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Sample records for avastin gbm briefing

  1. GBM Spectral Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — For GBM, input is daily or trigger CSPEC or CTIME file from Fermi archive and corresponding response file from our archive. For LAT, input is daily spectrum file...

  2. GBM Accreting Pulsar Histories

    Data.gov (United States)

    National Aeronautics and Space Administration — For each source we plot the history of pulse frequency and pulsed flux measured using the Fermi Gamma-Ray Burst Monitor (GBM) NaI detectors. For these measurements...

  3. FERMIGTRIG - Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by one or more of the 14 GBM detectors (12 NaI and 2 BGO). Note that there are two Browse catalogs resulting from GBM...

  4. Intravitreal Bevacizumab (Avastin Injection for Neovascular Glaucoma

    Directory of Open Access Journals (Sweden)

    Shahin Yazdani

    2008-12-01

    Full Text Available

    PURPOSE: To report two cases with neovascular glaucoma secondary to ischemic central retinal vein occlusion (CRVO who were treated with intravitreal bevacizumab. CASE REPORT: Two patients were referred for neovascular glaucoma following CRVO. Visual acuity was light perception. Both eyes had extensive iris neovascularization (NVI, synechial angle closure and high intraocular pressure (IOP in spite of anti-glaucoma medications. After obtaining informed consent, both eye received an intravitreal injection of 2.5 mg (0.1 ml bevacizumab (Avastin. Both eyes demonstrated dramatic IOP reduction together with decreased severity and extent of NVI during 4 weeks of follow up. Visual acuity remained unchanged. CONCLUSION: Despite the dramatic short-term response in terms of IOP reduction and regression of neovascularization, due to limited clinical experience, one should consider this novel indication for bevacizumab cautiously.

  1. Magnetar Observations in the Swift-Fermi/GBM Era

    Science.gov (United States)

    Kouveliotou, Chryssa

    2010-01-01

    NASA's Fermi Observatory was launched June 11, 2008; the Fermi Gamma Ray Burst Monitor (GBM) began normal operations on July 14, about a month after launch, when the trigger algorithms were enabled. Since then, and against all odds, GBM recorded over 600 bursts from 4 SGRs. Of these four sources, only one was an old magnetar: SGR J1806+20. SGR J0501+4516, was discovered with Swift and extensively monitored with GBM. A source originally classified as AXP 1E1547.0-5408 exhibited SGR-like bursting behavior and we reclassified it as SGR J1550-5418. Finally, GBM discovered SGR J0418+5729 on 2009 June. Finally, on March 2010, a third new magnetar was discovered with Swift, SGR J1833-0832. I report below on the current status of the field and on several results combining multi-satellite and ground-based data

  2. GBM heterogeneity characterization by radiomic analysis of phenotype anatomical planes

    Science.gov (United States)

    Chaddad, Ahmad; Desrosiers, Christian; Toews, Matthew

    2016-03-01

    Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system, characterized among other traits by rapid metastatis. Three tissue phenotypes closely associated with GBMs, namely, necrosis (N), contrast enhancement (CE), and edema/invasion (E), exhibit characteristic patterns of texture heterogeneity in magnetic resonance images (MRI). In this study, we propose a novel model to characterize GBM tissue phenotypes using gray level co-occurrence matrices (GLCM) in three anatomical planes. The GLCM encodes local image patches in terms of informative, orientation-invariant texture descriptors, which are used here to sub-classify GBM tissue phenotypes. Experiments demonstrate the model on MRI data of 41 GBM patients, obtained from the cancer genome atlas (TCGA). Intensity-based automatic image registration is applied to align corresponding pairs of fixed T1˗weighted (T1˗WI) post-contrast and fluid attenuated inversion recovery (FLAIR) images. GBM tissue regions are then segmented using the 3D Slicer tool. Texture features are computed from 12 quantifier functions operating on GLCM descriptors, that are generated from MRI intensities within segmented GBM tissue regions. Various classifier models are used to evaluate the effectiveness of texture features for discriminating between GBM phenotypes. Results based on T1-WI scans showed a phenotype classification accuracy of over 88.14%, a sensitivity of 85.37% and a specificity of 96.1%, using the linear discriminant analysis (LDA) classifier. This model has the potential to provide important characteristics of tumors, which can be used for the sub-classification of GBM phenotypes.

  3. Role of avastin on the incidence of post-operative vitreous hemorrhage after vitrectomy in diabetic vitreous hemorrhage

    International Nuclear Information System (INIS)

    Diabetic retinopathy is one of the most common cause of legal blindness. Five to 10% of diabetic patients suffer from the proliferative diabetic retinopathy which includes the formation of new vessels on the retina and optic disc which can be complicated as vitreous hemorrhage and tractional retinal detachment. Pars plana vitrectomy along with laser photocoagulation is being used for the management of vitreous hemorrhage. In our study we used injection avastin one week before surgery to see its role on the incidence of rebleed after vitrectomy in diabetic vitreous hemorrhage. Materials and Methods; Fifty patients were divided into 2 equal groups on the basis of simple random sampling. 25 patients in Group I were operated with routine pars plana vitrectomy with endolaser photo- coagulation while in Group II all the 25 patients were given injection avastin intra-vitreally one week before surgery. Evaluation was done on the first post operative day, first follow up visit (one week) and after one month to see the incidence of re-bleed. Chi-square test was used for statistical analysis. Results: Fifty patients divided into two groups. In Group I, 3 patients had recurrent vitreous hemorrhage on first post-operative day, 3 patients had re-bleed on first follow up visit, and only 2 patients had re-bleed after one month. In Group II, none of the patients had recurrent vitreous hemorrhage on first post-operative day and on first follow-up visit (one week) while 2 patients had re-bleed after one month. Conclusion: Injection intravitreal Avastin (Bevaci- zumab) one week before surgery significantly reduces the risk of vitreous hemorrhage after vitrectomy in diabetic patients. (author)

  4. Intravitreal bevacizumab (Avastin treatment of diffuse diabetic macular edema in an Indian population

    Directory of Open Access Journals (Sweden)

    Kumar Atul

    2007-01-01

    Full Text Available Background: To report the anatomic and visual acuity response after intravitreal bevacizumab (Avastin in patients with diffuse diabetic macular edema. Design: Prospective, interventional case series study. Materials and Methods: This study included 20 eyes of metabolically stable diabetes mellitus with diffuse diabetic macular edema with a mean age of 59 years who were treated with two intravitreal injections of bevacizumab 1.25 mg in 0.05 ml six weeks apart. Main outcome measures were 1 early treatment diabetic retinopathy study visual acuity, 2 central macular thickness by optical coherence tomography imaging. Each was evaluated at baseline and follow-up visits. Results: All the eyes had received some form of laser photocoagulation before (not less than six months ago, but all of these patients had persistent diffuse macular edema with no improvement in visual acuity. All the patients received two injections of bevacizumab at an interval of six weeks per eye. No adverse events were observed, including endophthalmitis, inflammation and increased intraocular pressure or thromboembolic events in any patient. The mean baseline acuity was 20/494 (log Mar=1.338±0.455 and the mean acuity at three months following the second intravitreal injection was 20/295 (log Mar=1.094±0.254, a difference that was highly significant ( P =0.008. The mean central macular thickness at baseline was 492 µm which decreased to 369 µm ( P =0.001 at the end of six months. Conclusions: Initial treatment results of patients with diffuse diabetic macular edema not responding to previous photocoagulation did not reveal any short-term safety concerns. Intravitreal bevacizumab resulted in a significant decrease in macular thickness and improvement in visual acuity at three months but the effect was somewhat blunted, though still statistically significant at the end of six months.

  5. The Five Year Fermi/GBM Magnetar Burst Catalog

    Science.gov (United States)

    Collazzi, A. C.; Kouveliotou, C.; van der Horst, A. J.; Younes, G. A.; Kaneko, Y.; Göğüş, E.; Lin, L.; Granot, J.; Finger, M. H.; Chaplin, V. L.; Huppenkothen, D.; Watts, A. L.; von Kienlin, A.; Baring, M. G.; Gruber, D.; Bhat, P. N.; Gibby, M. H.; Gehrels, N.; McEnery, J.; van der Klis, M.; Wijers, R. A. M. J.

    2015-05-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  6. The Five Year Fermi/GBM Magnetar Burst Catalog

    CERN Document Server

    Collazzi, A C; van der Horst, A J; Younes, G A; Kaneko, Y; Gogus, E; Lin, L; Granot, J; Finger, M H; Chaplin, V L; Huppenkothen, D; Watts, A L; von Kienlin, A; Baring, M G; Gruber, D; Bhat, P N; Gibby, M H; Gehrels, N; McEnery, J; van der Klis, M; Wijers, R A M J

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here we present the Fermi/GBM magnetar catalog, giving the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from July 2008 to June 2013. We provide durations, spectral parameters for various models, fluences and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  7. THE FIVE YEAR FERMI/GBM MAGNETAR BURST CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Collazzi, A. C. [SciTec, Inc., 100 Wall Street, Princeton, NJ 08540 (United States); Kouveliotou, C.; Horst, A. J. van der; Younes, G. A. [Department of Physics, The George Washington University, 725 21st Street NW, Washington, DC 20052 (United States); Kaneko, Y.; Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); Lin, L. [François Arago Centre, APC, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris (France); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Raanana 43537 (Israel); Finger, M. H. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Chaplin, V. L. [School of Medicine, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 (United States); Huppenkothen, D. [Center for Data Science, New York University, 726 Broadway, 7th Floor, New York, NY 10003 (United States); Watts, A. L. [Anton Pannekoek Institute, University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Kienlin, A. von [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H., E-mail: acollazzi@scitec.com [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2015-05-15

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550–5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  8. The Five Year Fermi/GBM Magnetar Burst Catalog

    NARCIS (Netherlands)

    A.C. Collazzi; C. Kouveliotou; A.J. van der Horst; G.A. Younes; Y. Kaneko; E. Göğüş; L. Lin; J. Granot; M.H. Finger; V.L. Chaplin; D. Huppenkothen; A.L. Watts; A. von Kienlin; M.G. Baring; D. Gruber; P.N. Bhat; M.H. Gibby; N. Gehrels; J. Mcenery; M. van der Klis; R.A.M.J. Wijers

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present

  9. Fermi GBM Observations of LIGO Gravitational Wave event GW150914

    CERN Document Server

    Connaughton, V; Goldstein, A; Briggs, M S; Zhang, B -B; Hui, C M; Jenke, P; Racusin, J; Wilson-Hodge, C A; Bhat, P N; Cleveland, W; Fitzpatrick, G; Giles, M M; Gibby, M H; Greiner, J; von Kienlin, A; Kippen, R M; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O; Sparke, L; Stanbro, M; Toelge, K; Veres, P; Yu, H -F; authors, other

    2016-01-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO)event GW150914 reveal the presence of a weak transient source above 50 keV, 0.4 s after the GW event was detected, with a false alarm probability of 0.0022. This weak transient lasting 1 s does not appear connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event suggest it is a weak short Gamma-Ray Burst arriving at a large angle to the direction in which Fermi was pointing, where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, this electromagnetic signal from a stellar mass black hole binary merger is unexpected....

  10. High-energy transients with Fermi/GBM

    International Nuclear Information System (INIS)

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These γ-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of γ-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in γ-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (Epeak) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility. Finally, I present the results of the search for untriggered GRBs in GBM data. This

  11. Violation of Einstein's Equivalence Principle on Gravitational Wave Event GW150914 Associated with GBM Transient GW150914-GBM

    CERN Document Server

    Liu, Molin; You, Xiaohe; Lu, Jianbo; Xu, Lixin

    2016-01-01

    In this paper, we test Einstein's equivalence principle (EEP) about gravitational wave transient GW150914 associated with weak electromagnetic signal GW150914-GBM observed by Gamma-ray Burst Monitor (GBM). We study the differences of parametrized post Newtonian (PPN) parameter $\\gamma$ between different particles in LIGO and GBM including the initial outburst gravitons and photons, the gravitons with frequency from 35 to 250 Hz and the photons in hard X-ray emission between 1 KeV and 10 MeV. The calculations are performed on the possible localizations of GW150914 which contains a best fit localization with $68\\%$ statistical uncertainty region over 9000 square degrees and the 11 sky locations with $5^{\\circ}$ apart on LIGO localization arc being visible to GBM. The results show that the violation of EEP, at least on the order of magnitude, is quite insensitive to the location of source. The initial outburst gravitons give us a very tight constrain on the violation of EEP and the accuracy is up to at least $10...

  12. Recruitment of bone marrow derived cells during anti-angiogenic therapy in GBM : Bone marrow derived cell in GBM

    NARCIS (Netherlands)

    Boer, Jennifer C.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Glioblastoma (GBM) is a highly vascular tumor characterized by rapid and invasive tumor growth, followed by oxygen depletion, hypoxia and neovascularization, which generate a network of disorganized, tortuous and permeable vessels. Recruitment of bone marrow derived cells (BMDC) is crucial for vascu

  13. Clinical and histological findings after intravitreal injection of bevacizumab (Avastin) in a porcine model of choroidal neovascularization

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik;

    2010-01-01

    was identified immunohistochemically in the inner limiting membrane (ILM) and to a lesser degree in the remaining retina. Strong staining was also detected in both retinal blood vessels and entire CNV membranes with no cellular predisposition. Vascular endothelial growth factor expression was found in the CNV...... membranes, in the ILM, in the ganglion cell layer, in Müller cells throughout the neuroretina and in retinal blood vessels. CONCLUSIONS: Bevacizumab significantly reduced the proliferation of vascular endothelial cells in CNV membranes and showed a strong trend towards a reduction of leakage from......PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes...

  14. Clinical and histological findings after intravitreal injection of bevacizumsb (Avastin®) in a porcine model of choroidal neovascularisation

    DEFF Research Database (Denmark)

    Lassota, Nathan; Prause, Jan Ulrik; Scherfig, Erik;

    2010-01-01

    was identified immunohistochemically in the inner limiting membrane (ILM) and to a lesser degree in the remaining retina. Strong staining was also detected in both retinal blood vessels and entire CNV membranes with no cellular predisposition. Vascular endothelial growth factor expression was found in the CNV...... membranes, in the ILM, in the ganglion cell layer, in Müller cells throughout the neuroretina and in retinal blood vessels. CONCLUSIONS: Bevacizumab significantly reduced the proliferation of vascular endothelial cells in CNV membranes and showed a strong trend towards a reduction of leakage from......PURPOSE: To examine the effect of intravitreally injected bevacizumab (Avastin) on the histological and angiographic morphology of choroidal neovascularization (CNV) in a masked and placebo-controlled animal study. METHODS: Choroidal neovascularization was induced surgically in 11 porcine eyes...

  15. High-energy transients with Fermi/GBM

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, David

    2012-10-09

    For most of mankind's history, astronomy was performed on-ground in the optical energy range. It was only when space-based missions, built more than 50 years ago, detected photons with mind-boggling energies that the exploration of the violent Universe really began. These {gamma}-ray photons still provide us with an unprecedented wealth of information for the most energetic processes taking place in the cosmos. Faithful to the olympic slogan ''higher, faster, further'', an increasing armada of {gamma}-ray satellites was built and launched over the last couple of decades with Fermi being the youngest of its kind. In this thesis, I use data from the Gamma-Ray Burst Monitor (GBM) onboard the Fermi satellite. The focus of this work lies on three very different classes of high-energy astrophysical transients: Gamma-Ray Bursts (GRBs), solar flares and Soft Gamma Repeaters (SGRs). In Chapter 2, I present GRB 091024A, a burst of very long duration in {gamma}-rays where optical data could be acquired well during its active phase. The optical light curve shows very intriguing features which I subsequently interpret as the so called ''optical flash'', a fundamental property of the ''fireball'' model. Although predicted by the latter model, only a handful of GRBs show such a behavior, making them interesting transients to study. Furthermore, I present the fundamental temporal and spectral properties of 47 GBM-detected GRBs with known redshifts. As GRBs explode at cosmological distances it is of uttermost importance to study them in their restframe to get a better understanding of their emission mechanisms. I confirm several correlations already found in the past together with an intriguing connection between redshift and the peak energy (E{sub peak}) of GRBs. Although this correlation is heavily influenced by instrumental effects, it is not unexpected from other experimental results, giving it more credibility

  16. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    Science.gov (United States)

    Hurley, K.; Briggs, M.; Connaughton, V.; Meegan, C.; von Kienlin, A.; Rau, A.; Zhang, X.; Golenetskii, S.; Aptekar, R.; Mazets, E.; Pal'shin, V.; Fredericks, D.; Barthelmy, S.; Cummings, J.; Gehrels, N.; Krimm, H. A.; Mitrofanov, I. G.; Golovin, D.; Litvak, M. L.; Sanin, A. B.; Boynton, W.; Fellows, C.; Harshman, K.; Starr, R.; Goldsten, J.

    2012-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  17. The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

    CERN Document Server

    Hurley, K; Connaughton, V; Meegan, C; von Kienlin, A; Rau, A; Zhang, X; Golenetskii, S; Aptekar, R; Mazets, E; Pal'shin, V; Frederiks, D; Barthelmy, S; Cline, T; Cummings, J; Gehrels, N; Krimm, H A; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Starr, R; Smith, D M; Hajdas, W; Yamaoka, K; Ohno, M; Fukazawa, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Palmer, D M; Goldsten, J; Del Monte, E; Feroci, M; Marisaldi, M

    2011-01-01

    In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations.

  18. THE FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Paciesas, William S.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam; Guiriec, Sylvain [Center for Space Plasma and Aeronomic Research, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Meegan, Charles A.; Van der Horst, Alexander J. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Von Kienlin, Andreas; Diehl, Roland; Foley, Suzanne; Greiner, Jochen; Gruber, David [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Bissaldi, Elisabetta [Institute of Astro and Particle Physics, University Innsbruck, Technikerstrasse 25, 6176 Innsbruck (Austria); Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., 1525 Perimeter Pkwy NW, Huntsville, AL 35806 (United States); and others

    2012-03-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  19. The Search for Type 1 X-ray Bursts with Fermi/GBM

    Science.gov (United States)

    Jenke, Peter; Linares, M.; Connaughton, V.; Camero-Arranz, A.; Finger, M. H.; WIlson-Hodge, C. A.; Van Der Horst, A.; Fermi GBM X-ray Burst Collaboration

    2012-01-01

    We discuss the first results of the Fermi-GBM all-sky search for X-ray bursts. The very large field of view and X-ray response of the Fermi-GBM make it a unique instrument to study rare, bright and short-lived X-ray bursts. We are performing a systematic search that exploits such capabilities. We present results on long/intermediate type I X-ray bursts, an unusual kind of thermonuclear bursts from accreting neutron stars, and show how Fermi-GBM is giving, for the first time, robust measurements of their recurrence time.

  20. The Fermi GBM Gamma-Ray Burst Catalog: The First Two Years

    CERN Document Server

    Paciesas, William S; von Kienlin, Andreas; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Chaplin, Vandiver; Connaughton, Valerie; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kippen, R Marc; Kouveliotou, Chryssa; Lichti, Giselher; Lin, Lin; McBreen, Sheila; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen

    2012-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) is designed to enhance the scientific return from Fermi in studying gamma-ray bursts (GRBs). In its first two years of operation GBM triggered on 491 GRBs. We summarize the criteria used for triggering and quantify the general characteristics of the triggered GRBs, including their locations, durations, peak flux, and fluence. This catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  1. Fermi/GBM Observations of SGR J0501+4516

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; van der Horst, Alexander J.

    2011-08-01

    The magnetar candidate SGR J0501+4516 was discovered when it became active for about 13 days from August 22 to September 3, 2008. During this period, the Gamma-ray Burst Monitor (GBM) onboard Fermi detected over 30 bursts. We present here our results on the temporal and spectral analysis of the 29 bursts for which high spectral and time resolution data is available. We find that the T90 durations of the bursts follow a log-normal distribution with a mean value of ~123 ms. We fit the time-integrated spectrum of each burst with several models: a black body function, optically thin thermal brehmsstrahlung, a power law with an exponential cut-off, two black body functions, and the combination of a black body and a power law. We discuss our results in the context of the spectral properties of other magnetar bursts and we also present some correlations between the spectral parameters of the best fit models for all bursts. Finally, we present the results of our time-resolved spectral analysis of the five brightest bursts and discuss how they compare with our time-integrated results.

  2. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells

    Directory of Open Access Journals (Sweden)

    Tzuu-Yuan Huang

    2012-01-01

    Full Text Available Demethoxycurcumin (DMC; a curcumin-related demethoxy compound has been recently shown to display antioxidant and antitumor activities. It has also produced a potent chemopreventive action against cancer. In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells. We have studied the mitochondrial membrane potential (MMP, DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity. By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells. Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.

  3. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM

    OpenAIRE

    Srinivasan, Radhika; Phillips, Joanna J.; Vandenberg, Scott R.; Polley, Mei-Yin C.; Bourne, Gabriela; Au, Alvin; Pirzkall, Andrea; Cha, Soonmee; Chang, Susan M.; Nelson, Sarah J.

    2010-01-01

    The motivation of this study was to address the urgent clinical problem related to the inability of magnetic resonance (MR) imaging measures to differentiate tumor progression from treatment effects in patients with glioblastoma multiforme (GBM). While contrast enhancement on MR imaging (MRI) is routinely used for assessment of tumor burden, therapy response, and progression-free survival in GBM, it is well known that changes in enhancement following treatment are nonspecific to tumor. To add...

  4. On the GBM event seen 0.4 sec after GW 150914

    CERN Document Server

    Greiner, J; Savchenko, V; Yu, H -F

    2016-01-01

    In view of the recent report by Connaughton [arXiv:1602.03920.v3] we analyse continuous TTE data of Fermi-GBM around the time of the gravitational wave event GW 150914. We find that after proper accounting for low count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM-ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broad-band light curve even smaller than that of the GBM-GW150914 event are recovered as proper non-zero source, while the GBM-GW150914 event is consistent with zero fluence.

  5. Is the GW150914-GBM really associated with the GW150914?

    CERN Document Server

    Xiong, Shaolin

    2016-01-01

    Finding the electromagnetic (EM) counterpart is critically important for a gravitational wave event. Although many efforts have been made to search for the purported EM counterpart of GW150914, the first gravitational wave event detected by LIGO, only Fermi/GBM reported an excess above background (i.e. GW150914-GBM) at 0.4 s after the LIGO trigger time, that is possibly associated with this GW event (Connaughton et al. 2016). However, since there is no significant detection by the INTEGRAL/SPI-ACS around the time of GW150914-GBM, a great debate has been raised about whether GW150914-GBM is of astrophysical origin and associated with the GW150914 (Savchenko et al. 2016). In order to answer this question, we re-analyzed the GBM data with a straightforward but sophisticated method. We find that the excess of GW150914-GBM mostly comes from those detectors with bad viewing angles to the GW event, whereas the good viewing detectors see nothing significant beyond background fluctuation around the trigger time of GW1...

  6. Bevacizumab (Avastin®) no tratamento da membrana neovascular coroidal secundária à degeneração macular relacionada à idade: relato de caso Bevacizumab (Avastin®) in treatment of choroidal neovascularization secondary to age-related macular degeneration: a case report

    OpenAIRE

    Tiago Eugênio Faria e Arantes; Vinícius Paganini Nascimento; Otacílio de Oliveira Maia Júnior; Walter Yukihiko Takahashi

    2007-01-01

    As drogas anti-angiogênicas foram introduzidas recentemente no arsenal terapêutico das membranas neovasculares coroidais. O objetivo deste relato é descrever um caso de membranas neovasculares coroidais oculta com extenso descolamento do epitélio pigmentado da retina, tratada com bevacizumab (Avastin®) intravítrea. A eficácia da medicação foi avaliada por meio da acuidade visual e de exames complementares (angiografia fluoresceínica, videoangiografia com indocianina verde e tomografia de coer...

  7. Paradox of Migration in Kolkata: A Megacity in GBM Delta

    Science.gov (United States)

    Das, S.; Hazra, S.; Ghosh, T.

    2015-12-01

    Contrary to other coastal cities (Mumbai, Chennai, Bhubaneswar etc.) in India, Kolkata, the largest city of India until 1990, has been showing a persistent trend of out-migration over the last decade. The situation is more paradoxical when compared to Dhaka in Bangladesh, the other coastal city in Ganga-Brahmaputra-Meghna (GBM) delta. Exacerbating impacts of Climate Change like accelerated sea level rise, impact of cyclones, rising temperature and high rainfall events and waterlogging, vis-à-vis the density of poor population in slums, Kolkata has been assessed as one of the most vulnerable cities of the world. However, Kolkata has long been a preferred destination for migrants for its port based economy, existence of industrial belt with labour intensive industries. The city and its surrounding districts attracted a massive influx of trans-border migrants when India and Bangladesh gained Independence in 1947 and 1971 respectively. The paper attempts to explore reasons behind the present trend of depopulation in the erstwhile preferred migration destination. This paper distinguishes between 'Kolkata City' (census district) with 4.5 million residents and 'Kolkata Megacity' which encompasses also the peri-urban areas and home to almost 14.1 million people according to Census 2011. Analysing migration as an ongoing research activity under DECCMA project, an overall 'in-migration' pattern can be deciphered in Kolkata 'megacity'. On the contrary, the Kolkata 'city' located right in the heart of the megacity exhibits negative net migration (-5.11%) i.e. high 'out-migration'. Plausible causes can be movement of people from Kolkata 'city' to peri-urban areas and satellite towns (urban to urban migration) probably due to closure of labour intensive industries, comparatively lower land prices, availability of space and accommodation, lower costs of living, development of different modes of commutation and communication. Further growth of population in the Kolkata Megacity

  8. Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines.

    Science.gov (United States)

    Tezcan, Gulcin; Tunca, Berrin; Bekar, Ahmet; Yalcin, Murat; Sahin, Saliha; Budak, Ferah; Cecener, Gulsah; Egeli, Unal; Demir, Cevdet; Guvenc, Gokcen; Yilmaz, Gozde; Erkan, Leman Gizem; Malyer, Hulusi; Taskapilioglu, Mevlut Ozgur; Evrensel, Turkkan; Bilir, Ayhan

    2015-03-01

    Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients is required. Induction of tumor cell death by certain phytochemicals derived from medicinal herbs and dietary plants has become a new frontier for cancer therapy research. Although the cancer suppressive effect of Ficus carica (fig) latex (FCL) has been determined in a few cancer types, the effect of this latex on GBM tumors has not been investigated. Therefore, in the current study, the anti-proliferative activity of FCL and the effect of the FCL-temozolomide (TMZ) combination were tested in the T98G, U-138 MG, and U-87 MG GBM cell lines using the WST-1 assay. The mechanism of cell death was analyzed using Annexin-V/FITC and TUNEL assays, and the effect of FCL on invasion was tested using the chick chorioallantoic membrane assay. To determine the effect of FCL on GBM progression, the expression levels of 40 GBM associated miRNAs were analyzed in T98G cells using RT-qPCR. According to the obtained data, FCL causes cell death in GBM cells with different responses to TMZ, and this effect is synergistically increased in combination with TMZ. In addition, the current study is the first to demonstrate the effect of FCL on modulation of let-7d expression, which may be an important underlying mechanism of the anti-invasive effect of this extract. PMID:25212824

  9. RM-06IN VITRO CLONAL EVOLUTION OF GLIOBLASTOMA (GBM) BRAIN TUMOUR INITIATING CELLS (BTIC) TO MODEL TUMOUR RECURRENCE

    OpenAIRE

    Qazi, Maleeha; Vora, Parvez; Venugopal, Chitra; McFarlane, Nicole; Hallett, Robin; Singh, Sheila

    2014-01-01

    Glioblastoma (GBM) is the most common and highly aggressive primary adult brain tumour. Despite multimodal therapy, patients on average experience relapse at 9 months and median survival rarely extends beyond 15 months. Targeting the cells that drive GBM formation as well as its inevitable and rapid recurrence has remained a major challenge, likely due to intra-tumoral heterogeneity. At the genetic level, this heterogeneity has prompted a molecular classification of GBM based on differential ...

  10. The 3rd Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    CERN Document Server

    Bhat, P Narayana; von Kienlin, Andreas; Paciesas, William S; Briggs, Michael S; Burgess, J Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H; Collazzi, Andrew C; Connaughto, Valerie; Diekmann, Anne M; Fitzpatrick, Gerard; Gibby, Melissa H; Giles, Misty M; Goldstein, Adam M; Greiner, Jochen; Jenke, Peter A; Kippen, R Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D; Roberts, Oliver J; Sparke, Linda S; Stanbro, Matthew; Veres, Peter; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-01-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two gamma-ray bursts (GRB) every three days. Here we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years, through the middle of July 2014. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300~keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBM's low-energy NaI(Tl) detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRB...

  11. THE SECOND FERMI GBM GAMMA-RAY BURST CATALOG: THE FIRST FOUR YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Von Kienlin, Andreas; Greiner, Jochen; Gruber, David [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Meegan, Charles A.; Bhat, P. N.; Briggs, Michael S.; Burgess, J. Michael; Chaplin, Vandiver; Connaughton, Valerie; Goldstein, Adam [University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Paciesas, William S.; Cleveland, William [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Bissaldi, Elisabetta [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Byrne, David; Fitzpatrick, Gerard; Foley, Suzanne [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Collazzi, Andrew C. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Gibby, Melissa; Giles, Misty [Jacobs Technology, Inc., Huntsville, AL 35806 (United States); Guiriec, Sylvain [NASA-Goddard Space Flight Center, Greenbelt, MD 20771 (United States); and others

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  12. The 2nd Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    CERN Document Server

    von Kienlin, Andreas; Paciesas, William S; Bhat, P N; Bissaldi, Elisabetta; Briggs, Michael S; Burgess, J Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinead; Pelassa, Veronique; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-01-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50 - 300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10 - 1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM sci...

  13. The Second Fermi GBM Gamma-Ray Burst Catalog: The First Four Years

    Science.gov (United States)

    von Kienlin, Andreas; Meegan, Charles A.; Paciesas, William S.; Bhat, P. N.; Bissaldi, Elisabetta; Briggs, Michael S.; Burgess, J. Michael; Byrne, David; Chaplin, Vandiver; Cleveland, William; Connaughton, Valerie; Collazzi, Andrew C.; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Greiner, Jochen; Gruber, David; Guiriec, Sylvain; van der Horst, Alexander J.; Kouveliotou, Chryssa; Layden, Emily; McBreen, Sheila; McGlynn, Sinéad; Pelassa, Veronique; Preece, Robert D.; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung

    2014-03-01

    This is the second of a series of catalogs of gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM). It extends the first two-year catalog by two more years, resulting in an overall list of 953 GBM triggered GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM detected GRBs. For each GRB the location and main characteristics of the prompt emission, the duration, peak flux and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band, where the maximum energy release of GRBs in the instrument reference system is observed and also for a broader energy band from 10-1000 keV, exploiting the full energy range of GBMs low-energy detectors. Furthermore, information is given on the settings and modifications of the triggering criteria and exceptional operational conditions during years three and four in the mission. This second catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  14. An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy

    Directory of Open Access Journals (Sweden)

    Vinay Minocha

    2014-01-01

    Full Text Available Introduction. The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN; however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency. We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM antibody. Case Presentation. We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis. Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units. A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. Conclusion. This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy. More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.

  15. Implication of the association between GBM transient 150914 and LIGO Gravitational Wave event GW150914

    CERN Document Server

    Li, Xiang; Yuan, Qiang; Jin, Zhi-Ping; Fan, Yi-Zhong; Liu, Si-Ming; Wei, Da-Ming

    2016-01-01

    On September 14, 2015 the two detectors of LIGO simultaneously detected a transient gravitational-wave signal GW150914 and the Fermi GBM observations found a weak short gamma-ray burst (SGRB)-like transient (i.e., the GBM transient 150914). The time and location coincidences favor the association between GW150904 and GBM transient 150914. We compared GBM transient 150914 with other SGRBs and found that such an event is indeed a distinct outlier in the $E_{\\rm p,rest}-E_{\\rm iso}$ and $E_{\\rm p,rest}-L_{\\gamma}$ diagrams ($E_{\\rm iso}$ is the isotropic-equivalent energy, $L_\\gamma$ is the luminosity and $E_{\\rm p,rest}$ is the rest frame peak energy of the prompt emission), possibly due to its specific binary-black-hole merger origin. However, the presence of a "new" group of SGRBs with "low" $L_\\gamma$ and $E_{\\rm iso}$ but high $E_{\\rm p,rest}$ is also possible. If the outflow of GBM transient 150914 was launched by the accretion onto the nascent black hole, we estimate the accretion disk mass to be $\\sim 10...

  16. Bevacizumab (Avastin® no tratamento da membrana neovascular coroidal secundária à degeneração macular relacionada à idade: relato de caso Bevacizumab (Avastin® in treatment of choroidal neovascularization secondary to age-related macular degeneration: a case report

    Directory of Open Access Journals (Sweden)

    Tiago Eugênio Faria e Arantes

    2007-12-01

    Full Text Available As drogas anti-angiogênicas foram introduzidas recentemente no arsenal terapêutico das membranas neovasculares coroidais. O objetivo deste relato é descrever um caso de membranas neovasculares coroidais oculta com extenso descolamento do epitélio pigmentado da retina, tratada com bevacizumab (Avastin® intravítrea. A eficácia da medicação foi avaliada por meio da acuidade visual e de exames complementares (angiografia fluoresceínica, videoangiografia com indocianina verde e tomografia de coerência óptica. Após três injeções intravítreas de bevacizumab, obteve-se uma resposta anatômica e visual satisfatória, denotando benefícios da droga, apesar do extenso descolamento do epitélio pigmentado da retina associada a membranas neovasculares coroidais oculta.The antiangiogenic drugs have been recently introduced in the therapeutic armamentarium of choroidal neovascularization. The purpose of this report is to describe a case of occult choroidal neovascularization with extensive retinal pigment epithelial detachment treated with intravitreal bevacizumab (Avastin®. The efficacy of the medication was evaluated by means of visual acuity and complementary exams (fluorescein angiography, indocyanine green video angiography and optical coherence tomography. After three intravitreal injections of bevacizumab a satisfactory anatomic and visual response was achieved, showing benefits of the drug, despite the extensive retinal pigment epithelial detachment associated with occult choroidal neovascularization.

  17. Monitoring the Low-Energy Gamma-Ray Sky Using Earth Occultation with GLAST GBM

    International Nuclear Information System (INIS)

    Long term all-sky monitoring of the 20 keV - 2 MeV gamma-ray sky using the Earth occultation technique was demonstrated by the BATSE instrument on the Compton Gamma Ray Observatory. The principles and techniques used for the development of an end-to-end earth occultation data analysis system for BATSE can be extended to the GLAST Burst Monitor (GBM), resulting in multiband light curves and time-resolved spectra in the energy range 8 keV to above 1 MeV for known gamma-ray sources and transient outbursts, as well as the discovery of new sources of gamma-ray emission. In this paper we describe the application of the technique to the GBM. We also present the expected sensitivity for the GBM

  18. Earth Occultation Monitoring of the Hard X-ray/Low-Energy Gamma Ray Sky with GBM

    Science.gov (United States)

    Cherry, Michael L.; Camero-Arranz, A.; Case, G. L.; Chaplin, V.; Finger, M. H.; Jenke, P. A.; Rodi, J. C.; Wilson-Hodge, C. A.; GBM Earth Occultation Team

    2012-01-01

    By utilizing the Earth occultation technique (EOT), the Gamma-Ray Burst Monitor (GBM) instrument aboard Fermi has been used to make nearly continuous full-sky observations in the 8-1000 keV energy range. The GBM EOT analysis program currently monitors an input catalog containing 235 sources. We will present the GBM catalog of sources observed in the first 3 years of the EOT monitoring program, with special emphasis on the high energy (>100 keV) and time-variable sources, in particular the Crab, Cyg X-1, and A0535+26. We will also describe the initial results of an all-sky imaging analysis of the EOT data, with comparisons to the Swift, INTEGRAL, and Fermi LAT catalogs. This work is supported by the NASA Fermi Guest Investigator program, NASA/Louisiana Board of Regents, and Spanish Ministerio de Ciencia de Innovacion.

  19. The First Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Briggs, Michael; Connaughton, Valerie; Stanbro, Matthew; Zhang, Binbin; Bhat, Narayana; Fishman, Gerald; Roberts, Oliver; Fitzpatrick, Gerard; McBreen, Shelia; Grove, Eric; Chekhtman, Alexandre

    2015-04-01

    We present summary results from the first catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Space Telescope. The catalog reports parameters for over 2700 TGFs. Since the launch of Fermi in 2008 the TGF detection sensitivity of GBM has been improved several times, both in the flight software and in ground analysis. Starting in 2010 July individual photons were downloaded for portions of the orbits, enabling an off-line search that found weaker and shorter TGFs. Since 2012 November 26 this telemetry mode has been extended to continuous coverage. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs).

  20. The Fermi-GBM 3-year X-ray Burst Catalog

    CERN Document Server

    Jenke, P A; Connaughton, V; Beklen, E; Camero-Arranz, A; Finger, M H; Wilson-Hodge, C A

    2016-01-01

    The Fermi Gamma Ray Burst Monitor (GBM) is an all sky gamma-ray monitor well known in the gamma-ray burst community. Although GBM excels in detecting the hard, bright extragalactic GRBs, its sensitivity above 8 keV and all-sky view make it an excellent instrument for the detection of rare, short-lived Galactic transients. In March 2010, we initiated a systematic search for transients using GBM data. We conclude this phase of the search by presenting a 3 year catalog of 1084 non-solar events. Using spectral analysis, location and spatial distributions we subdivided the 1084 events into 752 thermonuclear X-ray bursts, 267 transient events from accretion flares and X-ray pulses, and 65 untriggered gamma-ray bursts.

  1. The Third Fermi GBM Gamma-Ray Burst Catalog: The First Six Years

    Science.gov (United States)

    Narayana Bhat, P.; Meegan, Charles A.; von Kienlin, Andreas; Paciesas, William S.; Briggs, Michael S.; Burgess, J. Michael; Burns, Eric; Chaplin, Vandiver; Cleveland, William H.; Collazzi, Andrew C.; Connaughton, Valerie; Diekmann, Anne M.; Fitzpatrick, Gerard; Gibby, Melissa H.; Giles, Misty M.; Goldstein, Adam M.; Greiner, Jochen; Jenke, Peter A.; Kippen, R. Marc; Kouveliotou, Chryssa; Mailyan, Bagrat; McBreen, Sheila; Pelassa, Veronique; Preece, Robert D.; Roberts, Oliver J.; Sparke, Linda S.; Stanbro, Matthew; Veres, Péter; Wilson-Hodge, Colleen A.; Xiong, Shaolin; Younes, George; Yu, Hoi-Fung; Zhang, Binbin

    2016-04-01

    Since its launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has triggered and located on average approximately two γ-ray bursts (GRBs) every three days. Here, we present the third of a series of catalogs of GRBs detected by GBM, extending the second catalog by two more years through the middle of 2014 July. The resulting list includes 1405 triggers identified as GRBs. The intention of the GBM GRB catalog is to provide information to the community on the most important observables of the GBM-detected GRBs. For each GRB, the location and main characteristics of the prompt emission, the duration, peak flux, and fluence are derived. The latter two quantities are calculated for the 50-300 keV energy band where the maximum energy release of GRBs in the instrument reference system is observed, and also for a broader energy band from 10 to 1000 keV, exploiting the full energy range of GBM's low-energy [Nai[Tl)] detectors. Using statistical methods to assess clustering, we find that the hardness and duration of GRBs are better fit by a two-component model with short-hard and long-soft bursts than by a model with three components. Furthermore, information is provided on the settings and modifications of the triggering criteria and exceptional operational conditions during years five and six in the mission. This third catalog is an official product of the Fermi GBM science team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  2. VizieR Online Data Catalog: Localizations of GRBs with Fermi GBM (Connaughton+, 2015)

    Science.gov (United States)

    Connaughton, V.; Briggs, M. S.; Goldstein, A.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Wilson-Hodge, C. A.; Gibby, M. H.; Greiner, J.; Gruber, D.; Jenke, P.; Kippen, R. M.; Pelassa, V.; Xiong, S.; Yu, H.-F.; Bhat, P. N.; Burgess, J. M.; Byrne, D.; Fitzpatrick, G.; Foley, S.; Giles, M. M.; Guiriec, S.; van der Horst, A. J.; von Kienlin, A.; McBreen, S.; McGlynn, S.; Tierney, D.; Zhang, B.-B.

    2015-03-01

    Between 2008 July and 2013 May, GBM triggered on 203 GRBs that were well-localized by other instruments or by the IPN, with location uncertainties (68% confidence level) smaller than 1°. These 203 reference locations are listed in Table 9. (2 data files).

  3. Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

    CERN Document Server

    Rodi, J; Case, G L; Camero-Arranz, A; Chaplin, C; Finger, M H; Jenke, P; Wilson-Hodge, C A

    2013-01-01

    The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. Imaging with a Differential filter using the Earth Occultation Method (IDEOM) has been developed to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT. IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky images have been generated for ~4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. Analysis resulted in the detection of 43 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. IDEOM analysis has resulted in the addition of 16 sources to the GBM-EOT catalog. We also present the first joined averaged spectra fo...

  4. MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

    Science.gov (United States)

    Grossman, Rachel; Burger, Peter; Soudry, Ethan; Tyler, Betty; Chaichana, Kaisorn L; Weingart, Jon; Olivi, Alessandro; Gallia, Gary L; Sidransky, David; Quiñones-Hinojosa, Alfredo; Ye, Xiaobu; Brem, Henry

    2015-12-01

    We examined the relationship between the O(6)-methylguanine-methyltransferase (MGMT) methylation status and clinical outcomes in newly diagnosed glioblastoma multiforme (GBM) patients who were treated with Gliadel wafers (Eisai, Tokyo, Japan). MGMT promoter methylation has been associated with increased survival among patients with GBM who are treated with various alkylating agents. MGMT promoter methylation, in DNA from 122 of 160 newly diagnosed GBM patients treated with Gliadel, was determined by a quantitative methylation-specific polymerase chain reaction, and was correlated with overall survival (OS) and recurrence-free survival (RFS). The MGMT promoter was methylated in 40 (32.7%) of 122 patients. The median OS was 13.5 months (95% confidence interval [CI] 11.0-14.5) and RFS was 9.4 months (95% CI 7.8-10.2). After adjusting for age, Karnofsky performance score, extent of resection, temozolomide (TMZ) and radiation therapy (RT), the newly diagnosed GBM patients with MGMT methylation had a 15% reduced mortality risk, compared to patients with unmethylated MGMT (hazard ratio 0.85; 95% CI 0.56-1.31; p=0.46). The patients aged over 70 years with MGMT methylation had a significantly longer median OS of 13.5 months, compared to 7.6 months in patients with unmethylated MGMT (p=0.027). A significant difference was also found in older patients, with a median RFS of 13.1 versus 7.6 months for methylated and unmethylated MGMT groups, respectively (p=0.01). Methylation of the MGMT promoter in newly diagnosed GBM patients treated with Gliadel, RT and TMZ, was associated with significantly improved OS compared to the unmethylated population. In elderly patients, methylation of the MGMT promoter was associated with significantly better OS and RFS. PMID:26249244

  5. Fermi GBM Observations of LIGO Gravitational-wave Event GW150914

    Science.gov (United States)

    Connaughton, V.; Burns, E.; Goldstein, A.; Blackburn, L.; Briggs, M. S.; Zhang, B.-B.; Camp, J.; Christensen, N.; Hui, C. M.; Jenke, P.; Littenberg, T.; McEnery, J. E.; Racusin, J.; Shawhan, P.; Singer, L.; Veitch, J.; Wilson-Hodge, C. A.; Bhat, P. N.; Bissaldi, E.; Cleveland, W.; Fitzpatrick, G.; Giles, M. M.; Gibby, M. H.; von Kienlin, A.; Kippen, R. M.; McBreen, S.; Mailyan, B.; Meegan, C. A.; Paciesas, W. S.; Preece, R. D.; Roberts, O. J.; Sparke, L.; Stanbro, M.; Toelge, K.; Veres, P.

    2016-07-01

    With an instantaneous view of 70% of the sky, the Fermi Gamma-ray Burst Monitor (GBM) is an excellent partner in the search for electromagnetic counterparts to gravitational-wave (GW) events. GBM observations at the time of the Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914 reveal the presence of a weak transient above 50 keV, 0.4 s after the GW event, with a false-alarm probability of 0.0022 (2.9σ). This weak transient lasting 1 s was not detected by any other instrument and does not appear to be connected with other previously known astrophysical, solar, terrestrial, or magnetospheric activity. Its localization is ill-constrained but consistent with the direction of GW150914. The duration and spectrum of the transient event are consistent with a weak short gamma-ray burst (GRB) arriving at a large angle to the direction in which Fermi was pointing where the GBM detector response is not optimal. If the GBM transient is associated with GW150914, then this electromagnetic signal from a stellar mass black hole binary merger is unexpected. We calculate a luminosity in hard X-ray emission between 1 keV and 10 MeV of {1.8}-1.0+1.5× {10}49 erg s-1. Future joint observations of GW events by LIGO/Virgo and Fermi GBM could reveal whether the weak transient reported here is a plausible counterpart to GW150914 or a chance coincidence, and will further probe the connection between compact binary mergers and short GRBs.

