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Sample records for avaliacao dos tumores

  1. Magnetic resonance imaging textural evaluation of posterior cranial fossa tumors in childhood; Avaliacao textural por ressonancia magnetica dos tumores da fossa posterior em criancas

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    Santos, Joelson Alves dos; Costa, Maria Olivia Rodrigues da; Otaduy, Maria Concepcion Garcia; Lacerda, Maria Teresa Carvalho de; Leite, Claudia da Costa [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Dept. de Radiologia]. E-mail: joelson_alves@ig.com.br; Matsushita, Hamilton [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Dept. de Neurologia

    2004-08-01

    Objective: To distinguish healthy from pathological tissues in pediatric patients with posterior cranial fossa tumors using calculated textural parameters from magnetic resonance images. Materials And Methods: We evaluated 14 pediatric patients with posterior cranial fossa tumors using the software MaZda to define the texture parameters in selected regions of interest representing healthy and pathological tissues based on T2-weighted magnetic resonance images. Results: There was a statistically significant difference between normal and tumoral tissues as well as between supposedly normal tissues adjacent and distant from the tumoral lesion. Conclusion: Magnetic resonance textural evaluation is an useful tool for determining differences among various tissues, including tissues that appear apparently normal on visual analysis. (author)

  2. Computed tomography evaluation of mast cell tumours; Avaliacao por tomografia computadorizada dos mastocitomas

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    Lorigados, Carla Aparecida Batista; Matera, Julia Maria; Macedo, Thais; Pinto, Ana Carolina Brandao Fonseca, E-mail: clorigados@usp.br [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia. Dept. de Cirurgia

    2012-07-01

    The mast cell tumours are common tumours of the canine skin. Computed tomography (CT) has assumed an important role in tumours evaluation and staging. The aim of this study was to evaluate the role of CT as a method of assessing characteristics of mast cell tumors. Ten dogs with mast cell tumor were evaluated. CT was performed before and after the intravenous injection of hydro soluble ionic iodine. Attenuation, contrast enhancement, cleavage with adjacent tissues and the unidimensional measurement of each lesion was determined in it maximum diameter, in transversal plane. Concerning the attenuation characteristic, 50% were homogeneous and 50% heterogeneous. The contrast enhancement was homogeneous in 50% of cases, heterogeneous in 40% and peripheral in 10%. Fifty percent of the tumours showed loss of plane of cleavage and 30% partial loss. This information can help in directing the patients that will be undergoing chemotherapy or surgery. (author)

  3. Fatores prognósticos no tratamento dos tumores intramedulares

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    Koerbel Andrei

    2002-01-01

    Full Text Available Entre 1993 e 1999, foram analisados 35 pacientes submetidos a microcirurgia para remoção de tumor intramedular nos Serviços de Neurocirurgia do Hospital Nossa Senhora das Graças e do Hospital de Clínicas de Curitiba - PR. A população foi composta por 68,6% de pacientes do sexo masculino; a média de idade era de 32,9 anos. A localização tumoral mais frequente foi torácica em 40% dos casos, seguida pela região cervical e cervicotorácica em 25,7%. Ao exame neurológico realizado entre 6 a 12 meses do pós-operatório, 42,9% dos pacientes demonstraram melhora, 34,3% permaneceram estáveis e 22,9% dos casos apresentaram piora. A ressecção foi total em 57,2% dos casos e subtotal em 37,1%. Em 5,7% dos pacientes, foi realizada apenas biópsia para diagnóstico. O grau de ressecção completa foi maior nos ependimomas (13 de 17 casos e menor nos astrocitomas (5 de 12 casos. Entretanto, o grau de ressecção e o tipo histológico não interferiram na morbidade pós-operatória. Fatores como sexo, idade e tamanho do tumor também não demonstraram importância na evolução após a cirurgia. A localização torácica do tumor foi associada a maior morbidade cirúrgica (p=0,021.

  4. Current diagnostic approach of bone tumors in childhood; Abordagem diagnostica atual dos tumores osseos na infancia

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    Torre, Marcia Barbosa; Scatigno Neto, Andre [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Hospital das Clinicas

    1995-09-01

    The authors analyze the magnetic resonance imaging (MRI) as the imaging modality of choice for evaluation of patients with bone tumors or soft tissue tumors. The advent of such a sensitive imaging modality is fortuitous and coincides with a recent change in the therapeutic approach to primary bone tumors. MRI is extremely valuable in monitoring the tumor response to the initial chemotherapy and is accurate defining the margins of tumor, facilitating planning of limb salvage surgical procedures. (author). 5 refs., 8 figs.

  5. Evaluation of effects of ionizing radiation on materials used in dental restorations;Avaliacao dos efeitos da radiacao ionizante em materiais utilizados em restauracoes dentarias

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    Maio, Mireia Florencio

    2009-07-01

    This work consisted of quantitative studies of the effects caused by ionizing radiation on materials used in dental restorations (Titanium, Amalgam, Resin Composite and Glass Ionomer) aiming the deleterious effects of radiotherapy when patients with tumors in head and neck, arising when the teeth are restored within in the field of radiation. Samples were submitted to X-ray beams of 6 MV from a linear accelerator, VARIAN 2100C model. The samples were analyzed by X-ray fluorescence techniques to compare the chemical composition before and after the irradiation. The sample were submitted to Geiger-Mueller detectors and the ionization chambers in order to verify any residual radiation in the samples. The samples were also analyzed by gamma spectrometry by a Germanium detector. These tests were performed to determine small changes in the composition in the samples due to the radiation interaction. The results of this study may encourage the development of new research for alternative materials in dental restorations that can contribute to improve the quality of life of those patients with tumors of the mouth. (author)

  6. Magnetic resonance imaging in the evaluation of standard radiotherapy field borders in patients with uterine cervix cancer;Ressonancia magnetica para avaliacao dos limites dos campos classicos de radioterapia em pacientes portadoras de neoplasia maligna de colo uterino

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    Freire, Geison Moreira; Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo, E-mail: segreto.dmed@epm.b [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Unit of Radioterapy; Ribalta, Julisa Chamorro Lascasas [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Dept. de Gynecology

    2010-05-15

    Objective: to evaluate, by means of magnetic resonance imaging, the standardized field borders in radiotherapy for malignant neoplasm of uterine cervix, and to determine the role of this method in the reduction of possible planning errors related to the conventional technique. Materials and methods: magnetic resonance imaging studies for planning of treatment of 51 patients with uterine cervix cancer were retrospectively analyzed. The parameters assessed were the anterior and posterior field borders on sagittal section. Results: The anterior field border was inappropriate in 20 (39.2%) patients and geographic miss was observed in 37.3% of cases in the posterior border. The inappropriateness of both field borders did not correlate with clinical parameters such as patients' age, tumor staging, histological type and degree. Conclusion: the evaluation of standardized field borders with the use of magnetic resonance imaging has demonstrated high indices of inappropriateness of the lateral field borders, as well as the relevant role of magnetic resonance imaging in the radiotherapy planning for patients with uterine cervix cancer with a view to reduce the occurrence of geographic miss of the target volume. (author)

  7. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas

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    Zuccari D.A.P.C.; Santana A.E.; Rocha N.S.

    2002-01-01

    Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transform...

  8. Imaging diagnosis of nasopharyngeal tumors; Diagnostico por imagem dos tumores da nasofaringe

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    Yamashiro, Ilka; Souza, Ricardo Pires de [Hospital Heliopolis, Sao Paulo, SP (Brazil). Servico de Radiologia. Diagnostico por Imagem]. E-mail: ilkay@terra.com.br

    2007-01-15

    The nasopharynx is located in the upper aero digestive tract. Its roof is formed by the basisphenoid, basiocciput and the anterior aspect of the first two cervical vertebrae, in front of the clivus. The lateral walls are formed by the margins of the superior constrictor muscle and the pharyngobasilar fascia, pharyngeal recess, torus tubarius and pharyngeal opening of auditory tube. The inferior margin of the nasopharynx is a horizontal plane passing through the hard palate and palatopharyngeal muscle. Anteriorly, it is in direct continuity with the nasal cavity through the posterior choanae. It is approximately 2.0 cm in anteroposterior diameter and about 4.0 cm in craniocaudal extent. Squamous cell carcinoma accounts for about 70% to 98% of nasopharyngeal malignant lesions found in adults. This tumor presents a high incidence in Asians, most frequently in men, and is the third most frequent cancer in women. The clinical presentation of this disease depends on the size and site of the lesion, with small-sized lesions being asymptomatic. Computed tomography and magnetic resonance imaging play essential and complementary roles in the staging and treatment of patients with nasopharyngeal cancer. (author)

  9. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas

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    Zuccari D.A.P.C.

    2002-01-01

    Full Text Available Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transformação celular maligna. A alfa-actina e a vimentina mostraram-se eficientes na marcação de células mioepiteliais. A alfa-actina diminuiu a marcação na metaplasia óssea ou cartilaginosa contrariamente à vimentina cuja marcação foi aumentada. Os resultados permitem melhor entendimento da classificação dos tumores mamários de cadelas com a utilização de anticorpos monoclonais como marcadores do citoesqueleto, que se mostraram eficientes nessa caracterização.

  10. Diagnosis and evaluation of surveying examination by intracranial tumor in dogs CT; Diagnostico e avaliacao topografica de neoplasias intracranianas pelo exame de TC em caes

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    Romaldini, Andre Fonseca; Santos, Debora Rodrigues dos; Oliveira, Juliana Messias; Abreu, Felipe Andrei Suarez; Wallace, Verena; Pacheco, Eduardo Nelson da Silva, E-mail: andreromaldini@gmail.com [Hospital Santa Ines de Sao Paulo, Santana, SP (Brazil)

    2012-07-01

    The use of computed tomography (CT) revolutionized image diagnostic in veterinary medicine and currently can be considered one of the most useful tools for the imaging evaluation of intracranial tumor in dogs. Computed tomography of the brain in small animals allows visualization of intracranial tumor, compression of adjacent structures such as cerebral parenchyma, falx or lateral ventricles, and evaluate secondary hemorrhages and edema. The CT imaging provides essential information to indicate the surgical approach for a possible tumor resection or biopsy, including the correct location and boundaries structures involved, and also can be used to monitor the clinical treatment. However, only histopathological examination is able to confirm the final diagnosis. (author)

  11. O líqüido cefalorraqueano iso diagnóstico dos tumores intracranianos

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    Aloysio Mattos Pimenta

    1954-09-01

    Full Text Available Foi feito um estudo do líqüido cefalorraqueano num material de 180 casos de tumores intracranianos, histològicamente verificados, apreciando-se a possibilidade de sugestões diagnósticas, em relação à sede, natureza e aspectos cirúrgico e clínico. Foi utilizada a via cisternal para a obtenção do líquor, sendo que a punção negativa da cisterna constituiu um elemento de suspeita diagnostica nos tumores da fossa posterior e de indicação de cautela ao médico que a pratica. As vantagens da via cisternal para colheita do liquor foram assinaladas. A pressão inicial foi normal em 35% dos casos, diminuída em 7% e aumentada em 58%. A hipotensão apareceu em 5 hematomas, num total de 14 casos considerados. Não houve grande diferença de freqüência de hipertensão entre tumores infra e supratentoriais. Em relação à natureza do tumor, o glioblastoma e o abscesso - processos de crescimento rápido - tiveram maior tendência a apresentar hipertensão, em relativa oposição àqueles de crescimento lento (astrocitoma e meningeoma. Houve concordância absoluta entre os sinais clínicos de hipertensão - tríade hipertensiva completa - e a hipertensão do líquor. Entretanto, nos casos com tríade incompleta, foram verificadas, freqüentes vêzes, valores normais da pressão e mesmo hipotensão. O quociente raqueano de Ayala, nos casos de líquor hipertenso, evidenciou em grande maioria o tipo tumoral (menor que 5. 0 valor da fórmula QR menor que 5 e QRD maior que 3, não foi comprovado em nosso material. A xantocromia foi dominante nos casos de hematoma. O crescimento rápido pareceu influir mais que a natureza específica no aparecimento da xantocromia. O retículo fibrinoso foi notado em 20 casos, dos quais 2 sem taxa elevada de proteínas, aparecendo com maior freqüência nos casos de abscesso e glioblastoma. O líquor hemorrágico sòmente foi observado nos casos de hematoma. A citologia quantitativa não forneceu dados que

  12. Computed tomography of mast cell tumors in dogs: assessment before and after chemotherapy; Tomografia computadorizada de mastocitomas em caes: avaliacao pre e pos-tratamento quimioterapico

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    Lorigados, Carla A.B.; Matera, Julia Maria; Pinto, Ana Carolina B.C.F.; Macedo, Thais R., E-mail: clorigados@usp.br [Universidade de Sao Paulo (FMVZ/USP), SP (Brazil). Fac. de Medicina Veterinaria e Zootecnia. Dept. de Cirurgia; Coppi, Antonio A.; Ladd, Fernando V.L. [Universidade de Sao Paulo (LSSCA/USP), SP (Brazil). Fac. de Medicina Veterinaria e Zootecnia. Lab. de Estereologia Estocastica e Anatomia Quimica; Souza, Vanessa A.F. de [Faculdades Metropolitanas Unidas (FMU), Sao Paulo, SP (Brazil). Curso de Medicina Veterinaria

    2013-11-15

    Nineteen dogs with mast cell tumors treated with chemotherapy were evaluated by computed tomography (CT). Were evaluated aspects related to contours, attenuation, postcontrast enhancement and presence of cleavage with adjacent structures. The RECIST criteria and volumetric measurement of lesions were performed to assess the response to treatment. The mast cell tumors presented a homogeneous or heterogeneous attenuation, presented more frequently a well delineated and regular contours and moderate enhancement after intravenous administration of the iodinated contrast media. The methods RECIST and volumetric measurements showed an excellent agreement to the classification of therapeutic response, providing a good parameter of the response to treatment. The CT examination proved to be useful in the delimitation of the tumor and an important tool for planning of surgical margins. (author)

  13. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas Expression of intermediate filaments in canine mammary tumors diagnosis

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    D.A.P.C. Zuccari; Santana, A. E.; N.S. Rocha

    2002-01-01

    Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transform...

  14. Preliminary evaluation of the protocol scintigraphy of neuroendocrine tumor with metaiodobenzylguanidine (mIBG) labeled with {sup 123}I; Avaliacao preliminar do protocolo de cintilografia de tumores neuroendocrinos com meta-iodobenzilguanidina (mIBG) marcado com {sup 123}I

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    Oliveira, Danillo M. [Hospital de Urgencia de Sergipe Gov. Joao Alves Filho, Aracaju, SE (Brazil); Mendes, Janaina Dutra Silvestre, E-mail: danillo_90@hotmail.com [Instituto Nacional de Cancer Jose Alencar Gomes da Silva, Rio de Janeiro, RJ (Brazil). Setor de Medicina Nuclear

    2014-04-15

    Neuroendocrine tumors have a property of capturing metaiodobenzylguanidine (mIBG) and because of this is possible to perform scintigraphy for diagnosis marking this molecule with {sup 123}I. However, {sup 123}I has some particularities, such as the release of X-ray low energy, which complicates the measurement of activity by activity meter, moreover emits a significant intensity of high energy gamma radiation, damaging the image quality. The acquisition protocol scintigraphy of neuroendocrine tumor was evaluated and the necessary recommendations for its optimization will be studied to ensure image quality with the least possible expense to the patient. (author)

  15. Análise dos últimos 50 casos de tumor de células gigantes ósseo tratados na unidade de tumores do aparelho locomotor dos Hospitais da Universidade de Coimbra

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    Lemos, António Carlos de Almeida Rodrigues de

    2009-01-01

    Introdução e Objectivo: O tumor de células gigantes ósseo constitui 5% dos tumores ósseos primários, podendo atingir os 20% na Ásia. A sua histologia, clínica e epidemiologia são conhecidas e encontram-se bem retratadas na literatura científica actual. O seu comportamento biológico imprevisível torna-o um desafio na obtenção de bons resultados com a preconização da terapêutica cirúrgica. O objectivo deste estudo foi investigar as características epidemiológicas, distribuição esquelética, méto...

  16. Radiation therapy for glomus tumors of the temporal bone; Tratamento radioterapico dos tumores glomicos do osso temporal

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    Dall' Igna, Celso; Antunes, Marcelo B. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Hospital das Clinicas. Servico de Otorrinolaringologia e Cirurgia da Cabeca e Pescoco; Dall' Igna, Daniela Pernigotti [Parana Univ., Curitiba, PR (Brazil)

    2005-11-15

    The treatment of glomic tumors has been controversial since its first description. It can be done with surgery, radiotherapy or just expectation. Aim: the objective of this paper was to evaluate the effectiveness and complications of radiotherapy.Study Design: clinical with transversal cohort. Material and method: it was made a retrospective review in the charts of the patients with glomus jugular tumors treated with radiotherapy. Disease control was determined by (1) no progression of symptoms or cranial nerve dysfunction or (2) no progression of the lesion in radiological follow-up. It was also evaluated the follow-up period and the sequelae of the treatment. Results: twelve patients were included, 8 of then women. The follow-up period was from 3 to 35 years, with a media of 11,6 years. The main symptoms were: hearing loss, pulsate tinnitus, dizziness and vertigo. The signs were pulsate retrotympanic mass, facial palsy and cofosis. The tumors were staged using Fischs classification. The radiotherapy was performed with linear accelerator with dose ranging from 4500-5500 in 4-6 weeks. In the follow-up period were possible to identify sequelaes like dermatitis, meatal stenosis, cofosis and facial palsy. Discussion: the signs and symptoms were the same found in the medical literature. The type and dosages of the radiotherapy were also the same of others reports. All patients had improvement of the symptoms and only one was not considered as having disease controlled. Complications were, in general, minor complications, with exception of the cofosis and facial palsy. Conclusion: radiotherapy is a viable alternative to treatment of these tumors because their good response and low level of complications. It should be considered specially in advanced tumors where a surgical procedure could bring a high level of morbidity. (author)

  17. The use of dynamic computation systems in the evaluation of the damages caused by oil spill; O uso de sistemas computacionais dinamicos na avaliacao dos danos causados por derrames de petroleo

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    Barbosa, Luiz H.C.; Laurino, Luiz S.; Muelbert, Jose H. [Fundacao Universidade Federal do Rio Grande (FURG), RS (Brazil)

    2004-07-01

    Estuarine areas are zones of great environmental risk characterized as great sensitivity to oil and oil products spills. Traditionally, Geographic Information Systems (GIS) are used to evaluate these possible impacts. However, for some groups of organisms, like plankton, the spatial limitations of GIS become inadequate because their distributions exhibits temporal variability and are associated with dynamic environmental factors. Having this in mind, the development of a specific tool is necessary to supply this need. For the development of this tool, data of fish larvae and eggs (ichthyoplankton) from the Lagoa dos Patos Estuary (RS) were chosen as an initial group for the development of a Plankton Diagnostic System (SIDIPLA). These groups have an accentuated sensitivity to oil spills. This impact could directly affect the environment quality and indirectly the local fishing resource. SIDIPLA is elaborated from data reports covering every estuarine area and graphs are generated containing abundance of the species of fish larvae and eggs from the geographical position, season, temperature and salinity; selected by the user from an Internet page (http://corvina.lei.furg.br/sidipla). Several simulations demonstrated the strength of the system and its easy use. Furthermore this tool can be implemented in different places of the Brazilian coast and different groups of organisms. (author)

  18. Indicação e tratamento dos tumores benignos do fígado Indication and treatment of benign hepatic tumors

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    Júlio Cezar Uili Coelho

    2011-12-01

    Full Text Available INTRODUÇÃO: Os tumores hepáticos benignos ocorrem em 9% da população. A grande maioria dessas neoplasias é diagnosticada em pacientes assintomáticos durante a realização de exames de imagem de rotina. OBJETIVO: Apresentar os principais aspectos das indicações e tratamento dos tumores hepáticos benignos. MÉTODOS: Foi realizada revisão de literatura baseada em pesquisa no PubMed, Bireme e Scielo cruzando os descritores neoplasia hepática, hemangioma, adenoma e hiperplasia nodular focal. Foram selecionados, estudos de técnicas cirúrgicas e acrescentada a experiência dos autores. O hemangioma é o tumor hepático mais comum, sendo identificado entre 5% e 7% das necropsias. É mais comum nas mulheres entre as 3ª e 5ª décadas da vida e pode aumentar de tamanho na gravidez e com a administração de estrogênios. Apesar de não estabelecida, a sua causa está relacionada com os hormônios sexuais. As complicações incluem inflamação, coagulopatia, sangramento e compressão de estruturas vizinhas. Rotura espontânea é excepcional, com somente 35 casos descritos na literatura internacional. O adenoma e a hiperplasia nodular focal predominam no sexo feminino e na faixa etária de 20 a 40 anos. Enquanto o primeiro requer ressecção hepática pelo risco de sangramento e malignização, o segundo deve ter conduta expectante. CONCLUSÕES: Os tumores hepáticos benignos mais comuns são em ordem decrescente de frequência o hemangioma, hiperplasia nodular focal e o adenoma. A diferenciação entre tumores benignos e malignos é geralmente realizada com segurança com base nos dados clínicos e nos exames de imagem. O hemangioma e a hiperplasia nodular focal geralmente tem conduta expectante, enquanto que o adenoma requer ressecção pelo risco de hemorragia e de transformação em carcinoma.BACKGROUND: Benign hepatic tumors occur in 9% of the population. The majority is diagnosed in asymptomatic patients during routine imaging exams

  19. Comparação dos métodos de imagem no diagnóstico dos tumores renais e calcificações nestas neoplasias Comparison of imaging methods for diagnosis of renal tumors and their calcifications

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    Sergio Marrone Ribeiro

    2004-12-01

    Full Text Available OBJETIVO: Tentar estabelecer uma metodologia no diagnóstico e conduta dos pacientes com massas renais sólidas e complexas, comparando os custos e benefícios dos diferentes métodos de diagnóstico por imagem. Procuramos avançar no diagnóstico diferencial entre lesões benignas e malignas, particularmente através da investigação das calcificações tumorais. MÉTODOS: Realizamos um estudo prospectivo em 31 pacientes portadores de massas renais sólidas ou complexas, todos eles submetidos à ultra-sonografia abdominal (US, ultra-sonografia doppler da massa renal (US Dop, tomografia computadorizada (TC e ressonância magnética (RM. RESULTADOS: Encontramos 28 pacientes com massas malignas e três com massas benignas. Entre os 28 pacientes com lesões malignas, 17 mostraram calcificações pela TC; 16 deles calcificações do tipo central e um calcificação do tipo curvilinear periférica pura (casca de ovo. A urografia excretora (UGE mostrou uma taxa de detecção para calcificações significantemente menor que a US e a TC. Massas benignas e malignas apareceram como descrito na literatura, com o US, TC e RM mostrando alta sensibilidade e especificidade no diagnóstico dos tumores renais. A exceção foi na US Dop, onde nós obtivemos menor sensibilidade para a caracterização de fluxo tumoral maligno. CONCLUSÕES: Foi surpreendente verificar que a TC revelou calcificações centrais em 51,6% dos pacientes desta série, todas elas em lesões malignas, quando a literatura refere uma freqüência de calcificações entre 8% e 22% dos carcinomas de células renais, em estudos utilizando radiografias simples do abdômen e UGE. Este achado é de grande importância quando consideramos que estas calcificações ocorrem particularmente em neoplasias malignas. Como resultado da comparação dos diferentes métodos de diagnóstico por imagem, nós propomos uma metodologia para adequada investigação dos tumores renais.BACKGROUND: To establish the

  20. Tumores das células da granulosa dos ovários: estudo de 24 casos Granulosa cell tumors of the ovary: a study of 24 cases

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    Artur Lício Rocha Bezerra

    2004-09-01

    Full Text Available OBJETIVOS: avaliar estadiamento, procedimentos cirúrgicos e evolução dos tumores das células da granulosa (TCG dos ovários, dando ênfase à possibilidade de cirurgia conservadora (ooforectomia unilateral. MÉTODOS: este é um estudo de coorte retrospectivo no qual foram incluídas 24 pacientes com TCG tratadas no período de janeiro de 1994 a janeiro de 2004. Foram analisadas variáveis de interesse, tais como idade da paciente, sintomatologia, tamanho tumoral ao exame físico, estadiamento, modalidades de tratamento (tipos de cirurgia e adjuvância com quimioterapia e/ou radioterapia e prognóstico. As associações entre as variáveis foram avaliadas pelo teste do chi-quadrado e para significância estatística considerou-se p OBJECTIVE: to evaluate staging, surgical procedures and outcome of ovarian granulosa cell tumors (GCT, with emphasis in the possibility of conservative surgery (unilateral ooforectomy. METHODS: this is a retrospective cohort study in which 24 patients treated with GCT during the period of January 1994 to January 2004 were included. Variables of interest such as patient's age, symptoms, tumor size on physical examination, staging, treatment modalities (types of surgery and of adjuvant chemotherapy and/or radiotherapy and prognosis have been analyzed. The chi-square test was used to check the association between variables, and the level of significance was set at p < 0.05, always describing the two-tailed Fisher exact test. RESULTS: the patients' age varied from 30 to 82 (mean 51.7 years old. The most frequently referred symptom was pelvic pain (n = 10; 41.7%. Fourteen patients (58.3% presented clinical stage (CS Ic, 5 (20.8% CS IIIc and 5 (20.8% CS Ia. More advanced clinical stages were significantly associated with palpable pelvic masses (p < 0.04. Endometrial hyperplasias were found in 3 (25% of the 12 hysterectomy specimens. The follow-up period varied from 2 to 114 (mean 42.5 months. Among the 16 (66

  1. Imaging diagnosis of neoplasms of the oropharynx; Diagnostico por imagem dos tumores da orofaringe

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    Souza, Ricardo Pires de [Complexo Hospitalar Heliopolis (HOSPHEL), Sao Paulo, SP (Brazil). Servico de Radiologia; Yamashiro, Ilka; Gonzalez, Fabio Mota; Tornin, Olger; Botelho, Renato Assayag; Paes Junior, Ademar Jose de Oliveira [Complexo Hospitalar Heliopolis (HOSPHEL), Sao Paulo, SP (Brazil)]. E-mail: ilkay@terra.com.br

    2005-04-15

    The oropharynx extends from the base of the tongue (circumvallate papilla) to the upper border of the epiglottis and includes the palatine tonsils, soft palate and their muscles. Horizontal lines passing through the hard palate and hyoid bone constitute the superior and inferior limits, respectively. It is bounded anteriorly by the oral cavity and posteriorly by mucosa at the level of the second and third cervical vertebrae. The lateral walls are formed by two arches: the palatoglossus (anteriorly) and the palatopharyngeal (posteriorly) muscles. Staging of the neoplasms of the oropharynx is based on the size of the tumor and on the involvement of adjacent and distant structures. Therefore, the use of imaging methods, particularly computerized tomography and magnet resonance is essential for the assessment of deep extension of these lesions, including areas of difficult evaluation on clinical examination. (author)

  2. Tumorer

    DEFF Research Database (Denmark)

    Prause, J.U.; Heegaard, S.

    2005-01-01

    oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer......oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer...

  3. Study of crotoxin mechanism of action to mammary carcinomas and evaluation of its potential as a radiopharmaceutical; Estudo do mecanismo de acao da crotoxina em tumores mamarios e avaliacao do seu potenctial radiofarmaceutico

    Energy Technology Data Exchange (ETDEWEB)

    Silveira, Marina Bicalho

    2010-07-01

    Crotoxin, the main component of Crotalus durissus terrificus snake venom, has been studied since 1938. It is a natural polypeptidic complex with pharmacological potential because of its antitumoral properties which has attracted great interest for diagnosis and therapy of oncological diseases. However, Crotoxin mechanism of action and sites of specific interaction on tumor cells are still misunderstood. Breast cancer is the second most frequent type in the world and the most common cancer in women. About 30 to 60% of mammary tumors overexpress epidermal growth factor receptor (EGFR), a transmembrane protein related to cell proliferation. Since literature has reported that Crotoxin antitumoral effect is more potent on cells with EGFR overexpression the objectives of this work were to evaluate Crotoxin cytotoxic effects on mammary tumor cells human breast carcinoma (MCF-7) and Ehrlich tumor cells (murine ascitics carcinoma), and to investigate the specific molecular interaction of Crotoxin on Ehrlich tumor cells. Initially, Crotoxin was radiolabelled with iodine-125 ({sup 125}I-Crotoxin) and iodine-131 ({sup 131}I-Crotoxin). Saturation and competition assay were carried out to characterize Crotoxin in vitro interaction; Crotoxin biodistribution studies and singlephoton emission computed tomography (SPECT) of mice bearing Ehrlich tumor have been evaluated to describe in vivo interaction. Our results showed that Crotoxin presented cytotoxic effect against Ehrlich with DL{sub 50} in vitro (concentration of compound which is lethal for 50% of cells) of about one micromolar, but did not present significant effect against MCF-7. Morphological alterations characteristic of apoptosis suggests programmed cell death. {sup 125}I-Crotoxin interaction with Ehrlich tumor cells was saturable with approximately 70% specificity, and presented K{sub d}=24.98 nmol/L and B{sub max}=16,570 sites/cell for low affinity binding sites and K{sub d}=0.06 nmol/L and B{sub max}=210 sites

  4. Setorectomia posterior direita laparoscópica no tratamento dos tumores hepáticos Laparoscopic right posterior sectioniectomy for treating hepatic tumors

    Directory of Open Access Journals (Sweden)

    Sergio Renato Pais Costa

    2010-12-01

    Full Text Available INTRODUÇÃO: A ressecção de neoplasias no setor posterior direito costuma ser um desafio técnico pela dificuldade de sua abordagem. Adicionalmente, as hepatectomias laparoscópicas tem se tornado alternativa interessante em virtude de muitas vantagens (baixa morbidade, curto tempo de internação, retorno precoce as atividades laborais e bons resultados cosméticos. OBJETIVO: Relatar experiência em doentes submetidos à setorectomia posterior direita laparoscópica por uma única equipe. MÉTODOS: Cinco doentes foram operados entre novembro de 2008 a agosto de 2010. A idade variou de 21 a 63 anos com mediana de 43 anos. Foram quatro mulheres e um homem. A causa das neoplasias foi: adenoma (n=2, hepatocarcinoma (n=1 e metástases (n=2. A lesão foi solitária em três casos (60 %. A média do tamanho das lesões foi 3,3 cm (1,8-5. Foram analisados: tempo cirúrgico, sangramento operatório, morbimortalidade, tempo de internação e tempo de retorno à atividade habitual. RESULTADOS: A média de tempo cirúrgico foi de 160 minutos (90-260. A de sangramento intra-operatório foi de 200 ml (0-500. Nenhum doente foi transfundido. Não houve mortalidade e a morbidade foi nula. A mediana de internação foi de três dias (2-5. A mediana de retorno às atividades cotidianas foi de 12 dias (7-20. A mediana de seguimento foi de 13 meses (1-20. Não houve recidiva de lesão. CONCLUSÃO: A setorectomia posterior direita laparoscópica representa boa opção tática para o tratamento dos tumores hepáticos situados no setor posterior do lobo direito. É opção segura que evita grandes incisões com morbimortalidade. Também apresenta bom resultado cosmético e retorno precoce ao trabalho.BACKGROUND: Resection of neoplasms arising in the posterior right sector is usually a technical challenge due to approach difficulties. Additionally, laparoscopic hepatectomy has become an interesting alternative with several advantages (low morbidity, short hospital

  5. Evaluation of parapharyngeal space by computerized tomography and magnetic resonance. Part 2: tumours and pseudo tumours; O valor da tomografia computadorizada e da ressonancia magnetica na avaliacao do espaco parafaringeo. Parte 2: tumores e pseudotumores

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Ricardo Pires de; Rapoport, Abrao [Hospital Heliopolis, Sao Paulo, SP (Brazil)

    1994-01-01

    The tumors of the parapharyngeal space are a heterogeneous group of lesions not actually originating in the parapharyngeal space itself, fascially defined, but usually in the adjacent spaces, the mucosal pharyngeal space, masticatory space and carotid space. Centrally localized in the supra-hyoid neck, the parapharyngeal space can be used as a diagnostic key in the compartmental localization of these regional lesions, since one observes the pattern of dislocation of the fat content of the space by the lesions at computerized tomography or magnetic resonance. The authors reported 14 cases of parapharyngeal tumors analysed using this criteria, leading to 86% of correct compartmental localization. (author) 155 refs., 13 figs., 2 tabs.

  6. Color Doppler sonography with contrast in the differentiation of ovarian tumors Ultra-sonografia com Doppler colorido e uso de contraste na diferenciação dos tumores ovarianos

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    Eduardo Cardoso Blanco

    2003-01-01

    TODO: Foram estudadas sessenta e duas mulheres (idade média de 49,9 anos com tumores ovarianos, sendo 45 benigos e 17 malignos. Todas foram submetidas a ultra-sonografia transvaginal com Doppler colorido. A pesquisa de fluxo vascular foi realizado em todas as áreas tumorais, assim como a avaliação da impedância através do índice de resistência. RESULTADOS: A localização dos vasos no tumor revelaram uma maior proporção de fluxo vascular interno detectável nos tumores malignos (64% do que nos tumores benignos (22%. Houve entretanto uma considerável sobreposição destes achados. O uso de constrate foi capaz de identificar um grande número de vasos na totalidade dos tumores, mas não melhorou a capacidade do Doppler na diferenciação entre tumores benignos e malignos. Os tumores malignos apresentaram valores mais baixos de índice de resistência.IR do que os benignos, independentemente do uso de contraste. O valor de corte do índice de resistência. que maximizou a sensibilidade e a especificidade do Doppler foi de 0,55. Com este valor foi obtido um aumento na sensibilidade após o uso de contraste, variando de 47% a 82 %, enquanto a especificidade se manteve equivalente. CONCLUSÃO: Embora a injeção de agentes produtores de microbolhas aumentem a sensibilidade do método na diferenciação da natureza do tumor, este valor não se mostrou clinicamente util na avaliação de tumores ovarianos.

  7. Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors; Avaliacao de algumas sequelas bucais pos-radioterapia em pacientes tratados de neoplasias de cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Rubira, Cassia Maria Fischer; Devides, Nadia Juliana; Ubeda, Liliane Torsani; Lauris, Jose Roberto; Rubira-Bullen, Izabel Regina Fischer; Damante, Jose Humberto [University of Sao Paulo, Bauru, SP (Brazil). School of Dentistry. Stomatology Dept.; Bortolucci Junior, Antonio Geraldo [Amaral Carvalho Hospital, Jau, SP (Brazil)]. E-mail: damante@fob.usp.br

    2007-07-01

    The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%), dysphagia (38%), and dysgeusia (30%). In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 ({+-} 0.714). Stimulated salivary flow increased with increasing postradiotherapy time (p < 0.05). The prevalence of mucositis was associated with higher radiation doses (p < 0.05), and the prevalence of atrophic candidiasis was related to a longer post-treatment period (p < 0.05). Two cases of recurrence of the primary tumor were detected during the study. The main effect of radiotherapy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow. (author)

  8. Identification of anti-tumoral effect of a polypeptide isolated from Scorpionfish Scorpaena plumieri venom and assessment of its potential use for tumor diagnosis; Identificacao do efeito antitumoral de um polipeptidio isolado da peconha do peixe-escorpiao Scorpaena plumieri e avaliacao do seu potencial uso no diagnostico de tumores

    Energy Technology Data Exchange (ETDEWEB)

    Soprani, Juliana

    2008-07-01

    Cancer has killed millions of people worldwide. Despite the increasing knowledge about the molecular basis of tumor development, few advances have been reached in clinical therapy and diagnoses, which shows the importance of new drugs development for therapeutic and diagnosis purpose. Venomous creatures have been studied as potential sources of pharmacological agents and physiological tools. A lot of work has been done about biological activity of terrestrial animals, but comparatively less research has been undertaken on venomous marine creature, particularly fish, which means that marine toxins represent a vast and unexplored source of novel molecules with therapeutical potential. In this work, the scorpion fish Scorpaena plumieri crude venom (SPB) and a gelatinolytic protease purified from this venom (SPGP) were evaluated for their applicability for in vivo tumor detection. In vitro results showed that both. SPB and SPGP, possess a powerful antitumor effects on p53-wild-type glioblastoma cells (LD{sub 50}= 3,9 {+-} 0,98{mu}g/mL and 8,00 x 10{sup -12} {+-} 2,94 x 10{sup -12}M, respectively) and Ehrlich ascites carcinoma cells (LD{sub 50}=14,05 {+-} 2,95 {mu}g/mL and 1,22 x 10{sup -11} {+-} 6,56 x 10{sup -12}M, respectively). P53 mutant glioblastoma cells were more resistant to both, SPB and SPGP treatment (LD{sub 50} > 125 {mu}g/mL and LD{sub 50} > 1,39 x 10{sup -9}M, respectively). The morphological changes observed in the cell lines treated with SPB and SPGP, and the data of DAPI staining, indicate that the antitumor effect of these substances occurs via apoptosis. Radioactive probes of SPB ([{sup 99m}Tc] SPB) and SPGP ([{sup 125}I] SPGP) with high specific activity and high radiochemical purity were synthesized. Data of biodistribution studies, performed by intravenous injections in Swiss mice bearing Ehrlich carcinoma cells, showed that SPB has poor uptake in tumor region. On the other hand, SPGP had a substantial uptake in tumor at ali analyzed times

  9. Optimization of methods to assess mitochondrial DNA in archival paraffin-embedded tissues from mammary canine tumors Otimização dos métodos para avaliar o DNA mitocondrial obtido a partir de tumores mamários caninos incluídos em parafina

    Directory of Open Access Journals (Sweden)

    Angélica C. Bertagnolli

    2008-08-01

    Full Text Available In this study we describe the alterations used to extract and amplify mitochondrial desoxyribonucleic acid (DNA from formalin-fixed paraffin-embedded samples of canine mammary tumors. The epithelial and mesenchymal components (chondromyxoid and chondroid of each tumor, as well as the normal mammary gland tissues, were manually microdissected from 19 mixed canine mammary tumors (10 benign mixed tumors and nine carcinomas arising in mixed tumors. DNA was extracted by Invisorb® Spin Tissue Mini Kit, with protocol changes proposed by the manufacturer. A 273-bp fragment was amplified by polymerase chain reaction (PCR and submitted to automatic sequence analysis. The fragment was successfully analyzed in 100% of the samples. However, an additional lysis step, the reduction of volume in buffer solutions and PCR, a higher annealing temperature and an increase in the number of PCR cycles were required. The initial PCR products were diluted and re-amplified in six samples so that they could be successfully analyzed.A presente comunicação descreve as modificações usadas para extrair e amplificar o DNA mitocondrial obtido de amostras de tumores mamários caninos fixados em formol tamponado a 10% e incluídos em parafina. Os componentes epiteliais e mesenquimais (condromixóide e condróide, bem como a mama normal adjacente, foram microdissectados manualmente de 19 tumores mamários (10 tumores mistos benignos e nove carcinomas em tumores mistos. O DNA foi extraído utilizando-se o Invisorb® Spin Tissue Mini Kit com modificações do protocolo proposto pelo fabricante. Um fragmento de 273-pb foi amplificado por reação em cadeia da polimerase (PCR e seqüenciado em seqüenciador automático. O fragmento foi analisado em 100% das amostras, entretanto modificações como lise adicional, redução do volume das soluções de extração e PCR, aumento da temperatura de anelamento e do número de ciclos de amplificação foram necessárias. Em seis

  10. Tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008479 Preliminary study of MR elastography in brain tumors. XU Lei(徐磊), et al.Neurosci Imaging Center, Beijing Tiantan Hosp, Capital Med Univ, Beijing 100050.Chin J Radiol 2008;42(6):605-608. Objective To investigate the potential values of magnetic resonance elastography (MRE) for evaluating the brain tumor consistency in vivo. Methods Fourteen patients with known solid brain tumor (5 male, 9 female; age range: 16-63 years)

  11. Preparation and assessment of [{sup 99m}Tc]technetium aquacarbonyl complexes with 1,2-diaminoethane-N-substituted ligands for tumor detection; Preparo e avaliacao de complexos de [{sup 99m}Tc]tecnecio aquacarbonil com ligantes 1,2-diaminoetano-N-substituidos para deteccao de tumores

    Energy Technology Data Exchange (ETDEWEB)

    Radin, Adriano

    2010-07-01

    Over least 15 years the complex [[{sup 99m}Tc](H{sub 2}0){sub 3}(CO){sub 3}]{sup +} has been used as an intermediary to obtain technetium radiopharmaceuticals for applications in cardiology, neurology and oncology. Two important characteristics of this molecule are: the facility for obtaining that compound from aqueous solutions and the easiness of substituting H{sub 2}O molecules by atoms of other ligand molecules. In this project we prepared new complexes [[{sup 99m}Tc](CMN{sup S001-3})(H{sub 2}O)(CO){sub 3}]{sup +}, where (CMNS001) = N-[(4-methoxy) benzyl]-1,2-diaminoethane, (CMNS003) = N,N'-bis-[(4-methoxy)benzyl]-1,2-diaminoethane, and assessed the uptake of these complexes in murine melanoma cancer cell B16F10 and breast cells MCF-7 and MDA-MD-231, and compared with [[{sup 99m}](MIBI){sub 6}]{sup +} uptake. In vitro uptake for both new technetium complex reached values close to 5%, for all cell lines, whereas the [[{sup 99m}Tc](MIBI){sub 6}]{sup +} uptake was close to 1 %. The assessment of subcellular distribution showed high accumulation of the new complex in the membrane fraction, for MDAMB-231, while for B16F10 accumulation occurred both in membrane and cytoplasm; the concentration of [[{sup 99m}Tc](MIBI){sub 6}]{sup +} was mainly in the cytoplasm portion. Biodistribution study in mice allowed to observe the capture of up to 1.6% of the administered dose per gram of tumor tissue for the complex [[{sup 99m}Tc](CMNS001)(H{sub 2}O)(CO){sub 3}]{sup +}, whereas other organs such as heart, lung and muscle, showed uptake of about 5.6%, 6.4% and 2%, respectively. The complexes in this work showed a high rate of uptake in vitro, but was not reproduced in vivo model, which can be related to low concentration of the complexes inside the cells and reduced vascularity of tumor tissue, with lower intake of complex through the blood system. (author)

  12. Avaliacao neuropsicologica de idosos praticantes de capoeira

    Directory of Open Access Journals (Sweden)

    Diogo Miranda Petry

    2014-01-01

    Full Text Available INTRODUÇÃO: Este estudo procura contribuir com uma relação pouco explorada no meio acadêmico: capoeira, cognição e envelhecimento. Relacionando estudos sobre funções executivas e a capoeira, busca-se investigar a interligação desta arte e as funções executivas. Estas se referem a desempenhos de comportamentos complexos (memória de trabalho, flexibilidade mental, tomada de decisão e a memória léxico-semântica. OBJETIVO: Comparar o desempenho de funções executivas em idosas praticantes de capoeira e idosas não praticantes de exercício físico. MÉTODO: Estudo transversal que coletou as informações de cada participante apenas uma vez. Serão comparados dois grupos: 1 grupo de idosos praticantes de capoeira e 2 idosos que não fazem exercício físico. Para seleção e caracterização dos grupos utilizaram-se: questionário sociodemográfico, aspectos gerais de saúde e escala de hábitos de leitura e escrita, mini-exame de estado mental (MEEM e escala de depressão de Yesavage (GDS-30. Para avaliar o desempenho das funções executivas foi realizado o teste de trilhas e as tarefas de fluência verbal. Para análise estatística dos dados será utilizado o teste de Shapiro-Wilk para normatização dos dados. O teste de t de Student e o teste U de Mann Whitney serão usados para comparar duas médias de amostras independentes. Utilizou-se a improvisação, a ação, a tomada de decisão, o equilíbrio e as noções de espaço, tempo, ritmo, música, e a compreensão do jogo da capoeira como intervenção devido à possível utilização dos processos executivos nessa arte. RESULTADOS: Verificou-se que não houve diferença significativa nos testes realizados. Porém houve superioridade nos testes de fluência verbal e testes de trilha A e B, sendo maior em B no grupo de capoeira do que no grupo controle. CONCLUSÃO: A prática de capoeira tem uma tendência em contribuir para a melhora das funções executivas, embora os

  13. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    OpenAIRE

    Isabella Coimbra Wagner; Murilo José de Barros Guimarães; Lilian Karine Neves da Silva; Francisco Montenegro de Melo; Maria Tereza Cartaxo Muniz

    2007-01-01

    OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA), fragmento da citoqueratina 19 (CYFRA21-1) e antígeno glicosídico associado a tumor 15-3 (CA 15-3) em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi real...

  14. Characterization of the anti tumoral activity of the thiosemicarbazones derived from N(4)-methyl-tolyl-2acetylpyridine And 2-pyridinoformamide and its metal complex: evaluation of the radiopharmaceutical potential; Caracterizacao da atividade antitumoral das tiossemicarbazonas derivadas de N(4)-metil-toluil-2-acetilpiridina e 2-piridinoformamida e seus complexos metalicos: avaliacao do potencial radiofarmaceutico

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Paulo Roberto Ornelas da

    2008-07-01

    Thiosemicarbazones have attracted great pharmacological interest because of their biological properties, such as cytotoxic activity against multiple strains of human tumors. The most studied compounds are pyridine-based because of their resemblance to pyridoxal metabolites that attach to co-enzyme B{sub 6}-dependant enzymes. This work aimed the characterization of the anti tumoral effect of N(4)-methyl-tolyl-2-acetylpyridine and 2-pyridinoformamide-derived thiosemicarbazones and the development of a radiopharmaceutical based on a thiosemicarbazone metal complex for positron emission tomography. In the first phase of this study were synthesized twenty-one thiosemicarbazones, derived from N(4)methyl-2 acetylpyridine and 2-pyridine formamide, as well as their metal complexes (Sn, Ga and Cu). Their cytotoxic potential were evaluated against brain and breast tumor cells in vitro. Our results showed all of them presented powerful cytotoxic and antiproliferative activities against glioblastoma multiform and breast adenocarcinoma at very low concentrations (nanomolar range). Morphological alterations characteristic of apoptosis, such as cell shrinkage, chromatin condensation were observed. Copper chloride was used as control and has presented IC50 at millimolar range suggesting that copper complexation with thiosemicarbazone significantly increases (more than 1 million) the anti tumoral effect of this metal. Due to the potent anti tumoral activity of N(4)-methyl-tolyl-2-acetylpyridine derived thiosemicarbazones and the excellent properties of {sup 64}Cu (T{sub 1/2} = 12.7 hours, {beta}{sup +}, {beta}{sup -}, and EC decay), at the second part for this work it was developed a new imaging agent (radiopharmaceutical) for tumor detection by positron emission tomography (PET). The radiopharmaceuticals were produced in the nuclear reactor TRIGA-IPR-R1 from CDTN, via neutron capture reaction {sup 63}Cu (n,{gamma}) {sup 64}Cu, of the copper complex N(4)-ortho-toluyl-2

  15. Comprobación de la efectividad de dos esquemas terapéuticos en el tratamiento del Tumor de Sticker en perros

    Directory of Open Access Journals (Sweden)

    Ibrain Calero Herrera; Reginald Eustace Thomas, Juan Carlos; Rodríguez Fernández.

    2006-10-01

    Full Text Available RESUMENSe estudiaron 14 perros afectados detumoraciones en los genitales externos.En cada caso se realizó un estudio previodonde se elaboró una historia clínica yposteriormente se le tomaron muestras desangre con y sin anticoagulante para larealización de un hemograma y ladeterminación de las proteínas totales,además se tomó una muestra de tejidotumoral para su estudio histopatológico.Los animales se dividieron en 2 grupos,uno tratado al que se le administró Sulfatode Vincristina a razón 0.025mg/kg de pesocorporal endovenoso con una frecuenciasemanal y un grupo control que fuerontratados quirúrgicamente con ablacióntotal del tumor y su posterior cauterizacióncon el electrocauterio. En todos los casosse confirmó la presencia de Tumor deSticker, la mayor incidencia es a los 6años, el 78.57% de los animales sonhembras, el 14.28% mostraron metástasis,los animales de ambos grupos mostraronanemia, los mejores resultados seobtuvieron con la quimioterapiaobteniéndose la recuperación total de losanimales con 3 ó 4 tratamientos (66.7% y33.3% respectivamente, existió unaligera tendencia a elevarse el Hematocritoy la Hemoglobina y no hubo recidiva,mientras que en el grupo control sepresentó recidiva en el 20% de losanimales. Se concluyó que laquimioterapia es más efectiva en eltratamiento del Tumor de Sticker que elmétodo quirúrgico lográndose unagran efectividad del sulfato de Vincristinasin que repercuta desfavorablementesobre los parámetros hematológicos ysalud de los animales.

  16. Computed tomography in the analysis of calcification patterns in pediatric bone tumors of the hip: a new approach; Tomografia computadorizada na analise dos padroes de calcificacoes nos tumores osseos da bacia em pediatria: nova abordagem

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Gabriel Antonio de; Werlang, Henrique Zambenedetti; Bergoli, Pedro Martins [Hospital Universitario Cassiano Antonio de Morais/Hospital Infantil Nossa Senhora da Gloria, Vitoria, ES (Brazil). Centro de Diagnostico por Imagem]. E-mail: hzwerlang@gmail.com; Frechiani, Madalena; Oliveira, Fernao [Hospital Infantil Nossa Senhora da Gloria, Vitoria, ES (Brazil)

    2006-11-15

    Objective: In the pediatric group, the radiological diagnosis of bone tumors of the hip is difficult and presents some peculiarities, but reviewed literature does not approach this specific problem. The objective of the present study was to investigate the existence of reliable radiological patterns for the differential diagnosis of these tumors. Materials And Methods: Radiological findings of bone tumors of the hip in ten patients in the age range between 8 and 19 years have been reviewed. Results: Bone reaction (sclerosis or lysis), periosteal reaction (lamellar with single or multiple layers, or radial), tumor extent in the bone and level of soft tissues invasion have presented low specificity. Soft tissue calcifications, when considered as a whole, were non-specific. However, when those calcifications with varied shapes and sizes, nearby the affected bone (pattern I) were separated from those, thin and amorphous, away from the bone (pattern II), we have observed that the pattern I was totally non-specific, and the pattern II was found in the three cases of osteosarcoma (100%) and in only one case of Ewing's sarcoma (16.6%). Conclusion: In the present study, pattern II calcifications have shown a 100% sensitivity and 90% specificity for osteosarcoma. However, their importance may be not limited to the radiological diagnosis. Pattern II calcifications indicate probably ideal sites for biopsy. (author)

  17. Inclusão dos sintomas na discriminação entre tumores anexiais benignos e malignos Inclusion of symptoms in the discrimination between benign and malignant adnexal masses

    Directory of Open Access Journals (Sweden)

    Caio Augusto Hartman

    2012-11-01

    Full Text Available OBJETIVO: Avaliar a associação entre sintomas clínicos e malignidade em mulheres com tumores anexiais, submetidas à cirurgia. MÉTODOS: Estudo de corte transversal com coleta prospectiva, no qual foram incluídas 105 mulheres, atendidas em um hospital de ensino do Estado de São Paulo de novembro de 2009 a março de 2011, devido ao tumor anexial e à indicação de laparotomia/laparoscopia. Todas foram submetidas a uma entrevista estruturada sobre a ocorrência de 18 sintomas associados ao câncer de ovário. A entrevista incluiu gravidade, frequência e duração dos sintomas nos 12 meses prévios à primeira consulta. Também foram avaliados os níveis de CA125 e a classificação ultrassonográfica. Foi calculada para cada sintoma a razão de prevalência com intervalo de confiança de 95%. O padrão-ouro foi o resultado do exame anatomopatológico das peças cirúrgicas. RESULTADOS: Das 105 mulheres incluídas, 75 (71,4% apresentaram tumores benignos e 30 (28,6%, malignos. Em mulheres com tumores malignos, os sintomas foram mais frequentes, dentre eles: inchaço abdominal (70%, aumento do volume abdominal (67%, dor pélvica (60%, irregularidade menstrual (60%, empachamento (53%, dor abdominal (50%, dor nas costas (50% e saciedade precoce (50%. As mulheres com tumores benignos apresentaram essencialmente dor pélvica (61%, irregularidade menstrual (61% e inchaço abdominal (47%. Os sintomas significativamente associados com malignidade foram: sensação de inchaço abdominal (RP=2,0; IC95% 1,01 - 3,94, aumento objetivo do volume abdominal (RP=2,16; IC95% 1,12 - 4,16, dor nas costas (RP=1,97; IC95% 1,09 - 3,55, empachamento (RP=2,25; IC95% 1,25 - 4,07, saciedade precoce (RP=2,06; IC95% 1,14 - 3,70, massa abdominal (RP=1,83; IC95% 1,01 - 3,30, dificuldade para deglutir (RP=1,98; IC95% 1,10 - 3,56 e sangramento pós-menopausa (RP=2,91; IC95% 1,55 - 5,44. A presença de dor pélvica, constipação, dispareunia, fadiga, dor abdominal, n

  18. Tumor de células granulares de piel mamaria : Estudio morfológico de dos casos mostrando inmunorreactividad frente a-inhibina

    OpenAIRE

    Vera Sempere, Francisco José; García, Ana; Froufe, Agustín; Corell, Emilia; Ruiz, Francisco; Mayordomo, Fernando

    2003-01-01

    Introducción: El tumor de células granulares (TCG) es una lesión infrecuente en la mama, representando solo el 6-8% de los TCG, comprometiendo a menudo a la piel mamaria. Pacientes y métodos: Se revisa la casuística de TCG mamarios del Hospital Universitario La Fe de Valencia en un período de 19 años, con un total de 8000 especímenes biópsicos mamarios con 2200 diagnósticos de cáncer, realizando de forma retrospectiva un estudio morfológico (óptico, inmunohistoquímico y ultraestructural) a pa...

  19. Tumores neuroectodérmicos primitivos periféricos de localización en el área orocervical: presentación de dos casos clínicos Peripheral primitive neuroectodermal tumors located in orocervical area: presentation of two clinical cases

    Directory of Open Access Journals (Sweden)

    C. Sánchez Acedo

    2010-03-01

    Full Text Available Introducción: Los tumores neuroectodérmicos primitivos (PNET, de primitive neuroectodermal tumors son una familia de neoplasias malignas de células pequeñas y redondas, que derivan de la cresta neural. Se distinguen tres tipos: PNET del sistema nervioso central, PNET del sistema nervioso autónomo y PNET periféricos. Los más frecuentes dentro del grupo de PNET periféricos son el neuroepitelioma periférico y el sarcoma de Ewing, que se consideran la misma neoplasia pero con diferente grado de diferenciación. Casos clínicos: Presentamos dos casos de PNET periféricos, uno de aparición en la región cervical y otro originado en el cóndilo mandibular. Discusión: Los PNET son neoplasias muy raras y altamente agresivas. En todos ellos aparecen células redondas pequeñas poco diferenciadas y una traslocación cromosómica característica del gen EWS. En general se considera que tienen un pronóstico desfavorable. Además, la baja frecuencia de estos tumores, así como la escasez de casos publicados hacen difícil valorar el tratamiento más adecuado.Introduction: Peripheral primitive neuroectodermal tumors (PNET are a family of smallround cell tumors of presumed neuroectodermal origin. This broad family can be subdivided into three major groups: PNET from the central nervous system, PNET from the autonomic nervous system or peripheral PNET. Ewing´s sarcoma and peripheral neuroepitelioma, the two most frequently encountered members of the peripheral PNET family, are considered to represent a spectrum according to the extent of neuroectodermal differentiation, ranging from the least differentiated (Ewing´s sarcoma to the most differentiated (peripheral neuroepithelioma. Case report: We present a patient with a peripheral neuroectodermal tumor located in the neck and another one with a peripheral neuroectodermal tumor of the mandibular condyle. Discussion: Peripheral neuroectodermal tumors are a very rare and aggressive tumors. They

  20. Estudo comparativo dos métodos de ultra-sonografia, tomografia computadorizada e ressonância magnética no estadiamento e invasão das estruturas adjacentes por tumores renais A comparative study of ultrasonography, computed tomography and magnetic resonance imaging in the staging and invasion of adjacent structures by renal tumors

    Directory of Open Access Journals (Sweden)

    S.M. RIBEIRO

    2001-09-01

    Full Text Available OBJETIVO: Comparamos os exames de ultra-som (US, tomografia computadorizada (TC e ressonância magnética (RM no estadiamento dos tumores renais, estudando as diferenças entre estes exames em relação a sua capacidade de detecção de adenomegalias, invasão vascular, metástases intra-abdominais à distância e particularmente invasão dos órgãos adjacentes. MÉTODOS: Foram estudados prospectivamente 31 pacientes portadores de massas renais sólidas ou complexas através dos exames de US, TC e RM. As discordâncias entre os resultados observados foram estudadas através do Teste G de Cochran e Teste de McNemar, além de se calcular a sensibilidade e especificidade de cada método diagnóstico utilizado, considerando-se como "regra de ouro" os achados cirúrgico e anatomopatológico. RESULTADOS: Destes 31 pacientes, 28 eram portadores de massas malignas e três de lesões benignas. Quanto à detecção de adenomegalia, o US mostrou sensibilidade de 63,6%, enquanto a TC e RM tiveram sensibilidade de 90,9%. Em relação à invasão vascular, o US mostrou sensibilidade de 42,8% enquanto que a TC e a RM tiveram a sensibilidade de 85,7%. Em relação à invasão de órgãos adjacentes, a sensibilidade foi respectivamente 28,5% (US, 85,7% (TC e 71,4% (RM. São critérios que sugerem a invasão das estruturas adjacentes: quando estas se encontram envolvidas/englobadas pelo tumor; a extensão do tumor para o seu interior com superfície de contato irregular; alterações na forma, tamanho e densidade da estrutura adjacente. Somente a perda do plano de gordura e o íntimo contato do tumor com a estrutura adjacente não indicam invasão. CONCLUSÕES: Houve diferenças significantes na capacidade de detecção do US em relação à TC e RM. Estas duas últimas não diferiram entre si. Somente em relação às metástases abdominais à distância todos os métodos se mostraram altamente sensíveis e específicos. Além da acurácia dos métodos, tanto

  1. Estudo citofotométrico da expressão dos marcadores tumorais Caspase-3 e Ki-67 no adenocarcinoma gástrico Cytophotometric study of the expression of tumoral markers Caspase-3 and Ki-67 in gastric adenocarcinoma

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    Pedro Manuel Gonzales Cuellar

    2007-06-01

    Full Text Available RACIONAL: A carcinogênese gástrica é processo complexo e depende de fatores genéticos, ambientais e infecciosos. Nos últimos anos, houve grandes avanços nos campos da genética e da biologia molecular, sobre o desenvolvimento dos tumores. Os marcadores tumorais são substâncias ausentes nos tecidos normais e que podem ser identificadas em tecidos com câncer. Através de procedimentos imunoistoquímicos eles podem ser estudados. OBJETIVOS: Descrever a expressão citofotométrica do marcador tumoral Ki-67 analisando a densidade óptica e o índice de marcagem no adenocarcinoma de estômago. Descrever a expressão citofotométrica do marcador tumoral Caspase-3 analisando a densidade óptica e o índice de marcagem no adenocarcinoma de estômago. Comparar o índice de marcagem e densidade óptica dos marcadores tumorais Ki-67 e Caspase-3 no adenocarcinoma de estômago. MÉTODO: Foram selecionados, inicialmente, 58 blocos com espécime de adenocarcinoma gástrico coletados nos Serviços de Anátomo-Patologia do Hospital do Gama - Brasília (DF e Hospital Dom Orione - Araguaina (TO, e analizados no Laboratório de Citologia e Histopalogia Ltda - CITOLAB, Curitiba (PR. Foram aproveitados 31 blocos para o estudo histológico e imunoistoquímico realizado pelo sistema de análise computarizado SAMBA 4000. RESULTADOS: Das 31 lâminas estudas, 15 (48% foram marcadas pelo marcador Ki-67, 22 (71% foram marcadas pelo marcador Caspase-3 e 14 (45% marcaram com os dois marcadores. CONCLUSÕES: A expressão citofométrica do marcador Ki-67 foi observada em 15 lâminas da amostra estudada e apresentaram média do índice de marcagem de 36,85%, enquanto a densidade óptica apresentou média de 29,33 pixels. A expressão citofotométrica do marcador Caspase-3 foi observada em 22 lâminas da amostra estudada e apresentaram média do índice de marcagem de 87,71% e 60,74 pixels de média para a densidade óptica. Na comparação do índice de marcagem dos

  2. Prevalência e achados epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários de cães da Região Central do Rio Grande do Sul (1965-2012

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    Mariana M. Flores

    2013-04-01

    Full Text Available A prevalência e os aspectos epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários (THMP em cães foram estudados. De 7.373 cães necropsiados em 48 anos (1965-2012, 64 morreram de THMP, o que corresponde a 0,9% do total de cães que morreram por qualquer causa, 7,8% do total de cães que morreram por tumores em geral e 33,5% do total de cães que morreram por tumores hepáticos. Desses 64 casos de THMP, 51 foram revistos histologicamente, avaliados imuno-histoquimicamente e reclassificados como carcinomas (colangiocarcinomas [n=36], carcinomas hepatocelulares [n=9] e hepatocolangiocarcinoma [n=1] e sarcomas (hemangiossarcomas [n=5]. Dos cães com colangiocarcinomas e carcinomas hepatocelulares em que a idade estava disponível nos protocolos, 64,7% e 77,8% eram idosos, respectivamente. Na necropsia, colangiocarcinomas caracterizaram-se principalmente por ocorrerem em um padrão multinodular (83,3%, enquanto carcinomas hepatocelulares ocorreram tanto de forma massiva (44,4% quanto nodular (44,4%. Metástases extra-hepáticas foram vistas em 77,8% e 33,3% dos casos de colangiocarcinomas e carcinomas hepatocelulares, respectivamente, e em relação aos colangiocarcinomas afetaram principalmente pulmões (52,8%, linfonodos (50% e peritônio (19,4%. Ascite (22,2% e icterícia (22,2% foram achados associados ocasionalmente com ambos os tumores. Na histologia, a maior parte dos colangiocarcinomas (86,1% e dos carcinomas hepatocelulares (55,6% tinha padrão tubular e trabecular, respectivamente. Na imuno-histoquímica, a maioria (63,9% dos colangiocarcinomas demonstrou imunomarcação para CK7 e nenhum imunomarcou para Hep Par 1. A maioria (55,6% dos carcinomas hepatocelulares demonstrou imunomarcação para Hep Par 1 e nenhum imunomarcou para CK7. Os resultados aqui apresentados demonstram uma altíssima prevalência de THMP, principalmente colangiocarcinomas, e servem para auxiliar, através dos

  3. Influência dos níveis de prolactina e tamanho tumoral na função hipofisária pós-operatória em macroadenomas hipofisários clinicamente não-funcionantes Influence of hyperprolactinemia and tumoral size in the postoperative pituitary function in clinically nonfuncioning pituitary macroadenomas

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    Ana Luiza Vidal Fonseca

    2002-09-01

    Full Text Available OBJETIVO: Estudar a influência da hiperprolactinemia e de tamanho tumoral na função hipofisária em macroadenomas hipofisários clinicamente não funcionantes. MÉTODOS: Foram analisados 23 pacientes com macroadenomas hipofisários clinicamente não funcionantes, com exames de imagem (tomografia computadorizada ou ressonância magnética e dosagens hormonais basais; 16 tinham provas de função hipotálamo-hipofisária (megateste pré-operatórios. Todos os tumores tiveram diagnóstico histológico e em 17 foi realizado também estudo imuno-histoquímico para os hormônios adeno-hipofisários. A análise estatística foi feita por meio dos testes t de Student, qui-quadrado, exato de Fisher e de Mc Neman. O nível de significância adotado foi 5% (pOBJECTIVE: To study the influence of hyperprolactinemia and tumoral size in the pituitary function in clinically nonfuncioning pituitary macroadenomas. METHODS: Twenty three patients with clinically nonfuncioning pituitary macroadenomas were evaluated by image studies (computed tomography or magnetic resonance and basal hormonal level; 16 had preoperative hypothalamus-hypophysial function tests (megatests. All tumors had histological diagnosis and in seventeen immunohistochemical study for adenohypophysial hormones was also performed. Student's t test, chi square test, exact test of Fisher and Mc Neman test were used for the statistics analysis . The level of significance adopted was 5% (p<0.05. RESULTS: Tumoral diameter varied of 1.1 to 4.7 cm (average=2.99 cm ± 1.04. In the preoperative, 5 (21.7% patients did not show laboratorial hormonal deficit, 9 (39.1% developed hyperprolactinemia, 13 (56,5% normal levels of prolactin (PRL and 1 (4.3% subnormal; 18 (78.3% patients developed hypopituitarism (4 pan-hypopituitarism. Nineteen patients (82.6% underwent transsfenoidal approach, 3 (13% craniotomy and 1 (4.4% combined access. Only 6 patients had total tumoral resection. Of the 17 immunohistochemical

  4. Diagnóstico e prognóstico dos tumores pulmonares neuroendócrinos mediante microscopia eletrônica e análise multivariavel de agrupamento Using electron microscopy and multivariate cluster analysis to determine diagnosis and prognosis in cases of neuroendocrine lung carcinoma

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    Cecília Aparecida Vaiano Farhat

    2008-10-01

    Full Text Available OBJETIVO: Estabelecer, com ajuda do microscópio eletrônico, critérios que possibilitem uma diferenciação mais exata entre os quatro tipos maiores de tumores neuroendócrinos pulmonares: tumor carcinóide típico e atípico, carcinoma de grandes células neuroendócrino e carcinoma de pequenas células. MÉTODOS: Todos os tumores foram avaliados morfometricamente e 16 variáveis foram relacionadas com diferenciação das células tumorais; estas variáveis foram analisadas sob microscopia eletrônica com ajuda de um analisador de imagem digital em 27 tumores. A avaliação através da microscopia eletrônica revelou que todos os tumors investigados podiam ser classificados a um dos quarto tipos listados acima. A análise das variáveis morfométricas foi usada para agrupar os tumores em três grandes grupos, os quais foram relacionados à sobrevivência pelas curvas de Kaplan Meier. RESULTADOS: Os três grupos de carcinoma neuroendócrino associaram-se às curvas da sobrevivência, as quais mostraram características ultrastruturais na microscopia eletrônica de significância prognóstica distinta. Os tumores foram contidos em três grupos bem definidos, que representam o espectro da diferenciação neuroendócrina: tumor carcinóide (grupo 1; tumor carcinóide atípico e carcinoma de grandes células neuroendócrino (grupo 2; e carcinoma de pequenas células (grupo 3. O grupo 2 representa um espectro intermediário na carcinogênese neuroendócrina, entre o carcinóide típico e o carcinoma de pequenas células. CONCLUSÕES: Nossos achados confirmam que a microscopia eletrônica é uma ferramenta útil no diagnóstico e prognóstico dos casos de tumores pulmonares.OBJECTIVE: To establish reproducible electron microscopic criteria for identifying the four major types of neuroendocrine tumors of the lung: carcinoid; atypical carcinoid; large cell neuroendocrine carcinoma; and small cell carcinoma. METHODS: Measurements were made on electron

  5. Competencies evaluation of the petroleum industry local suppliers; Avaliacao de competencias dos fornecedores locais da industria do petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Marzani, Bianca Santos; Furtado, Andre Tosi [Universidade Estadual de Campinas, SP (Brazil). Inst. de Geociencias. Dept. de Politica Cientifica e Tecnologica]. E-mail: bianca@ige.unicamp.br; furtado@ige.unicamp.br

    2003-07-01

    This article presents a research proposition that focuses on competencies evaluation of the local suppliers of goods and services in the petroleum industry. Because of the new context created by the opening of the petroleum market the suppliers to face a new competition environment, exposed to the foreign suppliers that operate in a higher production scale and have great financial and technological capacities. This justifies the development of the current study because the final diagnosis will help the studied companies in their decision process by the divulgation of their weaknesses and potentialities, which will motivate an improvement in the sector. In this paper, we include technological, organizational and relational competencies. Moreover, some of the main contributions of the literature about these topics are presented, including Lall, Kim, Figueiredo, Furtado, Munier, etc. (author)

  6. Evaluation of collective protection equipment in a hemodynamic room; Avaliacao dos equipamentos de protecao coletiva em uma sala de hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Casagrande, Saman; Silva, Ana Maria Marques da, E-mail: saman.casagrande@acad.pucrs.br, E-mail: ana.marques@pucrs.br [Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil); Real, Jessica Villa; Luz, Renata Matos da, E-mail: jessica.real@acad.pucrs.br, E-mail: renata.luz@pucrs.br [Hospital Sao Lucas (HSL/PUCRS), Porto Alegre, RS (Brazil)

    2014-07-01

    Interventional radiology has high occupational dose rates. The use of personal protective equipment (PPE) and collective protection (ECP) help to reduce the dose delivered to the individuals occupationally exposed (IOE). In order to minimize the exposure of IOE's in interventionists procedures, evaluated the attenuation of the secondary radiation produced by collective protection equipment (CPE), was used a chest non-anthropomorphic phantom of polymethylmethacrylates (PMMA), with column simulator in aluminum, with variable thicknesses and kerma rate measures the air by varying the frequency tables 15 and 30 frames / s and different exposure modes. Data were acquired initially at the height of 1.25 m, using the following combinations of the ECP: (I) unshielded, (II) with plumbum display, (III) combining skirt + display. Measured at a height of 0.5 m were acquired with and without skirt. The attenuation ranged from 83.8% to 95.4% for a thickness of 25 cm. The maximum attenuation occurred with the combination of display and skirt. There was a 5 time increase in air kerma rate to be used cine display mode, when compared to the low mode. By analyzing the frequency of the frames were obtained differences up to 3 times higher for 30 frames / s, when compared with 15 frames / s. The results show the importance of using ECP in hemodynamics services, which together with the PPE, ensure adequate protection for IOEs.

