduction: The prognosis of malignant gliomas remains largely unsatisfactory for the intrinsic characteristics of the pathology and for the delayed diagnosis. Multimodal imaging based on PET and MRI may assess the dynamics of disease onset and progression allowing the validation of preclinical models of glioblastoma multiforme (GBM). The aim of this study was the characterization of a syngeneic rat model of GBM using combined in vivo imaging and immunohistochemistry. Methods: Four groups of Fischer rats were implanted in a subcortical region with increasing concentration of rat glioma F98 cells and weekly monitored with Gd-MR, [18F]FDG- and [18F]FAZA-PET starting one week after surgery. Different targets were evaluated on post mortem brain specimens using immunohistochemistry: VEGF, GFAP, HIF-1α, Ki-67 and nestin. Results: Imaging results indicated that tumor onset but not progression was related to the number of F98 cells. Hypoxic regions identified with [18F]FAZA and high-glucose metabolism regions recognized with [18F]FDG were located respectively in the core and in external areas of the tumor, with partial overlap and remodeling during disease progression. Histological and immunohistochemical analysis confirmed PET/MRI results and revealed that our model resumes biological characteristics of human GBM. IHC and PET studies showed that necrotic regions, defined on the basis of [18F]FDG uptake reduction, may include hypoxic clusters of vital tumor tissue identified with [18F]FAZA. This last information is particularly relevant for the identification of the target volume during image-guided radiotherapy. Conclusions: In conclusion, the combined use of PET and MRI allows in vivo monitoring of the biological modification of F98 lesions during tumor progression

  18. Electricity Storage. Technology Brief

    Energy Technology Data Exchange (ETDEWEB)

    Simbolotti, G. [Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Rome (Italy); Kempener, R. [International Renewable Energy Agency IRENA, Bonn (Germany)

    2012-04-15

    Electricity storage is a key technology for electricity systems with a high share of renewables as it allows electricity to be generated when renewable sources (i.e. wind, sunlight) are available and to be consumed on demand. It is expected that the increasing price of fossil fuels and peak-load electricity and the growing share of renewables will result in electricity storage to grow rapidly and become more cost effective. However, electricity storage is technically challenging because electricity can only be stored after conversion into other forms of energy, and this involves expensive equipment and energy losses. At present, the only commercial storage option is pumped hydro power where surplus electricity (e.g. electricity produced overnight by base-load coal or nuclear power) is used to pump water from a lower to an upper reservoir. The stored energy is then used to produce hydropower during daily high-demand periods. Pumped hydro plants are large-scale storage systems with a typical efficiency between 70% and 80%, which means that a quarter of the energy is lost in the process. Other storage technologies with different characteristics (i.e. storage process and capacity, conversion back to electricity and response to power demand, energy losses and costs) are currently in demonstration or pre-commercial stages and discussed in this brief report: Compressed air energy storage (CAES) systems, Flywheels; Electrical batteries; Supercapacitors; Superconducting magnetic storage; and Thermal energy storage. No single electricity storage technology scores high in all dimensions. The technology of choice often depends on the size of the system, the specific service, the electricity sources and the marginal cost of peak electricity. Pumped hydro currently accounts for 95% of the global storage capacity and still offers a considerable expansion potential but does not suit residential or small-size applications. CAES expansion is limited due to the lack of suitable

  19. Usability Briefing for hospital design

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    building project. In practice the process, led by experts, involves the users as data sources, and results in the program of requirements for the building.This PhD thesis synthesizes the research findings and proposes a Usability Briefing process model, where briefing is a dynamic and continuous process....../usability or form/beauty. Furthermore appropriate methods are selected specifically for hospital projects.The results are published in five scientific articles and are summarised in this PhD thesis. It provides tools that contribute to satisfying the needs of future building users and maximising the usability...

  20. Study of luminosity and spin-up relation in X-ray binary pulsars with long-term monitoring by MAXI/GSC and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Nakajima, Motoki; Yamaoka, Kazutaka

    2015-01-01

    We study the relation between luminosity and spin-period change in X-ray binary pulsars using long-term light curve obtained by the MAXI/GSC all-sky survey and pulse period data from the Fermi/GBM pulsar project. X-ray binaries, consisting of a highly magnetized neutron star and a stellar companion, originate X-ray emission according to the energy of the accretion matter onto the neutron star. The accretion matter also transfers the angular momentum at the Alfven radius, and then spin up the neutron star. Therefore, the X-ray luminosity and the spin-up rate are supposed to be well correlated. We analyzed the luminosity and period-change relation using the data taken by continuous monitoring of MAXI/GSC and Fermi/GBM for Be/X-ray binaries, GX 304$-$1, A 0535$+$26, GRO J1008$-$57, KS 1947$+$300, and 2S 1417$-$624, which occurred large outbursts in the last four years. We discuss the results comparing the obtained observed relation with that of the theoretical model by Ghosh \\& Lamb (1979).

  1. Public Health England Briefing Papers

    OpenAIRE

    Public Health England

    2013-01-01

    -Social and economic inequalities in diet and physical activity - Obesity and disability - adults - Obesity and alcohol - an overview - A simple guide to classifying body mass index in children - Knowledge and attitudes towards healthy eating and physical activity - Brief intervetions for weight management - Data sources:environmental influences on physical activity and diet - Measuring diet and physical activity in weight management interventions - Obesity and Mental ...

  2. Brief Psychotherapy: The Multimodal Model.

    Science.gov (United States)

    Lazarus, Arnold A.

    1989-01-01

    Outlines tenets of multimodal therapy (MMT) and argues for its cost-effective yet comprehensive value as a brief psychotherapy model. Describes MMT as an integrated, seven-modality model of personality and provides clinical examples of its use. Argues that MMT approach will be an important future alternative to more expensive, time-consuming, and…

  3. Inclusive Briefing and User Involvement

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2011-01-01

    number of different processes with varying purposes before and during the design and construction activities. Thus, briefing can be regarded as a continuous process but it should also be an inclusive and interactive process with the involvement of all stakeholders, including end users. This article...

  4. BRIEFING ABOUT SIMCORB BUSINESS PLAN

    Science.gov (United States)

    The SIMCorB Business Plan was discussed at the ORD Infrastructure Meeting held on July 17, 2000 in Washington, D.C.The briefing explained the purpose of the Plan as a vehicle to provide a road map to attain the ORD science IM vision. The road map includes defined milestones, bu...

  5. Brief Counseling with Hispanic American College Students.

    Science.gov (United States)

    Littrell, John M.; Cruz, Jeannette

    1998-01-01

    Hispanic-American college students (N=16) met with a Puerto-Rican counselor for two brief counseling sessions. Brief counseling was a viable and effective approach in helping the students reach their goals. Examined types of student concerns about, and student perceptions of, brief counseling. (Author)

  6. 50 CFR 37.33 - Environmental briefing.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Environmental briefing. 37.33 Section 37..., ARCTIC NATIONAL WILDLIFE REFUGE, ALASKA Environmental Protection § 37.33 Environmental briefing. The... briefings for all of its personnel involved in field operations prior to commencement of field work...

  7. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    Directory of Open Access Journals (Sweden)

    Garcia Juan L

    2010-08-01

    Full Text Available Abstract Background Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Methods Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Results Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders. Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups

  8. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    International Nuclear Information System (INIS)

    Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders). Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups of samples: those discriminated by tumour location

  9. A Brief History of Context

    CERN Document Server

    Wan, Kaiyu

    2009-01-01

    Context is a rich concept and is an elusive concept to define. The concept of context has been studied by philosophers, linguists, psychologists, and recently by computer scientists. Within each research community the term context was interpreted in a certain way that is well-suited for their goals, however no attempt was made to define context. In many areas of research in computer science, notably on web-based services, human-computer interaction (HCI), ubiquitous computing applications, and context-aware systems there is a need to provide a formal operational definition of context. In this brief survey an account of the early work on context, as well as the recent work on many working definitions of context, context modeling, and a formalization of context are given. An attempt is made to unify the different context models within the formalization. A brief commentary on the usefulness of the formalization in the development of context-aware and dependable systems is included.

  10. Brief Psychotherapy in Family Practice

    OpenAIRE

    MacDonald, Peter J.; Brown, Alan

    1986-01-01

    A large number of patients with psychosocial or psychiatric disorders present to family physicians, and the family physician needs a model of psychotherapy with which to cope with their problems. A model of brief psychotherapy is presented which is time limited, goal directed and easy to learn. It consists of four facets drawn from established areas of psychotherapy: characteristics of the therapist; characteristics of the patient; Eriksonian developmental stages; and the process of therapy a...

  11. A brief history of videogames

    OpenAIRE

    Simone Belli; Cristian López

    2008-01-01

    The following text contains a brief journey through a short and yet intense adventure, the history of videogames. Since its beginnings in the 1950's decade to the present time, videogames have progressively changed from a hobby for ingeneering studens to the most powerfull leisure industry. In order to gain a better understanding of this phenomenon it is necessary to look over the path of its transformation from a retrospecive point of view. Such a look has necessarily t...

  12. Geothermal reservoirs - A brief review

    OpenAIRE

    Ganguly, Sayantan; Kumar, Mohan MS

    2012-01-01

    A brief discussion and review of the geothermal reservoir systems, geothermal energy and modeling and simulation of the geothermal reservoirs has been presented here. Different types of geothermal reservoirs and their governing equations have been discussed first. The conceptual and numerical modeling along with the representation of flow though fractured media, some issues related to non isothermal flow through fractured media, the efficiency of the geothermal reservoir, structure of the num...

  13. P17.14A PROPOSAL OF A MODIFIED STUPP'S SCHEDULE WITH PROLONGED ADJUVANT TEMOZOLOMIDE: EXPERIENCE OF A SINGLE INSTITUTION IN A SERIES OF 100 CONSECUTIVE GBM PATIENTS

    Science.gov (United States)

    Caroli, M.; Minichiello, M.; Di Cristofori, A.; Lanfranchi, G.; Bertani, G.; Carrabba, G.; Rampini, P.

    2014-01-01

    BACKGROUND: Glioblastoma (GBM) is a primary malignant brain tumor and its evolution is generally rapidly fatal. The current standard of care for this disease is surgical resection followed by concomitant radiationtherapy plus chemiotherapy as described by Stupp and Colleagues. In this study we described our experience in a series of 100 consecutive patients affected by GBM treated with modified Stupp regimen at “Fondazione IRCCS Ca' Granda Ospedale Policlinico Maggiore” in Milan, Italy. METHODS: One hundred patients with newly diagnosed, histologically confirmed GBM were submitted to concomitant chemo-radiation therapy. Subjects who were not able to complete the concomitant phase of chemo-radiation therapy were excluded from this study.The diagnosis was obtained after surgical resection or stereotactic biopsy and then all the patients were treated with radiationtherapy plus continuous daily temozolomide (TMZ) according to a modified Stupp's schedule. In the adjuvant phase we administered a modified schedule consisting of 150mg/mq of TMZ, from day 1 to 5 and 75 mg/mq of TMZ from day 6 to 10 for 12 cycles instead of the 6 standard cycles proposed by Stupp and Colleagues. At recurrence, various strategies were chosen according the patients clinical and radiological status. After the concomitant phase, patients underwent a regular follow-up with a clinical examination and a brain MRI with gadolinium every 3 months. MGMT status was assessed according the method described by Hegi et al. in 2005 and was retrospectively re-evaluated with PCR real time (Pyromark Q96ID System). RESULTS: One hundred patients affected by GBM were included (60 males; 40 females; median age 61). The median KPS at presentation was 70 (range= 40- 100) which remained stable after 6 months. Median Ki67 was 10%. In 63 patients MGMT was methylated (38 males; 25 females. Median TTP-1 was of 12 months) and in 32 patients were MGMT un-methylated (male 21; females11; median TTP-1 of 9 months); in 5

  14. Innovative Hypofractionated Stereotactic Regimen Achieves Excellent Local Control with No Radiation Necrosis: Promising Results in the Management of Patients with Small Recurrent Inoperable GBM.

    Science.gov (United States)

    Jia, Angela; Pannullo, Susan C; Minkowitz, Shlomo; Taube, Shoshana; Chang, Jenghwa; Parashar, Bhupesh; Christos, Paul; Wernicke, A Gabriella

    2016-01-01

    Management of recurrent glioblastoma multiforme (GBM) remains a challenge. Several institutions reported that a single fraction of ≥ 20 Gy for small tumor burden results in excellent local control; however, this is at the expense of a high incidence of radiation necrosis (RN). Therefore, we developed a hypofractionation pattern of 33 Gy/3 fractions, which is a radiobiological equivalent of 20 Gy, with the aim to lower the incidence of RN. We reviewed records of 21 patients with recurrent GBM treated with hypofractionated stereotactic radiation therapy (HFSRT) to their 22 respective lesions. Sixty Gy fractioned external beam radiotherapy was performed as first-line treatment. Median time from primary irradiation to HFSRT was 9.6 months (range: 3.1 - 68.1 months). In HFSRT, a median dose of 33 Gy in 11 Gy fractions was delivered to the 80% isodose line that encompassed the target volume. The median tumor volume was 1.07 cm3 (range: 0.11 - 16.64 cm3). The median follow-up time after HFSRT was 9.3 months (range: 1.7 - 33.6 months). Twenty-one of 23 lesions treated (91.3%) achieved local control while 2/23 (8.7%) progressed. Median time to progression outside of the treated site was 5.2 months (range: 2.2 - 9.6 months). Progression was treated with salvage chemotherapy. Five of 21 patients (23.8%) were alive at the end of this follow-up; two patients remain disease-free. The remaining 16/21 patients (76.2%) died of disease. Treatment was well tolerated by all patients with no acute CTC/RTOG > Grade 2. There was 0% incidence of RN. A prospective trial will be underway to validate these promising results. PMID:27096136

  15. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined all- and auto-immune tumor reactivity

    NARCIS (Netherlands)

    Schijns, V.E.J.C.; Pretto, C.; Devillers, L.; Pierre, D.; Hofman, F.M.; Chen, T.C.; Mespouille, P.; Hantos, P.; Glorieux, P.; Bota, D.A.; Stathopolous, A.

    2015-01-01

    Glioblastoma multiforme (GBM) patients have a poor prognosis. After tumor recurrence statistics suggestan imminent death within 1–4.5 months. Supportive preclinical data, from a rat model, provided therational for a prototype clinical vaccine preparation, named Gliovac (or ERC 1671) composed of auto

  16. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Simpler forex rules According to the State Administration of Foreign Exchange,China began a trial program for simplifying the procedures for passing foreign currencies between banks and companies in the trading of goods.Effective from December 1,the new rules don’t require verification for information about prepayments for goods,payment cancellations or delays.

  17. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    3 More competitive According to the Global Competitiveness Report 2011-12,China’s competitiveness ranking rose from 27th to 26th among 142 economies in the world this year, continuing to lead the way among large developing economies.The report said China is one of the world’s least indebted countries,boasts a savings rate of some 53 percent of GDP,and runs only moder ate budget deficits.However,China’s fairly poor results in the financial market development and technological readiness pillars pull down its overall competitiveness performance,said the report.

  18. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Benefits for Africa China’s investments in Africa have brought multiple benefits to the continent, providing better livelihood,more development opportunities and more choices for local people,said Liu Guijin, China’s special envoy on African affairs,at the end of the three-day World Economic Forum on Africa.He said China’s investments cater to Africa’s needs for a

  19. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    RMB trade The Bank of China has opened trading in the yuan currency to U.S.customers. The bank’s New York Branch now lets companies and individuals buy and sell the yuan through accounts with its U.S. branches,although U.S.businesses and individuals can also trade the currency through Western banks.The bank said it offers yuan savings,demand deposit and time deposit accounts to business customers in New York and Los Angeles. A savings account requires a minimum balance of the equivalent of $5,000.

  20. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Pollution saver Pilot programs promoting the use of controlled-release fertilizer have been expanded to more than 20 provinces in China,compared with five in 2008,said the National Agro-Tech Extension and Service Center(NAESC),a department under the Ministry of Agriculture.The move is aimed at reducing pollution caused by the excessive use of fertilizer to protect the environment and save energy,the NAESC said.NAESC also predicted the use of controlled-release fertilizer could help increase agricultural production by 5 to 10 percent on average.

  1. A randomised, double-masked phase III/IV study of the efficacy and safety of Avastin® (Bevacizumab intravitreal injections compared to standard therapy in subjects with choroidal neovascularisation secondary to age-related macular degeneration: clinical trial design

    Directory of Open Access Journals (Sweden)

    Bunce Catey

    2008-10-01

    Full Text Available Abstract Background The management of neovascular age-related macular degeneration (nAMD has been transformed by the introduction of agents delivered by intravitreal injection which block the action of vascular endothelial growth factor-A (anti-VEGF agents. One such agent in widespread use is bevacizumab which was initially developed for use in oncology. Most of the evidence supporting the use of bevacizumab for nAMD has come from interventional case series and this clinical trial was initiated because of the increasing and widespread use of this agent in the treatment of nAMD (an off-label indication despite a lack of definitive unbiased safety and efficacy data. Methods and design The Avastin® (bevacizumab for choroidal neovascularisation (ABC trial is a double-masked randomised controlled trial comparing intravitreal bevacizumab injections to standard therapy in the treatment of nAMD. Patients are randomised to intravitreal bevacizumab or standard therapy available at the time of trial initiation (verteporfin photodynamic therapy, intravitreal pegaptanib or sham treatment. Ranibizumab treatment was not included in the control arm as it had not been licensed for use at the start of recruitment for this trial. The primary outcome is the proportion of patients gaining ≥ 15 letters of visual acuity at 1 year and secondary outcomes include the proportion of patients with stable vision and mean visual acuity change. Discussion The ABC Trial is the first double-masked randomised control trial to investigate the efficacy and safety of intravitreal bevacizumab in the treatment of nAMD. This trial fully recruited in November 2007 and results should be available in early 2009. Important design issues for this clinical trial include (a defining the control group (b use of gain in vision as primary efficacy end-point and (c use of pro re nata treatment using intravitreal bevacizumab rather than continuous therapy. Trial registration Current controlled

  2. My brief history. 2. ed.

    International Nuclear Information System (INIS)

    For the first time, Stephen Hawking turns his gaze inward for a revealing look at his own life and intellectual evolution. My Brief History recounts Stephen Hawking's improbable journey, from his post-war London boyhood to his years of international acclaim and celebrity. Illustrated with rarely seen photographs, this concise, witty and candid account introduces readers to the inquisitive schoolboy whose classmates nicknamed him 'Einstein'; the jokester who once placed a bet with a colleague over the existence of a black hole; and the young husband and father striving to gain a foothold in the world of academia. Writing with humility and humour, Hawking opens up about the challenges that confronted him following his diagnosis of ALS aged twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time - one of the iconic books of the twentieth century.

  3. Sustainable Markets Investment Briefings: Investment Treaties

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the second of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 2 explains how investment treaties between states work to protect and promote foreign investment.

  4. Continuous Briefing and User Participation in Building Projects

    OpenAIRE

    Jensen, Per Anker

    2006-01-01

    Briefing is not just about specifying needs as requirements but also about evaluating how well design pro-posals fulfill the needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the pre-project stage to create a basis for the project decision. It includes an initial strategic brief-ing to define the overall vision and objectives. Parallel to the design briefing it is necessary to carry out a briefing process related to interior design and building...

  5. Institutional Advancement Brief, Communicating NPS Value

    OpenAIRE

    Haska, Christine

    2012-01-01

    Naval Postgraduate School Institutional Advancement Brief, Communicating NPS Value. NPS Board of Advisors, April 2012, Presented by Dr. Christine Haska, Vice President for Information Resources and CIO.