  6. SU-C-BRE-03: Dual Compartment Mathematical Modeling of Glioblastoma Multiforme (GBM)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Kupelian, P; Kaprealian, T; Selch, M; Low, D; Pajonk, F; Sheng, K [UCLA, Los Angeles, CA (United States)

    2014-06-15

    Purpose: To explore the aggressive recurrence and radioresistence of GBM with a dual compartment tumor survival mathematical model based on intrinsic tumor heterogeneity, cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The repopulation and differentiation responses to radiotherapy of a solid tumor were simulated using an Ordinary Differential Equation (ODE). To obtain the tumor radiobiological parameters, we assumed that a tumor consists of two subpopulations, each with its distinctive linear quadratic parameters. The dual compartment cell survival model was constructed as SF(D)=F × exp(-α{sub 1} D-β{sub 1}D{sup 2}) + (1-F) × exp(-α{sub 2}D-β{sub 2}D{sup 2}) for a single fraction of treatment, with F as the fraction of CSC, and α and β describing the radiological properties of each population. Robust least square fitting was performed on clonogenic survival data from one GBM (U373MG) and one NSCLC (H460) cell line. The fit parameters were then used in the ODE model to predict treatment outcome of various treatment schemes. Results: The fit parameters from GBM cell survival data were (F, α{sub 1}, β{sub 1}, α{sub 2}, β{sub 2})=(0.0396, 0.0801, 0.0006, 0.1363, 0.0279), exhibiting two populations with distinctive radiological properties, CSC more radioresistant than DCC. The GBM cell line exhibited significantly poorer tumor control than its single compartment model prediction and NSCLC, which responded well to hypofrationation. The increased radioresistance was due to rapid regrowth of the DCC compartment triggered by its depletion while maintaining a viable CSC population. The rapid regrowth can be reduced by treating dose fractions ≤ 2 Gy with a prolonged treatment period. Conclusion: The interaction between a radioresistant CSC compartment and DCC compartment can explain the poor clinical outcome of GBM after radiotherapy despite dose escalation and hypofractionation attempts. Lower dose fractions result in better treatment

  7. THE FERMI GBM GAMMA-RAY BURST SPECTRAL CATALOG: THE FIRST TWO YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Adam; Burgess, J. Michael; Preece, Robert D.; Briggs, Michael S.; Guiriec, Sylvain; Connaughton, Valerie; Paciesas, William S.; Bhat, P. N.; Chaplin, Vandiver [Physics Department, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Van der Horst, Alexander J.; Meegan, Charles A. [Universities Space Research Association, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Wilson-Hodge, Colleen A.; Fishman, Gerald J. [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Von Kienlin, Andreas; Bissaldi, Elisabetta; Diehl, Roland; Foley, Suzanne [Max-Planck-Institut fuer extraterrestrische Physik, Giessenbachstrasse 1, 85748 Garching (Germany); Fitzpatrick, Gerard [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, Melissa; Giles, Misty [Jacobs Technology, 1500 Perimeter Parkway, Huntsville, AL 35806 (United States); and others

    2012-03-01

    We present systematic spectral analyses of gamma-ray bursts (GRBs) detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center.

  8. Searching for Unmodeled Sources Using the Earth Occultation Data from the Fermi GBM

    CERN Document Server

    Rodi, James; Cherry, Michael L; Camero-Arranz, Ascension; Finger, Mark H; Jenke, Peter; Wilson-Hodge, Colleen A; Chaplin, Vandiver

    2011-01-01

    Employing the 12 NaI detectors in the Fermi GBM, the Earth Occultation Technique (EOT) can be used to measure the fluxes of x-ray and gamma-ray sources. Each time a source passes behind the Earth (or emerges from behind the Earth), a step-like feature is produced in the detector count rate. With a predefined catalog of source positions, the times of the occultation steps can be calculated, the individual steps fit, and the fluxes derived. However, in order to find new sources and generate a complete catalog, a method is needed for generating an image of the sky. An imaging algorithm has been developed to generate all-sky images using the GBM data. Here we present imaging results from ~2.5 years of data in the 12-25 keV and 100-300 keV energy bands.

  9. The Fermi GBM Gamma-Ray Burst Spectral Catalog: The First Two Years

    CERN Document Server

    Goldstein, Adam; Preece, Robert D; Briggs, Michael S; Guiriec, Sylvain; van der Horst, Alexander J; Connaughton, Valerie; Wilson-Hodge, Colleen A; Paciesas, William S; Meegan, Charles A; von Kienlin, Andreas; Bhat, P Narayana; Bissaldi, Elisabetta; Chaplin, Vandiver; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Greiner, Jochen; Gruber, David; Kippen, R Marc; Kouveliotou, Chryssa; McBreen, Sheila; McGlynn, Sinead; Rau, Arne; Tierney, Dave

    2012-01-01

    We present systematic spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first two years of operation. This catalog contains two types of spectra extracted from 487 GRBs, and by fitting four different spectral models, this results in a compendium of over 3800 spectra. The models were selected based on their empirical importance to the spectral shape of many GRBs, and the analysis performed was devised to be as thorough and objective as possible. We describe in detail our procedure and criteria for the analyses, and present the bulk results in the form of parameter distributions. This catalog should be considered an official product from the Fermi GBM Science Team, and the data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  10. Background estimation in a wide-field background-limited instrument such as Fermi GBM

    CERN Document Server

    Fitzpatrick, Gerard; Connaughton, Valerie; Briggs, Michael

    2012-01-01

    The supporting instrument on board the Fermi Gamma-ray Space Telescope, the Gamma-ray Burst Monitor (GBM) is a wide-field gamma-ray monitor composed of 14 individual scintillation detectors, with a field of view which encompasses the entire unocculted sky. Primarily designed as transient monitors, the conventional method for background determination with GBM-like instruments is to time interpolate intervals before and after the source as a polynomial. This is generally sufficient for sharp impulsive phenomena such as Gamma-Ray Bursts (GRBs) which are characterised by impulsive peaks with sharp rises, often highly structured, and easily distinguishable against instrumental backgrounds. However, smoother long lived emission, such as observed in solar flares and some GRBs, would be difficult to detect in a background-limited instrument using this method. We present here a description of a technique which uses the rates from adjacent days when the satellite has approximately the same geographical footprint to dis...

  11. The Successful Synergy of Swift and Fermi/GBM in Magnetars

    Science.gov (United States)

    Kouveliotou, Chryssa

    2011-01-01

    The magnetar rate of discovery has increased dramatically in the last decade. Five sources were discovered in the last three years alone as a result of the very efficient synergy among three X- and .gamma-ray instruments on NASA satellites: the Swift/Burst Alert Telescope (BAT), the Fermi/Gamma ray Burst Monitor (GBM), and the Rossi X-Ray Timing Explorer; RXTE/Proportional Counter Array (PCA). To date, there are approx. 25 magnetar candidates, of which two are (one each) in the Large and Small Magellanic Cloud and the rest reside on the Galactic plane of our Milky Way. I will discuss here the main properties of the Magnetar Population and the common projects that can be achieved with the synergy of Swift and GBM.

  12. NT-25EARLY JAPANESE EXPERIENCE WITH NovoTTF-100A SYSTEM FOR RECURRENT GBM

    OpenAIRE

    Muragaki, Yoshihiro; Nitta, Masayuki; Okumura, Tatsunori; Tabei, Yusuke; MARUYAMA, Takashi; Kaneko, Sadao; Suzuki, Ichiro

    2014-01-01

    BACKGROUND: NovoTTF-100A System is an FDA-approved treatment for recurrent glioblastoma (GBM) and is defined as a device of high unmet medical need in Japan. Subsequently, the device has been made available on a restricted case basis for compassionate use in Japan. Here we report initial experience with 10 patients treated at Tokyo Women's Medical University, Kashiwaba Neurosurgical Hospital and Japanese Red Cross Medical Center. METHODS: Using retrospective chart review, we analyzed patient ...

  13. The Interplanetary Network Supplement to the Fermi GBM Catalog of Cosmic Gamma-Ray Bursts

    CERN Document Server

    Hurley, K; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Svinkin, D S; Briggs, M S; Connaughton, V; Meegan, C; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; von Kienlin, A; Zhang, X; Yamaoka, K; Fukazawa, Y; Hanabata, Y; Ohno, M; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; Del Monte, E; Feroci, M; Marisaldi, M

    2013-01-01

    We present Interplanetary Network (IPN) data for the gamma-ray bursts in the first Fermi Gamma-Ray Burst Monitor (GBM) catalog. Of the 491 bursts in that catalog, covering 2008 July 12 to 2010 July 11, 393 were observed by at least one other instrument in the 9-spacecraft IPN. Of the 393, the localizations of 146 could be improved by arrival time analysis (or "triangulation"). For any given burst observed by the GBM and one other distant spacecraft, triangulation gives an annulus of possible arrival directions whose half-width varies between about 0.4 arcminutes and 32 degrees, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. We find that the IPN localizations intersect the 1 sigma GBM error circles in only 52% of the cases, if no systematic uncertainty is assumed for the latter. If a 6 degree systematic uncertainty is assumed and added in quadrature, the two localization samples agree about 87% of the time, as would be expected. If ...

  14. The Fermi–GBM Three-year X-Ray Burst Catalog

    Science.gov (United States)

    Jenke, P. A.; Linares, M.; Connaughton, V.; Beklen, E.; Camero-Arranz, A.; Finger, M. H.; Wilson-Hodge, C. A.

    2016-08-01

    The Fermi Gamma-ray Burst Monitor (GBM) is an all-sky gamma-ray monitor well known in the gamma-ray burst (GRB) community. Although GBM excels in detecting the hard, bright extragalactic GRBs, its sensitivity above 8 keV and its all-sky view make it an excellent instrument for the detection of rare, short-lived Galactic transients. In 2010 March, we initiated a systematic search for transients using GBM data. We conclude this phase of the search by presenting a three-year catalog of 1084 X-ray bursts. Using spectral analysis, location, and spatial distributions we classified the 1084 events into 752 thermonuclear X-ray bursts, 267 transient events from accretion flares and X-ray pulses, and 65 untriggered gamma-ray bursts. All thermonuclear bursts have peak blackbody temperatures broadly consistent with photospheric radius expansion (PRE) bursts. We find an average rate of 1.4 PRE bursts per day, integrated over all Galactic bursters within about 10 kpc. These include 33 and 10 bursts from the ultra-compact X-ray binaries 4U 0614+09 and 2S 0918-549, respectively. We discuss these recurrence times and estimate the total mass ejected by PRE bursts in our Galaxy.

  15. On the Fermi-GBM Event 0.4 s after GW150914

    Science.gov (United States)

    Greiner, J.; Burgess, J. M.; Savchenko, V.; Yu, H.-F.

    2016-08-01

    In view of the recent report by Connaughton et al., we analyze continuous time-tagged event (TTE) data of Fermi-gamma-ray burst monitor (GBM) around the time of the gravitational-wave event GW 150914. We find that after proper accounting for low-count statistics, the GBM transient event at 0.4 s after GW 150914 is likely not due to an astrophysical source, but consistent with a background fluctuation, removing the tension between the INTEGRAL/ACS non-detection and GBM. Additionally, reanalysis of other short GRBs shows that without proper statistical modeling the fluence of faint events is over-predicted, as verified for some joint GBM–ACS detections of short GRBs. We detail the statistical procedure to correct these biases. As a result, faint short GRBs, verified by ACS detections, with significances in the broadband light curve even smaller than that of the GBM–GW150914 event are recovered as proper non-zero source, while the GBM–GW150914 event is consistent with zero fluence.

  16. Significance of mast cell renal infiltration in patients with anti-GBM nephritis.

    Science.gov (United States)

    Wu, Xiao-Mei; Zhang, Yi-Yan; Zhang, Ming-Chao; Zhang, Li-Hua; Zeng, Cai-Hong; Liu, Zhi-Hong; Tang, Zheng

    2016-07-01

    To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs SCr 8.95 ± 3.66 vs. 4.75 ± 2.73 mg/dL, p < 0.001), urine retinol-binding protein (RBP 29.8 ± 13.9 vs. 15.7 ± 11.5 mg/dL, p = 0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7 ± 21.9 vs. 47.0 ± 33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268 mm(-2) vs. 180 mm(-2), p = 0.045) and CD68 (268 mm(-2) vs. 180 mm(-2), p = 0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes. PMID:27095326

  17. Management of cataract with macular oedema due to diabetes mellitus Type-II and hypertension with grid laser prior to surgery and intra-vitreal bevacizumab (avastin) peroperatively

    International Nuclear Information System (INIS)

    To study the visual outcome in patients subjected to cataract extraction with prior grid laser and intraoperative intravitreal bevacizumab injection. Methods: This prospective case series comprised of 38 patients subjected to phacoemulsification and in the bag intraocular lens implantation at Al-Noor Eye Hospital and Sindh Govt Lyari General Hospital Karachi from January 2007 to December 2008. All the patients had prior macular grid treatment and intra-operative injection of intra-vitreal Avastin. Diabetes mellitus duration, preoperative glycosylated haemoglobin (HbA1c) level and other systemic and local complications of diabetes were recorded. The patients were clinically assessed with bio microscopic examination preoperatively, and postoperatively on day 1, week 1, and in months 1, 2, 3 and 6 respectively. Visual acuity and state of macular oedema was clinically assessed and documented. Results: Out of thirty-eight patients, eighteen were males and 20 were females. Mean duration of diabetes was 9.92 +- 5.5 years (Range 4-16) while that of hypertension was 7.87 +- 3.66 years (Range = 2-15). HbA1c level was 8.36% +- 1.93% (range 6.3 - 12.3). Thirty-one (81.5%) patients had HbA1c level 8.0% or above indicating a poor control. At 6 months of follow up best corrected distant visual acuity of 6/6 to 6/9 was achieved in 23(60.5 %), 6/12 in 11(28.9%) and 6/24 in 4(10.5%) cases while best corrected near acuity of N/6 was achieved in 22(57.8%) N/8 in 12(31.4%) and N/12 in 4(10.5%) cases. At 6 months follow up visual acuity declined in two cases because of uncontrolled diabetes and hypertension. Conclusion: Cataract surgery in diabetic patients with macular oedema and hypertension has a good visual outcome if prior macular grid laser is performed and intra-vitreal anti VEGF is injected during surgery. (author)

  18. VizieR Online Data Catalog: The second Fermi/GBM GRB catalog (4yr) (von Kienlin+, 2014)

    Science.gov (United States)

    von Kienlin, A.; Meegan, C. A.; Paciesas, W. S.; Bhat, P. N.; Bissaldi, E.; Briggs, M. S.; Burgess, J. M.; Byrne, D.; Chaplin, V.; Cleveland, W.; Connaughton, V.; Collazzi, A. C.; Fitzpatrick, G.; Foley, S.; Gibby, M.; Giles, M.; Goldstein, A.; Greiner, J.; Gruber, D.; Guiriec, S.; van der Horst, A. J.; Kouveliotou, C.; Layden, E.; McBreen, S.; McGlynn, S.; Pelassa, V.; Preece, R. D.; Rau, A.; Tierney, D.; Wilson-Hodge, C. A.; Xiong, S.; Younes, G.; Yu, H.-F.

    2014-04-01

    The Fermi Gamma-ray Burst Monitor (GBM), the secondary instrument on board the Fermi Gamma-ray Space Telescope, launched on 2008 June 11, is now operating successfully in space since five years. The GBM instrument extends the energy range of the main instrument, the Large Area Telescope (LAT; 30MeV-300GeV) down to the soft gamma-ray and X-ray energy range (8keV-40MeV). In the first four years of operation since triggering was enabled on 2008 July 12, GBM has triggered 2126 times on a variety of transient events: 954 of these are classified as GRBs (in one case the same GRB triggered GBM twice). The location of a GRB is calculated by comparing the measured individual detector counting rates with a lookup table (LUT), containing a list of relative detector rates for a grid of simulated sky locations. The on-board and on-ground LUTs have resolutions of 5° and 1°, respectively. With this method the limiting accuracy is approximately 8° for on-board locations and approximately 4° for on-ground locations. A detailed investigation of the GBM location accuracy can be found in Connaughton, V., Briggs, M. S., & Goldstein, A. et al. 2014 (ApJS, submitted). (5 data files).

  19. First-year Results of Broadband Spectroscopy of the Brightest Fermi-GBM Gamma-Ray Bursts

    CERN Document Server

    Bissaldi, Elisabetta; Kouveliotou, Chryssa; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Gruber, David; Lichti, Giselher; Bhat, P N; Burgess, J Michael; Chaplin, Vandiver; Diehl, Roland; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty; Goldstein, Adam; Guiriec, Sylvain; van der Horst, Alexander J; Kippen, Marc; Lin, Lin; McBreen, Sheila; Meegan, Charles A; Paciesas, William S; Preece, Robert D; Rau, Arne; Tierney, Dave; Wilson-Hodge, Colleen

    2011-01-01

    We present here our results of the temporal and spectral analysis of a sample of 52 bright and hard gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM) during its first year of operation (July 2008-July 2009). Our sample was selected from a total of 253 GBM GRBs based on each event peak count rate measured between 0.2 and 40MeV. The final sample comprised 34 long and 18 short GRBs. These numbers show that the GBM sample contains a much larger fraction of short GRBs, than the CGRO/BATSE data set, which we explain as the result of our (different) selection criteria and the improved GBM trigger algorithms, which favor collection of short, bright GRBs over BATSE. A first by-product of our selection methodology is the determination of a detection threshold from the GBM data alone, above which GRBs most likely will be detected in the MeV/GeV range with the Large Area Telescope (LAT) onboard Fermi. This predictor will be very useful for future multiwavelength GRB follow ups with ground and ...

  20. $Fermi$ GBM Observations of V404 Cyg During its 2015 Outburst

    CERN Document Server

    Jenke, P A; Homan, Jeroen; Veres, P; Briggs, M S; Burns, E; Connaughton, V; Finger, M H; Hui, M

    2016-01-01

    V404 Cygni was discovered in 1989 by the $Ginga$ X-ray satellite during its only previously observed X-ray outburst and soon after confirmed as a black hole binary. On June 15, 2015, the Gamma Ray Burst Monitor (GBM) triggered on a new outburst of V404 Cygni. We present 13 days of GBM observations of this latest outburst including Earth occultation flux measurements, spectral and temporal analysis. The Earth occultation fluxes reached 30 Crab with detected emission to 100 keV and determined, via hardness ratios, that the source was in a hard state. At high luminosity, spectral analysis between 8 and 300 keV showed that the electron temperature decreased with increasing luminosity. This is expected if the protons and electrons are in thermal equilibrium during an outburst with the electrons cooled by the Compton scattering of softer seed photons from the disk. However, the implied seed photon temperatures are unusually high, suggesting a contribution from another source, such as the jet. No evidence of state t...

  1. Gravitational wave observations may constrain gamma-ray burst models: the case of GW 150914 - GBM

    CERN Document Server

    Veres, P; Goldstein, A; Mészáros, P; Burns, E; Connaughton, V

    2016-01-01

    The possible short gamma-ray burst (GRB) observed by {\\it Fermi}/GBM in coincidence with the first gravitational wave (GW) detection, offers new ways to test GRB prompt emission models. Gravitational wave observations provide previously unaccessible physical parameters for the black hole central engine such as its horizon radius and rotation parameter. Using a minimum jet launching radius from the Advanced LIGO measurement of GW~150914, we calculate photospheric and internal shock models and find that they are marginally inconsistent with the GBM data, but cannot be definitely ruled out. Dissipative photosphere models, however have no problem explaining the observations. Based on the peak energy and the observed flux, we find that the external shock model gives a natural explanation, suggesting a low interstellar density ($\\sim 10^{-3}$ cm$^{-3}$) and a high Lorentz factor ($\\sim 2000$). We only speculate on the exact nature of the system producing the gamma-rays, and study the parameter space of a generic Bl...

  2. Tumour Relapse Prediction Using Multiparametric MR Data Recorded during Follow-Up of GBM Patients

    Directory of Open Access Journals (Sweden)

    Adrian Ion-Margineanu

    2015-01-01

    Full Text Available Purpose. We have focused on finding a classifier that best discriminates between tumour progression and regression based on multiparametric MR data retrieved from follow-up GBM patients. Materials and Methods. Multiparametric MR data consisting of conventional and advanced MRI (perfusion, diffusion, and spectroscopy were acquired from 29 GBM patients treated with adjuvant therapy after surgery over a period of several months. A 27-feature vector was built for each time point, although not all features could be obtained at all time points due to missing data or quality issues. We tested classifiers using LOPO method on complete and imputed data. We measure the performance by computing BER for each time point and wBER for all time points. Results. If we train random forests, LogitBoost, or RobustBoost on data with complete features, we can differentiate between tumour progression and regression with 100% accuracy, one time point (i.e., about 1 month earlier than the date when doctors had put a label (progressive or responsive according to established radiological criteria. We obtain the same result when training the same classifiers solely on complete perfusion data. Conclusions. Our findings suggest that ensemble classifiers (i.e., random forests and boost classifiers show promising results in predicting tumour progression earlier than established radiological criteria and should be further investigated.

  3. The Fermi Gamma-ray Burst Monitor (GBM) Terrestrial Gamma-ray Flash (TGF) Catalog

    Science.gov (United States)

    Stanbro, M.; Briggs, M. S.; Roberts, O.; McBreen, S.; Bhat, N.; Fitzpatrick, G.

    2015-12-01

    We present results from the catalog of Terrestrial Gamma-ray Flashes (TGFs) detected with the Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. The first release, in January 2015, provided data on 2700 TGFs. Updates are extending the catalog at a rate of ~800 TGFs per year. The TGF sample is reliable, with cosmic rays rejected using data both from Fermi GBM and from the Large Area Telescope on Fermi. The online catalog include times (UTC and solar), spacecraft geographic positions, durations, count intensities and other Bayesian Block durations. The catalog includes separate tables for bright TGFs detected by the flight software and for Terrestrial Electron Beams (TEBs). In January 2016 additional data will be released online from correlating these TGFs with sferics detected by the World Wide Lightning Location Network (WWLLN). Maps of sferics in the vicinity of each TGF will be provided, as will the locations and times of sferics found to be associated with TGFs.

  4. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    Directory of Open Access Journals (Sweden)

    Monticone Massimiliano

    2012-08-01

    Full Text Available Abstract Background Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type or highly diffuse single tumor cell infiltration (HD-type. Methods We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM. Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Results Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. Conclusions This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  5. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

    International Nuclear Information System (INIS)

    Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond surgical boundaries. Unveiling mechanisms causing this process is a logic goal to impair the killing capacity of GBM cells by molecular targeting. We noticed that our long-term GBM cultures, established from different patients, may display two categories/types of growth behavior in an orthotopic xenograft model: expansion of the tumor mass and formation of tumor branches/nodules (nodular like, NL-type) or highly diffuse single tumor cell infiltration (HD-type). We determined by DNA microarrays the gene expression profiles of three NL-type and three HD-type long-term GBM cultures. Subsequently, individual genes with different expression levels between the two groups were identified using Significance Analysis of Microarrays (SAM). Real time RT-PCR, immunofluorescence and immunoblot analyses, were performed for a selected subgroup of regulated gene products to confirm the results obtained by the expression analysis. Here, we report the identification of a set of 34 differentially expressed genes in the two types of GBM cultures. Twenty-three of these genes encode for proteins localized to the plasma membrane and 9 of these for proteins are involved in the process of cell adhesion. This study suggests the participation in the diffuse infiltrative/invasive process of GBM cells within the CNS of a novel set of genes coding for membrane-associated proteins, which should be thus susceptible to an inhibition strategy by specific targeting. Massimiliano Monticone and Antonio Daga contributed equally to this work

  6. Swift/BAT and Fermi/GBM observations of SGR J1935+2154 bursts

    Science.gov (United States)

    Lin, Lin

    2016-07-01

    SGR J1935+2154 is a new member of the magnetar family. It was discovered from a short burst which triggered Swift/BAT on 2014 July 5. In 2015 February, the source was detected in the burst active episode again which lasted for about 11 days. We searched for magnetar burst using Bayesian Blocks method through Swift/BAT and Fermi/GBM observations, and totally found 27 events including 3 in 2014 and 24 in 2015. In this talk we will present the result of our detailed analysis of the temporal and spectral properties of these short bursts, and briefly discuss the connection between burst activity and the persistent emission of the source.

  7. CADrx for GBM Brain Tumors: Predicting Treatment Response from Changes in Diffusion-Weighted MRI

    Directory of Open Access Journals (Sweden)

    Matthew S. Brown

    2009-11-01

    Full Text Available The goal of this study was to develop a computer-aided therapeutic response (CADrx system for early prediction of drug treatment response for glioblastoma multiforme (GBM brain tumors with diffusion weighted (DW MR images. In conventional Macdonald assessment, tumor response is assessed nine weeks or more post-treatment. However, we will investigate the ability of DW-MRI to assess response earlier, at five weeks post treatment. The apparent diffusion coefficient (ADC map, calculated from DW images, has been shown to reveal changes in the tumor’s microenvironment preceding morphologic tumor changes. ADC values in treated brain tumors could theoretically both increase due to the cell kill (and thus reduced cell density and decrease due to inhibition of edema. In this study, we investigated the effectiveness of features that quantify changes from pre- and post-treatment tumor ADC histograms to detect treatment response. There are three parts to this study: first, tumor regions were segmented on T1w contrast enhanced images by Otsu’s thresholding method, and mapped from T1w images onto ADC images by a 3D region of interest (ROI mapping tool using DICOM header information; second, ADC histograms of the tumor region were extracted from both pre- and five weeks post-treatment scans, and fitted by a two-component Gaussian mixture model (GMM. The GMM features as well as standard histogram-based features were extracted. Finally, supervised machine learning techniques were applied for classification of responders or non-responders. The approach was evaluated with a dataset of 85 patients with GBM under chemotherapy, in which 39 responded and 46 did not, based on tumor volume reduction. We compared adaBoost, random forest and support vector machine classification algorithms, using ten-fold cross validation, resulting in the best accuracy of 69.41% and the corresponding area under the curve (Az of 0.70.

  8. TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

    International Nuclear Information System (INIS)

    Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the direct effects of TLR9 agonist CpG ODN upon the proliferation and invasion of glioma cells in vitro. RT-PCR and immunofluorescence were used to determine the expression of TLR9 in glioma cell lines and clinical glioma samples. Tissue microarry and immunohistochemistry were applied to evaluated TLR9 expression in 292 newly diagnosed glioma and 13 non-neoplastic brain tissues. We further investigated the effect of CpG ODN on the proliferation and invasion of glioma cells in vitro with MTT assays and matrigel transwell assay respectively. RT-PCR showed that TLR9 expressed in all the glioma samples and glioma cell lines we examined. The tissue array analysis indicated that TLR9 expression is correlated with malignancy of glioma (p < 0.01). Multivariate Cox regression analysis revealed that TLR9 expression is an independent prognostic factor for PFS of GBM patients(P = 0.026). TLR9 agonist CpG ODN has no significant effect on glioma proliferation, but matrigel transwell analysis showed that TLR9 agonist CpG ODN can significantly enhance glioma invasion in vitro. Our data indicated that TLR9 expression increases according to the histopathological grade of glioma, and the TLR9 expression level is related to the PFS of GBM patients. In addition, our findings warrant caution in the directly injection of TLR9 agonist CpG ODN into glioma tissues for the glioma immunotherapy

  9. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    CERN Document Server

    Racusin, J L; Goldstein, A; Connaughton, V; Wilson-Hodge, C A; Jenke, P; Blackburn, L; Briggs, M S; Broida, J; Camp, J; Christensen, N; Hui, C M; Littenberg, T; Shawhan, P; Singer, L; Veitch, J; Bhat, P N; Cleveland, W; Fitzpatrick, G; Gibby, M H; von Kienlin, A; McBreen, S; Mailyan, B; Meegan, C A; Paciesas, W S; Preece, R D; Roberts, O J; Stanbro, M; Veres, P; Zhang, B -B; Ackermann, M; Albert, A; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Bellazzini, R; Bissaldi, E; Blandford, R D; Bloom, E D; Bonino, R; Bregeon, J; Bruel, P; Buson, S; Caliandro, G A; Cameron, R A; Caputo, R; Caragiulo, M; Caraveo, P A; Cavazzuti, E; Charles, E; Chiang, J; Ciprini, S; Costanza, F; Cuoco, A; Cutini, S; D'Ammando, F; de Palma, F; Desiante, R; Digel, S W; Di Lalla, N; Di Mauro, M; Di Venere, L; Drell, P S; Favuzzi, C; Ferrara, E C; Focke, W B; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Giglietto, N; Gill, R; Giroletti, M; Glanzman, T; Granot, J; Green, D; Grove, J E; Guillemot, L; Guiriec, S; Harding, A K; Jogler, T; Johannesson, G; Kamae, T; Kensei, S; Kocevski, D; Kuss, M; Larsson, S; Latronico, L; Li, J; Longo, F; Loparco, F; Lubrano, P; Magill, J D; Maldera, S; Malyshev, D; McEnery, J E; Michelson, P F; Mizuno, T; Morselli, A; Moskalenko, I V; Negro, M; Nuss, E; Omodei, N; Orienti, M; Orlando, E; Ormes, J F; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Principe, G; Raino, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Parkinson, P M Saz; Scargle, J D; Sgro, C; Simone, D; Siskind, E J; Smith, D A; Spada, F; Spinelli, P; Suson, D J; Tajima, H; Thayer, J B; Torres, D F; Troja, E; Uchiyama, Y; Vianello, G; Wood, K S; Wood, M

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, dif- ferences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  10. DISTRIBUTION OF GBM HEPARAN-SULFATE PROTEOGLYCAN CORE PROTEIN AND SIDE-CHAINS IN HUMAN GLOMERULAR-DISEASES

    NARCIS (Netherlands)

    VANDENBORN, J; VANDENHEUVEL, LPWJ; BAKKER, MAH; VEERKAMP, JH; ASSMANN, KJM; WEENING, JJ; BERDEN, JHM

    1993-01-01

    Using monoclonal antibodies (mAbs) recognizing either the core protein or the heparan sulfate (HS) side chain of human GBM heparan sulfate proteoglycan (HSPG), we investigated their glomerular distribution on cryostat sections of human kidney tissues. The study involved 95 biopsies comprising twelve

  11. Duration Distribution of Fermi/GBM Gamma-Ray Bursts: Instrumental Selection Effect of the Bimodal T90 Distribution

    CERN Document Server

    Qin, Ying; Yi, Shuang-Xi; Liang, Yun-Feng; Lin, Lin; Zhang, Bin-Bin; Zhang, Jin; Lu, Hou-Jun; Lu, Rui-Jing; Lu, Lian-Zhong; Zhang, Bing

    2012-01-01

    The durations (T_{90}) of 315 Fermi GRBs detected with the GBM-NaI detectors (8-1000 KeV) by 2011 September are calculated using the Bayesian Block method. We compare the T_{90} distribution of the GBM-NaI sample to that observed with CGRO/BATSE (25-2000 keV), BeppoSAX/GRBM (40-700 KeV), HETE-2/FREGATE (6-80 keV), and Swift/BAT (15-150 keV). We show that the T_{90} distribution of the GBM-NaI GRB sample is bimodal, with a statistical significance level being comparable to that observed with BeppoSAX/GRBM and Swift/BAT but much lower than that observed with CGRO/BATSE. No bimodal T_{90} distribution is found in the HETE-2 GRB sample. Taking T_{90}=2 seconds as the division line between long and short GRBs, the ratio of short to long GRB numbers are 0:95, 51:557, 111:892, 39:253, and 500:1541 for the HETE-2/FREGATE, Swift/BAT, BeppoSAX/GRBM, GBM-NaI, and CGRO/BATSE GRB samples, respectively. These results suggest that the bimodal T_{90} distribution would be due to an instrumental selection effect. We investiga...

  12. ET-54 immunotherapy based on tumor transplant antigen recognition emerges as a promising strategy for recurrent glioblastoma multiform (GBM) patients

    NARCIS (Netherlands)

    Schijns, V.E.J.C.; Pretto, C.; Devillers, L.; Pierre, D.; Hofman, F.

    2014-01-01

    Glioblastoma multiforme (GBM) prognosis remains very poor. This is especially true when the tumors relapse on the current standard of care treatments. Our preclinical data, generated in a rat CNS-1 glioma model in Lewis rats, provided the scientific rationale for a prototype clinical vaccine prepara

  13. Avastin联合黄斑格栅样光凝治疗糖尿病黄斑水肿观察%Clinical investigation of intravitreal Avastin and macular grid photocoagulation for diabetic macular edema

    Institute of Scientific and Technical Information of China (English)

    胡忆群; 陈青山; 方敏; 佘洁婷; 杨旭

    2012-01-01

    Objective To investigate the effects of intravitreal Avastin combined with macular grid photocoagulation (MGP) for diabetic macular edema (DME).Methods Fouty-five DME patients (59eyes) were divided into two groups randomly,26 eyes received MGP (MGP Group) and 33 eyes received intravitreal injection of 1.5 mg Avastin followed by MGP (combined Group).All eyes underwent a complete ophthalmic examination including BCVA,IOP,and OCT at baseline and 1,3,6months after treatment.The outcome measures were the changes compared with baseline in BCVA,changes in CMT.Dates were analyzed using the paired t-test and one-way ANOVA (SPSS 13.0).The BCVA levels were converted to logMAR equivalents and analyzed.P < 0.05 was considered statistically significant.Results After treatment,the improvement in CMT in the MGP group was significant,yet there was no significant improvement in the mean BCVA (logMAR).The improvement in mean CMT was significant at 1,3,6 month (P < 0.01),with corresponding improvement in the combined group.The BCVA did not deteriorate below baseline in all eyes included in the study,except two eyes in the MGP group.No complication related to the intravitreal injection occurred.Conclusions.Combination treatment with intravitreal Avastin and macular grid photocoagulation for DME is well tolerated,with a significantly improvement in BCVA and CMT.This suggests combination treatment with intravitreal Avastin and macular grid photocoagulation for diabetic merits further investigation.%目的 观察玻璃体腔注射Avastin联合黄斑格栅样光凝治疗糖尿病黄斑水肿的效果.方法 临床病例对照研究.对2010年5月至2011年5月在深圳市眼科医院就诊病人,将符合纳入标准并经眼底荧光造影(fundus fluorescein angiography,FFA)及相干光断层扫描(optical coherence tomography,OCT)确诊为糖尿病黄斑水肿(diabetic macular edema,DME)的患者45例59只眼,随机分为A、B二组,A组21例26只眼;B组24例33只眼.A组:单纯

  14. Searching the Gamma-ray Sky for Counterparts to Gravitational Wave Sources: Fermi GBM and LAT Observations of LVT151012 and GW151226

    OpenAIRE

    Racusin, J. L.; Burns, E; Goldstein, A.; Connaughton, V.; C. A. Wilson-Hodge(NASA/Marshall Space Flight Center, Huntsville, United States); Jenke, P.; Blackburn, L.; Briggs, M. S.; Broida, J.; Camp, J.; Christensen, N.; Hui, C. M.; Littenberg, T.; Shawhan, P.; Singer, L.

    2016-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candi- date LVT151012. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for char- acterizing the upper limits across a large area of the sky. Due to the partial GB...

  15. The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

    CERN Document Server

    Gruber, David; von Ahlefeld, Victoria Weller; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Byrne, Dave; Cleveland, William H; Connaughton, Valerie; Fishman, Gerald J; Fitzpatrick, Gerard; Foley, Suzanne; Gibby, Melissa; Giles, Misty M; Greiner, Jochen; Guiriec, Sylvain; van der Horst, Alexander J; von Kienlin, Andreas; Kouveliotou, Chryssa; Layden, Emily; Lin, Lin; Meegan, Charles A; McGlynn, Sinéad; Paciesas, William S; Pelassa, Véronique; Preece, Robert D; Rau, Arne; Wilson-Hodge, Colleen A; Xiong, Shaolin; Yu, Hoi-Fung

    2014-01-01

    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).

  16. GBM Monitoring of Cyg X-1 During the Recent State Transition

    CERN Document Server

    Case, G L; Cherry, M L; Camero-Arranz, A; Finger, M; Jenke, P; Wilson-Hodge, C A; Chaplin, V

    2011-01-01

    Cygnus X-1 is a high-mass x-ray binary with a black hole compact object. It is normally extremely bright in hard x-rays and low energy gamma rays and resides in the canonical hard spectral state. Recently, however, Cyg X-1 made a transition to the canonical soft state, with a rise in the soft x-ray flux and a decrease in the flux in the hard x-ray and low energy gamma-ray energy bands. We have been using the Gamma-Ray Burst Monitor on Fermi to monitor the fluxes of a number of sources in the 8--1000 keV energy range, including Cyg X-1. We present light curves of Cyg X-1 showing the flux decrease in hard x-ray and low energy gamma-ray energy bands during the state transition as well as the several long flares observed in these higher energies during the soft state. We also present preliminary spectra from GBM for the pre-transition state, showing the spectral evolution to the soft state, and the post-transition state.

  17. Restriction spectrum imaging of bevacizumab-related necrosis in a patient with GBM

    Directory of Open Access Journals (Sweden)

    Nikdokht eFarid

    2013-09-01

    Full Text Available Importance:With the increasing use of antiangiogenic agents in the treatment of high grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with histopathologic validation, confirming that this region of restricted diffusion represents necrosis and not viable tumor. Observations:We present a case report of a 52-year-old man with GBM treated with temozolomide, radiation, and concurrent bevacizumab following gross total resection. The patient underwent sequential MRI's which included restriction-spectrum imaging (RSI, an advanced diffusion-weighted imaging (DWI technique, and MR perfusion. Following surgery, the patient developed an area of restricted diffusion on RSI which became larger and more confluent over the next several months. Marked signal intensity on RSI and very low cerebral blood volume (CBV on MR perfusion led us to favor bevacizumab-related necrosis over recurrent tumor. Subsequent histopathologic evaluation confirmed coagulative necrosis.Conclusions and Relevance:Our report increases the number of pathologically-proven cases of bevacizumab-related necrosis in the literature from three to four. Furthermore, our case demonstrates this phenomenon on RSI, which has been shown to have good sensitivity to restricted diffusion.

  18. Testing the anisotropy in the angular distribution of $Fermi$/GBM gamma-ray bursts

    CERN Document Server

    Tarnopolski, Mariusz

    2015-01-01

    Gamma-ray bursts (GRBs) were confirmed to be of extragalactic origin due to their isotropic angular distribution, combined with the fact that they exhibited an intensity distribution that deviated strongly from the $-3/2$ power law. This finding was later confirmed with the first redshift, equal to at least $z=0.835$, measured for GRB970508. Despite this result, the data from $CGRO$/BATSE and $Swift$/BAT indicate that long GRBs are indeed distributed isotropically, but the distribution of short GRBs is anisotropic. $Fermi$/GBM has detected 1669 GRBs up to date, and their sky distribution is examined in this paper. A number of statistical tests is applied: nearest neighbour analysis, fractal dimension, dipole and quadrupole moments of the distribution function decomposed into spherical harmonics, binomial test, and the two point angular correlation function. Monte Carlo benchmark testing of each test is performed in order to evaluate its reliability. It is found that short GRBs are distributed anisotropically ...

  19. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

    Science.gov (United States)

    Raizer, J. J.; Giglio, P.; Hu, J.; Groves, M.; Merrell, R.; Conrad, C.; Phuphanich, S.; Puduvalli, V. K.; Loghin, M.; Paleologos, N.; Yuan, Y.; Liu, D.; Rademaker, A.; Yung, W. K.; Vaillant, B.; Rudnick, J.; Chamberlain, M.; Vick, N.; Grimm, S.; Tremont-Lukats, I. W.; De Groot, J.; Aldape, K.; Gilbert, M. R.

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29–75) and median KPS was 90 (70–100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2–47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  20. ET-54IMMUNOTHERAPY BASED ON TUMOR TRANSPLANT ANTIGEN RECOGNITION EMERGES AS A PROMISING STRATEGY FOR RECURRENT GLIOBLASTOMA MULTIFORME (GBM) PATIENTS

    OpenAIRE

    Schijns, Virgil; Pretto, Chrystel; Devillers, Laurent; Pierre, Denis; Hofman, Florence; Kruse, Carol; Chen, Thomas; Oertel, Joachim; Hantos, Peter; Bota, Daniela; Stathopoulos, Apostolos

    2014-01-01

    Glioblastoma multiforme (GBM) prognosis remains very poor. This is especially true when the tumors relapse on the current standard of care treatments. Our preclinical data, generated in a rat CNS-1 glioma model in Lewis rats, provided the scientific rationale for a prototype clinical vaccine preparation, named ERC 1671 (Gliovac). ERC1671 is composed of autologous antigens, derived from the patient's own tumour tissue, and administered in conjunction with allogeneic antigens from histologicall...

  1. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    OpenAIRE

    Bente Sandvei Skeie; Jian Wang; Ernest Dodoo; Jan Ingeman Heggdal; Janne Grønli; Linda Sleire; Sidsel Bragstad; Ganz, Jeremy C.; Martha Chekenya; Sverre Mørk; Paal-Henning Pedersen; Per Øyvind Enger

    2013-01-01

    Object. Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs). However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS...

  2. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients.

    Science.gov (United States)

    Raizer, J J; Giglio, P; Hu, J; Groves, M; Merrell, R; Conrad, C; Phuphanich, S; Puduvalli, V K; Loghin, M; Paleologos, N; Yuan, Y; Liu, D; Rademaker, A; Yung, W K; Vaillant, B; Rudnick, J; Chamberlain, M; Vick, N; Grimm, S; Tremont-Lukats, I W; De Groot, J; Aldape, K; Gilbert, M R

    2016-01-01

    Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is limited. How to better treat patients with unmethylated MGMT is unknown. We performed a trial combining erlotinib and bevacizumab in unmethylated GBM patients after completion of radiation (RT) and TMZ. GBM patients with an unmethylated MGMT promoter were trial eligible. Patient received standard RT (60 Gy) and TMZ (75 mg/m2 × 6 weeks) after surgical resection of their tumor. After completion of RT they started erlotinib 150 mg daily and bevacizumab 10 mg/kg every 2 weeks until progression. Imaging evaluations occurred every 8 weeks. The primary endpoint was overall survival. Of the 48 unmethylated patients enrolled, 46 were evaluable (29 men and 17 women); median age was 55.5 years (29-75) and median KPS was 90 (70-100). All patients completed RT with TMZ. The median number of cycles (1 cycle was 4 weeks) was 8 (2-47). Forty-one patients either progressed or died with a median progression free survival of 9.2 months. At a follow up of 33 months the median overall survival was 13.2 months. There were no unexpected toxicities and most observed toxicities were categorized as CTC grade 1 or 2. The combination of erlotinib and bevacizumab is tolerable but did not meet our primary endpoint of increasing survival. Importantly, more trials are needed to find better therapies for GBM patients with an unmethylated MGMT promoter. PMID:26476729

  3. ET-66ER-STRESS INDUCING DRUGS SENSITIZES GBM TO TEMOZOLOMIDE THROUGH DOWNREGULATION OF MGMT AND INDUCTION OF REGULATED NECROSIS

    Science.gov (United States)

    Xipell, Enric; Martínez-Velez, Naiara; Vera-Cano, Beatriz; Idoate, Miguel Angel; Garzón, Antonia García; Acanda, Arlet M.; Fueyo, Juan; Gomez-Manzano, Candelaria; Alonso, Marta M

    2014-01-01

    Termozolamide (TMZ) is the standard treatment against GBM, unfortunately its therapeutic effect is limited due to the expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). Therefore, approaches that overcome the resistance to TMZ could be feasible therapeutic alternatives for this deadly disease. Endoplasmic reticulum (ER) stress suppresses several DNA damage proteins through the unfolding protein response. In this work we sought to evaluate whether ER-stress inducing drugs were able to downmodulate MGMT and sensitize GBM cells to TMZ treatment. Salinomycin (SLM) is a potassium ionophore that has proven effective against cancer stem cells and a possible candidate to induce ER stress. Our data showed that SLM triggered ER stress that was accompanied by the downregulation of MGMT. We obtained the same results with other ER stress inducing drugs (thapsigergin, tunicamycin) suggesting that this is a general mechanism. Chemical inhibition of ER stress reverted the abrogation of MGMT downregulation. Of importance, SLM induced an aberrant autophagic flux that led to regulated necrosis cell death mediated by the action of AIF protein, which induces DNA damage when localized in the nucleus. Combination of TMZ and SLM displayed a potent antitumor effect in vitro and in vivo in mice bearing a GBM stem cell model. Combination treatment induced a significant increase in DNA damage as shown by H2AX activation and PARP. Moreover, we observed AIF in the nucleus, as a result of the regulated necrosis, furthering favoring the DNA damage. Combination treatment showed an increment of the median survival and of long term survivors. Moreover tissue analysis confirmed a dramatic increase in the level of DNA damage. Altogether our results showed that combination treatment induces a potent antiglioma effect in vitro and in vivo. Our data uncover the possibility to exploit ER stress and regulated necrosis as therapeutic strategies for GBM treatment.

  4. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Wilson-Hodge, Colleen A; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Jenke, Peter; Chaplin, Vandiver; Beklen, Elif; Finger, Mark; Bhat, Narayan; Briggs, Michael S; Connaughton, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2012-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 102 sources, including 41 low-mass X-ray binary/neutron star systems, 33 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.

  5. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model

    Directory of Open Access Journals (Sweden)

    Bente Sandvei Skeie

    2013-01-01

    Full Text Available Object. Gamma knife surgery (GKS may be used for recurring glioblastomas (GBMs. However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments. Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS. Methods. GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI. The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment. Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test. Results. In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001. In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006. Polynuclear macrophages and fibrosis was seen in groups subjected to GKS. Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04. Conclusion. GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.