  7. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

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    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  8. Expressão imuno-histoquímica de p53 na discriminação do comportamento biológico dos tumores de glândulas salivares Immunohistochemical expression of p53 on the biological behavior of salivary gland tumors

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    Kelen Christine do Nascimento Souza

    2005-06-01

    Full Text Available INTRODUÇÃO: Mutações no gene TP53 têm sido identificadas em várias neoplasias, incluindo as de glândulas salivares (NGS. Entretanto não existe consenso sobre o significado biológico da expressão de p53 nessas lesões. OBJETIVOS: Avaliar a marcação imuno-histoquímica do antígeno p53 em NGS, investigando possíveis diferenças entre lesões benignas e malignas, entre diferentes tipos histológicos e entre tumores malignos que: 1 não desenvolveram metástases; 2 emitiram metástases; e 3 metástases de NGS. MATERIAL E MÉTODO: Foram avaliados 16 casos de adenomas pleomórficos (AP, 17 lesões malignas que não apresentaram metástase durante a proservação (sete carcinomas adenóides císticos [CAC] e dez mucoepidermóides [CM], 13 tumores malignos que emitiram metástases (nove CAC e quatro CM e, ainda, 12 metástases regionais ou distantes (cinco CAC e sete CM. Por marcação imuno-histoquímica (estreptavidina-biotina-peroxidase, índices médios de localização do antígeno p53 foram estabelecidos para cada tumor. Para análise, utilizaram-se testes de Mann-Whitney e Kruskal-Wallis, com nível de significância de 5%. RESULTADOS: Foram observadas diferenças estatisticamente significantes nos índices médios de imunomarcação de p53 entre lesões benignas e malignas (p = 0,03 e entre os diferentes tipos histológicos, notadamente entre o AP e o CM (p = 0,02. Todavia houve marcada sobreposição dos intervalos de índices de expressão entre os grupos testados. Nenhuma diferença de expressão foi observada entre as neoplasias malignas quanto ao seu comportamento metastático. CONCLUSÃO: Embora a expressão de p53 tenha sido detectada em todos os subtipos de NGS, a marcação imuno-histoquímica deste antígeno não permitiu discriminar os tumores malignos quanto ao seu comportamento biológico.BACKGROUND: Mutations in the tumor suppressor gene TP53 have been found in many tumors, including salivary gland neoplasms (SGN

  9. Estudo citofotométrico da expressão dos marcadores tumorais Ki-67 e CD34 no adenocarcinoma de próstata Cytophotometric expression of tumor antigen markers Ki-67 and CD-34 in prostate adenocarcinoma

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    Paulo Faria Barbosa

    2009-12-01

    Full Text Available OBJETIVO: Quantificar a porcentagem da imunomarcação no índice de marcagem e densidade óptica do Ki-67 e CD34 no adenocarcinoma de próstata e compará-las entre si. MÉTODOS: Foram estudados, através de imunoistoquímica, o Ki-67 e o CD34 em 34 casos de adenocarcinoma de próstata provenientes de prostatectomia radical no período de 2000 a 2005 realizado no Hospital Regional do Gama em Brasília. Estes marcadores foram quantificados através do software SAMBA 4000 ® Sistema de Análise Microscópica de Busca Automática e do software IMMUNO® para análise das variáveis índice de marcagem e densidade óptica. Para avaliação da associação entre as expressões do marcador, foi estimado o coeficiente de correlação de Spearman. Para a comparação do tipo de lesão, foi usado o teste t de Student em amostras pareadas e não paramétrico de Wilcoxon. RESULTADOS: Dos 34 blocos que foram para leitura dos marcadores tumorais, 15 marcaram expressão com Ki-67, 34 com CD34 e 14 com ambos os marcadores. O índice de marcagem do CD34 teve valor mediano de 72,72%, valor mínimo 5,14% e valor máximo 88,81%. O índice de marcagem do Ki-67 teve mediana de 73,78%, mínimo de 16,87% e máximo de 87,47%. A densidade óptica do CD34 teve mediana de 48,33, mínimo de 35,65 e máximo de 85,86. Na densidade óptica do Ki-67 o valor da mediana foi 40,03 sendo a mínima de 21,53 e a máxima de 52,43. CONCLUSÃO: A expressão citofotométrica do Ki-67 teve índice médio de marcação de 64,04% e o CD34 de 61,64%. A expressão citofotométrica da densidade óptica média do Ki-67 foi de 39,49 e no CD34 de 53,69. Há diferença significativa entre a imunomarcação do Ki-67 e CD34 em relação à densidade óptica (p=0,025, não havendo diferença significativa no índice de marcagem (p=0,470.OBJECTIVE: To quantify the percentage of immunostaining through the labeling index as well as the optical density of Ki-67 and CD34 in prostate adenocarcinoma and

  10. Ultra-estrutura dos mastócitos de diferentes tipos histológicos de mastocitoma em cães Mast cell ultrastructure in different types of canine mast cell tumor

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    F.A.R. Sueiro

    2002-06-01

    Full Text Available Este trabalho teve por objetivo estudar as diferenças ultraestruturais de mastócitos neoplásicos de diferentes tipos histológicos de mastocitoma em cães, usando microscopia eletrônica de transmissão Os resultados mostraram que o núcleo e os grânulos citoplasmáticos são as estruturas mais indicadas para se avaliar o grau de anaplasia celular e o estádio de indiferenciação do tumor.The objective of this work was study the ultrastructural differences among the different histologic types of mast cell tumors in dogs collected in vivo. The ultrastructural analyses showed that the nuclei and cytoplasmic granules characteristics are the best structures to be appointed on evaluating the undifferentiation stage of this tumor.

  11. Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology Neoplasias orais em cães: avaliação dos aspectos clínicos, histopatologia e citologia esfoliativa

    Directory of Open Access Journals (Sweden)

    Cláudia Ronca Felizzola

    1999-09-01

    Full Text Available In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma; 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells. These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.Objetivou-se o estudo comparativo em tumores de cavidade bucal de animais de espécie canina de acordo com sexo, faixa etária, raça, aspectos clínicos, citologia esfoliativa e histopatologia, para estabelecer diagnóstico dessas neoplasias, tendo sido utilizados 130 cães, encaminhados ao Hospital Veterinário (HOVET da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os resultados obtidos na citologia esfoliativa foram: 100% de negativos para neoplasias benignas não odontogênicas; 97,91% de negativos para neoplasias benignas odontôgenicas e 77,92% de positivos para neoplasias malignas. Obtiveram-se os seguintes resultados no exame histopatológico: neoplasias malignas - 59,23% (melanoma 33,08%, carcinoma epidermóide 9,23%, osteossarcoma 5,38%, fibrossarcoma 2,31%, angiossarcoma 2

  12. Aplicação clínica dos marcadores tumorais séricos em carcinoma não-pequenas células do pulmão Clinical application of serum tumor markers in patients with non-small cell lung carcinoma

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    JEFFERSON LUIZ GROSS

    2000-08-01

    Full Text Available O valor clínico dos marcadores tumorais séricos em câncer de pulmão é incerto. Objetivos: Avaliar a associação da concentração sérica de marcadores tumorais com a extensão da neoplasia e seu valor prognóstico. Casuística e método: Entre fevereiro de 1995 e setembro de 1997 foram estudados 103 pacientes, no Departamento de Cirurgia Torácica do Hospital do Câncer. Antes do tratamento os pacientes foram submetidos à coleta de sangue para dosagem da concentração do CEA, CYFRA21.1, CA15.3, CA19.9, CA72.4 e NSE. Resultados: O CYFRA21.1 foi o marcador mais freqüentemente elevado (55%. Os pacientes com neoplasia avançada tiveram concentração sérica média do CEA (90,82 ± 329,08ng/ml, CYFRA21.1 (20,34 ± 58,42ng/ml e CA15.3 (56,54 ± 86,81U/ml significativamente superior às observadas nos tumores localizados, respectivamente, 10,24 ± 35,96ng/ml, 12,67 ± 25,23ng/ml e 22,22 ± 15,86U/ml. Mesmo considerando todos os marcadores deste estudo, apenas os pacientes com CEA elevado tiveram chance 5,6 vezes maior de ser portadores de neoplasia avançada, quando comparados com aqueles com CEA normal. A sobrevida foi influenciada pelo performance status (p = 0,001, extensão anatômica (p = 0,006, concentração aumentada do CEA (p = 0,043, mais que dois marcadores aumentados (p The usefulness of serum tumor markers in lung cancer is not well defined. Objective: The aim of this study is to examine the correlation between serum tumor markers and tumor extension and its prognostic value. Patients and method: From February 1995 to September 1997, 103 patients with non-small cell lung carcinoma were evaluated at the Department of Thoracic Surgery. Serum levels of CEA, CYFRA21.1, CA15.3, CA19.9, CA72.4, and NSE were determined before treatment. Results: The serum level of CYFRA21.1 was the most frequent elevated tumor marker (55%. Patients with advanced tumor had higher mean serum level of CEA (90.8 ng/ml, CYFRA21.1 (20.3 ng/ml and CA15.3 (56

  13. Tumores cartilaginosos da laringe

    Directory of Open Access Journals (Sweden)

    Thomé Robert

    2001-01-01

    Full Text Available Introdução: Os tumores cartilaginosos da laringe são raros, sendo a cartilagem cricóide a mais acometida. A raridade desses tumores tem como conseqüência experiência limitada e, portanto, o conhecimento a respeito destas neoplasias apresenta pontos obscuros. Objetivo: Apresentar os resultados cirúrgicos bem como o seguimento a longo prazo de 6 pacientes com tumores cartilaginosos da laringe, 4 condrossarcomas de baixa malignidade e 2 condromas. Forma de estudo: Retrospectivo não randomizado. Material e método: Cinco dos tumores acometiam a cartilagem cricóide e 1 a tireóide. Os pacientes foram submetidos a laringectomia parcial (4 e total (2, com seguimento de 6 a 30 anos (média-19,5 anos. Resultados: Nenhum dos pacientes apresentou metástase ou morte relacionada ao tumor. A sobrevida alcançada por 5 anos foi de 100% e a por 20 anos, 67%, sendo a comorbidade responsável por tal decréscimo. Conclusões: Nossos resultados reforçam o conceito de que a laringectomia conservadora seja a modalidade ideal de tratamento, reservando a ressecção total para tumores extensos ou casos de recorrência. Há indícios de que 5 anos pode não ser tempo suficiente para observar recorrência no condrossarcoma de baixo grau de malignidade.

  14. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  15. Classificação dos tumores da mama: atualização baseada na nova classificação da Organização Mundial da Saúde de 2012 Classification of tumours of the breast: an update based on the new 2012 World Health Organization Classification

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    Helenice Gobbi

    2012-12-01

    Full Text Available A Organização Mundial da Saúde lançou em julho de 2012 a 4ª edição da Classificação dos Tumores de Mama. Nesta revisão, será realizada uma breve abordagem das principais mudanças da nova classificação, com ênfase nas implicações diagnósticas e terapêuticas. As principais mudanças foram: (i o fascículo atual é dedicado integralmente aos tumores da mama; (ii os tumores epiteliais foram agrupados de forma diferente, com o reconhecimento de nove tipos especiais e suas variantes e 11 tipos raros de tumores mamários, além do carcinoma ductal invasivo sem outra especificação. Foram reconhecidos e incluídos novos códigos para as variantes de carcinoma lobular, carcinomas com características medulares e subtipos de carcinomas metaplásicos; (iii foram sugeridos novos escores para avaliação imuno-histoquímica de receptores hormonais (> 1% de células positivas e receptor do fator de crescimento epidérmico 2 (HER2 (> 30% células fortemente positivas, circundando toda membrana; (iv apresentou-se nova abordagem da classificação molecular e genômica do câncer de mama, incluindo novos testes que empregam perfil de expressão gênica para predição da evolução clínica e resposta terapêutica; (v foi mantida a terminologia tradicional das lesões proliferativas intraductais, não se adotando a terminologia neoplasia intraepitelial ductal; (vi reconheceu-se a importância prognóstica de se distinguir hiperplasia lobular atípica e carcinoma lobular in situ (CLIS dentro do espectro das neoplasias lobulares; (vii as lesões de células colunares (alteração e hiperplasia de células colunares sem atipias foram separadas das atipias epiteliais planas, cuja evolução biológica ainda é pouco definida. Espera-se amplo uso da nova classificação, por patologistas e oncologistas, beneficiando pacientes, alvos principais dos avanços diagnósticos e terapêuticos.The World Health Organization released the 4th edition of

  16. AVALIAÇÃO BIOQUÍMICA DO ÁCIDO SIÁLICO COMO BIOMARCADOR TUMORAL EM NOVILHAS CRIADAS EM PROPRIEDADE ENDÊMICA PARA HEMATÚRIA ENZOÓTICA DOS BOVINOS

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    MARCOS COELHO DE CARVALHO

    2011-06-01

    Full Text Available Pteridium aquilinum (bracken fern is one of the most concerning toxic vegetables in many countries in the world. Therefore, science aims to find ways for the epidemiological control of bovine intoxication with the purpose of making early diagnoses of Bovine Enzootic Hematuriae. Researches have shown a high correlation between the excessive production of mucoprotein by animals with Bovine Enzootic Hematuriae and sialic acid, proving that this acid acts as an inflammatorybiochemical marker associated to bladder tumor development. Based on this information, serum sialic acid levels of clinically healthy Nellore heifers (control group were statistically compared to Nellore heifers raised in bracken fern endemic properties (experimental group. The average level of serum sialic acid of the control groups was not different from the sialic acid level of the affected group (0.611 ± 0.225 g/L and 0.615 ± 0.258 g/L, respectively. Results obtained in the present study demonstrate no differences of the sialic acid average levels between the groups. Therefore, measurement ofsialic acid serum levels was not effective as a neoplasic biochemical marker in Nellore heifers continuously fed with bracken fern.

  17. A comparative study of ultrasonography, computed tomography and magnetic resonance imaging in the staging and invasion of adjacent structures by renal tumors; Estudo comparativo dos metodos de ultrassonografia, tomografia computadorizada e ressonancia magnetica no estadiamento e invasao das estruturas adjacentes por tumores renais

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, S.M.; Ajzen, S.A.; Trindade, J.C.S. [Universidade Federal de Sao Paulo (UNIFESP), SP (Brazil). Faculdade de Medicina; UNESP, Botucatu, SP (Brazil). Faculdade de Medicina; E-mail: sribeiro@fmb.unesp.br

    2001-09-01

    Ultrasonography (US), Computed Tomography (CT), and Magnetic Resonance imaging (MR) were compared for the staging of renal tumors. The differences between these imaging techniques were also studied for their ability to detect adenopathies, vascular invasion, distant intra-abdominal metastases, and particularly adjacent organ invasion. Thirty-one patients with solid or complex renal masses were prospectively studied using US, CT, and MR. Differences between the results obtained were studied using the Cochran G test and the Mc NEMAR test. The sensitivity and specificity of each diagnostic technique were compared against a 'gold standard' of the surgical and histopathological findings. The following sensitivities were obtained: For the detection of adenopathy, US 63.6%, CT and MR 90.9%. For vascular invasion, US 42.8%, CT and MR 85.7%. For the adjacent organ invasion, US 28.5%, CT 85.7%, and MR 71.4%. Some of the criteria that suggest invasion of adjacent structures include: the envelopment of the adjacent structures by the tumor, tumor extension into the adjacent structures with an irregular appearance, and alterations in shape, size, and density of adjacent structures. Loss of fat planes between the tumor and adjacent structures is not a sign of tumor invasion. Significant differences were found in the detection capacity of US in relation to CT and MR, which were similar. All three techniques were highly sensitive and specific only in the detection of distant abdominal metastases. In addition to the accuracy of these diagnostic modalities for the detection and staging of tumors, invasiveness, risks and cost should be considered in relation to relative costs and benefits. (author)

  18. Dos cupas complutenses

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    Stylow, Armin U.

    2006-12-01

    Full Text Available Publication of two cupae from the ancient territory of Complutum. One was found in excavations in Alcalá de Henares (Madrid and is unpublished; of the other one, which came to light in the church of Alovera (Guadalajara, a new reading is given.Se publican dos cupas del antiguo territorio de Complutum, una, inédita, encontrada en excavación en Alcalá de Henares (Madrid, y la segunda, procedente de la iglesia de Alovera (Guadalajara, con una nueva lectura.

  19. dos estudios de caso

    Directory of Open Access Journals (Sweden)

    Daniel Kersffeld

    2013-01-01

    Full Text Available La UNASUR se ha destacado desde sus inicios en la compleja labor de mediación y resolución de conflictos internacionales. Para ello, esta entidad multilateral ha apelado a distintas fórmulas políticas tendientes al encausamiento de problemáticas y conflictos apartados del camino de la institucionalidad y de los medios tradicionales de resolución. Con todo, y pese a la búsqueda de caminos alternativos, han sido las cumbres presidenciales la principal herramienta destinada a encontrar soluciones innovadoras y respetuosas del orden democrático y constitucional de los países sudamericanos. En este artículo se analiza de manera específica la actuación de la unasur en dos casos de profunda gravedad institucional: el intento de golpe de Estado ocurrido en Ecuador el 30 de septiembre de 2010 y el derrocamiento del ex presidente Fernando Lugo en Paraguay en junio de 2012. Luego de analizar estos dos casos extremos, y las implicancias políticas generadas, se avanza en una visión comprensiva acerca del éxito o el fracaso del papel político de la unasur como instancia de resolución de conflictos a nivel internacional.

  20. Tumor estromal gastrointestinal: estudo de oito casos

    OpenAIRE

    Amico Enio Campos; Coimbra Cesar Wilson Bastos; Bugalho Luiz Antônio; Nai Gisele Alborghetti; Matos Ricardo Marcondes; Machado Cibele Chuery; Silva Fabrício Colacino

    2006-01-01

    OBJETIVO: O diagnóstico e tratamento dos tumores estromais gastrointestinais (TEGI) têm evoluído a partir de estudos recentes de genética e biologia molecular. Tais avanços têm refletido em melhor sobrevivência dos doentes. MÉTODOS: Foi realizado estudo retrospectivo no período de novembro/1998 a julho/2004, em instituição universitária e em clínica privada dos autores, que identificou portadores de TEGI a partir de positividade para c-kit (CD 117), ao exame imunoistoquímico. RESULTADOS: Dos ...

  1. Tumor vaccines

    International Nuclear Information System (INIS)

    Tumor vaccines have several potential advantages over standard anticancer regiments. They represent highly specific anticancer therapy. Inducing tumor-specific memory T-lymphocytes, they have potential for long-lived antitumor effects. However, clinical trials, in which cancer patients were vaccinated with tumor vaccines, have been so far mainly disappointing. There are many reasons for the inefficiency of tumor vaccines. Most cancer antigens are normal self-molecules to which immune tolerance exists. That is why the population of tumor-specific lymphocytes is represented by a small number of low-affinity T-lymphocytes that induce weak antitumor immune response. Simultaneously, tumors evolve many mechanisms to actively evade immune system, what makes them poorly immunogenic or even tolerogenic. Novel immunotherapeutic strategies are directed toward breaking immune tolerance to tumor antigens, enhancing immunogenicity of tumor vaccines and overcoming mechanisms of tumor escape. There are several approaches, unfortunately, all of them still far away from an ideal tumor vaccine that would reject a tumor. Difficulties in the activation of antitumor immune response by tumor vaccines have led to the development of alternative immunotherapeutic strategies that directly focus on effector mechanisms of immune system (adoptive tumor- specific T-lymphocyte transfer and tumor specific monoclonal antibodies). (author)

  2. Palavras dos editores

    Directory of Open Access Journals (Sweden)

    Nelkis de la Orden Medina

    2005-12-01

    Full Text Available Este número da revista RESI está sendo editado em conjunto por mim e pelo novo editor Jorge Muniz Barreto. A revista tem agora nova sede, o Departamento de Informática e de Estatística da Universidade Federal de Santa Catarina. No que a me diz respeito, tenho a satisfação após estes 4 anos de trabalho de ter contribuído no lançamento e consolidação da revista, a qual considero uma ferramenta útil no âmbito universitário. Agradeço a todos os que fizeram possível a realização deste projeto: aos membros do conselho editorial, ao corpo de avaliadores e principalmente aos autores de trabalhos publicados. Gostaria de agradecer ao novo editor sua excelente disposição para aceitar este desafio e lhe desejo uma gestão editorial de muito sucesso. Tenho a certeza que estamos iniciando uma nova etapa da revista que permitirá um crescimento maior da mesma, na qual continuaremos a colaborar de forma permanente. Campo Largo, dezembro de 2005. Nelkis de la Orden Medina, Editora-Chefe. Repletos de idealismo iniciamos com a edição 6 da Revista Eletrônica de Sistemas de Informação nossa atuação como Editor-Chefe. Esperamos honrar os sucessos obtidos pela revista nos cinco números anteriores, e tornar RESI, cada vez mais útil a seus leitores. Para isto temos planos e contamos além do Conselho Editorial e Revisores, ouvir também a opinião dos leitores de modo informal. Para isto criamos um MSN-Space onde os leitores poderão colocar suas sugestões (operacional e conhecer alguns membros tanto do conselho como revisores. Para vê-lo acessem:http://spaces.msn.com/members/resireveletron Os trabalhos apresentados dão continuidade ao estilo das edições anteriores. São seis artigos, abordando assuntos relacionados à Sistemas de Informação. Estes artigos enriquecem o acervo de trabalhos publicados na revista RESI e mostram o panorama das pesquisas que estão sendo desenvolvidas no Brasil e países amigos. Dentre os planos para o ano

  3. Classificação dos tumores hematopoéticos e linfoides de acordo com a OMS: padronização da nomenclatura em língua portuguesa, 4ª edição Classification of haematopoietic and lymphoid tumors: WHO, standardization of nomenclature in Portuguese, 4th edition

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    Maria Cláudia Nogueira Zerbini

    2011-12-01

    Full Text Available INTRODUÇÃO: A classificação da Organização Mundial da Saúde (OMS para os tumores do tecido hematopoético e linfoide (4ª edição, 2008 representa uma revisão atualização da 3ª edição publicada em 2001. A tradução da nomenclatura utilizada para identificar as entidades descritas deve ser clara, precisa e uniforme no sentido de reproduzir de forma correta as diversas entidades clinicopatológicas para clínicos, patologistas e pesquisadores envolvidos na área da onco-hematopatologia. OBJETIVO: Os autores apresentam uma proposta de atualização e padronização terminológica em língua portuguesa, com base na OMS/2008INTRODUCTION: The World Health Organization (WHO classification of hematopoietic and lymphoid tissue (4th edition, 2008 tumors constitutes an updated review of the 3rd edition published in 2001. The translation of the nomenclature used to describe the entities should be clear, precise and uniform so that clinicians, pathologists and researchers involved in the onco-hematopathological area may identify them accurately. OBJECTIVE: With this purpose, the authors present an updated proposal and a terminological standardization in Portuguese based on WHO/2008

  4. Evaluation of medical residents exposed to X-ray during surgical procedures; Avaliacao dos medicos residentes expostos aos raios-X durante procedimentos cirurgicos

    Energy Technology Data Exchange (ETDEWEB)

    Alabarse, F.G.; Leal, R.; Amador, G.B.; Bacelar, A. [Hospital de Clinicas de Porto Alegre, RS (Brazil). Fisica Medica. Servico de Engenharia Biomedica; Westphal, M.; Furtado, A.P.A. [Hospital de Clinicas de Porto Alegre, RS (Brazil). Fisica Medica. Servico de Radiologia]. E-mail: abacelar@hcpa.ufrgs.br

    2001-07-01

    This work present some evaluations in relation to the Medical Resident that work with X-rays during surgery procedures. The objective is discovery what the staff that make more use of this kind of radiation during their procedures and evaluate the relation with their respective doses. The information was toke during the activities that make some use of X-rays. This information was connected with the respective dose of Medical Resident. The results is that the worker of Medical Resident is the worker that are most in exposure in a surgery unit. The staff that use X-rays with more frequency and have the biggest time in exposure is Orthopedy and Traumathology. The highest dose that they received were of 22,72 mSv, in a Resident of the Urology group. (author)

  5. Effects of blue light irradiation on dental enamel remineralization in vitro; Avaliacao dos efeitos promovidos pela radiacao azul na remineralizacao do esmalte dentario in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Ilka Tiemy

    2009-07-01

    This study aimed to investigate the effects of blue radiation on dental enamel remineralization. In addition, a methodology of analysis was developed to evaluate alterations of enamel mineral content by optical coherence tomography. Artificial lesions were formed in bovine dental enamel slabs by immersing the samples in under saturated acetate buffer (2 mL/mm{sup 2} e 6.25 mL/mm{sup 2}). The lesions were irradiated with blue LED (l=455{+-}20nm), with radiant power of 110 mW, irradiance of 1.4 W/cm{sup 2}, radiant exposure of 13.8 J/{sup c}m2 and exposure time of 10 s. Remineralization was induced by pH-cycling model during 8 days. Cross-sectional hardness and optical coherence tomography (OCT) were used to assess mineral changes after remineralization. Hardness data showed that non-irradiated enamel lesions presented higher mineral content than irradiated ones and this difference was more evident in lesions formed in higher solution volume. The analysis of OCT signal also demonstrated that the mineral content of non-irradiated group was higher than in irradiated one; however, no significant difference was observed. Furthermore, significant differences in OCT sign were detected between sound and demineralized enamel. Based on the results obtained in the present study it can be concluded that blue radiation caused an inhibition of enamel remineralization. The methodology adopted for OCT analysis allowed the quantification of enamel mineral loss; however, the remineralization process could not be evaluated by this technique. (author)

  6. Evaluation of the normal thoracic and abdominal aorta diameters by computerized tomography; Avaliacao dos diametros normais da aorta toracica e abdominal pela tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Lucarelli, Claudio Luiz

    1995-07-01

    The study was undertaken to evaluate, through computerized tomography, the diameters of the normal thoracic and abdominal aorta, as well as they are connected to gender, age and body surface area; and the ratio between measurements obtained at the ascending and descending limbs of the thoracic aorta, and between the abdominal aortic diameters. For that reason, we measured the widest anteroposterior diameters of the thoracic aortas at the levels of the arch, the root, the pulmonary artery, and the thoracic-abdominal transition, as well as the level of the emergence of the superior mesenteric artery, of the renal hila and just cephalad to the bifurcation of the abdominal aortas of 350 patients without cardiovascular diseases who had undergone computerized tomography of the thorax and/or abdomen for any other reasons. Observation and statistic analyses led us to conclude that: 1) both the thoracic and abdominal aortic diameters are reduced from their proximal to their distal portions; 2) the body surface influences the size of the aorta, although only extreme variations alter the vessel's caliber; 3) vessel diameter was observed to gradually increase with age; 4) men were found to have larger diameters than age matched women; 5) the ratio between the ascending and descending aortic diameters varies according to gender and age; 6) the relations between abdominal aortic diameters measured at the level of renal hila and cephalad to the bifurcation are independent from gender and age. But the relation between those measured at the level of the superior mesenteric artery and cephalad to the bifurcation are linked to gender, but not to age. (author)

  7. Quality of life evaluation of workers for diagnostic radiology services; Avaliacao da qualidade de vida dos trabalhadores de servicos de radiodiagnostico

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    Fernandes, Ivani Martins

    2011-07-01

    The main objective of this study was to evaluate the quality of life (QOL) of diagnostic radiology services workers at a hospital of Sao Paulo city. It aimed also to draw the profile of these workers identifying the variables, as its influence on their quality of life. A descriptive exploratory study with qualitative and quantitative approaches was carried out. The data were collected using the questionnaires: the abbreviated instrument for the assessment of the QOL, World Health Organization Quality of Life Instrument bref (WHOQOL-bref) and a questionnaire including the social demographic variables, work conditions and the variables that express the lifestyle of individuals, both questionnaires self-applied. The sample was formed by 118 workers, among them: physicians, technologists/technicians in radiology, nurses, technicians and assistants in nursing, and others health professionals. The data analysis included descriptive statistics, nonparametric tests and the use of a linear regression model. The reliability of the instrument for the studied sample was verified by Cronbach's Alpha Coefficient ({alpha}). The WHOQOL-bref proved to be an adequate instrument, with a good level of internal consistency ({alpha}=0.884), being easily and quickly administrated for the evaluation of the QOL. The study provided an overview of the perception of quality of life of the studied group. (author)

  8. Evaluation of occupational dose from the special procedures guided by fluoroscopy: cardiac catheterism; Avaliacao da dose ocupacional oriunda dos procedimentos especiais guiados por fluoroscopia: cateterismo cardiaco

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Amanda Juliene da

    2011-07-01

    The purpose of this study was to evaluate the dose received by health professionals in the hemodynamic sector of a university hospital in Sao Paulo city. A self-applied questionnaire was used to delineate the profile of health professionals, taking into account sociodemographic variables and variables related to the work with ionizing radiation. The assessment of occupational doses was performed by consulting of the individual dose records of the institution database from 2000 to 2009. A total of 240 records was evaluated, corresponding to 38 active professionals (2009), divided in different professional category: physician, nurses, radiologic technologists and nursing assistants. The annual doses were compared with the limits established by national regulatory authorities. Based on the effective doses received and recorded during the studied period, experimental measures were performed with TL dosimeters in five physicians to evaluate the equivalent dose, in the left hand, during hemodynamic procedures. In addition, the radioprotection measures adopted by health professionals were verified. This study allowed delineating the profile of medical staff that integrates the hemodynamic service as well as knowing the distribution of their doses in relation to limits over the years. (author)

  9. Evaluation of occupational exposure in interventionist procedures using Monte Carlo Method; Avaliacao das exposicoes dos envolvidos em procedimentos intervencionistas usando metodo Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Santos, William S.; Neves, Lucio P.; Perini, Ana P.; Caldas, Linda V.E., E-mail: williathan@yahoo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Belinato, Walmir; Maia, Ana F. [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Departamento de Fisica

    2014-07-01

    This study presents a computational model of exposure for a patient, cardiologist and nurse in a typical scenario of cardiac interventional procedures. In this case a set of conversion coefficient (CC) for effective dose (E) in terms of kerma-area product (KAP) for all individuals involved using seven different energy spectra and eight beam projections. The CC was also calculated for the entrance skin dose (ESD) normalized to the PKA for the patient. All individuals were represented by anthropomorphic phantoms incorporated in a radiation transport code based on Monte Carlo simulation. (author)

  10. Impact of an evaluation quality program of mammography service of Distrito Federal - Brasil; Impacto de um programa de avaliacao da qualidade dos servicos de mamografia do Distrito Federal

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Rosangela da Silveira

    2002-07-01

    Cancer is the second cause of death for Brazilian women and breast cancer is the most common neoplasm amongst women. Mammography is an essential tool for diagnosis and early detection of this disease. In order to be effective, the mammography must be of good quality. This study sought to evaluate the quality of these services in the Federal District and the impact of an intervention involving inspection and education. The universe of 41 mammography services in the Federal District was studied between June and August 2001. Two instruments were used 1) a proposed evaluation protocol of the National Agency for Health Surveillance (ANVISA) and 2) a protocol for evaluation of image quality and care. The intervention included the initial inspection, a training activity, and a formal notification by the health authorities of the Federal District. Image quality was compared before and after the intervention. The existing infrastructure in the DF is of good quality, but the services have low productivity, they do not treat patients sent by the public health system, they have an inadequate geographic distribution with most in the central neighborhood, and the low income female population has restricted access to early detection of cancer. Of the 36 services who completed the study, none was above 90% conformity in image quality before the interventions, whereas 10 were above 90% afterwards. The greatest improvements were in chassis maintenance (services without chassis with defects went from 10 to 25), breast compression (services in conformity went from 7 to 20) and visualization of micro calcifications (32 services in conformity before and 35 afterwards). The results of the ANVISA protocol bore no relation to final image quality, a central issue for early cancer detection. In spite of the existence of many services, most were not of quality and population access was restricted. The intervention under study was shown to be effective for improving quality, nevertheless ongoing action is needed to resolve the remaining problems and to increase the impact. The proposed method for public monitoring should be modified to evaluate primarily the quality of the final exam provided to the consumer. (author)

  11. Evaluation of advanced oxidative processes in contaminated soil of the Pernambuco state; Avaliacao dos processos oxidativos avancados num solo contaminado do estado de Pernambuco

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Paula T.S. e [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Quimica; Santos, Suenia S. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Engenharia Quimica; Barros Neto, Benicio de [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Quimica Fundamental; Dorea, Haroldo S. [Universidade Federal de Sergipe (UFS), Aracaju, SE (Brazil); Motta Sobrinho, Mauricio A. da; Silva, Valdinete L. da [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

    2004-07-01

    In this work were used the following techniques of advanced oxidative processes: hydrogen peroxide, Fenton reagent and heterogeneous photocatalysis (TiO2). These processes have shown as an alternative technology to the treatment of some environmental matrices. The soil studied was contaminated by an oil mixture proceeding from an emptying in the patio of an industry of the state of Pernambuco. This soil has about 14,5 g/Kg of total organic carbon and 3400 mg/kg of TPH. Two planning factorial 23 were composed: one in relation to hydrogen peroxide and the other to titanium dioxide, in order to find the best conditions for the contaminant degradation. The variables and the studied levels for the former was: FeSO4 - 0,18 M (without, 4 and 8 ml); Adjustment of pH (3, without, without); Time of exposition to the sun (8h, 12h, 16h). The volumes of used peroxide in the assays were 80 and 40 ml. In relation to the second planning, were studied the following conditions: TiO2 (g) (without,5;0,75;1,0), volume H2O (0, 2,5 and 5 ml) and time of exposition to the sun (8, 40, 72h). In relation to the first planning a destruction of 84% of the oil was achieved. However, in relation to 2nd the planning non-significant degradation was obtained, and to study other conditions ought to be investigated. (author)

  12. Evaluation of the impacts of the gas aid program in Sao Paulo state, Brazil; Avaliacao dos impactos do programa do auxilio-gas no estado de Sao Paulo

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Thiago Pamplona [Universidade de Sao Paulo (FEARP-USP), Ribeirao Preto, SP (Brazil). Fac. de Economia, Administracao e Contabilidade; Anuatti Neto, Francisco [Universidade de Sao Paulo (PIPGE/USP), SP (Brazil). Programa Interunidades de Pos-Graduacao em Energia

    2008-07-01

    The objective of this article is to evaluate the coverage and the economic impact of the Federal Government Program Aid Gas (Auxilio Gas) , started in the year of 2002. The evaluation covers only the state of Sao Paulo, using as source the Research of Familiar Budgets of IBGE 2002/2003. To evaluate the coverage of 'Aid-Gas' the targeted population is compared with the population that effectively received the benefit. To evaluate the economic impact of the program a test of significance of dummy variable that differentiate weight gas consumption on income for those attended by the program, controlled by Working-Leser function that models the covariates of gas expenses. A low coverage of the program was evidenced, only 32,098 families had received the benefit (4,01%) out of 786.929 families targeted group, those with per capita income was inferior the half minimum wage. The economic impact had mixed results. In one hand program beneficiaries would spend a larger percentage of income with gas consumption than those not reached; on the other hand, they would have access larger quantities of the product. If the food consumption and the gas consumption are correlated, and the families not benefited by the program are rationed, it is possible to confirm that the introduction of the program would increase welfare of families. (author)

  13. Importance of evaluation of uncertainties on the measurement of natural gas and petroleum volumes; Importancia da avaliacao das incertezas na medicao dos volumes de petroleo e gas natural

    Energy Technology Data Exchange (ETDEWEB)

    Silva Filho, Jose Alberto Pinheiro da; Oliveira, Thiago Barra Vidal de; Mata, Josaphat Dias da [PETROBRAS, Rio de Janeiro, RJ (Brazil)], Emails: jose.pinheiro@petrobras.com.br, thiagovidal@petrobras.com.br, josaphat@petrobras.com.br; Val, Luiz Gustavo do [Instituto de Qualidade e Metrologia (IQM), Rio de Janeiro, RJ (Brazil)], E-mail: gdoval.iqm@petrobras.com.br

    2009-07-01

    The measurement is considered as the 'cash register' of the enterprises, increasing the accuracy and the exigence at each step when come close to the delivery points, where the 0.1 % of differences are discussed. The work presents the approach used in the evaluation of measurement uncertainties in the volumes obtained of petroleum and natural gas at the processes of production in Brazil, and in the international level as well.

  14. An evaluation of the potential impacts of the 'gas aid'; Uma avaliacao dos impactos potenciais do 'auxilio gas'

    Energy Technology Data Exchange (ETDEWEB)

    Biazotto, Ana Lidia; Anuatti Neto, Francisco [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Economia, Administracao e Contabilidade

    2004-07-01

    In May of 2001, the prices to the final consumer of GLP were set free in the whole country; this procedure had the intention, to continue process of deregulation in the fuel sector, in accord with the Oil Law. The release of the prices of sale and shipping subsidies elimination, along with the elimination of the crossed subsidy, required the adoption of a 'gas aid' social program, aimed to guarantee the low profit families necessities attendance that would pay the additional fuel costs. The objective of this paper is to evaluate the gas aid program as its covering level and the economic and distributive efficiency. The study encloses the metropolitans regions investigated in the IBGE Family Budget Research of 1996. With base in the previously identification of the potential beneficiary of the program, and with them consumption profile, it was possible to evaluate the potential impact of the withdrawal of the subsidy in the hypothesis of the family be or not beneficiary of the program. Assuming that the targeting is perfect, it is compared the transference politics to the low profit families in relation to the previous politics of subsidize crossed. (author)

  15. Situational quality evaluation of mammography services at state of Minas Gerais, Brazil; Avaliacao situacional da qualidade dos servicos de mamografia do estado de Minas Gerais, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Joana, Georgia S.; Oliveira, Mauricio de; Andrade, Mauricio C. de; Cesar, Adriana C.Z., E-mail: georgia.santos@saude.mg.gov.b, E-mail: mauricio.cavalcanti@saude.mg.gov.b, E-mail: adrianac@saude.mg.gov.b, E-mail: mauricio.oliveira@saude.mg.gov.b [Secretaria de Estado da Saude de Minas Gerais (SVS/SES-MG), Belo Horizonte, MG (Brazil). Superintendencia de Vigilancia Sanitaria; Oliveira, Marcio A.; Nogueira, Maria do S., E-mail: marcio.alves@saude.mg.gov.b, E-mail: mnogue@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Peixoto, Joao E. [Instituto Nacional de Cancer (INCA), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    Breast cancer is the leading cause of cancer deaths in women. Currently, the most effective method for early detection of this cancer is the mammography, and to achieve the standard definition and contrast, the whole system of imaging must operate under optimal conditions. This paper presents the results of the assessment of mammography centers in the state of Minas Gerais, which was held with the aim of supporting the actions of the State Program of Quality Control in Mammography. These results indicated that less than half of mammography achieved the minimum standard of image quality, endorsing the need of a monitoring more efficient and effective, which led to the establishment, in Minas Gerais, of the monthly monitoring of image quality in mammography. (author)

  16. Occupational exposure prevention program to oil and gas industry; Antecipacao, reconhecimento, avaliacao e controle dos riscos ambientais em uma planta de petroleo e gas

    Energy Technology Data Exchange (ETDEWEB)

    Moraes, Paulo Sergio de [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Palierini, Renato Martins [TWA Brasil, Sao Caetano do Sul, SP (Brazil)

    2005-07-01

    PETROBRAS/TRANSPETRO Pipelines and Terminals have 500 regular employees and 5.064 out sourced workers in its Southeast Division. The out sourced employees work under 125 contracts involving a wide range of activities such as maintenance, pipeline operation, pipeline launching, engineering, administrative and auxiliary services. Among these workers, 1.200 peoples are subjected to occupational exposure, which may be present in the industrial process or in the products transported in our pipelines, e.g. industrial noise, sulfidric gas, toluene, xylene and benzene (recognized as a carcinogen according to ACGIH and Brazilian Ministry of Labour). Our PPRA (acronym in Portuguese for Occupational Exposure Prevention Program) involves the workforce and fosters health by anticipation, recognition, evaluation and control of the situations that may result in injuries. Further actions include the procurement of equipment for detection of these agents not only in the air but also diluted in liquids and the introduction of state-of the- art technologies for a better process control. The priority is the acquisition of equipment for collective protection not forgetting the individual protection equipment (IPE) and the required training. Implementation of this program counted on the effective involvement of the managers, contract supervisors and HSE professionals whose main task was to advise all involved parts on the use the Risk Analysis Methods tailored for Occupational Hygiene. Furthermore, these information will be used in a info system called SD-2000 that will gather and compare Health, Hygiene e Human Resources data in order to support the professional in the management and decision making process. (author)

  17. Evaluation by instrumented indentation of the damage caused by gamma radiation on polymeric materials; Avaliacao por indentacao instrumentada dos danos causados pela radiacao gama em materiais polimericos

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, M.P.; Azevedo, E.C.; Miquelin, C.A.; Soboll, D.S., E-mail: helunica@yahoo.com.b [Universidade Tecnologica Federal do Parana (DAFIS/UTFPR), Curitiba, PR (Brazil). Dept. Academico de Fisica

    2010-07-01

    Several materials with densities close to water are used as phantoms in dosimetry. Such materials are damaged because they are exposed to radiation, the surface layers suffer the largest changes. This damage can be assessed by instrumented indentation. This paper investigates the variations in hardness and elastic modulus of samples of polymethyl-methacrylate, polyvinyl chloride, polyacetal and polypropylene before and after being irradiated with gamma radiation dose 500 Gy, using a Nanoindeter XP, with applied loads between 1 mN and 400 mN. The results are discussed correlating the variations in the mechanical properties of polymers with their applications. (author)

  18. Evaluation of imaging methods in the diagnosis of urolithiasis: review of the literature; Avaliacao dos metodos de imagem no diagnostico da urolitiase: revisao da literatura

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Ricardo Miguel Costa de; Silva, Luciana Costa; Santos, Jovita Lane Soares; Tavares Junior, Wilson Campos [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Hospital das Clinicas. Servico de Radiologia e Diagnostico por Imagem]. E-mail: rmcfreitas@ig.com.br

    2004-08-01

    The aim of this study is to compare helical computed tomography with imaging studies currently used to evaluate patients with acute low back pain. In addition, we briefly review the pathophysiology of urolithiasis. The literature published in the last 30 years was reviewed, and the following methods were discussed: plain abdominal radiographs, intravenous pyelography, ultrasound of the urinary tract, and helical computed tomography. Helical computed tomography showed high sensitivity and specificity for detecting urolithiasis, virtually showing all stones, except in patients receiving indinavir. The accuracy of plain abdominal radiographs associated with ultrasound was similar to helical computed tomography, although the latter showed superiority as an isolated method. Data from literature suggest that whenever helical computed tomography is available, it is helpful in the evaluation of low back pain and also allows differential diagnosis between conditions that mimic the symptoms of urolithiasis.(author)

  19. Brain Tumors

    Science.gov (United States)

    A brain tumor is a growth of abnormal cells in the tissues of the brain. Brain tumors can be benign, with no cancer cells, ... cancer cells that grow quickly. Some are primary brain tumors, which start in the brain. Others are ...

  20. Urogenital tumors

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1994-03-01

    An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

  1. Odontogenic Tumors

    OpenAIRE

    TAHSİNOĞLU, Melih

    2013-01-01

    DefinitionThe neoplasms that consist of the cells considered specialized for odontogenesis, and their product (dentin, enamel, cementum) are called odontogenic tumors.ClassificationTo initiate odontogenesis, epithelium is a must. Same rule holds for the odontogenic tumors: without odontogenic epithelium, odontogenic tumors cannot be, without the induction of odontogenic epithelium odontogenic mesenchyme cannot develop.

  2. Tumor Markers

    Science.gov (United States)

    ... guidelines on a variety of topics, including tumor markers for breast cancer, colorectal cancer, lung cancer, and others. The ... of recurrence 70-Gene signature (Mammaprint®) Cancer type: Breast ... Can tumor markers be used in cancer screening? Because tumor markers ...

  3. Dos chalets, en Suecia

    Directory of Open Access Journals (Sweden)

    Erskine, Ralph

    1968-04-01

    Full Text Available Villa Engström, at Sorunda This house, of semi-spheric shape, has besically only one floor level, without basement. However, the guest room and the attic are a kind of second floor within the cupula. This is an experiment, with a view to the possible mass construction of this prototype. The various rooms are grouped in two blocks, one comprising the bedrooms, which are cellular type and of minimum size, and the bathrooms; the other includes the children's room, a living room which extends into the vestibule, and guest room at a higher level. Villa Ström, near Stockholm This house is practically cube shaped, with ample terraces, which are structurally independent of the central volume. A principal aim has been to obtain fine views in all directions, and also to take advantage of the ground slope. This house, of original and competent design, includes indoor gardens which add colour and life to the rooms.Villa Engström, en Sorunda Esta vivienda, que presenta una «forma» semiesferica, es fundamentalmente un edificio de una sola planta, sin sótano; sin embargo, el cuarto de huéspedes y el «ático» forman como una especie de doble planta dentro de la cúpula. Se trata de una experiencia con vistas a una posible fabricación en serie. Las diferentes habitaciones se hallan agrupadas en dos bloques: uno de ellos ocupado por los dormitorios —que son de tipo celular y de tamaño mínimo—, y los cuartos de baño; y el otro que comprende un cuarto para los niños, la sala de estar —unida con el vestíbulo—, y la habitación de los huéspedes en la parte superior. Villa Ström, cerca de Estocolmo La casa es prácticamente un cubo, con terrazas amplias e independientes estructuralmente del volumen principal. En todo caso, ha dominado la doble preocupación de conseguir magníficas vistas hacia todos los alrededores y una adaptación total a la pendiente del terreno. La vivienda se ha resuelto con maestría y originalidad, procurando zonas

  4. Differences in absorbed doses at risk organs and target tumoral of planning(PTV) in lung treatments using two algorithms of different calculations; Diferencias en las dosis absorbidas en organos de riesgo y volumen tumoral de planificacion (PTV) en tratamientos de pulmon usando dos algoritmos de calculo diferentes: pencil beam y collpased cone

    Energy Technology Data Exchange (ETDEWEB)

    Uruena Llinares, A.; Santos Rubio, A.; Luis Simon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.

    2006-07-01

    The objective of this paper is to compare, in thirty treatments for lung cancer,the absorbed doses at risk organs and target volumes obtained between the two used algorithms of calculation of our treatment planning system Oncentra Masterplan, that is, Pencil Beams vs Collapsed Cone. For it we use a set of measured indicators (D1 and D99 of tumor volume, V20 of lung, homogeneity index defined as (D5-D95)/D prescribed, and others). Analysing the dta, making a descriptor analysis of the results, and applying the non parametric test of the ranks with sign of Wilcoxon we find that the use of Pencil Beam algorithm underestimates the dose in the zone of the PTV including regions of low density as well as the values of maximum dose in spine cord. So, we conclude that in those treatments in which the spine dose is near the maximum permissible limit or those in which the PTV it includes a zone with pulmonary tissue must be used the Collapse Cone algorithm systematically and in any case an analysis must become to choose between time and precision in the calculation for both algorithms. (Authors)

  5. Evaluation of radiotherapy and chemotherapy treatment in patients of oral squamous cell carcinoma; Avaliacao dos resultados dos tratamentos radioterapico e quimioterapico em pacientes portadores de carcinoma espinocelular na cavidade bucal

    Energy Technology Data Exchange (ETDEWEB)

    Sannomiya, Eduardo Kazuo [Universidade de Santo Amaro (UNISA), SP (Brazil). Faculdade de Odontologia. Dept. de Diagnostico e Cirurgia; Medici Filho, Edmundo; Moraes, Luiz Cesar de; Castilho, Julio Cezar de Melo [UNESP, Sao Jose dos Campos, SP (Brazil). Faculdade de Odontologia. Dept. de Cirurgia, Periodontia e Radiologia; Furukawa, Souhei [Osaka Univ. (Japan). Faculdade de Odontologia. Dept. de Radiologia e Radioterapia Buco-Maxilo-Facial

    2003-12-01

    We evaluated the effectiveness of radiotherapy combined with chemotherapy in patients with oral squamous cell carcinoma. Therefore, 1042 cases where reviewed in School Dentistry - Osaka Univ. Seven hundred and fifteen were male and three hundred and twenty-seven were female. Ora cancer was affected more male than female patients, with mean age of 582 years old. The tongue was the most common anatomic localization of oral cancer. In tongue, the use of external radiotherapy y combined with brachytherapy and brachytherapy isolated presented better results than chemotherapy combined with external radiotherapy. In buccal mucosa, there was not differences in the treatment's results using external radiotherapy and combined chemotherapy and external radiotherapy. In tongue's floor and upper and jaw gingiva the combined treatment with chemotherapy and external radiotherapy presented better results than isolated external radiotherapy. (author)

  6. Imunolocalização das proteínas dos genes supressores de tumores TP53 e p16CDKN2 no front invasivo do carcinoma epidermóide de cavidade bucal Immunolocalization of TP53 and p16CDKN2 tumour suppressor genes proteins in invasive front of oral epidermoid carcinoma

    Directory of Open Access Journals (Sweden)

    Alfredo Maurício Batista De-Paula

    2006-08-01

    Full Text Available INTRODUÇÃO: A carcinogênese bucal é um processo multipassos no qual eventos genéticos promovem o rompimento de vias regulatórias normais que controlam funções celulares básicas. O carcinoma epidermóide de cavidade bucal (CECB surge como conseqüência de múltiplos eventos moleculares induzidos pelos efeitos de vários carcinógenos influenciados por fatores ambientais contra um quadro de resistência ou suscetibilidade herdada geneticamente. OBJETIVO: Avaliar a importância clínica e morfológica da imunoexpressão das proteínas p53 e p16 na região do front invasivo de uma série de 35 casos rotineiramente processados de CECB. MATERIAL E MÉTODOS: Amostras de CECB primários tratados exclusivamente por cirurgia foram investigadas. O sistema TNM foi empregado para o estadiamento clínico dos pacientes. Para a gradação morfológica das lesões foi adotado o sistema de gradação do front invasivo. A técnica de imuno-histoquímica foi realizada nas lesões fixadas em formalina tamponada a 10% e emblocadas em parafina para identificação das proteínas p53 e p16. As contagens foram realizadas e submetidas a tratamentos estatísticos específicos. RESULTADOS: As taxas de imunolocalização para as proteínas p53 e p16 foram de 63% e 66%, respectivamente, nas 35 amostras de carcinoma estudadas. Não houve relação entre as expressões das proteínas p53 e p16 com os parâmetros clínico-morfológicos analisados. Não houve correlação entre a expressão imuno-histoquímica das proteínas p53/p16. CONCLUSÃO: A expressão das proteínas p53 e p16 não influenciou os parâmetros clínico-morfológicos analisados neste estudo e aparentemente não representa base molecular para o significado biológico da região do front invasivo tumoral. A ausência de forte correlação entre as expressões imuno-histoquímicas das proteínas p53 e p16 sugere que as mesmas podem participar de atividade biológicas do controle do ciclo celular por

  7. A epilepsia nos tumores cerebrais

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1969-03-01

    Full Text Available De 411 casos de tumores cerebrais foram estudados 86 (19,4% que apresentaram manifestações epilépticas. A epilepsia foi estudada quanto à duração, ao tipo de manifestação e à severidade, em relação à natureza e à localização dos tumores cerebrais. A análise dos resultados permitiu aos autores chegarem às seguintes conclusões: 1 a epilepsia incidiu em 19,4% dos casos; 2 o oligodendroglioma, as metástases carcinomatosas e o glioblastoma multiforme foram, pela ordem, os tumores mais epileptogênicos; 3 as áreas frontal, parietal e temporal foram, nessa ordem, as localizações mais epileptogênicas; 4 os carcinomas metastáticos predominaram nos casos com epilepsia com menos de um ano de evolução, enquanto que os astrocitomas predominaram nos casos com mais de três anos; quanto à topografia, predominou a região frontal no primeiro grupo e a temporal, no segundo; 5 nas formas mais severas de epilepsia predominaram os oligodendrogliomas e os meningeomas, quanto à natureza, e a região frontotemporal e a foice, quanto à localização; 6 os craniofaringeomas e os meduloblastomas foram os tumores que mais freqüentemente determinaram o aparecimento de convulsões puras; nesses casos, a sela túrsica e a fossa posterior foram as sedes mais freqüentes; 7 os carcinomas metastáticos e os meningeomas, quanto à natureza, e as regiões frontoparietal e parietal, quanto à localização, foram os mais freqüentemente encontrados nos casos com crises de tipo bravais-jacksoniano.

  8. Instrumentos em Lingua Brasileira de Sinais para avaliacao da qualidade de vida da populacao surda

    Directory of Open Access Journals (Sweden)

    Neuma Chaveiro

    2013-06-01

    Full Text Available OBJETIVO: Construir a versão em Língua Brasileira de Sinais dos instrumentos WHOQOL-BREF e WHOQOL-DIS para avaliar a qualidade de vida da população surda brasileira. MÉTODOS: Utilizou-se metodologia proposta pela Organização Mundial da Saúde (WHOQOL-BREF e WHOQOL-DIS para a construção dos instrumentos adaptados para população surda em Língua Brasileira de Sinais (Libras. A pesquisa para execução do instrumento consistiu de 13 etapas: 1 criação do sinal qualidade de vida; 2 desenvolvimento das escalas de respostas em Libras; 3 tradução por um grupo bilíngue; 4 versão reconciliadora; 5 primeira retrotradução; 6 produção da versão em Libras a ser disponibilizada aos grupos focais; 7 realização dos grupos focais; 8 revisão por um grupo monolíngue; 9 revisão pelo grupo bilíngue; 10 análise sintática/semântica e segunda retrotradução; 11 reavaliação da retrotradução pelo grupo bilíngue; 12 filmagem da versão para o software; 13 desenvolvimento do software WHOQOL-BREF e WHOQOL-DIS em Libras. RESULTADOS: Características peculiares da cultura da população surda apontaram a necessidade de adaptações na metodologia de aplicação de grupos focais quando compostos por pessoas surdas. As convenções ortográficas da escrita das línguas sinalizadas não estão consolidadas, o que trouxe dificuldades em registrar graficamente as etapas de tradução. As estruturas linguísticas que causaram maiores problemas de tradução foram as que incluíram expressões idiomáticas do português, muitas sem conceitos equivalentes entre o português e a Libras. Foi possível construir um software do WHOQOL-BREF e WHOQOL-DIS em Libras. CONCLUSÕES: O WHOQOL-BREF e o WHOQOL-DIS em Libras possibilitarão que os surdos se expressem autonomamente quanto a sua qualidade de vida, o que permitirá investigar com maior precisão essas questões.

  9. Sobre a psicopatologia dos atos

    Directory of Open Access Journals (Sweden)

    Roberto Calazans

    2015-07-01

    Full Text Available Este artigo pretende apresentar a psicopatologia dos atos a partir do esquema de Jacques Lacan sobre a angústia. Diferenciamos os acting-out, a passagem ao ato, os sintomas, as inibições e a angústia fazendo uma duplicação do esquema de Lacan levando em consideração os registros do simbólico, do real e do imaginário. Esse esquema permite uma abordagem da questão dos atos do sujeito sem cair em uma perplexidade do clínico, nem na confusão entre os atos e a ação. Permite também uma melhor orientação do clínico em relação às diversas modalidades de respostas subjetivas que não se restringem à questão sintomática, que é o campo inaugural da clínica psicanalítica desde a sua fundação por Sigmund Freud. Acreditamos contribuir, assim, para um maior esclarecimento desse esquema no ensino de Lacan e para que ele possa servir de orientação para o tratamento dos atos do sujeito na clínica.

  10. Imaging of brain tumors

    International Nuclear Information System (INIS)

    The contents are diagnostic approaches, general features of tumors -hydrocephalus, edema, attenuation and/or intensity value, hemorrhage, fat, contrast enhancement, intra-axial supratentorial tumors - tumors of glial origin, oligodendrogliomas, ependymomas, subependymomas, subependymal giant cell astrocytomas, choroid plexus papilloma; midline tumors - colloid cysts, craniopharyngiomas; pineal region tumors and miscellaneous tumors i.e. primary intracerebral lymphoma, primitive neuroectodermal tumors, hemangioblastomas; extraaxial tumors - meningiomas; nerve sheath tumors -schwannomas, epidermoids, dermoids, lipomas, arachnoid cysts; metastatic tumors (8 refs.)

  11. Testicular tumors

    Directory of Open Access Journals (Sweden)

    Giovanni Rosti

    2011-12-01

    Full Text Available Germ cell tumors of the testes represent a unique paradigm of diseases which can be cured even in extremely advanced phase. Unfortunately, this makes them unique among adult solid tumors. Seminoma and non seminoma are relatively rare with approximatively 25,000 patients in Europe per year, but numbers are increasing world wide. Different strategies are needed depending on stage and prognostic scores. Seminoma is extremely sensitive to radiation therapy and chemotherapy, while all germ cell tumors show a very good response to chemotherapy. Clinical stage I seminoma is currently treated with radiation, single course carboplatin or surveillance policy. Clinical stage I non seminoma can also be approached with different strategies such as retroperitoneal lymph node dissection, observation or one-two courses of standard chemotherapy. Stage II seminoma may be treated with either radiation or chemotherapy, while for all advanced stages chemotherapy is mandatory. Since the mid-eighties PEB (Cisplatin, Etoposide and Bleomycin is the regimen of choice and no other schedule has proved superior in terms of efficacy. Surgery on the residual disease is crucial to the whole strategy and should be performed or attempted in all cases. Consequently, the correct treatment strategy for these tumors does not depend only on the ability of a single physician, but on a skilled team specialized in this particular tumor. Second line therapies (VeIP, PEI, TIP can cure 25%–40% of patients, but improved strategies for resistant tumors are desperately needed. High-dose chemotherapy has shown very good results in some studies while being less impressive in others. In any case, it should remain an option for relapsing patients and could be used in some cases of upfront chemotherapy in patients with slow marker decline, but this should only be considered in referring centers.

  12. Superior sulcus tumors (Pancoast tumors).

    Science.gov (United States)

    Marulli, Giuseppe; Battistella, Lucia; Mammana, Marco; Calabrese, Francesca; Rea, Federico

    2016-06-01

    Superior Sulcus Tumors, frequently termed as Pancoast tumors, are a wide range of tumors invading the apical chest wall. Due to its localization in the apex of the lung, with the potential invasion of the lower part of the brachial plexus, first ribs, vertebrae, subclavian vessels or stellate ganglion, the superior sulcus tumors cause characteristic symptoms, like arm or shoulder pain or Horner's syndrome. The management of superior sulcus tumors has dramatically evolved over the past 50 years. Originally deemed universally fatal, in 1956, Shaw and Paulson introduced a new treatment paradigm with combined radiotherapy and surgery ensuring 5-year survival of approximately 30%. During the 1990s, following the need to improve systemic as well as local control, a trimodality approach including induction concurrent chemoradiotherapy followed by surgical resection was introduced, reaching 5-year survival rates up to 44% and becoming the standard of care. Many efforts have been persecuted, also, to obtain higher complete resection rates using appropriate surgical approaches and involving multidisciplinary team including spine surgeon or vascular surgeon. Other potential treatment options are under consideration like prophylactic cranial irradiation or the addition of other chemotherapy agents or biologic agents to the trimodality approach.

  13. Avaliacao da seguranca de diferentes doses de suplementos de acido folico em mulheres do Brasil

    Directory of Open Access Journals (Sweden)

    Quenia dos Santos

    2013-10-01

    Full Text Available OBJETIVO Avaliar a distribuição da ingestão de ácido fólico e a segurança de diferentes doses de suplementos em mulheres em idade reprodutiva. MÉTODOS Foram utilizados dados de consumo a partir de dois dias não consecutivos de registro alimentar de 6.837 mulheres em idade reprodutiva (19 a 40 anos participantes do Inquérito Nacional de Alimentação, módulo da Pesquisa de Orçamentos Familiares 2008-2009. Médias e percentis de consumo habitual de folato natural e ácido fólico foram estimados utilizando o método do National Cancer Institute . Cinco cenários foram simulados somando-se diferentes doses diárias de fortificação (400 mcg, 500 mcg, 600 mcg, 700 mcg e 800 mcg ao ácido fólico oriundo dos alimentos consumidos pelas mulheres. Comparou-se o total de ácido fólico (dieta + suplemento com o nível máximo de ingestão tolerável (UL = 1.000 mcg para definir a dose segura de suplementação. RESULTADOS Mulheres com ingestão habitual de ácido fólico acima do nível máximo de ingestão tolerável foram observadas para doses de suplemento de 800 mcg (7,0% das mulheres. Abaixo desse valor, qualquer dose de suplementação mostrou-se segura. CONCLUSÕES O uso de suplementos de até 700 mcg de ácido fólico mostrou-se seguro.

  14. Remessas de recursos dos imigrantes

    Directory of Open Access Journals (Sweden)

    Ana Cristina Braga Martes

    2006-08-01

    Full Text Available AS REMESSAS contribuem para o desenvolvimento local e para redução da pobreza? Essa é a pergunta-chave que os estudos recentes sobre migrações internacionais têm levantado. O que se está procurando compreender é de que modo as remessas poderiam afetar positiva ou negativamente a economia dos países de origem dos imigrantes. Discutir o papel e o significado das remessas implica, assim, uma discussão em torno da existência (ou não de um "campo de positividades" do fenômeno migratório internacional. O principal objetivo deste artigo é contribuir para essa discussão por meio de um estudo empírico do caso brasileiro que adota as remessas como foco. Para tanto, é identificado o perfil das remessas e dos remetentes, assim como os objetivos e os beneficiários do dinheiro enviado. A pesquisa usa uma abordagem baseada em entrevistas em profundidade e survey não-representativo (Boston e Governador Valadares.DO REMITTANCES contribute to local development and the reduction of poverty? What are the consequences of the dollars sent by the migrants to the people, families, and organizations that receive them in the cities of origin? These are the key questions that recent studies have raised. According to some authors "migration is inevitable and has the potential to be quite positive in terms of development and reduction of poverty. The policies that have their origins in this principle will be more successful than those that attempt to oppose, intransigently, both globalization and the migration of people in space". Do current international migrations produce positive local development effects? The main objective of this article is to contribute to this discussion through an empirical study of the Brazilian case, which takes remittances as its focus. Thus, we identify who the immigrants are who send remittances from the United States to Brazil, to what ends the remittances are directed, who the beneficiaries are, and how the remittances

  15. Avaliacao da Relacao entre a Doenca Hepatica Nao Gordurosa e CAD utilizando TCMF

    Directory of Open Access Journals (Sweden)

    Duran Efe

    2014-01-01

    Full Text Available Fundamento: Alguns fatores de risco para a aterosclerose são acompanhados pela doença hepática gordurosa não alcoólica (DHGNA. Desejamos usar a tomografia computadorizada multi-fatias (TCMF como a técnica para encontrar relação entre a DHGNA e a doença arterial coronariana (DAC. Objetivo: A relação entre a DHGNA e a DAC foi investigada através de TCMF. Métodos: Um total de 372 indivíduos com ou sem sintomas cardíacos, que foram submetidos à angiografia por TCMF, foram incluídos no estudo. Os pacientes foram divididos em dois grupos, de acordo com a presença da DHGNA. Os segmentos arteriais coronarianos foram avaliados visualmente via angiografia por TCMF. Com base no grau de estenose arterial coronariana, aqueles com placas ausentes ou mínimas foram considerados como normais, enquanto aqueles que apresentavam estenose de menos do que 50% e no mínimo uma placa foram considerados como portadores da doença arterial coronariana não obstrutiva (não-obsDAC. Os pacientes que apresentaram no mínimo uma placa e estenose arterial coronariana de 50% ou mais foram considerados como portadores de doença arterial coronariana obstrutiva (obsDAC. A DHGNA foi determinada de acordo com o protocolo de TCMF, utilizando a densidade hepática. Resultados: De acordo com a densidade hepática, o número de pacientes com doença hepática gordurosa não alcoólica (grupo 1 foi de 204 (149 homens, 54,8% e com fígado normal (grupos 2 foi de 168 (95 homens, 45.2%. Houve 50 (24,5% não-obsDAC e 57 (27,9% casos de obsDAC no Grupo 1, e 39 (23,2% não-obsDAC e 23 (13,7% casos de obsDAC no Grupo 2. Conclusões: O presente estudo utilizando TCMF demonstrou que a frequência da doença arterial coronariana em pacientes com NAFDL foi significativamente superior do que nos pacientes em NAFDL.

  16. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  17. Brain tumor - children

    Science.gov (United States)

    ... children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children) ... The cause of primary brain tumors is unknown. Primary brain tumors may ... (spread to nearby areas) Cancerous (malignant) Brain tumors ...

