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Sample records for avaliacao dos tumores

  1. Magnetic resonance imaging textural evaluation of posterior cranial fossa tumors in childhood; Avaliacao textural por ressonancia magnetica dos tumores da fossa posterior em criancas

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    Santos, Joelson Alves dos; Costa, Maria Olivia Rodrigues da; Otaduy, Maria Concepcion Garcia; Lacerda, Maria Teresa Carvalho de; Leite, Claudia da Costa [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Dept. de Radiologia]. E-mail: joelson_alves@ig.com.br; Matsushita, Hamilton [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Dept. de Neurologia

    2004-08-01

    Objective: To distinguish healthy from pathological tissues in pediatric patients with posterior cranial fossa tumors using calculated textural parameters from magnetic resonance images. Materials And Methods: We evaluated 14 pediatric patients with posterior cranial fossa tumors using the software MaZda to define the texture parameters in selected regions of interest representing healthy and pathological tissues based on T2-weighted magnetic resonance images. Results: There was a statistically significant difference between normal and tumoral tissues as well as between supposedly normal tissues adjacent and distant from the tumoral lesion. Conclusion: Magnetic resonance textural evaluation is an useful tool for determining differences among various tissues, including tissues that appear apparently normal on visual analysis. (author)

  2. Computed tomography evaluation of mast cell tumours; Avaliacao por tomografia computadorizada dos mastocitomas

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    Lorigados, Carla Aparecida Batista; Matera, Julia Maria; Macedo, Thais; Pinto, Ana Carolina Brandao Fonseca, E-mail: clorigados@usp.br [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia. Dept. de Cirurgia

    2012-07-01

    The mast cell tumours are common tumours of the canine skin. Computed tomography (CT) has assumed an important role in tumours evaluation and staging. The aim of this study was to evaluate the role of CT as a method of assessing characteristics of mast cell tumors. Ten dogs with mast cell tumor were evaluated. CT was performed before and after the intravenous injection of hydro soluble ionic iodine. Attenuation, contrast enhancement, cleavage with adjacent tissues and the unidimensional measurement of each lesion was determined in it maximum diameter, in transversal plane. Concerning the attenuation characteristic, 50% were homogeneous and 50% heterogeneous. The contrast enhancement was homogeneous in 50% of cases, heterogeneous in 40% and peripheral in 10%. Fifty percent of the tumours showed loss of plane of cleavage and 30% partial loss. This information can help in directing the patients that will be undergoing chemotherapy or surgery. (author)

  3. Fatores prognósticos no tratamento dos tumores intramedulares

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    Koerbel Andrei

    2002-01-01

    Full Text Available Entre 1993 e 1999, foram analisados 35 pacientes submetidos a microcirurgia para remoção de tumor intramedular nos Serviços de Neurocirurgia do Hospital Nossa Senhora das Graças e do Hospital de Clínicas de Curitiba - PR. A população foi composta por 68,6% de pacientes do sexo masculino; a média de idade era de 32,9 anos. A localização tumoral mais frequente foi torácica em 40% dos casos, seguida pela região cervical e cervicotorácica em 25,7%. Ao exame neurológico realizado entre 6 a 12 meses do pós-operatório, 42,9% dos pacientes demonstraram melhora, 34,3% permaneceram estáveis e 22,9% dos casos apresentaram piora. A ressecção foi total em 57,2% dos casos e subtotal em 37,1%. Em 5,7% dos pacientes, foi realizada apenas biópsia para diagnóstico. O grau de ressecção completa foi maior nos ependimomas (13 de 17 casos e menor nos astrocitomas (5 de 12 casos. Entretanto, o grau de ressecção e o tipo histológico não interferiram na morbidade pós-operatória. Fatores como sexo, idade e tamanho do tumor também não demonstraram importância na evolução após a cirurgia. A localização torácica do tumor foi associada a maior morbidade cirúrgica (p=0,021.

  4. Evaluation of effects of ionizing radiation on materials used in dental restorations;Avaliacao dos efeitos da radiacao ionizante em materiais utilizados em restauracoes dentarias

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    Maio, Mireia Florencio

    2009-07-01

    This work consisted of quantitative studies of the effects caused by ionizing radiation on materials used in dental restorations (Titanium, Amalgam, Resin Composite and Glass Ionomer) aiming the deleterious effects of radiotherapy when patients with tumors in head and neck, arising when the teeth are restored within in the field of radiation. Samples were submitted to X-ray beams of 6 MV from a linear accelerator, VARIAN 2100C model. The samples were analyzed by X-ray fluorescence techniques to compare the chemical composition before and after the irradiation. The sample were submitted to Geiger-Mueller detectors and the ionization chambers in order to verify any residual radiation in the samples. The samples were also analyzed by gamma spectrometry by a Germanium detector. These tests were performed to determine small changes in the composition in the samples due to the radiation interaction. The results of this study may encourage the development of new research for alternative materials in dental restorations that can contribute to improve the quality of life of those patients with tumors of the mouth. (author)

  5. Current diagnostic approach of bone tumors in childhood; Abordagem diagnostica atual dos tumores osseos na infancia

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    Torre, Marcia Barbosa; Scatigno Neto, Andre [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina. Hospital das Clinicas

    1995-09-01

    The authors analyze the magnetic resonance imaging (MRI) as the imaging modality of choice for evaluation of patients with bone tumors or soft tissue tumors. The advent of such a sensitive imaging modality is fortuitous and coincides with a recent change in the therapeutic approach to primary bone tumors. MRI is extremely valuable in monitoring the tumor response to the initial chemotherapy and is accurate defining the margins of tumor, facilitating planning of limb salvage surgical procedures. (author). 5 refs., 8 figs.

  6. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas

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    Zuccari D.A.P.C.; Santana A.E.; Rocha N.S.

    2002-01-01

    Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transform...

  7. Diagnosis and evaluation of surveying examination by intracranial tumor in dogs CT; Diagnostico e avaliacao topografica de neoplasias intracranianas pelo exame de TC em caes

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    Romaldini, Andre Fonseca; Santos, Debora Rodrigues dos; Oliveira, Juliana Messias; Abreu, Felipe Andrei Suarez; Wallace, Verena; Pacheco, Eduardo Nelson da Silva, E-mail: andreromaldini@gmail.com [Hospital Santa Ines de Sao Paulo, Santana, SP (Brazil)

    2012-07-01

    The use of computed tomography (CT) revolutionized image diagnostic in veterinary medicine and currently can be considered one of the most useful tools for the imaging evaluation of intracranial tumor in dogs. Computed tomography of the brain in small animals allows visualization of intracranial tumor, compression of adjacent structures such as cerebral parenchyma, falx or lateral ventricles, and evaluate secondary hemorrhages and edema. The CT imaging provides essential information to indicate the surgical approach for a possible tumor resection or biopsy, including the correct location and boundaries structures involved, and also can be used to monitor the clinical treatment. However, only histopathological examination is able to confirm the final diagnosis. (author)

  8. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas

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    Zuccari D.A.P.C.

    2002-01-01

    Full Text Available Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transformação celular maligna. A alfa-actina e a vimentina mostraram-se eficientes na marcação de células mioepiteliais. A alfa-actina diminuiu a marcação na metaplasia óssea ou cartilaginosa contrariamente à vimentina cuja marcação foi aumentada. Os resultados permitem melhor entendimento da classificação dos tumores mamários de cadelas com a utilização de anticorpos monoclonais como marcadores do citoesqueleto, que se mostraram eficientes nessa caracterização.

  9. Computed tomography of mast cell tumors in dogs: assessment before and after chemotherapy; Tomografia computadorizada de mastocitomas em caes: avaliacao pre e pos-tratamento quimioterapico

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    Lorigados, Carla A.B.; Matera, Julia Maria; Pinto, Ana Carolina B.C.F.; Macedo, Thais R., E-mail: clorigados@usp.br [Universidade de Sao Paulo (FMVZ/USP), SP (Brazil). Fac. de Medicina Veterinaria e Zootecnia. Dept. de Cirurgia; Coppi, Antonio A.; Ladd, Fernando V.L. [Universidade de Sao Paulo (LSSCA/USP), SP (Brazil). Fac. de Medicina Veterinaria e Zootecnia. Lab. de Estereologia Estocastica e Anatomia Quimica; Souza, Vanessa A.F. de [Faculdades Metropolitanas Unidas (FMU), Sao Paulo, SP (Brazil). Curso de Medicina Veterinaria

    2013-11-15

    Nineteen dogs with mast cell tumors treated with chemotherapy were evaluated by computed tomography (CT). Were evaluated aspects related to contours, attenuation, postcontrast enhancement and presence of cleavage with adjacent structures. The RECIST criteria and volumetric measurement of lesions were performed to assess the response to treatment. The mast cell tumors presented a homogeneous or heterogeneous attenuation, presented more frequently a well delineated and regular contours and moderate enhancement after intravenous administration of the iodinated contrast media. The methods RECIST and volumetric measurements showed an excellent agreement to the classification of therapeutic response, providing a good parameter of the response to treatment. The CT examination proved to be useful in the delimitation of the tumor and an important tool for planning of surgical margins. (author)

  10. O líqüido cefalorraqueano iso diagnóstico dos tumores intracranianos

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    Aloysio Mattos Pimenta

    1954-09-01

    Full Text Available Foi feito um estudo do líqüido cefalorraqueano num material de 180 casos de tumores intracranianos, histològicamente verificados, apreciando-se a possibilidade de sugestões diagnósticas, em relação à sede, natureza e aspectos cirúrgico e clínico. Foi utilizada a via cisternal para a obtenção do líquor, sendo que a punção negativa da cisterna constituiu um elemento de suspeita diagnostica nos tumores da fossa posterior e de indicação de cautela ao médico que a pratica. As vantagens da via cisternal para colheita do liquor foram assinaladas. A pressão inicial foi normal em 35% dos casos, diminuída em 7% e aumentada em 58%. A hipotensão apareceu em 5 hematomas, num total de 14 casos considerados. Não houve grande diferença de freqüência de hipertensão entre tumores infra e supratentoriais. Em relação à natureza do tumor, o glioblastoma e o abscesso - processos de crescimento rápido - tiveram maior tendência a apresentar hipertensão, em relativa oposição àqueles de crescimento lento (astrocitoma e meningeoma. Houve concordância absoluta entre os sinais clínicos de hipertensão - tríade hipertensiva completa - e a hipertensão do líquor. Entretanto, nos casos com tríade incompleta, foram verificadas, freqüentes vêzes, valores normais da pressão e mesmo hipotensão. O quociente raqueano de Ayala, nos casos de líquor hipertenso, evidenciou em grande maioria o tipo tumoral (menor que 5. 0 valor da fórmula QR menor que 5 e QRD maior que 3, não foi comprovado em nosso material. A xantocromia foi dominante nos casos de hematoma. O crescimento rápido pareceu influir mais que a natureza específica no aparecimento da xantocromia. O retículo fibrinoso foi notado em 20 casos, dos quais 2 sem taxa elevada de proteínas, aparecendo com maior freqüência nos casos de abscesso e glioblastoma. O líquor hemorrágico sòmente foi observado nos casos de hematoma. A citologia quantitativa não forneceu dados que

  11. Expressão dos filamentos intermediários no diagnóstico dos tumores mamários de cadelas Expression of intermediate filaments in canine mammary tumors diagnosis

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    D.A.P.C. Zuccari; Santana, A. E.; N.S. Rocha

    2002-01-01

    Foram utilizados anticorpos monoclonais para marcação imunoistoquímica dos tecidos tumorais e obtenção de informações sobre a histogênese dos tumores mamários utilizando-se anti-citoqueratinas para marcação de células epiteliais, e anti-actina e anti-vimentina para células mioepiteliais. O procedimento imunoistoquímico mostrou-se esclarecedor com relação à histogênese dos tumores mamários, confirmando a marcação de células epiteliais com as citoqueratinas que perdem sua expressão na transform...

  12. Evaluation of effects of ionizing radiation on the glass ionomer used in dental restorations;Avaliacao dos efeitos da radiacao ionizante no ionomero de vidro utilizado em restauracoes dentarias

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    Maio, F.M.; Santos, A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Fernandes, M.A.R. [UNESP, Botucatu, SP (Brazil). Faculdade de Medicina

    2009-07-01

    The purpose of this work consisted of quantitative studies of the effects caused by ionizing radiation on glass ionomer, a material used in dental restorations. Glass ionomer is used to mitigate the deleterious effects of radiotherapy when patients with tumors in head and neck, seen when the teeth are restored within in the field of radiation. Samples were submitted to X-radiation beams from 6 MV from a linear accelerator, VARIAN 2100C model. The samples were analyzed by X-ray fluorescence techniques to compare the chemical composition before and after the irradiation. Sample dose measurements were performed employing Geiger-Mueller detectors and the ionization chamber in order to verify any residual radiation in the samples. The samples were also analyzed by gamma spectrometry by a HPGe detector. These tests were performed to determine small changes in the composition in the samples due to the radiation interaction. The results of this study may encourage the development of new research for alternative materials in dental restorations that can contribute to improve the quality of life of those patients with tumors of the mouth. (author)

  13. Análise dos últimos 50 casos de tumor de células gigantes ósseo tratados na unidade de tumores do aparelho locomotor dos Hospitais da Universidade de Coimbra

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    Lemos, António Carlos de Almeida Rodrigues de

    2009-01-01

    Introdução e Objectivo: O tumor de células gigantes ósseo constitui 5% dos tumores ósseos primários, podendo atingir os 20% na Ásia. A sua histologia, clínica e epidemiologia são conhecidas e encontram-se bem retratadas na literatura científica actual. O seu comportamento biológico imprevisível torna-o um desafio na obtenção de bons resultados com a preconização da terapêutica cirúrgica. O objectivo deste estudo foi investigar as características epidemiológicas, distribuição esquelética, méto...

  14. The use of dynamic computation systems in the evaluation of the damages caused by oil spill; O uso de sistemas computacionais dinamicos na avaliacao dos danos causados por derrames de petroleo

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    Barbosa, Luiz H.C.; Laurino, Luiz S.; Muelbert, Jose H. [Fundacao Universidade Federal do Rio Grande (FURG), RS (Brazil)

    2004-07-01

    Estuarine areas are zones of great environmental risk characterized as great sensitivity to oil and oil products spills. Traditionally, Geographic Information Systems (GIS) are used to evaluate these possible impacts. However, for some groups of organisms, like plankton, the spatial limitations of GIS become inadequate because their distributions exhibits temporal variability and are associated with dynamic environmental factors. Having this in mind, the development of a specific tool is necessary to supply this need. For the development of this tool, data of fish larvae and eggs (ichthyoplankton) from the Lagoa dos Patos Estuary (RS) were chosen as an initial group for the development of a Plankton Diagnostic System (SIDIPLA). These groups have an accentuated sensitivity to oil spills. This impact could directly affect the environment quality and indirectly the local fishing resource. SIDIPLA is elaborated from data reports covering every estuarine area and graphs are generated containing abundance of the species of fish larvae and eggs from the geographical position, season, temperature and salinity; selected by the user from an Internet page (http://corvina.lei.furg.br/sidipla). Several simulations demonstrated the strength of the system and its easy use. Furthermore this tool can be implemented in different places of the Brazilian coast and different groups of organisms. (author)

  15. Radiation therapy for glomus tumors of the temporal bone; Tratamento radioterapico dos tumores glomicos do osso temporal

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    Dall' Igna, Celso; Antunes, Marcelo B. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Hospital das Clinicas. Servico de Otorrinolaringologia e Cirurgia da Cabeca e Pescoco; Dall' Igna, Daniela Pernigotti [Parana Univ., Curitiba, PR (Brazil)

    2005-11-15

    The treatment of glomic tumors has been controversial since its first description. It can be done with surgery, radiotherapy or just expectation. Aim: the objective of this paper was to evaluate the effectiveness and complications of radiotherapy.Study Design: clinical with transversal cohort. Material and method: it was made a retrospective review in the charts of the patients with glomus jugular tumors treated with radiotherapy. Disease control was determined by (1) no progression of symptoms or cranial nerve dysfunction or (2) no progression of the lesion in radiological follow-up. It was also evaluated the follow-up period and the sequelae of the treatment. Results: twelve patients were included, 8 of then women. The follow-up period was from 3 to 35 years, with a media of 11,6 years. The main symptoms were: hearing loss, pulsate tinnitus, dizziness and vertigo. The signs were pulsate retrotympanic mass, facial palsy and cofosis. The tumors were staged using Fischs classification. The radiotherapy was performed with linear accelerator with dose ranging from 4500-5500 in 4-6 weeks. In the follow-up period were possible to identify sequelaes like dermatitis, meatal stenosis, cofosis and facial palsy. Discussion: the signs and symptoms were the same found in the medical literature. The type and dosages of the radiotherapy were also the same of others reports. All patients had improvement of the symptoms and only one was not considered as having disease controlled. Complications were, in general, minor complications, with exception of the cofosis and facial palsy. Conclusion: radiotherapy is a viable alternative to treatment of these tumors because their good response and low level of complications. It should be considered specially in advanced tumors where a surgical procedure could bring a high level of morbidity. (author)

  16. Indicação e tratamento dos tumores benignos do fígado Indication and treatment of benign hepatic tumors

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    Júlio Cezar Uili Coelho

    2011-12-01

    Full Text Available INTRODUÇÃO: Os tumores hepáticos benignos ocorrem em 9% da população. A grande maioria dessas neoplasias é diagnosticada em pacientes assintomáticos durante a realização de exames de imagem de rotina. OBJETIVO: Apresentar os principais aspectos das indicações e tratamento dos tumores hepáticos benignos. MÉTODOS: Foi realizada revisão de literatura baseada em pesquisa no PubMed, Bireme e Scielo cruzando os descritores neoplasia hepática, hemangioma, adenoma e hiperplasia nodular focal. Foram selecionados, estudos de técnicas cirúrgicas e acrescentada a experiência dos autores. O hemangioma é o tumor hepático mais comum, sendo identificado entre 5% e 7% das necropsias. É mais comum nas mulheres entre as 3ª e 5ª décadas da vida e pode aumentar de tamanho na gravidez e com a administração de estrogênios. Apesar de não estabelecida, a sua causa está relacionada com os hormônios sexuais. As complicações incluem inflamação, coagulopatia, sangramento e compressão de estruturas vizinhas. Rotura espontânea é excepcional, com somente 35 casos descritos na literatura internacional. O adenoma e a hiperplasia nodular focal predominam no sexo feminino e na faixa etária de 20 a 40 anos. Enquanto o primeiro requer ressecção hepática pelo risco de sangramento e malignização, o segundo deve ter conduta expectante. CONCLUSÕES: Os tumores hepáticos benignos mais comuns são em ordem decrescente de frequência o hemangioma, hiperplasia nodular focal e o adenoma. A diferenciação entre tumores benignos e malignos é geralmente realizada com segurança com base nos dados clínicos e nos exames de imagem. O hemangioma e a hiperplasia nodular focal geralmente tem conduta expectante, enquanto que o adenoma requer ressecção pelo risco de hemorragia e de transformação em carcinoma.BACKGROUND: Benign hepatic tumors occur in 9% of the population. The majority is diagnosed in asymptomatic patients during routine imaging exams

  17. Comparação dos métodos de imagem no diagnóstico dos tumores renais e calcificações nestas neoplasias Comparison of imaging methods for diagnosis of renal tumors and their calcifications

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    Sergio Marrone Ribeiro

    2004-12-01

    Full Text Available OBJETIVO: Tentar estabelecer uma metodologia no diagnóstico e conduta dos pacientes com massas renais sólidas e complexas, comparando os custos e benefícios dos diferentes métodos de diagnóstico por imagem. Procuramos avançar no diagnóstico diferencial entre lesões benignas e malignas, particularmente através da investigação das calcificações tumorais. MÉTODOS: Realizamos um estudo prospectivo em 31 pacientes portadores de massas renais sólidas ou complexas, todos eles submetidos à ultra-sonografia abdominal (US, ultra-sonografia doppler da massa renal (US Dop, tomografia computadorizada (TC e ressonância magnética (RM. RESULTADOS: Encontramos 28 pacientes com massas malignas e três com massas benignas. Entre os 28 pacientes com lesões malignas, 17 mostraram calcificações pela TC; 16 deles calcificações do tipo central e um calcificação do tipo curvilinear periférica pura (casca de ovo. A urografia excretora (UGE mostrou uma taxa de detecção para calcificações significantemente menor que a US e a TC. Massas benignas e malignas apareceram como descrito na literatura, com o US, TC e RM mostrando alta sensibilidade e especificidade no diagnóstico dos tumores renais. A exceção foi na US Dop, onde nós obtivemos menor sensibilidade para a caracterização de fluxo tumoral maligno. CONCLUSÕES: Foi surpreendente verificar que a TC revelou calcificações centrais em 51,6% dos pacientes desta série, todas elas em lesões malignas, quando a literatura refere uma freqüência de calcificações entre 8% e 22% dos carcinomas de células renais, em estudos utilizando radiografias simples do abdômen e UGE. Este achado é de grande importância quando consideramos que estas calcificações ocorrem particularmente em neoplasias malignas. Como resultado da comparação dos diferentes métodos de diagnóstico por imagem, nós propomos uma metodologia para adequada investigação dos tumores renais.BACKGROUND: To establish the

  18. Tratamento radioterápico dos tumores glômicos do osso temporal Radiation therapy for glomus tumors of the temporal bone

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    Celso Dall'Igna

    2005-12-01

    Full Text Available O tratamento dos tumores glômicos tem sido motivo de controvérsia desde sua primeira publicação, podendo ser cirúrgico, radioterápico ou apenas expectante. OBJETIVO: O objetivo do estudo foi avaliar a efetividade e as complicações do tratamento radioterápico para esses tumores. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Trata-se de uma coorte histórica de pacientes com tumor glômico jugular submetidos à radioterapia. Os critérios de controle da doença foram não haver progressão dos sintomas ou disfunção de nervos cranianos, sem aumento do tamanho da lesão ao exame físico ou controle radiológico. Avaliamos também a presença de seqüelas do tratamento. RESULTADOS: Foram incluídos 12 pacientes, sendo oito mulheres. O tempo de follow-up variou de 3 a 35 anos, com uma media de 11,6 anos. Os principais sintomas foram: hipoacusia, zumbido pulsátil e tontura ou vertigem. Os achados de exame físico mais freqüentes foram massa pulsátil retrotimpanica, paralisia facial e anacusia, sendo os tumores estadiados segundo a classificação proposta por Fisch. A radioterapia foi realizada com acelerador linear com doses variando de 4500-5500 Rads por 4-6 semanas. As seqüelas mais comuns foram a dermatite, estenose do conduto auditivo externo, anacusia e paralisia facial. DISCUSSÃO: Os sintomas e achados de exame físico e o método e dosagem da radioterapia não diferiram daqueles encontrados na literatura. Todos os pacientes tiveram melhora dos sintomas e apenas um não foi considerado como tendo controle da doença. As complicações do tratamento foram de pouca repercussão, com exceção da anacusia e da paralisia facial. CONCLUSÃO: A radioterapia é uma alternativa viável para o tratamento desses tumores pela boa resposta e baixo índice de complicações. Deve ser considerada especialmente em tumores mais avançados onde um procedimento cirúrgico pode trazer grande morbidade.The treatment of glomic

  19. Tumores das células da granulosa dos ovários: estudo de 24 casos Granulosa cell tumors of the ovary: a study of 24 cases

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    Artur Lício Rocha Bezerra

    2004-09-01

    Full Text Available OBJETIVOS: avaliar estadiamento, procedimentos cirúrgicos e evolução dos tumores das células da granulosa (TCG dos ovários, dando ênfase à possibilidade de cirurgia conservadora (ooforectomia unilateral. MÉTODOS: este é um estudo de coorte retrospectivo no qual foram incluídas 24 pacientes com TCG tratadas no período de janeiro de 1994 a janeiro de 2004. Foram analisadas variáveis de interesse, tais como idade da paciente, sintomatologia, tamanho tumoral ao exame físico, estadiamento, modalidades de tratamento (tipos de cirurgia e adjuvância com quimioterapia e/ou radioterapia e prognóstico. As associações entre as variáveis foram avaliadas pelo teste do chi-quadrado e para significância estatística considerou-se p OBJECTIVE: to evaluate staging, surgical procedures and outcome of ovarian granulosa cell tumors (GCT, with emphasis in the possibility of conservative surgery (unilateral ooforectomy. METHODS: this is a retrospective cohort study in which 24 patients treated with GCT during the period of January 1994 to January 2004 were included. Variables of interest such as patient's age, symptoms, tumor size on physical examination, staging, treatment modalities (types of surgery and of adjuvant chemotherapy and/or radiotherapy and prognosis have been analyzed. The chi-square test was used to check the association between variables, and the level of significance was set at p < 0.05, always describing the two-tailed Fisher exact test. RESULTS: the patients' age varied from 30 to 82 (mean 51.7 years old. The most frequently referred symptom was pelvic pain (n = 10; 41.7%. Fourteen patients (58.3% presented clinical stage (CS Ic, 5 (20.8% CS IIIc and 5 (20.8% CS Ia. More advanced clinical stages were significantly associated with palpable pelvic masses (p < 0.04. Endometrial hyperplasias were found in 3 (25% of the 12 hysterectomy specimens. The follow-up period varied from 2 to 114 (mean 42.5 months. Among the 16 (66

  20. Imaging diagnosis of neoplasms of the oropharynx; Diagnostico por imagem dos tumores da orofaringe

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    Souza, Ricardo Pires de [Complexo Hospitalar Heliopolis (HOSPHEL), Sao Paulo, SP (Brazil). Servico de Radiologia; Yamashiro, Ilka; Gonzalez, Fabio Mota; Tornin, Olger; Botelho, Renato Assayag; Paes Junior, Ademar Jose de Oliveira [Complexo Hospitalar Heliopolis (HOSPHEL), Sao Paulo, SP (Brazil)]. E-mail: ilkay@terra.com.br

    2005-04-15

    The oropharynx extends from the base of the tongue (circumvallate papilla) to the upper border of the epiglottis and includes the palatine tonsils, soft palate and their muscles. Horizontal lines passing through the hard palate and hyoid bone constitute the superior and inferior limits, respectively. It is bounded anteriorly by the oral cavity and posteriorly by mucosa at the level of the second and third cervical vertebrae. The lateral walls are formed by two arches: the palatoglossus (anteriorly) and the palatopharyngeal (posteriorly) muscles. Staging of the neoplasms of the oropharynx is based on the size of the tumor and on the involvement of adjacent and distant structures. Therefore, the use of imaging methods, particularly computerized tomography and magnet resonance is essential for the assessment of deep extension of these lesions, including areas of difficult evaluation on clinical examination. (author)

  1. Study of crotoxin mechanism of action to mammary carcinomas and evaluation of its potential as a radiopharmaceutical; Estudo do mecanismo de acao da crotoxina em tumores mamarios e avaliacao do seu potenctial radiofarmaceutico

    Energy Technology Data Exchange (ETDEWEB)

    Silveira, Marina Bicalho

    2010-07-01

    Crotoxin, the main component of Crotalus durissus terrificus snake venom, has been studied since 1938. It is a natural polypeptidic complex with pharmacological potential because of its antitumoral properties which has attracted great interest for diagnosis and therapy of oncological diseases. However, Crotoxin mechanism of action and sites of specific interaction on tumor cells are still misunderstood. Breast cancer is the second most frequent type in the world and the most common cancer in women. About 30 to 60% of mammary tumors overexpress epidermal growth factor receptor (EGFR), a transmembrane protein related to cell proliferation. Since literature has reported that Crotoxin antitumoral effect is more potent on cells with EGFR overexpression the objectives of this work were to evaluate Crotoxin cytotoxic effects on mammary tumor cells human breast carcinoma (MCF-7) and Ehrlich tumor cells (murine ascitics carcinoma), and to investigate the specific molecular interaction of Crotoxin on Ehrlich tumor cells. Initially, Crotoxin was radiolabelled with iodine-125 ({sup 125}I-Crotoxin) and iodine-131 ({sup 131}I-Crotoxin). Saturation and competition assay were carried out to characterize Crotoxin in vitro interaction; Crotoxin biodistribution studies and singlephoton emission computed tomography (SPECT) of mice bearing Ehrlich tumor have been evaluated to describe in vivo interaction. Our results showed that Crotoxin presented cytotoxic effect against Ehrlich with DL{sub 50} in vitro (concentration of compound which is lethal for 50% of cells) of about one micromolar, but did not present significant effect against MCF-7. Morphological alterations characteristic of apoptosis suggests programmed cell death. {sup 125}I-Crotoxin interaction with Ehrlich tumor cells was saturable with approximately 70% specificity, and presented K{sub d}=24.98 nmol/L and B{sub max}=16,570 sites/cell for low affinity binding sites and K{sub d}=0.06 nmol/L and B{sub max}=210 sites

  2. Evaluation of parapharyngeal space by computerized tomography and magnetic resonance. Part 2: tumours and pseudo tumours; O valor da tomografia computadorizada e da ressonancia magnetica na avaliacao do espaco parafaringeo. Parte 2: tumores e pseudotumores

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Ricardo Pires de; Rapoport, Abrao [Hospital Heliopolis, Sao Paulo, SP (Brazil)

    1994-01-01

    The tumors of the parapharyngeal space are a heterogeneous group of lesions not actually originating in the parapharyngeal space itself, fascially defined, but usually in the adjacent spaces, the mucosal pharyngeal space, masticatory space and carotid space. Centrally localized in the supra-hyoid neck, the parapharyngeal space can be used as a diagnostic key in the compartmental localization of these regional lesions, since one observes the pattern of dislocation of the fat content of the space by the lesions at computerized tomography or magnetic resonance. The authors reported 14 cases of parapharyngeal tumors analysed using this criteria, leading to 86% of correct compartmental localization. (author) 155 refs., 13 figs., 2 tabs.

  3. Setorectomia posterior direita laparoscópica no tratamento dos tumores hepáticos Laparoscopic right posterior sectioniectomy for treating hepatic tumors

    Directory of Open Access Journals (Sweden)

    Sergio Renato Pais Costa

    2010-12-01

    Full Text Available INTRODUÇÃO: A ressecção de neoplasias no setor posterior direito costuma ser um desafio técnico pela dificuldade de sua abordagem. Adicionalmente, as hepatectomias laparoscópicas tem se tornado alternativa interessante em virtude de muitas vantagens (baixa morbidade, curto tempo de internação, retorno precoce as atividades laborais e bons resultados cosméticos. OBJETIVO: Relatar experiência em doentes submetidos à setorectomia posterior direita laparoscópica por uma única equipe. MÉTODOS: Cinco doentes foram operados entre novembro de 2008 a agosto de 2010. A idade variou de 21 a 63 anos com mediana de 43 anos. Foram quatro mulheres e um homem. A causa das neoplasias foi: adenoma (n=2, hepatocarcinoma (n=1 e metástases (n=2. A lesão foi solitária em três casos (60 %. A média do tamanho das lesões foi 3,3 cm (1,8-5. Foram analisados: tempo cirúrgico, sangramento operatório, morbimortalidade, tempo de internação e tempo de retorno à atividade habitual. RESULTADOS: A média de tempo cirúrgico foi de 160 minutos (90-260. A de sangramento intra-operatório foi de 200 ml (0-500. Nenhum doente foi transfundido. Não houve mortalidade e a morbidade foi nula. A mediana de internação foi de três dias (2-5. A mediana de retorno às atividades cotidianas foi de 12 dias (7-20. A mediana de seguimento foi de 13 meses (1-20. Não houve recidiva de lesão. CONCLUSÃO: A setorectomia posterior direita laparoscópica representa boa opção tática para o tratamento dos tumores hepáticos situados no setor posterior do lobo direito. É opção segura que evita grandes incisões com morbimortalidade. Também apresenta bom resultado cosmético e retorno precoce ao trabalho.BACKGROUND: Resection of neoplasms arising in the posterior right sector is usually a technical challenge due to approach difficulties. Additionally, laparoscopic hepatectomy has become an interesting alternative with several advantages (low morbidity, short hospital

  4. Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors; Avaliacao de algumas sequelas bucais pos-radioterapia em pacientes tratados de neoplasias de cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Rubira, Cassia Maria Fischer; Devides, Nadia Juliana; Ubeda, Liliane Torsani; Lauris, Jose Roberto; Rubira-Bullen, Izabel Regina Fischer; Damante, Jose Humberto [University of Sao Paulo, Bauru, SP (Brazil). School of Dentistry. Stomatology Dept.; Bortolucci Junior, Antonio Geraldo [Amaral Carvalho Hospital, Jau, SP (Brazil)]. E-mail: damante@fob.usp.br

    2007-07-01

    The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%), dysphagia (38%), and dysgeusia (30%). In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 ({+-} 0.714). Stimulated salivary flow increased with increasing postradiotherapy time (p < 0.05). The prevalence of mucositis was associated with higher radiation doses (p < 0.05), and the prevalence of atrophic candidiasis was related to a longer post-treatment period (p < 0.05). Two cases of recurrence of the primary tumor were detected during the study. The main effect of radiotherapy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow. (author)

  5. Comparação dos métodos de imagem no diagnóstico dos tumores renais e calcificações nestas neoplasias Comparison of imaging methods for diagnosis of renal tumors and their calcifications

    OpenAIRE

    Sergio Marrone Ribeiro; Sergio Aron Ajzen; José Carlos Souza Trindade

    2004-01-01

    OBJETIVO: Tentar estabelecer uma metodologia no diagnóstico e conduta dos pacientes com massas renais sólidas e complexas, comparando os custos e benefícios dos diferentes métodos de diagnóstico por imagem. Procuramos avançar no diagnóstico diferencial entre lesões benignas e malignas, particularmente através da investigação das calcificações tumorais. MÉTODOS: Realizamos um estudo prospectivo em 31 pacientes portadores de massas renais sólidas ou complexas, todos eles submetidos à ultra-sono...

  6. Identification of anti-tumoral effect of a polypeptide isolated from Scorpionfish Scorpaena plumieri venom and assessment of its potential use for tumor diagnosis; Identificacao do efeito antitumoral de um polipeptidio isolado da peconha do peixe-escorpiao Scorpaena plumieri e avaliacao do seu potencial uso no diagnostico de tumores

    Energy Technology Data Exchange (ETDEWEB)

    Soprani, Juliana

    2008-07-01

    Cancer has killed millions of people worldwide. Despite the increasing knowledge about the molecular basis of tumor development, few advances have been reached in clinical therapy and diagnoses, which shows the importance of new drugs development for therapeutic and diagnosis purpose. Venomous creatures have been studied as potential sources of pharmacological agents and physiological tools. A lot of work has been done about biological activity of terrestrial animals, but comparatively less research has been undertaken on venomous marine creature, particularly fish, which means that marine toxins represent a vast and unexplored source of novel molecules with therapeutical potential. In this work, the scorpion fish Scorpaena plumieri crude venom (SPB) and a gelatinolytic protease purified from this venom (SPGP) were evaluated for their applicability for in vivo tumor detection. In vitro results showed that both. SPB and SPGP, possess a powerful antitumor effects on p53-wild-type glioblastoma cells (LD{sub 50}= 3,9 {+-} 0,98{mu}g/mL and 8,00 x 10{sup -12} {+-} 2,94 x 10{sup -12}M, respectively) and Ehrlich ascites carcinoma cells (LD{sub 50}=14,05 {+-} 2,95 {mu}g/mL and 1,22 x 10{sup -11} {+-} 6,56 x 10{sup -12}M, respectively). P53 mutant glioblastoma cells were more resistant to both, SPB and SPGP treatment (LD{sub 50} > 125 {mu}g/mL and LD{sub 50} > 1,39 x 10{sup -9}M, respectively). The morphological changes observed in the cell lines treated with SPB and SPGP, and the data of DAPI staining, indicate that the antitumor effect of these substances occurs via apoptosis. Radioactive probes of SPB ([{sup 99m}Tc] SPB) and SPGP ([{sup 125}I] SPGP) with high specific activity and high radiochemical purity were synthesized. Data of biodistribution studies, performed by intravenous injections in Swiss mice bearing Ehrlich carcinoma cells, showed that SPB has poor uptake in tumor region. On the other hand, SPGP had a substantial uptake in tumor at ali analyzed times

  7. Lipomatous tumors of the uterus: review and description of two new cases; Tumores lipomatosos del utero. Revision y descripcion de dos nuevos casos

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, C.; Sanchez, F.; Zarca, M. A.; Calvo, M. [Complejo Hospitalario de Ciudad Real (Spain)

    1999-07-01

    Lipomatous tumors of the uterus constitute a range of uncommon, benign lesions, less than 20 cases of which have been reported in the radiological literature. They contain mature adipose tissues and include pure forms (lipomas) and mixed forms (fibrolipomas, lipoleiomyomas, etc). They must be differentiated from other fat-containing masses of the female pelvis that should be treated surgically, since the malignant transformation of these tumors is scarcely reported in recent literature. Thus, we consider a conservative approach involving ultrasonography or radiological follow-up to be sufficient and that surgery should be reserved for those cases in which there are symptoms or evidence of rapid growth. We present two new c cases of uterine lipomatous tumors studied by ultrasound and computed tomography and we review the most common aspects of these lesions as reported in the literature. (Author) 13 refs.

  8. Primary malignant tumors originating in intraabdominal testes. A report of two cases; Tumores malignos primarios originados en testiculos abdominales. A proposito de dos casos

    Energy Technology Data Exchange (ETDEWEB)

    Gallego, J. C.; Gonzalez, J. M.; Suarez, I.; Ruiz, A. [Hospital Arquitecto Marcide. Ferrol (Spain)

    1999-07-01

    The incidence of primary tumor is greater in undescended testes than in scrotum. They are usually detected as large masses. However, there are few reports describing the radiological features of these lesions. We present two cases (a seminoma and a nonseminoma) studied by ultrasound and computed tomography. The ultrasound studies show well defined, slightly echogenic masses. In addition, computed tomography reveals areas of necrosis and calcifications. (Author) 9 refs.

  9. Forma tumoral da esquistossomose mansoni cerebelar: relato de caso e medida dos granulomas The tumoral form of cerebellar schistosomiasis: case report and measure of granulomas

    OpenAIRE

    Pedro Raso; Alexandre Tafuri; Ney da Fonseca Lopes; Eduardo Rossi Monteiro; Wagner Luiz Tafuri

    2006-01-01

    Caso raro de forma tumoral da esquistossomose mansoni cerebelar diagnosticada pela biópsia, em um paciente de 15 anos, que apresentou sinais e sintomas neurológicos 60 dias antes da cirurgia. A tomografia computadorizada revelou lesão expansiva, hiperdensa, localizada no cerebelo, sugestiva de glioma. O exame histopatológico mostrou numerosos ovos de S. mansoni envolvidos por reação inflamatória granulomatosa na fase necrótico-exsudativa, confluentes, localizados principalmente na camada inte...

  10. Avaliacao neuropsicologica de idosos praticantes de capoeira

    Directory of Open Access Journals (Sweden)

    Diogo Miranda Petry

    2014-01-01

    Full Text Available INTRODUÇÃO: Este estudo procura contribuir com uma relação pouco explorada no meio acadêmico: capoeira, cognição e envelhecimento. Relacionando estudos sobre funções executivas e a capoeira, busca-se investigar a interligação desta arte e as funções executivas. Estas se referem a desempenhos de comportamentos complexos (memória de trabalho, flexibilidade mental, tomada de decisão e a memória léxico-semântica. OBJETIVO: Comparar o desempenho de funções executivas em idosas praticantes de capoeira e idosas não praticantes de exercício físico. MÉTODO: Estudo transversal que coletou as informações de cada participante apenas uma vez. Serão comparados dois grupos: 1 grupo de idosos praticantes de capoeira e 2 idosos que não fazem exercício físico. Para seleção e caracterização dos grupos utilizaram-se: questionário sociodemográfico, aspectos gerais de saúde e escala de hábitos de leitura e escrita, mini-exame de estado mental (MEEM e escala de depressão de Yesavage (GDS-30. Para avaliar o desempenho das funções executivas foi realizado o teste de trilhas e as tarefas de fluência verbal. Para análise estatística dos dados será utilizado o teste de Shapiro-Wilk para normatização dos dados. O teste de t de Student e o teste U de Mann Whitney serão usados para comparar duas médias de amostras independentes. Utilizou-se a improvisação, a ação, a tomada de decisão, o equilíbrio e as noções de espaço, tempo, ritmo, música, e a compreensão do jogo da capoeira como intervenção devido à possível utilização dos processos executivos nessa arte. RESULTADOS: Verificou-se que não houve diferença significativa nos testes realizados. Porém houve superioridade nos testes de fluência verbal e testes de trilha A e B, sendo maior em B no grupo de capoeira do que no grupo controle. CONCLUSÃO: A prática de capoeira tem uma tendência em contribuir para a melhora das funções executivas, embora os

  11. Preparation and assessment of [{sup 99m}Tc]technetium aquacarbonyl complexes with 1,2-diaminoethane-N-substituted ligands for tumor detection; Preparo e avaliacao de complexos de [{sup 99m}Tc]tecnecio aquacarbonil com ligantes 1,2-diaminoetano-N-substituidos para deteccao de tumores

    Energy Technology Data Exchange (ETDEWEB)

    Radin, Adriano

    2010-07-01

    Over least 15 years the complex [[{sup 99m}Tc](H{sub 2}0){sub 3}(CO){sub 3}]{sup +} has been used as an intermediary to obtain technetium radiopharmaceuticals for applications in cardiology, neurology and oncology. Two important characteristics of this molecule are: the facility for obtaining that compound from aqueous solutions and the easiness of substituting H{sub 2}O molecules by atoms of other ligand molecules. In this project we prepared new complexes [[{sup 99m}Tc](CMN{sup S001-3})(H{sub 2}O)(CO){sub 3}]{sup +}, where (CMNS001) = N-[(4-methoxy) benzyl]-1,2-diaminoethane, (CMNS003) = N,N'-bis-[(4-methoxy)benzyl]-1,2-diaminoethane, and assessed the uptake of these complexes in murine melanoma cancer cell B16F10 and breast cells MCF-7 and MDA-MD-231, and compared with [[{sup 99m}](MIBI){sub 6}]{sup +} uptake. In vitro uptake for both new technetium complex reached values close to 5%, for all cell lines, whereas the [[{sup 99m}Tc](MIBI){sub 6}]{sup +} uptake was close to 1 %. The assessment of subcellular distribution showed high accumulation of the new complex in the membrane fraction, for MDAMB-231, while for B16F10 accumulation occurred both in membrane and cytoplasm; the concentration of [[{sup 99m}Tc](MIBI){sub 6}]{sup +} was mainly in the cytoplasm portion. Biodistribution study in mice allowed to observe the capture of up to 1.6% of the administered dose per gram of tumor tissue for the complex [[{sup 99m}Tc](CMNS001)(H{sub 2}O)(CO){sub 3}]{sup +}, whereas other organs such as heart, lung and muscle, showed uptake of about 5.6%, 6.4% and 2%, respectively. The complexes in this work showed a high rate of uptake in vitro, but was not reproduced in vivo model, which can be related to low concentration of the complexes inside the cells and reduced vascularity of tumor tissue, with lower intake of complex through the blood system. (author)

  12. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    OpenAIRE

    Isabella Coimbra Wagner; Murilo José de Barros Guimarães; Lilian Karine Neves da Silva; Francisco Montenegro de Melo; Maria Tereza Cartaxo Muniz

    2007-01-01

    OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA), fragmento da citoqueratina 19 (CYFRA21-1) e antígeno glicosídico associado a tumor 15-3 (CA 15-3) em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi real...

  13. Characterization of the anti tumoral activity of the thiosemicarbazones derived from N(4)-methyl-tolyl-2acetylpyridine And 2-pyridinoformamide and its metal complex: evaluation of the radiopharmaceutical potential; Caracterizacao da atividade antitumoral das tiossemicarbazonas derivadas de N(4)-metil-toluil-2-acetilpiridina e 2-piridinoformamida e seus complexos metalicos: avaliacao do potencial radiofarmaceutico

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Paulo Roberto Ornelas da

    2008-07-01

    Thiosemicarbazones have attracted great pharmacological interest because of their biological properties, such as cytotoxic activity against multiple strains of human tumors. The most studied compounds are pyridine-based because of their resemblance to pyridoxal metabolites that attach to co-enzyme B{sub 6}-dependant enzymes. This work aimed the characterization of the anti tumoral effect of N(4)-methyl-tolyl-2-acetylpyridine and 2-pyridinoformamide-derived thiosemicarbazones and the development of a radiopharmaceutical based on a thiosemicarbazone metal complex for positron emission tomography. In the first phase of this study were synthesized twenty-one thiosemicarbazones, derived from N(4)methyl-2 acetylpyridine and 2-pyridine formamide, as well as their metal complexes (Sn, Ga and Cu). Their cytotoxic potential were evaluated against brain and breast tumor cells in vitro. Our results showed all of them presented powerful cytotoxic and antiproliferative activities against glioblastoma multiform and breast adenocarcinoma at very low concentrations (nanomolar range). Morphological alterations characteristic of apoptosis, such as cell shrinkage, chromatin condensation were observed. Copper chloride was used as control and has presented IC50 at millimolar range suggesting that copper complexation with thiosemicarbazone significantly increases (more than 1 million) the anti tumoral effect of this metal. Due to the potent anti tumoral activity of N(4)-methyl-tolyl-2-acetylpyridine derived thiosemicarbazones and the excellent properties of {sup 64}Cu (T{sub 1/2} = 12.7 hours, {beta}{sup +}, {beta}{sup -}, and EC decay), at the second part for this work it was developed a new imaging agent (radiopharmaceutical) for tumor detection by positron emission tomography (PET). The radiopharmaceuticals were produced in the nuclear reactor TRIGA-IPR-R1 from CDTN, via neutron capture reaction {sup 63}Cu (n,{gamma}) {sup 64}Cu, of the copper complex N(4)-ortho-toluyl-2

  14. Valor do esfregaço no diagnóstico per-operatório dos tumores provenientes de neurocirurgias Value of the smear in the rapid diagnosis of tumors removed in neurosurgeries

    Directory of Open Access Journals (Sweden)

    Leila Chimelli

    1993-06-01

    Full Text Available A técnica do esfregaço no diagnóstico per-operatório de tumores provenientes de neurocirurgias vem sendo utilizada em diversos centros de neuropatologia. Com o objetivo de testar esta técnica, examinamos 137 esfregaços e correlacionamos os aspectos cito e histológicos. Analisamos 12 astrocitomas, 4 astrocitomas anaplásicos, 26 glioblastomas, 7 oligodendrogliomas, 7 ependimomas, 5 meduloblastomas, 8 schwannomas, 17 meningiomas, 13 adenomas de hipófise, 20 metástases e 18 tumores diversos e entidades não neoplásicas. Os resultados mostraram porcentual de acerto de 91,2%, coincidente à literatura. O conhecimento da localização do tumor contribuiu para o acerto diagnóstico e o reconhecimento do tecido normal foi importante inclusive para orientar o neurocirurgião a localizar o tumor. Acreditamos que o esfregaço deva ser mais usado em nosso meio, não só pela simplicidade na sua realização mas também pela precisão diagnostica.The smear technique has been used for rapid diagnosis of tumors removed in neurosurgeries in many neuropathological centers. In order to> assess the diagnostic accuracy of this technique, we examined 137 smears and made a cytohistological correlation. Our cases include 12 astrocytomas, 4 anaplastic astrocytomas, 26 glioblastomas, 7 oligodendrogliomas, 5 medulloblastomas, 8 schwannomas, 17 meningiomas, 13 pituitary adenomas, 20 metastatic tumors and 18 assorted tumors and non neoplastic lesions. The correct diagnosis was made in 91.2% of the cases which coincides to the literature. The knowledge of the localization and the characteristic morphologic features of some tumors were important for the diagnosis. The ability to recognize normal nervous tissue in smears was important even to help the surgeon to reach the tumor. We believe that the use of smears should be encouraged in our country in view of the simplicity of its preparation and accuracy of results.

  15. Comprobación de la efectividad de dos esquemas terapéuticos en el tratamiento del Tumor de Sticker en perros

    Directory of Open Access Journals (Sweden)

    Ibrain Calero Herrera; Reginald Eustace Thomas, Juan Carlos; Rodríguez Fernández.

    2006-10-01

    Full Text Available RESUMENSe estudiaron 14 perros afectados detumoraciones en los genitales externos.En cada caso se realizó un estudio previodonde se elaboró una historia clínica yposteriormente se le tomaron muestras desangre con y sin anticoagulante para larealización de un hemograma y ladeterminación de las proteínas totales,además se tomó una muestra de tejidotumoral para su estudio histopatológico.Los animales se dividieron en 2 grupos,uno tratado al que se le administró Sulfatode Vincristina a razón 0.025mg/kg de pesocorporal endovenoso con una frecuenciasemanal y un grupo control que fuerontratados quirúrgicamente con ablacióntotal del tumor y su posterior cauterizacióncon el electrocauterio. En todos los casosse confirmó la presencia de Tumor deSticker, la mayor incidencia es a los 6años, el 78.57% de los animales sonhembras, el 14.28% mostraron metástasis,los animales de ambos grupos mostraronanemia, los mejores resultados seobtuvieron con la quimioterapiaobteniéndose la recuperación total de losanimales con 3 ó 4 tratamientos (66.7% y33.3% respectivamente, existió unaligera tendencia a elevarse el Hematocritoy la Hemoglobina y no hubo recidiva,mientras que en el grupo control sepresentó recidiva en el 20% de losanimales. Se concluyó que laquimioterapia es más efectiva en eltratamiento del Tumor de Sticker que elmétodo quirúrgico lográndose unagran efectividad del sulfato de Vincristinasin que repercuta desfavorablementesobre los parámetros hematológicos ysalud de los animales.

  16. Computed tomography in the analysis of calcification patterns in pediatric bone tumors of the hip: a new approach; Tomografia computadorizada na analise dos padroes de calcificacoes nos tumores osseos da bacia em pediatria: nova abordagem

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Gabriel Antonio de; Werlang, Henrique Zambenedetti; Bergoli, Pedro Martins [Hospital Universitario Cassiano Antonio de Morais/Hospital Infantil Nossa Senhora da Gloria, Vitoria, ES (Brazil). Centro de Diagnostico por Imagem]. E-mail: hzwerlang@gmail.com; Frechiani, Madalena; Oliveira, Fernao [Hospital Infantil Nossa Senhora da Gloria, Vitoria, ES (Brazil)

    2006-11-15

    Objective: In the pediatric group, the radiological diagnosis of bone tumors of the hip is difficult and presents some peculiarities, but reviewed literature does not approach this specific problem. The objective of the present study was to investigate the existence of reliable radiological patterns for the differential diagnosis of these tumors. Materials And Methods: Radiological findings of bone tumors of the hip in ten patients in the age range between 8 and 19 years have been reviewed. Results: Bone reaction (sclerosis or lysis), periosteal reaction (lamellar with single or multiple layers, or radial), tumor extent in the bone and level of soft tissues invasion have presented low specificity. Soft tissue calcifications, when considered as a whole, were non-specific. However, when those calcifications with varied shapes and sizes, nearby the affected bone (pattern I) were separated from those, thin and amorphous, away from the bone (pattern II), we have observed that the pattern I was totally non-specific, and the pattern II was found in the three cases of osteosarcoma (100%) and in only one case of Ewing's sarcoma (16.6%). Conclusion: In the present study, pattern II calcifications have shown a 100% sensitivity and 90% specificity for osteosarcoma. However, their importance may be not limited to the radiological diagnosis. Pattern II calcifications indicate probably ideal sites for biopsy. (author)

  17. Tumor de células granulares de piel mamaria : Estudio morfológico de dos casos mostrando inmunorreactividad frente a-inhibina

    OpenAIRE

    Vera Sempere, Francisco José; García, Ana; Froufe, Agustín; Corell, Emilia; Ruiz, Francisco; Mayordomo, Fernando

    2003-01-01

    Introducción: El tumor de células granulares (TCG) es una lesión infrecuente en la mama, representando solo el 6-8% de los TCG, comprometiendo a menudo a la piel mamaria. Pacientes y métodos: Se revisa la casuística de TCG mamarios del Hospital Universitario La Fe de Valencia en un período de 19 años, con un total de 8000 especímenes biópsicos mamarios con 2200 diagnósticos de cáncer, realizando de forma retrospectiva un estudio morfológico (óptico, inmunohistoquímico y ultraestructural) a pa...

  18. Tumores neuroectodérmicos primitivos periféricos de localización en el área orocervical: presentación de dos casos clínicos Peripheral primitive neuroectodermal tumors located in orocervical area: presentation of two clinical cases

    Directory of Open Access Journals (Sweden)

    C. Sánchez Acedo

    2010-03-01

    Full Text Available Introducción: Los tumores neuroectodérmicos primitivos (PNET, de primitive neuroectodermal tumors son una familia de neoplasias malignas de células pequeñas y redondas, que derivan de la cresta neural. Se distinguen tres tipos: PNET del sistema nervioso central, PNET del sistema nervioso autónomo y PNET periféricos. Los más frecuentes dentro del grupo de PNET periféricos son el neuroepitelioma periférico y el sarcoma de Ewing, que se consideran la misma neoplasia pero con diferente grado de diferenciación. Casos clínicos: Presentamos dos casos de PNET periféricos, uno de aparición en la región cervical y otro originado en el cóndilo mandibular. Discusión: Los PNET son neoplasias muy raras y altamente agresivas. En todos ellos aparecen células redondas pequeñas poco diferenciadas y una traslocación cromosómica característica del gen EWS. En general se considera que tienen un pronóstico desfavorable. Además, la baja frecuencia de estos tumores, así como la escasez de casos publicados hacen difícil valorar el tratamiento más adecuado.Introduction: Peripheral primitive neuroectodermal tumors (PNET are a family of smallround cell tumors of presumed neuroectodermal origin. This broad family can be subdivided into three major groups: PNET from the central nervous system, PNET from the autonomic nervous system or peripheral PNET. Ewing´s sarcoma and peripheral neuroepitelioma, the two most frequently encountered members of the peripheral PNET family, are considered to represent a spectrum according to the extent of neuroectodermal differentiation, ranging from the least differentiated (Ewing´s sarcoma to the most differentiated (peripheral neuroepithelioma. Case report: We present a patient with a peripheral neuroectodermal tumor located in the neck and another one with a peripheral neuroectodermal tumor of the mandibular condyle. Discussion: Peripheral neuroectodermal tumors are a very rare and aggressive tumors. They

  19. Estudo citofotométrico da expressão dos marcadores tumorais Caspase-3 e Ki-67 no adenocarcinoma gástrico Cytophotometric study of the expression of tumoral markers Caspase-3 and Ki-67 in gastric adenocarcinoma

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    Pedro Manuel Gonzales Cuellar

    2007-06-01

    Full Text Available RACIONAL: A carcinogênese gástrica é processo complexo e depende de fatores genéticos, ambientais e infecciosos. Nos últimos anos, houve grandes avanços nos campos da genética e da biologia molecular, sobre o desenvolvimento dos tumores. Os marcadores tumorais são substâncias ausentes nos tecidos normais e que podem ser identificadas em tecidos com câncer. Através de procedimentos imunoistoquímicos eles podem ser estudados. OBJETIVOS: Descrever a expressão citofotométrica do marcador tumoral Ki-67 analisando a densidade óptica e o índice de marcagem no adenocarcinoma de estômago. Descrever a expressão citofotométrica do marcador tumoral Caspase-3 analisando a densidade óptica e o índice de marcagem no adenocarcinoma de estômago. Comparar o índice de marcagem e densidade óptica dos marcadores tumorais Ki-67 e Caspase-3 no adenocarcinoma de estômago. MÉTODO: Foram selecionados, inicialmente, 58 blocos com espécime de adenocarcinoma gástrico coletados nos Serviços de Anátomo-Patologia do Hospital do Gama - Brasília (DF e Hospital Dom Orione - Araguaina (TO, e analizados no Laboratório de Citologia e Histopalogia Ltda - CITOLAB, Curitiba (PR. Foram aproveitados 31 blocos para o estudo histológico e imunoistoquímico realizado pelo sistema de análise computarizado SAMBA 4000. RESULTADOS: Das 31 lâminas estudas, 15 (48% foram marcadas pelo marcador Ki-67, 22 (71% foram marcadas pelo marcador Caspase-3 e 14 (45% marcaram com os dois marcadores. CONCLUSÕES: A expressão citofométrica do marcador Ki-67 foi observada em 15 lâminas da amostra estudada e apresentaram média do índice de marcagem de 36,85%, enquanto a densidade óptica apresentou média de 29,33 pixels. A expressão citofotométrica do marcador Caspase-3 foi observada em 22 lâminas da amostra estudada e apresentaram média do índice de marcagem de 87,71% e 60,74 pixels de média para a densidade óptica. Na comparação do índice de marcagem dos

  20. Prevalência e achados epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários de cães da Região Central do Rio Grande do Sul (1965-2012

    Directory of Open Access Journals (Sweden)

    Mariana M. Flores

    2013-04-01

    Full Text Available A prevalência e os aspectos epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários (THMP em cães foram estudados. De 7.373 cães necropsiados em 48 anos (1965-2012, 64 morreram de THMP, o que corresponde a 0,9% do total de cães que morreram por qualquer causa, 7,8% do total de cães que morreram por tumores em geral e 33,5% do total de cães que morreram por tumores hepáticos. Desses 64 casos de THMP, 51 foram revistos histologicamente, avaliados imuno-histoquimicamente e reclassificados como carcinomas (colangiocarcinomas [n=36], carcinomas hepatocelulares [n=9] e hepatocolangiocarcinoma [n=1] e sarcomas (hemangiossarcomas [n=5]. Dos cães com colangiocarcinomas e carcinomas hepatocelulares em que a idade estava disponível nos protocolos, 64,7% e 77,8% eram idosos, respectivamente. Na necropsia, colangiocarcinomas caracterizaram-se principalmente por ocorrerem em um padrão multinodular (83,3%, enquanto carcinomas hepatocelulares ocorreram tanto de forma massiva (44,4% quanto nodular (44,4%. Metástases extra-hepáticas foram vistas em 77,8% e 33,3% dos casos de colangiocarcinomas e carcinomas hepatocelulares, respectivamente, e em relação aos colangiocarcinomas afetaram principalmente pulmões (52,8%, linfonodos (50% e peritônio (19,4%. Ascite (22,2% e icterícia (22,2% foram achados associados ocasionalmente com ambos os tumores. Na histologia, a maior parte dos colangiocarcinomas (86,1% e dos carcinomas hepatocelulares (55,6% tinha padrão tubular e trabecular, respectivamente. Na imuno-histoquímica, a maioria (63,9% dos colangiocarcinomas demonstrou imunomarcação para CK7 e nenhum imunomarcou para Hep Par 1. A maioria (55,6% dos carcinomas hepatocelulares demonstrou imunomarcação para Hep Par 1 e nenhum imunomarcou para CK7. Os resultados aqui apresentados demonstram uma altíssima prevalência de THMP, principalmente colangiocarcinomas, e servem para auxiliar, através dos

  1. Pituitary Tumors

    Science.gov (United States)

    ... Tumors Oligoastrocytoma Oligodendroglioma Pineal Tumor Pituitary Tumor PNET Schwannoma Risk Factors Brain Tumor Facts Brain Tumor Dictionary ... Tumors Oligoastrocytoma Oligodendroglioma Pineal Tumor Pituitary Tumor PNET Schwannoma Risk Factors Brain Tumor Facts Brain Tumor Dictionary ...