  6. Fermi/GBM observations of the ultra-long GRB 091024: A burst with an optical flash

    CERN Document Server

    Gruber, D; Foley, S; Nardini, M; Burlon, D; Rau, A; Bissaldi, E; von Kienlin, A; McBreen, S; Greiner, J; Bhat, P N; Briggs, M S; Burgess, J M; Chaplin, V L; Connaughton, V; Diehl, R; Fishman, G J; Gibby, M H; Giles, M M; Goldstein, A; Guiriec, S; van der Horst, A J; Kippen, R M; Kouveliotou, C; Lin, L; Meegan, C A; Paciesas, W S; Preece, R D; Tierney, D; Wilson-Hodge, C

    2011-01-01

    In this paper we examine gamma-ray and optical data of GRB 091024, a gamma-ray burst (GRB) with an extremely long duration of T90~1020 s, as observed with the Fermi Gamma-Ray Burst Monitor (GBM). We present spectral analysis of all three distinct emission episodes using data from Fermi/GBM. Because of the long nature of this event, many ground-based optical telescopes slewed to its location within a few minutes and thus were able to observe the GRB during its active period. We compare the optical and gamma-ray light curves. Furthermore, we estimate a lower limit on the bulk Lorentz factor from the variability and spectrum of the GBM light curve and compare it with that obtained from the peak time of the forward shock of the optical afterglow. From the spectral analysis we note that, despite its unusually long duration, this burst is similar to other long GRBs, i.e. there is spectral evolution (both the peak energy and the spectral index vary with time) and spectral lags are measured. We find that the optical ...

  7. The optical identifcation of events with poorly defined locations: The case of the Fermi GBM GRB140801A

    CERN Document Server

    Lipunov, V M; Pruzhinskaya, M V; Postigo, A de Ugarte; Pelassa, V; Tsvetkova, A E; Sokolov, I V; Kann, D A; Xu, Dong; Gorbovskoy, E S; Krushinski, V V; Kornilov, V G; Balanutsa, P V; Boronina, S V; Budnev, N M; Cano, Z; Castro-Tirado, A J; Chazov, V V; Connaughton, V; Delvaux, C; Frederiks, D D; Fynbo, J F U; Gabovich, A V; Goldstein, A; Greiner, J; Gress, O A; Ivanov, K I; Jakobsson, P; Klose, S; Knust, F; Komarova, V N; Konstantinov, E; Krylov, A V; Kuvshinov, D A; Kuznetsov, A S; Lipunova, G V; Moskvitin, A S; Pal'shin, V D; Pandey, S B; Poleshchuk, V A; Schmidl, S; Sergienko, Yu P; Sinyakov, E V; Schulze, S; Sokolov, V V; Sokolova, T N; Sparre, M; Thone, C C; Tlatov, A G; Tyurina, N V; Ulanov, M V; Yazev, S A; Yurkov, V V

    2015-01-01

    We report the early discovery of the optical afterglow of gamma-ray burst (GRB) 140801A in the 137 deg$^2$ 3-$\\sigma$ error-box of the Fermi Gamma-ray Burst Monitor (GBM). MASTER is the only observatory that automatically react to all Fermi alerts. GRB 140801A is one of the few GRBs whose optical counterpart was discovered solely from its GBM localization. The optical afterglow of GRB 140801A was found by MASTER Global Robotic Net 53 sec after receiving the alert, making it the fastest optical detection of a GRB from a GBM error-box. Spectroscopy obtained with the 10.4-m Gran Telescopio Canarias and the 6-m BTA of SAO RAS reveals a redshift of $z=1.32$. We performed optical and near-infrared photometry of GRB 140801A using different telescopes with apertures ranging from 0.4-m to 10.4-m. GRB 140801A is a typical burst in many ways. The rest-frame bolometric isotropic energy release and peak energy of the burst is $E_\\mathrm{iso} = 5.54_{-0.24}^{+0.26} \\times 10^{52}$ erg and $E_\\mathrm{p, rest}\\simeq280$ keV,...

  8. MIF-CD74 GUIDED THERAPEUTIC STRATEGY FOR THE UPFRONT TREATMENT OF GBM PATIENTS WITH AN UNMETHYLATED MGMT PROMOTER

    Science.gov (United States)

    McDonald, Kerrie L; Ha, Wendy; Sevim, Hatice

    2014-01-01

    BACKGROUND: Promoter methylation of the DNA repair gene, MGMT is associated with improved treatment outcome for newly diagnosed glioblastoma (GBM) treated with standard chemoradiation. Currently, there are no universally effective systemic treatments available for patients with an unmethylated MGMT promoter or treatments for patients whose tumor recurs after primary treatment, irrespective of MGMT methylation status. We used SELDI-TOF MS to identify low molecular weight proteins associated with poor survival. We report a new therapeutic strategy with potential to overcome the drug resistance conferred by MGMT when applied as an adjunct therapy to the standard chemoradiation for patients. METHODS: We screened the low molecular weight proteome of patients' tumors, which were non-responsive to chemoradiotherapy (survival <12 months). Proteins of significant abundance in the non-responsive patients were purified, identified and validated in a larger cohort of GBM (n = 230). Inhibitors were sourced and efficacy of the drug was tested in patient derived tumor models. RESULTS: High expression of the inflammatory related protein Macrophage Inhibitory Factor (MIF) and its receptor, CD74 were found in patients who were non-responsive to chemoradiation. Heightened expression of both MIF and CD74 were identified in 57% of GBM (n = 230) and co-segregated with poor prognosis. CD74 forms a complex with CD44 at the cell surface. After MIF binds to the CD74/44 complex, Src is recruited. Src recruitment then initiates the activation of multiple pathways including Ras/MAPK and Akt resulting in tumor proliferation. Pro-angiogenic effects have also been attributed to this complex. Because of its involvement in tumorigenesis, inhibition of the MIF/CD74/CD44 complex with specific inhibitors in combination with chemoradiotherapy will likely abate the resistance to standard treatment and result in longer survival. Ibudilast (AV411; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a] pyridine) is an

  9. A Novel GBM Saliency Detection Model Using Multi-Channel MRI.

    Directory of Open Access Journals (Sweden)

    Subhashis Banerjee

    Full Text Available The automatic computerized detection of regions of interest (ROI is an important step in the process of medical image processing and analysis. The reasons are many, and include an increasing amount of available medical imaging data, existence of inter-observer and inter-scanner variability, and to improve the accuracy in automatic detection in order to assist doctors in diagnosing faster and on time. A novel algorithm, based on visual saliency, is developed here for the identification of tumor regions from MR images of the brain. The GBM saliency detection model is designed by taking cue from the concept of visual saliency in natural scenes. A visually salient region is typically rare in an image, and contains highly discriminating information, with attention getting immediately focused upon it. Although color is typically considered as the most important feature in a bottom-up saliency detection model, we circumvent this issue in the inherently gray scale MR framework. We develop a novel pseudo-coloring scheme, based on the three MRI sequences, viz. FLAIR, T2 and T1C (contrast enhanced with Gadolinium. A bottom-up strategy, based on a new pseudo-color distance and spatial distance between image patches, is defined for highlighting the salient regions in the image. This multi-channel representation of the image and saliency detection model help in automatically and quickly isolating the tumor region, for subsequent delineation, as is necessary in medical diagnosis. The effectiveness of the proposed model is evaluated on MRI of 80 subjects from the BRATS database in terms of the saliency map values. Using ground truth of the tumor regions for both high- and low- grade gliomas, the results are compared with four highly referred saliency detection models from literature. In all cases the AUC scores from the ROC analysis are found to be more than 0.999 ± 0.001 over different tumor grades, sizes and positions.

  10. The Problem with Briefs, in Brief

    Science.gov (United States)

    Conaway, Carrie L.

    2013-01-01

    Policy briefs written by academics--the kind typically published in "Education Finance and Policy"--should be a crucial source of information for policy makers. Yet too frequently these briefs fail to garner the consideration they deserve. Their authors are too focused on the potential objections of their fellow academics, who are…

  11. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

    Directory of Open Access Journals (Sweden)

    Nameeta Shah

    Full Text Available O⁶-methylguanine DNA-methyltransferase (MGMT promoter methylation has been identified as a potential prognostic marker for glioblastoma patients. The relationship between the exact site of promoter methylation and its effect on gene silencing, and the patient's subsequent response to therapy, is still being defined. The aim of this study was to comprehensively characterize cytosine-guanine (CpG dinucleotide methylation across the entire MGMT promoter and to correlate individual CpG site methylation patterns to mRNA expression, protein expression, and progression-free survival. To best identify the specific MGMT promoter region most predictive of gene silencing and response to therapy, we determined the methylation status of all 97 CpG sites in the MGMT promoter in tumor samples from 70 GBM patients using quantitative bisulfite sequencing. We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival. Using this data, we propose a new classification scheme utilizing methylation data from across the entire promoter and show that an analysis based on this approach, which we call 3R classification, is predictive of progression-free survival (HR  = 5.23, 95% CI [2.089-13.097], p<0.0001. To adapt this approach to the clinical setting, we used a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA test based on the 3R classification and show that this test is both feasible in the clinical setting and predictive of progression free survival (HR  = 3.076, 95% CI [1.301-7.27], p = 0.007. We discuss the potential advantages of a test based on this promoter-wide analysis and compare it to the commonly used methylation-specific PCR test. Further prospective validation of these two methods in a large independent patient cohort will be needed to confirm the added value of promoter wide analysis of MGMT methylation in the clinical

  12. The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Xing WK

    2015-06-01

    Full Text Available Wei-kang Xing,1 Chuan Shao,2 Zhen-yu Qi,1 Chao Yang,1 Zhong Wang1 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 2Department of Neurosurgery, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China Background: Standard treatment for high-grade glioma (HGG includes surgery followed by radiotherapy and/or chemotherapy. Insertion of carmustine wafers into the resection cavity as a treatment for malignant glioma is currently a controversial topic among neurosurgeons. Our meta-analysis focused on whether carmustine wafer treatment could significantly benefit the survival of patients with newly diagnosed glioblastoma multiforme (GBM.Method: We searched the PubMed and Web of Science databases without any restrictions on language using the keywords “Gliadel wafers”, “carmustine wafers”, “BCNU wafers”, or “interstitial chemotherapy” in newly diagnosed GBM for the period from January 1990 to March 2015. Randomized controlled trials (RCTs and cohort studies/clinical trials that compared treatments designed with and without carmustine wafers and which reported overall survival or hazard ratio (HR or survival curves were included in this study. Moreover, the statistical analysis was conducted by the STATA 12.0 software.Results: Six studies including two RCTs and four cohort studies, enrolling a total of 513 patients (223 with and 290 without carmustine wafers, matched the selection criteria. Carmustine wafers showed a strong advantage when pooling all the included studies (HR =0.63, 95% confidence interval (CI =0.49–0.81; P=0.019. However, the two RCTs did not show a statistical increase in survival in the group with carmustine wafer compared to the group without it (HR =0.51, 95% CI =0.18–1.41; P=0.426, while the cohort studies demonstrated a significant survival increase (HR =0.59, 95% CI =0.44–0.79; P<0.0001.Conclusion

  13. BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.

    Science.gov (United States)

    Chen, Chien-Min; Syu, Jhih-Pu; Way, Tzong-Der; Huang, Li-Jiau; Kuo, Sheng-Chu; Lin, Chung-Tien; Lin, Chih-Li

    2015-11-01

    Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti‑glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti‑proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell‑cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy‑mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B‑induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken together, the present results provide molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug‑resistant glioblastoma cells to the chemotherapeutic agent TMZ.

  14. The Fermi GBM gamma-ray burst time-resolved spectral catalog: brightest bursts in the first four years

    CERN Document Server

    Yu, Hoi-Fung; Greiner, Jochen; Bhat, P Narayana; Bissaldi, Elisabetta; Briggs, Michael S; Cleveland, William H; Connaughton, Valerie; Goldstein, Adam; von Kienlin, Andreas; Kouveliotou, Chryssa; Mailyan, Bagrat; Meegan, Charles A; Paciesas, William S; Rau, Arne; Roberts, Oliver J; Veres, Péter; Wilson-Hodge, Colleen; Zhang, Bin-Bin; van Eerten, Hendrik J

    2016-01-01

    We aim to obtain high-quality time-resolved spectral fits of gamma-ray bursts (GRBs) observed by the Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-ray Space Telescope. We perform time-resolved spectral analysis with high temporal and spectral resolution of the brightest bursts observed by Fermi GBM in its first 4 years of mission. We present the complete catalog containing 1,491 spectra from 81 bursts with high spectral and temporal resolution. Distributions of parameters, statistics of the parameter populations, parameter-parameter and parameter-uncertainty correlations, and their exact values are obtained and presented as main results in this catalog. We report a criterion that is robust enough to automatically distinguish between different spectral evolutionary trends between bursts. We also search for plausible blackbody emission components and find that only 3 bursts (36 spectra in total) show evidence of a pure Planck function. It is observed that the averaged time-resolved low-energy power-law...

  15. Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

    CERN Document Server

    Jenke, P; Case, Gary L; Cherry, Michael L; Rodi, James; Camero-Arranz, Ascension; Chaplin, Vandiver; Beklen, Elif; Finger, Mark H; Bhat, Narayana; Briggs, Michael S; Connaughto, Valerie; Greiner, Jochen; Kippen, R Marc; Meegan, Charles A; Paciesas, William S; Preece, Robert; von Kienlin, Andreas

    2013-01-01

    The Gamma ray Burst Monitor (GBM) on board Fermi Gamma-ray Space Telescope has been providing continuous data to the astronomical community since 2008 August 12. We will present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. Although the occultation technique is in principle quite simple, in practice there are many complications including the dynamic instrument response, source confusion, and scattering in the Earth's atmosphere, which will be described. We detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary/neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to ot...

  16. First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

    CERN Document Server

    Case, Gary L; Rodi, James C; Jenke, Peter; Wilson-Hodge, Colleen A; Finger, Mark H; Meegan, Charles A; Camero-Arranz, Ascencion; Beklen, Elif; Bhat, P Narayan; Briggs, Michael S; Chaplin, Vandiver; Connaughton, Valerie; Paciesas, William S; Preece, Robert; Kippen, R Marc; von Kienlin, Andreas; Griener, Jochen

    2010-01-01

    The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transien...

  17. Kepler K2 Observations of Sco X-1: Orbital Modulations and Correlations with Fermi GBM and MAXI

    CERN Document Server

    Hynes, R I; Baum, Z A; Hsu, C -C; Cherry, M L; Scaringi, S

    2016-01-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high state correlation arises promptly with at most a few minutes lag. We attribute this to thermal ...

  18. Prescribing Brief Psychotherapy

    OpenAIRE

    Schuyler, Dean

    2000-01-01

    Brief psychotherapy has demonstrated its effectiveness in treating emotional disorders and helping with problems that typically present to primary care physicians. Because practitioners receive little instruction about this treatment option and often have erroneous preconceived ideas about it, psychotherapy remains underprescribed. Effective brief therapy enables the patient to problem-solve, facilitates the relationship with the provider, and ultimately clarifies the patient's situation. Ref...

  19. Mississippi: State Policy Brief

    Science.gov (United States)

    Corbett, Julie

    2014-01-01

    This brief is one in a series highlighting state policies, regulations, practices, laws, or other tools intended to create the necessary conditions for school and/or district turnaround. Each brief includes an overview of the relevant turnaround tool, its development process, its impact, and lessons learned that could assist other education…

  20. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM

    Science.gov (United States)

    Crawford, Forrest W.; Khayal, Inas S.; McGue, Colleen; Saraswathy, Suja; Pirzkall, Andrea; Cha, Soonmee; Lamborn, Kathleen R.; Chang, Susan M.; Berger, Mitchel S.

    2010-01-01

    Glioblastoma Multiforme (GBM) are heterogeneous lesions, both in terms of their appearance on anatomic images and their response to therapy. The goal of this study was to evaluate the prognostic value of parameters derived from physiological and metabolic images of these lesions. Fifty-six patients with GBM were scanned immediately before surgical resection using conventional anatomical MR imaging and, where possible, perfusion-weighted imaging, diffusion-weighted imaging, and proton MR spectroscopic imaging. The median survival time was 517 days, with 15 patients censored. Absolute anatomic lesion volumes were not associated with survival but patients for whom the combined volume of contrast enhancement and necrosis was a large percentage of the T2 hyperintense lesion had relatively poor survival. Other volumetric parameters linked with less favorable survival were the volume of the region with elevated choline to N-acetylaspartate index (CNI) and the volume within the T2 lesion that had apparent diffusion coefficient (ADC) less than 1.5 times that in white matter. Intensity parameters associated with survival were the maximum and the sum of levels of lactate and of lipid within the CNI lesion, as well as the magnitude of the 10th percentile of the normalized ADC within the contrast-enhancing lesion. Patients whose imaging parameters indicating that lesions with a relatively large percentage with breakdown of the blood brain barrier or necrosis, large regions with abnormal metabolism or areas with restricted diffusion have relatively poor survival. These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials. PMID:19009235

  1. SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

    Directory of Open Access Journals (Sweden)

    Nicolas M Bertagnolli

    Full Text Available To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA microarrays. We show that the SVD identifies the transcript length distribution functions as "asymmetric generalized coherent states" from the DNA microarray data and with no a-priori assumptions. Comparing subsets of human and yeast transcripts of the same gene ontology annotations, we find that in both disparate eukaryotes, transcripts involved in protein synthesis or mitochondrial metabolism are significantly shorter than typical, and in particular, significantly shorter than those involved in glucose metabolism. Comparing the subsets of human transcripts that are overexpressed in glioblastoma multiforme (GBM or normal brain tissue samples from The Cancer Genome Atlas, we find that GBM maintains normal brain overexpression of significantly short transcripts, enriched in transcripts that are involved in protein synthesis or mitochondrial metabolism, but suppresses normal overexpression of significantly longer transcripts, enriched in transcripts that are involved in glucose metabolism and brain activity. These global relations among transcript length, cellular metabolism and tumor development suggest a previously unrecognized physical mode for tumor and normal cells to differentially regulate metabolism in a transcript length-dependent manner. The identified distribution functions support a previous hypothesis from mathematical modeling of evolutionary forces that act upon transcript length in the manner of the restoring force of the harmonic oscillator.

  2. Kepler K2 observations of Sco X-1: orbital modulations and correlations with Fermi GBM and MAXI

    Science.gov (United States)

    Hynes, Robert I.; Schaefer, Bradley E.; Baum, Zachary A.; Hsu, Ching-Cheng; Cherry, Michael L.; Scaringi, Simone

    2016-07-01

    We present a multi-wavelength study of the low-mass X-ray binary Sco X-1 using Kepler K2 optical data and Fermi GBM and MAXI X-ray data. We recover a clear sinusoidal orbital modulation from the Kepler data. Optical fluxes are distributed bimodally around the mean orbital light curve, with both high and low states showing the same modulation. The high state is broadly consistent with the flaring branch of the Z-diagram and the low state with the normal branch. We see both rapid optical flares and slower dips in the high state, and slow brightenings in the low state. High-state flares exhibit a narrow range of amplitudes with a striking cut-off at a maximum amplitude. Optical fluxes correlate with X-ray fluxes in the high state, but in the low state they are anti-correlated. These patterns can be seen clearly in both flux-flux diagrams and cross-correlation functions and are consistent between MAXI and GBM. The high-state correlation arises promptly with at most a few minutes lag. We attribute this to thermal reprocessing of X-ray flares. The low-state anti-correlation is broader, consistent with optical lags of between zero and 30 min, and strongest with respect to high-energy X-rays. We suggest that the decreases in optical flux in the low state may reflect decreasing efficiency of disc irradiation, caused by changes in the illumination geometry. These changes could reflect the vertical extent or covering factor of obscuration or the optical depth of scattering material.

  3. Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters.

    Directory of Open Access Journals (Sweden)

    Vikas Chandra

    Full Text Available Hedgehog (Hh signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM, a lethal malignancy of the central nervous system (CNS. By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7 between GLI1 and PTCH1 mRNA expression--as a hallmark of the canonical Hh-pathway activity in this malignancy. GLI1 mRNA expression varied in 3 orders of magnitude among the GBM patients of the same cohort showing a single continuous distribution-unlike the discrete high/low-GLI1 mRNA expressing clusters of medulloblastoma (MB. When compared with MB as a reference, the median GLI1 mRNA expression in GBM appeared 14.8 fold lower than that of the "high-Hh" cluster of MB but 5.6 fold higher than that of the "low-Hh" cluster of MB. Next, we demonstrated statistically significant up- and down-regulation of GLI1 mRNA expressions in GBM patient-derived low-passage neurospheres in vitro by sonic hedgehog ligand-enriched conditioned media (shh-CM and by Hh-inhibitor drug vismodegib respectively. We also showed clinically achievable dose (50 μM of vismodegib alone to be sufficient to induce apoptosis and cell cycle arrest in these low-passage GBM neurospheres in vitro. Vismodegib showed an effect on the neurospheres, both by down-regulating GLI1 mRNA expression and by inducing apoptosis/cell cycle arrest, irrespective of their relative endogenous levels of GLI1 mRNA expression. We conclude from our study that this single continuous distribution pattern of GLI1 mRNA expression technically puts almost all GBM patients in a single group rather than discrete high- or low-clusters in terms of Hh-pathway activity. That is suggestive of therapies with Hh-pathway inhibitor drugs in this malignancy without a need for further stratification of patients on the basis of relative levels of Hh-pathway activity among them.

  4. Medicaid Issue Briefs

    Data.gov (United States)

    U.S. Department of Health & Human Services — MS, in collaboration with Mathematica, has started the MAX Medicaid policy issue brief series, which highlights the essential role MAX data can play in analyzing...

  5. Duration distributions for gamma-ray bursts registered in various experiments since VENERA11/KONUS up to Fermi/GBM.

    Science.gov (United States)

    Arkhangelskaja, I. V.

    2016-02-01

    Gamma-ray bursts duration distributions properties for events registered by experiments CGRO/BATSE, VENERA11/KONUS, VENERA12/KONUS, Swift/BAT, GRANAT/PHEBUS, Suzaku/WAM, RHESSI and Fermi/GBM are considered. GRBs observed since 1967 and now several thousands of events were listed in more than 30 catalogues. Gamma-ray bursts duration distribution was the first analysed using data of BATSE instrument onboard the CGRO. The GRBs duration distribution analysis had shown the existence of two bursts classes: long and short separated by t90 = 2 s. But results of similar distributions for bursts observed by other detectors have shown shifting of boundary between short and long events from value of 2 s. For example, Swift/BAT GRBs subset analysis gives the value of ∼1 s for this separator point. Moreover, t90 has dependence from instrument registered this burst - it is function of detector sensitivity threshold and operation energy band. For instance, the duration of GRB060418 burst t90 is ∼52 s according to Swift/BAT data and only 36 s according to RHESSI data. Therefore, the type of GGB (whether it short or long) should be defined only taking into account distinctive features of instrument detected this event. Also attributes of third intermediate GRBs subgroup appearance in events subsets for various detectors are discussed. Firstly this subgroup was found some years ago in BATSE GRB duration and duration-hardness distributions.

  6. The Fermi-GBM X-ray burst monitor: thermonuclear bursts from 4U 0614+09

    CERN Document Server

    Linares, M; Jenke, P; van der Horst, A J; Camero-Arranz, A; Kouveliotou, C; Chakrabarty, D; Beklen, E; Bhat, P N; Briggs, M S; Finger, M; Paciesas, W; Preece, R; von Kienlin, A; Wilson-Hodge, C A

    2012-01-01

    Thermonuclear bursts from slowly accreting neutron stars (NSs) have proven difficult to detect, yet they are potential probes of the thermal properties of the neutron star interior. During the first year of a systematic all-sky search for X-ray bursts using the Gamma-ray Burst Monitor (GBM) aboard the Fermi Gamma-ray Space Telescope we have detected 15 thermonuclear bursts from the NS low-mass X-ray binary 4U 0614+09, when it was accreting at nearly 1% of the Eddington limit. We measured an average burst recurrence time of 12+/-3 d (68% confidence interval) between March 2010 and March 2011, classified all bursts as normal duration bursts and placed a lower limit on the recurrence time of long/intermediate bursts of 62 d (95% confidence level). We discuss how observations of thermonuclear bursts in the hard X-ray band compare to pointed soft X-ray observations, and quantify such bandpass effects on measurements of burst radiated energy and duration. We put our results for 4U 0614+09 in the context of other bu...

  7. Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress.

    Directory of Open Access Journals (Sweden)

    Yajuan Li

    Full Text Available Previously we have shown that kallikreins (klks play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs as vehicles to deliver klks into the injured kidneys and have measured their therapeutic effect on experimental antibody induced nephritis and lupus nephritis. Human KLK-1 (hKLK1 gene was transduced into murine MSCs using a retroviral vector to generate a stable cell line, hKLK1-MSC, expressing high levels of hKLK1. 129/svj mice subjected to anti-GBM induced nephritis were transplanted with 10(6 hKLK1-MSCs and hKLK1 expression was confirmed in the kidneys. Compared with vector-MSCs injected mice, the hKLK1-MSCs treated mice showed significantly reduced proteinuria, blood urea nitrogen (BUN and ameliorated renal pathology. Using the same strategy, we treated lupus-prone B6.Sle1.Sle3 bicongenic mice with hKLK1-MSCs and demonstrated that hKLK1-MSCs delivery also attenuated lupus nephritis. Mechanistically, hKLK1-MSCs reduced macrophage and T-lymphocyte infiltration into the kidney by suppressing the expression of inflammation cytokines. Moreover, hKLK1 transduced MSCs were more resistant to oxidative stress-induced apoptosis. These findings advance genetically modified MSCs as potential gene delivery tools for targeting therapeutic agents to the kidneys in order to modulate inflammation and oxidative stress in lupus nephritis.

  8. Intravitreal bevacizumab (avastin for circumscribed choroidal hemangioma

    Directory of Open Access Journals (Sweden)

    Subrata Mandal

    2011-01-01

    Full Text Available Circumscribed choroidal hemangiomas are rare ophthalmic entities that cause diminution in vision due to accumulation of subretinal and/or intraretinal fluid in the macular area. Various treatment options ranging from conventional laser to photodynamic therapy have been employed to destroy the tumor and reduce the exudation; however, either the inability to penetrate through the exudative fluid or the collateral retinal damage induced by these treatment modalities make them unsuitable for lesions within the macula. We evaluated the role of intravitreal bevacizumab, a pan-vascular endothelial growth factor (VEGF inhibitor, in reducing the sub- and intraretinal fluid in three patients with circumscribed choroidal hemangiomas. All the patients had complete resolution of the serous retinal detachment that was maintained till at least 12 months after the first injection. Intravitreal bevacizumab may be used in combination with thermal laser or photodynamic therapy in treating circumscribed choroidal hemangiomas with subretinal fluid.

  9. Failure of two subsequent renal grafts by anti-GBM glomerulonephritis in Alport's syndrome: case report and review of the literature.

    Science.gov (United States)

    Goldman, M; Depierreux, M; De Pauw, L; Vereerstraeten, P; Kinnaert, P; Noël, L H; Grünfeld, J P; Toussaint, C

    1990-07-01

    We describe a patient with Alport's syndrome who developed severe crescentic glomerulonephritis after each of two successive transplantations, leading to accelerated graft failure on both occasions. This complication occurred in the 7th postoperative month for the first transplant and in the immediate postoperative period for the second. Immunopathological studies of the second transplant demonstrated that the glomerular lesions were mediated by antiglomerular basement membrane (GBM) antibodies displaying the same pattern of reactivity as the MCA-Pl monoclonal antibody directed against the Good-pasture antigen. This observation indicates that the anti-GBM immunization induced by renal transplantation in some patients with Alport's syndrome may be responsible for recurrent graft failure. PMID:2206225

  10. Earth Occultation Imaging Applied to BATSE -- Application to a Combined BATSE-GBM Survey of the Hard X-Ray Sky

    CERN Document Server

    Zhang, Yuan; Case, Gary; Ling, James; Wheaton, William

    2013-01-01

    A combined BATSE-GBM hard X-ray catalog is presented based on Earth Occultation Imaging applied to a reanalysis of BATSE data. An imaging approach has been developed for the reanalysis of Earth Occultation analysis of BATSE data. The standard occultation analysis depends on a predetermined catalog of potential sources, so that a real source not present in the catalog may induce systematic errors when source counts associated with an uncatalogued source are incorrectly attributed to catalog sources. The goal of the imaging analysis is to find a complete set of hard X-ray sources, including sources not in the original BATSE occultation catalog. Using the imaging technique, we have identified 15 known sources and 17 unidentified sources and added them to the BATSE occultation catalog. The resulting expanded BATSE catalog of sources observed during 1991-2000 is compared to the ongoing GBM survey.

  11. Fermi Guest Investigator Program Cycle 2 Project Final Report Albedo Polarimetry of Gamma-Ray Bursts and Solar Flares with GBM

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Richard Marc [Los Alamos National Laboratory

    2012-08-27

    Several key properties of GRBs remain poorly understood and are difficult or even impossible to infer with the information currently being collected. Polarization measurements will probe the precise nature of the central engine. For solar flares, high-energy polarization measurements are expected to be useful in determining the beaming (or directivity) of solar flare electrons - a quantity that may provide important clues about electron acceleration and transport. We propose to investigate the viability of using the Fermi Gamma-ray Burst Monitor (GBM) to measure the polarization of GRBs and solar flares using the albedo photon flux. This approach was previously developed for use with BATSE data. We will conduct a careful study of this technique using a modified version of the GRESS simulation tools developed by the GBM team.

  12. Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: A multi-center study

    OpenAIRE

    Pope, WB; Qiao, XJ; Kim, HJ; Lai, A.; Nghiemphu, P; Xue, X.; Ellingson, BM; Schiff, D.; Aregawi, D; Cha, S; Puduvalli, VK; Wu, J.; Yung, WKA; Young, GS; Vredenburgh, J

    2012-01-01

    We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patients with recurrent glioblastoma multiforme (GBM) from the multi-center BRAIN study. Available MRI's from patients enrolled in the BRAIN study (n = 97) were examined by generating ADC histograms from areas of enhancing tumor on T1 weighted post-contrast images fitted to a two normal distribution mixtu...

  13. Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase

    OpenAIRE

    Paixão-Cavalcante, Danielle; Hanson, Steven; Botto, Marina; Cook, H. Terence; Pickering, Matthew C.

    2009-01-01

    Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh −/−) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with features of DDD, a lesion dependent on C3 activation. In order to understand the role of CFH in preventing renal damage associated with the dysregulation of the alternative pathway we administered p...

  14. Epidermal growth factor receptor (EGFR mutation status and Rad51 determine the response of glioblastoma (GBM to multimodality therapy with cetuximab, temozolomide and radiation

    Directory of Open Access Journals (Sweden)

    Phyllis Rachelle Wachsberger

    2013-02-01

    Full Text Available Purpose: EGFR amplification and mutation (i.e., EGFRvIII are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulates response to multimodality treatment with cetuximab, an anti-EGFR inhibitor, the chemotherapeutic agent, temozolamide (TMZ and radiation therapy (RT Methods and Materials: In vitro and in vivo experiments were performed on two isogenic U87 GBM cell lines: one overexpressing wildtype EGFR (U87wtEGFR and the other overexpressing EGFRvIII (U87EGFRvIII. Results: Xenografts harboring EGFRvIII were more sensitive to TMZ alone and TMZ in combination with RT and/or cetuximab than xenografts expressing wtEGFR. In vitro experiments demonstrated that U87EGFRvIII-expressing tumors appear to harbor defective DNA homologous recombination repair in the form of Rad51 processing, Conclusions: The difference in sensitivity between EGFR-expressing and EGFRvIII-expressing tumors to combined modality treatment may help in the future tailoring of GBM therapy to subsets of patients expressing more or less of the EGFR mutant.

  15. Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome

    Directory of Open Access Journals (Sweden)

    Kistler Thomas

    2011-06-01

    Full Text Available Abstract Background Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients presenting as anti-GBM antibody positive pulmonary-renal syndrome or rapidly progressive glomerulonephritis are also tested positive for anti-neutrophil cytoplasmic antibodies (ANCA. Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable. Case Presentation We report a patient with such dual positivity, who presented with pulmonary hemorrhage, crescentic glomerulonephritis and membranous nephropathy. Plasmapheresis in combination with immunosuppresive therapy led to a rapid remission but the disease relapsed after two years. The serum of the patient was tested positive for antibodies to human lysosomal membrane protein 2 (hLAMP2, a novel autoantigen in patients with active small-vessel vasculitis (SVV. The anti-hLAMP2 antibody levels correlated positively with clinical disease activity in this patient. Conclusion We hypothesize that this antibody may indicate a clinical course similar to ANCA-associated vasculitis in double-positive patients. However, this needs to be confirmed on comprehensive patient cohorts.

  16. Informatics: A Brief Survey.

    Science.gov (United States)

    He, Shaoyi

    2003-01-01

    Provides a brief survey of informatics, defined as the application of information technology to various fields, with respect to its historical background, disciplinary identity, fundamental aspects, applications, and challenges. Highlights include biological, clinical, dental, environmental, geomatics, health, legal, management, medical, museum,…

  17. Research in Brief.

    Science.gov (United States)

    Journalism Quarterly, 1984

    1984-01-01

    Brief research reports discuss Latin America as seen on United States network television; television news coverage of federal regulatory agencies; community perceptions of media impressions; active television viewing and cultivation hypothesis; the impact of cable on traditional television news viewing; George Kibbe Turner; advertising; and…

  18. Research in Brief.

    Science.gov (United States)

    Journalism Quarterly, 1982

    1982-01-01

    Offers brief descriptions of research concerning (1) media bias toward business, (2) foreign affairs coverage in elite and mass periodicals, (3) how emphasis on people affects coverage of crime, (4) antisocial and prosocial behavior on prime-time television, (5) network news coverage of Iran, and (6) magazines' reporting on insects. (FL)

  19. Issue Brief on Diversity

    Science.gov (United States)

    Division on Developmental Disabilities, Council for Exceptional Children (NJ1), 2013

    2013-01-01

    During the past year, the Diversity Committee of the Division of Developmental Disabilities (DDD) Board worked with the Board and the Issues Committee Chair to develop an issue brief addressing diversity, its impact on the membership and the wider community that is served by the work of DDD, resulting in recommendations that will influence policy…

  20. Cybernetics of Brief Family Therapy.

    Science.gov (United States)

    Keeney, Bradford P.; Ross, Jeffrey M.

    1983-01-01

    Presents a cybernetic view of brief family therapy. Includes a historical discussion of the key ideas underlying brief family therapy, a cybernetic model of therapeutic change, and a clinical case for exemplification. (Author/JAC)

  1. Inclusive Briefing and User Involvement

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2011-01-01

    Briefing is not just about specifying needs as requirements but also about evaluating how well design proposals fulfil needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the preproject stage to create a basis for the project decision and can include...

  2. Fermi GBM Trigger Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — Fermi is a powerful space observatory that will open a wide window on the universe. Gamma rays are the highest-energy form of light, and the gamma-ray sky is...

  3. My brief history

    CERN Document Server

    Hawking, Stephen

    2013-01-01

    My Brief History recounts Stephen Hawking’s improbable journey, from his postwar London boyhood to his years of international acclaim and celebrity. Lavishly illustrated with rarely seen photographs, this concise, witty, and candid account introduces readers to a Hawking rarely glimpsed in previous books: the inquisitive schoolboy whose classmates nicknamed him Einstein; the jokester who once placed a bet with a colleague over the existence of a particular black hole; and the young husband and father struggling to gain a foothold in the world of physics and cosmology. Writing with characteristic humility and humor, Hawking opens up about the challenges that confronted him following his diagnosis of ALS at age twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time—one of the iconic books of the twentieth century.

  4. Strategic forces briefing

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  5. Characterization of biological features of a rat F98 GBM model: A PET-MRI study with [18F]FAZA and [18F]FDG

    International Nuclear Information System (INIS)

    Introduction: The prognosis of malignant gliomas remains largely unsatisfactory for the intrinsic characteristics of the pathology and for the delayed diagnosis. Multimodal imaging based on PET and MRI may assess the dynamics of disease onset and progression allowing the validation of preclinical models of glioblastoma multiforme (GBM). The aim of this study was the characterization of a syngeneic rat model of GBM using combined in vivo imaging and immunohistochemistry. Methods: Four groups of Fischer rats were implanted in a subcortical region with increasing concentration of rat glioma F98 cells and weekly monitored with Gd-MR, [18F]FDG- and [18F]FAZA-PET starting one week after surgery. Different targets were evaluated on post mortem brain specimens using immunohistochemistry: VEGF, GFAP, HIF-1α, Ki-67 and nestin. Results: Imaging results indicated that tumor onset but not progression was related to the number of F98 cells. Hypoxic regions identified with [18F]FAZA and high-glucose metabolism regions recognized with [18F]FDG were located respectively in the core and in external areas of the tumor, with partial overlap and remodeling during disease progression. Histological and immunohistochemical analysis confirmed PET/MRI results and revealed that our model resumes biological characteristics of human GBM. IHC and PET studies showed that necrotic regions, defined on the basis of [18F]FDG uptake reduction, may include hypoxic clusters of vital tumor tissue identified with [18F]FAZA. This last information is particularly relevant for the identification of the target volume during image-guided radiotherapy. Conclusions: In conclusion, the combined use of PET and MRI allows in vivo monitoring of the biological modification of F98 lesions during tumor progression

  6. Brief introduction to relativity

    International Nuclear Information System (INIS)

    A brief, but rigorous and uncondensed, introduction to special relativity is given. The reader is assumed to be familiar with coordinate transformations in general and to have a reasonable grasp of advanced calculus and vector analysis. The subject is presented under the following topics: hypotheses underlying the Lorentz transformation, kinematics and algebraic properties of the Lorentz transformation, vectors and tensors in relativity, the electromagnetic field and Maxwell's equations, the dynamics of a particle and the Lorentz force equation, photons and relativistic optics, and applications of relativistic optics. 3 figures

  7. Sustainable Markets Investment Briefings: Overview

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the first of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 1 provides a general overview of key issues.

  8. Study of luminosity and spin-up relation in X-ray binary pulsars with long-term monitoring by MAXI/GSC and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Nakajima, Motoki; Yamaoka, Kazutaka

    2015-01-01

    We study the relation between luminosity and spin-period change in X-ray binary pulsars using long-term light curve obtained by the MAXI/GSC all-sky survey and pulse period data from the Fermi/GBM pulsar project. X-ray binaries, consisting of a highly magnetized neutron star and a stellar companion, originate X-ray emission according to the energy of the accretion matter onto the neutron star. The accretion matter also transfers the angular momentum at the Alfven radius, and then spin up the neutron star. Therefore, the X-ray luminosity and the spin-up rate are supposed to be well correlated. We analyzed the luminosity and period-change relation using the data taken by continuous monitoring of MAXI/GSC and Fermi/GBM for Be/X-ray binaries, GX 304$-$1, A 0535$+$26, GRO J1008$-$57, KS 1947$+$300, and 2S 1417$-$624, which occurred large outbursts in the last four years. We discuss the results comparing the obtained observed relation with that of the theoretical model by Ghosh \\& Lamb (1979).

  9. 17 CFR 9.23 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 9.23 Section... Appeals § 9.23 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the appeal brief, the exchange must file with the Commission an answering brief. (b) Contents...

  10. 24 CFR 1720.615 - Reply brief.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Reply brief. 1720.615 Section 1720... Proceedings Appeals § 1720.615 Reply brief. A brief in reply to an answering brief, limited to rebuttal of matters in the answering brief, may be filed and served by a party within 7 days after receipt of...

  11. Brief encounter networks

    CERN Document Server

    Kostakos, Vassilis; Penn, Alan

    2007-01-01

    Many complex human and natural phenomena can usefully be represented as networks describing the relationships between individuals. While these relationships are typically intermittent, previous research has used network representations that aggregate the relationships at discrete intervals. However, such an aggregation discards important temporal information, thus inhibiting our understanding of the networks dynamic behaviour and evolution. We have recorded patterns of human urban encounter using Bluetooth technology thus retaining the temporal properties of this network. Here we show how this temporal information influences the structural properties of the network. We show that the temporal properties of human urban encounter are scale-free, leading to an overwhelming proportion of brief encounters between individuals. While previous research has shown preferential attachment to result in scale-free connectivity in aggregated network data, we found that scale-free connectivity results from the temporal prope...

  12. Galileo Mission Science Briefing

    Science.gov (United States)

    1989-07-01

    The first of two tapes of the Galileo Mission Science press briefing is presented. The panel is moderated by George Diller from the Kennedy Space Center (KSC) Public Affairs Office. The participants are John Conway, the director of Payload and operations at Kennedy; Donald E. Williams, Commander of STS-43, the shuttle mission which will launch the Galileo mission; John Casani, the Deputy Assistant Director of Flight Projects at the Jet Propulsion Lab (JPL); Dick Spehalski, Galileo Project Manager at JPL; and Terrence Johnson, Galileo Project Scientist at JPL. The briefing begins with an announcement of the arrival of the Galileo Orbiter at KSC. The required steps prior to the launch are discussed. The mission trajectory and gravity assists from planetary and solar flybys are reviewed. Detailed designs of the orbiter are shown. The distance that Galileo will travel from the sun precludes the use of solar energy for heat. Therefore Radioisotope heater units are used to keep the equipment at operational temperature. A video of the arrival of the spacecraft at KSC and final tests and preparations is shown. Some of the many science goals of the mission are reviewed. Another video showing an overview of the Galileo mission is presented. During the question and answer period, the issue of the use of plutonium on the mission is broached, which engenders a review of the testing methods used to ensure the safety of the capsules containing the hazardous substance. This video has actual shots of the orbiter, as it is undergoing the final preparations and tests for the mission.

  13. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    Directory of Open Access Journals (Sweden)

    Garcia Juan L

    2010-08-01

    Full Text Available Abstract Background Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Methods Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Results Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders. Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups

  14. Innovative Hypofractionated Stereotactic Regimen Achieves Excellent Local Control with No Radiation Necrosis: Promising Results in the Management of Patients with Small Recurrent Inoperable GBM.

    Science.gov (United States)

    Jia, Angela; Pannullo, Susan C; Minkowitz, Shlomo; Taube, Shoshana; Chang, Jenghwa; Parashar, Bhupesh; Christos, Paul; Wernicke, A Gabriella

    2016-01-01

    Management of recurrent glioblastoma multiforme (GBM) remains a challenge. Several institutions reported that a single fraction of ≥ 20 Gy for small tumor burden results in excellent local control; however, this is at the expense of a high incidence of radiation necrosis (RN). Therefore, we developed a hypofractionation pattern of 33 Gy/3 fractions, which is a radiobiological equivalent of 20 Gy, with the aim to lower the incidence of RN. We reviewed records of 21 patients with recurrent GBM treated with hypofractionated stereotactic radiation therapy (HFSRT) to their 22 respective lesions. Sixty Gy fractioned external beam radiotherapy was performed as first-line treatment. Median time from primary irradiation to HFSRT was 9.6 months (range: 3.1 - 68.1 months). In HFSRT, a median dose of 33 Gy in 11 Gy fractions was delivered to the 80% isodose line that encompassed the target volume. The median tumor volume was 1.07 cm3 (range: 0.11 - 16.64 cm3). The median follow-up time after HFSRT was 9.3 months (range: 1.7 - 33.6 months). Twenty-one of 23 lesions treated (91.3%) achieved local control while 2/23 (8.7%) progressed. Median time to progression outside of the treated site was 5.2 months (range: 2.2 - 9.6 months). Progression was treated with salvage chemotherapy. Five of 21 patients (23.8%) were alive at the end of this follow-up; two patients remain disease-free. The remaining 16/21 patients (76.2%) died of disease. Treatment was well tolerated by all patients with no acute CTC/RTOG > Grade 2. There was 0% incidence of RN. A prospective trial will be underway to validate these promising results. PMID:27096136

  15. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined all- and auto-immune tumor reactivity

    NARCIS (Netherlands)

    Schijns, V.E.J.C.; Pretto, C.; Devillers, L.; Pierre, D.; Hofman, F.M.; Chen, T.C.; Mespouille, P.; Hantos, P.; Glorieux, P.; Bota, D.A.; Stathopolous, A.

    2015-01-01

    Glioblastoma multiforme (GBM) patients have a poor prognosis. After tumor recurrence statistics suggestan imminent death within 1–4.5 months. Supportive preclinical data, from a rat model, provided therational for a prototype clinical vaccine preparation, named Gliovac (or ERC 1671) composed of auto

  16. Neuroophthalmology A brief Vademecum

    International Nuclear Information System (INIS)

    The stunning, intricate interaction between the visual, vestibular and optomotor systems--each a miracle on its own--ensures maintenance of orientation in space as well as visual recognition and target selection despite a host of sensory conflicts and adversary disturbances. Their main goals are to keep a target of interest on the fovea by either maintaining or shifting the direction of gaze in order to produce an accurate internal representation of the visual surroundings, in particular the selected target, and to continuously mirror the spatial relationship between these various visual elements and the self. Not surprising, the implementation of this host of elaborate neural networks encompasses almost every part of the brain, including the brainstem, cerebellum, extrapyramidal system and many areas of the cerebral cortex. Thus far, these systems are among the best investigated in brain research; and enormous knowledge was amassed over the last century employing a variety of techniques, including single cell recordings, eye movement studies, functional imaging and neuropsychological observations. In addition, this prolific line of research has enlightened many fundamental principles of neural and neuronal processing, which have subsequently enriched other fields of brain research as well as computational neuroscience, e.g. the discovery of receptive fields, which have now become a ubiquitous concept in many other areas of neurophysiology. This (improperly) brief, fractional and undoubtedly biased Vademecum is meant to accompany the reader into this marvellous field of neurophysiology and neurology. In particular, it stresses the clinical application of its functional neuroanatomy at the bedside, which, in many respects, is superior to other means of investigating a patient

  17. 24 CFR 1720.610 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Answering brief. 1720.610 Section... Proceedings Appeals § 1720.610 Answering brief. Within 20 days after service of an appeal brief upon a party, such party may file an answering brief conforming to the requirements of § 1720.620....