  6. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Pajonk, F; Kaprealian, T; Kupelian, P; Steinberg, M; Low, D; Sheng, K [Department of Radiation Oncology, UCLA, Los Angeles, CA (United States)

    2015-06-15

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×10{sup 7}, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 10{sup 9} cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work

  7. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    International Nuclear Information System (INIS)

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×107, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 109 cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work is supported

  8. A brief history of videogames

    Directory of Open Access Journals (Sweden)

    Simone Belli

    2008-11-01

    Full Text Available The following text contains a brief journey through a short and yet intense adventure, the history of videogames. Since its beginnings in the 1950's decade to the present time, videogames have progressively changed from a hobby for ingeneering studens to the most powerfull leisure industry. In order to gain a better understanding of this phenomenon it is necessary to look over the path of its transformation from a retrospecive point of view. Such a look has necessarily to focus on those devices and games that had made a landmark in the history of videogames, taking them to their current position. Besides, it is crucial to address their implications in contemporary visual culture, along with current prejudices against them. This is a short account about a great history.

  9. UNESCO Policy Briefs on Early Childhood, 2002.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Early Childhood and Family Education Unit.

    This document consists of eight double-sided briefs addressing aspects of the field of early childhood education. Titles of the briefs are as follows: (1) "Early Childhood Care? Development? Education?," outlining the distinctions between these terms; (2) "Planning for Access: Develop a Data System First," highlighting Brazil's census to collect…

  10. Negotiating Visualities in Briefing and Design

    DEFF Research Database (Denmark)

    Koch, Christian; Bendixen, Mads

    2007-01-01

    Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations are...... approaches should be chosen to promote innovative briefing and design....

  11. Brief Psychotherapy Methods in Clinical Research.

    Science.gov (United States)

    Koss, Mary P.; And Others

    1986-01-01

    After a concise overview of the technical characteristics that define brief psychotherapy, the current use and misuse of these methods in clinical research on the outcome and process of treatment is examined. Suggests that brief psychotherapy methods possess unique technical advantages to the researcher. (Author/BL)

  12. Internship or Indenture? Research Brief. Edition 2

    Science.gov (United States)

    Sutton Trust, 2014

    2014-01-01

    This brief analyzes the latest higher education data and government wage statistics to examine the number of unpaid graduate interns in the United Kingdom and the cost to an individual of doing an unpaid internship. It also includes newly published Ipsos Mori polling on attitudes to unpaid internships. Key findings in this brief include: (1) 31%…

  13. 76 FR 50715 - Briefing on Partner Vetting System Pilot Program

    Science.gov (United States)

    2011-08-16

    ...; ] DEPARTMENT OF STATE Agency for International Development Briefing on Partner Vetting System Pilot Program... briefing. SUMMARY: Notice is hereby given of a briefing on the Partner Vetting System (PVS) pilot...

  14. NASA Tech Briefs, February 2009

    Science.gov (United States)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: Measuring Low Concentrations of Liquid Water in Soil; The Mars Science Laboratory Touchdown Test Facility; Non-Contact Measurement of Density and Thickness Variation in Dielectric Materials; Compact Microwave Fourier Spectrum Analyzer; InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz; Combinatorial Generation of Test Suites; In-Phase Power-Combined Frequency Tripler at 300 GHz; Electronic System for Preventing Airport Runway Incursions; Smaller but Fully Functional Backshell for Cable Connector; Glove-Box or Desktop Virtual-Reality System; Composite Layer Manufacturing with Fewer Interruptions; Improved Photoresist Coating for Making CNT Field Emitters; A Simplified Diagnostic Method for Elastomer Bond Durability; Complex Multifunctional Polymer/Carbon-Nanotube Composites; Very High Output Thermoelectric Devices Based on ITO Nanocomposites; Reducing Unsteady Loads on a Piggyback Miniature Submarine; Ultrasonic/Sonic Anchor; Grooved Fuel Rings for Nuclear Thermal Rocket Engines; Pulsed Operation of an Ion Accelerator; Autonomous Instrument Placement for Mars Exploration Rovers; Mission and Assets Database; TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP); Trajectory Calculator for Finite-Radius Cutter on a Lathe; Integrated System Health Management Development Toolkit.

  15. Engineering Technical Review Planning Briefing

    Science.gov (United States)

    Gardner, Terrie

    2012-01-01

    The general topics covered in the engineering technical planning briefing are 1) overviews of NASA, Marshall Space Flight Center (MSFC), and Engineering, 2) the NASA Systems Engineering(SE) Engine and its implementation , 3) the NASA Project Life Cycle, 4) MSFC Technical Management Branch Services in relation to the SE Engine and the Project Life Cycle , 5) Technical Reviews, 6) NASA Human Factor Design Guidance , and 7) the MSFC Human Factors Team. The engineering technical review portion of the presentation is the primary focus of the overall presentation and will address the definition of a design review, execution guidance, the essential stages of a technical review, and the overall review planning life cycle. Examples of a technical review plan content, review approaches, review schedules, and the review process will be provided and discussed. The human factors portion of the presentation will focus on the NASA guidance for human factors. Human factors definition, categories, design guidance, and human factor specialist roles will be addressed. In addition, the NASA Systems Engineering Engine description, definition, and application will be reviewed as background leading into the NASA Project Life Cycle Overview and technical review planning discussion.

  16. Elliptic flow: a brief review

    Science.gov (United States)

    Snellings, Raimond

    2011-05-01

    One of the fundamental questions in the field of subatomic physics is the question of what happens to matter at extreme densities and temperatures as may have existed in the first microseconds after the Big Bang and exists, perhaps, in the core of dense neutron stars. The aim of heavy-ion physics is to collide nuclei at very high energies and thereby create such a state of matter in the laboratory. The experimental program began in the 1990s with collisions made available at the Brookhaven Alternating Gradient Synchrotron (AGS) and the CERN Super Proton Synchrotron (SPS), and continued at the Brookhaven Relativistic Heavy-Ion Collider (RHIC) with the maximum center-of-mass energies of \\sqrt{s_{NN}} = 4.75 , 17.2 and 200 GeV, respectively. Collisions of heavy ions at the unprecedented energy of 2.76 TeV recently became available at the LHC collider at CERN. In this review, I give a brief introduction to the physics of ultrarelativistic heavy-ion collisions and discuss the current status of elliptic flow measurements.

  17. Sustainable Markets Investment Briefings: Foreign investment contracts

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fourth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 4 sets out some of the ways in which foreign investment contracts can impact on sustainable development.

  18. Sustainable Markets Investment Briefings: International arbitration

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fifth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 5 explains how international arbitration works to resolve disputes between foreign investors and host states, and outlines some of the problems associated with its use, from a sustainable development perspective.

  19. NASA Tech Briefs, February 2012

    Science.gov (United States)

    2012-01-01

    This issue contains the following briefs: (1) Optical Comb from a Whispering Gallery Mode Resonator for Spectroscopy and Astronomy Instruments Calibration (2) Real-Time Flight Envelope Monitoring System (3) Nemesis Autonomous Test System (4) Mirror Metrology Using Nano-Probe Supports (5) Automated Lab-on-a-Chip Electrophoresis System (6) Techniques for Down-Sampling a Measured Surface Height Map for Model Validation (7) Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter (8) Frequency to Voltage Converter Analog Front-End Prototype (9) Dust-Tolerant Intelligent Electrical Connection System (10) Gigabit Ethernet Asynchronous Clock Compensation FIFO (11) High-Speed, Multi-Channel Serial ADC LVDS Interface for Xilinx Virtex-5 FPGA (12) Glovebox for GeoLab Subsystem in HDU1-PEM (13) Modified Process Reduces Porosity when Soldering in Reduced Gravity Environments (14) Use of Functionalized Carbon Nanotubes for Covalent Attachment of Nanotubes to Silicon (15) Flexible Plug Repair for Shuttle Wing Leading Edge (16) Three Dimensionally Interlinked, Dense, Solid Form of Single-Walled CNT Ropes (17) Axel Robotic Platform for Crater and Extreme Terrain Exploration (18) Site Tamper and Material Plow Tool - STAMP (19) Magnetic Interface for Segmented Mirror Assembly (20) Transpiration-Cooled Spacecraft-Insulation-Repair Fasteners (21) Fluorescence-Based Sensor for Monitoring Activation of Lunar Dust (22) Aperture Ion Source (23) Virtual Ultrasound Guidance for Inexperienced Operators (24) Model-Based Fault Diagnosis: Performing Root Cause and Impact Analyses in Real Time (25) Interactive Schematic Integration Within the Propellant System Modeling Environment (26) Magnetic and Electric Field Polarizations of Oblique Magnetospheric Chorus Waves (27) Variable Sampling Mapping.

  20. Brief Review on the Relevance Theory

    Institute of Scientific and Technical Information of China (English)

    龚腾龙; 阿勒腾

    2015-01-01

    Relevance theory has had an impact on the study in various disciplines including linguistics,literature and so on. This paper gives a brief review of the relevance theory and two principles of relevance.

  1. Briefing statement : Waubay Wetland Management District

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This briefing statement details the Waubay National Wildlife Refuge, staff, funding, history, refuges facts and maps, general management, public use and depredation...

  2. CONVENTIONAL COMBUSTION ENVIRONMENTAL ASSESSMENT PROGRAM, EXECUTIVE BRIEFING

    Science.gov (United States)

    The brochure gives an executive briefing of EPA's Conventional Combustion Environmental Assessment (CCEA) Program. The CCEA Program was established recently to coordinate and integrate EPA's research and development efforts for assessing the environmental effects of pollutants fr...

  3. Pulsed low-dose irradiation of orthotopic glioblastoma multiforme (GBM) in a pre-clinical model: Effects on vascularization and tumor control

    International Nuclear Information System (INIS)

    Background and purpose: To compare dose-escalated pulsed low-dose radiation therapy (PLRT) and standard radiation therapy (SRT). Methods and materials: Intracranial U87MG GBM tumors were established in nude mice. Animals received whole brain irradiation with daily 2-Gy fractions given continuously (SRT) or in ten 0.2-Gy pulses separated by 3-min intervals (PLRT). Tumor response was evaluated using weekly CT and [18F]-FDG-PET scans. Brain tissue was subjected to immunohistochemistry and cytokine bead array to assess tumor and normal tissue effects. Results: Median survival for untreated animals was 18 (SE ± 0.5) days. A significant difference in median survival was seen between SRT (29 ± 1.8 days) and PLRT (34.2 ± 1.9 days). Compared to SRT, PLRT resulted in a 31% (p < 0.01), 38% (p < 0.01), and 53% (p = 0.01) reduction in normalized tumor volume and a 48% (p < 0.01), 51% (p < 0.01), and 70% (p < 0.01) reduction in tumor growth rate following the administration of 10 Gy, 20 Gy, and 30 Gy, respectively. Compared to untreated tumors, PLRT resulted in similar tumor vascular density, while SRT produced a 40% reduction in tumor vascular density (p = 0.05). Compared to SRT, PLRT was associated with a 28% reduction in degenerating neurons in the surrounding brain parenchyma (p = 0.05). Conclusions: Compared to SRT, PLRT resulted in greater inhibition of tumor growth and improved survival, which may be attributable to preservation of vascular density

  4. The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.

    Directory of Open Access Journals (Sweden)

    Janice A Royds

    Full Text Available Prognostic markers for glioblastoma multiforme (GBM are important for patient management. Recent advances have identified prognostic markers for GBMs that use telomerase or the alternative lengthening of telomeres (ALT mechanism for telomere maintenance. Approximately 40% of GBMs have no defined telomere maintenance mechanism (NDTMM, with a mixed survival for affected individuals. This study examined genetic variants in the cyclin-dependent kinase inhibitor 2A (CDKN2A gene that encodes the p16(INK4a and p14(ARF tumor suppressors, and the isocitrate dehydrogenase 1 (IDH1 gene as potential markers of survival for 40 individuals with NDTMM GBMs (telomerase negative and ALT negative by standard assays, 50 individuals with telomerase, and 17 individuals with ALT positive tumors. The analysis of CDKN2A showed NDTMM GBMs had an increased minor allele frequency for the C500G (rs11515 polymorphism compared to those with telomerase and ALT positive GBMs (p = 0.002. Patients with the G500 allele had reduced survival that was independent of age, extent of surgery, and treatment. In the NDTMM group G500 allele carriers had increased loss of CDKN2A gene dosage compared to C500 homozygotes. An analysis of IDH1 mutations showed the R132H mutation was associated with ALT positive tumors, and was largely absent in NDTMM and telomerase positive tumors. In the ALT positive tumors cohort, IDH1 mutations were associated with a younger age for the affected individual. In conclusion, the G500 CDKN2A allele was associated with NDTMM GBMs from older individuals with poorer survival. Mutations in IDH1 were not associated with NDTMM GBMs, and instead were a marker for ALT positive tumors in younger individuals.

  5. Environmental actual situation in Guatemala. Executive brief

    International Nuclear Information System (INIS)

    In this brief prepared by the Consejo Permanente de Cambio y Variabilidad Climatica the climate in Guatemala is described including the current situation on variation of rainy season, air humidity, influence of the Nino current. This brief was prepared in order to plan a strategy to be adopted by all the institutions that are involved in environmental issues and in this way to deal with the climate change and the impact of the different energy sources in the environment

  6. Urban Teacher Retention Policy: A Research Brief

    OpenAIRE

    Quartz, Karen Hunter; Kimberly Barraza Lyons; Katherine Masyn; Brad Olsen; Lauren Anderson; Andrew Thomas; Joanna Goode; Eileen Lai Horng

    2004-01-01

    This research brief summarizes interim results from a longitudinal study designed to inform policies aimed at curbing the high rate of attrition from hard-to-staff urban schools. These policies range from ensuring specialized teacher preservice education that willthat will prepare teachers for the challenges ahead to ongoing support for professional development and advancement. As an initial step in assessing the impact of specialized urban teacher preparation on retention, the research brief...

  7. Intravitreal Bevacizumab (Avastin for Diabetic Retinopathy: The 2010 GLADAOF Lecture

    Directory of Open Access Journals (Sweden)

    J. Fernando Arevalo

    2011-01-01

    Full Text Available This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB on diabetic retinopathy (DR including diabetic macular edema (DME and proliferative diabetic retinopathy (PDR at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of 1.25 or 2.5 mg of bevacizumab for DME, PDR without tractional retinal detachment (TRD, and patients who experienced the development or progression of TRD after an intravitreal injection of 1.25 or 2.5 mg of bevacizumab before vitrectomy for the management of PDR. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA in diffuse DME. Therefore, in the future this new therapy could complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to panretina photocoagulation so that more selective therapy may be applied. Finally, TRD in PDR may occur or progress after IVB used as an adjuvant to vitrectomy. Surgery should be performed 4 days after IVB. Most patients had poorly controlled diabetes mellitus associated with elevated HbA1c, insulin administration, PDR refractory to panretinal photocoagulation, and longer time between IVB and vitrectomy.

  8. Intravitreal Bevacizumab (Avastin) for Diabetic Retinopathy: The 2010 GLADAOF Lecture

    OpenAIRE

    Virgilio Morales-Canton; Jans Fromow-Guerra; Michel Eid Farah; Maria H. Berrocal; Mario Saravia; Natalia Restrepo; Arturo A. Alezzandrini; Sergio Bonafonte; Miguel Brito; Lihteh Wu; Mauricio Maia; Andres F. Lasave; Sanchez, Juan G.; J. Fernando Arevalo

    2011-01-01

    This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB) on diabetic retinopathy (DR) including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of 1.25 or 2.5 mg of bevacizumab for DME, PDR without tractional retinal detachment (TRD), and patients who experienced the development or progression of TRD after an intravitreal ...

  9. Use of ERC-1671 vaccine in a patient with recurrent glioblastoma multiforme after progression during bevacizumab therapy: first published report

    NARCIS (Netherlands)

    Bota, D.A.; Alexandru-Abrams, D.; Pretto, C.; Hofman, F.M.; Chen, T.C.; Fu, B.; Carrillo, J.A.; Schijns, V.E.J.C.; Stathopoulos, A.

    2015-01-01

    Objectives: Glioblastoma multiforme (GBM) is a highly aggressive tumor, which recurs despite resection, focal beam radiation, and temozolomide chemotherapy. At recurrence, the only second-line treatment approved by the US Food and Drug Administration is bevacizumab (Avastin). To date, no single agen

  10. Impacts of climate change and socio-economic scenarios on flow and water quality of the Ganges, Brahmaputra and Meghna (GBM) river systems: low flow and flood statistics.

    Science.gov (United States)

    Whitehead, P G; Barbour, E; Futter, M N; Sarkar, S; Rodda, H; Caesar, J; Butterfield, D; Jin, L; Sinha, R; Nicholls, R; Salehin, M

    2015-06-01

    The potential impacts of climate change and socio-economic change on flow and water quality in rivers worldwide is a key area of interest. The Ganges-Brahmaputra-Meghna (GBM) is one of the largest river basins in the world serving a population of over 650 million, and is of vital concern to India and Bangladesh as it provides fresh water for people, agriculture, industry, conservation and for the delta system downstream. This paper seeks to assess future changes in flow and water quality utilising a modelling approach as a means of assessment in a very complex system. The INCA-N model has been applied to the Ganges, Brahmaputra and Meghna river systems to simulate flow and water quality along the rivers under a range of future climate conditions. Three model realisations of the Met Office Hadley Centre global and regional climate models were selected from 17 perturbed model runs to evaluate a range of potential futures in climate. In addition, the models have also been evaluated using socio-economic scenarios, comprising (1) a business as usual future, (2) a more sustainable future, and (3) a less sustainable future. Model results for the 2050s and the 2090s indicate a significant increase in monsoon flows under the future climates, with enhanced flood potential. Low flows are predicted to fall with extended drought periods, which could have impacts on water and sediment supply, irrigated agriculture and saline intrusion. In contrast, the socio-economic changes had relatively little impact on flows, except under the low flow regimes where increased irrigation could further reduce water availability. However, should large scale water transfers upstream of Bangladesh be constructed, these have the potential to reduce flows and divert water away from the delta region depending on the volume and timing of the transfers. This could have significant implications for the delta in terms of saline intrusion, water supply, agriculture and maintaining crucial ecosystems such

  11. Competency-Based Business Degree. Issue Brief

    Science.gov (United States)

    Washington State Board for Community and Technical Colleges, 2014

    2014-01-01

    In January 2015, thirteen Washington community colleges launched an online, competency-based business transfer degree--the first in the state's community and technical college system. This issue brief provides answers to commonly asked questions about the new competency-based degree.

  12. A Brief Introduction to SLA Theories

    Institute of Scientific and Technical Information of China (English)

    佘阿莉

    2015-01-01

    There are a large number of theories,models or hypotheses in the history of SLA research.A brief introduction is made in this paper on several typical ones which have a great influence on foreign language teaching and it is hoped to be useful for the study of SLA research and foreign language teaching.

  13. Genre Identification of Very Brief Musical Excerpts

    Science.gov (United States)

    Mace, Sandra T.; Wagoner, Cynthia L.; Teachout, David J.; Hodges, Donald A.

    2012-01-01

    The purpose of this study was to examine how well individuals were able to identify different music genres from very brief excerpts and whether musical training, gender and preference played a role in genre identification. Listeners were asked to identify genre from classical, jazz, country, metal, and rap/hip hop excerpts that were 125, 250, 500,…

  14. Monitoring Climate Finance and ODA Issues Brief

    OpenAIRE

    Huhtala, Ari; Curto, Stefano; Ambrosi, Philippe

    2010-01-01

    This issues brief examines the challenges of monitoring financial flows related to climate change. The first part focuses on tracking, monitoring, and reporting various types of flows, primarily from official development assistance (ODA) and other public sources but also from private sources. The second part explores possible ways of tracking additionality in ODA flows, with the aim of sti...