  2. Effect of L-Arginine and L-NAME treatments on polymorphonuclear leukocytes and mononuclear cells influx during tumor growth Efeito dos tratamentos com L-Arginina e L-NAME sobre o influxo de leucócitos polimorfonucleares e células mononucleares durante o desenvolvimento tumoral

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    Olívia Teixeira Gomes Reis

    2009-04-01

    Full Text Available PURPOSE: Evaluate polymorphonuclear leukocytes (PMN's and mononuclear cells (MN's involvement in the Ehrlich´s solid tumor (ET growth. METHODS: 90 Swiss mice were inoculated with 10(7 tumor cells (sc, distributed in three groups and treated once a day, via intraperitoneal (ip, with 0.1ml of diluent, L-Arginine (20mg/Kg or L-NAME (20mg/Kg. After 7, 15 and 30 days of treatment, ten animals of each group were euthanized, the tumor mass was removed, processed and fixed for HE. Later, a morphometric analysis of the total area, parenchyma, necrosis, tumor stroma and PMN's leukocytes and MN's cells influx was performed. RESULTS: The L-Arginine treatment increased PMN's influx in the initial stage, whereas L-NAME reduced it. Our data suggests that NO effect on PMN's migration is dose-dependent. On the other hand, the MN´s cells influx was reduced by L-NAME treatment at all evaluated periods and at the same periods an increase in tumor growth was observed. CONCLUSION: At initial stages of tumor implantation, both PMN's leukocytes and MN's cells act together to control ET development.OBJETIVO: Avaliar o envolvimento de leucócitos polimorfonucleares (PMN's e células mononucleares (MN's no crescimento do Tumor Sólido de Ehrlich (TE. MÉTODOS: 90 camundongos Suíços foram inoculados com 10(7 células tumorais (sc, distribuídos em três grupos e tratados uma vez ao dia, via intraperitoneal (ip, com 0.1ml de diluente, L-Arginina (20mg/Kg ou L-NAME (20mg/Kg. Após 7, 15 e 30 dias, dez animais de cada grupo foram eutanasiados, a massa tumoral foi removida, processada e corada pela HE. Posteriormente, foi realizada análise morfométrica das áreas total, parênquima, necrose, estroma e influxo de leucócitos PMN's e células MN's. RESULTADOS: O tratamento com L-Arginina favoreceu o influxo de PMN's em períodos iniciais, enquanto o tratamento com L-NAME o reduziu. Nosso estudo sugere que o efeito do ON sobre a migração de PMN's é dose-dependente. Por

  3. Influência dos níveis de prolactina e tamanho tumoral na função hipofisária pós-operatória em macroadenomas hipofisários clinicamente não-funcionantes Influence of hyperprolactinemia and tumoral size in the postoperative pituitary function in clinically nonfuncioning pituitary macroadenomas

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    Ana Luiza Vidal Fonseca

    2002-09-01

    Full Text Available OBJETIVO: Estudar a influência da hiperprolactinemia e de tamanho tumoral na função hipofisária em macroadenomas hipofisários clinicamente não funcionantes. MÉTODOS: Foram analisados 23 pacientes com macroadenomas hipofisários clinicamente não funcionantes, com exames de imagem (tomografia computadorizada ou ressonância magnética e dosagens hormonais basais; 16 tinham provas de função hipotálamo-hipofisária (megateste pré-operatórios. Todos os tumores tiveram diagnóstico histológico e em 17 foi realizado também estudo imuno-histoquímico para os hormônios adeno-hipofisários. A análise estatística foi feita por meio dos testes t de Student, qui-quadrado, exato de Fisher e de Mc Neman. O nível de significância adotado foi 5% (pOBJECTIVE: To study the influence of hyperprolactinemia and tumoral size in the pituitary function in clinically nonfuncioning pituitary macroadenomas. METHODS: Twenty three patients with clinically nonfuncioning pituitary macroadenomas were evaluated by image studies (computed tomography or magnetic resonance and basal hormonal level; 16 had preoperative hypothalamus-hypophysial function tests (megatests. All tumors had histological diagnosis and in seventeen immunohistochemical study for adenohypophysial hormones was also performed. Student's t test, chi square test, exact test of Fisher and Mc Neman test were used for the statistics analysis . The level of significance adopted was 5% (p<0.05. RESULTS: Tumoral diameter varied of 1.1 to 4.7 cm (average=2.99 cm ± 1.04. In the preoperative, 5 (21.7% patients did not show laboratorial hormonal deficit, 9 (39.1% developed hyperprolactinemia, 13 (56,5% normal levels of prolactin (PRL and 1 (4.3% subnormal; 18 (78.3% patients developed hypopituitarism (4 pan-hypopituitarism. Nineteen patients (82.6% underwent transsfenoidal approach, 3 (13% craniotomy and 1 (4.4% combined access. Only 6 patients had total tumoral resection. Of the 17 immunohistochemical

  4. Evaluation of collective protection equipment in a hemodynamic room; Avaliacao dos equipamentos de protecao coletiva em uma sala de hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Casagrande, Saman; Silva, Ana Maria Marques da, E-mail: saman.casagrande@acad.pucrs.br, E-mail: ana.marques@pucrs.br [Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil); Real, Jessica Villa; Luz, Renata Matos da, E-mail: jessica.real@acad.pucrs.br, E-mail: renata.luz@pucrs.br [Hospital Sao Lucas (HSL/PUCRS), Porto Alegre, RS (Brazil)

    2014-07-01

    Interventional radiology has high occupational dose rates. The use of personal protective equipment (PPE) and collective protection (ECP) help to reduce the dose delivered to the individuals occupationally exposed (IOE). In order to minimize the exposure of IOE's in interventionists procedures, evaluated the attenuation of the secondary radiation produced by collective protection equipment (CPE), was used a chest non-anthropomorphic phantom of polymethylmethacrylates (PMMA), with column simulator in aluminum, with variable thicknesses and kerma rate measures the air by varying the frequency tables 15 and 30 frames / s and different exposure modes. Data were acquired initially at the height of 1.25 m, using the following combinations of the ECP: (I) unshielded, (II) with plumbum display, (III) combining skirt + display. Measured at a height of 0.5 m were acquired with and without skirt. The attenuation ranged from 83.8% to 95.4% for a thickness of 25 cm. The maximum attenuation occurred with the combination of display and skirt. There was a 5 time increase in air kerma rate to be used cine display mode, when compared to the low mode. By analyzing the frequency of the frames were obtained differences up to 3 times higher for 30 frames / s, when compared with 15 frames / s. The results show the importance of using ECP in hemodynamics services, which together with the PPE, ensure adequate protection for IOEs.

  5. Competencies evaluation of the petroleum industry local suppliers; Avaliacao de competencias dos fornecedores locais da industria do petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Marzani, Bianca Santos; Furtado, Andre Tosi [Universidade Estadual de Campinas, SP (Brazil). Inst. de Geociencias. Dept. de Politica Cientifica e Tecnologica]. E-mail: bianca@ige.unicamp.br; furtado@ige.unicamp.br

    2003-07-01

    This article presents a research proposition that focuses on competencies evaluation of the local suppliers of goods and services in the petroleum industry. Because of the new context created by the opening of the petroleum market the suppliers to face a new competition environment, exposed to the foreign suppliers that operate in a higher production scale and have great financial and technological capacities. This justifies the development of the current study because the final diagnosis will help the studied companies in their decision process by the divulgation of their weaknesses and potentialities, which will motivate an improvement in the sector. In this paper, we include technological, organizational and relational competencies. Moreover, some of the main contributions of the literature about these topics are presented, including Lall, Kim, Figueiredo, Furtado, Munier, etc. (author)

  6. Acai seeds potential assessment to generate power; Avaliacao do potencial dos carocos de acai para a geracao de energia

    Energy Technology Data Exchange (ETDEWEB)

    Padilha, Jesse Luis; Canto, Sergio Aruana Elarrat; Rendeiro, Goncalo [Universidade Federal do Para (UFPA), Belem, PA (Brazil). Lab. de Engenharia Mecanica (LABEM)], e-mail: jessepadilha@hotmail.com, e-mail: aruana@ufpa.br, e-mail: rendeiro@ufpa.br

    2006-07-01

    Para State is the major producer of Acai in Brazil. After Acai juice is removed, its seed with spherical shape has no application identified so far and is disposal in large amount at residues areas. Studies done for the EBMA showed that its high heating value is 4576 kcal/kg, has 19% of fixed carbon, 79% of volatiles matter and 1% of ash, all in dry mass basis. These figures qualify Acai seeds as a good biomass fuel to be used either at combustion or gasification process. This work show the results of a survey performed in Belem where the location of Acai residues deposit are and available amount of residue of Acai at each location. Each residue location had its coordinates recorded through a GPS and the amount of seeds registered. All the information was assembled as a data base in a SIG system. This information allowed to calculation the annually amount of available energy to be used to generate power. (author)

  7. Diagnóstico e prognóstico dos tumores pulmonares neuroendócrinos mediante microscopia eletrônica e análise multivariavel de agrupamento Using electron microscopy and multivariate cluster analysis to determine diagnosis and prognosis in cases of neuroendocrine lung carcinoma

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    Cecília Aparecida Vaiano Farhat

    2008-10-01

    Full Text Available OBJETIVO: Estabelecer, com ajuda do microscópio eletrônico, critérios que possibilitem uma diferenciação mais exata entre os quatro tipos maiores de tumores neuroendócrinos pulmonares: tumor carcinóide típico e atípico, carcinoma de grandes células neuroendócrino e carcinoma de pequenas células. MÉTODOS: Todos os tumores foram avaliados morfometricamente e 16 variáveis foram relacionadas com diferenciação das células tumorais; estas variáveis foram analisadas sob microscopia eletrônica com ajuda de um analisador de imagem digital em 27 tumores. A avaliação através da microscopia eletrônica revelou que todos os tumors investigados podiam ser classificados a um dos quarto tipos listados acima. A análise das variáveis morfométricas foi usada para agrupar os tumores em três grandes grupos, os quais foram relacionados à sobrevivência pelas curvas de Kaplan Meier. RESULTADOS: Os três grupos de carcinoma neuroendócrino associaram-se às curvas da sobrevivência, as quais mostraram características ultrastruturais na microscopia eletrônica de significância prognóstica distinta. Os tumores foram contidos em três grupos bem definidos, que representam o espectro da diferenciação neuroendócrina: tumor carcinóide (grupo 1; tumor carcinóide atípico e carcinoma de grandes células neuroendócrino (grupo 2; e carcinoma de pequenas células (grupo 3. O grupo 2 representa um espectro intermediário na carcinogênese neuroendócrina, entre o carcinóide típico e o carcinoma de pequenas células. CONCLUSÕES: Nossos achados confirmam que a microscopia eletrônica é uma ferramenta útil no diagnóstico e prognóstico dos casos de tumores pulmonares.OBJECTIVE: To establish reproducible electron microscopic criteria for identifying the four major types of neuroendocrine tumors of the lung: carcinoid; atypical carcinoid; large cell neuroendocrine carcinoma; and small cell carcinoma. METHODS: Measurements were made on electron

  8. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

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    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  9. Expressão imuno-histoquímica de p53 na discriminação do comportamento biológico dos tumores de glândulas salivares Immunohistochemical expression of p53 on the biological behavior of salivary gland tumors

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    Kelen Christine do Nascimento Souza

    2005-06-01

    Full Text Available INTRODUÇÃO: Mutações no gene TP53 têm sido identificadas em várias neoplasias, incluindo as de glândulas salivares (NGS. Entretanto não existe consenso sobre o significado biológico da expressão de p53 nessas lesões. OBJETIVOS: Avaliar a marcação imuno-histoquímica do antígeno p53 em NGS, investigando possíveis diferenças entre lesões benignas e malignas, entre diferentes tipos histológicos e entre tumores malignos que: 1 não desenvolveram metástases; 2 emitiram metástases; e 3 metástases de NGS. MATERIAL E MÉTODO: Foram avaliados 16 casos de adenomas pleomórficos (AP, 17 lesões malignas que não apresentaram metástase durante a proservação (sete carcinomas adenóides císticos [CAC] e dez mucoepidermóides [CM], 13 tumores malignos que emitiram metástases (nove CAC e quatro CM e, ainda, 12 metástases regionais ou distantes (cinco CAC e sete CM. Por marcação imuno-histoquímica (estreptavidina-biotina-peroxidase, índices médios de localização do antígeno p53 foram estabelecidos para cada tumor. Para análise, utilizaram-se testes de Mann-Whitney e Kruskal-Wallis, com nível de significância de 5%. RESULTADOS: Foram observadas diferenças estatisticamente significantes nos índices médios de imunomarcação de p53 entre lesões benignas e malignas (p = 0,03 e entre os diferentes tipos histológicos, notadamente entre o AP e o CM (p = 0,02. Todavia houve marcada sobreposição dos intervalos de índices de expressão entre os grupos testados. Nenhuma diferença de expressão foi observada entre as neoplasias malignas quanto ao seu comportamento metastático. CONCLUSÃO: Embora a expressão de p53 tenha sido detectada em todos os subtipos de NGS, a marcação imuno-histoquímica deste antígeno não permitiu discriminar os tumores malignos quanto ao seu comportamento biológico.BACKGROUND: Mutations in the tumor suppressor gene TP53 have been found in many tumors, including salivary gland neoplasms (SGN

  10. Prevalência e achados epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários de cães da Região Central do Rio Grande do Sul (1965-2012 Prevalence and epidemiological, pathological and immunohistochemical aspects of primary canine malignant hepatic tumors in Rio Grande do Sul, Brazil (1965-2012

    Directory of Open Access Journals (Sweden)

    Mariana M. Flores

    2013-04-01

    Full Text Available A prevalência e os aspectos epidemiológicos, anatomopatológicos e imuno-histoquímicos dos tumores hepáticos malignos primários (THMP em cães foram estudados. De 7.373 cães necropsiados em 48 anos (1965-2012, 64 morreram de THMP, o que corresponde a 0,9% do total de cães que morreram por qualquer causa, 7,8% do total de cães que morreram por tumores em geral e 33,5% do total de cães que morreram por tumores hepáticos. Desses 64 casos de THMP, 51 foram revistos histologicamente, avaliados imuno-histoquimicamente e reclassificados como carcinomas (colangiocarcinomas [n=36], carcinomas hepatocelulares [n=9] e hepatocolangiocarcinoma [n=1] e sarcomas (hemangiossarcomas [n=5]. Dos cães com colangiocarcinomas e carcinomas hepatocelulares em que a idade estava disponível nos protocolos, 64,7% e 77,8% eram idosos, respectivamente. Na necropsia, colangiocarcinomas caracterizaram-se principalmente por ocorrerem em um padrão multinodular (83,3%, enquanto carcinomas hepatocelulares ocorreram tanto de forma massiva (44,4% quanto nodular (44,4%. Metástases extra-hepáticas foram vistas em 77,8% e 33,3% dos casos de colangiocarcinomas e carcinomas hepatocelulares, respectivamente, e em relação aos colangiocarcinomas afetaram principalmente pulmões (52,8%, linfonodos (50% e peritônio (19,4%. Ascite (22,2% e icterícia (22,2% foram achados associados ocasionalmente com ambos os tumores. Na histologia, a maior parte dos colangiocarcinomas (86,1% e dos carcinomas hepatocelulares (55,6% tinha padrão tubular e trabecular, respectivamente. Na imuno-histoquímica, a maioria (63,9% dos colangiocarcinomas demonstrou imunomarcação para CK7 e nenhum imunomarcou para Hep Par 1. A maioria (55,6% dos carcinomas hepatocelulares demonstrou imunomarcação para Hep Par 1 e nenhum imunomarcou para CK7. Os resultados aqui apresentados demonstram uma altíssima prevalência de THMP, principalmente colangiocarcinomas, e servem para auxiliar, através dos

  11. Estudo citofotométrico da expressão dos marcadores tumorais Ki-67 e CD34 no adenocarcinoma de próstata Cytophotometric expression of tumor antigen markers Ki-67 and CD-34 in prostate adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Paulo Faria Barbosa

    2009-12-01

    Full Text Available OBJETIVO: Quantificar a porcentagem da imunomarcação no índice de marcagem e densidade óptica do Ki-67 e CD34 no adenocarcinoma de próstata e compará-las entre si. MÉTODOS: Foram estudados, através de imunoistoquímica, o Ki-67 e o CD34 em 34 casos de adenocarcinoma de próstata provenientes de prostatectomia radical no período de 2000 a 2005 realizado no Hospital Regional do Gama em Brasília. Estes marcadores foram quantificados através do software SAMBA 4000 ® Sistema de Análise Microscópica de Busca Automática e do software IMMUNO® para análise das variáveis índice de marcagem e densidade óptica. Para avaliação da associação entre as expressões do marcador, foi estimado o coeficiente de correlação de Spearman. Para a comparação do tipo de lesão, foi usado o teste t de Student em amostras pareadas e não paramétrico de Wilcoxon. RESULTADOS: Dos 34 blocos que foram para leitura dos marcadores tumorais, 15 marcaram expressão com Ki-67, 34 com CD34 e 14 com ambos os marcadores. O índice de marcagem do CD34 teve valor mediano de 72,72%, valor mínimo 5,14% e valor máximo 88,81%. O índice de marcagem do Ki-67 teve mediana de 73,78%, mínimo de 16,87% e máximo de 87,47%. A densidade óptica do CD34 teve mediana de 48,33, mínimo de 35,65 e máximo de 85,86. Na densidade óptica do Ki-67 o valor da mediana foi 40,03 sendo a mínima de 21,53 e a máxima de 52,43. CONCLUSÃO: A expressão citofotométrica do Ki-67 teve índice médio de marcação de 64,04% e o CD34 de 61,64%. A expressão citofotométrica da densidade óptica média do Ki-67 foi de 39,49 e no CD34 de 53,69. Há diferença significativa entre a imunomarcação do Ki-67 e CD34 em relação à densidade óptica (p=0,025, não havendo diferença significativa no índice de marcagem (p=0,470.OBJECTIVE: To quantify the percentage of immunostaining through the labeling index as well as the optical density of Ki-67 and CD34 in prostate adenocarcinoma and

  12. Ultra-estrutura dos mastócitos de diferentes tipos histológicos de mastocitoma em cães Mast cell ultrastructure in different types of canine mast cell tumor

    Directory of Open Access Journals (Sweden)

    F.A.R. Sueiro

    2002-06-01

    Full Text Available Este trabalho teve por objetivo estudar as diferenças ultraestruturais de mastócitos neoplásicos de diferentes tipos histológicos de mastocitoma em cães, usando microscopia eletrônica de transmissão Os resultados mostraram que o núcleo e os grânulos citoplasmáticos são as estruturas mais indicadas para se avaliar o grau de anaplasia celular e o estádio de indiferenciação do tumor.The objective of this work was study the ultrastructural differences among the different histologic types of mast cell tumors in dogs collected in vivo. The ultrastructural analyses showed that the nuclei and cytoplasmic granules characteristics are the best structures to be appointed on evaluating the undifferentiation stage of this tumor.

  13. Oral tumors in dogs: clinical aspects, exfoliative cytology and histopathology Neoplasias orais em cães: avaliação dos aspectos clínicos, histopatologia e citologia esfoliativa

    Directory of Open Access Journals (Sweden)

    Cláudia Ronca Felizzola

    1999-09-01

    Full Text Available In order to establish the diagnosis and prognosis of tumors of the oral cavity, a comparative study was carried out in 130 dogs considering age, sex, breed, clinical aspects, exfoliative cytology as well as histopathology. Exfoliative cytology revealed: 100% negative for benign non-odontogenic tumors, 97.91% negative benign odontogenic tumors and 77.92% positive for malignant tumors. Histopathology showed: 59.23% malignant tumors (33.08% malignant melanoma, 9.23% squamous cell carcinoma, 5.38% osteosarcoma, 2.31% fibrosarcoma, 2.31% angiosarcoma, 1.54% malignant mesenchymal tumors, 1.54% malignant fibrohistiocytoma, 1.54% lymphoma, 0.77% leyomyosarcoma, 0.77%% epithelioid sarcoma and 0.77% angiofibrosarcoma; 36.92% benign odontogenic tumors (25.38% peripheral odontogenic fibroma, 10.0% ossifyng fibroma and 1.54% odontoma in addition to 3.85% benign non-odontogenic tumors (1.54% fibroma, 0.77% plasmocytoma, 0.77% pilomatrixoma and 0.77% giant tumor cells. These results permit us to conclude that exfoliative cytology was an efficient, safe, quick and noninvasive method and could be used for early evaluation of oral cancer.Objetivou-se o estudo comparativo em tumores de cavidade bucal de animais de espécie canina de acordo com sexo, faixa etária, raça, aspectos clínicos, citologia esfoliativa e histopatologia, para estabelecer diagnóstico dessas neoplasias, tendo sido utilizados 130 cães, encaminhados ao Hospital Veterinário (HOVET da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Os resultados obtidos na citologia esfoliativa foram: 100% de negativos para neoplasias benignas não odontogênicas; 97,91% de negativos para neoplasias benignas odontôgenicas e 77,92% de positivos para neoplasias malignas. Obtiveram-se os seguintes resultados no exame histopatológico: neoplasias malignas - 59,23% (melanoma 33,08%, carcinoma epidermóide 9,23%, osteossarcoma 5,38%, fibrossarcoma 2,31%, angiossarcoma 2

  14. Utilidad de la familia miR-200 como marcador pronóstico en dos tumores de origen endodérmico: Cáncer de Pulmón y Cáncer Colorrectal

    OpenAIRE

    Tejero Villalba, Rut

    2014-01-01

    Durante los últimos años se ha visto que los microRNAs (miRNAs) han emergido como prometedores marcadores moleculares en múltiples tipos de cáncer, incluyendo el cáncer de pulmón de célula no pequeña (CPCNP) y el cáncer colorrectal (CRC), dos modelos tumorales de mismo origen endodérmico, que hemos estudiado en este trabajo. Los miRNAs son moléculas de RNA de 19 a 25 nucleótidos no codificantes, que inhiben la traducción a proteína. La familia miR-200 está formada por cinco miembros clasifica...

  15. Fatores prognósticos e preditivos dos tumores caninos definidos com auxílio da imuno-histoquímica Prognostic and predictive factors of canine tumours defined with immunohistochemistry's assistance

    Directory of Open Access Journals (Sweden)

    Rodrigo dos Santos Horta

    2012-06-01

    Full Text Available A imuno-histoquímica pode ser aplicada na oncologia veterinária para a definição do imunofenótipo neoplásico, com possibilidades ilimitadas de utilização. A técnica baseia-se na identificação de antígenos "in situ", que podem apresentar valor prognóstico e terapêutico. A expressão de receptores de estrógeno e progesterona está diretamente relacionada ao melhor prognóstico para os neoplasmas mamários, enquanto a super-expressão do receptor KIT (CD117, proteínas Ki-67 (MIB-1, VEGF, CD31 e COX-2 podem ser associados à progressão tumoral para vários tipos histológicos. Essa associação possui valor preditivo em potencial, tendo em vista a possibilidade da utilização de bloqueadores específicos. Esta revisão tem como objetivo apresentar as possibilidades da utilização da imuno-histoquímica nos tumores de cães, visando à definição mais precisa do prognóstico e a indicação de tratamentos específicos para cada paciente.Immunohistochemistry can be applied in veterinary oncology to define the immunophenotype of neoplastic cells with unlimited possibilities of application. The technique is based on the identification of antigens "in situ", which may have prognostic and therapeutic value. Expression of estrogen and progesterone is directly related to better prognosis for breast cancer, while over-expression of receptor KIT (CD117 proteins Ki-67 (MIB-1, COX-2, VEGF and CD31 can be associated with tumor progression for several histological types. This association has a potential predictive value, due to the possibility of using specific blockers. This revision aims at presenting the possibilities of immunohistochemical's application in tumors of dogs, searching for a more precise definition of the prognosis and indication of specific treatments for each patient.

  16. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  17. Tumores malignos de pálpebra Malignant eyelid tumors

    OpenAIRE

    Luis Henrique Schneider Soares; Cecília Vasconcellos Bello; Andrea Kaercher Loureiro Bing Reis; Ricardo Rodrigues Nunes; Eduardo Marques Mason

    2001-01-01

    Objetivos: Estudar a incidência de tumores malignos de pálpebra no Hospital Banco de Olhos de Porto Alegre. Métodos: Estudo retrospectivo dos casos de tumores malignos de pálpebra no período de 1985 a 1997, que tiveram diagnóstico confirmado por exame anátomopatológico. Resultados: Foram encontradas 54 neoplasias malignas, sendo 75,92% carcinoma basocelular, 12,96% carcinoma espinocelular, 7,40% melanoma e 1,85% lentigo maligna. A maioria dos pacientes apresentava mais de 40 anos e não houve ...

  18. From DOS to UNIX

    International Nuclear Information System (INIS)

    Union Pacific Resources (UPRC) is a large independent operator with about 100 petroleum engineers. UPRC has a reasonably sophisticated PC network with many hundreds of PC's connected via several local area network (LAN) servers. Essentially all engineers have a 386 based PC on their desk with access to a host of software packages, peripheral devices and to mainframe computers. Many engineers are now acquiring 486 based PC's. UPRC's solution has involved migrating from a DOS-based platform on individual user's desk to UNIX workstations. Dozens of UNIX workstations are networked; some are on the desk, while others are located in central locations. Reservoir simulation, geostatistical modeling, image processing and log analysis are now done exclusively on the UNIX workstations. Numerous DOS-based programs, however, have not yet been migrated into the UNIX environment. This paper describes the topography of both PC DOS and UNIX workstation networks in UPRC, and examine the flow of information in each network configuration to identify differences. The successes and failures of various techniques for providing access to both platforms will be presented

  19. Classificação dos tumores da mama: atualização baseada na nova classificação da Organização Mundial da Saúde de 2012 Classification of tumours of the breast: an update based on the new 2012 World Health Organization Classification

    Directory of Open Access Journals (Sweden)

    Helenice Gobbi

    2012-12-01

    Full Text Available A Organização Mundial da Saúde lançou em julho de 2012 a 4ª edição da Classificação dos Tumores de Mama. Nesta revisão, será realizada uma breve abordagem das principais mudanças da nova classificação, com ênfase nas implicações diagnósticas e terapêuticas. As principais mudanças foram: (i o fascículo atual é dedicado integralmente aos tumores da mama; (ii os tumores epiteliais foram agrupados de forma diferente, com o reconhecimento de nove tipos especiais e suas variantes e 11 tipos raros de tumores mamários, além do carcinoma ductal invasivo sem outra especificação. Foram reconhecidos e incluídos novos códigos para as variantes de carcinoma lobular, carcinomas com características medulares e subtipos de carcinomas metaplásicos; (iii foram sugeridos novos escores para avaliação imuno-histoquímica de receptores hormonais (> 1% de células positivas e receptor do fator de crescimento epidérmico 2 (HER2 (> 30% células fortemente positivas, circundando toda membrana; (iv apresentou-se nova abordagem da classificação molecular e genômica do câncer de mama, incluindo novos testes que empregam perfil de expressão gênica para predição da evolução clínica e resposta terapêutica; (v foi mantida a terminologia tradicional das lesões proliferativas intraductais, não se adotando a terminologia neoplasia intraepitelial ductal; (vi reconheceu-se a importância prognóstica de se distinguir hiperplasia lobular atípica e carcinoma lobular in situ (CLIS dentro do espectro das neoplasias lobulares; (vii as lesões de células colunares (alteração e hiperplasia de células colunares sem atipias foram separadas das atipias epiteliais planas, cuja evolução biológica ainda é pouco definida. Espera-se amplo uso da nova classificação, por patologistas e oncologistas, beneficiando pacientes, alvos principais dos avanços diagnósticos e terapêuticos.The World Health Organization released the 4th edition of

  20. AVALIAÇÃO BIOQUÍMICA DO ÁCIDO SIÁLICO COMO BIOMARCADOR TUMORAL EM NOVILHAS CRIADAS EM PROPRIEDADE ENDÊMICA PARA HEMATÚRIA ENZOÓTICA DOS BOVINOS

    Directory of Open Access Journals (Sweden)

    MARCOS COELHO DE CARVALHO

    2011-06-01

    Full Text Available Pteridium aquilinum (bracken fern is one of the most concerning toxic vegetables in many countries in the world. Therefore, science aims to find ways for the epidemiological control of bovine intoxication with the purpose of making early diagnoses of Bovine Enzootic Hematuriae. Researches have shown a high correlation between the excessive production of mucoprotein by animals with Bovine Enzootic Hematuriae and sialic acid, proving that this acid acts as an inflammatorybiochemical marker associated to bladder tumor development. Based on this information, serum sialic acid levels of clinically healthy Nellore heifers (control group were statistically compared to Nellore heifers raised in bracken fern endemic properties (experimental group. The average level of serum sialic acid of the control groups was not different from the sialic acid level of the affected group (0.611 ± 0.225 g/L and 0.615 ± 0.258 g/L, respectively. Results obtained in the present study demonstrate no differences of the sialic acid average levels between the groups. Therefore, measurement ofsialic acid serum levels was not effective as a neoplasic biochemical marker in Nellore heifers continuously fed with bracken fern.

  1. Dos cupas complutenses

    Directory of Open Access Journals (Sweden)

    Stylow, Armin U.

    2006-12-01

    Full Text Available Publication of two cupae from the ancient territory of Complutum. One was found in excavations in Alcalá de Henares (Madrid and is unpublished; of the other one, which came to light in the church of Alovera (Guadalajara, a new reading is given.Se publican dos cupas del antiguo territorio de Complutum, una, inédita, encontrada en excavación en Alcalá de Henares (Madrid, y la segunda, procedente de la iglesia de Alovera (Guadalajara, con una nueva lectura.

  2. Tumor estromal gastrointestinal: estudo de oito casos

    OpenAIRE

    Amico Enio Campos; Coimbra Cesar Wilson Bastos; Bugalho Luiz Antônio; Nai Gisele Alborghetti; Matos Ricardo Marcondes; Machado Cibele Chuery; Silva Fabrício Colacino

    2006-01-01

    OBJETIVO: O diagnóstico e tratamento dos tumores estromais gastrointestinais (TEGI) têm evoluído a partir de estudos recentes de genética e biologia molecular. Tais avanços têm refletido em melhor sobrevivência dos doentes. MÉTODOS: Foi realizado estudo retrospectivo no período de novembro/1998 a julho/2004, em instituição universitária e em clínica privada dos autores, que identificou portadores de TEGI a partir de positividade para c-kit (CD 117), ao exame imunoistoquímico. RESULTADOS: Dos ...

  3. Evaluation of influence of fertilizers in radium concentration from tomato culture; Avaliacao da influencia dos fertilizantes nos teores de radio encontrados na cultura do tomate

    Energy Technology Data Exchange (ETDEWEB)

    Lauria, Dejanira C. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil). Dept. de Protecao Radiologica Ambiental; Ribeiro, Fernando C.A.; Alleluia, Irene B. [Instituto Nacional de Tecnologia (INT), Rio de Janeiro, RJ (Brazil). Div. de Meio Ambiente; Perez, Daniel V. [Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA), Rio de Janeiro, RJ (Brazil). Lab. de Analises de Solos e Plantas

    2001-07-01

    The fertilizer contribution to radio uptake by tomato plants was assessed. Tomato and soil samples from four different plantations were analyzed: two using organic fertilizer and two using phosphate fertilizer. The Ra concentrations in eight of the most used tomato fertilizers were determined. The concentration values ranged from 14 to 221 Bq/kg of Ra-226 and from 25 to 176 Bq/kg of Ra-228. Owing to the low Ra concentration and to the used fertilizer quantities, the fertilizers would not increase significantly the Ra soil concentration. However, the highest soil to plant concentration ratios were found in the plantations using phosphate fertilizers. This outcome pointed out the higher Ra availability in the phosphate fertilizer plantations than in the organic fertilizer plantations, showing a possible positive influence of phosphate fertilizers for the tomato Ra uptake. Due to the phosphate fertilizer used, the dose could increase from 0,05 Sv/year to 0,24 Sv/year. However this increase is not significant face the ingestion average worldwide effective dose. (author)

  4. An evaluation of the potential impacts of the 'gas aid'; Uma avaliacao dos impactos potenciais do 'auxilio gas'

    Energy Technology Data Exchange (ETDEWEB)

    Biazotto, Ana Lidia; Anuatti Neto, Francisco [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Economia, Administracao e Contabilidade

    2004-07-01

    In May of 2001, the prices to the final consumer of GLP were set free in the whole country; this procedure had the intention, to continue process of deregulation in the fuel sector, in accord with the Oil Law. The release of the prices of sale and shipping subsidies elimination, along with the elimination of the crossed subsidy, required the adoption of a 'gas aid' social program, aimed to guarantee the low profit families necessities attendance that would pay the additional fuel costs. The objective of this paper is to evaluate the gas aid program as its covering level and the economic and distributive efficiency. The study encloses the metropolitans regions investigated in the IBGE Family Budget Research of 1996. With base in the previously identification of the potential beneficiary of the program, and with them consumption profile, it was possible to evaluate the potential impact of the withdrawal of the subsidy in the hypothesis of the family be or not beneficiary of the program. Assuming that the targeting is perfect, it is compared the transference politics to the low profit families in relation to the previous politics of subsidize crossed. (author)

  5. Evaluation by instrumented indentation of the damage caused by gamma radiation on polymeric materials; Avaliacao por indentacao instrumentada dos danos causados pela radiacao gama em materiais polimericos

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, M.P.; Azevedo, E.C.; Miquelin, C.A.; Soboll, D.S., E-mail: helunica@yahoo.com.b [Universidade Tecnologica Federal do Parana (DAFIS/UTFPR), Curitiba, PR (Brazil). Dept. Academico de Fisica

    2010-07-01

    Several materials with densities close to water are used as phantoms in dosimetry. Such materials are damaged because they are exposed to radiation, the surface layers suffer the largest changes. This damage can be assessed by instrumented indentation. This paper investigates the variations in hardness and elastic modulus of samples of polymethyl-methacrylate, polyvinyl chloride, polyacetal and polypropylene before and after being irradiated with gamma radiation dose 500 Gy, using a Nanoindeter XP, with applied loads between 1 mN and 400 mN. The results are discussed correlating the variations in the mechanical properties of polymers with their applications. (author)

  6. Effects of blue light irradiation on dental enamel remineralization in vitro; Avaliacao dos efeitos promovidos pela radiacao azul na remineralizacao do esmalte dentario in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Ilka Tiemy

    2009-07-01

    This study aimed to investigate the effects of blue radiation on dental enamel remineralization. In addition, a methodology of analysis was developed to evaluate alterations of enamel mineral content by optical coherence tomography. Artificial lesions were formed in bovine dental enamel slabs by immersing the samples in under saturated acetate buffer (2 mL/mm{sup 2} e 6.25 mL/mm{sup 2}). The lesions were irradiated with blue LED (l=455{+-}20nm), with radiant power of 110 mW, irradiance of 1.4 W/cm{sup 2}, radiant exposure of 13.8 J/{sup c}m2 and exposure time of 10 s. Remineralization was induced by pH-cycling model during 8 days. Cross-sectional hardness and optical coherence tomography (OCT) were used to assess mineral changes after remineralization. Hardness data showed that non-irradiated enamel lesions presented higher mineral content than irradiated ones and this difference was more evident in lesions formed in higher solution volume. The analysis of OCT signal also demonstrated that the mineral content of non-irradiated group was higher than in irradiated one; however, no significant difference was observed. Furthermore, significant differences in OCT sign were detected between sound and demineralized enamel. Based on the results obtained in the present study it can be concluded that blue radiation caused an inhibition of enamel remineralization. The methodology adopted for OCT analysis allowed the quantification of enamel mineral loss; however, the remineralization process could not be evaluated by this technique. (author)

  7. Evaluation of socio-economic impacts on the electric power market - Brazil; Avaliacao dos impactos socio-economicos sobre o mercado de energia eletrica - Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Caio, Leonardo Santos; Savastano, Paulo Curi; Borges, Gastao A. Fontoura [Eletricidade de Sao Paulo S.A., SP (Brazil)

    1993-12-31

    Based on a basic model of financial and economic planning, giving special emphasis to the determining variables, this work proceeded an analysis of the historical aspects of the electric power market facing the economic growth and social and politic events. Also discussed are some aspects concerning environmental protection 7 refs., 1 fig.

  8. Quality of life evaluation of workers for diagnostic radiology services; Avaliacao da qualidade de vida dos trabalhadores de servicos de radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Ivani Martins

    2011-07-01

    The main objective of this study was to evaluate the quality of life (QOL) of diagnostic radiology services workers at a hospital of Sao Paulo city. It aimed also to draw the profile of these workers identifying the variables, as its influence on their quality of life. A descriptive exploratory study with qualitative and quantitative approaches was carried out. The data were collected using the questionnaires: the abbreviated instrument for the assessment of the QOL, World Health Organization Quality of Life Instrument bref (WHOQOL-bref) and a questionnaire including the social demographic variables, work conditions and the variables that express the lifestyle of individuals, both questionnaires self-applied. The sample was formed by 118 workers, among them: physicians, technologists/technicians in radiology, nurses, technicians and assistants in nursing, and others health professionals. The data analysis included descriptive statistics, nonparametric tests and the use of a linear regression model. The reliability of the instrument for the studied sample was verified by Cronbach's Alpha Coefficient ({alpha}). The WHOQOL-bref proved to be an adequate instrument, with a good level of internal consistency ({alpha}=0.884), being easily and quickly administrated for the evaluation of the QOL. The study provided an overview of the perception of quality of life of the studied group. (author)

  9. Evaluation of occupational dose from the special procedures guided by fluoroscopy: cardiac catheterism; Avaliacao da dose ocupacional oriunda dos procedimentos especiais guiados por fluoroscopia: cateterismo cardiaco

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Amanda Juliene da

    2011-07-01

    The purpose of this study was to evaluate the dose received by health professionals in the hemodynamic sector of a university hospital in Sao Paulo city. A self-applied questionnaire was used to delineate the profile of health professionals, taking into account sociodemographic variables and variables related to the work with ionizing radiation. The assessment of occupational doses was performed by consulting of the individual dose records of the institution database from 2000 to 2009. A total of 240 records was evaluated, corresponding to 38 active professionals (2009), divided in different professional category: physician, nurses, radiologic technologists and nursing assistants. The annual doses were compared with the limits established by national regulatory authorities. Based on the effective doses received and recorded during the studied period, experimental measures were performed with TL dosimeters in five physicians to evaluate the equivalent dose, in the left hand, during hemodynamic procedures. In addition, the radioprotection measures adopted by health professionals were verified. This study allowed delineating the profile of medical staff that integrates the hemodynamic service as well as knowing the distribution of their doses in relation to limits over the years. (author)

  10. Occupational exposure prevention program to oil and gas industry; Antecipacao, reconhecimento, avaliacao e controle dos riscos ambientais em uma planta de petroleo e gas

    Energy Technology Data Exchange (ETDEWEB)

    Moraes, Paulo Sergio de [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Palierini, Renato Martins [TWA Brasil, Sao Caetano do Sul, SP (Brazil)

    2005-07-01

    PETROBRAS/TRANSPETRO Pipelines and Terminals have 500 regular employees and 5.064 out sourced workers in its Southeast Division. The out sourced employees work under 125 contracts involving a wide range of activities such as maintenance, pipeline operation, pipeline launching, engineering, administrative and auxiliary services. Among these workers, 1.200 peoples are subjected to occupational exposure, which may be present in the industrial process or in the products transported in our pipelines, e.g. industrial noise, sulfidric gas, toluene, xylene and benzene (recognized as a carcinogen according to ACGIH and Brazilian Ministry of Labour). Our PPRA (acronym in Portuguese for Occupational Exposure Prevention Program) involves the workforce and fosters health by anticipation, recognition, evaluation and control of the situations that may result in injuries. Further actions include the procurement of equipment for detection of these agents not only in the air but also diluted in liquids and the introduction of state-of the- art technologies for a better process control. The priority is the acquisition of equipment for collective protection not forgetting the individual protection equipment (IPE) and the required training. Implementation of this program counted on the effective involvement of the managers, contract supervisors and HSE professionals whose main task was to advise all involved parts on the use the Risk Analysis Methods tailored for Occupational Hygiene. Furthermore, these information will be used in a info system called SD-2000 that will gather and compare Health, Hygiene e Human Resources data in order to support the professional in the management and decision making process. (author)

  11. Situational quality evaluation of mammography services at state of Minas Gerais, Brazil; Avaliacao situacional da qualidade dos servicos de mamografia do estado de Minas Gerais, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Joana, Georgia S.; Oliveira, Mauricio de; Andrade, Mauricio C. de; Cesar, Adriana C.Z., E-mail: georgia.santos@saude.mg.gov.b, E-mail: mauricio.cavalcanti@saude.mg.gov.b, E-mail: adrianac@saude.mg.gov.b, E-mail: mauricio.oliveira@saude.mg.gov.b [Secretaria de Estado da Saude de Minas Gerais (SVS/SES-MG), Belo Horizonte, MG (Brazil). Superintendencia de Vigilancia Sanitaria; Oliveira, Marcio A.; Nogueira, Maria do S., E-mail: marcio.alves@saude.mg.gov.b, E-mail: mnogue@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Peixoto, Joao E. [Instituto Nacional de Cancer (INCA), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    Breast cancer is the leading cause of cancer deaths in women. Currently, the most effective method for early detection of this cancer is the mammography, and to achieve the standard definition and contrast, the whole system of imaging must operate under optimal conditions. This paper presents the results of the assessment of mammography centers in the state of Minas Gerais, which was held with the aim of supporting the actions of the State Program of Quality Control in Mammography. These results indicated that less than half of mammography achieved the minimum standard of image quality, endorsing the need of a monitoring more efficient and effective, which led to the establishment, in Minas Gerais, of the monthly monitoring of image quality in mammography. (author)

  12. Evaluation of occupational exposure in interventionist procedures using Monte Carlo Method; Avaliacao das exposicoes dos envolvidos em procedimentos intervencionistas usando metodo Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Santos, William S.; Neves, Lucio P.; Perini, Ana P.; Caldas, Linda V.E., E-mail: williathan@yahoo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Belinato, Walmir; Maia, Ana F. [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Departamento de Fisica

    2014-07-01

    This study presents a computational model of exposure for a patient, cardiologist and nurse in a typical scenario of cardiac interventional procedures. In this case a set of conversion coefficient (CC) for effective dose (E) in terms of kerma-area product (KAP) for all individuals involved using seven different energy spectra and eight beam projections. The CC was also calculated for the entrance skin dose (ESD) normalized to the PKA for the patient. All individuals were represented by anthropomorphic phantoms incorporated in a radiation transport code based on Monte Carlo simulation. (author)

  13. Evaluation of advanced oxidative processes in contaminated soil of the Pernambuco state; Avaliacao dos processos oxidativos avancados num solo contaminado do estado de Pernambuco

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Paula T.S. e [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Quimica; Santos, Suenia S. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Engenharia Quimica; Barros Neto, Benicio de [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Quimica Fundamental; Dorea, Haroldo S. [Universidade Federal de Sergipe (UFS), Aracaju, SE (Brazil); Motta Sobrinho, Mauricio A. da; Silva, Valdinete L. da [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

    2004-07-01

    In this work were used the following techniques of advanced oxidative processes: hydrogen peroxide, Fenton reagent and heterogeneous photocatalysis (TiO2). These processes have shown as an alternative technology to the treatment of some environmental matrices. The soil studied was contaminated by an oil mixture proceeding from an emptying in the patio of an industry of the state of Pernambuco. This soil has about 14,5 g/Kg of total organic carbon and 3400 mg/kg of TPH. Two planning factorial 23 were composed: one in relation to hydrogen peroxide and the other to titanium dioxide, in order to find the best conditions for the contaminant degradation. The variables and the studied levels for the former was: FeSO4 - 0,18 M (without, 4 and 8 ml); Adjustment of pH (3, without, without); Time of exposition to the sun (8h, 12h, 16h). The volumes of used peroxide in the assays were 80 and 40 ml. In relation to the second planning, were studied the following conditions: TiO2 (g) (without,5;0,75;1,0), volume H2O (0, 2,5 and 5 ml) and time of exposition to the sun (8, 40, 72h). In relation to the first planning a destruction of 84% of the oil was achieved. However, in relation to 2nd the planning non-significant degradation was obtained, and to study other conditions ought to be investigated. (author)

  14. Evaluation of the backtime of the water heating systems at the residential sector; Avaliacao do tempo de retorno dos sistemas de aquecimento solar de agua no setor residencial

    Energy Technology Data Exchange (ETDEWEB)

    Raimo, Patricia Abdala; Faga, Murilo Tadeu Werneck [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-graduacao em Energia]. E-mail: patriciaar@iee.usp.br; murfaga@iee.usp.br

    2006-07-01

    This work presents an evaluation of the investment return for the residential consumer when exclusive using the water heating system. The investment backtime will be evaluated as function of the collector efficiency converting solar radiation to heat and the consumption avoided of final energy, electricity or natural gas. The comparison result is shown for three irradiation levels and for any water volume whatsoever to be heated.

  15. Evaluation of the normal thoracic and abdominal aorta diameters by computerized tomography; Avaliacao dos diametros normais da aorta toracica e abdominal pela tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Lucarelli, Claudio Luiz

    1995-07-01

    The study was undertaken to evaluate, through computerized tomography, the diameters of the normal thoracic and abdominal aorta, as well as they are connected to gender, age and body surface area; and the ratio between measurements obtained at the ascending and descending limbs of the thoracic aorta, and between the abdominal aortic diameters. For that reason, we measured the widest anteroposterior diameters of the thoracic aortas at the levels of the arch, the root, the pulmonary artery, and the thoracic-abdominal transition, as well as the level of the emergence of the superior mesenteric artery, of the renal hila and just cephalad to the bifurcation of the abdominal aortas of 350 patients without cardiovascular diseases who had undergone computerized tomography of the thorax and/or abdomen for any other reasons. Observation and statistic analyses led us to conclude that: 1) both the thoracic and abdominal aortic diameters are reduced from their proximal to their distal portions; 2) the body surface influences the size of the aorta, although only extreme variations alter the vessel's caliber; 3) vessel diameter was observed to gradually increase with age; 4) men were found to have larger diameters than age matched women; 5) the ratio between the ascending and descending aortic diameters varies according to gender and age; 6) the relations between abdominal aortic diameters measured at the level of renal hila and cephalad to the bifurcation are independent from gender and age. But the relation between those measured at the level of the superior mesenteric artery and cephalad to the bifurcation are linked to gender, but not to age. (author)

  16. Evaluation of the impacts of the gas aid program in Sao Paulo state, Brazil; Avaliacao dos impactos do programa do auxilio-gas no estado de Sao Paulo

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Thiago Pamplona [Universidade de Sao Paulo (FEARP-USP), Ribeirao Preto, SP (Brazil). Fac. de Economia, Administracao e Contabilidade; Anuatti Neto, Francisco [Universidade de Sao Paulo (PIPGE/USP), SP (Brazil). Programa Interunidades de Pos-Graduacao em Energia

    2008-07-01

    The objective of this article is to evaluate the coverage and the economic impact of the Federal Government Program Aid Gas (Auxilio Gas) , started in the year of 2002. The evaluation covers only the state of Sao Paulo, using as source the Research of Familiar Budgets of IBGE 2002/2003. To evaluate the coverage of 'Aid-Gas' the targeted population is compared with the population that effectively received the benefit. To evaluate the economic impact of the program a test of significance of dummy variable that differentiate weight gas consumption on income for those attended by the program, controlled by Working-Leser function that models the covariates of gas expenses. A low coverage of the program was evidenced, only 32,098 families had received the benefit (4,01%) out of 786.929 families targeted group, those with per capita income was inferior the half minimum wage. The economic impact had mixed results. In one hand program beneficiaries would spend a larger percentage of income with gas consumption than those not reached; on the other hand, they would have access larger quantities of the product. If the food consumption and the gas consumption are correlated, and the families not benefited by the program are rationed, it is possible to confirm that the introduction of the program would increase welfare of families. (author)

  17. Impact of an evaluation quality program of mammography service of Distrito Federal - Brasil; Impacto de um programa de avaliacao da qualidade dos servicos de mamografia do Distrito Federal

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Rosangela da Silveira

    2002-07-01

    Cancer is the second cause of death for Brazilian women and breast cancer is the most common neoplasm amongst women. Mammography is an essential tool for diagnosis and early detection of this disease. In order to be effective, the mammography must be of good quality. This study sought to evaluate the quality of these services in the Federal District and the impact of an intervention involving inspection and education. The universe of 41 mammography services in the Federal District was studied between June and August 2001. Two instruments were used 1) a proposed evaluation protocol of the National Agency for Health Surveillance (ANVISA) and 2) a protocol for evaluation of image quality and care. The intervention included the initial inspection, a training activity, and a formal notification by the health authorities of the Federal District. Image quality was compared before and after the intervention. The existing infrastructure in the DF is of good quality, but the services have low productivity, they do not treat patients sent by the public health system, they have an inadequate geographic distribution with most in the central neighborhood, and the low income female population has restricted access to early detection of cancer. Of the 36 services who completed the study, none was above 90% conformity in image quality before the interventions, whereas 10 were above 90% afterwards. The greatest improvements were in chassis maintenance (services without chassis with defects went from 10 to 25), breast compression (services in conformity went from 7 to 20) and visualization of micro calcifications (32 services in conformity before and 35 afterwards). The results of the ANVISA protocol bore no relation to final image quality, a central issue for early cancer detection. In spite of the existence of many services, most were not of quality and population access was restricted. The intervention under study was shown to be effective for improving quality, nevertheless ongoing action is needed to resolve the remaining problems and to increase the impact. The proposed method for public monitoring should be modified to evaluate primarily the quality of the final exam provided to the consumer. (author)

  18. Importance of evaluation of uncertainties on the measurement of natural gas and petroleum volumes; Importancia da avaliacao das incertezas na medicao dos volumes de petroleo e gas natural

    Energy Technology Data Exchange (ETDEWEB)

    Silva Filho, Jose Alberto Pinheiro da; Oliveira, Thiago Barra Vidal de; Mata, Josaphat Dias da [PETROBRAS, Rio de Janeiro, RJ (Brazil)], Emails: jose.pinheiro@petrobras.com.br, thiagovidal@petrobras.com.br, josaphat@petrobras.com.br; Val, Luiz Gustavo do [Instituto de Qualidade e Metrologia (IQM), Rio de Janeiro, RJ (Brazil)], E-mail: gdoval.iqm@petrobras.com.br

    2009-07-01

    The measurement is considered as the 'cash register' of the enterprises, increasing the accuracy and the exigence at each step when come close to the delivery points, where the 0.1 % of differences are discussed. The work presents the approach used in the evaluation of measurement uncertainties in the volumes obtained of petroleum and natural gas at the processes of production in Brazil, and in the international level as well.

  19. Tumor vaccines

    International Nuclear Information System (INIS)

    Tumor vaccines have several potential advantages over standard anticancer regiments. They represent highly specific anticancer therapy. Inducing tumor-specific memory T-lymphocytes, they have potential for long-lived antitumor effects. However, clinical trials, in which cancer patients were vaccinated with tumor vaccines, have been so far mainly disappointing. There are many reasons for the inefficiency of tumor vaccines. Most cancer antigens are normal self-molecules to which immune tolerance exists. That is why the population of tumor-specific lymphocytes is represented by a small number of low-affinity T-lymphocytes that induce weak antitumor immune response. Simultaneously, tumors evolve many mechanisms to actively evade immune system, what makes them poorly immunogenic or even tolerogenic. Novel immunotherapeutic strategies are directed toward breaking immune tolerance to tumor antigens, enhancing immunogenicity of tumor vaccines and overcoming mechanisms of tumor escape. There are several approaches, unfortunately, all of them still far away from an ideal tumor vaccine that would reject a tumor. Difficulties in the activation of antitumor immune response by tumor vaccines have led to the development of alternative immunotherapeutic strategies that directly focus on effector mechanisms of immune system (adoptive tumor- specific T-lymphocyte transfer and tumor specific monoclonal antibodies). (author)

  20. Nuclear dacryoscintigraphy: lacrimal drainage evaluation in oncologic patients after face tumors surgery; Dacriocintilografia nuclear: avaliacao da drenagem lacrimal em pacientes oncologicos pos-cirurgicos de tumores de face

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Elisabeth F.; Guimaraes, Celsa M. Maliska; Antonucci, Jane B.; Terence, P.M.D.; Penque, Emerson [Instituto Nacional do Cancer, Rio de Janeiro, RJ (Brazil)

    2002-07-01

    The dacryoscintigraphy is a non invasive method of the functional integrity of the drainage lacrimal system. A person with normal lacrimal drainage the radioactivity instilled through in the palpebral fissure is immediately drained for the lacrimal sac at 5 to 10 seconds. Above the next 30 to 50 seconds there is a drainage of the canaliculi, nasolacrimal sac and from the nasal inferior meatus. The canaliculus, the lacrimal sac and the nasolacrimal duct are well defined on delayed images. The abnormalities consist of the obvious obstruction and lack of drainage in any of this structures or prolonged time of the drainage through of the nasolacrimal duct. Before any surgery in this region this relation have to be identified. The nasal lacrimal duct can be damaged by a excessive resection of the anterior layer of the natural ostium. If the inferior shell is resected near the bottom, the duct can be damaged resulting in an occlusion of the nasolacrimal duct and epiphora. The nasolacrimal duct can be locked in case of inflammatory disease, trauma or neoplasic process. (author)

  1. Palavras dos editores

    Directory of Open Access Journals (Sweden)

    Nelkis de la Orden Medina

    2005-12-01

    Full Text Available Este número da revista RESI está sendo editado em conjunto por mim e pelo novo editor Jorge Muniz Barreto. A revista tem agora nova sede, o Departamento de Informática e de Estatística da Universidade Federal de Santa Catarina. No que a me diz respeito, tenho a satisfação após estes 4 anos de trabalho de ter contribuído no lançamento e consolidação da revista, a qual considero uma ferramenta útil no âmbito universitário. Agradeço a todos os que fizeram possível a realização deste projeto: aos membros do conselho editorial, ao corpo de avaliadores e principalmente aos autores de trabalhos publicados. Gostaria de agradecer ao novo editor sua excelente disposição para aceitar este desafio e lhe desejo uma gestão editorial de muito sucesso. Tenho a certeza que estamos iniciando uma nova etapa da revista que permitirá um crescimento maior da mesma, na qual continuaremos a colaborar de forma permanente. Campo Largo, dezembro de 2005. Nelkis de la Orden Medina, Editora-Chefe. Repletos de idealismo iniciamos com a edição 6 da Revista Eletrônica de Sistemas de Informação nossa atuação como Editor-Chefe. Esperamos honrar os sucessos obtidos pela revista nos cinco números anteriores, e tornar RESI, cada vez mais útil a seus leitores. Para isto temos planos e contamos além do Conselho Editorial e Revisores, ouvir também a opinião dos leitores de modo informal. Para isto criamos um MSN-Space onde os leitores poderão colocar suas sugestões (operacional e conhecer alguns membros tanto do conselho como revisores. Para vê-lo acessem:http://spaces.msn.com/members/resireveletron Os trabalhos apresentados dão continuidade ao estilo das edições anteriores. São seis artigos, abordando assuntos relacionados à Sistemas de Informação. Estes artigos enriquecem o acervo de trabalhos publicados na revista RESI e mostram o panorama das pesquisas que estão sendo desenvolvidas no Brasil e países amigos. Dentre os planos para o ano

  2. Mammary tumors

    International Nuclear Information System (INIS)

    Mammary neoplasia is one of the more common malignancies affecting domestic species. Despite their importance, they are often over- diagnosed, undertreated and subject to several misconceptions propagated by veterinarians and pet owners alike. Mammary neoplasia is the most frequent tumor type encountered in the female accounting for almost half of all malignancies reported. The canine has the highest incidence of mammary tumors of all domestic species. In the dog, about 65 percent of mammary tumors are benign mixed tumors, and 25 percent are carcinomas. The rest are adenomas, myoepitheliomas, and malignant mixed tumors. The age distribution of mammary tumors closely follows the age distribution of most tumors in the dog. Mammary tumors are rare in dogs 2 years old, but incidence begins to increase sharply at approximately 6 years of age. Median age at diagnosis is about 10 years. No breed predilection has been consistently reported

  3. Brain Tumors

    Science.gov (United States)

    A brain tumor is a growth of abnormal cells in the tissues of the brain. Brain tumors can be benign, with no cancer cells, or ... cancer cells that grow quickly. Some are primary brain tumors, which start in the brain. Others are metastatic, ...

  4. Odontogenic Tumors

    OpenAIRE

    TAHSİNOĞLU, Melih

    2013-01-01

    DefinitionThe neoplasms that consist of the cells considered specialized for odontogenesis, and their product (dentin, enamel, cementum) are called odontogenic tumors.ClassificationTo initiate odontogenesis, epithelium is a must. Same rule holds for the odontogenic tumors: without odontogenic epithelium, odontogenic tumors cannot be, without the induction of odontogenic epithelium odontogenic mesenchyme cannot develop.

  5. Brain Tumors

    Science.gov (United States)

    A brain tumor is a growth of abnormal cells in the tissues of the brain. Brain tumors can be benign, with no cancer cells, ... cancer cells that grow quickly. Some are primary brain tumors, which start in the brain. Others are ...

  6. Tumor Markers

    Science.gov (United States)

    ... guidelines on a variety of topics, including tumor markers for breast cancer, colorectal cancer, lung cancer, and others. The ... of recurrence 70-Gene signature (Mammaprint®) Cancer type: Breast ... Can tumor markers be used in cancer screening? Because tumor markers ...