  18. 17 CFR 171.26 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 171.26... Denial and Registration Actions § 171.26 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the apeal brief, the National Futures Association shall file with...

  19. 37 CFR 41.71 - Rebuttal brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Rebuttal brief. 41.71 Section... Rebuttal brief. (a) Within one month of the examiner's answer, any appellant may once file a rebuttal brief. (b)(1) The rebuttal brief of the owner may be directed to the examiner's answer and/or any...

  20. Spanish Language Briefs for Parents, 1995.

    Science.gov (United States)

    ERIC Clearinghouse on Rural Education and Small Schools, Charleston, WV.

    This packet contains six briefs developed specifically for Spanish-speaking parents of Mexican origin, and English translations of the briefs. In plain language, these briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. Titles of the briefs are (1) "Apoyando el…

  1. Electricity Storage. Technology Brief

    Energy Technology Data Exchange (ETDEWEB)

    Simbolotti, G. [Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Rome (Italy); Kempener, R. [International Renewable Energy Agency IRENA, Bonn (Germany)

    2012-04-15

    Electricity storage is a key technology for electricity systems with a high share of renewables as it allows electricity to be generated when renewable sources (i.e. wind, sunlight) are available and to be consumed on demand. It is expected that the increasing price of fossil fuels and peak-load electricity and the growing share of renewables will result in electricity storage to grow rapidly and become more cost effective. However, electricity storage is technically challenging because electricity can only be stored after conversion into other forms of energy, and this involves expensive equipment and energy losses. At present, the only commercial storage option is pumped hydro power where surplus electricity (e.g. electricity produced overnight by base-load coal or nuclear power) is used to pump water from a lower to an upper reservoir. The stored energy is then used to produce hydropower during daily high-demand periods. Pumped hydro plants are large-scale storage systems with a typical efficiency between 70% and 80%, which means that a quarter of the energy is lost in the process. Other storage technologies with different characteristics (i.e. storage process and capacity, conversion back to electricity and response to power demand, energy losses and costs) are currently in demonstration or pre-commercial stages and discussed in this brief report: Compressed air energy storage (CAES) systems, Flywheels; Electrical batteries; Supercapacitors; Superconducting magnetic storage; and Thermal energy storage. No single electricity storage technology scores high in all dimensions. The technology of choice often depends on the size of the system, the specific service, the electricity sources and the marginal cost of peak electricity. Pumped hydro currently accounts for 95% of the global storage capacity and still offers a considerable expansion potential but does not suit residential or small-size applications. CAES expansion is limited due to the lack of suitable

  2. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    International Nuclear Information System (INIS)

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×107, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 109 cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work is supported

  3. SU-D-BRB-06: Treating Glioblastoma Multiforme (GBM) as a Chronic Disease: Implication of Temporal-Spatial Dose Fractionation Optimization Including Cancer Stem Cell Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Yu, V; Nguyen, D; Pajonk, F; Kaprealian, T; Kupelian, P; Steinberg, M; Low, D; Sheng, K [Department of Radiation Oncology, UCLA, Los Angeles, CA (United States)

    2015-06-15

    Purpose: To explore the feasibility of improving GBM treatment outcome with temporal-spatial dose optimization of an ordinary differential equation (ODE) that models the differentiation and distinct radiosensitivity between cancer stem cells (CSC) and differentiated cancer cells (DCC). Methods: The ODE was formulated into a non-convex optimization problem with the objective to minimize remaining total cancer cells 500 days from the onset of radiotherapy when the total cancer cell number was 3.5×10{sup 7}, while maintaining normal tissue biological effective dose (BED) of 100Gy resulted from standard prescription of 2Gyx30. Assuming spatially separated CSC and DCC, optimization was also performed to explore the potential benefit from dose-painting the two compartments. Dose escalation to a sub-cell-population in the GTV was also examined assuming that a 2 cm margin around the GTV allows sufficient dose drop-off to 100Gy BED. The recurrence time was determined as the time at which the total cancer cell number regrows to 10{sup 9} cells. Results: The recurrence time with variable fractional doses administered once per week, bi-week and month for one year were found to be 615, 593 and 570 days, superior to the standard-prescription recurrence time of 418 days. The optimal dose-fraction size progression for both uniform and dose-painting to the tumor is low and relatively constant in the beginning and gradually increases to more aggressive fractions at end of the treatment course. Dose escalation to BED of 200Gy to the whole tumor alongside with protracted weekly treatment was found to further delay recurrence to 733 days. Dose-painting of 200 and 500Gy BED to CSC on a year-long weekly schedule further extended recurrence to 736 and 1076 days, respectively. Conclusion: GBM treatment outcome can possibly be improved with a chronic treatment approach. Further dose escalation to the entire tumor or CSC targeted killing is needed to achieve total tumor control. This work

  4. Beacons In Brief. P/PV In Brief. Issue 2

    Science.gov (United States)

    Blank, Susan; Farley, Chelsea

    2004-01-01

    This second issue in P/PV's "In Brief" series focuses on the San Francisco Beacon Initiative and P/PV's recently released evaluation results. The Beacon Initiative established after-school programs in eight public schools in low-income San Francisco neighborhoods. P/PV's 36-month evaluation examined key developmental and academic outcomes.…

  5. Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.

    Science.gov (United States)

    Liao, Chia-Leng; Chen, Chien-Min; Chang, Yan-Zin; Liu, Guang-Yaw; Hung, Hui-Chih; Hsieh, Tung-Ying; Lin, Chih-Li

    2014-10-29

    Pine needle extracts of Pinus morrisonicola (Hayata) are commonly used as a functional health beverage. However, it remains unclear what the mechanism is underlying the antitumor activity of pine needle extract. The aims of present study were to investigate the anti-glioblastoma effects of pine needle extracts as well as its bioactive compounds. From three different solvent extracts of pine needles, the water extract displayed the strongest cytotoxicity effects on GBM8901 glioblastoma cells. The isolated compounds were identified as pinocembrin, chrysin, and tiliroside. Chrysin was the most active ingredient of pine needle extract for the induction of apoptosis and suppression of migration and invasion. It also markedly inhibited temozolomide (TMZ)-induced autophagy and O(6)-methylguanine-DNA methyltransferase (MGMT) expression. Because both autophagy and MGMT overexpression have been implicated to TMZ-induced drug resistance in glioblastoma, our results showed that pine needle extract and chrysin may serve as a potential anticancer agent against glioblastoma, especially with regard to sensitizing glioblastoma cells resistant to TMZ.

  6. Public Health England Briefing Papers

    OpenAIRE

    Public Health England

    2013-01-01

    -Social and economic inequalities in diet and physical activity - Obesity and disability - adults - Obesity and alcohol - an overview - A simple guide to classifying body mass index in children - Knowledge and attitudes towards healthy eating and physical activity - Brief intervetions for weight management - Data sources:environmental influences on physical activity and diet - Measuring diet and physical activity in weight management interventions - Obesity and Mental ...

  7. Brief Psychotherapy: The Multimodal Model.

    Science.gov (United States)

    Lazarus, Arnold A.

    1989-01-01

    Outlines tenets of multimodal therapy (MMT) and argues for its cost-effective yet comprehensive value as a brief psychotherapy model. Describes MMT as an integrated, seven-modality model of personality and provides clinical examples of its use. Argues that MMT approach will be an important future alternative to more expensive, time-consuming, and…

  8. Childhood Obesity. Special Reference Briefs.

    Science.gov (United States)

    Winick, Myron

    This reference brief deals with the problem of childhood obesity and how it can lead to obesity in the adult. Eighty-four abstracts are presented of studies on the identification, prevention, and treatment of obesity in children, focusing on diet and psychological attitudes. Subjects of the studies were children ranging in age from infancy through…

  9. Humans and Robots. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses human movement and robotic human movement simulators. The activity for students in grades 5-12 provides a history of robotic movement and includes making an End Effector for the robotic arms used on the Space Shuttle and the International Space Station (ISS). (MVL)

  10. BRIEFING ABOUT SIMCORB BUSINESS PLAN

    Science.gov (United States)

    The SIMCorB Business Plan was discussed at the ORD Infrastructure Meeting held on July 17, 2000 in Washington, D.C.The briefing explained the purpose of the Plan as a vehicle to provide a road map to attain the ORD science IM vision. The road map includes defined milestones, bu...

  11. Brief Counseling with Hispanic American College Students.

    Science.gov (United States)

    Littrell, John M.; Cruz, Jeannette

    1998-01-01

    Hispanic-American college students (N=16) met with a Puerto-Rican counselor for two brief counseling sessions. Brief counseling was a viable and effective approach in helping the students reach their goals. Examined types of student concerns about, and student perceptions of, brief counseling. (Author)

  12. 17 CFR 171.25 - Appeal brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 171.25 Section... Denial and Registration Actions § 171.25 Appeal brief. (a) Time to file. Any person who has filed a... appeal brief with the Proceedings Clerk within thirty days after service of the record by the...

  13. 17 CFR 9.22 - Appeal brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Appeal brief. 9.22 Section 9... Appeals § 9.22 Appeal brief. (a) Time to file. Any person who has filed a notice of appeal in accordance with the provisions of § 9.20 must perfect the appeal by filing an appeal brief with the...

  14. 37 CFR 41.41 - Reply brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Reply brief. 41.41 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Ex Parte Appeals § 41.41 Reply brief... file a reply brief to an examiner's answer within two months from the date of the examiner's answer....

  15. 37 CFR 41.37 - Appeal brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Appeal brief. 41.37 Section... brief. Link to an amendment published at 73 FR 32974, June 10, 2008. Per final rule published at 73 FR...) Appellant must file a brief under this section within two months from the date of filing the notice...

  16. 37 CFR 41.68 - Respondent's brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Respondent's brief. 41.68... Respondent's brief. (a)(1) Respondent(s) in an appeal may once, within the time limit for filing set forth in... title. (2) The brief must be signed by the party, or the party's duly authorized attorney or agent,...

  17. 37 CFR 41.67 - Appellant's brief.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Appellant's brief. 41.67... Appellant's brief. (a)(1) Appellant(s) may once, within time limits for filing set forth in § 41.66, file a... title. (2) The brief must be signed by the appellant, or the appellant's duly authorized attorney...

  18. A Brief History of Context

    CERN Document Server

    Wan, Kaiyu

    2009-01-01

    Context is a rich concept and is an elusive concept to define. The concept of context has been studied by philosophers, linguists, psychologists, and recently by computer scientists. Within each research community the term context was interpreted in a certain way that is well-suited for their goals, however no attempt was made to define context. In many areas of research in computer science, notably on web-based services, human-computer interaction (HCI), ubiquitous computing applications, and context-aware systems there is a need to provide a formal operational definition of context. In this brief survey an account of the early work on context, as well as the recent work on many working definitions of context, context modeling, and a formalization of context are given. An attempt is made to unify the different context models within the formalization. A brief commentary on the usefulness of the formalization in the development of context-aware and dependable systems is included.

  19. Brief Psychotherapy in Family Practice

    OpenAIRE

    MacDonald, Peter J.; Brown, Alan

    1986-01-01

    A large number of patients with psychosocial or psychiatric disorders present to family physicians, and the family physician needs a model of psychotherapy with which to cope with their problems. A model of brief psychotherapy is presented which is time limited, goal directed and easy to learn. It consists of four facets drawn from established areas of psychotherapy: characteristics of the therapist; characteristics of the patient; Eriksonian developmental stages; and the process of therapy a...

  20. A brief history of videogames

    OpenAIRE

    Simone Belli; Cristian López

    2008-01-01

    The following text contains a brief journey through a short and yet intense adventure, the history of videogames. Since its beginnings in the 1950's decade to the present time, videogames have progressively changed from a hobby for ingeneering studens to the most powerfull leisure industry. In order to gain a better understanding of this phenomenon it is necessary to look over the path of its transformation from a retrospecive point of view. Such a look has necessarily t...

  1. The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.

    Directory of Open Access Journals (Sweden)

    Janice A Royds

    Full Text Available Prognostic markers for glioblastoma multiforme (GBM are important for patient management. Recent advances have identified prognostic markers for GBMs that use telomerase or the alternative lengthening of telomeres (ALT mechanism for telomere maintenance. Approximately 40% of GBMs have no defined telomere maintenance mechanism (NDTMM, with a mixed survival for affected individuals. This study examined genetic variants in the cyclin-dependent kinase inhibitor 2A (CDKN2A gene that encodes the p16(INK4a and p14(ARF tumor suppressors, and the isocitrate dehydrogenase 1 (IDH1 gene as potential markers of survival for 40 individuals with NDTMM GBMs (telomerase negative and ALT negative by standard assays, 50 individuals with telomerase, and 17 individuals with ALT positive tumors. The analysis of CDKN2A showed NDTMM GBMs had an increased minor allele frequency for the C500G (rs11515 polymorphism compared to those with telomerase and ALT positive GBMs (p = 0.002. Patients with the G500 allele had reduced survival that was independent of age, extent of surgery, and treatment. In the NDTMM group G500 allele carriers had increased loss of CDKN2A gene dosage compared to C500 homozygotes. An analysis of IDH1 mutations showed the R132H mutation was associated with ALT positive tumors, and was largely absent in NDTMM and telomerase positive tumors. In the ALT positive tumors cohort, IDH1 mutations were associated with a younger age for the affected individual. In conclusion, the G500 CDKN2A allele was associated with NDTMM GBMs from older individuals with poorer survival. Mutations in IDH1 were not associated with NDTMM GBMs, and instead were a marker for ALT positive tumors in younger individuals.

  2. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Simpler forex rules According to the State Administration of Foreign Exchange,China began a trial program for simplifying the procedures for passing foreign currencies between banks and companies in the trading of goods.Effective from December 1,the new rules don’t require verification for information about prepayments for goods,payment cancellations or delays.

  3. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    RMB trade The Bank of China has opened trading in the yuan currency to U.S.customers. The bank’s New York Branch now lets companies and individuals buy and sell the yuan through accounts with its U.S. branches,although U.S.businesses and individuals can also trade the currency through Western banks.The bank said it offers yuan savings,demand deposit and time deposit accounts to business customers in New York and Los Angeles. A savings account requires a minimum balance of the equivalent of $5,000.

  4. BRIEFS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    EIGHT FIELDS TO BE DEVELOPED Eight key fields to be preferentially developed in metallurgical industry are rare earth materials, composite materials, magnesium, aluminum and titanium alloy materials, high performance and low cost iron and steel materials, new dressing equipment and reagent, surface coated and plated materials, high efficient and safe production of coal and new architectural system. Key fields to realize industrialization are high purity rare earth oxides, high performance rare earth perm...

  5. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    3 More competitive According to the Global Competitiveness Report 2011-12,China’s competitiveness ranking rose from 27th to 26th among 142 economies in the world this year, continuing to lead the way among large developing economies.The report said China is one of the world’s least indebted countries,boasts a savings rate of some 53 percent of GDP,and runs only moder ate budget deficits.However,China’s fairly poor results in the financial market development and technological readiness pillars pull down its overall competitiveness performance,said the report.

  6. Briefs

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@“The 4th national-& 11th South Central China young scientific researcher symposium on nuclear agricultural sciencee” was held in Zhangjiajie, Hunan on October 22,20O0. 53 representatives from home and abroad attended this symposium sponsored by Hunan Institute of Atomic Energy Application in Agriculture(HIAEAA). At the opening ceremony,HAAS and Zhongshan University, Guangdong, addressed congratuations on the symposium.

  7. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Benefits for Africa China’s investments in Africa have brought multiple benefits to the continent, providing better livelihood,more development opportunities and more choices for local people,said Liu Guijin, China’s special envoy on African affairs,at the end of the three-day World Economic Forum on Africa.He said China’s investments cater to Africa’s needs for a

  8. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Auto sales slows J.D.Power and Associates,a global marketing information services provider based in the United States,predicts that auto sales growth in the Chinese market which is expected to reach 30 percent in 2010,may slow to 10 percent in 2011, since the government has recognized troubles brought about by the rapid increase of automobiles on the street including traffic congestion,pollution and unrestrained expansion of production capacities.

  9. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Corn-processing limit According to Chinese Agriculture Minister Han Changfu,China will curb the amount of corn used in producing industrial chemicals to reduce the increasing pressure on grain supplies. The minister said the government aims to contain further processing of corn in non-food and non-livestock industrial usage.

  10. Briefs

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Pollution saver Pilot programs promoting the use of controlled-release fertilizer have been expanded to more than 20 provinces in China,compared with five in 2008,said the National Agro-Tech Extension and Service Center(NAESC),a department under the Ministry of Agriculture.The move is aimed at reducing pollution caused by the excessive use of fertilizer to protect the environment and save energy,the NAESC said.NAESC also predicted the use of controlled-release fertilizer could help increase agricultural production by 5 to 10 percent on average.

  11. Briefs

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Baotou Will Be the Largest RE Metals Production Base in ChinaFrom "Baotou Special Electroanalysis Forum of Fluoride-salt System Rare Earth Oxide", which was held by Baotou Rare Earth Leading Group Office, the production of Nd metal in Baotou in 2003 was 2,800 tons, with market shares 28%, and that in 2004 was estimated at 4,000 tons,

  12. Enhancing the crisis management briefing.

    Science.gov (United States)

    Clark, Daniel W; Volkmann, Peter

    2005-01-01

    The Crisis Management Briefing (CMB) is a powerful and versatile crisis intervention tool, effective within a wide variety of populations, settings, and critical incidents. Initially proposed by Everly (2000), the CMB uniquely fills the factual information void following a critical incident. Additionally, a CMB provides essential information on effective coping strategies and available helping resources, tailored to the specific incident(s). The authors expand on the original CMB construct using their combined field experience, offering recommendations on team composition, strategic planning factors, using CISDs vs. CMBs, and specific enhancements for the four phases. They conclude with examples of specific interventions across a variety of events to illustrate their recommendations.

  13. Impacts of climate change and socio-economic scenarios on flow and water quality of the Ganges, Brahmaputra and Meghna (GBM) river systems: low flow and flood statistics.

    Science.gov (United States)

    Whitehead, P G; Barbour, E; Futter, M N; Sarkar, S; Rodda, H; Caesar, J; Butterfield, D; Jin, L; Sinha, R; Nicholls, R; Salehin, M

    2015-06-01

    The potential impacts of climate change and socio-economic change on flow and water quality in rivers worldwide is a key area of interest. The Ganges-Brahmaputra-Meghna (GBM) is one of the largest river basins in the world serving a population of over 650 million, and is of vital concern to India and Bangladesh as it provides fresh water for people, agriculture, industry, conservation and for the delta system downstream. This paper seeks to assess future changes in flow and water quality utilising a modelling approach as a means of assessment in a very complex system. The INCA-N model has been applied to the Ganges, Brahmaputra and Meghna river systems to simulate flow and water quality along the rivers under a range of future climate conditions. Three model realisations of the Met Office Hadley Centre global and regional climate models were selected from 17 perturbed model runs to evaluate a range of potential futures in climate. In addition, the models have also been evaluated using socio-economic scenarios, comprising (1) a business as usual future, (2) a more sustainable future, and (3) a less sustainable future. Model results for the 2050s and the 2090s indicate a significant increase in monsoon flows under the future climates, with enhanced flood potential. Low flows are predicted to fall with extended drought periods, which could have impacts on water and sediment supply, irrigated agriculture and saline intrusion. In contrast, the socio-economic changes had relatively little impact on flows, except under the low flow regimes where increased irrigation could further reduce water availability. However, should large scale water transfers upstream of Bangladesh be constructed, these have the potential to reduce flows and divert water away from the delta region depending on the volume and timing of the transfers. This could have significant implications for the delta in terms of saline intrusion, water supply, agriculture and maintaining crucial ecosystems such

  14. Sustainable Markets Investment Briefings: Investment Treaties

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the second of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 2 explains how investment treaties between states work to protect and promote foreign investment.

  15. Intravitreal Bevacizumab (Avastin for Diabetic Retinopathy: The 2010 GLADAOF Lecture

    Directory of Open Access Journals (Sweden)

    J. Fernando Arevalo

    2011-01-01

    Full Text Available This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB on diabetic retinopathy (DR including diabetic macular edema (DME and proliferative diabetic retinopathy (PDR at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of 1.25 or 2.5 mg of bevacizumab for DME, PDR without tractional retinal detachment (TRD, and patients who experienced the development or progression of TRD after an intravitreal injection of 1.25 or 2.5 mg of bevacizumab before vitrectomy for the management of PDR. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA in diffuse DME. Therefore, in the future this new therapy could complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to panretina photocoagulation so that more selective therapy may be applied. Finally, TRD in PDR may occur or progress after IVB used as an adjuvant to vitrectomy. Surgery should be performed 4 days after IVB. Most patients had poorly controlled diabetes mellitus associated with elevated HbA1c, insulin administration, PDR refractory to panretinal photocoagulation, and longer time between IVB and vitrectomy.

  16. A brief history of videogames

    Directory of Open Access Journals (Sweden)

    Simone Belli

    2008-11-01

    Full Text Available The following text contains a brief journey through a short and yet intense adventure, the history of videogames. Since its beginnings in the 1950's decade to the present time, videogames have progressively changed from a hobby for ingeneering studens to the most powerfull leisure industry. In order to gain a better understanding of this phenomenon it is necessary to look over the path of its transformation from a retrospecive point of view. Such a look has necessarily to focus on those devices and games that had made a landmark in the history of videogames, taking them to their current position. Besides, it is crucial to address their implications in contemporary visual culture, along with current prejudices against them. This is a short account about a great history.

  17. Usability Briefing for hospital design

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    This PhD thesis is a contribution to an ongoing debate in Denmark about improving the building design processes of complex buildings, especially in relation to the current hospital developments. It provides knowledge about capturing user needs and defines the process model for usability briefing...... for hospital architecture from a user perspective. The thesis is based on comprehensive literature studies, three main case studies at hospitals,numerous expert interviews and workshops. The research results generate a better understanding of how knowledge about user needs, acquired from workshops...... participatory design, where users are seen as partners and co-creators, and where innovation and design are not done ‘for’ users, but‘with‘ or ‘by’ users. Research results from the presented hospital cases demonstrate that user-driven innovation is possible even in the hierarchic and technically advanced...

  18. Anthropic Rock: a brief history

    Directory of Open Access Journals (Sweden)

    R. B. Cathcart

    2011-03-01

    Full Text Available Stone tool-making is a reductive process. Synthetic rock manufacturing, preeminently an additive process, will not for-ever be confined to only the Earth-biosphere. This brief focuses on humanity's ancient past, hodiernal and possible future even more massive than present-day creation of artificial rocks within our exploitable Solar System. It is mostly Earth-centric account that expands the factual generalities underlying the unique non-copyrighted systemic technogenic rock classification first publicly presented (to the American Geological Society during 2001, by its sole intellectual innovator, James Ross Underwood, Jr. His pioneering, unique exposition of an organization of this ever-increasingly important aspect of the Anthropic Rock story, spatially expansive material lithification, here is given an amplified discussion for the broader geo and space science social group-purpose of encouragement of a completer 21st Century treatment of Underwood's explicative subject-chart (Fig. 2.

  19. Use of ERC-1671 vaccine in a patient with recurrent glioblastoma multiforme after progression during bevacizumab therapy: first published report

    NARCIS (Netherlands)

    Bota, D.A.; Alexandru-Abrams, D.; Pretto, C.; Hofman, F.M.; Chen, T.C.; Fu, B.; Carrillo, J.A.; Schijns, V.E.J.C.; Stathopoulos, A.

    2015-01-01

    Objectives: Glioblastoma multiforme (GBM) is a highly aggressive tumor, which recurs despite resection, focal beam radiation, and temozolomide chemotherapy. At recurrence, the only second-line treatment approved by the US Food and Drug Administration is bevacizumab (Avastin). To date, no single agen

  20. 19 CFR 207.23 - Prehearing brief.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing brief. 207.23 Section 207.23 Customs... EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.23 Prehearing brief... days prior to the date of the hearing specified in the notice of scheduling, a prehearing...

  1. UNESCO Policy Briefs on Early Childhood, 2002.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Early Childhood and Family Education Unit.

    This document consists of eight double-sided briefs addressing aspects of the field of early childhood education. Titles of the briefs are as follows: (1) "Early Childhood Care? Development? Education?," outlining the distinctions between these terms; (2) "Planning for Access: Develop a Data System First," highlighting Brazil's census to collect…

  2. Brief Psychotherapy Methods in Clinical Research.

    Science.gov (United States)

    Koss, Mary P.; And Others

    1986-01-01

    After a concise overview of the technical characteristics that define brief psychotherapy, the current use and misuse of these methods in clinical research on the outcome and process of treatment is examined. Suggests that brief psychotherapy methods possess unique technical advantages to the researcher. (Author/BL)

  3. Luminosity and spin-period evolution of GX 304-1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    Science.gov (United States)

    Sugizaki, Mutsumi; Yamamoto, Takayuki; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-08-01

    A report is made on the luminosity and pulse period evolution of the Be binary X-ray pulsar GX 304-1 during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, 12 outbursts repeated by ˜ 132.2 d were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were all found to recur with a well-defined period of 132.189 ± 0.02 d, which can be identified with the orbital period. The pulse period of ˜ 275 s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital elements obtained from the best-fit model, including the projected orbital semi-major axis ax sin i ≃ 500-600 light-s and an eccentricity e ≃ 0.5, are typical of Be binary X-ray pulsars.

  4. Luminosity and spin-period evolution of GX 304$-$1 during outbursts from 2009 to 2013 observed with the MAXI/GSC, RXTE/PCA, and Fermi/GBM

    CERN Document Server

    Sugizaki, Mutsumi; Mihara, Tatehiro; Nakajima, Motoki; Makishima, Kazuo

    2015-01-01

    A report is made on the luminosity and pulse-period evolution of the Be binary X-ray pulsar, GX 304$-$1, during a series of outbursts from 2009 to 2013 observed by MAXI/GSC, RXTE/PCA, and Fermi/GBM. In total, twelve outbursts repeated by $\\sim$ 132.2 days were observed, which is consistent with the X-ray periodicity of this object observed in the 1970s. These 12 outbursts, together with those in the 1970s, were found to all recur with a well defined period of 132.189$\\pm$0.02 d, which can be identified with the orbital period. The pulse period at $\\sim 275$ s, obtained from the RXTE/PCA and Fermi/GBM data, apparently exhibited a periodic modulation synchronized with the outburst period, suggesting the pulsar orbital motion, which is superposed on a secular spin-up trend throughout the entire active phase. The observed pulse-period changes were successfully represented by a model composed of the binary orbital modulation and pulsar spin up caused by mass accretion through an accretion disk. The orbital element...

  5. Cancer Vaccines: A Brief Overview.

    Science.gov (United States)

    Thomas, Sunil; Prendergast, George C

    2016-01-01

    Vaccine approaches for cancer differ from traditional vaccine approaches for infectious disease in tending to focus on clearing active disease rather than preventing disease. In this review, we provide a brief overview of different types of vaccines and adjuvants that have been investigated for the purpose of controlling cancer burdens in patients, some of which are approved for clinical use or in late-stage clinical trials, such as the personalized dendritic cell vaccine sipuleucel-T (Provenge) and the recombinant viral prostate cancer vaccine PSA-TRICOM (Prostvac-VF). Vaccines against human viruses implicated in the development and progression of certain cancers, such as human papillomavirus in cervical cancer, are not considered here. Cancers express "altered self" antigens that tend to induce weaker responses than the "foreign" antigens expressed by infectious agents. Thus, immune stimulants and adjuvant approaches have been explored widely. Vaccine types considered include autologous patient-derived immune cell vaccines, tumor antigen-expressing recombinant virus vaccines, peptide vaccines, DNA vaccines, and heterologous whole-cell vaccines derived from established human tumor cell lines. Opportunities to develop effective cancer vaccines may benefit from seminal recent advances in understanding how immunosuppressive barricades are erected by tumors to mediate immune escape. In particular, targeted ablation of these barricades with novel agents, such as the immune checkpoint drug ipilimumab (anti-CTLA-4) approved recently for clinical use, may offer significant leverage to vaccinologists seeking to control and prevent malignancy.

  6. Elliptic flow: a brief review

    Science.gov (United States)

    Snellings, Raimond

    2011-05-01

    One of the fundamental questions in the field of subatomic physics is the question of what happens to matter at extreme densities and temperatures as may have existed in the first microseconds after the Big Bang and exists, perhaps, in the core of dense neutron stars. The aim of heavy-ion physics is to collide nuclei at very high energies and thereby create such a state of matter in the laboratory. The experimental program began in the 1990s with collisions made available at the Brookhaven Alternating Gradient Synchrotron (AGS) and the CERN Super Proton Synchrotron (SPS), and continued at the Brookhaven Relativistic Heavy-Ion Collider (RHIC) with the maximum center-of-mass energies of \\sqrt{s_{NN}} = 4.75 , 17.2 and 200 GeV, respectively. Collisions of heavy ions at the unprecedented energy of 2.76 TeV recently became available at the LHC collider at CERN. In this review, I give a brief introduction to the physics of ultrarelativistic heavy-ion collisions and discuss the current status of elliptic flow measurements.

  7. NASA Tech Briefs, February 2009

    Science.gov (United States)

    2009-01-01

    Tech Briefs are short announcements of innovations originating from research and development activities of the National Aeronautics and Space Administration. They emphasize information considered likely to be transferable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. Topics covered include: Measuring Low Concentrations of Liquid Water in Soil; The Mars Science Laboratory Touchdown Test Facility; Non-Contact Measurement of Density and Thickness Variation in Dielectric Materials; Compact Microwave Fourier Spectrum Analyzer; InP Heterojunction Bipolar Transistor Amplifiers to 255 GHz; Combinatorial Generation of Test Suites; In-Phase Power-Combined Frequency Tripler at 300 GHz; Electronic System for Preventing Airport Runway Incursions; Smaller but Fully Functional Backshell for Cable Connector; Glove-Box or Desktop Virtual-Reality System; Composite Layer Manufacturing with Fewer Interruptions; Improved Photoresist Coating for Making CNT Field Emitters; A Simplified Diagnostic Method for Elastomer Bond Durability; Complex Multifunctional Polymer/Carbon-Nanotube Composites; Very High Output Thermoelectric Devices Based on ITO Nanocomposites; Reducing Unsteady Loads on a Piggyback Miniature Submarine; Ultrasonic/Sonic Anchor; Grooved Fuel Rings for Nuclear Thermal Rocket Engines; Pulsed Operation of an Ion Accelerator; Autonomous Instrument Placement for Mars Exploration Rovers; Mission and Assets Database; TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP); Trajectory Calculator for Finite-Radius Cutter on a Lathe; Integrated System Health Management Development Toolkit.

  8. Sustainable Markets Investment Briefings: Foreign investment contracts

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fourth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 4 sets out some of the ways in which foreign investment contracts can impact on sustainable development.

  9. Sustainable Markets Investment Briefings: International arbitration

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the fifth of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 5 explains how international arbitration works to resolve disputes between foreign investors and host states, and outlines some of the problems associated with its use, from a sustainable development perspective.

  10. A Brief History of CME Science

    Science.gov (United States)

    Alexander, David; Richardson, Ian G.; Zurbuchen, Thomas H.

    2006-01-01

    We present here a brief summary of the rich heritage of observational and theoretical research leading to the development of our current understanding of the initiation, structure, and evolution of Coronal Mass Ejections.

  11. Brief Review on the Relevance Theory

    Institute of Scientific and Technical Information of China (English)

    龚腾龙; 阿勒腾

    2015-01-01

    Relevance theory has had an impact on the study in various disciplines including linguistics,literature and so on. This paper gives a brief review of the relevance theory and two principles of relevance.

  12. Systemic Therapy: A New Brief Intervention Model.

    Science.gov (United States)

    Searight, H. Russell; Openlander, Patrick

    1984-01-01

    Describes a newly developing mode of problem-oriented brief therapy. The systemic therapy model emphasizes the interactional context of clients' problems and represents an efficient intervention paradigm. (Author/JAC)

  13. NASA Tech Briefs, February 2012

    Science.gov (United States)

    2012-01-01

    This issue contains the following briefs: (1) Optical Comb from a Whispering Gallery Mode Resonator for Spectroscopy and Astronomy Instruments Calibration (2) Real-Time Flight Envelope Monitoring System (3) Nemesis Autonomous Test System (4) Mirror Metrology Using Nano-Probe Supports (5) Automated Lab-on-a-Chip Electrophoresis System (6) Techniques for Down-Sampling a Measured Surface Height Map for Model Validation (7) Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter (8) Frequency to Voltage Converter Analog Front-End Prototype (9) Dust-Tolerant Intelligent Electrical Connection System (10) Gigabit Ethernet Asynchronous Clock Compensation FIFO (11) High-Speed, Multi-Channel Serial ADC LVDS Interface for Xilinx Virtex-5 FPGA (12) Glovebox for GeoLab Subsystem in HDU1-PEM (13) Modified Process Reduces Porosity when Soldering in Reduced Gravity Environments (14) Use of Functionalized Carbon Nanotubes for Covalent Attachment of Nanotubes to Silicon (15) Flexible Plug Repair for Shuttle Wing Leading Edge (16) Three Dimensionally Interlinked, Dense, Solid Form of Single-Walled CNT Ropes (17) Axel Robotic Platform for Crater and Extreme Terrain Exploration (18) Site Tamper and Material Plow Tool - STAMP (19) Magnetic Interface for Segmented Mirror Assembly (20) Transpiration-Cooled Spacecraft-Insulation-Repair Fasteners (21) Fluorescence-Based Sensor for Monitoring Activation of Lunar Dust (22) Aperture Ion Source (23) Virtual Ultrasound Guidance for Inexperienced Operators (24) Model-Based Fault Diagnosis: Performing Root Cause and Impact Analyses in Real Time (25) Interactive Schematic Integration Within the Propellant System Modeling Environment (26) Magnetic and Electric Field Polarizations of Oblique Magnetospheric Chorus Waves (27) Variable Sampling Mapping.

  14. Environmental actual situation in Guatemala. Executive brief

    International Nuclear Information System (INIS)

    In this brief prepared by the Consejo Permanente de Cambio y Variabilidad Climatica the climate in Guatemala is described including the current situation on variation of rainy season, air humidity, influence of the Nino current. This brief was prepared in order to plan a strategy to be adopted by all the institutions that are involved in environmental issues and in this way to deal with the climate change and the impact of the different energy sources in the environment

  15. 37 CFR 2.128 - Briefs at final hearing.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.128 Briefs at final hearing. (a)(1) The brief of the party in the position of plaintiff shall be due not... first brief. A reply brief by the party in the position of plaintiff, if filed, shall be due not...

  16. 22 CFR 1423.25 - Filing of brief.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Filing of brief. 1423.25 Section 1423.25 Foreign... PROCEEDINGS § 1423.25 Filing of brief. Any party desiring to submit a brief to the Administrative Law Judge... Judge, but not in excess of thirty (30) days from the close of the hearing. Copies of any brief shall...

  17. 29 CFR 458.86 - Filing of brief.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Filing of brief. 458.86 Section 458.86 Labor Regulations... OF CONDUCT Hearing and Related Matters § 458.86 Filing of brief. Any party desiring to submit a brief... Law Judge may grant a reasonable extension of time. Copies of such brief shall be served on all of...

  18. 76 FR 50715 - Briefing on Partner Vetting System Pilot Program

    Science.gov (United States)

    2011-08-16

    ...; ] DEPARTMENT OF STATE Agency for International Development Briefing on Partner Vetting System Pilot Program... briefing. SUMMARY: Notice is hereby given of a briefing on the Partner Vetting System (PVS) pilot program. The objective of the briefing is to provide information about the PVS pilot program. Members of...

  19. Case Briefs in Legal English Classes

    Directory of Open Access Journals (Sweden)

    Bilová Stĕpánka

    2016-06-01

    Full Text Available A case brief can be described as a succinct summary of a case which specifies the facts, procedural history, legal issue(s, court decision and legal reasoning supporting the judgment, even though exact formats may vary. Case briefing is a demanding activity which is required from students during their law studies. The goal is to teach students to focus on the essential parts of the case and to obtain a thorough understanding of the case and the reasoning, which means the students need to employ their analytical and critical thinking skills.

  20. Optical Disk Formats: A Briefing. ERIC Digest.

    Science.gov (United States)

    Schamber, Linda

    This digest begins with a brief description and review of the development of optical disks. Optical disk formats are then described by capability: Read Only Memory (ROM), Write Once, Read Many (WORM), Interactive (I), and Erasable (E); forms of information (audio, text or data, video or graphics, or a combination); and disk size (most often 12 or…

  1. Genre Identification of Very Brief Musical Excerpts

    Science.gov (United States)

    Mace, Sandra T.; Wagoner, Cynthia L.; Teachout, David J.; Hodges, Donald A.

    2012-01-01

    The purpose of this study was to examine how well individuals were able to identify different music genres from very brief excerpts and whether musical training, gender and preference played a role in genre identification. Listeners were asked to identify genre from classical, jazz, country, metal, and rap/hip hop excerpts that were 125, 250, 500,…

  2. Characteristics of Improved School Districts. Research Brief

    Science.gov (United States)

    Center for Comprehensive School Reform and Improvement, 2006

    2006-01-01

    This research brief presents an overview of a 2004 study by G.S. Shannon and P. Bylsma entitled "Characteristics of Improved School Districts: Themes from Research" (Olympia, WA: Office of Superintendent of Public Instruction). The authors reviewed more than 80 research articles that investigated the attributes of schools and districts that have…

  3. Update: Preparation Briefing Meeting for Shanghai

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ On March 9,the preparation briefing meeting for Shanghai World Expo was held in Beijing.Shanghai Mayor Han Zheng,CCPIT Chairman Wan Jifei,Assistant Foreign Minister Liu Jieyi and three deputy directors of Shanghai World Expo Organizing Committee addressed the meeting.

  4. Educational Access in India. Country Policy Brief

    Science.gov (United States)

    Online Submission, 2009

    2009-01-01

    This Policy Brief describes and explains patterns of access to schools in India. It outlines policy and legislation on access to education and provides an analysis of access, vulnerability and exclusion. The quantitative data is supported by a review of research which explains the patterns of access and exclusion. It is based on findings from the…

  5. Sustainable investment in Turkey: issue brief

    OpenAIRE

    Ararat, Melsa; Yurtoğlu, Burçin B.; Yurtoglu, Burcin B.; Suel, Esra

    2011-01-01

    IFC launched a series of sustainable investment country reports initially covering the largest emerging capital markets attracting global portfolio investors: Brazil, India, and China. Further reports have been added to the series covering Sub-Saharan Africa, the Middle East and North Africa, and Turkey. This Issue Brief 's the summary version of the report, “Sustainable Investment in Turkey,”

  6. Counseling Services and Student Success. Research Brief

    Science.gov (United States)

    Francis, Perry C.; Horn, Aaron S.

    2016-01-01

    The purpose of this research brief is to provide an overview of mental health issues and counseling services on college campuses. The findings from several national surveys are reviewed to estimate the prevalence of anxiety and depression, suicide and suicidal ideation, and violence among college students. Common prevention and treatment programs…

  7. Briefs for English-Speaking Parents, 1996.

    Science.gov (United States)

    Howley, Craig

    In plain language, these six ready-to-copy briefs state what researchers and practitioners have learned about various ways parents can help their children do well in school. "Calculating the Risks: When Should Parents Add or Subtract?" discusses the normal risks of life, the intensification of risk by poverty, and how parents can keep children…

  8. Four Useful Interventions in Brief Family Therapy.

    Science.gov (United States)

    de Shazer, Steve; Molnar, Alex

    1984-01-01

    Describes four interventions in brief family therapy, illustrated by case examples. Interventions are aimed at helping clients solve problems, and three assumptions about the nature of change are described. Results of these interventions suggest there is no clinical distinction between clients' perceived change and observed change. (JAC)

  9. A Brief Introduction to SLA Theories

    Institute of Scientific and Technical Information of China (English)

    佘阿莉

    2015-01-01

    There are a large number of theories,models or hypotheses in the history of SLA research.A brief introduction is made in this paper on several typical ones which have a great influence on foreign language teaching and it is hoped to be useful for the study of SLA research and foreign language teaching.

  10. Quality Physical Education. NASPE Resource Brief

    Science.gov (United States)

    National Association for Sport and Physical Education, 2013

    2013-01-01

    A quality physical education program provides learning opportunities, appropriate instruction, meaningful and challenging content, and student and program assessment. In addition, a quality physical education improves mental alertness, academic performance, and readiness and enthusiasm for learning in the nation's youth. This brief provides a list…

  11. 14 CFR 91.519 - Passenger briefing.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Passenger briefing. 91.519 Section 91.519 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... be supplemented by printed cards for the use of each passenger containing— (1) A diagram of,...

  12. Competency-Based Business Degree. Issue Brief

    Science.gov (United States)

    Washington State Board for Community and Technical Colleges, 2014

    2014-01-01

    In January 2015, thirteen Washington community colleges launched an online, competency-based business transfer degree--the first in the state's community and technical college system. This issue brief provides answers to commonly asked questions about the new competency-based degree.

  13. A brief history of dosage compensation

    Indian Academy of Sciences (India)

    Stanley M. Gartler

    2014-08-01

    In 1914, H. J. Muller postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.

  14. The Neighboring Field of Brief Individual Psychotherapy.

    Science.gov (United States)

    Gustafson, Jim

    1987-01-01

    Presents field of brief individual psychotherapy as coherent set of conventions, despite its diverse origins in schools of dynamic, behavioral, interpersonal or cognitive, and strategic psychotherapy. Proposes advantages and drawbacks of shared conventions and discusses how neighboring field could help field of family therapy reduce its errors.…

  15. Grammar Schools: Brief Flowering of Social Mobility?

    Science.gov (United States)

    Barker, Bernard

    2012-01-01

    Grammar schools are increasingly remembered, especially by right-wing ideologues, as the agents of a "brief flowering" of post-war social mobility. This article presents statistical, documentary and interview evidence of secondary education in the eleven plus era, and finds nothing to justify the claim that selective schools produced a general…

  16. Citizens Science for Sustainability (SuScit) Project Briefing

    DEFF Research Database (Denmark)

    Eames, Malcolm; Mortensen, Jonas Egmose; Adebowale, Maria;

    This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project.......This project briefing gives a short overview of the Citizens Science for Sustainability (SuScit) Project....

  17. 42 CFR 405.1120 - Filing briefs with the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Filing briefs with the MAC. 405.1120 Section 405....1120 Filing briefs with the MAC. Upon request, the MAC will give the party requesting review, as well... ending with the date the brief is received by the MAC will not be counted toward the...

  18. 39 CFR 3001.115 - Participant statement or brief.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Participant statement or brief. 3001.115 Section... Participant statement or brief. (a) Participant statement. Upon the filing of the petition for review of a... or she may file a brief as described in paragraph (b) of this section presenting the arguments,...

  19. On the Integration of Science and Practice in Brief Psychotherapy.

    Science.gov (United States)

    May, Robert

    1992-01-01

    Responds to previous article by Steenbarger on science-practice integration in brief counseling and therapy. Focuses specifically on the integration of science and practice in brief psychotherapy. Elaborates on agreements and disagreements concerning Steenbarger's analysis of brief psychotherapy. Muses over what is lost as well as gained in brief…

  20. 狼疮肾炎患者anti-GBM与anti-dsDNA和anti-NuA相关性研究%Anti- GBM and Anti- ds DNA Associated with Anti- NuA in Patients with Lupus Nephritis

    Institute of Scientific and Technical Information of China (English)

    李成海; 张聪恪; 赵静; 邹国林

    2006-01-01

    目的 探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系.方法 反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系.结果 28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性.并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致.结论 anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义.

  1. Three brief assessments of math achievement.

    Science.gov (United States)

    Steiner, Eric T; Ashcraft, Mark H

    2012-12-01

    Because of wide disparities in college students' math knowledge-that is, their math achievement-studies of cognitive processing in math tasks also need to assess their individual level of math achievement. For many research settings, however, using existing math achievement tests is either too costly or too time consuming. To solve this dilemma, we present three brief tests of math achievement here, two drawn from the Wide Range Achievement Test and one composed of noncopyrighted items. All three correlated substantially with the full achievement test and with math anxiety, our original focus, and all show acceptable to excellent reliability. When lengthy testing is not feasible, one of these brief tests can be substituted.

  2. Interviewing: Methodological Briefs - Impact Evaluation No. 12

    OpenAIRE

    Patricia Rogers; Bronwen McDonald

    2014-01-01

    Interviews are easy to do badly and hard to do well - good planning, adequate time and appropriate skills are required. The type of interview should be carefully chosen to suit the situation rather than choosing a type of interview (such as focus groups) simply because it is commonly used. Interviews with children raise particular ethical issues that need to be carefully considered and fully addressed. This brief outlines key issues to consider in planning interviews for impact evaluation, ta...