  18. perspectiva dos Enfermeiros de Psiquiatria

    OpenAIRE

    Silva, Marcelo Filipe Alves da

    2013-01-01

    Tem-se verificado, nas últimas décadas, um aumento da tentativa de suicido ao nível da população mundial, com números preocupantes no que concerne à prática ou tentativa de colocar um fim à própria vida. A enfermagem na área da Psiquiatria, num contexto multidisciplinar, quer ao nível clínico, quer hospitalar, surge como uma via importante de prevenção, identificação e encaminhamento dos pacientes que, por diversos motivos, possam proceder ao suicídio, ou pelo menos à sua tentativa. Per...

  19. Pediatric brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Poussaint, Tina Y. [Department of Radiology, Boston, MA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Huisman, Thierry A.G.M. [Charlotte R. Bloomberg Children' s Center, Johns Hopkins Hospital, Division of Pediatric Radiology and Pediatric Neuroradiology, Baltimore, MD (United States)

    2015-09-15

    Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics. (orig.)

  20. Teratoid Wilms′ tumor - A rare renal tumor

    Directory of Open Access Journals (Sweden)

    Biswanath Mukhopadhyay

    2011-01-01

    Full Text Available Teratoid Wilms′ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms′ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy was done and the patient had an uneventful recovery. Histopathology report showed teratoid Wilms′ tumor.

  1. [Tumor surgery].

    Science.gov (United States)

    Hausamen, J E

    2000-05-01

    Surgery is still the primary therapeutic approach in treatment of tumors in the head and neck area, dating back to the early nineteenth century. More than 150 years ago, hemimaxillectomies and mandibular resections as well as hemiglossectomies were already performed by leading surgeons. The block principle we are now following dates back to Crile, who also established the principle of cervical lymph node dissection. Ablative oncologic surgery has always been closely linked with plastic and reconstructive surgery, rendering radical surgical interventions possible without disfiguring patients. The development of facial reconstructive surgery proceeded in stages, in the first instance as secondary reconstruction using tube pedicled flaps. The change to the concept of primary reconstruction occurred via arterialized skin flaps and myocutaneous flaps to the widely accepted and performed free tissue transfer. Free bone grafting, inaugurated earlier and still representing the majority of bone grafting, has been supplemented for certain reconstructive purposes by free vascularized bone transfer from various donor sites. Although the five-year-survival rate of carcinoma of the oral cavity has remained unchanged in the past 30 years, distinctive improvements in tumor surgery can be recorded. This is primarily based on improved diagnostics such as modern imaging techniques and the refinement of surgical techniques. The DOSAK has worked out distinctive guidelines for effective ablative oncologic surgery. Surgical approaches offering wide exposure and carrying low morbidity play a decisive role in radical resections. For this reason, midfacial degloving offers an essential improvement for the resection of midface tumors, especially from an aesthetic point of view. Tumors situated deep behind the viscerocranium at the skull base can be clearly exposed either through a lateral approach following a temporary osteotomy of the mandibular ramus or a transmandibular, transmaxillar, or

  2. O Conceito Kantiano de Metafisica dos Costumes

    Directory of Open Access Journals (Sweden)

    Joel Thiago Klein

    2009-06-01

    Full Text Available Neste texto reconstrói-se o conceito kantiano de metafísica dos costumes com o objetivo de apresentar claramente os seus aspectos essenciais, mas sem entrar em questões relativas a sua legitimidade. Nas primeiras duas partes do trabalho mostra-se como Kant reinterpreta a divisão geral da filosofia e como o conceito de uma metafísica dos costumes passa a ser visto a partir do empreendimento crítico-transcendental. Na terceira parte aponta-se para algumas nuances e ambigüidades do conceito de “Metafísica dos costumes”. Por fim, enumera-se os motivos teóricos e práticos a partir dos quais Kant defende a necessidade de uma Metafísica dos costumes.

  3. Classificação da Organização Mundial da Saúde para os tumores dos tecidos hematopoético e linfoide, 4ª edição, 2008: principais modificações introduzidas em relação à 3ª edição, 2001 World Health Organization classification of tumors of hematopoietic and lymphoid tissues, 4th edition, 2008: major changes from the 3rd edition, 2001

    Directory of Open Access Journals (Sweden)

    Maria Claudia Nogueira Zerbini

    2011-02-01

    Full Text Available A Classificação da Organização Mundial da Saúde (OMS para os tumores do tecido hematopoético e linfoide (4ª edição, 2008¹ representa uma atualização da 3ª edição, 2001². Apresentamos a seguir um resumo dessas alterações nos grupos das doenças mieloproliferativas, mileodisplásicas, leucemias mieloides agudas, neoplasias de células precursoras B e T, e neoplasias de células B, T e NK maduras. O entendimento das alterações genético-moleculares e os resultados alcançados com propostas terapêuticas inovadoras nesses grupos de doenças demandam constante reavaliação de sua classificação, justificando as alterações importantes aqui discutidas1,3-5.The World Health Organization (WHO Classification of tumors of hematopoietic and lymphoid tissues (4th edition, 2008¹ presents an updated version of the 3rd edition published in 2001². A summary of these changes relates to the groups of chronic myeloproliferative disorders, myelodisplasia, acute myeloid leukemias, neoplasms of precursor B and T cells and neoplasms derived of mature B, T and NK cells. A better understanding of molecular genetic changes and results achieved with innovative therapeutic approaches in these groups of diseases requires constant reassessment of the classifications, supporting the major changes discussed here, including interesting comments from literature1, 3-5.

  4. Aplicação clínica dos marcadores tumorais séricos em carcinoma não-pequenas células do pulmão Clinical application of serum tumor markers in patients with non-small cell lung carcinoma

    OpenAIRE

    JEFFERSON LUIZ GROSS; RIAD NAIM YOUNES; JOSÉ ALEXANDRE MARZAGÃO BARBUTO; FABIO JOSÉ HADDAD; DANIEL DEHENZELIN

    2000-01-01

    O valor clínico dos marcadores tumorais séricos em câncer de pulmão é incerto. Objetivos: Avaliar a associação da concentração sérica de marcadores tumorais com a extensão da neoplasia e seu valor prognóstico. Casuística e método: Entre fevereiro de 1995 e setembro de 1997 foram estudados 103 pacientes, no Departamento de Cirurgia Torácica do Hospital do Câncer. Antes do tratamento os pacientes foram submetidos à coleta de sangue para dosagem da concentração do CEA, CYFRA21.1, CA15.3, CA19.9,...

  5. Brain Tumors (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Brain Tumors KidsHealth > For Parents > Brain Tumors Print A ... radiation therapy or chemotherapy, or both. Types of Brain Tumors There are many different types of brain ...

  6. Childhood Brain Tumors

    Science.gov (United States)

    Brain tumors are abnormal growths inside the skull. They are among the most common types of childhood ... still be serious. Malignant tumors are cancerous. Childhood brain and spinal cord tumors can cause headaches and ...

  7. Tumors and Pregnancy

    Science.gov (United States)

    Tumors during pregnancy are rare, but they can happen. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. The most common cancers in pregnancy are breast cancer, cervical cancer, lymphoma, and melanoma. ...

  8. Neuroendocrine Tumor: Statistics

    Science.gov (United States)

    ... Tumor > Neuroendocrine Tumor - Statistics Request Permissions Neuroendocrine Tumor - Statistics Approved by the Cancer.Net Editorial Board , 04/ ... the body. It is important to remember that statistics on how many people survive this type of ...

  9. Tratamento atual dos miomas Current treatment of leiomyomas

    Directory of Open Access Journals (Sweden)

    Helena von Eye Corleta

    2007-06-01

    Full Text Available Leiomiomas são tumores benignos. Eles surgem no miométrio e contêm quantidade variável de tecido conjuntivo fibroso. Cerca de 75% dos casos são assintomáticos, encontrados ocasionalmente durante exame abdominal, pélvico bimanual ou ultra-sonografia. Os sintomas são relacionados diretamente ao tamanho, ao número e à localização dos miomas. Nessa revisão, são apresentadas as abordagens terapêuticas atuais clínicas (anticoncepcionais orais, progestágenos e antiprogestágenos, análogos do hormônio liberador das gonadotrofinas (GnRH, e antiinflamatórios não esteróides e cirúrgicas (histerectomia, miomectomia e embolização para o tratamento de leiomiomas.Leiomyomas are benign tumors. They appear in the myometrium and present a variable amount of fibrous conjunctive tissue. About 75% of the cases are not symptomatic and are usually found during abdominal, bimanual pelvic examination or during ultrasonography. The symptoms are directly related to the size, number and localization of the myomas. In the present review, the current clinical therapeutic procedures (oral anti-conceptive drugs, progestins and anti-progestins, analogues of the gonadothrophins’ releasing hormone (GnRH, and non-steroid anti-inflammatory drugs, and also the surgical procedures (hysterectomy, myomectomy, embolization are presented for the treatment of leiomyomas.

  10. Valor da ressonância magnética no planejamento radioterápico dos tumores de colo de útero: resultados preliminares Value of magnetic resonance imaging in the radiotherapy planning of tumours of the uterine cervix: preliminary results

    Directory of Open Access Journals (Sweden)

    Pitágoras Baskara Justino

    2005-12-01

    Full Text Available OBJETIVO: Verificar o índice de erros geográficos no planejamento radioterápico convencional de pacientes com carcinoma de colo uterino por meio da ressonância magnética. MATERIAIS E MÉTODOS: Trinta e duas pacientes com diagnóstico histológico de carcinoma espinocelular de colo uterino, com indicação de radioterapia, foram analisadas. Foi realizada ressonância magnética da pelve, sendo essas imagens comparadas aos campos clássicos de radioterapia, técnica de quatro campos em "tijolo". Considerou-se erro geográfico quando o volume alvo não foi englobado pelos campos, com margens mínimas de 1 cm. RESULTADOS: Em 24 pacientes (75% foi detectada possibilidade de erro geográfico se fossem utilizados os campos convencionais. Em todos os casos o erro foi à custa dos limites anterior (46% ou posterior (40% dos campos laterais. CONCLUSÃO: A ressonância magnética evidenciou chance elevada de erro geográfico no planejamento radioterápico convencional na população analisada, tanto nas pacientes com doença em estádios iniciais quanto avançados.OBJECTIVE: To assess the rate of geographic miss on conventional radiotherapy planning of patients with cervical cancer, using magnetic resonance imaging. MATERIALS AND METHODS: Thirty-two patients with squamous cell carcinoma of the uterine cervix were studied. Magnetic resonance imaging of the pelvis was performed after clinical staging. Magnetic resonance imaging findings were compared with the classic fields described for the "box" technique. Target volume within less than 1 cm margins of the fields' limits was considered as geographic miss. RESULTS: Classical radiation field limits were inadequate in 24 cases (75%, all in the anterior (46% or posterior (40% border of the lateral fields. CONCLUSION: Magnetic resonance detected a high probability of geographic miss on conventional radiotherapy planning in this population, both in initial and advanced stages of the disease.

  11. Leitura rapida do KDIGO 2012: Diretrizes para avaliacao e manuseio da doenca renal cronica na pratica clinica

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    Gianna Mastroianni Kirsztajn

    2014-03-01

    Full Text Available Os autores desta "leitura rápida" apresentam os dados que consideraram mais relevantes na versão 2012 do KDIGO referente à avaliação e manuseio da doença renal crônica. Não se trata da opinião dos autores, mas sim de uma apresentação mais concisa das diretrizes, que podem ser úteis na prática clínica.

  12. Comparação entre o pencil beam convolution algorithm e o analytical anisotropic algorithm em tumores de mama

    OpenAIRE

    Sá, Ana Cravo; Coelho, Carina Marques; Monsanto, Fátima

    2014-01-01

    Objectivo do estudo: comparar o desempenho dos algoritmos Pencil Beam Convolution (PBC) e do Analytical Anisotropic Algorithm (AAA) no planeamento do tratamento de tumores de mama com radioterapia conformacional a 3D.

  13. Updates in Orbital Tumors

    Institute of Scientific and Technical Information of China (English)

    Nila; F.Moeloek

    1993-01-01

    Orbital anatomy, the clinical features of orbital tumors, the recent development of the diagnosis and management of orbital tumors were described. The incidence of orbital tumors in Dr. Cipto Mangunkusumo Hospital in the past years were introduced. The principle of management of orbital tumors and their prognosis were discussed.

  14. BENEFÍCIOS DOS PARQUES URBANOS

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    Raphael Tavares Pacheco Martins

    2014-07-01

    Full Text Available Esta pesquisa teve como objetivo apresentar o tema e analisar os benefícios gerados pelos parques urbanos. Para a sua realização foi definido como zona de estudo a região norte do estado do Rio de Janeiro. Os outros objetivos foram a qualificação e a definição das funções do parque e a elucidação da sua contribuição para a melhoria da qualidade de vida. Além do lazer, outras funções socioambientais relevantes são desempenhadas pelos parques urbanos destacando-se a psicológica, a reconstrução da tranquilidade, a recomposição do temperamento, atenuante de ruídos e condicionador do microclima, impondo a sua inclusão no planejamento e nas políticas públicas das cidades. A pesquisa foi estruturada por um levantamento histórico e uma revisão bibliográfica. Um dos principais efeitos dos parques urbanos é a amenização climática, com contribuições positivas para o microclima local. No passar dos anos por conta dos grandes lucros as empresas privadas levaram o conjunto urbano para um crescimento desordenado e minimizando a função social dos parques urbanos, criando problemas sociais, esquecendo-se dos valores pessoais, históricos, culturais alem da dimensão sensorial e psicológica.

  15. Supratentorial tumors; Supratentorielle Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.; Dillmann, K.; Roth, C.; Backens, M.; Reith, W. [Universitaetsklinikum Saarland, Homburg (Germany). Klinik fuer Diagnostische und Interventionelle Neuroradiologie

    2007-06-15

    Magnetic resonance imaging is a routine diagnostic measure for a suspected intracerebral mass. Computed tomography is usually also indicated. Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location. This contribution discusses the symptoms and diagnostics for supratentorial tumors separated in relation to their intra- or extracranial location. Supratentorial tumors include astrocytoma, differentiated by their circumscribed and diffuse growth, ganglioglioma, ependyoma, neurocytoma, primitive neuroectodermal tumors (PNET), oligodendroglioma, dysembryoplastic neuroepithelial tumors (DNET), meningoangiomatosis, pineal tumors, hamartoma, lymphoma, craniopharyngeoma and metastases. The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma. The most common subforms, especially of astrocytoma, will also be presented. (orig.)

  16. Tumores em bovinos encontrados em abatedouros frigoríficos

    Directory of Open Access Journals (Sweden)

    Bianca Tessele

    2016-03-01

    Full Text Available Resumo: Numa pesquisa em abatedouros a procura de lesões em bovinos, realizada de janeiro de 2011 a julho de 2014, 544 foram encontradas, das quais 65 eram neoplasmas. Quarenta e dois porcento desses tumores eram de origem mesenquimal; 37% eram epiteliais; 14,5% eram derivados da crista neural; 5% eram tumores do cordão sexual; e 1,5 eram tumores originários do sistema nervoso periférico. O tumor mais frequentemente encontrado foi o linfoma (28% de todos os tumores, a maioria dos casos como parte do complexo leucose bovina enzoótica. O carcinoma de células escamosas foi o segundo tumor mais frequente (15% de todos os tumores. É chamada a atenção para a frequência desses tumores e para a sua importância no diagnóstico diferencial no abatedouro frigorífico entre eles e outras lesões importantes, incluindo as lesões granulomatosas da tuberculose. Houve uma ocorrência significativa do feocromocitoma adrenal (13% de todos os tumores. Papilomatose representou apenas 3% de todos os tumores. Como papilomas são comuns em bovinos, seu baixo número nesse estudo pode ser explicado pelo fato de que eles não são usualmente diagnosticados no exame post mortem (quando o couro já foi retirado da carcaça, mas sim no exame ante mortem, como ocorreu na maioria dos casos deste estudo. Tumores encontrados com menor frequência (cada um perfazendo entre 1.5 e 3% de todos os tumores incluíram adenocarcinoma apócrino misto da cauda, adenocarcinoma mamário, adenocarcinoma uterino, carcinoma de células renais, fibroma interdigital, hemangiossarcoma, leiomioma uterino, lipoma, lipossarcoma, mesotelioma, neurofibroma, tumor de células da granulosa, tumor estromal gastrointestinal, tumores hepáticos, tumores melanocíticos, e tumores pulmonares primários. Pretende-se que os resultados dessa pesquisa possam ajudar na identificação das lesões na inspeção oficial em matadouros frigoríficos.

  17. Imaging the Tumor Microenvironment

    OpenAIRE

    LeBleu, Valerie

    2015-01-01

    The tumor microenvironment is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the tumor microenvironment are under active development and currently used modalities and novel approaches are summarized here. Understanding the dynamic and evolving functions of the tumor microenvironment is critical to accurately inform imaging and clinical care of cancer. Novel insights into distinct roles of the tumor microenvironment...

  18. Tumor Lysis Syndrome in Primitive Neuroectodermal Tumor

    Directory of Open Access Journals (Sweden)

    Animesh Das

    2016-07-01

    Full Text Available Tumor lysis syndrome (TLS consists of a triad of hyperuricemia, hyperphosphatemia, and hyperkalemia along with secondary hypocalcemia. It results from the massive release of intracellular ions from chemosensitive tumor cell death. Hematological malignancies such as acute leukemia and non- Hodgkin lymphoma are considered high risk for developing TLS. Solid tumors are considered less likely to develop TLS. We herein report a case of primitive neuroectodermal tumor developing TLS within 24 h of starting chemotherapy. The child developed severe clinical TLS and could not be saved. We think solid tumors with large tumor load needs to be classified as high risk for development of TLS. Prophylactic use of hyperhydration and other medical measures to prevent TLS is warranted in such cases.

  19. Tumores colorretais hereditários Hereditary colorectal tumors

    Directory of Open Access Journals (Sweden)

    Benedito Mauro Rossi

    1998-08-01

    Full Text Available Cerca de 4% a 15% dos tumores colorretais são hereditários e divididos em dois grupos: polipose adenomatosa familiar (FAP e câncer colorretal hereditário sem polipose (HNPCC. Ambas são doenças autossômicas dominantes, com transmissão vertical, geração após geração, sem preferência por sexo. A FAP tem penetrância praticamente completa, caracterizada por mais de cem pólipos adenomatosos no intestino grosso, que aparecem em geral após a puberdade e se transformam em câncer em todos os casos não tratados, levando o paciente ao óbito em tomo dos 45 anos de idade. Manifestações extracolônicas são comuns, tais como: pólipos em estômago e duodeno, sarcomas abdominais, pigmentação de retina, osteomas, entre outras. A FAP é causada por mutação no gene APC, que está localizado no cromossomo 5q. Seu tratamento é basicamente cirúrgico, com retirada do intestino grosso, podendo-se preservar o reto, se este não apresentar muitos pólipos. O HNPCC tem penetrância em torno de 80% e não apresenta os pólipos benignos como na FAP, que permitem identificar pacientes com o fenótipo da doença. Geralmente, o diagnóstico da lesão colônica é realizado já na fase maligna, em torno dos 45 anos de idade, com preferência para o lado direito do cólon. Pode haver associação com tumores de endométrio na mulher, estômago, pâncreas, entre outros. É causada por mutação em genes de reparo do DNA (hMSH2, hMLH1, hPMS1, hPMS2, hMSH6/GTBP. A colectomia total deve ser realizada em pacientes com câncer de cólon e HNPCC. Se o tumor estiver localizado no reto, a proctocolectomia total pode ser uma opção. Em indivíduos portadores do defeito genético predisponente ao HNPCC, porém, assintomáticos, a indicação de cirurgias profiláticas é controversa. Atualmente, podem-se identificar indivíduos portadores de defeito genético herdado tanto na FAP como no HNPCC. Esses testes baseiam-se no estudo direto dos genes respons

  20. Manual dos chefes de missão dos CONs: Rio 2016 : Abril 2016

    OpenAIRE

    2016-01-01

    Publicado em abril de 2016, o « Manual dos chefes de missão » oferece aos CONs uma visão detalhada dos serviços disponíveis durante os Jogos Olímpicos Rio 2016, assim como das operações durante os Jogos.

  1. Contabilidade criativa e responsabilidade dos auditores

    OpenAIRE

    Ariovaldo dos Santos; Ivan Ricardo Guevara Grateron

    2003-01-01

    Nos contextos nacional e internacional da profissão contábil, o auditor tem exercido um papel fundamental. A atividade profissional do auditor independente tem ajudado a impulsionar o desenvolvimento dos mercados, além de contribuir para o estabelecimento da ordem socioeconômica mundial. Na visão dos usuários externos da informação contábil, e dos próprios clientes, a atuação do auditor é sinônimo de confiança e credibilidade. Nos últimos meses, a onda de escândalos contábeis, com grandes emp...

  2. Evaluation of doses from radiodiagnostic procedures performed in veterinary medicine and assessing of the doses of secondary radiation in the medical staff and animal owners; Avaliacao das doses resultantes de procedimentos radiodiagnosticos realizados em medicina veterinaria e avaliacao das doses secundarias de radiacao espalhada no corpo clinico e nos proprietarios dos animais

    Energy Technology Data Exchange (ETDEWEB)

    Veneziani, Glauco Rogerio

    2012-07-01

    The primary goal in veterinary radiography is to produce radiographs of diagnostic quality on the first attempt. This goal serves three purposes: (1) to decrease radiation exposure to the patient and veterinary personnel; (2) to decrease the cost of the study for the client; and (3) to produce diagnostic data for rapid interpretation and treatment of the patient. This work aimed to determine the doses in dogs submitted to chest and abdomen X rays using the technique of thermoluminescence (TL) dosimetry. The radiation doses were assessed using thermoluminescent dosimeters of calcium sulphate doped with dysprosium (CaSO{sub 4}:Dy) and lithium fluoride doped with magnesium and titanium (LiF:Mg,Ti). The obtained results indicate that is extremely important the assessment of radiation doses involved in veterinary diagnostic radiology procedures, to evaluate the delivered doses to the animals, to be used as a parameter in the individual monitoring of pet's owners, who assist the animal positioning, and to protect occupationally exposed workers at the Veterinary Radiology Clinics. (author)

  3. La larga vida de dos rocas orensanas

    OpenAIRE

    García Quintela, Marco V.; Seoane-Veiga, Yolanda

    2011-01-01

    [ES] Se estudian dos rocas, un petroglifo y un «santuario rupestre » de la provincia de Ourense, con dos metodologías complementarias, la arqueología del paisaje y la «biografía» (Kopytoff) de los objetos. Partiendo de su descripción en textos cristianos se considera el patrón de localización que conforman en relación con castros importantes, relación que se propone fechar en la Edad del Hierro. Esta adscripción cronocultural y su posterior resemantización cristiana lleva a la consideración d...

  4. Conhecimento sobre sida e sexualidade dos adolescentes

    OpenAIRE

    Bento, Ermelinda Manuela Teixeira; Ferreira, Manuela Maria Conceição; Chaves, Cláudia Margarida Correia Balula; Duarte, João Carvalho

    2013-01-01

    A Síndrome de Imunodeficiência Adquirida (SIDA) assume-se como o mais grave problema de saúde pública da era moderna, apelidada pela OMS como a Primeira Crise Mundial da Saúde é uma doença que transpõe a sua índole de patologia do sistema imunitário anunciando-se como uma doença social, de índole comportamental que tem nos adolescentes um dos grupos de maior vulnerabilidade. De acordo com os dados da UNAIDS (2012), o grupo etário dos 15 aos 24 anos representa o agregado de maio...

  5. Synchronous subungual glomus tumors in the same finger Tumores glômicos subungueais sincrônicos no mesmo dedo

    OpenAIRE

    Nilton Di Chiacchio; Walter Refkalefsky Loureiro; Nilton Gioia Di Chiacchio; Diego Leonardo Bet

    2012-01-01

    The glomus tumor is an uncommon benign neoplasm of glomus cells. In the majority of the cases it is presented as a solitary painful papule in the subungual region. We report a rare case of a patient with two individual synchronous glomus tumors under the nail bed of the same finger.O tumor glômico é uma neoplasia benigna de células glômicas. Na maioria dos casos se apresenta como uma pápula solitária dolorosa na região subungueal. Relatamos o caso raro de um paciente com dois tumores glômicos...

  6. Modelo experimental de tumor de Walker Walker’s tumoral experimental model

    Directory of Open Access Journals (Sweden)

    Sandra Pedroso de Moraes

    2000-12-01

    Full Text Available Com o objetivo de padronizar normas técnicas para obtenção de modelo animal com tumor de Walker 256 e de estabelecer o número de células tumorais necessárias para que esse tumor tenha grande porcentagem de pega e longevidade, possibilitando o desenvolvimento de pesquisas em várias áreas da saúde, foi realizado trabalho em duas etapas. Na primeira foram utilizados 120 ratos para treinamento e definição da técnica. Na segunda etapa foram utilizados 84 ratos, sendo estes separados em 7 grupos (G de 12 animais cada. O tumor, na forma ascítica, foi inoculado no tecido celular subcutâneo do dorso dos ratos com os seguintes números de células: GI, 1 x 10(7; GII, 5 x 10(6; GIII, 2,5 x 10(6; GIV, 1 x 10(6; GV, 5 x 10(5; GVI, 3 x 10(5 e GVII, 2 x 10(5. Foram avaliadas a porcentagem de pega e a longevidade nos grupos. Os animais dos GI, GII, GIII e GIV obtiveram 100% de desenvolvimento tumoral, porém baixa longevidade. Os dos GV e GVI obtiveram desenvolvimento tumoral em frequência maior que 90% e longevidade satisfatória. Os do GVII não apresentaram desenvolvimento tumoral. Concluiu-se que todos os procedimentos devem ser exaustivamente treinados e que o número de células tumorais viáveis para inoculação, em tecido celular subcutâneo de ratos, deve estar na faixa entre 5 x 10(5 e 3 x 10(5.The aim of this work was standardize technical norms to obtain a model of Walker 256 tumor in animals and get the tumorous cells number needed to increase the tumorous join percentage and longevity, it makes possible the research development in several health areas. The work was realized in two stages. In first were used 120 rats to crew’s training and technicals definitions. In second stage were used 84 rats, these separated in 7 groups (G with 12 animals each one. The tumor, in ascitic form was inoculated on subcutaneous cellular tissue on dorsal of rats with the follow number of cells : GI, 1 x 10(7; GII, 5 x 10(6; GIII, 2,5 x 10(6; GIV, 1

  7. Evaluation of conformal radiotherapy techniques through physics and biologic criteria; Avaliacao de tecnicas radioterapicas conformacionais utilizando criterios fisicos e biologicos

    Energy Technology Data Exchange (ETDEWEB)

    Bloch, Jonatas Carrero

    2012-07-01

    In the fight against cancer, different irradiation techniques have been developed based on technological advances and aiming to optimize the elimination of tumor cells with the lowest damage to healthy tissues. The radiotherapy planning goal is to establish irradiation technical parameters in order to achieve the prescribed dose distribution over the treatment volumes. While dose prescription is based on radiosensitivity of the irradiated tissues, the physical calculations on treatment planning take into account dosimetric parameters related to the radiation beam and the physical characteristics of the irradiated tissues. To incorporate tissue's radiosensitivity into radiotherapy planning calculations can help particularize treatments and establish criteria to compare and elect radiation techniques, contributing to the tumor control and the success of the treatment. Accordingly, biological models of cellular response to radiation have to be well established. This work aimed to study the applicability of using biological models in radiotherapy planning calculations to aid evaluating radiotherapy techniques. Tumor control probability (TCP) was studied for two formulations of the linear-quadratic model, with and without repopulation, as a function of planning parameters, as dose per fraction, and of radiobiological parameters, as the α/β ratio. Besides, the usage of biological criteria to compare radiotherapy techniques was tested using a prostate planning simulated with Monte Carlo code PENELOPE. Afterwards, prostate planning for five patients from the Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, USP, using three different techniques were compared using the tumor control probability. In that order, dose matrices from the XiO treatment planning system were converted to TCP distributions and TCP-volume histograms. The studies performed allow the conclusions that radiobiological parameters can significantly influence tumor control

  8. Consistentie met MS-DOS software

    NARCIS (Netherlands)

    Olsthoorn TN

    1988-01-01

    Zonder de keuze van een zekere standaard-lijn ten aanzien van de software die men zelf gebruikt, kan nauwelijks efficient met een computer worden gewerkt. Onder UNIX en op de Macintosh is het gebruik van programma's en de uitwisseling van gegevens daartussen gestandaardiseerd. Onder MS-DOS

  9. A Teoria dos Conjuntos de Cantor

    Directory of Open Access Journals (Sweden)

    Antônio Acra Freiria

    1992-07-01

    Full Text Available No final dos anos 50 e começo doe anos 60, houve uma reformulação significativa da Matemática no Brasil. Sob a bandeira do modernismo, seus defensores buscaram inovações no ensino da Matemática. Dessa forma, os reformistas se concentraram essencialmente na linguagem abusiva e no formalismo da Teoria dos Conjuntos, o que trouxe mais danos do que benefícios do ensino da Matemática de 1º e 2ºgraus. A linguagem formal da Teoria dos Conjuntos é porém sua parte menos importante. A teoria criada por Cantor tão logo revelou-se como o fundamento de toda a Matemática, possibilitando o desenvolvimento de novas disciplinas, como a Topologia, a Algebra Abstrata, a Teoria da Medida e Integração, a Teoria da Probabilidade e a Análise Funcional. O objetivo deste trabalho é um relato sucinto de como surgiu essa teoria, apresentando o "Conjunto de Cantor" como um dos mais ricos exemplos de "Conjunto perfeito" encontrados na literatura matemática.

  10. Dos realizaciones prefabricadas en Bolonia/Italia

    Directory of Open Access Journals (Sweden)

    Salas, Julián

    1981-04-01

    Full Text Available Se describen dos obras realizadas mediante elementos prefabricados en Bolonia (Italia por la empresa Grandi Lavori. Se trata de un conjunto de tres grandes torres con proyecto del profesor Kenzo Tange y una construcción-piloto en el recinto ferial.

  11. PERFIL E EXPECTATIVAS DOS ALUNOS CONCLUINTES DOS CURSOS TECNICOS INTEGRADOS DO IFRN, CAMPUS APODI

    Directory of Open Access Journals (Sweden)

    Saara Ramila Gurgel de Oliveira

    2014-11-01

    Full Text Available Este trabalho teve por finalidade caracterizar o perfil e as expectativas dos alunos dos terceiros e quartos anos dos cursos técnicos integrado de Zootecnia e Biocombustíveis do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte – Campus Apodi. A pesquisa foi realizada com 138 alunos, através da aplicação de questionários com perguntas abertas e fechadas. A análise dos dados foi realizada de maneira descritiva e os mesmos apresentados em percentuais. Os principais resultados mostraram que as mulheres são maioria (60,9% e que a idade média foi de 17,4 anos. 99,3% dos alunos afirmaram querer cursar uma faculdade e a Universidade Federal do Rio Grande do Norte foi a instituição mais citada. Os cursos mais citados pelos discentes foram: Medicina, Ciência e tecnologia, Engenharia química, Engenharia civil, Direito e Medicina veterinária. Quanto a prática profissional, 89,9% dos alunos a realizam na forma de projetos de pesquisa ou extensão e 10,1% na forma de estágios. Mais de 97% dos estudantes estão satisfeitos com as disciplinas, porém 64,5% não estão satisfeitos com a quantidade de aulas práticas dos cursos. Quanto ao mercado de trabalho, 58,8% acreditam que há boas oportunidades. Dessa forma, conclui-se que são necessárias medidas para qualificar o ensino dos alunos, todavia, as mesmas dependem de uma gestão democrática que analise a opinião de toda a comunidade escolar.

  12. Pediatric Brain Tumor Foundation

    Science.gov (United States)

    ... you insights into your child's treatment. LEARN MORE Brain tumors and their treatment can be deadly so ... to make progress in “immunogenomics” Read more >> Pediatric Brain Tumor Foundation 302 Ridgefield Court, Asheville, NC 28806 ...

  13. Testicular germinal tumors

    International Nuclear Information System (INIS)

    This work is about diagnosis, treatment and monitoring of testicular germinal tumors. The presumed diagnosis is based in the anamnesis, clinical examination, testicular ultrasound and tumor markers. The definitive diagnosis is obtained through the inguinal radical orchidectomy

  14. Metaphyseal giant cell tumor

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, L.F.; Hemais, P.M.P.G.; Aymore, I.L.; Carmo, M.C.R. do; Cunha, M.E.P.R. da; Resende, C.M.C.

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed.

  15. Lung Carcinoid Tumor: Surgery

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » Surgery to treat lung carcinoid tumors Share this Page Close Push escape to close share window. Print ...

  16. Metaphyseal giant cell tumor

    International Nuclear Information System (INIS)

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed. (Author)

  17. Solubilidade e disponibilidade dos micronutrientes em fertilizantes

    Directory of Open Access Journals (Sweden)

    F. Vale

    1999-06-01

    Full Text Available A legislação brasileira exige que os micronutrientes nos fertilizantes sejam garantidos pelo teor total presente. Isto abre um precedente para a utilização de produtos não considerados como fontes de micronutrientes na fabricação dos fertilizantes. Todavia, a eficiência agronômica desses produtos é ainda duvidosa. Objetivou-se realizar um trabalho para caracterizar a solubilidade e a disponibilidade dos micronutrientes em trinta fertilizantes comerciais, por meio do uso de cinco extratores químicos: a água e soluções de ácido cítrico a 2%, de citrato neutro de amônio na diluição 1 + 9, de DTPA 0,005 mol L-1 e de EDTA 0,005 mol L-1. Os resultados mostraram a baixa solubilidade dos micronutrientes metálicos (cobre, ferro, manganês e zinco dos fertilizantes tipo "fritas". O ácido cítrico a 2% mostrou-se promissor na caracterização da disponibilidade de cobre, manganês e zinco para as plantas. Para o ferro não houve uma definição entre os extratores estudados. O boro teve boa solubilidade, tanto nos fertilizantes solúveis, como nos insolúveis em água, e a garantia pelo teor total mostrou-se bom indicativo da disponibilidade do elemento. Para o molibdênio a solubilidade foi maior para os fertilizantes com baixo teor do elemento. A garantia dos micronutrientes catiônicos pelo teor total, conforme exige a legislação, não indicou a sua real disponibilidade nos fertilizantes comerciais, mostrando a necessidade de uma definição de extratores para esse fim.

  18. Nonislet Cell Tumor Hypoglycemia

    OpenAIRE

    Johnson Thomas; Salini C. Kumar

    2013-01-01

    Nonislet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia. It is characterized by increased glucose utilization by tissues mediated by a tumor resulting in hypoglycemia. NICTH is usually seen in large mesenchymal tumors including tumors involving the GI tract. Here we will discuss a case, its pathophysiology, and recent advances in the management of NICTH. Our patient was diagnosed with poorly differentiated squamous cell carcinoma of esophagus. He continued to be hypoglycemic ...

  19. Effects of the low-intensity red laser radiation on the fluoride uptake in enamel. A clinical trial; Avaliacao dos efeitos da radiacao laser de emissao vermelha em baixa intensidade na incorporacao de fluor no esmalte. Estudo clinico

    Energy Technology Data Exchange (ETDEWEB)

    Nakasone, Regina Keiko

    2004-07-01

    Fluoride has been the most important preventive method on development of the caries. This in vivo study evaluated the effects of low-intensity red laser radiation on the fluoride uptake in enamel. Ten healthy participants were recruited for this study. The two maxillary central incisors of each volunteer to be biopsied were used and divided into 4 groups: group G{sub C} (control, which was untreated; group G{sub F} (fluoride), which received topical acidulated phosphate fluoride (APF) 1,23% treatment for 4 minutes; group G{sub LF} (laser + fluoride), which was irradiated with a low-intensity diode laser ({lambda}= 660 nm and dose= 6 J/cm{sup 2}) with APF application after irradiation and group G{sub FL} (fluoride + laser), which received APF before irradiation using the same parameters as G{sub LF}. The determination of fluoride was performed using a fluoride ion electrode after an acid-etch enamel biopsy. The results show a significant increase of the fluoride uptake in enamel for groups G{sub F}, G{sub LF} and G{sub FL} when compared to control group. Although a percentage increase of 57% was observed for G{sub LF} with respect to G{sub F}, there were no statistical differences among treated groups. These findings suggest that low-intensity laser radiation used before APF could be employed in the clinical practice to prevent dental caries. (author)

  20. Assessment of the occupational exposure of the workers involved in the {sup 123}I production at the IEN/CNEN-RJ; Avaliacao da exposicao ocupacional dos trabalhadores envolvidos na producao de {sup 123}I no IEN

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Francisco de

    2005-07-01

    {sup 123}I is a gamma emitter used for diagnosis in Nuclear Medicine. Since 1998 it is produced in the Institute of Nuclear Energy (IEN) and supplied to the Clinics and Hospitals located in the city of Rio de Janeiro. The annual production is in the approximately of 0,74 TBq (20 Ci), which represents a risk of external and internal exposure to the workers involved in this activity. A survey of external doses in the period of 1994 to 2004 was carried out based on the individual registries available in the CONEXO Data Base operated by the Institute of Radiation Protection and Dosimetry (IRD). It was verified an increase of the external exposure associated to the production curve. However, the individual doses are all bellow the annual limits established by the regulatory board. On the other hand, the variation of doses among individuals involved in the same tasks suggests the possibility of optimization of procedures. Regarding internal exposure it was calculated a decision factor above 1mSv for the practice, which justifies the need for internal monitoring. An evaluation of the process based on the results of in vivo thyroid monitoring in the period of 2000 to 2004 was carried out to identify the steps which represent higher risk of internal exposure. The available data indicate that the laboratory of quality control is the critical step in terms of internal contamination. This conclusion can be justified by the high volatility of iodine which is manipulated in the form of a liquid open source during this step. With the aim of optimizing monitoring procedures for the control of occupationally exposed workers in the production of {sup 123}I, in vivo and in vitro bioassay methods were developed to identify and quantify internal contamination by such radionuclide, using the detection systems available at the Bioassay Laboratory and at the In Vivo Measurements Laboratory. The techniques developed present sensitivity compatible with the derived registry level associated to the committed effective dose equivalent of 1mSv. It was also established a methodology for the interpretation of bioassay data using the software AIDE. The methods developed in this work can be used to implement improvements in the radiation protection program of the IEN. It is suggested to increase the frequency of in vivo measurements and to include in vitro bioassay in the monitoring program, which will permit a better evaluation of the internal doses of the workers(author)

  1. Evaluation of failure modes of computerized planning phase of interstitial implants with high dose rate brachytherapy using HFMEA; Avaliacao dos modos de falha do planejamento computadorizado em implantes intersticiais com braquiterapia de alta taxa de dose usando HFMEA

    Energy Technology Data Exchange (ETDEWEB)

    Biazotto, Bruna; Tokarski, Marcio, E-mail: bruna@ceb.unicamp.br [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Centro de Engenharia Biomedica

    2014-08-15

    This paper evaluates the failure modes of the computerized planning step in interstitial implants with high dose rate brachytherapy. The prospective tool of risk management Health Care Failure Mode and Effects Analysis (HFMEA) was used. Twelve subprocesses were identified, and 33 failure modes of which 21 justified new safety actions, and 9 of them were intolerable risks. The method proved itself useful in identifying failure modes, but laborious and subjective in their assessment. The main risks were due to human factors, which require training and commitment of management to their mitigation. (author)

  2. Thoracic x-ray in pediatrics: entrance doses evaluation in the skin of the patients; Raios X de torax em pediatria: avaliacao de doses de entrada na pele dos pacientes

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, Eliane; Borges, Jose C. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear; Mota, Helvecio C.; Briquet, Claudia [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil); Rosa, Luis Antonio [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil)

    1998-07-01

    The doses received by children in diagnostic radiology are an important concern on radiological protection due to the potential risk involved, however there is few information about the doses involved in the pediatric exams. This work evaluates the entrance skin doses in children chest examination (ESD), using thermoluminescent dosimeters. The doses presented a range from 0,01 mGy to 0,67 mGy. It was observed that for some age groups the evaluated doses were above the values recommended by European Community. (author)

  3. Radiation effects evaluation for electrons sheaf in packages resistance in a Lasioderma serricorne, Plodia interpunctella and Sitophilus zeamais; Avaliacao dos efeitos da radiacao por feixe de eletrons na resistencia de embalagens a Lasioderma serricorne, Plodia interpunctella e Sitophilus zeamais

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Juliana Nazare

    2011-07-01

    The plagues of stored products consist of a man problem, depreciating products and causing economical damages. Among these curses we have Lasioderma serricorne (F. 1792), Sitophilus zeamais (M. 1855) and Plodia interpunctella (H. 1813) known by infesting stored products as: grains, brans, flours, coffee, tobacco, dried fruits and spices. These curses perforate and penetrate the packages, ovipositing over the substratum. In this context the package plays a fundamental part, preventing the contact and curses' proliferation in the packed product. So, to protect the packed product and to prolong its shelf life, the package should have good mechanical resistance to tension and perforation, good sealing, good barrier properties and should not transfer odors nor strange flavors to the packed product. The ionizing radiation can cause structural changes in polymer packages, these changes are caused by the scission processes and reticulation of the polymers chains. These are concurrent processes and the predominance of one over the other depends on the chemical structure of the polymer, the irradiation conditions and specific factors of the material that will absorb the energy. This work had the objective to evaluate the changes in mechanical properties of package structures used to store granola, cereal bar and pasta, as well as its resistance to perforation by L. serricorne, P. interpunctella and S. zeamais, when submitted to electrons sheaf radiation. In this methodology were used five structures of commercially utilized packages to store granola, cereal bar and pasta composed by (Polypropylene bi-oriented metallic/Polypropylene bi-oriented coextruded - BOPPmet/BOPP 50 {mu}m), (Polypropylene bi-oriented/Polypropylene - BOPP/PP 50 {mu}m), Poli (ethylene terephthalate) metallic/Polypropylene bi-oriented coextruded - PETmet/BOPP 32 {mu}m), Poli (ethylene terephthalate) /Polypropylene - PET/PP1 72 {mu}m), Poli (ethylene terephthalate)/Polypropylene - PET/PP2 32 {mu}m). The structures of packaging were submitted to radiation doses between 0, 10, 20 and 60 kGy, in one electron accelerator of 1,5 M and V, 25 mA and 37,5 kW, dose tax of 11,22 kGy / s, room temperature and air presence . Eight days, Two and Six months after irradiations, mechanical resistance experiment were accomplished to tension and elongating in rupture, sealing resistance and perforation resistance, all based in respective ASTM norms. The perforation experiment by insects were realized in an acclimatized room, where irradiated samples in doses of 0, 10, 20 and 60 kGy were sealed containing 40 g of granola, 40 g of pasta and cereal bar in number of nine by experiment, and equally divided in three plastic screened boxes by studied dose. In each box 20 adults of each insect were added in for 60 days, when the packages were evaluated to verify possible perforations. The differences between the sample results were statistically evaluated by ANOVA (p<0.05). The results showed that concerning the perforation resistance by L. serricorne, P. interpunctella and S. zeamais the polymeric structures evaluated showed low resistance by insects perforation before and after the treatment. BOPPmet/BOPP (50 {mu}m), PETmet/BOPP (32 {mu}m), PET/PP1 (72 {mu}m) and PET/PP2 (32 {mu}m) structures showed significant losses in mechanical properties studied. The BOPP/PP (50 {mu}m) showed the best set of answers in mechanical properties to the radiation treatment with electrons sheaf up to 10 kGy doses. Among the mechanical properties evaluated, sealing was the most affected by ionizing radiation, has shown, in general, increasing losses with radiation dose. (author)

  4. Assessing the safety aspects for use of multilayer pipes in gas distribution of domestic installation; Avaliacao dos aspectos de seguranca para utilizacao de tubos multicamada em instalacoes de distribuicao de gas em residencias

    Energy Technology Data Exchange (ETDEWEB)

    Bratfisch, Carlos do Amaral Coutinho [Bratfisch - Engenharia em Gas, Sao Paulo, SP (Brazil); Emmeti, Sao Paulo, SP (Brazil); Collela, Ricardo [FGS Brasil Industria e Comercio Ltda., Cotia, SP (Brazil)

    2012-07-01

    The gas distribution networks average flow at the Brazilian market is low and the operating pressure is less than 2.0 kgf/cm{sup 2}. These values are lower if compared to other countries and due this, gas distribution companies, major builders and developers have started a movement to find alternatives to reduce their installation costs, and they have identified in other countries the multilayer system. Because of the great interest of the consumer market for this alternative, and since there is no standards in Brazil that could regulate it, a technical committee was established under the ABNT in order to prepare a standard draft meeting the local market particularities as well this technology requirements. Then it was initiated a quest looking for the knowledge of the 'state of the art' of this technology in various locations around the world, especially Europe, Asia and Oceania, which shows that, with few exceptions, the knowledge of this alternative is still on the beginning, and even in countries where this system is a pioneer some doubts exist with respect to their usage limit. The multilayer system materials were already used at hot and cold water networks for more than twelve years, but only after that it was made an adaptation for building installations of gas distribution networks. Due the need to search and establish safety criteria both with respect to the product as its installation shape, did the necessary motivation to perform a more detailed study of this new technology, meeting the needs of this market. The intention is to present to the consumer market a series of comparative data definitions and techniques to identify this as a modern, updated, economic, efficient and safe alternative option for gas distribution networks. (author)

  5. Evaluation of the ionizing radiation effects in microbiology, physical and chemical and sensory aspects of ice cream; Avaliacao dos efeitos da radiacao ionizante nos aspectos microbiologicos, fisico-quimicos e sensoriais de sorvetes

    Energy Technology Data Exchange (ETDEWEB)

    Rogovschi, Vladimir Dias

    2015-06-01

    The ice cream is defined as an emulsion of fats and proteins or a mixture of water and sugar, other ingredients may be added provided since they do not affect the product. It is considered a food of high nutritional value, providing lipids, carbohydrates, protein, calcium, phosphorus, and other minerals and vitamins (A, B1, B2, B6, C, D, E and K), and it is considered one of the most important products and higher interest to the dairy industry due to great demand by the consumers. The diseases related to food consumption are considered one of the most significant problems. Several outbreaks related to microbiological contamination of ice cream have been reported in recent decades in Asia, Europe and America. It is believed that the ice cream, as a frozen food, presents no risk to the population health. However, it is considered an excellent environment for the growth of microorganisms due to its composition, pH close to neutrality and long storage period. The aim of this study was to evaluate the microbiological, sensory and physicochemical aspects of ice cream. The ice cream samples were irradiated with gamma rays (60Co) with the doses of LOkGy, 2.0kGy, 3.0kGy and 4.0kGy. The samples intended for the inoculation of Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 11229) and Salmonella abaetetuba (ATCC 35640) have been irradiated with doses of 1.0, 2.0 and 3.0kGy. It can be concluded that the dose of 3.0kGy was adequate to reduce most of the studied microorganisms to undetected levels. The use of gamma radiation affected the texture and the parameters of the colorimetric analyses of the ice cream. The results of the sensorial analyses showed that the better accepted dose was 3.0kGy. (author)

  6. Study of the heterogeneity effects of lung in the evaluation of absorbed dose in radiotherapy; Estudo dos efeitos da heterogeneidade de pulmao na avaliacao da dose absorvida em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Luciana Tourinho

    2006-02-15

    The main objective of radiotherapy is to deliver the highest possible dose to the tumour, in order to destroy it, reducing as much as possible the doses to healthy tissues adjacent to the target volume. Therefore, it is necessary to do a planning of the treatment. The more complex is the treatment, the more difficult the planning will be, demanding computation sophisticated methods in its execution, in order to consider the heterogeneities present in the human body. Additionally, with the appearing of new radiotherapeutic techniques, that used irradiation fields of small area, for instance, the intensity modulated radiotherapy, the difficulties for the execution of a reliable treatment planning, became still larger. In this work it was studied the influence of the lung heterogeneity in the planning of the curves of percentage depth dose, PDP, obtained with the Eclipse{sup R} planning system for different sizes of irradiation fields, using the correction algorithms for heterogeneities available in the planning system: modified Batho, general Batho and equivalent tissue-air ratio. A thorax phantom, manufactured in acrylic, containing a region made of cork to simulate the lung tissue, was used. The PDP curves generated by the planning system were compared to those obtained by Monte Carlo simulation and with the use of thermoluminescent, TL, dosimetry. It was verified that the algorithms used by the Eclipse{sup R} system for the correction of heterogeneity effects are not able to generate correct results for PDP curves in the case of small fields, occurring differences of up to 100%, when the 1x1 cm{sup 2} treatment field is considered. These differences can cause a considerable subdosage in the lung tissue, reducing the possibility of the patient cure. (author)

  7. Radiation exposure evaluation of the professional working interventionist procedures in a hemodynamics service; Avaliacao da exposicao a radiacao dos profissionais que executam procedimentos intervencionistas em um servico de hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Da Silva, Leonardo Peres

    2004-07-01

    An evaluation of the dose distribution received by all the workers involved on coronary angioplasty, arteriography, coronary angiography and mitral valvuloplasty procedures has been made in this work. For the measurements, LiF:Mg, Ti TLD(TLD 100) was used, located in seven different points on the worker's body: hands, knees, neck, forehead and thorax, inside and outside lead apron.) The measurements have been done for each hemo dynamical procedure, and the TLD calibrated in personal dose equivalent (H{sub p}(d)) operational quantity for 0,07 mm, 3 mm and 10 mm depth. Nurses and auxiliary doctors did not receive expressive dose values, indicating that the adopted radioprotection procedures seem to be appropriate and sufficient for them. However, the same is not true for the doctors direct in charge of the procedure. The results show the importance of the use of thyroid protections in these cases. This work discusses the main factors that cause occupational dose increase. From all interventionist hemo dynamical procedures analyzed, the dose values received by the doctors on coronary angioplasty procedures and coronary angiography were higher than the ones found on arteriography and mitral valvuloplasty. The higher dose values has been found for coronary angiography procedures in X-ray tools, that work with fluoroscopy on continuous mode and have been executed with brachial way, even in the eyes, hands, knees and thyroid, with or without shield. Multiplying these high dose values, measured in one procedure by the mean number of annual procedures made at the studied hospital by each doctor, the individual dose annual limits can be surpassed. Based on these estimations, some optimizations suggestions have been made and one discussion about the need of additional monitoring points is presented. Different algorithms have been used in order to estimate the effective dose, including a new proposal. The obtained results using the actual Radiodiagnostic Brazilian regulation underestimate the dose, in the major part of the measured cases. The proposed algorithm seem sto offer a better estimation for the occupational effective dose for Interventional Radiology. (author)

  8. Methodology for evaluation of the stability of electric systems of offshore oil platforms in interconnected operations; Metodologia para a avaliacao dos sistemas eletricos das plataformas de petroleo offshore em operacao interligada

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Dalmo Junior; Mendes, Pedro Paulo de Carvalho [Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2004-07-01

    The electric system of the platforms usually operates in an isolated way, requesting therefore a redundancy in the generating units so that a can have a reliable and uninterrupted system of their loads. A way to improve the quality in operation in terms of safety, reliability and economy can be the connection of the platforms of petroleum that are close, since it is viable. The objective of this work is to show the methodology for the stability study of the electric system in interlinked operation in way to detail the data of the equipment that are necessary, as: One line Diagram; Transmission lines; Transformers; Power system compensator; Generating; Speed regulators; Voltage regulators; Turbines and other. Another focus of the work is to show some control models and regulation of the electric system to maintain it stable and to show models for the interconnection of two or more platforms. (author)

  9. Irradiation effects of GaAlAs ({lambda}=830 nm) laser on oral traumatic ulceration; Avaliacao dos efeitos da irradiacao de ulceras traumaticas na cavidade bucal com o laser de GaAlAs ({lambda}=830 nm)

    Energy Technology Data Exchange (ETDEWEB)

    Senna, Andre Machado de

    2003-07-01

    Low intensity GaAlAs ({lambda}=830 nm) laser irradiation effects on oral traumatic ulceration were evaluated. For this purpose, twenty patients presenting orthodontic appliance - induced oral traumatic ulceration were randomly distributed in two groups. Patients in group 1 were submitted to the irradiation procedure and group 2 was the control one. The irradiation parameters employed were the following: wavelength 830 nm, one single application of 4 J/cm{sup 2}, punctual in the contact mode and 30 mW power. The control group received the conventional treatment, consisting on topical application of Triancinolon based ointment four times a day. For both groups the agent responsible for the trauma was removed or covered with utility wax whenever removal was impossible. The results were evaluated concerning the wounds size reduction and pain relief. The time of laser irradiation was considered the starting time (time zero) and analysis were done 24 hours, 48 hours and seven days after that. The statistical analysis showed an acceleration in the healing process as well accentuated pain reduction for the irradiated group compared to the control one. These evidences allows us to indicate this protocol of one single application of 4 J/cm{sup 2} as therapy when patients with oral traumatic ulceration can not attend several sessions for a multiple application procedure. (author)

  10. Study of the contribution of the different components of atmospheric cosmic radiation in dose received by the aircraft crew; Avaliacao da contribuicao dos diferentes componentes da radiacao cosmica atmosferica na dose em tripulacoes de aeronaves

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Marlon A.; Prado, Adriane C.M., E-mail: adriane.acm@hotmail.com, E-mail: marlon@ieav.cta.br [Instituto Tecnologico de Aeronautica (ITA/DCTA), Sao Jose dos Campos, SP (Brazil); Federico, Claudio A.; Goncalez, Odair L., E-mail: claudiofederico@ieav.cta.br, E-mail: odairl@ieav.cta.br [Instituto de Estudos Avancados (IEAv/DCTA), Sao Jose dos Campos, SP (Brazil)

    2014-07-01

    The crews and aircraft passengers are exposed to atmospheric cosmic radiation. The flow of this radiation is modulated by the solar cycle and space weather, varying with the geomagnetic latitude and altitude. This paper presents a study of the contributions of radiation in total ambient dose equivalent of the crews depending on flight altitude up to 20 km, during maximum and minimum solar and in equatorial and polar regions. The results of calculations of the particle flows generated by the EXPACS and QARM codes are used. The particles evaluated that contributing significantly in the ambient dose equivalent are neutrons, protons, electrons, positrons, alphas, photons, muons and charged pions. This review allows us to characterize the origin of the dose received by crews and also support a project of a dosimetric system suitable for this ionizing radiation field in aircraft and on the ground.

  11. In vitro evaluation of ionizing radiation effects in bone tissue by FTIR spectroscopy and dynamic mechanical analysis; Avaliacao in vitro dos efeitos da radiacao ionizante em tecido osseo bovino por espectroscoia ATR-FTIR e analise dinamica-mecanica

    Energy Technology Data Exchange (ETDEWEB)

    Veloso, Marcelo Noronha

    2013-07-01

    Ionizing radiation from gamma radiation sources or X-ray generators is frequently used in Medical Science, such as radiodiagnostic exams, radiotherapy, and sterilization of haloenxerts. Ionizing radiation is capable of breaking polypeptidic chains and causing the release of free radicals by radiolysis.of water. It interacts also with organic material at the molecular level, and it may change its mechanical properties. In the specific case of bone tissue, studies report that ionizing radiation induces changes in collagen molecules and reduces the density of intermolecular crosslinks. The aim of this study was to verify the changes promoted by different doses of ionizing radiation in bone tissue using Fourier Transform Infrared Spectroscopy (FTIR) and dynamic mechanical analysis (DMA). Samples of bovine bone were irradiated using Cobalt-60 with five different doses: 0.01 kGy, 0.1 kGy, 1 kGy, 15 kGy and 75 kGy. To study the effects of ionizing irradiation on the chemical structure of the bone, the sub-bands of amide I, the crystallinity index and relation of organic and inorganic materials, were studied. The mechanical changes were evaluated using the elastic modulus and the damping value. To verify whether the chemical changes and the mechanical characteristics of the bone were correlated, the relation between the analysis made with spectroscopic data and the mechanical analysis data was studied. It was possible to evaluate the effects of different doses of ionizing radiation in bone tissue. With ATR-FTIR spectroscopy, it was possible to observe changes in the organic components and in the hydroxyapatite crystals organization. Changes were also observed in the elastic modulus and in the damping value. High correlation with statistical significance was observed among (amide III + collagen)/{sub v1,v3}, PO{sub 4}{sup 3-} and the delta tangent, and among 1/FHWM and the elastic modulus. (author)

  12. Evaluation of gains of energy efficiency in illumination with the use of proposed rulemaking labeling for buildings; Avaliacao dos ganhos em eficiencia energetica em iluminacao com o uso da proposta de regulamentacao de etiquetagem para edificios

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Guilherme Augusto Marques; Saidel, Marco Antonio [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica], Emails: guilherme.araujo2@poli.usp.br, saidel@usp.br

    2009-07-01

    This article aims to examine the gains in energy efficiency through the classification levels, assigned to the installation of lighting systems with the use of the proposed regulations for voluntary labeling of the level of energy efficiency in commercial buildings, and public services. Were produced three different simulations: the first, considering a survey of data in an existing building which is hosting an administrative part of the public power, composed of 275 dependences. The second and third simulations deal with the application in a lighting project in the same enterprise, in two different luminaries (composed of optical systems with and without fins, respectively). From these activities that guide the direct application of the methodology for preparation of projects have been established comparisons between the results and made comments on the rates of illuminance, the levels of efficiency and the use of luminaries. (author)

  13. Comparison of ultrasonography, computed tomography and magnetic resonance imaging with intraoperative measurements in the evaluation of abdominal aortic aneurysms; Comparacao entre ultrassonografia, tomografia computadorizada e ressonancia nuclear magnetica com medidas intra-operatorias na avaliacao dos aneurismas de aorta abdominal

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, Francisco das Chagas de; Zerati, Antonio Eduardo; Blasbalg, Roberto; Wolosker, Nelson; Puech-Leao, Pedro [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Hospital das Clinicas]. E-mail: nwolosker@yahoo.com.br

    2005-01-15

    Purpose: To study the imaging exams more commonly used for abdominal aortic aneurysms evaluation - ultrasonography, conventional computerized tomography, helical computerized tomography and nuclear magnetic angio resonance - comparing the preoperative measurements reached by those radiological methods with the measurements made during the surgical procedures. Methods: Patients who had indication of elective transperitoneal surgical treatment for their abdominal aortic aneurysms were included in the study. The initial diagnosis of the aortic dilatation was made by ultrasonography and, after the surgical treatment was indicated, the patient was submitted to another imaging method.Sixty patients were divided into 3 groups according to the complementary imaging method (conventional computerised tomography, helical computerized tomography, nuclear magnetic angio resonance). The ultrasonography of the first 20 patients were joined in a fourth group. There were considered in the study the measurements of the transversal diameter of the proximal neck, maximum transversal diameter of the aneurysm, straight-line length and transversal diameter of the common iliac arteries given by the imaging methods. The same measurements were made by using a caliper during the surgical procedure, and then compared to the values obtained from the radiological exams.Results: The maximum transverse diameter had a range measurement variation of 4.5 to 13.6 cm in the intraoperative, with no statistically significant differences when compared with all the imaging tests. The ultrasonography, however, overestimated the measurements of the proximal neck and the common iliac arteries, in comparison with intraoperative measures. The length of the aorta aneurysm obtained by the conventional computerized tomography was significantly lower if compared to the measures done with the calliper during the operation. The helical computerized tomography and the nuclear magnetic angio resonance provided measurements with no significant differences in the statistic view when compared to the intraoperative measures. Conclusions: Ultrasonography is a reliable method for the diagnosis and follow-up of the aorta abdominal aneurysms, but insufficient for endovascular surgery planning. The conventional computed tomography can provoke distortion in the length measurements of the aorta dilatation. Helical computed tomography and nuclear magnetic angio resonance provided precise measurements of all the studied parameters, being of great utility for surgical planning. (author)

  14. Evaluation of the effects of gamma radiation in minimally processed vegetables of Brassica oleracea species; Avaliacao dos efeitos da radiacao gama em vegetais da especie Brassica oleracea minimamente processados

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Thaise Cristine Fernandes

    2009-07-01

    The consumption of collard greens (Brassica oleracea cv. acephala) and broccoli (Brassica oleracea L. var. italica) has been inversely associated with morbidity and mortality caused by degenerative diseases. These species are highly consumed in Brazil, which enables its use as minimally processed (MP). The growing worldwide concern with the storage, nutritional quality and microbiological safety of food has led to many studies aimed at microbiological analysis, vitamin and shelf life. To improve the quality of these products, radiation processing can be effective in maintaining the quality of the product, rather compromising their nutritional values and sensory. The aim of this study was to evaluate the effectiveness of gamma radiation from {sup 60}Co at doses of 0, 1.0 and 1.5 kGy on the reduction of microbiota in these plants, and analyze their nutritional and sensory characteristics. The methodology used in this study was microbiological analysis, colorimetric analysis, analysis of phenolic compounds, antioxidant analysis and sensory analysis. The microbiological analysis showed a decrease in the development of populations of aerobic microorganisms, psychotropic and yeast and mold with increasing doses of radiation. The sensory analysis showed no significant difference between different times of cooking analyzed. The analysis of phenolic compounds, significant differences between the samples, suggesting that with increasing dose of irradiation was an increase in the amount of phenolic compounds found in broccoli and collard greens MP. It can be observed that the sample of control collard greens showed high antioxidant activity and for the samples treated by irradiation was a decrease of percentage. In contrast the samples of broccoli show an increase in the rate of scavenging DPPH with increase of the dose of radiation. The colorimetric analysis revealed that for samples of MP collard greens and broccoli foil of no significant differences, but for samples of stems of broccoli significant difference on the yellowing during storage. It is concluded that the processing of collard greens and broccoli butter by gamma radiation may be a viable alternative to the industry, since there was a reduction of the population of microorganisms, without changes in the sensory qualities and with minimum changes in the characteristics that confer antioxidant power. (author)

  15. Evaluation of the environmental conditioning factors in the perspective of expansion of ethanol production in Brazil; Avaliacao dos condicionantes ambientais na perspectiva de expansao da producao de etanol no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Conceicao Elaine Cardoso

    2010-03-15

    Various countries have studied the possibility of adding ethanol to gasoline or using pure fuel ethanol as an alternative to petroleum derivatives. Brazil occupies a leading position in this scenario because with its National Alcohol Program (Programa Nacional do Alcool - PROALCOOL), created in 1975, it became the pioneer in setting up a biofuels program. Since then it has accumulated experience and gained mastery of the technology to produce ethanol from sugarcane. Hence there is a strong expectation that the country can become the world's main ethanol exporter. This thesis examines the main environmental impacts associated with the ethanol productive chain, which are relevant conditioning factors for the expansion of this industry in Brazil. The study describes the evolution of PROALCOOL and the overview of current structure of the brazilian sugar-alcohol sector, identifies technologies and environmental management policies, and presents the perspective of expansion of ethanol production. Thus, the study undertakes an extensive review of the literature and examines to what extent the creation and implementation of public and private environmental management policies (legal restrictions and market instruments, respectively) interfere with the expansion of these productive activities. (author)

  16. Evaluation of gamma irradiation effects on carotenoids, ascorbic acid and sugar contents of buriti fruit (Mauritia flexuosa L.); Avaliacao dos efeitos da radiacao gama nos teores de carotenoides, acido ascorbico e acucares do fruto Buriti do Brejo (Mauritia flexuosa L.)