  7. Urogenital tumors

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1994-03-01

    An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

  8. Wilms Tumor

    Science.gov (United States)

    ... Kids Up for Sports Pregnant? Your Baby's Growth Cerebral Palsy: Caring for Your Child All About Food Allergies Wilms Tumor KidsHealth > For Parents > Wilms Tumor Print A A A Text Size What's in this article? Signs and Symptoms Diagnosis Treatment Caring for Your Child en español Tumor ...

  9. Inibidores dos microtúbulos

    OpenAIRE

    Monteiro, AC

    2014-01-01

    Trabalho apresentado no Serviço de Oncologia do Hospital Prof. Doutor Fernando Fonseca, numa sessão de Farmaco-Oncologia, a 14/05/2014. As sessões eram destinadas à abordagem das diversas classes de citostáticos e outros fármacos usados no tratamento do cancro. Esta apresentação contempla a classe dos inibidores dos microtúbulos ou agentes anti- tubulina, abordando a natureza química bem como a farmacodinâmica e a farmacocinética dos compostos.

  10. Differences in absorbed doses at risk organs and target tumoral of planning(PTV) in lung treatments using two algorithms of different calculations; Diferencias en las dosis absorbidas en organos de riesgo y volumen tumoral de planificacion (PTV) en tratamientos de pulmon usando dos algoritmos de calculo diferentes: pencil beam y collpased cone

    Energy Technology Data Exchange (ETDEWEB)

    Uruena Llinares, A.; Santos Rubio, A.; Luis Simon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.

    2006-07-01

    The objective of this paper is to compare, in thirty treatments for lung cancer,the absorbed doses at risk organs and target volumes obtained between the two used algorithms of calculation of our treatment planning system Oncentra Masterplan, that is, Pencil Beams vs Collapsed Cone. For it we use a set of measured indicators (D1 and D99 of tumor volume, V20 of lung, homogeneity index defined as (D5-D95)/D prescribed, and others). Analysing the dta, making a descriptor analysis of the results, and applying the non parametric test of the ranks with sign of Wilcoxon we find that the use of Pencil Beam algorithm underestimates the dose in the zone of the PTV including regions of low density as well as the values of maximum dose in spine cord. So, we conclude that in those treatments in which the spine dose is near the maximum permissible limit or those in which the PTV it includes a zone with pulmonary tissue must be used the Collapse Cone algorithm systematically and in any case an analysis must become to choose between time and precision in the calculation for both algorithms. (Authors)

  11. Evaluation of radiotherapy and chemotherapy treatment in patients of oral squamous cell carcinoma; Avaliacao dos resultados dos tratamentos radioterapico e quimioterapico em pacientes portadores de carcinoma espinocelular na cavidade bucal

    Energy Technology Data Exchange (ETDEWEB)

    Sannomiya, Eduardo Kazuo [Universidade de Santo Amaro (UNISA), SP (Brazil). Faculdade de Odontologia. Dept. de Diagnostico e Cirurgia; Medici Filho, Edmundo; Moraes, Luiz Cesar de; Castilho, Julio Cezar de Melo [UNESP, Sao Jose dos Campos, SP (Brazil). Faculdade de Odontologia. Dept. de Cirurgia, Periodontia e Radiologia; Furukawa, Souhei [Osaka Univ. (Japan). Faculdade de Odontologia. Dept. de Radiologia e Radioterapia Buco-Maxilo-Facial

    2003-12-01

    We evaluated the effectiveness of radiotherapy combined with chemotherapy in patients with oral squamous cell carcinoma. Therefore, 1042 cases where reviewed in School Dentistry - Osaka Univ. Seven hundred and fifteen were male and three hundred and twenty-seven were female. Ora cancer was affected more male than female patients, with mean age of 582 years old. The tongue was the most common anatomic localization of oral cancer. In tongue, the use of external radiotherapy y combined with brachytherapy and brachytherapy isolated presented better results than chemotherapy combined with external radiotherapy. In buccal mucosa, there was not differences in the treatment's results using external radiotherapy and combined chemotherapy and external radiotherapy. In tongue's floor and upper and jaw gingiva the combined treatment with chemotherapy and external radiotherapy presented better results than isolated external radiotherapy. (author)

  12. Tumor de Krukenberg Krunkenberg's tumor

    Directory of Open Access Journals (Sweden)

    Daisy Hernández Durán

    2011-09-01

    Full Text Available El tumor de Krukenberg supone el 30-40 % de los cánceres metastásicos al ovario y el 1-2 % de todos los tumores malignos de ovario. En la actualidad, y pese a que el concepto de tumor de Krukenberg ha sido usado para referirse a todos los tumores metastásicos del ovario, se consideran como tal a los que tienen un origen digestivo. Su pronóstico es malo con raras supervivencias más allá del año. Se presenta un caso de una paciente femenina de 38 años de edad, que ingresa por ascitis moderada, anorexia y pérdida de peso, a la cual se le realizó una laparotomía con el posible diagnóstico de un proceso oncoproliferativo del ovario y el diagnóstico histopatológico arrojó un tumor de Krukenberg.Krukenberg's tumor accounts for 30-40 % of ovarian metastatic cancer and for the 1-2 % of all ovarian malignant tumors. Nowadays and in spite of the fact that the concept of Krukenberg' tumor has been used to refer to all ovarian metastatic tumors those with a digestive origin, its prognosis if bad with only a few survivals beyond one year. This is the case of a female patient aged 38 admitted due to a moderate ascites, anorexia and lose weight undergoes laparotomy with the possible diagnosis of a oncoproliferous ovarian process and the histopathological diagnosis showed a Krukenberg's tumor.

  13. Brain tumor

    International Nuclear Information System (INIS)

    BNCT in the past was not widely accepted because of poor usability of a nuclear reactor as a neutron source. Recently, technical advancements in the accelerator field have made accelerator-based BNCT feasible. Consequently, clinical trials of intractable brain tumors have started using it since 2012. In this review, our clinical results obtained from conventional reactor-based BNCT for treatment of brain tumors are introduced. It is strong hope that accelerator-based BNCT becomes a standard therapy for current intractable brain tumors. (author)

  14. Bone Tumor

    Science.gov (United States)

    ... the knee in either the femur (thigh) or tibia (shinbone). Other common locations include the hip and ... bone that is weakened by a tumor to fracture, or break. This may be severely painful. Occasionally, ...

  15. Dos problemas de sintaxis adverbial

    Directory of Open Access Journals (Sweden)

    Claudia Chuaqui Farrú

    2006-06-01

    Full Text Available El presente trabajo trata de dos problemas de sintaxis adverbial, a saber, de los adverbios como adyacentes de sustantivos y de la función sintáctica de los adverbios "más" y "menos" en adiciones y sustracciones matemáticas. (This article tackles two problems of adverbial function, i.e., adverbs as noun modifiers and the syntactic function of the adverbs "más" and "menos" in mathematicaladditions and substractions.

  16. Sobre a psicopatologia dos atos

    Directory of Open Access Journals (Sweden)

    Roberto Calazans

    2015-07-01

    Full Text Available Este artigo pretende apresentar a psicopatologia dos atos a partir do esquema de Jacques Lacan sobre a angústia. Diferenciamos os acting-out, a passagem ao ato, os sintomas, as inibições e a angústia fazendo uma duplicação do esquema de Lacan levando em consideração os registros do simbólico, do real e do imaginário. Esse esquema permite uma abordagem da questão dos atos do sujeito sem cair em uma perplexidade do clínico, nem na confusão entre os atos e a ação. Permite também uma melhor orientação do clínico em relação às diversas modalidades de respostas subjetivas que não se restringem à questão sintomática, que é o campo inaugural da clínica psicanalítica desde a sua fundação por Sigmund Freud. Acreditamos contribuir, assim, para um maior esclarecimento desse esquema no ensino de Lacan e para que ele possa servir de orientação para o tratamento dos atos do sujeito na clínica.

  17. Avaliacao da seguranca de diferentes doses de suplementos de acido folico em mulheres do Brasil

    Directory of Open Access Journals (Sweden)

    Quenia dos Santos

    2013-10-01

    Full Text Available OBJETIVO Avaliar a distribuição da ingestão de ácido fólico e a segurança de diferentes doses de suplementos em mulheres em idade reprodutiva. MÉTODOS Foram utilizados dados de consumo a partir de dois dias não consecutivos de registro alimentar de 6.837 mulheres em idade reprodutiva (19 a 40 anos participantes do Inquérito Nacional de Alimentação, módulo da Pesquisa de Orçamentos Familiares 2008-2009. Médias e percentis de consumo habitual de folato natural e ácido fólico foram estimados utilizando o método do National Cancer Institute . Cinco cenários foram simulados somando-se diferentes doses diárias de fortificação (400 mcg, 500 mcg, 600 mcg, 700 mcg e 800 mcg ao ácido fólico oriundo dos alimentos consumidos pelas mulheres. Comparou-se o total de ácido fólico (dieta + suplemento com o nível máximo de ingestão tolerável (UL = 1.000 mcg para definir a dose segura de suplementação. RESULTADOS Mulheres com ingestão habitual de ácido fólico acima do nível máximo de ingestão tolerável foram observadas para doses de suplemento de 800 mcg (7,0% das mulheres. Abaixo desse valor, qualquer dose de suplementação mostrou-se segura. CONCLUSÕES O uso de suplementos de até 700 mcg de ácido fólico mostrou-se seguro.

  18. Imaging of brain tumors

    International Nuclear Information System (INIS)

    The contents are diagnostic approaches, general features of tumors -hydrocephalus, edema, attenuation and/or intensity value, hemorrhage, fat, contrast enhancement, intra-axial supratentorial tumors - tumors of glial origin, oligodendrogliomas, ependymomas, subependymomas, subependymal giant cell astrocytomas, choroid plexus papilloma; midline tumors - colloid cysts, craniopharyngiomas; pineal region tumors and miscellaneous tumors i.e. primary intracerebral lymphoma, primitive neuroectodermal tumors, hemangioblastomas; extraaxial tumors - meningiomas; nerve sheath tumors -schwannomas, epidermoids, dermoids, lipomas, arachnoid cysts; metastatic tumors (8 refs.)

  19. Lung tumors

    International Nuclear Information System (INIS)

    This volume 17 in the series of clinicoradiological seminars deals with malignant lung tumors. Twenty-four authors contributed to this comprehensive survey of current knowledge and methods, with about half of the contributions in the monography being concerned with aetiology and epidemiology of the lung, anatomy of the lung and anatomy of lung tumors, as well as with the current diagnostic methods. The latter are discussed in great detail and include CT, differential diagnosis of pulmonary nodules, angiography for lung tumor diagnostics, and nuclear medical diagnostics. The main issue of the other contributions is a new approach in oncology that works towards interdisciplinary exchange of information among experts in search for improved therapies. (orig./MG) With 44 tabs., 111 figs

  20. Brain tumors

    International Nuclear Information System (INIS)

    Magnetic Resonance Tomography (MRT) is the method of choice for the diagnostics of cerebral gliomas, but the differentiation of tumour tissue from unspecific tissue changes is limited. Positron emission tomography (PET) and Single-Photon-Emission-Computed Tomography (SPECT) may offer relevant additional information which allows for a more accurate diagnostics in unclear situations. Especially, radiolabeled amino acids offer a better delineation of cerebral gliomas which allows an improved guidance of biopsy, planning of surgery and radiation therapy. Furthermore, amino acid imaging appears to be useful to differentiate tumor recurrence from unspecific posttherapeutic tissue, to predict the prognosis especially in low grade gliomas and to monitor the metabolic response during tumor therapy. (orig.)

  1. Avaliacao da Relacao entre a Doenca Hepatica Nao Gordurosa e CAD utilizando TCMF

    Directory of Open Access Journals (Sweden)

    Duran Efe

    2014-01-01

    Full Text Available Fundamento: Alguns fatores de risco para a aterosclerose são acompanhados pela doença hepática gordurosa não alcoólica (DHGNA. Desejamos usar a tomografia computadorizada multi-fatias (TCMF como a técnica para encontrar relação entre a DHGNA e a doença arterial coronariana (DAC. Objetivo: A relação entre a DHGNA e a DAC foi investigada através de TCMF. Métodos: Um total de 372 indivíduos com ou sem sintomas cardíacos, que foram submetidos à angiografia por TCMF, foram incluídos no estudo. Os pacientes foram divididos em dois grupos, de acordo com a presença da DHGNA. Os segmentos arteriais coronarianos foram avaliados visualmente via angiografia por TCMF. Com base no grau de estenose arterial coronariana, aqueles com placas ausentes ou mínimas foram considerados como normais, enquanto aqueles que apresentavam estenose de menos do que 50% e no mínimo uma placa foram considerados como portadores da doença arterial coronariana não obstrutiva (não-obsDAC. Os pacientes que apresentaram no mínimo uma placa e estenose arterial coronariana de 50% ou mais foram considerados como portadores de doença arterial coronariana obstrutiva (obsDAC. A DHGNA foi determinada de acordo com o protocolo de TCMF, utilizando a densidade hepática. Resultados: De acordo com a densidade hepática, o número de pacientes com doença hepática gordurosa não alcoólica (grupo 1 foi de 204 (149 homens, 54,8% e com fígado normal (grupos 2 foi de 168 (95 homens, 45.2%. Houve 50 (24,5% não-obsDAC e 57 (27,9% casos de obsDAC no Grupo 1, e 39 (23,2% não-obsDAC e 23 (13,7% casos de obsDAC no Grupo 2. Conclusões: O presente estudo utilizando TCMF demonstrou que a frequência da doença arterial coronariana em pacientes com NAFDL foi significativamente superior do que nos pacientes em NAFDL.

  2. Tumores do plexo coróideo Choroid plexus tumors

    OpenAIRE

    GERALDO PIANETTI; LUIZ FERNANDO FONSECA

    1998-01-01

    É feita análise estatística, semiológica, terapêutica e da evolução de 15 crianças portadoras de tumor do plexo coróideo, tratadas cirurgicamente no Serviço de Neuropediatria dos Hospitais das Clínicas (UFMG) e São Francisco de Assis, num período de 15 anos (1981 a 1996). A idade variou de quatro meses a 16 anos, com média de três anos e seis meses, dez tinham menos de dois anos; nove eram do sexo feminino; 14 tinham sinais de hipertensão intracraniana; em todas elas a presença do tumor foi c...

  3. Remessas de recursos dos imigrantes

    Directory of Open Access Journals (Sweden)

    Ana Cristina Braga Martes

    2006-08-01

    Full Text Available AS REMESSAS contribuem para o desenvolvimento local e para redução da pobreza? Essa é a pergunta-chave que os estudos recentes sobre migrações internacionais têm levantado. O que se está procurando compreender é de que modo as remessas poderiam afetar positiva ou negativamente a economia dos países de origem dos imigrantes. Discutir o papel e o significado das remessas implica, assim, uma discussão em torno da existência (ou não de um "campo de positividades" do fenômeno migratório internacional. O principal objetivo deste artigo é contribuir para essa discussão por meio de um estudo empírico do caso brasileiro que adota as remessas como foco. Para tanto, é identificado o perfil das remessas e dos remetentes, assim como os objetivos e os beneficiários do dinheiro enviado. A pesquisa usa uma abordagem baseada em entrevistas em profundidade e survey não-representativo (Boston e Governador Valadares.DO REMITTANCES contribute to local development and the reduction of poverty? What are the consequences of the dollars sent by the migrants to the people, families, and organizations that receive them in the cities of origin? These are the key questions that recent studies have raised. According to some authors "migration is inevitable and has the potential to be quite positive in terms of development and reduction of poverty. The policies that have their origins in this principle will be more successful than those that attempt to oppose, intransigently, both globalization and the migration of people in space". Do current international migrations produce positive local development effects? The main objective of this article is to contribute to this discussion through an empirical study of the Brazilian case, which takes remittances as its focus. Thus, we identify who the immigrants are who send remittances from the United States to Brazil, to what ends the remittances are directed, who the beneficiaries are, and how the remittances

  4. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  5. Brain tumor - children

    Science.gov (United States)

    ... children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children) ... The cause of primary brain tumors is unknown. Primary brain tumors may ... (spread to nearby areas) Cancerous (malignant) Brain tumors ...

  6. Brain tumor (image)

    Science.gov (United States)

    Brain tumors are classified depending on the exact site of the tumor, the type of tissue involved, benign ... tendencies of the tumor, and other factors. Primary brain tumors can arise from the brain cells, the meninges ( ...

  7. Brain Tumor Diagnosis

    Science.gov (United States)

    ... Tumors Tumor Grading and Staging Types of Tumors Risk Factors Brain Tumor Statistics Webinars Anytime Learning About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Careers Brain ...

  8. perspectiva dos Enfermeiros de Psiquiatria

    OpenAIRE

    Silva, Marcelo Filipe Alves da

    2013-01-01

    Tem-se verificado, nas últimas décadas, um aumento da tentativa de suicido ao nível da população mundial, com números preocupantes no que concerne à prática ou tentativa de colocar um fim à própria vida. A enfermagem na área da Psiquiatria, num contexto multidisciplinar, quer ao nível clínico, quer hospitalar, surge como uma via importante de prevenção, identificação e encaminhamento dos pacientes que, por diversos motivos, possam proceder ao suicídio, ou pelo menos à sua tentativa. Per...

  9. Pediatric brain tumors

    International Nuclear Information System (INIS)

    Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics. (orig.)

  10. Pediatric brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Poussaint, Tina Y. [Department of Radiology, Boston, MA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Huisman, Thierry A.G.M. [Charlotte R. Bloomberg Children' s Center, Johns Hopkins Hospital, Division of Pediatric Radiology and Pediatric Neuroradiology, Baltimore, MD (United States)

    2015-09-15

    Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics. (orig.)

  11. American Brain Tumor Association

    Science.gov (United States)

    ... For Health Care Professionals About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Careers Brain Tumor Information Brain Anatomy Brain Tumor Symptoms Diagnosis Types of Tumors Tumor Grade Risk Factors Brain Tumor Statistics ABTA Publications Brain Tumor ...

  12. Brain Tumor Surgery

    Science.gov (United States)

    ... Pediatric Caregiver Resource Center About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Careers Brain Tumor Information Brain Anatomy Brain Tumor Symptoms Diagnosis Types of Tumors Tumor Grade Risk Factors Brain Tumor Statistics ABTA Publications Brain Tumor ...

  13. Teratoid Wilms′ tumor - A rare renal tumor

    Directory of Open Access Journals (Sweden)

    Biswanath Mukhopadhyay

    2011-01-01

    Full Text Available Teratoid Wilms′ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms′ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy was done and the patient had an uneventful recovery. Histopathology report showed teratoid Wilms′ tumor.

  14. Tumor thrombus

    DEFF Research Database (Denmark)

    Ravina, Mudalsha; Hess, Søren; Chauhan, Mahesh Singh; Jacob, Mattakorottu Joseph; Alavi, Abass

    2014-01-01

    PURPOSE: Thrombosis in cancer may manifest itself as venous thromboembolic disease or tumor thrombosis (TT). We present our experience with incidentally detected TT on FDG PET/CT in 21 oncologic patients. PATIENTS AND METHODS: We retrospectively reviewed all FDG PET/CT examinations during a 5-year......-one patients were included; the most common malignancies were renal cell carcinoma (n=6), hepatocellular carcinoma (n=3), and lung cancer (n=3). Indication for the scan was initial staging (n=15) and suspected recurrence (n=6). Several vessels were affected, the most common was the inferior vena cava (n=14...

  15. Perfil dos idosos que cochilam

    Directory of Open Access Journals (Sweden)

    Ariene Angelini dos Santos

    2013-12-01

    Full Text Available Esse estudo objetivou caracterizar os idosos que cochilam segundo as características sociodemográficas e de fragilidade. Estudo descritivo, transversal, recorte do projeto multicêntrico Fragilidade em Idosos Brasileiros. Foram avaliados 1.866 idosos utilizando-se questionário sociodemográfico. A fragilidade foi avaliada usando o fenótipo proposto por Fried. Os dados foram tratados com estatística descritiva. Os resultados apontaram que o perfil do idoso que cochila foi constituído predominantemente por mulheres, casadas, aposentadas, pré-frágeis, com média de idade de 73 anos, quatro anos de estudo, renda familiar mensal de 3,9 salários mínimos, com 4,4 filhos e que residiam apenas com eles. Os idosos relataram cochilar em média 5,9 dias por semana, com duração de 53,5 minutos por cochilo. Conhecer o perfil do idoso que cochila contribui para os profissionais de saúde desenvolverem ações em relação aos problemas de sono dos idosos frágeis/pré-frágeis, prevenindo, minimizando ou resolvendo esses problemas.

  16. Neurobiologia dos transtornos do controle dos impulsos The neurobiology of impulse control disorders

    OpenAIRE

    Williams, Wendol A.; Potenza, Marc N.

    2008-01-01

    OBJETIVO: Revisar os artigos sobre substratos neurobiológicos dos transtornos do controle dos impulsos. O jogo patológico é o foco central desta revisão na medida em que a maioria dos estudos biológicos dos formalmente classificados como transtornos do controle dos impulsos examinou este transtorno. MÉTODO: Foi feita uma busca no banco de dados Medline de artigos publicados de 1966 até o presente para identificar aqueles relevantes para serem revisados neste artigo. DESFECHOS: Estudos pré-clí...

  17. Leitura rapida do KDIGO 2012: Diretrizes para avaliacao e manuseio da doenca renal cronica na pratica clinica

    Directory of Open Access Journals (Sweden)

    Gianna Mastroianni Kirsztajn

    2014-03-01

    Full Text Available Os autores desta "leitura rápida" apresentam os dados que consideraram mais relevantes na versão 2012 do KDIGO referente à avaliação e manuseio da doença renal crônica. Não se trata da opinião dos autores, mas sim de uma apresentação mais concisa das diretrizes, que podem ser úteis na prática clínica.

  18. Adolescent and Pediatric Brain Tumors

    Science.gov (United States)

    ... abta.org Donate Now Menu Adolescent & Pediatric Brain Tumors Brain Tumors In Children Pediatric Brain Tumor Diagnosis Family ... or Complete our contact form Adolescent & Pediatric Brain Tumors Brain Tumors In Children Pediatric Brain Tumor Diagnosis Family ...

  19. Aplicação clínica dos marcadores tumorais séricos em carcinoma não-pequenas células do pulmão Clinical application of serum tumor markers in patients with non-small cell lung carcinoma

    OpenAIRE

    JEFFERSON LUIZ GROSS; RIAD NAIM YOUNES; JOSÉ ALEXANDRE MARZAGÃO BARBUTO; FABIO JOSÉ HADDAD; DANIEL DEHENZELIN

    2000-01-01

    O valor clínico dos marcadores tumorais séricos em câncer de pulmão é incerto. Objetivos: Avaliar a associação da concentração sérica de marcadores tumorais com a extensão da neoplasia e seu valor prognóstico. Casuística e método: Entre fevereiro de 1995 e setembro de 1997 foram estudados 103 pacientes, no Departamento de Cirurgia Torácica do Hospital do Câncer. Antes do tratamento os pacientes foram submetidos à coleta de sangue para dosagem da concentração do CEA, CYFRA21.1, CA15.3, CA19.9,...

  20. Os organismos geneticamente modificados e a rotulagem dos alimentos - uma análise a partir dos direitos dos consumidores

    Directory of Open Access Journals (Sweden)

    Marcello Vitor Rocha Cota

    2015-11-01

    Full Text Available Ao longo do presente trabalho serão analisados os organismos geneticamente modificados (OGMs frente aos riscos à saúde alimentar e ao meio ambiente, sobretudo o princípio da precaução e a rotulagem dos produtos. A partir de uma dimensão comparativa de três realidades distintas, isto é, a estadunidense, a europeia, com ênfase mercado ao português, e a brasileira – sob um prisma ambiental, a rotulagem dos produtos será confrontada com os direitos dos consumidores, embora em determinadas ocasiões, diante da inexistência de informações adequadas e claras dos produtos, que estão sendo ofertados e consumidos, os consumidores não sabem o que estão consumindo.

  1. Childhood Brain Tumors

    Science.gov (United States)

    ... They are among the most common types of childhood cancers. Some are benign tumors, which aren't ... can still be serious. Malignant tumors are cancerous. Childhood brain and spinal cord tumors can cause headaches ...

  2. Brain Tumors (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Brain Tumors KidsHealth > For Parents > Brain Tumors Print A ... radiation therapy or chemotherapy, or both. Types of Brain Tumors There are many different types of brain ...

  3. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... wireless devices Head injuries Smoking Hormone therapy SPECIFIC TUMOR TYPES Brain tumors are classified depending on: Location of the ...

  4. Childhood Brain Tumors

    Science.gov (United States)

    Brain tumors are abnormal growths inside the skull. They are among the most common types of childhood ... still be serious. Malignant tumors are cancerous. Childhood brain and spinal cord tumors can cause headaches and ...

  5. Neuroendocrine Tumor: Statistics

    Science.gov (United States)

    ... Tumor > Neuroendocrine Tumor - Statistics Request Permissions Neuroendocrine Tumor - Statistics Approved by the Cancer.Net Editorial Board , 04/ ... the body. It is important to remember that statistics on how many people survive this type of ...

  6. Tumors and Pregnancy

    Science.gov (United States)

    Tumors during pregnancy are rare, but they can happen. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. The most common cancers in pregnancy are breast cancer, cervical cancer, lymphoma, and melanoma. ...

  7. Tratamento atual dos miomas Current treatment of leiomyomas

    Directory of Open Access Journals (Sweden)

    Helena von Eye Corleta

    2007-06-01

    Full Text Available Leiomiomas são tumores benignos. Eles surgem no miométrio e contêm quantidade variável de tecido conjuntivo fibroso. Cerca de 75% dos casos são assintomáticos, encontrados ocasionalmente durante exame abdominal, pélvico bimanual ou ultra-sonografia. Os sintomas são relacionados diretamente ao tamanho, ao número e à localização dos miomas. Nessa revisão, são apresentadas as abordagens terapêuticas atuais clínicas (anticoncepcionais orais, progestágenos e antiprogestágenos, análogos do hormônio liberador das gonadotrofinas (GnRH, e antiinflamatórios não esteróides e cirúrgicas (histerectomia, miomectomia e embolização para o tratamento de leiomiomas.Leiomyomas are benign tumors. They appear in the myometrium and present a variable amount of fibrous conjunctive tissue. About 75% of the cases are not symptomatic and are usually found during abdominal, bimanual pelvic examination or during ultrasonography. The symptoms are directly related to the size, number and localization of the myomas. In the present review, the current clinical therapeutic procedures (oral anti-conceptive drugs, progestins and anti-progestins, analogues of the gonadothrophins’ releasing hormone (GnRH, and non-steroid anti-inflammatory drugs, and also the surgical procedures (hysterectomy, myomectomy, embolization are presented for the treatment of leiomyomas.

  8. Orbital Tumors and Pseudotumors

    OpenAIRE

    Talan-Hranilović, Jasna; Tomas, Davor

    2004-01-01

    Twenty-four orbital tumors and 4 pseudotumors diagnosed in biopsy material among 596 ophthalmic tumors examined during the 1998-2003 period are presented according to patient age and sex, tumor histology and immunohistochemistry. The most common orbital tumors were lipomas, meningiomas and lymphomas, with a peak incidence in the seventh decade of life. Most orbital tumors of childhood are distinguished from those occurring in adults. Most pediatric orbital tumors are benign (developmental cys...

  9. Tumores colorretais hereditários Hereditary colorectal tumors

    OpenAIRE

    Benedito Mauro Rossi; Mauro de Souza Leite Pinho; Wilson Toshihiko Nakagawa; Luis Fernando Pinto Johnson; Ademar Lopes

    1998-01-01

    Cerca de 4% a 15% dos tumores colorretais são hereditários e divididos em dois grupos: polipose adenomatosa familiar (FAP) e câncer colorretal hereditário sem polipose (HNPCC). Ambas são doenças autossômicas dominantes, com transmissão vertical, geração após geração, sem preferência por sexo. A FAP tem penetrância praticamente completa, caracterizada por mais de cem pólipos adenomatosos no intestino grosso, que aparecem em geral após a puberdade e se transformam em câncer em todos os casos nã...

  10. Valor da ressonância magnética no planejamento radioterápico dos tumores de colo de útero: resultados preliminares Value of magnetic resonance imaging in the radiotherapy planning of tumours of the uterine cervix: preliminary results

    Directory of Open Access Journals (Sweden)

    Pitágoras Baskara Justino

    2005-12-01

    Full Text Available OBJETIVO: Verificar o índice de erros geográficos no planejamento radioterápico convencional de pacientes com carcinoma de colo uterino por meio da ressonância magnética. MATERIAIS E MÉTODOS: Trinta e duas pacientes com diagnóstico histológico de carcinoma espinocelular de colo uterino, com indicação de radioterapia, foram analisadas. Foi realizada ressonância magnética da pelve, sendo essas imagens comparadas aos campos clássicos de radioterapia, técnica de quatro campos em "tijolo". Considerou-se erro geográfico quando o volume alvo não foi englobado pelos campos, com margens mínimas de 1 cm. RESULTADOS: Em 24 pacientes (75% foi detectada possibilidade de erro geográfico se fossem utilizados os campos convencionais. Em todos os casos o erro foi à custa dos limites anterior (46% ou posterior (40% dos campos laterais. CONCLUSÃO: A ressonância magnética evidenciou chance elevada de erro geográfico no planejamento radioterápico convencional na população analisada, tanto nas pacientes com doença em estádios iniciais quanto avançados.OBJECTIVE: To assess the rate of geographic miss on conventional radiotherapy planning of patients with cervical cancer, using magnetic resonance imaging. MATERIALS AND METHODS: Thirty-two patients with squamous cell carcinoma of the uterine cervix were studied. Magnetic resonance imaging of the pelvis was performed after clinical staging. Magnetic resonance imaging findings were compared with the classic fields described for the "box" technique. Target volume within less than 1 cm margins of the fields' limits was considered as geographic miss. RESULTS: Classical radiation field limits were inadequate in 24 cases (75%, all in the anterior (46% or posterior (40% border of the lateral fields. CONCLUSION: Magnetic resonance detected a high probability of geographic miss on conventional radiotherapy planning in this population, both in initial and advanced stages of the disease.

  11. Radiological diagnostics of skeletal tumors

    International Nuclear Information System (INIS)

    The book contains contributions concerning the following topics: 1. introduction and fundamentals: WHO classification of bone tumors, imaging diagnostics and their function; localization, typical clinical and radiological criteria, TNM classification and status classification, invasive tumor diagnostics; 2. specific tumor diagnostics: chondrogenic bone tumors, osseous tumors, connective tissue bony tumors, osteoclastoma, osteomyelogenic bone tumors, vascular bone tumors, neurogenic bone tumors, chordoma; adamantinoma of the long tubular bone; tumor-like lesions, bony metastases, bone granulomas, differential diagnostics: tumor-like lesions

  12. Tumor heterogeneity, tumor size, and radioresistance

    International Nuclear Information System (INIS)

    Mutant clonogenic cells, resistant to individual chemotherapeutic agents, are known to play a central role in clinical chemotherapy failure. The possibility that mutant cells, resistant to conventionally fractionated megavoltage photon radiotherapy, exist in human tumors is considered. Applying the mutation theory of Luria and Delbruck to describe the appearance of resistant cells, several conclusions follow: (a) the mean number of resistant cells in a tumor will be determined by the tumor size and the mutation rate; (b) a wide variation in radiosensitivity in tumors of the same histology is expected, because of a large variation in the number of resistant cells that they contain; (c) the presence of a resistant clone will not reduce the tumor-control probability until the tumor becomes sufficiently large; (d) initial response will not be a reliable predictor of long-term control; (e) clonogenic assays may not accurately predict treatment outcomes; (f) the mutation rate may be the most accurate predictor of tumor aggressiveness and resistance to various treatment modalities; (g) tumors with a low mutation rate, which may include seminoma, Hodgkin's disease and many pediatric tumors would be curable by either chemotherapy or radiation; (h) pleomorphic tumors with a high mutation rate, which may include glioblastoma multiforme, would be difficult to cure by any means. Clinical and experimental evidence is reviewed for the existence of radioresistant cell lines in human and animal tumors, and further experiments are proposed to test this hypothesis. Treatment strategies for targeting radioresistant clones are discussed

  13. Comparação entre o pencil beam convolution algorithm e o analytical anisotropic algorithm em tumores de mama

    OpenAIRE

    Sá, Ana Cravo; Coelho, Carina Marques; Monsanto, Fátima

    2014-01-01

    Objectivo do estudo: comparar o desempenho dos algoritmos Pencil Beam Convolution (PBC) e do Analytical Anisotropic Algorithm (AAA) no planeamento do tratamento de tumores de mama com radioterapia conformacional a 3D.

  14. Pediatric Odontogenic Tumors.

    Science.gov (United States)

    Abrahams, Joshua M; McClure, Shawn A

    2016-02-01

    Pediatric odontogenic tumors are rare, and are often associated with impacted teeth. Although they can develop anywhere in the jaws, odontogenic tumors mainly occur in the posterior mandible. This article discusses the diagnosis and treatment of the most common pediatric odontogenic tumors, such as ameloblastoma, keratocystic odontogenic tumor, odontoma, and cementoblastoma. PMID:26614700

  15. Updates in Orbital Tumors

    Institute of Scientific and Technical Information of China (English)

    Nila; F.Moeloek

    1993-01-01

    Orbital anatomy, the clinical features of orbital tumors, the recent development of the diagnosis and management of orbital tumors were described. The incidence of orbital tumors in Dr. Cipto Mangunkusumo Hospital in the past years were introduced. The principle of management of orbital tumors and their prognosis were discussed.

  16. Evaluation of doses from radiodiagnostic procedures performed in veterinary medicine and assessing of the doses of secondary radiation in the medical staff and animal owners; Avaliacao das doses resultantes de procedimentos radiodiagnosticos realizados em medicina veterinaria e avaliacao das doses secundarias de radiacao espalhada no corpo clinico e nos proprietarios dos animais

    Energy Technology Data Exchange (ETDEWEB)

    Veneziani, Glauco Rogerio

    2012-07-01

    The primary goal in veterinary radiography is to produce radiographs of diagnostic quality on the first attempt. This goal serves three purposes: (1) to decrease radiation exposure to the patient and veterinary personnel; (2) to decrease the cost of the study for the client; and (3) to produce diagnostic data for rapid interpretation and treatment of the patient. This work aimed to determine the doses in dogs submitted to chest and abdomen X rays using the technique of thermoluminescence (TL) dosimetry. The radiation doses were assessed using thermoluminescent dosimeters of calcium sulphate doped with dysprosium (CaSO{sub 4}:Dy) and lithium fluoride doped with magnesium and titanium (LiF:Mg,Ti). The obtained results indicate that is extremely important the assessment of radiation doses involved in veterinary diagnostic radiology procedures, to evaluate the delivered doses to the animals, to be used as a parameter in the individual monitoring of pet's owners, who assist the animal positioning, and to protect occupationally exposed workers at the Veterinary Radiology Clinics. (author)

  17. Supratentorial tumors; Supratentorielle Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.; Dillmann, K.; Roth, C.; Backens, M.; Reith, W. [Universitaetsklinikum Saarland, Homburg (Germany). Klinik fuer Diagnostische und Interventionelle Neuroradiologie

    2007-06-15

    Magnetic resonance imaging is a routine diagnostic measure for a suspected intracerebral mass. Computed tomography is usually also indicated. Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location. This contribution discusses the symptoms and diagnostics for supratentorial tumors separated in relation to their intra- or extracranial location. Supratentorial tumors include astrocytoma, differentiated by their circumscribed and diffuse growth, ganglioglioma, ependyoma, neurocytoma, primitive neuroectodermal tumors (PNET), oligodendroglioma, dysembryoplastic neuroepithelial tumors (DNET), meningoangiomatosis, pineal tumors, hamartoma, lymphoma, craniopharyngeoma and metastases. The supratentorial extracranial tumors include the choroid plexus, colloid cysts, meningeoma, infantile myofibromatosis and lipoma. The most common subforms, especially of astrocytoma, will also be presented. (orig.)

  18. Tumor heterogeneity and circulating tumor cells.

    Science.gov (United States)

    Zhang, Chufeng; Guan, Yan; Sun, Yulan; Ai, Dan; Guo, Qisen

    2016-05-01

    In patients with cancer, individualized treatment strategies are generally guided by an analysis of molecular biomarkers. However, genetic instability allows tumor cells to lose monoclonality and acquire genetic heterogeneity, an important characteristic of tumors, during disease progression. Researchers have found that there is tumor heterogeneity between the primary tumor and metastatic lesions, between different metastatic lesions, and even within a single tumor (either primary or metastatic). Tumor heterogeneity is associated with heterogeneous protein functions, which lowers diagnostic precision and consequently becomes an obstacle to determining the appropriate therapeutic strategies for individual cancer patients. With the development of novel testing technologies, an increasing number of studies have attempted to explore tumor heterogeneity by examining circulating tumor cells (CTCs), with the expectation that CTCs may comprehensively represent the full spectrum of mutations and/or protein expression alterations present in the cancer. In addition, this strategy represents a minimally invasive approach compared to traditional tissue biopsies that can be used to dynamically monitor tumor evolution. The present article reviews the potential efficacy of using CTCs to identify both spatial and temporal tumor heterogeneity. This review also highlights current issues in this field and provides an outlook toward future applications of CTCs. PMID:26902424

  19. Endocrine tumors other than thyroid tumors

    International Nuclear Information System (INIS)

    This paper discusses the tendency for the occurrence of tumors in the endocrine glands, other than the thyroid gland, in A-bomb survivors using both autopsy and clinical data. ABCC-RERF sample data using 4136 autopsy cases (1961-1977) revealed parathyroid tumors in 13 A-bomb survivors, including 3 with the associated hyperparathyroidism, with the suggestion of dose-dependent increase in the occurrence of tumors. Based on clinical data from Hiroshima University, 7 (46.7%) of 15 parathyroid tumors cases were A-bomb survivors. Data (1974-1987) from the Tumor Registry Committee (TRC) in Hiroshima Prefecture revealed that a relative risk of parathyroid tumors was 5.6 times higher in the entire group of A-bomb survivors and 16.2 times higher in the group of heavily exposed A-bomb survivors, suggesting the dose-dependent increase in their occurrence. Adrenal tumors were detected in 47 of 123 cases from the TRC data, and 15 (31.5%) of these 47 were A-bomb survivors. Particularly, 11 cases of adrenal tumors associated with Cushing syndrome included 6 A-bomb survivors (54.5%). The incidence of multiple endocrine gonadial tumors (MEGT) tended to be higher with increasing exposure doses; and the 1-9 rad group, the 10-99 rad group, and the 100 or more rad group had a risk of developing MEGT of 4.1, 5.7, and 7.1, respectively, relative to both the not-in the city group and the 0 rad group. These findings suggested that there is a correlation between A-bomb radiation and the occurrence of parathyroid tumors (including hyperparathyroidism), adrenal tumors associated with Cushing syndrome and MEGT (especially, the combined thyroid and ovarian tumors and the combined thyroid and parathyroid tumors). (N.K.)

  20. Imaging the Tumor Microenvironment

    OpenAIRE

    LeBleu, Valerie

    2015-01-01

    The tumor microenvironment is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the tumor microenvironment are under active development and currently used modalities and novel approaches are summarized here. Understanding the dynamic and evolving functions of the tumor microenvironment is critical to accurately inform imaging and clinical care of cancer. Novel insights into distinct roles of the tumor microenvironment...

  1. Tumores colorretais hereditários Hereditary colorectal tumors

    Directory of Open Access Journals (Sweden)

    Benedito Mauro Rossi

    1998-08-01

    Full Text Available Cerca de 4% a 15% dos tumores colorretais são hereditários e divididos em dois grupos: polipose adenomatosa familiar (FAP e câncer colorretal hereditário sem polipose (HNPCC. Ambas são doenças autossômicas dominantes, com transmissão vertical, geração após geração, sem preferência por sexo. A FAP tem penetrância praticamente completa, caracterizada por mais de cem pólipos adenomatosos no intestino grosso, que aparecem em geral após a puberdade e se transformam em câncer em todos os casos não tratados, levando o paciente ao óbito em tomo dos 45 anos de idade. Manifestações extracolônicas são comuns, tais como: pólipos em estômago e duodeno, sarcomas abdominais, pigmentação de retina, osteomas, entre outras. A FAP é causada por mutação no gene APC, que está localizado no cromossomo 5q. Seu tratamento é basicamente cirúrgico, com retirada do intestino grosso, podendo-se preservar o reto, se este não apresentar muitos pólipos. O HNPCC tem penetrância em torno de 80% e não apresenta os pólipos benignos como na FAP, que permitem identificar pacientes com o fenótipo da doença. Geralmente, o diagnóstico da lesão colônica é realizado já na fase maligna, em torno dos 45 anos de idade, com preferência para o lado direito do cólon. Pode haver associação com tumores de endométrio na mulher, estômago, pâncreas, entre outros. É causada por mutação em genes de reparo do DNA (hMSH2, hMLH1, hPMS1, hPMS2, hMSH6/GTBP. A colectomia total deve ser realizada em pacientes com câncer de cólon e HNPCC. Se o tumor estiver localizado no reto, a proctocolectomia total pode ser uma opção. Em indivíduos portadores do defeito genético predisponente ao HNPCC, porém, assintomáticos, a indicação de cirurgias profiláticas é controversa. Atualmente, podem-se identificar indivíduos portadores de defeito genético herdado tanto na FAP como no HNPCC. Esses testes baseiam-se no estudo direto dos genes respons

  2. Evaluation of conformal radiotherapy techniques through physics and biologic criteria; Avaliacao de tecnicas radioterapicas conformacionais utilizando criterios fisicos e biologicos

    Energy Technology Data Exchange (ETDEWEB)

    Bloch, Jonatas Carrero

    2012-07-01

    In the fight against cancer, different irradiation techniques have been developed based on technological advances and aiming to optimize the elimination of tumor cells with the lowest damage to healthy tissues. The radiotherapy planning goal is to establish irradiation technical parameters in order to achieve the prescribed dose distribution over the treatment volumes. While dose prescription is based on radiosensitivity of the irradiated tissues, the physical calculations on treatment planning take into account dosimetric parameters related to the radiation beam and the physical characteristics of the irradiated tissues. To incorporate tissue's radiosensitivity into radiotherapy planning calculations can help particularize treatments and establish criteria to compare and elect radiation techniques, contributing to the tumor control and the success of the treatment. Accordingly, biological models of cellular response to radiation have to be well established. This work aimed to study the applicability of using biological models in radiotherapy planning calculations to aid evaluating radiotherapy techniques. Tumor control probability (TCP) was studied for two formulations of the linear-quadratic model, with and without repopulation, as a function of planning parameters, as dose per fraction, and of radiobiological parameters, as the α/β ratio. Besides, the usage of biological criteria to compare radiotherapy techniques was tested using a prostate planning simulated with Monte Carlo code PENELOPE. Afterwards, prostate planning for five patients from the Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, USP, using three different techniques were compared using the tumor control probability. In that order, dose matrices from the XiO treatment planning system were converted to TCP distributions and TCP-volume histograms. The studies performed allow the conclusions that radiobiological parameters can significantly influence tumor control

  3. Manual dos chefes de missão dos CONs: Rio 2016 : Abril 2016

    OpenAIRE

    2016-01-01

    Publicado em abril de 2016, o « Manual dos chefes de missão » oferece aos CONs uma visão detalhada dos serviços disponíveis durante os Jogos Olímpicos Rio 2016, assim como das operações durante os Jogos.

  4. Contabilidade criativa e responsabilidade dos auditores

    OpenAIRE

    Ariovaldo dos Santos; Ivan Ricardo Guevara Grateron

    2003-01-01

    Nos contextos nacional e internacional da profissão contábil, o auditor tem exercido um papel fundamental. A atividade profissional do auditor independente tem ajudado a impulsionar o desenvolvimento dos mercados, além de contribuir para o estabelecimento da ordem socioeconômica mundial. Na visão dos usuários externos da informação contábil, e dos próprios clientes, a atuação do auditor é sinônimo de confiança e credibilidade. Nos últimos meses, a onda de escândalos contábeis, com grandes emp...

  5. O “paradoxo dos fumadores” revisitado.

    OpenAIRE

    A Gaspar; Nabais, S; Torres, M.; S. Rocha; Brandão, A; Azevedo, P; Álvares-Pereira, M; Correia, A

    2008-01-01

    Introdução: O termo “paradoxo dos fumadores” surgiu na sequência de vários estudos que descreveram uma menor mortalidade a curto prazo nos doentes com história de tabagismo, internados com Síndrome Coronário Agudo (SCA). No entanto, trabalhos mais recentes têm contestado a existência deste fenómeno. Objectivo: Avaliar a ocorrência do “paradoxo dos fumadores” na nossa população de doentes internados por SCA. Métodos: Foram analisados 1228 doentes admitidos consecutivamente por SCA de Jan...

  6. Conhecimento sobre sida e sexualidade dos adolescentes

    OpenAIRE

    Bento, Ermelinda Manuela Teixeira; Ferreira, Manuela Maria Conceição; Chaves, Cláudia Margarida Correia Balula; Duarte, João Carvalho

    2013-01-01

    A Síndrome de Imunodeficiência Adquirida (SIDA) assume-se como o mais grave problema de saúde pública da era moderna, apelidada pela OMS como a Primeira Crise Mundial da Saúde é uma doença que transpõe a sua índole de patologia do sistema imunitário anunciando-se como uma doença social, de índole comportamental que tem nos adolescentes um dos grupos de maior vulnerabilidade. De acordo com os dados da UNAIDS (2012), o grupo etário dos 15 aos 24 anos representa o agregado de maio...

  7. La larga vida de dos rocas orensanas

    OpenAIRE

    García Quintela, Marco V.; Seoane-Veiga, Yolanda

    2011-01-01

    [ES] Se estudian dos rocas, un petroglifo y un «santuario rupestre » de la provincia de Ourense, con dos metodologías complementarias, la arqueología del paisaje y la «biografía» (Kopytoff) de los objetos. Partiendo de su descripción en textos cristianos se considera el patrón de localización que conforman en relación con castros importantes, relación que se propone fechar en la Edad del Hierro. Esta adscripción cronocultural y su posterior resemantización cristiana lleva a la consideración d...

  8. Synchronous subungual glomus tumors in the same finger Tumores glômicos subungueais sincrônicos no mesmo dedo

    OpenAIRE

    Nilton Di Chiacchio; Walter Refkalefsky Loureiro; Nilton Gioia Di Chiacchio; Diego Leonardo Bet

    2012-01-01

    The glomus tumor is an uncommon benign neoplasm of glomus cells. In the majority of the cases it is presented as a solitary painful papule in the subungual region. We report a rare case of a patient with two individual synchronous glomus tumors under the nail bed of the same finger.O tumor glômico é uma neoplasia benigna de células glômicas. Na maioria dos casos se apresenta como uma pápula solitária dolorosa na região subungueal. Relatamos o caso raro de um paciente com dois tumores glômicos...

  9. Computed tomography prospective study of pleural-pulmonary changes after abdominal surgery : assessment of associated risk factors; Estudo prospectivo por tomografia computadorizada das alteracoes pleuro-pulmonares apos cirurgia abdominal: avaliacao dos fatores de risco associados

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, Luis Antonio [Pontificia Univ. Catolica de Sao Paulo, SP (Brazil). Centro de Ciencias Medicas e Biologicas]. E-mail: luizrossimd@uol.com.br; Bromberg, Sansom Henrique [Instituto de Assistencia Medica ao Servidor Publico Estadual de Sao Paulo (IAMSPE), Sao Paulo, SP (Brazil). Curso de Pos-graduacao em Gastroenterologia Cirurgica

    2005-07-01

    Postoperative pleural-pulmonary changes (PPC) are very common following elective abdominal surgery, resolving without clinical manifestations in most patients. The incidence and risk factors associated are unknown. Objective: to determine the incidence of PPC and possible association with risk factors using computerized tomography (CT). Material and method: thirty seven patients submitted to elective abdominal surgery were prospectively analyzed using CT performed in the preoperative period and 48 hours after surgery. The PPC was scored from 0 to III. The risk factors evaluated were: age, sex, obesity, smoking history, alcoholism, comorbid conditions, cancer, ASA classification, duration of surgery, surgical incision type and number of days of hospitalization. Results: Pleura effusion was detected by CT in 70.3% (26/37) of the patients and pulmonary atelectasis in 75.5% (28/37). Grade I and II PPC was found in 59.5% (22/37) of the patients and grade III in 21.6% (8/37). Two (5.4%) of these patients developed serious pulmonary complications whereas one patient died. Surgery due to cancer, class ASA >2, longitudinal incision and > 15 cm showed statistical significance and were associated with pleural effusion. The hospitalization was over 2.4 longer for patients with PPC. Conclusion: PPC is frequently seen in patients submitted to abdominal surgery. The use of the CT for the detection of pulmonary atelectasis and pleural effusion proved to be effective. Most cases of PPC are self-limited, resolving without symptoms. (author)

  10. Evaluation of the social and economical impacts related to the large scale production of bioethanol in Brazil; Avaliacao dos impactos socioeconomicos relacionados a producao em larga escala do bioetanol no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    The social and economical impacts related to the large scale bio ethanol production have been evaluated considering the replacement of 10% of gasoline equivalent consumption in the world forecasting for the year 2025, evaluating the impacts not only in the sectors directly involved (bio ethanol and sugar cane production), but also taking into account the effects on all production chain of the economy (direct, indirect and induced effects). For this analysis, an income-product model was developed allowing to simulate production gains during the agricultural phase, and to combine different technologies for the production of bio ethanol, for quantification the impacts of the forwarding the second generation technology.

  11. Assessment of the occupational exposure of the workers involved in the {sup 123}I production at the IEN/CNEN-RJ; Avaliacao da exposicao ocupacional dos trabalhadores envolvidos na producao de {sup 123}I no IEN

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Francisco de

    2005-07-01

    {sup 123}I is a gamma emitter used for diagnosis in Nuclear Medicine. Since 1998 it is produced in the Institute of Nuclear Energy (IEN) and supplied to the Clinics and Hospitals located in the city of Rio de Janeiro. The annual production is in the approximately of 0,74 TBq (20 Ci), which represents a risk of external and internal exposure to the workers involved in this activity. A survey of external doses in the period of 1994 to 2004 was carried out based on the individual registries available in the CONEXO Data Base operated by the Institute of Radiation Protection and Dosimetry (IRD). It was verified an increase of the external exposure associated to the production curve. However, the individual doses are all bellow the annual limits established by the regulatory board. On the other hand, the variation of doses among individuals involved in the same tasks suggests the possibility of optimization of procedures. Regarding internal exposure it was calculated a decision factor above 1mSv for the practice, which justifies the need for internal monitoring. An evaluation of the process based on the results of in vivo thyroid monitoring in the period of 2000 to 2004 was carried out to identify the steps which represent higher risk of internal exposure. The available data indicate that the laboratory of quality control is the critical step in terms of internal contamination. This conclusion can be justified by the high volatility of iodine which is manipulated in the form of a liquid open source during this step. With the aim of optimizing monitoring procedures for the control of occupationally exposed workers in the production of {sup 123}I, in vivo and in vitro bioassay methods were developed to identify and quantify internal contamination by such radionuclide, using the detection systems available at the Bioassay Laboratory and at the In Vivo Measurements Laboratory. The techniques developed present sensitivity compatible with the derived registry level associated to the committed effective dose equivalent of 1mSv. It was also established a methodology for the interpretation of bioassay data using the software AIDE. The methods developed in this work can be used to implement improvements in the radiation protection program of the IEN. It is suggested to increase the frequency of in vivo measurements and to include in vitro bioassay in the monitoring program, which will permit a better evaluation of the internal doses of the workers(author)

  12. Hemocyte characterization of Nasutitermes coxipoensis (Holmgren) (Isoptera: Termitidae) workers and hemocyte evaluation after parasitism by Metarhizium anisopliae; Caracterizacao dos hemocitos de operarios de Nasutitermes coxipoensis (Holmgren) (Isoptera: Termitidae) e avaliacao hemocitaria apos parasitismo por Metarhizium anisopliae

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Franklin M.; Wanderley-Teixeira, Valeria; Albuquerque, Auristela C. [Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE (Brazil). Programa de Pos-Graduacao em Entomologia Agricola], e-mail: ukento@yahoo.com.br; Teixeira, Alvaro A.C. [Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE (Brazil). Dept. de Morfologia e Fisiologia Animal], e-mail: valeria@dmfa.ufrpe.br, e-mail: auritermes@yahoo.com.br; Alves, Luiz C. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Lab. de Imunopatologia Keizo Asami (LIKA); Lima, Elza A.L.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Micologia. Lab. de Controle Biologico

    2009-03-15

    We aimed to characterize the morphology and ultrastructure of hemocytes of Nasutitermes coxipoensis (Holmgren) workers and to quantify the cell types 24h, 48h and 72h after inoculation with Metarhizium anisopliae. Six hemocytes types were identified, plasmatocyte, granulocyte, spherulocyte, prohemocyte, adipohemocyte and eonocytoid Hemocytes did not present any morphological alteration at the several observation periods, but they did have a change in their abundance, as observed for spherulocytes, adipohemocytes and eonocytoids at all intervals, and for plasmatocytes and granulocytes at 48h after host inoculation. We argue on the possible reasons and implications of the observed changes. (author)

  13. Evaluation of radon concentration in dwellings and well water of Parana State-Brazil; Avaliacao dos niveis de concentracao de radonio em ambientes e aguas de pocos no Estado do Parana

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Janine Nicolosi

    2011-07-01

    Considering the growing interest of International Agencies and national Governmental organs in studies and measurements of radon activity in air, soil gas and ground water (mainly from artesian wells) as well as scarceness of such measurements at Brazilian territory, present studies were initiated by the Laboratory of Applied Nuclear Physics of Federal University of Technology - Parana (UTFPR) in collaboration with the Institute of Radiation Protection and Dosimetry (IRD) and the Center of Nuclear Technology Development (CDTN) of Brazilian Commission on Nuclear Energy (CNEN). This Collaboration started in 2003. Radon monitoring program is based mainly on use of Solid State Nuclear Track Detectors for radon activity measurements in air. Continuous electronic radon detectors are used for radon measurements in soil gas and water. Current work presents the results of indoor {sup 222}Rn activity of dwellings and working places of Curitiba-PR and radon concentration in ground water samples from artesian wells from aquifers of the same area. The indoor measurements of radon activity were performed using Solid State Nuclear Track Detectors CR-39. After the exposition, CR-39 detectors were submitted to chemical development which permitted to make alpha particle tracks counting. The results of calibration of CR-39 together with efficiency of used exhalation chambers as well as alpha particle tracks chemical development procedure were performed in cooperation with CDTN and collaboration with the National Institute of Radiological Sciences (NIRS). The major part of indoor {sup 222}Rn concentration in residences was found below 100 Bq/m3. In the case of working places, all measurements present {sup 222}Rn concentration bellow 100 Bq/m3. The studies of radon activity in water were performed using the samples of water from artesian wells submitted to recursive measurements by instant radon detector AlphaGUARD PQ2000 PRO during few weeks with intervals of about 4 days between each measurement approximately. The calculations of initial radon activity in water were done considering the {sup 222}Rn decay correction as well as equilibrium level of {sup 222}Rn and {sup 226}Ra observed after 30 days of measurements. Obtained results show that about 70% measured activity levels of {sup 222}Rn are higher than recommended value of 11.1 Bq/L which represent the risk for the human health associated with this radionuclide.

  14. Dyes removal of textile wastewater onto surfactant modified zeolite from coal ash and evaluation of the toxic effects; Remocao de corantes de efluente textil por zeolita de cinzas de carvao modificada por surfactante e avaliacao dos efeitos toxicos

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Patricia Cunico

    2015-07-01

    Zeolites synthesized from fly and bottom ashes and modified with hexadecyltrimethylammonium (HDTMA) were used as adsorbent to remove dyes - Solophenyl Navy (SN) and Solophenyl Turquoise (ST) and their hydrolysed forms Solophenyl Navy Hydrolysed (SNH) and Solophenyl Turquoise Hydrolysed (STH), from simulated textile wastewater. The HDTMA-modified fly zeolite (ZMF) and HDTMA-modified bottom zeolite (ZMB) were characterized by different techniques, as X-ray fluorescence spectrometry, X-ray diffraction and scanning electron microscopy, etc. The ZMF and ZMB presented negative charge probably due to the formation of a partial bilayer of HDTMA on exchangeable active sites on the external surface of unmodified zeolite. Initial dye concentration, contact time and equilibrium adsorption were evaluated. The adsorption kinetic for SN, ST, SNH and STH onto the zeolites followed the pseudo second-order model. The equilibrium time was 20 min for SN and ST and 30 min for SNH and STH, respectively. Langmuir, Freundlich and Temkin models were applied to describe the adsorption isotherms. Adsorption of the dyes were best described by the Langmuir model, with exception to SN/ZPM, SNH/ZPM and SNH/ZLM systems that followed Freundlich model. The maximum adsorption capacities were 3,64; 3,57; 2,91 e 4,93 for SN, ST, SNH e STH by ZLM, respectively and 0,235; 0,492; 1,26 e 1,86 by ZPM, in this order. The best performance for hydrolyzed dyes has been attributed to reduction of the size of dyes molecules during the hydrolysis process. Acute toxicity of the dyes to a different organism were evaluated by different test-organisms. Waterflea, Ceriodaphnia dubia showed EC50 value of 1,25; 54,5; 0,78 and 2,56 mgL{sup -1} for SN, ST, SNH and STH, respectively. The plant Lemna minor showed EC50 values of 18,9; 69,4; 10,9 and 70,9 mgL{sup -1} for SN, ST, SNH and STH, respectively. Midges larvae of Chironomus tepperi showed EC50 values of 119 and 440 mgL{sup -1} for SN and ST, respectively. Regarding the adsorption process, acute effects were substantially reduced after adsorption treatment of aqueous solution with SN and ST by ZMF, as well as their hydrolysed forms, showing no toxicity after removal of 100% of colour. After treatment with ZPM there was an increase of the toxicity, with exception of SHN and STH dyes that do not show toxicity after the treatment. Toxicity Identification Evaluation tests (TIE) were realized in order to identify what substances were causing the observed toxicity for the SN, ST and the leached of ZMF and ZMB. The acute effects were significantly reduced after manipulation with Solid-Phase Extraction (SPE) and Ethylenediaminetetraacetic acid (EDTA) for the leached of ZMB and ZMF. The dyes showed reduced in the toxicity after manipulation with EDTA indicating that the toxicants are mostly cationic metals. (author)

  15. An evaluation of the participation of the social movements on the decision making process and planning of the electric sector; Uma avaliacao da participacao dos movimentos sociais no planejamento e no processo decisorio do setor eletrico

    Energy Technology Data Exchange (ETDEWEB)

    Moral Hernandez, Francisco del; Bermann, Celio [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Eletrotecnica e Energia. Programa Interunidades de Pos-graduacao em Energia]. E-mail: delmoral@hotmail.com; cbermann@iee.usp.br

    2006-07-01

    This work presents some reflexions on the possibility of a public sphere in the decision making process in the energetic sector. By using the conceptual mark of Juergen HABERMAS, some reflexions on the political participation specificities at Latin America, mainly those ones suggested by AVRITZER (2002) and the theoretical reflexions of HONNETH (2003) recognition fight and construction in the social movements, the work tries the verification of how far the requirements of social organizations identified in this work are from a desirable situation, or else a more effective participation of the social movements on the decisions and planning spaces and the deliberative character of the public discussion space in the area of energy.