  3. A brief history of topographical anatomy.

    Science.gov (United States)

    Standring, Susan

    2016-07-01

    This brief history of topographical anatomy begins with Egyptian medical papyri and the works known collectively as the Greco-Arabian canon, the time line then moves on to the excitement of discovery that characterised the Renaissance, the increasing regulatory and legislative frameworks introduced in the 18th and 19th centuries, and ends with a consideration of the impact of technology that epitomises the period from the late 19th century to the present day. This paper is based on a lecture I gave at the Winter Meeting of the Anatomical Society in Cambridge in December 2015, when I was awarded the Anatomical Society Medal. PMID:27278889

  4. The Raychaudhuri equations: A brief review

    Indian Academy of Sciences (India)

    Sayan Kar; Soumitra Sengupta

    2007-07-01

    We present a brief review on the Raychaudhuri equations. Beginning with a summary of the essential features of the original article by Raychaudhuri and subsequent work of numerous authors, we move on to a discussion of the equations in the context of alternate non-Riemannian spacetimes as well as other theories of gravity, with a special mention on the equations in spacetimes with torsion (Einstein–Cartan–Sciama–Kibble theory). Finally, we give an overview of some recent applications of these equations in general relativity, quantum field theory, string theory and the theory of relativisitic membranes. We conclude with a summary and provide our own perspectives on directions of future research.

  5. Brief history of electronic stereoscopic displays

    Science.gov (United States)

    Lipton, Lenny

    2012-02-01

    A brief history of recent developments in electronic stereoscopic displays is given concentrating on products that have succeeded in the market place and hence have had a significant influence on future implementations. The concentration is on plano-stereoscopic (two-view) technology because it is now the dominant display modality in the marketplace. Stereoscopic displays were created for the motion picture industry a century ago, and this technology influenced the development of products for science and industry, which in turn influenced product development for entertainment.

  6. 2. Der erkenntnistheoretische Grundentwurf im 7. Brief

    OpenAIRE

    Liatsi, Maria

    2014-01-01

    Der Brief ist nach Dions Tod verfaßt und richtet sich an die Verwandten und Freunde Dions, gleichzeitig richtet er sich nach Form und Inhalt an die damalige kulturelle Öffentlichkeit. Dion war aus der ihm von Dionysios II. auferlegten Verbannung zurückgekehrt und hatte, ausgerüstet mit einigen Schiffen und einem kleinen Söldnerheer, Syrakus besetzt. Das Volk jubelte ihm wie einem Retter und Befreier zu. Das war im Herbst 357 gewesen. Der Tyrann leistete bis Ende 355 in Ortygia Widerstand und ...

  7. A Brief Analysis on William Blake's London

    Institute of Scientific and Technical Information of China (English)

    张莉; 尚彦飞

    2014-01-01

    William Blake (1757-1827) is a renowned British poet in the 18th century. His lyric poems display the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is a well-known lyric poetry, which is thought to be the best vesicle in the West. This paper will analyse this poem in terms of its form, theme, and im-age and then draw a brief conclusion for the characteristics of William Blake's poem.

  8. A brief analysis on English etymology

    Institute of Scientific and Technical Information of China (English)

    李明珠

    2015-01-01

    In the process of learning English, proficiency in vocabulary is the key point to study a language well. Obviously, it’s very crucial to know about the origin and history of the words. Research on English etymology is conducive to memory, interpretation and understanding of the words. Generally speaking, English etymology is closely connected with British history. Western culture also has exerted profound impact on English etymology, which leads to considerable borrowings pouring into English vocabulary. In brief, this dissertation will inquire into English etymology preliminarily.

  9. Negotiating Visualities in Briefing and Design

    DEFF Research Database (Denmark)

    Koch, Christian; Bendixen, Mads

    2007-01-01

    and prescription, changing their roles and configurations, and intersecting and affecting the project process in characteristic ways. Visual representations play a temporary role, and ‘time’ and ‘phase’ set boundaries for them. For practice, the analysis suggests the implication that communitarian management......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations...

  10. Negotiating Visualizations in Briefing and Design

    DEFF Research Database (Denmark)

    Bendixen, Mads; Koch, Christian

    2007-01-01

    and prescription, changing their roles and configurations, and intersecting and affecting the project process in characteristic ways. Visual representations play a temporary role, and ‘time’ and ‘phase’ set boundaries for them. For practice, the analysis suggests the implication that communitarian management......Building on an in-depth ethnographic study and the approaches of ‘practice-based studies’ and ‘science and technology studies’, the role of visual representations is explored in briefing and design processes. Three characteristic ways in which drawings contribute to ongoing negotiations...

  11. Energy in Croatia 2008, Brief Report

    International Nuclear Information System (INIS)

    The sixth edition of concise energy review 'Energy in Croatia 2008' presents brief information on relations and developments in the Croatian energy sector to domestic and international audience. Apart od basic energy indicators, this report provides data on energy production and consumption, as well as energy commodities, balances for the past period. In addition, the report gives other interesting indicators, such as, basic facts on the Republic of Croatia, air pollutant emissions, energy prices, energy capacities and energy reserves. The report presents the croatian energy sector in practical and informative style

  12. Continuous Briefing and User Participation in Building Projects

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2006-01-01

    into the building is required. A building project is often part of a change process of the organisation that is going to occupy the building, and this change process should be management carefully to reach a successful result. An important aspect of briefing is to manage the par-ticipation of the coming users......Briefing is not just about specifying needs as requirements but also about evaluating how well design pro-posals fulfill the needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the pre-project stage to create a basis for the project decision...... in the process. This paper includes a literature study on briefing and user participation in building projects and presents a case study of a major ongoing building project DR Byen - a new headquarters for DR (Danish Broadcasting Corporation) in Copenhagen. The paper describes the briefing processes...

  13. A brief etymology of the collateral circulation.

    Science.gov (United States)

    Faber, James E; Chilian, William M; Deindl, Elisabeth; van Royen, Niels; Simons, Michael

    2014-09-01

    It is well known that the protective capacity of the collateral circulation falls short in many individuals with ischemic disease of the heart, brain, and lower extremities. In the past 15 years, opportunities created by molecular and genetic tools, together with disappointing outcomes in many angiogenic trials, have led to a significant increase in the number of studies that focus on: understanding the basic biology of the collateral circulation; identifying the mechanisms that limit the collateral circulation's capacity in many individuals; devising methods to measure collateral extent, which has been found to vary widely among individuals; and developing treatments to increase collateral blood flow in obstructive disease. Unfortunately, accompanying this increase in reports has been a proliferation of vague terms used to describe the disposition and behavior of this unique circulation, as well as the increasing misuse of well-ensconced ones by new (and old) students of collateral circulation. With this in mind, we provide a brief glossary of readily understandable terms to denote the formation, adaptive growth, and maladaptive rarefaction of collateral circulation. We also propose terminology for several newly discovered processes that occur in the collateral circulation. Finally, we include terms used to describe vessels that are sometimes confused with collaterals, as well as terms describing processes active in the general arterial-venous circulation when ischemic conditions engage the collateral circulation. We hope this brief review will help unify the terminology used in collateral research.

  14. Pre-flight safety briefings, mood and information retention.

    Science.gov (United States)

    Tehrani, Morteza; Molesworth, Brett R C

    2015-11-01

    Mood is a moderating factor that is known to affect performance. For airlines, the delivery of the pre-flight safety briefing prior to a commercial flight is not only an opportunity to inform passengers about the safety features on-board the aircraft they are flying, but an opportunity to positively influence their mood, and hence performance in the unlikely event of an emergency. The present research examined whether indeed the pre-flight safety briefing could be used to positively impact passengers' mood. In addition, the present research examined whether the recall of key safety messages contained within the pre-flight safety briefing was influenced by the style of briefing. Eighty-two participants were recruited for the research and divided into three groups; each group exposed to a different pre-flight cabin safety briefing video (standard, humorous, movie theme). Mood was measured prior and post safety briefing. The results revealed that pre-flight safety briefing videos can be used to manipulate passengers' mood. Safety briefings that are humorous or use movie themes to model their briefing were found to positively affect mood. However, there was a trade-off between entertainment and education, the greater the entertainment value, the poorer the retention of key safety messages. The results of the research are discussed from both an applied and theoretical perspective.

  15. The Brief Norwegian Safety Climate Inventory (Brief NORSCI) – Psychometric properties and relationships with shift work, sleep, and health

    OpenAIRE

    Nielsen, Morten Birkeland; Hystad, Sigurd William; Eid, Jarle

    2015-01-01

    The aim of this study was to establish the psychometric properties of the 11-item Brief Norwegian Safety Climate Inventory (Brief NORSCI) and to examine direct and indirect associations between shift work schedules, sleep problems, health complaints, and psychological safety climate. The study was based on a questionnaire survey in a randomly drawn cross-sectional sample of 8066 workers from the Norwegian offshore petroleum industry. The results showed that the Brief NORSCI has good psychomet...

  16. Affordances for robots: a brief survey

    Directory of Open Access Journals (Sweden)

    Thomas E. Horton

    2012-12-01

    Full Text Available In this paper, we consider the influence of Gibson's affordance theory on the design of robotic agents. Affordance theory (and the ecological approach to agent design in general has in many cases contributed to the development of successful robotic systems; we provide a brief survey of AI research in this area. However, there remain significant issues that complicate discussions on this topic, particularly in the exchange of ideas between researchers in artificial intelligence and ecological psychology. We identify some of these issues, specifically the lack of a generally accepted definition of "affordance" and fundamental differences in the current approaches taken in AI and ecological psychology. While we consider reconciliation between these fields to be possible and mutually beneficial, it will require some flexibility on the issue of direct perception.

  17. The Financial Therapy Association: A Brief History

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2010-10-01

    Full Text Available The purpose of this brief review is to provide a historical context for the conceptualization, development, and launch of the Financial Therapy Association (FTA. The FTA membership base consists of practicing financial planners, financial counselors, psychologists, marriage and family therapists, social workers, financial coaches, psychotherapists, and researchers from these and other disciplines. From the outset, the Association’s purpose has encompassed five goals:To promote a vision of financial therapy, which is the study of cognitive, emotional, behavioral, relational, economic, and integrative aspects of financial health.To provide a forum for researchers, practitioners, the media, and policy makers to share research and practice methods and models of financial therapy.To promote methods of training for those involved in financial therapy.To inform policy and practice management standards as these relate to financial therapy.To stimulate and disseminate clinical, experimental, and survey research on financial therapy.

  18. Brief mindfulness induction reduces inattentional blindness.

    Science.gov (United States)

    Schofield, Timothy P; Creswell, J David; Denson, Thomas F

    2015-12-01

    Prior research has linked mindfulness to improvements in attention, and suggested that the effects of mindfulness are particularly pronounced when individuals are cognitively depleted or stressed. Yet, no studies have tested whether mindfulness improves declarative awareness of unexpected stimuli in goal-directed tasks. Participants (N=794) were either depleted (or not) and subsequently underwent a brief mindfulness induction (or not). They then completed an inattentional blindness task during which an unexpected distractor appeared on the computer monitor. This task was used to assess declarative conscious awareness of the unexpected distractor's presence and the extent to which its perceptual properties were encoded. Mindfulness increased awareness of the unexpected distractor (i.e., reduced rates of inattentional blindness). Contrary to predictions, no mindfulness×depletion interaction emerged. Depletion however, increased perceptual encoding of the distractor. These results suggest that mindfulness may foster awareness of unexpected stimuli (i.e., reduce inattentional blindness).

  19. Briefing paper -- Remedial Action Assessment System

    Energy Technology Data Exchange (ETDEWEB)

    Buelt, J.L.

    1990-04-01

    Congress has mandated a more comprehensive management of hazardous wastes with the Resource Conservation and Recovery Act (RCRA), the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund'') and the Superfund Amendment and Reauthorization Act (SARA). This mandate includes restoration of disposal sites contaminated through past disposal practices. This mandate applies to facilities operated for and by the Department of Energy (DOE), just as it does to industrial and other institutions. To help implement the CERCLA/SARA remedial investigation and feasibility study (RI/FS) process in a consistent, timely, and cost-effective manner, a methodology needs to be developed that will allow definition, sorting, and screening of remediation technologies for each operable unit (waste site). This need is stated specifically in Section 2.2.2.1 of the October 1989 Applied Research, Development, Demonstration, Testing, and Evaluation (RDDT E) Plan of the DOE. This Briefing Paper is prepared to respond to this need. 1 fig.

  20. Bats and Viruses: a Brief Review

    Institute of Scientific and Technical Information of China (English)

    Lin-Fa Wang

    2009-01-01

    Bats, probably the most abundant, diverse and geographically dispersed vertebrates on earth, have recently been shown to be the reservoir hosts of a number of emerging viruses responsible for severe human and livestock disease outbreaks. Flying foxes have been demonstrated to be the natural reservoir for Hendra and Nipah viruses. Evidence supporting the possibility of bats as potential reservoirs for SARS coronavirus (SARS-CoV) and Ebola virus has also been reported. The recent discovery of these viruses and other viruses occurring naturally in the bat population provides a unique insight into a diverse pool of potentially emergent and pathogenic viruses. The factors which influence the ability of zoonotic viruses to effectively cross the species barrier from bats to other animal populations are poorly understood. A brief review is provided here on the recently emerged bat viruses and on current and future strategies for research in this area.

  1. Delusional disorders in dermatology: a brief review.

    Science.gov (United States)

    Robles, David T; Romm, Sharon; Combs, Heidi; Olson, Jonathan; Kirby, Phil

    2008-01-01

    There are several unique psychiatric disorders that are likely to present to a dermatologist because of their accompanying skin complaints. Delusions of parasitosis (DP) is a fixed, false belief of parasitic infestation that may lead patients to compulsively self-mutilate while attempting to remove the non-existent parasites. Morgellons disease is a controversial condition characterized by a fixed belief that fibers that are imbedded or extruding from the skin; this condition is likely in the spectrum of DP. Body dysmorphic disorder (BDD) is a preoccupation with an imagined defect in appearance that causes significant distress and is associated with time consuming rituals, isolation, depression, and increased risk of suicide. Olfactory reference syndrome (ORS) is a preoccupation with body odor leading to the stigmata of shame, embarrassment, and social isolation. This brief review examines each of these conditions and their management because any one of them may present to a dermatologist. PMID:18713583

  2. The nuclear materials control technology briefing book

    Energy Technology Data Exchange (ETDEWEB)

    Hartwell, J.K.; Fernandez, S.J.

    1992-03-01

    As national and international interests in nuclear arms control and non-proliferation of nuclear weapons, intensify, it becomes ever more important that contributors be aware of the technologies available for the measurement and control of the nuclear materials important to nuclear weapons development. This briefing book presents concise, nontechnical summaries of various special nuclear material (SNM) and tritium production monitoring technologies applicable to the control of nuclear materials and their production. Since the International Atomic Energy Agency (IAEA) operates a multinational, on-site-inspector-based safeguards program in support of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), many (but not all) of the technologies reported in this document are in routine use or under development for IAEA safeguards.

  3. A brief history of gravitational wave research

    CERN Document Server

    Chen, Chiang-Mei; Ni, Wei-Tou

    2016-01-01

    For the benefit of the readers of this journal, the editors requested that we prepare a brief review of the history of the development of the theory, the experimental attempts to detect them, and the recent direct observations of gravitational waves (GWs). The theoretical ideas and disputes beginning with Einstein in 1916 regarding the existence and nature of GWs and the extent to which one can rely on the electromagnetic analogy, especially the controversies regarding the quadrupole formula and whether GWs carry energy, are discussed. The theoretical conclusions eventually received strong observational support from the binary pulsar. This provided compelling, although indirect, evidence for GWs carrying away energy--as predicted by the quadrupole formula. On the direct detection experimental side, Weber started more than 50 years ago. In 1966, his bar for GW detection reached a strain sensitivity of a few times 10^-16. His announcement of coincident signals (now considered spurious) stimulated many experimen...

  4. Brief assessment of negative dysmorphic signs

    Directory of Open Access Journals (Sweden)

    Patrizia Fiori

    2010-09-01

    Full Text Available Patrizia Fiori1, Antonio Monaco1, Maria Giannetti Luigi21Central Operative Unit of Neurology, 2Infantile Neuropsychiatry and Social Service, ASL AV, Civil Hospital of Ariano Irpino, University of Naples, ItalyAbstract: Body dysmorphic disorder is a body image dysperception, characterized either by an excessive preoccupation with a presumed or minimal flaw in appearance, or by unrecognition, denial, or even neglect regarding an obvious defect. These features are evaluated by a novel questionnaire, the Brief Assessment of Negative Dysmorphic Signs (BANDS. Moreover, the temperament and character background is examined. The relationship with addictive mentality/behavior and schizoaffectivity is also highlighted. Lastly, the potential shift toward cognitive impairment and dementia is considered.Keywords: body dysmorphic disorder, schizoaffectivity, addiction, behavioral-cognitive impairment

  5. Astrobiology Research in India - A Brief Overview

    Science.gov (United States)

    Peda Nageswara Rao, Pinnamaneni

    2012-07-01

    strobiology is study of the origin, evolution, distribution and future of life on Earth and in the Universe. The discovery of amino acids in carbonaceous chondrite meteorites and complex organic molecules in interstellar clouds, comets and interplanetary dust forced biological interest into space research. The existence of different life forms in extreme environments of Earth, their ability to adapt and survive for long periods in stasis and then recover has given hope that life might exist on other planets. A lot more insight into the origin of life is gained by studying the analogous life on Earth to predict how extraterrestrial life might live. In this paper, a brief account is given on the exogenous and endogenous origin of life on Earth, biochemical basis of life, the need and approach for research in astrobiology, scientific strength of Indian institutions to launch space missions in search of life. A review of the results of the two balloon experiments carried out by Indian Space Research Organization (ISRO) in collaboration with many research institutes in the country as well as the studies carried out elsewhere is also given. An attempt made to address the limitations of the previous experiments, improvements needed, implications of engineering design changes to meet the gaps and institutional resources needed to carry out further studies in astrobiology in the Indian context. A few priority investigations that can be carried out in collaboration with premier national laboratories in India have been identified. A brief account of the international missions that are aimed at finding out habitable Earth-like planets is given. The educational opportunities and interdisciplinary unifying nature of astrobiology research are discussed. The paper concludes with an approach that can be adopted for coordinating the research in this new space science in a programmatic mode.

  6. Brief description of the Wackersdorf Reprocessing Facility

    International Nuclear Information System (INIS)

    The DWK is now planning the construction and operation of a facility for the reprocessing of spent fuel elements and the fabrication of mixed-oxide fuel elements which will initially have an average daily throughput of 2 tons (t) of nuclear fuel. The application required by the Atomic Law was submitted to the Bavarian State Ministry for State Development and Environmental Matters on October 28, 1982. According to Par. 3, Section 1, No. 1 of the Atomic Law Procedural Ordinance such an application for permission in accordance with par. 7 AtL must explicitly be accompanied by a safety report which shall make it possible for third parties to make a judgment whether the impacts associated with the facility and its operation could damage their rights. The safety report is intended to present and explain the concept of the facility, the safety-technological design bases, and the operation of the plant, including its operation and safety systems and the impacts and proposed preventive measures. In addition to the detailed presentations in the safety report, Par. 3 of the Atomic Law Procedural Ordinance also requires a brief description of the plant designed for general public understanding, suitable for the design, which will also explain the expected impacts on the general environment and the surrounding area. Hence the brief description presents and explains the following matters: the site; the technology and state of the art for reprocessing of spent nuclear fuel; the structure and function of the proposed facility; safety provisions of the proposed facility and the management of perturbations in operation; the impacts of the facility and its operation on the environment; measures to be taken for dealing with the radioactive wastes; and provisions for ultimate shut-down of the facility

  7. 42 CFR 423.2120 - Filing briefs with the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Filing briefs with the MAC. 423.2120 Section 423... (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Reopening, ALJ Hearings, MAC review, and Judicial Review § 423.2120 Filing briefs with the MAC. Upon request, the MAC will give...

  8. Use of Brief Intelligence Tests in the Identification of Giftedness

    Science.gov (United States)

    Pierson, Eric E.; Kilmer, Lydia M.; Rothlisberg, Barbara A.; McIntosh, David E.

    2012-01-01

    Schools often administer brief intelligence tests as the first step in the identification of students who are cognitively gifted. However, brief measures are often used without consideration of underlying constructs or the psychometric properties of the measures and without regard to the links between screening decisions and educational…

  9. Fetal Alcohol Exposure Reduces Adult Brain Plasticity. Science Briefs

    Science.gov (United States)

    National Scientific Council on the Developing Child, 2007

    2007-01-01

    "Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This Brief summarizes the findings and implications of "Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice" (I. Y. Choi; A. M. Allan; and L. A. Cunningham). Observations of mice…

  10. 5 CFR 185.136 - Post-hearing briefs.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Post-hearing briefs. 185.136 Section 185.136 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file...

  11. Drama in design: An open brief to design for wellbeing

    NARCIS (Netherlands)

    Liao, T.; Person, F.E.O.K.

    2012-01-01

    This paper presents a design module in which student teams were challenged in an open brief to design for wellbeing. To design for wellbeing is difficult. Wellbeing is ambiguous, hard to define and highly personal. In the process of defining their own briefs, a drama workshop was set up to help the

  12. Case Book of Brief Psychotherapy with College Students.

    Science.gov (United States)

    Cooper, Stewart E., Ed.; Archer, James Jr., Ed.; Whitaker, Leighton C., Ed.

    This book examines brief therapy in a developmental context with young adults whose clinical problems often relate to or are caused by significant developmental impasses. The purpose in presenting this book is to provide case studies to illustrate a variety of brief therapy approaches with young adults who are college students between the ages of…

  13. First-Session Competency: The Brief Strategic Therapy Scale-1

    Science.gov (United States)

    Amini, Rachelle L.; Woolley, Scott R.

    2011-01-01

    The first session in brief strategic therapy is the most critical phase of treatment. More than a mere "assessment phase," the first session in a true intervention sets the stage for all subsequent therapeutic maneuvers. This article presents a supervisory observation tool, the Brief Strategic Therapy Scale-1 (BSTS-1), a fidelity measure proposed…

  14. Do Disadvantaged Neighborhoods Affect Children's Verbal Skills? Evaluation Science Brief

    Science.gov (United States)

    National Forum on Early Childhood Program Evaluation, 2008

    2008-01-01

    "Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study "Durable Effects of Concentrated Disadvantage on Verbal Ability Among African-American Children" (R. Sampson; R. Sharkey; and S. Raudenbush.) Racial and economic…

  15. "Talking Pictures Therapy" as Brief Therapy in a School Setting

    Science.gov (United States)

    Loewenthal, Del

    2013-01-01

    This article presents "talking pictures therapy" as an approach to brief therapy, in which photographs are used in brief psychotherapy and counseling with the purpose of enabling clients to express and explore through photographs aspects of their lives they would like to talk about. The author presents case examples using "talking pictures…

  16. Usability Briefing - a process model for healthcare facilities

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    2014-01-01

    briefing for hospitals”, where methods for capturing user needs and experiences at hospital facilities are investigated in order to feed into design processes and satisfy the users’ needs and maximise the effectiveness of facilities. Purpose: This paper introduces the concept of usability briefing...... and the purpose is to develop a process model for applying it on complex building projects. Usability briefing is a process in which users are actively involved, not only in evaluations and data gathering, but also in a continuous briefing process with focus on usability. Approach: The model is inductively...... developed from a literature review and three case studies at hospitals in Denmark and Norway. With the aim of connecting to practice, the steps in the model are based on RIBA’s planning phases from 2013. Results/ Originality: The paper presents an integrated usability briefing process model for continuous...

  17. Examining the Efficacy of a Brief Mindfulness-Based Stress Reduction (Brief MBSR) Program on Psychological Health

    Science.gov (United States)

    Bergen-Cico, Dessa; Possemato, Kyle; Cheon, Sanghyeon

    2013-01-01

    Objective: The purpose of the study was to examine potential psychological health benefits of participating in a brief (5-week) mindfulness-based stress reduction (brief MBSR) program integrated into an academic course. Participants: Participants were 119 undergraduate students (treatment: "n" = 72; control: "n" = 47) enrolled…

  18. What does "brief" mean? A theoretical critique of the concept of brief therapy from a psychoanalytic viewpoint.

    Science.gov (United States)

    Migone, Paolo

    2014-08-01

    The concept of "brief therapy" contains internal contradictions. The techniques suggested by brief therapists are the same techniques that have been discussed historically in debates on theory of technique, both within and without psychoanalysis (e.g., the experiential factor at the center of the Freud-Ferenczi confrontation is also an important aspect of Gestalt therapy). A time limit is the only operational criterion that allows a rigorous definition of brief therapy; without this criterion it is impossible to discriminate between "brief" and simply "good" therapies (i.e., those in which patients are successfully treated in a short time). An important question is why, with a given patient, a therapist should decide, a priori, to terminate a treatment within a set time. Two clinical examples are presented, illustrating the usefulness of Eissler's concept of parameters as a heuristic framework to identify the potentially defensive nature of both "brief" and "long-term" therapy.

  19. What does "brief" mean? A theoretical critique of the concept of brief therapy from a psychoanalytic viewpoint.

    Science.gov (United States)

    Migone, Paolo

    2014-08-01

    The concept of "brief therapy" contains internal contradictions. The techniques suggested by brief therapists are the same techniques that have been discussed historically in debates on theory of technique, both within and without psychoanalysis (e.g., the experiential factor at the center of the Freud-Ferenczi confrontation is also an important aspect of Gestalt therapy). A time limit is the only operational criterion that allows a rigorous definition of brief therapy; without this criterion it is impossible to discriminate between "brief" and simply "good" therapies (i.e., those in which patients are successfully treated in a short time). An important question is why, with a given patient, a therapist should decide, a priori, to terminate a treatment within a set time. Two clinical examples are presented, illustrating the usefulness of Eissler's concept of parameters as a heuristic framework to identify the potentially defensive nature of both "brief" and "long-term" therapy. PMID:25049047

  20. Briefing highlights space weather risks to GPS

    Science.gov (United States)

    Tretkoff, Ernie

    2011-07-01

    Solar storms, which are expected to increase as the Sun nears the most active phase of the solar cycle, can disrupt a variety of technologies on which society relies. Speakers at a 22 June briefing on Capitol Hill in Washington, D. C., focused on how space weather can affect the Global Positioning System (GPS), which is used in a wide range of industries, including commercial air travel, agriculture, national security, and emergency response. Rocky Stone, chief technical pilot for United Airlines, noted that GPS allows more aircraft to be in airspace, saves fuel, and helps aircraft move safely on runways. “Improvements in space weather forecasting need to be pursued,” he said. Precision GPS has also “changed the whole nature of farming,” said Ron Hatch, Director of Navigation Systems, NavCom Technology/John Deere. GPS makes it possible for tractors to be driven in the most efficient paths and for fertilizer and water to be applied precisely to the areas that most need them. Space weather-induced degradation of GPS signals can cause significant loss to farms that rely on GPS. Elizabeth Zimmerman, Deputy Associate Administrator for the Office of Response and Recovery at the Federal Emergency Management Agency (FEMA), described how FEMA relies on GPS for disaster recovery. The agency is developing an operations plan for dealing with space weather, she said.

  1. Market Brief : Turkey oil and gas pipelines

    International Nuclear Information System (INIS)

    This report presented some quick facts about oil and gas pipelines in Turkey and presented opportunities for trade. The key players and customers in the oil and gas sector were described along with an export check list. Turkey is looking into becoming an energy bridge between oil and gas producing countries in the Middle East, Central Asia and Europe. The oil and gas sectors are dominated by the Turkish Petroleum Corporation, a public enterprise dealing with exploration and production, and the State Pipeline Corporation which deals with energy transmission. They are also the key buyers of oil and gas equipment in Turkey. There are several pipelines connecting countries bordering the Caspian Sea. Opportunities exist in the areas of engineering consulting as well as contracting services for oil and gas pipeline transmission and distribution. Other opportunities lie in the area of pipeline construction, rehabilitation, materials, equipment, installation, and supervisory control and data acquisition (SCADA) systems. Currently, the major players are suppliers from Italy, Germany, France, United States and Japan. Turkey has no trade barriers and imported equipment and materials are not subjected to any restriction. The oil and gas market in Turkey expected in increase by an average annual growth rate of 15 per cent from 2001 to 2003. A brief description of pipeline projects in Turkey was presented in this report along with a list of key contacts and support services. 25 refs., 1 append

  2. A Brief History of Black Holes

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2006-04-01

    Full Text Available Neither the layman nor the specialist, in general, have any knowledge of the historical circumstances underlying the genesis of the idea of the Black Hole. Essentially, almost all and sundry simply take for granted the unsubstantiated allegations of some ostentatious minority of the relativists. Unfortunately, that minority has been rather careless with the truth and is quite averse to having its claims corrected, notwithstanding the documentary evidence on the historical record. Furthermore, not a few of that vainglorious and disingenuous coterie, particularly amongst those of some notoriety, attempt to dismiss the testimony of the literature with contempt, and even deliberate falsehoods, claiming that history is of no importance. The historical record clearly demonstrates that the Black Hole has been conjured up by combination of confusion, superstition and ineptitude, and is sustained by widespread suppression of facts, both physical and theoretical. The following essay provides a brief but accurate account of events, verifiable by reference to the original papers, by which the scandalous manipulation of both scientific and public opinion is revealed

  3. A Brief History of Black Holes

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2006-04-01

    Full Text Available Neither the layman nor the specialist, in general, have any knowledge of the historical circumstances underlying the genesis of the idea of the Black Hole. Essentially, almost all and sundry simply take for granted the unsubstantiated allegations of some ostentatious minority of the relativists. Unfortunately, that minority has been rather careless with the truth and is quite averse to having its claims corrected, notwithstanding the documentary evidence on the historical record. Furthermore, not a few of that vainglorious and disingenuous coterie, particularly amongst those of some notoriety, attempt to dismiss the testimony of the literature with contempt, and even deliberate falsehoods, claiming that history is of no importance. The historical record clearly demonstrates that the Black Hole has been conjured up by combination of confusion, superstition and ineptitude, and is sustained by widespread suppression of facts, both physical and theoretical. The following essay provides a brief but accurate account of events, verifiable by reference to the original papers, by which the scandalous manipulation of both scientific and public opinion is revealed.

  4. History of Hanford Site Defense Production (Brief)

    Energy Technology Data Exchange (ETDEWEB)

    GERBER, M S

    2001-02-01

    This paper acquaints the audience with the history of the Hanford Site, America's first full-scale defense plutonium production site. The paper includes the founding and basic operating history of the Hanford Site, including World War II construction and operations, three major postwar expansions (1947-55), the peak years of production (1956-63), production phase downs (1964-the present), a brief production spurt from 1984-86, the end of the Cold War, and the beginning of the waste cleanup mission. The paper also delineates historical waste practices and policies as they changed over the years at the Hanford Site, past efforts to chemically treat, ''fractionate,'' and/or immobilize Hanford's wastes, and resulting major waste legacies that remain today. This paper presents original, primary-source research into the waste history of the Hanford Site. Finally, the paper places the current Hanford Site waste remediation endeavors in the broad context of American and world history.

  5. Legal briefing: organ donation and allocation.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2010-01-01

    This issue's "Legal Briefing" column covers legal developments pertaining to organ donation and allocation. This topic has been the subject of recent articles in JCE. Organ donation and allocation have also recently been the subjects of significant public policy attention. In the past several months, legislatures and regulatory agencies across the United States and across the world have changed, or considered changing, the methods for procuring and distributing human organs for transplantation. Currently, in the U.S., more than 100,000 persons are waiting for organ transplantation. In China, more than 1.5 million people are waiting. Given the chronic shortage of available organs (especially kidneys and livers) relative to demand, the primary focus of most legal developments has been on increasing the rate of donation. These and related developments are usefully divided into the following 12 topical categories: 1. Revised Uniform Anatomical Gift Act. 2. Presumed Consent and Opt-Out. 3. Mandated Choice. 4. Donation after Cardiac Death. 5. Payment and Compensation. 6. Donation by Prisoners. 7. Donor Registries. 8. Public Education. 9. Other Procurement Initiatives. 10. Lawsuits and Liability. 11. Trafficking and Tourism. 12. Allocation and Distribution. PMID:21089996

  6. Market brief : natural gas in Turkey

    International Nuclear Information System (INIS)

    Turkey may soon become an important transit route to Europe for natural gas imported from the Caucasus, Iran, and other Middle Eastern countries. This market brief provided an overview of Turkey's natural gas market and industry, and examined investment and business opportunities for Canadian businesses. Consumption of natural gas in Turkey has grown by 14.8 per cent annually in the last decade. Transmission equipment expenditures total approximately $400 million annually. It is expected that the demand for environmental and engineering services for natural gas-related industries will grow by 15 per cent annually over the next decade. There are currently several opportunities for Canadian suppliers of equipment, engineering, and construction services. Turkey's expected full European Union (EU) membership will require Turkey to adopt EU environmental and emissions standards. Potential investors in Turkey require operating licences from Turkey's Energy Market Regulatory Authority (EMRA). All state procurement is by tender, while BOTAS, the state-owned gas company dominates both imports and the transmission of gas. Market entry considerations were also presented. 7 refs., 4 tabs., 2 figs

  7. Hubble Space Telescope Briefing: HST Science Overview

    Science.gov (United States)

    1994-01-01

    This NASA Kennedy Space Center video release presents a broad overview of the science that is now possible as a result of the servicing of the Hubble Space Telescope (HST). Dr. Ed Weiler (HST Program Scientist, NASA Headquarters), Dr. Dave Leckrone (HST, Senior Project Scientist, Goddard Space Flight Center (GSFC)), Dr. John Trauger (Wide Field Planetary Camera 2 (WFPC2) Principal Investigator, Jet Propulsion Lab. (JPL)), Dr. Chris Burrows (WFPC2 Co-Investigator, Space Telescope Science Inst.(STSci)-European Space Agency (ESA), Jim Crocker ((Corrective Optics Space Telescope Axial Replacement) COSTAR Team Leader, STSci), Dr. Holland Ford (COSTAR Project Scientist, Johns Hopkins Univ., STSci), and Dr. Duccio Machetto (European Space Agency (ESA)) give brief presentations, which feature images of stars and galaxies taken from the ground, from WFPC1 (prior to the servicing mission), and from WFPC2 (after the servicing mission). The main theme of the discussions center around the spherical aberration that was found in the images prior to servicing and the corrected images seen without the aberration following servicing. A question and answer period rounds out the press conference, with questions posed from scientific journalists at GSFC and other NASA centers.

  8. A brief history of mathematics in finance

    Directory of Open Access Journals (Sweden)

    Erdinç Akyıldırım

    2014-03-01

    Full Text Available In the list of possible scapegoats for the recent financial crises, mathematics, in particular mathematical finance has been ranked, without a doubt, as the first among many and quants, as mathematicians are known in the industry, have been blamed for developing and using esoteric models which are believed to have caused the deepening of the financial crisis. However, as Lo and Mueller (2010 state “Blaming quantitative models for the crisis seems particularly perverse, and akin to blaming arithmetic and the real number system for accounting fraud.” Throughout the history, mathematics and finance have always been in a close relationship. Starting from Babylonians, through Thales, and then Fibonacci, Pascal, Fermat, Bernoulli, Bachelier, Wiener, Kolmogorov, Ito, Markowitz, Black, Scholes, Merton and many others made huge contributions to the development of mathematics while trying to solve finance problems. In this paper, we present a brief historical perspective on how the development of finance theory has influenced and in turn been influenced by the development of mathematical finance theory.

  9. Sustainable Markets Investment Briefings: the regulatory taking doctrine

    Energy Technology Data Exchange (ETDEWEB)

    Cotula, Lorenzo

    2007-08-15

    This is the third of a series of briefings which discuss the sustainable development issues raised by legal arrangements for the protection of foreign investment. The briefings are based on legal research by IIED and its partners. The goal is to provide accessible but accurate information for human rights, development and environmental organisations working on issues raised by foreign investment in low- and middle-income countries. Briefing 3 introduces one of the most controversial legal doctrines of investment law – 'regulatory taking' – and sets out its implications for sustainable development.

  10. Issue briefs on low-level radioactive wastes

    International Nuclear Information System (INIS)

    This report contains 4 Issue Briefs on low-level radioactive wastes. They are entitled: Handling, Packaging, and Transportation, Economics of LLW Management, Public Participation and Siting, and Low Level Waste Management

  11. FREE Policy Brief No. 3 - Women's Football and Female Fans

    OpenAIRE

    Pfister, Gertrud Ursula; Sonntag, Albrecht; Ranc, David

    2015-01-01

    Football Research in an Enlarged Europe (FREE).This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football.

  12. Brief Guide to Genomics: DNA, Genes and Genomes

    Science.gov (United States)

    ... de genómica A Brief Guide to Genomics DNA, Genes and Genomes Deoxyribonucleic acid (DNA) is the chemical ... needed to build the entire human body. A gene traditionally refers to the unit of DNA that ...

  13. Interpretation: bridge of cultures--A brief introduction to interpretation

    Institute of Scientific and Technical Information of China (English)

    袁立梅

    2005-01-01

    This essay gives a brief introduction to interpretation in term of its definition, characteristics, criteria and classification, providing an overall view to this increasingly widely used communication vehicle in today's society.

  14. Mindfulness meditation improves cognition: evidence of brief mental training.

    Science.gov (United States)

    Zeidan, Fadel; Johnson, Susan K; Diamond, Bruce J; David, Zhanna; Goolkasian, Paula

    2010-06-01

    Although research has found that long-term mindfulness meditation practice promotes executive functioning and the ability to sustain attention, the effects of brief mindfulness meditation training have not been fully explored. We examined whether brief meditation training affects cognition and mood when compared to an active control group. After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.

  15. Center for Information Systems Research Research Briefings 2002

    OpenAIRE

    Ross, Jeanne W.

    2003-01-01

    This paper is comprised of research briefings from the MIT Sloan School of Management's Center for Information Systems Research (CISR). CISR's mission is to perform practical empirical research on how firms generate business value from IT.

  16. PROGRESSES IN IONOSPHERIC RESEARCH, 2000-2002: A BRIEF REVIEW

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This brief report reviews the recent developments in ionospheric physics studies made by Chinese scientists. It covers areas from the numerical simulations and theoretical researches on ionospheric properties, ionospheric disturbances, space weather events in the ionosphere to ionospheric obserwtions.

  17. A brief examination of optical tagging technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Mark R.; Cahill, Paul A. (Aspecular Optics, Dayton, OH); Drummond, Timothy J.; Wilcoxon, Jess Patrick

    2003-07-01

    Presented within this report are the results of a brief examination of optical tagging technologies funded by the Laboratory Directed Research and Development (LDRD) program at Sandia National Laboratories. The work was performed during the summer months of 2002 with total funding of $65k. The intent of the project was to briefly examine a broad range of approaches to optical tagging concentrating on the wavelength range between ultraviolet (UV) and the short wavelength infrared (SWIR, {lambda} < 2{micro}m). Tagging approaches considered include such things as simple combinations of reflective and absorptive materials closely spaced in wavelength to give a high contrast over a short range of wavelengths, rare-earth oxides in transparent binders to produce a narrow absorption line hyperspectral tag, and fluorescing materials such as phosphors, dies and chemically precipitated particles. One technical approach examined in slightly greater detail was the use of fluorescing nano particles of metals and semiconductor materials. The idea was to embed such nano particles in an oily film or transparent paint binder. When pumped with a SWIR laser such as that produced by laser diodes at {lambda}=1.54{micro}m, the particles would fluoresce at slightly longer wavelengths, thereby giving a unique signal. While it is believed that optical tags are important for military, intelligence and even law enforcement applications, as a business area, tags do not appear to represent a high on return investment. Other government agencies frequently shop for existing or mature tag technologies but rarely are interested enough to pay for development of an untried technical approach. It was hoped that through a relatively small investment of laboratory R&D funds, enough technologies could be identified that a potential customers requirements could be met with a minimum of additional development work. Only time will tell if this proves to be correct.

  18. [Brief psychotherapy in clinical medicine patients].

    Science.gov (United States)

    Knobel, M

    1992-01-01

    The criteria that "illness is biographical crisis od the individual" and that the only medicine is "personal medicine" is stressed. Clinical medicine, which covers medicine in its entirety, demands conceptual and doctrinal reaffirmations so that gradually the patient can come to be dealt with as a human being fron a holistic point of view, which commences with his complaint and consultation, continues with the interview and semiology, to finish with the diagnosis and therapy which, although in some cases it may be surgical, is still medical and integral. All the steps mentioned are bio-socio-cultural thus, whether in the practice of general clinical medicine or in the most specialized and technologically sophisticated clinical medicine, the animist component is not lacking and demands a minimum degree of "psychosomatic" Knowledge. The use of a psychotherapeutic technique is proposed which, while based on the psychoanalysis theory, is distanced technically from it as a "psychotherapy on limited time and goals", which abbreviates the disease, and is projected not as the "focus" of therapeutic work, but as a re-evaluation of the "life style" of each individual, and tends to help to develop a "project for life" suited to the possible personal, familiar and social well-being of the "patient". Technically speaking, this modality of brief psychotherapy is based on the nonuse of transferential interpretations, on impeding the regression od the patient, on facilitating a cognitice-affective development of his conflicts and thus obtain an internal object mutation which allows the transformation of the "past" into true history, and the "present" into vital perspectives. This technique is within reach of every health professional.

  19. FREE Policy Brief No. 3 - Women's Football and Female Fans

    DEFF Research Database (Denmark)

    Pfister, Gertrud Ursula; Sonntag, Albrecht; Ranc, David

    2015-01-01

    Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football.......Football Research in an Enlarged Europe (FREE). This is the third of three policy briefs based on findings from the FREE project. It summarises results from the project's research stream on the feminisation of football....

  20. Tips for Conducting the Pre-Brief for a Simulation.

    Science.gov (United States)

    Stephenson, Evelyn; Poore, Julie

    2016-08-01

    The pre-brief is an important part of a simulation. It offers participants an orientation to the simulation environment and enables them to reach the intended goals and objectives of the learning activity. This article describes the components of the pre-brief and provides practical tips on how to conduct this step using a simulation. These teaching strategies will help provide a positive learning experience for participants. J Contin Educ Nurs. 2016;47(8):353-355. PMID:27467309

  1. Brief interventions for illicit drug use among peripartum women.

    Science.gov (United States)

    Farr, Sherry L; Hutchings, Yalonda L; Ondersma, Steven J; Creanga, Andreea A

    2014-10-01

    We review the evidence and identify limitations of the current literature on the effectiveness of brief interventions (≤5 intervention sessions) on illicit drug use, treatment enrollment/retention, and pregnancy outcomes among pregnant and postpartum women; and consider this evidence in the context of the broader brief intervention literature. Among 4 published studies identified via systematic review and meeting a priori quality criteria, we found limited, yet promising evidence of the benefit of brief interventions to reduce illicit drug use among postpartum women. Two of the 4 randomized controlled trials tested similar computer-delivered single-session interventions; both demonstrate effects on postpartum drug use. Neither of the 2 randomized controlled trials that assessed treatment use found differences between intervention and control groups. Studies examining brief interventions for smoking and alcohol use among pregnant women, and for illicit drug use in the general adult population, have shown small but statistically significant results of the effectiveness of such interventions. Larger studies, those that examine the effect of assessment alone on illicit drug use, and those that use technology-delivered brief interventions are needed to assess the effectiveness of brief interventions for drug use in the peripartum period.

  2. A brief image-based prevention intervention for adolescents.

    Science.gov (United States)

    Werch, Chudley E Chad; Bian, Hui; Diclemente, Carlo C; Moore, Michelle J; Thombs, Dennis; Ames, Steven C; Huang, I-Chan; Pokorny, Steven

    2010-03-01

    The authors evaluated the efficacy of a brief image-based prevention intervention and assessed current drug use as a moderator of intervention effects. In a clinical trial, 416 high school-age adolescents were randomized to either the brief intervention or usual care control, with data collected at baseline and 3-month follow-up. The brief intervention consisted of a tailored in-person communication and a series of parent/guardian print materials based on the behavior-image model. Health behavior goal setting increased for participants receiving the brief intervention, with an effect size in the small range (d = 0.33). Overall effect sizes for cigarette smoking frequency and quantity and alcohol use frequency and quantity were small (ds = 0.16-0.21) and in favor of the brief intervention. However, adolescents reporting current substance use who received the brief intervention reduced their frequency and heavy use of alcohol, frequency and quantity of cigarette smoking, and reported fewer alcohol/drug problems, with larger effects ranging from small to approaching medium in size (ds = 0.32-0.43, ps goal setting and reduce substance use, particularly among drug-using older adolescents.