  15. Quality Physical Education. NASPE Resource Brief

    Science.gov (United States)

    National Association for Sport and Physical Education, 2013

    2013-01-01

    A quality physical education program provides learning opportunities, appropriate instruction, meaningful and challenging content, and student and program assessment. In addition, a quality physical education improves mental alertness, academic performance, and readiness and enthusiasm for learning in the nation's youth. This brief provides a list…

  16. 14 CFR 91.519 - Passenger briefing.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Passenger briefing. 91.519 Section 91.519 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... be supplemented by printed cards for the use of each passenger containing— (1) A diagram of,...

  17. A brief history of the universe

    International Nuclear Information System (INIS)

    The failure of the Big Bang Theory to explain the experimental (cosmological) data is well known. Attempts have been made to give a new interpretation of the above theory to explain the existing cosmological problems and a brief history of the universe. (author). 2 refs, 1 fig

  18. Attention Deficit Disorder. NICHCY Briefing Paper.

    Science.gov (United States)

    Fowler, Mary

    This briefing paper uses a question-and-answer format to provide basic information about children with attention deficit disorder (ADD). Questions address the following concerns: nature and incidence of ADD; causes of ADD; signs of ADD (impulsivity, hyperactivity, disorganization, social skill deficits); the diagnostic ADD assessment; how to get…

  19. Update: Preparation Briefing Meeting for Shanghai

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ On March 9,the preparation briefing meeting for Shanghai World Expo was held in Beijing.Shanghai Mayor Han Zheng,CCPIT Chairman Wan Jifei,Assistant Foreign Minister Liu Jieyi and three deputy directors of Shanghai World Expo Organizing Committee addressed the meeting.

  20. Sustainable investment in Turkey: issue brief

    OpenAIRE

    Ararat, Melsa; Yurtoğlu, Burçin B.; Yurtoglu, Burcin B.; Suel, Esra

    2011-01-01

    IFC launched a series of sustainable investment country reports initially covering the largest emerging capital markets attracting global portfolio investors: Brazil, India, and China. Further reports have been added to the series covering Sub-Saharan Africa, the Middle East and North Africa, and Turkey. This Issue Brief 's the summary version of the report, “Sustainable Investment in Turkey,”

  1. A brief history of dosage compensation

    Indian Academy of Sciences (India)

    Stanley M. Gartler

    2014-08-01

    In 1914, H. J. Muller postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.

  2. Universities and Development: Global Cooperation. Policy Briefing

    Science.gov (United States)

    Universities UK, 2010

    2010-01-01

    This policy briefing aims to demonstrate that universities are key organisations in international development. Universities are involved in a wide range of international development activities, including collaborative research projects, developing entrepreneurial and employability skills and the evaluation of non-governmental organisation (NGO)…

  3. A brief review on nuclear fragmentation

    International Nuclear Information System (INIS)

    In this article a brief review on nuclear fragmentation has been presented on both theoretical and experimental ground. On the theoretical aspects discussion on different models has been done. On experimental overview the multiplicity distribution, angular distribution, correlation and intermittent type of fluctuations have been discussed for black and grey particles is presented. An experimental review on projectile fragments is also given. (author)

  4. The Neighboring Field of Brief Individual Psychotherapy.

    Science.gov (United States)

    Gustafson, Jim

    1987-01-01

    Presents field of brief individual psychotherapy as coherent set of conventions, despite its diverse origins in schools of dynamic, behavioral, interpersonal or cognitive, and strategic psychotherapy. Proposes advantages and drawbacks of shared conventions and discusses how neighboring field could help field of family therapy reduce its errors.…

  5. Counseling Services and Student Success. Research Brief

    Science.gov (United States)

    Francis, Perry C.; Horn, Aaron S.

    2016-01-01

    The purpose of this research brief is to provide an overview of mental health issues and counseling services on college campuses. The findings from several national surveys are reviewed to estimate the prevalence of anxiety and depression, suicide and suicidal ideation, and violence among college students. Common prevention and treatment programs…

  6. Reinventing Teacher Compensation Systems. CPRE Finance Briefs.

    Science.gov (United States)

    Kelley, Carolyn; Odden, Allan

    Other organizations in the United States have successfully implemented new compensation structures. This publication argues that it is time for education to join these successful efforts and revise teacher-pay systems. The brief provides a short history of changes in teacher compensation over the last century and a discussion of key organizational…

  7. NASA Ames Fluid Mechanics Laboratory research briefs

    Science.gov (United States)

    Davis, Sanford (Editor)

    1994-01-01

    The Ames Fluid Mechanics Laboratory research program is presented in a series of research briefs. Nineteen projects covering aeronautical fluid mechanics and related areas are discussed and augmented with the publication and presentation output of the Branch for the period 1990-1993.

  8. Briefs for English-Speaking Parents, 1996.

    Science.gov (United States)

    Howley, Craig

    In plain language, these six ready-to-copy briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. "Calculating the Risks: When Should Parents Add or Subtract?" discusses the normal risks of life, the intensification of risk by poverty, and how parents can keep children…

  9. Characteristics of Improved School Districts. Research Brief

    Science.gov (United States)

    Center for Comprehensive School Reform and Improvement, 2006

    2006-01-01

    This research brief presents an overview of a 2004 study by G.S. Shannon and P. Bylsma entitled "Characteristics of Improved School Districts: Themes from Research" (Olympia, WA: Office of Superintendent of Public Instruction). The authors reviewed more than 80 research articles that investigated the attributes of schools and districts that have…

  10. Pseudoangiomatous stromal hyperplasia (PASH): a brief review.

    Science.gov (United States)

    Jaunoo, S S; Thrush, S; Dunn, P

    2011-01-01

    Pseudoangiomatous stromal hyperplasia (PASH) is a benign entity of the breast and typically found incidentally. It warrants thorough investigation in order to exclude more sinister pathology masquerading as this form of benign breast disease and can often be managed expectantly without the need for surgical intervention. We provide a brief review of the literature on PASH, discussing its clinicopathological features and management. PMID:20887819

  11. Luminosity and spin-period evolution of GX 304-1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    Science.gov (United States)

    Sugizaki, Mutsumi; Yamamoto, Takayuki; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-08-01

    A report is made on the luminosity and pulse period evolution of the Be binary X-ray pulsar GX 304-1 during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, 12 outbursts repeated by ˜ 132.2 d were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were all found to recur with a well-defined period of 132.189 ± 0.02 d, which can be identified with the orbital period. The pulse period of ˜ 275 s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital elements obtained from the best-fit model, including the projected orbital semi-major axis ax sin i ≃ 500-600 light-s and an eccentricity e ≃ 0.5, are typical of Be binary X-ray pulsars.

  12. Luminosity and spin-period evolution of GX 304$-$1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-01-01

    A report is made on the luminosity and pulse-period evolution of the Be binary X-ray pulsar, GX 304$-$1, during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, twelve outbursts repeated by $\\sim$ 132.2 days were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were found to all recur with a well defined period of 132.189$\\pm$0.02 d, which can be identified with the orbital period. The pulse period at $\\sim 275$ s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse-period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital element...

  13. Citizens Science for Sustainability (SuScit) Project Briefing

    DEFF Research Database (Denmark)

    Eames, Malcolm; Mortensen, Jonas Egmose; Adebowale, Maria;

    This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project.......This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project....

  14. ETV Tech Brief: Rapid Fungi and Bacteria Detection Technologies

    Science.gov (United States)

    Technical brief that summarizes the results for Mycometer, Inc. Mycometer®-test and Bactiquant®-test, which are rapid detection technologies for fungi and bacteria. The brief summarizes the results of the verification report and statement.

  15. 14 CFR 135.117 - Briefing of passengers before flight.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Briefing of passengers before flight. 135... Flight Operations § 135.117 Briefing of passengers before flight. (a) Before each takeoff each pilot in... briefing shall include a statement that the Federal Aviation Regulations require passenger compliance...

  16. 14 CFR 141.43 - Pilot briefing areas.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot briefing areas. 141.43 Section 141.43... Pilot briefing areas. (a) An applicant for a pilot school certificate or provisional pilot school certificate must show that the applicant has continuous use of a briefing area located at each airport...

  17. 14 CFR 125.327 - Briefing of passengers before flight.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Briefing of passengers before flight. 125... § 125.327 Briefing of passengers before flight. (a) Before each takeoff, each pilot in command of an... briefing shall include a statement that the Federal Aviation Regulations require passenger compliance...

  18. 14 CFR 121.573 - Briefing passengers: Extended overwater operations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Briefing passengers: Extended overwater... OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.573 Briefing passengers: Extended overwater operations. (a) In addition to the oral briefing required by §...

  19. On the Integration of Science and Practice in Brief Psychotherapy.

    Science.gov (United States)

    May, Robert

    1992-01-01

    Responds to previous article by Steenbarger on science-practice integration in brief counseling and therapy. Focuses specifically on the integration of science and practice in brief psychotherapy. Elaborates on agreements and disagreements concerning Steenbarger's analysis of brief psychotherapy. Muses over what is lost as well as gained in brief…

  20. Solution-Focused Brief Therapy: Helpful Interventions for School Counselors.

    Science.gov (United States)

    Bonnington, Stuart B.

    1993-01-01

    Notes that school counselors have routinely practiced brief forms of counseling. Contends that solution-focused brief therapy offers counselors numerous straight forward interventions that can help counselors focus on clients' strengths to find meaningful solutions to problems. Presents solution-focused brief therapy framework and identifies tasks…

  1. Cosmology today-A brief review

    CERN Document Server

    Cervantes-Cota, Jorge L

    2011-01-01

    This is a brief review of the standard model of cosmology. We first introduce the FRW models and their flat solutions for energy fluids playing an important role in the dynamics at different epochs. We then introduce different cosmological lengths and some of their applications. The later part is dedicated to the physical processes and concepts necessary to understand the early and very early Universe and observations of it.

  2. A (Very) Brief History of Artificial Intelligence

    OpenAIRE

    Buchanan, Bruce G.

    2005-01-01

    In this brief history, the beginnings of artificial intelligence are traced to philosophy, fiction, and imagination. Early inventions in electronics, engineering, and many other disciplines have influenced AI. Some early milestones include work in problems solving which included basic work in learning, knowledge representation, and inference as well as demonstration programs in language understanding, translation, theorem proving, associative memory, and knowledge-based systems. The article e...

  3. Interviewing: Methodological Briefs - Impact Evaluation No. 12

    OpenAIRE

    Patricia Rogers; Bronwen McDonald

    2014-01-01

    Interviews are easy to do badly and hard to do well - good planning, adequate time and appropriate skills are required. The type of interview should be carefully chosen to suit the situation rather than choosing a type of interview (such as focus groups) simply because it is commonly used. Interviews with children raise particular ethical issues that need to be carefully considered and fully addressed. This brief outlines key issues to consider in planning interviews for impact evaluation, ta...

  4. A brief history of topographical anatomy.

    Science.gov (United States)

    Standring, Susan

    2016-07-01

    This brief history of topographical anatomy begins with Egyptian medical papyri and the works known collectively as the Greco-Arabian canon, the time line then moves on to the excitement of discovery that characterised the Renaissance, the increasing regulatory and legislative frameworks introduced in the 18th and 19th centuries, and ends with a consideration of the impact of technology that epitomises the period from the late 19th century to the present day. This paper is based on a lecture I gave at the Winter Meeting of the Anatomical Society in Cambridge in December 2015, when I was awarded the Anatomical Society Medal. PMID:27278889

  5. 2. Der erkenntnistheoretische Grundentwurf im 7. Brief

    OpenAIRE

    Liatsi, Maria

    2014-01-01

    Der Brief ist nach Dions Tod verfaßt und richtet sich an die Verwandten und Freunde Dions, gleichzeitig richtet er sich nach Form und Inhalt an die damalige kulturelle Öffentlichkeit. Dion war aus der ihm von Dionysios II. auferlegten Verbannung zurückgekehrt und hatte, ausgerüstet mit einigen Schiffen und einem kleinen Söldnerheer, Syrakus besetzt. Das Volk jubelte ihm wie einem Retter und Befreier zu. Das war im Herbst 357 gewesen. Der Tyrann leistete bis Ende 355 in Ortygia Widerstand und ...

  6. Brief history of electronic stereoscopic displays

    Science.gov (United States)

    Lipton, Lenny

    2012-02-01

    A brief history of recent developments in electronic stereoscopic displays is given concentrating on products that have succeeded in the market place and hence have had a significant influence on future implementations. The concentration is on plano-stereoscopic (two-view) technology because it is now the dominant display modality in the marketplace. Stereoscopic displays were created for the motion picture industry a century ago, and this technology influenced the development of products for science and industry, which in turn influenced product development for entertainment.

  7. Editorial-A brief journal status update.

    Science.gov (United States)

    Lynch, James F

    2016-05-01

    In this editorial, the Editor-in-Chief of the Journal of the Acoustical Society of America gives a brief overview of the present status of the Journal, emphasizing the events that have occurred over the past one and one half years. Topics addressed include: (1) The recent transition to the Editorial Manager peer review system, (2) new features that have been implemented in the Journal, (3) the incoming Managing Editor, (4) the publications component of the Acoustical Society's Strategic Plan, (5) new and revived article types, (6) open access, and (7) Journal metrics and statistics. PMID:27250160

  8. Brief historical background of Miamisburg Indian Mound

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Lorraine M. [comp.

    1960-01-01

    The construction of Mound Laboratory was completed in 1948. The name Mound Laboratory was chosen for this installation because of the major Indian Mound which is immediately adjacent to the Plant site. Frequent inquiries of visitors to Mound Lab concerning the Indian Mounds in general and specifically Miamisburg's Indian Mound has indicated an area of "outside interest". We, therefore, thought it would be appropriate to furnish this brief historical background to all of the attendees at the Twentieth Meeting of the Mechanical Equipment Management Subgroup.

  9. Energy in Croatia 2008, Brief Report

    International Nuclear Information System (INIS)

    The sixth edition of concise energy review 'Energy in Croatia 2008' presents brief information on relations and developments in the Croatian energy sector to domestic and international audience. Apart od basic energy indicators, this report provides data on energy production and consumption, as well as energy commodities, balances for the past period. In addition, the report gives other interesting indicators, such as, basic facts on the Republic of Croatia, air pollutant emissions, energy prices, energy capacities and energy reserves. The report presents the croatian energy sector in practical and informative style

  10. A Brief Analysis on William Blake's London

    Institute of Scientific and Technical Information of China (English)

    张莉; 尚彦飞

    2014-01-01

    William Blake (1757-1827) is a renowned British poet in the 18th century. His lyric poems display the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is a well-known lyric poetry, which is thought to be the best vesicle in the West. This paper will analyse this poem in terms of its form, theme, and im-age and then draw a brief conclusion for the characteristics of William Blake's poem.

  11. The Raychaudhuri equations: A brief review

    Indian Academy of Sciences (India)

    Sayan Kar; Soumitra Sengupta

    2007-07-01

    We present a brief review on the Raychaudhuri equations. Beginning with a summary of the essential features of the original article by Raychaudhuri and subsequent work of numerous authors, we move on to a discussion of the equations in the context of alternate non-Riemannian spacetimes as well as other theories of gravity, with a special mention on the equations in spacetimes with torsion (Einstein–Cartan–Sciama–Kibble theory). Finally, we give an overview of some recent applications of these equations in general relativity, quantum field theory, string theory and the theory of relativisitic membranes. We conclude with a summary and provide our own perspectives on directions of future research.

  12. Fast healthcare: brief communication, traps and opportunities.

    Science.gov (United States)

    Crawford, Paul; Brown, Brian

    2011-01-01

    Resource considerations have meant that brevity in health care interventions is a high priority, and have led to a constant striving after ever more impressive time efficiency. The UK's National Health Service may be described as a kind of 'fast healthcare', where everyone is task busy, time is money, bed spaces are frenetically shuffled so as to accommodate the most needy and there appears to be 'no time to talk'. Indeed, a great many health care encounters are taking place in short 'blips' often of 5min or less across a range of sites and involving a vast number of practitioners. In this paper we explore how brief communication can both alienate and be therapeutic for patients. We theorise brief interactions by considering a number of traditions of work in anthropology, linguistics and sociology and conclude that health care providers need to invest much more in the skills and strategies for how best to communicate briefly if it to retain its core tradition of caring for others. PMID:20303228

  13. The Brief Norwegian Safety Climate Inventory (Brief NORSCI) – Psychometric properties and relationships with shift work, sleep, and health

    OpenAIRE

    Nielsen, Morten Birkeland; Hystad, Sigurd William; Eid, Jarle

    2015-01-01

    The aim of this study was to establish the psychometric properties of the 11-item Brief Norwegian Safety Climate Inventory (Brief NORSCI) and to examine direct and indirect associations between shift work schedules, sleep problems, health complaints, and psychological safety climate. The study was based on a questionnaire survey in a randomly drawn cross-sectional sample of 8066 workers from the Norwegian offshore petroleum industry. The results showed that the Brief NORSCI has good psychomet...

  14. Affordances for robots: a brief survey

    Directory of Open Access Journals (Sweden)

    Thomas E. Horton

    2012-12-01

    Full Text Available In this paper, we consider the influence of Gibson's affordance theory on the design of robotic agents. Affordance theory (and the ecological approach to agent design in general has in many cases contributed to the development of successful robotic systems; we provide a brief survey of AI research in this area. However, there remain significant issues that complicate discussions on this topic, particularly in the exchange of ideas between researchers in artificial intelligence and ecological psychology. We identify some of these issues, specifically the lack of a generally accepted definition of "affordance" and fundamental differences in the current approaches taken in AI and ecological psychology. While we consider reconciliation between these fields to be possible and mutually beneficial, it will require some flexibility on the issue of direct perception.

  15. Negotiating Visualities in Briefing and Design

    DEFF Research Database (Denmark)

    Koch, Christian; Bendixen, Mads

    2007-01-01

    prescription, changing their roles and configurations, and intersecting and affecting the project process in characteristic ways. Visual representations play a temporary role, and ‘time’ and ‘phase’ set boundaries for them. For practice, the analysis suggests the implication that communitarian management......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations are...... discussed. First, drawings are shown to be inscribed with particular interests, making them political instruments. Second, they have prescriptive effects as partially independent actors in the project. Third, they are shown to participate as conscriptions in a complementary process of inscription and...

  16. Negotiating Visualizations in Briefing and Design

    DEFF Research Database (Denmark)

    Bendixen, Mads; Koch, Christian

    2007-01-01

    prescription, changing their roles and configurations, and intersecting and affecting the project process in characteristic ways. Visual representations play a temporary role, and ‘time’ and ‘phase’ set boundaries for them. For practice, the analysis suggests the implication that communitarian management......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations are...... discussed. First, drawings are shown to be inscribed with particular interests, making them political instruments. Second, they have prescriptive effects as partially independent actors in the project. Third, they are shown to participate as conscriptions in a complementary process of inscription and...