  16. Evaluation of the effects of gamma radiation on physicochemical characteristics of kiwi (Actinidia deliciosa) cv. Hayward minimally processed; Avaliacao dos efeitos da radiacao gama nas caracteristicas fisico-quimicas de kiwi (Actinidia deliciosa) cv. Hayward minimamente processado

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Ana Claudia Sampaio

    2011-07-01

    The search for a healthy life has led consumers to rethink their eating habits, consuming fruits and vegetables in place of manufactured products, therefore, the demand for minimally processed products has evolved rapidly. The kiwi fruit (Actinidia deliciosa) has high nutritional value, being rich in C vitamin especially, which has wide acceptance in consumer markets. Thus, along with papaya, passion fruit and pineapple, kiwi can be considered as an additional feature of C vitamin in the diet, or as a substitute for traditional citrus. The aim of this study was to assess the effects of gamma radiation on physical and chemical characteristics of kiwis minimally processed and stored under refrigeration, since this technology increases the shelf life of fruits and vegetables. The Kiwis was stripped, processed and cut into slices, stored in polyethylene bags of 10 cm squared and irradiated at doses of 0 (control), 1 and 2 kGy. A source of {sup 60}Co Gammacell 220, dose rate of 0.429 kGy/hour, in which each treatment had 5 replicates with 15 slices of kiwifruit per replicate. After irradiation the samples were stored in a climatic chamber at 6 degree C (near the temperature of commercial refrigerators). The following criteria were physical chemical analysis: pH, color, chlorophyll content, loss of weight, moisture, acidity and Brix. The analysis were done on 1{sup st}, 7{sup th} and 14{sup th} days after irradiation. The results indicated that gamma radiation did not induce deleterious changes in the physicochemical properties of the kiwi may be used for preservation of minimally processed kiwifruit. (author)

  17. Evaluation of area monitor response for neutrons in radiation field generated by a 15 MV clinic accelerator; Avaliacao da resposta dos monitores de area para neutrons em campo de radiacao gerado por um acelerador clinico de 15 MV

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, Ana Paula

    2011-07-01

    The clinical importance and usage of linear accelerators in cancer treatment increased significantly in the last years. Coupled with this growth came the concern about the use of accelerators with energies over to 10 MeV which produce therapeutic beam contaminated with neutrons generated when high-energy photons interact with high-atomic-number materials such as tungsten and lead present in the accelerator itself. At these facilities, measurements of the ambient dose equivalent for neutrons present difficulties owing to the existence of a mixed radiation field and possible electromagnetic interference near the accelerator. The Neutron Laboratory of the IRD - Brazilian Institute for Radioprotection and Dosimetry, aiming to evaluate the survey meters performance at these facilities, initiated studies of instrumentation response in the presence of different neutron spectra. Neutrons sources with average energies ranging from 0.55 to 4.2 MeV, four different survey meters and one ionization chamber to obtain the ratio between the dose due to neutrons and gamma radiation were used in this work. The evaluation of these measurements, performed in a 15 MV linear accelerator room is presented. This work presents results that demonstrate the complexity and care needed to make neutrons measurements in radiotherapy treatment rooms containing high energy clinical accelerators. (author)

  18. Evaluation of the dosimetric pens calibration performed at the Laboratory of Ionizing Radiation Metrology, IRD/CNEN, Brazil; Avaliacao dos resultados de calibracao de canetas dosimetricas realizada no Laboratorio Nacional de Metrologia das Radiacoes Ionizantes

    Energy Technology Data Exchange (ETDEWEB)

    Quaresma, D.S.; Ramos, M.M.O.; Cabral, T.S.; Peixoto, J.G.P. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)]. E-mail: dansq@ird.gov.br

    2005-03-15

    This article compares the behavior of measurements performed by using dosimetric pens from different models and manufacturers, submitted to calibration at the Metrology Brazilian National Laboratory for Ionizing Radiations, IRD/CNEN, during the period of 2000-2002. The considered parameters were the accuracy, the response linearity and the measurement uncertainty evaluated. The results demonstrate that among the analysed models there are behaviour variations.

  19. Use of the HRICP-MS technique for the evaluation of boron isotopes in Eucalitpus plants; Uso da tecnica HRICP-MS na avaliacao dos isotopos de boro em eucalipto

    Energy Technology Data Exchange (ETDEWEB)

    Mattiello, Edson Marcio; Ruiz, Hugo Alberto; Silva, Ivo Ribeiro da, E-mail: mattiello@ufv.b [Universidade Federal de Vicosa (UFV), MG (Brazil). Dept. de Solos; Sarkis, Jorge Eduardo de Souza [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    The {sup 10}B isotope tracer technique is essential to study the B mobility in plants. Factors that can influence the quality of measured B isotope ratios were optimized experimentally using High Resolution Inductively Coupled Plasma Mass Spectrometry (HRICP-MS). An isotopically certified standard (NIST SRM-951) was used. The best combination was obtained using a resolution of 400, a RF power of 1250 W, followed by 15 measurements over a 10-s integration period each (15*10). Utilizing this approach it was possible to obtain a precision of 0.3 % in standard material and 2z % in the experimental samples. The results show the importance of establishing optimized work conditions before carrying out the analytical series. (author)

  20. Irradiation effects of GaAlAs ({lambda}=830 nm) laser on oral traumatic ulceration; Avaliacao dos efeitos da irradiacao de ulceras traumaticas na cavidade bucal com o laser de GaAlAs ({lambda}=830 nm)

    Energy Technology Data Exchange (ETDEWEB)

    Senna, Andre Machado de

    2003-07-01

    Low intensity GaAlAs ({lambda}=830 nm) laser irradiation effects on oral traumatic ulceration were evaluated. For this purpose, twenty patients presenting orthodontic appliance - induced oral traumatic ulceration were randomly distributed in two groups. Patients in group 1 were submitted to the irradiation procedure and group 2 was the control one. The irradiation parameters employed were the following: wavelength 830 nm, one single application of 4 J/cm{sup 2}, punctual in the contact mode and 30 mW power. The control group received the conventional treatment, consisting on topical application of Triancinolon based ointment four times a day. For both groups the agent responsible for the trauma was removed or covered with utility wax whenever removal was impossible. The results were evaluated concerning the wounds size reduction and pain relief. The time of laser irradiation was considered the starting time (time zero) and analysis were done 24 hours, 48 hours and seven days after that. The statistical analysis showed an acceleration in the healing process as well accentuated pain reduction for the irradiated group compared to the control one. These evidences allows us to indicate this protocol of one single application of 4 J/cm{sup 2} as therapy when patients with oral traumatic ulceration can not attend several sessions for a multiple application procedure. (author)

  1. Radiation exposure evaluation of the professional working interventionist procedures in a hemodynamics service; Avaliacao da exposicao a radiacao dos profissionais que executam procedimentos intervencionistas em um servico de hemodinamica

    Energy Technology Data Exchange (ETDEWEB)

    Da Silva, Leonardo Peres

    2004-07-01

    An evaluation of the dose distribution received by all the workers involved on coronary angioplasty, arteriography, coronary angiography and mitral valvuloplasty procedures has been made in this work. For the measurements, LiF:Mg, Ti TLD(TLD 100) was used, located in seven different points on the worker's body: hands, knees, neck, forehead and thorax, inside and outside lead apron.) The measurements have been done for each hemo dynamical procedure, and the TLD calibrated in personal dose equivalent (H{sub p}(d)) operational quantity for 0,07 mm, 3 mm and 10 mm depth. Nurses and auxiliary doctors did not receive expressive dose values, indicating that the adopted radioprotection procedures seem to be appropriate and sufficient for them. However, the same is not true for the doctors direct in charge of the procedure. The results show the importance of the use of thyroid protections in these cases. This work discusses the main factors that cause occupational dose increase. From all interventionist hemo dynamical procedures analyzed, the dose values received by the doctors on coronary angioplasty procedures and coronary angiography were higher than the ones found on arteriography and mitral valvuloplasty. The higher dose values has been found for coronary angiography procedures in X-ray tools, that work with fluoroscopy on continuous mode and have been executed with brachial way, even in the eyes, hands, knees and thyroid, with or without shield. Multiplying these high dose values, measured in one procedure by the mean number of annual procedures made at the studied hospital by each doctor, the individual dose annual limits can be surpassed. Based on these estimations, some optimizations suggestions have been made and one discussion about the need of additional monitoring points is presented. Different algorithms have been used in order to estimate the effective dose, including a new proposal. The obtained results using the actual Radiodiagnostic Brazilian regulation underestimate the dose, in the major part of the measured cases. The proposed algorithm seem sto offer a better estimation for the occupational effective dose for Interventional Radiology. (author)

  2. Study of the heterogeneity effects of lung in the evaluation of absorbed dose in radiotherapy; Estudo dos efeitos da heterogeneidade de pulmao na avaliacao da dose absorvida em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Luciana Tourinho

    2006-02-15

    The main objective of radiotherapy is to deliver the highest possible dose to the tumour, in order to destroy it, reducing as much as possible the doses to healthy tissues adjacent to the target volume. Therefore, it is necessary to do a planning of the treatment. The more complex is the treatment, the more difficult the planning will be, demanding computation sophisticated methods in its execution, in order to consider the heterogeneities present in the human body. Additionally, with the appearing of new radiotherapeutic techniques, that used irradiation fields of small area, for instance, the intensity modulated radiotherapy, the difficulties for the execution of a reliable treatment planning, became still larger. In this work it was studied the influence of the lung heterogeneity in the planning of the curves of percentage depth dose, PDP, obtained with the Eclipse{sup R} planning system for different sizes of irradiation fields, using the correction algorithms for heterogeneities available in the planning system: modified Batho, general Batho and equivalent tissue-air ratio. A thorax phantom, manufactured in acrylic, containing a region made of cork to simulate the lung tissue, was used. The PDP curves generated by the planning system were compared to those obtained by Monte Carlo simulation and with the use of thermoluminescent, TL, dosimetry. It was verified that the algorithms used by the Eclipse{sup R} system for the correction of heterogeneity effects are not able to generate correct results for PDP curves in the case of small fields, occurring differences of up to 100%, when the 1x1 cm{sup 2} treatment field is considered. These differences can cause a considerable subdosage in the lung tissue, reducing the possibility of the patient cure. (author)

  3. Determination of absorbed dose in water: evaluation of dosimetric factors calibration sets used in radiotherapy; Determinacao da dose absorvida na agua: avaliacao dos fatores de calibracao de conjuntos dosimetricos de uso em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Faculdade de Medicina. Departamento de Dermatologia e Radioterapia; Fontana, Julia M.; Santos, Vitor H.P.; Nunes, Isabella P.F.; Okawabata, Francine S., E-mail: marfernandes@fmb.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Instituto de Biociencia

    2014-12-15

    This paper presents a methodology for measuring the dose rate (cGy/min) in a telecobaltotherapy beam, looking emphasize the need for calibration of dosimetric set used and the importance of conducting periodic clinical megavoltage dosimetry of these beams. Two dosimetric set with their respective calibration factors were used. The correction parameters indicated in dosimetry protocols were determined by ionization chambers used. The difference between the value of the dose rate used in the calculation of the service routine and the values obtained in this work with both dosimetric sets proved to be less than 1.5%, and therefore satisfies the maximum recommended tolerance on quality control protocols for this type of therapeutic beam. (author)

  4. Evaluation of the ionizing radiation effects in microbiology, physical and chemical and sensory aspects of ice cream; Avaliacao dos efeitos da radiacao ionizante nos aspectos microbiologicos, fisico-quimicos e sensoriais de sorvetes

    Energy Technology Data Exchange (ETDEWEB)

    Rogovschi, Vladimir Dias

    2015-06-01

    The ice cream is defined as an emulsion of fats and proteins or a mixture of water and sugar, other ingredients may be added provided since they do not affect the product. It is considered a food of high nutritional value, providing lipids, carbohydrates, protein, calcium, phosphorus, and other minerals and vitamins (A, B1, B2, B6, C, D, E and K), and it is considered one of the most important products and higher interest to the dairy industry due to great demand by the consumers. The diseases related to food consumption are considered one of the most significant problems. Several outbreaks related to microbiological contamination of ice cream have been reported in recent decades in Asia, Europe and America. It is believed that the ice cream, as a frozen food, presents no risk to the population health. However, it is considered an excellent environment for the growth of microorganisms due to its composition, pH close to neutrality and long storage period. The aim of this study was to evaluate the microbiological, sensory and physicochemical aspects of ice cream. The ice cream samples were irradiated with gamma rays (60Co) with the doses of LOkGy, 2.0kGy, 3.0kGy and 4.0kGy. The samples intended for the inoculation of Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 11229) and Salmonella abaetetuba (ATCC 35640) have been irradiated with doses of 1.0, 2.0 and 3.0kGy. It can be concluded that the dose of 3.0kGy was adequate to reduce most of the studied microorganisms to undetected levels. The use of gamma radiation affected the texture and the parameters of the colorimetric analyses of the ice cream. The results of the sensorial analyses showed that the better accepted dose was 3.0kGy. (author)

  5. Evaluation of the {sup 14}C-prochloraz residue levels in irradiated mangoes (Mangifera indica) and apples (Malus domestica).; Avaliacao dos niveis de residuos de {sup 14}C-prochloraz em mangas (Mangigera indica) irradiadas e em macas (Malus domestica)

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Maria Aparecida

    1998-07-01

    The Brazilian crops mangoes and apples has expanding in the last years. However, tropical fruits crops are susceptible to infection that harms the crop yield. The control of these diseases is made through fungicides such as prochloraz which possesses protecting eradicating action by controlling anthracnose in mangoes and scabies in apples. Agrochemicals are of great importance in the agriculture considering the of relationship cost/benefit. However they may cause a series of problems in the ecosystem, being the levels of agrochemicals residues in fruits one of these factors. The aim of this work was to evaluate the prochloraz levels in mangoes treated in both stages of pre and post harvest, and in apples treated in the pre harvest. In the treatment of the mangoes, the interaction, fungicide with the gamma radiation with dose of 1,0 kGy, was used to induce prochloraz degradation. Treated post harvest mangoes were stored, at 12 deg C during 21 days. The results showed that the prochloraz did not present reduction in the residual levels of the mangoes after 21 day storage, that is the safe period established by the Brazilian legislation on agrochemicals, in treated mangoes. The refrigerated storage (12 deg C) and the gamma radiation also did not contribute to the degradation of the fungicide in mangoes. In average the concentration of the fungicide prochloraz in the peels (bar X = 1,64 mug/g) was higher than in the mangoes pulp (bar x = 0,06 mug/g), which allows the consumption of this fruit, since the peel is always discarded. The degradation product, formed in peels of mangoes in fruits treated in the pre and post harvest was the metabolite BIS 44596; for mangoes treated in the pre-post harvest the metabolite formed was the BIS 445186. Both metabolites were found in very low levels, confirming that occurs degradation of the fungicide in mangoes. In apples treated with the prochloraz, reduction of 500/0 in the levels. (author)

  6. Radiation effects evaluation for electrons sheaf in packages resistance in a Lasioderma serricorne, Plodia interpunctella and Sitophilus zeamais; Avaliacao dos efeitos da radiacao por feixe de eletrons na resistencia de embalagens a Lasioderma serricorne, Plodia interpunctella e Sitophilus zeamais

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Juliana Nazare

    2011-07-01

    The plagues of stored products consist of a man problem, depreciating products and causing economical damages. Among these curses we have Lasioderma serricorne (F. 1792), Sitophilus zeamais (M. 1855) and Plodia interpunctella (H. 1813) known by infesting stored products as: grains, brans, flours, coffee, tobacco, dried fruits and spices. These curses perforate and penetrate the packages, ovipositing over the substratum. In this context the package plays a fundamental part, preventing the contact and curses' proliferation in the packed product. So, to protect the packed product and to prolong its shelf life, the package should have good mechanical resistance to tension and perforation, good sealing, good barrier properties and should not transfer odors nor strange flavors to the packed product. The ionizing radiation can cause structural changes in polymer packages, these changes are caused by the scission processes and reticulation of the polymers chains. These are concurrent processes and the predominance of one over the other depends on the chemical structure of the polymer, the irradiation conditions and specific factors of the material that will absorb the energy. This work had the objective to evaluate the changes in mechanical properties of package structures used to store granola, cereal bar and pasta, as well as its resistance to perforation by L. serricorne, P. interpunctella and S. zeamais, when submitted to electrons sheaf radiation. In this methodology were used five structures of commercially utilized packages to store granola, cereal bar and pasta composed by (Polypropylene bi-oriented metallic/Polypropylene bi-oriented coextruded - BOPPmet/BOPP 50 {mu}m), (Polypropylene bi-oriented/Polypropylene - BOPP/PP 50 {mu}m), Poli (ethylene terephthalate) metallic/Polypropylene bi-oriented coextruded - PETmet/BOPP 32 {mu}m), Poli (ethylene terephthalate) /Polypropylene - PET/PP1 72 {mu}m), Poli (ethylene terephthalate)/Polypropylene - PET/PP2 32 {mu}m). The structures of packaging were submitted to radiation doses between 0, 10, 20 and 60 kGy, in one electron accelerator of 1,5 M and V, 25 mA and 37,5 kW, dose tax of 11,22 kGy / s, room temperature and air presence . Eight days, Two and Six months after irradiations, mechanical resistance experiment were accomplished to tension and elongating in rupture, sealing resistance and perforation resistance, all based in respective ASTM norms. The perforation experiment by insects were realized in an acclimatized room, where irradiated samples in doses of 0, 10, 20 and 60 kGy were sealed containing 40 g of granola, 40 g of pasta and cereal bar in number of nine by experiment, and equally divided in three plastic screened boxes by studied dose. In each box 20 adults of each insect were added in for 60 days, when the packages were evaluated to verify possible perforations. The differences between the sample results were statistically evaluated by ANOVA (p<0.05). The results showed that concerning the perforation resistance by L. serricorne, P. interpunctella and S. zeamais the polymeric structures evaluated showed low resistance by insects perforation before and after the treatment. BOPPmet/BOPP (50 {mu}m), PETmet/BOPP (32 {mu}m), PET/PP1 (72 {mu}m) and PET/PP2 (32 {mu}m) structures showed significant losses in mechanical properties studied. The BOPP/PP (50 {mu}m) showed the best set of answers in mechanical properties to the radiation treatment with electrons sheaf up to 10 kGy doses. Among the mechanical properties evaluated, sealing was the most affected by ionizing radiation, has shown, in general, increasing losses with radiation dose. (author)

  7. Assessment of radiological problems due to natural radionuclides, in units of exploration and production of petroleum; Avaliacao dos problemas radiologicos devidos aos radionuclideos naturais, em unidades de exploracao e producao de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Matta, Luiz E.S.C.; Godoy, Jose M.O. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil); Reis, Maria C.D.; Pinto, Renato S.M. [PETROBRAS, Macae, RJ (Brazil). Bacia de Campos

    2001-07-01

    This paper describes the study of the occurrence of technologically enhanced natural radioactive material in petroleum offshore platforms of Campos Basin. The material found in drums that came from the platforms and scales from production tubes were analyzed for characterization and determination of its specific activity. There were made measurement of the dose rate in several platforms and radon concentration in onshore and offshore facilities. The results were compared with limits of the Brazilian legislation and international recommendations and actions were proposed to be implemented to assure the workers and environment protection. The results show that with the adequate actions the workers will not receive exposures above the public limits according international recommendations. (author)

  8. Evaluation of failure modes of computerized planning phase of interstitial implants with high dose rate brachytherapy using HFMEA; Avaliacao dos modos de falha do planejamento computadorizado em implantes intersticiais com braquiterapia de alta taxa de dose usando HFMEA

    Energy Technology Data Exchange (ETDEWEB)

    Biazotto, Bruna; Tokarski, Marcio, E-mail: bruna@ceb.unicamp.br [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Centro de Engenharia Biomedica

    2014-08-15

    This paper evaluates the failure modes of the computerized planning step in interstitial implants with high dose rate brachytherapy. The prospective tool of risk management Health Care Failure Mode and Effects Analysis (HFMEA) was used. Twelve subprocesses were identified, and 33 failure modes of which 21 justified new safety actions, and 9 of them were intolerable risks. The method proved itself useful in identifying failure modes, but laborious and subjective in their assessment. The main risks were due to human factors, which require training and commitment of management to their mitigation. (author)

  9. Evaluation of gamma irradiation effects on carotenoids, ascorbic acid and sugar contents of buriti fruit (Mauritia flexuosa L.); Avaliacao dos efeitos da radiacao gama nos teores de carotenoides, acido ascorbico e acucares do fruto Buriti do Brejo (Mauritia flexuosa L.)

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Antonio Luis dos Santos [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Quimica, Quimica Organica e de Produtos Naturais], e-mail: santoslima@ime.eb.br; Lima, Keila dos Santos Cople; Silva, Jaqueline Michele [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Nuclear. Irradiacao de Alimentos], e-mail: keila@ime.eb.br, e-mail: jaquelinefisica@bol.com.br; Coelho, Maysa Joppert [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Secao de Engenharia Nuclear. Engenharia Ambiental], e-mail: maysa@ime.eb.br; Godoy, Ronoel Luiz de Oliveira [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil). Lab. de Cromatografia Liquida, Quimica Organica e de Produtos Naturais], e-mail: ronoel@ctaa.embrapa.br; Pacheco, Sidney [EMBRAPA Agroindustria de Alimentos, Rio de Janeiro, RJ (Brazil). Lab. de Cromatografia Liquida, Ciencia e Tecnologia de Alimentos], e-mail: sidney@ctaa.embrapa.br

    2009-07-01

    Buriti (Mauritia flexuosa L.), a typical fruit from the Northeast and Center-West Amazon of Brazil, is used in many regional dishes. It is considered an excellent source of carotenoids that are A vitamin precursors, showing a majority of beta-carotene. It also presents ascorbic acid and sugar contents. Many studies have indicated that the lack of A vitamin is the main cause of night blindness and xerophthalmia. Also, ascorbic acid deficiency may cause scorbutic disease. The use of food irradiation is growing and represents an economic benefit to agriculture through the reduction of post-harvesting losses while maintaining food nutritional quality. In this study, buriti in natura was treated with gamma irradiation with doses of 0.5 kGy and 1.0 kGy. The objective was to evaluate the irradiation effects on total carotenoids, ascorbic acid and sugars concentrations of buriti. The fruit was evaluated through the total carotenoids analysis, by spectrophotometry, and the carotenoids (alpha and beta-carotene and lutein), ascorbic acid and sugars were determined by high performance liquid chromatography (HPLC). The results showed that buriti is an excellent source of total carotenoids (44600 {mu}g/100 g). The irradiation of buriti with the dose of 0.5 kGy did not significantly change carotenoids and sugars contents. However, there was a reduction of ascorbic acid concentration with an increase of the dose, which may have been caused by irradiation or by intrinsic and extrinsic factors that alter ascorbic acid stability in food, converting ascorbic to dehydroascorbic acid, while keeping the C vitamin active form. (author)

  10. Evaluation of multiple scan average dose (MSAD) levels in computerized tomography in Minas Gerais state, Brazil; Avaliacao dos niveis de dose media em cortes multiplos (MSAD) em tomografia computadorizada no estado de Minas Gerais

    Energy Technology Data Exchange (ETDEWEB)

    Alonso, Thessa C., E-mail: alonso@cdtn.br [Centro de Desenvolvimento de Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Vieira, Leandro de A.; Barbosa, Nayra V.; Oliveira, Jeyselaine R. de; Cesar, Adriana C.Z. [Secretaria de Vigilancia Sanitaria de Minas Gerais, Belo Horizonte, MG (Brazil); Silva, Teogenes A. da [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear. Programa de Ciencias e Tecnicas Nucleares

    2014-07-01

    Computed Tomography (CT) grows every year and is a diagnostic method that has revolutionized radiology with advances in procedures for obtaining image. However, the indiscriminate use of this method generates relatively high doses in patients. The diagnostic reference levels (DRLs) is a practical tool to promote the evaluation of existing protocols. The optimization and the periodic review of the protocols are important to balance the risk of radiation. The present study aims to conduct a survey of levels of MSAD of Minas Gerais following the procedures recommended by current Brazilian law. (author)

  11. Thoracic x-ray in pediatrics: entrance doses evaluation in the skin of the patients; Raios X de torax em pediatria: avaliacao de doses de entrada na pele dos pacientes

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, Eliane; Borges, Jose C. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear; Mota, Helvecio C.; Briquet, Claudia [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil); Rosa, Luis Antonio [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil)

    1998-07-01

    The doses received by children in diagnostic radiology are an important concern on radiological protection due to the potential risk involved, however there is few information about the doses involved in the pediatric exams. This work evaluates the entrance skin doses in children chest examination (ESD), using thermoluminescent dosimeters. The doses presented a range from 0,01 mGy to 0,67 mGy. It was observed that for some age groups the evaluated doses were above the values recommended by European Community. (author)

  12. Evaluation of the effects of gamma radiation in minimally processed vegetables of Brassica oleracea species; Avaliacao dos efeitos da radiacao gama em vegetais da especie Brassica oleracea minimamente processados

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Thaise Cristine Fernandes

    2009-07-01

    The consumption of collard greens (Brassica oleracea cv. acephala) and broccoli (Brassica oleracea L. var. italica) has been inversely associated with morbidity and mortality caused by degenerative diseases. These species are highly consumed in Brazil, which enables its use as minimally processed (MP). The growing worldwide concern with the storage, nutritional quality and microbiological safety of food has led to many studies aimed at microbiological analysis, vitamin and shelf life. To improve the quality of these products, radiation processing can be effective in maintaining the quality of the product, rather compromising their nutritional values and sensory. The aim of this study was to evaluate the effectiveness of gamma radiation from {sup 60}Co at doses of 0, 1.0 and 1.5 kGy on the reduction of microbiota in these plants, and analyze their nutritional and sensory characteristics. The methodology used in this study was microbiological analysis, colorimetric analysis, analysis of phenolic compounds, antioxidant analysis and sensory analysis. The microbiological analysis showed a decrease in the development of populations of aerobic microorganisms, psychotropic and yeast and mold with increasing doses of radiation. The sensory analysis showed no significant difference between different times of cooking analyzed. The analysis of phenolic compounds, significant differences between the samples, suggesting that with increasing dose of irradiation was an increase in the amount of phenolic compounds found in broccoli and collard greens MP. It can be observed that the sample of control collard greens showed high antioxidant activity and for the samples treated by irradiation was a decrease of percentage. In contrast the samples of broccoli show an increase in the rate of scavenging DPPH with increase of the dose of radiation. The colorimetric analysis revealed that for samples of MP collard greens and broccoli foil of no significant differences, but for samples of stems of broccoli significant difference on the yellowing during storage. It is concluded that the processing of collard greens and broccoli butter by gamma radiation may be a viable alternative to the industry, since there was a reduction of the population of microorganisms, without changes in the sensory qualities and with minimum changes in the characteristics that confer antioxidant power. (author)

  13. Study of the effect of ionizing radiation on composites based on PCL/PLLA and coconut fiber; Avaliacao dos efeitos da radiacao ionizante em compositos de PCL/PLLA com fibra de coco

    Energy Technology Data Exchange (ETDEWEB)

    Kodama, Yasko

    2011-07-01

    Plastic solid waste has become a serious problem recently concerning environmental impact. In this scenario, preparation of polymers and composites based on coconut husk fiber would lead to a reduction on the cost of the final product. Additionally, it will reduce the amount of agribusiness waste disposal in the environment. In Brazil, coconut production is around 1.5 billion fruits by year in a cultivated area of 2.7 million hectares, but the coconut husk fiber has not been used much for industrial applications. Moreover, biodegradable polymers have attracted the attention of the most part of population, due to the environmental issues arising from the increasing use of polymeric materials of low degradability discharged as waste residue. Besides, when considering an application in the medical field, it is necessary that the products are sterilized and, ionizing radiation is widely used to sterilize medical and surgical devices. In this work, it was studied blends and composites based on two commercial polymers: poly (e-caprolactone), PCL, and poly (lactic acid), PLLA, and coconut fiber. Those polymers are biodegradable as well as biocompatible, so it is important to know the effect of ionizing radiation in these materials. Samples were irradiated with gamma rays from {sup 60}Co source and electron beam with radiation doses ranging from 10 kGy up to 1 MGy. The non-irradiated and irradiated samples were studied using several analytical techniques and characterization assays that allowed understanding their properties in order to enable their application as precursors for medical and surgical devices. Thermal stability of non irradiated and irradiated composites up to 100 kGy radiation dose is not affected significantly by the coconut fiber incorporation to the polymeric matrix. Acetylation of fibers was not effective in order to induce any interaction between fibers and polymeric matrix, as expected. That was verified by the slight reduction of stress strength observed in the composites specimens. Besides that, this reduction did not affect negatively mechanical properties of blends compared to the composites. Ionizing radiation neither promoted detectable interaction between polymeric matrix and fibers. Cytotoxicity tests indicated that lixiviation products from homopolymers, blend and composites did not release sufficient amount of substances to induce significant cellular death. Thermal processing used to obtain composites and previous acetylation by chemical treatment contributed to the bioburden reduce. Furthermore, reducing initial bioburden it was possible to diminish radiation doses needed to perform sterilization. Enzymatic and soil degradation were not negatively affected by radiation processing. Even though fiber incorporation to the polymer blend slightly reduced degradation process, composites continued degrading through time. Artifacts produced by means of the materials studied here can be radiation processed with doses up to 100 kGy without prejudice of their biodegradability. (author)

  14. In vitro evaluation of ionizing radiation effects in bone tissue by FTIR spectroscopy and dynamic mechanical analysis; Avaliacao in vitro dos efeitos da radiacao ionizante em tecido osseo bovino por espectroscoia ATR-FTIR e analise dinamica-mecanica

    Energy Technology Data Exchange (ETDEWEB)

    Veloso, Marcelo Noronha

    2013-07-01

    Ionizing radiation from gamma radiation sources or X-ray generators is frequently used in Medical Science, such as radiodiagnostic exams, radiotherapy, and sterilization of haloenxerts. Ionizing radiation is capable of breaking polypeptidic chains and causing the release of free radicals by radiolysis.of water. It interacts also with organic material at the molecular level, and it may change its mechanical properties. In the specific case of bone tissue, studies report that ionizing radiation induces changes in collagen molecules and reduces the density of intermolecular crosslinks. The aim of this study was to verify the changes promoted by different doses of ionizing radiation in bone tissue using Fourier Transform Infrared Spectroscopy (FTIR) and dynamic mechanical analysis (DMA). Samples of bovine bone were irradiated using Cobalt-60 with five different doses: 0.01 kGy, 0.1 kGy, 1 kGy, 15 kGy and 75 kGy. To study the effects of ionizing irradiation on the chemical structure of the bone, the sub-bands of amide I, the crystallinity index and relation of organic and inorganic materials, were studied. The mechanical changes were evaluated using the elastic modulus and the damping value. To verify whether the chemical changes and the mechanical characteristics of the bone were correlated, the relation between the analysis made with spectroscopic data and the mechanical analysis data was studied. It was possible to evaluate the effects of different doses of ionizing radiation in bone tissue. With ATR-FTIR spectroscopy, it was possible to observe changes in the organic components and in the hydroxyapatite crystals organization. Changes were also observed in the elastic modulus and in the damping value. High correlation with statistical significance was observed among (amide III + collagen)/{sub v1,v3}, PO{sub 4}{sup 3-} and the delta tangent, and among 1/FHWM and the elastic modulus. (author)

  15. Assessing the safety aspects for use of multilayer pipes in gas distribution of domestic installation; Avaliacao dos aspectos de seguranca para utilizacao de tubos multicamada em instalacoes de distribuicao de gas em residencias

    Energy Technology Data Exchange (ETDEWEB)

    Bratfisch, Carlos do Amaral Coutinho [Bratfisch - Engenharia em Gas, Sao Paulo, SP (Brazil); Emmeti, Sao Paulo, SP (Brazil); Collela, Ricardo [FGS Brasil Industria e Comercio Ltda., Cotia, SP (Brazil)

    2012-07-01

    The gas distribution networks average flow at the Brazilian market is low and the operating pressure is less than 2.0 kgf/cm{sup 2}. These values are lower if compared to other countries and due this, gas distribution companies, major builders and developers have started a movement to find alternatives to reduce their installation costs, and they have identified in other countries the multilayer system. Because of the great interest of the consumer market for this alternative, and since there is no standards in Brazil that could regulate it, a technical committee was established under the ABNT in order to prepare a standard draft meeting the local market particularities as well this technology requirements. Then it was initiated a quest looking for the knowledge of the 'state of the art' of this technology in various locations around the world, especially Europe, Asia and Oceania, which shows that, with few exceptions, the knowledge of this alternative is still on the beginning, and even in countries where this system is a pioneer some doubts exist with respect to their usage limit. The multilayer system materials were already used at hot and cold water networks for more than twelve years, but only after that it was made an adaptation for building installations of gas distribution networks. Due the need to search and establish safety criteria both with respect to the product as its installation shape, did the necessary motivation to perform a more detailed study of this new technology, meeting the needs of this market. The intention is to present to the consumer market a series of comparative data definitions and techniques to identify this as a modern, updated, economic, efficient and safe alternative option for gas distribution networks. (author)

  16. Evaluation of the environmental conditioning factors in the perspective of expansion of ethanol production in Brazil; Avaliacao dos condicionantes ambientais na perspectiva de expansao da producao de etanol no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Conceicao Elaine Cardoso

    2010-03-15

    Various countries have studied the possibility of adding ethanol to gasoline or using pure fuel ethanol as an alternative to petroleum derivatives. Brazil occupies a leading position in this scenario because with its National Alcohol Program (Programa Nacional do Alcool - PROALCOOL), created in 1975, it became the pioneer in setting up a biofuels program. Since then it has accumulated experience and gained mastery of the technology to produce ethanol from sugarcane. Hence there is a strong expectation that the country can become the world's main ethanol exporter. This thesis examines the main environmental impacts associated with the ethanol productive chain, which are relevant conditioning factors for the expansion of this industry in Brazil. The study describes the evolution of PROALCOOL and the overview of current structure of the brazilian sugar-alcohol sector, identifies technologies and environmental management policies, and presents the perspective of expansion of ethanol production. Thus, the study undertakes an extensive review of the literature and examines to what extent the creation and implementation of public and private environmental management policies (legal restrictions and market instruments, respectively) interfere with the expansion of these productive activities. (author)

  17. Gamma radiation (Co{sup 60}) effects on active substances and microbe burden of medicinal plants; Avaliacao dos efeitos da radiacao gama (Co{sup 60}) sobre principios ativos e carga microbiana de plantas medicinais

    Energy Technology Data Exchange (ETDEWEB)

    Dall' Agnol, L. [Herbarium Laboratorio Botanico Ltda, Colombo, PR (Brazil). Dept. de Garantia da Qualidade

    2001-04-01

    In order to evaluate the effects of radioactivity on active vegetal substances, samples of Fennel (Foeniculum vulgare Miller., fructus), Guarana (Paulinia cupana, Kunth, semen), Gingko (gingko biloba, L., folium), and Kawa-Kawa (Piper methysticum G. Forst, rhizoma), were treated with scaling doses (0 to 25 KGy) of gamma radiation (Co{sup 60}). The 'blind test' methodology was used. The active substances from each sample were analysed by qualitative and quantitative methods after radiation. There were no significant differences seen between the control sample (0 KGy) and the irradiated samples. Microbe contamination was significantly reduced, about 10000 CFU/g, with the initial 5 KGy dose. It was concluded that gamma radiation can be used as an alternative procedure to reduce microbiologic contamination in medicinal plants. Before this procedure can be extended to other medicinal plants, more specific analytical methods are recommended to verify possible structural alterations in active vegetal molecules. (author)

  18. Evaluation of acute and chronic toxicity of DSS and LAS surfactants undergoing the irradiation with electron beam; Avaliacao da toxicidade aguda e cronica dos surfactantes DSS e LAS submetidos a irradiacao com feixe de eletrons

    Energy Technology Data Exchange (ETDEWEB)

    Romanelli, Maria Fernanda

    2004-07-01

    Surfactants are synthetic organic compounds widely used in cosmetic, food, textile, dyers and paper production industries and in particular detergents and others cleaning products industries. The world consumption is nearly 8 million tons per year. One of the main environmental issues coming from the use of these compounds is their toxicity that compromises the biological treatment of effluents and the quality of receiving waters. The objective of this work was the application of ionizing radiation by electron beam in the degradation and reduction of acute and chronic toxicities of surfactants sodium dodecylsulfate (SDS), dodecyl p-benzenesulfonate acid (LAS) and sodium dodecyl p-benzenesulfonate (LAS). This treatment technology has been studied as a pre-treatment for effluents containing toxic and non-biodegradable compounds, before the biological treatment. Two acute toxicity assays were employed, one with the micro-crustacean Daphnia similis and the other with the luminescent bacterium Vibrio fischeri along with a chronic toxicity assay with the micro-crustacean Ceriodaphnia dubia (just for SDS and acid LAS) for the non-irradiated and irradiated samples and radiation doses 3.0 kGy, 6.0 kGy, 9.0 kGy and 12.0 kGy. Physical-chemical parameters were evaluated for the following up the degradation of the surfactant molecules. The reductions of acute toxicity varied between 72.49% and 90.98% for SDS, 18.22% and 78.98% for acid LAS and 82.66% and 94.26% for sodium LAS. For the chronic toxicity, the reduction percentages varied between 64.03% and 83.01% for SDS and 47.48% and 64.91% for acid LAS. When one considers the application of the electron beam as a pre-treatment of effluents containing high concentrations of surfactants, the toxicity is an essential parameter allowing the further biological treatment of these effluents. (author)

  19. Evaluation of gains of energy efficiency in illumination with the use of proposed rulemaking labeling for buildings; Avaliacao dos ganhos em eficiencia energetica em iluminacao com o uso da proposta de regulamentacao de etiquetagem para edificios

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Guilherme Augusto Marques; Saidel, Marco Antonio [Universidade de Sao Paulo (USP), SP (Brazil). Escola Politecnica], Emails: guilherme.araujo2@poli.usp.br, saidel@usp.br

    2009-07-01

    This article aims to examine the gains in energy efficiency through the classification levels, assigned to the installation of lighting systems with the use of the proposed regulations for voluntary labeling of the level of energy efficiency in commercial buildings, and public services. Were produced three different simulations: the first, considering a survey of data in an existing building which is hosting an administrative part of the public power, composed of 275 dependences. The second and third simulations deal with the application in a lighting project in the same enterprise, in two different luminaries (composed of optical systems with and without fins, respectively). From these activities that guide the direct application of the methodology for preparation of projects have been established comparisons between the results and made comments on the rates of illuminance, the levels of efficiency and the use of luminaries. (author)

  20. Methodology for evaluation of the stability of electric systems of offshore oil platforms in interconnected operations; Metodologia para a avaliacao dos sistemas eletricos das plataformas de petroleo offshore em operacao interligada

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, Dalmo Junior; Mendes, Pedro Paulo de Carvalho [Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2004-07-01

    The electric system of the platforms usually operates in an isolated way, requesting therefore a redundancy in the generating units so that a can have a reliable and uninterrupted system of their loads. A way to improve the quality in operation in terms of safety, reliability and economy can be the connection of the platforms of petroleum that are close, since it is viable. The objective of this work is to show the methodology for the stability study of the electric system in interlinked operation in way to detail the data of the equipment that are necessary, as: One line Diagram; Transmission lines; Transformers; Power system compensator; Generating; Speed regulators; Voltage regulators; Turbines and other. Another focus of the work is to show some control models and regulation of the electric system to maintain it stable and to show models for the interconnection of two or more platforms. (author)

  1. Effects of the low-intensity red laser radiation on the fluoride uptake in enamel. A clinical trial; Avaliacao dos efeitos da radiacao laser de emissao vermelha em baixa intensidade na incorporacao de fluor no esmalte. Estudo clinico

    Energy Technology Data Exchange (ETDEWEB)

    Nakasone, Regina Keiko

    2004-07-01

    Fluoride has been the most important preventive method on development of the caries. This in vivo study evaluated the effects of low-intensity red laser radiation on the fluoride uptake in enamel. Ten healthy participants were recruited for this study. The two maxillary central incisors of each volunteer to be biopsied were used and divided into 4 groups: group G{sub C} (control, which was untreated; group G{sub F} (fluoride), which received topical acidulated phosphate fluoride (APF) 1,23% treatment for 4 minutes; group G{sub LF} (laser + fluoride), which was irradiated with a low-intensity diode laser ({lambda}= 660 nm and dose= 6 J/cm{sup 2}) with APF application after irradiation and group G{sub FL} (fluoride + laser), which received APF before irradiation using the same parameters as G{sub LF}. The determination of fluoride was performed using a fluoride ion electrode after an acid-etch enamel biopsy. The results show a significant increase of the fluoride uptake in enamel for groups G{sub F}, G{sub LF} and G{sub FL} when compared to control group. Although a percentage increase of 57% was observed for G{sub LF} with respect to G{sub F}, there were no statistical differences among treated groups. These findings suggest that low-intensity laser radiation used before APF could be employed in the clinical practice to prevent dental caries. (author)

  2. Modelo experimental de tumor de Walker Walker’s tumoral experimental model

    Directory of Open Access Journals (Sweden)

    Sandra Pedroso de Moraes

    2000-12-01

    Full Text Available Com o objetivo de padronizar normas técnicas para obtenção de modelo animal com tumor de Walker 256 e de estabelecer o número de células tumorais necessárias para que esse tumor tenha grande porcentagem de pega e longevidade, possibilitando o desenvolvimento de pesquisas em várias áreas da saúde, foi realizado trabalho em duas etapas. Na primeira foram utilizados 120 ratos para treinamento e definição da técnica. Na segunda etapa foram utilizados 84 ratos, sendo estes separados em 7 grupos (G de 12 animais cada. O tumor, na forma ascítica, foi inoculado no tecido celular subcutâneo do dorso dos ratos com os seguintes números de células: GI, 1 x 10(7; GII, 5 x 10(6; GIII, 2,5 x 10(6; GIV, 1 x 10(6; GV, 5 x 10(5; GVI, 3 x 10(5 e GVII, 2 x 10(5. Foram avaliadas a porcentagem de pega e a longevidade nos grupos. Os animais dos GI, GII, GIII e GIV obtiveram 100% de desenvolvimento tumoral, porém baixa longevidade. Os dos GV e GVI obtiveram desenvolvimento tumoral em frequência maior que 90% e longevidade satisfatória. Os do GVII não apresentaram desenvolvimento tumoral. Concluiu-se que todos os procedimentos devem ser exaustivamente treinados e que o número de células tumorais viáveis para inoculação, em tecido celular subcutâneo de ratos, deve estar na faixa entre 5 x 10(5 e 3 x 10(5.The aim of this work was standardize technical norms to obtain a model of Walker 256 tumor in animals and get the tumorous cells number needed to increase the tumorous join percentage and longevity, it makes possible the research development in several health areas. The work was realized in two stages. In first were used 120 rats to crew’s training and technicals definitions. In second stage were used 84 rats, these separated in 7 groups (G with 12 animals each one. The tumor, in ascitic form was inoculated on subcutaneous cellular tissue on dorsal of rats with the follow number of cells : GI, 1 x 10(7; GII, 5 x 10(6; GIII, 2,5 x 10(6; GIV, 1

  3. Avaliacao da espessura medio-intimal em pacientes com doenca renal cronica nao dialitica: estudo prospectivo de 24 meses

    Directory of Open Access Journals (Sweden)

    Andrea Gaspar Marcos

    2014-03-01

    Full Text Available Introdução: O aumento da espessura média-intimal (EMI avaliada por ultrassom é um preditor de risco cardiovascular na população geral. Porém, em pacientes com doença renal crônica nos estágios iniciais, essa associação ainda não está bem estabelecida. Objetivo: Avaliar a associação EMI com a ocorrência de eventos cardiovasculares e mortalidade em pacientes nos estágios iniciais da doença renal crônica. Métodos: A análise post hoc de uma coorte de pacientes nos estágios 2-4 da DRC. Foram avaliados dados laboratoriais, ultrassom da artéria carótida e tomografia coronariana no início do estudo e a ocorrência de óbito, em seguimento por 24 meses. Resultados: Um total de 117 pacientes (57 ± 11 anos, 61% sexo masculino foram avaliados. A taxa de filtração glomerular foi 36 ± 17 mL/min, 96% dos pacientes eram hipertensos, 23% diabéticos e 27% obesos. Calcificação arterial coronariana esteve presente em 48% dos pacientes, sendo mais prevalente em pacientes nos estágios mais avançados da DRC (p = 0,02. EMI foi 0,6 mm (0,4-0,7 mm. Comparado aos pacientes com EMI < 0,6mm, aqueles com EMI ≥ 0,6 mm eram mais velhos (p = 0,001, apresentavam maior prevalência do sexo masculino (p = 0,001, menor taxa de filtração glomerular (p = 0,01 e maior proporção de pacientes com calcificação (p = 0,001. Não foi observada relação entre a espessura média-intimal e a ocorrência de evento cardiovascular e óbito. Conclusão: A espessura médio-intimal em pacientes DRC se associou à calcificação coronariana, mas não à ocorrência de eventos cardiovasculares e óbito, em um seguimento de 24 meses.

  4. PERFIL E EXPECTATIVAS DOS ALUNOS CONCLUINTES DOS CURSOS TECNICOS INTEGRADOS DO IFRN, CAMPUS APODI

    Directory of Open Access Journals (Sweden)

    Saara Ramila Gurgel de Oliveira

    2014-11-01

    Full Text Available Este trabalho teve por finalidade caracterizar o perfil e as expectativas dos alunos dos terceiros e quartos anos dos cursos técnicos integrado de Zootecnia e Biocombustíveis do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte – Campus Apodi. A pesquisa foi realizada com 138 alunos, através da aplicação de questionários com perguntas abertas e fechadas. A análise dos dados foi realizada de maneira descritiva e os mesmos apresentados em percentuais. Os principais resultados mostraram que as mulheres são maioria (60,9% e que a idade média foi de 17,4 anos. 99,3% dos alunos afirmaram querer cursar uma faculdade e a Universidade Federal do Rio Grande do Norte foi a instituição mais citada. Os cursos mais citados pelos discentes foram: Medicina, Ciência e tecnologia, Engenharia química, Engenharia civil, Direito e Medicina veterinária. Quanto a prática profissional, 89,9% dos alunos a realizam na forma de projetos de pesquisa ou extensão e 10,1% na forma de estágios. Mais de 97% dos estudantes estão satisfeitos com as disciplinas, porém 64,5% não estão satisfeitos com a quantidade de aulas práticas dos cursos. Quanto ao mercado de trabalho, 58,8% acreditam que há boas oportunidades. Dessa forma, conclui-se que são necessárias medidas para qualificar o ensino dos alunos, todavia, as mesmas dependem de uma gestão democrática que analise a opinião de toda a comunidade escolar.

  5. A Teoria dos Conjuntos de Cantor

    Directory of Open Access Journals (Sweden)

    Antônio Acra Freiria

    1992-07-01

    Full Text Available No final dos anos 50 e começo doe anos 60, houve uma reformulação significativa da Matemática no Brasil. Sob a bandeira do modernismo, seus defensores buscaram inovações no ensino da Matemática. Dessa forma, os reformistas se concentraram essencialmente na linguagem abusiva e no formalismo da Teoria dos Conjuntos, o que trouxe mais danos do que benefícios do ensino da Matemática de 1º e 2ºgraus. A linguagem formal da Teoria dos Conjuntos é porém sua parte menos importante. A teoria criada por Cantor tão logo revelou-se como o fundamento de toda a Matemática, possibilitando o desenvolvimento de novas disciplinas, como a Topologia, a Algebra Abstrata, a Teoria da Medida e Integração, a Teoria da Probabilidade e a Análise Funcional. O objetivo deste trabalho é um relato sucinto de como surgiu essa teoria, apresentando o "Conjunto de Cantor" como um dos mais ricos exemplos de "Conjunto perfeito" encontrados na literatura matemática.

  6. Lung Carcinoid Tumor: Surgery

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » Surgery to treat lung carcinoid tumors Share this Page Close Push escape to close share window. Print ...

  7. Testicular germinal tumors

    International Nuclear Information System (INIS)

    This work is about diagnosis, treatment and monitoring of testicular germinal tumors. The presumed diagnosis is based in the anamnesis, clinical examination, testicular ultrasound and tumor markers. The definitive diagnosis is obtained through the inguinal radical orchidectomy

  8. Pediatric Brain Tumor Foundation

    Science.gov (United States)

    ... you insights into your child's treatment. LEARN MORE Brain tumors and their treatment can be deadly so ... Michigan event celebrates 25 years Read more >> Pediatric Brain Tumor Foundation 302 Ridgefield Court, Asheville, NC 28806 ...

  9. Benign Liver Tumors

    Science.gov (United States)

    ... Handouts Education Resources Support Services Helpful Links For Liver Health Information Call 1-800-GO-LIVER (1- ... Liver > Liver Disease Information > Benign Liver Tumors Benign Liver Tumors Explore this section to learn more about ...

  10. Metaphyseal giant cell tumor

    International Nuclear Information System (INIS)

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed. (Author)

  11. Metaphyseal giant cell tumor

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, L.F.; Hemais, P.M.P.G.; Aymore, I.L.; Carmo, M.C.R. do; Cunha, M.E.P.R. da; Resende, C.M.C.

    Three cases of metaphyseal giant cell tumor are presented. A review of the literature is done, demostrating the lesion is rare and that there are few articles about it. Age incidence and characteristics of the tumor are discussed.

  12. Solubilidade e disponibilidade dos micronutrientes em fertilizantes

    Directory of Open Access Journals (Sweden)

    F. Vale

    1999-06-01

    Full Text Available A legislação brasileira exige que os micronutrientes nos fertilizantes sejam garantidos pelo teor total presente. Isto abre um precedente para a utilização de produtos não considerados como fontes de micronutrientes na fabricação dos fertilizantes. Todavia, a eficiência agronômica desses produtos é ainda duvidosa. Objetivou-se realizar um trabalho para caracterizar a solubilidade e a disponibilidade dos micronutrientes em trinta fertilizantes comerciais, por meio do uso de cinco extratores químicos: a água e soluções de ácido cítrico a 2%, de citrato neutro de amônio na diluição 1 + 9, de DTPA 0,005 mol L-1 e de EDTA 0,005 mol L-1. Os resultados mostraram a baixa solubilidade dos micronutrientes metálicos (cobre, ferro, manganês e zinco dos fertilizantes tipo "fritas". O ácido cítrico a 2% mostrou-se promissor na caracterização da disponibilidade de cobre, manganês e zinco para as plantas. Para o ferro não houve uma definição entre os extratores estudados. O boro teve boa solubilidade, tanto nos fertilizantes solúveis, como nos insolúveis em água, e a garantia pelo teor total mostrou-se bom indicativo da disponibilidade do elemento. Para o molibdênio a solubilidade foi maior para os fertilizantes com baixo teor do elemento. A garantia dos micronutrientes catiônicos pelo teor total, conforme exige a legislação, não indicou a sua real disponibilidade nos fertilizantes comerciais, mostrando a necessidade de uma definição de extratores para esse fim.

  13. Nonislet Cell Tumor Hypoglycemia

    OpenAIRE

    Johnson Thomas; Salini C. Kumar

    2013-01-01

    Nonislet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia. It is characterized by increased glucose utilization by tissues mediated by a tumor resulting in hypoglycemia. NICTH is usually seen in large mesenchymal tumors including tumors involving the GI tract. Here we will discuss a case, its pathophysiology, and recent advances in the management of NICTH. Our patient was diagnosed with poorly differentiated squamous cell carcinoma of esophagus. He continued to be hypoglycemic ...

  14. Tumores do plexo coróideo

    OpenAIRE

    PIANETTI GERALDO; FONSECA LUIZ FERNANDO

    1998-01-01

    É feita análise estatística, semiológica, terapêutica e da evolução de 15 crianças portadoras de tumor do plexo coróideo, tratadas cirurgicamente no Serviço de Neuropediatria dos Hospitais das Clínicas (UFMG) e São Francisco de Assis, num período de 15 anos (1981 a 1996). A idade variou de quatro meses a 16 anos, com média de três anos e seis meses, dez tinham menos de dois anos; nove eram do sexo feminino; 14 tinham sinais de hipertensão intracraniana; em todas elas a presença do tumor foi c...

  15. Soft tissue mixed tumor

    OpenAIRE

    Eiichi Hiraishi; Hiroshi Sakihara; Michiro Susa; Takayuki Honma; Hiroshi Shimosawa

    2009-01-01

    Mixed tumors are relatively common in the skin and salivary glands, but extremely rare in soft tissues, often resulting in diagnostic problems. The occurrence of these tumors in the hand is especially limited. In this article we report the clinical, radiological, and histological features of a mixed tumor of the hypothenar region of the right hand.

  16. Brain Tumor Symptoms

    Science.gov (United States)

    ... experience symptoms associated with their tumor(s) and/or treatment(s). People with brain tumors often suffer from: Headaches Seizures Sensory (touch) and motor (movement control) loss Deep venous thrombosis (DVT, or blood clot) Hearing loss Vision loss ...

  17. Malignant tumors of childhood

    International Nuclear Information System (INIS)

    This book contains 34 papers about malignant tumors. some of the titles are: Invasive Cogenital Mesoblastic Nephroma, Leukemia Update, Unusual Perinatal Neoplasms, Lymphoma Update, Gonadal Germ Cell Tumors in Children, Nutritional Status and Cancer of Childhood, and Chemotherapy of Brain tumors in Children

  18. Brain and Spinal Tumors

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Brain and Spinal Tumors Information Page Synonym(s): Spinal Cord ... en Español Additional resources from MedlinePlus What are Brain and Spinal Tumors? Tumors of the brain and ...

  19. Tumor penetrating peptides

    Directory of Open Access Journals (Sweden)

    ErkkiRuoslahti

    2013-08-01

    Full Text Available Tumor-homing peptides can be used to deliver drugs into tumors. Phage library screening in live mice has recently identified homing peptides that specifically recognize the endothelium of tumor vessels, extravasate, and penetrate deep into the extravascular tumor tissue. The prototypic peptide of this class, iRGD (CRGDKGPDC, contains the integrin-binding RGD motif. RGD mediates tumor homing through binding to αv integrins, which are selectively expressed on various cells in tumors, including tumor endothelial cells. The tumor-penetrating properties of iRGD are mediated by a second sequence motif, R/KXXR/K. This C-end Rule (or CendR motif is active only when the second basic residue is exposed at the C-terminus of the peptide. Proteolytic processing of iRGD in tumors activates the cryptic CendR motif, which then binds to neuropilin-1 activating an endocytic bulk transport pathway through tumor tissue. Phage screening has also yielded tumor-penetrating peptides that function like iRGD in activating the CendR pathway, but bind to a different primary receptor. Moreover, novel tumor-homing peptides can be constructed from tumor-homing motifs, CendR elements and protease cleavage sites. Pathologies other than tumors can be targeted with tissue-penetrating peptides, and the primary receptor can also be a vascular “zip code” of a normal tissue. The CendR technology provides a solution to a major problem in tumor therapy, poor penetration of drugs into tumors. The tumor-penetrating peptides are capable of taking a payload deep into tumor tissue in mice, and they also penetrate into human tumors ex vivo. Targeting with these peptides specifically increases the accumulation in tumors of a variety of drugs and contrast agents, such as doxorubicin, antibodies and nanoparticle-based compounds. Remarkably the drug to be targeted does not have to be coupled to the peptide; the bulk transport system activated by the peptide sweeps along any compound that is

  20. Tumors in invertebrates

    Directory of Open Access Journals (Sweden)

    F Tascedda

    2014-06-01

    Full Text Available Tumors are ectopic masses of tissue formed by due to an abnormal cell proliferation. In this review tumors of several invertebrate species are examined. The description of tumors in invertebrates may be a difficult task, because the pathologists are usually inexperienced with invertebrate tissues, and the experts in invertebrate biology are not familiar with the description of tumors. As a consequence, the terminology used in defining the tumor type is related to that used in mammalian pathology, which can create misunderstandings in some occasions.

  1. Epilepsy and Brain Tumors

    Institute of Scientific and Technical Information of China (English)

    Zhi-yi Sha

    2009-01-01

    @@ Epidemiology It is estimated 61,414 new cases of primary brain tumors are expected to be diagnosed in 2009 in the U.S. The incidence statistic of 61,414 persons diagnosed per year includes both malignant (22,738) and non-malignant (38,677) brain tumors. (Data from American Brain Tumor Association). During the years 2004-2005, approximately 359,000 people in the United States were living with the diagnosis of a primary brain or central nervous system tumor. Specifically, more than 81,000 persons were living with a malignant tumor, more than 267,000 persons with a benign tumor. For every 100,000 people in the United States, approximately 131 are living following the diagnosis of a brain tumor. This represents a prevalence rate of 130.8 per 100,000 person years[1].

  2. Estudo do perfil dos turistas luxemburgueses

    OpenAIRE

    Leal, Kelen

    2012-01-01

    Perante a atual evolução dos mercados turísticos e a mudança no comportamento do turista, torna-se fundamental conhecer profundamente as necessidades, as motivações e as preferências dos consumidores-turistas, de modo a obter uma eficaz capacidade de resposta às necessidades e preferências da procura. Com o aumento da competitividade entre os destinos turísticos surgem mais desafios às empresas, não só as que estão ligadas ao setor como as que estão relacionadas ao próprio destino, o que l...