  3. Engine Development Design Margins Briefing Charts

    Science.gov (United States)

    Bentz, Chuck

    2006-01-01

    New engines experience durability problems after entering service. The most prevalent and costly is the hot section, particularly the high-pressure turbine. The origin of durability problems can be traced back to: 1) the basic aero-mechanical design systems, assumptions, and design margins used by the engine designers, 2) the available materials systems, and 3) to a large extent, aggressive marketing in a highly competitive environment that pushes engine components beyond the demonstrated capability of the basic technology available for the hardware designs. Unfortunately the user must operate the engine in the service environment in order to learn the actual thrust loading and the time at max effort take-off conditions used in service are needed to determine the hot section life. Several hundred thousand hours of operational service will be required before the demonstrated reliability of a fleet of engines or the design deficiencies of the engine hot section parts can be determined. Also, it may take three to four engine shop visits for heavy maintenance on the gas path hardware to establish cost effective build standards. Spare parts drive the oerator's engine maintenance costs but spare parts also makes lots of money for the engine manufacturer during the service life of an engine. Unless competition prevails for follow-on engine buys, there is really no motivation for an OEM to spend internal money to improve parts durability and reduce earnings derived from a lucrative spare parts business. If the hot section life is below design goals or promised values, the OEM migh argue that the engine is being operated beyond its basic design intent. On the other hand, the airframer and the operator will continue to remind the OEM that his engine was selected based on a lot of promises to deliver spec thrust with little impact on engine service life if higher thrust is used intermittently. In the end, a standoff prevails and nothing gets fixed. This briefing will propose

  4. Global Green New Deal. Policy Brief

    International Nuclear Information System (INIS)

    The 'Global Green New Deal' (GGND) presented here has three broad objectives. It should make a major contribution to reviving the world economy, saving and creating jobs, and protecting vulnerable groups. It should promote sustainable and inclusive growth and the achievement of the MDGs, especially ending extreme poverty by 2015. Also, it must reduce carbon dependency and ecosystem degradation. These are key risks along a path to a sustainable world economy. Our consultations and our commissioned research, summarized here in this Policy Brief, make a strong case for the active 'greening' of proposed fiscal stimulus packages. However, this must also be backed by necessary changes in international and domestic policy architectures, as the current framework is biased in favour of resurrecting an unsustainable 'brown economy'. Our proposals are therefore grouped under three categories - targeted stimulus spending in 2009-10, changes in domestic policies, and changes in international policy architecture. Furthermore, we recognize that many less developed countries do not have the resources of their own and will have to rely on foreign aid and support, both financial and non-financial. We propose that the fiscal stimulus (to be applied over 2009 and 2010) should prioritize energy efficient buildings and investments in sustainable transport and renewable energy. Developing countries should prioritize investment in agricultural productivity measures, freshwater management, and sanitation, as these have demonstrable and exceptional social returns. Domestic policy reforms are recommended to substantially reduce perverse subsidies (eg: fossil fuels) and instead to create positive incentives and appropriate taxes which will encourage a greener economy. Domestic reforms should also address some common issues in land use and urban policy. Integrated management of freshwater would also require some domestic policy changes, and this should be prioritized by developing countries

  5. Zora’s Politics: A Brief Introduction

    Directory of Open Access Journals (Sweden)

    Ernest Julius Mitchell II

    2013-09-01

    Full Text Available In his introduction to reading Zora Neale Hurston’s politics, Mitchell argues that contemporary scholarship has misread Hurston in significant ways, distorting Hurston’s work and reputation to serve contesting political agendas; thus, in recent years, she has been associated with “a bewildering array of affiliations: republican, libertarian, radical democrat, reactionary conservative, black cultural nationalist, anti-authoritarian feminist, and woman-hating protofascist.” Recuperating Hurston from this impossible political melee of labels, Mitchell argues, requires a careful reading of Hurston’s work dating from her earliest pieces in the late 1920s, as well as surveying her many yet to be published manuscripts and letters; it requires recognition of the transnational and comparative lens through which she reported on political maneuvers and military histories, as well as reading not only her strong criticisms but also her silences, ironic phrasings, and nuanced critiques in her writings on global colonial enterprises. Mitchell’s introduction to the two Hurston essays here reprinted, “I Saw Negro Votes Peddled” (1950 and “Why the Negro Won’t Buy Communism” (1951—courtesy of the American Legion Magazine—is set in the larger frame of his assertion that Hurston’s work should be read with a deep appreciation of her staunch anticolonialism. Tracing her political philosophy through her views of how race and religion are used to valorize an international culture of violence that serves imperialistic and colonial ends, Mitchell takes his reader on a tour of Hurston’s transnational commentary—from the US occupation of Haiti, to the Spanish and British on the Florida peninsula; from Communist Russia and China, to election practices in the US—to set the stage for our encounters with these rarely read Hurston essays. Reading Mitchell’s “Zora’s Politics: A Brief Introduction” provides a firm foundation for a more

  6. Multi-service briefing on radioisotope systems for defense applications, briefing notes and supporting information

    Energy Technology Data Exchange (ETDEWEB)

    Jarrett, J.H.; Tingey, G.L.

    1990-05-01

    A briefing on isotope systems technology and applications was held at the Pentagon on 9 May 1990, cosponsored by the Department of Defense and the Department of Energy. The objective was to provide isotope systems information to interested individuals and offices from the DOD and the Services, and then to discuss potential uses of this technology within the defense community. Presentations were given on the useful characteristics of radioactive decay, isotope sources, properties of specific isotopes, and details of isotope systems that have been deployed for terrestrial and space applications. Application areas covered included: electrical, thermal and mechanical energy conversion systems; radiation applications; and radioluminescent lights. Talks were also given on system licensing and approvals, and conclusions from the 1986 workshop on isotope systems applications. This document contains the meeting agenda, copies of the vu-graphs used in the presentations, face sheets given to meeting attendees, a list of attendees, and supplementary information requested during the meeting.

  7. STS-114: Discovery Crew Post Landing Press Briefing

    Science.gov (United States)

    2005-01-01

    The crew of the STS-114 Discovery is shown during a post landing press briefing. Commander Collins introduces the crew members who consist of Pilot Jim Kelley, Mission Specialist Soichi Noguchi from JAXA, Steve Robinson, Mission Specialist and Charlie Camarda, Mission Specialist. Steve Robinson answers a question from the news media about the repair that he performed in orbit, and his feelings about being back in his hometown of California. Commander Collins talks about the most significant accomplishment of the mission. The briefing ends as each crewmember reflects on the Space Shuttle Columbia tragedy and expresses their personal thoughts and feelings as they re-entered the Earth's atmosphere.

  8. Theoretical development of information science: A brief history

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2016-01-01

    This paper presents a brief history of information science (IS) as viewed by the author. The term ‘information science’ goes back to 1955 and evolved in the aftermath of Claude Shannon’s ‘information theory’ (1948), which also inspired research into problems in fields of library science and docum......This paper presents a brief history of information science (IS) as viewed by the author. The term ‘information science’ goes back to 1955 and evolved in the aftermath of Claude Shannon’s ‘information theory’ (1948), which also inspired research into problems in fields of library science...

  9. Renewable energy. From marginal to mainstream. Policy Brief

    Energy Technology Data Exchange (ETDEWEB)

    Veum, K.C.; Uslu, A.; De Coninck, H.C. [ECN Policy Studies, Petten (Netherlands)

    2013-04-15

    This policy brief aims to instigate a debate on the broader enabling conditions required to move renewable energy from marginal shares in the European energy system to a mainstream role. It does so by posing seven key questions related to public movement, the political-industrial complex, resources and sustainability, grids and markets, finance, legal procedures and overall policy. These questions require short- to medium-term attention to keep a long-term renewable energy system within the realm of possibilities. This policy brief also provides ECN's initial reflections on how these key questions could be addressed, and indicates which relevant expertise it can bring to the table.

  10. Paroxetine in the treatment of recurrent brief depressive disorder

    Directory of Open Access Journals (Sweden)

    Sathya Prakash

    2013-01-01

    Full Text Available Recurrent brief depressive disorder is now a well-recognized type of depressive disorder. However, there is still no clear evidence base for its treatment. The efficacy of several drugs including antidepressants and mood stabilizers in this disorder has been controversial. Methodological limitations need to be considered when interpreting the results of studies on efficacy of drugs in this disorder. We report a case of recurrent brief depressive disorder that responded dramatically to paroxetine. However, there is a need for larger, methodologically sound, double-blind, placebo-controlled studies.

  11. The efficacy of a brief group CBT program in treating patients diagnosed with bulimia nervosa: a brief report

    DEFF Research Database (Denmark)

    Jones, Allan; Clausen, Loa

    2013-01-01

    OBJECTIVE: The aim of the study was to evaluate the efficacy of a brief group cognitive behavior therapy (CBT) program in treating a large cohort of patients diagnosed with bulimia nervosa. METHOD: Treatment outcome defined as reductions in bulimia related behavioral symptoms and bulimia related...... distress was examined in 205 consecutive new patients enrolled in an eight-session group CBT program. RESULTS: Significant reductions in eating disorder pathology were found on all measures of bulimia related behavioral symptoms, as well as on all measures of bulimia related distress. DISCUSSION......: There is strong evidence for the efficacy of brief group CBT in treating patients with bulimia nervosa....

  12. A NASA Recipe for Protein Crystallography. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing protein crystals. Protein crystals can be very difficult to grow. This activity for grades 9-12 provides a simple recipe for growing protein crystals from Brazil nuts. Included are a history of protein crystals, a discussion of microgravity effects on growth, connections to academic standards, and lab sheets. (MVL)

  13. Every Child Every Promise Workforce Readiness. Issue Brief

    Science.gov (United States)

    America's Promise Alliance (NJ1), 2007

    2007-01-01

    The third "Every Child, Every Promise" research brief focuses on the large percentage of the children and youth who will enter the workforce over the next two decades are lacking enough of the "soft" or applied skills--such as teamwork, decision-making, and communication--that will help them become effective employees and managers. The report…

  14. Toys in Physics Lectures and Demonstrations--A Brief Review

    Science.gov (United States)

    Guemez, J.; Fiolhais, C.; Fiolhais, M.

    2009-01-01

    The use of toys in physics teaching is common. This brief review of the physics of toys intends to show that they are not only very useful in lectures and demonstrations in order to motivate students but also very interesting from a scientific point of view. However, since their physics is sometimes too cumbersome, the effect can be the opposite.…

  15. Validation of the Marijuana Effect Expectancy Questionnaire-Brief

    Science.gov (United States)

    Torrealday, O.; Stein, L. A. R.; Barnett, N.; Golembeske, C.; Lebeau, R.; Colby, S. M.; Monti, P. M.

    2008-01-01

    The purpose of this study was to evaluate a brief version of the Marijuana Effect Expectancy Questionnaire (MEEQ; Schafer & Brown, 1991). The original MEEQ was reduced to 6 items (MEEQ-B). Principal component analysis (PCA) was performed and two factors were identified (positive effects and negative effects) accounting for 52.3% of the variance.…

  16. 76 FR 44373 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2011-07-25

    ... From the Federal Register Online via the Government Publishing Office MERIT SYSTEMS PROTECTION BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board (MSPB or Board... National Association of Letter Carriers, Case No. G06N-4G-C 10205542 (2011) (Sherman, Arb.); In...

  17. Brief Family Counseling Intervention: Cibola Cluster, 1997-98.

    Science.gov (United States)

    Mearns, Curt

    This evaluation focuses on the effectiveness of the brief family counseling intervention component of a school-based comprehensive program. Assessment was based upon increased attendance rates; decreased suspension at secondary schools; decreased number of violent incidents; increased number of students receiving mental health services; and…

  18. Advancing Prediction of Foster Placement Disruption Using Brief Behavioral Screening

    Science.gov (United States)

    Hurlburt, Michael S.; Chamberlain, Patricia; DeGarmo, David; Zhang, Jinjin; Price, Joe M.

    2010-01-01

    Objective: Behavioral difficulties increase the risk that children will experience negative placement disruptions while in foster care. Chamberlain et al. (2006) found that the Parent Daily Report (PDR), a brief measure of parent-reported child behaviors, was a strong predictor of negative placement changes over 1 year among children receiving…

  19. Brief Adlerian psychodynamic psychotherapy: theoretical issues and process indicators.

    Science.gov (United States)

    Fassino, S; Amianto, F; Ferrero, A

    2008-06-01

    Brief psychotherapy is gaining interest worldwide, because of its good cost/effectiveness ratio and proved efficacy. The aim of the paper was to describe the brief Adlerian psychodynamic psychotherapy (B-APP): a brief, psychodynamically oriented psychotherapy referring to the individual psychology (IP). The B-APP theory refers to the following paradigms: 1) the individual represents a psychosomatic unity integrated in the social context; 2) the individual needs to build and regulate the image of the self; 3) bond patterns regulate human relationships and represent the symbolic ''fil rouge'' connecting the elements of the life-style. Its objectives are: 1) an at least partial resolution of the focus problem; 2) a decrease or a non-increase of symptoms; 3) a global increase of quality of life. The results depend on intrapsychic and relational changes. Indications are more relative than absolute. The possibility of identifying a meaningful focus is fundamental. The treatment scheme includes 15 sessions subdivided into 5 phases. B-APP offers a technical approach to brief psychotherapy which is suitable in many fields of psychiatry and liaison medicine such as preventive interventions in at-risk subjects, somatopsychic disorders and liaison psychiatry, personality and eating disorders, and treatment of emotionally disturbed children. It was applied as psychotherapeutic approach in some clinical outcome studies about eating disorders and severe personality disorders displaying a good efficacy.

  20. A brief history of the Nuclear Physics Board

    International Nuclear Information System (INIS)

    This year the Nuclear Physics Board of the Science and Engineering Research Council ceases to exist. To mark its passing, a brief retrospective is presented of the organization that for nearly 30 years has supported fundamental research into the nature of matter, in the United Kingdom. (author)

  1. Perception of time under conditions of brief weightlessness

    Science.gov (United States)

    Lebedev, V. I.; Chekidra, I. F.; Kolosov, I. A.

    1975-01-01

    Results of experiments under conditions of brief weightlessness confirmed the theoretical concepts of the dependence of time perception on the emotional state of a man. The time test, together with other methods, can be used to precisely define the emotional state of subjects in stress situations.

  2. A validation study of the Brief Irrational Thoughts Inventory

    NARCIS (Netherlands)

    L.M. Hoogsteder; I.B. Wissink; G.J.J.M. Stams; J.E. van Horn; J. Hendriks

    2014-01-01

    This study examines the reliability and validity of the "Brief Irrational Thoughts Inventory" (BITI) in a sample of 256 justice-involved youths. The BITI is a questionnaire used to determine the nature and severity of irrational thoughts related to aggressive (externalizing), sub-assertive (internal

  3. Eye Tracking: A Brief Guide for Developmental Researchers

    Science.gov (United States)

    Feng, Gary

    2011-01-01

    Eye tracking offers a powerful research tool for developmental scientists. In this brief article, the author introduces the methodology and issues associated with its applications in developmental research, beginning with an overview of eye movements and eye-tracking technologies, followed by examples of how it is used to study the developing mind…

  4. Implementing No Child Left Behind in Three States. Research Brief

    Science.gov (United States)

    Stecher, Brian M.; Epstein, Scott; Hamilton, Laura S.; Marsh, Julie A.; Robyn, Abby; McCombs, Jennifer Sloan; Russell, Jennifer; Naftel, Scott

    2008-01-01

    This research brief describes work done for RAND Education and documented in "Pain and Gain: Implementing No Child Left Behind in Three States, 2004-2006", Brian M. Stecher, Scott Epstein, Laura S. Hamilton, Julie A. Marsh, Abby Robyn, Jennifer Sloan McCombs, Jennifer Russell, and Scott Naftel." The three states discussed are: California, Georgia,…

  5. Language of Instruction: Choices and Consequences. PREL Briefing Paper.

    Science.gov (United States)

    Simanu-Klutz, Fata

    This briefing paper focuses on the choices of instructional language in Pacific classrooms, as mandated by national or state policies, and discusses consequences of such choices on students' academic achievement and career preparation in the changing Pacific region. The paper first notes that in most South Pacific secondary schools, English is the…

  6. Response to Intervention and English Learners. CREATE Brief

    Science.gov (United States)

    Echevarria, Jana; Hasbrouck, Jan

    2009-01-01

    Response to Intervention (RTI) has emerged as a method for providing early academic assistance to students with difficulty learning. This brief outlines the tiered structure of RTI and how it can be implemented as an effective technique for teaching English learners who are having difficulty making academic progress. It touches on methods of…

  7. NASA's Bioreactor: Growing Cells in a Microgravity Environment. Educational Brief.

    Science.gov (United States)

    National Aeronautics and Space Administration, Washington, DC.

    This brief discusses growing cells in a microgravity environment for grades 9-12. Students are provided with plans for building a classroom bioreactor that can then be used with the included activity on seed growth in a microgravity environment. Additional experimental ideas are also suggested along with a history and background on microgravity…

  8. Assessment and Accountability across the 50 States. CPRE Policy Briefs.

    Science.gov (United States)

    Goertz, Margaret E.; Duffy, Mark C.

    This policy brief summarizes a longer report about state assessment and accountability systems in all 50 states. It examines the extent to which state policies meet the intent of federal policy, particularly Title I programs. It asks, "How are states measuring student performance and reporting it to the general public?" and "How are states holding…

  9. A Brief Introduction of the History of Linguistics

    Institute of Scientific and Technical Information of China (English)

    王非男

    2015-01-01

    Linguistics is generally defined as the scientific study of language. When it comes to the history of linguistics, it must be related to the origin of human language. This paper will give a brief introduction of the history of linguistics in Ancient Times and in the Middle Ages.

  10. A Brief Introduction to Foreign Languages Education Policy in China

    Science.gov (United States)

    Zhang, Weiwen

    2012-01-01

    Based on a series of official published documents and relevant research reports, the paper make a brief introduction to foreign languages education policies in China, which included national English teaching guidance, national English language textbooks, national English curriculum standard and the massive English teachers training program, etc.…

  11. Longitudinal Construct Validity of Brief Symptom Inventory Subscales in Schizophrenia

    Science.gov (United States)

    Long, Jeffrey D.; Harring, Jeffrey R.; Brekke, John S.; Test, Mary Ann; Greenberg, Jan

    2007-01-01

    Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times…

  12. A brief review of biomedical sensors and robotics sensors

    OpenAIRE

    Yanli Luo; , Qiaoying Zhou; Wenbin Luo

    2016-01-01

    In this paper, we present a brief review of biomedical sensors and robotics sensors. More specifically, we will review the cochlear sensors and retinal sensors in the category of biomedical sensors and ultrasonic Sensors and infrared motion detection sensors in the category of robotic sensors. Our goal is to familiarize readers with the common sensors used in the fields of both biom

  13. Initial Educational Experiences of Tertiary Students. LSAY Briefing Number 14

    Science.gov (United States)

    Hillman, Kylie

    2008-01-01

    This "Briefing" presents information about the initial tertiary education experiences, such as satisfaction with aspects of student life and changes to initial enrolments, of two groups of young people, based on two recent Longitudinal Surveys of Australian Youth (LSAY) research reports. One study focused on the first year experiences of a group…

  14. Physiological effects after exposure to heat : A brief literature review

    NARCIS (Netherlands)

    Bogerd, C.P.; Daanen, H.A.M.

    2011-01-01

    Many employees are exposed to heat stress during their work. Although the direct effects of heat are well reported, the long term physiological effects occurring after heat exposure are hardly described. The present manuscript addresses these issues in the form of a brief literature review. Repeated

  15. Counselor Interventions Preceding Client Laughter in Brief Therapy.

    Science.gov (United States)

    Falk, Dana R.; Hill, Clara E.

    1992-01-01

    Examined whether 6 categories of counselor humor and 4 categories of risk interventions preceded client laughter in 236 events from 8 cases of brief psychotherapy. Found most client laughter was mild and moderate, with only eight instances of strong laughter. Humorous interventions led to more client laughter than did interventions that encouraged…

  16. Effects of Therapist Response Modes in Brief Psychotherapy.

    Science.gov (United States)

    Hill, Clara E.; And Others

    1988-01-01

    Examined therapist response modes in 127 sessions of eight cases of brief psychotherapy with experienced therapists and anxious-depressed clients. Response modes had significant effect on immediate outcome, with self-disclosure, interpretation, approval, and paraphrase being the most helpful response modes. Found large individual differences in…

  17. Looking into a Deaf Child's Future: A Brief Treatment Approach.

    Science.gov (United States)

    Harvey, Michael A.; Green, Christine L.

    1990-01-01

    A hearing mother who reported obsessional thoughts about her deaf child's future underwent brief psychotherapy. Clinical hypnosis modified the mother's negative images of her child's future, and meetings attended by the mother, a vocational counselor, and deaf adults affirmed the more positive images. Theoretical descriptions and personal…

  18. Leadership: Improving Its Effectiveness. Research Action Brief Number 1.

    Science.gov (United States)

    ERIC Clearinghouse on Educational Management, Eugene, OR.

    This brief summarizes the major findings of significant research studies dealing with different leadership behaviors and strategies for increasing leadership effectiveness. Fred Fiedler's Contingency Theory of Leadership Effectiveness emphasizes that a leader's effectiveness is determined by how well his leadership style fits the specific…

  19. Keeping Young People in (Vocational) Education: What Works? Briefing Note

    Science.gov (United States)

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    Too many young people leave education (including vocational education) too soon. Yet early leavers are at greater risk of long-term unemployment, poverty and crime, and now cost the European economy 1.25% of GDP. This brief report looks at the reasons why young people leave and what could be done to end this trend. Considerations for policy-makers…

  20. Information Brief on Green Power Marketing, 2nd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Sweezey, B.; Houston, A.

    1998-02-01

    This document is the second in a series of information briefs on green power marketing activity in the United States. It includes descriptions of utility green pricing programs, green power marketing activity, retail access legislation and pilot programs, and other data and information supporting the development of green power markets.

  1. A brief review of feed-forward neural networks

    OpenAIRE

    SAZLI, Murat Hüsnü

    2006-01-01

    Artificial neural networks, or shortly neural networks, find applications in a very wide spectrum. In this paper, following a brief presentation of the basic aspects of feed-forward neural networks, their mostly used learning/training algorithm, the so-called back-propagation algorithm, have been described.

  2. Brief-Term Psychological Adjustment of Sexually Abused Children.

    Science.gov (United States)

    Wagner, William G.

    1991-01-01

    In this study of brief-term concomitant of child sexual abuse, children's reports of self-concept and depression, and parents' ratings of their children's depressive symptomology, were examined for child victims of molestation or sexual abuse outside the family, and for nonabused children whose parents sought psychological services for them. (BB)

  3. Musical "Tune-Ups" for Couples: Brief Treatment Interventions

    Science.gov (United States)

    Duba, Jill D.; Roseman, Christopher

    2012-01-01

    Some couples seek counseling to address warning signs. They may not be facing a relationship crisis but may be more concerned about where they are headed. Hence, a marriage makeover may not necessarily be needed, but instead couples in counseling may benefit from something rejuvenating. In such cases, brief interventions or techniques may be…

  4. Organizational Culture and Internationalization: A Brief Literature Review

    Science.gov (United States)

    Nussbaumer, Alison

    2013-01-01

    This brief literature review introduces an area of emerging research about the impact of organizational culture on institutional strategies for internationalization. The review begins by introducing the concept of organizational culture, particularly within higher education. Five articles published between 2003 and 2012 are examined that introduce…

  5. A Brief Method for Conducting a Negative-Reinforcement Assessment.

    Science.gov (United States)

    Zarcone, Jennifer R.; Crosland, Kimberly; Fisher, Wayne W.; Worsdell, April S.; Herman, Kelly

    1999-01-01

    A brief negative-reinforcement assessment was conducted with five children (ages 4 to 14) with developmental disabilities with severe destructive behavior. Children were trained to engage in an escape response and were presented with a variety of stimuli. For each child, several stimuli were identified that may serve as effective negative…

  6. Towards the european strategy for particle physics : The briefing book

    NARCIS (Netherlands)

    Akesson, T.; Aleksan, R.; Allanach, B.; Bertolucci, S.; Blondel, A.; Butterworth, J.; Cavalli-Sforza, M.; Cervera, A.; de Naurois, M.; Desch, K.; Egede, U.; Heuer, R.; Hoecker, A.; Huber, P.; Jungmann, K.; Linde, F.; Lombardi, A.; Mangano, M.; Mezzetto, M.; Onderwater, G.; Palanque-Delabrouille, N.; Peach, K.; Polosa, A.; Rondio, E.; Webber, B.; Weiglein, G.; Womersley, J.

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates mat

  7. Readiness for Change. Scaling-Up Brief. Number 3

    Science.gov (United States)

    Fixsen, Dean L.; Blase, Karen A.; Horner, Rob; Sugai, George

    2009-01-01

    The purpose of this "Brief" is to define the variables a state or large district leadership team may wish to consider as they determine if they are "ready" to invest in the scaling-up of an innovation in education. As defined here, "scaling up" means that at least 60% of the students who could benefit from an innovation have access to that…

  8. Regenerative medicine. Opportunities and challenges: a brief overview

    OpenAIRE

    Polak, Dame Julia

    2010-01-01

    Regenerative medicine is a new multi-disciplinary field aiming at the repair or replacement of disease body parts. The field is progressing at an unprecedented pace and although the opportunities are immense, many hurdles lie ahead. This brief review analyses the opportunities and challenges faced by regenerative medicine.

  9. 78 FR 9431 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2013-02-08

    ... BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board. ACTION: Notice. SUMMARY: The Merit Systems Protection Board (MSPB or Board) announces the opportunity to file amicus... Enhancement Act of 2012 (WPEA), 112 Public Law 199, may be applied retroactively to pending cases...

  10. 78 FR 17233 - Notice of Opportunity To File Amicus Briefs

    Science.gov (United States)

    2013-03-20

    ... BOARD Notice of Opportunity To File Amicus Briefs AGENCY: Merit Systems Protection Board. ACTION: Notice. SUMMARY: The Merit Systems Protection Board (MSPB or Board) announces the opportunity to file amicus... Enhancement Act of 2012 (WPEA), 112 Public Law 199, with regard to damages may be applied retroactively...

  11. The Secret to Finland's Success: Educating Teachers. Research Brief

    Science.gov (United States)

    Sahlberg, Pasi

    2010-01-01

    In the last decade, Finland has emerged as the leading OECD country in educational achievement. In examining the sources of Finland's dramatic rise to the top, research shows one key element that has impacted Finland's success above all others: excellent teachers. This policy brief details the key elements of Finland's successful system, examining…

  12. A brief assessment of physical functioning for prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Jin-Shei Lai

    2010-06-01

    Full Text Available Jin-Shei Lai1, Rita Bode2, Hwee-Lin Wee3, David Eton4, David Cella11Department of Medical Social Sciences, 2Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, IL USA; 3Department of Pharmacy, National University of Singapore, Singapore; 4Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USAAbstract: We aimed to validate a more rapid, yet reliable means of assessing physical function (PF for patients with prostate cancer. The sample included 128 prostate cancer patients recruited from urology and general oncology clinics at two Chicago-area hospitals. The main outcome measures were: A 36-item PF item bank that included a 5-item short form (BriefPF and the 10-item PF subscale (PF-10 from the Medical Outcomes Study SF-36. Validity, information function, and relative precision (calculated using Rasch analysis and raw scores of the BriefPF were compared to the PF-10 and the full PF item bank. We found that the BriefPF and PF-10 were strongly correlated (r = 0.85 with the PF bank, and all three scales differentiated patients according to performance status (FPF bank(2,124 = 32.51 P < 0.001, FPF-10(2,121 = 27.35 P < 0.001, FBriefPF (2,123 = 38.40 P < 0.001. BriefPF has excellent precision relative to the PF-10 in measuring patients with different performance status levels. The Rasch-based information function indicated that the BriefPF was more informative than PF-10 in measuring moderate to higher functioning patients. Hence, the BriefPF offers a parsimonious and precise measure of PF for use among men with prostate cancer, and may aid in the timely inclusion of patient-reported outcomes in treatment decision-making.Keywords: quality-of-life, item bank, short-form, Medical Outcomes Study

  13. A brief history of the philosophy of time

    CERN Document Server

    Bardon, Adrian

    2013-01-01

    Adrian Bardon's A Brief History of the Philosophy of Time is a short introduction to the history, philosophy, and science of the study of time-from the pre-Socratic philosophers through Einstein and beyond. A Brief History of the Philosophy of Time covers subjects such as time and change, the experience of time, physical and metaphysical approaches to the nature of time, the direction of time, time travel, time and freedom of the will, and scientific and philosophical approaches to eternity and the beginning of time. Bardon employs helpful illustrations and keeps technical language to a minimum in bringing the resources of over 2500 years of philosophy and science to bear on some of humanity's most fundamental and enduring questions.

  14. Prediction of outcome of brief psychotherapy from therapist interpretive interventions.

    Science.gov (United States)

    Marziali, E A

    1984-03-01

    This study replicated Malan's 1976 analysis of psychodynamic interpretations and corrected the major methodological fault in his work: the use of therapist notes for rating the interpretive elements. In this study, the sessions of 25 patients treated in brief dynamic psychotherapy were audiotaped and the ratings of the interpretive interventions were made directly from the audiotapes. Malan's findings were supported. There was a positive association between more favorable outcome, measured on five psychodynamic scales, and the frequency with which therapist interpretations referred to emotions experienced in the transference relationship that were similar to those experienced in relationships with parents and other important persons. The results of this replication indicate that these therapist-offered explanations about the meanings of significant current and past interpersonal relationships contribute to the outcome of brief psychotherapy.

  15. Substance Use Screening, Brief Intervention, and Referral to Treatment.

    Science.gov (United States)

    2016-07-01

    The enormous public health impact of adolescent substance use and its preventable morbidity and mortality show the need for the health care sector, including pediatricians and the medical home, to increase its capacity related to substance use prevention, detection, assessment, and intervention. The American Academy of Pediatrics published its policy statement "Substance Use Screening, Brief Intervention, and Referral to Treatment for Pediatricians" in 2011 to introduce the concepts and terminology of screening, brief intervention, and referral to treatment (SBIRT) and to offer clinical guidance about available substance use screening tools and intervention procedures. This policy statement is a revision of the 2011 SBIRT statement. An accompanying clinical report updates clinical guidance for adolescent SBIRT. PMID:27325638

  16. Brief overview of BioMicroNano Technologies.

    Energy Technology Data Exchange (ETDEWEB)

    Gourley, Paul Lee

    2005-01-01

    This paper provides a brief overview of the fields of biological micro-electromechanical systems (bioMEMs) and associated nanobiotechnologies, collectively denoted as BioMicroNano. Although they are developing at a very rapid pace and still redefining themselves, several stabilized areas of research and development can be identified. Six major areas are delineated, and specific examples are discussed and illustrated. Various applications of the technologies are noted, and potential market sizes are compared.

  17. An unusual presentation of brief recurrent psychosis: a case report

    OpenAIRE

    Krishnamurthy CN; Sanivarapu, Sravanti L.

    2012-01-01

    Background: Although the term "zycloiden psychosen" was first used by Karl Kleist in 1926 to group together disorders, which had presented with sudden onset, brief episodic course, polymorphous psychotic symptoms and good inter-episode recovery, its origin can be traced back to 1880s. Despite its existence in the community, for so long, the diagnosis of cycloid psychosis is only seldom made, making it a unique disorder. Hence, there seems to be lack of awareness of this rare entity even among...

  18. Backward stochastic Volterra integral equations- a brief survey

    Institute of Scientific and Technical Information of China (English)

    YONG Jiong-min

    2013-01-01

    In this paper, we present a brief survey on the updated theory of backward stochas-tic Volterra integral equations (BSVIEs, for short). BSVIEs are a natural generalization of backward stochastic diff erential equations (BSDEs, for short). Some interesting motivations of studying BSVIEs are recalled. With proper solution concepts, it is possible to establish the corresponding well-posedness for BSVIEs. We also survey various comparison theorems for solutions to BSVIEs.

  19. Does cognitive perception have access to brief temporal events?

    OpenAIRE

    Hess, Robert F.; Maehara, Goro

    2011-01-01

    To determine whether conscious perception has access to brief temporal event, we asked subjects in an odd-man out paradigm to determine which of the four Gaussian blobs was flickering asynchronously in time. We measure synchrony thresholds as a function of the base temporal frequency for spatially scaled stimuli in foveal and peripheral vision. The results are consistent with a time delay of around 67 milliseconds (ms) for foveal vision and 91 ms for peripheral vision. We conclude that consci...

  20. Brief report on Open Praxis dissemination, abstracting and impact

    Directory of Open Access Journals (Sweden)

    Inés Gil-Jaurena

    2014-07-01

    Full Text Available The editorial project for the relaunching of Open Praxis as the ICDE scholarly, peer-reviewed and open access journal included three main aspects: editorial process, scientific quality and dissemination. After 6 published issues in 2013 and 2014, this editorial focuses on the last aspect, related to visibility, providing a brief report on the actions developed to promote Open Praxis. A second part introduces the nine papers included in the issue.

  1. D2.4. Briefing paper for first workshop

    OpenAIRE

    Watson, Hayley; Wadhwa, Kush; van Os, Nico; Dekkers, Chris; Baruh, Lemi; Papadimitriou, Alex

    2015-01-01

    EXECUTIVE SUMMARY This briefing paper provides an overview of the key findings from the completion of three reports relating to the use of new media in crisis situations that have been completed as part of the COSMIC project. COSMIC, “Contribution of Social Media in Crisis management”, is a two-year project that is funded under the European Commission's Seventh Framework Programme FP7-SEC-2012 under grant agreement no. 312737. The first report, D2.1, identified existin...

  2. FISHING IN SINALOA: BRIEF HISTORY AND SEARCH OF EPISTEME

    OpenAIRE

    Ramón Enrique Morán-Angulo; Luis Miguel Flores-Campaña

    2015-01-01

    This paper reports from bibliographic woven into three sections: a brief history of the prehispanic fishing, where the encounter between the indigenous communities of the State of Sinaloa and species that supported the incursion of primitive society in the various ecosystems are described water that make up the vast and varied territory of Sinaloa, where fishing is born as a function of interaction between society and nature through a deep empirical knowledge and a handmade primitive instrume...

  3. Guessing personality from a brief sample of behaviour

    OpenAIRE

    Wu, Wenjie

    2015-01-01

    Mentalising as a process for explaining and predicting behavior relates to inferring mental states and traits of others. Previous research of mentalising has focused too heavily on mental states and insufficiently on personality traits. Given this context, the current thesis aimed to explore the phenomenon of forming first impressions of personality based on a brief sample of behavior. In the current research, after being filmed in diverse naturalistic scenarios, targets filled in an “emp...

  4. A Brief Analysis on Empty Categories in Chinese

    Institute of Scientific and Technical Information of China (English)

    XIONG Shao-li

    2014-01-01

    This paper aims to give a brief analysis on the Empty Categories in Chinese. It will first illustrate Chomsky ’s classifica-tion of EC as well as the constraints the subject to briefly, then basing on this classification the author will state some of Chinese scholars’study and research including Xu Liejiong , Huang Zhengde and Hu Jianjun. Finally, the author will compare these clas-sic frameworks and attempt to.

  5. A brief psychological intervention that reduces adolescent alcohol consumption.

    OpenAIRE

    Armitage, Christopher J.; Rowe, Richard; Arden, Madelynne; Harris, Peter R.

    2014-01-01

    Objective: Alcohol consumption in adolescence is associated with problem drinking in later life, and there is a need to develop evidence-based interventions to reduce adolescent alcohol consumption. The aims of the present study were to test the ability of a very brief intervention based on self-affirmation theory to reduce alcohol consumption in a sample of adolescents and to examine potential mediators of the effects. Method: 67 adolescents were randomly allocated either to form a self-affi...

  6. A brief overview of the Civil Union Act

    OpenAIRE

    N Ntlama

    2010-01-01

    The adoption of the Constitution of the Republic of South Africa, 1996 (the Constitution) has provided a sound framework for the elimination of discrimination and prejudice against all members of our society. The Constitution provides for equal recognition of the right to freedom of religion and sexual orientation within the framework of the right to equality. This note aims to provide a brief overview and analysis of the general and potentially problematic features of the C...

  7. A brief history of vaccines & vaccination in India

    OpenAIRE

    Chandrakant Lahariya

    2014-01-01

    The challenges faced in delivering lifesaving vaccines to the targeted beneficiaries need to be addressed from the existing knowledge and learning from the past. This review documents the history of vaccines and vaccination in India with an objective to derive lessons for policy direction to expand the benefits of vaccination in the country. A brief historical perspective on smallpox disease and preventive efforts since antiquity is followed by an overview of 19 th century efforts to replace ...

  8. Briefing book on environmental and waste management activities

    International Nuclear Information System (INIS)

    The purpose of the Briefing Book is to provide current information on Environmental Restoration and Waste Management Activities at the Hanford Site. Each edition updates the information in the previous edition by deleting those sections determined not to be of current interest and adding new topics to keep up to date with the changing requirements and issues. This edition covers the period from October 15, 1992 through April 15, 1993

  9. A Brief Introduction of Communicative Translation Teaching Method

    Institute of Scientific and Technical Information of China (English)

    梁宇; 方艾若

    2013-01-01

      The purpose of this paper is to introduce a new translation teaching method which is based on Skopos theory and commu⁃nicative translation competence training. It makes a brief analysis of the functionalist framework for translation teaching. When more and more universities of China open translation courses for under graduates and postgraduates, it is hoped that this paper could slightly contribute to the translation teaching field.

  10. A brief social history of astrobiology in Ibero-america

    CERN Document Server

    Lemarchand, Guillermo A

    2010-01-01

    The work is divided into three sections: the first one describes the historical evolution of the main arguments presented about the plurality of inhabited worlds, from the presocratics to the birth of modern science. The second section analyzes the race to define the search for life beyond Earth as a scientific activity under a specific name. Finally, the third part presents a brief description of the social history of science that allowed the early development of astrobiology in Iberoamerica.

  11. A New Brief Measure of Oral Quality of Life

    Directory of Open Access Journals (Sweden)

    Nancy R. Kressin, PhD

    2008-04-01

    Full Text Available IntroductionWe developed a brief measure of the impact of oral conditions on individual functioning and well-being, known as oral quality of life.MethodsAmong older male veterans (N = 827 and community dental patients (N = 113, we administered surveys consisting of extant oral quality of life items, using clinical dental data from the veteran samples. We assigned each oral quality of life item to a theoretical dimension, conducted an iterative series of multitrait scaling analyses to examine the item-fit with the dimensions, reduced the number of items, and examined the psychometric characteristics of new scales and their association with clinical indices.ResultsWe developed two brief oral quality of life scales, one consisting of 12 items and the other of 6, the latter a subset of the former. Each demonstrated sound psychometric properties and was sensitive to clinical indices.ConclusionThe two brief oral quality of life scales can be used to assess the population-based impact of oral conditions as well as outcomes of dental care.

  12. Illness perception in Polish patients with chronic diseases: Psychometric properties of the Brief Illness Perception Questionnaire.

    Science.gov (United States)

    Nowicka-Sauer, Katarzyna; Banaszkiewicz, Dorota; Staśkiewicz, Izabela; Kopczyński, Piotr; Hajduk, Adam; Czuszyńska, Zenobia; Ejdys, Mariola; Szostakiewicz, Małgorzata; Sablińska, Agnieszka; Kałużna, Anna; Tomaszewska, Magda; Siebert, Janusz

    2016-08-01

    The study evaluates the psychometric properties of a Polish translation of the Brief Illness Perception Questionnaire. A total of 276 patients with chronic conditions (58.7% women) completed the Brief Illness Perception Questionnaire and the Hospital Anxiety and Depression Scale. The internal consistency of the Polish Brief Illness Perception Questionnaire measured with Cronbach's alpha was satisfactory (α = 0.74). Structural validity was demonstrated by significant inter-correlations between the Brief Illness Perception Questionnaire components. Discriminant validity was supported by the fact that the Brief Illness Perception Questionnaire enables patients with various conditions to be differentiated. Significant correlations were found between Brief Illness Perception Questionnaire and depression and anxiety levels. The Polish Brief Illness Perception Questionnaire thus evaluated is a reliable and valid tool.

  13. Test Review: Review of Kaufman Brief Intelligence Test, Second Edition: Kaufman, A. S., & Kaufman, N. L. (2004). "Kaufman Brief Intelligence Test, Second Edition". Bloomington, MN: Pearson, Inc.

    Science.gov (United States)

    Bain, Sherry K.; Jaspers, Kathryn E.

    2010-01-01

    This article presents a review of the Kaufman Brief Intelligence Test, Second Edition (KBIT-2; Kaufman & Kaufman, 2004b), which is designed to provide a brief, individualized format for measuring verbal and nonverbal intelligence in children and adults from the ages of 4 years, 0 months through 90 years, 11 months. The test consists of only three…

  14. Screening and brief intervention for alcohol and other abuse.

    Science.gov (United States)

    Harris, Sion Kim; Louis-Jacques, Jennifer; Knight, John R

    2014-04-01

    Substance use is the most common health risk behavior among adolescents and is one of the greatest threats to their current and future health. Universal screening of adolescents in general medical settings can be instrumental in identifying substance use early, before further problems develop and when BIs are more likely to be effective. Screening in and of itself may have some therapeutic effect. Brief screening tools feasible for use by busy medical offices to quickly and reliably assess adolescent risk for a substance use disorder now are available. A recent study found that a physician-conducted CRAFFT screen interview required an average of 74 seconds to complete, whereas a computer self-administered version took an average of 49 seconds. The CRAFFT and AUDIT tools currently have the most evidence for validity among adolescents, whereas the validity of other widely used tools such as DAST-10, NIDA-modified ASSIST (Alcohol, Smoking and Substance Involvement Screening Test), and ultra-brief screens (AUDIT-C, single-item screens) has yet to be established for adolescents. Studies are needed to identify effective strategies to promote universal adolescent screening and the use of valid screening tools in general medical settings. One statewide (Massachusetts) study found that although most (86%) primary care physicians seeing adolescents reported screening adolescents for substance use annually, only 1 in 3 reported using a validated tool (the CRAFFT). The remaining physicians reporting using informal screening procedures, their own questionnaire, or the CAGE. Computerization of screening and integration into the electronic health record appear to be promising strategies to promote universal screening and standardized use of valid screening tools. Increasing adolescent screening rates necessitates supporting physicians' ability to respond effectively to the screen results. To that end, recent evidence-informed practice guides from the AAP and NIAAA provide a

  15. Xeroderma Pigmentosum: A Bane in developing country – Brief report

    Directory of Open Access Journals (Sweden)

    Hari Kishan Kumar Yadalla

    2014-10-01

    Full Text Available Xeroderma pigmentosum (XP is a rare autosomal recessive disorder characterized by photosensitivity, cutaneous pigmentary changes, premature skin ageing, and the development of various cutaneous and internal malignancies at an early age. We present this case of a 10 year-old girl in a developing country like India, with significant corneal scarring and multiple cutaneous skin lesions in sun-exposed areas. Developmental delay had been present since 3 months of age, with these clinical features it was consistent with Xeroderma Pigmentosum. We highlight the difficulties encountered due to the lack of diagnostic and treatment modalities for this child, and offer a brief review of XP, including emerging treatments.

  16. A brief account of Julius Planer's life and research

    Directory of Open Access Journals (Sweden)

    R. Bilyy

    2010-01-01

    Full Text Available A brief account of the life and research activities of Julius Planer is presented. Professor Planer is a scientist who lived one and half century ago. However, his studies, in particular, during the years when he headed Department of Anatomy at Universität in Lemberg, nowadays known as the Ivan Franko National University of Lviv in Ukraine, were essential to a modern understanding of liquid crystals. While working at Lviv University, Planer also made several landmark contributions to biomedical science.

  17. Brief-stimulus presentations on multiform tandem schedules

    OpenAIRE

    Reed, Phil

    1994-01-01

    Three experiments examined the influence of a brief stimulus (a light) on the behavior of food-deprived rats whose lever pressing on tandem schedules comprising components of different schedule types resulted in food presentation. In Experiment 1, either a tandem variable-ratio variable-interval or a tandem variable-interval variable-ratio schedule was used. The variable-interval requirement in the tandem variable-ratio variable-interval schedule was yoked to the time taken to complete the va...

  18. Digital Library Activities in Europe: A Brief Overview

    Directory of Open Access Journals (Sweden)

    Jia Liu

    2005-06-01

    Full Text Available The article is a brief overview of the digital library activities happening in the last decade in Europe. At first the definitions of the digital library was discussed. Then in the main part of the article the programs and projects on the digital library taking place in Europe are described briefly at three levels, which are digital library activities across Europe, national digital library activities and local digital library activities. In addition to the programs and projects several examples of the conferences and institutions in the field are also given in the article. Finally some conclusions are drawn based on the description above.

  19. Brief to the Cluff Lake Board of Inquiry

    International Nuclear Information System (INIS)

    The purpose of this brief is to describe the structure and operations of the Atomic Energy Control Board, and to indicate how these relate to current activities and to possible future developments with respect to the nuclear fuel cycle. The problem areas from the regulatory viewpoint may be identified as follows: protection of the health of workers and the public; protection of the environment; the safe use of nuclear materials, equipment and technology for peaceful and lawful purposes. The attention of regulatory authorities has been focused on all these areas, perhaps without much public awareness, but today the increasing public concern necessitates a parallel increase in public information and participation

  20. Operations research at CSIR: A brief history through cases

    Directory of Open Access Journals (Sweden)

    HW Ittmann

    2007-06-01

    Full Text Available Apart from work in the mining industry during the 1950s, the first real Operations Research (OR group in South Africa was established at CSIR in the early 1960s. Those initially involved in this group played a significant role in establishing OR at various universities in South Africa. The OR group at CSIR did, however, continue and today the group still exists. This paper presents a brief history of this group and endeavours to provide a glimpse of some of the projects conducted over the many years since its establishment.

  1. Examination of a brief Smoking Consequences Questionnaire for college students.

    Science.gov (United States)

    Schleicher, Holly E; Harris, Kari Jo; Catley, Delwyn; Harrar, Solomon W; Golbeck, Amanda L

    2008-09-01

    This study examined the factor structure of a brief version of the Smoking Consequences Questionnaire-Adult (SCQ-A) among 315 college freshman and sophomore smokers. A comparison of results from two confirmatory factor analyses demonstrated that a nine-factor model provided superior fit to a four-factor model. Furthermore, results revealed a lack of factorial invariance of factor loadings for daily and nondaily smokers, and of latent mean structures for smoking category and gender. In addition, concurrent validity tests demonstrated that positive expectancies increased with smoking rate and nicotine dependence. These results and their implications are discussed.