  17. The Financial Therapy Association: A Brief History

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2010-10-01

    Full Text Available The purpose of this brief review is to provide a historical context for the conceptualization, development, and launch of the Financial Therapy Association (FTA. The FTA membership base consists of practicing financial planners, financial counselors, psychologists, marriage and family therapists, social workers, financial coaches, psychotherapists, and researchers from these and other disciplines. From the outset, the Association’s purpose has encompassed five goals:To promote a vision of financial therapy, which is the study of cognitive, emotional, behavioral, relational, economic, and integrative aspects of financial health.To provide a forum for researchers, practitioners, the media, and policy makers to share research and practice methods and models of financial therapy.To promote methods of training for those involved in financial therapy.To inform policy and practice management standards as these relate to financial therapy.To stimulate and disseminate clinical, experimental, and survey research on financial therapy.

  18. Brief assessment of negative dysmorphic signs

    Directory of Open Access Journals (Sweden)

    Patrizia Fiori

    2010-09-01

    Full Text Available Patrizia Fiori1, Antonio Monaco1, Maria Giannetti Luigi21Central Operative Unit of Neurology, 2Infantile Neuropsychiatry and Social Service, ASL AV, Civil Hospital of Ariano Irpino, University of Naples, ItalyAbstract: Body dysmorphic disorder is a body image dysperception, characterized either by an excessive preoccupation with a presumed or minimal flaw in appearance, or by unrecognition, denial, or even neglect regarding an obvious defect. These features are evaluated by a novel questionnaire, the Brief Assessment of Negative Dysmorphic Signs (BANDS. Moreover, the temperament and character background is examined. The relationship with addictive mentality/behavior and schizoaffectivity is also highlighted. Lastly, the potential shift toward cognitive impairment and dementia is considered.Keywords: body dysmorphic disorder, schizoaffectivity, addiction, behavioral-cognitive impairment

  19. The nuclear materials control technology briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Hartwell, J.K.; Fernandez, S.J.

    1992-03-01

    As national and international interests in nuclear arms control and non-proliferation of nuclear weapons, intensify, it becomes ever more important that contributors be aware of the technologies available for the measurement and control of the nuclear materials important to nuclear weapons development. This briefing book presents concise, nontechnical summaries of various special nuclear material (SNM) and tritium production monitoring technologies applicable to the control of nuclear materials and their production. Since the International Atomic Energy Agency (IAEA) operates a multinational, on-site-inspector-based safeguards program in support of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), many (but not all) of the technologies reported in this document are in routine use or under development for IAEA safeguards.

  20. STS-114: Discovery Launch Postponement Press Briefing

    Science.gov (United States)

    2005-01-01

    This press briefing addresses the problem that occurred prior to the launch of the STS-114. Dean Acosta, Deputy Assistant Administrator of Public Affairs, introduces the panel which consists of Dr. Michael Griffin, NASA Administrator, William Readdy, Associate Administrator for Space Operations, Wayne Hale, Space Shuttle Program Deputy Manager, Steve Poulas, Orbiter Project Manager, Mike Leinbach, NASA Launch Director, and Bill Parsons, Space Shuttle Program Manager. Wayne Hale expresses that a problem occurred with one of the low level sensors in the hydrogen tank and that the cause of the problem must be identified and rectified. Steve Poulos talks about establishing a troubleshooting plan as a part of the scrub effort and Mike Leinbach describes the process of draining the external tank. Wayne Hale answers questions about the sensors and if the Space Shuttle Discovery is safe to fly and Steve Poulos answers questions about the possible suspects for this problem.

  1. Bats and Viruses: a Brief Review

    Institute of Scientific and Technical Information of China (English)

    Lin-Fa Wang

    2009-01-01

    Bats, probably the most abundant, diverse and geographically dispersed vertebrates on earth, have recently been shown to be the reservoir hosts of a number of emerging viruses responsible for severe human and livestock disease outbreaks. Flying foxes have been demonstrated to be the natural reservoir for Hendra and Nipah viruses. Evidence supporting the possibility of bats as potential reservoirs for SARS coronavirus (SARS-CoV) and Ebola virus has also been reported. The recent discovery of these viruses and other viruses occurring naturally in the bat population provides a unique insight into a diverse pool of potentially emergent and pathogenic viruses. The factors which influence the ability of zoonotic viruses to effectively cross the species barrier from bats to other animal populations are poorly understood. A brief review is provided here on the recently emerged bat viruses and on current and future strategies for research in this area.

  2. Delusional disorders in dermatology: a brief review.

    Science.gov (United States)

    Robles, David T; Romm, Sharon; Combs, Heidi; Olson, Jonathan; Kirby, Phil

    2008-01-01

    There are several unique psychiatric disorders that are likely to present to a dermatologist because of their accompanying skin complaints. Delusions of parasitosis (DP) is a fixed, false belief of parasitic infestation that may lead patients to compulsively self-mutilate while attempting to remove the non-existent parasites. Morgellons disease is a controversial condition characterized by a fixed belief that fibers that are imbedded or extruding from the skin; this condition is likely in the spectrum of DP. Body dysmorphic disorder (BDD) is a preoccupation with an imagined defect in appearance that causes significant distress and is associated with time consuming rituals, isolation, depression, and increased risk of suicide. Olfactory reference syndrome (ORS) is a preoccupation with body odor leading to the stigmata of shame, embarrassment, and social isolation. This brief review examines each of these conditions and their management because any one of them may present to a dermatologist. PMID:18713583

  3. Brief fasting, stress, and cognition in children.

    Science.gov (United States)

    Pollitt, E; Leibel, R L; Greenfield, D

    1981-08-01

    Effects of skipping breakfast on speed and accuracy of response in a number of problem solving tasks were assessed in 9- to 11-yr-old, well-nourished children. The conceptual framework for this study was derived from an experimental model of the effects of mild environmental stress, e.g., noise, on human performance. Plasma glucose, beta-hydroxybutyrate, lactate, and free fatty acids were used as indicators of the induced metabolic stress, and the extent of their association with the behavioral measures was determined. Fasting had an adverse effect on the accuracy of responses in problem solving, but it had a beneficial effect on immediate recall in short-term memory. Both effects are explained by a heightened arousal level associated with the brief experimental fast. PMID:7270476

  4. Brief overview of geophysical probing technology

    International Nuclear Information System (INIS)

    An evaluation of high-resolution geophysical techniques which can be used to characterize a nulcear waste disposal site is being conducted by the Lawrence Livermore National Laboratory (LLNL) at the request of the US Nuclear Regulatory Commisson (NRC). LLNL is involved in research work aimed at evaluating the current capabilities and limitations of geophysical methods used for site selection. This report provides a brief overview of the capabilities and limitations associated with this technology and explains how our work addresses some of the present limitations. We are examining both seismic and electromagnetic techniques to obtain high-resolution information. We are also assessing the usefulness of geotomography in mapping fracture zones remotely. Finally, we are collecting core samples from a site in an effort to assess the capability of correlating such geophysical data with parameters of interest such as fracture continuity, orientation, and fracture density

  5. History of Hanford Site Defense Production (Brief)

    International Nuclear Information System (INIS)

    This paper acquaints the audience with the history of the Hanford Site, America's first full-scale defense plutonium production site. The paper includes the founding and basic operating history of the Hanford Site, including World War II construction and operations, three major postwar expansions (1947-55), the peak years of production (1956-63), production phase downs (1964-the present), a brief production spurt from 1984-86, the end of the Cold War, and the beginning of the waste cleanup mission. The paper also delineates historical waste practices and policies as they changed over the years at the Hanford Site, past efforts to chemically treat, ''fractionate,'' and/or immobilize Hanford's wastes, and resulting major waste legacies that remain today. This paper presents original, primary-source research into the waste history of the Hanford Site. Finally, the paper places the current Hanford Site waste remediation endeavors in the broad context of American and world history

  6. Brief description of the Wackersdorf Reprocessing Facility

    International Nuclear Information System (INIS)

    The DWK is now planning the construction and operation of a facility for the reprocessing of spent fuel elements and the fabrication of mixed-oxide fuel elements which will initially have an average daily throughput of 2 tons (t) of nuclear fuel. The application required by the Atomic Law was submitted to the Bavarian State Ministry for State Development and Environmental Matters on October 28, 1982. According to Par. 3, Section 1, No. 1 of the Atomic Law Procedural Ordinance such an application for permission in accordance with par. 7 AtL must explicitly be accompanied by a safety report which shall make it possible for third parties to make a judgment whether the impacts associated with the facility and its operation could damage their rights. The safety report is intended to present and explain the concept of the facility, the safety-technological design bases, and the operation of the plant, including its operation and safety systems and the impacts and proposed preventive measures. In addition to the detailed presentations in the safety report, Par. 3 of the Atomic Law Procedural Ordinance also requires a brief description of the plant designed for general public understanding, suitable for the design, which will also explain the expected impacts on the general environment and the surrounding area. Hence the brief description presents and explains the following matters: the site; the technology and state of the art for reprocessing of spent nuclear fuel; the structure and function of the proposed facility; safety provisions of the proposed facility and the management of perturbations in operation; the impacts of the facility and its operation on the environment; measures to be taken for dealing with the radioactive wastes; and provisions for ultimate shut-down of the facility

  7. Academic Spending versus Athletic Spending: Who Wins? Issue Brief

    Science.gov (United States)

    Desrochers, Donna M.

    2013-01-01

    Athletics are big business on many college campuses, but does this come with a price tag? This issue brief looks at academic and athletic spending in NCAA Division I public universities between 2005 and 2010. Among a host of findings, this brief shows that the athletic departments of most public colleges and universities competing in NCAA Division…

  8. Extra-Curricular Inequality. Research Brief. Edition 1

    Science.gov (United States)

    Sutton Trust, 2014

    2014-01-01

    This Research Briefing analyses Office for National Statistics data and finds children from the most advantaged households benefit from significantly more spending on extra-curricular activities and private tutoring than their poorer peers. The brief also includes the Trust's annual polling on private tuition and new polling on parents and…

  9. 5 CFR 185.136 - Post-hearing briefs.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Post-hearing briefs. 185.136 Section 185.136 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file...

  10. Fetal Alcohol Exposure Reduces Adult Brain Plasticity. Science Briefs

    Science.gov (United States)

    National Scientific Council on the Developing Child, 2007

    2007-01-01

    "Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This Brief summarizes the findings and implications of "Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice" (I. Y. Choi; A. M. Allan; and L. A. Cunningham). Observations of mice…

  11. Participation in VET in Schools. LSAY Briefing Number 15

    Science.gov (United States)

    Coates, Hamish; Rothman, Sheldon

    2008-01-01

    This "Briefing" looks at participation in VET in Schools programs by members of three groups of young people who have been part of Longitudinal Surveys of Australian Youth (LSAY) since 1995, when VET in Schools offerings experienced sustained growth. Highlights of this briefing include: (1) Student enrolments in VET in Schools have grown…

  12. Salt Lake 2002 world broadcaster briefing: December 1998

    OpenAIRE

    2014-01-01

    This briefing contains activities of SLOC as of December 1998. SLOC has developed a comprehensive budget for the 2002 Olympic Winter Games that is presented in this briefing. SLOC’s goals are to minimize costs while maximizing the potential for success, to establish a baseline for action and control, and to allow for continued planning and definition of the scope of the Games.

  13. Briefing note. Severity of the December 2015 floods - preliminary analysis

    OpenAIRE

    Barker, Lucy; Hannaford, Jamie; Parry, Simon

    2016-01-01

    The purpose of this briefing note is to collate some of the key points from the December 2015 Hydrological Summary, and to provide some additional context beyond the space and format constraints of the Summary. Neither the Hydrological Summary nor the briefing note provide a fully comprehensive review of the severity of the December 2015 floods.

  14. 14 CFR 121.571 - Briefing passengers before takeoff.

    Science.gov (United States)

    2010-01-01

    ... citations affecting § 121.571, see the List of CFR Sections Affected, which appears in the Finding Aids... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Briefing passengers before takeoff. 121.571... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Operations § 121.571 Briefing...

  15. Talent Wars: The International Market for Academic Staff. Policy Briefing

    Science.gov (United States)

    Universities UK, 2007

    2007-01-01

    This policy briefing aims to raise awareness and understanding among policy-makers and UK higher institutions of the international dimensions of academic staff recruitment and the factors that may influence it. This briefing summarises recent research and considers its implications for institutions and for national policies. Annex A contains:…

  16. Case Book of Brief Psychotherapy with College Students.

    Science.gov (United States)

    Cooper, Stewart E., Ed.; Archer, James Jr., Ed.; Whitaker, Leighton C., Ed.

    This book examines brief therapy in a developmental context with young adults whose clinical problems often relate to or are caused by significant developmental impasses. The purpose in presenting this book is to provide case studies to illustrate a variety of brief therapy approaches with young adults who are college students between the ages of…

  17. First-Session Competency: The Brief Strategic Therapy Scale-1

    Science.gov (United States)

    Amini, Rachelle L.; Woolley, Scott R.

    2011-01-01

    The first session in brief strategic therapy is the most critical phase of treatment. More than a mere "assessment phase," the first session in a true intervention sets the stage for all subsequent therapeutic maneuvers. This article presents a supervisory observation tool, the Brief Strategic Therapy Scale-1 (BSTS-1), a fidelity measure proposed…

  18. "Talking Pictures Therapy" as Brief Therapy in a School Setting

    Science.gov (United States)

    Loewenthal, Del

    2013-01-01

    This article presents "talking pictures therapy" as an approach to brief therapy, in which photographs are used in brief psychotherapy and counseling with the purpose of enabling clients to express and explore through photographs aspects of their lives they would like to talk about. The author presents case examples using "talking pictures…

  19. Screening and Brief Interventions: Research Update. Prevention Update

    Science.gov (United States)

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

    2012-01-01

    Developed in 1993 at the University of Washington, Brief Alcohol Screening and Intervention for College Students (BASICS) is a preventive intervention program to reduce drinking and enhance awareness about alcohol-related issues. BASICS targets college students who are considered at risk because of heavy drinking behaviors. The brief intervention…

  20. NASA Tech Briefs, May 1999. Volume 23, No. 5

    Science.gov (United States)

    1999-01-01

    Topics include: special coverage sections on sensors and composites and plastics, and sections on electronic components and systems, software, materials, mechanics, machinery and automation, bio-medical, physical sciences, book and reports, and a special section of Photonics Tech Briefs and Rapid Product Development Tech Briefs.

  1. NASA Tech Briefs, October 1999. Volume 23, No. 10

    Science.gov (United States)

    1999-01-01

    Topics include: special coverage section on data acquisition and sensors and sections on electronic components and systems, software, materials, mechanics, machinery/automation, manufacturing/fabrication, bio-medical, physical sciences, information sciences, book and reports, and special section of Electronics Tech Briefs and Motion Control Tech briefs

  2. Use of Brief Intelligence Tests in the Identification of Giftedness

    Science.gov (United States)

    Pierson, Eric E.; Kilmer, Lydia M.; Rothlisberg, Barbara A.; McIntosh, David E.

    2012-01-01

    Schools often administer brief intelligence tests as the first step in the identification of students who are cognitively gifted. However, brief measures are often used without consideration of underlying constructs or the psychometric properties of the measures and without regard to the links between screening decisions and educational…

  3. Drama in design: An open brief to design for wellbeing

    NARCIS (Netherlands)

    Liao, T.; Person, F.E.O.K.

    2012-01-01

    This paper presents a design module in which student teams were challenged in an open brief to design for wellbeing. To design for wellbeing is difficult. Wellbeing is ambiguous, hard to define and highly personal. In the process of defining their own briefs, a drama workshop was set up to help the

  4. Examining the Efficacy of a Brief Mindfulness-Based Stress Reduction (Brief MBSR) Program on Psychological Health

    Science.gov (United States)

    Bergen-Cico, Dessa; Possemato, Kyle; Cheon, Sanghyeon

    2013-01-01

    Objective: The purpose of the study was to examine potential psychological health benefits of participating in a brief (5-week) mindfulness-based stress reduction (brief MBSR) program integrated into an academic course. Participants: Participants were 119 undergraduate students (treatment: "n" = 72; control: "n" = 47) enrolled…

  5. Briefing highlights space weather risks to GPS

    Science.gov (United States)

    Tretkoff, Ernie

    2011-07-01

    Solar storms, which are expected to increase as the Sun nears the most active phase of the solar cycle, can disrupt a variety of technologies on which society relies. Speakers at a 22 June briefing on Capitol Hill in Washington, D. C., focused on how space weather can affect the Global Positioning System (GPS), which is used in a wide range of industries, including commercial air travel, agriculture, national security, and emergency response. Rocky Stone, chief technical pilot for United Airlines, noted that GPS allows more aircraft to be in airspace, saves fuel, and helps aircraft move safely on runways. “Improvements in space weather forecasting need to be pursued,” he said. Precision GPS has also “changed the whole nature of farming,” said Ron Hatch, Director of Navigation Systems, NavCom Technology/John Deere. GPS makes it possible for tractors to be driven in the most efficient paths and for fertilizer and water to be applied precisely to the areas that most need them. Space weather-induced degradation of GPS signals can cause significant loss to farms that rely on GPS. Elizabeth Zimmerman, Deputy Associate Administrator for the Office of Response and Recovery at the Federal Emergency Management Agency (FEMA), described how FEMA relies on GPS for disaster recovery. The agency is developing an operations plan for dealing with space weather, she said.

  6. Market Brief : Turkey oil and gas pipelines

    International Nuclear Information System (INIS)

    This report presented some quick facts about oil and gas pipelines in Turkey and presented opportunities for trade. The key players and customers in the oil and gas sector were described along with an export check list. Turkey is looking into becoming an energy bridge between oil and gas producing countries in the Middle East, Central Asia and Europe. The oil and gas sectors are dominated by the Turkish Petroleum Corporation, a public enterprise dealing with exploration and production, and the State Pipeline Corporation which deals with energy transmission. They are also the key buyers of oil and gas equipment in Turkey. There are several pipelines connecting countries bordering the Caspian Sea. Opportunities exist in the areas of engineering consulting as well as contracting services for oil and gas pipeline transmission and distribution. Other opportunities lie in the area of pipeline construction, rehabilitation, materials, equipment, installation, and supervisory control and data acquisition (SCADA) systems. Currently, the major players are suppliers from Italy, Germany, France, United States and Japan. Turkey has no trade barriers and imported equipment and materials are not subjected to any restriction. The oil and gas market in Turkey expected in increase by an average annual growth rate of 15 per cent from 2001 to 2003. A brief description of pipeline projects in Turkey was presented in this report along with a list of key contacts and support services. 25 refs., 1 append

  7. A Brief History of Black Holes

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2006-04-01

    Full Text Available Neither the layman nor the specialist, in general, have any knowledge of the historical circumstances underlying the genesis of the idea of the Black Hole. Essentially, almost all and sundry simply take for granted the unsubstantiated allegations of some ostentatious minority of the relativists. Unfortunately, that minority has been rather careless with the truth and is quite averse to having its claims corrected, notwithstanding the documentary evidence on the historical record. Furthermore, not a few of that vainglorious and disingenuous coterie, particularly amongst those of some notoriety, attempt to dismiss the testimony of the literature with contempt, and even deliberate falsehoods, claiming that history is of no importance. The historical record clearly demonstrates that the Black Hole has been conjured up by combination of confusion, superstition and ineptitude, and is sustained by widespread suppression of facts, both physical and theoretical. The following essay provides a brief but accurate account of events, verifiable by reference to the original papers, by which the scandalous manipulation of both scientific and public opinion is revealed

  8. Market brief : natural gas in Turkey

    International Nuclear Information System (INIS)

    Turkey may soon become an important transit route to Europe for natural gas imported from the Caucasus, Iran, and other Middle Eastern countries. This market brief provided an overview of Turkey's natural gas market and industry, and examined investment and business opportunities for Canadian businesses. Consumption of natural gas in Turkey has grown by 14.8 per cent annually in the last decade. Transmission equipment expenditures total approximately $400 million annually. It is expected that the demand for environmental and engineering services for natural gas-related industries will grow by 15 per cent annually over the next decade. There are currently several opportunities for Canadian suppliers of equipment, engineering, and construction services. Turkey's expected full European Union (EU) membership will require Turkey to adopt EU environmental and emissions standards. Potential investors in Turkey require operating licences from Turkey's Energy Market Regulatory Authority (EMRA). All state procurement is by tender, while BOTAS, the state-owned gas company dominates both imports and the transmission of gas. Market entry considerations were also presented. 7 refs., 4 tabs., 2 figs

  9. Hubble Space Telescope Briefing: HST Science Overview

    Science.gov (United States)

    1994-01-01

    This NASA Kennedy Space Center video release presents a broad overview of the science that is now possible as a result of the servicing of the Hubble Space Telescope (HST). Dr. Ed Weiler (HST Program Scientist, NASA Headquarters), Dr. Dave Leckrone (HST, Senior Project Scientist, Goddard Space Flight Center (GSFC)), Dr. John Trauger (Wide Field Planetary Camera 2 (WFPC2) Principal Investigator, Jet Propulsion Lab. (JPL)), Dr. Chris Burrows (WFPC2 Co-Investigator, Space Telescope Science Inst.(STSci)-European Space Agency (ESA), Jim Crocker ((Corrective Optics Space Telescope Axial Replacement) COSTAR Team Leader, STSci), Dr. Holland Ford (COSTAR Project Scientist, Johns Hopkins Univ., STSci), and Dr. Duccio Machetto (European Space Agency (ESA)) give brief presentations, which feature images of stars and galaxies taken from the ground, from WFPC1 (prior to the servicing mission), and from WFPC2 (after the servicing mission). The main theme of the discussions center around the spherical aberration that was found in the images prior to servicing and the corrected images seen without the aberration following servicing. A question and answer period rounds out the press conference, with questions posed from scientific journalists at GSFC and other NASA centers.