  3. impacto na cavidade oral dos pacientes

    OpenAIRE

    Barros, Gisela Cristina Moreira

    2010-01-01

    A Síndrome de Sjögren (SS) é uma patologia de origem autoimune, que se caracteriza imunológicamente, por um infiltrado linfocitário nas glândulas salivares e lacrimais dos indivíduos afectados. A SS pode-se dividir em Síndrome de Sjögren Primário e Síndrome de Sjögren Secundário. Os principais sintomas são a secura da boca, dos olhos e o cansaço extremo. A infiltração plasmática e linfocitária nas glândulas exócrinas e, consequentemente, a produção de auto-anticorpos, leva a...

  4. Metabolismo dos lípidos

    OpenAIRE

    Ibarguren Arizeta, Izaskun

    2011-01-01

    Esta unidade didáctica, Metabolismo dos lípidos, englóbase dentro da materia Bioquímica que se imparte na titulación de Grao en Veterinaria. No plano de estudos, a materia está integrada no módulo de formación básica común, impártese no primeiro semestre do primeiro curso, e ten una carga lectiva de 6 créditos ECTS. Así pois, os destinatarios son alumnos de primeiro curso de veterinaria. A Bioquímica estuda as bases moleculares dos seres vivos, isto é, como son, como interaccionan e a ...

  5. Defesa dos direitos humanos: sistemas regionais

    Directory of Open Access Journals (Sweden)

    Hélio Bicudo

    2003-04-01

    Full Text Available O texto discorre sobre a institucionalização dos sistemas de promoção dos Direitos Humanos, ao longo do século XX. Tomando a Declaração Universal dos Direitos do Homem, de 1948, como base e ponto de partida, o articulista aborda as três principais vertentes dos sistemas de promoção desses direitos: a européia, a americana e a africana. A evolução de cada uma delas descrita analógica e epistemologicamente, de forma a salientar singularidades sem perder de vista as influências recíprocas ou mesmo as determinantes próprias do contexto espaço-social. Para finalizar, o articulista destaca a importância do Tribunal Penal Internacional no estabelecimento de uma justiça ecumênica. Concomitantemente, alerta para o perigo contido na ameaça de os EUA não o ratificarem.The text underlines the institutional character acquired by the main systems to promote Human Rights in the twentieth century. Taking the Universal Human Rigths Declaration, of 1948, as the basis for analysis, the author brings up three different approaches to promote these rights: the European, the American and the African. The evolution of each of them is described using its procedure as a basic reference. Besides, an analogical analysis, brings to the fore singularities, without ignoring reciprocal influences dictated by particular contexts, though. The author stresses the importance of the International Penal Court, as a means to establish ecumenical justice. At the same time, he reminds the reader of the risks implicit in the possible non-ratification of the IPC by United States.

  6. DOS: the discrete-ordinates system

    International Nuclear Information System (INIS)

    The Discrete Ordinates System determines the flux of neutrons or photons due either to fixed sources specified by the user or to sources generated by particle interaction with the problem materials. It also determines numerous secondary results which depend upon flux. Criticality searches can be performed. Numerous input, output, and file manipulation facilities are provided. The DOS driver program reads the problem specification from an input file and calls various program modules into execution as specified by the input file

  7. Dos nuevos puentes ligeros, en Alemania

    Directory of Open Access Journals (Sweden)

    Bay, Hermann

    1961-03-01

    Full Text Available Las dos obras, objeto de ligera descripción en este trabajo, dan patentes muestras de las direcciones generales en el orden constructivo hacia la belleza, esbeltez y función específica, objeto éste, que ha de cubrir las exigencias de la explotación pública, en este caso, de la obra.

  8. Osteomalacia oncogénica: Presentación de dos casos

    OpenAIRE

    2015-01-01

    La osteomalacia oncogénica es una enfermedad rara. Existen descriptos alrededor de 337 casos. Es ocasionada por un tumor productor del factor de crecimiento fibroblástico 23 (FGF-23), hormona que disminuye la reabsorción tubular de fosfatos y altera la hidroxilación renal de la vitamina D, con hipofosfatemia, hiperfosfaturia y niveles bajos de calcitriol. Se presentan dos pacientes de 44 y 70 años, que consultaron por dolores óseos generalizados de aproximadamente un año de evolución en los q...

  9. Dos museos en México

    Directory of Open Access Journals (Sweden)

    Ramírez Vázquez, P.

    1967-03-01

    Full Text Available 1. Modem Art Museum, at México City This consists of two buildings, the Art Museum and the Art Gallery. The first has two floor levels and contains six circular halls for exhibitions, linked together by common utilities (public, administrative and maintenance offices, and by a large vestibule, which is also round and extends up to the second floor. The art gallery also has two floors, and has a circular exhibition hall on the second floor, and various services in the lower floor. A central vestibule connects both floors and the exterior. The formal expressivity of both blocks and the surrounding site are highly impressive because of their harmony and plasticity. 2. Ciudad Juárez Museum This museum has a central block, of circular base, which is occupied with four exhibition halls, and a second block, concentric with the first one, which also contains a number of exhibition rooms. The fortunate arrangement of volumes, their shape and texture, and their emplacement in the centre of a lake, make this an especially attractive building.1. Museo de arte Moderno, en la Ciudad de México El conjunto construido consta de dos edificios: el Museo de Arte y la Galería de Arte. El primero se ha resuelto en dos plantas, y alberga: seis salas circulares para exposiciones, unidas entre sí por los servicios comunes (públicos, administrativos y de entretenimiento, y un gran vestíbulo, también circular, de doble altura. El segundo se ha organizado asimismo en dos niveles, y consta de una sala circular para exposiciones en planta alta y servicios en planta baja, ligando ambas zonas por medio de un vestíbulo central, que los comunica al exterior. La expresividad formal de los dos cuerpos construidos y el paraje elegido para emplazarlos constituyen un acierto plástico y de ambientación. 2. Museo en Ciudad Juárez Comprende este edificio: un cuerpo central, de planta circular, que alberga: cuatro salas de exposiciones; y otro, concéntrico con el anterior

  10. Tumor sólido pseudopapilar do pâncreas Solid pseudopapillary tumor of the pancreas

    Directory of Open Access Journals (Sweden)

    Ivan Maluf Junior

    2010-11-01

    Full Text Available O tumor sólido pseudopapilar de pâncreas é uma neoplasia rara, que acomete usualmente mulheres jovens na segunda ou terceira década de vida. Foi descrito pela primeira vez em 1959. É considerada uma doença com baixo potencial de malignidade e é encontrado na maioria dos casos em adolescentes do sexo feminino, sugerindo a associação de fatores hormonais em sua patogênese. Metástases são raras e a ressecção completa do tumor é geralmente curativa. O caso descrito é sobre uma paciente de 13 anos. Os aspectos clínicos envolvidos neste caso foram atípicos pelo fato do surgimento dos sintomas associados a trauma direto com aumento de volume abdominal. O tumor pode acometer qualquer área do pâncreas, porém, na maioria das séries, acomete, preferencialmente, o corpo e a cauda pancreática. A ressecção do tumor, quando possível, é curativa na maioria dos casos, porém recidivas locais podem ocorrer. A taxa de sobrevida mesmo após metástase hepática é alta pela natureza benigna do tumor. Conclusão: O tratamento cirúrgico por meio de ressecção tumoral sem esvaziamento ganglionar ou ressecção de órgãos adjacentes é recomendável pela literatura internacional proporcionando excelente prognóstico para estes pacientes.Introduction: Solid pseudopapillary tumors of the pancreas (SPTs are uncommon tumors usually affecting young women in their twenties and thirties, suggesting hormonal factors to be involved in their pathogenesis. It was first described by Frantz in 1959. The vast majority of SPTs are indolent neoplasms. Metastases are rare and resection of the tumor when possible is curative in most cases. Case report: We report a case of a 13-year-old white girl. The clinical aspects of this case were atypical due to the appearance of symptoms associated with direct trauma and increase of the abdominal volume. Discussion: The body and tail of the pancreas are more frequently affected. The survival rate even after liver

  11. Bone tumors: Nursing care

    International Nuclear Information System (INIS)

    Bone tumors represent approximately 5% of childhood malignancies. osteosarcoma is the primary malignant bone tumor, accounting for 60% of cancer with peak incidence in the 2nd decade of life. Ewing's sarcoma is the second most common bone cancer with peak at a slightly younger age. This presentation discusses similarities and differences in the diagnosis and treatment of these two malignancies. Diagnostic procedures include plain radiographs, CT and MRI of the primary site, plain x-ray and CT of the chest, bone scan, and biopsy of the primary tumor. For patients diagnosed with Ewing's sarcoma, a bone marrow aspirate and biopsy will also be required. Our current approach to the treatment of bone tumors includes preoperative combination chemotherapy and en bloc surgical removal of the tumor followed by postoperative chemotherapy. In the case of Ewing's sarcoma, radiation therapy may be employed in addition to surgery, if margins are questionable of instead of surgery, if the tumor is not resectable

  12. Pulmonary neuroendocrine (carcinoid) tumors

    DEFF Research Database (Denmark)

    Caplin, M E; Baudin, E; Ferolla, P;

    2015-01-01

    relevant literature was carried out, followed by expert review. RESULTS: PCs are well-differentiated neuroendocrine tumors and include low- and intermediate-grade malignant tumors, i.e. typical (TC) and atypical carcinoid (AC), respectively. Contrast CT scan is the diagnostic gold standard for PCs, but...... used, however, temozolomide has shown most clinical benefit. CONCLUSIONS: PCs are complex tumors which require a multidisciplinary approach and long-term follow-up....

  13. Percutaneous Bone Tumor Management

    OpenAIRE

    Gangi, Afshin; Buy, Xavier

    2010-01-01

    Interventional radiology plays a major role in the management of bone tumors. Many different percutaneous techniques are available. Some aim to treat pain and consolidate a pathological bone (cementoplasty); others aim to ablate tumor or reduce its volume (sclerotherapy, thermal ablation). In this article, image-guided techniques of primary and secondary bone tumors with vertebroplasty, ethanol injection, radiofrequency ablation, laser photocoagulation, cryoablation, and radiofrequency ioniza...

  14. Adenomatoid Tumor of Testis

    OpenAIRE

    Amin, Waqas; Parwani, Anil V

    2009-01-01

    Adenomatoid tumors are responsible for 30% of all paratesticular masses. These are usually asymptomatic, slow growing masses. They are benign tumors comprising of cords and tubules of cuboidal to columnar cells with vacuolated cytoplasm and fibrous stroma. They are considered to be of mesothelial origin supported by histochemical studies and genetic analysis of Wilms tumor 1 gene expression. Excision biopsy is both diagnostic and therapeutic procedure. The main clinical consideration is accur...

  15. Olfactory ensheathing cell tumor

    Directory of Open Access Journals (Sweden)

    Ippili Kaushal

    2009-01-01

    Full Text Available Olfactory ensheathing cells (OECs are found in the olfactory bulb and olfactory nasal mucosa. They resemble Schwann cells on light and electron microscopy, however, immunohistochemical staining can distinguish between the two. There are less than 30 cases of olfactory groove schwannomas reported in the literature while there is only one reported case of OEC tumor. We report an OEC tumor in a 42-year-old male and discuss the pathology and origin of this rare tumor.

  16. Brain tumor - children

    Science.gov (United States)

    Glioblastoma multiforme - children; Ependymoma - children; Glioma - children; Astrocytoma - children; Medulloblastoma - children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children)

  17. As religiões dos brasileiros

    Directory of Open Access Journals (Sweden)

    Pierre Sanchis

    2009-05-01

    Full Text Available Há dois movimentos simultâneos no campo religioso brasileiro: um primeiro de distinção, multiplicação e rupturas; um segundo de relativa homogeneização.  No campo cristão, o fenômeno mais visível é o da entrada maciça dos pentecostais, não só na arena religiosa em geral, mas nos seus pontos de alta visibilidade, especialmente populares. O significado da preferência dos pobres e do aparente trânsito do catolicismo ao pentecostalismo tende a representar o trânsito entre duas culturas: a tradicional católica afro-brasileira, e a cultura moderna de escolha individual.  A Nova Era, por exemplo, representa ao mesmo tempo a contudente negação de uma modernidade individualista, racional e dessacralizadora, a tentativa de recapitular, no que tem de global, espiritual, carnal e cósmico, o caminhar do homem para uma completude nunca atingida, porque nunca concluída.  Assim, o meio religioso brasileiro, sobretudo popular, mas não exclusivamente, vive num certo clima espiritualista que parece compartilhado por várias mentalidades no Brasil. Pode-se então levantar a seguinte questão: como escapar, neste nosso olhar sobre as religiões dos brasileiros, de uma visão tão linearmente evolucionista, positivista na sua concepção, repressiva na sua política?

  18. O mundo dos bens, vinte anos depois

    Directory of Open Access Journals (Sweden)

    Mary Douglas

    2007-12-01

    Full Text Available A partir do anúncio da reedição de seu livro O Mundo dos Bens, publicado originalmente em 1979, a autora faz uma reflexão do contexto intelectual em que sua obra foi fundamentada. Ela discute as bases da importância do estudo do consumo para a economia e para a antropologia, salientando que isso pode contribuir para alcançar o projeto de "totalidade" dos fenômenos sociais, na perspectiva de Marcel Mauss - autor que teve grande influência para O Mundo dos Bens. O artigo ainda mostra trabalhos e debates clássicos sobre o tema das trocas que contribuíram para as reflexões desenvolvidas no livro. É retomado o argumento de que a pobreza deve ser entendida como um processo de exclusão de informação e, nesse sentido, a autora expõe porque o estudo sobre o consumo é de grande valia para a antropologia.Taking into account the announcement of the re-edition of her book The World of Goods, originally published in 1979, the author develops a reflection on the intellectual context in which her work was created. She discusses the bases of the importance of Consumption Studies for Economics and Anthropology, suggesting that they help to attain the project of "totality" in the study of social phenomena, following the notion of Marcel Mauss - an author who exerted a great influence in the The World of Goods. The article also analyses classical works and discussions about exchanges that contributed to the reflections developed in the book. She resumes her central point, that is, that poverty must be understood as a process concerning the exclusion of information. In this sense, she presents the reasons the study on consumption is of great value for Anthropology.

  19. Silvina Ocampo: la vejez en dos tiempos

    OpenAIRE

    Mancini, Adriana

    2004-01-01

    El presente artículo aborda la representación de la vejez y la muerte en dos momentos de producción de la obra de Silvina Ocampo. La configuración y el comportamiento de ciertos personajes de una serie de cuentos de Viaje olvidado (1937), La furia y otros cuentos (1959) y Los días de la noche (1970) manifiestan aspectos constitutivos de la vejez; por su parte, los últimos textos de Cornelia frente al espejo (1988) presentan la conflictiva relación entre el viejo, su vejez y la muerte.

  20. Por uma carta dos bens fundamentais

    Directory of Open Access Journals (Sweden)

    Luigi Ferrajoli

    2010-07-01

    Full Text Available Este artigo questiona a possibilidade de a estipulação dos direitos fundamentais, e suas obrigações e proibições correspondentes, ser suficiente para garantir adequadamente as necessidades e os interesses vitais, em especial aqueles de interesse coletivo. São bens fundamentais aqueles cujo acesso é garantido a todos e a cada um, visto que são objetos dos direitos fundamentais subtraídos à lógica do mercado. A garantia de novos bens como bens fundamentais exige uma decisão política civilizatória de submeter ao direito as relações de mercado. Assim, às cartas e convenções internacionais e constitucionais de direitos fundamentais deveriam ser acrescentadas Cartas Constitucionais e Cartas Internacionais de bens fundamentais. Daí a necessidade de uma nova dimensão do constitucionalismo garantista: a longo prazo, além de global, para além da lógica individualista dos direitos e da miopia, e do estreito localismo da política das democracias nacionais.AbstractThis article addresses the question of whether the stipulation of fundamental rights and obligations and prohibitions related to them is sufficient to properly ensure the needs and vital interests, especially those from collective interest. Fundamental goods are those whose access is guaranteed to each and every one since they are the object of fundamental rights, excluded from the logic of the market. The warranty for new goods and basic goods in the bottom of civilization requires a political decision to submit the right market relations. Thus, to the international charters and conventions and fundamental constitutional rights should be added Charters and international charter of basic goods. Hence the need for a new dimension of the constitutionally guaranteed: a constitutionally guaranteed in the long term, and global, apart from the individualistic logic of rights and shortsightedness and narrow localism policy of national democracies.

  1. Lista dos Anelídeos (Annelida)

    OpenAIRE

    Paulo A V Borges

    2010-01-01

    A diversidade das minhocas (Annelida) é aqui compilada, em adição aos grupos de animais terrestres listados em detalhe noutros capítulos deste livro (Platyhelminthes, Nematoda, Mollusca, Arthropoda, Chordata). Com base na recente lista de espécies animais terrestres da Europa, projecto “Fauna Europaea” (http:// www.faunaeur.org), listam-se 21 espécies de anelí deos terrestres. É apresentada a distribuição das espécies ou subespécies nas nove ilhas dos Açores, usando-se a seguinte simbologia: ...

  2. Do capitalismo à ética dos negócios: para uma abordagem dos valores

    OpenAIRE

    Nogueira, António de Vasconcelos

    1997-01-01

    Este artigo tem por objectivo a compreensão interpretativa do capitalismo como sistema e dos seus sentidos doutrinais. No plano metodológico, a argumentação radica na consulta de fontes bibliográficas, conduzida para uma reflexão axiológica que privilegiou momentos de análise conceptual numa perspectiva diabética e hermenêutica, a par da contextualização dos assuntos, da sua actualizada e pertinência, com aportações ao caso português. Procurou-se ainda validar o essencial da tese de Weber, ev...

  3. Influência dos factores de caracterização dos portos no desempenho

    OpenAIRE

    Caldeirinha, Vítor Manuel dos Ramos

    2010-01-01

    O presente trabalho de investigação tem como objectivo determinar qual o impacto dos factores de caracterização dos portos no seu desempenho. Consistiu em explicar o desempenho do porto com base nos diversos factores o que caracterizam e a sua importância relativa. Foram utilizadas as metodologias DEA - data envelopment analysis-, análise factorial, regressão linear simples, “path analysis” e SEM – structural equation model. A amostra de 43 portos europeus foi recolhida através de inquéritos ...

  4. Sobre a peleja dos sujeitos da reforma, ou da reforma dos sujeitos em peleja

    Directory of Open Access Journals (Sweden)

    Gastão Wagner de Sousa Campos

    1992-01-01

    Full Text Available O presente trabalho analisa os principais impasses da reforma sanitária brasileira, bem como avalia a atuação do movimento de saúde a nível das instituições. Aplicando à saúde conceitos de Gramsci, F. Guattari e Castoriadis, com o objetivo de identificar os processos de construção da subjetividade dos trabalhadores de saúde, propõe-se caminhos para a reforma dos sujeitos sociais nas práticas de saúde e como atores de um processo político de reforma.

  5. Lista preliminar dos Nematoda, Annelida e Chordata terrestres dos Açores

    OpenAIRE

    Paulo A V Borges

    2005-01-01

    Apresenta-se uma lista preliminar dos Filos Nematoda, Annelida e Chordata terrestres dos Açores. Com base na recente lista de espécies animais terrestres da Europa, projecto “Fauna Europaea” (http://www.faunaeur.org), listam-se 80 espécies de nemátodos e 21 espécies de anelídeos terrestres. As cerca de 49 espécies de vertebrados (Chordata) listados correspondem às espécies que se reproduzem nos Açores. ABSTRACT: A preliminary list of the Phyla Nematoda, Annelida and Chordata was compiled. ...

  6. Pituitary gland tumors

    International Nuclear Information System (INIS)

    This article gives an overview of the most common tumors of the pituitary gland and the differential diagnostics with special emphasis on radiological diagnostic criteria. A selective search of the literature in PubMed was carried out. Pituitary adenomas constitute 10-15 % of all intracranial tumors and are the most common tumors of the sellar region. Tumors smaller than 1 cm in diameter are called microadenomas while those larger than 1 cm in diameter are called macroadenomas. Approximately 65 % of pituitary gland adenomas secrete hormones whereby approximately 50 % secrete prolactin, 10 % secrete growth hormone (somatotropin) and 6 % secrete corticotropin. Other tumors located in the sella turcica can also cause endocrinological symptoms, such as an oversecretion of pituitary hormone or pituitary insufficiency by impinging on the pituitary gland or its stalk. When tumors spread into the space cranial to the sella turcica, they can impinge on the optic chiasm and cause visual disorders. A common differential diagnosis of a sellar tumor is a craniopharyngeoma. In children up to 10 % of all intracranial tumors are craniopharyngeomas. Other differential diagnoses for sellar tumors are metastases, meningiomas, epidermoids and in rare cases astrocytomas, germinomas or Rathke cleft cysts As these tumors are located in an anatomically complex region of the skull base and are often very small, a highly focused imaging protocol is required. The currently favored modality is magnetic resonance imaging (MRI) with the administration of a contrast agent. The sellar region should be mapped in thin slices. In cases of suspected microadenoma the imaging protocol should also contain a sequence with dynamic contrast administration in order to assess the specific enhancement characteristics of the tumor and the pituitary gland. (orig.)

  7. Skull Base Tumors

    Science.gov (United States)

    Schulz-Ertner, Daniela

    In skull base tumors associated with a low radiosensitivity for conventional radiotherapy (RT), irradiation with proton or carbon ion beams facilitates a safe and accurate application of high tumor doses due to the favorable beam localization properties of these particle beams. Cranial nerves, the brain stem and normal brain tissue can at the same time be optimally spared.

  8. What Is Wilms Tumor?

    Science.gov (United States)

    ... back wall of the abdomen (see picture). Each kidney is about the size of a fist. One kidney is just to ... functions. Many people in the United States live normal, healthy lives with just one kidney. Wilms tumors Wilms tumors are the most common ...

  9. Vanishing tumor in pregnancy

    Science.gov (United States)

    Vimal, M. V.; Budyal, Sweta; Kasliwal, Rajeev; Jagtap, Varsha S.; Lila, Anurag R.; Bandgar, Tushar; Menon, Padmavathy; Shah, Nalini S.

    2012-01-01

    A patient with microprolactinoma, who had two successful pregnancies, is described for management issues. First pregnancy was uneventful. During the second pregnancy, the tumor enlarged to macroprolactinoma with headache and blurring of vision which was managed successfully with bromocriptine. Post delivery, complete disappearance of the tumor was documented. PMID:23226664

  10. Vanishing tumor in pregnancy

    OpenAIRE

    Vimal, M. V.; Sweta Budyal; Rajeev Kasliwal; Jagtap, Varsha S.; Lila, Anurag R.; Tushar Bandgar; Padmavathy Menon; Nalini S. Shah

    2012-01-01

    A patient with microprolactinoma, who had two successful pregnancies, is described for management issues. First pregnancy was uneventful. During the second pregnancy, the tumor enlarged to macroprolactinoma with headache and blurring of vision which was managed successfully with bromocriptine. Post delivery, complete disappearance of the tumor was documented.

  11. Vanishing tumor in pregnancy

    Directory of Open Access Journals (Sweden)

    M V Vimal

    2012-01-01

    Full Text Available A patient with microprolactinoma, who had two successful pregnancies, is described for management issues. First pregnancy was uneventful. During the second pregnancy, the tumor enlarged to macroprolactinoma with headache and blurring of vision which was managed successfully with bromocriptine. Post delivery, complete disappearance of the tumor was documented.

  12. Parallel evolution of tumor subclones mimics diversity between tumors

    DEFF Research Database (Denmark)

    Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco;

    2013-01-01

    Intratumor heterogeneity (ITH) may foster tumor adaptation and compromise the efficacy of personalized medicines approaches. The scale of heterogeneity within a tumor (intratumor heterogeneity) relative to genetic differences between tumors (intertumor heterogeneity) is unknown. To address this, ...

  13. Tumor interstitial fluid

    DEFF Research Database (Denmark)

    Gromov, Pavel; Gromova, Irina; Olsen, Charlotta J.;

    2013-01-01

    secretion, non-classical secretion, secretion via exosomes and membrane protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for the discovery of molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper into...... the regulatory mechanisms and functions of secretion-related processes in tumor development. Secondly, the anomalous secretion of molecules that is innate to tumors and the tumor microenvironment, being associated with cancer progression, offers a valuable source for biomarker discovery and possible...... targets for therapeutic intervention. Here we provide an overview of the features of tumor-associated interstitial fluids, based on recent and updated information obtained mainly from our studies of breast cancer. Data from the study of interstitial fluids recovered from several other types of cancer are...

  14. Iatrogenic Tumor Implantation

    Institute of Scientific and Technical Information of China (English)

    Ying Ma; Ping Bai

    2008-01-01

    Iatrogenic tumor implantation is a condition that results from various medical procedures used during diagnosis or treatment of a malignancy. It involves desquamation and dissemination of tumor cells that develop into a local recurrence or distant metastasis from the tumor under treatment. The main clinical feature of the condition is nodules at the operation's porous channel or incision, which is easily diagnosed in accordance with the case history. Final diagnosis can be made based on pathological examination. Tumor implantation may occur in various puncturing porous channels, including a laparoscopic port, abdominal wall incision, and perineal incision, etc. Besides a malignant tumor,implantation potential exists with diseases, such as a borderline tumor and endometriosis etc. Once a tumor implantation is diagnosed, or suspected, surgical resection is usually conducted.During the diagnosis and treatment of diseases, avoiding and reducing iatrogenic implantation and dissemination has been regarded as an important principle for surgical treatment of tumors. In a clinical practice setting, if possible, excisional biopsy should be employed, if a biopsy is needed. Repeated puncturing should be avoided during a paracentesis. In a laparoscopic procedure, the tissue is first put into a sample bag and then is taken out from the point of incision. After a laparoscopic procedure, the peritoneum, abdominal muscular fasciae, and skin should be carefully closed, and/or the punctured porous channel be excised. In addition, the sample/tissue should be rinsed with distilled water before surgical closure of the abdominal cavity,allowing the exfoliated tumor cells to swell and rupture in the hypo-osmolar solution. Then surgical closure can be conducted following a change of gloves and equipment. The extent of hysteromyomectomy should as far as possible be away from the uterine cavity. The purpose of this study is to make clinicians aware of the possibility of tumor implantation

  15. Trabalho em saúde mental: vivências dos profissionais diante dos resultados

    Directory of Open Access Journals (Sweden)

    Vinicius Carvalho de Vasconcellos

    2012-12-01

    Full Text Available Considerando o cenário de consolidação da reforma psiquiátrica brasileira, este artigo investigou, no contexto dos trabalhadores da saúde mental, representações relativas ao papel profissional, às vivências diante dos resultados da assistência e às expectativas do futuro profissional da Saúde, tratando igualmente da possível ligação entre esses elementos. O material empírico foi coletado por meio de oito entrevistas semiestruturadas, realizadas em um Centro de Atenção Psicossocial brasileiro, e analisado principalmente pelo referencial teórico da psicossociologia francesa. De modo geral, os resultados sugerem que a vivência de realização diante dos resultados do trabalho vincula-se ao cumprimento do papel profissional, indicando também a ligação entre esses últimos elementos e as expectativas do futuro profissional. Na discussão e nas considerações finais, ressalta-se a concepção do trabalho por meio de seus limites intrínsecos como mecanismo que atenua a frustração profissional e analisam-se as implicações das vivências relativas aos resultados no vínculo subjetivo dos profissionais com o trabalho.

  16. Tumor endometrioide borderline de ovário em adolescente: relato de caso Borderline ovarian endometrioid tumor in adolescent: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Tamara Carvalho dos Santos

    2010-04-01

    Full Text Available Os tumores endometrioides malignos ovarianos são neoplasias epiteliais raras em pacientes jovens. Enquanto os carcinomas endometrioides ovarianos acometem mulheres na quinta e na sexta décadas de vida, os tumores borderline acometem mulheres em uma faixa etária mais ampla (de 22 a 77 anos. Descreveremos a seguir um caso raro de tumor endometrioide borderline ocorrendo em paciente de 16 anos. Desde que tumores do saco vitelino (TSV e de Sertoli-Leydig (TCSL podem mimetizar morfologicamente tumor endometrioide, o uso da imuno-histoquímica, além dos aspectos morfológicos, foi fundamental para estabelecer o diagnóstico diferencial entre essas condições.Malignant endometrioid ovarian tumors are rare epithelial neoplasias among young patients. Whereas endometrioid ovarian carcinomas are more common among women in their fifth and sixth decades of life, borderline endometrioid tumors affect 22 to 77 year-old women. The present study reports a rare case of borderline endometrioid tumor in a 16 year-old patient. Since yolk sac and Sertoli-Leydig cell tumor may morphologically mimic endometrioid tumor, both the use of immunohistochemistry and morphological aspects were essential to establish the differential diagnosis.

  17. THE TUMOR MACROENVIRONMENT: CANCER-PROMOTING NETWORKS BEYOND TUMOR BEDS

    Science.gov (United States)

    Rutkowski, Melanie R.; Svoronos, Nikolaos; Puchalt, Alfredo Perales; Conejo-Garcia, Jose R.

    2015-01-01

    During tumor progression, alterations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion to distal organs, and eventual metastatic disease. Distally produced hormones, commensal microbiota residing within mucosal surfaces, and myeloid cells and even the bone marrow impact the systemic immune system, tumor growth, and metastatic spread. Understanding the reciprocal interactions between the cells and soluble factors within the macroenvironment and the primary tumor will enable the design of specific therapies that have the potential to prevent dissemination and metastatic spread. This chapter will summarize recent findings detailing how the primary tumor and systemic tumor macroenvironment coordinate malignant progression. PMID:26216635

  18. The management of parotid tumors

    Institute of Scientific and Technical Information of China (English)

    Guang Yan Yu

    2008-01-01

    @@ The majority of salivary gland tumors are of epithelial origin. Parotid gland is the most common location of the tumors. Surgery is the main modality for the management of parotid tumors. Radiotherapy, chemotherapy etc are the auxiliary modalities.

  19. CT of parapharyngeal space tumors

    International Nuclear Information System (INIS)

    Five patients with parapharyngeal space tumors were examined with computed tomography (CT). They consisted of two parotid pleomorphic adenomas, and one neurilemmoma, neuroblastoma and Glomus vagale tumor respectively. The parapharyngeal space is divided into pre- or poststyloid compartments by the styloid process. Physical examinations and conventional radiographic examinations often fail to localize tumors in either compartment. However CT can divide the parapharyngeal space into two compartments by means of the styloid process. It is important to determine whether tumors are located in pre- or poststyloid compartments, because almost all prestyloid tumors are parotid gland tumors while poststyloid tumors include neurogenic tumors, lymphangioma, leiomyoma, lipoma, teratoma etc. In poststyloid tumors, contrast-enhanced CT may allow paragangliomas to be distinguished from other neurogenic tumors and other poststyloid tumors, e.g., lymphangioma and teratoma, because paragangioma shows marked enhancement whereas the other neurogenic tumors reveal moderate enhancement. (author)

  20. Scintiscans and carcinoid tumors

    International Nuclear Information System (INIS)

    The presence of somatostatin receptors on carcinoid tumors mediate imaging of tumor extent and inhibition of tumor's marker secretion and growth. This prospective study aimed to evaluate radiolabelled somatostatin analogues scans in the therapeutical work-up of carcinoids. Twenty-one patients with carcinoids underwent 26 scans with iodine octreotide or indium pentetreotide. The results for tumor and metastase imaging were analysed and compared to those of a short inhibition test of marker secretion and to those of MIBG scan. The sensitivity for imaging the overall 43 tumor sites was 72%. We had no false positive. Unknown tumors were discovered in three patients. The results were slightly better with indium pentetreotide and in metastase imaging. A positive scan did not always preclude responsiveness to the functional effect of octreotide. Results of somatostatin analogue scans were better than those with MBG. The two techniques showed complementary in one patient. Treatment decision making in patients with carcinoid tumors should benefit from functional inhibition test by octreotide as well as from indium pentreotide and MIBG scans. (authors). 21 refs., 2 figs., 1 tab

  1. Intraaxial brain tumors

    International Nuclear Information System (INIS)

    The incidence of primary intracranial tumors in the United States is approximately 15,0000 new cases per year. It has been estimated that 80--85% of all intracranial tumors occur in adults; the majority are situated in the supratentorial compartment. In the pediatric population, intracranial tumors are extraordinarily common---the CNS is the second most common site of pediatric neoplasia. Excluding the first year of life and adolescence, the location of intracranial tumors in the pediatric age group is infratentorial in 60--70% of cases, of which 75% involve the cerebellum and 25% reside in the brainstem. The limitations of neuroimaging are often revealed by understanding the microscopic pathology of these lesions, just as the neuropathologist would find if he or she relied solely on gross pathology. The general correlation between pathology and imaging will be stressed in this paper. Innumerable schemes for tumor classification have been devised; unfortunately, no classification is perfect. For the purposes of this discussion, the author has modified the proposed classifications of tumors in an attempt to combine typical neuroanatomic sites with the complex divisions traditionally formed on the basis of histopathology, since it is well recognized that the clinical behavior of brain tumors can depend largely on their sites of origin

  2. Adult brain tumors

    International Nuclear Information System (INIS)

    Radiotherapy plays an important role in the management of adults with brain tumors. This refresher course will focus on a wide variety of benign and malignant brain neoplasms and how contemporary radiotherapy affects survival. In each case the intent of radiation therapy is to destroy the neoplasm without affecting normal tissues. However, for many neoplasms serial post-treatment scans may show little change, and success is often measured more by absence of tumor progression than by scan normalization. Successful outcome after radiation therapy of brain tumors usually requires that (1) there is no tumor extension beyond the target volume, (2) adequate dose is delivered to the target volume, and (3) normal tissue tolerance doses are not exceeded. For some tumors it may be impossible to satisfy all three criteria. Three-dimensional treatment planning based on MRI or CT makes it possible to guarantee delivery of the full dose of radiation to gross tumor while minimizing the volume of normal tissue receiving high dose. Acceptable dose conformity can often be achieved with 2-4 static beams or arcs and are usually preferable to opposed lateral fields. Examples of planning solutions for a variety of tumor types, sizes, and anatomic location will be given. For some tumors, protocols involving substantial dose escalation require a large number of non-coplanar x-ray beams or particle therapy. Several concepts and techniques which relate to the treatment of brain tumors will be discussed, including conformal radiotherapy, brachytherapy, radiosurgery, fractionated stereotactic radiotherapy, altered fractionation, inverse treatment planning, re-irradiation and biologically effective dose (BED)

  3. Central nervous system tumors

    International Nuclear Information System (INIS)

    Central nervous system (CNS) tumors are relatively common in veterinary medicine, with most diagnoses occurring in the canine and feline species. Numerous tumor types from various cells or origins have been identified with the most common tumors being meningiomas and glial cell tumors. Radiation therapy is often used as an aid to control the clinical signs associated with these neoplasms. In general, these tumors have a very low metastatic potential, such that local control offers substantial benefit. Experience in veterinary radiation oncology would indicate that many patients benefit from radiation treatment. Current practice indicates the need for computed tomography or magnetic resonance imaging studies. These highly beneficial studies are used for diagnosis, treatment planning, and to monitor treatment response. Improvements in treatment planning and radiation delivered to the tumor, while sparing the normal tissues, should improve local control and decrease potential radiation related problems to the CNS. When possible, multiple fractions of 3 Gy or less should be used. The tolerance dose to the normal tissue with this fractionation schedule is 50 to 55 Gy. The most common and serious complications of radiation for CNS tumors is delayed radiation myelopathy and necrosis. Medical management of the patient during radiation therapy requires careful attention to anesthetic protocols, and medications to reduce intracranial pressure that is often elevated in these patients. Canine brain tumors have served as an experimental model to test numerous new treatments. Increased availability of advanced imaging modalities has spawned increased detection of these neoplasms. Early detection of these tumors with appropriate aggressive therapy should prove beneficial to many patients

  4. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  5. SURVIVIN AND TUMOR

    Institute of Scientific and Technical Information of China (English)

    宋文哲; 宋燕; 叶剑桥; 邱东涛

    2003-01-01

    As a new member of IAP (inhibitors of apoptosis protein) family, survivin has potent anti-apoptotic activities, and involves in the mitosis and angiogenesis. Researches have demonstrated that surviving is a tumor-specific anti-apoptotic factor, expressed in fetal tissues, and common human cancers, while not in normal, terminally differentiated adult tissues. The overexpression of survivin in tumor tissues is correlated with poor prognosis of the patients. Survivin can be used as a prognostic factor and a new target in tumor targeting therapy.

  6. Canine mast cell tumors.

    Science.gov (United States)

    Macy, D W

    1985-07-01

    Despite the fact that the mast cell tumor is a common neoplasm of the dog, we still have only a meager understanding of its etiology and biologic behavior. Many of the published recommendations for treatment are based on opinion rather than facts derived from careful studies and should be viewed with some skepticism. Because of the infrequent occurrence of this tumor in man, only a limited amount of help can be expected from human oncologists; therefore, burden of responsibility for progress in predicting behavior and developing treatment effective for canine mast cell tumors must fall on the shoulders of the veterinary profession. PMID:3929444

  7. Experimental model of ultrasound thermotherapy in rats inoculated with Walker-236 tumor Modelo experimental de termoterapia ultrassônica em ratos inoculados com tumor de Walker-236

    Directory of Open Access Journals (Sweden)

    José Antonio Carlos Otaviano David Morano

    2011-01-01

    Full Text Available PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted. Twenty male Wistar rats (160-300 g randomized in 2 equal groups (G-1: Control and G-2: Hyperthermia were inoculated with Walker-256 carcinosarcoma tumor. After 5 days G-2 rats were submitted to 45ºC hyperthermia. Heat was delivered directly to the tumor by an ultrasound (US equipment (3 MHz frequency, 1,5W/cm³. Tumor temperature reached 45º C in 3 minutes and was maintained at this level for 5 minutes. Tumor volume was measured on days 5, 8, 11, 14 e 17 post inoculation in both groups. Unpaired t-test was used for comparison. POBJETIVO: Desenvolver um modelo para avaliar os efeitos do ultra-som focal pulsado como fonte de calor para o tratamento de tumores de Walker subcutâneos implantados em ratos. MÉTODOS: Um estudo experimental, controlado, comparativo foi realizado. Vinte ratos Wistar machos (160-300 g divididos em dois grupos (G-1: Controle e G-2: hipertermia foram inoculados com tumor de Walker carcinossarcoma-256. Após cinco dias os ratos do grupo G-2 ratos foram submetidos a hipertermia (45ºC. O calor foi aplicado diretamente no tumor por um equipamento de ultrassonografia (3 MHz, 1,5 W/cm³. A temperatura no tumor atingiu 45ºC em 3 minutos e foi mantida nesse nível por 5 minutos. O volume do tumor foi medido nos dias 5, 8, 11, 14 e 17 após a inoculação, em ambos os grupos. Teste t não pareado foi utilizado para comparação. P <0,05 foi considerado significante. RESULTADOS: O volume do tumor foi significativamente maior no 5º dia e diminuiu nos dias 11, 14 e 17 nos ratos tratados. Animais submetidos à hipertermia sobreviveram mais tempo que os animais do grupo controle. No 29º dia após a inoculação do tumor, 40% dos ratos do grupo controle e 77,78% dos ratos tratados com

  8. Adaptation of GAMANAL to MS-DOS

    International Nuclear Information System (INIS)

    The public domain gamma spectrum analysis programme GAMANAL was adapted for use with personal computers running with MS-DOS or equivalent operating system. The original command structure of GAMANAL, and its algorithms were kept unchanged; the facilities to read spectra from different multichannel analyzer formats were added. In the completed PC version, GAMANAL runs in a batch mode, without graphics presentation or menu-oriented interaction with the operator. The operation and performance of the PC version of GAMANAL was compared with some commercial software, in respect to peak sensitivity, multiplet resolution, and accuracy of area determination. The study indicates that the GAMANAL analysis yields results as good or better than other programmes. 4 refs

  9. Panorama dos cursos de agroecologia no Brasil.

    OpenAIRE

    Balla, João Vitor Quintas; Massukado, Luciana Miyoko; Pimentel, Vania Costa

    2014-01-01

    Os cursos de agroecologia têm crescido nos últimos anos e sua introdução nas instituições de ensino se deu, em especial, a partir dos anos 2000. Desde então, diversos cursos são criados anualmente. No entanto, são poucos e dispersos os estudos que realizam uma análise quantitativa sistematizada sobre o ensino da agroecologia no Brasil. O objetivo deste estudo foi identificar os cursos em agroecologia, no âmbito da educação formal, que estão em funcionamento no Brasil, por região geográfica e ...

  10. Contabilidade criativa e responsabilidade dos auditores

    Directory of Open Access Journals (Sweden)

    Ariovaldo dos Santos

    2003-08-01

    Full Text Available Nos contextos nacional e internacional da profissão contábil, o auditor tem exercido um papel fundamental. A atividade profissional do auditor independente tem ajudado a impulsionar o desenvolvimento dos mercados, além de contribuir para o estabelecimento da ordem socioeconômica mundial. Na visão dos usuários externos da informação contábil, e dos próprios clientes, a atuação do auditor é sinônimo de confiança e credibilidade. Nos últimos meses, a onda de escândalos contábeis, com grandes empresas de auditoria envolvidas, e até sentenciadas (no caso Enron, a Andersen foi considerada culpada, por um Júri de Houston - Texas, pela destruição de documentos, marcou a atividade profissional dos auditores e parece ter mudado a visão de responsabilidade desses profissionais sobre esses fatos. No presente artigo são estudados e apresentados alguns conceitos fundamentais relacionados com o fenômeno da contabilidade criativa, assim como os fatores que induzem sua utilização, dentre os quais pode-se destacar: valores éticos, morais e vácuos ou flexibilidade normativa. Tais fatores acabam por funcionar como catalisadores da engenharia contábil no desenho das demonstrações contábeis e passam a atender os interesses de quem as elabora em vez de buscar a imagem fidedigna do patrimônio.In the national and international contexts of professional accounting, the auditor has played a fundamental role. The professional activity of the independent auditor has both helped to encourage market development and contributed to the establishment of a global socio-economic order.From the point of view of the external users of accounting information and the clients themselves, the professional activity of the auditor is a synonym of trust and credibility. In the last few months, the wave of financial scandals involving large auditing companies, some of which were even convicted for their demonstrated - direct and indirect - intervention in

  11. La larga vida de dos rocas orensanas

    Directory of Open Access Journals (Sweden)

    García Quintela, Marco V.

    2011-12-01

    Full Text Available We study two rocks, a rock carving and a «rocky sanctuary » from the Ourense province (Spain, with two complementary methodologies, landscape archeology and «biography» (Kopytoff of objects. We start with their description in Christian texts, and then we observe that their relation with important hillforts forms a localization pattern, and finally we propose to date that relationship in the Iron Age. This chronology of the rocks and the following Christian reevaluation leads towards their «social life». These analyses are pertinent in the current debate about the chronology of the Galician rock art, and we propose that the use and meaning in the long term is as important as the initial moment of the carving.Se estudian dos rocas, un petroglifo y un «santuario rupestre » de la provincia de Ourense, con dos metodologías complementarias, la arqueología del paisaje y la «biografía» (Kopytoff de los objetos. Partiendo de su descripción en textos cristianos se considera el patrón de localización que conforman en relación con castros importantes, relación que se propone fechar en la Edad del Hierro. Esta adscripción cronocultural y su posterior resemantización cristiana lleva a la consideración de su «vida social». Estas aproximaciones inciden en el debate sobre la datación del arte rupestre en Galicia y se propone que, más allá del momento de grabado inicial, se estudie su uso y sentido en la larga duración.

  12. Conjunctival tumors in children: histopathologic diagnosis in 165 cases

    Directory of Open Access Journals (Sweden)

    Martin A. Zimmermann-Paiz

    2015-12-01

    Full Text Available ABSTRACT Purpose: Conjunctival tissue tumors have a varied presentation, and few series studies on pediatric patients have been published. The objective of this paper is to report the histopathologic diagnoses (spanning over 1988-2013 of conjunctival tumors in children younger than 14 years. Methods: We conducted a retrospective, descriptive, and observational study by reviewing the database of all children in whom a conjunctival tumor was surgically removed at Hospital de Ojos y Oídos "Dr. Rodolfo Robles V.," Benemérito Comité Pro Ciegos y Sordos de Guatemala. The data pertaining to gender, age, and histopathologic diagnosis of all cases was collected. The same ocular pathologist made all diagnoses. Results: One hundred sixty-five cases were found, with a mean age of 7.88 years, being 91 (55.15% male subjects. Melanocytic lesions were the most common tumors found (30.91% of cases, with only one case (0.60% being malignant. Conclusions: Melanocytic lesions were the most common tumors found, and of all the cases, only one was malignant; this was in a patient with xeroderma pigmentosum. These findings are consistent with those reported in other studies regarding the frequencies of the histopathology of conjunctival tumors in the pediatric population.

  13. Dos sentencias distantes y una convención verdadera

    OpenAIRE

    Domenech, Ernesto E.

    2014-01-01

    He aquí dos sentencias, de dos países distintos (Colombia y Argentina), de dos infancias discernibles (una sin padres ni familia al alcance, otra con padres en conflicto y con facebook) de niños y jóvenes de edades diversas (uno de 4 años, otro adolescente). He aquí también dos fueros disímiles (uno penal, el otro civil), con distintos derechos internos y una misma Convención Internacional de Derechos del Niño. La diversidad y la comparación inquietan. El lenguaje claro de las sentencias a...

  14. Pituitary tumors containing cholecystokinin

    DEFF Research Database (Denmark)

    Rehfeld, J F; Lindholm, J; Andersen, B N;

    1987-01-01

    We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained...

  15. Renal tumors in infancy

    International Nuclear Information System (INIS)

    The classification of childhood renal masses in updated, including the clinical signs and imaging techniques currently employed to confirm their presence and type them. Several bening and malignant childhood tumors are described in substantial detail. (Author) 24 refs

  16. Stages of Wilms Tumor

    Science.gov (United States)

    ... of Childhood Treatment for more information. Primary Renal Synovial Sarcoma Primary renal synovial sarcoma is a rare tumor ... multilocular cystic nephroma usually includes: Surgery . Primary Renal Synovial Sarcoma Treatment of primary renal synovial sarcoma usually includes: ...

  17. Modulation of tumor oxygenation

    International Nuclear Information System (INIS)

    There is a large body of evidence suggesting that deficiencies in the O2 supply of tumors exist due to restrictions (i) in the O2 delivery by perfusion and/or diffusion, and (ii) in the O2 transport capacity. Whereas the former are mostly based on inadequate and heterogeneous microcirculatory functions, the latter are predominantly due to tumor-associated anemia. Possible uses and limitations of measures are discussed which can increase the microvascular O2 content and thus may preferentially serve to enhance diffusion-limited O2 availability. In addition, means are described for improving and increasing the uniformity of microcirculation thus possibly enhancing perfusion-limited O2 delivery. Reducing cellular respiration rate should be of benefit in both pathophysiological conditions. Because both types of O2 limitation coexist in solid tumors, appropriate combinations should be aimed at eradicating tumor hypoxia which is present in at least one third of cancers in the clinical setting

  18. Children's Tumor Foundation

    Science.gov (United States)

    ... Registry Learn About NF Facts & Statistics NF1 NF2 Schwannomatosis About Us Foundation News & Events Employment Opportunities About ... Children's Tumor Foundation Home - Neurofibromatosis, NF, NF1, NF2, Schwannomatosis What Is NF? Facts & Statistics Schwannomatosis Diagnosis of ...

  19. What Are Pituitary Tumors?

    Science.gov (United States)

    ... too little makes you sluggish. If a pituitary tumor makes too much TSH, it can cause hyperthyroidism (an overactive thyroid gland). Adrenocorticotropic hormone (ACTH, also known as corticotropin ) causes ...

  20. Understanding Brain Tumors

    Science.gov (United States)

    ... Our Mission Advance Research Clinical Trial Endpoints Defeat GBM Oligo Research Fund Pediatric Initiatives Funded Research & Accomplishments ... no symptoms when their brain tumor is discovered Recurrent headaches Issues with vision Seizures Changes in personality ...

  1. Brain Tumor Risk Factors

    Science.gov (United States)

    ... for example), unusual symptoms such as headaches or short-term memory loss can be investigated with your family history in mind. Click here to view our webinars on Causes and Risk Factors of Brain Tumors. Additional information ...

  2. Overview of Heart Tumors

    Science.gov (United States)

    ... flow, and has grown into the surrounding tissue, heart transplantation may be required. Transplantation is very rarely done ... and only noncancerous tumors are typically considered for heart transplantation. Mechanical cardiac support might be considered until doctors ...

  3. Brain Tumor Statistics

    Science.gov (United States)

    ... About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Press Releases Headlines Newsletter ABTA ... About Us Our Founders Board of Directors Staff Leadership Strategic Plan Financials News Careers Brain Tumor Information Brain ...

  4. Ovarian tumors secreting insulin.

    Science.gov (United States)

    Battocchio, Marialberta; Zatelli, Maria Chiara; Chiarelli, Silvia; Trento, Mariangela; Ambrosio, Maria Rosaria; Pasquali, Claudio; De Carlo, Eugenio; Dassie, Francesca; Mioni, Roberto; Rebellato, Andrea; Fallo, Francesco; Degli Uberti, Ettore; Martini, Chiara; Vettor, Roberto; Maffei, Pietro

    2015-08-01

    Combined ovarian germ cell and neuroendocrine tumors are rare. Only few cases of hyperinsulinism due to ovarian ectopic secretion have been hypothesized in the literature. An ovarian tumor was diagnosed in a 76-year-old woman, referred to our department for recurrent hypoglycemia with hyperinsulinism. In vivo tests, in particular fasting test, rapid calcium infusion test, and Octreotide test were performed. Ectopic hyperinsulinemic hypoglycemia was demonstrated in vivo and hypoglycemia disappeared after hysteroadnexectomy. Histological exam revealed an ovarian germ cell tumor with neuroendocrine and Yolk sac differentiation, while immunostaining showed insulin positivity in neuroendocrine cells. A cell culture was obtained by tumoral cells, testing Everolimus, and Pasireotide. Insulin was detected in cell culture medium and Everolimus and Pasireotide demonstrated their potentiality in reducing insulin secretion, more than controlling cell viability. Nine cases of hyperinsulinism due to ovarian ectopic secretion reported in literature have been reviewed. These data confirm the ovarian tissue potentiality to induce hyperinsulinemic hypoglycemic syndrome after neoplastic transformation. PMID:25896552

  5. Adrenocortical tumors in children

    Directory of Open Access Journals (Sweden)

    R.C. Ribeiro

    2000-10-01

    Full Text Available Childhood adrenocortical tumors (ACT are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer (p53 mutations and selected genetic syndromes (Beckwith-Wiedemann syndrome have been associated with childhood ACT in general but not with the Brazilian counterpart. Most of the affected children are young girls with classic endocrine syndromes (virilizing and/or Cushing. Levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (DHEA-S, which are abnormal in approximately 90% of the cases, provide the pivotal clue to a diagnosis of ACT. Typical imaging findings of pediatric ACT consist of a large, well-defined suprarenal tumor containing calcifications with a thin capsule and central necrosis or hemorrhage. The pathologic classification of pediatric ACT is troublesome. Even an experienced pathologist can find it difficult to differentiate carcinoma from adenoma. Surgery is the single most important procedure in the successful treatment of ACT. The role of chemotherapy in the management of childhood ACT has not been established although occasional tumors are responsive to mitotane or cisplatin-containing regimens. Because of the heterogeneity and rarity of the disease, prognostic factors have been difficult to establish in pediatric ACT. Patients with incomplete tumor resection or with metastatic disease at diagnosis have a dismal prognosis. In patients with localized and completely resected tumors, the size of the tumor has predictive value. Patients with large tumors have a much higher relapse rate than those with small tumors.

  6. Pituitary tumors containing cholecystokinin

    DEFF Research Database (Denmark)

    Rehfeld, J F; Lindholm, J; Andersen, B N;

    1987-01-01

    We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained......'s disease and 7 acromegaly with adenomas containing ACTH. The cholecystokinin peptides from the tumors were smaller and less sulfated than cholecystokinin from normal pituitary glands. We conclude that ACTH-producing pituitary cells may also produce an altered form of cholecystokinin....

  7. Radioembolization of hepatic tumors

    OpenAIRE

    Kennedy, Andrew

    2014-01-01

    Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 (90Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This ...

  8. Odontogenic tumors: analysis of 127 cases Tumores odontogênicos: análise de 127 casos

    Directory of Open Access Journals (Sweden)

    Jean Nunes SANTOS

    2001-12-01

    Full Text Available One hundred and twenty-seven cases of histologically confirmed odontogenic tumors were retrieved from a total of 5,289 oral and maxillary lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, during a period of 30 years (l970-l999. The most common histological diagnosis was odontoma (50.40%, followed by ameloblastoma (30.70%. The prevalence of odontogenic tumors was greater in females and the peak incidence occurred in the second and third decades of life. The main anatomical location was the mandible, and no malignant tumors were found.De uma série de 5.289 casos de lesões orais e dos maxilares diagnosticadas no Laboratório de Patologia Oral da Faculdade de Odontologia da Universidade Federal do Rio Grande do Norte no período de 30 anos (1970-1999, foram analisados 127 casos de tumores odontogênicos confirmados histologicamente. A lesão mais freqüente foi o odontoma (50,40% seguida pelo ameloblastoma (30,70%. A prevalência de tumores odontogênicos foi maior nas mulheres e o pico de incidência ocorreu na segunda e terceira décadas de vida. A localização anatômica mais comum foi a mandíbula e não foram encontrados casos de tumores malignos.

  9. Estudo dos líquenes dos Açores. Parte 1 - Caldeira do Faial

    OpenAIRE

    Purvis, Ole W.; James, Peter W.

    1993-01-01

    Este trabalho, o primeiro de uma série sobre a taxonomia, ecologia e biogeografia dos líquenes dos Açores, descreve a flora de líquenes que ocorrem na cratera da Caldeira do Faial. Correspondendo a uma zonação em altitude foram reconhecidas três zonas distintas de líquenes na Caldeira. (1) Uma zona superior, entre 922-800 m, pobre em líquenes e dominada por briófitos. (2) Uma zona média, entre 800-600 m, relativamente rica em espécies e com uma fácies distintiva de Lobarion. (3) Uma zona infe...

  10. A sociedade dos povos como solução dos conflitos internacionais

    Directory of Open Access Journals (Sweden)

    Guilherme Pinto Ravazi

    2015-06-01

    Full Text Available RESUMO O objetivo deste artigo é estabelecer o estado de coisas do problema dos conflitos internacionais. Em seguida, apresentar o projeto iluminista de Kant n’A Paz Perpétua que propõe uma série de princípios para o estabelecimento de uma Federação da Paz. Por fim, expor o projeto de Rawls no Direito dos Povos como uma solução para os conflitos internacionais. ABSTRACT The aim of this paper is to discribe the state of affairs of the issue of international conflicts. Then I present Kant’s Enlightenment project in Perpetual Peace, which proposes a series of principles for the establishment of a pacific federation. Finally, I present Rawls’ project in The Law of Peoples as a solution to international conflicts.

  11. Aplicações da teoria dos sistemas à teoria dos códigos

    OpenAIRE

    Rodrigues, Duarte Polónia

    2012-01-01

    Os códigos the Reed Solomon são códigos cíclicos não binários com símbolos de código num corpo de Galois. Eles foram descobertos em 1960 por L. Reed e G. Solomon. Nas décadas após a sua descoberta, os códigos de RS gozaram de inúmeras aplicações. Este trabalho é maioritariamente focado nos algoritmos de codi cação e descodi cação dos códigos RS, analisando uma relação entre a teoria dos códigos e uma técnica de identi cação desenvolvida no âmbito da abordagem comportamental...

  12. Neurobiologia dos transtornos do controle dos impulsos The neurobiology of impulse control disorders

    Directory of Open Access Journals (Sweden)

    Wendol A Williams

    2008-05-01

    Full Text Available OBJETIVO: Revisar os artigos sobre substratos neurobiológicos dos transtornos do controle dos impulsos. O jogo patológico é o foco central desta revisão na medida em que a maioria dos estudos biológicos dos formalmente classificados como transtornos do controle dos impulsos examinou este transtorno. MÉTODO: Foi feita uma busca no banco de dados Medline de artigos publicados de 1966 até o presente para identificar aqueles relevantes para serem revisados neste artigo. DESFECHOS: Estudos pré-clínicos sugerem que a neuromodulação das monoaminas cerebrais está associada à tomada de decisões impulsivas e aos comportamentos de risco. Os estudos clínicos implicam diversos sistemas de neurotransmissores (serotoninérgico, dopaminérgico, adrenérgico e opióide na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. Estudos de neuroimagem preliminares têm indicado o córtex pré-frontal ventromedial e o estriato ventral como atuantes na fisiopatologia do jogo patológico e de outros transtornos do controle dos impulsos. As contribuições genéticas para o jogo patológico parecem substanciais e os estudos iniciais têm relacionado esse transtorno a polimorfismos alélicos específicos, ainda que os achados de varredura genômica ainda tenham que ser publicados. CONCLUSÃO: Mesmo que tenham sido logrados avanços significativos em nossa compreensão sobre os transtornos do controle dos impulsos, mais pesquisas são necessárias para ampliar o conhecimento existente e traduzir esses achados em avanços clínicos.OBJECTIVE: To review the neurobiological substrates of impulse control disorders. Pathological gambling is a main focus of the review in that most biological studies of the formal impulse control disorders have examined this disorder. METHOD: The medical database Medline from 1966 to present was searched to identify relevant articles that were subsequently reviewed to generate this manuscript

  13. Reclamações dos utentes : estudo dos resultados e medidas correctivas no contexto dos Agrupamentos de Centros de Saúde de Lisboa e Vale do Tejo

    OpenAIRE

    Moçozinho, Pedro Morgado

    2015-01-01

    RESUMO - A qualidade dos cuidados de saúde, evolui ao longo dos tempos e é agora considerada um direito e um pilar fundamental nos serviços de saúde. As reclamações dos utentes podem revelar informação acerca das experiências entre os utentes e as organizações de saúde. Desta forma as reclamações podem ser consideradas como indicadores de qualidade que permitem identificar áreas e/ou oportunidades de melhoria, e de grande representatividade no processo da melhoria contínua da qualidade na saú...