  2. ROMANIAN AERONAUTICAL METEOROLOGY APPLICABLE LEGAL FRAMEWORK –BRIEFING

    Directory of Open Access Journals (Sweden)

    CATALIN POPA

    2012-05-01

    Full Text Available The purpose of this briefing is toprovide an overview of the aeronautical meteorology legal framework in Romania. In this context, the role and importance of aeronautical meteorology in international air traffic management will be underlined, with focus on the civil aviation activity in Romania. The international legal framework and modalities of implementing these rules at national level will constitute a significant part of the present study., Specific accent will be put on the national regulatory framework and structure, means of updating it, and how it responds to changing regulatory requirements.

  3. Towards the European strategy for particle physics the Briefing Book

    CERN Document Server

    Åkesson, T; Allanach, Benjamin C; Bertolucci, S; Blondel, A; Butterworth, J; Cavalli-Sforza, M; Cervera-Villanueva, Anselmo; Davidson, S; De Naurois, Mathieu; Desch, K; Egede, U; Glover, N; Heuer, R D; Huber, P; Höcker, A; Jungmann, K; Landua, Rolf; Le Goff, J M; Linde, Frank L; Lombardi, A; Mangano, Michelangelo L; Mezzetto, M; Onderwater, G; Palanque-Delabrouille, Nathalie; Peach, Kenneth J; Polosa, A; Rondio, E; Webber, Bryan R; Weiglein, G; Womersley, J; Wurr, K

    2007-01-01

    This document was prepared as part of the briefing material for the Workshop of the CERN Council Strategy Group, held in DESY Zeuthen from 2nd to 6th May 2006. It gives an overview of the physics issues and of the technological challenges that will shape the future of the field, and incorporates material presented and discussed during the Symposium on the European Strategy for Particle Physics, held in Orsay from 30th January to 2nd February 2006, reflecting the various opinions of the European community as recorded in written submissions to the Strategy Group and in the discussions at the Symposium.

  4. A Brief Account on the Functions of Rhetorical Repetition

    Institute of Scientific and Technical Information of China (English)

    Li Yuping

    2000-01-01

    It is believed that using rhetoric devices precisely is of great importance for the English Learners, if they want to write good articles. Repetition is one of the rhetoric devices that is frequently used in English writing. This paper gives a brief account on the four functions of repetition by presenting some typical examples, focusing the reader's attention on the significance of this device in the English writing. The following are the four functions: an effective means of emphasis; making anidea clear and easier; generating emotional force; heightening a certain atmosphere.

  5. Time course of conflict processing modulated by brief meditation training

    Directory of Open Access Journals (Sweden)

    Yaxin eFan

    2015-07-01

    Full Text Available Resolving conflict is a pivotal self-control ability for human adaptation and survival. Although some studies reported meditation may affect conflict resolution, the neural mechanisms are poorly understood. We conducted a fully randomized 5 hours trial of one form of mindfulness meditation - Integrative Body-Mind Training (IBMT in comparison to a relaxation training control. During the Stroop word-color task, IBMT group produced faster resolution of conflict, a smaller N2 and an earlier and larger P3 component of the event-related brain potentials (ERPs. These results indicate that brief meditation training induces a brain state that improves the resolution of conflict.

  6. A Brief Introduction to Astronomy in the Middle East

    CERN Document Server

    Steele, John M

    2012-01-01

    The Middle East is the birthplace of astronomy and the centre for its development during the medieval period. In this brief introduction John Steele offers an intriguing insight into Middle Eastern achievements in astronomy and their profound influence on the rest of the world. Amongst other things, the book traces the Late Babylonians' ingenious schemes for modelling planetary motion. It also reveals how medieval Islamic advances in the study of the heavens, and the design of precise astronomical instruments, led to breakthroughs by Renaissance practitioners such as Copernicus and Kepler. An

  7. An unusual presentation of brief recurrent psychosis: a case report

    Directory of Open Access Journals (Sweden)

    Krishnamurthy CN

    2012-12-01

    Full Text Available Background: Although the term "zycloiden psychosen" was first used by Karl Kleist in 1926 to group together disorders, which had presented with sudden onset, brief episodic course, polymorphous psychotic symptoms and good inter-episode recovery, its origin can be traced back to 1880s. Despite its existence in the community, for so long, the diagnosis of cycloid psychosis is only seldom made, making it a unique disorder. Hence, there seems to be lack of awareness of this rare entity even among the psychiatrists.Case description: A middle-aged woman with abrupt onset of recurrent brief episodes of psychotic symptoms, and complete inter-episode recovery, was admitted with history of alleged consumption of poison in a state of confusion. During psychotic episodes, motility disturbances were predominant. The current episode lasted for about two weeks.Discussion: This case doesn't satisfy the criteria for schizophrenia or affective illness. Although ICD-10 describes 'acute polymorphic psychotic disorder' (F23.0, F23.1 it requires the presence of typical schizophrenic symptoms for its diagnosis and is usually not recurrent. The closest this case resembles is cycloid psychosis, meeting three of four Perris criteria.Conclusion: The diagnosis of such unusual cases of psychosis predicts the prognosis and helps in assessment and management of future episodes.

  8. A brief intervention for fatigue management in breast cancer survivors.

    Science.gov (United States)

    Fillion, Lise; Gagnon, Pierre; Leblond, Francine; Gélinas, Céline; Savard, Josée; Dupuis, Réjeanne; Duval, Karine; Larochelle, Marie

    2008-01-01

    The purpose of this randomized control trial was to verify the effectiveness of a brief group intervention that combines stress management psycho-education and physical activity (ie, independent variable) intervention in reducing fatigue and improving energy level, quality of life (mental and physical), fitness (VO 2submax), and emotional distress (ie, dependent variables) in breast cancer survivors. This study applied Lazarus and Folkman stress-coping theoretical framework, as well as Salmon's unifying theory of physical activity. Eighty-seven French-speaking women who had completed their treatments for nonmetastatic breast cancer at a university hospital in Quebec City, Canada, were randomly assigned to either the group intervention (experimental) or the usual-care (control) condition. Data were collected at baseline, postintervention, and at 3-month follow-up. The 4-week group intervention was cofacilitated by 2 nurses. Results showed that participants in the intervention group showed greater improvement in fatigue, energy level, and emotional distress at 3-month follow-up, and physical quality of life at postintervention, compared with the participants in the control group. These results suggest that a brief psycho-educational group intervention focusing on active coping strategies and physical activity is beneficial to cancer survivors after breast cancer treatments.

  9. My brief history. 2. ed.; Meine kurze Geschichte

    Energy Technology Data Exchange (ETDEWEB)

    Hawking, Stephen

    2015-11-01

    For the first time, Stephen Hawking turns his gaze inward for a revealing look at his own life and intellectual evolution. My Brief History recounts Stephen Hawking's improbable journey, from his post-war London boyhood to his years of international acclaim and celebrity. Illustrated with rarely seen photographs, this concise, witty and candid account introduces readers to the inquisitive schoolboy whose classmates nicknamed him 'Einstein'; the jokester who once placed a bet with a colleague over the existence of a black hole; and the young husband and father striving to gain a foothold in the world of academia. Writing with humility and humour, Hawking opens up about the challenges that confronted him following his diagnosis of ALS aged twenty-one. Tracing his development as a thinker, he explains how the prospect of an early death urged him onward through numerous intellectual breakthroughs, and talks about the genesis of his masterpiece A Brief History of Time - one of the iconic books of the twentieth century.

  10. Brief updates on ongoing topics: Iter, IYNC, waste management legislation

    International Nuclear Information System (INIS)

    The status of the competition to determine the future site for Iter is outlined. This includes a review of developments at recent negotiations meetings in Moscow, statements from the G8 Energy Ministers' Conference in Detroit and the latest from the fourth negotiations meetings held in France. The Young Generation Network has sponsored two conferences: the first called the International Youth in Nuclear Congress held in Bratislava, Slovakia, in 2000, and the second held in Seoul, Korea in April 2002. The Canadian arm of the YGN submitted a proposal to hold the 3rd IYNC in Toronto in 2004, and the proposal was accepted at the meeting in Seoul. Plans for developing this event will be outlined. The Nuclear Fuel Waste Act (Bill C-27) has been passed by the House of Commons, and is under review by the Senate Committee on Energy, the Environment and Natural Resources. A brief outline of the background leading up to the development of this legislation, and a brief description of the legislation, is provided

  11. Briefing Products - Tools for Communicating Technical Issues to a Non-Technical Audience

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Harvey Clark, Kevin T. Foster

    2011-06-09

    Briefing Products are a new NARAC/IMAAC product line designed to communicate the consequences of a radiological, nuclear, chemical or biological agent incident to non-technical decision makers and key leaders. Each Briefing Product addresses a single decision or issue focused on potential actions that should be considered when responding to a hazard, while avoiding the use of technical or regulatory jargon. Briefing Products do not make protective action recommendations, although they do concretely assist decision-makers with development of their own protective actions by quoting or paraphrasing the published guidance relevant to the decision at hand. Briefing Products are produced in sets tailored to specific types of incident which together depict the key decisions and characteristics of the incident. Each Briefing Product in the set consists of three elements: (1) Primary Effects, (2) Key Points and (3) Presenter Notes. Both the Primary Effects and Key Points are ready for direct presentation, while the Presenter Notes are designed to provide background information to the presenter and are not for direct presentation to the audience. The Briefing Products themselves are alternative presentations of results from the customary standard NARAC/IMAAC technical products. Currently, Briefing Products are available for detonation of both RDDs (Radiological Dispersal Devices) and INDs (Improvised Nuclear Devices). A new set of products tailored to nuclear power plant (NPP) accidents is currently under development. This paper describes the scope, structure and content of the Briefing Product sets. Examples from the two sets of Briefing Products now available are presented.

  12. Quarterly Briefing Book on Environmental and Waste Management Activities

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.C.

    1991-06-01

    The purpose of the Quarterly Briefing Book on Environmental and Waste Management Activities is to provide managers and senior staff at the US Department of Energy-Richland Operations Office and its contractors with timely and concise information on Hanford Site environmental and waste management activities. Each edition updates the information on the topics in the previous edition, deletes those determined not to be of current interest, and adds new topics to keep up to date with changing environmental and waste management requirements and issues. Section A covers current waste management and environmental restoration issues. In Section B are writeups on national or site-wide environmental and waste management topics. Section C has writeups on program- and waste-specific environmental and waste management topics. Section D provides information on waste sites and inventories on the site. 15 figs., 4 tabs.

  13. Biofield therapies in cardiovascular disease management: a brief review.

    Science.gov (United States)

    Anderson, Joel G; Taylor, Ann Gill

    2011-01-01

    Though there have been advances over the last 30 years in the therapeutic approaches to cardiovascular disease (CVD), heart disease and stroke remain the leading cause of mortality and morbidity worldwide. Many medical therapies for CVD are associated with a number of side effects, often leading patients to seek non-pharmacological treatments to complement standard care. Referred to as complementary and alternative medicine (CAM), these therapies consist of a heterogeneous group of modalities used in addition to conventional health care. Biofield therapies exist within this CAM domain and involve the direction of healing energy to facilitate general health and well-being by modifying the energy field. What follows is a brief overview of three biofield therapies developed or used within the field of nursing (Therapeutic Touch, Reiki, and Healing Touch), surveying the use of these interventions for individuals with CVD, and outcomes that may impact CVD risk factors and health-related quality of life.

  14. Quarterly Briefing Book on Environmental and Waste Management Activities

    International Nuclear Information System (INIS)

    The purpose of the Quarterly Briefing Book on Environmental and Waste Management Activities is to provide managers and senior staff at the US Department of Energy-Richland Operations Office and its contractors with timely and concise information on Hanford Site environmental and waste management activities. Each edition updates the information on the topics in the previous edition, deletes those determined not to be of current interest, and adds new topics to keep up to date with changing environmental and waste management requirements and issues. Section A covers current waste management and environmental restoration issues. In Section B are writeups on national or site-wide environmental and waste management topics. Section C has writeups on program- and waste-specific environmental and waste management topics. Section D provides information on waste sites and inventories on the site. 15 figs., 4 tabs

  15. A brief description of Polanco`s hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Ventura [Instituto de Ingenieria Electrica, Universidad de la Republica, Montevideo (Uruguay)

    1997-12-31

    Since 1995, a hybrid system wind - PV is in service in Polanco, Uruguay. A brief description of this system and the criteria employed in its design are outlined. The experience obtained during two years operation are described from the points of view of the equipment reliability and of the electrical service provided. Future prospects of this kind of installations in Uruguay as part of the rural electrification policy are presented. [Espanol] Desde 1995 esta en servicio en Polanco, Uruguay un sistema hibrido viento-fotovoltaico. Aqui se describe brevemente este sistema y el criterio empleado en su diseno. Se describe la experiencia obtenida durante dos anos de operacion desde el punto de vista de confiabilidad de los equipos y del servicio electrico proporcionado. Se presentan prospectos futuros de esta clase de instalaciones en Uruguay, como parte de la politica de electrificacion rural.

  16. A Brief Analysis to the 3-Step Translation Process

    Institute of Scientific and Technical Information of China (English)

    丘胜祥

    2009-01-01

    With the development of science and technology,the culture of translation still is multiplied continuously.However.how can you translate a good target text quickly and accurately?We should master transhtion skills and seep basic steps in translating.As the matter of fact,translation is expressed language actives through using a language to another language exchanged with the accuracy and integrity of thinking.Some call it an art,and yet some others take it as a career.but no matter what the purpose is,the process oftranslation has its certain steps.A translator will have to understand the source text fust.and then conduct her/his translation and then,proofread the source text.In addition,translation standard,which is Faithfulness,Expressiveness,Elegance,phy an important role in the translation process.A brief analysis of the problems mentioned above is made.

  17. A Brief Investigation of Pre-reading Exercises in SEFC

    Institute of Scientific and Technical Information of China (English)

    XU Chu-juan

    2015-01-01

    As in reading teaching, schema theory has long been taking a dominant part. According to this theory, English teachers can help the students to call up their prior knowledge by placing an emphasis on a more efficient use of pre-reading activities. One of the effective activities is to make good use of the pre-reading exercises in the textbook. This paper intends to analyze the results of two brief investigations. One was about the pre-reading exercises in the SEFC (New Edition 2010) Book 1 . The other was car⁃ried out among the first year students from Nanhai Experimental High School of South China Normal University. English teachers in high school thus can train the students to make links between the text and what they already know according to their interests.

  18. Understanding hospitality house guests' needs: a brief case report.

    Science.gov (United States)

    Duncan, Mary Katherine Waibel

    2011-08-01

    A.E. Kazak's (2006) call to develop theory-driven and empirically supported programs aimed at strengthening the competencies of families affected by pediatric illness applies to both medical and nonmedical facilities and institutions that care for pediatric patients and their loved ones. M.K.W. Duncan and A. Blugis (in press, this issue) note that despite the intuitive and practical nature of Maslow's Hierarchy of Needs, no theory translates into an infallible understanding of any individual guest's needs or a program of universally applied best practice standards for meeting those needs. Using Maslow's theory as a framework, this brief report describes the complexity and fluidity of one mother's needs during her stay at a hospitality house following the birth of her premature twin babies.

  19. National briefing summaries: Nuclear fuel cycle and waste management

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K.J.; Lakey, L.T.; Silviera, D.J.

    1988-12-01

    The National Briefing Summaries is a compilation of publicly available information concerning the nuclear fuel cycle and radioactive waste management strategies and programs of 21 nations, including the United States and three international agencies that have publicized their activities in this field. It presents available highlight information with references that may be used by the reader for additional information. The information in this document is compiled primarily for use by the US Department of Energy and other US federal agencies and their contractors to provide summary information on radioactive waste management activities in other countries. This document provides an awareness to managers and technical staff of what is occurring in other countries with regard to strategies, activities, and facilities. The information may be useful in program planning to improve and benefit United States' programs through foreign information exchange. Benefits to foreign exchange may be derived through a number of exchange activities.

  20. A Brief Review of Chelators for Radiolabeling Oligomers

    Directory of Open Access Journals (Sweden)

    Yuxia Liu

    2010-05-01

    Full Text Available The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99mTc, 111In and 188Re. While DNA and its analogs have been radiolabeled with important radionuclides of nonmetals such as 32P, 35S, 14C, 18F and 125I, the labeling methods for these isotopes involve covalent chemistry that is quite distinct from the coordinate-covalent chelation chemistry described herein. In this review, we provide a summary of the several chelators that have been covalently conjugated to oligomers for the purpose of radiolabeling with metallic radionuclides by chelation and including details on the conjugation, the choice of radionuclides and labeling methods.

  1. SSNTD applications in science and technology - A brief review

    CERN Document Server

    Khan, H A

    1999-01-01

    The technique of Solid State Nuclear Track Detection (SSNTD) has matured since long as a viable method of charged particle detection. The usage of this method has been successfully extended to neutron detection and gamma dose measurements as well. The etch-track mechanism has been further exploited to generate a major application area of nuclear track filters. In spite of the remarkable diversity of SSNTD applications that have emerged over the years in different fields, its potential is by no means saturated. In this article, a brief review of SSNTD applications is presented with reference to contemporary interests in science and technology. For convenience, the coverage of topics is organized under broad categories of Nuclear Physics, Materials Research, Geology, Environmental Science and allied technologies. While identifying high interest areas, those with limited but innovative applications are also mentioned. In some cases, the important results are quoted for the purpose of illustrating the strength of...

  2. Quantum Feedback Networks and Control: A Brief Survey

    CERN Document Server

    Zhang, Guofeng

    2012-01-01

    The purpose of this paper is to provide a brief review of some recent developments in quantum feedback networks and control. A quantum feedback network (QFN) is an interconnected system consisting of open quantum systems linked by free fields and/or direct physical couplings. Basic network constructs, including series connections as well as feedback loops, are discussed. The quantum feedback network theory provides a natural framework for analysis and design. Basic properties such as dissipation, stability, passivity and gain of open quantum systems are discussed. Control system design is also discussed, primarily in the context of open linear quantum stochastic systems. The issue of physical realizability is discussed, and explicit criteria for stability, positive real lemma, and bounded real lemma are presented. Finally for linear quantum systems, coherent $H^\\infty$ and LQG control are described.

  3. A Brief Overview of the Civil Union Act

    Directory of Open Access Journals (Sweden)

    N Ntlama

    2010-05-01

    Full Text Available The adoption of the Constitution of the Republic of South Africa, 1996 (the Constitution has provided a sound framework for the elimination of discrimination and prejudice against all members of our society. The Constitution provides for equal recognition of the right to freedom of religion and sexual orientation within the framework of the right to equality. This note aims to provide a brief overview and analysis of the general and potentially problematic features of the Civil Union Act 17 of 2006 (the Act in the context of equality, generally and within realm of the constitutional protection afforded to everyone in South Africa. This contribution is limited to an examination of the quality of the legal protection accorded to same-sex couples as envisaged inthe Act, and not to an analysis of the nature of the institution of marriage itself or the theological and social dimensions of same-sex marriages.

  4. Memory for brief, widely spaced odor presentations in the rat.

    Science.gov (United States)

    Lovelace, C T; Slotnick, B M

    1995-04-01

    Rats trained on a series of 16 novel 2-odor discrimination tasks using a 10-s intertrial interval (ITI) rapidly improved in performance and made only 0-3 errors by the end of the test series. They were then tested on other novel pairs of odors, but with a 10- and a 30-min interval between trials. There was no decrement in performance accuracy in the longer ITI tests and, in most cases, criterion performance was achieved after making zero or 1 error after the first (information) trial. These results demonstrate that rats have the capacity to remember for at least 30 min whether a single brief presentation of a novel odor was followed by a reward.

  5. Mixing, spreading and reaction in heterogeneous media: a brief review.

    Science.gov (United States)

    Dentz, Marco; Le Borgne, Tanguy; Englert, Andreas; Bijeljic, Branko

    2011-03-01

    Geological media exhibit heterogeneities in their hydraulic and chemical properties, which can lead to enhanced spreading and mixing of the transported species and induce an effective reaction behavior that is different from the one for a homogeneous medium. Chemical heterogeneities such as spatially varying adsorption properties and specific reactive surface areas can act directly on the chemical reaction dynamics and lead to different effective reaction laws. Physical heterogeneities affect mixing-limited chemical reactions in an indirect way by their impact on spreading and mixing of dissolved species. To understand and model large-scale reactive transport the interactions of these coupled processes need to be understood and quantified. This paper provides a brief review on approaches of non-reactive and reactive transport modeling in geological media.

  6. A Brief Assessment for HIV Risk: The TCU HVHP Form

    Science.gov (United States)

    Rowan, Grace A.; Joe, George W.; Lehman, Wayne E. K.; Knight, Kevin

    2016-01-01

    Targeted HIV screens may help identify some risk-related concerns of drug-using offenders. The present study describes the Texas Christian University HIV/Hepatitis Risk Assessment (TCU HVHP) form, a 19-item self-report instrument measuring HIV and hepatitis risks based on a sample (N = 1,056) of offenders in eight prisons. Principal components analysis indicated four scales (Injection Risk, Condom Attitudes, Sex Risk, and AIDS Concern) with reliable psychometric properties with coefficient α reliabilities ranging from .72 to .88. Concurrent validities indicated the four scales were related to motivation for treatment, level of drug use, psychosocial functioning, and criminal thinking, although the patterns varied by gender. The TCU HVHP Form should be attractive to programs needing a brief assessment measuring HIV risk behaviors, attitudes toward condom use, and concerns about acquiring and transmitting HIV. PMID:27302708

  7. Energy predictions. [Briefs on 33 charts, figures, and graphs

    Energy Technology Data Exchange (ETDEWEB)

    Freiwald, D.A.

    1977-01-01

    Briefs describe 33 charts, graphs, and schematics offering some recent history and perspectives on the world and U.S. energy situation and the problems for survival facing the world. Of interest is Figure 28, showing the Club of Rome's model of the earth in terms of resource consumption, food, money, people, pollution, etc. A computer was asked to extend recent history into the future and results indicate a collapse of the industrialized system towards an agrarian culture around the year 2025. It is noted that the model did not consider technological initiative or man's willingness to change lifestyles. The final (33) schematic is a guesstimate of noticeable impact timescales, indicating when research projects on transition or ultimate energy sources at LASL might be expected to yield impact. (MCW)

  8. Understanding hospitality house guests' needs: a brief case report.

    Science.gov (United States)

    Duncan, Mary Katherine Waibel

    2011-08-01

    A.E. Kazak's (2006) call to develop theory-driven and empirically supported programs aimed at strengthening the competencies of families affected by pediatric illness applies to both medical and nonmedical facilities and institutions that care for pediatric patients and their loved ones. M.K.W. Duncan and A. Blugis (in press, this issue) note that despite the intuitive and practical nature of Maslow's Hierarchy of Needs, no theory translates into an infallible understanding of any individual guest's needs or a program of universally applied best practice standards for meeting those needs. Using Maslow's theory as a framework, this brief report describes the complexity and fluidity of one mother's needs during her stay at a hospitality house following the birth of her premature twin babies. PMID:21726783

  9. Pallet standards in agri-food sector: a brief survey

    Directory of Open Access Journals (Sweden)

    Alessandro Trevisani

    2014-10-01

    Full Text Available In food industry wooden pallet and fruit and vegetables crates are the most used for handling and delivering. Regulatory aspects and test procedure are relatively young as regards to the packaging sector of wooden. Currently many standards are in development or implementation. In this context the objective of the following paper is a brief overview on technical standards governing the use of wooden packaging, with particular reference to the agricultural-food sector. In this review, as wooden packaging, are taken into account, wood or its derivatives used to support, packaging and transport goods, such as cages, wooden pallets, wooden frame, wooden kegs, rods or timber. Particularly European standards are briefly described in their technical content and historic development. Market data, emerging technology and environmental problems are even recalled.

  10. Teaching family medicine residents brief interventions for alcohol misuse.

    Science.gov (United States)

    Rule, J Chris; Samuel, Pearl

    2015-01-01

    Across the lifespan, alcohol misuse affects a large percentage of patients seen in primary care clinics. It can lead to alcohol use disorders, ranging from risky use to alcohol dependence. Alcohol use disorders frequently complicate acute and chronic illnesses of patients seen in FM clinics. Screening patients for alcohol and substance use has become a standard of practice in most primary care settings. This report describes how a family medicine residency program solidified a residency curriculum in substance abuse screening, assessment, and brief intervention by merging three presentation-style didactics into a blended approach. The curriculum combines didactic teaching, motivational interviewing, and behavioral rehearsal of clinical practice skills. Qualitative feedback suggests that the curriculum has been successful in exposing residents to a variety of practical assessment methods and, through rehearsal, has improved resident confidence in addressing alcohol use and misuse in a primary care population. PMID:26130770

  11. Learning from traumatic experiences with brief eclectic psychotherapy for PTSD

    Directory of Open Access Journals (Sweden)

    Berthold P. R. Gersons

    2013-12-01

    Full Text Available Brief eclectic psychotherapy for PTSD (BEPP is an evidence-based therapeutic approach that combines and integrates elements from psychodynamic, cognitive-behavioral, and directive psychotherapy. Psychoeducation is done jointly with the patient and his or her partner. Exposure, a structured writing task, and memorabilia are used to help patients accessing, feeling and expressing their suppressed emotions related to the traumatic experience. In the domain of meaning stage, patients will learn how they and their view of the world have changed, and that they have become “sadder but wiser”. Much emphasis is put on the vulnerability of human beings. Finally, an individually tailored farewell ritual is done to end treatment, to reunite with loved ones, and to go on with life.For the abstract or full text in other languages, please see Supplementary files under Article Tools online

  12. Uncovering Interaction Structures in a Brief Psychodynamic Psychotherapy

    Directory of Open Access Journals (Sweden)

    Fernanda Barcellos Serralta

    2016-08-01

    Full Text Available Abstract Interaction structures refers to the repetitive ways of interaction between the patient-therapist dyad over the course of treatment. This construct is operationalized by the repeated application of the Psychotherapy Process Q-Set (PQS to psychotherapy sessions. Studies in this line of research have so far focused only on long-term treatment. The present study examines whether interaction structures can be detected empirically in short-term psychotherapies. All sessions (N = 31 of a successful case of brief psychodynamic psychotherapy were coded with the Psychotherapy Process Q-Set (PQS. The application of Q type factor analysis procedures with varimax rotation revealed five interaction structures: resistance, alliance, facing depression, expectation of change, and introspection and hearing. The analysis of variation of these structures over the course of the treatment showed that these interactions are nonlinear, may be positively or negatively protruding in different sessions, or be predominant at some treatment phase.

  13. Brief, embedded, spontaneous metacognitive talk indicates thinking like a physicist

    CERN Document Server

    Sayre, Eleanor C

    2014-01-01

    Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think "thinking like a physicist" entails. Through discourse analysis of upper-division students' speech in natural settings, we show that students may appropriate or resist these elements. We identify a new element in the physicist speech genre: brief, embedded, spontaneous metacognitive talk (BESM talk). BESM talk communicates students' in-the-moment enacted expectations about physics as a technical field and a cultural endeavor. Students use BESM talk to position themselves as physicists or non-physicists. Students also use BESM talk to communicate their expectations in four ways: understanding, confusion, spotting inconsistencies, and generalized expectations.

  14. Brief, embedded, spontaneous metacognitive talk indicates thinking like a physicist

    Science.gov (United States)

    Sayre, Eleanor C.; Irving, Paul W.

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] Instructors and researchers think "thinking like a physicist" is important for students' professional development. However, precise definitions and observational markers remain elusive. We reinterpret popular beliefs inventories in physics to indicate what physicists think thinking like a physicist entails. Through discourse analysis of upper-division students' speech in natural settings, we show that students may appropriate or resist these elements. We identify a new element in the physicist speech genre: brief, embedded, spontaneous metacognitive talk (BESM talk). BESM talk communicates students' in-the-moment enacted expectations about physics as a technical field and a cultural endeavor. Students use BESM talk to position themselves as physicists or nonphysicists. Students also use BESM talk to communicate their expectations in four ways: understanding, confusion, spotting inconsistencies, and generalized expectations.

  15. Legal Briefing: Mandated Reporters and Compulsory Reporting Duties.

    Science.gov (United States)

    Pope, Thaddeus Mason

    2016-01-01

    This issue's "Legal Briefing" column, one product of a Greenwall Foundation grant, reviews recent developments concerning compulsory reporting duties. Most licensed clinicians in the United States are "mandated reporters." When these clinicians discover certain threats to the safety of patients or the public, they are legally required to report that information to specified government officials. Over the past year, several states have legislatively expanded the scope of these reporting duties. In other states, new court cases illustrate the vigorous enforcement of already existing duties. I have organized all these legal developments into the following eight categories: 1. Overview of Mandatory Reporting Duties 2. Controversy over the Benefits of Mandatory Reporting 3. New and Expanded Duties to Report 4. Criminal Penalties for Failing to Report 5. Civil Liability for Failing to Report 6. Disciplinary Penalties for Failing to Report 7. Legal Immunity for Good-Faith Reporting 8. Protection against Employers' Retaliation. PMID:27045312

  16. Bourdieu at the bedside: briefing parents in a pediatric hospital.

    Science.gov (United States)

    LeGrow, Karen; Hodnett, Ellen; Stremler, Robyn; McKeever, Patricia; Cohen, Eyal

    2014-12-01

    The philosophy of family-centered care (FCC) promotes partnerships between families and staff to plan, deliver, and evaluate services for children and has been officially adopted by a majority of pediatric hospitals throughout North America. However, studies indicated that many parents have continued to be dissatisfied with their decision-making roles in their child's care. This is particularly salient for parents of children with chronic ongoing complex health problems. These children are dependent upon medical technology and require frequent hospitalizations during which parents must contribute to difficult decisions regarding their child's care. Given this clinical issue, an alternative theoretical perspective was explored to redress this problem. Pierre Bourdieu's theoretical concepts of field, capital, and habitus were used to analyze the hierarchical relationships in pediatric acute care hospitals and to design a briefing intervention aimed at improving parents' satisfaction with decision making in that health care setting.

  17. Biofield therapies in cardiovascular disease management: a brief review.

    Science.gov (United States)

    Anderson, Joel G; Taylor, Ann Gill

    2011-01-01

    Though there have been advances over the last 30 years in the therapeutic approaches to cardiovascular disease (CVD), heart disease and stroke remain the leading cause of mortality and morbidity worldwide. Many medical therapies for CVD are associated with a number of side effects, often leading patients to seek non-pharmacological treatments to complement standard care. Referred to as complementary and alternative medicine (CAM), these therapies consist of a heterogeneous group of modalities used in addition to conventional health care. Biofield therapies exist within this CAM domain and involve the direction of healing energy to facilitate general health and well-being by modifying the energy field. What follows is a brief overview of three biofield therapies developed or used within the field of nursing (Therapeutic Touch, Reiki, and Healing Touch), surveying the use of these interventions for individuals with CVD, and outcomes that may impact CVD risk factors and health-related quality of life. PMID:21697661

  18. Applications of Fuzzy Logic in Image Processing – A Brief

    Directory of Open Access Journals (Sweden)

    Mahesh Prasanna K

    2015-10-01

    Full Text Available  The subject of this study is to show the application of fuzzy logic in image processing with a brief introduction to fuzzy logic and digital image processing. Digital image processing is an ever expanding and dynamic area with applications reaching out into our everyday life such as medicine, space exploration, surveillance, authentication, automated industry inspection and many more areas. Fuzzy logic, one of the decision-making techniques of artificial intelligence, has many application areas. Although it has been subjected to criticisms since its birth, especially in recent years, fuzzy logic has been proven to be applicable in almost all scientific fields. This shows that the concept of fuzzy logic will maintain its validity and the number of fields where it draws attention will increase further.

  19. Bourdieu at the bedside: briefing parents in a pediatric hospital.

    Science.gov (United States)

    LeGrow, Karen; Hodnett, Ellen; Stremler, Robyn; McKeever, Patricia; Cohen, Eyal

    2014-12-01

    The philosophy of family-centered care (FCC) promotes partnerships between families and staff to plan, deliver, and evaluate services for children and has been officially adopted by a majority of pediatric hospitals throughout North America. However, studies indicated that many parents have continued to be dissatisfied with their decision-making roles in their child's care. This is particularly salient for parents of children with chronic ongoing complex health problems. These children are dependent upon medical technology and require frequent hospitalizations during which parents must contribute to difficult decisions regarding their child's care. Given this clinical issue, an alternative theoretical perspective was explored to redress this problem. Pierre Bourdieu's theoretical concepts of field, capital, and habitus were used to analyze the hierarchical relationships in pediatric acute care hospitals and to design a briefing intervention aimed at improving parents' satisfaction with decision making in that health care setting. PMID:24467272

  20. Brief mindfulness meditation improves mental state attribution and empathizing.

    Directory of Open Access Journals (Sweden)

    Lucy B G Tan

    Full Text Available The ability to infer and understand the mental states of others (i.e., Theory of Mind is a cornerstone of human interaction. While considerable efforts have focused on explicating when, why and for whom this fundamental psychological ability can go awry, considerably less is known about factors that may enhance theory of mind. Accordingly, the current study explored the possibility that mindfulness-based meditation may improve people's mindreading skills. Following a 5-minute mindfulness induction, participants with no prior meditation experience completed tests that assessed mindreading and empathic understanding. The results revealed that brief mindfulness meditation enhanced both mental state attribution and empathic concern, compared to participants in the control group. These findings suggest that mindfulness may be a powerful technique for facilitating core aspects of social-cognitive functioning.

  1. National briefing summaries: Nuclear fuel cycle and waste management

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K.J.; Bradley, D.J.; Fletcher, J.F.; Konzek, G.J.; Lakey, L.T.; Mitchell, S.J.; Molton, P.M.; Nightingale, R.E.

    1991-04-01

    Since 1976, the International Program Support Office (IPSO) at the Pacific Northwest Laboratory (PNL) has collected and compiled publicly available information concerning foreign and international radioactive waste management programs. This National Briefing Summaries is a printout of an electronic database that has been compiled and is maintained by the IPSO staff. The database contains current information concerning the radioactive waste management programs (with supporting information on nuclear power and the nuclear fuel cycle) of most of the nations (except eastern European countries) that now have or are contemplating nuclear power, and of the multinational agencies that are active in radioactive waste management. Information in this document is included for three additional countries (China, Mexico, and USSR) compared to the prior issue. The database and this document were developed in response to needs of the US Department of Energy.

  2. National briefing summaries: Nuclear fuel cycle and waste management

    International Nuclear Information System (INIS)

    Since 1976, the International Program Support Office (IPSO) at the Pacific Northwest Laboratory (PNL) has collected and compiled publicly available information concerning foreign and international radioactive waste management programs. This National Briefing Summaries is a printout of an electronic database that has been compiled and is maintained by the IPSO staff. The database contains current information concerning the radioactive waste management programs (with supporting information on nuclear power and the nuclear fuel cycle) of most of the nations (except eastern European countries) that now have or are contemplating nuclear power, and of the multinational agencies that are active in radioactive waste management. Information in this document is included for three additional countries (China, Mexico, and USSR) compared to the prior issue. The database and this document were developed in response to needs of the US Department of Energy

  3. EU TYPE OF AUSTERITY: BRIEF ANALYSIS AND CRITICISM

    Directory of Open Access Journals (Sweden)

    IONELA BALTATESCU

    2014-11-01

    Full Text Available Although it has become a common place to blame austerity policies for lengthening the economic downturn of EU economies, the figures reveal that public spending increased in most of the EU countries between 2007 and 2013. Although budget deficits from EU countries were indeed reduced in the last 4 years, the cutbacks were more the result of increasing government revenues and hiking taxes than of decreasing public expenditures. The article will feature: (1 a brief analysis of the evolution of public spending compared to government revenues in EU countries and also, (2 a concise literature review on austerity, highlighting some of the most important theoretical controversies on this topic. The main thesis defended in the article is that – although EU type of austerity, narrowly focusing on fiscal consolidation, drove indeed to unfavorable economic consequences – the criticism formulated by pro stimulus economists is rather flimsy, given the fact that public expenditures actually increased in most of the EU countries.

  4. Brief guidelines for methods and statistics in medical research

    CERN Document Server

    Ab Rahman, Jamalludin

    2015-01-01

    This book serves as a practical guide to methods and statistics in medical research. It includes step-by-step instructions on using SPSS software for statistical analysis, as well as relevant examples to help those readers who are new to research in health and medical fields. Simple texts and diagrams are provided to help explain the concepts covered, and print screens for the statistical steps and the SPSS outputs are provided, together with interpretations and examples of how to report on findings. Brief Guidelines for Methods and Statistics in Medical Research offers a valuable quick reference guide for healthcare students and practitioners conducting research in health related fields, written in an accessible style.

  5. National briefing summaries: Nuclear fuel cycle and waste management

    International Nuclear Information System (INIS)

    The National Briefing Summaries is a compilation of publicly available information concerning the nuclear fuel cycle and radioactive waste management strategies and programs of 21 nations, including the United States and three international agencies that have publicized their activities in this field. It presents available highlight information with references that may be used by the reader for additional information. The information in this document is compiled primarily for use by the US Department of Energy and other US federal agencies and their contractors to provide summary information on radioactive waste management activities in other countries. This document provides an awareness to managers and technical staff of what is occurring in other countries with regard to strategies, activities, and facilities. The information may be useful in program planning to improve and benefit United States' programs through foreign information exchange. Benefits to foreign exchange may be derived through a number of exchange activities

  6. Brief behavioral treatment for patients with treatment-resistant insomnia

    Directory of Open Access Journals (Sweden)

    Wang J

    2016-08-01

    Full Text Available Jihui Wang, Qinling Wei, Xiaoli Wu, Zhiyong Zhong, Guanying Li Department of Psychiatry, The Third Affiliated Hospital of Sun-Yat Sen University, Guangzhou, Guangdong, People’s Republic of China Objective: To evaluate the efficacy of brief behavioral treatment for insomnia (BBTI in treating patients with treatment-resistant insomnia.Methods: Seventy-nine adults with treatment-resistant insomnia were randomly assigned to receive either individualized BBTI (delivered in two in-person sessions and two telephone “booster” sessions, n=40 or sleep hygiene education (n=39. The primary outcome was sub­jective (sleep diary measures of self-report symptoms and questionnaire measures of Pittsburgh sleep quality index (PSQI, insomnia severity index (ISI, Epworth sleeping scale (ESS, and dysfunctional beliefs and attitudes about sleep scale (DBAS.Results: The repeated-measures analysis of variance showed significant time effects between pretreatment and posttreatment in the scale ratings of PSQI, ESS, DBAS, ISI, sleep latency (SL, time in bed (TIB, sleep efficiency (SE, and wake after sleep onset (WASO in both groups and group × time interaction (FPSQI =3.893, FESS =4.500, FDBAS =5.530, FISI =15.070, FSL =8.909, FTIB =7.895, FSE =2.926, and FWASO =2.595. The results indicated significant differences between BBTI and sleep hygiene in change scores of PSQI, ESS, DBAS, ISI, SL, TIB, SE, and WASO. Effect sizes were moderate to large.Conclusion: BBTI is a simple and efficacious intervention for chronic insomnia in adults. Keywords: brief behavioral treatment, treatment-resistant, insomnia

  7. Policy Brief: Shale Gas in India: Look Before You Leap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-15

    Natural gas forms 9 per cent of the total commercial energy mix in India, but demand far exceeds supply, as shown in Figure 1. Part of the demand in 2012–13 was made up by the import of liquefied natural gas (LNG) to the extent of 18 bcm. Several power plants, which were in operation, or ready for commissioning, or in an advanced state of construction, representing about 10,000 MW of generation capacity, were, however, idle for want of gas. The exploration and production of shale gas in the United States (US) has been a game changer, making the country self-sufficient in natural gas over the last few years. This has created considerable excitement globally, particularly in Europe. India is also looking at exploring shale gas domestically to fill in the supply–demand gap. But will what works for the US also work for Europe and India? This policy brief explores this question in the context of India. It explains the nature of shale gas, the technology for its extraction from underground sources, and its potential for India. It also highlights overseas acquisitions of this resource by Indian companies even before it is sourced domestically, and then examines the viability of the technology in India. One of the key determinants of the viability of this technology is the availability of large quantities of clean water. This policy brief raises a red flag on this complementary input for exploiting shale gas resources in India, given that India is a water stressed country, and is fast approaching water scarcity conditions.

  8. Screening and brief intervention for alcohol and other abuse.

    Science.gov (United States)

    Harris, Sion Kim; Louis-Jacques, Jennifer; Knight, John R

    2014-04-01

    Substance use is the most common health risk behavior among adolescents and is one of the greatest threats to their current and future health. Universal screening of adolescents in general medical settings can be instrumental in identifying substance use early, before further problems develop and when BIs are more likely to be effective. Screening in and of itself may have some therapeutic effect. Brief screening tools feasible for use by busy medical offices to quickly and reliably assess adolescent risk for a substance use disorder now are available. A recent study found that a physician-conducted CRAFFT screen interview required an average of 74 seconds to complete, whereas a computer self-administered version took an average of 49 seconds. The CRAFFT and AUDIT tools currently have the most evidence for validity among adolescents, whereas the validity of other widely used tools such as DAST-10, NIDA-modified ASSIST (Alcohol, Smoking and Substance Involvement Screening Test), and ultra-brief screens (AUDIT-C, single-item screens) has yet to be established for adolescents. Studies are needed to identify effective strategies to promote universal adolescent screening and the use of valid screening tools in general medical settings. One statewide (Massachusetts) study found that although most (86%) primary care physicians seeing adolescents reported screening adolescents for substance use annually, only 1 in 3 reported using a validated tool (the CRAFFT). The remaining physicians reporting using informal screening procedures, their own questionnaire, or the CAGE. Computerization of screening and integration into the electronic health record appear to be promising strategies to promote universal screening and standardized use of valid screening tools. Increasing adolescent screening rates necessitates supporting physicians' ability to respond effectively to the screen results. To that end, recent evidence-informed practice guides from the AAP and NIAAA provide a

  9. The Effect of Brief Functional Relaxation on College Students' Needle Anxiety during Injected Vaccinations

    Science.gov (United States)

    McWhorter, Linda G.; Gil-Rivas, Virginia

    2014-01-01

    Objective: This study examined the effect of brief functional relaxation (FR) training on needle anxiety (NA) during vaccinations. Participants: From October 2010 through May 2012, 48 undergraduates were recruited through the psychology research participant pool. Methods: Students (N = 48) were randomly assigned to a 15-minute brief FR session…

  10. Graduate Employment Gap: Students of Color Losing Ground. EPI Briefing Paper #282

    Science.gov (United States)

    Austin, Algernon

    2010-01-01

    This Briefing Paper explores the racial and ethnic variation in the employment situation for recent high school and college graduates. For 16 to 24 year olds, this Briefing Paper finds: (1) In the first half of 2007, even before the recession began, one in five black high school graduates were unemployed; (2) By the first half of this year, the…

  11. Clinicians' Perspectives on Motivational Interviewing-Based Brief Interventions in College Health

    Science.gov (United States)

    Rash, Elizabeth M.

    2008-01-01

    Brief interventions based on motivational interviewing (MI) are emerging as effective strategies for behavior change in college students. However, implementation of MI-based brief interventions may be challenging in the college health environment, and their practicality is controversial. The author explored college health clinicians' perspectives…

  12. Disrupting the flow : How brief silences in group conversations affect social needs

    NARCIS (Netherlands)

    Koudenburg, Namkje; Postmes, Tom; Gordijn, Ernestine H.

    2011-01-01

    We all know the awkward feeling when a conversation is disrupted by a brief silence. This paper studies why such moments can be unsettling. We suggest that silences are particularly disturbing if they disrupt the conversational flow. In two experiments we examined the effects of a single brief insta

  13. Math Placement: The Importance of Getting It Right for All Students. Research Brief

    Science.gov (United States)

    Fong, Anthony; Finkelstein, Neal

    2014-01-01

    Given the Common Core State Standards for Mathematics, California's history of math acceleration in the middle grades, and the concern for correct math course placement for all students, this brief examines patterns from the past to shed light on considerations for the future. The brief, written by WestEd's Tony Fong and Neal Finkelstein, presents…

  14. Brief narrative exposure therapy for posttraumatic stress in Iraqi refugees: a preliminary randomized clinical trial.

    Science.gov (United States)

    Hijazi, Alaa M; Lumley, Mark A; Ziadni, Maisa S; Haddad, Luay; Rapport, Lisa J; Arnetz, Bengt B

    2014-06-01

    Many Iraqi refugees suffer from posttraumatic stress. Efficient, culturally sensitive interventions are needed, and so we adapted narrative exposure therapy into a brief version (brief NET) and tested its effects in a sample of traumatized Iraqi refugees. Iraqi refugees in the United States reporting elevated posttraumatic stress (N = 63) were randomized to brief NET or waitlist control conditions in a 2:1 ratio; brief NET was 3 sessions, conducted individually, in Arabic. Positive indicators (posttraumatic growth and well-being) and symptoms (posttraumatic stress, depressive, and somatic) were assessed at baseline and 2- and 4-month follow-up. Treatment participation (95.1% completion) and study retention (98.4% provided follow-up data) were very high. Significant condition by time interactions showed that those receiving brief NET had greater posttraumatic growth (d = 0.83) and well-being (d = 0.54) through 4 months than controls. Brief NET reduced symptoms of posttraumatic stress (d = -0.48) and depression (d = -0.46) more, but only at 2 months; symptoms of controls also decreased from 2 to 4 months, eliminating condition differences at 4 months. Three sessions of brief NET increased growth and well-being and led to symptom reduction in highly traumatized Iraqi refugees. This preliminary study suggests that brief NET is both acceptable and potentially efficacious in traumatized Iraqi refugees.