  10. A brief history of mathematics in finance

    Directory of Open Access Journals (Sweden)

    Erdinç Akyıldırım

    2014-03-01

    Full Text Available In the list of possible scapegoats for the recent financial crises, mathematics, in particular mathematical finance has been ranked, without a doubt, as the first among many and quants, as mathematicians are known in the industry, have been blamed for developing and using esoteric models which are believed to have caused the deepening of the financial crisis. However, as Lo and Mueller (2010 state “Blaming quantitative models for the crisis seems particularly perverse, and akin to blaming arithmetic and the real number system for accounting fraud.” Throughout the history, mathematics and finance have always been in a close relationship. Starting from Babylonians, through Thales, and then Fibonacci, Pascal, Fermat, Bernoulli, Bachelier, Wiener, Kolmogorov, Ito, Markowitz, Black, Scholes, Merton and many others made huge contributions to the development of mathematics while trying to solve finance problems. In this paper, we present a brief historical perspective on how the development of finance theory has influenced and in turn been influenced by the development of mathematical finance theory.

  11. Legal briefing: organ donation and allocation.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to organ donation and allocation. This topic has been the subject of recent articles in JCE. Organ donation and allocation have also recently been the subjects of significant public policy attention. In the past several months, legislatures and regulatory agencies across the United States and across the world have changed, or considered changing, the methods for procuring and distributing human organs for transplantation. Currently, in the U.S., more than 100,000 persons are waiting for organ transplantation. In China, more than 1.5 million people are waiting. Given the chronic shortage of available organs (especially kidneys and livers) relative to demand, the primary focus of most legal developments has been on increasing the rate of donation. These and related developments are usefully divided into the following 12 topical categories: 1. Revised Uniform Anatomical Gift Act. 2. Presumed Consent and Opt-Out. 3. Mandated Choice. 4. Donation after Cardiac Death. 5. Payment and Compensation. 6. Donation by Prisoners. 7. Donor Registries. 8. Public Education. 9. Other Procurement Initiatives. 10. Lawsuits and Liability. 11. Trafficking and Tourism. 12. Allocation and Distribution. PMID:21089996

  12. NASA Tech Briefs, December 1988. Volume 12, No. 11

    Science.gov (United States)

    1988-01-01

    This month's technical section includes forecasts for 1989 and beyond by NASA experts in the following fields: Integrated Circuits; Communications; Computational Fluid Dynamics; Ceramics; Image Processing; Sensors; Dynamic Power; Superconductivity; Artificial Intelligence; and Flow Cytometry. The quotes provide a brief overview of emerging trends, and describe inventions and innovations being developed by NASA, other government agencies, and private industry that could make a significant impact in coming years. A second bonus feature in this month's issue is the expanded subject index that begins on page 98. The index contains cross-referenced listings for all technical briefs appearing in NASA Tech Briefs during 1988.

  13. Sustainable Markets Investment Briefings: the regulatory taking doctrine

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the third of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 3 introduces one of the most controversial legal doctrines of investment law – 'regulatory taking' – and sets out its implications for sustainable development.

  14. A brief examination of optical tagging technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Mark R.; Cahill, Paul A. (Aspecular Optics, Dayton, OH); Drummond, Timothy J.; Wilcoxon, Jess Patrick

    2003-07-01

    Presented within this report are the results of a brief examination of optical tagging technologies funded by the Laboratory Directed Research and Development (LDRD) program at Sandia National Laboratories. The work was performed during the summer months of 2002 with total funding of $65k. The intent of the project was to briefly examine a broad range of approaches to optical tagging concentrating on the wavelength range between ultraviolet (UV) and the short wavelength infrared (SWIR, {lambda} < 2{micro}m). Tagging approaches considered include such things as simple combinations of reflective and absorptive materials closely spaced in wavelength to give a high contrast over a short range of wavelengths, rare-earth oxides in transparent binders to produce a narrow absorption line hyperspectral tag, and fluorescing materials such as phosphors, dies and chemically precipitated particles. One technical approach examined in slightly greater detail was the use of fluorescing nano particles of metals and semiconductor materials. The idea was to embed such nano particles in an oily film or transparent paint binder. When pumped with a SWIR laser such as that produced by laser diodes at {lambda}=1.54{micro}m, the particles would fluoresce at slightly longer wavelengths, thereby giving a unique signal. While it is believed that optical tags are important for military, intelligence and even law enforcement applications, as a business area, tags do not appear to represent a high on return investment. Other government agencies frequently shop for existing or mature tag technologies but rarely are interested enough to pay for development of an untried technical approach. It was hoped that through a relatively small investment of laboratory R&D funds, enough technologies could be identified that a potential customers requirements could be met with a minimum of additional development work. Only time will tell if this proves to be correct.

  15. Legal briefing: conscience clauses and conscientious refusal.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to conscience clauses and conscientious refusal. Not only has this topic been the subject of recent articles in this journal, but it has also been the subject of numerous public and professional discussions. Over the past several months, conscientious refusal disputes have had an unusually high profile not only in courthouses, but also in legislative and regulatory halls across the United States. Healthcare providers' own moral beliefs have been obstructing and are expected to increasingly obstruct patients' access to medical services. For example, some providers, on ethical or moral grounds, have denied: (1) sterilization procedures to pregnant patients, (2) pain medications in end-of-life situations, and (3) information about emergency contraception to rape victims. On the other hand, many healthcare providers have been forced to provide medical treatment that is inconsistent with their moral beliefs. There are two fundamental types of conscientious objection laws. First, there are laws that permit healthcare workers to refuse providing - on ethical, moral, or religious grounds healthcare services that they might otherwise have a legal or employer-mandated obligation to provide. Second, there are laws directed at forcing healthcare workers to provide services to which they might have ethical, moral, or religious objections. Both types of laws are rarely comprehensive, but instead target: (1) certain types of healthcare providers, (2) specific categories of healthcare services, (3) specific patient circumstances, and (4) certain conditions under which a right or obligation is triggered. For the sake of clarity, I have grouped recent legal developments concerning conscientious refusal into eight categories: 1. Abortion: right to refuse 2. Abortion: duty to provide 3. Contraception: right to refuse 4. Contraception: duty to provide 5. Sterilization: right to refuse 6. Fertility, HIV, vaccines

  16. Non-destructive foraminiferal paleoclimatic proxies: A brief insight

    Digital Repository Service at National Institute of Oceanography (India)

    Saraswat, R.

    Non-Destructive Foraminiferal Paleoclimatic Proxies: A Brief Insight The knowledge of past climate can help us to understand imminent climatic changes. Oceans are the vast archives of past climate. Various indirect techniques termed as proxies...

  17. Posterior tibial tendon rupture—a brief report

    OpenAIRE

    Wootton, J. R.

    1990-01-01

    This brief report highlights the rarity of a posterior tibial tendon rupture, the problem of a progressive painful pes planus if the diagnosis is missed, and full return to sporting activities if treated early by surgical repair.

  18. Usability Briefing - a process model for healthcare facilities

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    2014-01-01

    Background: In complex buildings with many types of users it can be difficult to satisfy the numerous, often contradictory requirements. Research in usability mostly focuses on evaluating products or facilities with users, after they were built. This paper is part of a PhD project “Usability...... purpose is to develop a process model for applying it on complex building projects. Usability briefing is a process in which users are actively involved, not only in evaluations and data gathering, but also in a continuous briefing process with focus on usability. Approach: The model is inductively...... briefing, combining the four interrelated activities of 1) briefing, 2) user involvement, 3) evaluations and 4) design. The model provides a visual overview of the four activities in all the building design phases. The approach combines continuous user presence, cocreation, design and evaluation with...

  19. Issue briefs on low-level radioactive wastes

    International Nuclear Information System (INIS)

    This report contains 4 Issue Briefs on low-level radioactive wastes. They are entitled: Handling, Packaging, and Transportation, Economics of LLW Management, Public Participation and Siting, and Low Level Waste Management

  20. Could Inducing Brief, Mild 'Fever' Help Ease Depression?

    Science.gov (United States)

    ... html Could Inducing Brief, Mild 'Fever' Help Ease Depression? Small study suggests heating the body might alter ... brain region is less active in people with depression, the researchers explained. "Our hope is to find ...

  1. NASA Tech Briefs, January 1999. Volume 23, Mp/ 1

    Science.gov (United States)

    1999-01-01

    Topics include: special coverage sections on sensors and data acquisition and sections on electronic components and circuits, electronic software, materials, mechanics, bio-medical physical sciences, book and reports, and a special section of Photonics Tech Briefs.

  2. NASA Tech Briefs, November 2002. Volume 26, No. 11

    Science.gov (United States)

    2002-01-01

    Topics include: a technology focus on engineering materials, electronic components and systems, software, mechanics, machinery/automation, manufacturing, bio-medical, physical sciences, information sciences book and reports, and a special section of Photonics Tech Briefs.

  3. NASA Tech Briefs, September 2001. Volume 25, No. 9

    Science.gov (United States)

    2001-01-01

    Topics include: special coverage section on sensors, and sections on electronic components systems, software, materials, machinery/automation, manufacturing/fabrication, bio-medical, book and reports, and a special section of Photonics Tech Briefs.

  4. NASA Tech Briefs, July 2002. Volume 26, No. 7

    Science.gov (United States)

    2002-01-01

    Topics include: a technology focus sensors, software, electronic components and systems, materials, mechanics, machinery/automation, manufacturing, bio-medical, physical sciences, information sciences, book and reports, and a special section of Photonics Tech Briefs.

  5. NASA Tech Briefs, September 2002. Volume 26, No. 9

    Science.gov (United States)

    2002-01-01

    Topics include: a technology focus on data acquisition, electronic components and systems, software, materials, mechanics, machinery/automation, bio-medical, physical sciences, book and reports, and a special section of Photonics Tech Briefs.

  6. The 30-Year Anniversary of Pediatric Neurology Briefs

    OpenAIRE

    John J Millichap; J Gordon Millichap

    2016-01-01

    Over the past 30 years, Pediatric Neurology Briefs (PNB) has been published monthly as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology.

  7. Center for Information Systems Research Research Briefings 2002

    OpenAIRE

    Ross, Jeanne W.

    2003-01-01

    This paper is comprised of research briefings from the MIT Sloan School of Management's Center for Information Systems Research (CISR). CISR's mission is to perform practical empirical research on how firms generate business value from IT.

  8. FREE Policy Brief No. 3 - Women's Football and Female Fans

    OpenAIRE

    Pfister, Gertrud Ursula; Sonntag, Albrecht; Ranc, David

    2015-01-01

    Football Research in an Enlarged Europe (FREE).This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football.

  9. PROGRESSES IN IONOSPHERIC RESEARCH, 2000-2002: A BRIEF REVIEW

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This brief report reviews the recent developments in ionospheric physics studies made by Chinese scientists. It covers areas from the numerical simulations and theoretical researches on ionospheric properties, ionospheric disturbances, space weather events in the ionosphere to ionospheric obserwtions.

  10. Brief Guide to Genomics: DNA, Genes and Genomes

    Science.gov (United States)

    ... de genómica A Brief Guide to Genomics DNA, Genes and Genomes Deoxyribonucleic acid (DNA) is the chemical ... needed to build the entire human body. A gene traditionally refers to the unit of DNA that ...

  11. Brief Integrative Multiple Behavior Intervention Effects and Mediators for Adolescents

    OpenAIRE

    Werch, Chudley E. (Chad); Bian, Hui; Carlson, Joan; Moore, Michele J.; DiClemente, Carlo C.; Huang, I-Chan; Ames, Steven C.; Thombs, Dennis; Robert M Weiler; Pokorny, Steven B.

    2010-01-01

    This study evaluated the efficacy of a brief integrative multiple behavior intervention and assessed risk factors as mediators of behavioral outcomes among older adolescents. A randomized controlled trial was conducted with participants randomly assigned to either a brief intervention or standard care control with 3-month follow-up. A total of 479 students attending two public high schools participated. Participants receiving the intervention showed a significant reduction in quantity x frequ...

  12. FREE Policy Brief No. 3 - Women's Football and Female Fans

    DEFF Research Database (Denmark)

    Pfister, Gertrud Ursula; Sonntag, Albrecht; Ranc, David

    2015-01-01

    Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football.......Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football....

  13. A Validation Study of the Brief Alcohol Use Disorder Identification Test (AUDIT): A Brief Screening Tool Derived from the AUDIT

    OpenAIRE

    So, Kyungseop; Sung, Eunju

    2013-01-01

    Background The prevalence of alcohol use disorder (AUD) is very high in Korea. To identify AUD in the busy practice setting, brevity of screening tools is very important. We derived the brief Alcohol Use Disorders Identification Test (AUDIT) and evaluated its performance as a brief screening test. Methods One hundred male drinkers from Kangbuk Samsung Hospital primary care outpatient clinic and psychiatric ward for alcoholism treatment completed questionnaires including the AUDIT, cut down, a...

  14. Global Green New Deal. Policy Brief

    International Nuclear Information System (INIS)

    The 'Global Green New Deal' (GGND) presented here has three broad objectives. It should make a major contribution to reviving the world economy, saving and creating jobs, and protecting vulnerable groups. It should promote sustainable and inclusive growth and the achievement of the MDGs, especially ending extreme poverty by 2015. Also, it must reduce carbon dependency and ecosystem degradation. These are key risks along a path to a sustainable world economy. Our consultations and our commissioned research, summarized here in this Policy Brief, make a strong case for the active 'greening' of proposed fiscal stimulus packages. However, this must also be backed by necessary changes in international and domestic policy architectures, as the current framework is biased in favour of resurrecting an unsustainable 'brown economy'. Our proposals are therefore grouped under three categories - targeted stimulus spending in 2009-10, changes in domestic policies, and changes in international policy architecture. Furthermore, we recognize that many less developed countries do not have the resources of their own and will have to rely on foreign aid and support, both financial and non-financial. We propose that the fiscal stimulus (to be applied over 2009 and 2010) should prioritize energy efficient buildings and investments in sustainable transport and renewable energy. Developing countries should prioritize investment in agricultural productivity measures, freshwater management, and sanitation, as these have demonstrable and exceptional social returns. Domestic policy reforms are recommended to substantially reduce perverse subsidies (eg: fossil fuels) and instead to create positive incentives and appropriate taxes which will encourage a greener economy. Domestic reforms should also address some common issues in land use and urban policy. Integrated management of freshwater would also require some domestic policy changes, and this should be prioritized by developing countries

  15. Zora’s Politics: A Brief Introduction

    Directory of Open Access Journals (Sweden)

    Ernest Julius Mitchell II

    2013-09-01

    Full Text Available In his introduction to reading Zora Neale Hurston’s politics, Mitchell argues that contemporary scholarship has misread Hurston in significant ways, distorting Hurston’s work and reputation to serve contesting political agendas; thus, in recent years, she has been associated with “a bewildering array of affiliations: republican, libertarian, radical democrat, reactionary conservative, black cultural nationalist, anti-authoritarian feminist, and woman-hating protofascist.” Recuperating Hurston from this impossible political melee of labels, Mitchell argues, requires a careful reading of Hurston’s work dating from her earliest pieces in the late 1920s, as well as surveying her many yet to be published manuscripts and letters; it requires recognition of the transnational and comparative lens through which she reported on political maneuvers and military histories, as well as reading not only her strong criticisms but also her silences, ironic phrasings, and nuanced critiques in her writings on global colonial enterprises. Mitchell’s introduction to the two Hurston essays here reprinted, “I Saw Negro Votes Peddled” (1950 and “Why the Negro Won’t Buy Communism” (1951—courtesy of the American Legion Magazine—is set in the larger frame of his assertion that Hurston’s work should be read with a deep appreciation of her staunch anticolonialism. Tracing her political philosophy through her views of how race and religion are used to valorize an international culture of violence that serves imperialistic and colonial ends, Mitchell takes his reader on a tour of Hurston’s transnational commentary—from the US occupation of Haiti, to the Spanish and British on the Florida peninsula; from Communist Russia and China, to election practices in the US—to set the stage for our encounters with these rarely read Hurston essays. Reading Mitchell’s “Zora’s Politics: A Brief Introduction” provides a firm foundation for a more

  16. Engine Development Design Margins Briefing Charts

    Science.gov (United States)

    Bentz, Chuck

    2006-01-01

    New engines experience durability problems after entering service. The most prevalent and costly is the hot section, particularly the high-pressure turbine. The origin of durability problems can be traced back to: 1) the basic aero-mechanical design systems, assumptions, and design margins used by the engine designers, 2) the available materials systems, and 3) to a large extent, aggressive marketing in a highly competitive environment that pushes engine components beyond the demonstrated capability of the basic technology available for the hardware designs. Unfortunately the user must operate the engine in the service environment in order to learn the actual thrust loading and the time at max effort take-off conditions used in service are needed to determine the hot section life. Several hundred thousand hours of operational service will be required before the demonstrated reliability of a fleet of engines or the design deficiencies of the engine hot section parts can be determined. Also, it may take three to four engine shop visits for heavy maintenance on the gas path hardware to establish cost effective build standards. Spare parts drive the oerator's engine maintenance costs but spare parts also makes lots of money for the engine manufacturer during the service life of an engine. Unless competition prevails for follow-on engine buys, there is really no motivation for an OEM to spend internal money to improve parts durability and reduce earnings derived from a lucrative spare parts business. If the hot section life is below design goals or promised values, the OEM migh argue that the engine is being operated beyond its basic design intent. On the other hand, the airframer and the operator will continue to remind the OEM that his engine was selected based on a lot of promises to deliver spec thrust with little impact on engine service life if higher thrust is used intermittently. In the end, a standoff prevails and nothing gets fixed. This briefing will propose

  17. Brief Behavioral Sleep Intervention for Adolescents: An Effectiveness Study.

    Science.gov (United States)

    Paavonen, E Juulia; Huurre, Taina; Tilli, Maija; Kiviruusu, Olli; Partonen, Timo

    2016-01-01

    Sleep disturbances are common among adolescents, but there are no brief interventions to treat them. The objective of this study was to evaluate the effectiveness of a brief semistructured, individually delivered sleep intervention to ameliorate adolescents' sleeping difficulties and lengthen sleep duration. All students aged 16-18 years in a high school were screened for sleeping difficulties and 36 students with the highest sleep problem scores were invited to the intervention. Postintervention improvements were observed on self-reported and actiwatch-registered sleep duration, self-reported sleep quality and sleep latency, perceived stress and anxiety (all p values 0.05). A brief individual sleep intervention can be effective in lengthening sleep duration and improving subjective sleep quality and well-being among adolescents. PMID:26378797

  18. Une introduction à l'univers de Briefs

    OpenAIRE

    Le Thanh, Nhan

    2013-01-01

    Nous proposons dans cet article d'étudier une structure d'information élémentaire, appelée Brief, permettant d'annoter des observations de phénomènes dans un contexte spatiotemporel via les réseaux d'interconnexion. Une des particularités de ces Briefs est qu'ils peuvent être utilisés dans une observation effectuée par l'homme ou par la machine à travers les objets communicants Cette forme d'annotation permettra une mise en place des services de traitement automatiques ou manuels des annotati...