  14. Adult brain tumors

    International Nuclear Information System (INIS)

    Radiotherapy plays an important role in the management of adults with brain tumors. This refresher course will focus on a variety of benign and malignant brain neoplasms and how contemporary radiotherapy affects outcome. Successful outcome after radiotherapy requires that (1) there is no tumor extension beyond the selected target volume, (2) adequate dose is delivered to the target volume, and (3) normal tissue tolerance dose is not exceeded. For many neoplasms serial post-treatment scans may show little change, and success is often measured more by absence of tumor progression than by scan normalization. Three-dimensional treatment planning based on MRI or CT makes it possible to guarantee delivery of the full prescription dose to gross tumor while minimizing the volume of normal tissue receiving high dose. Acceptable dose conformity can often be achieved with 2-4 static beams or arcs, which is usually preferable to opposed lateral fields. Protocols involving substantial dose escalation require a large number of non-coplanar x-ray beams or particle therapy. This course will cover important concepts and techniques which relate to the treatment of brain tumors, including conformal radiotherapy, brachytherapy, radiosurgery, fractionated stereotactic radiotherapy, altered fractionation, inverse treatment planning, re-irradiation, and biologically effective dose (BED). Examples of planning solutions for a variety of tumor types, size and anatomical locations will be given

  15. [Grading of neuroendocrine tumors].

    Science.gov (United States)

    Saeger, W; Schnabel, P A; Komminoth, P

    2016-07-01

    The current WHO classification of neuroendocrine tumors (NET) differentiates between typical carcinoids (low grade NET), atypical carcinoids (intermediate grade NET) and small cell and large cell carcinomas (high grade NET) according to the prognosis. Neuroendocrine neoplasms (NEN) of the gastrointestinal tract and the pancreas are graded in an identical way. Together with the TNM system this enables a preoperative estimation of the prognosis in biopsies and fine needle aspirates. Well-differentiated tumors are graded into G1 tumors by the number of mitoses, tumors (2-20 mitoses/10 HPF, Ki-67 3-20 %). Discrepancies between the number of mitoses and the Ki-67 index are not uncommon and in these cases the higher value of the two should be applied. The more differentiated tumors of the G3 type have to be differentiated from undifferentiated carcinomas of the small cell type and large cell type with a much poorer prognosis. Prognosis relevant grading of thyroid cancers is achieved by special subtyping so that the G1-G3 system is not applicable. The rare cancers of the parathyroid gland and of the pituitary gland are not graded. Adrenal tumors also have no grading system. The prognosis is dependent on the Ki-67 index and with some reservations on the established scoring systems. PMID:27379621

  16. Towards tumor immunodiagnostics

    Science.gov (United States)

    Kotoula, Vassiliki

    2016-01-01

    Immunodiagnostic markers applicable on tissue or cytologic material may be prognostic or predictive of response to immunomodulatory drugs and may also be classified according to whether they are cell-specific or tumor-tissue-specific. Cell-specific markers are evaluated under the microscope as (I) morphological, corresponding to the assessment of tumor infiltrating immune cells on routine hematoxylin & eosin (H&E) sections; and (II) immunophenotypic, including the immunohistochemical (IHC) assessment of markers characteristic for tumor infiltrating immune cells. Tumor-tissue-specific markers are assessed in tissue extracts that may be enriched in neoplastic cells but almost inevitably also contain stromal and immune cells infiltrating the tumor. Such markers include (I) immune-response-related gene expression profiles, and (II) tumor genotype characteristics, as recently assessed with large-scale genotyping methods, usually next generation sequencing (NGS) applications. Herein, we discuss the biological nature of immunodiagnostic markers, their potential clinical relevance and the shortcomings that have, as yet, prevented their clinical application. PMID:27563650

  17. Towards tumor immunodiagnostics.

    Science.gov (United States)

    Kourea, Helen; Kotoula, Vassiliki

    2016-07-01

    Immunodiagnostic markers applicable on tissue or cytologic material may be prognostic or predictive of response to immunomodulatory drugs and may also be classified according to whether they are cell-specific or tumor-tissue-specific. Cell-specific markers are evaluated under the microscope as (I) morphological, corresponding to the assessment of tumor infiltrating immune cells on routine hematoxylin & eosin (H&E) sections; and (II) immunophenotypic, including the immunohistochemical (IHC) assessment of markers characteristic for tumor infiltrating immune cells. Tumor-tissue-specific markers are assessed in tissue extracts that may be enriched in neoplastic cells but almost inevitably also contain stromal and immune cells infiltrating the tumor. Such markers include (I) immune-response-related gene expression profiles, and (II) tumor genotype characteristics, as recently assessed with large-scale genotyping methods, usually next generation sequencing (NGS) applications. Herein, we discuss the biological nature of immunodiagnostic markers, their potential clinical relevance and the shortcomings that have, as yet, prevented their clinical application. PMID:27563650

  18. O pensamento inaugural dos direitos humanos pelas lições dos sofistas

    Directory of Open Access Journals (Sweden)

    Hilda Helena Soares Bentes

    2009-12-01

    Full Text Available Propõe-se a analisar as primeiras manifestações de um pensamento  igualitário, base   dos direitos do homem na filosofia jurídica moderna, através do debate travado entre as concepções de phýsis e nómos, iniciado pelos pré-socráticos e desenvolvido intensamente pelos sofistas.

  19. A exploração sustentada dos recursos naturais no Arquipélago dos Bijagós

    OpenAIRE

    João MADEIRA

    2011-01-01

    Considera-se pertinente este estudo sobre a exploração sustentada dos recursos naturais no Arquipélago dos Bijagós, dada a sua localização estratégica na geografia atlântica e a sua vulnerabilidade às influências externas que afectam o seu equilíbrio secular. Desde 1975 a sociedade guineense tem sido responsável pela utilização descontrolada dos recursos naturais, sobretudo na zona costeira. O Arquipélago tem suscitado numerosos interesses, muitos dos quais incompatíveis com a garantia de um ...

  20. A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor

    OpenAIRE

    Omer Alici; Musa Kemal Keles; Alper Kurt

    2015-01-01

    Proliferating trichilemmal tumors (PTTs) are neoplasms derived from the outer root sheath of the hair follicle. These tumors, which commonly affect the scalp of elderly women, rarely demonstrate malignant transformation. Although invasion of the tumors into neighboring tissues and being accompanied with anaplasia and necrosis are accepted as findings of malignancy, histological features may not always be sufficient to identify these tumors. The clinical behavior of the tumor may be incompatib...

  1. Tumor diagnosis, grading, and staging

    International Nuclear Information System (INIS)

    Optimal use of radiation therapy for the treatment of animal tumors necessitates accurate clinical evaluation, diagnostic imaging, and pathology. This requires a coordinated effort between the clinical and radiation oncologist, radiologist, and pathologist. The histological appearance of the tumor, tumor grade, and tumor stage are important diagnostic criteria that need to be established. Diagnostic imaging, including radiographic, computerized tomographic, magnetic resonance imaging, and ultrasound studies are helpful in establishing an accurate tumor location and diagnosis. Biopsy and histological examination of tumor tissue are necessary for final diagnosis of tumor type. Determination of tumor type is critical because different tumor types vary in regard to radiosensitivity, local behavior, and propensity for regional and systemic metastasis. The histological grade of many tumors is an important indicator of the potential for local invasion or systemic metastases, and may influence treatment response. Tumor staging as determined by clinical evaluation, imaging studies, and histological evaluation is necessary to establish the extent of the tumor, both locally, regionally, and systemically. The clinical oncologist should have an understanding of the procedures involved in tumor diagnosis, tumor grading, and tumor staging. This provides a better understanding of the neoplastic condition and recognition of the limitations of diagnostic procedures. Tumor type, grade, and stage all impact radiation treatment planning and the need for adjuvant regional or systemic therapy

  2. Dois estudos sobre o trabalho dos petroleiros

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    Leda Leal Ferreira

    1996-06-01

    Full Text Available O presente artigo traz um resumo de dois estudos realizados na área do petróleo, o primeiro feito em uma unidade de refino e o segundo abarcando o trabalho de operadores exercendo várias funções dentro de uma refinaria e de terminais marítimos de petróleo. Nos dois casos, o ponto central foi a análise da atividade dos trabalhadores, isto é, o que eles faziam e como o faziam para dai conta das exigências de produção que lhes eram atribuídas. No entanto, os métodos utilizados foram diferentes: no primeiro caso utilizou-se a Análise Ergonômica do Trabalho (AET e no segundo, a Análise Coletiva do Trabalho (ACT. Além de apresentar os principais resultados destes estudos, a autora faz considerações sobre as diferenças entre os dois métodos e um apelo à comunidade científica para que se preocupe mais em estudar a atividade real dos trabalhadores e assim contribuir para um melhor conhecimento do que se passa no interior das unidades produtivas, evitando que sofrimentos humanos inúteis e até catástrofes industriais continuem a ocorrer.This paper describes two studies about petroleum industry. The first was developed in a refinery and the second focuses on the work of operators in various jobs within a refinery and maritime petroleum units. In both cases, the focal point was the analyses of activities, that is, what the workers do and how they do it in order to meet production demandai put on them. However, two different methods were applied in the studies. Ergonomics Work Analyses (EWA was used on the first case and Collective Work Analyses (CWA, on the second. Besides showing the main results, the author compares the two methods. She also draws the scientific community attention to the importance of studding the workers actual activity in order to contribute to a better understanding of what is going on inside production units, avoiding useless human suffering, and the still ocurring undustrial disasters.

  3. O EQUIVALENTE EM CARBONATO DE CÁLCIO DOS CORRETIVOS DA ACIDEZ DOS SOLOS

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    J.C. ALCARDE

    1996-05-01

    Full Text Available Os corretivos da acidez dos solos podem ter dois equivalentes em carbonato de cálcio: um, calculado pelos teores de cálcio e magnésio utilizando a expressão: % CaO x 1,79 + % MgO x 2,48 = %ECaCO3; outro, determinado analiticamente pelo poder ou valor de neutralização. Para uma mesma amostra ambos os valores deveriam coincidir, o que raramente acontece. Diversas hipóteses foram levantadas para justificar essa diferença. Os resultados deste trabalho permitiram inferir que nem todo o cálcio e magnésio dos corretivos devem estar associados às bases quimicamente efetivas mas também a fosfato, sulfato ou outras bases de forças inexpressivas; também os constituintes neutralizantes podem estar aprisionados em cristais de outros componentes dos corretivos, como sílica por exemplo, que só são atingidos por um ataque mais enérgico da amostra. Como conclusão, a avaliação química atual dos corretivos da acidez dos solos pode não estar se compatibilizando com o comportamento agrícola desses produtos.Agricultural liming materials can have two calcium carbonate equivalents: one calculated in function of calcium and magnesium oxide percentages, by the expression: % CaO x 1,79 + % MgO x 2,48 = %ECaCO3; and the other determined analytically by the neutralization power or value. For one sample, both values should be similar, however, this rarely occurs. Several hypoteses were raised to justify the difference. Results of this research permit to infer that not all calcium and magnesium should be associated to the chemically effective bases, but they are also associated to phosphate, sulphate or other bases of inexpressive strength. It is also possible that, the neutralizing components could be captured inside cristals, like silica for example, which react only after a strong solubilization of the sample. It is concluded that the chemical evaluation of agricultural liming materials at the present time cannot explain the agronomical behaviour of

  4. Identificação dos insulinomas pela ecoendoscopia Identification of insulinomas by endoscopic ultrasonography

    Directory of Open Access Journals (Sweden)

    José Celso Ardengh

    2004-04-01

    Full Text Available OBJETIVO: Demonstrar a sensibilidade da ecoendoscopia (EE no diagnóstico pré-operatório dos insulinomas e comparar com outros testes diagnósticos como tomografia helicoidal e ressonância magnética. MÉTODOS: Trinta pacientes foram examinados prospectivamente pela ecoendoscopia com o diagnóstico clínico de insulinoma antes de serem submetidos ao tratamento cirúrgico. O exame ecoendoscópico sempre foi precedido pelo US, TC helicoidal e em 10 pacientes pela RM. Em 12 casos foi indicada a punção aspirativa com agulha fina eco-guiada para confirmar a suspeita de insulinoma. RESULTADOS: A sensibilidade da EE na identificação dessas lesões foi de 86,6% (26/30 tumores. Vinte e seis tumores foram benignos (86,6% e quatro malignos (13,4%. Realizamos punção biópsia aspirativa em 12 pacientes (40% e o diagnóstico histológico foi feito em 10/12 pacientes (83,3%. Nessa casuística, 25 tumores foram menores que 2 cm (83,3% e cinco maiores que 2 cm (16,7%. Os tumores detectados pela EE tinham tamanho médio de 1,5 cm (0,6 a 5,4 cm. A identificação dos tumores pela EE na cabeça, corpo e cauda foi de 100%, 100% e 55,5%, respectivamente. CONCLUSÃO: A EE tem alta sensibilidade na identificação e localização dessas lesões e deve ser recomendada quando os métodos tradicionais de imagem empregados falham no diagnóstico. A PAAF é uma tentativa para evitarmos falso-positivos.BACKGROUND: The aim of this study is to compare EUS and the others diagnostics tests in the correct localization of insulinomas. METHODS: We prospectively investigated 30 patients with endoscopic ultrasound with a clinical diagnosis of insulinomas prior to surgical exploration. They were submitted to abdominal ultrasonography, spiral computed tomography and four patients were submitted to magnetic ressonance before EUS. Surgery was the gold standard for tumor localization. RESULTS: Twenty-six tumors were benign (86.6% and four were malign (13.4%. The median size

  5. Assessment of impact of a severe accident at nuclear power plant of Angra dos Reis with release of radionuclides to the atmosphere; Avaliacao do impacto de um acidente severo na usina de Angra dos Reis com liberacao de radionuclideos para a atmosfera

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, Andre Silva de

    2015-07-01

    This study had as purpose the assess the impact of a severe accident, and also analyze the dispersion of {sup 131}I in the atmosphere, so that, through concentrating and inhaling dose of the plume, were possible to verify if the results are in accordance with the indicated data by the Plan of Emergency of the CNAAA regarding the Impact Zone and Control. This exercise was performed with the aid of an atmospheric model and a dispersion where to atmospheric modeling we used the data coupling WRF / CALMET and of dispersion, CALPUFF. The suggested accident consists of a Station Blackout at Nuclear Power of Angra (Unit 1), where through the total core involvement, will release 100% of the {sup 131}I to the atmosphere. The value of the total activity in the nucleus to this radionuclide is 7.44 x 1017 Bq, that is relative on the sixth day of burning. This activity will be released through the chimney at a rate in Bq/s in the scenario of 12, 24, 48 and 72 hours of release. Applying the model in the proposed scenario, it is verified that the plume has concentrations of the order of 1020 Bq/m³ and dose of about 108 Sv whose value is beyond of the presented by Eletronuclear in your current emergency plan. (author)

  6. Evaluation of conventional x-ray diagnostic equipment and radiological protection systems of hospitals and clinics installed in Recife city, Brazil; Avaliacao dos equipamentos de raios-X diagnostico convencionais e dos sistemas de protecao radiologica de clinicas e hospitais da cidade de Recife

    Energy Technology Data Exchange (ETDEWEB)

    Passos, Robson Silva

    1999-05-15

    Diagnostic radiology is the main contributor to the man-made exposure of general population. Since Quality Assurance (QA) programs ensure high quality diagnostic images with the lowest possible radiation dose to the patient, it has been recommended that all introduce QA programs for their radiological facilities. Consequently it is important to check the adequacy of equipment operating parameters in diagnostic radiography facilities, to ensure that a high quality of service is delivered. The purpose of this study was to evaluate the operating conditions of diagnostic units installed in Recife, Pernambuco. The study included 31 X-ray units from both public and private diagnostic services. The following parameters were evaluated: coincidence between the luminous and radiation fields; alignment of the radiation beam; agreement between the real and preset values of kVp and exposure time; filtration; half value lower (HVL); luminance of the view box; uniformity of the luminance; illuminance of the environment. The results showed that 20% of the equipment surveyed exhibited discrepancies between the luminous and radiation fields greater than 2% of the source to skin distance. The test of kilovoltage showed that 48% of the units do not fulfill the acceptability criteria, presenting discrepancies higher than {+-} 10% between the measured and preset values. The results of the accuracy of the timer indicated that 81% of the equipment surveyed present a discrepancy greater than {+-} 10% between the time selected in the control panel and actual exposure time.The test of the filtration shown that, in 20% of the equipment, this was inferior to 2,5 mm Al. The test of the luminance of view box shown that 96% of the equipment, shown a luminance lower of 2.000 cd/m{sup 2}. Related to the test of the uniformity of the luminance, 81 % of the equipment shown a variation of the uniformity higher then 10%. The test of the iluminancy of the environment shown that 61 % of the equipment presented on iluminancy level out of the gap between 50 and 100 lux. The results of this survey showed that a high percentage of the equipment surveyed demonstrated inadequate operating conditions, reinforcing the need to implement quality control protocols in conventional x-ray units located in Recife. (author)

  7. Evaluation of the ionizing radiation effects of the {sup 60}Co on the physical, chemical and nutritional properties of Phaseolus vulgaris L. e Vigna unguiculata (L.) Walp beans; Avaliacao dos efeitos da radiacao ionizante de {sup 60}Co em propriedades fisicas, quimicas e nutricionais dos feijoes Phaseolus vulgaris L. e Vigna unguiculata (L.) Walp

    Energy Technology Data Exchange (ETDEWEB)

    Villavicencio, Anna Lucia Casanas Haasis

    1998-07-01

    The effects of {sup 60} Co ionizing radiations in doses of 0; 0.5; 1.5; 2.5; 5.0 and 10 kGy on beans, Phaseolus vulgaris L., of the carioca variety and Vigna unguiculata (L.) Walp, of the macacar variety stored for 6 months were studied. The cooking time was established, and then the following analyses were carried out: Sensory, vitamins B{sub 1}, B{sub 2} and B{sub 6} protein content, biological evaluation in rats (Food intake and Weight gain (in grams)), apparent Digestibility (Dapp), apparent Net Protein Utilization (NPUapp) and apparent Biological Value (BVapp), as well as the applicability of detection methods of irradiated foodstuffs through germination tests, the analysis of DNA migration, thermoluminescence and analysis of the carbohydrates formed by radiation. Changes in the cooking time were observed for all doses. In doses up to 1 kGy, the nutritional quality of the irradiated beans were not altered. The application of the proposed detection methods of the irradiated foodstuffs allowed the detection of irradiated beans with doses as low as 0.5 kGy. (author)

  8. Dos escuelas en Daly City (California

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    Ciampi, Mario J.

    1965-10-01

    Full Text Available The «Vista Grande» School includes a kindergarten, children's school, six school rooms for various levels of secondary instruction, and other facilities. The «Fernando Rivera» School has 12 schoolrooms, a children's classroom, a library, administrative offices, and a zone for a variety of other uses. Both buildings have been well designed. Space and light, the contrasts of volumes, and the power of colouring have been successfully handled.La Escuela «Vista Grande» se compone de: jardín de la infancia, clase para párvulos, seis aulas para los distintos grados, una zona para la administración, dependencias auxiliares, etc. La Escuela «Fernando Rivera» consta de: doce aulas, una clase para párvulos, biblioteca, dependencias para la administración, una zona para múltiples usos, etc. En los dos edificios, el espacio y la luz, la dinámica de la forma y la energía del color han sido acertadamente empleados.

  9. Dos celebraciones religiosas en un mundo globalizado

    Directory of Open Access Journals (Sweden)

    María Iracheta

    2009-01-01

    Full Text Available Este artículo intenta responder a la pregunta ¿cómo permanecen dos fiestas religiosas mexicanas -la de la Nuestra Señora de Tonatico, en su Santuario, ubicado en el municipio de Tonatico, Estado de México y la de la Virgen del Rosario en su iglesia del Barrio de Xochimilco, -en la ciudad de Oaxaca, capital del Estado de Oaxaca, -en el contexto de la modernización y la globalización? Tres elementos ayudan a explicar esta permanencia: la tradición, que es asumida y reproducida por el "linaje de creyentes" pasados, presentes y futuros; el ritual, que reproduce la memoria histórica y la identidad local; y la apropiación de elementos culturales ajenos a la cultura local para sobrevivir en contextos globales. Estas celebraciones permiten restituir la armonía en los pueblos o barrios, que han cambiado drásticamente por la inserción de los mismos en un mercado mundial. También generan la percepción de tener el control de la comunidad frente a los grandes procesos externos que la amenazan: la mancha urbana, el comercio internacional, los medios masivos de comunicación, la cultura de masas, entre otros.

  10. Epigenetic changes in tumor microenvironment

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    P Dey

    2011-01-01

    Full Text Available The drama of cancer is not the solo performance of the malignant cells. Microenvironment of the tumor has significant contribution in carcinogenesis. Recent evidences show distinct gene promoter methylation in stromal cells of various malignant and pre-malignant tumors. These changes probably create unique tumor microenvironment, which is responsible for initiation, proliferation, invasion, and metastasis of tumor cells. In this mini review the role of epigenetic changes of tumor microenvironment in carcinogenesis has been discussed.

  11. Pituitary gland tumors; Hypophysentumoren

    Energy Technology Data Exchange (ETDEWEB)

    Jesser, J.; Schlamp, K.; Bendszus, M. [Radiologische Klinik, Universitaetsklinikum Heidelberg, Abteilung fuer Neuroradiologie, Heidelberg (Germany)

    2014-10-15

    This article gives an overview of the most common tumors of the pituitary gland and the differential diagnostics with special emphasis on radiological diagnostic criteria. A selective search of the literature in PubMed was carried out. Pituitary adenomas constitute 10-15 % of all intracranial tumors and are the most common tumors of the sellar region. Tumors smaller than 1 cm in diameter are called microadenomas while those larger than 1 cm in diameter are called macroadenomas. Approximately 65 % of pituitary gland adenomas secrete hormones whereby approximately 50 % secrete prolactin, 10 % secrete growth hormone (somatotropin) and 6 % secrete corticotropin. Other tumors located in the sella turcica can also cause endocrinological symptoms, such as an oversecretion of pituitary hormone or pituitary insufficiency by impinging on the pituitary gland or its stalk. When tumors spread into the space cranial to the sella turcica, they can impinge on the optic chiasm and cause visual disorders. A common differential diagnosis of a sellar tumor is a craniopharyngeoma. In children up to 10 % of all intracranial tumors are craniopharyngeomas. Other differential diagnoses for sellar tumors are metastases, meningiomas, epidermoids and in rare cases astrocytomas, germinomas or Rathke cleft cysts As these tumors are located in an anatomically complex region of the skull base and are often very small, a highly focused imaging protocol is required. The currently favored modality is magnetic resonance imaging (MRI) with the administration of a contrast agent. The sellar region should be mapped in thin slices. In cases of suspected microadenoma the imaging protocol should also contain a sequence with dynamic contrast administration in order to assess the specific enhancement characteristics of the tumor and the pituitary gland. (orig.) [German] Diese Arbeit ist eine Uebersicht ueber die haeufigsten Hypophysentumoren und deren Differenzialdiagnosen mit Augenmerk auf die

  12. Parotid hybrid tumor

    International Nuclear Information System (INIS)

    Tumors of the salivary glands represent 33%-10% of head and neck neoplasms. The most common location is the parotid gland, accounting for 50%-85% of the cases, with 20%-30% of them being malignant. The following are known to be indicative of a malignant tumor: fast growing, painless mass, associated facial paralysis and lymphadenopathy. Most parotid neoplasm derive from a single histological type but eventually the development of more than one type on the same gland can occur. This paper presents a case of a parotid neoplasm with two different histological tumors, with uncharacteristic clinical presentation. The patient presented initially with ear pain and otorrhoea, in the clinical examination highlighted an external auditory canal tumor. The complementary study revealed a parotid neoplasm and a total resection of the gland was performed. The biopsy revealed an adenoid-cystic carcinoma with differentiated basaloid areas. Adjuvant radio-chemotherapy was administered, and the imaging control with PET-CT showed no evidence of recurrence or dissemination of the tumor

  13. Extradural tumors; Extradurale Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Reith, W.; Yilmaz, U. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany)

    2011-12-15

    Approximately 50-60% of spinal tumors are extradural and depending on the origin and location are classified into tumors of the vertebrae, tumors of the epidural space and primarily extraspinal tumors growing into the spine. Presenting complaints include back pain and weakness as well as myelopathy and radiculopathy due to compression of the spinal cord or the nerve roots, respectively. Imaging of extradural tumors mostly requires both magnetic resonance imaging (MRI) and computed tomography (CT). Extradural masses and infiltration of the cord can be depicted by MRI and CT depicts osteolytic and osteosclerotic lesions and the extent of osseous involvement. Bone scintigraphy is often helpful in detecting metastases and characterizing osteoid osteomas. (orig.) [German] Fuenfzig bis 60% aller spinalen Tumoren sind extradural gelegen. Sie koennen in Knochentumoren (benigne, intermediaere und maligne) und Tumoren des Epiduralraums, und extraspinale Tumoren, die in den Spinalraum vorwachsen, unterteilt werden. Die fuehrenden klinischen Symptome sind Rueckenschmerzen, Schwaeche sowie Myelo- und Radikulopathien, verursacht durch Kompression des Rueckenmarks bzw. der Nervenwurzeln. Die Bildgebung der extraduralen Tumoren erfordert meist sowohl ein MRT als auch eine CT. Das MRT kann die extraduralen Weichteilanteile und Infiltration des Knochenmarks gut darstellen. Veraenderungen im Myelon, z. B. verursacht durch eine Kompression im Sinne einer Myelopathie mit zentromedullaerer Signalanhebung, stellen sich vor allem in den T2-Sequenzen gut dar. Die CT kann osteolytische oder osteosklerotische Laesionen darstellen und das Ausmass der knoechernen Beteiligung aufzeigen. Eine Szintigraphie ist oft hilfreich, um Metastasen nachzuweisen und Osteoidosteome zu charakterisieren. (orig.)

  14. Cryoablation for pulmonary tumor

    International Nuclear Information System (INIS)

    We have experienced more than 200 sessions for mainly metastatic lung tumor and small number of primary lung cancer since 2002. Cryo-probe is inserted percutaneously with local anesthesia under CT scan guide. Co-axial technique is adopted to prevent from hemorrhage and massive air leakage. The average of hospital stay after treatment is 2.6 days. Although pneumothorax was associated with more than half patients, 5% of them experienced chest tube insertion. Local recurrence 1 year after treatment was found 10% of tumors of 10 mm or less diameter, 30% of 11-20 mm diameter, and 40% of 20-30 mm diameter and 100% of 31 mm or more diameter. In case of large vessels (3 mm or more diameter) running within 4 mm from tumor, recurrence rate was higher compared with the same sized tumors without large vessels running nearby. We are eager for the development of 3D-simulation system considering the distribution of caloric value is strongly requested to improve the local control power of cryoablation for lung tumor. (author)

  15. Tumores em animais de produção: aspectos comparativos Tumors in farm animals: comparative aspects

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    Adriano Tony Ramos

    2008-02-01

    Full Text Available Com o objetivo de realizar um estudo retrospectivo de tumores em animais de produção (bovinos, ovinos, eqüinos e suínos, foi realizada uma revisão nos casos suspeitos de neoplasmas recebidos pelo Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas num período de 24 anos (1978-2002. Os aspectos epidemiológicos dos neoplasmas nessas espécies foram relatados, e uma classificação concisa para padronizar a nomenclatura, seguindo padrões internacionais de classificação histológica de tumores, foi realizada. O estudo baseou-se em um universo de 6.267 materiais. Obtiveram-se 175 casos de tumores distribuídos entre as espécies bovina (98/4407, ovina (9/636, eqüina (65/774 e suína (3/450. Esses tumores foram então avaliados e reclassificados. Os dados referentes foram analisados quanto a sua prevalência por raça, sexo, idade e localização anatômica (origem do tumor. Os tumores com maior casuística foram os linfomas nos bovinos, os carcinomas de células escamosas nos bovinos e ovinos e os sarcóides nos eqüinos.Aiming at a complete study on all neoplastic lesions in farm animals (cattle, sheep, horses and swine, a retrospective review was performed covering a 24 years period (1978-2002 at the Regional Diagnostic Laboratory of the Veterinary School in Pelotas, Southern Brazil. The analysis included the review of epidemiological data and the standardization of classification parameters considering current rules of international classification of tumors. Six thousand two hundred and sixty seven samples were analyzed. The distribution among the species was: 98 in cattle, 9 in sheep, 65 in horses and 3 in pigs, over 175 cases detected. Prevalence studies as for the breed, sex, age and anatomical distribution of the tumors were analyzed. Lymphoma in cattle, squamous cell carcinoma in cattle and sheep, and sarcoids in horses were the tumors with higher incidence.

  16. Tumor-associated macrophages: effectors of angiogenesis and tumor progression.

    Science.gov (United States)

    Coffelt, Seth B; Hughes, Russell; Lewis, Claire E

    2009-08-01

    Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population in many tumor types residing in both perivascular and avascular, hypoxic regions of these tissues. Analysis of TAMs in human tumor biopsies has shown that they express a variety of tumor-promoting factors and evidence from transgenic murine tumor models has provided unequivocal evidence for the importance of these cells in driving angiogenesis, lymphangiogenesis, immunosuppression, and metastasis. This review will summarize the mechanisms by which monocytes are recruited into tumors, their myriad, tumor-promoting functions within tumors, and the influence of the tumor microenvironment in driving these activities. We also discuss recent attempts to both target/destroy TAMs and exploit them as delivery vehicles for anti-cancer gene therapy. PMID:19269310

  17. A Importância dos Carboidratos na Alimentação dos Eqüinos

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    Eliane Morgado:

    2008-10-01

    Full Text Available Os carboidratos são extremamente importantes na dieta dos eqüinos,sendo os carboidratos não estruturais as fontes primárias de energia. Os monossacarídeos são as únicas formas de carboidratos que podem ser absorvidos pelo intestino delgado e os carboidratos mais complexos são fermentados no intestino grosso, onde ocorre a fermentação microbiana. As frações dos carboidratos são definidas pelos métodos químicos ou enzimáticos utilizados nas análises, e vários são os métodos de avaliação da qualidade das forragens, e da composição bromatológica dos ingredientes. O sistema de partição dos carboidratos mais adequada à fisiologia digestiva dos eqüinos, seria o fracionamento dos carboidratos não fibrosos em grupo dos Carboidratos hidrolisáveis a açúcar simples no intestino delgado, e grupo dos carboidratos fermentáveis no intestino grosso, produzindo ácidos graxos voláteis.

  18. [Hepatic tumors and radiotherapy].

    Science.gov (United States)

    Rio, E; Mornex, F; Peiffert, D; Huertas, A

    2016-09-01

    Recent technological developments led to develop the concept of focused liver radiation therapy. We must distinguish primary and secondary tumors as the indications are restricted and must be discussed as an alternative to surgical or medical treatments. For hepatocellular carcinoma 5 to 10cm (or more), a conformational radiation with or without intensity modulation is performed. Stereotactic body radiotherapy (SBRT) is being evaluated and is increasingly proposed as an alternative to radiofrequency ablative treatment for primary or secondary tumors (typically less than 5cm). Tumor (and liver) movements induced by respiratory motions must be taken into account. Strict dosimetric criteria must be met with particular attention to the dose-volume histograms to liver and the hollow organs, including cases of SBRT. PMID:27521035

  19. Mediastinal tumors. Update 1995

    International Nuclear Information System (INIS)

    This volume represents the premier work devoted solely to the complex myriad of mediastinal tumors. The contributors to the state-of-the-art text are clinical investigators of international renown. The diagnosis, natural history, and therapeutic strategies in respect of all mediastinal tumors are thoroughly addressed in a concise and logical manner. An emphasis on the multidisciplinary nature of mediastinal tumors is thematic throughout the text. Moreover, the combined-modality treatment schemes that have been increasingly developed worldwide are analyzed. This textbook will prove of value to all general surgeons, thoracic surgeons, medical oncologists, radiation oncologists, pulmonologists, and endocrinologists, as well as to nursing and medical students, residents and fellows-in training. (orig.). 55 figs., 21 tabs

  20. Renal Tumor Biopsy Technique

    Institute of Scientific and Technical Information of China (English)

    Lei Zhang; Xue-Song Li; Li-Qun Zhou

    2016-01-01

    Objective:To review hot issues and future direction of renal tumor biopsy (RTB) technique.Data Sources:The literature concerning or including RTB technique in English was collected from PubMed published from 1990 to 2015.Study Selection:We included all the relevant articles on RTB technique in English,with no limitation of study design.Results:Computed tomography and ultrasound were usually used for guiding RTB with respective advantages.Core biopsy is more preferred over fine needle aspiration because of superior accuracy.A minimum of two good-quality cores for a single renal tumor is generally accepted.The use of coaxial guide is recommended.For biopsy location,sampling different regions including central and peripheral biopsies are recommended.Conclusion:In spite of some limitations,RTB technique is relatively mature to help optimize the treatment of renal tumors.

  1. Granular cell tumor presenting as a tongue nodule: two case reports

    Directory of Open Access Journals (Sweden)

    Sena Costa Nivea

    2012-02-01

    Full Text Available Abstract Introduction Granular cell tumor is an uncommon neoplasm that can occur in any part of the body, including the orofacial region. The tumor is usually benign, but there are reports of cases in which the tumor shows a locally aggressive behavior, malignancy, and distant metastases. The most widely accepted hypothesis is that granular cell tumor arises from the altered metabolism of Schwann cells. The tumor is typically asymptomatic and appears as a nodule that does not exceed 3 cm. Case presentation In case 1, a 26-year-old Caucasian man was seen at the Oral Medicine out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a 'small blister on the tongue', which he had noted approximately three years ago. The nodule was located on the dorsum of the tongue, measured about 1.5 cm in diameter, and was not tender to palpation. Treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of granular cell tumor, which was confirmed by microscopic analysis. In case 2, a 31-year-old Caucasian woman attended the out-patient clinic of the São José dos Campos Dental School, Universidade Estadual Paulista, with a five-year history of a 'painful lump on the tongue'. Intra-oral examination revealed the presence of a nodular lesion measuring approximately 0.8 cm in diameter, which was located deep in the submucosa of the right lateral margin of the tongue. Treatment consisted of an excisional biopsy performed on the basis of the differential diagnosis of neurofibroma and granular cell tumor. Microscopic analysis defined the final diagnosis of granular cell tumor. Conclusions Granular cell tumor is an uncommon tumor that must be carefully diagnosed and treated correctly.

  2. Adult brain tumors

    International Nuclear Information System (INIS)

    Radiotherapy plays an important role in the management of adults with brain tumors. This refresher course will focus on a variety of benign and malignant brain neoplasms and how contemporary radiotherapy affects outcome. Successful outcome after radiotherapy requires that (1) there is no tumor extension beyond the selected target volume, (2) adequate dose is delivered to the target volume, and (3) normal tissue tolerance dose is not exceeded. For many neoplasms serial post-treatment scans may show little change, and success is often measured more by absence of tumor progression than by scan normalization. Three-dimensional treatment planning based on MRI or CT makes it possible to guarantee delivery of the full prescription dose to gross tumor while minimizing the volume of normal tissue receiving high dose. Acceptable dose conformity can often be achieved with 2-4 static beams or arcs, which is usually preferable to opposed lateral fields. Protocols involving substantial dose escalation require a large number of non-coplanar x-ray beams or particle therapy. This course will cover important concepts and techniques which relate to the treatment of brain tumors, including conformal radiotherapy, brachytherapy, radiosurgery, fractionated stereotactic radiotherapy, altered fractionation, inverse treatment planning, re-irradiation, and biologically effective dose (BED). Examples of planning solutions for a variety of tumor types, size and anatomical locations will be given. Note: I will incorporate examples of interesting, difficult and unusual cases from other practices as time permits, provided slides and descriptive materials are sent to me in advance of the course

  3. OS VIDEOJOGOS: AS REPRESENTAÇÕES DOS PAIS SOBRE A PRÁTICA DOS FILHOS

    Directory of Open Access Journals (Sweden)

    Sílvia Coimbra

    2015-04-01

    Full Text Available Os videojogos são um fenómeno com crescimento progressivo desde a década de 70, alojando-se na vida das crianças, dos jovens e até mesmo na dos adultos. Ao passarem muitas horas em frente a um ecrã as crianças podem estar a tornar-se pequenas pessoas inativas, porque as horas que passam a jogar videojogos poderiam ser dedicadas à actividade física, tornando assim as crianças mais ativas e menos sedentárias (Bergamasco et al., 2008. O magnetismo exercido pelos videojogos pode assustar os intervenientes da educação, pois as crianças e jovens de hoje passam horas a jogar, e nesse período de tempo não se consegue saber o que é que as crianças aprendem, ou não aprendem (Pereira, 2007. As investigações nesta área têm abordado esta temática, demonstrando que é importante ter atenção aos conteúdos e número de horas que as crianças dispensam a jogar de forma a poder haver um maior controle desse tempo (Marivoet, 2001; Moita, 2007; Pereira, 2007.Objetivo: Contribuir para o conhecimento e aprofundamento da problemática dos videojogos, relativamente à representação que os pais têm sobre a sua influência no desenvolvimento das crianças, as horas que os seus filhos passam a jogar e ainda se o tempo de jogo furta tempo à actividade física.

  4. The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP: Structure-Function Relationships

    Directory of Open Access Journals (Sweden)

    Toru Shimizu

    2013-06-01

    Full Text Available Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP is a heme-based O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic-di-GMP to linear di-GMP. Cyclic-di-GMP is an important second messenger in bacteria, highlighting the importance of understanding structure-function relationships of Ec DOS. Ec DOS is composed of an N-terminal heme-bound O2-sensing PAS domain and a C-terminal phosphodiesterase catalytic domain. Notably, its activity is markedly enhanced by O2 binding to the heme Fe(II complex in the PAS sensor domain. X-ray crystal structures and spectroscopic and catalytic characterization of the wild-type and mutant proteins have provided important structural and functional clues to understanding the molecular mechanism of intramolecular catalytic regulation by O2 binding. This review summarizes the intriguing findings that have obtained for Ec DOS.

  5. Brain tumors; Hirntumoren

    Energy Technology Data Exchange (ETDEWEB)

    Langen, K.J. [Forschungszentrum Juelich (Germany). Inst. fuer Neurowissenschaften und Biophysik; Stoffels, G. [Duesseldorf Univ. (Germany). C. und O. Vogt Inst. fuer Hirnforschung

    2007-09-15

    Magnetic Resonance Tomography (MRT) is the method of choice for the diagnostics of cerebral gliomas, but the differentiation of tumour tissue from unspecific tissue changes is limited. Positron emission tomography (PET) and Single-Photon-Emission-Computed Tomography (SPECT) may offer relevant additional information which allows for a more accurate diagnostics in unclear situations. Especially, radiolabeled amino acids offer a better delineation of cerebral gliomas which allows an improved guidance of biopsy, planning of surgery and radiation therapy. Furthermore, amino acid imaging appears to be useful to differentiate tumor recurrence from unspecific posttherapeutic tissue, to predict the prognosis especially in low grade gliomas and to monitor the metabolic response during tumor therapy. (orig.)

  6. Radioembolization of hepatic tumors.

    Science.gov (United States)

    Kennedy, Andrew

    2014-06-01

    Unresectable primary and metastatic liver tumors are a leading cause of cancer mortality and morbidity. This remains a challenging and key task for every oncologist despite significant advances that have been made with selective targeted systemic agents and in technology advances with radiotherapy delivery. Radioembolization (RE) is a technique of permanently implanting microspheres containing Yttrium-90 ((90)Y), a beta-emitting isotope with a treatment range of 2 mm, into hepatic tumors. This form of brachytherapy utilizes the unique dual vascular anatomy of the liver to preferentially deliver radioactive particles via the hepatic artery to tumor, sparing normal liver parenchyma. The main treatment inclusion criteria are patients with solid tumors, compensated liver functions, life expectancy of at least three months, and ECOG performance status 0-2. Benefit of RE has been proven in patients that have low-to-moderate extrahepatic disease burden, prior liver radiotherapy, heavy prior chemotherapy and biologic agent exposure, and history of hepatic surgery or ablation. Most of the clinical evidence is reported in metastatic colorectal, and neuroendocrine tumors (NET), and primary hepatocellular cancer. A growing body of data supports the use of RE in hepatic metastatic breast cancer, intrahepatic cholangiocarinoma, and many other metastatic tumor types. Side effects are typically mild constitutional and GI issues limited to the first 7-14 days post treatment, with only 6% grade 3 toxicity reported in large series. Potentially serious or fatal radiation induced liver disease is extremely rare, reported in only 1% or fewer in major series of both metastatic and primary tumors treated with RE. Currently, high priority prospective clinical trials are testing RE combined with chemotherapy in first line therapy for colorectal hepatic metastases, and combined with sorafenib for hepatocellular carcinomas (HCCs). Fortunately, this beneficial and now widely available therapy

  7. Pediatric sinonasal tumors

    International Nuclear Information System (INIS)

    This paper demonstrates the pathology and imaging characteristics of pediatric sinonasal tumors, which are distinctly different from those found in adults. The medical records, radiologic studies, and pathologic findings in 51 patients, aged 18 years or younger, with sinonasal tumors were retrospectively reviewed. CT images and histopathologic correlation were available in all 51 cases, angiography in 17, and MR in 3. The majority of lesions were benign (33/51), with juvenile angiofibroma being the most common (10/33), followed by fibro-osseous lesions (9/33)

  8. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

    OpenAIRE

    Alvear-Sedán Ciro; Barboza-Ubarnes, Miryam; Bonillas-Fierro Miguel [q.e.p.d

    2011-01-01

    CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límite...

  9. Influência dos estilos parentais no desenvolvimento do comportamento criminal dos reclusos

    OpenAIRE

    Silva, Andrea Venícia Santos Reis

    2010-01-01

    A presente investigação procura contribuir para um conhecimento mais aprofundado de uma problemática complexa – os estilos parentais e o desenvolvimento do comportamento criminal. Procura-se compreender em que medida os estilos parentais estão relacionados e influenciam o desenvolvimento do comportamento criminal de reclusos, controlando pelas características sócio-demográficas e antecedentes familiares dos sujeitos. O estudo engloba a população reclusa do Estabelecimento Prisional de C...

  10. avaliação dos riscos para a saúde dos consumidores

    OpenAIRE

    Pereira, Tiago Filipe Garcia

    2014-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas A popularidade das novas substâncias psicoativas, conhecidas como “drogas legais”, está em contínuo crescimento, particularmente entre adolescentes e adultos jovens. Estes produtos são normalmente vendidos via Internet e em lojas designadas por “smart shops”. A internet desempenha um papel importante no estímulo para o ...

  11. Calidad percibida por dos poblaciones adscritas a dos centros de salud de la provincia de Cuenca

    Directory of Open Access Journals (Sweden)

    Retamal González Antonio

    2000-01-01

    Full Text Available FUNDAMENTO: Para prestar un servicio de calidad es fundamental conocer la opinión que sobre la misma tienen los usuarios del mismo. El objetivo del presente trabajo es medir y comparar la calidad percibida por dos poblaciones asignadas a dos centros de salud de la provincia de Cuenca. MÉTODO: Se trata de un estudio descriptivo transversal. Las Zonas Básicas de Salud estudiadas han sido el Centro de Salud de Cardenete y Centro de Salud de Motilla del Palancar, ambos del Área de Salud de Cuenca. Se ha hecho un muestreo aleatorio estratificado por cuotas de edad y sexo a partir de la tarjeta sanitaria individual. Se ha medido la calidad percibida con un cuestionario validado y fiable, utilizado anteriormente con fines similares por el Ministerio de Sanidad y Consumo. RESULTADOS: Se analizan un total de 295 encuestas, 147 a varones y 148 a mujeres. La media de edad es de 48,83 años (DE: 18,77 para el Centro de Salud de Motilla, en Centro de Salud de Cardenete es de 61,93 años (DE: 15,17. La media de frecuencias mensuales de visitas para Centro de Salud de MP ha sido de 1,56 (DE: 1,91; esta media para el Centro de Salud de Cardenete ha sido:2,49 (DE: 4,27. La media de frecuencias semanales para el Centro de Salud de MP ha sido: 0,32 (DE: 0,66; para el Centro de Salud de Cardenete ha sido: 0,49 (DE: 1,03. El tiempo de espera en el Centro de Salud de MP ha sido: 10,86 minutos (DE: 8,27; en el Centro de Salud de Cardenete: 7,88 (DE: 4,55. 83,4 % de los usuarios de los dos Centros de Salud de conocen la posibilidad de libre elección de médico de cabecera. Se han encontrado diferencias estadísticamente significativas en 11 de los 21 ítems estudiados sobre calidad percibida de que consta el cuestionario CONCLUSIÓN. Los resultados de los componentes de la atención según el análisis factorial de los ítems de calidad percibida son coincidentes con los resultados de calidad percibida. De los dos grupos de usuarios estudiados, los que perciben

  12. Dos iglesias de Pierre Pinsard, arquitecto Francia

    Directory of Open Access Journals (Sweden)

    Pinsard, Pierre

    1972-09-01

    Full Text Available Parish Centre of Saint Pierre de Chanel, Bourg-en-Bresse It is located in the modern part of the town, and is built on three levels: — Basement, with public garage. — Ground floor, which has nave with seating capacity for 639, chapel, mortuary, sacristy, presbytery and offices, as well as courtyard, garden, car-park and belfry. — Upper floor, with catechism rooms, gallery, offices and sitting rooms annexed to the presbytery. The basic construction is of expossd concrete with metal columns. Parish Centre of Saint Jean Baptiste de La Salle, Rouen This building is situated on the left bank of the Seine. Consisting of one floor only, it has a main nave with room for 600, a chapel, catechism rooms, two sacristies, mortuary, presbytery, choir and gardens. The construction is of concrete faced with brick, and metal roof with interior wood lining.Centro Parroquial de San Pedro de Chanel, en Bourg-en-Bresse Esta situado en la zona moderna y se ha distribuido en tres plantas: — Sótano: con garaje público. — Planta noble: con nave capaz para 639 plazas, capilla, mortuorio, sacristía, presbiterio y oficinas; además de la plaza, el jardin, aparcamiento y campanil. — Planta alta: con salas de catecismo, tribuna, oficinas y estancias anejas al presbiterio. Construcción fundamental de hormigón visto con pilares metálicos. Centro Parroquial de San Juan Bautista de La Salle, en Ruán Está situado en la orilla izquierda del Sena. Consta de una sola planta, con nave para 600 fieles, capilla, salas de catecismo, dos sacristías, mortuorio, presbiterio, coro y jardines. Construcción a base de hormigón, fábrica de ladrillo a cara vista y cubierta metálica revestida de madera el interior.

  13. NON EPITHELIAL TUMORS OF OVARY

    Directory of Open Access Journals (Sweden)

    Rajani

    2015-05-01

    Full Text Available BACKGROUND: Non epithelial tumors of ovary are uncommon tumors and may generate difficulty in establishing a diagnosis. Small cell carcinoma (SCC of the female genital tract and primary lymphoma of ovary is even rarer, constituting less than 1% of all gynecologic malignancies. These tumors have poor prognosis. In the present study an effort was made to review these tumors in our Institute. AIMS: To know the prevalence, age distribution, clinical presentation and morphological appearance of these tumors. MATERIALS AND METHODS: Analyzed 34 cases of non - epithelial tumors of ovary received in the department of pathology during a period of three years. Specimens were grossed, routinely processed under standardized conditions for paraffin embedding and stained with hematoxylin and eosin using standard procedures. Special stains and Immunohistochemistry was done where ever necessary. RESULTS: A total of ovarian tumors received during this period were 136. Non epithelial tumors of ovary constituted 34/136 (25%, of the ovarian neoplasms. Germ cell tumors constituted 23/34(67.64% followed by sexcord stromal tumors 7/34 (20.58%. Among the rare tumors we encountered a case of small cell carcinoma, primary lymphoma of ovary and 2 cases of Krukenberg tumors of ovary 2/34 (5.88%. CONCLUSION: Small cell carcinoma and primary lymphoma are morphologically similar to sex cord stromal tumors and germ cell tumors, may pose significant problems in establishing the correct diagnosis. Immunohistochemistry is a must to diagnose these lesions as they have grave prognosis.

  14. Resist DoS attacks in UMTS-WLAN

    Science.gov (United States)

    Qu, Huyu; Cheng, Qiang

    2005-06-01

    Wireless network is more vulnerable to denial of service (DoS) attacks than wired one. In this paper we propose two methods to resist DoS attacks in UMTS-WLAN network, one is active and the other is passive. These two are complementary to each other. In active DoS defense method, a mobile terminal generates an authorized anonymous ID (AAI) using its true ID such as IP address, MAC address, PIN code, or asymmetric key, and substitutes its true ID with the authorized anonymous ID. The mobile terminal may be authenticated by the UMTS-WLAN, however its true ID is anonymous to intending attackers. This method can be used to isolate de-authenticating/disassociating DoS attackers, spoofing power-save DoS attacker, etc. In passive DoS defense method, we propose a trace back scheme. We use covert channels in the header of mobile IP packets to trace back the malicious nodes by embedding some address information of intermediate nodes, and recovering the embedded information by the victim. After the victim successfully traces the attacking paths from malicious nodes, it can segregate the malicious nodes and protect itself. This method can be used to resist DoS attacks of mass-produced junk message congestions.

  15. Extradigital Glomus Tumor of Thigh

    Directory of Open Access Journals (Sweden)

    Kemal Beksaç

    2015-01-01

    Full Text Available Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies. They represent around 1–5% of all soft-tissue tumors. High temperature, sensitivity, and pain and localized tenderness are the classical triad of symptoms. Most glomus tumors represent in the subungual area of digits. Extradigital glomus tumors are a very rare entity. There are rare cases of these tumors reported to be in shoulder, elbow, knee, wrist, even stomach, colon, and larynx. We are reporting a case of a glomus tumor on thigh and discuss the histological and immunohistochemical features.

  16. Hyaluronan Promotes Tumor Lymphangiogenesis and Intralymphantic Tumor Growth in Xenografts

    Institute of Scientific and Technical Information of China (English)

    Li-Xia GUO; Ke ZOU; Ji-Hang JU; Hong XIE

    2005-01-01

    Hyaluronan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, has been implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mice, then angiogenesis and lymphangiogenesis of implanted tumors were examined by immunostaining for plateletendothelial cell adhesion molecule-1 and lymphatic vascular endothelial hyaluronan receptor-1 respectively.Interestingly, we found HA promotes tumor lymphangiogenesis and the occurrence of intratumoral lymphatic vessels, but has little effect on tumor angiogenesis. Moreover, HA also promotes intralymphatic tumor growth, although it is not sufficient to potentiate lymphatic metastasis. These results suggest that HA,which is elevated in most malignant tumor stroma, may also play a role in tumor progression by promoting lymphangiogenesis.

  17. Intracardiac tumor causing

    Directory of Open Access Journals (Sweden)

    Christopher P. Jordan

    2016-07-01

    Full Text Available The following report describes the case of newborn girl with an asymptomatic systolic murmur, which on imaging revealed a nearly obstructive mass in the left-ventricular outflow tract. The mass was resected and found to be consistent with a rhabdomyoma. Here, we describe the pathologic and clinical characteristics of this tumor.

  18. Pituitary: Secretory Tumors

    Science.gov (United States)

    ... is caused by the excess secretion of growth hormone (GH). It can cause noticeable changes in your appearance, ... medication approved for acromegaly. Instead of suppressing excess GH production by the pituitary tumor, it works to stop the hormone from acting on the body, but does not ...

  19. Children's Brain Tumor Foundation

    Science.gov (United States)

    ... 3 families will mourn the loss of their child to a brain or spinal cord tumor. Friends, family and community will try to make sense of an untimely death and the unfulfilled promise of a life. 6 families will transition to survivorship. A mother may be too exhausted from providing constant care ...

  20. [Mediastinal tumors: introduction].

    Science.gov (United States)

    Trousse, D; Avaro, J-P

    2010-02-01

    Mediastinal tumors are relatively uncommon, usually incidentally discovered on a chest X-ray in asymptomatic patients. Young adults are particularly concerned. Mediastinal masses represent a group of heterogeneous histological type cell. A definite diagnosis is essential leading to an adequate prompt therapeutic strategy when either benign disease or aggressive malignant tumor is conceivable. Indeed the therapeutic management of such tumors could be strictly medical, requiring exclusive surgical approach or includes a multimodal treatment. Clinical examination and imaging are important tools in the diagnostic approach. However the specific diagnosis could be complex and requires histological confirmation by an experienced pathologist after examination of large biopsies of the tumor. Several investigations, including surgical invasive exploration, should be quickly requested in order to achieve a final diagnosis and refer patients in an adequate therapeutic scheme without delay. The aim of this article is to point out the available diagnostic tools in mediastinal masses, including surgical approach, and to identify the role of surgical resection in specific subtypes. PMID:20207291

  1. Tumor ablations in IMRI

    Institute of Scientific and Technical Information of China (English)

    Roberto Blanco Sequeiros

    2002-01-01

    @@ IntroductionMagnetic resonance imaging based guidance control and monitoring of minimally invasive intervention has developed from a hypothetical concept to a practical possibility. Magnetic-resonance-guided interstitial therapy in principle is defined as a treatment technique for ablating deepseated tumors in the human body.

  2. Upper urinary tract tumors

    DEFF Research Database (Denmark)

    Gandrup, Karen L; Nordling, Jørgen; Balslev, Ingegerd; Thomsen, Henrik S

    2014-01-01

    who underwent nephroureterectomy between 2006 and 2011 and who had split-bolus CTU prior to surgery were included. The images were available electronically. The attenuation values before and after administration of iodine-based contrast media were measured. The radiology, patient, and pathology...... examination is useful to diagnose a tumor in the renal pelvis and the ureter....

  3. Brain tumor stem cells.

    Science.gov (United States)

    Palm, Thomas; Schwamborn, Jens C

    2010-06-01

    Since the end of the 'no-new-neuron' theory, emerging evidence from multiple studies has supported the existence of stem cells in neurogenic areas of the adult brain. Along with this discovery, neural stem cells became candidate cells being at the origin of brain tumors. In fact, it has been demonstrated that molecular mechanisms controlling self-renewal and differentiation are shared between brain tumor stem cells and neural stem cells and that corruption of genes implicated in these pathways can direct tumor growth. In this regard, future anticancer approaches could be inspired by uncovering such redundancies and setting up treatments leading to exhaustion of the cancer stem cell pool. However, deleterious effects on (normal) neural stem cells should be minimized. Such therapeutic models underline the importance to study the cellular mechanisms implicated in fate decisions of neural stem cells and the oncogenic derivation of adult brain cells. In this review, we discuss the putative origins of brain tumor stem cells and their possible implications on future therapies. PMID:20370314

  4. Melhoria da disponibilidade dos equipamentos para o aumento do OEE

    OpenAIRE

    Valente, Filipe Daniel Silva

    2012-01-01

    Este trabalho tem como tema central a eficiência global dos equipamentos (ou Overall Equipment Efficiency - OEE), um indicador que surgiu na metodologia TPM – Total Productive Maintenance. A utilização do OEE permite às empresas analisar as reais condições de utilização dos seus activos, através da identificação das seis grandes perdas dos equipamentos, reflectidas nos índices de disponibilidade, eficiência e qualidade. A multiplicação destes índices resulta no valor do OEE....

  5. Do valor da vida, dos interesses, do sujeito

    OpenAIRE

    Marciano Adilio Spica

    2004-01-01

    O presente artigo versa sobre um dos mais polêmicos temas da ética prática, a saber, a inclusão de seres não-humanos na esfera da moral. Busca-se aqui reconstruir os argumentos de Peter Singer e Holmes Rolston III sobre o valor da vida, dos interesses e do sujeito. Ambos os autores defendem um alargamento da esfera moral, tradicionalmente reduzida somente aos seres da espécie humana. Suas teorias, porém, entram em conflito quando se trata dos limites da esfera moral. Enquanto Singer def...

  6. Atitudes dos residentes face a festivais de música

    OpenAIRE

    Gomes, José Manuel Mano da Silva

    2013-01-01

    O principal objetivo deste projeto de investigação é analisar o apoio dos residentes da cidade de Barcelos face ao evento Milhões de Festa. A satisfação do objetivo referido implicou a realização de uma reflexão teórica, a partir de uma pesquisa bibliográfica focada no conceito de evento, nas perceções e atitudes dos residentes face aos eventos e nos fatores que influenciam a atitude dos residentes face aos eventos. Com base nesta reflexão teórica foi possível desenvolver um...

  7. Aspectos acústicos do comportamento dos golfinhos

    OpenAIRE

    Santos, Manuel Eduardo dos

    1989-01-01

    Este artigo pretende apresentar uma recolha bibliográfica de alguns dados e hipóteses relativos a adaptações sensoriais e comunicativas dos cetáceos, particularmente dos golfinhos. São consideradas as suas capacidades perceptivas e as potencialidades dos canais de comunicação de que dispõem, sendo realçada a sua considerável especialização na utilização do canal acústico. Depois de uma breve referência às suas capacidades auditivas concretas e às teorias explicativa...

  8. Parallel evolution of tumor subclones mimics diversity between tumors

    OpenAIRE

    Martinez, Pierre; Birkbak, Nicolai Juul; Gerlinger, Marco; McGranahan, Nicholas; Burrell, Rebecca; Rowan, Andrew; Joshi, Tejal; Fisher, Rosalie; Larkin, James; Szallasi, Zoltan Imre; Swanton, Charles

    2013-01-01

    Intratumor heterogeneity (ITH) may foster tumor adaptation and compromise the efficacy of personalized medicines approaches. The scale of heterogeneity within a tumor (intratumor heterogeneity) relative to genetic differences between tumors (intertumor heterogeneity) is unknown. To address this, we obtained 48 biopsies from eight stage III and IV clear cell renal cell carcinomas (ccRCC) and used DNA copy-number analyses to compare biopsies from the same tumor with 440 singletumor biopsies fro...

  9. Retroperitoneal calcifying fibrous tumor mimicking an adrenal tumor

    OpenAIRE

    Prochaska, Erica C.; Sciallis, Andrew P.; Miller, Barbra S.

    2016-01-01

    Establishing the etiology of a retroperitoneal tumor may be difficult due to close proximity of multiple organs. Evaluation of retroperitoneal tumors often leads to surgery, many times to obtain a definitive diagnosis and rule out malignancy. Calcifying fibrous tumors (CFT) are very rare soft tissue tumors occurring most often in young patients. They are most often found arising in the thoracic cavity, mediastinum, abdominal cavity and extremities and usually have a benign clinical course. Ma...