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Antonio Luis dos Santos [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Quimica, Quimica Organica e de Produtos Naturais], e-mail: santoslima@ime.eb.br; Lima, Keila dos Santos Cople; Silva, Jaqueline Michele [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Nuclear. Irradiacao de Alimentos], e-mail: keila@ime.eb.br, e-mail: jaquelinefisica@bol.com.br; Coelho, Maysa Joppert [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Nuclear. Engenharia Ambiental], e-mail: maysa@ime.eb.br; Godoy, Ronoel Luiz de Oliveira [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil). Lab. de Cromatografia Liquida, Quimica Organica e de Produtos Naturais], e-mail: ronoel@ctaa.embrapa.br; Pacheco, Sidney [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil). Lab. de Cromatografia Liquida, Ciencia e Tecnologia de Alimentos], e-mail: sidney@ctaa.embrapa.br

    2009-07-01

    Buriti (Mauritia flexuosa L.), a typical fruit from the Northeast and Center-West Amazon of Brazil, is used in many regional dishes. It is considered an excellent source of carotenoids that are A vitamin precursors, showing a majority of beta-carotene. It also presents ascorbic acid and sugar contents. Many studies have indicated that the lack of A vitamin is the main cause of night blindness and xerophthalmia. Also, ascorbic acid deficiency may cause scorbutic disease. The use of food irradiation is growing and represents an economic benefit to agriculture through the reduction of post-harvesting losses while maintaining food nutritional quality. In this study, buriti in natura was treated with gamma irradiation with doses of 0.5 kGy and 1.0 kGy. The objective was to evaluate the irradiation effects on total carotenoids, ascorbic acid and sugars concentrations of buriti. The fruit was evaluated through the total carotenoids analysis, by spectrophotometry, and the carotenoids (alpha and beta-carotene and lutein), ascorbic acid and sugars were determined by high performance liquid chromatography (HPLC). The results showed that buriti is an excellent source of total carotenoids (44600 {mu}g/100 g). The irradiation of buriti with the dose of 0.5 kGy did not significantly change carotenoids and sugars contents. However, there was a reduction of ascorbic acid concentration with an increase of the dose, which may have been caused by irradiation or by intrinsic and extrinsic factors that alter ascorbic acid stability in food, converting ascorbic to dehydroascorbic acid, while keeping the C vitamin active form. (author)

  17. Disinfection of effluent of wastewater treated using solar energy (SODIS): evaluation of a solar concentrator device; Desinfeccao de efluentes com tratamento terciario utilizando energia solar (SODIS): avaliacao do uso do dispositivo para concentracao dos raios solares

    Energy Technology Data Exchange (ETDEWEB)

    Paterniani, Jose Euclides Stipp; Silva, Marcelo Jacomini Moreira da [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Faculdade de Engenharia Mecanica. Saneamento e Ambiente]. E-mail: pater@agr.unicamp.br

    2005-01-15

    Besides being an available natural resource, the solar energy is very applicable in places with few recourses and low money resources, because there aren't either the need of chemical products neither a huge cost (commercial materials can be reused). To make this job we re-used PET bottles half painted black with the variables: 1, 2, 4 and 6 hours of heat exposition and we also used a concentrator of rays of sunshine. The affluent control parameters were turbidity, apparent color, temperature, total coliforms and E. coli. These last three were evaluated before and after the disinfection process (effluent parameters). To assess the bacteria reactivation we kept the water in bottles for 24 hours, pretending a very common situation in Brazilian rural houses. We conclude that the use of the concentrator of rays of sunshine can reduce the heat exposition from 6 to 4 hours, without harm the SODIS efficiency. Using the concentrator of rays of sunshine for 6 hours we can obtain, besides SODIS, the process of solar pasteurization (SOPAS), which stops the re-growth of bacteria with a 70 deg C water temperature. We also observed that when the sky is cloudy the incidence of solar radiation and, therefore, the SODIS efficiency decrease, even if the water temperature is higher during the disinfection. Although, this factor doesn't mean a significant influence statistically. (author)

  18. Computed tomography prospective study of pleural-pulmonary changes after abdominal surgery : assessment of associated risk factors; Estudo prospectivo por tomografia computadorizada das alteracoes pleuro-pulmonares apos cirurgia abdominal: avaliacao dos fatores de risco associados

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Luis Antonio [Pontificia Univ. Catolica de Sao Paulo, SP (Brazil). Centro de Ciencias Medicas e Biologicas]. E-mail: luizrossimd@uol.com.br; Bromberg, Sansom Henrique [Instituto de Assistencia Medica ao Servidor Publico Estadual de Sao Paulo (IAMSPE), Sao Paulo, SP (Brazil). Curso de Pos-graduacao em Gastroenterologia Cirurgica

    2005-07-01

    Postoperative pleural-pulmonary changes (PPC) are very common following elective abdominal surgery, resolving without clinical manifestations in most patients. The incidence and risk factors associated are unknown. Objective: to determine the incidence of PPC and possible association with risk factors using computerized tomography (CT). Material and method: thirty seven patients submitted to elective abdominal surgery were prospectively analyzed using CT performed in the preoperative period and 48 hours after surgery. The PPC was scored from 0 to III. The risk factors evaluated were: age, sex, obesity, smoking history, alcoholism, comorbid conditions, cancer, ASA classification, duration of surgery, surgical incision type and number of days of hospitalization. Results: Pleura effusion was detected by CT in 70.3% (26/37) of the patients and pulmonary atelectasis in 75.5% (28/37). Grade I and II PPC was found in 59.5% (22/37) of the patients and grade III in 21.6% (8/37). Two (5.4%) of these patients developed serious pulmonary complications whereas one patient died. Surgery due to cancer, class ASA >2, longitudinal incision and > 15 cm showed statistical significance and were associated with pleural effusion. The hospitalization was over 2.4 longer for patients with PPC. Conclusion: PPC is frequently seen in patients submitted to abdominal surgery. The use of the CT for the detection of pulmonary atelectasis and pleural effusion proved to be effective. Most cases of PPC are self-limited, resolving without symptoms. (author)

  19. Use of the HRICP-MS technique for the evaluation of boron isotopes in Eucalitpus plants; Uso da tecnica HRICP-MS na avaliacao dos isotopos de boro em eucalipto

    Energy Technology Data Exchange (ETDEWEB)

    Mattiello, Edson Marcio; Ruiz, Hugo Alberto; Silva, Ivo Ribeiro da, E-mail: mattiello@ufv.b [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Solos; Sarkis, Jorge Eduardo de Souza [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The {sup 10}B isotope tracer technique is essential to study the B mobility in plants. Factors that can influence the quality of measured B isotope ratios were optimized experimentally using High Resolution Inductively Coupled Plasma Mass Spectrometry (HRICP-MS). An isotopically certified standard (NIST SRM-951) was used. The best combination was obtained using a resolution of 400, a RF power of 1250 W, followed by 15 measurements over a 10-s integration period each (15*10). Utilizing this approach it was possible to obtain a precision of 0.3 % in standard material and 2z % in the experimental samples. The results show the importance of establishing optimized work conditions before carrying out the analytical series. (author)

  20. Dyes removal of textile wastewater onto surfactant modified zeolite from coal ash and evaluation of the toxic effects; Remocao de corantes de efluente textil por zeolita de cinzas de carvao modificada por surfactante e avaliacao dos efeitos toxicos

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Patricia Cunico

    2015-07-01

    Zeolites synthesized from fly and bottom ashes and modified with hexadecyltrimethylammonium (HDTMA) were used as adsorbent to remove dyes - Solophenyl Navy (SN) and Solophenyl Turquoise (ST) and their hydrolysed forms Solophenyl Navy Hydrolysed (SNH) and Solophenyl Turquoise Hydrolysed (STH), from simulated textile wastewater. The HDTMA-modified fly zeolite (ZMF) and HDTMA-modified bottom zeolite (ZMB) were characterized by different techniques, as X-ray fluorescence spectrometry, X-ray diffraction and scanning electron microscopy, etc. The ZMF and ZMB presented negative charge probably due to the formation of a partial bilayer of HDTMA on exchangeable active sites on the external surface of unmodified zeolite. Initial dye concentration, contact time and equilibrium adsorption were evaluated. The adsorption kinetic for SN, ST, SNH and STH onto the zeolites followed the pseudo second-order model. The equilibrium time was 20 min for SN and ST and 30 min for SNH and STH, respectively. Langmuir, Freundlich and Temkin models were applied to describe the adsorption isotherms. Adsorption of the dyes were best described by the Langmuir model, with exception to SN/ZPM, SNH/ZPM and SNH/ZLM systems that followed Freundlich model. The maximum adsorption capacities were 3,64; 3,57; 2,91 e 4,93 for SN, ST, SNH e STH by ZLM, respectively and 0,235; 0,492; 1,26 e 1,86 by ZPM, in this order. The best performance for hydrolyzed dyes has been attributed to reduction of the size of dyes molecules during the hydrolysis process. Acute toxicity of the dyes to a different organism were evaluated by different test-organisms. Waterflea, Ceriodaphnia dubia showed EC50 value of 1,25; 54,5; 0,78 and 2,56 mgL{sup -1} for SN, ST, SNH and STH, respectively. The plant Lemna minor showed EC50 values of 18,9; 69,4; 10,9 and 70,9 mgL{sup -1} for SN, ST, SNH and STH, respectively. Midges larvae of Chironomus tepperi showed EC50 values of 119 and 440 mgL{sup -1} for SN and ST, respectively. Regarding the adsorption process, acute effects were substantially reduced after adsorption treatment of aqueous solution with SN and ST by ZMF, as well as their hydrolysed forms, showing no toxicity after removal of 100% of colour. After treatment with ZPM there was an increase of the toxicity, with exception of SHN and STH dyes that do not show toxicity after the treatment. Toxicity Identification Evaluation tests (TIE) were realized in order to identify what substances were causing the observed toxicity for the SN, ST and the leached of ZMF and ZMB. The acute effects were significantly reduced after manipulation with Solid-Phase Extraction (SPE) and Ethylenediaminetetraacetic acid (EDTA) for the leached of ZMB and ZMF. The dyes showed reduced in the toxicity after manipulation with EDTA indicating that the toxicants are mostly cationic metals. (author)

  1. Evaluation of area monitor response for neutrons in radiation field generated by a 15 MV clinic accelerator; Avaliacao da resposta dos monitores de area para neutrons em campo de radiacao gerado por um acelerador clinico de 15 MV

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, Ana Paula

    2011-07-01

    The clinical importance and usage of linear accelerators in cancer treatment increased significantly in the last years. Coupled with this growth came the concern about the use of accelerators with energies over to 10 MeV which produce therapeutic beam contaminated with neutrons generated when high-energy photons interact with high-atomic-number materials such as tungsten and lead present in the accelerator itself. At these facilities, measurements of the ambient dose equivalent for neutrons present difficulties owing to the existence of a mixed radiation field and possible electromagnetic interference near the accelerator. The Neutron Laboratory of the IRD - Brazilian Institute for Radioprotection and Dosimetry, aiming to evaluate the survey meters performance at these facilities, initiated studies of instrumentation response in the presence of different neutron spectra. Neutrons sources with average energies ranging from 0.55 to 4.2 MeV, four different survey meters and one ionization chamber to obtain the ratio between the dose due to neutrons and gamma radiation were used in this work. The evaluation of these measurements, performed in a 15 MV linear accelerator room is presented. This work presents results that demonstrate the complexity and care needed to make neutrons measurements in radiotherapy treatment rooms containing high energy clinical accelerators. (author)

  2. Building and cities. Study of energetical demand in Lisbon; Os edificios e a Cidade estudio de avaliacao das necessidades energeticas dos edificios no espaco urbano, o caso da cidades de lisboa

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, H. P.; Panao, M. O.; Camelo, S. L.; Graca, J. M.; Ramalho, A. F.; Aguilar, R.

    2004-07-01

    The evaluation of the building thermal performance in an urban environment was undertaken in Lisbon city (Portugal) within the frame of ACLURE Project (Built Environment, Urban Climate and Rational Use of Energy) (Goncalves et al, 2004). In order to reveal the main parameters that affect the building thermal behavior, an experimental survey of the dwellings and the urban climate was performed and modeling facilities were also used. While the experimental results allow to infer how the dwellings interact with the urban climate, the modeling analysis estimate the average annual energy demands for different geographical and morphological conditions, namely by the canyon height- to-with ratio (H/W). (Author)

  3. An evaluation of the participation of the social movements on the decision making process and planning of the electric sector; Uma avaliacao da participacao dos movimentos sociais no planejamento e no processo decisorio do setor eletrico

    Energy Technology Data Exchange (ETDEWEB)

    Moral Hernandez, Francisco del; Bermann, Celio [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-graduacao em Energia]. E-mail: delmoral@hotmail.com; cbermann@iee.usp.br

    2006-07-01

    This work presents some reflexions on the possibility of a public sphere in the decision making process in the energetic sector. By using the conceptual mark of Juergen HABERMAS, some reflexions on the political participation specificities at Latin America, mainly those ones suggested by AVRITZER (2002) and the theoretical reflexions of HONNETH (2003) recognition fight and construction in the social movements, the work tries the verification of how far the requirements of social organizations identified in this work are from a desirable situation, or else a more effective participation of the social movements on the decisions and planning spaces and the deliberative character of the public discussion space in the area of energy.

  4. Gamma radiation (Co{sup 60}) effects on active substances and microbe burden of medicinal plants; Avaliacao dos efeitos da radiacao gama (Co{sup 60}) sobre principios ativos e carga microbiana de plantas medicinais

    Energy Technology Data Exchange (ETDEWEB)

    Dall' Agnol, L. [Herbarium Laboratorio Botanico Ltda, Colombo, PR (Brazil). Dept. de Garantia da Qualidade

    2001-04-01

    In order to evaluate the effects of radioactivity on active vegetal substances, samples of Fennel (Foeniculum vulgare Miller., fructus), Guarana (Paulinia cupana, Kunth, semen), Gingko (gingko biloba, L., folium), and Kawa-Kawa (Piper methysticum G. Forst, rhizoma), were treated with scaling doses (0 to 25 KGy) of gamma radiation (Co{sup 60}). The 'blind test' methodology was used. The active substances from each sample were analysed by qualitative and quantitative methods after radiation. There were no significant differences seen between the control sample (0 KGy) and the irradiated samples. Microbe contamination was significantly reduced, about 10000 CFU/g, with the initial 5 KGy dose. It was concluded that gamma radiation can be used as an alternative procedure to reduce microbiologic contamination in medicinal plants. Before this procedure can be extended to other medicinal plants, more specific analytical methods are recommended to verify possible structural alterations in active vegetal molecules. (author)

  5. Hemocyte characterization of Nasutitermes coxipoensis (Holmgren) (Isoptera: Termitidae) workers and hemocyte evaluation after parasitism by Metarhizium anisopliae; Caracterizacao dos hemocitos de operarios de Nasutitermes coxipoensis (Holmgren) (Isoptera: Termitidae) e avaliacao hemocitaria apos parasitismo por Metarhizium anisopliae

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Franklin M.; Wanderley-Teixeira, Valeria; Albuquerque, Auristela C. [Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE (Brazil). Programa de Pos-Graduacao em Entomologia Agricola], e-mail: ukento@yahoo.com.br; Teixeira, Alvaro A.C. [Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE (Brazil). Dept. de Morfologia e Fisiologia Animal], e-mail: valeria@dmfa.ufrpe.br, e-mail: auritermes@yahoo.com.br; Alves, Luiz C. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Lab. de Imunopatologia Keizo Asami (LIKA); Lima, Elza A.L.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Micologia. Lab. de Controle Biologico

    2009-03-15

    We aimed to characterize the morphology and ultrastructure of hemocytes of Nasutitermes coxipoensis (Holmgren) workers and to quantify the cell types 24h, 48h and 72h after inoculation with Metarhizium anisopliae. Six hemocytes types were identified, plasmatocyte, granulocyte, spherulocyte, prohemocyte, adipohemocyte and eonocytoid Hemocytes did not present any morphological alteration at the several observation periods, but they did have a change in their abundance, as observed for spherulocytes, adipohemocytes and eonocytoids at all intervals, and for plasmatocytes and granulocytes at 48h after host inoculation. We argue on the possible reasons and implications of the observed changes. (author)

  6. Evaluation of solubility in simulated lung fluid of metals present in the sludge from a metallurgical industry to produce metallic zinc; Avaliacao da solubilidade em liquido pulmonar simulado dos metais presentes no rejeito gerado por uma industria metalurgica de zinco

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Rosilda Maria Gomes de

    2012-07-01

    The objective of this study was to determine the solubility parameters (rapid and slow dissolution rates, rapid and slow dissolution fractions) metal particles present in a pile of sludge accumulated under exposure to weathering from the Cia Mercantil Inga, located at the Ilha da Madeira, Sepetiba Bay, Rio de Janeiro. Plant samples collected in the neighboring of the pile and bioindicators placed in the region and collected after some months indicated that the inhabitants of Ilha da Madeira have been exposed to trace elements such zinc, cadmium, mercury and lead, produced during the processing of zinc minerals (hemimorphite - Zn{sub 4}(OH){sub 2}Si{sub 2}O{sub 7}.H{sub 2}O, and willemite - Zn{sub 2}SiO{sub 4}). A static dissolution test in vitro was used to determine the solubility parameters using a simulated lung fluid (SLF), on a time basis ranging from 10 min to 1 year. The metal concentrations in the sludge samples and in the SLF were determined using Particle Induced X-rays Emission (PIXE). In conclusion, this study confirms the harmful effects on the neighboring population of the airborne particles containing these metals that came from the sludge. The solubility parameters obtained for Zn, Cd, Cr, Ni and Mn present in the rapid dissolution fraction in SLF were 0.945; 0.473; 0.226; 0.300 and 0.497, respectively, and the corresponding times for half life of dissolution of the rapid fraction were f{sub r} = 2.082 days; f{sub r} = 0.09 days; f{sub r} = 0.37 days; f{sub r} = 0.332 days ad f{sub r} = 0.99 days; for the slow dissolution fraction times were f{sub r} = 146.95 days; f{sub r} = 63 days; f{sub r} = 86.64 days; f{sub r} = 79.66 days and f{sub r} = 59.84 days. These values indicate that these metals present a moderate absorption level in SLF, and may be classified as M type, according to the International Commission on Radiological Protection (ICRP). The use of solubility parameters allowed a better description of the kinetic behaviour of the sludge in the human body and, therefore, a better evaluation of the worker’s risk to inhalation of airbone particles containing Zn, Cd, Cr, Ni and Mn. (author)

  7. Determination of absorbed dose in water: evaluation of dosimetric factors calibration sets used in radiotherapy; Determinacao da dose absorvida na agua: avaliacao dos fatores de calibracao de conjuntos dosimetricos de uso em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Faculdade de Medicina. Departamento de Dermatologia e Radioterapia; Fontana, Julia M.; Santos, Vitor H.P.; Nunes, Isabella P.F.; Okawabata, Francine S., E-mail: marfernandes@fmb.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Instituto de Biociencia

    2014-12-15

    This paper presents a methodology for measuring the dose rate (cGy/min) in a telecobaltotherapy beam, looking emphasize the need for calibration of dosimetric set used and the importance of conducting periodic clinical megavoltage dosimetry of these beams. Two dosimetric set with their respective calibration factors were used. The correction parameters indicated in dosimetry protocols were determined by ionization chambers used. The difference between the value of the dose rate used in the calculation of the service routine and the values obtained in this work with both dosimetric sets proved to be less than 1.5%, and therefore satisfies the maximum recommended tolerance on quality control protocols for this type of therapeutic beam. (author)

  8. Evaluation of the effects of gamma radiation on physicochemical characteristics of kiwi (Actinidia deliciosa) cv. Hayward minimally processed; Avaliacao dos efeitos da radiacao gama nas caracteristicas fisico-quimicas de kiwi (Actinidia deliciosa) cv. Hayward minimamente processado

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Ana Claudia Sampaio

    2011-07-01

    The search for a healthy life has led consumers to rethink their eating habits, consuming fruits and vegetables in place of manufactured products, therefore, the demand for minimally processed products has evolved rapidly. The kiwi fruit (Actinidia deliciosa) has high nutritional value, being rich in C vitamin especially, which has wide acceptance in consumer markets. Thus, along with papaya, passion fruit and pineapple, kiwi can be considered as an additional feature of C vitamin in the diet, or as a substitute for traditional citrus. The aim of this study was to assess the effects of gamma radiation on physical and chemical characteristics of kiwis minimally processed and stored under refrigeration, since this technology increases the shelf life of fruits and vegetables. The Kiwis was stripped, processed and cut into slices, stored in polyethylene bags of 10 cm squared and irradiated at doses of 0 (control), 1 and 2 kGy. A source of {sup 60}Co Gammacell 220, dose rate of 0.429 kGy/hour, in which each treatment had 5 replicates with 15 slices of kiwifruit per replicate. After irradiation the samples were stored in a climatic chamber at 6 degree C (near the temperature of commercial refrigerators). The following criteria were physical chemical analysis: pH, color, chlorophyll content, loss of weight, moisture, acidity and Brix. The analysis were done on 1{sup st}, 7{sup th} and 14{sup th} days after irradiation. The results indicated that gamma radiation did not induce deleterious changes in the physicochemical properties of the kiwi may be used for preservation of minimally processed kiwifruit. (author)

  9. Evaluation of multiple scan average dose (MSAD) levels in computerized tomography in Minas Gerais state, Brazil; Avaliacao dos niveis de dose media em cortes multiplos (MSAD) em tomografia computadorizada no estado de Minas Gerais

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, Thessa C., E-mail: alonso@cdtn.br [Centro de Desenvolvimento de Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Vieira, Leandro de A.; Barbosa, Nayra V.; Oliveira, Jeyselaine R. de; Cesar, Adriana C.Z. [Secretaria de Vigilancia Sanitaria de Minas Gerais, Belo Horizonte, MG (Brazil); Silva, Teogenes A. da [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear. Programa de Ciencias e Tecnicas Nucleares

    2014-07-01

    Computed Tomography (CT) grows every year and is a diagnostic method that has revolutionized radiology with advances in procedures for obtaining image. However, the indiscriminate use of this method generates relatively high doses in patients. The diagnostic reference levels (DRLs) is a practical tool to promote the evaluation of existing protocols. The optimization and the periodic review of the protocols are important to balance the risk of radiation. The present study aims to conduct a survey of levels of MSAD of Minas Gerais following the procedures recommended by current Brazilian law. (author)

  10. Evaluation of radon concentration in dwellings and well water of Parana State-Brazil; Avaliacao dos niveis de concentracao de radonio em ambientes e aguas de pocos no Estado do Parana

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Janine Nicolosi

    2011-07-01

    Considering the growing interest of International Agencies and national Governmental organs in studies and measurements of radon activity in air, soil gas and ground water (mainly from artesian wells) as well as scarceness of such measurements at Brazilian territory, present studies were initiated by the Laboratory of Applied Nuclear Physics of Federal University of Technology - Parana (UTFPR) in collaboration with the Institute of Radiation Protection and Dosimetry (IRD) and the Center of Nuclear Technology Development (CDTN) of Brazilian Commission on Nuclear Energy (CNEN). This Collaboration started in 2003. Radon monitoring program is based mainly on use of Solid State Nuclear Track Detectors for radon activity measurements in air. Continuous electronic radon detectors are used for radon measurements in soil gas and water. Current work presents the results of indoor {sup 222}Rn activity of dwellings and working places of Curitiba-PR and radon concentration in ground water samples from artesian wells from aquifers of the same area. The indoor measurements of radon activity were performed using Solid State Nuclear Track Detectors CR-39. After the exposition, CR-39 detectors were submitted to chemical development which permitted to make alpha particle tracks counting. The results of calibration of CR-39 together with efficiency of used exhalation chambers as well as alpha particle tracks chemical development procedure were performed in cooperation with CDTN and collaboration with the National Institute of Radiological Sciences (NIRS). The major part of indoor {sup 222}Rn concentration in residences was found below 100 Bq/m3. In the case of working places, all measurements present {sup 222}Rn concentration bellow 100 Bq/m3. The studies of radon activity in water were performed using the samples of water from artesian wells submitted to recursive measurements by instant radon detector AlphaGUARD PQ2000 PRO during few weeks with intervals of about 4 days between each measurement approximately. The calculations of initial radon activity in water were done considering the {sup 222}Rn decay correction as well as equilibrium level of {sup 222}Rn and {sup 226}Ra observed after 30 days of measurements. Obtained results show that about 70% measured activity levels of {sup 222}Rn are higher than recommended value of 11.1 Bq/L which represent the risk for the human health associated with this radionuclide.

  11. Study of the effect of ionizing radiation on composites based on PCL/PLLA and coconut fiber; Avaliacao dos efeitos da radiacao ionizante em compositos de PCL/PLLA com fibra de coco

    Energy Technology Data Exchange (ETDEWEB)

    Kodama, Yasko

    2011-07-01

    Plastic solid waste has become a serious problem recently concerning environmental impact. In this scenario, preparation of polymers and composites based on coconut husk fiber would lead to a reduction on the cost of the final product. Additionally, it will reduce the amount of agribusiness waste disposal in the environment. In Brazil, coconut production is around 1.5 billion fruits by year in a cultivated area of 2.7 million hectares, but the coconut husk fiber has not been used much for industrial applications. Moreover, biodegradable polymers have attracted the attention of the most part of population, due to the environmental issues arising from the increasing use of polymeric materials of low degradability discharged as waste residue. Besides, when considering an application in the medical field, it is necessary that the products are sterilized and, ionizing radiation is widely used to sterilize medical and surgical devices. In this work, it was studied blends and composites based on two commercial polymers: poly (e-caprolactone), PCL, and poly (lactic acid), PLLA, and coconut fiber. Those polymers are biodegradable as well as biocompatible, so it is important to know the effect of ionizing radiation in these materials. Samples were irradiated with gamma rays from {sup 60}Co source and electron beam with radiation doses ranging from 10 kGy up to 1 MGy. The non-irradiated and irradiated samples were studied using several analytical techniques and characterization assays that allowed understanding their properties in order to enable their application as precursors for medical and surgical devices. Thermal stability of non irradiated and irradiated composites up to 100 kGy radiation dose is not affected significantly by the coconut fiber incorporation to the polymeric matrix. Acetylation of fibers was not effective in order to induce any interaction between fibers and polymeric matrix, as expected. That was verified by the slight reduction of stress strength observed in the composites specimens. Besides that, this reduction did not affect negatively mechanical properties of blends compared to the composites. Ionizing radiation neither promoted detectable interaction between polymeric matrix and fibers. Cytotoxicity tests indicated that lixiviation products from homopolymers, blend and composites did not release sufficient amount of substances to induce significant cellular death. Thermal processing used to obtain composites and previous acetylation by chemical treatment contributed to the bioburden reduce. Furthermore, reducing initial bioburden it was possible to diminish radiation doses needed to perform sterilization. Enzymatic and soil degradation were not negatively affected by radiation processing. Even though fiber incorporation to the polymer blend slightly reduced degradation process, composites continued degrading through time. Artifacts produced by means of the materials studied here can be radiation processed with doses up to 100 kGy without prejudice of their biodegradability. (author)

  12. Soft tissue mixed tumor

    OpenAIRE

    Eiichi Hiraishi; Hiroshi Sakihara; Michiro Susa; Takayuki Honma; Hiroshi Shimosawa

    2009-01-01

    Mixed tumors are relatively common in the skin and salivary glands, but extremely rare in soft tissues, often resulting in diagnostic problems. The occurrence of these tumors in the hand is especially limited. In this article we report the clinical, radiological, and histological features of a mixed tumor of the hypothenar region of the right hand.

  13. Brain and Spinal Tumors

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Brain and Spinal Tumors Information Page Synonym(s): Spinal Cord ... en Español Additional resources from MedlinePlus What are Brain and Spinal Tumors? Tumors of the brain and ...

  14. Tumor penetrating peptides

    Directory of Open Access Journals (Sweden)

    Tambet eTeesalu

    2013-08-01

    Full Text Available Tumor-homing peptides can be used to deliver drugs into tumors. Phage library screening in live mice has recently identified homing peptides that specifically recognize the endothelium of tumor vessels, extravasate, and penetrate deep into the extravascular tumor tissue. The prototypic peptide of this class, iRGD (CRGDKGPDC, contains the integrin-binding RGD motif. RGD mediates tumor homing through binding to αv integrins, which are selectively expressed on various cells in tumors, including tumor endothelial cells. The tumor-penetrating properties of iRGD are mediated by a second sequence motif, R/KXXR/K. This C-end Rule (or CendR motif is active only when the second basic residue is exposed at the C-terminus of the peptide. Proteolytic processing of iRGD in tumors activates the cryptic CendR motif, which then binds to neuropilin-1 activating an endocytic bulk transport pathway through tumor tissue. Phage screening has also yielded tumor-penetrating peptides that function like iRGD in activating the CendR pathway, but bind to a different primary receptor. Moreover, novel tumor-homing peptides can be constructed from tumor-homing motifs, CendR elements and protease cleavage sites. Pathologies other than tumors can be targeted with tissue-penetrating peptides, and the primary receptor can also be a vascular zip code of a normal tissue. The CendR technology provides a solution to a major problem in tumor therapy, poor penetration of drugs into tumors. The tumor-penetrating peptides are capable of taking a payload deep into tumor tissue in mice, and they also penetrate into human tumors ex vivo. Targeting with these peptides specifically increases the accumulation in tumors of a variety of drugs and contrast agents, such as doxorubicin, antibodies and nanoparticle-based compounds. Remarkably the drug to be targeted does not have to be coupled to the peptide; the bulk transport system activated by the peptide sweeps along any compound that is

  15. Tumors in invertebrates

    Directory of Open Access Journals (Sweden)

    F Tascedda

    2014-06-01

    Full Text Available Tumors are ectopic masses of tissue formed by due to an abnormal cell proliferation. In this review tumors of several invertebrate species are examined. The description of tumors in invertebrates may be a difficult task, because the pathologists are usually inexperienced with invertebrate tissues, and the experts in invertebrate biology are not familiar with the description of tumors. As a consequence, the terminology used in defining the tumor type is related to that used in mammalian pathology, which can create misunderstandings in some occasions.

  16. Benign ear cyst or tumor

    Science.gov (United States)

    Osteomas; Exostoses; Tumor - ear; Cysts - ear; Ear cysts; Ear tumors; Bony tumor of the ear canal ... bony tumors of the ear canal (exostoses and osteomas) are caused by excess growth of bone. Repeated ...

  17. Intradural jugular foramen tumors Tumores intradurais do forame jugular

    Directory of Open Access Journals (Sweden)

    João Paulo Mattos

    2004-12-01

    Full Text Available Eleven patients with jugular foramen lesions with or without extradural extension were operated at University Hospital of Campinas (UNICAMP, in Campinas, Brazil, between 1998 and 2001. Neck dissection, mastoidectomy without transposition of the facial nerve and myofascial flap reconstruction of the cranial base with an especially developed technique were carried out in 7 patients. Four patients were operated using retrosigmoid craniectomy. Total excision was accomplished in 9 cases. All patients did not show evidence of disease progression at least after 2 years follow-up. There was no mortality. New lower cranial nerve deficits occurred in 5 patients. Nine maintain or improved their preoperative status based on Karnofsky and Glasgow Outcome Scale. A complex anatomy of this region demand wide exposures for treat those tumors. For this reason, an adequate approach for curative resection of most lesions and an efficient skull base reconstruction decreasing postoperative morbidity are essential.Onze pacientes com lesões expansivas do forame jugular associadas ou não a componente extradural foram submetidos a ressecção cirúrgica no Hospital das Clínicas da Universidade Estadual de Campinas (UNICAMP entre 1998 e 2001. Foi utilizada cirurgia combinada com dissecção do pescoço, mastoidectomia sem transposição do nervo facial e técnica de reconstrução miofascial da base do crânio desenvolvida por um dos autores. Quatro pacientes foram operados via craniectomia retrosigmoidea. Ressecção total foi feita em 9 pacientes, subtotal em um e parcial em outro. Nenhum dos 11 pacientes teve progressão da doença em 2 anos de acompanhamento. Não houve mortalidade. Cinco pacientes tiveram déficits adicionais de nervos cranianos baixos. Nove pacientes mantiveram ou melhoraram suas pontuações de acordo com a escala de Karnofsky. Para adequada abordagem do paciente com tumor de forame jugular, são necessários bom conhecimento anatômico da regi

  18. Epilepsy and Brain Tumors

    Institute of Scientific and Technical Information of China (English)

    Zhi-yi Sha

    2009-01-01

    @@ Epidemiology It is estimated 61,414 new cases of primary brain tumors are expected to be diagnosed in 2009 in the U.S. The incidence statistic of 61,414 persons diagnosed per year includes both malignant (22,738) and non-malignant (38,677) brain tumors. (Data from American Brain Tumor Association). During the years 2004-2005, approximately 359,000 people in the United States were living with the diagnosis of a primary brain or central nervous system tumor. Specifically, more than 81,000 persons were living with a malignant tumor, more than 267,000 persons with a benign tumor. For every 100,000 people in the United States, approximately 131 are living following the diagnosis of a brain tumor. This represents a prevalence rate of 130.8 per 100,000 person years[1].

  19. Genital soft tissue tumors.

    Science.gov (United States)

    Schoolmeester, John K; Fritchie, Karen J

    2015-07-01

    Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.

  20. impacto na cavidade oral dos pacientes

    OpenAIRE

    Barros, Gisela Cristina Moreira

    2010-01-01

    A Síndrome de Sjögren (SS) é uma patologia de origem autoimune, que se caracteriza imunológicamente, por um infiltrado linfocitário nas glândulas salivares e lacrimais dos indivíduos afectados. A SS pode-se dividir em Síndrome de Sjögren Primário e Síndrome de Sjögren Secundário. Os principais sintomas são a secura da boca, dos olhos e o cansaço extremo. A infiltração plasmática e linfocitária nas glândulas exócrinas e, consequentemente, a produção de auto-anticorpos, leva a...

  1. Metabolismo dos lípidos

    OpenAIRE

    Ibarguren Arizeta, Izaskun

    2011-01-01

    Esta unidade didáctica, Metabolismo dos lípidos, englóbase dentro da materia Bioquímica que se imparte na titulación de Grao en Veterinaria. No plano de estudos, a materia está integrada no módulo de formación básica común, impártese no primeiro semestre do primeiro curso, e ten una carga lectiva de 6 créditos ECTS. Así pois, os destinatarios son alumnos de primeiro curso de veterinaria. A Bioquímica estuda as bases moleculares dos seres vivos, isto é, como son, como interaccionan e a ...

  2. Avaliacao da espessura medio-intimal em pacientes com doenca renal cronica nao dialitica: estudo prospectivo de 24 meses

    Directory of Open Access Journals (Sweden)

    Andrea Gaspar Marcos

    2014-03-01

    Full Text Available Introdução: O aumento da espessura média-intimal (EMI avaliada por ultrassom é um preditor de risco cardiovascular na população geral. Porém, em pacientes com doença renal crônica nos estágios iniciais, essa associação ainda não está bem estabelecida. Objetivo: Avaliar a associação EMI com a ocorrência de eventos cardiovasculares e mortalidade em pacientes nos estágios iniciais da doença renal crônica. Métodos: A análise post hoc de uma coorte de pacientes nos estágios 2-4 da DRC. Foram avaliados dados laboratoriais, ultrassom da artéria carótida e tomografia coronariana no início do estudo e a ocorrência de óbito, em seguimento por 24 meses. Resultados: Um total de 117 pacientes (57 ± 11 anos, 61% sexo masculino foram avaliados. A taxa de filtração glomerular foi 36 ± 17 mL/min, 96% dos pacientes eram hipertensos, 23% diabéticos e 27% obesos. Calcificação arterial coronariana esteve presente em 48% dos pacientes, sendo mais prevalente em pacientes nos estágios mais avançados da DRC (p = 0,02. EMI foi 0,6 mm (0,4-0,7 mm. Comparado aos pacientes com EMI < 0,6mm, aqueles com EMI ≥ 0,6 mm eram mais velhos (p = 0,001, apresentavam maior prevalência do sexo masculino (p = 0,001, menor taxa de filtração glomerular (p = 0,01 e maior proporção de pacientes com calcificação (p = 0,001. Não foi observada relação entre a espessura média-intimal e a ocorrência de evento cardiovascular e óbito. Conclusão: A espessura médio-intimal em pacientes DRC se associou à calcificação coronariana, mas não à ocorrência de eventos cardiovasculares e óbito, em um seguimento de 24 meses.

  3. Differential diagnosis of tumors of the mandible and maxilla: radiological aspects; Diagnostico diferencial dos tumores da manbibula e maxila

    Energy Technology Data Exchange (ETDEWEB)

    Isberner, Rony Klaus; Nagazava, Marcio M.; Chiang, Jeng Tyng; Goncalves, Marcelo [Hospital do Cancer de Sao Paulo, SP (Brazil). Dept. de Imagem; Dib, Luciano L. [Hospital do cancer de Sao Paulo, SP (Brazil). Dept. de Estomatologia

    1999-06-01

    The radiolucent lesions of the maxilla and jaw can present similar features, such as location, proximity or dental inclusion, insufflative character and density. They are so alike that those signs frequently are not enough for the diagnosis. Among those lesions, we present follicular cysts, ameloblastomas, odontogenic keratocysts, central giant cell lesion, neurofibroma, mucoepydermoid carcinoma and hemangioma, examined with panoramic X-rays, computed tomography and in a specific case, a SPECT for the jaw, with red blood cells-{sup 99m} Tc. The objective of this work is to demonstrate in a illustrative way, the radiographic features of some of the radiolucent lesions of the maxilla and jaw, whose differential diagnosis becomes sometimes very difficult, but can be achieved through signs that are more compatible with certain lesions. (author)

  4. DOS: the discrete-ordinates system

    International Nuclear Information System (INIS)

    The Discrete Ordinates System determines the flux of neutrons or photons due either to fixed sources specified by the user or to sources generated by particle interaction with the problem materials. It also determines numerous secondary results which depend upon flux. Criticality searches can be performed. Numerous input, output, and file manipulation facilities are provided. The DOS driver program reads the problem specification from an input file and calls various program modules into execution as specified by the input file

  5. Dos nuevos puentes ligeros, en Alemania

    Directory of Open Access Journals (Sweden)

    Bay, Hermann

    1961-03-01

    Full Text Available Las dos obras, objeto de ligera descripción en este trabajo, dan patentes muestras de las direcciones generales en el orden constructivo hacia la belleza, esbeltez y función específica, objeto éste, que ha de cubrir las exigencias de la explotación pública, en este caso, de la obra.

  6. Defesa dos direitos humanos: sistemas regionais

    Directory of Open Access Journals (Sweden)

    Hélio Bicudo

    2003-04-01

    Full Text Available O texto discorre sobre a institucionalização dos sistemas de promoção dos Direitos Humanos, ao longo do século XX. Tomando a Declaração Universal dos Direitos do Homem, de 1948, como base e ponto de partida, o articulista aborda as três principais vertentes dos sistemas de promoção desses direitos: a européia, a americana e a africana. A evolução de cada uma delas descrita analógica e epistemologicamente, de forma a salientar singularidades sem perder de vista as influências recíprocas ou mesmo as determinantes próprias do contexto espaço-social. Para finalizar, o articulista destaca a importância do Tribunal Penal Internacional no estabelecimento de uma justiça ecumênica. Concomitantemente, alerta para o perigo contido na ameaça de os EUA não o ratificarem.The text underlines the institutional character acquired by the main systems to promote Human Rights in the twentieth century. Taking the Universal Human Rigths Declaration, of 1948, as the basis for analysis, the author brings up three different approaches to promote these rights: the European, the American and the African. The evolution of each of them is described using its procedure as a basic reference. Besides, an analogical analysis, brings to the fore singularities, without ignoring reciprocal influences dictated by particular contexts, though. The author stresses the importance of the International Penal Court, as a means to establish ecumenical justice. At the same time, he reminds the reader of the risks implicit in the possible non-ratification of the IPC by United States.

  7. Targeted tumor radiotherapy

    Directory of Open Access Journals (Sweden)

    Unak Perihan

    2002-01-01

    Full Text Available Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications more progress is still needed. In this article, the potential use of targeted tumor radiotherapy is briefly reviewed. More general aspects and considerations, such as potential radionuclides, mechanisms of tumor targeting was also outlined.

  8. Bone tumors: Nursing care

    International Nuclear Information System (INIS)

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  9. Pulmonary neuroendocrine (carcinoid) tumors

    DEFF Research Database (Denmark)

    Caplin, M E; Baudin, E; Ferolla, P;

    2015-01-01

    carried out in PubMed for the terms 'pulmonary neuroendocrine tumors', 'bronchial neuroendocrine tumors', 'bronchial carcinoid tumors', 'pulmonary carcinoid', 'pulmonary typical/atypical carcinoid', and 'pulmonary carcinoid and diagnosis/treatment/epidemiology/prognosis'. A systematic review...... of the relevant literature was carried out, followed by expert review. RESULTS: PCs are well-differentiated neuroendocrine tumors and include low- and intermediate-grade malignant tumors, i.e. typical (TC) and atypical carcinoid (AC), respectively. Contrast CT scan is the diagnostic gold standard for PCs......, but pathology examination is mandatory for their correct classification. Somatostatin receptor imaging may visualize nearly 80% of the primary tumors and is most sensitive for metastatic disease. Plasma chromogranin A can be increased in PCs. Surgery is the treatment of choice for PCs with the aim of removing...

  10. Dentinogenic ghost cell tumor

    Directory of Open Access Journals (Sweden)

    Singhaniya Shikha

    2009-01-01

    Full Text Available Dentinogenic ghost cell tumor (DGCT is a rare tumorous form of calcifying odontogenic cyst and only a small number of cases have been described. It is a locally invasive neoplasm that is characterized by ameloblastoma-like epithelial islands, ghost cells and dentinoid. The present report describes a case of a 21-year-old male with a tumor in the posterior region of the mandible, showing features of DGCT.

  11. Percutaneous Bone Tumor Management

    OpenAIRE

    Gangi, Afshin; Buy, Xavier

    2010-01-01

    Interventional radiology plays a major role in the management of bone tumors. Many different percutaneous techniques are available. Some aim to treat pain and consolidate a pathological bone (cementoplasty); others aim to ablate tumor or reduce its volume (sclerotherapy, thermal ablation). In this article, image-guided techniques of primary and secondary bone tumors with vertebroplasty, ethanol injection, radiofrequency ablation, laser photocoagulation, cryoablation, and radiofrequency ioniza...

  12. Adenomatoid Tumor of Testis

    OpenAIRE

    Amin, Waqas; Parwani, Anil V

    2009-01-01

    Adenomatoid tumors are responsible for 30% of all paratesticular masses. These are usually asymptomatic, slow growing masses. They are benign tumors comprising of cords and tubules of cuboidal to columnar cells with vacuolated cytoplasm and fibrous stroma. They are considered to be of mesothelial origin supported by histochemical studies and genetic analysis of Wilms tumor 1 gene expression. Excision biopsy is both diagnostic and therapeutic procedure. The main clinical consideration is accur...

  13. Olfactory ensheathing cell tumor

    Directory of Open Access Journals (Sweden)

    Ippili Kaushal

    2009-01-01

    Full Text Available Olfactory ensheathing cells (OECs are found in the olfactory bulb and olfactory nasal mucosa. They resemble Schwann cells on light and electron microscopy, however, immunohistochemical staining can distinguish between the two. There are less than 30 cases of olfactory groove schwannomas reported in the literature while there is only one reported case of OEC tumor. We report an OEC tumor in a 42-year-old male and discuss the pathology and origin of this rare tumor.

  14. ADRENOCORTICAL TUMORS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Kannepalli

    2015-08-01

    Full Text Available Adrenocortical tumors rare in children which are 0.2% of all Pediatric neoplasms. These are mostly Occurs less than 10 yrs. Most of pediatric ( E ndogenous Cushing's syndrome cases are caused by adrenocortical carcinomas and 20 - 40% of adrenocortical tumors have Cushing syndrome in addition to virilization. In present study we have treated 5 patients of adrenocortical tumors. All are left sided functional benign adrenocortical adenoma except one ( C arcinoma . After resection of Tumors the clinical Features of Cushing’s & Hypertension were subsided.

  15. Brain tumor - children

    Science.gov (United States)

    Glioblastoma multiforme - children; Ependymoma - children; Glioma - children; Astrocytoma - children; Medulloblastoma - children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children)

  16. Tumor cell metabolism

    Science.gov (United States)

    Romero-Garcia, Susana; Lopez-Gonzalez, Jose Sullivan; B´ez-Viveros, José Luis; Aguilar-Cazares, Dolores

    2011-01-01

    Cancer is a genetic disease that is caused by mutations in oncogenes, tumor suppressor genes and stability genes. The fact that the metabolism of tumor cells is altered has been known for many years. However, the mechanisms and consequences of metabolic reprogramming have just begun to be understood. In this review, an integral view of tumor cell metabolism is presented, showing how metabolic pathways are reprogrammed to satisfy tumor cell proliferation and survival requirements. In tumor cells, glycolysis is strongly enhanced to fulfill the high ATP demands of these cells; glucose carbons are the main building blocks in fatty acid and nucleotide biosynthesis. Glutaminolysis is also increased to satisfy NADPH regeneration, whereas glutamine carbons replenish the Krebs cycle, which produces metabolites that are constantly used for macromolecular biosynthesis. A characteristic feature of the tumor microenvironment is acidosis, which results from the local increase in lactic acid production by tumor cells. This phenomenon is attributed to the carbons from glutamine and glucose, which are also used for lactic acid production. Lactic acidosis also directs the metabolic reprogramming of tumor cells and serves as an additional selective pressure. Finally, we also discuss the role of mitochondria in supporting tumor cell metabolism. PMID:22057267

  17. O mundo dos bens, vinte anos depois

    Directory of Open Access Journals (Sweden)

    Mary Douglas

    2007-12-01

    Full Text Available A partir do anúncio da reedição de seu livro O Mundo dos Bens, publicado originalmente em 1979, a autora faz uma reflexão do contexto intelectual em que sua obra foi fundamentada. Ela discute as bases da importância do estudo do consumo para a economia e para a antropologia, salientando que isso pode contribuir para alcançar o projeto de "totalidade" dos fenômenos sociais, na perspectiva de Marcel Mauss - autor que teve grande influência para O Mundo dos Bens. O artigo ainda mostra trabalhos e debates clássicos sobre o tema das trocas que contribuíram para as reflexões desenvolvidas no livro. É retomado o argumento de que a pobreza deve ser entendida como um processo de exclusão de informação e, nesse sentido, a autora expõe porque o estudo sobre o consumo é de grande valia para a antropologia.Taking into account the announcement of the re-edition of her book The World of Goods, originally published in 1979, the author develops a reflection on the intellectual context in which her work was created. She discusses the bases of the importance of Consumption Studies for Economics and Anthropology, suggesting that they help to attain the project of "totality" in the study of social phenomena, following the notion of Marcel Mauss - an author who exerted a great influence in the The World of Goods. The article also analyses classical works and discussions about exchanges that contributed to the reflections developed in the book. She resumes her central point, that is, that poverty must be understood as a process concerning the exclusion of information. In this sense, she presents the reasons the study on consumption is of great value for Anthropology.

  18. Silvina Ocampo: la vejez en dos tiempos

    OpenAIRE

    Mancini, Adriana

    2004-01-01

    El presente artículo aborda la representación de la vejez y la muerte en dos momentos de producción de la obra de Silvina Ocampo. La configuración y el comportamiento de ciertos personajes de una serie de cuentos de Viaje olvidado (1937), La furia y otros cuentos (1959) y Los días de la noche (1970) manifiestan aspectos constitutivos de la vejez; por su parte, los últimos textos de Cornelia frente al espejo (1988) presentan la conflictiva relación entre el viejo, su vejez y la muerte.

  19. Por uma carta dos bens fundamentais

    Directory of Open Access Journals (Sweden)

    Luigi Ferrajoli

    2010-07-01

    Full Text Available Este artigo questiona a possibilidade de a estipulação dos direitos fundamentais, e suas obrigações e proibições correspondentes, ser suficiente para garantir adequadamente as necessidades e os interesses vitais, em especial aqueles de interesse coletivo. São bens fundamentais aqueles cujo acesso é garantido a todos e a cada um, visto que são objetos dos direitos fundamentais subtraídos à lógica do mercado. A garantia de novos bens como bens fundamentais exige uma decisão política civilizatória de submeter ao direito as relações de mercado. Assim, às cartas e convenções internacionais e constitucionais de direitos fundamentais deveriam ser acrescentadas Cartas Constitucionais e Cartas Internacionais de bens fundamentais. Daí a necessidade de uma nova dimensão do constitucionalismo garantista: a longo prazo, além de global, para além da lógica individualista dos direitos e da miopia, e do estreito localismo da política das democracias nacionais.AbstractThis article addresses the question of whether the stipulation of fundamental rights and obligations and prohibitions related to them is sufficient to properly ensure the needs and vital interests, especially those from collective interest. Fundamental goods are those whose access is guaranteed to each and every one since they are the object of fundamental rights, excluded from the logic of the market. The warranty for new goods and basic goods in the bottom of civilization requires a political decision to submit the right market relations. Thus, to the international charters and conventions and fundamental constitutional rights should be added Charters and international charter of basic goods. Hence the need for a new dimension of the constitutionally guaranteed: a constitutionally guaranteed in the long term, and global, apart from the individualistic logic of rights and shortsightedness and narrow localism policy of national democracies.

  20. Lista dos Anelídeos (Annelida)

    OpenAIRE

    Paulo A V Borges

    2010-01-01

    A diversidade das minhocas (Annelida) é aqui compilada, em adição aos grupos de animais terrestres listados em detalhe noutros capítulos deste livro (Platyhelminthes, Nematoda, Mollusca, Arthropoda, Chordata). Com base na recente lista de espécies animais terrestres da Europa, projecto “Fauna Europaea” (http:// www.faunaeur.org), listam-se 21 espécies de anelí deos terrestres. É apresentada a distribuição das espécies ou subespécies nas nove ilhas dos Açores, usando-se a seguinte simbologia: ...

  1. Sobre a peleja dos sujeitos da reforma, ou da reforma dos sujeitos em peleja

    Directory of Open Access Journals (Sweden)

    Gastão Wagner de Sousa Campos

    1992-01-01

    Full Text Available O presente trabalho analisa os principais impasses da reforma sanitária brasileira, bem como avalia a atuação do movimento de saúde a nível das instituições. Aplicando à saúde conceitos de Gramsci, F. Guattari e Castoriadis, com o objetivo de identificar os processos de construção da subjetividade dos trabalhadores de saúde, propõe-se caminhos para a reforma dos sujeitos sociais nas práticas de saúde e como atores de um processo político de reforma.

  2. Lista preliminar dos Nematoda, Annelida e Chordata terrestres dos Açores

    OpenAIRE

    Paulo A V Borges

    2005-01-01

    Apresenta-se uma lista preliminar dos Filos Nematoda, Annelida e Chordata terrestres dos Açores. Com base na recente lista de espécies animais terrestres da Europa, projecto “Fauna Europaea” (http://www.faunaeur.org), listam-se 80 espécies de nemátodos e 21 espécies de anelídeos terrestres. As cerca de 49 espécies de vertebrados (Chordata) listados correspondem às espécies que se reproduzem nos Açores. ABSTRACT: A preliminary list of the Phyla Nematoda, Annelida and Chordata was compiled. ...

  3. Tumor-Targeted Nanomedicines

    Science.gov (United States)

    ElBayoumi, Tamer A.; Torchilin, Vladimir P.

    2009-01-01

    Purpose The efficacy of drug delivery systems can be enhanced by making them target-specific via the attachment of various ligands. We attempted to enhance tumor accumulation and therapeutic effect of doxorubicin-loaded long-circulating PEGylated liposomes (Doxil®, ALZA Corp.) by coupling to their surface the anti-cancer monoclonal antibody 2C5 (mAb 2C5) with nuclesome (NS)-restricted activity, that can recognize the surface of various tumor but not normal cells and specifically targets pharmaceutical carriers to tumor cells in vitro and in vivo. Following earlier in vitro results with various cancer cell lines, the mAb 2C5-liposomes were studied in vivo vs. plain and non-specific IgG-liposomes. Experimental design Antibody coupling to Doxil® was performed via the “post-insertion” technique. Using 111In-labeled liposomes, the tissue biodistribution and pharmacokinetic profile were studied, as well as their accumulation in tumors in mice was followed by the whole-body γ-scintigraphic imaging. Therapeutic efficacy of mAb 2C5-targeted Doxil® vs. non-specific IgG-modified and original Doxil® controls was followed by registering live tumor growth and determining tumor weights upon mice sacrifice. Results mAb2C5 antibody-targeted liposomes demonstrate enhanced accumulation in tumors, and the in vivo therapeutic activity of the mAb 2C5-Doxil® treatment was found to be significantly superior, resulting in final tumor weights of only 25-40% compared to all Doxil® control treatments, when tested against the subcutaneous primary murine tumors of 4T1 and C26 and human PC3 tumor in nude mice. Conclusions Our results demonstrate the remarkable capability of 2C5-targeted Doxil® to specifically deliver its cargo into various tumors significantly increasing the efficacy of therapy. PMID:19276264

  4. Renal inflammatory myofibroblastic tumor

    DEFF Research Database (Denmark)

    Heerwagen, S T; Jensen, C; Bagi, P;

    2007-01-01

    Renal inflammatory myofibroblastic tumor (IMT) is a rare soft-tissue tumor of controversial etiology with a potential for local recurrence after incomplete surgical resection. The radiological findings in renal IMT are not well described. We report two cases in adults with a renal mass treated...

  5. Vanishing tumor in pregnancy

    Directory of Open Access Journals (Sweden)

    M V Vimal

    2012-01-01

    Full Text Available A patient with microprolactinoma, who had two successful pregnancies, is described for management issues. First pregnancy was uneventful. During the second pregnancy, the tumor enlarged to macroprolactinoma with headache and blurring of vision which was managed successfully with bromocriptine. Post delivery, complete disappearance of the tumor was documented.

  6. [Prognosis in tumor diagnosis].

    Science.gov (United States)

    Bruns, G

    1983-01-01

    This essay on prognosis in tumor diagnosis pathology resp. tumor etiology, cancerogenesis and molecular oncology is the authors personal opinion. Generally tumor diagnosis improves with progress in histo- and cytological methods for example in tumors of the APUD-system and precancerous lesions especially of the breast. Fundamental principle of developed tumor diagnosis is the knowledge of malignant transformation. Its profits favours the etiology in cancerogenesis and e.g. non Hodgkin lymphomas (Burkitt lymphoma, adult T-cell lymphoma) and to result from new methods in molecular biology and viral genetics (DNS-hybridizing, -recombination and gene technology). With the beginning century a stepwise fitted diagnosis of malignant lymphomas is evident up to monoclonal dedifferentiated lymphoid cells and their multifarious phenotypical markers. This concept may be of general significance in tumor diagnosis already indicated in prelymphomas. Finally the present prognosis of tumor diagnosis is evaluated by contents, tasks and strategies of its corresponding research lines in clinical and experimental tumor pathology resp. its organization.

  7. What Is Wilms Tumor?

    Science.gov (United States)

    ... back wall of the abdomen (see picture). Each kidney is about the size of a fist. One kidney is just to ... functions. Many people in the United States live normal, healthy lives with just one kidney. Wilms tumors Wilms tumors are the most common ...

  8. [Circulating "tumor markers" in gastrointestinal tumors].

    Science.gov (United States)

    Borlinghaus, P; Lamerz, R

    1991-09-01

    Tumor markers (TM) of the neoplastic cell can be divided into non-shedded substances and antigens shedded in blood, urine or other body fluids. For clinicians circulating TM are more important. All relevant circulating TM are not useful in screening of asymptomatic patients because of insufficient sensitivity and specificity. With caution they are useful in the observation of risk groups. Circulating TM have their main significance as additional parameters in monitoring symptomatic patients with malignancies. Several follow up determinations are more important than one single measurement. During follow up of tumor patients TM should not be checked automatically if there are no diagnostic or therapeutical consequences. The clinically most important circulating TM in non-hormone secreting tumors of the gastrointestinal tract are the oncofetal antigens CEA and AFP and antigens defined by monoclonal antibodies e. g. CA 19-9 and CA 72-4. AFP is the primary TM in hepatocellular carcinoma, often elevated in hepatoblastoma and always normal in cholangiocellular carcinoma. CEA is the TM of first choice in patients with colorectal carcinomas and liver metastasis. CA 19-9 is TM of first choice in pancreatic carcinoma and additionally of diagnostic value in cholangiocellular carcinoma and tumors of the bile ducts. In cancer of the stomach CA 19-9 and CEA are secondary TM in combination with CA 72-4 as primary TM. Care should be taken that slight and moderate elevations of TM can be observed in benign diseases of liver, pancreas and bowel.

  9. Gastrointestinal carcinoid tumors Tumores carcinoides digestivos

    Directory of Open Access Journals (Sweden)

    M. J. Varas Lorenzo

    2010-09-01

    Full Text Available Objective: carcinoid tumors (CTs represent the commonest neuroendocrine tumors. Those in the gastrointestinal tract are diagnosed in surgical specimens, clinically, and using imaging techniques (endoscopy, echoendoscopy, CT, Octreoscan, etc.. The goal of this retrospective study was to review a personal series of gastrointestinal carcinoid tumors, and to compare it to those in the literature. Patients and methods: the medical records of 40 Caucasian patients with over 50 gastrointestinal carcinoid tumors (including multiple cases who were seen for a period of 16 years (1994-2009 were reviewed. Results: mean age at presentation was 52 years, 50% were females, and mean tumor size was 9.9 mm. Most were gastroduodenal (42.5% or rectal (30%, and were treated endoscopically. Metastases and carcinoid syndrome (CS were seen in 5% of patients. Survival at study endpoint was 85%. Conclusions: age and gender were consistent with the literature. There was an increase in gastroduodenal (multifocal and rectal carcinoids, likely because the series was essentially endoscopical in nature (bias. There was a lower rate of CS and higher survival, likely due to earlier diagnosis and treatment.Objetivo: los tumores carcinoides (TC son los tumores neuroendocrinos más frecuentes. Los digestivos se diagnostican en las piezas quirúrgicas, en la clínica, y mediante los métodos de imagen (endoscopia, ecoendoscopia, TAC y Octreoscan, etc.. El objetivo de este trabajo retrospectivo fue revisar una serie personal de tumores carcinoides digestivos y compararla con la literatura. Pacientes y métodos: se revisaron las historias clínicas de 40 pacientes de raza blanca con más de 50 tumores carcinoides digestivos, algunos múltiples, observados durante 16 años (1994-2009. Resultados: la edad media de presentación fue 52 años, 50% mujeres, con un tamaño medio del tumor de 9,9 mm. La mayoría eran gastroduodenales (42,5% y rectales (30% y fueron tratados por vía endosc

  10. Iatrogenic Tumor Implantation

    Institute of Scientific and Technical Information of China (English)

    Ying Ma; Ping Bai

    2008-01-01

    Iatrogenic tumor implantation is a condition that results from various medical procedures used during diagnosis or treatment of a malignancy. It involves desquamation and dissemination of tumor cells that develop into a local recurrence or distant metastasis from the tumor under treatment. The main clinical feature of the condition is nodules at the operation's porous channel or incision, which is easily diagnosed in accordance with the case history. Final diagnosis can be made based on pathological examination. Tumor implantation may occur in various puncturing porous channels, including a laparoscopic port, abdominal wall incision, and perineal incision, etc. Besides a malignant tumor,implantation potential exists with diseases, such as a borderline tumor and endometriosis etc. Once a tumor implantation is diagnosed, or suspected, surgical resection is usually conducted.During the diagnosis and treatment of diseases, avoiding and reducing iatrogenic implantation and dissemination has been regarded as an important principle for surgical treatment of tumors. In a clinical practice setting, if possible, excisional biopsy should be employed, if a biopsy is needed. Repeated puncturing should be avoided during a paracentesis. In a laparoscopic procedure, the tissue is first put into a sample bag and then is taken out from the point of incision. After a laparoscopic procedure, the peritoneum, abdominal muscular fasciae, and skin should be carefully closed, and/or the punctured porous channel be excised. In addition, the sample/tissue should be rinsed with distilled water before surgical closure of the abdominal cavity,allowing the exfoliated tumor cells to swell and rupture in the hypo-osmolar solution. Then surgical closure can be conducted following a change of gloves and equipment. The extent of hysteromyomectomy should as far as possible be away from the uterine cavity. The purpose of this study is to make clinicians aware of the possibility of tumor implantation

  11. Trabalho em saúde mental: vivências dos profissionais diante dos resultados

    Directory of Open Access Journals (Sweden)

    Vinicius Carvalho de Vasconcellos

    2012-12-01

    Full Text Available Considerando o cenário de consolidação da reforma psiquiátrica brasileira, este artigo investigou, no contexto dos trabalhadores da saúde mental, representações relativas ao papel profissional, às vivências diante dos resultados da assistência e às expectativas do futuro profissional da Saúde, tratando igualmente da possível ligação entre esses elementos. O material empírico foi coletado por meio de oito entrevistas semiestruturadas, realizadas em um Centro de Atenção Psicossocial brasileiro, e analisado principalmente pelo referencial teórico da psicossociologia francesa. De modo geral, os resultados sugerem que a vivência de realização diante dos resultados do trabalho vincula-se ao cumprimento do papel profissional, indicando também a ligação entre esses últimos elementos e as expectativas do futuro profissional. Na discussão e nas considerações finais, ressalta-se a concepção do trabalho por meio de seus limites intrínsecos como mecanismo que atenua a frustração profissional e analisam-se as implicações das vivências relativas aos resultados no vínculo subjetivo dos profissionais com o trabalho.

  12. PERFIL DO COMPORTAMENTO GERENCIAL: UM ESTUDO DE CASO DOS DIRETORES DOS CENTROS DE ENSINO DA UFSM

    Directory of Open Access Journals (Sweden)

    Daniela Huppes

    2009-12-01

    Full Text Available Com o aumento das pesquisas acerca de como deve ser um líder capaz de levar sua organização para níveis mais altos de eficiência, o presente trabalho objetiva identificar o perfil de comportamento gerencial, de acordo com o modelo proposto por Yukl (1998, dos Diretores de Centro da Universidade Federal de Santa Maria (UFSM. Utilizando a metodologia qualitativa, de caráter descritivo, a pesquisa foi realizada através de entrevistas semi-estruturadas, aplicadas a cada um dos oito Diretores dos Centros de Ensino. A análise dos dados foi realizada pela análise de conteúdo. Os resultados demonstram um perfil gerencial desses Diretores muito ligado ao gerenciamento de tarefas, devido à estrutura burocrática da própria instituição. Assim, atividades como planejar, solucionar problemas, administrar conflitos e esclarecer papéis e objetivos, atendidos pela exigência da universidade, e atividades relacionadas a formas de administrar relações, como monitorar desempenho, acaba negligenciado.

  13. ACERCA DOS PROCESSOS DE INDIGENIZAÇÃO DOS MUSEUS: UMA ANÁLISE COMPARATIVA

    Directory of Open Access Journals (Sweden)

    Andrea Roca

    2015-04-01

    Full Text Available A partir de uma leitura comparativa sobre a agência indígena no Museu Magüta (primeiro museu indígena do Brasil, pertencente ao povo Ticuna, localizado em Benjamin Constant, Amazonas e nas mostras do povo Musqueam no Museu de Antropologia da University of British Columbia (pioneiro na implementação do trabalho colaborativo com os povos indígenas, localizado em Vancouver, Canadá, este trabalho aborda modalidades coexistentes da chamada indigenização dos museus. Interessa-me distinguir as epistemologias e as políticas envolvidas na construção dos conteúdos indígenas desses espaços e sua autorrepresentação, problematizando a expressão "indigenização dos museus" e refletindo, ao mesmo tempo, sobre aquilo que se reconstrói, em termos dos cenários museológicos, após as situações coloniais

  14. THE TUMOR MACROENVIRONMENT: CANCER-PROMOTING NETWORKS BEYOND TUMOR BEDS

    Science.gov (United States)

    Rutkowski, Melanie R.; Svoronos, Nikolaos; Puchalt, Alfredo Perales; Conejo-Garcia, Jose R.

    2015-01-01

    During tumor progression, alterations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion to distal organs, and eventual metastatic disease. Distally produced hormones, commensal microbiota residing within mucosal surfaces, and myeloid cells and even the bone marrow impact the systemic immune system, tumor growth, and metastatic spread. Understanding the reciprocal interactions between the cells and soluble factors within the macroenvironment and the primary tumor will enable the design of specific therapies that have the potential to prevent dissemination and metastatic spread. This chapter will summarize recent findings detailing how the primary tumor and systemic tumor macroenvironment coordinate malignant progression. PMID:26216635

  15. Tumor endometrioide borderline de ovário em adolescente: relato de caso Borderline ovarian endometrioid tumor in adolescent: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Tamara Carvalho dos Santos

    2010-04-01

    Full Text Available Os tumores endometrioides malignos ovarianos são neoplasias epiteliais raras em pacientes jovens. Enquanto os carcinomas endometrioides ovarianos acometem mulheres na quinta e na sexta décadas de vida, os tumores borderline acometem mulheres em uma faixa etária mais ampla (de 22 a 77 anos. Descreveremos a seguir um caso raro de tumor endometrioide borderline ocorrendo em paciente de 16 anos. Desde que tumores do saco vitelino (TSV e de Sertoli-Leydig (TCSL podem mimetizar morfologicamente tumor endometrioide, o uso da imuno-histoquímica, além dos aspectos morfológicos, foi fundamental para estabelecer o diagnóstico diferencial entre essas condições.Malignant endometrioid ovarian tumors are rare epithelial neoplasias among young patients. Whereas endometrioid ovarian carcinomas are more common among women in their fifth and sixth decades of life, borderline endometrioid tumors affect 22 to 77 year-old women. The present study reports a rare case of borderline endometrioid tumor in a 16 year-old patient. Since yolk sac and Sertoli-Leydig cell tumor may morphologically mimic endometrioid tumor, both the use of immunohistochemistry and morphological aspects were essential to establish the differential diagnosis.

  16. The management of parotid tumors

    Institute of Scientific and Technical Information of China (English)

    Guang Yan Yu

    2008-01-01

    @@ The majority of salivary gland tumors are of epithelial origin. Parotid gland is the most common location of the tumors. Surgery is the main modality for the management of parotid tumors. Radiotherapy, chemotherapy etc are the auxiliary modalities.

  17. Scintiscans and carcinoid tumors

    International Nuclear Information System (INIS)

    The presence of somatostatin receptors on carcinoid tumors mediate imaging of tumor extent and inhibition of tumor's marker secretion and growth. This prospective study aimed to evaluate radiolabelled somatostatin analogues scans in the therapeutical work-up of carcinoids. Twenty-one patients with carcinoids underwent 26 scans with iodine octreotide or indium pentetreotide. The results for tumor and metastase imaging were analysed and compared to those of a short inhibition test of marker secretion and to those of MIBG scan. The sensitivity for imaging the overall 43 tumor sites was 72%. We had no false positive. Unknown tumors were discovered in three patients. The results were slightly better with indium pentetreotide and in metastase imaging. A positive scan did not always preclude responsiveness to the functional effect of octreotide. Results of somatostatin analogue scans were better than those with MBG. The two techniques showed complementary in one patient. Treatment decision making in patients with carcinoid tumors should benefit from functional inhibition test by octreotide as well as from indium pentreotide and MIBG scans. (authors). 21 refs., 2 figs., 1 tab

  18. Intraaxial brain tumors

    International Nuclear Information System (INIS)

    The incidence of primary intracranial tumors in the United States is approximately 15,0000 new cases per year. It has been estimated that 80--85% of all intracranial tumors occur in adults; the majority are situated in the supratentorial compartment. In the pediatric population, intracranial tumors are extraordinarily common---the CNS is the second most common site of pediatric neoplasia. Excluding the first year of life and adolescence, the location of intracranial tumors in the pediatric age group is infratentorial in 60--70% of cases, of which 75% involve the cerebellum and 25% reside in the brainstem. The limitations of neuroimaging are often revealed by understanding the microscopic pathology of these lesions, just as the neuropathologist would find if he or she relied solely on gross pathology. The general correlation between pathology and imaging will be stressed in this paper. Innumerable schemes for tumor classification have been devised; unfortunately, no classification is perfect. For the purposes of this discussion, the author has modified the proposed classifications of tumors in an attempt to combine typical neuroanatomic sites with the complex divisions traditionally formed on the basis of histopathology, since it is well recognized that the clinical behavior of brain tumors can depend largely on their sites of origin

  19. Central nervous system tumors

    International Nuclear Information System (INIS)

    Central nervous system (CNS) tumors are relatively common in veterinary medicine, with most diagnoses occurring in the canine and feline species. Numerous tumor types from various cells or origins have been identified with the most common tumors being meningiomas and glial cell tumors. Radiation therapy is often used as an aid to control the clinical signs associated with these neoplasms. In general, these tumors have a very low metastatic potential, such that local control offers substantial benefit. Experience in veterinary radiation oncology would indicate that many patients benefit from radiation treatment. Current practice indicates the need for computed tomography or magnetic resonance imaging studies. These highly beneficial studies are used for diagnosis, treatment planning, and to monitor treatment response. Improvements in treatment planning and radiation delivered to the tumor, while sparing the normal tissues, should improve local control and decrease potential radiation related problems to the CNS. When possible, multiple fractions of 3 Gy or less should be used. The tolerance dose to the normal tissue with this fractionation schedule is 50 to 55 Gy. The most common and serious complications of radiation for CNS tumors is delayed radiation myelopathy and necrosis. Medical management of the patient during radiation therapy requires careful attention to anesthetic protocols, and medications to reduce intracranial pressure that is often elevated in these patients. Canine brain tumors have served as an experimental model to test numerous new treatments. Increased availability of advanced imaging modalities has spawned increased detection of these neoplasms. Early detection of these tumors with appropriate aggressive therapy should prove beneficial to many patients

  20. Contabilidade criativa e responsabilidade dos auditores

    Directory of Open Access Journals (Sweden)

    Ariovaldo dos Santos

    2003-08-01

    Full Text Available Nos contextos nacional e internacional da profissão contábil, o auditor tem exercido um papel fundamental. A atividade profissional do auditor independente tem ajudado a impulsionar o desenvolvimento dos mercados, além de contribuir para o estabelecimento da ordem socioeconômica mundial. Na visão dos usuários externos da informação contábil, e dos próprios clientes, a atuação do auditor é sinônimo de confiança e credibilidade. Nos últimos meses, a onda de escândalos contábeis, com grandes empresas de auditoria envolvidas, e até sentenciadas (no caso Enron, a Andersen foi considerada culpada, por um Júri de Houston - Texas, pela destruição de documentos, marcou a atividade profissional dos auditores e parece ter mudado a visão de responsabilidade desses profissionais sobre esses fatos. No presente artigo são estudados e apresentados alguns conceitos fundamentais relacionados com o fenômeno da contabilidade criativa, assim como os fatores que induzem sua utilização, dentre os quais pode-se destacar: valores éticos, morais e vácuos ou flexibilidade normativa. Tais fatores acabam por funcionar como catalisadores da engenharia contábil no desenho das demonstrações contábeis e passam a atender os interesses de quem as elabora em vez de buscar a imagem fidedigna do patrimônio.In the national and international contexts of professional accounting, the auditor has played a fundamental role. The professional activity of the independent auditor has both helped to encourage market development and contributed to the establishment of a global socio-economic order.From the point of view of the external users of accounting information and the clients themselves, the professional activity of the auditor is a synonym of trust and credibility. In the last few months, the wave of financial scandals involving large auditing companies, some of which were even convicted for their demonstrated - direct and indirect - intervention in

  1. Panorama dos cursos de agroecologia no Brasil.

    OpenAIRE

    Balla, João Vitor Quintas; Massukado, Luciana Miyoko; Pimentel, Vania Costa

    2014-01-01

    Os cursos de agroecologia têm crescido nos últimos anos e sua introdução nas instituições de ensino se deu, em especial, a partir dos anos 2000. Desde então, diversos cursos são criados anualmente. No entanto, são poucos e dispersos os estudos que realizam uma análise quantitativa sistematizada sobre o ensino da agroecologia no Brasil. O objetivo deste estudo foi identificar os cursos em agroecologia, no âmbito da educação formal, que estão em funcionamento no Brasil, por região geográfica e ...