  15. A Brief Comparative Study of the Translation Theories by Nida and New-mark

    Institute of Scientific and Technical Information of China (English)

    李奕

    2016-01-01

    Nida and Newmark are the two of the most distinguished contemporary translation theorist in the west. A brief compar-ative study was made on their translation theories by giving a general survey of their life, then a brief introduction of their theo-ries and comparing the differences.

  16. Conceptualizing an Agenda for Social Responsibility and Public Policy at Montgomery College. A Briefing Paper. Revised

    Science.gov (United States)

    Scott, Michelle T.

    2007-01-01

    The purpose of this briefing paper is to conceptualize a social responsibility and public policy agenda for Montgomery College. The briefing paper provides (a) a well researched perspective to embed a College culture to actualize social responsibility and public policy as institutional practices; (b) examines some of the opportunities and…

  17. Gender Brief on ADRA (Adventist Development and Relief Organisation) in Rwanda

    DEFF Research Database (Denmark)

    Madsen, Diana Højlund

    The Gender Brief is based on focus groups interviews in Rwanda on the gender perspectives of ADRA-Rwanda and gives recommendations for the organisation.......The Gender Brief is based on focus groups interviews in Rwanda on the gender perspectives of ADRA-Rwanda and gives recommendations for the organisation....

  18. School Counselors' Adoption of Brief Counseling: The Diffusion of an Innovative Practice

    Science.gov (United States)

    Littrell, John M.; Carlson, Laurie

    2009-01-01

    Brief counseling has emerged as an innovation in the field of school counseling. This study examined the factors that promote and impede the adoption of such innovation. Everett Rogers' diffusion of innovation model provided the framework for the survey examining counselors' knowledge, application skills, and actual use of brief counseling. The…

  19. Effects of Varying Session Length and Frequency in Brief Emotive Psychotherapy

    Science.gov (United States)

    Bierenbaum, Howard; And Others

    1976-01-01

    This study examined the role of emotional catharsis in brief emotive psychotherapy and its differential effects within three time frames. The findings are seen as supporting the contention that within a specific time frame emotional catharsis can lead to certain positive outcomes in brief emotive psychotherapy. (Author)

  20. Screening High School Students for Eating Disorders: Validity of Brief Behavioral and Attitudinal Measures

    Science.gov (United States)

    Haines, Jess; Ziyadeh, Najat J.; Franko, Debra L.; McDonald, Julia; Mond, Jonathan M.; Austin, S. Bryn

    2011-01-01

    Background: Early identification can greatly impact the trajectory of eating disorders, and school-based screening is 1 avenue for identifying those at risk. To be feasible in a school setting, a screening program must use a brief, valid screening tool. The aim of this study was to assess how well brief attitudinal and behavioral survey items…

  1. Do Nurse Home-Visiting Programs Have Lasting Benefits for Mothers and Children? Evaluation Science Brief

    Science.gov (United States)

    National Forum on Early Childhood Program Evaluation, 2008

    2008-01-01

    "Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study, "Effects of Nurse Home-Visiting on Maternal and Child Functioning: Age-9 Follow-up of a Randomized Trial" (D. Olds, et al.). States are increasingly turning to…

  2. Can Professional Development for Teachers Enhance Language and Literacy Environments for Preschoolers? Evaluation Science Brief

    Science.gov (United States)

    National Forum on Early Childhood Program Evaluation, 2009

    2009-01-01

    "Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study, "Building Support for Language and Literacy in Preschool Classrooms through In-Service Professional Development: Effects of the Literacy Environment Enrichment…

  3. Even Low Levels of Alcohol during Pregnancy Can Affect Fetal Brain Development. Science Briefs

    Science.gov (United States)

    National Scientific Council on the Developing Child, 2008

    2008-01-01

    "Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This brief reports on the study "Effects of Prenatal Alcohol Exposure on GABAergic Neurons" (V. C. Cuzone; P. W. L. Yeh; Y. Yanagawa; K. Obata; and H. H. Yeh). Study results indicate that even exposure to low levels of alcohol during…

  4. Brief cognitive behavior therapy in patients with social anxiety disorder: A preliminary investigation

    Directory of Open Access Journals (Sweden)

    Ravikant G Pinjarkar

    2015-01-01

    Full Text Available Context: Cognitive behavior therapy (CBT is the treatment of choice in anxiety disorders. However, there is little evidence for the effectiveness brief CBT in social anxiety. Aims: We examined the effectiveness of a brief CBT of six sessions in patients with social anxiety disorder. Settings and Design: A single case design study baseline; post and 1 month follow-up was adopted. Materials and Methods: Seven patients with a DSM IV diagnosis of social anxiety underwent 6 weekly sessions of brief CBT. Their diagnosis was confirmed using structured diagnostic interviews. They were assessed at baseline, post and 1-month follow-up on CGI- Severity, Leibowitz Social Anxiety Scale (LSAS, Social Phobia Rating Scale, Brief Fear of Negative Evaluation, and Beck′s Depression Inventory. Statistical Analysis: Data were analyzed using the method of clinical significance. Results: Results indicated that brief CBT was effective in reducing social anxiety in all patients. Brief CBT was also effective in reducing social avoidance and self consciousness. However, brief CBT was not effective in reducing fear of negative evaluation in all patients, suggesting the need for longer duration for cognitive changes in some dysfunctional beliefs. Conclusions: This preliminary case series indicates that brief CBT may be a promising and a cost and time effective approach to managing for social anxiety.

  5. Evaluation of the Brief Problem Checklist: Child and Caregiver Interviews to Measure Clinical Progress

    Science.gov (United States)

    Chorpita, Bruce F.; Reise, Steven; Weisz, John R.; Grubbs, Kathleen; Becker, Kimberly D.; Krull, Jennifer L.

    2010-01-01

    Objective: To support ongoing monitoring of child response during treatment, we sought to develop a brief, easily administered, clinically relevant, and psychometrically sound measure. Method: We first developed child and caregiver forms of a 12-item Brief Problem Checklist (BPC) interview by applying item response theory and factor analysis to…

  6. 14 CFR 302.30 - Briefs to the administrative law judge.

    Science.gov (United States)

    2010-01-01

    ... may, upon request and under such conditions as the administrative law judge may prescribe, file for... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Briefs to the administrative law judge. 302... Applicability Oral Evidentiary Hearing Proceedings § 302.30 Briefs to the administrative law judge. Within...

  7. Brief, Early Treatment for ASD/PTSD Following Motor Vehicle Accidents

    Science.gov (United States)

    Hickling, Edward J.; Blanchard, Edward B.; Kuhn, Eric

    2005-01-01

    Early, brief interventions for posttraumatic stress disorder (PTSD) secondary to motor vehicle accidents (MVAs) have historically been, with few exceptions, unsuccessful with single session or even very brief (3 to 6 sessions) interventions. In contrast, very intensive cognitive behavioral therapy (CBT) applied over the first 6 to 8 weeks…

  8. Ten Year Revision of the Brief Behavioral Activation Treatment for Depression: Revised Treatment Manual

    Science.gov (United States)

    Lejuez, C. W.; Hopko, Derek R.; Acierno, Ron; Daughters, Stacey B.; Pagoto, Sherry L.

    2011-01-01

    Following from the seminal work of Ferster, Lewinsohn, and Jacobson, as well as theory and research on the Matching Law, Lejuez, Hopko, LePage, Hopko, and McNeil developed a reinforcement-based depression treatment that was brief, uncomplicated, and tied closely to behavioral theory. They called this treatment the brief behavioral activation…

  9. Do Early Childhood Programs Have Lasting Effects on Children? Evaluation Science Brief

    Science.gov (United States)

    National Forum on Early Childhood Program Evaluation, 2008

    2008-01-01

    "Evaluation Science Briefs" summarize the findings and implications of a recent study evaluating the effects of an early childhood program or environment. This Brief evaluates the study "Early Intervention in Low Birthweight Premature Infants: Results at 18 Years of Age for the Infant Health and Development Program (IHDP)" (M.C. McCormick, J.…

  10. Executive functioning in children with ASD: an analysis of the BRIEF.

    Science.gov (United States)

    Blijd-Hoogewys, E M A; Bezemer, M L; van Geert, P L C

    2014-12-01

    The Behavior Rating Inventory of Executive Functions (BRIEF) screens for executive function deficits in 5- to 18-year-olds. Data of three autism subgroups, according to DSM-IV-TR criteria (N = 35 Autistic Disorder, N = 27 Asperger's Disorder and N = 65 PDD-NOS), were analyzed. The total group has elevated scores on almost all BRIEF scales. The Shift scale is clinically elevated, reflecting a deficit in cognitive flexibility. The BRIEF scales are not found to discriminate among the autism spectrum disorder (ASD) subgroups. The relation between BRIEF and IQ is complex. Possible influencing factors are discussed. Finally, it is recommended to omit the Negativity scale as a validity index in children with ASD and to consider a high score on this index as a unique characteristic of their BRIEF profile, reflecting rigidity problems. PMID:24996868

  11. Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors.

    Science.gov (United States)

    Chang, Chun Yun; Esber, Guillem R; Marrero-Garcia, Yasmin; Yau, Hau-Jie; Bonci, Antonello; Schoenbaum, Geoffrey

    2016-01-01

    Correlative studies have strongly linked phasic changes in dopamine activity with reward prediction error signaling. But causal evidence that these brief changes in firing actually serve as error signals to drive associative learning is more tenuous. Although there is direct evidence that brief increases can substitute for positive prediction errors, there is no comparable evidence that similarly brief pauses can substitute for negative prediction errors. In the absence of such evidence, the effect of increases in firing could reflect novelty or salience, variables also correlated with dopamine activity. Here we provide evidence in support of the proposed linkage, showing in a modified Pavlovian over-expectation task that brief pauses in the firing of dopamine neurons in rat ventral tegmental area at the time of reward are sufficient to mimic the effects of endogenous negative prediction errors. These results support the proposal that brief changes in the firing of dopamine neurons serve as full-fledged bidirectional prediction error signals.

  12. Fermi/GBM Observations of SGRJ0501 + 4516 Bursts

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; Baring, Matthew G.; van der Horst, Alexander J.; Guiriec, Sylvain; Woods, Peter M.; Goegues, Ersin; Kaneko, Yuki; Scargle, Jeffrey; Granot, Jonathan; Preece, Robert; von Kienlin, Andreas; Chaplin, Vandiver; Watts, Anna L.; Wijers, Ralph A. M. J.; Zhang, Shuang Nan; Bhat, Narayan; Finger, Mark H.; Gehrels. Neil; Harding, Alice; Kaper, Lex; Kaspi, Victoria; Mcenery, Julie; Meegan, Charles A.; Wilson-Hodge, Colleen

    2011-01-01

    We present our temporal and spectral analyses of 29 bursts from SGRJ0501+4516, detected with the Gamma-ray Burst Monitor onboard the Fermi Gamma-ray Space Telescope during the 13 days of the source activation in 2008 (August 22 to September 3). We find that the T(sub 90) durations of the bursts can be fit with a log-normal distribution with a mean value of approx. 123 ms. We also estimate for the first time event durations of Soft Gamma Repeater (SGR) bursts in photon space (i.e., using their deconvolved spectra) and find that these are very similar to the T(sub 90)s estimated in count space (following a log-normal distribution with a mean value of approx. 124 ms). We fit the time-integrated spectra for each burst and the time-resolved spectra of the five brightest bursts with several models. We find that a single power law with an exponential cutoff model fits all 29 bursts well, while 18 of the events can also be fit with two black body functions. We expand on the physical interpretation of these two models and we compare their parameters and discuss their evolution. We show that the time-integrated and time-resolved spectra reveal that E(sub peak) decreases with energy flux (and fluence) to a minimum of approx. 30 keV at F = 8.7 x 10(exp -6)erg/sq cm/s, increasing steadily afterwards. Two more sources exhibit a similar trend: SGRs J1550 - 5418 and 1806 - 20. The isotropic luminosity, L(sub iso), corresponding to these flux values is roughly similar for all sources (0.4 - l.5 x 10(exp 40) erg/s.

  13. Reinvigorating GBM Research with Hope for Therapies - TCGA

    Science.gov (United States)

    Dr. Antonio Iavarone and his research group at Columbia University have discovered the first recurrent gene fusion in glioblastoma. Find out how they did it and potential implications in this Case Study.

  14. Press briefing on results from the solar spacecraft SOHO

    Science.gov (United States)

    1998-04-01

    After its launch on 2 December 1995, SOHO travelled to take up a special orbit 1.5 million kilometres away on the sunward side of the Earth, where the Sun never sets. The full scientific programme began in April 1996. The occasion for the briefing is the celebration of that second anniversary and of the mission's extension to 2003. Organized by the European Space Agency, the briefing will be hosted by the Rutherford Appleton Laboratory, which is near Oxford. Leading scientists associated with SOHO will announce to the press some remarkable new discoveries about the Sun's interior, atmosphere and solar wind. They will also briefly review the main achievements of the past two years. The role of SOHO as the chief watchdog for storms on the Sun that may affect the Earth will be demonstrated. Europe's creation of the finest spacecraft ever built to observe the Sun will be recalled by a top engineer from ESA. A speaker from NASA will explain transatlantic contributions to SOHO, which is a project of international cooperation between ESA and NASA. ESA's director of science will also be present, to relate SOHO to ESA's general science programme. A lunch-time talk by the BNSC's director of science completes the line-up of speakers. This is also an exceptional opportunity for the press to meet and interview scientists from all over Europe and the USA, who are attending a meeting at the Rutherford Appleton Laboratory of SOHO's Science Working Team (SWT). Journalists are usually excluded from such meetings. The Rutherford Appleton Laboratory plays a prominent part in SOHO, particularly through its provision of the CDS ultraviolet spectrometer. A visit to the CDS group will provide a chance to see what space research is really like. Please indicate your intention to attend, on the accreditation form that follows the schedule. Guidance on how to get to the Rutherford Appleton Laboratory is appended. PROGRAMME Rutherford Appleton Laboratory (RAL), 28 April 1998 10:30 Assembly of

  15. Mean Field Games Models-A Brief Survey

    KAUST Repository

    Gomes, Diogo A.

    2013-11-20

    The mean-field framework was developed to study systems with an infinite number of rational agents in competition, which arise naturally in many applications. The systematic study of these problems was started, in the mathematical community by Lasry and Lions, and independently around the same time in the engineering community by P. Caines, Minyi Huang, and Roland Malhamé. Since these seminal contributions, the research in mean-field games has grown exponentially, and in this paper we present a brief survey of mean-field models as well as recent results and techniques. In the first part of this paper, we study reduced mean-field games, that is, mean-field games, which are written as a system of a Hamilton-Jacobi equation and a transport or Fokker-Planck equation. We start by the derivation of the models and by describing some of the existence results available in the literature. Then we discuss the uniqueness of a solution and propose a definition of relaxed solution for mean-field games that allows to establish uniqueness under minimal regularity hypothesis. A special class of mean-field games that we discuss in some detail is equivalent to the Euler-Lagrange equation of suitable functionals. We present in detail various additional examples, including extensions to population dynamics models. This section ends with a brief overview of the random variables point of view as well as some applications to extended mean-field games models. These extended models arise in problems where the costs incurred by the agents depend not only on the distribution of the other agents, but also on their actions. The second part of the paper concerns mean-field games in master form. These mean-field games can be modeled as a partial differential equation in an infinite dimensional space. We discuss both deterministic models as well as problems where the agents are correlated. We end the paper with a mean-field model for price impact. © 2013 Springer Science+Business Media New York.

  16. An Impact Evaluation of Two Versions of a Brief Intervention Targeting Alcohol Use and Physical Activity among Adolescents

    Science.gov (United States)

    Mathews, Anna E.; Werch, Chudley (CHAD); Michniewicz, Mara; Bian, Hui

    2007-01-01

    The purpose of the study was to evaluate the immediate impact of two new versions of the Project SPORT program, a brief one-on-one tailored consult addressing alcohol use and physical activity for adolescents. One new version was a brief interactive CD-ROM (Study one) and a second was a brief small group consultation (Study two). In study one,…

  17. Experiences of patients with borderline personality disorder with the brief admission intervention: a phenomenological study.

    Science.gov (United States)

    Helleman, Marjolein; Goossens, Peter J J; Kaasenbrood, Ad; van Achterberg, Theo

    2014-10-01

    Brief admission is a crisis intervention for patients with borderline personality disorder (BPD), and refers to a clinical admission at a psychiatric hospital for a period of 1-5 nights. Patients formulate a treatment plan together with their community mental health nurse about the maximum frequency allowed for these brief admissions. The purpose of the study was to describe the lived experiences of patients with BPD with use of the brief admission intervention. The study used a phenomenological approach. Inclusion criteria were a diagnosis of BPD, according to the Diagnostic and Statistical Manual of Mental Disorders-IV criteria; experience with brief admission, and sufficient understanding of the Dutch language. A total of 16 female patients and one male patient participated in the study. Thematic analysis of the transcripts of the interviews revealed four major meaning units: (i) organization of the brief admission; (ii) contact with a nurse; (iii) time out from daily life; and (iv) experienced value for the patient. Patients highlighted the quality of the contact with a nurse as the most important aspect of the brief admission. Nurses should be aware of the importance of connecting with patients who have BPD during a brief admission, particularly in light of the interpersonal hypersensitivity that characterizes these patients. PMID:24890615

  18. Wnt/Ca2+ signaling pathway: a brief overview

    Institute of Scientific and Technical Information of China (English)

    Antara De

    2011-01-01

    The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical counterpart,the Wnt/β-catenin pathway.The non-canonical Wnt signaling pathways are diverse,defined as planer cell polarity pathway,Wnt-RAP1 signaling pathway,Wnt-Ror2 signaling pathway,Wnt-PKA pathway,Wnt-GSK3MT pathway,Wnt-aPKC pathway,Wnt-RYK pathway,Wnt-mTOR pathway,and Wnt/calcium signaling pathway.All these pathways exhibit a considerable degree of overlap between them.The Wnt/Ca2+ signaling pathway was deciphered as a crucial mediator in development.However,now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena.Many aspects of Wnt/Ca2+ pathway are yet enigmatic.This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca2+ signaling pathway.

  19. A brief history of enviroethics and its challenges.

    Science.gov (United States)

    Laal, Marjan

    2009-01-01

    Environmental ethics has emerged during the early 1970s, when environmentalists started urging philosophers to consider the philosophical aspects of environmental problems. Environmental ethics considers the ethical relationships between humanity and non-human world. The Union of Concerned Scientists, a group of over two thousands scientists, has concluded that climatic change is beyond dispute, and already changing our environment. Environmental instability portend ill for public health and well-being. This paper attempts to apply ethical theories to support environmental concerns and provides moral grounds to preserve the earth's environment. This article documents consensus among environmental philosophers as given by synthesis data provided via survey among articles, websites, and books by the keywords: environment, ethics, health and crises. The field has come to exert significant influence over a large number of human science disciplines in relation to environmental sustainability and human wellbeing. Environmental ethics focuses on the possibility of the identification of human ego with nature, means the larger ecological self deserves respect, too. Environmental ethics expands the boundaries of ethics to include the nature and considers its sustainability to ensure human wellbeing. This study emphasizes mainly on a brief history of environmental ethics and its protection against damage. Environmental changes and extreme weather events in plus to species distinction and a growth of diseases are impossible to hide and ought to be impossible to ignore. The health decline associated with various forms of these changes is continuing. It raises crucial issues about environmental justice. PMID:23908724

  20. Natural language Interface for Database-A Brief review

    Directory of Open Access Journals (Sweden)

    Neelu Nihalani

    2011-03-01

    Full Text Available Information is playing an important role in our lives. One of the major sources of information is databases. Databases and database technology are having major impact on the growing use of computers. Almost all IT applications are storing and retrieving information from databases. Retrieving information database requires knowledge of database languages like SQL. The Structured Query Language (SQL norms are been pursued in almost all languages for relational database systems. However, not everybody is able to write SQL queries as they may not be aware of the structure of the database. So this has led to the development of Intelligent Database System ( IDBS . There is an overwhelming need for non-expert users to query relational databases in their natural language instead of working with the values of the attributes. As a result many intelligent natural language interfaces to databases have been developed, which provides flexible options for manipulating queries. The idea of using Natural Language instead of SQL has prompted the development of new type of processing called Natural language Interface to Database. NLIDB is a step towards the development of intelligent database systems (IDBS to enhance the users in performing flexible querying in databases. This paper is an introduction to Intelligent Database System and Natural Language Interface to Databases. Then a brief overview of NLIDB subcomponents is given and then discussion then moves on to NLIDB architectures and various approaches for the development of NLIDB systems.

  1. Problem of Brief Interaction of Liquid and Amorphous Bodies

    Science.gov (United States)

    Simankov, D. S.

    2016-01-01

    The author has proposed a model of brief interaction of liquid and amorphous bodies with boundary conditions of the third kind in the amorphous body without a convective mass flux. Consideration has been given to the thermophysical aspect of formation of the temperature sensation of a biomedical object (BMO) on contact with the liquid body with a different temperature. The procedure of short measurements in the stage of irregular thermal regime (pulse method) was applied to investigation of thermal activity of various anatomical sections of the BMO skin as a function of its temperature. It has been shown experimentally that thermal activity grows with temperature and is within 640-1800 J/(m2·K·s0.5). The total relative error of the method of thermal-activity measurements amounted to ~5%. It has been proposed that analytical calculation of the surface temperature of the BMO on contact be modeled as a combination of the temperatures in liquid and solid media by using the criterion of moisture-content percentage in the BMO.

  2. NASA Tech Briefs, February 2001. Volume 25, No. 2

    Science.gov (United States)

    2001-01-01

    The topics include: 1) Application Briefs; 2) National Design Engineering Show Preview; 3) Marketing Inventions to Increase Income; 4) A Personal-Computer-Based Physiological Training System; 5) Reconfigurable Arrays of Transistors for Evolvable Hardware; 6) Active Tactile Display Device for Reading by a Blind Person; 7) Program Automates Management of IBM VM Computer Systems; 8) System for Monitoring the Environment of a Spacecraft Launch; 9) Measurement of Stresses and Strains in Muscles and Tendons; 10) Optical Measurement of Temperatures in Muscles and Tendons; 11) Small Low-Temperature Thermometer With Nanokelvin Resolution; 12) Heterodyne Interferometer With Phase-Modulated Carrier; 13) Rechargeable Batteries Based on Intercalation in Graphite; 14) Signal Processor for Doppler Measurements in Icing Research; 15) Model Optimizes Drying of Wet Sheets; 16) High-Performance POSS-Modified Polymeric Composites; 17) Model Simulates Semi-Solid Material Processing; 18) Modular Cryogenic Insulation; 19) Passive Venting for Alleviating Helicopter Tail-Boom Loads; 20) Computer Program Predicts Rocket Noise; 21) Process for Polishing Bare Aluminum to High Optical Quality; 22) External Adhesive Pressure-Wall Patch; 23) Java Implementation of Information-Sharing Protocol; 24) Electronic Bulletin Board Publishes Schedules in Real Time; 25) Apparatus Would Extract Water From the Martian Atmosphere; 26) Review of Research on Supercritical vs Subcritical Fluids; 27) Hybrid Regenerative Water-Recycling System; 28) Study of Fusion-Driven Plasma Thruster With Magnetic Nozzle; 29) Liquid/Vapor-Hydrazine Thruster Would Produce Small Impulses; and 30) Thruster Based on Sublimation of Solid Hydrazine

  3. Megacities and climate change – A brief overview

    International Nuclear Information System (INIS)

    Cities have developed into the hotspots of human economic activity. From the appearance of the first cities in the Neolithic to 21st century metropolis their impact on the environment has always been apparent. With more people living in cities than in rural environments now it becomes crucial to understand these environmental impacts. With the immergence of megacities in the 20th century and their continued growth in both, population and economic power, the environmental impact has reached the global scale. In this paper we examine megacity impacts on atmospheric composition and climate. We present basic concepts, discuss various definitions of footprints, summarize research on megacity impacts and assess the impact of megacity emissions on air quality and on the climate at the regional to global scale. The intention and ambition of this paper is to give a comprehensive but brief overview of the science with regard to megacities and the environment. - A comprehensive overview of science in relation to megacities and the environment

  4. Briefing book on the energy situation in New England

    Energy Technology Data Exchange (ETDEWEB)

    Brainard, J P; Munson, J S; Palmedo, P F

    1976-10-01

    This briefing book is designed to give a concise overview of the facts of the energy situation in New England and of attitudes within the region towards current energy issues. Many of the central problems of U.S. energy policy are manifested in the region in a magnified form. The region entered the period of energy shortages and increasing prices in an economically declining condition. Energy prices were already high in 1970, 30% higher than the rest of the country; the difference increased to 38% by 1974. With essentially no indigenous energy resources, New England is an energy-importing region. For various reasons it is also more dependent on petroleum than other regions of the country and, at the same time, distant from domestic petroleum-producing regions. The result is that over 60% of the fuels it consumes is imported from abroad. Although the future supply of energy to the region is critically dependent on energy-resource policies, policies related for example to coal and oil shale development, the region's concerns cluster around policies and technologies that are perceived to have a more direct impact on its energy welfare. Thus, energy conservation, solar energy, nuclear power, offshore oil development and, in general, the price of energy to the region are paramount issues of concern and debate. Following the Introductory chapter, these issues are discussed in four additional chapters: The Energy Situation in New England; Regional Energy Issues; Energy-Related Institutions; and State Legislation.

  5. Market brief : The hydrogen and fuel cell market in Denmark

    International Nuclear Information System (INIS)

    This report presents an overview of the hydrogen and fuel cell market in Denmark, a global leader in this domain. The main focus of the hydrogen and fuel cell industry in Denmark is on the development of proton exchange membrane fuel cells, solid oxide fuel cells, and stationary applications for fuel cells. The industry is currently in the research and development phase, but commercialization is expected within the coming years. The wind industry in Denmark also intends to produce hydrogen from wind energy. This market brief describes the potential for Canadian suppliers to enter into joint ventures to establish local production facilities in Denmark and to transfer technology expertise. It describes the key factors shaping market growth and opportunities with actual and planned projects. The competitive environment was also discussed with reference to local capabilities, international competition, the Canadian position, and a competitive advantage through Canadian government policies and initiatives. A list of selected Canadian federal funding programs for the hydrogen and fuel cell industry was included. 27 refs., 2 tabs., 1 appendix

  6. Brief dynamic psychotherapy in a case of obsessive compulsive disorder.

    Science.gov (United States)

    Vyjayanthi, S

    2014-07-01

    A 57 years old married, retired official of Indian Railway service presented with two months complaints of recurrent fears of circulation of a duplicate CD of one of his presentations in an international conference, recurrent thoughts that the years of winning medals during his tenure in Indian Railways service were misrepresented in the records as early years. He recognized these fears as irrational, intrusive causing irritability and extreme anxiety, as he felt an urge to go and check the records, and feared it would cause humiliation. A diagnosis of obsessive compulsive disorder predominantly obsessions were made. Patient refused medication and a keen interest to receive insight. Patient had strong ego functions, stable heterosexual partnership, was open to interpretations and therapeutic contract of ten sessions of David Malan's school of brief dynamic therapy was initiated. Unconscious therapeutic alliance dominated over resistance. Displacement, isolation of affect and undoing were the neurotic defenses interpreted by the therapist. Therapeutic focus was relief of obsessions occurred by 9(th) session and therapy was successfully terminated. PMID:25035560

  7. Katsura Imperial Villa: A Brief Descriptive Bibliography, with Illustrations

    Directory of Open Access Journals (Sweden)

    Dana Buntrock

    2012-06-01

    Full Text Available There are three imperial residences in Kyoto: Gosho (京都御所, rebuilt in 1855 and used for formal affairs even today; Shūgakuin (修学院離宮, a summer retreat on mountain slopes built in the mid-seventeenth century; and Katsura Imperial Retreat (桂離宮, slightly older than Shūgakuin. Upon the death of the Hachijō imperial line in 1881, Katsura came into the hands of the reigning household; shortly afterward, the Imperial Household Ministry was formed and took responsibility for the care of such sites. Sometimes grouped with the other residences, Nijō Palace was originally built not for the imperial household but for the warriors who effectively ruled Japan from the seventeenth to the middle of the nineteenth century; today, it too is managed by the Imperial Household Agency (the scope and name of the Imperial Household Ministry having changed at the end of World War II. Of these four, Katsura, with its extensive grounds and esteemed teahouses in addition to a large, shoin-style residence, is best known of all, used both at home and abroad to illustrate arguments about architecture and national tradition. Yet even so, much remains to be said about the complex, as demonstrated by this brief descriptive bibliography.

  8. Performance Parameters and Characterizations of Nanocrystals: A Brief Review

    Directory of Open Access Journals (Sweden)

    Manasi M. Chogale

    2016-08-01

    Full Text Available Poor bioavailability of drugs associated with their poor solubility limits the clinical effectiveness of almost 40% of the newly discovered drug moieties. Low solubility, coupled with a high log p value, high melting point and high dose necessitates exploration of alternative formulation strategies for such drugs. One such novel approach is formulation of the drugs as “Nanocrystals”. Nanocrystals are primarily comprised of drug and surfactants/stabilizers and are manufactured by “top-down” or “bottom-up” methods. Nanocrystals aid the clinical efficacy of drugs by various means such as enhancement of bioavailability, lowering of dose requirement, and facilitating sustained release of the drug. This effect is dependent on the various characteristics of nanocrystals (particle size, saturation solubility, dissolution velocity, which have an impact on the improved performance of the nanocrystals. Various sophisticated techniques have been developed to evaluate these characteristics. This article describes in detail the various characterization techniques along with a brief review of the significance of the various parameters on the performance of nanocrystals.

  9. Brief behavioral treatment for patients with treatment-resistant insomnia

    Science.gov (United States)

    Wang, Jihui; Wei, Qinling; Wu, Xiaoli; Zhong, Zhiyong; Li, Guanying

    2016-01-01

    Objective To evaluate the efficacy of brief behavioral treatment for insomnia (BBTI) in treating patients with treatment-resistant insomnia. Methods Seventy-nine adults with treatment-resistant insomnia were randomly assigned to receive either individualized BBTI (delivered in two in-person sessions and two telephone “booster” sessions, n=40) or sleep hygiene education (n=39). The primary outcome was subjective (sleep diary) measures of self-report symptoms and questionnaire measures of Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI), Epworth sleeping scale (ESS), and dysfunctional beliefs and attitudes about sleep scale (DBAS). Results The repeated-measures analysis of variance showed significant time effects between pretreatment and posttreatment in the scale ratings of PSQI, ESS, DBAS, ISI, sleep latency (SL), time in bed (TIB), sleep efficiency (SE), and wake after sleep onset (WASO) in both groups and group × time interaction (FPSQI =3.893, FESS =4.500, FDBAS =5.530, FISI =15.070, FSL =8.909, FTIB =7.895, FSE =2.926, and FWASO =2.595). The results indicated significant differences between BBTI and sleep hygiene in change scores of PSQI, ESS, DBAS, ISI, SL, TIB, SE, and WASO. Effect sizes were moderate to large. Conclusion BBTI is a simple and efficacious intervention for chronic insomnia in adults. PMID:27536119

  10. A brief simulation intervention increasing basic science and clinical knowledge

    Science.gov (United States)

    Sheakley, Maria L.; Gilbert, Gregory E.; Leighton, Kim; Hall, Maureen; Callender, Diana; Pederson, David

    2016-01-01

    Background The United States Medical Licensing Examination (USMLE) is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (nl=515) and the intervention group received lecture plus a simulation exercise (nl+s=1,066). Assessment included summative exam questions (n=4) that were scored as pass/fail (≥75%). USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003). Discussion Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum. PMID:27060102

  11. A brief simulation intervention increasing basic science and clinical knowledge

    Directory of Open Access Journals (Sweden)

    Maria L. Sheakley

    2016-04-01

    Full Text Available Background: The United States Medical Licensing Examination (USMLE is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose: To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods: This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (n l=515 and the intervention group received lecture plus a simulation exercise (nl+s=1,066. Assessment included summative exam questions (n=4 that were scored as pass/fail (≥75%. USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results: Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003. Discussion: Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum.

  12. Briefing Book for the Zeuthen Workshop, v.1

    CERN Document Server

    CERN. Geneva. Council Strategy Group; Aleksan, Roy; Bertolucci, Sergio; Blondel, A; Cavalli-Sforza, M; Heuer, R D; Linde, Frank L; Mangano, Michelangelo L; Peach, Kenneth J; Rondio, Ewa; Webber, Bryan R; Allanach, Benjamin C; Butterworth, J; Cervera-Villanueva, Anselmo; Davidson, J; De Naurois, Mathieu; Desch, Klaus; Egede, U; Giudice, Gian Francesco; Glover, N; Höcker, A; Huber, P; Jungmann, Klaus; Lombardi, A; Mezzetto, Mauro; Ollitrault, Jean Yves; Onderwater, Gerco; Palanque-Delabrouille, Nathalie; Polosa, Antonio; Raimondi, Pantaleo; Weiglein, Georg; Womersley, John William; Landua, Rolf; Le Goff, J M; Wurr, K

    2006-01-01

    On Jun 18th 2004, the CERN Council, upon the initiative of its President, Prof. Enzo Iarocci, established an ad hoc scientific advisory group (the Strategy Group), to produce a draft strategy for European particle physics, which is to be considered by a special meeting of the CERN Council, to be held in Lisbon on Jul 14th 2006. There are three volumes to the Briefing Book. This first volume contains an introductory essay on particle physics, a summary of the issues discussed at the Open Symposium, and discussions of the other themes that the Strategy should address. The introductory essay on particle physics and the other themes were commissioned by the Preparatory Group. The summary of the issues discussed in the Symposium was prepared by the chairs of the sessions, the session speakers and the scientific secretaries. We acknowledge that this has been a difficult task, again on a very tight timescale, and we would like to thank all of those who have contributed to this volume.

  13. Biological restoration in pediatric dentistry: a brief insight.

    Science.gov (United States)

    Md, Indira; Singh Dhull, Kanika; Nandlal, B; Kumar Ps, Praveen; Singh Dhull, Rachita

    2014-01-01

    Dental caries is the most prevalent disease in humans, especially during early childhood. The restoration of such an extensive carious lesion should be done properly to reestablish their anatomy and hence their masticatory, phonetic, esthetic and space-maintainer functions in the dental arches. The consequences of premature loss of primary teeth are well known, namely the loss of vertical dimension of occlusion, tongue thrusting and mouth breathing habits, which can be the sources of future malocclusion. Satisfactory restoration of these teeth, improving esthetics, along with the management of space and function has always been a challenge for pediatric dentist. An ever increasing demand for esthetics has led to innovation and development of newer treatment modalities for these problems. In an attempt to widen the treatment options as biologically and conservatively as possible, tooth structure is used as a restorative material to rehabilitate severely destroyed tooth crowns. This technique consists of bonding sterile dental fragments, obtained either from the patient or from a tooth bank, to the teeth. Such a technique was termed as 'biological restoration'. This article aims at reviewing the evolution, techniques and outcome of such biological restorations. How to cite this article: MD Indira, Dhull KS, Nandlal B, Kumar PSP, Dhull RS. Biological Restoration in Pediatric Dentistry: A Brief Insight. Int J Clin Pediatr Dent 2014;7(3):197-201.

  14. Brief dynamic psychotherapy in a case of obsessive compulsive disorder

    Directory of Open Access Journals (Sweden)

    S Vyjayanthi

    2014-01-01

    Full Text Available A 57 years old married , retired official of Indian Railway service presented with two months complaints of recurrent fears of circulation of a duplicate CD of one of his presentations in an international conference , recurrent thoughts that the years of winning medals during his tenure in Indian Railways service were misrepresented in the records as early years. He recognized these fears as irrational, intrusive causing irritability and extreme anxiety, as he felt an urge to go and check the records, and feared it would cause humiliation. A diagnosis of obsessive compulsive disorder predominantly obsessions were made. Patient refused medication and a keen interest to receive insight. Patient had strong ego functions, stable heterosexual partnership, was open to interpretations and therapeutic contract of ten sessions of David Malan′s school of brief dynamic therapy was initiated. Unconscious therapeutic alliance dominated over resistance. Displacement, isolation of affect and undoing were the neurotic defenses interpreted by the therapist. Therapeutic focus was relief of obsessions occurred by 9 th session and therapy was successfully terminated.

  15. Brief guided imagery and body scanning interventions reduce food cravings.

    Science.gov (United States)

    Hamilton, Jonathan; Fawson, Sophie; May, Jon; Andrade, Jackie; Kavanagh, David J

    2013-12-01

    Elaborated Intrusion (EI) Theory proposes that cravings occur when involuntary thoughts about food are elaborated; a key part of elaboration is affectively-charged imagery. Craving can be weakened by working memory tasks that block imagery. EI Theory predicts that cravings should also be reduced by preventing involuntary thoughts being elaborated in the first place. Research has found that imagery techniques such as body scanning and guided imagery can reduce the occurrence of food thoughts. This study tested the prediction that these techniques also reduce craving. We asked participants to abstain from food overnight, and then to carry out 10 min of body scanning, guided imagery, or a control mind wandering task. They rated their craving at 10 points during the task on a single item measure, and before and after the task using the Craving Experience Questionnaire. While craving rose during the task for the mind wandering group, neither the guided imagery nor body scanning group showed an increase. These effects were not detected by the CEQ, suggesting that they are only present during the competing task. As they require no devices or materials and are unobtrusive, brief guided imagery strategies might form useful components of weight loss programmes that attempt to address cravings. PMID:23962401

  16. Tissue engineering in periodontal regeneration: A brief review

    Directory of Open Access Journals (Sweden)

    Sarita Dabra

    2012-01-01

    Full Text Available Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today′s medicine. Regeneration of periodontal tissue is perhaps one of the most complex process to occur in the body. Langer and colleagues proposed tissue engineering as a possible technique for regenerating the lost periodontal tissues. Tissue engineering is a multidisciplinary field, which involves the application of the principles and methods of engineering and life sciences to help in the development of biological substitutes to restore, maintain or improve the function of damaged tissues and organs. A Google/Medline search was conducted and relevant literature evaluating the potential role of the tissue engineering in periodontal regeneration, which included histological studies and controlled clinical trials, was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal regeneration were included. The available literature was analyzed and compiled. The analysis indicate tissue engineering to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. The purpose behind writing this brief review has been to integrate the evidence of research related to tissue engineering so as to implement them in our daily practice.

  17. FISHING IN SINALOA: BRIEF HISTORY AND SEARCH OF EPISTEME

    Directory of Open Access Journals (Sweden)

    Ramón Enrique Morán-Angulo

    2015-01-01

    Full Text Available This paper reports from bibliographic woven into three sections: a brief history of the prehispanic fishing, where the encounter between the indigenous communities of the State of Sinaloa and species that supported the incursion of primitive society in the various ecosystems are described water that make up the vast and varied territory of Sinaloa, where fishing is born as a function of interaction between society and nature through a deep empirical knowledge and a handmade primitive instrumentality that positions in the ecosystem within the flows of matter and energy. The importance of the species used for food fishing, religious symbolism and knowledge acquired and transmitted is denoted by the fishing process. In the second section the economic and social importance of fishing is contextualized, highlighting the current situation based on official information from the volumes recorded catch, species of economic importance and an account of the public policy process becomes mandataron fisheries, identifying transcendent moments on the national fisheries police and the current problem by going through today. Finally the episteme that addresses human resources training and scientific research supporting the fishing process Sinaloa taking the experience in developing the curriculum innovation plan of the Faculty of Marine Science in 2007 is discussed.

  18. The Human Neonatal Gut Microbiome: A Brief Review

    Directory of Open Access Journals (Sweden)

    Emily C. Gritz

    2015-03-01

    Full Text Available The field of genomics has expanded into subspecialties such as metagenomics over the course of the last decade and a half. The development of massively parallel sequencing capabilities has allowed for increasingly detailed study of the genome of the human microbiome, the microbial super organ that resides symbiotically within the mucosal tissues and integumentary system of the human host. The gut microbiome, and particularly the study of its origins in neonates, have become subtopics of great interest within the field of genomics. This brief review seeks to summarize recent literature regarding the origins and establishment of the neonatal gut microbiome, beginning in utero, and how it is affected by neonatal nutritional status (breastfed versus formula fed and gestational age (term versus preterm. We also explore the role of dysbiosis, a perturbation within the fragile ecosystem of the microbiome, and its role in the origin of select pathologic states, specifically, obesity and necrotizing enterocolitis in preterm infants. We discuss the evidence supporting enteral pre- and probiotic supplementation of commensal organisms such as Bifidobacterium and Lactobacillus in the neonatal period, and their role in the prevention and amelioration of necrotizing enterocolitis in premature infants. Finally, we review directions to consider for further research to promote human health within this field.

  19. Schizotypal Personality Questionnaire-Brief Revised: psychometric replication and extension.

    Science.gov (United States)

    Callaway, Dallas A; Cohen, Alex S; Matthews, Russell A; Dinzeo, Thomas

    2014-01-01

    The psychometric screening and detection of schizotypy through the use of concise self-report assessment instruments such as the Schizotypal Personality Questionnaire-Brief Revised (SPQ-BR; Cohen, Matthews, Najolia, & Brown, 2010) enables an expeditious identification of individuals at putatively elevated risk to develop schizophrenia-spectrum disorders. Using 2 large, culturally diverse, independent samples, this study expanded the psychometric evaluation of this instrument by presenting a series of confirmatory factor analyses; reviewing internal consistency reliabilities; and evaluating the construct validity of the scale by way of examining group differences in SPQ-BR scores between individuals with and without self-reported family histories of schizophrenia. The results indicate a 2-tier factor solution of the measure and indicate strong internal reliability for the scale. Findings regarding construct validity of the SPQ-BR are more variable with the Cognitive-Perceptual Deficits superordinate factor receiving the strongest evidentiary support. Limitations of this study and directions for future research are discussed.

  20. Texas State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Texas State Briefing Book is one of a series of state briefing books on low-level radioactivee waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Texas. The profile is the result of a survey of NRC licensees in Texas. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Texas.

  1. Massachusetts State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-03-12

    The Massachusetts State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Massachusetts. The profile is the result of a survey of NRC licensees in Massachusetts. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Massachusetts.

  2. Tennessee State Briefing Book for low-level radioactive-waste management

    International Nuclear Information System (INIS)

    The Tennessee State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal Agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Tennessee. The profile is the result of a survey of NRC licensees in Tennessee. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Tennessee

  3. Mississippi State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Mississippi State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state an federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Mississippi. The profile is the result of a survey of NRC licensees in Mississippi. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Mississippi

  4. Oklahoma State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Oklahoma State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Oklahoma. The profile is the result of a survey of NRC licensees in Oklahoma. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Oklahoma

  5. Georgia State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Georgia State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. This report contains a profile of low-level radioactive waste generators in Georgia. The profile is the result of a survey of NRC licensees in Georgia. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Georgia

  6. Virginia State Briefing Book for low-level radioactive-waste management

    International Nuclear Information System (INIS)

    The Virginia State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Virginia. The profile is the result of a survey of NRC licensees in Virginia. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Virginia

  7. Oklahoma State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Oklahoma State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Oklahoma. The profile is the result of a survey of NRC licensees in Oklahoma. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal cmmunications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Oklahoma

  8. Ohio State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Ohio State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Ohio. The profile is the result of a survey of NRC licensees in Ohio. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Ohio

  9. Kansas State Briefing Book on low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Kansas State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Kansas. The profile is the result of a survey of radioactive material licensees in Kansas. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Kansas

  10. Wyoming State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Wyoming State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Wyoming. The profile is the result of a survey of NRC licensees in Wyoming. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Wyoming.

  11. Rhode Island State Briefing Book on low-level radioactive-waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    The Rhode Island State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Rhode Island. The profile is the result of a survey of radioactive material licensees in Rhode Island. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Rhode Island.

  12. Utah State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    The Utah State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Utah. The profile is the result of a survey of NRC licensees in Utah. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Utah.

  13. Maine State Briefing Book on low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Maine State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Maine. The profile is the result of a survey of radioactive material licensees in Maine. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested partices including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant goverment agencies and activities, all of which may impact management practices in Maine.

  14. Tennessee State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Tennessee State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Tennessee. The profile is the result of a survey of NRC licensees in Tennessee. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Tennessee.

  15. Kentucky State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The Kentucky State Briefing Book is one of a series of State briefing books on low-level radioactive waste management practices. It has been prepared to assist State and Federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Kentucky. The profile is the result of a survey of NRC licensees in Kentucky. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Kentucky.

  16. Brief description of research papers accepted for publication during 1979. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Nash, D.B

    1980-06-16

    Brief descriptions of research papers in radiobiology, biochemistry, metabolism, and biophysics published during 1979 are presented. The research was conducted by investigators in the Dept. of Radiation Biology and Biophysics. (ACR)

  17. Pennsylvania State Briefing Book for low-level radioactive waste management

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    The Pennsylvania State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Pennsylvania. The profile is the result of a survey of NRC licensees in Pennsylvania. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Pennsylvania.

  18. Hawaii State briefing book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Hawaii State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Hawaii. The profile is the result of a survey of NRC licensees in Hawaii. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Hawaii

  19. Connecticut State Briefing Book for low-level radioactive-waste management

    International Nuclear Information System (INIS)

    The Connecticut State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Connecticut. The profile is the result of a survey of Nuclear Regulatory Commission licensees in Connecticut. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may affect waste management practices in Connecticut

  20. Arkansas State Briefing Book for low-level radioactive waste management

    International Nuclear Information System (INIS)

    The Arkansas State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. This report contains a profile of low-level radioactive waste generators in Arkansas. The profile is the result of a survey of NRC licensees in Arkansas. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Arkansas