  10. Tumor Blood Vessel Dynamics

    Science.gov (United States)

    Munn, Lance

    2009-11-01

    ``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure

  11. Epidemiological features of brain tumors

    Directory of Open Access Journals (Sweden)

    Živković Nenad

    2013-01-01

    Full Text Available Brain tumors account for 1.4% of all cancers and 2.4% of all cancer-related deaths. The incidence of brain tumors varies and it is higher in developed countries of Western Europe, North America, Australia and New Zealand. In Serbia, according to data from 2009, malignant brain tumors account for 2. 2 of all tumors, and from all cancer­related deaths, 3.2% is caused by malignant brain tumors. According to recent statistical reports, an overall incidence of brain tumors for benign and malignant tumors combined is 18.71 per 100,000 persons/year. The most common benign brain tumor in adults is meningioma, which is most present in women, and the most common malignant tumor is glioblastoma, which is most present in adult men. Due to high mortality, especially in patients diagnosed with glioblastoma and significant brain tumor morbidity, there is a constant interest in understanding its etiology in order to possibly prevent tumor occurrence in future and enable more efficient treatment strategies for this fatal brain disease. Despite the continuously growing number of epidemiological studies on possible factors of tumor incidence, the etiology remains unclear. The only established environmental risk factor of gliomas is ionizing radiation exposure. Exposure to radiofrequency electromagnetic fields via cell phone use has gained a lot of attention as a potential risk factor of brain tumor development. However, studies have been inconsistent and inconclusive, so more definite results are still expected.

  12. Intramedullary tumors in children: analysis of 24 operated cases Tumores intramedulares em crianças: análise de 24 casos operados

    Directory of Open Access Journals (Sweden)

    Ricardo de Amoreira Gepp

    2010-06-01

    Full Text Available Intramedullary tumors are rare. The authors reviewed 24 cases operated between 1996 and 2006. The study assessed the clinical characteristics and surgical results based upon the neurological function. METHOD: Medical records of patients with intramedullary astrocytoma and ependymoma were reviewed. The minimal follow up time was 6 months and, at the end of this period, a comparative analysis of the neurological function was performed based using the McCormick scale score. RESULTS: Most patients had astrocytoma (75%. Male gender was more prevalent (58.3%. The most common type of tumor was graded as I or II, and in three cases these were malignant. The total resection of the tumor was achieved in 20.8% of the cases. The statistical analysis did not show a statistically significant difference between preoperative and postoperative grades at McCormick scale. CONCLUSION: The authors concluded that microsurgery to intramedullary tumors did not significantly alter the neurological function after six months.Os tumores intramedulares são doenças raras. Os autores analisaram 24 casos operados entre 1996 e 2006. O estudo analisou as características clínicas e o resultado da cirurgia quanto à função neurológica. MÉTODO: Foram analisados pacientes com astrocitomas e ependimomas intramedulares. O tempo mínimo de acompanhamento foi de 6 meses e ao final deste período foi realizada a avaliação comparativa da variação do estado neurológico baseado na escala de McCormick. RESULTADOS: A maioria dos pacientes era de astrocitoma (75%. O gênero masculino foi mais prevalente (58,3%. A maioria dos tumores era de grau I ou II, 3 casos eram malignos. A ressecção total do tumor ocorreu em 20,8% dos casos. A avaliação estatística demonstrou que não houve diferença significativa entre o estado neurológico na escala de McCormick pré-operatória e pós-operatória. CONCLUSÕES: Os autores concluem que a microcirurgia para ressecção dos tumores

  13. Tumor estromal gastrointestinal: análise de fatores relacionados ao prognóstico Gastrointesinal stromal tumor: analysis of factors related to the prognostic

    OpenAIRE

    Rodrigo Panno Basilio de Oliveira; Vera Lucia Pannain; Pedro Eder Portari Filho; Alemar Roge Salomão; Antonio Carlos Iglesias; Carlos Alberto Basilio de Oliveira

    2007-01-01

    OBJETIVO: estudar os critérios morfológicos e imunoistoquímicos relacionados ao prognóstico dos tumores estromais gastrointestinais. MÉTODOS: o estudo foi retrospectivo de 42 casos de tumor estromal gastrointestinal (GIST). Vinte e cinco casos foram obtidos no arquivo do Serviço de Anatomia Patológica do Hospital Universitário Gaffrée e Guinle e os outros dezessete, do Serviço de Anatomia Patológica do Hospital Universitário Clementino Fraga Filho. RESULTADOS: de acordo com a análise univaria...

  14. Síndrome dos nervos cranianos por glioma do tronco cerebral: Estudo anátomo-clínico de um caso

    Directory of Open Access Journals (Sweden)

    J. Lamartine de Assis

    1945-03-01

    Full Text Available Trata-se de um caso de glioma (astrocitoma fibrilar do segmento hemibulbo-protuberancial esquerdo, e cujo quadro clínico foi dos mais polimorfos, dada a topografia e extensão do tumor. As diversas síndromes clínicas permitiram estabelecer o diagnóstico topográfico, o qual foi totalmente comprovado pela demonstração anátomo-patológica.

  15. Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina; Avaliacao dosimetrica de uma combinacao de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porcao distal da vagina

    Energy Technology Data Exchange (ETDEWEB)

    Guimaraes, Roger Guilherme Rodrigues [Real e Benemerita Sociedade Portuguesa de Beneficencia, Sao Paulo, SP (Brazil). Servico de Radioterapia Estereotactica; Carvalho, Heloisa de Andrade; Stuart, Silvia Radwanski; Rubo, Rodrigo Augusto [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radioterapia], e-mail: handrade@hcnet.usp.br; Seraide, Rodrigo Migotto [Centro de Oncologia Campinas, SP (Brazil)

    2009-07-15

    Objective: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. Materials And Methods: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. Results: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). Conclusion: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina. (author)

  16. Postoperative concurrent radio-chemotherapy for locally advanced head and neck cancer;Avaliacao de radio e quimioterapia concomitantes pos-operatorias nos pacientes portadores de tumores de cabeca e pescoco localmente avancados

    Energy Technology Data Exchange (ETDEWEB)

    Fortuna, Ana Paula Diniz; Carvalho, Ravenna Nogueira; Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo, E-mail: segreto.dmed@epm.b [Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP (Brazil). Dept. de Oncologia Clinica e Experimental. Setor de Radioterapia

    2009-12-15

    To evaluate the clinical outcome of patients with locally advanced head and neck cancer treated with postoperative concurrent radio-chemotherapy. Material and method: thirty nine patients with locally advanced head and neck cancer submitted to resection of all visible and palpable disease, followed by radiotherapy (60-66 Gy in 30 to 33 fractions over a period of 6 to 6.6 weeks) and concurrent cisplatin between May 2004 and June 2007 were retrospectively analyzed. Results: a predominance of male with a median age of 54 years was observed; 30.8% of patients were in stage III and 61.5% in stage IVA; 77% of patients received a radiation dose of 66 Gy; dermatitis grade III occurred in 46.2% and fibrosis in 48.7% of patients. The 5-year loco-regional failure and overall survival were 30% and 76%, respectively. Conclusion: data show that surgery followed by concurrent radio-chemotherapy presents reasonable rate of loco-regional control and disease-free survival in high-risk patients. Our index of loco-regional and distant failure and the rate of acute and late complication are compatible with other series in the literature (author)

  17. What Are Lung Carcinoid Tumors?

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » What are lung carcinoid tumors? Share this Page Close Push escape to close share window. Print ...

  18. Drugs Approved for Brain Tumors

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Brain Tumors This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Brain Tumors Afinitor (Everolimus) Afinitor Disperz (Everolimus) Avastin (Bevacizumab) Becenum ( ...

  19. How Are Wilms Tumors Diagnosed?

    Science.gov (United States)

    ... at under a microscope. The cells in Wilms tumors have a distinct appearance when looked at this way. Doctors also look at the sample to determine the histology of the Wilms tumor (favorable or unfavorable), as was described in the ...

  20. Neuroendocrine tumors of the pancreas.

    LENUS (Irish Health Repository)

    Davies, Karen

    2012-02-01

    Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies. They are broadly classified into either functioning tumors (insulinomas, gastrinomas, glucagonomas, VIPomas, and somatostatinomas) or nonfunctioning tumors. The diagnosis of these tumors is difficult and requires a careful history and examination combined with laboratory tests and radiologic imaging. Signs and symptoms are usually related to hormone hypersecretion in the case of functioning tumors and to tumor size or metastases with nonfunctioning tumors. Surgical resection remains the treatment of choice even in the face of metastatic disease. Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.

  1. Neuroendocrine tumors of the pancreas.

    LENUS (Irish Health Repository)

    Davies, Karen

    2009-04-01

    Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies. They are broadly classified into either functioning tumors (insulinomas, gastrinomas, glucagonomas, VIPomas, and somatostatinomas) or nonfunctioning tumors. The diagnosis of these tumors is difficult and requires a careful history and examination combined with laboratory tests and radiologic imaging. Signs and symptoms are usually related to hormone hypersecretion in the case of functioning tumors and to tumor size or metastases with nonfunctioning tumors. Surgical resection remains the treatment of choice even in the face of metastatic disease. Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.

  2. Neurogenic tumors of the stomach

    International Nuclear Information System (INIS)

    The general and radiologic features of neurogenic tumors of the stomach are reviewed in connection with 18 cases (16 benign and 2 maglignant tumors). Such neurogenic tumors are rare in the stomach, representing less than 0.5% of all tumors. Solitary neurogenic tumors must be differentiated from those encountered during von Recklinghausen's disease. Radiological or endoscopic examination can generally determine the benign or malignant nature of solitary neurogenic tumors, which are essentially represented by schwannomas. Since these tumors are submucosal, a deep biopsy is imperative; furthermore, since such tumors are subject to hemorrhage, prior investigation by CT appears advisable to detect possible hypervascularization after injection of contrast material. For patients with von Recklinghausen's disease, a neurofibroma is usually diagnosed when faced with a digestive hemorrhage. Radiological exploration of the entire digestive tract appears essential to confirm the solitary nature of the gastric lesion and to be sure it is responsible for the clinical symptoms. (orig.)

  3. Sobriedade e embriaguez: a luta dos soldados de Cristo contra as festas dos tupinambás

    Directory of Open Access Journals (Sweden)

    João Azevedo Fernandes

    2007-01-01

    Full Text Available O artigo analisa a luta dos missionários cristãos, em especial os jesuítas, contra as festas e as bebidas alcoólicas dos tupinambás. Eles perceberam que, nestas festas, a cultura tupinambá, principal obstáculo à evangelização, se renovava e se reafirmava constantemente. O artigo também explora as principais estratégias usadas pelos europeus para alcançar o objetivo de extinguir as festas dos índios.

  4. Biopsy in Musculoskeletal Tumors

    Directory of Open Access Journals (Sweden)

    Mohammad Gharehdaghi

    2014-09-01

    Full Text Available Diagnosis of bone tumors is based on careful evaluation of clinical, imaging and a pathologic findings. So the biopsy of bone and soft tissue sarcomas is the final step in evaluation and a fundamental step in the diagnosis of the lesion. It should not be performed as a shortcut to diagnosis (1. The biopsy should be performed in order to confirm the diagnosis and differentiate among few diagnoses after careful staged studies. Real and artificial changes in imaging studies will be superimposed after performing biopsy, which may alter the interpretation if done after biopsy is taken (1. The correct management of a sarcoma depends on the accurate diagnosis. Inadequate, inapprppriate, or inaccurate non-representative biopsy leads to poorer outcome in terms of survivorship and limb salvage. An incorrect, unplanned incision and biopsy may unnecessarily contaminate uninvolved compartments which may convert a salvageable limb to amputation. Anatomic approach along with the proper biopsy techniques may lead to success or catastrophe. It is clear that in patients with inappropriate biopsy, the chance of the need to change the treatment to more radical than would originally be expected is significantly higher. Also it is more probable to need to  convert curative to palliative treatment and to require adjuvant radiotherapy in patients with inappropriate biopsies. Patients with sarcoma are best served by early referral to a specialized center where staged investigations and biopsy can be performed with minimal morbidity (3. Open biopsy is still considered the gold standard; however, recent studies suggest comparable results with percutaneous core needle biopsy. Our study on 103 consecutive CNB and open biopsy showed comparable results as well. Surgeons need to answer to two questions prior to performing a biopsy: 1-          Where is the best part of the lesion to be biopsied? 2-          What is the safest route without contaminating

  5. Abordagens cirúrgicas para os osteomas dos seios paranasais Surgical approaches to the paranasal sinuses osteoma

    OpenAIRE

    Fernando O. Balieiro; André Bordash; Aldo E. C. Stamm; Bruno B. Sebusiani; Iulo S. Baraúna Filho

    2004-01-01

    Os osteomas são os tumores benignos mais freqüentes dos seios paranasais, apresentam crescimento lento e são em sua maioria assintomáticos. O tratamento cirúrgico destes tumores, ainda, é um tema controverso no que tange suas indicações e a escolha da abordagem cirúrgica. Existem diversas opções cirúrgicas que vão desde as abordagens externas clássicas até as transnasais assistidas por vídeo-endoscopia. Não existem indicações formais para cada uma das abordagens devendo-se sempre levar em con...

  6. Growth factors in tumor microenvironment

    OpenAIRE

    Zhang, Xuejing; Nie, Daotai; Chakrabarty, Subhas

    2010-01-01

    Tumor microenvironment plays a critical role in tumor initiation and progression. Components in the microenvironment can modulate the growth of tumor cells, their ability to progress and metastasize. A major venue of communication between tumor cells and their microenvironment is through polypeptide growth factors and receptors for these growth factors. This article discusses three major classes of growth-stimulatory polypeptide growth factors and receptors for these growth factors. It also d...

  7. Tumor suppressor and hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Juliette Martin; Jean-Frangois Dufour

    2008-01-01

    A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

  8. Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control

    International Nuclear Information System (INIS)

    Background and purpose: The causes of tumor response variation to radiation remain obscure, thus hampering the development of predictive assays and strategies to decrease resistance. The present study evaluates the impact of host tumor stromal elements and the in vivo environment on tumor cell kill, and relationship between tumor cell radiosensitivity and the tumor control dose. Material and methods: Five endpoints were evaluated and compared in a radiosensitive DNA double-strand break repair-defective (DNA-PKcs−/−) tumor line, and its DNA-PKcs repair competent transfected counterpart. In vitro colony formation assays were performed on in vitro cultured cells, on cells obtained directly from tumors, and on cells irradiated in situ. Permanent local control was assessed by the TCD50 assay. Vascular effects were evaluated by functional vascular density assays. Results: The fraction of repair competent and repair deficient tumor cells surviving radiation did not substantially differ whether irradiated in vitro, i.e., in the absence of host stromal elements and factors, from the fraction of cells killed following in vivo irradiation. Additionally, the altered tumor cell sensitivity resulted in a proportional change in the dose required to achieve permanent local control. The estimated number of tumor cells per tumor, their cloning efficiency and radiosensitivity, all assessed by in vitro assays, were used to predict successfully, the measured tumor control doses. Conclusion: The number of clonogens per tumor and their radiosensitivity govern the permanent local control dose

  9. Tumor Budding in Colorectal Carcinomas

    Directory of Open Access Journals (Sweden)

    Sevda SERT BEKTAŞ

    2012-01-01

    Full Text Available Objective: In colorectal carcinomas, tumor budding has been defined as the presence of isolated single tumor cells or small cell clusters in the stroma at the invasive tumor margin. In this study, the relationship between tumor budding density at the invasive tumor margin and pathological parameters is investigated.Material and Method: Haematoxylin and eosin stained slides of 73 cases with colorectal carcinoma were retrospectively evaluated for the presence and intensity of tumor budding by 2 observers. After the specimens were assessed, the highest density of tumor budding area was counted in a microscopic field of x200. Cases were separated into 2 groups according to tumor budding density as low grade (<10 and high grade (≥10. The relationship of these groups with depth of tumor invasion, histological grade, vascular invasion and lymph node involvement was investigated.Results: Of the 73 colorectal carcinoma cases, 33 (45.2% had low and 40 (54.8% had high grade tumor budding density, respectively. There was a statistically significant relationship between high grade tumor budding density and histological grade (p=0.042, lymph node involvement (p=0.0001 and vascular invasion (p=0.0034.Conclusion: High grade tumor budding density is associated with aggressive phenotypical features in colorectal carcinoma.

  10. Apoptosis in irradiated murine tumors.

    Science.gov (United States)

    Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E

    1991-09-01

    Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors. PMID:1886987

  11. Tumor Microenvironment in the Brain

    International Nuclear Information System (INIS)

    In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context

  12. Tumor Microenvironment in the Brain

    Energy Technology Data Exchange (ETDEWEB)

    Lorger, Mihaela [Leeds Institute of Molecular Medicine, University of Leeds, St. James’s University Hospital, Beckett Street, Leeds, LS9 7TF (United Kingdom)

    2012-02-22

    In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.

  13. Notch Signaling and Brain Tumors

    DEFF Research Database (Denmark)

    Stockhausen, Marie; Kristoffersen, Karina; Poulsen, Hans Skovgaard

    2011-01-01

    Human brain tumors are a heterogenous group of neoplasms occurring inside the cranium and the central spinal cord. In adults and children, astrocytic glioma and medulloblastoma are the most common subtypes of primary brain tumors. These tumor types are thought to arise from cells in which Notch...

  14. OptaDOS - a new tool for EELS calculations

    International Nuclear Information System (INIS)

    Many modern (Scanning) Transmission Electron Microscopes ((S)TEMs) are equipped with an energy loss spectrometer. The Electron Energy Loss (EEL) spectra collected provide an experimental method of probing the bonding within a material. With the extra addition of monochromators, the energy resolution obtainable means that even more information is revealed within the fine structure of the spectra. Interpreting the fine structure can often be aided by simulation. Density-functional theory (DFT) is one method of simulating EEL spectra. DFT allows us to simulate DOS and EEL spectra from different structures. This comparison between simulation and experiment enables us to explore how changes in the spectrum are related to changes within the sample. CASTEP is a pseudopotential DFT code which can simulate both low-loss and core-loss EEL spectra. Recent developments have resulted in a separate analysis tool, OptaDOS. This package computes various spectral properties including DOS, projected DOS, joint DOS, core-loss and low-loss EEL spectra and optical spectra. One of the important aspects of the code is the way in which the DOS is calculated. This is done via linear extrapolation or adaptive smearing, methods which are not currently available within CASTEP (or indeed any other code) and which allow detailed analysis of spectral properties. This paper summarises these developments and what they mean for the interpretation of EEL spectra.

  15. CT findings of parotid gland tumors: benign versus malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Moon Ok; Han, Chun Hwan; Kim, Mie Young; Yi, Jeong Geun; Park, Kyung Joo; Lee, Joo Hyuk [Kang Nam General Hospital, Public Corporation, Seoul (Korea, Republic of); Bae, Sang Hoon [Hallym University College of Medicine, Seoul (Korea, Republic of); Kim, Jeung Sook [Korea Veterans Hospital, Seoul (Korea, Republic of)

    1994-03-15

    The purpose of this study is to evaluate the characteristics of parotid gland tumors to help in the differentiation between benign and malignant lesions. The CT findings of 22 patients with surgically proven parotid gland tumors were reviewed. Analysis was focused on the density and margin characteristics of the tumors, and the relationship between the tumor and surrounding structures. Those tumors were pleomorphic adenoma (n = 8), Warthin's tumor (n = 5), basal cell adenoma (n = 1), lipoma (n = 1), dermoid cyst (n = 1), adenoid cystic carcinoma (n = 2), mucoepidermoid carcinoma (n 1), epidermoid carcinoma (n = 1), and carcinoma in pleomorphic adenoma (n 1). Most of benign and malignant tumors were heterogeneous in density on contrast enhanced CT scans. In 5 of 6 malignant cases, the tumors had irregular or ill-defined margin and a tendancy to involve or cross the superficial layer of deep cervical fascia with obliteration of subcutaneous fat. Two malignant tumors invaded surrounding structures. Although the heterogeneous density of tumor is not a specific finding for malignancy at CT, following findings, such as, irregular or blurred margin of the lesion, the involvement of fascial plane, and the infiltration of surrounding structures may suggest the possibility of malignant parotid tumor.

  16. CT findings of parotid gland tumors: benign versus malignant tumors

    International Nuclear Information System (INIS)

    The purpose of this study is to evaluate the characteristics of parotid gland tumors to help in the differentiation between benign and malignant lesions. The CT findings of 22 patients with surgically proven parotid gland tumors were reviewed. Analysis was focused on the density and margin characteristics of the tumors, and the relationship between the tumor and surrounding structures. Those tumors were pleomorphic adenoma (n = 8), Warthin's tumor (n = 5), basal cell adenoma (n = 1), lipoma (n = 1), dermoid cyst (n = 1), adenoid cystic carcinoma (n = 2), mucoepidermoid carcinoma (n 1), epidermoid carcinoma (n = 1), and carcinoma in pleomorphic adenoma (n 1). Most of benign and malignant tumors were heterogeneous in density on contrast enhanced CT scans. In 5 of 6 malignant cases, the tumors had irregular or ill-defined margin and a tendancy to involve or cross the superficial layer of deep cervical fascia with obliteration of subcutaneous fat. Two malignant tumors invaded surrounding structures. Although the heterogeneous density of tumor is not a specific finding for malignancy at CT, following findings, such as, irregular or blurred margin of the lesion, the involvement of fascial plane, and the infiltration of surrounding structures may suggest the possibility of malignant parotid tumor

  17. Tumor-Induced Hyperlipidemia Contributes to Tumor Growth

    Directory of Open Access Journals (Sweden)

    Jianfeng Huang

    2016-04-01

    Full Text Available The known link between obesity and cancer suggests an important interaction between the host lipid metabolism and tumorigenesis. Here, we used a syngeneic tumor graft model to demonstrate that tumor development influences the host lipid metabolism. BCR-Abl-transformed precursor B cell tumors induced hyperlipidemia by stimulating very low-density lipoprotein (VLDL production and blunting VLDL and low-density lipoprotein (LDL turnover. To assess whether tumor progression was dependent on tumor-induced hyperlipidemia, we utilized the VLDL production-deficient mouse model, carboxylesterase3/triacylglycerol hydrolase (Ces3/TGH knockout mice. In Ces3/Tgh−/− tumor-bearing mice, plasma triglyceride and cholesterol levels were attenuated. Importantly tumor weight was reduced in Ces3/Tgh−/− mice. Mechanistically, reduced tumor growth in Ces3/Tgh−/− mice was attributed to reversal of tumor-induced PCSK9-mediated degradation of hepatic LDLR and decrease of LDL turnover. Our data demonstrate that tumor-induced hyperlipidemia encompasses a feed-forward loop that reprograms hepatic lipoprotein homeostasis in part by providing LDL cholesterol to support tumor growth.

  18. CARTOGRAFIA DOS IMPACTOS AMBIENTAIS NO PARQUE NACIONAL DA CHAPADA DOS VEADEIROS (GO

    Directory of Open Access Journals (Sweden)

    Carlos Shiley Domiciano

    2012-01-01

    Full Text Available The main objective of this study is to show, through cartographic studies, the environmental impacts of the tourism at Chapada dos Veadeiros National Park in São Jorge District, Alto Paraíso City-Goiás and outskirts. Also to verify the tourists perception, the public functionaries perception and local community perception of this impacts. The André Journaux methology of synthesis maps was used for to elaborate one Landscape Unity Map, where the environmental impacts was registered. The autors observed the impacts and interviewed tourists, residents, local administrators and national park administrators. Was evidenced that impacts mark the local landscape, reflecting the social practices of the place.

  19. MR findings of ovarian tumors with hormonal activity, with emphasis on tumors other than sex cord-stromal tumors

    International Nuclear Information System (INIS)

    Sex cord-stromal tumors including granulosa cell tumor, thecoma, Sertoli stromal cell tumor and steroid cell tumor are noted for their hormonal activity. However, there are many kinds of ovarian tumors other than sex cord-stromal tumors and tumor-like conditions with endocrine manifestations. Cross-sectional imaging, especially MR, can provide precise features of ovarian tumors and uterine morphological change even in a clinically latent excess of estrogen. In this article, we demonstrate typical imaging findings of ovarian tumors with hormonal activity. We also shortly explain the mechanism of the virilization and hyperestrogenism caused by ovarian tumors and tumor-like conditions

  20. Large-sized kidney tumor mimicking an extraorgan retroperitoneal tumor

    Directory of Open Access Journals (Sweden)

    I. A. Reva

    2015-03-01

    Full Text Available The retroperitoneal space may be a site for a broad spectrum of both rare benign and malignant tumors that are in turn a focus of primary or metastatic involvement. Sarcomas, lymphomas, and different epithelial tumors (of the kidney, adrenal, and pancreas constitute the bulk of retroperitoneal tumors. Detection of a large-sized tumor located at one of the renal poles may raise the question of whether this mass is a kidney tumor or an extraorgan retroperitoneal tumor adjacent to or growing into the kidney. In view of significant differences in treatment procedures for various retroperitoneal tumors, when the origin of the mass is unknown, there is a need for an individual approach to defining the optimal therapeutic and diagnostic tactics, by attracting specialists in allied fields. 

  1. Inflammatory myofibroblastic tumor

    Directory of Open Access Journals (Sweden)

    Sangeeta Palaskar

    2011-01-01

    Full Text Available Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. A number of terms have been applied to the lesion, namely, inflammatory pseudotumor, fibrous xanthoma, plasma cell granuloma, pseudosarcoma, lymphoid hamartoma, myxoid hamartoma, inflammatory myofibrohistiocytic proliferation, benign myofibroblatoma, and most recently, inflammatory myofibroblastic tumor. The diverse nomenclature is mostly descriptive and reflects the uncertainty regarding true biologic nature of these lesions. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. We hereby report a case of inflammatory pseudotumor and review its inflammatory versus neoplastic behavior.

  2. Adenomatoid odontogenic tumor

    International Nuclear Information System (INIS)

    A 18-year-old man had a painless swelling in the right anterior portion of maxilla for 2 years. On radiographic examination, a radiolucent region that was not associated with an unerupted tooth was seen. Small scattered radiopaque foci were seen in the cystic lumen. At second case, a 16-year-old girl had a painless swelling in the anterior portion of maxilla for 3 years. On radio graphic examination, a radiolucent region that associated with an unerupted tooth was seen. Multiple scattered radiopaque foci were seen in the radiolucent cystic lumen. With the patient under local anesthesia, well encapsulated tumors were enucleated. The diagnosis made in the pathologist's report was Adenomatoid Odontogenic Tumor, benign lesion often having distinct clinical and radiographic features.

  3. Ganglioglioma: comparison with other low-grade brain tumors Ganglioglioma: estudo comparativo com outros tumores cerebrais primarios de baixo grau

    Directory of Open Access Journals (Sweden)

    Paulo Thadeu Brainer-Lima

    2006-09-01

    Full Text Available METHOD: Forty-two patients with low-grade brain tumor and refractory epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19 and group B, patients with other low-grade tumors (n=23 (14 astrocytoma, 6 oligodendroglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastrocytoma. RESULTS: Age at seizure’s onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045. Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively. Seizure’s frequency was higher in group B (p=0.002.Computerized tomography (CT was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI was abnormal in all patients. Surgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in group B. CONCLUSION: The association of refractory epilepsy and complex partial seizures, at a relatively low frequency, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.MÉTODO: Foram estudados 42 pacientes com tumor cerebral primário de baixo grau e epilepsia refratária. A idade média foi 22,3 anos. Eles foram divididos em dois grupos: no grupo A os pacientes com ganglioglioma (n=19 e no grupo B os pacientes com outros tumores primários de crescimento lento (n=23 (14 astrocitomas, 6 oligodendrogliomas, 2 tumores desembrioblástico neuroepitelial e um xantoastrocitoma. RESULTADOS: A idade de início das crises convulsivas foi 7 anos ou menos em 73% dos pacientes no grupo A e 30,4% dos pacientes no grupo B (p=0,045. A crise convulsiva do tipo parcial complexa foi a mais identificada nos grupos A e B (94,7% versus 82%, respectivamente. A freqüência de crise foi mais alta no grupo B (p=0,002. A tomografia computadorizada

  4. ADENOMATOIDNI TUMOR JAJOVODA

    OpenAIRE

    Labinac-Peteh, Loredana; Matković-Bilin, Marija; Pirkić, Ahmed; Končar, Milan; Kučinar, Ilija

    2006-01-01

    A 51-year-old woman, nulipara, was admitted to the Department of Gynecology and Obstetrics, University Hospital “Sestre Milosrdnice“, Zagreb, Croatia, because of a single cyst on the left ovary. Hysterectomy with bilateral salpingoophorectomy was performed. The left tube contained a well circumscribed, round, yellowish nodule of middle firm consistency, which was situated both under the serosa and in the muscular layer. The tubal lumen was strongly displaced by the tumor. Histologically, the ...

  5. Respiratory tract tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008053 Expression of PTEN gene in non-small cell lung cancer. HONG Zheng(洪征),et al. Dept Thoracic Surg, Thoracic Tumor & Tuberc Res Instit , Beijing 101149. Chin J Clin Oncol Rehabil 2007;14(6):487-490. Objective To investigate the expression of PTEN gene in non-small cell lung cancer (NSCLC) and analyze the role of PTEN gene in lung tumorigenesis. Methods Immunohistochemical stain was used to determine the expression of PTEN in

  6. Combined tumor therapy

    International Nuclear Information System (INIS)

    This comprehensive survey of current methods and achievements first takes a look at the two basic therapies, devoting a chapter each to the surgery and radiotherapy of tumors. The principal subjects of the book, however, are the systemic, adjuvant therapy, biological therapies, hyperthermia and various other therapies (as e.g. treatment with ozone, oxygen, or homeopathic means), and psychotherapy. (MG) With 54 figs., 86 tabs

  7. Intracranial germ cell tumor

    OpenAIRE

    Kreutz, J; Rausin, L.; Weerts, E; Tebache, M; Born, J; Hoyoux, C

    2010-01-01

    Germ cell tumours represent about 3 to 8% of pediatric brain tumours. Occurrence of diabetes insipidus is common in the case of suprasellar germ cell tumors. The diagnosis may be advanced by MRI owing to the location and relatively univocal characteristics of the lesion signal. The existence of a bifocal mass developed in both suprasellar region and pineal zone is highly suggestive of a germinoma. The most important notion is to recognize that at the time of diabetes insipidus diagnosis in a ...

  8. Familial germ cell tumor

    OpenAIRE

    Sanju Cyriac; Rejeev Rajendranath; A. Robert Louis; Sagar, T. G.

    2012-01-01

    Familial testicular germ cell tumors are well known in literature. Only few cases are reported where both brother and sister of the same family suffered from germ cell malignancies. We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presenc...

  9. Efeitos tardios dos praguicidas organoclorados no homem Delayed effects of organochlorine pesticides in man

    Directory of Open Access Journals (Sweden)

    Mônica Vannucci Nunes

    1998-08-01

    Full Text Available Procurou-se relacionar as informações disponíveis sobre os organoclorados e os efeitos crônicos provocados pela exposição. Os compostos organoclorados são os praguicidas mais persistentes já fabricados. Embora sejam geralmente eficientes no controle das pragas, são importantes poluentes ambientais e potenciais causas de problemas de saúde para o homem, tendo sido proibidos ou controlados na maioria dos países. Com poucas exceções, os efeitos tardios desses compostos sobre a saúde humana são difíceis de detectar, em função de dificuldades metodológicas e da extrapolação dos resultados. A genotoxicidade está entre os mais sérios dos possíveis danos causados por esses compostos e merece atenção especial, devido à natureza irreversível do processo. Outro ponto a ser considerado é o aumento na incidência de alterações no desenvolvimento do trato reprodutivo e na fertilidade masculina observada nas últimas décadas provavelmente decorrente do aumento da exposição intra-uterina a compostos estrogênicos e anti-androgênicos, como os organoclorados.Available information on organochlorines and the chronic effects of exposure to them are set out. Organochlorinated compounds are the most persistent pesticides and can be found in all ecosystems. Although they are generally efficient in pest control, they are also a potent environment pollutant and can provoke health problems in man. The evidences of the carcinogenic potential of organochlorines are controversial and insufficient, but they have been related to an increase in the incidence of some kinds of tumors, such as leukemia and solid tumors. Reproductive effects, due to anti-androgenic and estrogenic action, on embryonic virilization, the incidence of abortion and the frequency of prematurity, have also been observed. The accumulation of the organochlorines in the adipous tissue is positively correlated to the increase in aging and could be implicated in the

  10. A redução dos riscos dos pesticidas pela protecção integrada

    OpenAIRE

    Amaro, Pedro

    2003-01-01

    Os pesticidas de uso agrícola tiveram grande expansão após a 2.ª Guerra Mundial, graças à descoberta e amplo desenvolvimento e aplicação pelos agricultores dos novos pesticidas organossintéticos. A sua fácil aplicação, o apoio eficiente dos técnicos das empresas de pesticidas e, por vezes, dos serviços oficiais e as evidentes vantagens de maior eficácia e de carácter económico justificam a grande expansão do consumo destes pesticidas a partir dos anos 50, 60 e 70. É bem c...

  11. Gastrointestinal stromal tumor

    Directory of Open Access Journals (Sweden)

    Levidou Georgia

    2009-08-01

    Full Text Available Abstract Background GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity and the literature on these stromal tumors has rapidly expanded. Methods An extensive review of the literature was carried out in both online medical journals and through Athens University Medical library. An extensive literature search for papers published up to 2009 was performed, using as key words, GIST, Cajal's cells, treatment, Imatinib, KIT, review of each study were conducted, and data were abstracted. Results GIST has recently been suggested that is originated from the multipotential mesenchymal stem cells. It is estimated that the incidence of GIST is approximately 10-20 per million people, per year. Conclusion The clinical presentation of GIST is variable but the most usual symptoms include the presence of a mass or bleeding. Surgical resection of the local disease is the mainstay therapy. However, therapeutic agents, such as Imatinib have now been approved for the treatment of advanced GISTs and others, such as everolimus, rapamycin, heat shock protein 90 and IGF are in trial stage demonstrate promising results for the management of GISTs.

  12. Mouse Leydig Tumor Cells

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    Bo-Syong Pan

    2011-01-01

    Full Text Available Cordycepin is a natural pure compound extracted from Cordyceps sinensis (CS. We have demonstrated that CS stimulates steroidogenesis in primary mouse Leydig cell and activates apoptosis in MA-10 mouse Leydig tumor cells. It is highly possible that cordycepin is the main component in CS modulating Leydig cell functions. Thus, our aim was to investigate the steroidogenic and apoptotic effects with potential mechanism of cordycepin on MA-10 mouse Leydig tumor cells. Results showed that cordycepin significantly stimulated progesterone production in dose- and time-dependent manners. Adenosine receptor (AR subtype agonists were further used to treat MA-10 cells, showing that A1, A 2A , A 2B , and A3, AR agonists could stimulate progesterone production. However, StAR promoter activity and protein expression remained of no difference among all cordycepin treatments, suggesting that cordycepin might activate AR, but not stimulated StAR protein to regulate MA-10 cell steroidogenesis. Meanwhile, cordycepin could also induce apoptotic cell death in MA-10 cells. Moreover, four AR subtype agonists induced cell death in a dose-dependent manner, and four AR subtype antagonists could all rescue cell death under cordycepin treatment in MA-10 cells. In conclusion, cordycepin could activate adenosine subtype receptors and simultaneously induce steroidogenesis and apoptosis in MA-10 mouse Leydig tumor cells.

  13. Primary cardiac tumors

    International Nuclear Information System (INIS)

    Cardiac tumors happen to be among the less known pathologies without clear treatment standards. Even one decade ago most of the cardiac tumor diagnosis were made post mortem, and only reports of isolated cases could be found in the literature, showing the lack of interest in the investigation of these pathologies by cardiology and cardiovascular surgery specialists. With the development of echocardiography and of cardiovascular surgery, more cases of primary and metastatic cardiac tumors have been diagnosed. Many cases have been treated by palliative or curative surgical interventions, thus increasing the reports in the world literature and the experience in this field, and pointing out the real incidence of these pathologies, not being as bizarre as it had been considered. a revision of the literature will be made, in which the frequency and the suggested interventions will be reported, as well as the cases of cardiac pathology in two cardiovascular centers of the country known by the author. The echocardiographic, pathologic and histological characteristics of the representative cases will be presented, without a greater evidence level, due to the problem's incidence and the few cases reported by these centers

  14. Modeling tumor evolutionary dynamics

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    Beatriz eStransky

    2013-02-01

    Full Text Available Tumorigenesis can be seen as an evolutionary process, in which the transformation of a normal cell into a tumor cell involves a number of limiting genetic and epigenetic events, occurring in a series of discrete stages. However, not all mutations in a cell are directly involved in cancer development and it is likely that most of them (passenger mutations do not contribute in any way to tumorigenesis. Moreover, the process of tumor evolution is punctuated by selection of advantageous (driver mutations and clonal expansions. Regarding these driver mutations, it is uncertain how many limiting events are required and / or sufficient to promote a tumorigenic process or what are the values associated with the adaptive advantage of different driver mutations. In spite of the availability of high-quality cancer data, several assumptions about the mechanistic process of cancer initiation and development remain largely untested, both mathematically and statistically. Here we review the development of mathematical/computational models where some assumptions were tested and discuss the impact of these models to the field of tumor biology.

  15. Malignant intraocular tumors

    International Nuclear Information System (INIS)

    The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear

  16. Estudo retrospectivo de 1.647 tumores mamários em cães

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    José C. Oliveira Filho

    2010-02-01

    Full Text Available Tumores mamários são comuns em cães, e constituem o neoplasma mais frequente em cadelas. Este estudo tem como objetivos principais estabelecer a prevalência dos tumores mamários, e dos diferentes tipos histológicos (neoplásicos e não-neoplásicos, diagnosticados em cães no Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV-UFSM. Foram avaliados 1.304 protocolos de exames histopatológicos recebidos em 1990-2008 e 132 protocolos de necropsias realizadas em 2000-2008. Deles foram obtidos a raça, o sexo e a idade dos cães, a localização do tumor na cadeia mamária, o diagnóstico morfológico e a ocorrência de metástases. Nos protocolos de exame histopatológico, foram diagnosticados 1.495 tumores, considerando que alguns cães tinham mais de um tipo de tumor, sendo 1.465 neoplásicos e 30 não-neoplásicos. Dos neoplásicos, 390 (26,6% eram benignos e 1.075 (73,3% eram malignos, estabelecendo-se uma relação benigno: maligno de 1:2,75. Das 1.125 necropsias de cães realizadas em 2000-2008, 132 (11,6% protocolos tinham descrições de tumor de mama, perfazendo 152 diagnósticos morfológicos, dos quais 150 eram neoplásicos e dois eram não-neoplásicos. Carcinoma simples foi o tipo histológico mais prevalente tanto em biópsias como em necropsias. Nas necropsias, foram observadas metástases para linfonodos em 39 casos (29,5% e para órgãos distantes em 64 casos (53,3%.Mammary gland tumors are common in dogs and are the most common type of neoplasm of female dogs. The main purposes of this study were to establish the prevalence of the mammary gland tumors, as well as of its different histologic types (neoplastic and non-neoplastic, diagnosed in the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria. There were 1,304 biopsy reports of mammary gland tumors during 1990-2008 and 132 necropsy reports of dogs with mammary tumors in 2000-2008. Data about breed, gender, and

  17. Respiratory-driven lung tumor motion is independent of tumor size, tumor location, and pulmonary function

    International Nuclear Information System (INIS)

    Purpose: To determine whether superior-inferior lung tumor motion is predictable by tumor size or location, or pulmonary function test results. Methods and Materials: Superior-inferior tumor motion was measured on orthogonal radiographs taken during simulation of 22 patients with inoperable lung cancer diagnosed by orthogonal radiographs. Results: The tumor size averaged 5.5±3.1 cm (range 1.5-12 cm). Seven of 11 central tumors demonstrated some motion compared with 5 of 11 peripheral tumors. Four of 5 upper lobe tumors moved compared with 8 of 17 tumors that were either middle or lower lobe lesions. The mean fourth rib motion was 7.3±3.2 mm (range 2-15). The mean FeV1 was 1.8±1.2 (range 0.55-5.33. The mean diffusing capacity of the lung for carbon monoxide was 14.0±6.5 (range 7.8-21.9). The mean total lung capacity was 6.5±1.2 (range 3.3-8.4). None of these parameters correlated with tumor motion. Although lateral tumor motion could not be consistently determined, 1 tumor moved 10 mm anterior-posteriorly. Conclusions: Lung tumors often move significantly during respiration. Tumor motion is not predictable by tumor size or location, or pulmonary function test results. Therefore, tumor motion must be measured in all patients. Measurement in three dimensions will likely be necessary to maximize the irradiated lung volumes or choose beam arrangements parallel to the major axis of motion

  18. Study of Kidney Tumors in Younger Patients

    Science.gov (United States)

    2016-05-17

    Clear Cell Sarcoma of the Kidney; Congenital Mesoblastic Nephroma; Diffuse Hyperplastic Perilobar Nephroblastomatosis; Rhabdoid Tumor of the Kidney; Stage I Renal Cell Cancer; Stage I Wilms Tumor; Stage II Renal Cell Cancer; Stage II Wilms Tumor; Stage III Renal Cell Cancer; Stage III Wilms Tumor; Stage IV Renal Cell Cancer; Stage IV Wilms Tumor; Stage V Wilms Tumor

  19. Modelo de tumor de pulmão em rato com o carcinossarcoma de Walker Lung tumor model in rats with Walker’s carcinosarcoma

    Directory of Open Access Journals (Sweden)

    Antero Gomes Neto

    2002-02-01

    Full Text Available OBJETIVO: Desenvolver um modelo de tumor pulmonar em ratos com o carcinossarcoma de Walker e verificar in vivo a presença de tumor por meio de tomografia computadorizada (TC. MÉTODOS: Ratos Wistar fêmeas (n=47 foram anestesiados com pentobarbital, intubados por traqueostomia e submetidos a toracotomia para injeção no parênquima pulmonar de células do tumor de Walker ou do veículo das mesmas. O estudo consistiu de duas etapas: na primeira desenvolveu-se a técnica de implante do tumor e estabeleceu-se o número de células necessário para um bom índice de pega tumoral. Na segunda etapa, determinou-se o volume do tumor em cm³ (Dxd²/2 através de TC e necropsia (6° dia do implante, e analizou-se a sobrevida dos animais. RESULTADOS: O índice de pega do tumor foi 93,3%, sendo 81,8% na primeira etapa e 100% na segunda. A mortalidade cirúrgica foi 17,0%. As medidas dos tumores foram semelhantes (0,099 vs. 0,111 cm³ na tomografia e na necropsia, respectivamente (r=0,993; pOBJECTIVE: To develop a lung tumor model in rats using Walker’s carcinosarcoma and to verify the presence in vivo of tumors using computerized tomography (CT. METHODS: Female Wistar rats (n=47 were anesthetized with pentobarbital, intubated through tracheostomy and submitted to thoracotomy; subsequently a 50-70 mu L volume containing Walker’s tumor cells, or the suspension of these same cells, was injected into the lung parenchyma. The study consisted of two phases: in the first a tumor implantation technique was developed and the number of cells required to attain a satisfactory tumor development rate was established. In the second phase, the tumor volume in cm³ (Dxd²/2 was determined through CT scan and necropsis, and the survival rates were analyzed. RESULTS: The overall tumor development rate was 93.3%, or rather, 81.1% in the first phase and 100% in the second. The surgical mortality rate was 17.0%. The average tumor volume was similar (0.099 vs. 0.111 cm

  20. Mielencefalite espontânea dos camundongos

    Directory of Open Access Journals (Sweden)

    Hermínio Linhares

    1944-02-01

    Full Text Available 1 — Duas amostras de vírus capazes de produzir uma mielencefalite foram isoladas de dois camundongos brancos suíços, de criação, espontâneamente infetados, em um total de 7.000 animais examinados; uma terceira amostra foi obtida por trituração e filtração dos intestinos de camundongos aparentemente normais. 2 — Foram feitas separadamente dez passagens por inoculação intra¬cerebral em camundongos jovens e adultos. Verificou-se por testes de imunidade cruzada que as três amostras eram idênticas. Prossegiu-se então nas passagens com apenas uma das amostras. 3 — O poder infetante aumenta com o número de passagens: o período médio de incubação diminui e aumenta a letalidade. 4 — A infecção espontânea e experimental é descrita. A doença parece ser mais comum em animais jovens. O período de incubação varia de 5 a 30 dias. Às vêzes observa-se uma fase prodromica: fraqueza, menor atividade, dificuldade em andar; geralmente surge a paralisia flácida sem sintomas prévios, na grande maioria das vêzes, nos membros posteriores. Três formas clínicas foram observadas: super-aguda, aguda e crônica. 5 — Em camundongos normais o vírus pode ser demonstrado nas fezes e nos intestinos. Ele é comum no tubo digestivo e só ocasionalmente invade o sistema nervoso central, ou melhor, a encefalomielite e primàriamente uma doença do trato digestivo no qual a invasão do SNC é um acidente. 6 — O vírus passa através de velas de CHAMBERLAND L3 e L5, em BER KEFED V, N e W e em filtro Seitz EK, a suspensão sendo tão ativa como antes da filtração. Conserva-se bem em glicerina a 50% pelo menos 60 dias, se guardado na geladeira. Suspensão de cérebro e medula aquecida em banho-maria a 56°C por 30 minutos perde a atividade. 7 — O título variou entre 4.000 e 20.000 dmm. 8 — Obteve-se infecção por inoculação intracerebral, por instilação nasal e, com menos regularidade, por inoculação intraperitoneal; a via g

  1. Perspectivas para a pesquisa em contabilidade: o impacto dos derivativos

    Directory of Open Access Journals (Sweden)

    Alexsandro Broedel Lopes

    2001-08-01

    Full Text Available Este artigo analisa o impacto dos instrumentos financeiros derivativos para a pesquisa em contabilidade. O impacto dos derivativos é grande independentemente da linha de pesquisa adotada. Dentro do paradigma do mercado de capitais, o papel dos derivativos como antecipadores do comportamento futuro dos preços fornece oportunidades interessantes de investigação, por exemplo. Na linha de pesquisa institucional e social o tratamento contábil de tais instrumentos é visualizado tendo-se por base a busca por poder e legitimização da profissão. As características operacionais dos produtos, ambiente de regulamentação, evolução tecnológica e outros aspectos característicos fazem desses produtos bases promissoras para investigações futuras.This paper investigates the role of derivative financial instruments for the future of financial accounting research. This impact is relevant what all major research paradigms are concerned. In capital market-based research, derivative instruments play a central role in price discovery. From the institutional and social points-of-view, derivatives are components of a greater quest for legitimization and power. Their operational features, regulatory environment, technological advances and other characteristics are turning derivatives into promising research venues.

  2. DISCURSO, IDENTIDADE E SUBJETIVIDADE EM O CANDIDATO DOS POBRES

    Directory of Open Access Journals (Sweden)

    WELISSON MARQUES

    2011-01-01

    Full Text Available Propomos por meio deste artigo refletir, a priori, acerca da noção de identidade advinda dos estudos sociológicos, seguindo as reflexões de Hall (2006, Bauman (2005, Silva (2007 e Woodward (2007, como também de subjetividade a partir dos estudos de Foucault (1984; 1992; 1994; 1997 2007, e pensar a pertinência destes conceitos como complementares e que coadunam com a noção de sujeito segundo a perspectiva discursiva. Apresentaremos também uma breve reflexão sobre a noção de poder em Foucault, cuja proficuidade se dá na Análise do Discurso uma vez que o poder é constitutivo dos discursos do sujeito-enunciador. Por fim, pautados nos conceitos aqui bosquejados, empreenderemos uma breve análise de um artigo intitulado O Candidato dos Pobres publicado pela revista Veja e que faz referência ao presidente Lula no contexto do escândalo do mensalão. Destarte, percebemos por meio dos recortes analisados que o sujeito enunciador se utiliza de diversas estratégias como forma de conspurcação de seu referente - o presidente Lula.

  3. Imaging in Pediatric Infratentorial Tumors

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    S. Hajiahmadi

    2008-01-01

    Full Text Available Intracranial tumors are the second cause of malignancies in childhood following leukemia. The overall incidence varies between 1:20000 and 1:100000 in different series. They are the most common solid tumors that occur in childhood .The most important diagnostic feature of an intracranial mass is its location. They can be supratentorial or infratentorial. With the exception of the first year of life, infratentorial brain tumors are more frequent than supratentorial tumors in the first decade of life. In particular, these are cerebellar low-grade astrocytomas, medulloblastomas, brain stem gliomas and ependymomas of the fourth ventricle. .Posterior fossa tumors also are readily identified with both CT and MRI. Spectroscopy in the analysis of brain tumors has recently come on the scene but may be of limited practical value when it comes to differentiating tumors. However, CT and especially MRI are the primary imaging modalities for the investigation of brain tumors. Sonography can be used in the neonates. With modern imaging, it is relatively easy to detect the presence of a tumor in most patients. The purpose of this essay is to illustrate the imaging features of various infratentorial brain tumors to make a clue for differentiation them by these features.

  4. Mechanisms of Metastatic Tumor Dormancy

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    Mary Osisami

    2013-09-01

    Full Text Available Tumor metastasis can occur years after an apparent cure due to a phenomenon known as metastatic tumor dormancy; in which tumor masses or individual tumor cells are growth restricted for extended periods of time. This period of dormancy is induced and maintained by several mechanisms, including: (1 Tumor microenvironment factors such as cytokine expression, immunosurveillance and angiogenesis; (2 Metastasis suppressor gene activity; and (3 Cancer therapeutics. Disseminated tumor cells (DTC are the key cells that result in dormant tumors. However, many challenges exist towards isolating DTCs for mechanistic studies. The main DTC that may represent the dormant cell is the cancer stem cells (CSC as they have a slow proliferation rate. In addition to limited knowledge regarding induction of tumor dormancy, there are large gaps in knowledge regarding how tumors escape from dormancy. Emerging research into cancer stem cells, immunotherapy, and metastasis suppressor genes, may lead to new approaches for targeted anti-metastatic therapy to prevent dormancy escape. Overall, an enhanced understanding of tumor dormancy is critical for better targeting and treatment of patients to prevent cancer recurrence.

  5. Imaging tumors of the patella

    International Nuclear Information System (INIS)

    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location

  6. What is a pediatric tumor?

    Directory of Open Access Journals (Sweden)

    Mora J

    2012-11-01

    Full Text Available Jaume Mora1,21Department of Oncology, 2Developmental Tumor Biology Laboratory, Hospital Sant Joan de Deu, Fundacio Sant Joan de Deu, Barcelona, SpainAbstract: Working together with medical oncologists, the question of whether a Ewing sarcoma in a 25-year-old is a pediatric tumor comes up repeatedly. Like Ewing's, some tumors present characteristically at ages that cross over what has been set as the definition of pediatrics (15 years, 18 years, or 21 years?. Pediatric oncology textbooks, surprisingly, do not address the subject of defining a pediatric tumor. They all begin with an epidemiology chapter defining the types of tumors appearing at distinct stages of childhood, adolescence, and young adulthood. Describing the epidemiology of tumors in relation to age, it becomes clear that the disease is related to the phenomenon of aging. The question, however, remains: is there a biological definition of what pediatric age is? And if so, will tumors occurring during this period of life have anything to do with such biological definition? With the aim of finding an objective definition, the fundamental concepts of what defines "pediatrics" was reviewed and then the major features of tumors arising during development were analyzed. The tumors were explored from the perspective of a host immersed in the normal process of growth and development. This physiological process, from pluripotential and undifferentiated cells, makes possible the differentiation, maturation, organization, and function of tissues, organs, and apparatus. A biological definition of pediatric tumors and the infancy–childhood–puberty classification of developmental tumors according to the infancy–childhood–puberty model of normal human development are proposed.Keywords: growth and development, pediatric tumor, infant, childhood and adolescence, pubertal tumors

  7. Use of different simulators to quality evaluation of image quality in digital mammography; Utilizacao de diferentes simuladores na avaliacao da qualidade da imagem em mamografia digital

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Leslie S.; Coutinho, Celia M.C., E-mail: leslie@ird.gov.br, E-mail: celia@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Magalhaes, Luis A.G.; Almeida, Carlos Eduardo de, E-mail: luisalexandregm@hotmail.com, E-mail: cea71@yahoo.com.br [Universidade do Estado do Rio de Janeiro (LCR/UERJ), Rio de Janeiro, RJ (Brazil). Laboratorio de Ciencias Radiologicas

    2013-11-01

    In this study, the digital images were acquired with different exposure simulators to evaluate the quality of the image, noting the tumor mass detection, microcalcification fiber and representing regions of interest during mammography. The technical parameters of exposure depends on the thickness and composition of the breast, thus affecting the dose and image quality. The simulators were used: ACR, SBP 1054, BREAST PHANTOM CIRS and for evaluation of image quality, as well as measures kerma incident on the entrance surface (Ki) and calculating the mean glandular dose (MGD)

  8. In vivo and in vitro evaluation of dota-lanreotide radiolabelled with gallium-67; Avaliacao in vivo e in vitro do dota-lanreotideo radiomarcado com galio-67

    Energy Technology Data Exchange (ETDEWEB)

    Aldegheri, Eliane Bernardes

    2005-07-01

    One of the refinements of modern Nuclear Medicine is the capacity of providing dynamic and kinetics images of the administered radiopharmaceutical, reproducing its transport mechanism, action sites, receptor binding and excretion route. With the continues technological advances new radiopharmaceuticals have been developed in order to express higher specificity and with higher characters of affinity between receptor/complex. One radiopharmaceutical is formed by a reagent or bio molecule that has in its structure a radioisotope, that has the objectives of carrying it to the organs of affinity or to benign or malign tumoral process. Somatostatin inhibits the growing and proliferation of several tumoral cells. Somatostatin analogs bind to somatostatic receptors that are expressed in different kind of neoplasia DOTA-LANREOTIDE (DOTALAN) is an octapeptide analog to somatostatin. The interest of labeling the bio conjugate with gallium-67 in Nuclear Medicine comes from its physical, chemical and biological properties. Besides its gamma radiation, useful in the diagnosis of inflammation and infection foci, {sup 67}Ga emits Auger electrons (0.1 - 8 keV) and conversion electrons (80 - 90 keV), making it attractive to internal radiotherapy if the vectors used to lead the radionuclide to the tumoral cell are internalized. The objective of this work was to develop a methodology of labelling DOTA-LANREOTIDE with {sup 67}Ga, optimizing the labelling variables and its quality control. The novelty aspect was the comparison between labeling with national and imported {sup 67}Ga, in its original and purified forms. The purification of {sup 67}Ga was essential to reach yields higher than 90%. The radiolabelled bio conjugate peptides must be free of metallic contaminants that could compete in the labeling process. The following procedure was established after studying the labeling parameters: mass of peptide of 10 {mu}g (6nmol), pH5, final reaction volume of 170 {mu}L of the labelled

  9. Angiogenesis and tumor

    Directory of Open Access Journals (Sweden)

    Kamran Mansouri

    2010-12-01

    Full Text Available Angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in the physiologic circumstances such as embryonic development, placenta formation, and wound healing. It is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. In general, angiogenesis process is a multi-factorial and highly structured sequence of cellular events comprising migration, proliferation and differentiation of endothelial cells and finally vascular formation, maturation and remodeling.Thereby, angiogenesis inhibition as a helping agent to conventional therapies such as chemotherapy and radiation has attracted the scientists’ attentions studying in this field.

  10. Liver tumor ablation

    International Nuclear Information System (INIS)

    Minimal-invasive techniques for ablation of primary and secondary hepatic tumors gain increasingly clinical importance. This is especially true since surgical resection and classic chemotherapy is successful only in a limited number of patients. Local ablative methods incorporate chemo- (percutaneous alcohol instillation, transarterial chemoembolization), thermo- (radiofrequency-, laser-, microwave-, cryoablation, high intensive focused ultrasound) and radio-ablative techniques (interstitial brachytherapy, selective internal radiotherapy). Regarding their implementation and specific effects these methods are varying widely, nevertheless all of them have a high therapeutical efficacy together with a low complication rate in common - correct application presumed. The knowledge on specific indications and contraindications is crucial to implement these methods into multimodality therapy concepts. (orig.)

  11. Abordagens cirúrgicas para os osteomas dos seios paranasais Surgical approaches to the paranasal sinuses osteoma

    Directory of Open Access Journals (Sweden)

    Fernando O. Balieiro

    2004-04-01

    Full Text Available Os osteomas são os tumores benignos mais freqüentes dos seios paranasais, apresentam crescimento lento e são em sua maioria assintomáticos. O tratamento cirúrgico destes tumores, ainda, é um tema controverso no que tange suas indicações e a escolha da abordagem cirúrgica. Existem diversas opções cirúrgicas que vão desde as abordagens externas clássicas até as transnasais assistidas por vídeo-endoscopia. Não existem indicações formais para cada uma das abordagens devendo-se sempre levar em conta o tamanho do tumor no momento da escolha da abordagem a ser empregada. OBJETIVO: Neste estudo apresentaremos seis casos de osteomas dos seios paranasais operados no Hospital Prof. Edmundo Vasconcelos, São Paulo-SP com diferentes abordagens cirúrgicas em função de peculiaridades de cada caso, discutiremos as indicações da cirurgia e também as opções cirúrgicas mostrando as vantagens e desvantagens de cada abordagem. FORMA DE ESTUDO: Estudo de série.Osteomas are the most common benign tumors arising in the paranasal sinuses, they are slow growing tumors and most part of them are assymptomatic. The surgical treatment is a controversial issue concerning their indications and surgical approach. There are several options for surgical approaches ranging from classical external surgery to intranasal endoscopic surgery. There are no formal indications for each approach and we must consider the tumor size when indicating the best approach. AIM: In this paper we will present six cases of paranasal osteomas operated at Hospital Edmundo Vasconcelos, São Paulo-SP, Brazil, with different approaches. We are also going to discuss the indications for the surgery and these approaches concerning the advantages and disadvantages of each procedure. STUDY DESIGN: Series review.