  2. SURVIVIN AND TUMOR

    Institute of Scientific and Technical Information of China (English)

    宋文哲; 宋燕; 叶剑桥; 邱东涛

    2003-01-01

    As a new member of IAP (inhibitors of apoptosis protein) family, survivin has potent anti-apoptotic activities, and involves in the mitosis and angiogenesis. Researches have demonstrated that surviving is a tumor-specific anti-apoptotic factor, expressed in fetal tissues, and common human cancers, while not in normal, terminally differentiated adult tissues. The overexpression of survivin in tumor tissues is correlated with poor prognosis of the patients. Survivin can be used as a prognostic factor and a new target in tumor targeting therapy.

  3. Multiple granular cell tumor.

    Science.gov (United States)

    Jones, J K; Kuo, T T; Griffiths, C M; Itharat, S

    1980-10-01

    Eleven cases of granular cell tumor were reviewed. In two of the cases multiple sites of involvement were seen. The tumor occurred in the oral cavity in both of these cases and each was initially wrongly diagnosed as squamous cell carcinoma. The most common site was the subcutaneous tissue (nine patients) and the tongue was involved in three cases. In one patient the parotid gland was involved. Eight of the patients were females and three were males; seven were black and four were white. The importance of differentiating between squamous cell carcinoma and granular cell tumor is stressed, as is the need for a simple wide surgical excision. PMID:7421377

  4. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  5. La larga vida de dos rocas orensanas

    Directory of Open Access Journals (Sweden)

    García Quintela, Marco V.

    2011-12-01

    Full Text Available We study two rocks, a rock carving and a «rocky sanctuary » from the Ourense province (Spain, with two complementary methodologies, landscape archeology and «biography» (Kopytoff of objects. We start with their description in Christian texts, and then we observe that their relation with important hillforts forms a localization pattern, and finally we propose to date that relationship in the Iron Age. This chronology of the rocks and the following Christian reevaluation leads towards their «social life». These analyses are pertinent in the current debate about the chronology of the Galician rock art, and we propose that the use and meaning in the long term is as important as the initial moment of the carving.Se estudian dos rocas, un petroglifo y un «santuario rupestre » de la provincia de Ourense, con dos metodologías complementarias, la arqueología del paisaje y la «biografía» (Kopytoff de los objetos. Partiendo de su descripción en textos cristianos se considera el patrón de localización que conforman en relación con castros importantes, relación que se propone fechar en la Edad del Hierro. Esta adscripción cronocultural y su posterior resemantización cristiana lleva a la consideración de su «vida social». Estas aproximaciones inciden en el debate sobre la datación del arte rupestre en Galicia y se propone que, más allá del momento de grabado inicial, se estudie su uso y sentido en la larga duración.

  6. Experimental model of ultrasound thermotherapy in rats inoculated with Walker-236 tumor Modelo experimental de termoterapia ultrassônica em ratos inoculados com tumor de Walker-236

    Directory of Open Access Journals (Sweden)

    José Antonio Carlos Otaviano David Morano

    2011-01-01

    Full Text Available PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted. Twenty male Wistar rats (160-300 g randomized in 2 equal groups (G-1: Control and G-2: Hyperthermia were inoculated with Walker-256 carcinosarcoma tumor. After 5 days G-2 rats were submitted to 45ºC hyperthermia. Heat was delivered directly to the tumor by an ultrasound (US equipment (3 MHz frequency, 1,5W/cm³. Tumor temperature reached 45º C in 3 minutes and was maintained at this level for 5 minutes. Tumor volume was measured on days 5, 8, 11, 14 e 17 post inoculation in both groups. Unpaired t-test was used for comparison. POBJETIVO: Desenvolver um modelo para avaliar os efeitos do ultra-som focal pulsado como fonte de calor para o tratamento de tumores de Walker subcutâneos implantados em ratos. MÉTODOS: Um estudo experimental, controlado, comparativo foi realizado. Vinte ratos Wistar machos (160-300 g divididos em dois grupos (G-1: Controle e G-2: hipertermia foram inoculados com tumor de Walker carcinossarcoma-256. Após cinco dias os ratos do grupo G-2 ratos foram submetidos a hipertermia (45ºC. O calor foi aplicado diretamente no tumor por um equipamento de ultrassonografia (3 MHz, 1,5 W/cm³. A temperatura no tumor atingiu 45ºC em 3 minutos e foi mantida nesse nível por 5 minutos. O volume do tumor foi medido nos dias 5, 8, 11, 14 e 17 após a inoculação, em ambos os grupos. Teste t não pareado foi utilizado para comparação. P <0,05 foi considerado significante. RESULTADOS: O volume do tumor foi significativamente maior no 5º dia e diminuiu nos dias 11, 14 e 17 nos ratos tratados. Animais submetidos à hipertermia sobreviveram mais tempo que os animais do grupo controle. No 29º dia após a inoculação do tumor, 40% dos ratos do grupo controle e 77,78% dos ratos tratados com

  7. Conjunctival tumors in children: histopathologic diagnosis in 165 cases

    Directory of Open Access Journals (Sweden)

    Martin A. Zimmermann-Paiz

    2015-12-01

    Full Text Available ABSTRACT Purpose: Conjunctival tissue tumors have a varied presentation, and few series studies on pediatric patients have been published. The objective of this paper is to report the histopathologic diagnoses (spanning over 1988-2013 of conjunctival tumors in children younger than 14 years. Methods: We conducted a retrospective, descriptive, and observational study by reviewing the database of all children in whom a conjunctival tumor was surgically removed at Hospital de Ojos y Oídos "Dr. Rodolfo Robles V.," Benemérito Comité Pro Ciegos y Sordos de Guatemala. The data pertaining to gender, age, and histopathologic diagnosis of all cases was collected. The same ocular pathologist made all diagnoses. Results: One hundred sixty-five cases were found, with a mean age of 7.88 years, being 91 (55.15% male subjects. Melanocytic lesions were the most common tumors found (30.91% of cases, with only one case (0.60% being malignant. Conclusions: Melanocytic lesions were the most common tumors found, and of all the cases, only one was malignant; this was in a patient with xeroderma pigmentosum. These findings are consistent with those reported in other studies regarding the frequencies of the histopathology of conjunctival tumors in the pediatric population.

  8. Genetics of adrenal tumors.

    Science.gov (United States)

    Opocher, G; Schiavi, F; Cicala, M V; Patalano, A; Mariniello, B; Boaretto, F; Zovato, S; Pignataro, V; Macino, B; Negro, I; Mantero, F

    2009-06-01

    The impact of genetics and genomics on clinical medicine is becoming more and more important. Endocrinology pioneered the development of molecular medicine, but also the study of adrenal tumors had a great impact in this field. Particularly important was the detection of genetics of tumors derived from the adrenal medulla, as well as that of those derived from the sympathetic and parasympathetic paraganglia. The identification of mutations in one of the several pheochromocytoma/paraganglioma susceptibility genes may indicate a specific clinical management drive. Less well understood is the genetics of adrenal cortex tumors, in particular adrenocortical carcinoma, a rare and particularly aggressive disease. There are only a few examples of hereditary transmission of adrenocortical carcinoma, but the analysis of low penetrance genes by genome wide association study may enable us to discover new genetic mechanisms responsible for adrenocortical-derived tumors. PMID:19471236

  9. Brain Tumor Statistics

    Science.gov (United States)

    ... About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Press Releases Headlines Newsletter ABTA ... About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Careers Brain Tumor Information Brain ...

  10. What Are Pituitary Tumors?

    Science.gov (United States)

    ... too little makes you sluggish. If a pituitary tumor makes too much TSH, it can cause hyperthyroidism (an overactive thyroid gland). Adrenocorticotropic hormone (ACTH, also known as corticotropin ) causes ...

  11. Ovarian tumors secreting insulin.

    Science.gov (United States)

    Battocchio, Marialberta; Zatelli, Maria Chiara; Chiarelli, Silvia; Trento, Mariangela; Ambrosio, Maria Rosaria; Pasquali, Claudio; De Carlo, Eugenio; Dassie, Francesca; Mioni, Roberto; Rebellato, Andrea; Fallo, Francesco; Degli Uberti, Ettore; Martini, Chiara; Vettor, Roberto; Maffei, Pietro

    2015-08-01

    Combined ovarian germ cell and neuroendocrine tumors are rare. Only few cases of hyperinsulinism due to ovarian ectopic secretion have been hypothesized in the literature. An ovarian tumor was diagnosed in a 76-year-old woman, referred to our department for recurrent hypoglycemia with hyperinsulinism. In vivo tests, in particular fasting test, rapid calcium infusion test, and Octreotide test were performed. Ectopic hyperinsulinemic hypoglycemia was demonstrated in vivo and hypoglycemia disappeared after hysteroadnexectomy. Histological exam revealed an ovarian germ cell tumor with neuroendocrine and Yolk sac differentiation, while immunostaining showed insulin positivity in neuroendocrine cells. A cell culture was obtained by tumoral cells, testing Everolimus, and Pasireotide. Insulin was detected in cell culture medium and Everolimus and Pasireotide demonstrated their potentiality in reducing insulin secretion, more than controlling cell viability. Nine cases of hyperinsulinism due to ovarian ectopic secretion reported in literature have been reviewed. These data confirm the ovarian tissue potentiality to induce hyperinsulinemic hypoglycemic syndrome after neoplastic transformation. PMID:25896552

  12. Understanding Brain Tumors

    Science.gov (United States)

    ... Our Mission Advance Research Clinical Trial Endpoints Defeat GBM Oligo Research Fund Pediatric Initiatives Funded Research & Accomplishments ... no symptoms when their brain tumor is discovered Recurrent headaches Issues with vision Seizures Changes in personality ...

  13. Overview of Heart Tumors

    Science.gov (United States)

    ... flow, and has grown into the surrounding tissue, heart transplantation may be required. Transplantation is very rarely done ... and only noncancerous tumors are typically considered for heart transplantation. Mechanical cardiac support might be considered until doctors ...

  14. GASTROINTESTINAL STROMAL TUMOR (GIST

    Directory of Open Access Journals (Sweden)

    Luigi eTornillo

    2014-11-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors of the gastrointestinal tract. The discovery that these tumors, formerly thought of smooth muscle origin, are indeed better characterized by specific activating mutation in genes coding for the receptor tyrosine kinases CKIT and PDGFRA and that these mutations are strongly predictive for the response to targeted therapy with receptor tyrosine kinase inhibitors has made GISTs the typical example of the integration of basic molecular knowledge in the daily clinical activity. The information on the mutational status of these tumors is essential to predict (and subsequently to plan the therapy. As resistant cases are frequently wild-type, other possible oncogenic events, defining other entities, have been discovered (e.g. succinil dehydrogenase mutation/dysregulation, insuline growth factor expression, mutations in the RAS-RAF-MAPK pathway. The classification of disease must nowadays rely on the integration of the clinico-morphological characteristics with the molecular data.

  15. Dinosaurs Got Tumors, Too

    Science.gov (United States)

    ... to the root of the duck-billed dinosaur family tree, and the presence of such a deformity early ... or federal policy. Recent Health News Related MedlinePlus Health Topics Benign Tumors About MedlinePlus Site Map FAQs ...

  16. Dos sentencias distantes y una convención verdadera

    OpenAIRE

    Domenech, Ernesto E.

    2014-01-01

    He aquí dos sentencias, de dos países distintos (Colombia y Argentina), de dos infancias discernibles (una sin padres ni familia al alcance, otra con padres en conflicto y con facebook) de niños y jóvenes de edades diversas (uno de 4 años, otro adolescente). He aquí también dos fueros disímiles (uno penal, el otro civil), con distintos derechos internos y una misma Convención Internacional de Derechos del Niño. La diversidad y la comparación inquietan. El lenguaje claro de las sentencias a...

  17. Antibody tumor penetration

    Science.gov (United States)

    Thurber, Greg M.; Schmidt, Michael M.; Wittrup, K. Dane

    2009-01-01

    Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue. PMID:18541331

  18. Pituitary tumors containing cholecystokinin

    DEFF Research Database (Denmark)

    Rehfeld, J F; Lindholm, J; Andersen, B N;

    1987-01-01

    We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained......'s disease and 7 acromegaly with adenomas containing ACTH. The cholecystokinin peptides from the tumors were smaller and less sulfated than cholecystokinin from normal pituitary glands. We conclude that ACTH-producing pituitary cells may also produce an altered form of cholecystokinin....

  19. Aplicações da teoria dos sistemas à teoria dos códigos

    OpenAIRE

    Rodrigues, Duarte Polónia

    2012-01-01

    Os códigos the Reed Solomon são códigos cíclicos não binários com símbolos de código num corpo de Galois. Eles foram descobertos em 1960 por L. Reed e G. Solomon. Nas décadas após a sua descoberta, os códigos de RS gozaram de inúmeras aplicações. Este trabalho é maioritariamente focado nos algoritmos de codi cação e descodi cação dos códigos RS, analisando uma relação entre a teoria dos códigos e uma técnica de identi cação desenvolvida no âmbito da abordagem comportamental...

  20. A sociedade dos povos como solução dos conflitos internacionais

    Directory of Open Access Journals (Sweden)

    Guilherme Pinto Ravazi

    2015-06-01

    Full Text Available RESUMO O objetivo deste artigo é estabelecer o estado de coisas do problema dos conflitos internacionais. Em seguida, apresentar o projeto iluminista de Kant n’A Paz Perpétua que propõe uma série de princípios para o estabelecimento de uma Federação da Paz. Por fim, expor o projeto de Rawls no Direito dos Povos como uma solução para os conflitos internacionais. ABSTRACT The aim of this paper is to discribe the state of affairs of the issue of international conflicts. Then I present Kant’s Enlightenment project in Perpetual Peace, which proposes a series of principles for the establishment of a pacific federation. Finally, I present Rawls’ project in The Law of Peoples as a solution to international conflicts.

  1. Neurobiologia dos transtornos do controle dos impulsos The neurobiology of impulse control disorders

    Directory of Open Access Journals (Sweden)

    Wendol A Williams

    2008-05-01

    Full Text Available OBJETIVO: Revisar os artigos sobre substratos neurobiológicos dos transtornos do controle dos impulsos. O jogo patológico é o foco central desta revisão na medida em que a maioria dos estudos biológicos dos formalmente classificados como transtornos do controle dos impulsos examinou este transtorno. MÉTODO: Foi feita uma busca no banco de dados Medline de artigos publicados de 1966 até o presente para identificar aqueles relevantes para serem revisados neste artigo. DESFECHOS: Estudos pré-clínicos sugerem que a neuromodulação das monoaminas cerebrais está associada à tomada de decisões impulsivas e aos comportamentos de risco. Os estudos clínicos implicam diversos sistemas de neurotransmissores (serotoninérgico, dopaminérgico, adrenérgico e opióide na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. Estudos de neuroimagem preliminares têm indicado o córtex pré-frontal ventromedial e o estriato ventral como atuantes na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. As contribuições genéticas para o jogo patológico parecem substanciais e os estudos iniciais têm relacionado esse transtorno a polimorfismos alélicos específicos, ainda que os achados de varredura genômica ainda tenham que ser publicados. CONCLUSÃO: Mesmo que tenham sido logrados avanços significativos em nossa compreensão sobre os transtornos do controle dos impulsos, mais pesquisas são necessárias para ampliar o conhecimento existente e traduzir esses achados em avanços clínicos.OBJECTIVE: To review the neurobiological substrates of impulse control disorders. Pathological gambling is a main focus of the review in that most biological studies of the formal impulse control disorders have examined this disorder. METHOD: The medical database Medline from 1966 to present was searched to identify relevant articles that were subsequently reviewed to generate this manuscript

  2. [Grading of neuroendocrine tumors].

    Science.gov (United States)

    Saeger, W; Schnabel, P A; Komminoth, P

    2016-07-01

    The current WHO classification of neuroendocrine tumors (NET) differentiates between typical carcinoids (low grade NET), atypical carcinoids (intermediate grade NET) and small cell and large cell carcinomas (high grade NET) according to the prognosis. Neuroendocrine neoplasms (NEN) of the gastrointestinal tract and the pancreas are graded in an identical way. Together with the TNM system this enables a preoperative estimation of the prognosis in biopsies and fine needle aspirates. Well-differentiated tumors are graded into G1 tumors by the number of mitoses, tumors (2-20 mitoses/10 HPF, Ki-67 3-20 %). Discrepancies between the number of mitoses and the Ki-67 index are not uncommon and in these cases the higher value of the two should be applied. The more differentiated tumors of the G3 type have to be differentiated from undifferentiated carcinomas of the small cell type and large cell type with a much poorer prognosis. Prognosis relevant grading of thyroid cancers is achieved by special subtyping so that the G1-G3 system is not applicable. The rare cancers of the parathyroid gland and of the pituitary gland are not graded. Adrenal tumors also have no grading system. The prognosis is dependent on the Ki-67 index and with some reservations on the established scoring systems. PMID:27379621

  3. Towards tumor immunodiagnostics.

    Science.gov (United States)

    Kourea, Helen; Kotoula, Vassiliki

    2016-07-01

    Immunodiagnostic markers applicable on tissue or cytologic material may be prognostic or predictive of response to immunomodulatory drugs and may also be classified according to whether they are cell-specific or tumor-tissue-specific. Cell-specific markers are evaluated under the microscope as (I) morphological, corresponding to the assessment of tumor infiltrating immune cells on routine hematoxylin & eosin (H&E) sections; and (II) immunophenotypic, including the immunohistochemical (IHC) assessment of markers characteristic for tumor infiltrating immune cells. Tumor-tissue-specific markers are assessed in tissue extracts that may be enriched in neoplastic cells but almost inevitably also contain stromal and immune cells infiltrating the tumor. Such markers include (I) immune-response-related gene expression profiles, and (II) tumor genotype characteristics, as recently assessed with large-scale genotyping methods, usually next generation sequencing (NGS) applications. Herein, we discuss the biological nature of immunodiagnostic markers, their potential clinical relevance and the shortcomings that have, as yet, prevented their clinical application. PMID:27563650

  4. Towards tumor immunodiagnostics

    Science.gov (United States)

    Kotoula, Vassiliki

    2016-01-01

    Immunodiagnostic markers applicable on tissue or cytologic material may be prognostic or predictive of response to immunomodulatory drugs and may also be classified according to whether they are cell-specific or tumor-tissue-specific. Cell-specific markers are evaluated under the microscope as (I) morphological, corresponding to the assessment of tumor infiltrating immune cells on routine hematoxylin & eosin (H&E) sections; and (II) immunophenotypic, including the immunohistochemical (IHC) assessment of markers characteristic for tumor infiltrating immune cells. Tumor-tissue-specific markers are assessed in tissue extracts that may be enriched in neoplastic cells but almost inevitably also contain stromal and immune cells infiltrating the tumor. Such markers include (I) immune-response-related gene expression profiles, and (II) tumor genotype characteristics, as recently assessed with large-scale genotyping methods, usually next generation sequencing (NGS) applications. Herein, we discuss the biological nature of immunodiagnostic markers, their potential clinical relevance and the shortcomings that have, as yet, prevented their clinical application. PMID:27563650

  5. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

    Directory of Open Access Journals (Sweden)

    Jean Nunes SANTOS

    2001-12-01

    Full Text Available One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999. The most common histological diagnosis was odontoma (50.40%, followed by ameloblastoma (30.70%. The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades of life. The main anatomical location was the mandible, and no malignant tumors were found.De uma série de 5.289 casos de lesões orais e dos maxilares diagnosticadas no Laboratório de Patologia Oral da Faculdade de Odontologia da Universidade Federal do Rio Grande do Norte no período de 30 anos (1970-1999, foram analisados 127 casos de tumores odontogênicos confirmados histologicamente. A lesão mais freqüente foi o odontoma (50,40% seguida pelo ameloblastoma (30,70%. A prevalência de tumores odontogênicos foi maior nas mulheres e o pico de incidência ocorreu na segunda e terceira décadas de vida. A localização anatômica mais comum foi a mandíbula e não foram encontrados casos de tumores malignos.

  6. O pensamento inaugural dos direitos humanos pelas lições dos sofistas

    Directory of Open Access Journals (Sweden)

    Hilda Helena Soares Bentes

    2009-12-01

    Full Text Available Propõe-se a analisar as primeiras manifestações de um pensamento  igualitário, base   dos direitos do homem na filosofia jurídica moderna, através do debate travado entre as concepções de phýsis e nómos, iniciado pelos pré-socráticos e desenvolvido intensamente pelos sofistas.

  7. Universidade e comunidade na perspectiva dos movimentos estudantis dos anos 1960

    Directory of Open Access Journals (Sweden)

    Luís Antonio Groppo

    2011-03-01

    Full Text Available Resumo Neste artigo, procuro discutir a práxis dos movimentos estudantis universitários dos anos 1960em relação às "comunidades" no entorno das unidades de ensino. Constata-se, primeiro, uma relativa carência de ações efetivas, principalmente porque os movimentos estudantis se preocupavam, sobretudo, com a intervenção na política nacional e nos rumos gerais da sociedade de que faziam parte. Ainda assim, na sua riqueza e complexidade, os movimentos estudantis dos anos 1960 enfrentaram a questão da relação com a "comunidade", o que se observa em projetos e propostas criativas de ação prática, revelando uma potencialidade que poderia ter sido mais bem aproveitada. Palavras-chave: movimentos estudantis; universidade; comunidade.   Abstract In this article I intend to discuss the praxis from student movements of sixties, in its relations with the "communities" in the universities ‘neighborhoods. I evidence, first, a relative failure of effective actions, principally because the student movements preoccupy, especially, with the intervention in national politic and in the general ways of their societies. Indeed, in their wealth and complexity, the student movements from the sixties confront the question of the relation with the community, what it looks in creative projects and propositions of practical action, what reveals a potentiality what can be better used. Keywords: student movements; university; community.

  8. A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor

    OpenAIRE

    Omer Alici; Musa Kemal Keles; Alper Kurt

    2015-01-01

    Proliferating trichilemmal tumors (PTTs) are neoplasms derived from the outer root sheath of the hair follicle. These tumors, which commonly affect the scalp of elderly women, rarely demonstrate malignant transformation. Although invasion of the tumors into neighboring tissues and being accompanied with anaplasia and necrosis are accepted as findings of malignancy, histological features may not always be sufficient to identify these tumors. The clinical behavior of the tumor may be incompatib...

  9. A exploração sustentada dos recursos naturais no Arquipélago dos Bijagós

    OpenAIRE

    João MADEIRA

    2011-01-01

    Considera-se pertinente este estudo sobre a exploração sustentada dos recursos naturais no Arquipélago dos Bijagós, dada a sua localização estratégica na geografia atlântica e a sua vulnerabilidade às influências externas que afectam o seu equilíbrio secular. Desde 1975 a sociedade guineense tem sido responsável pela utilização descontrolada dos recursos naturais, sobretudo na zona costeira. O Arquipélago tem suscitado numerosos interesses, muitos dos quais incompatíveis com a garantia de um ...

  10. Dois estudos sobre o trabalho dos petroleiros

    Directory of Open Access Journals (Sweden)

    Leda Leal Ferreira

    1996-06-01

    Full Text Available O presente artigo traz um resumo de dois estudos realizados na área do petróleo, o primeiro feito em uma unidade de refino e o segundo abarcando o trabalho de operadores exercendo várias funções dentro de uma refinaria e de terminais marítimos de petróleo. Nos dois casos, o ponto central foi a análise da atividade dos trabalhadores, isto é, o que eles faziam e como o faziam para dai conta das exigências de produção que lhes eram atribuídas. No entanto, os métodos utilizados foram diferentes: no primeiro caso utilizou-se a Análise Ergonômica do Trabalho (AET e no segundo, a Análise Coletiva do Trabalho (ACT. Além de apresentar os principais resultados destes estudos, a autora faz considerações sobre as diferenças entre os dois métodos e um apelo à comunidade científica para que se preocupe mais em estudar a atividade real dos trabalhadores e assim contribuir para um melhor conhecimento do que se passa no interior das unidades produtivas, evitando que sofrimentos humanos inúteis e até catástrofes industriais continuem a ocorrer.This paper describes two studies about petroleum industry. The first was developed in a refinery and the second focuses on the work of operators in various jobs within a refinery and maritime petroleum units. In both cases, the focal point was the analyses of activities, that is, what the workers do and how they do it in order to meet production demandai put on them. However, two different methods were applied in the studies. Ergonomics Work Analyses (EWA was used on the first case and Collective Work Analyses (CWA, on the second. Besides showing the main results, the author compares the two methods. She also draws the scientific community attention to the importance of studding the workers actual activity in order to contribute to a better understanding of what is going on inside production units, avoiding useless human suffering, and the still ocurring undustrial disasters.

  11. [Enophthalmos in an orbital tumor].

    Science.gov (United States)

    Szabo, Bianca; Szabo, I; Nicula, Cristina; Popescu, Livia Adriana

    2013-01-01

    Enophtalmus is an unusual sign of the orbital tumors often represented by proptosis. One patient with enophtalmus and intraorbital tumor and aplasy is presented. The treatment of choice of orbital tumor is complete surgical excision and careful follow-up. Considering the more aggressive course followed by recurrent tumor, correct diagnosis and management is essential.

  12. Brain tumors in infants

    Directory of Open Access Journals (Sweden)

    Seyyed Mohammad Ghodsi

    2015-01-01

    Full Text Available Background: Brain tumors in infants have different clinical presentations, anatomical distribution, histopathological diagnosis, and clinical prognosis compared with older children. Materials and Methods: A retrospective analysis was done in patients <12 months old who were operated on for primary brain tumor in Children's Hospital Medical Center since 2008 to 2014. Results: Thirty-one infants, 20 males and 11 females, with the mean age of 7.13 months (0.5–12 were enrolled. There were 16 supratentorial and 15 infratentorial tumors. The presenting symptoms included increased head circumference (16; bulge fontanel (15; vomiting (15; developmental regression (11; sunset eye (7; seizure (4; loss of consciousness (4; irritability (3; nystagmus (2; visual loss (2; hemiparesis (2; torticollis (2; VI palsy (3; VII, IX, X nerve palsy (each 2; and ptosis (1. Gross total and subtotal resection were performed in 19 and 11 cases, respectively. Fourteen patients needed external ventricular drainage in the perioperative period, from whom four infants required a ventriculoperitoneal shunt. One patient underwent ventriculoperitoneal shunting without tumor resection. The most common histological diagnoses were primitive neuroectodermal tumor (7, followed by anaplastic ependymoma (6 and grade II ependymoma. The rate of 30-day mortality was 19.3%. Eighteen patients are now well-controlled with or without adjuvant therapy (overall survival; 58%, from whom 13 cases are tumor free (disease free survival; 41.9%, 3 cases have residual masses with fixed or decreased size (progression-free survival; 9.6%, and 2 cases are still on chemotherapy. Conclusion: Brain tumors in infants should be treated with surgical resection, followed by chemotherapy when necessary.

  13. Metastatic Brain Tumors

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    Ersin Haciyakupoglu

    2014-04-01

    Full Text Available Metastatic tumor is secondary spread to the central nervous system of primer systemic cancers originating from tissues other than the central nervous system. In adults; there are metastases respectively from lungs, breasts, malign melanoma, renal cell carcinoma, colon and thyroid cancers. 30-60% of lung cancers metastasis to the brain. In children there are quite a few cerebral metastases. Most commonly leukemia, lymphoma, osteogenic sarcoma, rhabdomyosarcoma and germ cell tumors metastasis to the brain. %50 of malign melanoma, lung, breast and colon cancers intend to make multipl metastases but renal cell cancers intend to make solitary metastasis.While lung cancers metastasis to brain in 6-9 months after the definitive diagnosis, renal cancers in 1 year, colon cancers in 2 years, breast cancers and malign melanoma in 3 years metastasis to brain. In 6% of cases there are cerebral metastasis while there isn’t a symptom of a primary tumor. For treatment corticosteroids, surgery, Radiotherapy(RT, Chemotherapy(CT and Stereotactic Radiosurgery(SRS can be implemented. Small cell lung cancers, lymphoma, germ cell tumors are sensitive to RT and CT. Non small cell lung cancers, renal, colon cancers and malign melanoma are radioresistant. The purposes in the surgery of the metastatic brain tumors are; total resection of tumors without neurologic deficits, decreasing the intracranial pressure and decreasing the dose of postoperative radiotherapy. Key Words: Metastatic brain tumors, Stereotactic radiosurgery, Malign melanoma, Lung cancers, Renal cell carcinoma, Radiotherapy, Chemotherapy [Cukurova Med J 2014; 39(2.000: 191-202

  14. Identificação dos insulinomas pela ecoendoscopia Identification of insulinomas by endoscopic ultrasonography

    Directory of Open Access Journals (Sweden)

    José Celso Ardengh

    2004-04-01

    Full Text Available OBJETIVO: Demonstrar a sensibilidade da ecoendoscopia (EE no diagnóstico pré-operatório dos insulinomas e comparar com outros testes diagnósticos como tomografia helicoidal e ressonância magnética. MÉTODOS: Trinta pacientes foram examinados prospectivamente pela ecoendoscopia com o diagnóstico clínico de insulinoma antes de serem submetidos ao tratamento cirúrgico. O exame ecoendoscópico sempre foi precedido pelo US, TC helicoidal e em 10 pacientes pela RM. Em 12 casos foi indicada a punção aspirativa com agulha fina eco-guiada para confirmar a suspeita de insulinoma. RESULTADOS: A sensibilidade da EE na identificação dessas lesões foi de 86,6% (26/30 tumores. Vinte e seis tumores foram benignos (86,6% e quatro malignos (13,4%. Realizamos punção biópsia aspirativa em 12 pacientes (40% e o diagnóstico histológico foi feito em 10/12 pacientes (83,3%. Nessa casuística, 25 tumores foram menores que 2 cm (83,3% e cinco maiores que 2 cm (16,7%. Os tumores detectados pela EE tinham tamanho médio de 1,5 cm (0,6 a 5,4 cm. A identificação dos tumores pela EE na cabeça, corpo e cauda foi de 100%, 100% e 55,5%, respectivamente. CONCLUSÃO: A EE tem alta sensibilidade na identificação e localização dessas lesões e deve ser recomendada quando os métodos tradicionais de imagem empregados falham no diagnóstico. A PAAF é uma tentativa para evitarmos falso-positivos.BACKGROUND: The aim of this study is to compare EUS and the others diagnostics tests in the correct localization of insulinomas. METHODS: We prospectively investigated 30 patients with endoscopic ultrasound with a clinical diagnosis of insulinomas prior to surgical exploration. They were submitted to abdominal ultrasonography, spiral computed tomography and four patients were submitted to magnetic ressonance before EUS. Surgery was the gold standard for tumor localization. RESULTS: Twenty-six tumors were benign (86.6% and four were malign (13.4%. The median size

  15. Dos celebraciones religiosas en un mundo globalizado

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    María Iracheta

    2009-01-01

    Full Text Available Este artículo intenta responder a la pregunta ¿cómo permanecen dos fiestas religiosas mexicanas -la de la Nuestra Señora de Tonatico, en su Santuario, ubicado en el municipio de Tonatico, Estado de México y la de la Virgen del Rosario en su iglesia del Barrio de Xochimilco, -en la ciudad de Oaxaca, capital del Estado de Oaxaca, -en el contexto de la modernización y la globalización? Tres elementos ayudan a explicar esta permanencia: la tradición, que es asumida y reproducida por el "linaje de creyentes" pasados, presentes y futuros; el ritual, que reproduce la memoria histórica y la identidad local; y la apropiación de elementos culturales ajenos a la cultura local para sobrevivir en contextos globales. Estas celebraciones permiten restituir la armonía en los pueblos o barrios, que han cambiado drásticamente por la inserción de los mismos en un mercado mundial. También generan la percepción de tener el control de la comunidad frente a los grandes procesos externos que la amenazan: la mancha urbana, el comercio internacional, los medios masivos de comunicación, la cultura de masas, entre otros.

  16. Grupos de nudos con dos generadores

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    Christian Pommerenke

    2011-06-01

    Full Text Available Se estudian grupos de nudos que admiten una presentación con dos generadores y una relación. Decimos que una presentación �a, b | r� es palindrómica si r es una palabra palíndromo, es decir, r es una palabra que se lee lo mismo de adelante para atrás que de atrás para adelante. Estudiamos condiciones bajo las cuales es posible cambiar la presentación dada para obtener una presentación palindrómica. Probamos que si el grupo G de un nudo admite una representación fiel en un subgrupo discreto de SL(2, C, entonces G admite una presentación palindrómica. Abstract. We study knot groups that admit a presentation with two generators and one relation. We say that a presentation �a, b | r� is palindromic if r is a palindrome, that is, if r is a word that reads the same forwards and backwards. We study conditions that allow us to change the given presentation to obtain a palindromic presentation. We prove that if the knot group G admits a faithful discrete SL(2, C-representation then G admits a palindromic presentation.

  17. LAS DOS TRÍADAS DEBEJARANO

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    Jorge Iván González

    Full Text Available El artículo diseute "dos tríadas" que propone Bejarano para calificar a la teoría económica actual. La primera tríada tiene que ver con el realismo, la pertinencia y la relevancia de la teoría. Y la segunda tríada con sus dimensiones política, institucional y moral. El artículo centra la atención en esta segunda tríada, argumentando que la teoría no es apolítica, ainstitucional y amoral como afirma Bejarano. El examen crítico de la posición de Bejarano se sustenta en algunas de las tesis de: Walras, Marshall, Hicks, vickrey, Samuelson y Arrow.This article discusses the "two triads" that Bejarano has proposed in order to describe present economic theory. The first triad refers to the realism, pertinence and relevance of the theory. The second triad to its political, institutional and moral dimension. The article centers its attention on this second triad, arguing that the theory is not apolitical, uninstitutional and amoral as Bejarano states. The critical examination of Bejarano's proposition is supported on thesis of Walras, Marshall, Hicks, Vickrey, Samuelson and Arrow.

  18. Angiografia por tomografia computadorizada dos aneurismas intracranianos

    Directory of Open Access Journals (Sweden)

    Laureano Vinícius Santos

    2002-01-01

    Full Text Available Este trabalho foi realizado para avaliar os achados da angiografia por tomografia computadorizada, comparativamente à angiografia por subtração digital, em relação aos aneurismas intracranianos, e a possibilidade da maior utilização da angiografia por tomografia computadorizada no Brasil. Foram analisados oito pacientes que apresentavam um total de sete aneurismas não tratados e um aneurisma tratado. Houve subseqüente correlação com outros trabalhos publicados na literatura médica. Os exames foram realizados em uma clínica e em dois hospitais privados, na cidade do Rio de Janeiro, RJ. Foi demonstrada boa correlação entre os métodos estudados, em relação ao diagnóstico dos aneurismas, no acompanhamento e avaliação pré-terapêutica dessas lesões. A angiografia por tomografia computadorizada foi um exame menos invasivo, de menor custo e maior acessibilidade. Concluiu-se que a angiografia por tomografia computadorizada é um exame que deve ser utilizado com maior freqüência para avaliação nesta enfermidade.

  19. Pituitary gland tumors; Hypophysentumoren

    Energy Technology Data Exchange (ETDEWEB)

    Jesser, J.; Schlamp, K.; Bendszus, M. [Radiologische Klinik, Universitaetsklinikum Heidelberg, Abteilung fuer Neuroradiologie, Heidelberg (Germany)

    2014-10-15

    This article gives an overview of the most common tumors of the pituitary gland and the differential diagnostics with special emphasis on radiological diagnostic criteria. A selective search of the literature in PubMed was carried out. Pituitary adenomas constitute 10-15 % of all intracranial tumors and are the most common tumors of the sellar region. Tumors smaller than 1 cm in diameter are called microadenomas while those larger than 1 cm in diameter are called macroadenomas. Approximately 65 % of pituitary gland adenomas secrete hormones whereby approximately 50 % secrete prolactin, 10 % secrete growth hormone (somatotropin) and 6 % secrete corticotropin. Other tumors located in the sella turcica can also cause endocrinological symptoms, such as an oversecretion of pituitary hormone or pituitary insufficiency by impinging on the pituitary gland or its stalk. When tumors spread into the space cranial to the sella turcica, they can impinge on the optic chiasm and cause visual disorders. A common differential diagnosis of a sellar tumor is a craniopharyngeoma. In children up to 10 % of all intracranial tumors are craniopharyngeomas. Other differential diagnoses for sellar tumors are metastases, meningiomas, epidermoids and in rare cases astrocytomas, germinomas or Rathke cleft cysts As these tumors are located in an anatomically complex region of the skull base and are often very small, a highly focused imaging protocol is required. The currently favored modality is magnetic resonance imaging (MRI) with the administration of a contrast agent. The sellar region should be mapped in thin slices. In cases of suspected microadenoma the imaging protocol should also contain a sequence with dynamic contrast administration in order to assess the specific enhancement characteristics of the tumor and the pituitary gland. (orig.) [German] Diese Arbeit ist eine Uebersicht ueber die haeufigsten Hypophysentumoren und deren Differenzialdiagnosen mit Augenmerk auf die

  20. Thermoradiotherapy of malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Hatano, Kazuo; Itami, Jun; Arimizu, Noboru (Chiba Univ. (Japan). School of Medicine); Uno, Takashi; Toita, Takafumi; Shiina, Takeki; Mikuriya, Shuuichi; Yamada, Tsunehisa

    1991-06-01

    From October 1986 to June 1989, 79 patients with malignant tumors were treated by radiation therapy combined with hyperthermia at National Medical Center Hospital. Seventy two patients (male: 48, female: 23) were evaluable. Average age was 62.4 years old (ranged 20-81 years old). Irradiation was delivered twice to fifth weekly in tumor doses of 50 to 60 Gy (TDF 82-122). We used 3 types of hyperthermic equipment, Thermotron RF8, BSD 1000 System and Endoradiotherm 100A. Hyperthermia was initiated within 30 minutes following irradiation, most of the patients being treated with adequate equipment, 41-44degC, for 60-70 minutes every 72 hours. Fifteen of 71 patients (20.8%) showed a complete response and 36 patients (50%) showed a partial response, so effective rate was 70.8% of all. In superficial tumors, 4 of 21 patients (21.5%) showed a complete response and 8 of 21 patients showed a partial response, effective rate was 63.2% of all. In deep seated tumor, 10 of 46 patients (21.7%) showed a complete response and 25 of all patients showed a partial response, so effective rate was 76.1% of all. Five patients were heated following only intra-tumor injection of OK-432 and its effective rate was 75%. We think that this modality of therapy will be effective in cases which heating area had been irradiated over tolerable doses. CR rate of superficial tumors according to intra-tumor center temperature tends to higher in the cases of higher tumor temperature. In deep seated tumor, 11 patients (23.9%) had reached over 43degC, 29 patients (63.0%) heated 41-43degC, 6 patients (13.0%) heated under 41degC and CR rate of each group were 36.4%, 17.2%, 16.7%, respectively. We think that thermotherapy with irradiation is an effective therapy in the treatment of malignancies but the improvement of heating equipment will be expected. (author).

  1. Extraovarian granulosa cell tumor

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    Paul Prabir

    2009-04-01

    Full Text Available Extraovarian granulosa cell tumor (GCT is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. One such rare case of extraovarian GCT was encountered in a 58-year-old female who presented with a large intraabdominal lump. Computerized tomography revealed one large retroperitoneal mass measuring 15cm x 16cm and another mesenteric mass of 8cm x 5cm size. The patient had a history of hysterectomy with bilateral salpingooophorectomy 20 years ago for uterine leiomyoma. Ultrasonography-guided aspiration smears revealed cytological features suggestive of GCT. Histopathological examination of the excised masses showed features of adult-type GCT. Because metastatic epithelial tumors, particularly from the ovaries, may show identical morphology, immunostains for inhibin and epithelial membrane antigen (EMA were performed. The tumor showed positivity for inhibin while EMA was negative thus confirming the diagnosis of GCT. As this patient had no previous history of GCT and was oophorectomized 20 years ago, the tumor was considered as extraovarian. A diagnosis of extraovarian GCT should be carried out after excluding any previous history of GCT of the ovary. Immunostains help to differentiate GCTs from other neoplasms.

  2. Cryoablation for pulmonary tumor

    International Nuclear Information System (INIS)

    We have experienced more than 200 sessions for mainly metastatic lung tumor and small number of primary lung cancer since 2002. Cryo-probe is inserted percutaneously with local anesthesia under CT scan guide. Co-axial technique is adopted to prevent from hemorrhage and massive air leakage. The average of hospital stay after treatment is 2.6 days. Although pneumothorax was associated with more than half patients, 5% of them experienced chest tube insertion. Local recurrence 1 year after treatment was found 10% of tumors of 10 mm or less diameter, 30% of 11-20 mm diameter, and 40% of 20-30 mm diameter and 100% of 31 mm or more diameter. In case of large vessels (3 mm or more diameter) running within 4 mm from tumor, recurrence rate was higher compared with the same sized tumors without large vessels running nearby. We are eager for the development of 3D-simulation system considering the distribution of caloric value is strongly requested to improve the local control power of cryoablation for lung tumor. (author)

  3. Endolymphatic sac tumor : a rare cerebellopontine angle tumor.

    Directory of Open Access Journals (Sweden)

    Joseph B

    2002-10-01

    Full Text Available Endolymphatic sac tumors (ELST are rare papillary tumors of the temporal bone. Previously named as aggressive papillary middle ear tumors, they have recently been shown to arise from the endolymphatic sac. They are a rare in cerebello-pontine angle (CPA. We present a case of an ELST who presented as a CPA tumor with hydrocephalus. He underwent a ventriculo-peritoneal shunt initially. On exploration of the CP angle, the tumor was found to be extremely vascular. He was re-explored following embolization, and a subtotal excision of the tumor was done. Extensive petrous bone infiltration and vascularity of the tumor makes total excision almost impossible with high risk of cranial nerve deficits, excessive blood loss and CSF leak. This tumor should be considered in the differential diagnosis of vascular CPA tumors which erode the petrous temporal bone. The relevant literature is reviewed.

  4. [Familial pituitary tumors].

    Science.gov (United States)

    Yoshimoto, K; Saito, S

    1995-11-01

    Familial pituitary tumors are relatively rare. Most commonly, they occur as a part of multiple endocrine neoplasia type 1 (MEN 1). However, familial pituitary adenomas unrelated MEN 1 (familial pituitary adenomas) are extremely rare. In review of MEN 1 in Japan, 60% of the patients with MEN 1 had pituitary tumors. Only 45 cases of familial pituitary adenomas have been reported from 20 families. In our review of familial pituitary adenomas, 30 (67%) of 45 reported cases are acromegaly or gigantism. This incidence is much higher than 28% in MEN 1 patients with pituitary tumors. Allelic deletions at 11q13 were identified in MEN 1 associated pituitary adenomas and familial pituitary adenomas in two gigantism brothers. PMID:8538028

  5. Renal Tumor Biopsy Technique

    Institute of Scientific and Technical Information of China (English)

    Lei Zhang; Xue-Song Li; Li-Qun Zhou

    2016-01-01

    Objective:To review hot issues and future direction of renal tumor biopsy (RTB) technique.Data Sources:The literature concerning or including RTB technique in English was collected from PubMed published from 1990 to 2015.Study Selection:We included all the relevant articles on RTB technique in English,with no limitation of study design.Results:Computed tomography and ultrasound were usually used for guiding RTB with respective advantages.Core biopsy is more preferred over fine needle aspiration because of superior accuracy.A minimum of two good-quality cores for a single renal tumor is generally accepted.The use of coaxial guide is recommended.For biopsy location,sampling different regions including central and peripheral biopsies are recommended.Conclusion:In spite of some limitations,RTB technique is relatively mature to help optimize the treatment of renal tumors.

  6. [Hepatic tumors and radiotherapy].

    Science.gov (United States)

    Rio, E; Mornex, F; Peiffert, D; Huertas, A

    2016-09-01

    Recent technological developments led to develop the concept of focused liver radiation therapy. We must distinguish primary and secondary tumors as the indications are restricted and must be discussed as an alternative to surgical or medical treatments. For hepatocellular carcinoma 5 to 10cm (or more), a conformational radiation with or without intensity modulation is performed. Stereotactic body radiotherapy (SBRT) is being evaluated and is increasingly proposed as an alternative to radiofrequency ablative treatment for primary or secondary tumors (typically less than 5cm). Tumor (and liver) movements induced by respiratory motions must be taken into account. Strict dosimetric criteria must be met with particular attention to the dose-volume histograms to liver and the hollow organs, including cases of SBRT. PMID:27521035

  7. Upper urinary tract tumors

    DEFF Research Database (Denmark)

    Gandrup, Karen L; Nordling, Jørgen; Balslev, Ingegerd;

    2014-01-01

    BACKGROUND: Computed tomography urography (CTU) is used widely in the work-up of patients with symptoms of urinary tract lesions. Preoperative knowledge of whether a tumor is invasive or non-invasive is important for the choice of surgery. So far there are no studies about the distinction...... of invasive and non-invasive tumors in ureter and renal pelvis based on the enhancement measured with Hounsfield Units. PURPOSE: To examine the value of CTU using split-bolus technique to distinguish non-invasive from invasive urothelial carcinomas in the upper urinary tract. MATERIAL AND METHODS: Patients...... obtained at CTU could distinguish between invasive and non-invasive lesions. No patients had a CTU within the last year before the examination that resulted in surgery. CONCLUSION: A split-bolus CTU cannot distinguish between invasive and non-invasive urothelial tumors in the upper urinary tract...

  8. A Importância dos Carboidratos na Alimentação dos Eqüinos

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    Eliane Morgado:

    2008-10-01

    Full Text Available Os carboidratos são extremamente importantes na dieta dos eqüinos,sendo os carboidratos não estruturais as fontes primárias de energia. Os monossacarídeos são as únicas formas de carboidratos que podem ser absorvidos pelo intestino delgado e os carboidratos mais complexos são fermentados no intestino grosso, onde ocorre a fermentação microbiana. As frações dos carboidratos são definidas pelos métodos químicos ou enzimáticos utilizados nas análises, e vários são os métodos de avaliação da qualidade das forragens, e da composição bromatológica dos ingredientes. O sistema de partição dos carboidratos mais adequada à fisiologia digestiva dos eqüinos, seria o fracionamento dos carboidratos não fibrosos em grupo dos Carboidratos hidrolisáveis a açúcar simples no intestino delgado, e grupo dos carboidratos fermentáveis no intestino grosso, produzindo ácidos graxos voláteis.

  9. Adult brain tumors

    International Nuclear Information System (INIS)

    Radiotherapy plays an important role in the management of adults with brain tumors. This refresher course will focus on a variety of benign and malignant brain neoplasms and how contemporary radiotherapy affects outcome. Successful outcome after radiotherapy requires that (1) there is no tumor extension beyond the selected target volume, (2) adequate dose is delivered to the target volume, and (3) normal tissue tolerance dose is not exceeded. For many neoplasms serial post-treatment scans may show little change, and success is often measured more by absence of tumor progression than by scan normalization. Three-dimensional treatment planning based on MRI or CT makes it possible to guarantee delivery of the full prescription dose to gross tumor while minimizing the volume of normal tissue receiving high dose. Acceptable dose conformity can often be achieved with 2-4 static beams or arcs, which is usually preferable to opposed lateral fields. Protocols involving substantial dose escalation require a large number of non-coplanar x-ray beams or particle therapy. This course will cover important concepts and techniques which relate to the treatment of brain tumors, including conformal radiotherapy, brachytherapy, radiosurgery, fractionated stereotactic radiotherapy, altered fractionation, inverse treatment planning, re-irradiation, and biologically effective dose (BED). Examples of planning solutions for a variety of tumor types, size and anatomical locations will be given. Note: I will incorporate examples of interesting, difficult and unusual cases from other practices as time permits, provided slides and descriptive materials are sent to me in advance of the course

  10. OS VIDEOJOGOS: AS REPRESENTAÇÕES DOS PAIS SOBRE A PRÁTICA DOS FILHOS

    Directory of Open Access Journals (Sweden)

    Sílvia Coimbra

    2015-04-01

    Full Text Available Os videojogos são um fenómeno com crescimento progressivo desde a década de 70, alojando-se na vida das crianças, dos jovens e até mesmo na dos adultos. Ao passarem muitas horas em frente a um ecrã as crianças podem estar a tornar-se pequenas pessoas inativas, porque as horas que passam a jogar videojogos poderiam ser dedicadas à actividade física, tornando assim as crianças mais ativas e menos sedentárias (Bergamasco et al., 2008. O magnetismo exercido pelos videojogos pode assustar os intervenientes da educação, pois as crianças e jovens de hoje passam horas a jogar, e nesse período de tempo não se consegue saber o que é que as crianças aprendem, ou não aprendem (Pereira, 2007. As investigações nesta área têm abordado esta temática, demonstrando que é importante ter atenção aos conteúdos e número de horas que as crianças dispensam a jogar de forma a poder haver um maior controle desse tempo (Marivoet, 2001; Moita, 2007; Pereira, 2007.Objetivo: Contribuir para o conhecimento e aprofundamento da problemática dos videojogos, relativamente à representação que os pais têm sobre a sua influência no desenvolvimento das crianças, as horas que os seus filhos passam a jogar e ainda se o tempo de jogo furta tempo à actividade física.

  11. Dos iglesias de Pierre Pinsard, arquitecto Francia

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    Pinsard, Pierre

    1972-09-01

    Full Text Available Parish Centre of Saint Pierre de Chanel, Bourg-en-Bresse It is located in the modern part of the town, and is built on three levels: — Basement, with public garage. — Ground floor, which has nave with seating capacity for 639, chapel, mortuary, sacristy, presbytery and offices, as well as courtyard, garden, car-park and belfry. — Upper floor, with catechism rooms, gallery, offices and sitting rooms annexed to the presbytery. The basic construction is of expossd concrete with metal columns. Parish Centre of Saint Jean Baptiste de La Salle, Rouen This building is situated on the left bank of the Seine. Consisting of one floor only, it has a main nave with room for 600, a chapel, catechism rooms, two sacristies, mortuary, presbytery, choir and gardens. The construction is of concrete faced with brick, and metal roof with interior wood lining.Centro Parroquial de San Pedro de Chanel, en Bourg-en-Bresse Esta situado en la zona moderna y se ha distribuido en tres plantas: — Sótano: con garaje público. — Planta noble: con nave capaz para 639 plazas, capilla, mortuorio, sacristía, presbiterio y oficinas; además de la plaza, el jardin, aparcamiento y campanil. — Planta alta: con salas de catecismo, tribuna, oficinas y estancias anejas al presbiterio. Construcción fundamental de hormigón visto con pilares metálicos. Centro Parroquial de San Juan Bautista de La Salle, en Ruán Está situado en la orilla izquierda del Sena. Consta de una sola planta, con nave para 600 fieles, capilla, salas de catecismo, dos sacristías, mortuorio, presbiterio, coro y jardines. Construcción a base de hormigón, fábrica de ladrillo a cara vista y cubierta metálica revestida de madera el interior.

  12. ESTUDO SOBRE O IMPACTO DOS PROCESSADORES HOSPEDEIROS

    Directory of Open Access Journals (Sweden)

    Alba S. B. Lopes

    2008-05-01

    Full Text Available Arquiteturas reconfiguráveis são dispositivos de hardware capazes de modificar sua estrutura de hardware de acordo com a aplicação a ser executada. Tais dispositivos surgiram como uma alternativa às soluções de hardware tradicionais na tentativa de equilibrar flexibilidade e desempenho. Uma das principais formas de utilização de arquiteturas reconfiguráveis corresponde a um bloco reconfigurável anexado a um processador hospedeiro. Esse processador é responsável por executar diversas tarefas críticas, incluindo o particionamento hardware/software e indicar o momento do bloco reconfigurável executar. Apesar de existirem diversas propostas de arquiteturas reconfiguráveis na literatura, pouco se estudou sobre o impacto do processador hospedeiro na arquitetura. Nesse contexto, esse artigo apresenta um estudo sobre o impacto do processador hospedeiro no desempenho da arquitetura reconfigurável híbrida. Como estudo de caso foi realizada uma avaliação sobre o uso dos processadores SPARC V8 da Sun Microsystems e Nios II da Altera como processadores hospedeiros da arquitetura reconfigurável híbrida RoSA. O objetivo deste estudo é realizar a comparação entre o desempenho desses processadores e identificar qual deles é o mais adequado para anexar a arquitetura em questão. Os resultados mostraram que foi possível alcançar até 47% de ganho de desempenho com o uso do processador Nios II em comparação ao SPARC V8, indicando o primeiro como mais adequado para a arquitetura RoSA. PALAVRAS-CHAVE: arquiteturas reconfiguráveis, processador hospedeiro, desempenho.

  13. Pediatric sinonasal tumors

    International Nuclear Information System (INIS)

    This paper demonstrates the pathology and imaging characteristics of pediatric sinonasal tumors, which are distinctly different from those found in adults. The medical records, radiologic studies, and pathologic findings in 51 patients, aged 18 years or younger, with sinonasal tumors were retrospectively reviewed. CT images and histopathologic correlation were available in all 51 cases, angiography in 17, and MR in 3. The majority of lesions were benign (33/51), with juvenile angiofibroma being the most common (10/33), followed by fibro-osseous lesions (9/33)

  14. Evaluation of conventional x-ray diagnostic equipment and radiological protection systems of hospitals and clinics installed in Recife city, Brazil; Avaliacao dos equipamentos de raios-X diagnostico convencionais e dos sistemas de protecao radiologica de clinicas e hospitais da cidade de Recife

    Energy Technology Data Exchange (ETDEWEB)

    Passos, Robson Silva

    1999-05-15

    Diagnostic radiology is the main contributor to the man-made exposure of general population. Since Quality Assurance (QA) programs ensure high quality diagnostic images with the lowest possible radiation dose to the patient, it has been recommended that all introduce QA programs for their radiological facilities. Consequently it is important to check the adequacy of equipment operating parameters in diagnostic radiography facilities, to ensure that a high quality of service is delivered. The purpose of this study was to evaluate the operating conditions of diagnostic units installed in Recife, Pernambuco. The study included 31 X-ray units from both public and private diagnostic services. The following parameters were evaluated: coincidence between the luminous and radiation fields; alignment of the radiation beam; agreement between the real and preset values of kVp and exposure time; filtration; half value lower (HVL); luminance of the view box; uniformity of the luminance; illuminance of the environment. The results showed that 20% of the equipment surveyed exhibited discrepancies between the luminous and radiation fields greater than 2% of the source to skin distance. The test of kilovoltage showed that 48% of the units do not fulfill the acceptability criteria, presenting discrepancies higher than {+-} 10% between the measured and preset values. The results of the accuracy of the timer indicated that 81% of the equipment surveyed present a discrepancy greater than {+-} 10% between the time selected in the control panel and actual exposure time.The test of the filtration shown that, in 20% of the equipment, this was inferior to 2,5 mm Al. The test of the luminance of view box shown that 96% of the equipment, shown a luminance lower of 2.000 cd/m{sup 2}. Related to the test of the uniformity of the luminance, 81 % of the equipment shown a variation of the uniformity higher then 10%. The test of the iluminancy of the environment shown that 61 % of the equipment presented on iluminancy level out of the gap between 50 and 100 lux. The results of this survey showed that a high percentage of the equipment surveyed demonstrated inadequate operating conditions, reinforcing the need to implement quality control protocols in conventional x-ray units located in Recife. (author)

  15. Assessment of impact of a severe accident at nuclear power plant of Angra dos Reis with release of radionuclides to the atmosphere; Avaliacao do impacto de um acidente severo na usina de Angra dos Reis com liberacao de radionuclideos para a atmosfera

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, Andre Silva de

    2015-07-01

    This study had as purpose the assess the impact of a severe accident, and also analyze the dispersion of {sup 131}I in the atmosphere, so that, through concentrating and inhaling dose of the plume, were possible to verify if the results are in accordance with the indicated data by the Plan of Emergency of the CNAAA regarding the Impact Zone and Control. This exercise was performed with the aid of an atmospheric model and a dispersion where to atmospheric modeling we used the data coupling WRF / CALMET and of dispersion, CALPUFF. The suggested accident consists of a Station Blackout at Nuclear Power of Angra (Unit 1), where through the total core involvement, will release 100% of the {sup 131}I to the atmosphere. The value of the total activity in the nucleus to this radionuclide is 7.44 x 1017 Bq, that is relative on the sixth day of burning. This activity will be released through the chimney at a rate in Bq/s in the scenario of 12, 24, 48 and 72 hours of release. Applying the model in the proposed scenario, it is verified that the plume has concentrations of the order of 1020 Bq/m³ and dose of about 108 Sv whose value is beyond of the presented by Eletronuclear in your current emergency plan. (author)

  16. Evaluation of the ionizing radiation effects of the {sup 60}Co on the physical, chemical and nutritional properties of Phaseolus vulgaris L. e Vigna unguiculata (L.) Walp beans; Avaliacao dos efeitos da radiacao ionizante de {sup 60}Co em propriedades fisicas, quimicas e nutricionais dos feijoes Phaseolus vulgaris L. e Vigna unguiculata (L.) Walp

    Energy Technology Data Exchange (ETDEWEB)

    Villavicencio, Anna Lucia Casanas Haasis

    1998-07-01

    The effects of {sup 60} Co ionizing radiations in doses of 0; 0.5; 1.5; 2.5; 5.0 and 10 kGy on beans, Phaseolus vulgaris L., of the carioca variety and Vigna unguiculata (L.) Walp, of the macacar variety stored for 6 months were studied. The cooking time was established, and then the following analyses were carried out: Sensory, vitamins B{sub 1}, B{sub 2} and B{sub 6} protein content, biological evaluation in rats (Food intake and Weight gain (in grams)), apparent Digestibility (Dapp), apparent Net Protein Utilization (NPUapp) and apparent Biological Value (BVapp), as well as the applicability of detection methods of irradiated foodstuffs through germination tests, the analysis of DNA migration, thermoluminescence and analysis of the carbohydrates formed by radiation. Changes in the cooking time were observed for all doses. In doses up to 1 kGy, the nutritional quality of the irradiated beans were not altered. The application of the proposed detection methods of the irradiated foodstuffs allowed the detection of irradiated beans with doses as low as 0.5 kGy. (author)

  17. Determination of enrichment processes and the concentrations of radon in underground mines of fluorite and coal in Santa Catarina state: criteria for evaluation of radiological risks; Determinacao dos processos de enriquecimento e das concentracoes de Radonio em minas subterraneas de fluorita e carvao do estado de Santa Catarina: criterios para avaliacao dos riscos radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Carlos Eduardo Lima dos

    2008-07-01

    The inhalation of radon present in underground mines can imply in the deposition of its descendent in the lungs, which may cause harm to the lungs tissues and induce cancer. Concentration of radon not greater than 500 Bq/m3 in the environment of underground mines is considered to be acceptable internationally and concentrations above 1500 Bq/m3 require protective measures for the miners. The objectives of this research work are to determine the enrichment processes and the concentrations of radon in air, as well as the resulting doses due to the presence of this radionuclide in three underground mines of fluorite and three underground mines of coal in the State of Santa Catarina. The concentration of radon was measured employing two types of detectors of nuclear tracks (SSNTD), the LEXAN and the CR-39. This detection method consists in counting, with the help of a microscope, tracks resulting from the interaction of alpha particles with the film, due to the penetration of Rn-222 in the interior of the detector chamber and its decaying process. Contents of radium in collected samples of rocks, minerals and underground water were determined and compared with the corresponding radon concentration found in the underground air. It was observed that the coal mines showed low concentrations of radon, which can be explained by the low concentration of radium in rocks (sandstones and siltites in the footwall and hang wall) and in the coal that composes the mining environment or, yet still, due to the good ventilation system. The average dose to the workers of the coal mines was estimated as 0.7 mSv/a, value inferior to the limit of 1 mSv/a established by the Brazilian Nuclear Energy Commission (CNEN) for members of the public, and corresponding to a risk of fatal cancer after 50 years of work under this condition of 0.2%. On the other hand, the fluorite mines showed much higher concentrations of radon and superior to 1000 Bq/m3. The inefficiency of the ventilation system and the liberation of radon during the various explosions may have contributed to the high concentrations of radon in these mines since the concentration of radium in the rocks (normal and weathered granites) and in the minerals (green and purple fluorides) that compose the mining environment are not high. The modification of the ventilation system of one of the fluorite mines was sufficient to reduce the radon concentration to levels of the order of 500 Bq/m3. The weathered granite contributes more significantly to the increase of the concentration of Rn-222 in the air than the other rocks here studied, i.e. normal granite as well as green and purple fluorite. The miners of the fluorite mines are exposed to effective radiation doses of the order of 12 mSv/a, value inferior to the dose limit of 20 mSv/a established in the Brazilian regulation for occupationally exposed individuals and corresponding to a risk of fatal cancer after 50 years of work under this condition of 2,5%. The need to consider the miners of the fluorite mines as occupationally exposed individuals or the improvement of the ventilation system, based on considerations of the optimization of the radiological protection is discussed and suggestions for future work are presented. (author)

  18. Determination of enrichment processes and radon concentration in underground mines of fluorite and coal in Santa Catarina state: criteria for radiation risk assessment; Determinacao dos processos de enriquecimento e das concentracoes de radonio em minas subterraneas de fluorita e carvao do estado de Santa Catarina: criterios para avaliacao dos riscos radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Carlos Eduardo Lima dos

    2008-07-01

    The inhalation of radon present in underground mines can imply in the deposition of its descendants in the lungs, which may cause harm to the lungs tissues and induce cancer. Concentration of radon not greater than 500 Bq/m{sup 3} in the environment of underground mines is considered to be acceptable internationally and concentrations above 1500 Bq/m{sup 3} require protective measures for the miners. The objectives of this research work are to determine the enrichment processes and the concentrations of radon in air, as well as the resulting doses due to the presence of this radionuclide in three underground mines of fluorite and three underground mines of coal in the State of Santa Catarina. The concentration of radon was measured employing two types of detectors of nuclear tracks (SSNTD), the LEXAN and the CR-39. This detection method consists in counting, with the help of a microscope, tracks resulting from the interaction of alpha particles with the film, due to the penetration of Rn-222 in the interior of the detector chamber and its decaying process. Contents of radium in collected samples of rocks, minerals and underground water were determined and compared with the corresponding radon concentration found in the underground air. It was observed that the coal mines showed low concentrations of radon, which can be explained by the low concentration of radium in rocks (sandstones and siltites in the foot wall and hang wall) and in the coal that composes the mining environment or, yet still, due to the good ventilation system. The average dose to the workers of the coal mines was estimated as 0.7 mSv/a, value inferior to the limit of 1 mSv/a established by the Brazilian Nuclear Energy Commission (CNEN) for members of the public, and corresponding to a risk of fatal cancer after 50 years of work under this condition of 0.2%. On the other hand, the fluorite mines showed much higher concentrations of radon and superior to 1000 Bq/m{sup 3}. The inefficiency of the ventilation system and the liberation of radon during the various explosions may have contributed to the high concentrations of radon in these mines since the concentration of radium in the rocks (normal and weathered granites) and in the minerals (green and purple fluorides) that compose the mining environment are not high. The modification of the ventilation system of one of the fluorite mines was sufficient to reduce the radon concentration to levels of the order of 500 Bq/m{sup 3}. The weathered granite contributes more significantly to the increase of the concentration of Rn-222 in the air than the other rocks here studied, i.e. normal granite as well as green and purple fluorite. The miners of the fluorite mines are exposed to effective radiation doses of the order of 12 mSv/a, value inferior to the dose limit of 20 mSv/a established in the Brazilian regulation for occupationally exposed individuals and corresponding to a risk of fatal cancer after 50 years of work under this condition of 2,5%. The need to consider the miners of the fluorite mines as occupationally exposed individuals or the improvement of the ventilation system, based on considerations of the optimization of the radiological protection is discussed and suggestions for future work are presented. (author)

  19. Calidad percibida por dos poblaciones adscritas a dos centros de salud de la provincia de Cuenca

    Directory of Open Access Journals (Sweden)

    Retamal González Antonio

    2000-01-01

    Full Text Available FUNDAMENTO: Para prestar un servicio de calidad es fundamental conocer la opinión que sobre la misma tienen los usuarios del mismo. El objetivo del presente trabajo es medir y comparar la calidad percibida por dos poblaciones asignadas a dos centros de salud de la provincia de Cuenca. MÉTODO: Se trata de un estudio descriptivo transversal. Las Zonas Básicas de Salud estudiadas han sido el Centro de Salud de Cardenete y Centro de Salud de Motilla del Palancar, ambos del Área de Salud de Cuenca. Se ha hecho un muestreo aleatorio estratificado por cuotas de edad y sexo a partir de la tarjeta sanitaria individual. Se ha medido la calidad percibida con un cuestionario validado y fiable, utilizado anteriormente con fines similares por el Ministerio de Sanidad y Consumo. RESULTADOS: Se analizan un total de 295 encuestas, 147 a varones y 148 a mujeres. La media de edad es de 48,83 años (DE: 18,77 para el Centro de Salud de Motilla, en Centro de Salud de Cardenete es de 61,93 años (DE: 15,17. La media de frecuencias mensuales de visitas para Centro de Salud de MP ha sido de 1,56 (DE: 1,91; esta media para el Centro de Salud de Cardenete ha sido:2,49 (DE: 4,27. La media de frecuencias semanales para el Centro de Salud de MP ha sido: 0,32 (DE: 0,66; para el Centro de Salud de Cardenete ha sido: 0,49 (DE: 1,03. El tiempo de espera en el Centro de Salud de MP ha sido: 10,86 minutos (DE: 8,27; en el Centro de Salud de Cardenete: 7,88 (DE: 4,55. 83,4 % de los usuarios de los dos Centros de Salud de conocen la posibilidad de libre elección de médico de cabecera. Se han encontrado diferencias estadísticamente significativas en 11 de los 21 ítems estudiados sobre calidad percibida de que consta el cuestionario CONCLUSIÓN. Los resultados de los componentes de la atención según el análisis factorial de los ítems de calidad percibida son coincidentes con los resultados de calidad percibida. De los dos grupos de usuarios estudiados, los que perciben

  20. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

    OpenAIRE

    Alvear-Sedán Ciro; Barboza-Ubarnes, Miryam; Bonillas-Fierro Miguel [q.e.p.d

    2011-01-01

    CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límite...