  19. Renewable energy. From marginal to mainstream. Policy Brief

    Energy Technology Data Exchange (ETDEWEB)

    Veum, K.C.; Uslu, A.; De Coninck, H.C. [ECN Policy Studies, Petten (Netherlands)

    2013-04-15

    This policy brief aims to instigate a debate on the broader enabling conditions required to move renewable energy from marginal shares in the European energy system to a mainstream role. It does so by posing seven key questions related to public movement, the political-industrial complex, resources and sustainability, grids and markets, finance, legal procedures and overall policy. These questions require short- to medium-term attention to keep a long-term renewable energy system within the realm of possibilities. This policy brief also provides ECN's initial reflections on how these key questions could be addressed, and indicates which relevant expertise it can bring to the table.

  20. Paroxetine in the treatment of recurrent brief depressive disorder

    Directory of Open Access Journals (Sweden)

    Sathya Prakash

    2013-01-01

    Full Text Available Recurrent brief depressive disorder is now a well-recognized type of depressive disorder. However, there is still no clear evidence base for its treatment. The efficacy of several drugs including antidepressants and mood stabilizers in this disorder has been controversial. Methodological limitations need to be considered when interpreting the results of studies on efficacy of drugs in this disorder. We report a case of recurrent brief depressive disorder that responded dramatically to paroxetine. However, there is a need for larger, methodologically sound, double-blind, placebo-controlled studies.

  1. Shoemaker-Levy Comet Impact with Jupiter Press Briefing

    Science.gov (United States)

    1994-01-01

    A press briefing about the impact of the G fragment of Comet Shoemaker-Levy on the planet Jupiter is presented. The briefing occurred on July 18, 1994 just hours after the impact. Still black and white pictures taken from the Hubble Space Telescope are presented. Eugene Shoemaker, co-discoverer of the Comet, and Heidi Hammel, Principal Investigator for the Hubble Imaging team at MIT present preliminary results of the study of images and answer questions about the impact and the results of the impact on Jupiter.

  2. A Brief Introduction of the History of Linguistics

    Institute of Scientific and Technical Information of China (English)

    王非男

    2015-01-01

    Linguistics is generally defined as the scientific study of language. When it comes to the history of linguistics, it must be related to the origin of human language. This paper will give a brief introduction of the history of linguistics in Ancient Times and in the Middle Ages.

  3. Safety Planning Intervention: A Brief Intervention to Mitigate Suicide Risk

    Science.gov (United States)

    Stanley, Barbara; Brown, Gregory K.

    2012-01-01

    The usual care for suicidal patients who are seen in the emergency department (ED) and other emergency settings is to assess level of risk and refer to the appropriate level of care. Brief psychosocial interventions such as those administered to promote lower alcohol intake or to reduce domestic violence in the ED are not typically employed for…

  4. Adolescents, Alcohol, and Substance Abuse: Reaching Teens through Brief Interventions.

    Science.gov (United States)

    Monti, Peter M., Ed.; Colby, Suzanne M., Ed.; O'Leary, Tracy A., Ed.

    This publication reviews a variety of empirically supported approaches to dealing with alcohol and drug problems in adolescents. Its focus is to provide motivationally based brief interventions that can be delivered in a variety of contexts address key developmental considerations and draw on the latest knowledge about the processes of addictive…

  5. Toys in Physics Lectures and Demonstrations--A Brief Review

    Science.gov (United States)

    Guemez, J.; Fiolhais, C.; Fiolhais, M.

    2009-01-01

    The use of toys in physics teaching is common. This brief review of the physics of toys intends to show that they are not only very useful in lectures and demonstrations in order to motivate students but also very interesting from a scientific point of view. However, since their physics is sometimes too cumbersome, the effect can be the opposite.…

  6. NASA's Bioreactor: Growing Cells in a Microgravity Environment. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing cells in a microgravity environment for grades 9-12. Students are provided with plans for building a classroom bioreactor that can then be used with the included activity on seed growth in a microgravity environment. Additional experimental ideas are also suggested along with a history and background on microgravity…

  7. THE LIMITATIONS OF BRIEF INTELLIGENCE TESTING WITH YOUNG CHILDREN.

    Science.gov (United States)

    ROSENBERG, LEON A.; STROUD, MICHAEL

    A STUDY EXAMINED THE VALIDITY OF TWO BRIEF INTELLIGENCE SCALES, THE PEABODY PICTURE VOCABULARY TEST (PPVT) AND THE COLUMBIA MENTAL MATURITY SCALE (CMMS), TO SEE IF THESE TESTS OVERESTIMATED THE INCIDENCE OF INTELLECTUAL RETARDATION AMONG POVERTY AREA CHILDREN. THESE TWO TESTS AND AN EXPERIMENTAL MEASURE OF INTELLIGENCE, THE JOHNS HOPKINS…

  8. A NASA Recipe for Protein Crystallography. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing protein crystals. Protein crystals can be very difficult to grow. This activity for grades 9-12 provides a simple recipe for growing protein crystals from Brazil nuts. Included are a history of protein crystals, a discussion of microgravity effects on growth, connections to academic standards, and lab sheets. (MVL)

  9. Keeping Young People in (Vocational) Education: What Works? Briefing Note

    Science.gov (United States)

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    Too many young people leave education (including vocational education) too soon. Yet early leavers are at greater risk of long-term unemployment, poverty and crime, and now cost the European economy 1.25% of GDP. This brief report looks at the reasons why young people leave and what could be done to end this trend. Considerations for policy-makers…

  10. Brief-Term Psychological Adjustment of Sexually Abused Children.

    Science.gov (United States)

    Wagner, William G.

    1991-01-01

    In this study of brief-term concomitant of child sexual abuse, children's reports of self-concept and depression, and parents' ratings of their children's depressive symptomology, were examined for child victims of molestation or sexual abuse outside the family, and for nonabused children whose parents sought psychological services for them. (BB)

  11. Advancing Prediction of Foster Placement Disruption Using Brief Behavioral Screening

    Science.gov (United States)

    Hurlburt, Michael S.; Chamberlain, Patricia; DeGarmo, David; Zhang, Jinjin; Price, Joe M.

    2010-01-01

    Objective: Behavioral difficulties increase the risk that children will experience negative placement disruptions while in foster care. Chamberlain et al. (2006) found that the Parent Daily Report (PDR), a brief measure of parent-reported child behaviors, was a strong predictor of negative placement changes over 1 year among children receiving…

  12. A brief history of the Nuclear Physics Board

    International Nuclear Information System (INIS)

    This year the Nuclear Physics Board of the Science and Engineering Research Council ceases to exist. To mark its passing, a brief retrospective is presented of the organization that for nearly 30 years has supported fundamental research into the nature of matter, in the United Kingdom. (author)

  13. A brief review of biomedical sensors and robotics sensors

    OpenAIRE

    Yanli Luo; , Qiaoying Zhou; Wenbin Luo

    2016-01-01

    In this paper, we present a brief review of biomedical sensors and robotics sensors. More specifically, we will review the cochlear sensors and retinal sensors in the category of biomedical sensors and ultrasonic Sensors and infrared motion detection sensors in the category of robotic sensors. Our goal is to familiarize readers with the common sensors used in the fields of both biom

  14. Leadership: Improving Its Effectiveness. Research Action Brief Number 1.

    Science.gov (United States)

    ERIC Clearinghouse on Educational Management, Eugene, OR.

    This brief summarizes the major findings of significant research studies dealing with different leadership behaviors and strategies for increasing leadership effectiveness. Fred Fiedler's Contingency Theory of Leadership Effectiveness emphasizes that a leader's effectiveness is determined by how well his leadership style fits the specific…

  15. Perception of time under conditions of brief weightlessness

    Science.gov (United States)

    Lebedev, V. I.; Chekidra, I. F.; Kolosov, I. A.

    1975-01-01

    Results of experiments under conditions of brief weightlessness confirmed the theoretical concepts of the dependence of time perception on the emotional state of a man. The time test, together with other methods, can be used to precisely define the emotional state of subjects in stress situations.

  16. Implementing No Child Left Behind in Three States. Research Brief

    Science.gov (United States)

    Stecher, Brian M.; Epstein, Scott; Hamilton, Laura S.; Marsh, Julie A.; Robyn, Abby; McCombs, Jennifer Sloan; Russell, Jennifer; Naftel, Scott

    2008-01-01

    This research brief describes work done for RAND Education and documented in "Pain and Gain: Implementing No Child Left Behind in Three States, 2004-2006", Brian M. Stecher, Scott Epstein, Laura S. Hamilton, Julie A. Marsh, Abby Robyn, Jennifer Sloan McCombs, Jennifer Russell, and Scott Naftel." The three states discussed are: California, Georgia,…

  17. Continuous Briefing and User Participation in Building Projects

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2006-01-01

    building is required. A building project is often part of a change process of the organisation that is going to occupy the building, and this change process should be management carefully to reach a successful result. An important aspect of briefing is to manage the par-ticipation of the coming users in...

  18. Readiness for Change. Scaling-Up Brief. Number 3

    Science.gov (United States)

    Fixsen, Dean L.; Blase, Karen A.; Horner, Rob; Sugai, George

    2009-01-01

    The purpose of this "Brief" is to define the variables a state or large district leadership team may wish to consider as they determine if they are "ready" to invest in the scaling-up of an innovation in education. As defined here, "scaling up" means that at least 60% of the students who could benefit from an innovation have access to that…

  19. International Briefing 28: Training and Development in Quebec

    Science.gov (United States)

    Foucher, Roland; Hassi, Abderrahman

    2013-01-01

    This briefing examines training and development (T&D) in Quebec, one of 10 provinces and three territories that make up Canada. Quebec has three distinguishing characteristics that encourage analysis of its T&D separately from that of Canada as a whole. First, it is the only North American region with a majority francophone population. Second,…

  20. Support for Children Who Are Educated at Home. Research Briefing

    Science.gov (United States)

    Atkinson, Mary; Martin, Kerry; Downing, Dick; Harland, Jennie; Kendall, Sally; White, Richard

    2007-01-01

    With many thousands of home-educated children across the UK, the subject of support for the home-education community is widely debated. A report conducted by the NFER for the Esmee Fairbairn Foundation is based on detailed interviews with 20 home educators and presents findings on support needs. This Research Briefing illustrates some key findings…

  1. National Indian Education Association (NIEA) 2012 Legislative Agenda. Advocacy Briefing

    Science.gov (United States)

    National Indian Education Association, 2012

    2012-01-01

    This volume contains advocacy briefing papers presented at the 15th Annual National Indian Education Association (NIEA) Legislative Summit held February 15-15, 2012 in Washington, DC. The following papers are included: (1) Become a Powerful Advocate; (2) NIEA Legislative Priority for 2012: Reauthorization of the Elementary and Secondary Education…

  2. Counselor Interventions Preceding Client Laughter in Brief Therapy.

    Science.gov (United States)

    Falk, Dana R.; Hill, Clara E.

    1992-01-01

    Examined whether 6 categories of counselor humor and 4 categories of risk interventions preceded client laughter in 236 events from 8 cases of brief psychotherapy. Found most client laughter was mild and moderate, with only eight instances of strong laughter. Humorous interventions led to more client laughter than did interventions that encouraged…

  3. Effects of Therapist Response Modes in Brief Psychotherapy.

    Science.gov (United States)

    Hill, Clara E.; And Others

    1988-01-01

    Examined therapist response modes in 127 sessions of eight cases of brief psychotherapy with experienced therapists and anxious-depressed clients. Response modes had significant effect on immediate outcome, with self-disclosure, interpretation, approval, and paraphrase being the most helpful response modes. Found large individual differences in…

  4. Looking into a Deaf Child's Future: A Brief Treatment Approach.

    Science.gov (United States)

    Harvey, Michael A.; Green, Christine L.

    1990-01-01

    A hearing mother who reported obsessional thoughts about her deaf child's future underwent brief psychotherapy. Clinical hypnosis modified the mother's negative images of her child's future, and meetings attended by the mother, a vocational counselor, and deaf adults affirmed the more positive images. Theoretical descriptions and personal…

  5. NCLR Agenda for Hispanic Families: A Public Policy Briefing Book.

    Science.gov (United States)

    National Council of La Raza, Washington, DC.

    This briefing book offers guidance to Congress, the Administration, and state legislatures about which issues are important to the nation's largest ethnic groups, focusing on: "Civil Rights" (hate crimes, racial profiling, sentencing reform, and voting rights); "Economic Mobility" (e.g., banking and financial services, pensions, savings, Social…

  6. Information Brief on Green Power Marketing, 2nd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Sweezey, B.; Houston, A.

    1998-02-01

    This document is the second in a series of information briefs on green power marketing activity in the United States. It includes descriptions of utility green pricing programs, green power marketing activity, retail access legislation and pilot programs, and other data and information supporting the development of green power markets.

  7. Language of Instruction: Choices and Consequences. PREL Briefing Paper.

    Science.gov (United States)

    Simanu-Klutz, Fata

    This briefing paper focuses on the choices of instructional language in Pacific classrooms, as mandated by national or state policies, and discusses consequences of such choices on students' academic achievement and career preparation in the changing Pacific region. The paper first notes that in most South Pacific secondary schools, English is the…

  8. Response to Intervention and English Learners. CREATE Brief

    Science.gov (United States)

    Echevarria, Jana; Hasbrouck, Jan

    2009-01-01

    Response to Intervention (RTI) has emerged as a method for providing early academic assistance to students with difficulty learning. This brief outlines the tiered structure of RTI and how it can be implemented as an effective technique for teaching English learners who are having difficulty making academic progress. It touches on methods of…

  9. Regenerative medicine. Opportunities and challenges: a brief overview

    OpenAIRE

    Polak, Dame Julia

    2010-01-01

    Regenerative medicine is a new multi-disciplinary field aiming at the repair or replacement of disease body parts. The field is progressing at an unprecedented pace and although the opportunities are immense, many hurdles lie ahead. This brief review analyses the opportunities and challenges faced by regenerative medicine.

  10. Single-Session Brief Counseling in a High School.

    Science.gov (United States)

    Littrell, John M.; And Others

    1995-01-01

    Investigated three approaches to brief counseling: problem-focused with task, problem-focused without task, and solution-focused with task. Results suggested high school students made significant changes from the second-week follow-up to the sixth-week follow-up in alleviating their concerns and increasing the percentage of goal achieved. (RJM)

  11. NASA Tech Briefs, December 1995. Volume 19, No. 12

    Science.gov (United States)

    1995-01-01

    Topics include: a special focus section on Bio/Medical technology, electronic components and circuits, electronic systems, physical sciences, materials, computer programs, mechanics, machinery, manufacturing/fabrication, mathematics and information sciences, book and reports, and a special section on Laser Tech Briefs.

  12. The Chalk River Nuclear Laboratories contingency plan -a brief description

    International Nuclear Information System (INIS)

    A brief description of the contingency plan which deals with both the on-site and off-site consequences of a serious nuclear accident is given. The off-site consequences of different size releases and the subsequent action taken by employees, radiation protection experts, municipal, Provincial and Federal authorities is described and the interaction of the various groups is discussed. (author)

  13. 78 FR 9431 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2013-02-08

    ... BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board. ACTION: Notice. SUMMARY: The Merit Systems Protection Board (MSPB or Board) announces the opportunity to file amicus... Enhancement Act of 2012 (WPEA), 112 Public Law 199, may be applied retroactively to pending cases...

  14. 76 FR 59171 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2011-09-23

    ... BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board. ACTION: Notice. Overview Information Merit Systems Protection Board (MSPB or Board) Provides Notice of Opportunity To File... his employment constitutes an abridgement of his constitutional right to minimum due process of law,...

  15. 78 FR 17233 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2013-03-20

    ... BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board. ACTION: Notice. SUMMARY: The Merit Systems Protection Board (MSPB or Board) announces the opportunity to file amicus... Enhancement Act of 2012 (WPEA), 112 Public Law 199, with regard to damages may be applied retroactively...

  16. SWIFT Intensive Technical Assistance Process. Technical Assistance Brief #1

    Science.gov (United States)

    Sailor, Wayne; McCart, Amy; McSheehan, Michael; Mitchiner, Melinda; Quirk, Carol

    2014-01-01

    The national center on Schoolwide Integrated Framework for Transformation (SWIFT Center) is now approaching the halfway point in its first full year of providing intensive technical assistance (TA) to 68 schools in 20 local educational agencies across five states. The purpose of this brief is to provide a thumbnail sketch of how this TA process…

  17. A brief review of feed-forward neural networks

    OpenAIRE

    SAZLI, Murat Hüsnü

    2006-01-01

    Artificial neural networks, or shortly neural networks, find applications in a very wide spectrum. In this paper, following a brief presentation of the basic aspects of feed-forward neural networks, their mostly used learning/training algorithm, the so-called back-propagation algorithm, have been described.

  18. A Brief Introduction to Foreign Languages Education Policy in China

    Science.gov (United States)

    Zhang, Weiwen

    2012-01-01

    Based on a series of official published documents and relevant research reports, the paper make a brief introduction to foreign languages education policies in China, which included national English teaching guidance, national English language textbooks, national English curriculum standard and the massive English teachers training program, etc.…

  19. Theoretical development of information science: A brief history

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2016-01-01

    This paper presents a brief history of information science (IS) as viewed by the author. The term ‘information science’ goes back to 1955 and evolved in the aftermath of Claude Shannon’s ‘information theory’ (1948), which also inspired research into problems in fields of library science and...... have remained implicit in in the field much of the time....