  1. Influência dos estilos parentais no desenvolvimento do comportamento criminal dos reclusos

    OpenAIRE

    Silva, Andrea Venícia Santos Reis

    2010-01-01

    A presente investigação procura contribuir para um conhecimento mais aprofundado de uma problemática complexa – os estilos parentais e o desenvolvimento do comportamento criminal. Procura-se compreender em que medida os estilos parentais estão relacionados e influenciam o desenvolvimento do comportamento criminal de reclusos, controlando pelas características sócio-demográficas e antecedentes familiares dos sujeitos. O estudo engloba a população reclusa do Estabelecimento Prisional de C...

  2. avaliação dos riscos para a saúde dos consumidores

    OpenAIRE

    Pereira, Tiago Filipe Garcia

    2014-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas A popularidade das novas substâncias psicoativas, conhecidas como “drogas legais”, está em contínuo crescimento, particularmente entre adolescentes e adultos jovens. Estes produtos são normalmente vendidos via Internet e em lojas designadas por “smart shops”. A internet desempenha um papel importante no estímulo para o ...

  3. NON EPITHELIAL TUMORS OF OVARY

    Directory of Open Access Journals (Sweden)

    Rajani

    2015-05-01

    Full Text Available BACKGROUND: Non epithelial tumors of ovary are uncommon tumors and may generate difficulty in establishing a diagnosis. Small cell carcinoma (SCC of the female genital tract and primary lymphoma of ovary is even rarer, constituting less than 1% of all gynecologic malignancies. These tumors have poor prognosis. In the present study an effort was made to review these tumors in our Institute. AIMS: To know the prevalence, age distribution, clinical presentation and morphological appearance of these tumors. MATERIALS AND METHODS: Analyzed 34 cases of non - epithelial tumors of ovary received in the department of pathology during a period of three years. Specimens were grossed, routinely processed under standardized conditions for paraffin embedding and stained with hematoxylin and eosin using standard procedures. Special stains and Immunohistochemistry was done where ever necessary. RESULTS: A total of ovarian tumors received during this period were 136. Non epithelial tumors of ovary constituted 34/136 (25%, of the ovarian neoplasms. Germ cell tumors constituted 23/34(67.64% followed by sexcord stromal tumors 7/34 (20.58%. Among the rare tumors we encountered a case of small cell carcinoma, primary lymphoma of ovary and 2 cases of Krukenberg tumors of ovary 2/34 (5.88%. CONCLUSION: Small cell carcinoma and primary lymphoma are morphologically similar to sex cord stromal tumors and germ cell tumors, may pose significant problems in establishing the correct diagnosis. Immunohistochemistry is a must to diagnose these lesions as they have grave prognosis.

  4. "Osseous tumors of the hand "

    Directory of Open Access Journals (Sweden)

    "Farzan M

    2002-08-01

    Full Text Available The majority of osseous tumors of the hand are benign. The surgeon who evaluates and treats osseous tumors of the hand has to be familiar with limb anatomy, tumor biology, various presentations of the tumors and the range of treatment possibilities and their limitations. Lesions in the hand more often present earlier in their course than those at other sites, just because they are more likely to superficial and easily noticed. A review of all cases of osseous tumors of the hand, seen by a hand surgeon over the last 10 years, at Imam Khomeini hospital was performed. Among 55 cases with osseous tumors of hand, 48 primary benign bone tumors, 3 primary malignant bone tumors, and 4 metastatic bone tumors were found. Enchondroma was the most common benign bone tumor followed by osteoid osteoma, osteoblastoma, aneurismal bone cyst, giant cell tumor, epidermoid cyst, and osteochondroma. There were two chondrosarcoma and one Ewing’s sarcoma as primary malignant bone tumors. Metastasis to the hand from colon, esophagus, and breast were also found. There were also two cases with Brown tumor secondary to hyperparathyroidism, we conclude that a variety of osseous tumors could occur in the hand, and usually they are benign. Although malignant neoplasms in the hand that arise from tissues other than the skin are very rare, the hand may be the site of distant breast, lung, kidney, esophagus, or colon adenocarcinoma metastases, most of which have a predilection for the distal phalanges.

  5. Schwannoma vestibular: involução tumoral espontânea Vestibular Schwannoma: spontaneous tumor involution

    Directory of Open Access Journals (Sweden)

    Norma de Oliveira Penido

    2007-12-01

    Full Text Available A história natural dos schwannomas vestibulares ainda não está totalmente elucidada, mas sua maioria tende a apresentar crescimento lento, muitos permanecendo sem sintomas durante toda a vida do paciente. Cerca de 69% deste tipo de tumor diagnosticados não apresentam crescimento e, destes, 16% chegam a apresentar regressão tumoral. Considerando os tumores que apresentam crescimento, cerca de 70% crescem menos de 2 mm ao ano. O avanço nos métodos de diagnóstico por imagem, particularmente à ressonância magnética com contraste de gadolínio, permite o diagnóstico cada vez mais de lesões com sintomas mínimos e tamanhos menores. O tratamento de escolha para estes tumores ainda é a ressecção completa do tumor. As técnicas cirúrgicas apresentaram grande avanço nas últimas décadas, o que possibilitou diminuição da mortalidade. Assim, a cirurgia, que antes tinha como objetivo apenas a ressecção completa do tumor, agora visa também à preservação da audição e da função do nervo facial. Considerações finais: Considerando-se sua história natural, abre-se a possibilidade de uma conduta conservadora já que o ritmo de crescimento no primeiro ano após o diagnóstico prediz o comportamento do tumor nos próximos anos. A conduta conservadora não implica em repúdio à cirurgia, devendo ser utilizada em casos de aumento tumoral, piora dos sintomas ou desejo do paciente. Além disso, em relatos de literatura não há diferença estatisticamente significante entre os pacientes submetidos à cirurgia logo após o diagnóstico ou após conduta conservadora inicial, no que diz respeito às seqüelas pós-operatórias.The natural history of Vestibular Schwannomas (VS is yet not totally known, but most of them have the tendency to slow growth, sometimes without any kind of symptoms during the individual’s entire time. About 69% of diagnosed VS do not grow at all and 16% of these can even regress. Considering tumors that grow

  6. Extradigital Glomus Tumor of Thigh

    Directory of Open Access Journals (Sweden)

    Kemal Beksaç

    2015-01-01

    Full Text Available Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies. They represent around 1–5% of all soft-tissue tumors. High temperature, sensitivity, and pain and localized tenderness are the classical triad of symptoms. Most glomus tumors represent in the subungual area of digits. Extradigital glomus tumors are a very rare entity. There are rare cases of these tumors reported to be in shoulder, elbow, knee, wrist, even stomach, colon, and larynx. We are reporting a case of a glomus tumor on thigh and discuss the histological and immunohistochemical features.

  7. A institucionalização da câmara dos deputados dos Estados Unidos

    Directory of Open Access Journals (Sweden)

    Nelson W. Polsby

    2008-06-01

    Full Text Available O artigo analisa como se deu a institucionalização da Câmara dos Deputados dos Estados Unidos, desde seu início, no final do século XVIII, até meados do século XX. Esse processo é analisado a partir de três variáveis fundamentais: 1 a delimitação funcional em relação a outras organizações, particularmente políticas; 2 a relativa complexidade da instituição, ou seja, até que ponto suas funções são internamente separadas em alguma base regular e explícita; 3 o universalismo e o automatismo nos procedimentos adotados para conduzir seus diversos assuntos internos. Cada uma dessas variáveis é sucessivamente examinada do ponto de vista histórico ao longo do artigo; a título de conclusão, apresentam-se algumas observações especulativas sobre causas, conseqüências e possíveis lições que se pode tirar da institucionalização da Câmara.

  8. O valor da moeda e a teoria dos preços dos ativos

    Directory of Open Access Journals (Sweden)

    Fernando de Holanda Barbosa

    2005-06-01

    Full Text Available Este artigo usa o enfoque da teoria dos preços dos ativos na determinação do preço da moeda para apresentar uma resenha concisa sobre os seguintes tópicos da teoria monetária: i preço da moeda: bolhas versus fundamentos; ii equilíbrio múltiplo; iii indeterminação do nível de preço ; iv quantidade ótima de moeda ; v hiperinflação; vi substituição de moeda e vii rigidez do preço no curto prazo.The price of money, as the price of any financial asset, can be determined through asset pricing theory. Based on this approach, this paper presents a concise survey of the following topics of monetary theory: i price of money: bubbles versus fundamentals; ii multiple equilibria; iii price level indeterminacy; iv optimum quantity of money; v hyperinflation; vi currency substitution, and vii price of money rigidity.

  9. Hyaluronan Promotes Tumor Lymphangiogenesis and Intralymphantic Tumor Growth in Xenografts

    Institute of Scientific and Technical Information of China (English)

    Li-Xia GUO; Ke ZOU; Ji-Hang JU; Hong XIE

    2005-01-01

    Hyaluronan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, has been implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mice, then angiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for plateletendothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 respectively.Interestingly, we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphatic vessels, but has little effect on tumor angiogenesis. Moreover, HA also promotes intralymphatic tumor growth, although it is not sufficient to potentiate lymphatic metastasis. These results suggest that HA,which is elevated in most malignant tumor stroma, may also play a role in tumor progression by promoting lymphangiogenesis.

  10. Tumor ablations in IMRI

    Institute of Scientific and Technical Information of China (English)

    Roberto Blanco Sequeiros

    2002-01-01

    @@ IntroductionMagnetic resonance imaging based guidance control and monitoring of minimally invasive intervention has developed from a hypothetical concept to a practical possibility. Magnetic-resonance-guided interstitial therapy in principle is defined as a treatment technique for ablating deepseated tumors in the human body.

  11. Intracardiac tumor causing

    Directory of Open Access Journals (Sweden)

    Christopher P. Jordan

    2016-07-01

    Full Text Available The following report describes the case of newborn girl with an asymptomatic systolic murmur, which on imaging revealed a nearly obstructive mass in the left-ventricular outflow tract. The mass was resected and found to be consistent with a rhabdomyoma. Here, we describe the pathologic and clinical characteristics of this tumor.

  12. Tumor Treated by Endoscopy

    Science.gov (United States)

    Choi, Young; Kwak, Jae Man; Chung, So Hak; Jung, Gu Hee

    2014-01-01

    Background This study was conducted to examine the clinical usefulness and efficacy of endoscopic curettage on benign bone tumor. Methods Thirty-two patients (20 men and 12 women) with benign bone tumor were included in the study. The patients were aged between five and 76 years; the mean follow-up period was 27.05 months (range, 9.6 to 39.9 months). The primary sites include simple bone cyst (9 cases), fibrous dysplasia (6 cases), enchondroma (5 cases), non-ossifying fibroma (4 cases), bone infarct (3 cases), aneurysmal bone cyst (1 case), chondroblastoma (1 case), osteoblastoma (1 case), intraosseous lipoma (1 case), and Brodie abscess (1 case). A plain radiography was performed to assess the radiological recovery. Radiological outcomes, including local recurrence and bone union, were evaluated as excellent, good, poor, and recurred. Results In our series, there were 27 cases (84.4%) of good or better outcomes, six cases (18.8%) of complications (4 local recurrence, 1 wound infection, and 1 pathologic fracture). Conclusions Our results showed that endoscopic curettage and bone graft had a lower rate of recurrence and a higher cure rate in cases of benign bone tumor. It can, therefore, be concluded that endoscopic curettage and bone graft might be good treatment modalities for benign bone tumors. PMID:24605192

  13. Tumor interstitial fluid

    DEFF Research Database (Denmark)

    Gromov, Pavel; Gromova, Irina; Olsen, Charlotta J.;

    2013-01-01

    secretion, non-classical secretion, secretion via exosomes and membrane protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for the discovery of molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper...

  14. Pituitary: Secretory Tumors

    Science.gov (United States)

    ... is caused by the excess secretion of growth hormone (GH). It can cause noticeable changes in your appearance, ... medication approved for acromegaly. Instead of suppressing excess GH production by the pituitary tumor, it works to stop the hormone from acting on the body, but does not ...

  15. Targeting thapsigargin towards tumors

    DEFF Research Database (Denmark)

    Doan, Nhu Thi Quynh; Paulsen, Eleonora Sandholdt; Sehgal, Pankaj;

    2015-01-01

    substrates for either prostate specific antigen (PSA) or prostate specific membrane antigen (PSMA) prodrugs were created, which selectively affect prostate cancer cells or neovascular tissue in tumors. One of the prodrug is currently tested in clinical phase II. The prodrug under clinical trial has been...

  16. Radioembolization of liver tumors

    NARCIS (Netherlands)

    Hoven, A.F. van den

    2016-01-01

    Radioembolization is a therapy during which radioactive microspheres are administered through a microcatheter placed in the hepatic arterial vasculature in order to irradiate liver tumors from within. In the past decennium, this treatment has evolved as a safe and effective treatment option for pati

  17. Melhoria da disponibilidade dos equipamentos para o aumento do OEE

    OpenAIRE

    Valente, Filipe Daniel Silva

    2012-01-01

    Este trabalho tem como tema central a eficiência global dos equipamentos (ou Overall Equipment Efficiency - OEE), um indicador que surgiu na metodologia TPM – Total Productive Maintenance. A utilização do OEE permite às empresas analisar as reais condições de utilização dos seus activos, através da identificação das seis grandes perdas dos equipamentos, reflectidas nos índices de disponibilidade, eficiência e qualidade. A multiplicação destes índices resulta no valor do OEE....

  18. Do valor da vida, dos interesses, do sujeito

    OpenAIRE

    Marciano Adilio Spica

    2004-01-01

    O presente artigo versa sobre um dos mais polêmicos temas da ética prática, a saber, a inclusão de seres não-humanos na esfera da moral. Busca-se aqui reconstruir os argumentos de Peter Singer e Holmes Rolston III sobre o valor da vida, dos interesses e do sujeito. Ambos os autores defendem um alargamento da esfera moral, tradicionalmente reduzida somente aos seres da espécie humana. Suas teorias, porém, entram em conflito quando se trata dos limites da esfera moral. Enquanto Singer def...

  19. Atitudes dos residentes face a festivais de música

    OpenAIRE

    Gomes, José Manuel Mano da Silva

    2013-01-01

    O principal objetivo deste projeto de investigação é analisar o apoio dos residentes da cidade de Barcelos face ao evento Milhões de Festa. A satisfação do objetivo referido implicou a realização de uma reflexão teórica, a partir de uma pesquisa bibliográfica focada no conceito de evento, nas perceções e atitudes dos residentes face aos eventos e nos fatores que influenciam a atitude dos residentes face aos eventos. Com base nesta reflexão teórica foi possível desenvolver um...

  20. Retroperitoneal calcifying fibrous tumor mimicking an adrenal tumor

    OpenAIRE

    Prochaska, Erica C.; Sciallis, Andrew P.; Miller, Barbra S.

    2016-01-01

    Establishing the etiology of a retroperitoneal tumor may be difficult due to close proximity of multiple organs. Evaluation of retroperitoneal tumors often leads to surgery, many times to obtain a definitive diagnosis and rule out malignancy. Calcifying fibrous tumors (CFT) are very rare soft tissue tumors occurring most often in young patients. They are most often found arising in the thoracic cavity, mediastinum, abdominal cavity and extremities and usually have a benign clinical course. Ma...

  1. Epidemiological features of brain tumors

    Directory of Open Access Journals (Sweden)

    Živković Nenad

    2013-01-01

    Full Text Available Brain tumors account for 1.4% of all cancers and 2.4% of all cancer-related deaths. The incidence of brain tumors varies and it is higher in developed countries of Western Europe, North America, Australia and New Zealand. In Serbia, according to data from 2009, malignant brain tumors account for 2. 2 of all tumors, and from all cancer­related deaths, 3.2% is caused by malignant brain tumors. According to recent statistical reports, an overall incidence of brain tumors for benign and malignant tumors combined is 18.71 per 100,000 persons/year. The most common benign brain tumor in adults is meningioma, which is most present in women, and the most common malignant tumor is glioblastoma, which is most present in adult men. Due to high mortality, especially in patients diagnosed with glioblastoma and significant brain tumor morbidity, there is a constant interest in understanding its etiology in order to possibly prevent tumor occurrence in future and enable more efficient treatment strategies for this fatal brain disease. Despite the continuously growing number of epidemiological studies on possible factors of tumor incidence, the etiology remains unclear. The only established environmental risk factor of gliomas is ionizing radiation exposure. Exposure to radiofrequency electromagnetic fields via cell phone use has gained a lot of attention as a potential risk factor of brain tumor development. However, studies have been inconsistent and inconclusive, so more definite results are still expected.

  2. Intramedullary tumors in children: analysis of 24 operated cases Tumores intramedulares em crianças: análise de 24 casos operados

    Directory of Open Access Journals (Sweden)

    Ricardo de Amoreira Gepp

    2010-06-01

    Full Text Available Intramedullary tumors are rare. The authors reviewed 24 cases operated between 1996 and 2006. The study assessed the clinical characteristics and surgical results based upon the neurological function. METHOD: Medical records of patients with intramedullary astrocytoma and ependymoma were reviewed. The minimal follow up time was 6 months and, at the end of this period, a comparative analysis of the neurological function was performed based using the McCormick scale score. RESULTS: Most patients had astrocytoma (75%. Male gender was more prevalent (58.3%. The most common type of tumor was graded as I or II, and in three cases these were malignant. The total resection of the tumor was achieved in 20.8% of the cases. The statistical analysis did not show a statistically significant difference between preoperative and postoperative grades at McCormick scale. CONCLUSION: The authors concluded that microsurgery to intramedullary tumors did not significantly alter the neurological function after six months.Os tumores intramedulares são doenças raras. Os autores analisaram 24 casos operados entre 1996 e 2006. O estudo analisou as características clínicas e o resultado da cirurgia quanto à função neurológica. MÉTODO: Foram analisados pacientes com astrocitomas e ependimomas intramedulares. O tempo mínimo de acompanhamento foi de 6 meses e ao final deste período foi realizada a avaliação comparativa da variação do estado neurológico baseado na escala de McCormick. RESULTADOS: A maioria dos pacientes era de astrocitoma (75%. O gênero masculino foi mais prevalente (58,3%. A maioria dos tumores era de grau I ou II, 3 casos eram malignos. A ressecção total do tumor ocorreu em 20,8% dos casos. A avaliação estatística demonstrou que não houve diferença significativa entre o estado neurológico na escala de McCormick pré-operatória e pós-operatória. CONCLUSÕES: Os autores concluem que a microcirurgia para ressecção dos tumores

  3. Tumor estromal gastrointestinal: análise de fatores relacionados ao prognóstico Gastrointesinal stromal tumor: analysis of factors related to the prognostic

    OpenAIRE

    Rodrigo Panno Basilio de Oliveira; Vera Lucia Pannain; Pedro Eder Portari Filho; Alemar Roge Salomão; Antonio Carlos Iglesias; Carlos Alberto Basilio de Oliveira

    2007-01-01

    OBJETIVO: estudar os critérios morfológicos e imunoistoquímicos relacionados ao prognóstico dos tumores estromais gastrointestinais. MÉTODOS: o estudo foi retrospectivo de 42 casos de tumor estromal gastrointestinal (GIST). Vinte e cinco casos foram obtidos no arquivo do Serviço de Anatomia Patológica do Hospital Universitário Gaffrée e Guinle e os outros dezessete, do Serviço de Anatomia Patológica do Hospital Universitário Clementino Fraga Filho. RESULTADOS: de acordo com a análise univaria...

  4. Síndrome dos nervos cranianos por glioma do tronco cerebral: Estudo anátomo-clínico de um caso

    Directory of Open Access Journals (Sweden)

    J. Lamartine de Assis

    1945-03-01

    Full Text Available Trata-se de um caso de glioma (astrocitoma fibrilar do segmento hemibulbo-protuberancial esquerdo, e cujo quadro clínico foi dos mais polimorfos, dada a topografia e extensão do tumor. As diversas síndromes clínicas permitiram estabelecer o diagnóstico topográfico, o qual foi totalmente comprovado pela demonstração anátomo-patológica.

  5. Neurogenic tumors of the stomach

    International Nuclear Information System (INIS)

    The general and radiologic features of neurogenic tumors of the stomach are reviewed in connection with 18 cases (16 benign and 2 maglignant tumors). Such neurogenic tumors are rare in the stomach, representing less than 0.5% of all tumors. Solitary neurogenic tumors must be differentiated from those encountered during von Recklinghausen's disease. Radiological or endoscopic examination can generally determine the benign or malignant nature of solitary neurogenic tumors, which are essentially represented by schwannomas. Since these tumors are submucosal, a deep biopsy is imperative; furthermore, since such tumors are subject to hemorrhage, prior investigation by CT appears advisable to detect possible hypervascularization after injection of contrast material. For patients with von Recklinghausen's disease, a neurofibroma is usually diagnosed when faced with a digestive hemorrhage. Radiological exploration of the entire digestive tract appears essential to confirm the solitary nature of the gastric lesion and to be sure it is responsible for the clinical symptoms. (orig.)

  6. How Are Wilms Tumors Diagnosed?

    Science.gov (United States)

    ... at under a microscope. The cells in Wilms tumors have a distinct appearance when looked at this way. Doctors also look at the sample to determine the histology of the Wilms tumor (favorable or unfavorable), as was described in the ...

  7. What Are Lung Carcinoid Tumors?

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » What are lung carcinoid tumors? Share this Page Close Push escape to close share window. Print ...

  8. Neuroendocrine tumors of the pancreas.

    LENUS (Irish Health Repository)

    Davies, Karen

    2009-04-01

    Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies. They are broadly classified into either functioning tumors (insulinomas, gastrinomas, glucagonomas, VIPomas, and somatostatinomas) or nonfunctioning tumors. The diagnosis of these tumors is difficult and requires a careful history and examination combined with laboratory tests and radiologic imaging. Signs and symptoms are usually related to hormone hypersecretion in the case of functioning tumors and to tumor size or metastases with nonfunctioning tumors. Surgical resection remains the treatment of choice even in the face of metastatic disease. Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.

  9. Neuroendocrine tumors of the pancreas.

    LENUS (Irish Health Repository)

    Davies, Karen

    2012-02-01

    Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies. They are broadly classified into either functioning tumors (insulinomas, gastrinomas, glucagonomas, VIPomas, and somatostatinomas) or nonfunctioning tumors. The diagnosis of these tumors is difficult and requires a careful history and examination combined with laboratory tests and radiologic imaging. Signs and symptoms are usually related to hormone hypersecretion in the case of functioning tumors and to tumor size or metastases with nonfunctioning tumors. Surgical resection remains the treatment of choice even in the face of metastatic disease. Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.

  10. Biopsy in Musculoskeletal Tumors

    Directory of Open Access Journals (Sweden)

    Mohammad Gharehdaghi

    2014-09-01

    Full Text Available Diagnosis of bone tumors is based on careful evaluation of clinical, imaging and a pathologic findings. So the biopsy of bone and soft tissue sarcomas is the final step in evaluation and a fundamental step in the diagnosis of the lesion. It should not be performed as a shortcut to diagnosis (1. The biopsy should be performed in order to confirm the diagnosis and differentiate among few diagnoses after careful staged studies. Real and artificial changes in imaging studies will be superimposed after performing biopsy, which may alter the interpretation if done after biopsy is taken (1. The correct management of a sarcoma depends on the accurate diagnosis. Inadequate, inapprppriate, or inaccurate non-representative biopsy leads to poorer outcome in terms of survivorship and limb salvage. An incorrect, unplanned incision and biopsy may unnecessarily contaminate uninvolved compartments which may convert a salvageable limb to amputation. Anatomic approach along with the proper biopsy techniques may lead to success or catastrophe. It is clear that in patients with inappropriate biopsy, the chance of the need to change the treatment to more radical than would originally be expected is significantly higher. Also it is more probable to need to  convert curative to palliative treatment and to require adjuvant radiotherapy in patients with inappropriate biopsies. Patients with sarcoma are best served by early referral to a specialized center where staged investigations and biopsy can be performed with minimal morbidity (3. Open biopsy is still considered the gold standard; however, recent studies suggest comparable results with percutaneous core needle biopsy. Our study on 103 consecutive CNB and open biopsy showed comparable results as well. Surgeons need to answer to two questions prior to performing a biopsy: 1-          Where is the best part of the lesion to be biopsied? 2-          What is the safest route without contaminating

  11. Sobriedade e embriaguez: a luta dos soldados de Cristo contra as festas dos tupinambás

    Directory of Open Access Journals (Sweden)

    João Azevedo Fernandes

    2007-01-01

    Full Text Available O artigo analisa a luta dos missionários cristãos, em especial os jesuítas, contra as festas e as bebidas alcoólicas dos tupinambás. Eles perceberam que, nestas festas, a cultura tupinambá, principal obstáculo à evangelização, se renovava e se reafirmava constantemente. O artigo também explora as principais estratégias usadas pelos europeus para alcançar o objetivo de extinguir as festas dos índios.

  12. Influência dos estilos musicais na atitude dos clientes: evidências experimentais em uma loja varejista

    OpenAIRE

    Gabriela Souza Assis; Janaina de Moura Engracia Giraldi

    2012-01-01

    O presente trabalho teve como objetivo comparar a influência dos diferentes estilos musicais no comportamento e na atitude dos clientes. Foi realizado um experimento em uma loja varejista na cidade de Uberaba (MG). Neste experimento, foram testados três estilos musicais (sertanejo, axé e pop rock) e a ausência de música, como grupo controle. Os dados foram coletados por meio de um questionário estruturado com questões que procuraram medir a atitude do cliente através dos três componentes (afe...

  13. Growth factors in tumor microenvironment

    OpenAIRE

    Zhang, Xuejing; Nie, Daotai; Chakrabarty, Subhas

    2010-01-01

    Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also d...

  14. Tumor suppressor and hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Juliette Martin; Jean-Frangois Dufour

    2008-01-01

    A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

  15. Tecnologia dos sonhos em Artemidoro, Freud, Jung e nos Warlpiri

    Directory of Open Access Journals (Sweden)

    Abrahão de Oliveira Santos

    2014-08-01

    Full Text Available Apresentaremos distintas tecnologias dos sonhos: em Artemidoro, Freud, Jung e nos Warlpiri. Artemidoro revela a mensagem onírica imprescindível à condução do cidadão, com os elementos das instituições, da cidade, do cosmo. Com Freud, no moderno mundo europeu, o sonho recebe o sentido da interioridade. Outra leitura é de Carl Jung. O uso dos sonhos tem seu sentido histórico, se relacionando com as práticas de governo, os modos de condução da vida e da cidade. Para além das tradições eurodescendentes e mentalistas vigentes, apresentaremos a tecnologia coletiva dos sonhos dos Warlpiri e uma nova possibilidade de lidarmos com a experiência onírica.

  16. Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control

    International Nuclear Information System (INIS)

    Background and purpose: The causes of tumor response variation to radiation remain obscure, thus hampering the development of predictive assays and strategies to decrease resistance. The present study evaluates the impact of host tumor stromal elements and the in vivo environment on tumor cell kill, and relationship between tumor cell radiosensitivity and the tumor control dose. Material and methods: Five endpoints were evaluated and compared in a radiosensitive DNA double-strand break repair-defective (DNA-PKcs−/−) tumor line, and its DNA-PKcs repair competent transfected counterpart. In vitro colony formation assays were performed on in vitro cultured cells, on cells obtained directly from tumors, and on cells irradiated in situ. Permanent local control was assessed by the TCD50 assay. Vascular effects were evaluated by functional vascular density assays. Results: The fraction of repair competent and repair deficient tumor cells surviving radiation did not substantially differ whether irradiated in vitro, i.e., in the absence of host stromal elements and factors, from the fraction of cells killed following in vivo irradiation. Additionally, the altered tumor cell sensitivity resulted in a proportional change in the dose required to achieve permanent local control. The estimated number of tumor cells per tumor, their cloning efficiency and radiosensitivity, all assessed by in vitro assays, were used to predict successfully, the measured tumor control doses. Conclusion: The number of clonogens per tumor and their radiosensitivity govern the permanent local control dose

  17. Tumor Microenvironment in the Brain

    Energy Technology Data Exchange (ETDEWEB)

    Lorger, Mihaela [Leeds Institute of Molecular Medicine, University of Leeds, St. James’s University Hospital, Beckett Street, Leeds, LS9 7TF (United Kingdom)

    2012-02-22

    In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.

  18. Apoptosis in irradiated murine tumors.

    Science.gov (United States)

    Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E

    1991-09-01

    Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors.

  19. Apoptosis in irradiated murine tumors.

    Science.gov (United States)

    Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E

    1991-09-01

    Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors. PMID:1886987

  20. Tumor Budding in Colorectal Carcinomas

    Directory of Open Access Journals (Sweden)

    Sevda SERT BEKTAŞ

    2012-01-01

    Full Text Available Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated.Material and Method: Haematoxylin and eosin stained slides of 73 cases with colorectal carcinoma were retrospectively evaluated for the presence and intensity of tumor budding by 2 observers. After the specimens were assessed, the highest density of tumor budding area was counted in a microscopic field of x200. Cases were separated into 2 groups according to tumor budding density as low grade (<10 and high grade (≥10. The relationship of these groups with depth of tumor invasion, histological grade, vascular invasion and lymph node involvement was investigated.Results: Of the 73 colorectal carcinoma cases, 33 (45.2% had low and 40 (54.8% had high grade tumor budding density, respectively. There was a statistically significant relationship between high grade tumor budding density and histological grade (p=0.042, lymph node involvement (p=0.0001 and vascular invasion (p=0.0034.Conclusion: High grade tumor budding density is associated with aggressive phenotypical features in colorectal carcinoma.

  1. SEGUNDA TELA: A INTERNET PERVASIVA COMO POSSIBILIDADE DE EXTENSÃO DOS CONTEÚDOS TELEVISUAIS

    Directory of Open Access Journals (Sweden)

    Adriana Pierre Coca

    2013-12-01

    Full Text Available Este artigo se alicerça, sobretudo, no conceito do fenômeno segunda tela (PROULX; SHEPATIN, 2012. Analisamos como as emissoras de TV aberta brasileiras vêm se comportando na interação com o ciberespaço. Partimos do pressuposto que, na reconfiguração dos modos de ver televisão; a internet, por ser cada vez mais um meio pervasivo, se torna uma aliada e não um perigo a hegemonia televisual. A transmidiação como apontada por Henry Jenkins (2009 está sendo colocada em prática com entusiasmo e as redes sociais, por exemplo, já se convertem em índices que mostram o reflexo do intenso diálogo entre a TV e a internet.

  2. MR findings of ovarian tumors with hormonal activity, with emphasis on tumors other than sex cord-stromal tumors

    International Nuclear Information System (INIS)

    Sex cord-stromal tumors including granulosa cell tumor, thecoma, Sertoli stromal cell tumor and steroid cell tumor are noted for their hormonal activity. However, there are many kinds of ovarian tumors other than sex cord-stromal tumors and tumor-like conditions with endocrine manifestations. Cross-sectional imaging, especially MR, can provide precise features of ovarian tumors and uterine morphological change even in a clinically latent excess of estrogen. In this article, we demonstrate typical imaging findings of ovarian tumors with hormonal activity. We also shortly explain the mechanism of the virilization and hyperestrogenism caused by ovarian tumors and tumor-like conditions

  3. Dos madres adolescentes, dos vínculos: ¿qué marca la diferencia?

    Directory of Open Access Journals (Sweden)

    Pierina Traverso K.

    2007-06-01

    Full Text Available Se presenta un estudio de caso de dos madres adolescentes de la misma edad (17 años, con el cual se intenta explorar las representaciones maternas y las interacciones madre-bebe, es decir, las distintas maneras de “estar con” el bebe. El estudio pretende discutir que la maternidad adolescente en sí misma no es un factor de riesgo, sino que otras variables moderadoras como la calidad de las redes de sostenimiento y la función reflexiva con que cada joven madre cuenta. Las representaciones maternas fueron evaluadas a través de una entrevista semi-estructurada sobre representaciones maternas (Traverso, 2006 y las interacciones madre-bebe fueron medidas y filmadas a través del Mother-Infant Global-Ratings para dos y cuatro meses (Murray, Fiori-Cowley & Cooper, 1996.---A case study of two adolescent mothers of the same age is presented (17 years old with which it is intended to explore the maternal representations and mother-baby interactions, that is, the different ways of “being with” a baby. The study pretends to discuss that it is not adolescent motherhood in itself a risk factor, but other mediating variables such as supportnetwork and the reflective function with which each young mother counts. Maternal representations were assessed through a semi-structured interview about maternal representations (Traverso, 2006 and the mother-infant interactions were measured and filmed through the Mother-Infant Global Ratings for two and four months (Murray, Fiori-Cowley & Cooper, 1996.

  4. Large-sized kidney tumor mimicking an extraorgan retroperitoneal tumor

    Directory of Open Access Journals (Sweden)

    I. A. Reva

    2015-03-01

    Full Text Available The retroperitoneal space may be a site for a broad spectrum of both rare benign and malignant tumors that are in turn a focus of primary or metastatic involvement. Sarcomas, lymphomas, and different epithelial tumors (of the kidney, adrenal, and pancreas constitute the bulk of retroperitoneal tumors. Detection of a large-sized tumor located at one of the renal poles may raise the question of whether this mass is a kidney tumor or an extraorgan retroperitoneal tumor adjacent to or growing into the kidney. In view of significant differences in treatment procedures for various retroperitoneal tumors, when the origin of the mass is unknown, there is a need for an individual approach to defining the optimal therapeutic and diagnostic tactics, by attracting specialists in allied fields. 

  5. TRUS Findings of Prostate Tumor or Tumor Like Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hak Jong; Jang, Jung Min; Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2006-03-15

    Tumors or tumor-like lesions in the prostate raise questions concerning their histogenesis and they may have prognoses dissimilar to those of prostatic adenocarcinoma. Several neoplasms involving the prostate have been described and characterized in recent years. In addition to adenocarcinoma, they include mucinous cyst adenocarcinoma, neuroendocrine cancer, lymphoma, spindle cell neoplasm, squamous cell carcinoma, transitional cell carcinoma, and benign prostatic hyperplasia (BPH) mimicking malignancy. In addition, infectious conditions such as tuberculosis and some stages of prostatic abscess can also mimic prostate tumors. Radiologic findings overlap and have limited roles in the diagnoses of these entities. However, knowledge of these variable tumors and tumor-like conditions is helpful when making accurate radiologic diagnoses, which have important clinical implications for treatment and prognosis. Transrectal ultrasound (TRUS) and available pathologic images of unusual tumors and tumor- like lesions are demonstrated in this article

  6. Characterization of the Tumor Secretome from Tumor Interstitial Fluid (TIF).

    Science.gov (United States)

    Gromov, Pavel; Gromova, Irina

    2016-01-01

    Tumor interstitial fluid (TIF) surrounds and perfuses bodily tumorigenic tissues and cells, and can accumulate by-products of tumors and stromal cells in a relatively local space. Interstitial fluid offers several important advantages for biomarker and therapeutic target discovery, especially for cancer. Here, we describe the most currently accepted method for recovering TIF from tumor and nonmalignant tissues that was initially performed using breast cancer tissue. TIF recovery is achieved by passive extraction of fluid from small, surgically dissected tissue specimens in phosphate-buffered saline. We also present protocols for hematoxylin and eosin (H&E) staining of snap-frozen and formalin-fixed, paraffin-embedded (FFPE) tumor sections and for proteomic profiling of TIF and matched tumor samples by high-resolution two-dimensional gel electrophoresis (2D-PAGE) to enable comparative analysis of tumor secretome and paired tumor tissue.

  7. Characterization of the Tumor Secretome from Tumor Interstitial Fluid (TIF).

    Science.gov (United States)

    Gromov, Pavel; Gromova, Irina

    2016-01-01

    Tumor interstitial fluid (TIF) surrounds and perfuses bodily tumorigenic tissues and cells, and can accumulate by-products of tumors and stromal cells in a relatively local space. Interstitial fluid offers several important advantages for biomarker and therapeutic target discovery, especially for cancer. Here, we describe the most currently accepted method for recovering TIF from tumor and nonmalignant tissues that was initially performed using breast cancer tissue. TIF recovery is achieved by passive extraction of fluid from small, surgically dissected tissue specimens in phosphate-buffered saline. We also present protocols for hematoxylin and eosin (H&E) staining of snap-frozen and formalin-fixed, paraffin-embedded (FFPE) tumor sections and for proteomic profiling of TIF and matched tumor samples by high-resolution two-dimensional gel electrophoresis (2D-PAGE) to enable comparative analysis of tumor secretome and paired tumor tissue. PMID:27665563

  8. Adenomatoid odontogenic tumor

    International Nuclear Information System (INIS)

    A 18-year-old man had a painless swelling in the right anterior portion of maxilla for 2 years. On radiographic examination, a radiolucent region that was not associated with an unerupted tooth was seen. Small scattered radiopaque foci were seen in the cystic lumen. At second case, a 16-year-old girl had a painless swelling in the anterior portion of maxilla for 3 years. On radio graphic examination, a radiolucent region that associated with an unerupted tooth was seen. Multiple scattered radiopaque foci were seen in the radiolucent cystic lumen. With the patient under local anesthesia, well encapsulated tumors were enucleated. The diagnosis made in the pathologist's report was Adenomatoid Odontogenic Tumor, benign lesion often having distinct clinical and radiographic features.

  9. Retroperitoneal inflammatory myofibroblastic tumor

    Directory of Open Access Journals (Sweden)

    Bapsy Poonamalle P

    2005-10-01

    Full Text Available Abstract Background Inflammatory myofibroblastic tumor (IMT is a neoplasm of unknown etiology occurring at various sites. By definition, it is composed of spindle cells (myofibroblasts with variable inflammatory component, hence the name is IMT. Case presentation The present case is of a 46 years old woman presented with a history of flank pain, abdominal mass and intermittent hematuria for last 6 months. The initial diagnosis was kept as renal cell carcinoma. Finally, it turned out to be a case of retroperitoneal IMT. The patient was managed by complete surgical resection of the tumor. Conclusion IMT is a rare neoplasm of uncertain biological potential. Complete surgical resection remains the mainstay of the treatment.

  10. Inflammatory myofibroblastic tumor

    Directory of Open Access Journals (Sweden)

    Sangeeta Palaskar

    2011-01-01

    Full Text Available Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. A number of terms have been applied to the lesion, namely, inflammatory pseudotumor, fibrous xanthoma, plasma cell granuloma, pseudosarcoma, lymphoid hamartoma, myxoid hamartoma, inflammatory myofibrohistiocytic proliferation, benign myofibroblatoma, and most recently, inflammatory myofibroblastic tumor. The diverse nomenclature is mostly descriptive and reflects the uncertainty regarding true biologic nature of these lesions. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. We hereby report a case of inflammatory pseudotumor and review its inflammatory versus neoplastic behavior.

  11. Familial germ cell tumor

    OpenAIRE

    Sanju Cyriac; Rejeev Rajendranath; A. Robert Louis; Sagar, T. G.

    2012-01-01

    Familial testicular germ cell tumors are well known in literature. Only few cases are reported where both brother and sister of the same family suffered from germ cell malignancies. We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presenc...

  12. Combined tumor therapy

    International Nuclear Information System (INIS)

    This comprehensive survey of current methods and achievements first takes a look at the two basic therapies, devoting a chapter each to the surgery and radiotherapy of tumors. The principal subjects of the book, however, are the systemic, adjuvant therapy, biological therapies, hyperthermia and various other therapies (as e.g. treatment with ozone, oxygen, or homeopathic means), and psychotherapy. (MG) With 54 figs., 86 tabs

  13. Respiratory tract tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008053 Expression of PTEN gene in non-small cell lung cancer. HONG Zheng(洪征),et al. Dept Thoracic Surg, Thoracic Tumor & Tuberc Res Instit , Beijing 101149. Chin J Clin Oncol Rehabil 2007;14(6):487-490. Objective To investigate the expression of PTEN gene in non-small cell lung cancer (NSCLC) and analyze the role of PTEN gene in lung tumorigenesis. Methods Immunohistochemical stain was used to determine the expression of PTEN in

  14. Intracranial germ cell tumor

    OpenAIRE

    Kreutz, J; Rausin, L.; Weerts, E; Tebache, M; Born, J; Hoyoux, C

    2010-01-01

    Germ cell tumours represent about 3 to 8% of pediatric brain tumours. Occurrence of diabetes insipidus is common in the case of suprasellar germ cell tumors. The diagnosis may be advanced by MRI owing to the location and relatively univocal characteristics of the lesion signal. The existence of a bifocal mass developed in both suprasellar region and pineal zone is highly suggestive of a germinoma. The most important notion is to recognize that at the time of diabetes insipidus diagnosis in a ...

  15. Mouse Leydig Tumor Cells

    Directory of Open Access Journals (Sweden)

    Bo-Syong Pan

    2011-01-01

    Full Text Available Cordycepin is a natural pure compound extracted from Cordyceps sinensis (CS. We have demonstrated that CS stimulates steroidogenesis in primary mouse Leydig cell and activates apoptosis in MA-10 mouse Leydig tumor cells. It is highly possible that cordycepin is the main component in CS modulating Leydig cell functions. Thus, our aim was to investigate the steroidogenic and apoptotic effects with potential mechanism of cordycepin on MA-10 mouse Leydig tumor cells. Results showed that cordycepin significantly stimulated progesterone production in dose- and time-dependent manners. Adenosine receptor (AR subtype agonists were further used to treat MA-10 cells, showing that A1, A 2A , A 2B , and A3, AR agonists could stimulate progesterone production. However, StAR promoter activity and protein expression remained of no difference among all cordycepin treatments, suggesting that cordycepin might activate AR, but not stimulated StAR protein to regulate MA-10 cell steroidogenesis. Meanwhile, cordycepin could also induce apoptotic cell death in MA-10 cells. Moreover, four AR subtype agonists induced cell death in a dose-dependent manner, and four AR subtype antagonists could all rescue cell death under cordycepin treatment in MA-10 cells. In conclusion, cordycepin could activate adenosine subtype receptors and simultaneously induce steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells.

  16. Modeling tumor evolutionary dynamics

    Directory of Open Access Journals (Sweden)

    Beatriz eStransky

    2013-02-01

    Full Text Available Tumorigenesis can be seen as an evolutionary process, in which the transformation of a normal cell into a tumor cell involves a number of limiting genetic and epigenetic events, occurring in a series of discrete stages. However, not all mutations in a cell are directly involved in cancer development and it is likely that most of them (passenger mutations do not contribute in any way to tumorigenesis. Moreover, the process of tumor evolution is punctuated by selection of advantageous (driver mutations and clonal expansions. Regarding these driver mutations, it is uncertain how many limiting events are required and / or sufficient to promote a tumorigenic process or what are the values associated with the adaptive advantage of different driver mutations. In spite of the availability of high-quality cancer data, several assumptions about the mechanistic process of cancer initiation and development remain largely untested, both mathematically and statistically. Here we review the development of mathematical/computational models where some assumptions were tested and discuss the impact of these models to the field of tumor biology.

  17. Efeitos tardios dos praguicidas organoclorados no homem Delayed effects of organochlorine pesticides in man

    Directory of Open Access Journals (Sweden)

    Mônica Vannucci Nunes

    1998-08-01

    Full Text Available Procurou-se relacionar as informações disponíveis sobre os organoclorados e os efeitos crônicos provocados pela exposição. Os compostos organoclorados são os praguicidas mais persistentes já fabricados. Embora sejam geralmente eficientes no controle das pragas, são importantes poluentes ambientais e potenciais causas de problemas de saúde para o homem, tendo sido proibidos ou controlados na maioria dos países. Com poucas exceções, os efeitos tardios desses compostos sobre a saúde humana são difíceis de detectar, em função de dificuldades metodológicas e da extrapolação dos resultados. A genotoxicidade está entre os mais sérios dos possíveis danos causados por esses compostos e merece atenção especial, devido à natureza irreversível do processo. Outro ponto a ser considerado é o aumento na incidência de alterações no desenvolvimento do trato reprodutivo e na fertilidade masculina observada nas últimas décadas provavelmente decorrente do aumento da exposição intra-uterina a compostos estrogênicos e anti-androgênicos, como os organoclorados.Available information on organochlorines and the chronic effects of exposure to them are set out. Organochlorinated compounds are the most persistent pesticides and can be found in all ecosystems. Although they are generally efficient in pest control, they are also a potent environment pollutant and can provoke health problems in man. The evidences of the carcinogenic potential of organochlorines are controversial and insufficient, but they have been related to an increase in the incidence of some kinds of tumors, such as leukemia and solid tumors. Reproductive effects, due to anti-androgenic and estrogenic action, on embryonic virilization, the incidence of abortion and the frequency of prematurity, have also been observed. The accumulation of the organochlorines in the adipous tissue is positively correlated to the increase in aging and could be implicated in the

  18. A redução dos riscos dos pesticidas pela protecção integrada

    OpenAIRE

    Amaro, Pedro

    2003-01-01

    Os pesticidas de uso agrícola tiveram grande expansão após a 2.ª Guerra Mundial, graças à descoberta e amplo desenvolvimento e aplicação pelos agricultores dos novos pesticidas organossintéticos. A sua fácil aplicação, o apoio eficiente dos técnicos das empresas de pesticidas e, por vezes, dos serviços oficiais e as evidentes vantagens de maior eficácia e de carácter económico justificam a grande expansão do consumo destes pesticidas a partir dos anos 50, 60 e 70. É bem c...

  19. Ganglioglioma: comparison with other low-grade brain tumors Ganglioglioma: estudo comparativo com outros tumores cerebrais primarios de baixo grau

    Directory of Open Access Journals (Sweden)

    Paulo Thadeu Brainer-Lima

    2006-09-01

    Full Text Available METHOD: Forty-two patients with low-grade brain tumor and refractory epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19 and group B, patients with other low-grade tumors (n=23 (14 astrocytoma, 6 oligodendroglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastrocytoma. RESULTS: Age at seizure’s onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045. Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively. Seizure’s frequency was higher in group B (p=0.002.Computerized tomography (CT was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI was abnormal in all patients. Surgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in group B. CONCLUSION: The association of refractory epilepsy and complex partial seizures, at a relatively low frequency, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.MÉTODO: Foram estudados 42 pacientes com tumor cerebral primário de baixo grau e epilepsia refratária. A idade média foi 22,3 anos. Eles foram divididos em dois grupos: no grupo A os pacientes com ganglioglioma (n=19 e no grupo B os pacientes com outros tumores primários de crescimento lento (n=23 (14 astrocitomas, 6 oligodendrogliomas, 2 tumores desembrioblástico neuroepitelial e um xantoastrocitoma. RESULTADOS: A idade de início das crises convulsivas foi 7 anos ou menos em 73% dos pacientes no grupo A e 30,4% dos pacientes no grupo B (p=0,045. A crise convulsiva do tipo parcial complexa foi a mais identificada nos grupos A e B (94,7% versus 82%, respectivamente. A freqüência de crise foi mais alta no grupo B (p=0,002. A tomografia computadorizada

  20. Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina; Avaliacao dosimetrica de uma combinacao de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porcao distal da vagina

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Roger Guilherme Rodrigues [Real e Benemerita Sociedade Portuguesa de Beneficencia, Sao Paulo, SP (Brazil). Servico de Radioterapia Estereotactica; Carvalho, Heloisa de Andrade; Stuart, Silvia Radwanski; Rubo, Rodrigo Augusto [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radioterapia], e-mail: handrade@hcnet.usp.br; Seraide, Rodrigo Migotto [Centro de Oncologia Campinas, SP (Brazil)

    2009-07-15

    Objective: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. Materials And Methods: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. Results: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). Conclusion: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina. (author)

  1. Estudo retrospectivo de 1.647 tumores mamários em cães

    Directory of Open Access Journals (Sweden)

    José C. Oliveira Filho

    2010-02-01

    Full Text Available Tumores mamários são comuns em cães, e constituem o neoplasma mais frequente em cadelas. Este estudo tem como objetivos principais estabelecer a prevalência dos tumores mamários, e dos diferentes tipos histológicos (neoplásicos e não-neoplásicos, diagnosticados em cães no Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV-UFSM. Foram avaliados 1.304 protocolos de exames histopatológicos recebidos em 1990-2008 e 132 protocolos de necropsias realizadas em 2000-2008. Deles foram obtidos a raça, o sexo e a idade dos cães, a localização do tumor na cadeia mamária, o diagnóstico morfológico e a ocorrência de metástases. Nos protocolos de exame histopatológico, foram diagnosticados 1.495 tumores, considerando que alguns cães tinham mais de um tipo de tumor, sendo 1.465 neoplásicos e 30 não-neoplásicos. Dos neoplásicos, 390 (26,6% eram benignos e 1.075 (73,3% eram malignos, estabelecendo-se uma relação benigno: maligno de 1:2,75. Das 1.125 necropsias de cães realizadas em 2000-2008, 132 (11,6% protocolos tinham descrições de tumor de mama, perfazendo 152 diagnósticos morfológicos, dos quais 150 eram neoplásicos e dois eram não-neoplásicos. Carcinoma simples foi o tipo histológico mais prevalente tanto em biópsias como em necropsias. Nas necropsias, foram observadas metástases para linfonodos em 39 casos (29,5% e para órgãos distantes em 64 casos (53,3%.Mammary gland tumors are common in dogs and are the most common type of neoplasm of female dogs. The main purposes of this study were to establish the prevalence of the mammary gland tumors, as well as of its different histologic types (neoplastic and non-neoplastic, diagnosed in the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria. There were 1,304 biopsy reports of mammary gland tumors during 1990-2008 and 132 necropsy reports of dogs with mammary tumors in 2000-2008. Data about breed, gender, and

  2. Tumors of the optic nerve

    DEFF Research Database (Denmark)

    Lindegaard, Jens; Heegaard, Steffen

    2009-01-01

    A variety of lesions may involve the optic nerve. Mainly, these lesions are inflammatory or vascular lesions that rarely necessitate surgery but may induce significant visual morbidity. Orbital tumors may induce proptosis, visual loss, relative afferent pupillary defect, disc edema and optic...... atrophy, but less than one-tenth of these tumors are confined to the optic nerve or its sheaths. No signs or symptoms are pathognomonic for tumors of the optic nerve. The tumors of the optic nerve may originate from the optic nerve itself (primary tumors) as a proliferation of cells normally present...... in the nerve (e.g., astrocytes and meningothelial cells). The optic nerve may also be invaded from tumors originating elsewhere (secondary tumors), invading the nerve from adjacent structures (e.g., choroidal melanoma and retinoblastoma) or from distant sites (e.g., lymphocytic infiltration and distant...

  3. Tumores do tronco cerebral: estudo anatomopatológico em 35 casos de necrópsia

    Directory of Open Access Journals (Sweden)

    Carmen Lúcia Penteado Lancellotti

    1989-09-01

    Full Text Available Os tumores do tronco cerebral são raros e geralmente tratados sem diagnóstico histopatológico. Sua incidência varia na literatura entre 1,09% e 17,5% dos tumores cerebrais. O objetivo do trabalho foi relatar a casuísti desses tumores em 28500 necrópsias realizadas de 1952 a 1985 no Departamento de Anatomia Patológica da Santa Casa de São Paulo. Enfatizamos os aspectos neuropatológicos, comparamos nossos casos com os de outras séries e salientamos os tumores mais observados nessa região, com a finalidade de procurar contribuir para melhor abordagem terapêutica. Utilizamos alguns dados clínicos e, através do exame anatomopatológico, localizamos o tumor no tronco cerebral sendo o diagnóstico microscópico estabelecido segundo os critérios da Organização Mundial da Saúde. Dos 428 tumores intracranianos observados, 35 estavam localizados no tronco cerebral. Foram aqui incluídos os tumores próprios do tronco cerebral e as metástases e excluídos os tumores que infiltravam o tronco. A maior incidência ocorreu na primeira década e a causa de óbito predominante foi edema cerebral. A localização preferencial foi a ponte e o tumor mais freqüente foi o glioblas-tomia multiforme (19 casos. As metástases ficaram em segundo lugar na freqüência (9 casos, na maioria dos casos de origem pulmonar. Apesar de alguns autores se posicionarem contra a biópsia de tumor nessa região, baseando-se no alto risco cirúrgico, discordamos dessa opinião, pois acreditamos que, frente ao diagnóstico de glioma, será importante a caracterização ou não de malignidade. Ainda, não devemos deixar de considerar os diagnósticos diferenciais de processo expansivo no tronco. Enfim, com o diagnóstico anatomopatológico de glioma ou de uma das possibilidades aventadas, o procedimento terapêutico poderá ser mais adequado.

  4. Respiratory-driven lung tumor motion is independent of tumor size, tumor location, and pulmonary function

    International Nuclear Information System (INIS)

    Purpose: To determine whether superior-inferior lung tumor motion is predictable by tumor size or location, or pulmonary function test results. Methods and Materials: Superior-inferior tumor motion was measured on orthogonal radiographs taken during simulation of 22 patients with inoperable lung cancer diagnosed by orthogonal radiographs. Results: The tumor size averaged 5.5±3.1 cm (range 1.5-12 cm). Seven of 11 central tumors demonstrated some motion compared with 5 of 11 peripheral tumors. Four of 5 upper lobe tumors moved compared with 8 of 17 tumors that were either middle or lower lobe lesions. The mean fourth rib motion was 7.3±3.2 mm (range 2-15). The mean FeV1 was 1.8±1.2 (range 0.55-5.33. The mean diffusing capacity of the lung for carbon monoxide was 14.0±6.5 (range 7.8-21.9). The mean total lung capacity was 6.5±1.2 (range 3.3-8.4). None of these parameters correlated with tumor motion. Although lateral tumor motion could not be consistently determined, 1 tumor moved 10 mm anterior-posteriorly. Conclusions: Lung tumors often move significantly during respiration. Tumor motion is not predictable by tumor size or location, or pulmonary function test results. Therefore, tumor motion must be measured in all patients. Measurement in three dimensions will likely be necessary to maximize the irradiated lung volumes or choose beam arrangements parallel to the major axis of motion

  5. Study of Kidney Tumors in Younger Patients

    Science.gov (United States)

    2016-05-17

    Clear Cell Sarcoma of the Kidney; Congenital Mesoblastic Nephroma; Diffuse Hyperplastic Perilobar Nephroblastomatosis; Rhabdoid Tumor of the Kidney; Stage I Renal Cell Cancer; Stage I Wilms Tumor; Stage II Renal Cell Cancer; Stage II Wilms Tumor; Stage III Renal Cell Cancer; Stage III Wilms Tumor; Stage IV Renal Cell Cancer; Stage IV Wilms Tumor; Stage V Wilms Tumor

  6. Parallel evolution of tumor subclones mimics diversity between tumors

    DEFF Research Database (Denmark)

    Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco;

    2013-01-01

    Intratumor heterogeneity (ITH) may foster tumor adaptation and compromise the efficacy of personalized medicines approaches. The scale of heterogeneity within a tumor (intratumor heterogeneity) relative to genetic differences between tumors (intertumor heterogeneity) is unknown. To address this, we...... obtained 48 biopsies from eight stage III and IV clear cell renal cell carcinomas (ccRCC) and used DNA copy-number analyses to compare biopsies from the same tumor with 440 singletumor biopsies from The Cancer Genome Atlas (TCGA). Unsupervised hierarchical clustering of TCGA and multi-region ccRCC samples...... revealed segregation of samples from the same tumor into unrelated clusters. 25% of multi-region samples appeared more similar to unrelated samples than to any other sample originating from the same tumor. We find that the majority of recurrent DNA copy number driver aberrations in single biopsies...

  7. Modelo de tumor de pulmão em rato com o carcinossarcoma de Walker Lung tumor model in rats with Walker’s carcinosarcoma

    Directory of Open Access Journals (Sweden)

    Antero Gomes Neto

    2002-02-01

    Full Text Available OBJETIVO: Desenvolver um modelo de tumor pulmonar em ratos com o carcinossarcoma de Walker e verificar in vivo a presença de tumor por meio de tomografia computadorizada (TC. MÉTODOS: Ratos Wistar fêmeas (n=47 foram anestesiados com pentobarbital, intubados por traqueostomia e submetidos a toracotomia para injeção no parênquima pulmonar de células do tumor de Walker ou do veículo das mesmas. O estudo consistiu de duas etapas: na primeira desenvolveu-se a técnica de implante do tumor e estabeleceu-se o número de células necessário para um bom índice de pega tumoral. Na segunda etapa, determinou-se o volume do tumor em cm³ (Dxd²/2 através de TC e necropsia (6° dia do implante, e analizou-se a sobrevida dos animais. RESULTADOS: O índice de pega do tumor foi 93,3%, sendo 81,8% na primeira etapa e 100% na segunda. A mortalidade cirúrgica foi 17,0%. As medidas dos tumores foram semelhantes (0,099 vs. 0,111 cm³ na tomografia e na necropsia, respectivamente (r=0,993; pOBJECTIVE: To develop a lung tumor model in rats using Walker’s carcinosarcoma and to verify the presence in vivo of tumors using computerized tomography (CT. METHODS: Female Wistar rats (n=47 were anesthetized with pentobarbital, intubated through tracheostomy and submitted to thoracotomy; subsequently a 50-70 mu L volume containing Walker’s tumor cells, or the suspension of these same cells, was injected into the lung parenchyma. The study consisted of two phases: in the first a tumor implantation technique was developed and the number of cells required to attain a satisfactory tumor development rate was established. In the second phase, the tumor volume in cm³ (Dxd²/2 was determined through CT scan and necropsis, and the survival rates were analyzed. RESULTS: The overall tumor development rate was 93.3%, or rather, 81.1% in the first phase and 100% in the second. The surgical mortality rate was 17.0%. The average tumor volume was similar (0.099 vs. 0.111 cm

  8. Imaging in Pediatric Infratentorial Tumors

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    S. Hajiahmadi

    2008-01-01

    Full Text Available Intracranial tumors are the second cause of malignancies in childhood following leukemia. The overall incidence varies between 1:20000 and 1:100000 in different series. They are the most common solid tumors that occur in childhood .The most important diagnostic feature of an intracranial mass is its location. They can be supratentorial or infratentorial. With the exception of the first year of life, infratentorial brain tumors are more frequent than supratentorial tumors in the first decade of life. In particular, these are cerebellar low-grade astrocytomas, medulloblastomas, brain stem gliomas and ependymomas of the fourth ventricle. .Posterior fossa tumors also are readily identified with both CT and MRI. Spectroscopy in the analysis of brain tumors has recently come on the scene but may be of limited practical value when it comes to differentiating tumors. However, CT and especially MRI are the primary imaging modalities for the investigation of brain tumors. Sonography can be used in the neonates. With modern imaging, it is relatively easy to detect the presence of a tumor in most patients. The purpose of this essay is to illustrate the imaging features of various infratentorial brain tumors to make a clue for differentiation them by these features.

  9. Imaging tumors of the patella

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, R., E-mail: roberto.casadei@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Kreshak, J., E-mail: j.kreshak@yahoo.com [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rinaldi, R. [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rimondi, E., E-mail: eugenio.rimondi@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Bianchi, G., E-mail: giuseppe.bianchi@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Alberghini, M., E-mail: marco.alberghini@ior.it [Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Ruggieri, P. [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Vanel, D., E-mail: daniel.vanel@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy)

    2013-12-01

    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location.

  10. Perspectivas para a pesquisa em contabilidade: o impacto dos derivativos

    Directory of Open Access Journals (Sweden)

    Alexsandro Broedel Lopes

    2001-08-01

    Full Text Available Este artigo analisa o impacto dos instrumentos financeiros derivativos para a pesquisa em contabilidade. O impacto dos derivativos é grande independentemente da linha de pesquisa adotada. Dentro do paradigma do mercado de capitais, o papel dos derivativos como antecipadores do comportamento futuro dos preços fornece oportunidades interessantes de investigação, por exemplo. Na linha de pesquisa institucional e social o tratamento contábil de tais instrumentos é visualizado tendo-se por base a busca por poder e legitimização da profissão. As características operacionais dos produtos, ambiente de regulamentação, evolução tecnológica e outros aspectos característicos fazem desses produtos bases promissoras para investigações futuras.This paper investigates the role of derivative financial instruments for the future of financial accounting research. This impact is relevant what all major research paradigms are concerned. In capital market-based research, derivative instruments play a central role in price discovery. From the institutional and social points-of-view, derivatives are components of a greater quest for legitimization and power. Their operational features, regulatory environment, technological advances and other characteristics are turning derivatives into promising research venues.

  11. What is a pediatric tumor?

    Directory of Open Access Journals (Sweden)

    Mora J

    2012-11-01

    Full Text Available Jaume Mora1,21Department of Oncology, 2Developmental Tumor Biology Laboratory, Hospital Sant Joan de Deu, Fundacio Sant Joan de Deu, Barcelona, SpainAbstract: Working together with medical oncologists, the question of whether a Ewing sarcoma in a 25-year-old is a pediatric tumor comes up repeatedly. Like Ewing's, some tumors present characteristically at ages that cross over what has been set as the definition of pediatrics (15 years, 18 years, or 21 years?. Pediatric oncology textbooks, surprisingly, do not address the subject of defining a pediatric tumor. They all begin with an epidemiology chapter defining the types of tumors appearing at distinct stages of childhood, adolescence, and young adulthood. Describing the epidemiology of tumors in relation to age, it becomes clear that the disease is related to the phenomenon of aging. The question, however, remains: is there a biological definition of what pediatric age is? And if so, will tumors occurring during this period of life have anything to do with such biological definition? With the aim of finding an objective definition, the fundamental concepts of what defines "pediatrics" was reviewed and then the major features of tumors arising during development were analyzed. The tumors were explored from the perspective of a host immersed in the normal process of growth and development. This physiological process, from pluripotential and undifferentiated cells, makes possible the differentiation, maturation, organization, and function of tissues, organs, and apparatus. A biological definition of pediatric tumors and the infancy–childhood–puberty classification of developmental tumors according to the infancy–childhood–puberty model of normal human development are proposed.Keywords: growth and development, pediatric tumor, infant, childhood and adolescence, pubertal tumors

  12. Prognostic significance of tumor size in child osteogenic sarcoma Significado prognóstico do tamanho tumoral no osteossarcoma infantil

    Directory of Open Access Journals (Sweden)

    Marcos Almeida Matos

    2002-09-01

    Full Text Available From 1995 to 1998, twenty seven pediatric patients were included in a prospective clinical study. Their age ranging from 8.9 to 17.5 years old (mean 13.5, 20 (74% were male and 7(26% female, with a follow-up going from 3 to 39 months (average of 17. Osteogenic sarcoma arises in Knee (55.5%, ankle (26%, shoulder (11.1%, pelvis (3.7% and hip (3.7%. Tumors less than 12cm were considered being small ones, while those bigger than 12cm were considered large. .All patients were submitted to clinical, radiological, histological evaluation and graded by Enneking(5 system (13 were IIB and 8 were IIIB; treated by chemotherapeutic agents, according to "Brazillian Protocol 91" and had a local surgical control. There were carried out 9 (42.9% radical surgical interventions and 12 (57.1% surgeries of limb preservation. According to lesion size, eight (38.1% out of 14 (67.9% patients with a tumor greater than 12cm died; in contrast, none out of 7 with tumor less than 12cm relapsed or died. Authors have concluded that tumor size can be a good factor for prognosis indication, being low cost, simple, easy to reproduce and specially useful for taking pre-treatmente decisions.Entre 1995 a 1998, vinte e sete pacientes foram incluídos neste estudo clínico prospectivo. A idade variou entre 8,9 e 17,5 anos (média de 13,5, 20 (74% eram do sexo masculino e 7 (26% do sexo feminino com seguimento entre 3 e 39 meses (média de 17. O osteossarcoma incidiu no joelho (55,5%, tornozelo (26%, ombro (11,1%0, pelve (3,7% e quadril (3,7%. Tumores menores que 12cm eram considerados pequenos e maiores que 12cm eram considerados grandes. Os pacientes foram submetidos a avaliação clínica, radiológica e histológica e classificados pelo sistema de Enneking(5 (13 eram IIB e 8 eram IIIB; foram tratados com agentes quimioterápicos de acordo com o protocolo brasileiro 91 e pelo controle cirúrgico local. Foram realizadas 9 (42,9% cirurgias radicais e 12 (57,1% cirurgias de preserva

  13. Pituitary tumors containing cholecystokinin

    DEFF Research Database (Denmark)

    Rehfeld, J F; Lindholm, J; Andersen, B N;

    1987-01-01

    We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained...... increased amounts of cholecystokinin, the concentrations being extremely high in two: 8281 and 13,453 pmol per gram as compared with less than 30 pmol per gram in normal pituitary glands. The cholecystokinin concentrations were moderately increased in adenomas from another 12 patients, of whom 5 had Cushing...

  14. Angiogenesis and tumor

    Directory of Open Access Journals (Sweden)

    Kamran Mansouri

    2010-12-01

    Full Text Available Angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in the physiologic circumstances such as embryonic development, placenta formation, and wound healing. It is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. In general, angiogenesis process is a multi-factorial and highly structured sequence of cellular events comprising migration, proliferation and differentiation of endothelial cells and finally vascular formation, maturation and remodeling.Thereby, angiogenesis inhibition as a helping agent to conventional therapies such as chemotherapy and radiation has attracted the scientists’ attentions studying in this field.

  15. Abordagens cirúrgicas para os osteomas dos seios paranasais Surgical approaches to the paranasal sinuses osteoma

    Directory of Open Access Journals (Sweden)

    Fernando O. Balieiro

    2004-04-01

    Full Text Available Os osteomas são os tumores benignos mais freqüentes dos seios paranasais, apresentam crescimento lento e são em sua maioria assintomáticos. O tratamento cirúrgico destes tumores, ainda, é um tema controverso no que tange suas indicações e a escolha da abordagem cirúrgica. Existem diversas opções cirúrgicas que vão desde as abordagens externas clássicas até as transnasais assistidas por vídeo-endoscopia. Não existem indicações formais para cada uma das abordagens devendo-se sempre levar em conta o tamanho do tumor no momento da escolha da abordagem a ser empregada. OBJETIVO: Neste estudo apresentaremos seis casos de osteomas dos seios paranasais operados no Hospital Prof. Edmundo Vasconcelos, São Paulo-SP com diferentes abordagens cirúrgicas em função de peculiaridades de cada caso, discutiremos as indicações da cirurgia e também as opções cirúrgicas mostrando as vantagens e desvantagens de cada abordagem. FORMA DE ESTUDO: Estudo de série.Osteomas are the most common benign tumors arising in the paranasal sinuses, they are slow growing tumors and most part of them are assymptomatic. The surgical treatment is a controversial issue concerning their indications and surgical approach. There are several options for surgical approaches ranging from classical external surgery to intranasal endoscopic surgery. There are no formal indications for each approach and we must consider the tumor size when indicating the best approach. AIM: In this paper we will present six cases of paranasal osteomas operated at Hospital Edmundo Vasconcelos, São Paulo-SP, Brazil, with different approaches. We are also going to discuss the indications for the surgery and these approaches concerning the advantages and disadvantages of each procedure. STUDY DESIGN: Series review.

  16. Evaluation of mathematical methods and linear programming for optimization of the planning in radiotherapy; Avaliacao de metodos matematicos e programacao linear para otimizacao do planejamento em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R., E-mail: mfernandes@fmb.unesp.b [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Fac. de Medicina. Dept. de Dermatologia e Radioterapia; Fernandes, David M.; Florentino, Helenice O. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Inst. de Biociencias

    2010-07-01

    The work detaches the importance of the use of mathematical tools and computer systems for optimization of the planning in radiotherapy, seeking to the distribution of dose of appropriate radiation in the white volume that provides an ideal therapeutic rate between the tumor cells and the adjacent healthy tissues, extolled in the radiotherapy protocols. Examples of target volumes mathematically modeled are analyzed with the technique of linear programming, comparing the obtained results using the Simplex algorithm with those using the algorithm of Interior Points. The System Genesis II was used for obtaining of the isodose curves for the outline and geometry of fields idealized in the computer simulations, considering the parameters of a 10 MV photons beams. Both programming methods (Simplex and Interior Points) they resulted in a distribution of integral dose in the tumor volume and allow the adaptation of the dose in the critical organs inside of the restriction limits extolled. The choice of an or other method should take into account the facility and the need of limiting the programming time. The isodose curves, obtained with the Genesis II System, illustrate that the adjacent healthy tissues to the tumor receives larger doses than those reached in the computer simulations. More coincident values can be obtained altering the weights and some factors of minimization of the objective function. The prohibitive costs of the computer planning systems, at present available for radiotherapy, it motivates the researches to look for the implementation of simpler and so effective methods for optimization of the treatment plan. (author)

  17. Advances of Tumor Hyperthermia and Tumor Immunology in Translational Medicine

    Institute of Scientific and Technical Information of China (English)

    Hooshang Lahooti

    2015-01-01

    Hyperthermia is another important method in the treatment of tumors, secondary to surgery, radiotherapy, chemotherapy and biotherapy. It has been demonstrated the efifcacy and versatility of hyperthermia in a lot of randomized trials across various primary cancers. Both heat shock proteins (HSPs) and dendritic cells (DCs) are greatly affected by hyperthermia and closely related to the tumor immunology. Nowadays, tumor hyperthermia and tumor immunology have been attached much attention in the field of translational medicine. In this article, the action mechanism and immunological effects of hyperthermia, activation of HSPs and DCs as well as HSP- and DC-based cancer vaccine were reviewed from the perspective of translational medicine.

  18. Multiparametric classification links tumor microenvironments with tumor cell phenotype.

    Directory of Open Access Journals (Sweden)

    Bojana Gligorijevic

    2014-11-01

    Full Text Available While it has been established that a number of microenvironment components can affect the likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is poorly understood. Here we have examined microenvironment control over two different tumor cell motility phenotypes required for metastasis. By high-resolution multiphoton microscopy of mammary carcinoma in mice, we detected two phenotypes of motile tumor cells, different in locomotion speed. Only slower tumor cells exhibited protrusions with molecular, morphological, and functional characteristics associated with invadopodia. Each region in the primary tumor exhibited either fast- or slow-locomotion. To understand how the tumor microenvironment controls invadopodium formation and tumor cell locomotion, we systematically analyzed components of the microenvironment previously associated with cell invasion and migration. No single microenvironmental property was able to predict the locations of tumor cell phenotypes in the tumor if used in isolation or combined linearly. To solve this, we utilized the support vector machine (SVM algorithm to classify phenotypes in a nonlinear fashion. This approach identified conditions that promoted either motility phenotype. We then demonstrated that varying one of the conditions may change tumor cell behavior only in a context-dependent manner. In addition, to establish the link between phenotypes and cell fates, we photoconverted and monitored the fate of tumor cells in different microenvironments, finding that only tumor cells in the invadopodium-rich microenvironments degraded extracellular matrix (ECM and disseminated. The number of invadopodia positively correlated with degradation, while the inhibiting metalloproteases eliminated degradation and lung metastasis, consistent with a direct link among invadopodia, ECM degradation, and metastasis. We have detected and characterized two phenotypes of motile tumor cells in vivo, which

  19. Imaging Tumor Necrosis with Ferumoxytol.

    Directory of Open Access Journals (Sweden)

    Maryam Aghighi

    Full Text Available Ultra-small superparamagnetic iron oxide nanoparticles (USPIO are promising contrast agents for magnetic resonance imaging (MRI. USPIO mediated proton relaxation rate enhancement is strongly dependent on compartmentalization of the agent and can vary depending on their intracellular or extracellular location in the tumor microenvironment. We compared the T1- and T2-enhancement pattern of intracellular and extracellular USPIO in mouse models of cancer and pilot data from patients. A better understanding of these MR signal effects will enable non-invasive characterizations of the composition of the tumor microenvironment.Six 4T1 and six MMTV-PyMT mammary tumors were grown in mice and imaged with ferumoxytol-enhanced MRI. R1 relaxation rates were calculated for different tumor types and different tumor areas and compared with histology. The transendothelial leakage rate of ferumoxytol was obtained by our measured relaxivity of ferumoxytol and compared between different tumor types, using a t-test. Additionally, 3 patients with malignant sarcomas were imaged with ferumoxytol-enhanced MRI. T1- and T2-enhancement patterns were compared with histopathology in a descriptive manner as a proof of concept for clinical translation of our observations.4T1 tumors showed central areas of high signal on T1 and low signal on T2 weighted MR images, which corresponded to extracellular nanoparticles in a necrotic core on histopathology. MMTV-PyMT tumors showed little change on T1 but decreased signal on T2 weighted images, which correlated to compartmentalized nanoparticles in tumor associated macrophages. Only 4T1 tumors demonstrated significantly increased R1 relaxation rates of the tumor core compared to the tumor periphery (p<0.001. Transendothelial USPIO leakage was significantly higher for 4T1 tumors (3.4±0.9x10-3 mL/min/100cm3 compared to MMTV-PyMT tumors (1.0±0.9x10-3 mL/min/100 cm3. Likewise, ferumoxytol imaging in patients showed similar findings with

  20. Crescimento tumoral versus estadiamento no carcinoma epidermóide de língua e soalho da boca Tumoral growth versus staging in squamous cell carcinoma of the tongue and floor of the mouth

    Directory of Open Access Journals (Sweden)

    Ali Amar

    2002-08-01

    Full Text Available OBJETIVO: Este estudo tem por objetivo avaliar a relação entre o tamanho do tumor, duração da sintomatologia e a evolução de pacientes com carcinoma epidermóide de língua e soalho bucal. MÉTODO: foram avaliados retrospectivamente 226 pacientes submetidos à ressecção de tumor primário de língua e/ou soalho da boca em combinação com esvaziamento cervical. Foi estimado o crescimento mensal do diâmetro tumoral médio (raiz quadrada da superfície/número de meses de evolução e relacionado com a presença de metástases e recidiva local. A sobrevida livre de doença foi avaliada em relação ao tamanho do tumor e à duração dos sintomas. RESULTADOS: 16% dos tumores T1 e T2 e 11% dos tumores T3 e T4 apresentaram tempo de sintomatologia igual ou inferior a um mês. A mediana de crescimento do diâmetro tumoral foi de 0,81cm/mês. Não houve diferença no crescimento tumoral entre os pacientes pN+ ou pN0; 30 pacientes desenvolveram recidiva local, sendo 15 com crescimento tumoral menor do que 0,82cm/mês e 15 no grupo com crescimento ³ 0,82cm/mês. CONCLUSÕES: A taxa de crescimento tumoral não se relacionou com o intervalo livre de doença nos pacientes que apresentaram recidiva local. Os pacientes com tumores menos extensos e menor duração dos sintomas apresentaram maior sobrevida livre de doença. O tempo de sintomatologia e a estimativa de crescimento tumoral não apresentam valor prognóstico nos carcinomas epidermóides de língua e soalho oral.BACKGROUND: The objective of this study is to evaluate the real impact of tumor size, on symptoms and evolution of patients with squamous cell carcinoma of the tongue and floor of the mouth. METHODS: after 226 neck dissections plus primary resection, were estimated the monthly growing of the medium tumor diameter (square root of surface/number of months and related with metastasis presence and local recurrence. The free disease survival were analysed in relation to tumor syze and

  1. Micetoma pulmonar por Scedosporium sp, reporte de dos casos

    Directory of Open Access Journals (Sweden)

    José G. Somocurcio

    2009-07-01

    Full Text Available Se reporta los dos primeros casos de micetoma pulmonar por Scedosporium sp, en el Perú, tratados quirúrgicamente en el Hospital Nacional Hipólito Unanue. Se practicó resección pulmonar debido a micetoma pulmonar de donde se tomó muestras que fueron enviadas a microbiología y anatomía patológica para cultivo y estudio histopatológico. Se identificó el moho Scedosporium sp en dos pacientes con secuelas cavitarias por tuberculosis, quienes presentaron tos y hemoptisis de dos meses y tres años de evolución, respectivamente. Radiológicamente las cavidades estaban ocupadas por una "bola fúngica". La histopatología indicó presencia de abundantes hifas, indistinguibles de las de Aspergillus sp, mientras que la inmunodifusión para Aspergillus fue negativa.

  2. o caso dos produtos turísticos

    OpenAIRE

    Martins, Carmen Luisa Palhau

    2013-01-01

    Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos de obtenção do grau de Mestre em Ciências da Comunicação, Ramo de Marketing e Publicidade A presente dissertação de mestrado tem como tema A Influência da Internet no Processo de Decisão de Compra do Consumidor, em específico o estudo de caso dos produtos turísticos. O objectivo geral é procurar entender a influência da internet no processo de decisão de compra no caso específico dos produtos turísticos onl...

  3. Tumor triquilemal proliferante

    Directory of Open Access Journals (Sweden)

    Fulin Yu-Tseng

    2015-09-01

    Full Text Available El tumor triquilemal proliferante es una dermatosis tumoral poco frecuente y derivada de la capa externa de la raíz del folículo piloso. Generalmente, es de características benignas, tiende a ser recidivante y se han reportado casos de transformaciones malignas en la bibliografía mundial. El caso trata de una paciente femenina de 59 años, con una neoformación exofítica nodular lobulada de crecimiento lento en piel cabelluda, de 5 años de evolución, con recidivas después de 3 cirugías. No se documentó compromiso óseo ni cerebral en los estudios de gabinete. La biopsia mostró proliferación de nidos de células escamosas en dermis, separados por bandas de tejido fibroso de la epidermis. El abordaje quirúrgico es el tratamiento de elección de esta patología.

  4. NANOROBOTS IN BRAIN TUMOR

    Directory of Open Access Journals (Sweden)

    Sayyed Tarannum, Garje Dattatray H

    2011-02-01

    Full Text Available Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. In the relatively near term, nanomedicine can address many important medical problems by using nanoscale-structured materials and simple nanodevices that can be manufactured today, including the interaction of nanostructured materials with biological systems. The authors predict that technology-assisted medicine and robotics in particular, will have a significant impact over the next few decades. Robots will augment the surgeon’s motor performance, diagnosis capability, and senses with haptics (feel, augmented reality (sight, and ultrasound (sound. Robotic devices have been used in cardiac surgery, urology, fetal surgery, pediatrics, neurosurgery, orthopedics, and many other medical disciplines. In this article, we present the Nanorobot drug delivery to brain tumor, paying special attention to the transformation trends of organizations, and the integration of robots in brain tumor and underscoring potential repercussions which may deserve more attention and further research.

  5. Pericytes limit tumor cell metastasis

    DEFF Research Database (Denmark)

    Xian, Xiaojie; Håkansson, Joakim; Ståhlberg, Anders;

    2006-01-01

    Previously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions...... and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing...... the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied beta cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role...

  6. Primary omental yolk sac tumor.

    Science.gov (United States)

    Lim, Seon Hwa; Kim, Yon Hee; Yim, Ga Won; Nam, Eun Ji; Kim, Young Tae; Kim, Sunghoon

    2013-11-01

    Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules. Explorative laparotomy was performed and then the findings from frozen biopsy of omentum were suggestive of poorly differentiated tumor though whether it was primary or metastatic was uncertain. Thus, staging laparotomy were performed. Histopathology confirmed that the tumor was a yolk sac tumor of omentum origin. Then, 6 cycles of postoperative adjuvant chemotherapy at intervals of 3 weeks were performed using bleomycin, etoposide, and cisplatin regimen. Four-year outpatient follow-up thereafter showed no relapse. PMID:24396822

  7. Vasculogenic mimicry and tumor metastasis.

    Science.gov (United States)

    Zhang, Jingxin; Qiao, Lili; Liang, Ning; Xie, Jian; Luo, Hui; Deng, Guodong; Zhang, Jiandong

    2016-01-01

    Vasculogenic mimicry (VM), a microvascular channel made up of nonendothelial cells, has been accepted as a new model of neovascularization in aggressive tumors, owning to the specific capacity of malignant cells to form vessel-like networks which provide sufficient blood supply for tumor growth. Multiple molecular mechanisms, especially vascular endothelial (VE)-cadherin, erythropoietin-producing hepatocellular receptor A2 (EphA2), phosphatidyl inositol 3-kinase (PI3K), matrix metalloproteinases (MMPs), vascular endothelial growth factor receptor (VEGFR1), and hypoxia inducible factor (HIF)-1a, have been reported to participate in VM formation which is associated with tumor migration and invasion. In addition, hypoxia, cancer stem cells (CSCs) and epithelial-mesenehymal transition (EMT) are regarded as significant factors in VM formation and tumor metastasis. Due to the important effects of VM on tumor progression, a review was carried out in the present study, to synthetically analyze the relationship between VM and tumor metastasis. PMID:27569069

  8. Modeling Tumor Microenvironments In Vitro

    OpenAIRE

    Wu, Mingming; Melody A Swartz

    2014-01-01

    Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels. The emerging fields of tissue engineering and microtechnologies have opened up new possibilities for engineering physiologically relevant and spatially well-defined microenvironments. These in vitro models allow ...

  9. Proton Therapy for Thoracoabdominal Tumors

    Science.gov (United States)

    Sakurai, Hideyuki; Okumura, Toshiyuki; Sugahara, Shinji; Nakayama, Hidetsugu; Tokuuye, Koichi

    In advanced-stage disease of certain thoracoabdominal tumors, proton therapy (PT) with concurrent chemotherapy may be an option to reduce side effects. Several technological developments, including a respiratory gating system and implantation of fiducial markers for image guided radiation therapy (IGRT), are necessary for the treatment in thoracoabdominal tumors. In this chapter, the role of PT for tumors of the lung, the esophagus, and liver are discussed.

  10. Sclerosing Stromal Tumor of Ovary

    OpenAIRE

    Hsiu-Huei Peng; Ting-Chang Chang; Swei Hsueh

    2003-01-01

    Sclerosing stromal tumor of the ovary is a rare ovarian disease with prevalence of 1.5%to 6% of ovarian stromal tumors. We present a 24-year-old woman with irregular menstruationfor 6 months and a self-palpable lower abdominal mass. Enucleation of the left ovariantumor was undertaken. Gross examination showed a soft elastic tumor with a smooth outersurface and diffusely white edematous stroma with scattered yellowish nodular areas on thecut surface. Histologic study showed that the cellular n...

  11. Tumor lysis syndrome developing intraoperatively

    Directory of Open Access Journals (Sweden)

    Ankur Verma

    2011-01-01

    Full Text Available Tumor lysis syndrome is a potentially life threatening condition which is most commonly encountered in patients being treated with chemotherapy. We report a case of spontaneous tumor lysis syndrome that developed intraoperatively in a patient with undiagnosed Burkitt′s lymphoma. Characteristic electrolyte disturbances and white emulsion like urine following laparotomy and tumor handling intraoperatively suggested the diagnosis. This is a rare perioperative complication and the report emphasizes the importance of being vigilant in recognizing the same.

  12. Tumor lysis syndrome developing intraoperatively

    OpenAIRE

    Ankur Verma; Ruchi Mathur; Munish Chauhan; Prashant Ranjan

    2011-01-01

    Tumor lysis syndrome is a potentially life threatening condition which is most commonly encountered in patients being treated with chemotherapy. We report a case of spontaneous tumor lysis syndrome that developed intraoperatively in a patient with undiagnosed Burkitt′s lymphoma. Characteristic electrolyte disturbances and white emulsion like urine following laparotomy and tumor handling intraoperatively suggested the diagnosis. This is a rare perioperative complication and the report emphasiz...

  13. Primary omental yolk sac tumor

    OpenAIRE

    Lim, Seon Hwa; Kim, Yon Hee; Yim, Ga Won; Nam, Eun Ji; Kim, Young Tae; KIM, SUNGHOON

    2013-01-01

    Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules...

  14. Para o estudo da denominação dos conjuntos em português – Aspectos morfo-semânticos dos nomes dos colectivos

    Directory of Open Access Journals (Sweden)

    Margarita Correia

    1999-08-01

    Full Text Available Com este artigo pretendo contribuir para o estudo da denominação dos conjuntos em português europeu. No entanto, ele não pode ser considerado um trabalho exaustivosobre este tema. Dado considerar a estrutura das palavras fundamental para a compreensão do seu significado e uso, prestarei particular atenção a este aspecto dos substantivoscolectivos.Em primeiro lugar, exporei de modo breve o conceito de substantivo colectivo, tendo em especial atenção Cunha & Cintra (1984. Em seguida, descreverei os diferentes tipos de estruturas morfológicas das palavras que podem apresentar acepções colectivas. Finalmente listarei os sufixos envolvidos na construção de substantivos colectivos denominais em português.

  15. TENDÊNCIAS DOS ESTUDOS COM PLANTAS MEDICINAIS NO BRASIL

    OpenAIRE

    Fernanda Melo Carneiro; Maria José Pereira da Silva; Leonardo Luiz Borges; Lorena Carneiro Albernaz,; Joana Darc Pereira Costa

    2014-01-01

    As plantas medicinais são utilizadas pelo homem desde o início da história e atualmente empregadas como recursos na medicina alternativa por grande parte da população mundial. Esse uso deve-se à facilidade de acesso às plantas em relação aos medicamentos alopáticos. O objetivo deste trabalho foi, primariamente, desenvolver uma análise cienciométrica sobre as tendências dos estudos com plantas medicinais no Brasil, investigando se o número de trabalhos cresceu ao longo dos anos. Além disso, f...

  16. O uso dos audiovisuais como recurso didáctico

    OpenAIRE

    Ferreira, Eurico Costa

    2010-01-01

    Tendo em conta que a sociedade actual se rege por uma cultura tecnológica e audiovisual, o aproveitamento dos meios audiovisuais para serem usados como recursos didácticos nas escolas tem uma dupla função. Permite por um lado enquadrar o sistema de ensino nas exigências da nova sociedade, e por outro, criar um ambiente mais próximo do quotidiano dos alunos, tornando a sala de aula num local com uma ambiente mais motivador. No geral, este estudo apresenta os aspectos metodológicos da investiga...

  17. [Tumor of the Parotid Gland].

    Science.gov (United States)

    Pötzl, Teresa; Iselin, Sabine; Husner, Alexander

    2016-05-11

    Salivary gland tumors are a rare, histologically heterogeneous group of tumors which constitute approximately 4–6 % of all head and neck neoplasms. In 2/3 of cases they are benign, especially in the parotid gland. We report about a rare tumor of the parotid gland presenting as an extraskeletal chondroma. Histologically there were multiple S 100 protein-positive nests of chondrocytes. The externally completed cytology suspected a pleomorphic adenoma, nevertheless, the final histopathological findings showed another tumor entity. PMID:27167480

  18. Desmoid tumor within lesser sac

    Directory of Open Access Journals (Sweden)

    Čolović Radoje

    2006-01-01

    Full Text Available Desmoid tumors or fibromatoses comprise a number of benign fibrous proliferative lesions that have local infiltrative growth and tendency to recur after incomplete excision. They never metastasize. The authors present a 31-year old woman who, due to epigastric pain and palpable mass detected on presentation, underwent the excision of firm tumorous mass, 210x140x115mm in diameter, from the lesser sac. Compressing the splenic vein, the tumor caused left-sided portal hypertension which subsided after the mass was removed. The recovery was uneventful. The histological examination verified typical desmoid tumor. Twelve years after surgery, the patient remained symptom-free with no signs of recurrence.

  19. Primary tumors of the patella.

    Science.gov (United States)

    Song, Mingzhi; Zhang, Zhen; Wu, Yuxuan; Ma, Kai; Lu, Ming

    2015-01-01

    The patella is an uncommon location for cancerous occurrence and development. The majority of tumors of the patella are benign, with a significant incidence of giant cell tumors and chondroblastoma. With the development of modern diagnostic technologies, there appear however many other histological types which raise challenges of diagnosis and treatment. In this article, we review the reported histological types of primary patellar tumors. Specifically, epidemiology, symptomatology, imageology, histopathology, and treatment options for these histological lesions will be discussed, respectively. As there is an increasing focus on the diagnosis and the treatment of these lesions, the availability of the integrated information about primary patellar tumors becomes more significant. PMID:25906772

  20. Tumors of the sublingual gland

    DEFF Research Database (Denmark)

    Andreasen, Simon; Bjørndal, K; Agander, T K;

    2016-01-01

    Tumors of the salivary glands are a heterogeneous group of diseases most often originating in the major salivary glands. Only a minor proportion of mainly malignant tumors arise in the sublingual gland. Due to the rarity of sublingual gland tumors (SGTs), little is known about the clinicopathologic...... (ACC). Patient demography was similar to salivary gland tumors in other locations. All fine needle aspiration cytologies (FNACs) interpreted as benign were from ACCs. Metastatic disease was found in 12.5 % of ACCs at diagnosis with one third of all ACC patients having metastases at the end of follow...

  1. Tumors of the lacrimal gland

    DEFF Research Database (Denmark)

    Von Holstein, Sarah Linéa; Rasmussen, Peter Kristian; Heegaard, Steffen

    2016-01-01

    Tumors of the lacrimal gland comprise a wide spectrum, of which the most common demonstrate epithelial and lymphoid differentiation. The diagnosis of lacrimal gland tumors depends primarily on histological evaluation, as do the choice of treatment and prognosis. For some lacrimal gland neoplasms......, such as adenoid cystic carcinoma, the outlook is grave. Optimal treatment for several lacrimal gland tumors is also a matter of controversy. However, recent progress has been made in the molecular and genetic understanding of tumorigenesis for such lesions. This article presents an overview of the histopathology...... of lacrimal gland tumors, together with their epidemiological features, clinical characteristics, and treatment strategies....

  2. [Ovarian germ cell tumors in girls].

    Science.gov (United States)

    Nechushkina, I V; Karseladze, A I

    2015-01-01

    Morphological structure of tumor influences on the clinical course of the disease in children with germ cell tumors. Patients with ovarian dysgerminoma at the time of diagnosis are significantly older than patients with immature teratoma and yolk sac tumor. Immature teratoma and mixed germ cell tumors are significantly larger compared to other germ cell tumors. Yolk sac tumor and embryonal carcinoma are the most common cause of emergency surgical interventions and are accompanied by rupture of tumor capsule. PMID:26087605

  3. Dos realidades: dos maneras de habitar conviven hoy en la ciudad

    Directory of Open Access Journals (Sweden)

    Carmen Faría Larrazábal

    2007-01-01

    Full Text Available Maracaibo, centro de explotación petrolera en Venezuela, desde el siglo XVII organizó su estructura urbana mediante la cuadrícula tradicional española, cuyo tejido presentaba un grano uniforme. La dinámica de crecimiento del siglo XX aportó configuraciones diferentes: las Villas Cerradas, las cuales incorporan paradigmas que dibujan un nuevo orden espacial. El trabajo aborda dos aspectos estrechamente vinculados: por un lado, la solución habitacional ofertada a grupos socioeconómicos de niveles medio y medio-alto, y por otro, cómo estos desarrollos establecen nuevos patrones en el quehacer urbano, y nuevos códigos y significados a la memoria colectiva de sus ciudadanos. Se revisa el statu quo de la acción planificadora y constructiva de la vivienda y se presentan nuevas experiencias realizadas en la década de los 90, las cuales a través de su arquitectura de grandes murallas expresan la autoprotección y el control disciplinario de las relaciones sociales. La investigación utiliza el análisis documental, planimétrico y la observación directa de los fenómenos urbanos como instrumentos de ayuda para dibujar los cambios producidos; lo cual será útil tanto para la comprensión de los procesos y su teorización crítica, como para la enseñanza, el ejercicio de la profesión y la planificación de la ciudad

  4. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

    Directory of Open Access Journals (Sweden)

    Alvear-Sedán Ciro

    2011-09-01

    Full Text Available CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límitesuperior normal. Nunca convulsionó y los síntomas remitieron a los cinco años de edad. Actualmente tiene 14 años y su examenfísico es normal, con talla y peso acorde a la edad. # 2. Producto del segundo embarazo, hermano del anterior, con lactancia hastalos dos años. A los 11 meses de edad presentó cianosis generalizada sin otra sintomatología. Se descartó patología cardiaca. A losdos años presentó cuadro de un mes con distensión abdominal, pérdida de peso, astenia, adinamia, palidez generalizada,hepatomegalia, ascitis, hiperbilirrubinemia mixta con predominio de la directa. Presentó anemia. leucocitos, plaquetas, TP, TPT,proteinograma y glucemia normales. Serologías para hepatitis B negativa. Tamizaje metabólico normal. A los cuatro años presentócrisis tónico-clónica generalizada asociada a vómitos y hepatomegalia homogénea de 5 cm. TAC normal. Edad ósea retardada dedos y medio años, glucemia en ayunas de 31 mg/dL, colesterol, triglicéridos, ácido urico, LDH, AST y FAL elevados. Recibía dieta queincluía maizena antes de acostarse. A los cinco años, biopsia hepática: PAS positivo con cambios compatibles con glicogenosis tipoI. Presentó hematuria persistente, con períodos de hipoglucemia intermitente asintomática. Presentó nefromegalia. A partir de los9 años ha disminuido la hepatomegalia y nefromegalia; tuvo fractura brazo izquierdo con mala consolidación. Actualmente tiene11 años, talla baja de 120 cm

  5. Pediatric Mediastinal Tumors and Tumor-Like Lesions.

    Science.gov (United States)

    Singh, Achint K; Sargar, Kiran; Restrepo, Carlos S

    2016-06-01

    This article reviews the imaging findings of pediatric mediastinal tumors and tumor-like lesions. The classification of the mediastinum is discussed with normal imaging appearance of the thymus in pediatric age group followed by a discussion on multiple mediastinal lesions in different compartments with emphasis on their imaging characteristics.

  6. Tumor estromal gastrointestinal: análise de fatores relacionados ao prognóstico Gastrointesinal stromal tumor: analysis of factors related to the prognostic

    Directory of Open Access Journals (Sweden)

    Rodrigo Panno Basilio de Oliveira

    2007-12-01

    Full Text Available OBJETIVO: estudar os critérios morfológicos e imunoistoquímicos relacionados ao prognóstico dos tumores estromais gastrointestinais. MÉTODOS: o estudo foi retrospectivo de 42 casos de tumor estromal gastrointestinal (GIST. Vinte e cinco casos foram obtidos no arquivo do Serviço de Anatomia Patológica do Hospital Universitário Gaffrée e Guinle e os outros dezessete, do Serviço de Anatomia Patológica do Hospital Universitário Clementino Fraga Filho. RESULTADOS: de acordo com a análise univariada os tumores maiores que 5 cm, com número de mitoses maior que 5/50 CGA, presença de necrose, de alto risco, revelaram significância em relação a redução da sobrevida (p= 0,017, 0,010, 0,001 e 0,016, respectivamente. Os outros fatores analisados (subtipo histológico, topografia e imunofenótipo não mostraram significância. CONCLUSÃO: os resultados confirmam a utilidade do grau de risco, do tamanho tumoral, do índice mitótico e da necrose como fatores preditores do comportamento biológico dos tumores estromais gastrointestinais.OBJECTIVE: study the morphologic criteria and immunohistochemical related with the prognostic of the gastrointestinal stromal tumors. METHODS: the study was retrospective of 42 cases of gastrointestinal stromal tumor (GIST. Twenty-five cases were obtained in the file of the Services of Pathological Anatomy of the Hospital Gaffrée and Guinle and the other 17 of Pathological Anatomy of the Hospital Clementino Fraga Filho. RESULTS: in agreement with the univaried analysis, the tumors largest than 5 cm, with mitoses number greater than 5/50 CGA, presence of necrosis, high risk, revealed significance with regarding the reduction of the survival (P = 0.017, 0.01, 0.001 and 0.016, respectively. The other analyzed factors (histological subtype, topography and imunophenotype they didn't show significance. CONCLUSION: the results confirm the usefulness of the risk degree, the tumorous size, the mitotic index and the

  7. Intraoperative tumor lysis syndrome in a child with Wilms' tumor.

    Science.gov (United States)

    Dhar, Mridul; Prakash, Shashi; Pandey, Vaibhav; Pai, Vishal Krishna

    2016-01-01

    Tumor lysis syndrome in an onco-metabolic emergency resulting from massive lysis of rapidly proliferating malignant cells seen commonly in patients with hematological malignancies such as acute lymphocytic leukemia and Burkitt's lymphoma and is quite rare in solid tumors. Spontaneous development of tumor lysis has been described among other trigger factors such as corticosteroid therapy, anesthesia, tumor manipulation during surgery and pyrexia. We describe such a case in a 5-year-old boy posted for excision and staging of a massive Wilms' tumor who developed a hyperkalemic cardiac arrest during the procedure and its subsequent intraoperative and postoperative management. Intraoperative cardiac arrest is a stressful situation for both the anesthesiologist and the surgeon, more so when it involves a child. The aim of this report is to make the anesthesiologist aware of the possibility and occurrence of such a phenomenon in children and be adequately prepared for such an emergency. PMID:26957712

  8. Hepatic tumor volumetry

    International Nuclear Information System (INIS)

    Accurate CT quantification of hepatic tumor volume in sequential CT studies of oncology patients could provide a reliable morphologic marker of disease response to chemotherapy. At present, estimates of morphologic response are based on number and size of individual lesions. In this paper three-dimensional (3D) technique is presented. A filtering program is applied to all two-dimensional (2D) sections to increase signal-to-noise ratio while maintaining boundary delineation. A CT number histogram of normal and abnormal intrahepatic tissue derived from a representative 2D section is applied in sequence to contiguous 2D sections in 3D space. A user graphics tool is available to correct for false delineation

  9. Cystic tumors of Pancreas

    International Nuclear Information System (INIS)

    Case material consists of five patients, four of them corresponding to cystic tumors of pancreas and one to a pseudocyst which, as literature tells us, is often difficult to differentiate from the former.There is a description of main clinical and image aspects and the conduct applied there to. This subject is in full process of development and new pathology grading is applied although the last word has yet to be said. It is very difficult to reach exact diagnosis in the pre and in the intra operative stage. As they tend to be malignant, surgical resection is advised, however without discarding enucleation.Whenever they are malignant prognosis in general is better than in the case of solid pancreatic cancer

  10. Cystic tumors of Pancreas

    International Nuclear Information System (INIS)

    Case material consist of five patients, four of them corresponding to cystic tumors of Pancreas and one to pseudocyst which, as literature tells us, is often difficult to differentiate from the former.There is a description of main clinical and image aspects and the conduct applied thereto. This subject is in full process of development and a new pathology grading is applied although the last word has yet to be said. It is very difficult to reach exact diagnosis in the pre-and in the intra-operative stage.As they tend to be malignant, surgical resection is advised, however without discarding enucleation.Whenever they are malignant prognosis in general is better than in the case of solid pancreatic cancers

  11. Familial germ cell tumor

    Directory of Open Access Journals (Sweden)

    Sanju Cyriac

    2012-01-01

    Full Text Available Familial testicular germ cell tumors are well known in literature. Only few cases are reported where both brother and sister of the same family suffered from germ cell malignancies. We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presence of germ cell malignancies in the siblings of different sex in the same family points toward a genetic susceptibility. Literature review revealed only six similar cases. A discussion regarding the rare occurrence of familial germ cell malignancies with the affected family members may be worthwhile.

  12. Cathepsins mediate tumor metastasis

    Institute of Scientific and Technical Information of China (English)

    Gong-Jun; Tan; Zheng-Ke; Peng; Jin-Ping; Lu; Fa-Qing; Tang

    2013-01-01

    Cathepsins are highly expressed in various human cancers, associated with tumor metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family members. As a group of lysosomal proteinases or endopeptidases, each member has a different function, playing different roles in distinct tumorigenic processes such as proliferation, angiogenesis, metastasis, and invasion. Cathepsins belong to a diverse number of enzyme subtypes, including cysteine proteases, serine proteases and aspartic proteases. The contribution of cathepsins to invasion in human cancers is well documented, although the precise mechanisms by which cathepsins exert their effects are still not clear. In the present review, the role of cathepsin family members in cancer is discussed.

  13. Gynecological tumors; Gynaekologische Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin; Nitzsche, E.U. [Freiburg Univ. (Germany). Abt. Nuklearmedizin

    2000-09-01

    Early diagnosis and accurate staging of gynecological tumors based on noninvasive imaging remains a challenge. US, CT and MRI lack sensitivity and specificity for diagnosis and staging of primary disease, residual mass and recurrent disease. FDG-PET may add some important diagnostic information, but currently available results from initial studies indicate that it will not replace other staging tools for specific questions to be answered during work-up. (orig.) [German] Fruehdiagnose und korrekte nichtinvasive bildgebende Ausbreitungsdiagnostik von gynaekologischen Tumorerkrankungen sind vorerst weiterhin eine Illusion. US, CT und MRI erreichen bisher keine akzeptable Sensitivitaet und Spezifitaet in der Primaertumordiagnostik, Tumorresiduendiagnostik und Tumorrezidivdiagnostik. Die FDG-PET wird moeglicherweise wichtige Informationen bezueglich Lymphknotenbefall und Fernmetastasierung sowie Rezidivdetektion beitragen koennen, initiale Studienergebnisse zeigen jedoch, dass sie etablierte Staginguntersuchungen gegenwaertig nicht ersetzen kann. (orig.)

  14. Use of different simulators to quality evaluation of image quality in digital mammography; Utilizacao de diferentes simuladores na avaliacao da qualidade da imagem em mamografia digital

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Leslie S.; Coutinho, Celia M.C., E-mail: leslie@ird.gov.br, E-mail: celia@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Magalhaes, Luis A.G.; Almeida, Carlos Eduardo de, E-mail: luisalexandregm@hotmail.com, E-mail: cea71@yahoo.com.br [Universidade do Estado do Rio de Janeiro (LCR/UERJ), Rio de Janeiro, RJ (Brazil). Laboratorio de Ciencias Radiologicas

    2013-11-01

    In this study, the digital images were acquired with different exposure simulators to evaluate the quality of the image, noting the tumor mass detection, microcalcification fiber and representing regions of interest during mammography. The technical parameters of exposure depends on the thickness and composition of the breast, thus affecting the dose and image quality. The simulators were used: ACR, SBP 1054, BREAST PHANTOM CIRS and for evaluation of image quality, as well as measures kerma incident on the entrance surface (Ki) and calculating the mean glandular dose (MGD)

  15. In vivo and in vitro evaluation of dota-lanreotide radiolabelled with gallium-67; Avaliacao in vivo e in vitro do dota-lanreotideo radiomarcado com galio-67

    Energy Technology Data Exchange (ETDEWEB)

    Aldegheri, Eliane Bernardes

    2005-07-01

    One of the refinements of modern Nuclear Medicine is the capacity of providing dynamic and kinetics images of the administered radiopharmaceutical, reproducing its transport mechanism, action sites, receptor binding and excretion route. With the continues technological advances new radiopharmaceuticals have been developed in order to express higher specificity and with higher characters of affinity between receptor/complex. One radiopharmaceutical is formed by a reagent or bio molecule that has in its structure a radioisotope, that has the objectives of carrying it to the organs of affinity or to benign or malign tumoral process. Somatostatin inhibits the growing and proliferation of several tumoral cells. Somatostatin analogs bind to somatostatic receptors that are expressed in different kind of neoplasia DOTA-LANREOTIDE (DOTALAN) is an octapeptide analog to somatostatin. The interest of labeling the bio conjugate with gallium-67 in Nuclear Medicine comes from its physical, chemical and biological properties. Besides its gamma radiation, useful in the diagnosis of inflammation and infection foci, {sup 67}Ga emits Auger electrons (0.1 - 8 keV) and conversion electrons (80 - 90 keV), making it attractive to internal radiotherapy if the vectors used to lead the radionuclide to the tumoral cell are internalized. The objective of this work was to develop a methodology of labelling DOTA-LANREOTIDE with {sup 67}Ga, optimizing the labelling variables and its quality control. The novelty aspect was the comparison between labeling with national and imported {sup 67}Ga, in its original and purified forms. The purification of {sup 67}Ga was essential to reach yields higher than 90%. The radiolabelled bio conjugate peptides must be free of metallic contaminants that could compete in the labeling process. The following procedure was established after studying the labeling parameters: mass of peptide of 10 {mu}g (6nmol), pH5, final reaction volume of 170 {mu}L of the labelled

  16. O reconhecimento dos direitos dos povos indígenas sob a perspectiva internacional e a brasileira

    OpenAIRE

    MARIANA YOKOYA SIMONI

    2009-01-01

    O objetivo da presente análise é descrever,

    brevemente, o surgimento e a evolução do tema

    dos direitos dos povos indígenas na agenda de

    organizações internacionais – como a Organização

    Internacional do Tra...

  17. Análise dos modelos de “governance” e práticas dos portos Portugueses

    OpenAIRE

    Pereira , Ana Filipa Correia

    2014-01-01

    Portugal é um país rico em potencial económico marítimo, para o desenvolvimento de quaisquer atividades que tenham no mar a sua base. Atualmente, o transporte marítimo está a deslocar-se para outras regiões do mundo, nomeadamente a bacia do pacífico, sendo estas consideradas atualmente como as mais competitivas. Assim, o estudo dos modelos e práticas destas regiões poderão gerar um contributo para a inovação dos portos portugueses, tratando-se de um desafio para o setor portuá...

  18. Influência de Agaricus blazei Murrill sobre o tumor sólido de Ehrlich e linfonodos poplíteos de camundongos Influence of Agaricus blazei Murrill in solid Ehrlich tumor and popliteal lymph nodes in mice

    Directory of Open Access Journals (Sweden)

    D. Verçosa Junior

    2007-02-01

    Full Text Available Estudou-se a influência do tratamento diário com filtrado aquoso de Agaricus blazei Murrill (ABM (25mg/ml, via oral, por 17 e 57 dias, em camundongos inoculados com tumor sólido de Ehrlich (TSE por meio da curva de crescimento tumoral, do peso relativo do tumor, da contagem de regiões organizadoras de nucléolos (AgNORs e dos padrões histológicos das massas tumorais e linfonodos poplíteos. Os animais que ingeriram o extrato aquoso do ABM por 57 dias apresentaram menor (P0,05 entre os animais tratados e não tratados.The influence of daily administration of Agaricus blazei Murrill (ABM aqueous solution (25mg/ml during 17 and 57 days in mice bearing solid Ehrlich tumor was studied. Tumoral growth, tumoral and spleenic relative weights, nucleoly organization regions AgNORs values and tumor and popliteal lymph nodes histopathology were daily evaluated. The animals that received ABM during 57 days showed lower values (P0.05 between treated and non-treated animals. No difference in microscopic evaluation of the tumors in treated and non-treated animals was seen and metastasis in popliteal nodes of the tumor occurred in all the animals.

  19. Stealth-MITM DoS Attacks on Secure Channels

    CERN Document Server

    Herzberg, Amir

    2009-01-01

    We define stealth Man-in-the-Middle adversaries, and analyse their ability to launch denial and degradation of service (DoS) attacks on secure channels. We show realistic attacks, disrupting TCP communication over secure VPNs using IPsec. We present: First amplifying DoS attack on IPsec, when deployed without anti-replay window. First amplifying attack on IPsec, when deployed with a `small' anti-replay window, and analysis of `sufficient' window size. First amplifying attack on IPsec, when deployed with `sufficient' window size. This attack (as the previous) is realistic: attacker needs only to duplicate and speed-up few packets. We also suggest a solution designed to prevent the presented attacks, and to provide secure channel immune to degradation and other DoS attacks. Our solution involves changes (only) to the two gateway machines running IPsec. In addition to their practical importance, our results also raise the challenge of formally defining secure channels immune to DoS and degradation attacks, and p...

  20. DOS VALORES INDIVIDUALISTAS AOS CAMINHOS DE SUPERAÇÃO

    Directory of Open Access Journals (Sweden)

    Róber Iturriet Avila

    2014-08-01

    Full Text Available 800x600 Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Este artigo se propõe averiguar as fontes dos valores individualistas na sociedade contemporânea. Para tanto, eles serão analisados por dois fatos geradores; i pela influência dos intelectuais nestes valores e; ii pelo condicionamento dos homens diante do arranjo econômico. Pauta ainda este trabalho as maneiras de mitigar tais valores, no tempo em que se gestam valores coletivistas. Este papel é analisado a partir de dois prismas i pelo papel dos intelectuais na formação de valores; ii a partir do sistema educacional que os potencialize. Assim, este trabalho versa, adicionalmente, sobre como a educação formal pode ter um papel importante na transformação cultural de uma sociedade.

  1. Dos nuevas especies de Acalypha L. (Euphorbiaceae de Venezuela

    Directory of Open Access Journals (Sweden)

    Cardiel, José María

    1999-06-01

    Full Text Available Two new species of the genus Acalypha L. are described and illustrated, A. longipetiolata and A. venezuelica. Comments on the differences between these and related species are included.Se describen e ilustran dos nuevas especies del género Acalypha L., A. longipetiolata y A. venezuelica, descritas sobre material venezolano; se comentan las principales diferencias con las especies afines

  2. O número dos nomes em português

    Directory of Open Access Journals (Sweden)

    Clóvis Barleta de Morais

    2001-02-01

    Full Text Available

    Sistematização do estudo do número dos substantivos e adjetivos em português com base na pronúncia (fonologia, e não na ortografia, como se faz geralmente. Apresentação de listas de palavras que constituem exceções.

  3. Empreededorismo social: caso da 'cidade dos meninos' Belo Horizonte - Brasil

    Directory of Open Access Journals (Sweden)

    Walter Marinho de Oliveira

    2010-09-01

    Full Text Available A Cidade dos Meninos de São Vicente de Paulo, é uma das mais ousadas e completas abordagens no enfrentamento do problema dos menores de rua no Brasil. Este artigo, descreve a experiência da “Cidade dos Meninos” e de seu idealizador, apoiando-se em teorias recentes sobre empreendedorismo social. Atenção especial é dada à definição de empreendedor social catalítico (WADDOCK; POST, 1991, relacionando a atuação da liderança da Cidade dos Meninos a esse perfil. Uma das possíveis conclusões é que, em países em desenvolvimento como o Brasil, o empreendedor social catalítico não pode exercer apenas a função de criador e implementador de políticas, face a dimensão da carência e do problema com o qual ele se confronta, envolvendo-se então na ação direta

  4. Emprego dos gangliosidos do cortex cerebral nas neuropatias perifericas

    Directory of Open Access Journals (Sweden)

    James Pitagoras De Mattos

    1981-12-01

    Full Text Available Os autores registram a experiência pessoal com o emprego de gangliosídios do cortex cerebral nas neuropatias periféricas. O ensaio clínico e eletromiográfico revelou-se eficaz em 30 dos 40 casos tratados. Enfatizam os melhores resultados em casos de paralisias faciais periféricas.

  5. Tumor do VIII nervo com apresentação incomum An uncommon presentation of an VIII nerve tumor

    Directory of Open Access Journals (Sweden)

    Rubem Cruz Swensson

    2008-08-01

    Full Text Available Os Schwannomas vestibulares são responsáveis por 80 a 90% dos tumores do ângulo ponto-cerebelar. A atual incidência é estimada em 0,8% a 2,5% da população mundial. A hipoacusia unilateral e progressiva é o sintoma mais precoce e freqüente, sendo o tinido a segunda queixa mais comum. Estudos demonstram que apenas 5% dos pacientes com schwannoma vestibular têm exames audiométricos normais. No caso em foco é relatado hipoestesia da hemiface com diminuição do reflexo córneo palpebral ipsilateral, hipoestesia da porção póstero-superior do pavilhão auditivo (sinal de Hitzelberger positivo, diminuição do lacrimejamento, Romberg sensibilizado positivo. Observava-se discreto desvio da rima labial para a esquerda, não apresentando outras alterações nos demais pares cranianos. À acumetria, não havia alteração da sensibilidade auditiva em ambas as vias aéreas.Vestibular Shwannomas are responsible for 80-90% of the cerebelar-pontine angle tumors and their incidence is of 0.8 to 20.5% of all tumors. Unilateral and progressive hearing loss is the most frequent and premature symptom, and tinnitus is the second most common complaint. Only 5% of the patients have normal audiograms. In this case the patient complained of ipsilateral facial numbness and weak blink, posterior pinna hypoesthesia (Hitzelberger +, tear reduction and positive Romberg test. He also had mouth twisting but no other involvement of other cranial nerves. Hearing acuity was normal.

  6. Imaging probe for tumor malignancy

    Science.gov (United States)

    Tanaka, Shotaro; Kizaka-Kondoh, Shinae; Hiraoka, Hasahiro

    2009-02-01

    Solid tumors possess unique microenvironments that are exposed to chronic hypoxic conditions ("tumor hypoxia"). Although more than half a century has passed since it was suggested that tumor hypoxia correlated with poor treatment outcomes and contributed to cancer recurrence, a fundamental solution to this problem has yet to be found. Hypoxia-inducible factor (HIF-1) is the main transcription factor that regulates the cellular response to hypoxia. It induces various genes whose functions are strongly associated with malignant alteration of the entire tumor. The cellular changes induced by HIF-1 are extremely important targets of cancer therapy, particularly in therapy against refractory cancers. Imaging of the HIF-1-active microenvironment is therefore important for cancer therapy. To image HIF-1activity in vivo, we developed a PTD-ODD fusion protein, POHA, which was uniquely labeled with near-infrared fluorescent dye at the C-terminal. POHA has two functional domains: protein transduction domain (PTD) and VHL-mediated protein destruction motif in oxygen-dependent degradation (ODD) domain of the alpha subunit of HIF-1 (HIF-1α). It can therefore be delivered to the entire body and remain stabilized in the HIF-1-active cells. When it was intravenously injected into tumor-bearing mice, a tumor-specific fluorescence signal was detected in the tumor 6 h after the injection. These results suggest that POHA can be used an imaging probe for tumor malignancy.

  7. Management of salivary gland tumors

    NARCIS (Netherlands)

    Andry, Guy; Hamoir, Marc; Locati, Laura D.; Licitra, Lisa; Langendijk, Johannes A.

    2012-01-01

    Surgery after proper imaging (MRI or CT scan) is the main stay of treatment for salivary gland tumors. Although excision margins should be >= 5 mm for malignant tumors in cases of parotid gland carcinoma, the facial nerve should be preserved whenever it is not infiltrated. Adjuvant external radiatio

  8. Surgical strategies in endocrine tumors

    NARCIS (Netherlands)

    Schreinemakers, J.M.J.

    2010-01-01

    Endocrine surgery has become more custom-made throughout the years. Endocrine tumors can be sporadic or develop as part of familial syndromes. Several familial syndromes are known to cause endocrine tumors. The most common are multiple endocrine neoplasia (MEN) syndromes type 1, 2A and 2B. This thes

  9. Living with a Brain Tumor

    Science.gov (United States)

    ... when you have been diagnosed with a brain tumor diagnosis. Dealing with changes to your appearance – such as losing your hair or losing weight is difficult for most of us. Keep in mind that your life is not so much ... with a brain tumor may mean rethinking your work and professional goals, ...

  10. [Local treatment of liver tumors

    DEFF Research Database (Denmark)

    Pless, T.K.; Skjoldbye, Bjørn Ole

    2008-01-01

    Local treatment of non-resectable liver tumors is common. This brief review describes the local treatment techniques used in Denmark. The techniques are evaluated according to the evidence in literature. The primary local treatment is Radiofrequency Ablation of both primary liver tumors and liver...

  11. Brain Tumor Epidemiology Consortium (BTEC)

    Science.gov (United States)

    The Brain Tumor Epidemiology Consortium is an open scientific forum organized to foster the development of multi-center, international and inter-disciplinary collaborations that will lead to a better understanding of the etiology, outcomes, and prevention of brain tumors.

  12. Benign mixed tumor of the lacrimal sac

    Directory of Open Access Journals (Sweden)

    Jong-Suk Lee

    2015-01-01

    Full Text Available Neoplasms of the lacrimal drainage system are uncommon, but potentially life-threatening and are often difficult to diagnose. Among primary lacrimal sac tumors, benign mixed tumors are extremely rare. Histologically, benign mixed tumors have been classified as a type of benign epithelial tumor. Here we report a case of benign mixed tumor of the lacrimal sac.

  13. Tumor mediastinal de células germinativas e sua relação com anormalidades hematológicas Mediastinal germ cell tumors and its relationship with hematological disorders

    Directory of Open Access Journals (Sweden)

    Carlos R. Medeiros

    2000-08-01

    Full Text Available Tumores mediastinais de células germinativas são raros (2% a 10% dos tumores germinativos e cerca de 100 casos são diagnosticados anualmente. Apresentam a particularidade de em um terço dos casos estarem associados a doenças hematológicas, com freqüência malignas. Duas teorias tentam explicar a origem desta associação. Na primeira, anormalidades da célula totipotencial comum a ambas as doenças seriam as responsáveis. O achado da alteração isocromossômica do cromossoma 12, tanto nos tumores mediastinais de células germinativas quanto nas células hematopoéticas componentes das anormalidades hematológicas, sugere a mesma origem para ambas as células primordiais. Na segunda, o efeito de agentes quimioterápicos usados para tratamento dos tumores mediastinais de células germinativas (principalmente o etoposide sobre uma célula tronco hematopoética instável poderia induzir ao aparecimento da neoplasia hematológica, geralmente associada a anormalidades do cromossoma 11. Habitualmente, tanto os tumores mediastinais de células germinativas quanto a anormalidade hematológica têm comportamento agressivo e são de difícil tratamento. Novas abordagens podem ser exploradas no estadiamento e tratamento destas situações.Mediastinal germ cell tumors are uncommon (2 to 10% of germ cell tumors, and around 100 new cases are diagnosed annually. Their relationship with hematological disorders is an unique aspect of these tumors. The hematological disorder may be part of the natural history of the germ cell tumor, both sharing the same abnormal totipotential stem cell. The two most common hematological neoplasms seen in this syndrome are acute leukemia and malignant histiocytosis. The finding of the marker chromosome isochromosome i(12p in the mediastinal germ cell tumors and associated malignant disorder is a suggestion that both tumors may arise from a common progenitor cell. A more remote possibility is that the hematological

  14. Estudo dos elementos celulares na medula humana dos adultos I. linhagem plasmocitária

    Directory of Open Access Journals (Sweden)

    M. R. Q de Kastner

    1972-01-01

    Full Text Available Examinando o conjunto dos resultados obtidos nesta pesquisa e os dados pela literatura, observamos que o aumento numérico de células plasmáticas na medula óssea é um fenômeno relativamente freqüente. Todo hematologista habituado pode facilmente fazer o diagnóstico do estado da célula plasmocitária pela sua morfologia, seu tamanho e sua coloração. Nos quadros mais proeminentes de predominância de células de linhagem plasmocitária, os exames hematológicos e clínicos aliados ao mielograma, auxiliarão no diagnóstico do plasmocitoma. A nosso ver, os sinais (qualitativos, distintivos, de natureza citológica, que aparecem nos mielogramas no caso de plasmocitoma são: a Pleomorfismo e dismorfismo na célula plasmática; b "Rouleaux" de hemácias, já visível no hemograma; c Aumento das dimensões de alguns metamielócitos e bastonetes, acompanhados geralmente de atipias nucleares. Atipias e plurissegmentação nos segmentados; d No setor plaquetogenético aparecem plaquetas grandes e certo grau de perturbação nos megacarióticos, traduzido ás vezes pela presença de núcleos nus.Two hundred fifty bone marrow specimens, including twenty seven from hematologically normal patients, were examined hitologically. The Wright's and Brachet's stains were used. Plasma cells were rarely seen in the peripheral blood and bone marrow of normal individuals, but they were prominent constituents in some pathological states. A number significantly increased of plasma cells or mieloma cells were usually recognized in bone marrow from patients with plasmacytoma. These cells ranged from a very anaplastic immature form to closely resembling plasma cell. Even in the same patient, considerable pleomorphism often occured, and variation in cell size, number of nuclei and degree of nuclear immaturity were common. Although the results report certain observations regarding to the other cell series in patients with plasmacytoma. The most suggestive evidences

  15. Dinâmica dos micronutrientes em cafeeiros enxertados

    Directory of Open Access Journals (Sweden)

    André Dominghetti Ferreira

    2013-04-01

    Full Text Available As respostas à disponibilidade dos nutrientes variam entre espécies distintas dentro de um mesmo gênero, por causa, principalmente, das exigências nutricionais variáveis, capacidade de absorção, translocação e utilização dos nutrientes. O objetivo deste trabalho foi avaliar a eficiência de absorção, translocação e uso dos micronutrientes por diferentes cultivares de Coffea arabica L., enxertados em Apoatã IAC 2258 (Coffea canephora. O experimento foi instalado em casa de vegetação, utilizando-se o método de cultivo em solução nutritiva. Foi utilizado um fatorial 7 x 3 + 2, sendo sete cultivares de Coffea arabica L. (Palma II, Catucaí 2 SL, Oeiras MG 6851, Obatã IAC 1669-20, Acauã, Topázio MG 1190 e Paraíso MG H 419-1, três tipos de mudas (pé franco, autoenxertada e enxertada sobre o cultivar Apoatã IAC 2258 e duas testemunhas (Apoatã autoenxertado e Apoatã pé franco. O porta-enxerto utilizado influenciou negativamente na absorção de boro, ferro e manganês. A translocação dos micronutrientes boro e cobre obteve maiores índices nas mudas enxertadas. O cultivar Palma II, quando enxertado, apresentou o maior índice de utilização dos nutrientes, mostrando-se passível de ser enxertado. O porta-enxerto utilizado mostrou-se apto para a enxertia, por não sofrer influência negativa, tanto pela enxertia, quanto pelos cultivares utilizados.

  16. [Radiological evaluation of congenital tumors].

    Science.gov (United States)

    Aguado del Hoyo, A; Ruiz Martín, Y; Lancharro Zapata, Á; Marín Rodríguez, C; Gordillo Gutiérrez, I

    2015-01-01

    In this article, we consider tumors that are diagnosed during pregnancy or in the first three months of life. This is a heterogeneous group of neoplasms with special biological and epidemiological characteristics that differentiate them from tumors arising in children or adults. In the last two decades, the prenatal detection of congenital tumors has increased due to the generalized use of prenatal sonographic screening. Advances in imaging techniques, especially in fetal magnetic resonance imaging, have enabled improvements in the diagnosis, follow-up, clinical management, and perinatal treatment of these tumors. This image-based review of the most common congenital tumors describes their histologic types, locations, and characteristics on the different imaging techniques used.

  17. Metabolic exchanges within tumor microenvironment.

    Science.gov (United States)

    Chiarugi, Paola; Cirri, Paolo

    2016-09-28

    Tumor progression toward malignancy often requires a metabolic rewiring of cancer cells to meet changes in metabolic demand to forefront nutrient and oxygen withdrawal, together with strong anabolic requests to match high proliferation rate. Tumor microenvironment highly contributes to metabolic rewiring of cancer cells, fostering complete nutrient exploitation, favoring OXPHOS of lipids and glutamine at the expense of glycolysis and enhancing exchanges via extracellular microvesicles or exosomes of proteins, lipids and small RNAs among tumor and stromal cells. Noteworthy, the same molecular drivers of metabolic reprogramming within tumor and stroma are also able to elicit motility, survival and self-renewal on cancer cells, thereby sustaining successful escaping strategies to circumvent the hostile hypoxic, acidic and inflammatory environment. This review highlights the emerging role of nutrients and vesicle-mediated exchanges among tumor and stromal cells, defining their molecular pathways and offering new perspectives to develop treatments targeting this complex metabolic rewiring. PMID:26546872

  18. Notch Signaling and Brain Tumors

    DEFF Research Database (Denmark)

    Stockhausen, Marie; Kristoffersen, Karina; Poulsen, Hans Skovgaard

    2011-01-01

    Human brain tumors are a heterogenous group of neoplasms occurring inside the cranium and the central spinal cord. In adults and children, astrocytic glioma and medulloblastoma are the most common subtypes of primary brain tumors. These tumor types are thought to arise from cells in which Notch...... signaling plays a fundamental role during development. Recent findings have shown that Notch signaling is dysregulated, and contributes to the malignant potential of these tumors. Growing evidence point towards an important role for cancer stem cells in the initiation and maintenance of glioma...... and medulloblastoma. In this chapter we will cover the present findings of Notch signaling in human glioma and medulloblastoma and try to create an overall picture of its relevance in the pathogenesis of these tumors....

  19. [Radiotherapy of benign intracranial tumors].

    Science.gov (United States)

    Delannes, M; Latorzeff, I; Chand, M E; Huchet, A; Dupin, C; Colin, P

    2016-09-01

    Most of the benign intracranial tumors are meningiomas, vestibular schwannomas, pituitary adenomas, craniopharyngiomas, and glomus tumors. Some of them grow very slowly, and can be observed without specific treatment, especially if they are asymptomatic. Symptomatic or growing tumors are treated by surgery, which is the reference treatment. When surgery is not possible, due to the location of the lesion, or general conditions, radiotherapy can be applied, as it is if there is a postoperative growing residual tumor, or a local relapse. Indications have to be discussed in polydisciplinary meetings, with precise evaluation of the benefit and risks of the treatments. The techniques to be used are the most modern ones, as multimodal imaging and image-guided radiation therapy. Stereotactic treatments, using fractionated or single doses depending on the size or the location of the tumors, are commonly realized, to avoid as much a possible the occurrence of late side effects. PMID:27523417

  20. Tumor de colisión periampular Collision tumor of the ampulla of Vater: Carcinoid and adenocarcinoma

    Directory of Open Access Journals (Sweden)

    J. Ferrando Marco

    2007-04-01

    Full Text Available Presentamos un caso de tumor de colisión periampular en el que coexisten un tumor carcinoide de pared duodenal y un adenocarcinoma de cabeza de páncreas. El paciente era un varón de 64 años con historia reciente de diarreas al que se diagnosticó una ictericia obstructiva. Histopatológicamente el tumor resecado mostraba dos neoplasias independientes. Una de ellas constituida por cordones sólidos de células neuroendocrinas que afectaba pared duodenal. La otra está formada por un adenocarcinoma bien diferenciado procedente del páncreas. Ambas neoplasias fueron confirmadas inmunohistoquímicamente. Según la literatura anglosajona revisada tan sólo hemos encontrado seis casos de esta rara coexistencia neoplásica.We report the case of a periampullary collision tumor, in which a duodenal-wall carcinoid and an adenocarcinoma of the head of the pancreas coexisted. We describe the case of a 64-year-old man with a recent history of diarrhea, who was diagnosed with obstructive jaundice. A duodeno-pancreatectomy was performed, and the specimen showed two independent neoplasms in the histopathologic study. Solid cords and nests of neuroendocrine cells in the duodenal wall formed the carcinoid tumor, whereas the other neoplasm was made up of a well-differentiated adenocarcinoma of the pancreas. Both were confirmed by immunohistochemical analysis. According to the literature reviewed, this is the sixth reported case of this rare neoplastic association.

  1. Evaluation of environmental impacts in the mining of solid fossil fuels; Avaliacao de impactos ambientais na mineracao de combustiveis fosseis solidos

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Gilda Carneiro

    1989-07-01

    This study evaluates the environmental problems caused by the mining works of coal, peat and oil schists; also it evaluates the kind of treatment used by the mining companies against water, air and ground pollution, as well as the necessary control according to the mine activities and the affected environment. the studied areas are situated at brasilian states of Santa Catarina (Criciuma, Urussanga and Sideropolis), Rio Grande do Sul (Charqueada, Bage, Cachoeira do Sul, Butia and Arroio dos Ratos), Parana (Figueira and Sao Mateus do Sul), and Sao Paulo (Iguape and Sao Jose dos Campos). This study was done through a direct inquiry, by sending questionnaire to fifteen coal mining companies, three of peat ones and one of oil schists one. besides it was done a compilation of federal and state laws concerning to the environment and on the rights and duties of the mining companies. The information brought up in this way were compiled into a data bank, which allowed and sample surveys of environmental condition in the different industries and further it enabled a comparison between the real facts and the bibliography suggestions about adequate monitoring of the air, waters and ground, during mining activities. this analysis showed that the environment problems, created by the three former kind of mining works, are under control through projects of environment restoring and monitoring in phase of implantation and that these projects are restricted to that less expensive and easier to construct (holding back in pools or reservoirs, pouring in pits and aspersion). It was not notices a significant monitoring of parameters considered to be critical to the environment (metals, cyanides, sulphide and general bacteria). Almost all the companies have not yet exact data about the efficiency of each kind of environmental treatment because it is new ones and are just in follow-up and consequently they have not yet parameters to change the adequate the steps of the treatment, because

  2. IMRT in hypopharyngeal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Studer, G.; Luetolf, U.M.; Davis, J.B.; Glanzmann, C. [Dept. of Radiation Oncology, Univ. Hospital, Zurich (Switzerland)

    2006-06-15

    Background and purpose: intensity-modulated radiation therapy (IMRT) data on hypopharyngeal cancer (HC) are scant. In this study, the authors report on early results in an own HC patient cohort treated with IMRT. A more favorable outcome as compared to historical data on conventional radiation techniques was expected. Patients and methods: 29 consecutive HC patients were treated with simultaneous integrated boost (SIB) IMRT between 01/2002 and 07/2005 (mean follow-up 16 months, range 4-44 months). Doses of 60-71 Gy with 2.0-2.2 Gy/fraction were applied. 26/29 patients were definitively irradiated, 86% received simultaneous cisplatin-based chemotherapy. 60% presented with locally advanced disease (T3/4 Nx, Tx N2c/3). Mean primary tumor volume measured 36.2 cm{sup 3} (4-170 cm{sup 3}), mean nodal volume 16.6 cm{sup 3} (0-97 cm{sup 3}). Results: 2-year actuarial local, nodal, distant control, and overall disease-free survival were 90%, 93%, 93%, and 90%, respectively. In 2/4 patients with persistent disease (nodal in one, primary in three), salvage surgery was performed. The mean dose to the spinal cord (extension of > 5-15 mm) was 26 Gy (12-38 Gy); the mean maximum (point) dose was 44.4 Gy (26-58.9 Gy). One grade (G) 3 dysphagia and two G4 reactions (laryngeal fibrosis, dysphagia), both following the schedule with 2.2 Gy per fraction, have been observed so far. Larynx preservation was achieved in 25/26 of the definitively irradiated patients (one underwent a salvage laryngectomy); 23 had no or minimal dysphagia (G0-1). Conclusion: excellent early disease control and high patient satisfaction with swallowing function in HC following SIB IMRT were observed; these results need to be confirmed based on a longer follow-up period. In order to avoid G4 reactions, SIB doses of < 2.2 Gy/fraction are recommended for large tumors involving laryngeal structures. (orig.)

  3. ABT-751 in Treating Young Patients With Refractory Solid Tumors

    Science.gov (United States)

    2012-03-14

    Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Kidney Cancer; Liver Cancer; Neuroblastoma; Ovarian Cancer; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific

  4. At the double for tumor suppressor

    Science.gov (United States)

    2016-01-01

    Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost. PMID:27421119

  5. Cushing syndrome due to adrenal tumor

    Science.gov (United States)

    Adrenal tumor - Cushing syndrome ... Cushing syndrome is a disorder that occurs when your body has a higher than normal level of the ... or cancerous (malignant). Noncancerous tumors that can cause ... Adrenal adenomas Micronodular hyperplasia Cancerous tumors that ...

  6. Brain and Spinal Tumors: Hope through Research

    Science.gov (United States)

    ... and worsen as the tumor grows. The most obvious sign of a brain tumor in infants is ... blood flow, antidepressants to treat anxiety or ease depression that might occur following a tumor diagnosis, and ...