  20. Organizational Culture and Internationalization: A Brief Literature Review

    Science.gov (United States)

    Nussbaumer, Alison

    2013-01-01

    This brief literature review introduces an area of emerging research about the impact of organizational culture on institutional strategies for internationalization. The review begins by introducing the concept of organizational culture, particularly within higher education. Five articles published between 2003 and 2012 are examined that introduce…

  1. A Course on Effective Teacher-Child Interactions. Research Brief

    Science.gov (United States)

    Hamre, Bridget K.; Pianta, Robert C.; Burchinal, Margaret; Field, Samuel; LoCasale-Crouch, Jennifer; Downer, Jason T.; Howes, Carollee; LaParo, Karen; Scott-Little, Catherine

    2012-01-01

    This study found that teachers who were randomly assigned to take a 14-week course on effective teacher-child interactions demonstrated significant changes in beliefs and knowledge about effective practices and provided more stimulating and engaging interactions in the classroom. [This research brief is based on: Hamre, B. K., Pianta, R. C.,…

  2. Suicide Prevention in Schools. A Center Policy Issues Analysis Brief

    Science.gov (United States)

    Center for Mental Health in Schools at UCLA, 2007

    2007-01-01

    Policy makers remain in conflict over whether schools should play a institutionalized role in preventing student suicide. This brief highlights two other major related questions that are at issue: (1) Does suicide education stigmatize some students and increase that risk of suicide ideation? and (2) Should schools be involved in monitoring…

  3. Eye Tracking: A Brief Guide for Developmental Researchers

    Science.gov (United States)

    Feng, Gary

    2011-01-01

    Eye tracking offers a powerful research tool for developmental scientists. In this brief article, the author introduces the methodology and issues associated with its applications in developmental research, beginning with an overview of eye movements and eye-tracking technologies, followed by examples of how it is used to study the developing mind…

  4. Longitudinal Construct Validity of Brief Symptom Inventory Subscales in Schizophrenia

    Science.gov (United States)

    Long, Jeffrey D.; Harring, Jeffrey R.; Brekke, John S.; Test, Mary Ann; Greenberg, Jan

    2007-01-01

    Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times…

  5. The Secret to Finland's Success: Educating Teachers. Research Brief

    Science.gov (United States)

    Sahlberg, Pasi

    2010-01-01

    In the last decade, Finland has emerged as the leading OECD country in educational achievement. In examining the sources of Finland's dramatic rise to the top, research shows one key element that has impacted Finland's success above all others: excellent teachers. This policy brief details the key elements of Finland's successful system, examining…

  6. The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report

    DEFF Research Database (Denmark)

    Jones, Allan; Clausen, Loa

    2013-01-01

    OBJECTIVE: The aim of the study was to evaluate the efficacy of a brief group cognitive behavior therapy (CBT) program in treating a large cohort of patients diagnosed with bulimia nervosa. METHOD: Treatment outcome defined as reductions in bulimia related behavioral symptoms and bulimia related ...

  7. A brief assessment of physical functioning for prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Jin-Shei Lai

    2010-06-01

    Full Text Available Jin-Shei Lai1, Rita Bode2, Hwee-Lin Wee3, David Eton4, David Cella11Department of Medical Social Sciences, 2Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, IL USA; 3Department of Pharmacy, National University of Singapore, Singapore; 4Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAAbstract: We aimed to validate a more rapid, yet reliable means of assessing physical function (PF for patients with prostate cancer. The sample included 128 prostate cancer patients recruited from urology and general oncology clinics at two Chicago-area hospitals. The main outcome measures were: A 36-item PF item bank that included a 5-item short form (BriefPF and the 10-item PF subscale (PF-10 from the Medical Outcomes Study SF-36. Validity, information function, and relative precision (calculated using Rasch analysis and raw scores of the BriefPF were compared to the PF-10 and the full PF item bank. We found that the BriefPF and PF-10 were strongly correlated (r = 0.85 with the PF bank, and all three scales differentiated patients according to performance status (FPF bank(2,124 = 32.51 P < 0.001, FPF-10(2,121 = 27.35 P < 0.001, FBriefPF (2,123 = 38.40 P < 0.001. BriefPF has excellent precision relative to the PF-10 in measuring patients with different performance status levels. The Rasch-based information function indicated that the BriefPF was more informative than PF-10 in measuring moderate to higher functioning patients. Hence, the BriefPF offers a parsimonious and precise measure of PF for use among men with prostate cancer, and may aid in the timely inclusion of patient-reported outcomes in treatment decision-making.Keywords: quality-of-life, item bank, short-form, Medical Outcomes Study

  8. The effect of briefing videos in medical simulation-based education: a randomised controlled trial

    OpenAIRE

    Tetering, van, A.; Truijens, S. E. M.; Hout-van der Jagt, van der, MB Beatrijs; Wijsman, J.L.P.; Oei, S. G.

    2014-01-01

    The aim of this study is to compare the effects of an affective briefing video with a textual briefing on cognitive appraisal (threat or challenge response). It is hypothesized that briefing videos will cause a threat response, which is associated with increase in cortisol and memory consolidation.

  9. Participation in Vocational Education and Training to Age 24. LSAY Briefing Number 17

    Science.gov (United States)

    Rothman, Sheldon

    2008-01-01

    The data for this "Briefing" are from the 1995 cohort of the Longitudinal Surveys of Australian Youth (LSAY). The findings reported here are from three recent LSAY research reports, which are listed at the end of this "Briefing". The cohort comprises young people who were in Year 9 at school in 1995. Data in this "Briefing" have been collected…

  10. Research and development at Kernforschungszentrum Karlsruhe - brief report 1991

    International Nuclear Information System (INIS)

    Research at Kernforschungszentrum Karlsruhe in the nineties is focussed on environmentally compatible high technologies with emphasis on environmental engineering, power engineering, microsystems technology, and selected fields of fundamental research. The KfK research and development trends are reflected by this brief report. The facts and figures inform researchers and specialists by summarizing the major results of the current research projects and by informing about the main targets and trends of long-time research programs and individual projects. The brief reports are completed by comprehensive, annual progress reports which discuss the implementation and results of the KfK research activities and compile references which list the various scientifico-technical reports, contributions to journals, conference papers, and other publications. (orig.)

  11. Reducing HIV stigma among nursing students: a brief intervention.

    Science.gov (United States)

    Shah, Shilpa M; Heylen, Elsa; Srinivasan, Krishnamachari; Perumpil, Sheeja; Ekstrand, Maria L

    2014-11-01

    HIV stigma can be devastating and is common among health care providers, particularly nurses. The objectives of this study were to (a) assess the acceptability and feasibility of a brief stigma-reduction curriculum among a convenience sample of Indian nursing students and (b) examine the preliminary effect of this curriculum on their knowledge, attitudes, and intent to discriminate. At baseline, 57% of students had at least one misconception about HIV transmission, 38% blamed people living with HIV for their infection, and 87% and 95% demonstrated intent to discriminate while dispensing medications and drawing blood, respectively. Following the curriculum, HIV-related knowledge increased while blame, endorsement of coercive policies, and intent to discriminate decreased significantly. In addition, more than 95% of participants described the curriculum as practice changing. This brief intervention resulted in decreased stigma levels and was also highly acceptable to the nursing students. Next steps include rigorous evaluation in a randomized controlled trial. PMID:24569699

  12. Black holes as particle accelerators: a brief review

    International Nuclear Information System (INIS)

    Rapidly rotating Kerr black holes can accelerate particles to arbitrarily high energy if the angular momentum of the particle is fine-tuned to some critical value. This phenomenon is robust as it is founded on the basic properties of geodesic orbits around a near-extremal Kerr black hole. On the other hand, the maximum energy of the acceleration is subjected to several physical effects. There is convincing evidence that the particle acceleration to arbitrarily high energy is one of the universal properties of general near-extremal black holes. We also discuss gravitational particle acceleration in a more general context. This article is intended to provide a pedagogical introduction to and a brief overview of this topic for non-specialists. (brief review)

  13. Substance Use Screening, Brief Intervention, and Referral to Treatment.

    Science.gov (United States)

    2016-07-01

    The enormous public health impact of adolescent substance use and its preventable morbidity and mortality show the need for the health care sector, including pediatricians and the medical home, to increase its capacity related to substance use prevention, detection, assessment, and intervention. The American Academy of Pediatrics published its policy statement "Substance Use Screening, Brief Intervention, and Referral to Treatment for Pediatricians" in 2011 to introduce the concepts and terminology of screening, brief intervention, and referral to treatment (SBIRT) and to offer clinical guidance about available substance use screening tools and intervention procedures. This policy statement is a revision of the 2011 SBIRT statement. An accompanying clinical report updates clinical guidance for adolescent SBIRT. PMID:27325638

  14. A brief history of the philosophy of time

    CERN Document Server

    Bardon, Adrian

    2013-01-01

    Adrian Bardon's A Brief History of the Philosophy of Time is a short introduction to the history, philosophy, and science of the study of time-from the pre-Socratic philosophers through Einstein and beyond. A Brief History of the Philosophy of Time covers subjects such as time and change, the experience of time, physical and metaphysical approaches to the nature of time, the direction of time, time travel, time and freedom of the will, and scientific and philosophical approaches to eternity and the beginning of time. Bardon employs helpful illustrations and keeps technical language to a minimum in bringing the resources of over 2500 years of philosophy and science to bear on some of humanity's most fundamental and enduring questions.

  15. A brief overview of the Civil Union Act

    OpenAIRE

    N Ntlama

    2010-01-01

    The adoption of the Constitution of the Republic of South Africa, 1996 (the Constitution) has provided a sound framework for the elimination of discrimination and prejudice against all members of our society. The Constitution provides for equal recognition of the right to freedom of religion and sexual orientation within the framework of the right to equality. This note aims to provide a brief overview and analysis of the general and potentially problematic features of the C...

  16. D2.4. Briefing paper for first workshop

    OpenAIRE

    Watson, Hayley; Wadhwa, Kush; van Os, Nico; Dekkers, Chris; Baruh, Lemi; Papadimitriou, Alex

    2015-01-01

    EXECUTIVE SUMMARY This briefing paper provides an overview of the key findings from the completion of three reports relating to the use of new media in crisis situations that have been completed as part of the COSMIC project. COSMIC, “Contribution of Social Media in Crisis management”, is a two-year project that is funded under the European Commission's Seventh Framework Programme FP7-SEC-2012 under grant agreement no. 312737. The first report, D2.1, identified existin...

  17. FISHING IN SINALOA: BRIEF HISTORY AND SEARCH OF EPISTEME

    OpenAIRE

    Ramón Enrique Morán-Angulo; Luis Miguel Flores-Campaña

    2015-01-01

    This paper reports from bibliographic woven into three sections: a brief history of the prehispanic fishing, where the encounter between the indigenous communities of the State of Sinaloa and species that supported the incursion of primitive society in the various ecosystems are described water that make up the vast and varied territory of Sinaloa, where fishing is born as a function of interaction between society and nature through a deep empirical knowledge and a handmade primitive instrume...

  18. Brief report on Open Praxis dissemination, abstracting and impact

    Directory of Open Access Journals (Sweden)

    Inés Gil-Jaurena

    2014-07-01

    Full Text Available The editorial project for the relaunching of Open Praxis as the ICDE scholarly, peer-reviewed and open access journal included three main aspects: editorial process, scientific quality and dissemination. After 6 published issues in 2013 and 2014, this editorial focuses on the last aspect, related to visibility, providing a brief report on the actions developed to promote Open Praxis. A second part introduces the nine papers included in the issue.

  19. Does cognitive perception have access to brief temporal events?

    OpenAIRE

    Hess, Robert F.; Maehara, Goro

    2011-01-01

    To determine whether conscious perception has access to brief temporal event, we asked subjects in an odd-man out paradigm to determine which of the four Gaussian blobs was flickering asynchronously in time. We measure synchrony thresholds as a function of the base temporal frequency for spatially scaled stimuli in foveal and peripheral vision. The results are consistent with a time delay of around 67 milliseconds (ms) for foveal vision and 91 ms for peripheral vision. We conclude that consci...

  20. A brief social history of astrobiology in Ibero-america

    CERN Document Server

    Lemarchand, Guillermo A

    2010-01-01

    The work is divided into three sections: the first one describes the historical evolution of the main arguments presented about the plurality of inhabited worlds, from the presocratics to the birth of modern science. The second section analyzes the race to define the search for life beyond Earth as a scientific activity under a specific name. Finally, the third part presents a brief description of the social history of science that allowed the early development of astrobiology in Iberoamerica.

  1. Guessing personality from a brief sample of behaviour

    OpenAIRE

    Wu, Wenjie

    2015-01-01

    Mentalising as a process for explaining and predicting behavior relates to inferring mental states and traits of others. Previous research of mentalising has focused too heavily on mental states and insufficiently on personality traits. Given this context, the current thesis aimed to explore the phenomenon of forming first impressions of personality based on a brief sample of behavior. In the current research, after being filmed in diverse naturalistic scenarios, targets filled in an “emp...

  2. Predictors of outcome in brief cognitive behavior therapy for schizophrenia.

    Science.gov (United States)

    Brabban, Alison; Tai, Sara; Turkington, Douglas

    2009-09-01

    Antipsychotic medications, while effective, often leave patients with ongoing positive and negative symptoms of schizophrenia. Guidelines recommend using cognitive behavior therapy (CBT) with this group. Clearly, mental health professionals require training and supervision to deliver CBT-based interventions. This study tested which antipsychotic-resistant patients were most likely to respond to brief CBT delivered by psychiatric nurses. Staff were trained over 10 consecutive days with ongoing weekly supervision. Training for carers in the basic principles of CBT was also provided. This article represents the secondary analyses of completer data from a previously published randomized controlled trial (Turkington D, Kingdon D, Turner T. Effectiveness of a brief cognitive-behavioural therapy intervention in the treatment of schizophrenia. Br J Psychiatry. 2002;180:523-527) (n = 354) to determine whether a number of a priori variables were predictive of a good outcome with CBT and treatment as usual. Logistic regression was employed to determine whether any of these variables were able to predict a 25% or greater improvement in overall symptoms and insight. In the CBT group only, female gender was found to strongly predict a reduction in overall symptoms (P = .004, odds ratio [OR] = 2.39, 95% confidence interval [CI] = 1.33, 4.30) and increase in insight (P = .04, OR = 1.84, 95% CI = 1.03, 3.29). In addition, for individuals with delusions, a lower level of conviction in these beliefs was associated with a good response to brief CBT (P = .02, OR = 0.70, 95% CI = 0.51, 0.95). Women with schizophrenia and patients with a low level of conviction in their delusions are most likely to respond to brief CBT and should be offered this routinely alongside antipsychotic medications and other psychosocial interventions. PMID:19571248

  3. Bayesian Nonparametrics in Topic Modeling: A Brief Tutorial

    OpenAIRE

    Spangher, Alexander

    2015-01-01

    Using nonparametric methods has been increasingly explored in Bayesian hierarchical modeling as a way to increase model flexibility. Although the field shows a lot of promise, inference in many models, including Hierachical Dirichlet Processes (HDP), remain prohibitively slow. One promising path forward is to exploit the submodularity inherent in Indian Buffet Process (IBP) to derive near-optimal solutions in polynomial time. In this work, I will present a brief tutorial on Bayesian nonparame...

  4. Nucleon pair approximation of the shell model: a brief review

    International Nuclear Information System (INIS)

    We present a brief introduction of the nucleon pair approximation (NPA) of the shell model in this paper. We review our recent calculated results which include level spectra and electromagnetic properties of low-lying states, by applying the NPA to even-even nuclei and to odd-A nuclei. We also apply this method to a few schematic systems such as single-j shell, to investigate the validity of SD-pair truncation of the shell model. (author)

  5. A brief scenario about the ''space pollution'' around the Earth

    International Nuclear Information System (INIS)

    In this work is presented a brief review about the main events generating of space debris around the Earth, occurred up to the present day. How the clouds of debris ''polluted'' the neighborhood of orbits in which the bodies were initially allocated is here analyzed. The implications of the growth of space debris existing on space missions as well as safety rules to control sources of debris are discussed

  6. The pionic Drell–Yan process: a brief survey

    International Nuclear Information System (INIS)

    The Drell–Yan process is an invaluable tool for probing the structure of hadrons, and the pion-induced Drell–Yan process is unique in its sensitivity to several subtleties of the partonic structure. This is a brief review of the pionic Drell–Yan process with particular emphasis on the dilepton angular distributions and nuclear modification of the parton distributions (the EMC effect). (author)

  7. Manpower System Analysis Thesis Day Brief / Class of March 2015

    OpenAIRE

    2015-01-01

    Brief. Includes these presentations: Improving the Signal for U.S. Navy Officer Productivity by LCDR Josh Ellison, Comparing the Performance of the Resident to Distance Learning Student Navy Officers at Naval Postgraduate School by Kyle Alcock, Analysis of Suicide Behaviors in the Navy Active Duty and Reserve Component Population by LCDR Serena Blankenship & LCDR Kristin Shepherd, Pre-Accession Factors in the Performance and Retention of Hispanic Navy Enlistees by LTJG Ryan Bow...

  8. A Brief Review & Introduction to Practiced Islamic Banking & Finance

    OpenAIRE

    Shaikh, Salman

    2010-01-01

    This paper looks at the practiced Islamic finance and alternatives it offers for corporate finance managers in sourcing funds i.e. i) Ijara ii) Murabaha iii) equity modes like Musharakah and Mudarabah iv) Diminishing Musharakah, v) Salam and vi) Istisna. It also looks at alternatives for sourcing funds from savers to provide financing thereof by financialintermediaries i.e. i) Qard-e-Hasan ii) Musharakah and iii) Mudarabah. The paper also gives a brief account of literature on Islamic corpora...

  9. Reducing cardiovascular arousal to psychological stress with brief physical exercise

    OpenAIRE

    Chafin, Sky

    2007-01-01

    We test if brief physical exercise can reduce cardiovascular arousal not just during a psychological stressor, as prior studies suggest, but both before it occurs, when one is anticipating the stressor, and after it occurs, when one is ruminating about it. Including both anticipatory and recovery responses may be more consistent with how individuals use exercise to cope with stress. It is also relevant to an expanded view of the cardiovascular reactivity hypothesis, which suggests that the du...

  10. Individual Investment Behaviour: A Brief Review Of Research

    OpenAIRE

    Collard, Sharon

    2009-01-01

    This brief review of research was carried out to inform whether the Personal Accounts Delivery Authority (PADA) should be making decisions for its members with regard to pension fund choices. The findings are based on a review of around 80 items, mostly involving research carried out in the US and UK. The body of evidence mainly comes from the discipline of economics and the field of behavioural economics in particular. Survey data was the most common type of evidence, but the review included...

  11. A BRIEF VIEW ON ANTIHYPERTENSIVE DRUGS DELIVERY THROUGH TRANSDERMAL PATCHES

    OpenAIRE

    V. Rastogi*, Pragya, P. Upadhyay

    2012-01-01

    Transdermal Drug Delivery System (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. Hypertension is one of the common disorder for the mankind. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The present article delivers a brief view on the work been done to increase the bioavailability of various anti...

  12. An unusual presentation of brief recurrent psychosis: a case report

    OpenAIRE

    Krishnamurthy CN; Sanivarapu, Sravanti L.

    2012-01-01

    Background: Although the term "zycloiden psychosen" was first used by Karl Kleist in 1926 to group together disorders, which had presented with sudden onset, brief episodic course, polymorphous psychotic symptoms and good inter-episode recovery, its origin can be traced back to 1880s. Despite its existence in the community, for so long, the diagnosis of cycloid psychosis is only seldom made, making it a unique disorder. Hence, there seems to be lack of awareness of this rare entity even among...

  13. The Economic Consequences of Terror: A Brief Survey

    OpenAIRE

    Tilman Brück; Bengt-Arne Wickström

    2004-01-01

    This brief survey reviews the economic consequences of terrorism. It is argued that the indirect effects of terrorism are likely to outweigh the direct effects. The former include changes in risk, transaction costs, demand, public finances and growth. We also address the nature of anti-terrorist policy and of policies reducing the negative impact of terrorism. The former can change the incentives for terrorists to break with social conventions or maximize the costs of conducting terrorism. Th...