  7. Epidemiology of Neuroendocrine Tumors.

    Science.gov (United States)

    Fraenkel, Merav; Faggiano, Antongiulio; Valk, Gerlof D

    2015-01-01

    Formerly named carcinoids, neuroendocrine tumors originate from diffuse endocrine cells, can involve any part of the gastrointestinal tract, endocrine pancreas and bronchopulmonary (BP) tree, and have a wide range of malignant potential. This chapter summarizes the data available on the epidemiology of neuroendocrine neoplasia (NEN) from around the world, including the relative frequency according to organ of origin, annual incidence rates (IR) and trends in IR at the various anatomic sites, age and stage at presentation, racial and gender differences in IR and 5-year survival rates. Over time, changes have been made in the classification and registration of NEN, both in the same registry and across the globe, thus confounding the possibility to draw conclusions as to the true rise in IR of NEN that is observed all over the world. BP NEN has become the most common site in many western countries, while NEN of the rectum is more common in the Far East. In some countries, appendiceal NEN is the most common site in females. When compared to adenocarcinoma of the same location, the prognosis of NEN patients is better. Five-year survival rates are highest for NEN originating in the rectum and appendix, but lower in small intestinal and pancreatic NEN. Future research is needed to understand the contribution of genetic and environmental factors to NEN epidemiology. PMID:26303701

  8. Tumores neonatales y malformaciones congénitas

    Science.gov (United States)

    Tornero, O. Berbel; García, J.A. Ortega; Tortajada, J. Ferrís i; Castell, J. García; Colomer, J. Donat i; Soldin, O.P.; Soler, J.L. Fuster

    2013-01-01

    Introducción La asociación entre tumores y malformaciones congénitas está bien establecida, pero no existen datos exclusivos en el período neonatal y se desconocen los mecanismos subyacentes que generan dicha relación. Objetivos Este trabajo tiene dos objetivos: primero, analizar la frecuencia de los tumores neonatales asociados a malformaciones congénitas, y segundo, comentar las posibles hipótesis etiopatogénicas de la relación entre ambas entidades. Materiales y método Estudio retrospectivo de las historias clínicas de los tumores neonatales, en el Hospital Universitario Materno- Infantil La Fe de Valencia, desde enero de 1990 hasta diciembre de 1999. Selección y descripción de las variedades histológicas asociadas a malformaciones congénitas. Éstas se han agrupado siguiendo los criterios de la Clasificación Internacional de Enfermedades CIE-9, códigos 740.0–759.9. Revisión sistemática bibliográfica de los últimos 25 años, obtenida del Medline, Cancerlit, Index Citation Science y Embase. El perfil de búsqueda utilizado fue la combinación de “neonatal/congenital-tumors/cancer/neoplasms” y “congenital malformations/birth defects”. Resultados Se identificaron 72 tumores neonatales (2,8 % del total de tumores pediátricos diagnosticados en dichos años) y 15 de ellos (20,8 %) asociados a malformaciones congénitas, enfermedades o síndromes congénitos. Las asociaciones entre tumores neonatales y malformaciones congénitas fueron las siguientes: a) angioma en 3 pacientes: con dos cardiopatías congénitas y una atresia de coanas-laringomalacia; b) neuroblastoma en 2 pacientes: uno con riñón en herradura y anomalías vertebrales, y otro con cardiopatía congénita; c) teratoma en 2 pacientes: uno con fisura palatina y anomalías vertebrales, y otro con metatarso varo; d) tumor del sistema nervioso central en un paciente con hernia de Bochdaleck; e) tumor cardíaco en 4 pacientes con esclerosis tuberosa; f) leucemia aguda en un

  9. Isolation and evaluation of cytotoxic potential of phenolic derivatives from Schinus terebinthifolius Raddi (Anacardiaceae); Isolamento e avaliacao do potencial citotoxico de derivados fenolicos de Schinus terebinthifolius Raddi (Anacardiaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Jeferson S.; Sartorelli, Patricia; Lago, Joao Henrique G. [Universidade Federal de Sao Paulo (UNIFESP), Diadema, SP (Brazil). Inst. de Ciencias Ambientais, Quimicas e Farmaceuticas; Matsuo, Alisson L., E-mail: joao.lago@unifesp.br [Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP (Brazil). Dept. de Micro, Imuno e Parasitologia

    2012-07-01

    The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H{sub 2}O and hexane, CH{sub 2}Cl{sub 2}, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive. (author)

  10. Comparison of the automated evaluation of phantom mama in digital and digitalized images; Comparacao da avaliacao automatizada do phantom mama em imagens digitais e digitalizadas

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Priscila do Carmo, E-mail: pcs@cdtn.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear. Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Fac. de Medicina. Dept. de Propedeutica Complementar; Gomes, Danielle Soares; Oliveira, Marcio Alves; Nogueira, Maria do Socorro, E-mail: mnogue@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    Mammography is an essential tool for diagnosis and early detection of breast cancer if it is provided as a very good quality service. The process of evaluating the quality of radiographic images in general, and mammography in particular, can be much more accurate, practical and fast with the help of computer analysis tools. This work compare the automated methodology for the evaluation of scanned digital images the phantom mama. By applied the DIP method techniques was possible determine geometrical and radiometric images evaluated. The evaluated parameters include circular details of low contrast, contrast ratio, spatial resolution, tumor masses, optical density and background in Phantom Mama scanned and digitized images. The both results of images were evaluated. Through this comparison was possible to demonstrate that this automated methodology is presented as a promising alternative for the reduction or elimination of subjectivity in both types of images, but the Phantom Mama present insufficient parameters for spatial resolution evaluation. (author)

  11. Isolation and cytotoxicity evaluation of some oxoaporphine alkaloids from Annonaceae; Isolamento e avaliacao da atividade citotoxica de alguns alcaloides oxaporfinicos obtidos de annonaceae

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Denise Brentan da; Matos, Maria de Fatima Cepa; Nakashita, Simone T.; Misu, Carina K.; Yoshida, Nidia Cristiane; Carollo, Carlos Alexandre; Fabri, Joao Roberto; Miglio, Hercules da Silva; Siqueira, Joao Maximo de [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Centro de Ciencias Biologicas e da Saude. Dept. de Farmacia]. E-mail: jmaximo@nin.ufms.br

    2007-07-01

    A different methodology was used to isolate and purify oxoaporphine alkaloids, as they are difficult to separate by the usual workup when in mixture. Alkaloid extracts from Annonaceae species were obtained by base/acid extraction. The extracts were concentrated and submitted to partition in solutions of acids of different pKa values, followed by separation by preparative TLC using 1 mm thick silica gel impregnated with oxalic acid (11.2% w/w). Liriodenine, lisycamine, lanuginosine, and O-methylmoschatoline were obtained and tested against tumoral cells (line Hep{sub 2}, ATCC-CCL 23, larynx carcinoma). Only O-methylmoschatoline (IC{sub 50} 12.4 muM) was more active than cisplatin (18.0 muM). (author)

  12. Malignant renal tumors in pediatrics

    International Nuclear Information System (INIS)

    Introduction: Professionals who work in pediatric oncology, we see childhood cancer as a common disease, but in fact constitutes about 2% of all cancers diagnosed worldwide. Wilms tumor accounts for 6% of all childhood tumors and presentation bilateral accounts for 4-6% of all Wilms tumors diagnosed. Theoretical Framework: In the period between the year 1994-2003 period were attended in the Pediatric Hematology-Oncology Center, a total of 29 cases of malignant renal tumors, corresponding to 86% (25 cases) to Wilms tumor or nephroblastoma tumor. The Wilms is of embryonic origin, capable of metastatic spread, (85% lungs 15% liver). Very sensitive to chemotherapy and radiotherapy, which confers high cure rates (85%); having a multidisciplinary treatment model, combining surgery, chemotherapy, and radiotherapy. The role of nursing in comprehensive cancer care child is essential in the prevention and early detection of side effects or complications. Case report: S.D. currently 10 years old. In 10/1994, at 8 months of age, was diagnosed with bilateral Wilms tumor. On admission her weight was 8200gr with abdominal circumference 50cm. Conducted pre-operative MDT and 02/1995 nephrectomy of the left kidney and right kidney lumpectomy (tumor nodule 420gr. and a 250gr.). MDT begins in 03/1995 01/1996 ending. 09/2003 with abdominal pain and vomiting, and kidney failure. 10/2003 lumpectomy biopsy (sclerotic nodule associated with maturation nephroblastoma). Currently severe renal insufficiency plan enters dialysis. Nursing process: Objectives: 1) To prepare the child and family to the side effects and possible complications of chemotherapy and / or radiotherapy 2) Prevent and minimize related complications tumor and / or treatment. Care Plan comprises four stages: A) rating and customer income. B) Implement care chemotherapy C) post-operative Care D) Implement radiation care

  13. Are tumor-to-tumor differences in oxygenation responsible for the heterogeneity in the response of tumors to therapy

    International Nuclear Information System (INIS)

    Individual tumors from the same transplanted tumor line often show very different responses to the same treatments, even when the tumors are implanted into similar sites in similar hosts and studied at the same time. The cause of this heterogeneity is unknown; either tumor or host factors could be responsible. Solid tumors contain large numbers of viable hypoxic cells, which are resistant to both radiotherapy and chemotherapy and limit the response of tumors to intensive treatments. To determine whether differences in the proportion of hypoxic cells in the tumors produce the observed variability in therapeutic sensitivity, the authors compared the radiation responses of normally-aerated tumors and tumors made artificially hypoxic. If large tumor-to-tumor differences in oxygenation exist, data from normally-aerated tumors should be more variable than data from hypoxic tumors (which should all be brought to uniform hypoxia and uniform radioresistance). Analysis of data from several tumor systems revealed the variability in the radiation responses of hypoxic tumors to be at least as great as that for aerobic tumors. Thus, factors other than differences in oxygenation must produce the heterogeneity in tumor radiation response

  14. Tumor cure and tumor cell survival kinetics after photoradiation treatment in vivo in two experimental mouse tumor systems

    International Nuclear Information System (INIS)

    To study the question whether tumor destruction by photoradiation therapy (PRT) in vivo is due to direct tumor cell kill or whether it is a consequence of damage to the tumor support structures, the authors have used the EMT-6 and RIF in vivo-in vitro tumor systems, which allow colony formation survival assay of tumor cells treated with PRT in vivo. The EMT-6 tumor showed no significant reduction in tumor cell clonogenicity at the completion of PRT at doses which are curative to the tumor. However, when the tumors were allowed to remain in situ for varying lengths of time (1-24 h) after PRT, tumor cell death occurred rapidly and progressively. Very similar tumor cell survival kinetics were found in RIF tumors, although cure of these tumors by PRT is rare. The pattern of tumor cell death following PRT in vivo closely matches that of tumors deprived of oxygen, implying that one of the major factors leading to tumor destruction by PRT may be the shut-down of tumor vasculature, which has been shown to be one of the initial effects of PRT

  15. Mobile Network DoS Attack and Detection Technology

    Directory of Open Access Journals (Sweden)

    K. Krishnamoorthy

    2013-09-01

    Full Text Available Currently, there has been a 3G mobile networks data traffic explosion due to the large increase in the number of smartphone users. Unlike a traditional wired infrastructure, 3G mobile networks have limited wireless resources and signaling procedures for complex wireless resource management and mobile network security for various abnormal and malicious traffic technologies was not ready. So Malicious or potentially malicious traffic originating from mobile malware infected smart devices can cause serious problems to the 3G mobile networks, such as DoS and scanning attack in wired networks. This paper describes the DoS security threat in the 3G mobile network and proposes a detection technology.

  16. ECONOMIA DOS RECURSOS HUMANOS: TEORIA E EVIDÊNCIAS

    Directory of Open Access Journals (Sweden)

    Andre Carraro

    2014-12-01

    Full Text Available Este trabalho tem como objetivo discutir as diversas contribuições dadas ao longo das últimas décadas à economia dos recursos humanos, uma área de crescente destaque tanto entre a comunidade acadêmica, quanto entre empresários e trabalhadores. Discutem-se os diversos tópicos que compõem as abrangentes relações empresariais, estabelecidos na literatura em quatro tópicos principais: treinamento, incentivos, organização e seleção de pessoas. É feita uma análise dos principais artigos e autores de cada uma dessas subáreas, com o intuito principal de facilitar o acesso à informação, apontar caminhos para novas pesquisas e incentivar potenciais pesquisadores.

  17. Aventuras de diagrama no país dos signos

    Directory of Open Access Journals (Sweden)

    Renira Rampazzo Gambarato

    2014-01-01

    Full Text Available Este artigo aborda as variabilidades do conceito de diagrama pelo viés da Teoria Geral dos Signos ou Semiótica, de Charles Sandres Peirce (1839-1914, e da Teoria Geral dos Sistemas, de Mario Bunge ( 1919 - ... . Etimologicamente, diagrama significa através da linguagem: diágramma, do grego, nasce da junção de dia (através de e gramma (medida de linguagem. No senso comum, seu significado se restringe a um gráfico, o que absolutamente não corresponde à complexidade do termo. Por se tratar de uma representação visual, os diagramas trazem aos nossos olhos a possibilidade de observar as relações neles contidas, relações estas que não necessariamente estavam visíveis antes da construção do diagrama.

  18. Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy

    Science.gov (United States)

    Van de Giessen, Martijn; Schaafsma, Boudewijn E.; Charehbili, Ayoub; Smit, Vincent T. H. B. M.; Kroep, Judith R.; Lelieveldt, Boudewijn P. F.; Liefers, Gerrit-Jan; Chan, Alan; Löwik, Clemens W. G. M.; Dijkstra, Jouke; van de Velde, Cornelis J. H.; Wasser, Martin N. J. M.; Vahrmeijer, Alexander L.

    2015-02-01

    Diffuse optical spectroscopy (DOS) may be advantageous for monitoring tumor response during chemotherapy treatment, particularly in the early treatment stages. In this paper we perform a second analysis on the data of a clinical trial with 25 breast cancer patients that received neoadjuvant chemotherapy. Patients were monitored using delayed contrast enhanced MRI and additionally with diffuse optical spectroscopy at baseline, after 1 cycle of chemotherapy, halfway therapy and before surgery. In this analysis hemoglobin content between tumor tissue and healthy tissue of the same breast is compared on all four monitoring time points. Furthermore, the predictive power of the tumor-healthy tissue difference of HbO2 for non-responder prediction is assessed. The difference in HbO2 content between tumor and healthy tissue was statistically significantly higher in responding tumors than in non-responding tumors at baseline (10.88 vs -0.57 μM, P=0.014) and after one cycle of chemotherapy (6.45 vs -1.31 μM, P=0.048). Before surgery this difference had diminished. In the data of this study, classification on the HbO2 difference between tumor and healthy tissue was able to predict tumor (non-)response at baseline and after 1 cycle with an area-under-curve of 0.95 and 0.88, respectively. While this result suggests that tumor response can be predicted before chemotherapy onset, one should be very careful with interpreting these results. A larger patient population is needed to confirm this finding.

  19. Entre combos e enigmas: a complexidade da narrativa dos games

    Directory of Open Access Journals (Sweden)

    Pinheiro, Cristiano Max Pereira

    2005-01-01

    Full Text Available O presente estudo aborda o universo dos games e, como uma forma de realizar uma investigação completa do assunto, invade também questões referentes ao cinema, à televisão, à literatura, aos quadrinhos e à música. Devido à extrema diversidade do formato aqui estudado, optou-se por focalizar a análise em dois conceitos fundamentais: narrativa e interatividade.

  20. Dos nuevas especies de colostethus (amphibia, dendrobatidae) de colombia

    OpenAIRE

    Rivero, Juan A.; Serna, Marco A.

    2012-01-01

    Hasta el momento de escribirse este trabajo se conocían 28 especies deColostethus en Colombia, pero cinco de estas, mencionadas en el trabajo detesis de S. R. EDWARS (1974), todavía no han sido descritas. Las dos especiesque se describen aqui han sido examinadas por W. DUELLMAN, del Museo deHistoria Natural de la Universidad de Kansas (en donde esta depositado elmaterial de EDWARDS), quien ha certificado que no se trata de ninguna desus especies.

  1. Ensino Religioso: espaço dos catecismos

    Directory of Open Access Journals (Sweden)

    Sergio Rogerio Junqueira

    2015-01-01

    Full Text Available Este artigo é resultado da pesquisa qualitativa histórica documental sobre a construção da disciplina do Ensino Religioso a partir dos livros didáticos. Uma das estratégias para compreender a formação dos componentes curriculares no espaço da escola, sendo uma instituição da modernidade que está intimamente relacionada ao projeto da sociedade burguesa urbano-industrial, é refletir como seus caracteres são construídos. A escola vem desempenhando a função de formar e conformar os sujeitos individuais e coletivos aos padrões de racionalização e burocratização dessa sociedade. Embora outras instituições sociais realizem a mesma tarefa, cabe à escola o papel de transmitir os saberes legitimados, fundamental para atender às demandas sociais. Os componentes curriculares colaboram nesta mediação e, dentre outros, é no Ensino Religioso que se percebe concretizado especialmente pelos livros didáticos, que por meio de seus textos e exercícios expressam saberes a serem transmitidos. Compreende-se que por meio dos livros didáticos é possível verificar o desenvolvimento desta disciplina, especialmente em sua origem quando era denominada aula de religião, e que pretendia consolidar o projeto de uma religião hegemônica do país, através de seus catecismos como instrumento de ensino de inúmeras gerações.

  2. Wascyli Simões dos Anjos: metodologias EMUFRN

    OpenAIRE

    Gouveia, Rodrigo Borges Lima

    2014-01-01

    Este estudo está voltado para as metodologias utilizadas no ensino da flauta, desenvolvidas pelo professor Wascyli Simões dos Anjos na EMUFRN. Adotou-se como pressuposto ultrapassar a ideia simplesmente metodológica. Desta forma, a metodologia de ensino da flauta transversal, concretizada pelo professor Wascyli, é tratada como um ensino humanista e humanizado, relacionado a uma racionalidade social onde estão envolvidos comportamentos, valores e saberes. Para tanto, buscou-se investigar os as...

  3. Hypercalcemia in Tumor Lysis Syndrome

    OpenAIRE

    Shah, Binay Kumar

    2013-01-01

    Tumor lysis syndrome (TLS) is characterized by hyperkalemia, hyperuricemia, hypocalcemia and hyperphosphatemia. This report describes a case of hypercalcemia in TLS in a patient with diffuse large B cell lymphoma.

  4. Desmoid tumors and deep fibromatoses.

    Science.gov (United States)

    Schlemmer, Marcus

    2005-06-01

    Desmoid tumors (also called deep fibromatoses) are rare benign tumors associated with pregnancy and Gardner syndrome. These tumors are characterized by bland-appearing fibroblasts, indistinct margins, and an ability to cause pathology by local invasion and recurrence. They arise in the abdominal cavity, in the abdominal wall, or in the extremities/trunk, each with a slightly different biologic behavior. Though they are not cancer and do not metastasize, desmoids can cause significant morbidity and occasionally death through local/regional invasion of critical structures. Treatment primarily is surgical, although radiation or systemic therapy can be beneficial to the patient when surgery is not feasible. This article highlights the biology and clinical features of desmoid tumors.

  5. Infantile pericardial round cell tumor

    International Nuclear Information System (INIS)

    Cardiac malignancies presenting in infancy are rare. Desmoplastic small round cell tumor (DSRCT) is a rare occurrence in this age group. No case of intrapericardial DSRCT has been reported in the literature in infants

  6. Tumor Acidity as Evolutionary Spite

    Directory of Open Access Journals (Sweden)

    Mohammed E. A. Shayoub

    2011-01-01

    Full Text Available Most cancer cells shift their metabolic pathway from a metabolism reflecting the Pasteur-effect into one reflecting the Warburg-effect. This shift creates an acidic microenvironment around the tumor and becomes the driving force for a positive carcinogenesis feedback loop. As a consequence of tumor acidity, the tumor microenvironment encourages a selection of certain cell phenotypes that are able to survive in this caustic environment to the detriment of other cell types. This selection can be described by a process which can be modeled upon spite: the tumor cells reduce their own fitness by making an acidic environment, but this reduces the fitness of their competitors to an even greater extent. Moreover, the environment is an important dimension that further drives this spite process. Thus, diminishing the selective environment most probably interferes with the spite process. Such interference has been recently utilized in cancer treatment.

  7. Tumor Acidity as Evolutionary Spite

    Energy Technology Data Exchange (ETDEWEB)

    Alfarouk, Khalid O., E-mail: khalid.alfarouk@act.sd [Department of Biotechnology, Africa City of Technology, Khartoum (Sudan); Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum (Sudan); Muddathir, Abdel Khalig [Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum (Sudan); Shayoub, Mohammed E. A. [Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum (Sudan)

    2011-01-20

    Most cancer cells shift their metabolic pathway from a metabolism reflecting the Pasteur-effect into one reflecting the Warburg-effect. This shift creates an acidic microenvironment around the tumor and becomes the driving force for a positive carcinogenesis feedback loop. As a consequence of tumor acidity, the tumor microenvironment encourages a selection of certain cell phenotypes that are able to survive in this caustic environment to the detriment of other cell types. This selection can be described by a process which can be modeled upon spite: the tumor cells reduce their own fitness by making an acidic environment, but this reduces the fitness of their competitors to an even greater extent. Moreover, the environment is an important dimension that further drives this spite process. Thus, diminishing the selective environment most probably interferes with the spite process. Such interference has been recently utilized in cancer treatment.

  8. Tracking Tumor Evolution through Mathematics.

    Science.gov (United States)

    Leslie, Mitch

    2016-04-01

    A recent study suggests that many cancers undergo neutral evolution, with all key mutations present at the start of malignancy. New mutations acquired along the way don't confer any advantages on tumor cells.

  9. Stages of Gastrointestinal Carcinoid Tumors

    Science.gov (United States)

    ... carcinoid tumors include the following: Having a family history of multiple endocrine neoplasia type 1 (MEN1) syndrome or neurofibromatosis type 1 (NF1) syndrome . Having certain conditions that affect the stomach's ...

  10. Drugs Approved for Wilms Tumor

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Wilms tumor and other childhood kidney cancers. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  11. Tratamento endócrino dos meningiomas: uma revisão

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Casulari Roxo Da Motta

    1995-06-01

    Full Text Available Os meningiomas são tumores benignos do sitema nervoso central. Apresentam altas taxas de recidiva e muitas vezes são considerados inoperáveis, como quando se localizam em local de difícil acesso cirúrgico ou quando englobam estruturas nobres do cérebro. Existem evidências clínicas, epidemiológicas, bioquímicas e de experimentos "in vitro" de que seu crescimento sofre influência do meio hormonal esteróideo. Vários ensaios terapêuticos têm explorado estas características do meningioma através do uso de substâncias que interferem na ação destes esteróides: RU486 (antiprogestínico e antiglicocorticóide, acetato de medroxiprogesterona (antiprogestínico, gestrinona (antiestrogênico e antiprogestínico, tamoxifen (antiestrogênico e buserelin (superagonista do LHRH, além do octreotide (análogo da somatostatina e a bromocriptina (agonista dopaminérgico. Outros medicamentos possuem potencial para o tratamento dos meningiomas: aminoglutetimina, suramin e trapidil. Nesta revisão, analizamos a literatura sobre esses aspectos.

  12. Imaging of soft tissue tumors.

    OpenAIRE

    Einarsdóttir, Hildur

    2003-01-01

    Abstract The aim of this project on soft tissue tumors, was to evaluate existing imaging methods and test new Magnetic Resonance Imaging (MRI) sequences for diagnosis and assessment of cytotoxic therapy and to relate the imaging studies to cytology to explore the limitations of each procedure. Patients and method The studies were based on patients with a soft tissue lesion diagnosed and treated at the Orthopedic Tumor Service at the Karolinska Hospital 1990-2003. In 17...

  13. Tumor suppression by stromal TIMPs.

    Science.gov (United States)

    Shimoda, Masayuki; Jackson, Hartland W; Khokha, Rama

    2016-05-01

    The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal-tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes. PMID:27314104

  14. Digitally deconvolving the tumor microenvironment.

    Science.gov (United States)

    Aran, Dvir; Butte, Atul J

    2016-01-01

    Understanding a tumor's complex cellular heterogeneity will be crucial for the development of better treatment strategies. A new study suggests a novel method for the in silico dissociation of solid tumors and presents novel insights that have implications for immunotherapy in cancer.Please see the related Research article: www.dx.doi.org/10.1186/s13059-016-1028-7 . PMID:27549319

  15. TTP: Tool for Tumor Progression

    OpenAIRE

    Reiter, Johannes G.; Bozic, Ivana; Chatterjee, Krishnendu; Nowak, Martin A.

    2013-01-01

    In this work we present a flexible tool for tumor progression, which simulates the evolutionary dynamics of cancer. Tumor progression implements a multi-type branching process where the key parameters are the fitness landscape, the mutation rate, and the average time of cell division. The fitness of a cancer cell depends on the mutations it has accumulated. The input to our tool could be any fitness landscape, mutation rate, and cell division time, and the tool produces the growth dynamics an...

  16. Tumor Metabolism of Malignant Gliomas

    OpenAIRE

    Deliang Guo; Arnab Chakravarti; Williams, Terence M.; Peng Ru

    2013-01-01

    Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a...

  17. Integrin Trafficking and Tumor Progression

    Directory of Open Access Journals (Sweden)

    Sejeong Shin

    2012-01-01

    Full Text Available Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs.

  18. Endoscopic resection of subepithelial tumors

    OpenAIRE

    Schmidt, Arthur; Bauder, Markus; Riecken, Bettina; Caca, Karel

    2014-01-01

    Management of subepithelial tumors (SETs) remains challenging. Endoscopic ultrasound (EUS) has improved differential diagnosis of these tumors but a definitive diagnosis on EUS findings alone can be achieved in the minority of cases. Complete endoscopic resection may provide a reasonable approach for tissue acquisition and may also be therapeutic in case of malignant lesions. Small SET restricted to the submucosa can be removed with established basic resection techniques. However, resection o...

  19. Tumores testiculares na infância Testicular tumors in childhood

    Directory of Open Access Journals (Sweden)

    Roni Leonardo Teixeira

    2009-02-01

    Full Text Available Testicular and paratesticular prepuberal tumors are rare. They represent around 1% of the total of tumors of infancy. They subdivide in 2 groups: germ cells tumors and non germ cells tumors, being able to occur in all the ages, and about 75% are malignant, and about 19% of these they present metastasis. The tumors of germ cells tumors represent 60 75% of the tumors testiculars in infancy, having as main example the yolk sac tumor (65% of the neoplasms, followed for teratomas (14%; although some works to exist where teratoma, if presents as most common .The non germ cells tumors include the Leydig cell tumor and Sertoli cell tumor. The Leydig cell tumor, are most frequent between the non germ cells tumors testicular. This review article on epidemiology, diagnosis and treatment of to testicular and to paratesticular tumors in child.

  20. Tumores benignos produtores de osso na coluna: estudo de 30 casos Tumores benignos productores de hueso en la columna: estudio de 30 casos Benign spine bone tumors: case series of 30 patients

    OpenAIRE

    Osmar Avanzi; Robert Meves; Maria Fernanda Silber Caffaro; José Moussa Chalouhi

    2009-01-01

    OBJETIVO: o osteoma osteoide e o osteoblastoma são tumores benignos do osso incomuns. Diante da raridade dessas neoplasias e de literatura nacional escassa, em especial no que tange à coluna, realizou-se um estudo retrospectivo com a experiência adquirida no trato desses pacientes por 27 anos, obtendo uma expressiva série de casos para descrição dos resultados do tratamento. MÉTODOS: avaliação de prontuários e exames laboratoriais de 30 pacientes, com um seguimento médio de 47 meses, tratados...

  1. Tumores ósseos benignos e lesões ósseas Pseudotumorais: tratamento atual e novas tendências Benign bone tumors and tumor-like bone lesions: treatment update and new trends

    OpenAIRE

    José Marcos Nogueira Drumond

    2009-01-01

    O tratamento dos tumores ósseos benignos (TOB) e lesões ósseas pseudotumorais (LOP) tem visto surgir novos medicamentos, como os bisfosfonatos de uso intravenoso, que têm mostrado bons resultados no controle das lesões da displasia fibrosa. O cisto ósseo aneurismático tem sido tratado com agentes esclerosantes com sucesso. Tratamentos adjuvantes permitem a realização de cirurgias que preservam a articulação e a função, com baixas taxas de recidiva. Têm sido mais utilizados o cimento ósseo (PM...

  2. Ossifying renal tumor of infancy.

    Science.gov (United States)

    Schelling, Johannes; Schröder, Annette; Stein, Raimund; Rösch, Wolfgang H

    2007-06-01

    A renal ossifying tumor of infancy is a rare event with few cases having been published, and the etiology has not yet been established. We report on two new cases of this unusual neoplasm. A 2-year-old boy presented with intermittent painless gross hematuria. After several diagnostic procedures, an open pyelolithotomy was performed and the histological diagnosis of renal tumor of infancy was finally made. The history of the second case is very similar. An 8-week-old infant presented with gross hematuria. As in the first case, an open pyelolithotomy was performed and a tumor entirely covered with blood clots was found in the renal pelvis and completely removed. A histological diagnosis of renal ossifying tumor of infancy was made. Using the literature available, the histological criteria and biological behavior are discussed, together with the diagnostic and therapeutic algorithm for this tumor. In infants with gross hematuria and a calcified (non-)invasive mass in the pelvi-calceal system, renal ossifying tumor should be considered in the differential diagnosis. MRI or CT scan offers a good diagnostic guide.

  3. A Importância dos Carboidratos na Alimentação dos Eqüinos

    OpenAIRE

    Eliane Morgado:; Leandro Galzerano

    2008-01-01

    Os carboidratos são extremamente importantes na dieta dos eqüinos,sendo os carboidratos não estruturais as fontes primárias de energia. Os monossacarídeos são as únicas formas de carboidratos que podem ser absorvidos pelo intestino delgado e os carboidratos mais complexos são fermentados no intestino grosso, onde ocorre a fermentação microbiana. As frações dos carboidratos são definidas pelos métodos químicos ou enzimáticos utilizados nas análises, e vários são os métodos de avaliação da qual...

  4. Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors.

    Science.gov (United States)

    Pelosi, Giuseppe; Papotti, Mauro; Rindi, Guido; Scarpa, Aldo

    2014-06-01

    Currently, grading in lung neuroendocrine tumors (NETs) is inherently defined by the histological classification based on cell features, mitosis count, and necrosis, for which typical carcinoids (TC) are low-grade malignant tumors with long life expectation, atypical carcinoids (AC) intermediate-grade malignant tumors with more aggressive clinical behavior, and large cell NE carcinomas (LCNEC) and small cell lung carcinomas (SCLC) high-grade malignant tumors with dismal prognosis. While Ki-67 antigen labeling index, highlighting the proportion of proliferating tumor cells, has largely been used in digestive NETs for assessing prognosis and assisting therapy decisions, the same marker does not play an established role in the diagnosis, grading, and prognosis of lung NETs. Next generation sequencing techniques (NGS), thanks to their astonishing ability to process in a shorter timeframe up to billions of DNA strands, are radically revolutionizing our approach to diagnosis and therapy of tumors, including lung cancer. When applied to single genes, panels of genes, exome, or the whole genome by using either frozen or paraffin tissues, NGS techniques increase our understanding of cancer, thus realizing the bases of precision medicine. Data are emerging that TC and AC are mainly altered in chromatin remodeling genes, whereas LCNEC and SCLC are also mutated in cell cycle checkpoint and cell differentiation regulators. A common denominator to all lung NETs is a deregulation of cell proliferation, which represents a biological rationale for morphologic (mitoses and necrosis) and molecular (Ki-67 antigen) parameters to successfully serve as predictors of tumor behavior (i.e., identification of pathological entities with clinical correlation). It is envisaged that a novel grading system in lung NETs based on the combined assessment of mitoses, necrosis, and Ki-67 LI may offer a better stratification of prognostic classes, realizing a bridge between molecular alterations

  5. Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis

    DEFF Research Database (Denmark)

    Jiang, Xinnong; Multhaupt, Hinke; Chan, En;

    2004-01-01

    antibodies, together with immunoelectron microscopy, showed that perlecan distributed around blood vessels was of both host and tumor cell origin. Tumor-derived perlecan was also distributed throughout the tumor matrix. Blood vessels stained with rat-specific PECAM-1 antibody showed their host origin. RT101...... factor. In vivo, antisense perlecan-transfected cells generated no tumors, whereas untransfected and vector-transfected cells formed tumors with obvious neovascularization, suggesting that tumor perlecan rather than host perlecan controls tumor growth and angiogenesis....

  6. Imunoterapia Tumoral com Células Dendríticas

    OpenAIRE

    Silva, Patrícia Raquel Lima da

    2013-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas As células dendríticas (DCs) são mais as potentes células apresentadoras de antigénios (APCs) com um papel duplo na indução da imunidade inata e adaptativa, como também na indução de tolerância pelas células T. Nos últimos anos, novas formas de imunoterapia tumoral têm sido desenvolvidas, nomeadamente, estratégias que usam célul...

  7. Dos crisis, dos desenlaces: Retos realidades del empresario organizado colombiano en los años cincuenta y noventa

    Directory of Open Access Journals (Sweden)

    Angelika Rettberg

    2001-01-01

    Full Text Available El empresariado organizado nacional enfrenta principalmente dos tensiones: por un lado, la contradicción entre una estructura gremial formada por el régimen proteccionista de la política industrial de mitad de siglo pasado y las exigencias, retos y oportunidades para el empresariado organizado que ofrece una economía que se adentra en un mundo globalizado.

  8. Reforma na atencao primaria a saude e implicacoes na cultura organizacional dos Agrupamentos dos Centros de Saude em Portugal

    Directory of Open Access Journals (Sweden)

    Claudia Leone

    2014-01-01

    Full Text Available A crescente complexidade dos desafios do setor da saúde implica um aumento das responsabilidades para aqueles que nela assumem funções de gestão. Há consenso que a qualidade da força de trabalho em saúde é um fator crítico para o sucesso de qualquer reforma no setor. O objetivo desta investigação é estudar e analisar a alteração induzida por uma intervenção de formação-ação intensiva na cultura organizacional de 73 diretores executivos dos Agrupamentos dos Centros de Saúde (ACES em Portugal durante a reforma na atenção primária à saúde. Os dados foram coletados e analisados em dois períodos temporais, antes e depois da intervenção do Programa Avançado em Gestão, Governação Clínica e Liderança para os ACES, o qual teve um ano de duração. O modelo Competing Values Framework permitiu observar que, depois da intervenção de formação-ação, as percepções dos diretores executivos sobre a sua cultura organizacional se encontram mais alinhadas com a reforma da atenção primária à saúde, valorizando o tipo de práticas e valores que esta defende. É necessário continuar a monitorizar os resultados em vários períodos temporais para elaborar conclusões a esse respeito.

  9. Posterior Fossa Tumor in Children

    Directory of Open Access Journals (Sweden)

    Seyed Mahmoud TABATABAEI

    2012-06-01

    Full Text Available How to Cite this Article: Tabatabaei SM, Seddighi A, Seddighi AS. Posterior Fossa Tumor in Children. Iran. J. Child. Neurol 2012;6(2: 19-24. Objective Primary brain tumors are the most common solid neoplasms of childhood, representing 20% of all pediatric tumors. The best current estimates place the incidence between 2.76 and 4.28/100,000 children per year. Compared with brain tumors in adults, a much higher percentage of pediatric brain tumors arise in the posterior fossa. Infratentorial tumors comprise as many as two thirds of all pediatric brain tumors in some large series. Tumor types that most often occur in the posterior fossa include medulloblastoma, ependymoma, cerebellar astrocytoma and brainstem glioma. Materials & Methods All pediatric cases of posterior fossa tumor that were considered for surgery from 1981 to 2011 were selected and the demographic data including age, gender and tumor characteristics along with the location and pathological diagnosis were recorded. The surgical outcomes were assessed according to pathological diagnosis. Results Our series consisted of 84 patients (52 males, 32 females. Cerebellar symptoms were the most common cause of presentation (80.9% followed by headache (73.8% and vomiting (38.1%. The most common histology was medulloblastoma (42.8% followed by cerebellar astrocytoma (28.6%, ependymoma (14.3%, brainstem glioma (7.2% and miscellaneous pathologies (e.g., dermoid,  andtuberculoma (7.2%. Conclusion The diagnosis of brain tumors in the general pediatric population remains challenging. Most symptomatic children require several visits to a physician before the correct diagnosis is made. These patients are often misdiagnosed for gastrointestinal disorders. Greater understanding of the clinical presentation of these tumors and judicious use of modern neuroimaging techniques should lead to more efficacious therapies.References 1. Mehta V, Chapman A, McNeely PD, Walling S, Howes WJ. Latency between

  10. PET-CT imaging fusion in the assessment of head and neck carcinoma; Fusao de imagens PET-TC na avaliacao do carcinoma espinocelular de cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Denise Takehana dos [Sao Paulo Univ., SP (Brazil). Faculdade de Odontologia; Chojniak, Rubens [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Imagem; Lima, Eduardo Nobrega Pereira [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Medicina Nuclear; Cavalcanti, Marcelo Gusmao Paraiso [Universidade de Sao Paulo, SP (Brazil). Faculdade de Odontologia. Dept. de Estomatologia]. E-mail: mgpcaval@usp.br

    2006-11-15

    Objective: The authors have established a methodological approach to evaluate head and neck squamous cell carcinoma aiming at identifying and distinguishing high metabolic activity inside the lesion, combining in a single examination, functional, metabolic and morphological data simultaneously acquired by means of different non-dedicated positron emission tomography (PET)-computed tomography (CT) device. Materials and Methods: The study population included 17 patients with head and neck squamous cell carcinoma submitted to a non-dedicated {sup 18} F-FDG-PET imaging at Department of Diagnostic Imaging of Hospital do Cancer, Sao Paulo, SP, Brazil. CT and {sup 18} F-FDG-PET images were simultaneously acquired in a non-dedicated device. The original data were transferred to an independent workstation by means of the Entegra 2 NT software to generate PET-CT imaging fusion. Results: The findings were defined as positive in the presence of a well defined focal area of increased radiopharmaceutical uptake in regions not related with the normal biodistribution of the tracer. Conclusion: The fusion of simultaneously acquired images in a single examination ({sup 18}F-FDGPET and CT) has allowed the topographic-metabolic mapping of the lesion as well as the localization of high metabolic activity areas inside the tumor, indicating recidivation or metastasis and widening the array of alternatives for radiotherapy or surgical planning. (author)

  11. O valor dos valores: avaliação de uma marca global por meio dos diversos brasis culturais

    Directory of Open Access Journals (Sweden)

    Edar da Silva Añaña

    2009-06-01

    Full Text Available Este trabalho explora as influências dos valores pessoais e de outros elementos da cultura brasileira, na avaliação de uma marca de alcance mundial, por meio de quatro subculturas regionais que são utilizadas como unidades de análise. Utiliza as escalas de Rokeach (1968, 1973 para medir os valores humanos e a de Aaker (1997 para avaliar os atributos da marca, numa amostra de 308 pessoas, entre estudantes e profissionais de nível superior. O resultado confirma a existência de relações significativas entre os valores pessoais e a percepção da marca Nike, bem como a influência dos rituais, dos símbolos e de algumas variáveis demográficas, na forma como aquela marca é percebida e avaliada pelos consumidores. Confirma também a existência de diferenças significativas entre os elementos culturais das diversas subculturas, que podem ser bastante úteis na formulação de estratégias de marketing voltadas às diversas regiões do país.

  12. Computed tomography in gastrointestinal stromal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Ghanem, Nadir; Altehoefer, Carsten; Winterer, Jan; Schaefer, Oliver; Springer, Oliver; Kotter, Elmar; Langer, Mathias [Department of Diagnostic Radiology, University Hospital Freiburg, Hugstetter Strasse 55, 79106, Freiburg (Germany); Furtwaengler, Alex [Department of Abdominal Surgery, University Hospital Freiburg, Hugstetter Strasse 55, 79106, Freiburg (Germany)

    2003-07-01

    The aim of this study was to define the imaging characteristics of primary and recurrent gastrointestinal stromal tumors (GIST) in computed tomography with respect to the tumor size. Computed tomography was performed in 35 patients with histologically confirmed gastrointestinal stromal tumors and analyzed retrospectively by two experienced and independent radiologist. The following morphologic tumor characteristics of primary (n=20) and (n=16) recurrent tumors were evaluated according to tumor size, shape, homogeneity, density compared with liver, contrast enhancement, presence of calcifications, ulcerations, fistula or distant metastases and the anatomical relationship to the intestinal wall, and the infiltration of adjacent visceral organs. Small GIST (<5 cm) showed a sharp tumor margin with homogeneous density and structure on unenhanced and contrast-enhanced images, and were characterized by an intraluminal tumor growth. Intermediate sized GIST (>5-10 cm) demonstrated an irregular shape, inhomogeneous density on unenhanced and contrast-enhanced images, a combined intra- and extraluminal tumor growth with aggressive findings, and infiltration of adjacent organs in 9 primary diagnosed and 2 recurrent tumors. Large GIST (>10 cm), which were observed in 8 primary tumors and 11 recurrent tumors, showed an irregular margin with inhomogeneous density and aggressive findings, and were characterized by signs of malignancy such as distant and peritoneal metastases. Small recurrent tumors had a similar appearance as compared with large primary tumors. Computed tomography gives additional information with respect to the relationship of gastrointestinal stromal tumor to the gastrointestinal wall and surrounding organs, and it detects distant metastasis. Primary and recurrent GIST demonstrate characteristic CT imaging features which are related to tumor size. Aggressive findings and signs of malignancy are found in larger tumors and in recurrent disease. Computed tomography

  13. Kidney Tumors | Office of Cancer Genomics

    Science.gov (United States)

    Pediatric kidney tumors fall into four primary categories: Wilms tumors (~85% of all cases), clear cell sarcomas of the kidney (~5%), congenital mesoblastic nephromas (~4%), and rhabdoid tumors of the kidney (~3%). The TARGET initiative is investigating three of these tumor types.

  14. Research on the Strategy on Defense DOS/DDOS Attack on Internet%互联网防御DOS/DDOS攻击策略研究

    Institute of Scientific and Technical Information of China (English)

    王鹏

    2012-01-01

      It mainly presents the principle of DOS/DDOS attack and the variety, focuses on the strategies on defense DOS/DDOS attack. Combined with professional defense system, it discusses the construction of the defense architecture.%  主要介绍DOS/DDOS攻击的原理与种类,并着重介绍防御DOS/DDOS攻击的应对策略,并结合专业防御系统对构建专业防御体系进行了探讨。

  15. Os partidos políticos brasileiros e a internet: uma avaliação dos websites dos partidos políticos do Brasil

    OpenAIRE

    Sérgio Soares Braga; Andressa Silvério Terra França; María Alejandra Nicolás

    2009-01-01

    O objetivo do artigo é apresentar os resultados de nossa pesquisa sobre os websites dos partidos políticos brasileiros na internet. A partir do mapeamento da literatura internacional sobre o assunto, apresentamos uma proposta de avaliação dos websites dos principais partidos políticos brasileiros e apresentamos uma classificação do grau de uso da internet de todos os partidos nacionais. Aplicando uma planilha de análise de conteúdo aos websites dos 27 partidos políticos brasileiros com regist...

  16. [Pineal anlage tumor in a 8-month-old boy. The first case reported in Spanish language].

    Science.gov (United States)

    Rodríguez-Velasco, Alicia; Ramírez-Reyes, Alma Griselda

    2014-01-01

    INTRODUCCIÓN: el tumor pineal anlage es una neoplasia maligna muy poco frecuente. Aunque ya ha sido informado en la literatura, aún no se encuentra listado en la última clasificación de los tumores del sistema nervioso central de la Organización Mundial de la Salud publicada en 2007. Es un tumor primario de la pineal con diferenciación neuroepitelial y ectomesenquimal. Debido a su poca frecuencia, el entendimiento de su comportamiento biológico y su tratamiento apropiado son incompletos. En una búsqueda realizada en PubMed como pineal anlage tumor solo se identificaron siete casos informados entre 1989 y 2011. CASO CLÍNICO: niño de ocho meses de edad que fue llevado a consulta por aumento progresivo del perímetro cefálico y estrabismo convergente de dos meses de evolución. Se identificó tumor pineal conformado por glia, células ganglionares, neuroepitelio pigmentado y células musculares estriadas. Se realizó derivación ventrículo-peritoneal para mitigar la hidrocefalia y resección quirúrgica completa. El paciente recibió dos cursos de quimioterapia con carboplatino, ifosfamida y mesna. Al año permanecía asintomático.

  17. Tratamento cirúrgico dos insulinomas -- estudo de 59 casos Surgical treatment of insulinoma. Study of 59 cases

    Directory of Open Access Journals (Sweden)

    M.C.C. Machado

    1998-06-01

    Full Text Available Após a confirmação clínica e laboratorial de hiperinsulinismo, o principal problema consiste na localização precisa da lesão no parênquima pancreático, propiciando tratamento cirúrgico adequado. OBJETIVO: Analisar os métodos utilizados para o diagnóstico e localização pré e intra-operatório dos insulinomas, bem como as técnicas e os resultados do tratamento cirúrgico. MÉTODOS: Foram estudados 59 casos consecutivos de insulinoma submetidos a intervenção cirúrgica. Cada um dos métodos utilizados para a localização pré-operatória dessas lesões foi avaliado quanto à sua eficiência em confronto com os achados intra-operatórios. A palpação do pâncreas, isoladamente ou associada à ultra-sonografia intra-operatória, como métodos de localização dos insulinomas, foi também estudada. Os tipos de intervenção cirúrgica foram analisados quanto aos seus resultados imediatos e tardios. RESULTADOS: Dos 59 insulinomas, 55 eram benignos e quatro, malignos. Dos métodos utilizados para a localização pré-operatória, a ultra-sonografia foi eficiente em 28,1% dos casos, a tomografia computadorizada em 25%, a ultra-sonografia endoscópica em 27,2%, a arteriografia seletiva em 54,1% e a colheita de amostras de sangue portal para dosagem de insulina em 94,4% dos casos. A palpação bidigital, durante a intervenção cirúrgica, localizou as lesões em 54/55 casos (98,2%. A ultra-sonografia intra-operatória foi decisiva em apenas um caso. Cinco doentes apresentavam neoplasia endócrina múltipla tipo I e em todos as lesões pancreáticas eram múltiplas. Foram efetuadas 29 enucleações e 32 ressecções pancreáticas nos doentes com lesões benignas. Os doentes com lesões malignas foram submetidos a ressecções pancreáticas e quimioterapia. Não houve mortalidade, porém observaram-se complicações (fístulas em 29/59 casos. Os resultados foram bons em 98,1% dos doentes com lesões benignas. Apenas um dos doentes com

  18. Mammary gland tumors in captive African hedgehogs.

    Science.gov (United States)

    Raymond, J T; Gerner, M

    2000-04-01

    From December 1995 to July 1999, eight mammary gland tumors were diagnosed in eight adult captive female African hedgehogs (Atelerix albiventris). The tumors presented as single or multiple subcutaneous masses along the cranial or caudal abdomen that varied in size for each hedgehog. Histologically, seven of eight (88%) mammary gland tumors were malignant. Tumors were classified as solid (4 cases), tubular (2 cases), and papillary (2 cases). Seven tumors had infiltrated into the surrounding stroma and three tumors had histologic evidence of neoplastic vascular invasion. Three hedgehogs had concurrent neoplasms. These are believed to be the first reported cases of mammary gland tumors in African hedgehogs. PMID:10813628

  19. Glomus tumor of penis- A rare case

    Directory of Open Access Journals (Sweden)

    Madhuri S. Kate

    2013-01-01

    Full Text Available Glomus tumors are rare, painful, and benign soft tissue tumors of the skin arising from the glomus body, an arteriovenous thermoregulatory structure. This lesion is usually found on the extremities. Glomus tumor involving the external genital organs including penis is extremely rare. Until now, only few cases have been reported in the available literature. A 22 year old male patient presented with a painful nodule over the penis. The pathologic diagnosis was glomus tumor of the glans penis. We report herewith a case of glomus tumor of penis diagnosed on histopathologic examination. Glomus tumor, being a benign neoplasm, complete extirpation of the glomus tumor is the treatment of choice.

  20. Neuroendocrine Tumors of the Lung

    Energy Technology Data Exchange (ETDEWEB)

    Fisseler-Eckhoff, Annette, E-mail: Annette.Fisseler-Eckhoff@hsk-wiesbaden.de; Demes, Melanie [Department of Pathology und Cytology, Dr. Horst-Schmidt-Kliniken (HSK), Wiesbaden 65199 (Germany)

    2012-07-31

    Neuroendocrine tumors may develop throughout the human body with the majority being found in the gastrointestinal tract and bronchopulmonary system. Neuroendocrine tumors are classified according to the grade of biological aggressiveness (G1–G3) and the extent of differentiation (well-differentiated/poorly-differentiated). The well-differentiated neoplasms comprise typical (G1) and atypical (G2) carcinoids. Large cell neuroendocrine carcinomas as well as small cell carcinomas (G3) are poorly-differentiated. The identification and differentiation of atypical from typical carcinoids or large cell neuroendocrine carcinomas and small cell carcinomas is essential for treatment options and prognosis. Pulmonary neuroendocrine tumors are characterized according to the proportion of necrosis, the mitotic activity, palisading, rosette-like structure, trabecular pattern and organoid nesting. The given information about the histopathological assessment, classification, prognosis, genetic aberration as well as treatment options of pulmonary neuroendocrine tumors are based on own experiences and reviewing the current literature available. Most disagreements among the classification of neuroendocrine tumor entities exist in the identification of typical versus atypical carcinoids, atypical versus large cell neuroendocrine carcinomas and large cell neuroendocrine carcinomas versus small cell carcinomas. Additionally, the classification is restricted in terms of limited specificity of immunohistochemical markers and possible artifacts in small biopsies which can be compressed in cytological specimens. Until now, pulmonary neuroendocrine tumors have been increasing in incidence. As compared to NSCLCs, only little research has been done with respect to new molecular targets as well as improving the classification and differential diagnosis of neuroendocrine tumors of the lung.

  1. Evolution of sarcoma 180 (ascitic tumor in mice infected with Schistosoma mansoni

    Directory of Open Access Journals (Sweden)

    Fausto Edmundo Lima Pereira

    1986-03-01

    Full Text Available Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut.Camundongos infectados com 60 cercárias de Schistosoma mansoni tomaram-se mais resistentes ao sarcoma 180 na forma de tumor ascítico. A inoculação das células tumorais foi feita no 50º dia de infecção e a evolução do tumor foi acompanhada através dapesagem dos animais com intervalos de 48 horas. Nos camundongos infectados o ganho de peso (formação da ascite começou mais tarde e foi menor do que nos controles não infectados. Também o número de células tumorais na cavidade peritoneal 72 horas após a implantação do tumor foi menor no grupo infectado. Este aumento de resistência a um tumor transplantávelpossivelmente está relacionado ao efeito de endotoxinas sobre a atividade tumoricida dos macrofagos ativados pela infecção. A imunossupressão induzida pela infecção favorece a proliferação de bactérias da flora endógena aumentando a quantidade de endotoxinas absorvidas pelo intestino.

  2. Evaluation of morphological changes of the skin after radiation-induced injury in Wistar rats;Avaliacao de alteracoes morfologicas da pele apos lesao radioinduzida em ratos Wistar

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Cherley Borba Vieira de

    2010-07-01

    The cancer covers a heterogeneous group of more than 100 diseases with different etiology and prognosis. Radiotherapy is one of the most commonly used treatment modalities, aiming at the destruction of cancer cells, using ionizing radiation. One of the limiting factors of radiotherapy is that radiation promotes the death of tumor cells in addition to injure healthy tissue neighboring the tumor, and may cause their death. Irradiation of the skin, accidental or for therapeutic purposes can trigger many injuries culminating in fibrosis, which implies functional alteration of the body. The evaluation of morphological effects associated with skin irradiation becomes essential to develop more effective radiation strategies and decreased morbidity; and in case of accidents, proper handling of the victim.Evaluate radio-induced dermal changes using a Wistar rats model irradiated with 10, 40 and 60Gy. Male Wistar rats, aged approximately three months, were pre-anesthetized with midazolam and xylazine and anesthetized with sodium pentobarbital, shaved in the back, immobilized on polystyrene support in the prone position and irradiated with doses of 10, 40 and 60 Gy, with 4MeV nominal energy electron beams. The skin was irradiated in a 3cm{sup 2} field, and used 0.5cm of tissue equivalent material, to obtain a homogeneous dose distribution. After irradiation, the animals remained on constant evaluation, and the lesions were recorded photographically. The animals were divided into groups and were killed on the irradiation day, 5, 10, 15, 25 and 100 days after irradiation. The skin was fixed in 10% formaldehyde; the samples were embedded in paraffin and cut. The sections were stained with hematoxylin-eosin, picrosirius red and immuno stained with antibody anti-TGF beta1. Another part of the tissue was fixed in 2.5% glutaraldehyde and processed for scanning electron microscopy. It was observed macroscopically the appearance of skin lesions similar to burns on the entire

  3. Expression of Hyaluronan in human tumor progression

    Directory of Open Access Journals (Sweden)

    Boregowda Rajeev K

    2006-01-01

    Full Text Available Abstract Background The development and progression of human tumors is accompanied by various cellular, biochemical and genetic alterations. These events include tumor cells interaction with extracellular matrix molecules including hyaluronan (HA. Hyaluronan is a large polysaccharide associated with pericellular matrix of proliferating, migrating cells. Its implication in malignant transformation, tumor progression and with the degree of differentiation in various invasive tumors has well accepted. It has been well known the role HA receptors in tumor growth and metastasis in various cancer tissues. Previously we have observed the unified over expression of Hyaluronic Acid Binding Protein (HABP, H11B2C2 antigen by the tumor cells in various types progressing tumor tissues with different grades. However, the poor understanding of relation between HA and HA-binding protein expression on tumor cells during tumor progression as well as the asymmetric observations of the role of HA expression in tumor progression prompted us to examine the degree of HA expression on tumor cells vs. stroma in various types of human tumors with different grades. Methods In the present study clinically diagnosed tumor tissue samples of different grades were used to screen the histopathological expression of hyaluronan by using b-PG (biotinylated proteoglycan as a probe and we compared the relative HA expression on tumor cells vs. stroma in well differentiated and poorly differentiated tumors. Specificity of the reaction was confirmed either by pre-digesting the tissue sections with hyaluronidase enzyme or by staining the sections with pre-absorbed complex of the probe and HA-oligomers. Results We show here the down regulation of HA expression in tumor cells is associated with progression of tumor from well differentiated through poorly differentiated stage, despite the constant HA expression in the tumor associated stroma. Conclusion The present finding enlighten the

  4. Cancer stem cells and brain tumors

    OpenAIRE

    Pérez Castillo, Ana; Aguilar Morante, Diana; Morales-García, José A.; Dorado, Jorge

    2008-01-01

    Besides the role of normal stem cells in organogenesis, cancer stem cells are thought to be crucial for tumorigenesis. Most current research on human tumors is focused on molecular and cellular analysis of the bulk tumor mass. However, evidence in leukemia and, more recently, in solid tumors suggests that the tumor cell population is heterogeneous. In recent years, several groups have described the existence of a cancer stem cell population in different brain tumors. These neural cancer stem ...

  5. Cancer stem cells, tumor dormancy, and metastasis

    OpenAIRE

    EmilyChen

    2012-01-01

    Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence, drug resistance, and metastasis, and opens up new research directions on how cancer cells are capable of switching from dormancy to malignanc...

  6. Estudo retrospectivo de 207 casos de tumores mamários em gatas

    Directory of Open Access Journals (Sweden)

    Monique Togni

    2013-03-01

    Full Text Available Este estudo teve como objetivos determinar os tumores mais prevalentes em gatos e relacionar os tumores mamários a alguns de seus fatores prognósticos. Os arquivos do Laboratório de Patologia Veterinária (LPV da Universidade Federal de Santa Maria (UFSM foram revisados e um total de 1.427 protocolos de biopsias e necropsias de felinos, entre 2000 e 2011, foi encontrado. Com base nas informações dos arquivos, foi estabelecida a relação entre os tumores e alguns fatores como sexo, idade, raça, estado reprodutivo, uso de contraceptivos, número e localização das glândulas afetadas, ulcerações, tamanho do neoplasma, metástases distantes e para os linfonodos. Assim, observou-se que os tumores de mama foram o segundo diagnóstico mais prevalente, após os tumores de pele. Todos os gatos com tumores mamários eram fêmeas, sendo os sem raça definida e os idosos os mais afetados. Os neoplasmas malignos foram diagnosticados com maior frequência, seguidos pelos tumores não neoplásicos e pelos neoplasmas benignos. Os tumores menores eram, na sua maioria, carcinomas. Ulcerações estavam presentes não só em neoplasmas malignos, mas também em alterações não neoplásicas. Metástases distantes foram encontradas principalmente nos pulmões e na pele.

  7. TENDÊNCIAS DOS ESTUDOS COM PLANTAS MEDICINAIS NO BRASIL

    Directory of Open Access Journals (Sweden)

    Fernanda Melo Carneiro

    2014-12-01

    Full Text Available As plantas medicinais são utilizadas pelo homem desde o início da história e atualmente empregadas como recursos na medicina alternativa por grande parte da população mundial. Esse uso deve-se à facilidade de acesso às plantas em relação aos medicamentos alopáticos. O objetivo deste trabalho foi, primariamente, desenvolver uma análise cienciométrica sobre as tendências dos estudos com plantas medicinais no Brasil, investigando se o número de trabalhos cresceu ao longo dos anos. Além disso, foi identificamos as principais plantas que são estudadas pelo seu principio medicinal no Brasil. Para a pesquisa foi empregada a base de dados Scielo, com artigos de 1995 a 2011, utilizando a palavra “Planta Medicinal” como palavra-chave. Foram avaliados 329 artigos, mas somente 265 foram compatíveis à pesquisa. Artigos que não foram desenvolvidos no Brasil; que não utilizaram o termo planta medicinal; ou não citaram plantas foram excluídos das análises. Em cada artigo selecionado foram coletadas as seguintes informações: título do artigo, quantidade de autores, instituições responsáveis pelo estudo, local das instituições, ano de publicação, tipo de estudo (ex.: farmacológico, agropecuário e ecológico e as plantas que foram estudadas. Por meio de análises desses dados foi possível verificar as tendências dos estudos com plantas medicinais no Brasil. Conforme esperado, a maior parte dos artigos avaliados estão voltados para a Farmacologia, com aplicação em diversas áreas da saúde e em segundo lugar a Agropecuária, devido ao interesse em desenvolver produtos a partir de plantas para o controle de pragas. Entretanto, verificou-se o emprego em outras áreas, como a Bioquímica, Botânica, Ecologia, Genética/Molecular e Educação que apesar de serem menos frequentes, são essenciais, pois os estudos com plantas medicinais requerem profissionais de múltiplas áreas. Além da investigação da medicina popular

  8. Embolismo tumoral pulmonar microvascular en paciente con tumor urotelial

    OpenAIRE

    B. de Escalante Yangüela; J. Rubio Gracia; G. Muñoz González; B. Gracia Tello; M. Rodero Roldán; V. Alastrué del Castaño

    2015-01-01

    Los embolismos tumorales pulmonares (ETP) representan una causa poco frecuente de disnea en pacientes oncológicos. La mayoría se diagnostican en pacientes con tumores avanzados, sobre todo localizados en mama, pulmón o estómago. Existen pocos casos publicados en pacientes con tumores uroteliales. Presentamos el caso de un varón de 69 años, sin diagnóstico previo de cáncer, que ingresó por disnea subaguda, con sospecha clínica inicial de tromboembolismo pulmonar (TEP). El paciente falleció al ...

  9. [Cartilage tumors : Pathology and radiomorphology].

    Science.gov (United States)

    Uhl, M; Herget, G; Kurz, P

    2016-06-01

    Primary cartilage-forming tumors of the bone are frequent entities in the daily work of skeletal radiologists. This article describes the correlation of pathology and radiology in cartilage-forming skeletal tumors, in particular, enchondroma, osteochondroma, periosteal chondromas, chondroblastoma and various forms of chondrosarcoma. After reading, the radiologist should be able to deduce the different patterns of cartilage tumors on radiographs, CT, and MRI from the pathological aspects. Differentiation of enchondroma and chondrosarcoma is a frequent diagnostic challenge. Some imaging parameters, e. g., deep cortical scalloping (more than two thirds of the cortical thickness), cortical destruction, or a soft-tissue mass, are features of a sarcoma. Osteochondromas are bony protrusions with a continuous extension of bone marrow from the parent bone, the host cortical bone runs continuously from the osseous surface of the tumor into the shaft of the osteochondroma and the osteochondroma has a cartilage cap. Chondromyxoid fibromas are well-defined lytic and eccentric lesions of the metaphysis of the long bones, with nonspecific MRI findings. Chondroblastomas have a strong predilection for the epiphysis of long tubular bones and develop an intense perifocal bone marrow edema. Dedifferentiated chondrosarcomas are bimorphic lesions with a low-grade chondrogenic component and a high-grade noncartilaginous component. Most chondrogenic tumors have a predilection with regard to site and age at manifestation. PMID:27233920

  10. Tumor ablation with irreversible electroporation.

    Directory of Open Access Journals (Sweden)

    Bassim Al-Sakere

    Full Text Available We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the cell membrane. Mathematical models of the electrical and thermal fields that develop during the application of the pulses were used to design an efficient treatment protocol with minimal heating of the tissue. Tumor regression was confirmed by histological studies which also revealed that it occurred as a direct result of irreversible cell membrane permeabilization. Parametric studies show that the successful outcome of the procedure is related to the applied electric field strength, the total pulse duration as well as the temporal mode of delivery of the pulses. Our best results were obtained using plate electrodes to deliver across the tumor 80 pulses of 100 micros at 0.3 Hz with an electrical field magnitude of 2500 V/cm. These conditions induced complete regression in 12 out of 13 treated tumors, (92%, in the absence of tissue heating. Irreversible electroporation is thus a new effective modality for non-thermal tumor ablation.

  11. Awake craniotomy for tumor resection

    Directory of Open Access Journals (Sweden)

    Mohammadali Attari

    2013-01-01

    Full Text Available Surgical treatment of brain tumors, especially those located in the eloquent areas such as anterior temporal, frontal lobes, language, memory areas, and near the motor cortex causes high risk of eloquent impairment. Awake craniotomy displays major rule for maximum resection of the tumor with minimum functional impairment of the Central Nervous System. These case reports discuss the use of awake craniotomy during the brain surgery in Alzahra Hospital, Isfahan, Iran. A 56-year-old woman with left-sided body hypoesthesia since last 3 months and a 25-year-old with severe headache of 1 month duration were operated under craniotomy for brain tumors resection. An awake craniotomy was planned to allow maximum tumor intraoperative testing for resection and neurologic morbidity avoidance. The method of anesthesia should offer sufficient analgesia, hemodynamic stability, sedation, respiratory function, and also awake and cooperative patient for different neurological test. Airway management is the most important part of anesthesia during awake craniotomy. Tumor surgery with awake craniotomy is a safe technique that allows maximal resection of lesions in close relationship to eloquent cortex and has a low risk of neurological deficit.

  12. Depois do pacote e dos cortes de bolsas

    Directory of Open Access Journals (Sweden)

    Romano Roberto

    1998-01-01

    Full Text Available Este texto teve origem em palestra subordinada ao tema "Cenário Nacional da Educação Brasileira e Pós-graduação". Retoma teses do etnólogo Andre Leroi-Gourhan, sobre origem e desenvolvimento das técnicas e dos saberes humanos, confrontando-as com momentos desse processo na educação e na pesquisa que se fez no Brasil, ao longo da história. Aponta-se, desse modo, para as dimensões reduzidas do sistema de ciência e tecnologia aqui produzido, quando confrontado com as necessidades de adaptação ao meio tecnológico mundial, ameaçando de modo permanente a própria adaptação ao meio natural. Investir em saúde, educação, ciência e técnica não é algo que possa ser visto pelo ângulo financeiro: investimentos nestes setores definem, em termos econômicos e antropológicos, a sobrevivência e a expansão bioetnológica de um povo. Sem eles, o que se faz, na verdade, é condenar o coletivo inteiro à morte lenta. Salvo, é claro, os pequenos setores que escapam do inferno, integrando-se em outros coletivos, usando privilégios e tornando-se parte de outros povos. O que podemos fazer? No plano político mais amplo, controle sobre o Executivo, por parte dos outros poderes da República. No plano das universidades, ação dos órgãos colegiados sobre a política da administração, bem como sobre as políticas de financiamento e fomento à pesquisa.

  13. As Limitações dos Sistemas de Metas

    Directory of Open Access Journals (Sweden)

    Mário Teixeira Reis Neto

    2011-04-01

    Full Text Available Neste ambiente de grandes incertezas em que as organizações estão inseridas, a correta utilização de um sistema de medição pode significar vantagem competitiva e desempenho. Este ensaio procura esclarecer os limites dos sistemas de medição, verificando se a utilização de metas de resultado é suficiente para que uma empresa tenha um desempenho superior. O objetivo é analisar a teoria das metas sob um olhar crítico, observando os limites da utilização de diversos tipos de metas, até mesmo no serviço público. Buscou-se fazer uma análise das pesquisas dos autores que defendem a utilização de metas para se ter desempenho e, a partir das suas premissas, analisar os estudos dos autores que as criticam, mostrando que elas podem causar, dependendo da situação, sérios danos financeiros e à imagem da organização. Após essa análise, verificou-se que as metas possuem um importante papel no aumento do desempenho da organização, todavia, deve-se ter certo cuidado na sua utilização, pois elas podem levar as pessoas a comportamentos não éticos, à inibição da cooperação e do aprendizado organizacional, entre outros.

  14. Hallazgo de dos nidos activos de Phytotoma raimondii, Tackzanowski, 1883, cortarrama peruana

    OpenAIRE

    Mario Rosina; Mónica Romo

    2011-01-01

    Dos nidos de Phytotoma raimondii, cortarrama peruana, fueron hallados en la localidad de El Gramadal, distrito de Huarmey, Provincia de Huarmey, Departamento de Áncash. Ambos nidos estaban en arbustos de Grabowskia boerhaaviaefolia palo negro. Uno de ellos contenía dos huevos y el segundo dos pichones de unos diez días a dos semanas de edad. Una semana después, el 14 de abril de 2010 se ubicó muy cerca del segundo nido que ya estaba vacío, a dos volantones que seguían a sus padres. ...

  15. As expectativas dos pais em relação às aulas de instrumento

    OpenAIRE

    Silva, Luís António Teixeira de Lima e

    2015-01-01

    Esta investigação discute as expectativas dos pais dos alunos do ensino articulado de música em relação às aulas de instrumento dos seus filhos. Tomando por base a aparente importância dada pela literatura à relação pai/professor/aluno, esta pesquisa serve o propósito principal de entender as expectativas dos pais em relação às aulas de instrumento dos seus filhos para que o entendimento desta relação possa ser aprofundado. Foi desenvolvido um questionário com questões relac...

  16. Santa sexualidad: concepciones de dos monjas sobre feminidad y sexualidad

    OpenAIRE

    Isabel Cristina Giraldo Quijano

    2009-01-01

    En el contexto de la religión católica, la feminidad y la sexualidad femenina se configuran según dogmas y representaciones sociales específicos, en los que la imagen de Cristo -y todo lo que ello implica- actúa como elemento fundamental en la construcción de las concepciones de las mujeres consagradas a la vida religiosa sobre sex ualidad, erotismo, cuerpo. amor. Este artículo pretende explorar desde un punto de vista sociológico las concepciones de dos monjas sobre los temas mencionados....

  17. Mercosur post elecciones: posibles escenarios dos paradigmas en disputa

    OpenAIRE

    Lagarde Munin, Oscar Andrés; Mucciaccia, Facundo

    2014-01-01

    Al analizar la historia del Mercosur, se observan claramente dos fases bien diferenciadas. En la primera década (años 90) el proceso estuvo fuertemente influenciado por el llamado regionalismo abierto, siguiendo una lógica estrictamente comercial propia de la hegemonía neoclásica de entonces; mientras que en la segunda década se produjo un cambio de paradigma, traducido en una mayor intervención del Estado como rector del proceso de integración y la consecuente modificación de las agendas, e...

  18. A natural product based DOS library of hybrid systems.

    Science.gov (United States)

    Prabhu, Ganesh; Agarwal, Shalini; Sharma, Vijeta; Madurkar, Sanjay M; Munshi, Parthapratim; Singh, Shailja; Sen, Subhabrata

    2015-05-01

    Here we described a natural product inspired modular DOS strategy for the synthesis of a library of hybrid systems that are structurally and stereochemically disparate. The main scaffold is a pyrroloisoquinoline motif, that is synthesized from tandem Pictet-Spengler lactamization. The structural diversity is generated via "privileged scaffolds" that are attached at the appropriate site of the motif. Screening of the library compounds for their antiplasmodial activity against chloroquine sensitive 3D7 cells indicated few compounds with moderate activity (20-50 μM). A systematic comparison of structural intricacy between the library members and a natural product dataset obtained from ZINC(®) revealed comparable complexity. PMID:25794788

  19. Efeito dos incêndios florestais na qualidade do ar

    OpenAIRE

    Miranda, Ana Isabel

    1998-01-01

    Os incêndios florestais podem ser considerados como um processo de combustão natural em grande escala, que consome diversas espécies vegetais numa área geográfica específica Consequentemente, consistem numa fonte potencial de elevadas quantidades de poluentes para a atmosfera, sendo indispensável conhecer o seu impacto na qualidade do ar. O objectivo principal deste trabalho consiste no estudo do efeito das emissões dos incêndios florestais na qualidade do ar. Para tal, foram d...

  20. Preventive conservation applied to "Casa dos Patudos" oil painting collection

    Directory of Open Access Journals (Sweden)

    Mafalda Fernandes

    2016-01-01

    Full Text Available The main objective of this work was the identification of specific risks affecting the collection of oil paintings in the historic house "Casa dos Patudos" (Alpiarça, Portugal and the development of mitigation strategies for the risks encountered. The methodology used was proposed by the Canadian Conservation Institute. The results showed that the main risks affecting this collection result from incorrect handling, increase in paint detachment due to the maintenance of paintings with paint lifting on display, occurrence of insect pests, high fluctuations in relative humidity and, excessive exposure to ultraviolet radiation. Several preventive conservation strategies to mitigate these risks are proposed.