  14. Stereoselectively fluorinated N-heterocycles: a brief survey

    OpenAIRE

    Hu, Xiang-Guo; Hunter, Luke

    2013-01-01

    The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal chemistry and organocatalysis. This brief review will examine some of the effects that fluorine substitution can have in N-heterocycles, including changes to the molecules’ stability, their conformational behaviour, their hydrogen bonding ability, an...

  15. Stereoselectively fluorinated N-heterocycles: a brief survey

    OpenAIRE

    Xiang-Guo Hu; Luke Hunter

    2013-01-01

    The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties. These changes can be rationally exploited for the benefit of diverse fields such as medicinal chemistry and organocatalysis. This brief review will examine some of the effects that fluorine substitution can have in N-heterocycles, including changes to the molecules’ stability, their conformational behaviour, their hydrogen bonding ability, an...

  16. A brief history of vaccines & vaccination in India

    OpenAIRE

    Chandrakant Lahariya

    2014-01-01

    The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace ...

  17. A Brief Analysis on Empty Categories in Chinese

    Institute of Scientific and Technical Information of China (English)

    XIONG Shao-li

    2014-01-01

    This paper aims to give a brief analysis on the Empty Categories in Chinese. It will first illustrate Chomsky ’s classifica-tion of EC as well as the constraints the subject to briefly, then basing on this classification the author will state some of Chinese scholars’study and research including Xu Liejiong , Huang Zhengde and Hu Jianjun. Finally, the author will compare these clas-sic frameworks and attempt to.

  18. The early impact of therapeutic alliance in brief psychodynamic psychotherapy

    OpenAIRE

    Marcolino José Alvaro Marques; Iacoponi Eduardo

    2003-01-01

    INTRODCTION: Therapeutic alliance is a key component of the psychotherapeutic process. This study estimated the impact of the therapeutic alliance as measured by CALPAS-P in an individual brief psychodynamic psychotherapy program. METHODS: To study the impact of the therapeutic alliance patients in psychotherapy answered to the CALPAS-P at the first and third session and to the Self-report Questionnaire (SRQ-20), to the Beck Depression Inventory (BDI) and to the Hamilton Anxiety Scale at the ...

  19. A brief psychological intervention that reduces adolescent alcohol consumption.

    OpenAIRE

    Armitage, Christopher J.; Rowe, Richard; Arden, Madelynne; Harris, Peter R.

    2014-01-01

    Objective: Alcohol consumption in adolescence is associated with problem drinking in later life, and there is a need to develop evidence-based interventions to reduce adolescent alcohol consumption. The aims of the present study were to test the ability of a very brief intervention based on self-affirmation theory to reduce alcohol consumption in a sample of adolescents and to examine potential mediators of the effects. Method: 67 adolescents were randomly allocated either to form a self-affi...

  20. Briefing book on environmental and waste management activities

    International Nuclear Information System (INIS)

    The purpose of the Briefing Book is to provide current information on Environmental Restoration and Waste Management Activities at the Hanford Site. Each edition updates the information in the previous edition by deleting those sections determined not to be of current interest and adding new topics to keep up to date with the changing requirements and issues. This edition covers the period from October 15, 1992 through April 15, 1993

  1. A New Brief Measure of Oral Quality of Life

    Directory of Open Access Journals (Sweden)

    Nancy R. Kressin, PhD

    2008-04-01

    Full Text Available IntroductionWe developed a brief measure of the impact of oral conditions on individual functioning and well-being, known as oral quality of life.MethodsAmong older male veterans (N = 827 and community dental patients (N = 113, we administered surveys consisting of extant oral quality of life items, using clinical dental data from the veteran samples. We assigned each oral quality of life item to a theoretical dimension, conducted an iterative series of multitrait scaling analyses to examine the item-fit with the dimensions, reduced the number of items, and examined the psychometric characteristics of new scales and their association with clinical indices.ResultsWe developed two brief oral quality of life scales, one consisting of 12 items and the other of 6, the latter a subset of the former. Each demonstrated sound psychometric properties and was sensitive to clinical indices.ConclusionThe two brief oral quality of life scales can be used to assess the population-based impact of oral conditions as well as outcomes of dental care.

  2. Xeroderma Pigmentosum: A Bane in developing country – Brief report

    Directory of Open Access Journals (Sweden)

    Hari Kishan Kumar Yadalla

    2014-10-01

    Full Text Available Xeroderma pigmentosum (XP is a rare autosomal recessive disorder characterized by photosensitivity, cutaneous pigmentary changes, premature skin ageing, and the development of various cutaneous and internal malignancies at an early age. We present this case of a 10 year-old girl in a developing country like India, with significant corneal scarring and multiple cutaneous skin lesions in sun-exposed areas. Developmental delay had been present since 3 months of age, with these clinical features it was consistent with Xeroderma Pigmentosum. We highlight the difficulties encountered due to the lack of diagnostic and treatment modalities for this child, and offer a brief review of XP, including emerging treatments.

  3. Towards the European strategy for particle physics the Briefing Book

    CERN Document Server

    Åkesson, T; Allanach, Benjamin C; Bertolucci, S; Blondel, A; Butterworth, J; Cavalli-Sforza, M; Cervera-Villanueva, Anselmo; Davidson, S; De Naurois, Mathieu; Desch, K; Egede, U; Glover, N; Heuer, R D; Huber, P; Höcker, A; Jungmann, K; Landua, Rolf; Le Goff, J M; Linde, Frank L; Lombardi, A; Mangano, Michelangelo L; Mezzetto, M; Onderwater, G; Palanque-Delabrouille, Nathalie; Peach, Kenneth J; Polosa, A; Rondio, E; Webber, Bryan R; Weiglein, G; Womersley, J; Wurr, K

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates material presented and discussed during the Symposium on the European Strategy for Particle Physics, held in Orsay from 30th January to 2nd February 2006, reflecting the various opinions of the European community as recorded in written submissions to the Strategy Group and in the discussions at the Symposium.

  4. Loss of interim status (LOIS) under RCRA. RCRA Information Brief

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-01

    The Resource Conservation and Recovery Act (RCRA) requires owners and operators of facilities that treat store, or disposal of hazardous waste (TSDFs) to obtain an operating permit. Recognizing that it would take EPA many years to issue operating permits to all RCRA facilities, Congress created ``interim status`` under Section 3005(e) of the Act. Interim status allows facilities to operate under Subtitle C of RCRA until their permits are issued or denied. This information brief defines interim status and describes how failure to meet interim status requirements may lead to loss of interim status (LOIS).

  5. Operations research at CSIR: A brief history through cases

    Directory of Open Access Journals (Sweden)

    HW Ittmann

    2007-06-01

    Full Text Available Apart from work in the mining industry during the 1950s, the first real Operations Research (OR group in South Africa was established at CSIR in the early 1960s. Those initially involved in this group played a significant role in establishing OR at various universities in South Africa. The OR group at CSIR did, however, continue and today the group still exists. This paper presents a brief history of this group and endeavours to provide a glimpse of some of the projects conducted over the many years since its establishment.

  6. Operations research at CSIR: A brief history through cases

    OpenAIRE

    HW Ittmann; FE van Dyk; IA Meyer; SJJ van Rensburg

    2007-01-01

    Apart from work in the mining industry during the 1950s, the first real Operations Research (OR) group in South Africa was established at CSIR in the early 1960s. Those initially involved in this group played a significant role in establishing OR at various universities in South Africa. The OR group at CSIR did, however, continue and today the group still exists. This paper presents a brief history of this group and endeavours to provide a glimpse of some of the projects conducted over the ma...

  7. Examining the performance of the brief addiction monitor.

    Science.gov (United States)

    Nelson, Karl G; Young, Kevin; Chapman, Heather

    2014-04-01

    The Center for Excellence in Drug Abuse Treatment and Education (Center for Excellence in Substance Abuse Treatment and Education (CESATE; 2010). Brief Addiction Monitor: Manual of Operations. Philadelphia, PA) recently suggested that Veterans Affairs' (VA) addictions treatment programs, in order to encourage measurement based care, begin using a new measure of substance abuse, the Brief Addictions Monitor (BAM). To date, only one study Caccolia et al, 2013. Development and initial evaluation of the Brief Addiction Monitor (BAM). Journal of Substance Abuse Treatment, 44, 256-63. doi: http://dx.doi.org/10.1016/j.jsat.2012.07.013) has examined the psychometric properties of a version of this instrument. However, this study did not use the version of the BAM currently available to most VA providers via the mental health assistant software; rather, the authors reported the properties of a BAM where most of the items had continuous (or near continuous) response options. The current study seeks to provide data on the version of the BAM which uses 5 point Likert scale response options for its questions, the version available on the mental health assistant software. Based on data from more than 700 veterans enrolled in out-patient (OP) and in-patient (IP) addictions treatment programs, this study examined the factor structure, reliability, and validity of this version of the BAM. Across both groups, results suggested that the BAM lacked a reliable factor structure, in contrast to the findings from the earlier study. However, a single scale, composed of a minority of items on the BAM, showed promise. A minority of the items (five) provided valid information across both OP and IP samples when applied individually, as indicated by convergent and divergent validity comparisons with other measures of functioning; tracking changes in functioning over the course of treatment; and correlating with changes in convergent and divergent validity measures. This partially supported the

  8. Brief to the Cluff Lake Board of Inquiry

    International Nuclear Information System (INIS)

    The purpose of this brief is to describe the structure and operations of the Atomic Energy Control Board, and to indicate how these relate to current activities and to possible future developments with respect to the nuclear fuel cycle. The problem areas from the regulatory viewpoint may be identified as follows: protection of the health of workers and the public; protection of the environment; the safe use of nuclear materials, equipment and technology for peaceful and lawful purposes. The attention of regulatory authorities has been focused on all these areas, perhaps without much public awareness, but today the increasing public concern necessitates a parallel increase in public information and participation

  9. A brief outline of the top-BESS model

    CERN Document Server

    Gintner, Mikulas; Melo, Ivan

    2011-01-01

    This is a brief outline of the top-BESS model and its properties. The top-BESS model is the higgsless effective description of the strong electroweak symmetry breaking with a single new SU(2)_L+R triplet vector resonance. In contrast with the universality of the fermion interactions of the BESS model, the top-BESS vector resonance couples directly to the third quark generation only. The complete formulation of the model along with its phenomenology can be found in arXiv:1107.0570.

  10. A Brief Introduction to Astronomy in the Middle East

    CERN Document Server

    Steele, John M

    2012-01-01

    The Middle East is the birthplace of astronomy and the centre for its development during the medieval period. In this brief introduction John Steele offers an intriguing insight into Middle Eastern achievements in astronomy and their profound influence on the rest of the world. Amongst other things, the book traces the Late Babylonians' ingenious schemes for modelling planetary motion. It also reveals how medieval Islamic advances in the study of the heavens, and the design of precise astronomical instruments, led to breakthroughs by Renaissance practitioners such as Copernicus and Kepler. An

  11. A brief account of Julius Planer's life and research

    Directory of Open Access Journals (Sweden)

    R. Bilyy

    2010-01-01

    Full Text Available A brief account of the life and research activities of Julius Planer is presented. Professor Planer is a scientist who lived one and half century ago. However, his studies, in particular, during the years when he headed Department of Anatomy at Universität in Lemberg, nowadays known as the Ivan Franko National University of Lviv in Ukraine, were essential to a modern understanding of liquid crystals. While working at Lviv University, Planer also made several landmark contributions to biomedical science.

  12. ROMANIAN AERONAUTICAL METEOROLOGY APPLICABLE LEGAL FRAMEWORK –BRIEFING

    Directory of Open Access Journals (Sweden)

    CATALIN POPA

    2012-05-01

    Full Text Available The purpose of this briefing is toprovide an overview of the aeronautical meteorology legal framework in Romania. In this context, the role and importance of aeronautical meteorology in international air traffic management will be underlined, with focus on the civil aviation activity in Romania. The international legal framework and modalities of implementing these rules at national level will constitute a significant part of the present study., Specific accent will be put on the national regulatory framework and structure, means of updating it, and how it responds to changing regulatory requirements.

  13. Brief-stimulus presentations on multiform tandem schedules

    OpenAIRE

    Reed, Phil

    1994-01-01

    Three experiments examined the influence of a brief stimulus (a light) on the behavior of food-deprived rats whose lever pressing on tandem schedules comprising components of different schedule types resulted in food presentation. In Experiment 1, either a tandem variable-ratio variable-interval or a tandem variable-interval variable-ratio schedule was used. The variable-interval requirement in the tandem variable-ratio variable-interval schedule was yoked to the time taken to complete the va...

  14. Time course of conflict processing modulated by brief meditation training

    Directory of Open Access Journals (Sweden)

    Yaxin eFan

    2015-07-01

    Full Text Available Resolving conflict is a pivotal self-control ability for human adaptation and survival. Although some studies reported meditation may affect conflict resolution, the neural mechanisms are poorly understood. We conducted a fully randomized 5 hours trial of one form of mindfulness meditation - Integrative Body-Mind Training (IBMT in comparison to a relaxation training control. During the Stroop word-color task, IBMT group produced faster resolution of conflict, a smaller N2 and an earlier and larger P3 component of the event-related brain potentials (ERPs. These results indicate that brief meditation training induces a brain state that improves the resolution of conflict.

  15. Brief review: sleep health and safety for transportation workers

    Directory of Open Access Journals (Sweden)

    Quan SF

    2015-03-01

    Full Text Available Accidents related to sleepiness related fatigue are an important concern in transportation related industries. This brief review outlines the public safety concerns with sleepiness related fatigue in the railroad, aviation and motor vehicle transportation fields. In addition, the common causes of sleepiness related fatigue, and impact on operators and their families are highlighted. It is suggested that in addition to greater recognition and changes in duty hour regulations, there should be a greater emphasis on the education of operators on the importance of sleep and circadian factors in causing fatigue, as well as strategies to mitigate their impact.

  16. Bikes and Movies: A Brief History Of Motorcycle In Cinema

    OpenAIRE

    Sandra Martinez; Antonio Sanjuán

    2014-01-01

    Bikers, gangs, heroes and villains, cops, races... after an exhaustive compilation and categorization fo more than 2.500 movies, this article explores the biker image on films through the most representatives.This is a brief review of the motorcycle use from the Early Cinema to the end of the 20th century, highlighting the fifties and seventies. Some movies of those years marked the biker genre and the biker and gang aesthetics, both in costume and in the way they relate to the world. Also th...

  17. Radiation Retinopathy Is Treatable With Anti-Vascular Endothelial Growth Factor Bevacizumab (Avastin)

    International Nuclear Information System (INIS)

    Purpose: To report on bevacizumab treatment for radiation retinopathy affecting the macula. Patients and Methods: Twenty-one patients with radiation retinopathy (edema, hemorrhages, capillary dropout, and neovascularization) and a subjective or objective loss of vision were treated. Treatment involved intravitreal injection of bevacizumab (1.25 mg in 0.05 mL) every 6-12 weeks. Treatment was discontinued at patient request or if there was no measurable response to therapy. Main outcome measures included best corrected visual acuity, ophthalmic examination, retinal photography, and angiography. Results: Bevacizumab treatment was followed by reductions in retinal hemorrhage, exudation, and edema. Visual acuities were stable or improved in 86% (n = 18). Three patients discontinued therapy. Each was legally blind before treatment (n = 1), experienced little to no subjective improvement (n = 2), or was poorly compliant (n = 2). Three patients (14%) regained 2 or more lines of visual acuity. No ocular or systemic bevacizumab-related side effects were observed. Conclusions: Intravitreal bevacizumab can be used to treat radiation retinopathy. In most cases treatment was associated with decreased vascular leakage, stabilization, or improved vision. An anti-vascular endothelial growth factor strategy may reduce tissue damage associated with radiation vasculopathy and neuropathy

  18. Intravitreal avastin for choroidal neovascularization associated with stargardt-like retinal abnormalities in pseudoxanthoma elasticum

    Directory of Open Access Journals (Sweden)

    Querques Giuseppe

    2010-01-01

    Full Text Available The aim of the study was to describe a patient with pseudoxanthoma elasticum (PXE, showing Stargardt-like retinal abnormalities, who underwent treatment with intravitreal bevacizumab for subfoveal choroidal neovascularization (CNV of the right eye (RE. A 57-year-old woman with diagnosis of angioid streaks, retinal flecks, and chorioretinal Stargardt-like atrophy due to PXE was referred to our department for sudden decreased vision in her RE (20/160. Upon a complete ophthalmologic examination, including fluorescein angiography (FA, and optical coherence tomography (OCT, the patient was diagnosed with subfoveal CNV of the RE. Owing to the subfoveal localization of the CNV, the patient was submitted to intravitreal bevacizumab injection. At the 1-month follow-up, visual acuity (VA improved (20/40, and FA and OCT revealed the CNV closure. Twelve months after the treatment, the patient′s VA remained stable with no recurrence of active CNV. On the basis of our findings, a single intravitreal bevacizumab injection seems to induce total regression of CNV complicating PXE, in a patient showing Stargardt-like retinal abnormalities. Further investigations are required to confirm our results.

  19. STS-99 / Endeavour SRTM Science Briefing and Applications from JSC

    Science.gov (United States)

    2000-01-01

    The primary objective of the STS-99 mission was to complete high resolution mapping of large sections of the Earth's surface using the Shuttle Radar Topography Mission (SRTM), a specially modified radar system. This radar system produced unrivaled 3-D images of the Earth's Surface. This videotape shows a science press briefing. The panel members are Michael Kobrick, the SRTM Project Scientist at JPL; Thomas Henning, SRTM Program Manager at the National Imagery and Mapping Agency; Diane Evans, the Director of the Earth Sciences Program at NASA; and Marian Werner, XSAR Project Manager for the DLR, Deutschen Zentrum fur Luft- und Raumfahrt, Germany's National Aerospace Research Center. Michael Kobrick explained the mechanics of interferometric measurements of the Earth. He explained and demonstrated with a scale model the deployable mast's use. He also explained the importance of the attitude and orbit determination avionics. A brief animated video showing how four beams would give a 225 km wide swath of the Earth topography was viewed. Thomas Henning discussed some of the usage of the digital terrain elevation data for flood relief planning, cell phone station placement, military planning for command and control centers, and flight simulation. He explained that public access to the most precise data would be limited. Diane Evans described data usage in flood prediction, earthquake fault identification and archeology. Marian Werner described the German and Italian input to the project. The questions from the press concerned the time to process this data, and the reasons for the limited access to the more precise data.

  20. A departmental brief to the Ontario Nuclear Safety Review

    International Nuclear Information System (INIS)

    The major nuclear activity in Canada is that associated with the generation of electricity by nuclear power stations. This area is in part subject to federal jurisdiction under the authority of the Atomic Energy Control Board. Environment Canada can play a significant role in influencing decisions regarding environmental aspects of nuclear energy development. The Department believes that the best way to preserve the quality of the environment is to anticipate and prevent problems before they arise. However, even if all precautionary measures were taken in the design and operating procedures of nuclear power stations, accidents can occur and radionuclides and toxic pollutants may escape and disperse into the environment. This brief outlines the rationale for Environment Canada's involvement and role in the nuclear area, and the major programs and activities of the Department with respect to environmental protection and emergency preparedness. The brief also makes recommendations for consideration of environmental protection technologies for nuclear power stations, for improved measurement and modelling capabilities relating to release and dispersion of radionuclides during accident conditions, and for improved communication with the public following a nuclear emergency. Environment Canada recommends that an appropriate environmental review process be undertaken for new or expanded nuclear facilities in Ontario