  12. Crescimento tumoral versus estadiamento no carcinoma epidermóide de língua e soalho da boca Tumoral growth versus staging in squamous cell carcinoma of the tongue and floor of the mouth

    Directory of Open Access Journals (Sweden)

    Ali Amar

    2002-08-01

    Full Text Available OBJETIVO: Este estudo tem por objetivo avaliar a relação entre o tamanho do tumor, duração da sintomatologia e a evolução de pacientes com carcinoma epidermóide de língua e soalho bucal. MÉTODO: foram avaliados retrospectivamente 226 pacientes submetidos à ressecção de tumor primário de língua e/ou soalho da boca em combinação com esvaziamento cervical. Foi estimado o crescimento mensal do diâmetro tumoral médio (raiz quadrada da superfície/número de meses de evolução e relacionado com a presença de metástases e recidiva local. A sobrevida livre de doença foi avaliada em relação ao tamanho do tumor e à duração dos sintomas. RESULTADOS: 16% dos tumores T1 e T2 e 11% dos tumores T3 e T4 apresentaram tempo de sintomatologia igual ou inferior a um mês. A mediana de crescimento do diâmetro tumoral foi de 0,81cm/mês. Não houve diferença no crescimento tumoral entre os pacientes pN+ ou pN0; 30 pacientes desenvolveram recidiva local, sendo 15 com crescimento tumoral menor do que 0,82cm/mês e 15 no grupo com crescimento ³ 0,82cm/mês. CONCLUSÕES: A taxa de crescimento tumoral não se relacionou com o intervalo livre de doença nos pacientes que apresentaram recidiva local. Os pacientes com tumores menos extensos e menor duração dos sintomas apresentaram maior sobrevida livre de doença. O tempo de sintomatologia e a estimativa de crescimento tumoral não apresentam valor prognóstico nos carcinomas epidermóides de língua e soalho oral.BACKGROUND: The objective of this study is to evaluate the real impact of tumor size, on symptoms and evolution of patients with squamous cell carcinoma of the tongue and floor of the mouth. METHODS: after 226 neck dissections plus primary resection, were estimated the monthly growing of the medium tumor diameter (square root of surface/number of months and related with metastasis presence and local recurrence. The free disease survival were analysed in relation to tumor syze and

  13. Multiparametric classification links tumor microenvironments with tumor cell phenotype.

    Directory of Open Access Journals (Sweden)

    Bojana Gligorijevic

    2014-11-01

    Full Text Available While it has been established that a number of microenvironment components can affect the likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is poorly understood. Here we have examined microenvironment control over two different tumor cell motility phenotypes required for metastasis. By high-resolution multiphoton microscopy of mammary carcinoma in mice, we detected two phenotypes of motile tumor cells, different in locomotion speed. Only slower tumor cells exhibited protrusions with molecular, morphological, and functional characteristics associated with invadopodia. Each region in the primary tumor exhibited either fast- or slow-locomotion. To understand how the tumor microenvironment controls invadopodium formation and tumor cell locomotion, we systematically analyzed components of the microenvironment previously associated with cell invasion and migration. No single microenvironmental property was able to predict the locations of tumor cell phenotypes in the tumor if used in isolation or combined linearly. To solve this, we utilized the support vector machine (SVM algorithm to classify phenotypes in a nonlinear fashion. This approach identified conditions that promoted either motility phenotype. We then demonstrated that varying one of the conditions may change tumor cell behavior only in a context-dependent manner. In addition, to establish the link between phenotypes and cell fates, we photoconverted and monitored the fate of tumor cells in different microenvironments, finding that only tumor cells in the invadopodium-rich microenvironments degraded extracellular matrix (ECM and disseminated. The number of invadopodia positively correlated with degradation, while the inhibiting metalloproteases eliminated degradation and lung metastasis, consistent with a direct link among invadopodia, ECM degradation, and metastasis. We have detected and characterized two phenotypes of motile tumor cells in vivo, which

  14. Advances of Tumor Hyperthermia and Tumor Immunology in Translational Medicine

    Institute of Scientific and Technical Information of China (English)

    Hooshang Lahooti

    2015-01-01

    Hyperthermia is another important method in the treatment of tumors, secondary to surgery, radiotherapy, chemotherapy and biotherapy. It has been demonstrated the efifcacy and versatility of hyperthermia in a lot of randomized trials across various primary cancers. Both heat shock proteins (HSPs) and dendritic cells (DCs) are greatly affected by hyperthermia and closely related to the tumor immunology. Nowadays, tumor hyperthermia and tumor immunology have been attached much attention in the field of translational medicine. In this article, the action mechanism and immunological effects of hyperthermia, activation of HSPs and DCs as well as HSP- and DC-based cancer vaccine were reviewed from the perspective of translational medicine.

  15. Igualdade na diversidade: a luta pelo reconhecimento dos direitos dos homossexuais no Brasil

    Directory of Open Access Journals (Sweden)

    Osvaldo F. R. L. Fernandez

    2011-08-01

    Full Text Available Este artigo procura refletir sobre como a sistemática discriminação e violência contra os homossexuais, o que impede o próprio incremento da cidadania no Brasil, pois torna estruturalmente sancionada a exclusão e a desigualdade social. A principal questão é demonstrar que os preceitos constitucionais e os direitos fundamentais são violados quando são negados aos LGBT o direito à vida, à dignidade e à segurança. Assim, será defendida a tese de que a proteção e a promoção dos direitos desse segmento específico da sociedade significa também um ganho geral para o exercício da cidadania.

  16. Imaging Tumor Necrosis with Ferumoxytol.

    Directory of Open Access Journals (Sweden)

    Maryam Aghighi

    Full Text Available Ultra-small superparamagnetic iron oxide nanoparticles (USPIO are promising contrast agents for magnetic resonance imaging (MRI. USPIO mediated proton relaxation rate enhancement is strongly dependent on compartmentalization of the agent and can vary depending on their intracellular or extracellular location in the tumor microenvironment. We compared the T1- and T2-enhancement pattern of intracellular and extracellular USPIO in mouse models of cancer and pilot data from patients. A better understanding of these MR signal effects will enable non-invasive characterizations of the composition of the tumor microenvironment.Six 4T1 and six MMTV-PyMT mammary tumors were grown in mice and imaged with ferumoxytol-enhanced MRI. R1 relaxation rates were calculated for different tumor types and different tumor areas and compared with histology. The transendothelial leakage rate of ferumoxytol was obtained by our measured relaxivity of ferumoxytol and compared between different tumor types, using a t-test. Additionally, 3 patients with malignant sarcomas were imaged with ferumoxytol-enhanced MRI. T1- and T2-enhancement patterns were compared with histopathology in a descriptive manner as a proof of concept for clinical translation of our observations.4T1 tumors showed central areas of high signal on T1 and low signal on T2 weighted MR images, which corresponded to extracellular nanoparticles in a necrotic core on histopathology. MMTV-PyMT tumors showed little change on T1 but decreased signal on T2 weighted images, which correlated to compartmentalized nanoparticles in tumor associated macrophages. Only 4T1 tumors demonstrated significantly increased R1 relaxation rates of the tumor core compared to the tumor periphery (p<0.001. Transendothelial USPIO leakage was significantly higher for 4T1 tumors (3.4±0.9x10-3 mL/min/100cm3 compared to MMTV-PyMT tumors (1.0±0.9x10-3 mL/min/100 cm3. Likewise, ferumoxytol imaging in patients showed similar findings with

  17. o caso dos produtos turísticos

    OpenAIRE

    Martins, Carmen Luisa Palhau

    2013-01-01

    Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos de obtenção do grau de Mestre em Ciências da Comunicação, Ramo de Marketing e Publicidade A presente dissertação de mestrado tem como tema A Influência da Internet no Processo de Decisão de Compra do Consumidor, em específico o estudo de caso dos produtos turísticos. O objectivo geral é procurar entender a influência da internet no processo de decisão de compra no caso específico dos produtos turísticos onl...

  18. Tumor triquilemal proliferante

    Directory of Open Access Journals (Sweden)

    Fulin Yu-Tseng

    2015-09-01

    Full Text Available El tumor triquilemal proliferante es una dermatosis tumoral poco frecuente y derivada de la capa externa de la raíz del folículo piloso. Generalmente, es de características benignas, tiende a ser recidivante y se han reportado casos de transformaciones malignas en la bibliografía mundial. El caso trata de una paciente femenina de 59 años, con una neoformación exofítica nodular lobulada de crecimiento lento en piel cabelluda, de 5 años de evolución, con recidivas después de 3 cirugías. No se documentó compromiso óseo ni cerebral en los estudios de gabinete. La biopsia mostró proliferación de nidos de células escamosas en dermis, separados por bandas de tejido fibroso de la epidermis. El abordaje quirúrgico es el tratamiento de elección de esta patología.

  19. NANOROBOTS IN BRAIN TUMOR

    Directory of Open Access Journals (Sweden)

    Sayyed Tarannum, Garje Dattatray H

    2011-02-01

    Full Text Available Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. In the relatively near term, nanomedicine can address many important medical problems by using nanoscale-structured materials and simple nanodevices that can be manufactured today, including the interaction of nanostructured materials with biological systems. The authors predict that technology-assisted medicine and robotics in particular, will have a significant impact over the next few decades. Robots will augment the surgeon’s motor performance, diagnosis capability, and senses with haptics (feel, augmented reality (sight, and ultrasound (sound. Robotic devices have been used in cardiac surgery, urology, fetal surgery, pediatrics, neurosurgery, orthopedics, and many other medical disciplines. In this article, we present the Nanorobot drug delivery to brain tumor, paying special attention to the transformation trends of organizations, and the integration of robots in brain tumor and underscoring potential repercussions which may deserve more attention and further research.

  20. Pericytes limit tumor cell metastasis

    DEFF Research Database (Denmark)

    Xian, Xiaojie; Håkansson, Joakim; Ståhlberg, Anders;

    2006-01-01

    Previously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions...... and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by...... stabilizing the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied beta cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes...

  1. Dynamic CT of pancreatic tumors

    Energy Technology Data Exchange (ETDEWEB)

    Hosoki, T.

    1983-05-01

    Dynamic computed tomography was performed on 19 patients with clinically diagnosed pancreatic and peripancreatic tumors. There were 10 patients with pancreatic cancer, three with inflammatory pancreatic masses, two with cystadenoma, one with insuloma, and three with peripancreatic tumors. Computed tomography was performed with a Varian-V-360-3 scanner; scanning was for 30 consecutive sec at 3 sec intervals after the bolus injection of 50 ml of contrast medium into the antecubital vein. Dynamic computed tomography (CT) may be more useful than conventional contrast CT because it facilitates: (1) correct evaluation of tumor vascularity allowing a differential diagnosis; (2) location of the boundary between tumor and a nontumor tissue; (3) detection of small tumors; and (4) visualization of pancreatic invasion by peripancreatic tumors. In addition, contrast enhancement and the degree of vascular proliferation can be quantitatively assessed by analyzing time-density curves.

  2. Dynamic CT of pancreatic tumors

    International Nuclear Information System (INIS)

    Dynamic computed tomography was performed on 19 patients with clinically diagnosed pancreatic and peripancreatic tumors. There were 10 patients with pancreatic cancer, three with inflammatory pancreatic masses, two with cystadenoma, one with insuloma, and three with peripancreatic tumors. Computed tomography was performed with a Varian-V-360-3 scanner; scanning was for 30 consecutive sec at 3 sec intervals after the bolus injection of 50 ml of contrast medium into the antecubital vein. Dynamic computed tomography (CT) may be more useful than conventional contrast CT because it facilitates: (1) correct evaluation of tumor vascularity allowing a differential diagnosis; (2) location of the boundary between tumor and a nontumor tissue; (3) detection of small tumors; and (4) visualization of pancreatic invasion by peripancreatic tumors. In addition, contrast enhancement and the degree of vascular proliferation can be quantitatively assessed by analyzing time-density curves

  3. Primary omental yolk sac tumor.

    Science.gov (United States)

    Lim, Seon Hwa; Kim, Yon Hee; Yim, Ga Won; Nam, Eun Ji; Kim, Young Tae; Kim, Sunghoon

    2013-11-01

    Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules. Explorative laparotomy was performed and then the findings from frozen biopsy of omentum were suggestive of poorly differentiated tumor though whether it was primary or metastatic was uncertain. Thus, staging laparotomy were performed. Histopathology confirmed that the tumor was a yolk sac tumor of omentum origin. Then, 6 cycles of postoperative adjuvant chemotherapy at intervals of 3 weeks were performed using bleomycin, etoposide, and cisplatin regimen. Four-year outpatient follow-up thereafter showed no relapse. PMID:24396822

  4. Comprometimento órbito-craniano por tumores malignos sinonasais: estudo por tomografia computadorizada Sinonasal malignant tumors involvement of the orbit and skull: a computed tomography study

    Directory of Open Access Journals (Sweden)

    Ana Célia Baptista

    2002-10-01

    Full Text Available Tumores malignos das cavidades sinonasais são raros e freqüentemente diagnosticados em estágio avançado da doença. A extensão destes tumores para locais críticos como a órbita e o crânio gera dificuldades no tratamento destas lesões. Dez pacientes com neoplasia maligna sinonasal, sem qualquer tratamento prévio e com evidência radiológica de extensão órbito-craniana, foram estudados por tomografia computadorizada. Dos dez tumores, cinco (50% foram neoplasias epiteliais, tendo sido a mais comum o carcinoma epidermóide (três casos. O sítio de origem tumoral mais comum foi o seio etmoidal, em quatro pacientes (40%, seguido pelo seio maxilar (30% e pela fossa nasal (30%. Dezesseis órbitas foram comprometidas, já que seis pacientes (60% apresentaram acometimento orbitário tumoral bilateral. Os tumores se estenderam mais freqüentemente para as órbitas através de erosão da parede medial e do soalho orbitários. A maioria das órbitas teve todos os compartimentos acometidos. Extensão dos tumores para a cavidade craniana foi mais comum através do teto etmoidal (70% e teto orbitário (30%. A fossa craniana anterior foi acometida em oito casos (80%, seguida pela fossa craniana média (40% e pelo lobo frontal (excluindo-se a fossa anterior (30%. Trinta e sete regiões da face foram acometidas pelos dez tumores, excluindo-se o sítio de origem da neoplasia e a região órbito-craniana, corroborando a grande extensão loco-regional do tumor no momento do diagnóstico.Malignant tumors of the sinonasal cavities are rare and often diagnosed late in the course of the disease. These tumors can extend into regions such as the orbit and brain, where treatment is difficult. Ten patients with nontreated sinonasal malignant neoplasms and radiological evidence of tumor extension into the orbit and brain were studied with computed tomography. Five (50% tumors were epithelial neoplasms whereas squamous cell carcinoma was the most common type (3

  5. Evaluation of environmental impacts in the mining of solid fossil fuels; Avaliacao de impactos ambientais na mineracao de combustiveis fosseis solidos

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Gilda Carneiro

    1989-07-01

    This study evaluates the environmental problems caused by the mining works of coal, peat and oil schists; also it evaluates the kind of treatment used by the mining companies against water, air and ground pollution, as well as the necessary control according to the mine activities and the affected environment. the studied areas are situated at brasilian states of Santa Catarina (Criciuma, Urussanga and Sideropolis), Rio Grande do Sul (Charqueada, Bage, Cachoeira do Sul, Butia and Arroio dos Ratos), Parana (Figueira and Sao Mateus do Sul), and Sao Paulo (Iguape and Sao Jose dos Campos). This study was done through a direct inquiry, by sending questionnaire to fifteen coal mining companies, three of peat ones and one of oil schists one. besides it was done a compilation of federal and state laws concerning to the environment and on the rights and duties of the mining companies. The information brought up in this way were compiled into a data bank, which allowed and sample surveys of environmental condition in the different industries and further it enabled a comparison between the real facts and the bibliography suggestions about adequate monitoring of the air, waters and ground, during mining activities. this analysis showed that the environment problems, created by the three former kind of mining works, are under control through projects of environment restoring and monitoring in phase of implantation and that these projects are restricted to that less expensive and easier to construct (holding back in pools or reservoirs, pouring in pits and aspersion). It was not notices a significant monitoring of parameters considered to be critical to the environment (metals, cyanides, sulphide and general bacteria). Almost all the companies have not yet exact data about the efficiency of each kind of environmental treatment because it is new ones and are just in follow-up and consequently they have not yet parameters to change the adequate the steps of the treatment, because

  6. Proton Therapy for Thoracoabdominal Tumors

    Science.gov (United States)

    Sakurai, Hideyuki; Okumura, Toshiyuki; Sugahara, Shinji; Nakayama, Hidetsugu; Tokuuye, Koichi

    In advanced-stage disease of certain thoracoabdominal tumors, proton therapy (PT) with concurrent chemotherapy may be an option to reduce side effects. Several technological developments, including a respiratory gating system and implantation of fiducial markers for image guided radiation therapy (IGRT), are necessary for the treatment in thoracoabdominal tumors. In this chapter, the role of PT for tumors of the lung, the esophagus, and liver are discussed.

  7. Treatment of Pediatric Brain Tumors

    OpenAIRE

    Karajannis, Matthias; Allen, Jeffrey C.; Newcomb, Elizabeth W.

    2008-01-01

    Over the past decades considerable advances have been made in neurosurgery, radiotherapy and chemotherapy resulting in improved survival and cure rates for children with brain tumors. Here we review four of the most common subtypes of pediatric brain tumors, low-grade and high-grade astrocytomas, medulloblastomas and ependymomas, highlighting their molecular features regarding their tumor biology and promising potential therapeutic targets that may hold promise for finding new “molecularly ta...

  8. Modeling Tumor Microenvironments In Vitro

    OpenAIRE

    Wu, Mingming; Melody A Swartz

    2014-01-01

    Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels. The emerging fields of tissue engineering and microtechnologies have opened up new possibilities for engineering physiologically relevant and spatially well-defined microenvironments. These in vitro models allow ...

  9. Sclerosing Stromal Tumor of Ovary

    OpenAIRE

    Hsiu-Huei Peng; Ting-Chang Chang; Swei Hsueh

    2003-01-01

    Sclerosing stromal tumor of the ovary is a rare ovarian disease with prevalence of 1.5%to 6% of ovarian stromal tumors. We present a 24-year-old woman with irregular menstruationfor 6 months and a self-palpable lower abdominal mass. Enucleation of the left ovariantumor was undertaken. Gross examination showed a soft elastic tumor with a smooth outersurface and diffusely white edematous stroma with scattered yellowish nodular areas on thecut surface. Histologic study showed that the cellular n...

  10. Primary omental yolk sac tumor

    OpenAIRE

    Lim, Seon Hwa; Kim, Yon Hee; Yim, Ga Won; Nam, Eun Ji; Kim, Young Tae; KIM, SUNGHOON

    2013-01-01

    Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules...

  11. Monocephalus dipygus EN CACHARROS: REPORTE DE DOS CASOS

    Directory of Open Access Journals (Sweden)

    Teresa Oviedo S

    2008-12-01

    Full Text Available Se describen dos casos de duplicación posterior congénita en cachorros. Esta malformación también conocida como Monocephalus dipygus, hace referencia a individuos dobles, caracterizados por tener cabeza y tórax fusionados en uno solo, duplicidad simétrica de pelvis y miembros posteriores. El primer caso, presentó cuatro miembros anteriores, cuatro miembros posteriores y palatosquisis. El segundo caso, presentó dos miembros anteriores y cuatro miembros posteriores. En general, ambos casos pueden ser relacionados como gemelos fusionados simétricos.

  12. Impacto dos incentivos fiscais e parafiscais no apoio ao emprego

    OpenAIRE

    Ferreira, Licínia Isabel dos Santos

    2011-01-01

    A presente investigação tem como objectivo analisar “o impacto dos incentivos fiscais e parafiscais no apoio ao emprego”; identificar os “incentivos ficais e as isenções no âmbito do apoio às empresas” , assim como verificar os seus “reflexos na contratação de trabalhadores”. Para tal, tentou-se perceber quais as políticas e legislação que estão subjacentes a estes incentivos e de que forma se colocam em prática, fomentando a contratação dos trabalhadores. A metodologia a...

  13. TENDÊNCIAS DOS ESTUDOS COM PLANTAS MEDICINAIS NO BRASIL

    OpenAIRE

    Fernanda Melo Carneiro; Maria José Pereira da Silva; Leonardo Luiz Borges; Lorena Carneiro Albernaz,; Joana Darc Pereira Costa

    2014-01-01

    As plantas medicinais são utilizadas pelo homem desde o início da história e atualmente empregadas como recursos na medicina alternativa por grande parte da população mundial. Esse uso deve-se à facilidade de acesso às plantas em relação aos medicamentos alopáticos. O objetivo deste trabalho foi, primariamente, desenvolver uma análise cienciométrica sobre as tendências dos estudos com plantas medicinais no Brasil, investigando se o número de trabalhos cresceu ao longo dos anos. Além disso, f...

  14. O uso dos audiovisuais como recurso didáctico

    OpenAIRE

    Ferreira, Eurico Costa

    2010-01-01

    Tendo em conta que a sociedade actual se rege por uma cultura tecnológica e audiovisual, o aproveitamento dos meios audiovisuais para serem usados como recursos didácticos nas escolas tem uma dupla função. Permite por um lado enquadrar o sistema de ensino nas exigências da nova sociedade, e por outro, criar um ambiente mais próximo do quotidiano dos alunos, tornando a sala de aula num local com uma ambiente mais motivador. No geral, este estudo apresenta os aspectos metodológicos da investiga...

  15. Monitoring Radiographic Brain Tumor Progression

    Directory of Open Access Journals (Sweden)

    John H. Sampson

    2011-03-01

    Full Text Available Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV through its inherent heterogeneous enhancement, growth patterns, and irregular nature has been difficult to assess for progression. Our ability to detect tumor progression radiographically remains inadequate. Despite the advanced imaging techniques, detecting tumor progression continues to be a clinical challenge. Here we review the different criteria used to detect tumor progression, and highlight the inherent challenges with detection of progression.

  16. Subarachnoid hemorrhage in pituitary tumor

    Directory of Open Access Journals (Sweden)

    Ashis Patnaik

    2013-01-01

    Full Text Available Subarachnoid hemorrhage (SAH is the bleeding into the subarachnoid space containing cerebrospinal fluid. The most common cause of SAH is trauma. Rupture of aneurysms, vascular anomalies, tumor bleeds and hypertension are other important etiologies. SAH in the setting of pituitary tumor can result from various causes. It can be due to intrinsic tumor related pathology, injury to surrounding the vessel during the operative procedure or due to an associated aneurysm. We discuss the pathological mechanisms and review relevant literature related to this interesting phenomenon. Early and accurate diagnosis of the cause of the SAH in pituitary tumors is important, as this influences the management.

  17. Mast cell tumors: clinical management

    International Nuclear Information System (INIS)

    Mast cell tumors are commonly diagnosed in small animal practice; however, appropriate treatment and prognosis remain controversial. These tumors are considered malignant in dogs but generally are benign in cats. Mast cell tumors are associated with various clinical signs that are related to the release of biologic mediators from the granules of the neoplastic cells, and these signs may be the primary presenting complaint. Clinical staging as well as histopathologic grading are important in determining the treatment of choice and prognosis. Treatment consists of several options, including surgery, radiation therapy, and chemotherapy. This article summarizes the available information regarding diagnosis, treatment, and prognosis of mast cell tumors and makes recommendations for therapy

  18. [Tumor of the Parotid Gland].

    Science.gov (United States)

    Pötzl, Teresa; Iselin, Sabine; Husner, Alexander

    2016-05-11

    Salivary gland tumors are a rare, histologically heterogeneous group of tumors which constitute approximately 4–6 % of all head and neck neoplasms. In 2/3 of cases they are benign, especially in the parotid gland. We report about a rare tumor of the parotid gland presenting as an extraskeletal chondroma. Histologically there were multiple S 100 protein-positive nests of chondrocytes. The externally completed cytology suspected a pleomorphic adenoma, nevertheless, the final histopathological findings showed another tumor entity. PMID:27167480

  19. Surgical Treatment in Uveal Tumors

    Directory of Open Access Journals (Sweden)

    Kaan Gündüz

    2014-09-01

    Full Text Available Surgical treatment in uveal tumors can be done via iridectomy, partial lamellar sclerouvectomy (PLSU and endoresection. Iridectomy is done in iris tumors without angle and ciliary body involvement. PLSU is performed in tumors with ciliary body and choroidal involvement. For this operation, a partial thickness scleral flap is dissected, the intraocular tumor is excised, and the flap is sutured back in position. PLSU surgery is done in iridociliary and ciliary body tumors with less than 3 clock hours of iris and ciliary body involvement and in choroidal tumors with a base diameter less than 15 mm. However, it can be employed in any size tumor for biopsy purposes. Potential complications of PLSU surgery include vitreous hemorrhage, cataract, retinal detachment, and endophthalmitis. Endoresection is a technique whereby the intraocular tumor is excised using vitrectomy techniques. The rationale for performing endoresection is based on the fact that irradiated uveal melanomas may be associated with exudation and neovascular glaucoma and removing the dead tumor tissue may contribute to better visual outcome. There are some centers where endoresection is done without prior radiotherapy. Allegedly, avoidance of radiation retinopathy and papillopathy are the main advantages of using endoresection without prior radiotherapy. (Turk J Ophthalmol 2014; 44: Supplement 29-34

  20. Polarography of Walker tumor submitted to radiotherapy

    International Nuclear Information System (INIS)

    A polarographic study of oxigen was done in 57 rats inoculated with walker 256 tumor and Platinum electrode implanted in muscle and in tumor. The goal of the research was the study of oxygen in tumor before and after irradiation. Tumor growth caused a decrease in tumoral oxygen. Oxigen was always lower in the tumor than in the muscle. Radiotherapy with 2000 rad (but not with 1000 rad) increased oxygen in the tumor

  1. [Ovarian germ cell tumors in girls].

    Science.gov (United States)

    Nechushkina, I V; Karseladze, A I

    2015-01-01

    Morphological structure of tumor influences on the clinical course of the disease in children with germ cell tumors. Patients with ovarian dysgerminoma at the time of diagnosis are significantly older than patients with immature teratoma and yolk sac tumor. Immature teratoma and mixed germ cell tumors are significantly larger compared to other germ cell tumors. Yolk sac tumor and embryonal carcinoma are the most common cause of emergency surgical interventions and are accompanied by rupture of tumor capsule. PMID:26087605

  2. Tumor estromal gastrointestinal: análise de fatores relacionados ao prognóstico Gastrointesinal stromal tumor: analysis of factors related to the prognostic

    Directory of Open Access Journals (Sweden)

    Rodrigo Panno Basilio de Oliveira

    2007-12-01

    Full Text Available OBJETIVO: estudar os critérios morfológicos e imunoistoquímicos relacionados ao prognóstico dos tumores estromais gastrointestinais. MÉTODOS: o estudo foi retrospectivo de 42 casos de tumor estromal gastrointestinal (GIST. Vinte e cinco casos foram obtidos no arquivo do Serviço de Anatomia Patológica do Hospital Universitário Gaffrée e Guinle e os outros dezessete, do Serviço de Anatomia Patológica do Hospital Universitário Clementino Fraga Filho. RESULTADOS: de acordo com a análise univariada os tumores maiores que 5 cm, com número de mitoses maior que 5/50 CGA, presença de necrose, de alto risco, revelaram significância em relação a redução da sobrevida (p= 0,017, 0,010, 0,001 e 0,016, respectivamente. Os outros fatores analisados (subtipo histológico, topografia e imunofenótipo não mostraram significância. CONCLUSÃO: os resultados confirmam a utilidade do grau de risco, do tamanho tumoral, do índice mitótico e da necrose como fatores preditores do comportamento biológico dos tumores estromais gastrointestinais.OBJECTIVE: study the morphologic criteria and immunohistochemical related with the prognostic of the gastrointestinal stromal tumors. METHODS: the study was retrospective of 42 cases of gastrointestinal stromal tumor (GIST. Twenty-five cases were obtained in the file of the Services of Pathological Anatomy of the Hospital Gaffrée and Guinle and the other 17 of Pathological Anatomy of the Hospital Clementino Fraga Filho. RESULTS: in agreement with the univaried analysis, the tumors largest than 5 cm, with mitoses number greater than 5/50 CGA, presence of necrosis, high risk, revealed significance with regarding the reduction of the survival (P = 0.017, 0.01, 0.001 and 0.016, respectively. The other analyzed factors (histological subtype, topography and imunophenotype they didn't show significance. CONCLUSION: the results confirm the usefulness of the risk degree, the tumorous size, the mitotic index and the

  3. Atlas geoquímico dos solos das bacias hidrográficos dos rios Douro e Mondego

    OpenAIRE

    Almeida, Luís Alberto Teixeira Dias de Meneses de

    2005-01-01

    Este trabalho tem como objectivos a caracterização geoquímica e a avaliação da aptidão natural dos solos das bacias hidrográficas dos rios Douro e Mondego, para o cultivo da vinha. Estes dois rios, têm uma importância socioeconómica para Portugal, por integraram duas das mais famosas regiões vitivinícolas que são respectivamente a região demarcada dos Vinhos do Porto e do Douro e a região demarcada do Dão. Estas duas bacias hidrográficas foram escolhidas, em face de duas raz...

  4. Dos realidades: dos maneras de habitar conviven hoy en la ciudad

    Directory of Open Access Journals (Sweden)

    Carmen Faría Larrazábal

    2007-01-01

    Full Text Available Maracaibo, centro de explotación petrolera en Venezuela, desde el siglo XVII organizó su estructura urbana mediante la cuadrícula tradicional española, cuyo tejido presentaba un grano uniforme. La dinámica de crecimiento del siglo XX aportó configuraciones diferentes: las Villas Cerradas, las cuales incorporan paradigmas que dibujan un nuevo orden espacial. El trabajo aborda dos aspectos estrechamente vinculados: por un lado, la solución habitacional ofertada a grupos socioeconómicos de niveles medio y medio-alto, y por otro, cómo estos desarrollos establecen nuevos patrones en el quehacer urbano, y nuevos códigos y significados a la memoria colectiva de sus ciudadanos. Se revisa el statu quo de la acción planificadora y constructiva de la vivienda y se presentan nuevas experiencias realizadas en la década de los 90, las cuales a través de su arquitectura de grandes murallas expresan la autoprotección y el control disciplinario de las relaciones sociales. La investigación utiliza el análisis documental, planimétrico y la observación directa de los fenómenos urbanos como instrumentos de ayuda para dibujar los cambios producidos; lo cual será útil tanto para la comprensión de los procesos y su teorización crítica, como para la enseñanza, el ejercicio de la profesión y la planificación de la ciudad

  5. O campo dos economistas franceses no fim dos anos 90: lutas de fronteira, autonomia e estrutura

    Directory of Open Access Journals (Sweden)

    Frédéric Lebaron

    2001-04-01

    Full Text Available A noção de economista, longe de simples e evidente, é objeto de numerosas lutas de definição. O exemplo do campo dos economistas franceses, analisado a partir de um conjunto de entrevistas, observações de dados prosopográficos, revela certas características dessas lutas. Estas opõem detendores de formas diferenciadas de capital, que estão elas mesmas em correspondência com posições distintas no campo do poder. Nessas lutas, estão em questão ao mesmo tempo a autonomia e a estrutura desse campo científico. A fraca autonomia relativa do campo da ciência econômica se faz acompanhar de uma forte homologia entre a estrutura desse campo e aquela do campo do poder francês em seu conjunto.The concept of the economist, rather than being a simple and evident one, is the object of numerous conflicting definitions. The example of the field of French economists, as analysed in a set of interviews and the observation of prospographical data, reveal certain characteristics of these conflicts. These struggles oppose those who detain differentiated forms of capital, which are themselves in correspondence with distinct positions in the field of power. These conflicts put into question both the autonomy and the structure of this scientific field. The relatively weak autonomy of the field of economical sciences is followed by a strong homology between the structure of this field and that of the field of French power in its entirety.

  6. Glucogenosis tipo I: reporte de dos casos en dos hermanos de Cartagena de Indias-Colombia

    Directory of Open Access Journals (Sweden)

    Alvear-Sedán Ciro

    2011-09-01

    Full Text Available CASO CLÍNICO: # 1. Producto del primer embarazo de padres no consanguíneos, con lactancia hasta los dos años. A los 18 meses deedad presentó distensión abdominal, hepatomegalia difusa no dolorosa, diarrea de mes y medio, debilidad generalizada, edemaprogresivo en cara y pies, anasarca y anemia. Vesícula, bazo y riñones normales y examen neurológico sin alteraciones. Nopresentó hipoglucemia, ácido láctico normal. Pruebas hepáticas alteradas; colesterol, triglicéridos y ácido úrico en el límitesuperior normal. Nunca convulsionó y los síntomas remitieron a los cinco años de edad. Actualmente tiene 14 años y su examenfísico es normal, con talla y peso acorde a la edad. # 2. Producto del segundo embarazo, hermano del anterior, con lactancia hastalos dos años. A los 11 meses de edad presentó cianosis generalizada sin otra sintomatología. Se descartó patología cardiaca. A losdos años presentó cuadro de un mes con distensión abdominal, pérdida de peso, astenia, adinamia, palidez generalizada,hepatomegalia, ascitis, hiperbilirrubinemia mixta con predominio de la directa. Presentó anemia. leucocitos, plaquetas, TP, TPT,proteinograma y glucemia normales. Serologías para hepatitis B negativa. Tamizaje metabólico normal. A los cuatro años presentócrisis tónico-clónica generalizada asociada a vómitos y hepatomegalia homogénea de 5 cm. TAC normal. Edad ósea retardada dedos y medio años, glucemia en ayunas de 31 mg/dL, colesterol, triglicéridos, ácido urico, LDH, AST y FAL elevados. Recibía dieta queincluía maizena antes de acostarse. A los cinco años, biopsia hepática: PAS positivo con cambios compatibles con glicogenosis tipoI. Presentó hematuria persistente, con períodos de hipoglucemia intermitente asintomática. Presentó nefromegalia. A partir de los9 años ha disminuido la hepatomegalia y nefromegalia; tuvo fractura brazo izquierdo con mala consolidación. Actualmente tiene11 años, talla baja de 120 cm

  7. Comparison of the automated evaluation of phantom mama in digital and digitalized images; Comparacao da avaliacao automatizada do phantom mama em imagens digitais e digitalizadas

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Priscila do Carmo, E-mail: pcs@cdtn.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear. Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Fac. de Medicina. Dept. de Propedeutica Complementar; Gomes, Danielle Soares; Oliveira, Marcio Alves; Nogueira, Maria do Socorro, E-mail: mnogue@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    Mammography is an essential tool for diagnosis and early detection of breast cancer if it is provided as a very good quality service. The process of evaluating the quality of radiographic images in general, and mammography in particular, can be much more accurate, practical and fast with the help of computer analysis tools. This work compare the automated methodology for the evaluation of scanned digital images the phantom mama. By applied the DIP method techniques was possible determine geometrical and radiometric images evaluated. The evaluated parameters include circular details of low contrast, contrast ratio, spatial resolution, tumor masses, optical density and background in Phantom Mama scanned and digitized images. The both results of images were evaluated. Through this comparison was possible to demonstrate that this automated methodology is presented as a promising alternative for the reduction or elimination of subjectivity in both types of images, but the Phantom Mama present insufficient parameters for spatial resolution evaluation. (author)

  8. Isolation and evaluation of cytotoxic potential of phenolic derivatives from Schinus terebinthifolius Raddi (Anacardiaceae); Isolamento e avaliacao do potencial citotoxico de derivados fenolicos de Schinus terebinthifolius Raddi (Anacardiaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Jeferson S.; Sartorelli, Patricia; Lago, Joao Henrique G. [Universidade Federal de Sao Paulo (UNIFESP), Diadema, SP (Brazil). Inst. de Ciencias Ambientais, Quimicas e Farmaceuticas; Matsuo, Alisson L., E-mail: joao.lago@unifesp.br [Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP (Brazil). Dept. de Micro, Imuno e Parasitologia

    2012-07-01

    The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H{sub 2}O and hexane, CH{sub 2}Cl{sub 2}, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive. (author)

  9. Hepatic tumor volumetry

    International Nuclear Information System (INIS)

    Accurate CT quantification of hepatic tumor volume in sequential CT studies of oncology patients could provide a reliable morphologic marker of disease response to chemotherapy. At present, estimates of morphologic response are based on number and size of individual lesions. In this paper three-dimensional (3D) technique is presented. A filtering program is applied to all two-dimensional (2D) sections to increase signal-to-noise ratio while maintaining boundary delineation. A CT number histogram of normal and abnormal intrahepatic tissue derived from a representative 2D section is applied in sequence to contiguous 2D sections in 3D space. A user graphics tool is available to correct for false delineation

  10. Pediatric Intracerebral Tumors

    Directory of Open Access Journals (Sweden)

    Ersin Haciyakupoglu

    2014-06-01

    Full Text Available Histopathology, appearance, biological behaviour, cytogenesis, molecular biology, physiology and effects on the brain development of the pediatric intracerebral tumors are completely different from the tumours in adults. In adults, glioblastoma multiforme and meningiomas are seen mostly, but in children pilocytic astrocytoma, medulloblastoma and germ cell tumours are more common. When pediatric intracerebral tumours are detected, families should be supported and the physcosocial trauma affecting the family should be reduced. As pediatric intracranial tumours are located mostly in the midline, neurological symptoms of them are quite faint. As cerebrospinal fluid paths are obstructed, increased intracranial pressure symptoms appear. Special anesthetic and surgical techniques should be performed for children. Stereotactic surgery, neuroendoscopy, functional and intraoperative magnetic resonance imaging and neuromonitoring could be used. Radiotherapy (in patients aged 3 and more years old, stereotactic radiosurgery, chemotherapy and gene therapies could be performed as the other treatment modalities. [Archives Medical Review Journal 2014; 23(3.000: 367-386

  11. Gynecological tumors; Gynaekologische Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin; Nitzsche, E.U. [Freiburg Univ. (Germany). Abt. Nuklearmedizin

    2000-09-01

    Early diagnosis and accurate staging of gynecological tumors based on noninvasive imaging remains a challenge. US, CT and MRI lack sensitivity and specificity for diagnosis and staging of primary disease, residual mass and recurrent disease. FDG-PET may add some important diagnostic information, but currently available results from initial studies indicate that it will not replace other staging tools for specific questions to be answered during work-up. (orig.) [German] Fruehdiagnose und korrekte nichtinvasive bildgebende Ausbreitungsdiagnostik von gynaekologischen Tumorerkrankungen sind vorerst weiterhin eine Illusion. US, CT und MRI erreichen bisher keine akzeptable Sensitivitaet und Spezifitaet in der Primaertumordiagnostik, Tumorresiduendiagnostik und Tumorrezidivdiagnostik. Die FDG-PET wird moeglicherweise wichtige Informationen bezueglich Lymphknotenbefall und Fernmetastasierung sowie Rezidivdetektion beitragen koennen, initiale Studienergebnisse zeigen jedoch, dass sie etablierte Staginguntersuchungen gegenwaertig nicht ersetzen kann. (orig.)

  12. Cystic tumors of Pancreas

    International Nuclear Information System (INIS)

    Case material consists of five patients, four of them corresponding to cystic tumors of pancreas and one to a pseudocyst which, as literature tells us, is often difficult to differentiate from the former.There is a description of main clinical and image aspects and the conduct applied there to. This subject is in full process of development and new pathology grading is applied although the last word has yet to be said. It is very difficult to reach exact diagnosis in the pre and in the intra operative stage. As they tend to be malignant, surgical resection is advised, however without discarding enucleation.Whenever they are malignant prognosis in general is better than in the case of solid pancreatic cancer

  13. Cystic tumors of Pancreas

    International Nuclear Information System (INIS)

    Case material consist of five patients, four of them corresponding to cystic tumors of Pancreas and one to pseudocyst which, as literature tells us, is often difficult to differentiate from the former.There is a description of main clinical and image aspects and the conduct applied thereto. This subject is in full process of development and a new pathology grading is applied although the last word has yet to be said. It is very difficult to reach exact diagnosis in the pre-and in the intra-operative stage.As they tend to be malignant, surgical resection is advised, however without discarding enucleation.Whenever they are malignant prognosis in general is better than in the case of solid pancreatic cancers

  14. Cathepsins mediate tumor metastasis

    Institute of Scientific and Technical Information of China (English)

    Gong-Jun; Tan; Zheng-Ke; Peng; Jin-Ping; Lu; Fa-Qing; Tang

    2013-01-01

    Cathepsins are highly expressed in various human cancers, associated with tumor metastasis. It is superfamily, concluding A, B, C, D, E, F, G, H, L, K, O, S, V, and W family members. As a group of lysosomal proteinases or endopeptidases, each member has a different function, playing different roles in distinct tumorigenic processes such as proliferation, angiogenesis, metastasis, and invasion. Cathepsins belong to a diverse number of enzyme subtypes, including cysteine proteases, serine proteases and aspartic proteases. The contribution of cathepsins to invasion in human cancers is well documented, although the precise mechanisms by which cathepsins exert their effects are still not clear. In the present review, the role of cathepsin family members in cancer is discussed.

  15. Familial germ cell tumor

    Directory of Open Access Journals (Sweden)

    Sanju Cyriac

    2012-01-01

    Full Text Available Familial testicular germ cell tumors are well known in literature. Only few cases are reported where both brother and sister of the same family suffered from germ cell malignancies. We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presence of germ cell malignancies in the siblings of different sex in the same family points toward a genetic susceptibility. Literature review revealed only six similar cases. A discussion regarding the rare occurrence of familial germ cell malignancies with the affected family members may be worthwhile.

  16. O reconhecimento dos direitos dos povos indígenas sob a perspectiva internacional e a brasileira

    OpenAIRE

    MARIANA YOKOYA SIMONI

    2009-01-01

    O objetivo da presente análise é descrever,

    brevemente, o surgimento e a evolução do tema

    dos direitos dos povos indígenas na agenda de

    organizações internacionais – como a Organização

    Internacional do Tra...

  17. Ano Internacional dos Solos 2015: Oportunidade para promover uma administração integrada dos solos em Portugal?

    OpenAIRE

    Alexandre, Carlos; Gonçalves, Conceição; Monteiro, Fernando; Ribeiro, Henrique; Ramos, Tiago

    2015-01-01

    Resumo: Neste trabalho assinala-se o retrocesso da administração do recurso solo em Portugal ao longo dos últimos 40 anos, em contraponto com a evolução recente a nível europeu (Estratégia Temática para a Protecção do Solo) e a nível global (Parceria Global para o Solo, Dia Mundial do Solo e Ano Internacional dos Solos 2015, AIS-2015). Aproveitando o impulso internacional neste domínio apresenta-se a Parceria Portuguesa para o Solo (PPS), como mais uma iniciativa que procura inverter o proces...

  18. Análise dos modelos de “governance” e práticas dos portos Portugueses

    OpenAIRE

    Pereira , Ana Filipa Correia

    2014-01-01

    Portugal é um país rico em potencial económico marítimo, para o desenvolvimento de quaisquer atividades que tenham no mar a sua base. Atualmente, o transporte marítimo está a deslocar-se para outras regiões do mundo, nomeadamente a bacia do pacífico, sendo estas consideradas atualmente como as mais competitivas. Assim, o estudo dos modelos e práticas destas regiões poderão gerar um contributo para a inovação dos portos portugueses, tratando-se de um desafio para o setor portuá...

  19. Influência de Agaricus blazei Murrill sobre o tumor sólido de Ehrlich e linfonodos poplíteos de camundongos Influence of Agaricus blazei Murrill in solid Ehrlich tumor and popliteal lymph nodes in mice

    Directory of Open Access Journals (Sweden)

    D. Verçosa Junior

    2007-02-01

    Full Text Available Estudou-se a influência do tratamento diário com filtrado aquoso de Agaricus blazei Murrill (ABM (25mg/ml, via oral, por 17 e 57 dias, em camundongos inoculados com tumor sólido de Ehrlich (TSE por meio da curva de crescimento tumoral, do peso relativo do tumor, da contagem de regiões organizadoras de nucléolos (AgNORs e dos padrões histológicos das massas tumorais e linfonodos poplíteos. Os animais que ingeriram o extrato aquoso do ABM por 57 dias apresentaram menor (P0,05 entre os animais tratados e não tratados.The influence of daily administration of Agaricus blazei Murrill (ABM aqueous solution (25mg/ml during 17 and 57 days in mice bearing solid Ehrlich tumor was studied. Tumoral growth, tumoral and spleenic relative weights, nucleoly organization regions AgNORs values and tumor and popliteal lymph nodes histopathology were daily evaluated. The animals that received ABM during 57 days showed lower values (P0.05 between treated and non-treated animals. No difference in microscopic evaluation of the tumors in treated and non-treated animals was seen and metastasis in popliteal nodes of the tumor occurred in all the animals.

  20. Tumor mediastinal de células germinativas e sua relação com anormalidades hematológicas Mediastinal germ cell tumors and its relationship with hematological disorders

    Directory of Open Access Journals (Sweden)

    Carlos R. Medeiros

    2000-08-01

    Full Text Available Tumores mediastinais de células germinativas são raros (2% a 10% dos tumores germinativos e cerca de 100 casos são diagnosticados anualmente. Apresentam a particularidade de em um terço dos casos estarem associados a doenças hematológicas, com freqüência malignas. Duas teorias tentam explicar a origem desta associação. Na primeira, anormalidades da célula totipotencial comum a ambas as doenças seriam as responsáveis. O achado da alteração isocromossômica do cromossoma 12, tanto nos tumores mediastinais de células germinativas quanto nas células hematopoéticas componentes das anormalidades hematológicas, sugere a mesma origem para ambas as células primordiais. Na segunda, o efeito de agentes quimioterápicos usados para tratamento dos tumores mediastinais de células germinativas (principalmente o etoposide sobre uma célula tronco hematopoética instável poderia induzir ao aparecimento da neoplasia hematológica, geralmente associada a anormalidades do cromossoma 11. Habitualmente, tanto os tumores mediastinais de células germinativas quanto a anormalidade hematológica têm comportamento agressivo e são de difícil tratamento. Novas abordagens podem ser exploradas no estadiamento e tratamento destas situações.Mediastinal germ cell tumors are uncommon (2 to 10% of germ cell tumors, and around 100 new cases are diagnosed annually. Their relationship with hematological disorders is an unique aspect of these tumors. The hematological disorder may be part of the natural history of the germ cell tumor, both sharing the same abnormal totipotential stem cell. The two most common hematological neoplasms seen in this syndrome are acute leukemia and malignant histiocytosis. The finding of the marker chromosome isochromosome i(12p in the mediastinal germ cell tumors and associated malignant disorder is a suggestion that both tumors may arise from a common progenitor cell. A more remote possibility is that the hematological

  1. Empreededorismo social: caso da 'cidade dos meninos' Belo Horizonte - Brasil

    Directory of Open Access Journals (Sweden)

    Walter Marinho de Oliveira

    2010-09-01

    Full Text Available A Cidade dos Meninos de São Vicente de Paulo, é uma das mais ousadas e completas abordagens no enfrentamento do problema dos menores de rua no Brasil. Este artigo, descreve a experiência da “Cidade dos Meninos” e de seu idealizador, apoiando-se em teorias recentes sobre empreendedorismo social. Atenção especial é dada à definição de empreendedor social catalítico (WADDOCK; POST, 1991, relacionando a atuação da liderança da Cidade dos Meninos a esse perfil. Uma das possíveis conclusões é que, em países em desenvolvimento como o Brasil, o empreendedor social catalítico não pode exercer apenas a função de criador e implementador de políticas, face a dimensão da carência e do problema com o qual ele se confronta, envolvendo-se então na ação direta

  2. DOS VALORES INDIVIDUALISTAS AOS CAMINHOS DE SUPERAÇÃO

    Directory of Open Access Journals (Sweden)

    Róber Iturriet Avila

    2014-08-01

    Full Text Available 800x600 Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Este artigo se propõe averiguar as fontes dos valores individualistas na sociedade contemporânea. Para tanto, eles serão analisados por dois fatos geradores; i pela influência dos intelectuais nestes valores e; ii pelo condicionamento dos homens diante do arranjo econômico. Pauta ainda este trabalho as maneiras de mitigar tais valores, no tempo em que se gestam valores coletivistas. Este papel é analisado a partir de dois prismas i pelo papel dos intelectuais na formação de valores; ii a partir do sistema educacional que os potencialize. Assim, este trabalho versa, adicionalmente, sobre como a educação formal pode ter um papel importante na transformação cultural de uma sociedade.

  3. Stealth-MITM DoS Attacks on Secure Channels

    CERN Document Server

    Herzberg, Amir

    2009-01-01

    We define stealth Man-in-the-Middle adversaries, and analyse their ability to launch denial and degradation of service (DoS) attacks on secure channels. We show realistic attacks, disrupting TCP communication over secure VPNs using IPsec. We present: First amplifying DoS attack on IPsec, when deployed without anti-replay window. First amplifying attack on IPsec, when deployed with a `small' anti-replay window, and analysis of `sufficient' window size. First amplifying attack on IPsec, when deployed with `sufficient' window size. This attack (as the previous) is realistic: attacker needs only to duplicate and speed-up few packets. We also suggest a solution designed to prevent the presented attacks, and to provide secure channel immune to degradation and other DoS attacks. Our solution involves changes (only) to the two gateway machines running IPsec. In addition to their practical importance, our results also raise the challenge of formally defining secure channels immune to DoS and degradation attacks, and p...

  4. From oncogenes to tumor antigens

    International Nuclear Information System (INIS)

    This book presents 26 manuscripts which comprise comprehensive reviews and recent experimental data from four main areas of cancer research: oncogenes, transforming proteins and growth factors; immunodeficiencies and tumors; new markers for tumor immunodiagnosis; and prospects of immunological cancer treatment. (Auth.)

  5. [Recent advances in transmissible tumors].

    Science.gov (United States)

    Tingting, Yin; Lu, Wang; Guodong, Wang

    2015-11-01

    Transmissible tumors are a class of tumor that can be transmitted between individuals through living cells. So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters reticulum cell sarcoma (HRCS)have been discovered and identified. In the last decades, these transmissible tumors have been proved to be transmitted through living cells by cytological, histological and genetic studies. CTVT, the oldest mammalian somatic cell line, and DFTD originated from Schwann cell have been reported to avoid immunological recognition by down-regulating MHC expression, while a high copy number of Steamer retrotransposon is commonly exist in SSCL. In recent years, the whole-genome sequencing of CTVT and DFTD have been completed which facilitates studies on the mechanisms of tumorigenesis, transmission and evolution of transmissible tumors at the whole-genome level. In this review, we summarize the recent advances in transmissible tumors and discuss the research focus in next decade. PMID:26582522

  6. Imaging probe for tumor malignancy

    Science.gov (United States)

    Tanaka, Shotaro; Kizaka-Kondoh, Shinae; Hiraoka, Hasahiro

    2009-02-01

    Solid tumors possess unique microenvironments that are exposed to chronic hypoxic conditions ("tumor hypoxia"). Although more than half a century has passed since it was suggested that tumor hypoxia correlated with poor treatment outcomes and contributed to cancer recurrence, a fundamental solution to this problem has yet to be found. Hypoxia-inducible factor (HIF-1) is the main transcription factor that regulates the cellular response to hypoxia. It induces various genes whose functions are strongly associated with malignant alteration of the entire tumor. The cellular changes induced by HIF-1 are extremely important targets of cancer therapy, particularly in therapy against refractory cancers. Imaging of the HIF-1-active microenvironment is therefore important for cancer therapy. To image HIF-1activity in vivo, we developed a PTD-ODD fusion protein, POHA, which was uniquely labeled with near-infrared fluorescent dye at the C-terminal. POHA has two functional domains: protein transduction domain (PTD) and VHL-mediated protein destruction motif in oxygen-dependent degradation (ODD) domain of the alpha subunit of HIF-1 (HIF-1α). It can therefore be delivered to the entire body and remain stabilized in the HIF-1-active cells. When it was intravenously injected into tumor-bearing mice, a tumor-specific fluorescence signal was detected in the tumor 6 h after the injection. These results suggest that POHA can be used an imaging probe for tumor malignancy.

  7. Tumors of the optic nerve

    DEFF Research Database (Denmark)

    Lindegaard, Jens; Heegaard, Steffen

    2009-01-01

    the nerve (e.g., astrocytes and meningothelial cells). The optic nerve may also be invaded from tumors originating elsewhere (secondary tumors), invading the nerve from adjacent structures (e.g., choroidal melanoma and retinoblastoma) or from distant sites (e.g., lymphocytic infiltration and distant...

  8. Surgical strategies in endocrine tumors

    NARCIS (Netherlands)

    Schreinemakers, J.M.J.

    2010-01-01

    Endocrine surgery has become more custom-made throughout the years. Endocrine tumors can be sporadic or develop as part of familial syndromes. Several familial syndromes are known to cause endocrine tumors. The most common are multiple endocrine neoplasia (MEN) syndromes type 1, 2A and 2B. This thes

  9. Living with a Brain Tumor

    Science.gov (United States)

    ... when you have been diagnosed with a brain tumor diagnosis. Dealing with changes to your appearance – such as losing your hair or losing weight is difficult for most of us. Keep in mind that your life is not so much ... with a brain tumor may mean rethinking your work and professional goals, ...

  10. Brain Tumor Epidemiology Consortium (BTEC)

    Science.gov (United States)

    The Brain Tumor Epidemiology Consortium is an open scientific forum organized to foster the development of multi-center, international and inter-disciplinary collaborations that will lead to a better understanding of the etiology, outcomes, and prevention of brain tumors.

  11. [Local treatment of liver tumors

    DEFF Research Database (Denmark)

    Pless, T.K.; Skjoldbye, Bjørn Ole

    2008-01-01

    Local treatment of non-resectable liver tumors is common. This brief review describes the local treatment techniques used in Denmark. The techniques are evaluated according to the evidence in literature. The primary local treatment is Radiofrequency Ablation of both primary liver tumors and liver...

  12. Self-scaling tumor growth

    DEFF Research Database (Denmark)

    Schmiegel, Jürgen

    We study the statistical properties of the star-shaped approximation of in vitro tumor profiles. The emphasis is on the two-point correlation structure of the radii of the tumor as a function of time and angle. In particular, we show that spatial two-point correlators follow a cosine law. Further...

  13. Benign mixed tumor of the lacrimal sac

    Directory of Open Access Journals (Sweden)

    Jong-Suk Lee

    2015-01-01

    Full Text Available Neoplasms of the lacrimal drainage system are uncommon, but potentially life-threatening and are often difficult to diagnose. Among primary lacrimal sac tumors, benign mixed tumors are extremely rare. Histologically, benign mixed tumors have been classified as a type of benign epithelial tumor. Here we report a case of benign mixed tumor of the lacrimal sac.

  14. Melanotic neuroectodermal tumor of infancy

    International Nuclear Information System (INIS)

    Melanotic neuroectodermal tumor of infancy is an uncommon neoplasm occurring primarily in the child one year or less in age. Difficulty in deciding the cellular origin of this tumor has led to numerous names, including congenital melanocarcinoma, melanotic epithelial odontoma, melanotic ameloblastoma, and retinal anlage tumor, to list a few. Electron microscopy and histochemical studies, however, have now established the neural crest the most likely origin. The most frequent site of occurrence is the maxilla followed by the skull, the brain and the mandible. The genital organs are the most frequent extracranial site. Within the skull, there is a predilection for the anterior fontanel. The following is a case report of a young child with melanotic neuroectodermal tumor of infancy arising at the anterior fontanel. Included is a discussion of magnetic resonance (MR) findings, which to our knowledge, have not been previously reported in this tumor. (orig.)

  15. Metabolic exchanges within tumor microenvironment.

    Science.gov (United States)

    Chiarugi, Paola; Cirri, Paolo

    2016-09-28

    Tumor progression toward malignancy often requires a metabolic rewiring of cancer cells to meet changes in metabolic demand to forefront nutrient and oxygen withdrawal, together with strong anabolic requests to match high proliferation rate. Tumor microenvironment highly contributes to metabolic rewiring of cancer cells, fostering complete nutrient exploitation, favoring OXPHOS of lipids and glutamine at the expense of glycolysis and enhancing exchanges via extracellular microvesicles or exosomes of proteins, lipids and small RNAs among tumor and stromal cells. Noteworthy, the same molecular drivers of metabolic reprogramming within tumor and stroma are also able to elicit motility, survival and self-renewal on cancer cells, thereby sustaining successful escaping strategies to circumvent the hostile hypoxic, acidic and inflammatory environment. This review highlights the emerging role of nutrients and vesicle-mediated exchanges among tumor and stromal cells, defining their molecular pathways and offering new perspectives to develop treatments targeting this complex metabolic rewiring. PMID:26546872

  16. Estudo dos elementos celulares na medula humana dos adultos I. linhagem plasmocitária

    Directory of Open Access Journals (Sweden)

    M. R. Q de Kastner

    1972-01-01

    Full Text Available Examinando o conjunto dos resultados obtidos nesta pesquisa e os dados pela literatura, observamos que o aumento numérico de células plasmáticas na medula óssea é um fenômeno relativamente freqüente. Todo hematologista habituado pode facilmente fazer o diagnóstico do estado da célula plasmocitária pela sua morfologia, seu tamanho e sua coloração. Nos quadros mais proeminentes de predominância de células de linhagem plasmocitária, os exames hematológicos e clínicos aliados ao mielograma, auxiliarão no diagnóstico do plasmocitoma. A nosso ver, os sinais (qualitativos, distintivos, de natureza citológica, que aparecem nos mielogramas no caso de plasmocitoma são: a Pleomorfismo e dismorfismo na célula plasmática; b "Rouleaux" de hemácias, já visível no hemograma; c Aumento das dimensões de alguns metamielócitos e bastonetes, acompanhados geralmente de atipias nucleares. Atipias e plurissegmentação nos segmentados; d No setor plaquetogenético aparecem plaquetas grandes e certo grau de perturbação nos megacarióticos, traduzido ás vezes pela presença de núcleos nus.Two hundred fifty bone marrow specimens, including twenty seven from hematologically normal patients, were examined hitologically. The Wright's and Brachet's stains were used. Plasma cells were rarely seen in the peripheral blood and bone marrow of normal individuals, but they were prominent constituents in some pathological states. A number significantly increased of plasma cells or mieloma cells were usually recognized in bone marrow from patients with plasmacytoma. These cells ranged from a very anaplastic immature form to closely resembling plasma cell. Even in the same patient, considerable pleomorphism often occured, and variation in cell size, number of nuclei and degree of nuclear immaturity were common. Although the results report certain observations regarding to the other cell series in patients with plasmacytoma. The most suggestive evidences

  17. Complicações oftálmicas em pacientes com tumores malignos extra-orbitários Ophthalmic complications in patients with extraorbital malignant tumors

    Directory of Open Access Journals (Sweden)

    Ana Célia Baptista

    2003-10-01

    Full Text Available OBJETIVO: Correlacionar as complicações oftálmicas, presentes em pacientes portadores de tumores malignos extra-orbitários, com o sítio de origem e diagnóstico histopatológico destas neoplasias, por meio de tomografia computadorizada. MÉTODOS: Foram estudados retrospectivamente, por tomografia computadorizada, 29 pacientes com neoplasias malignas extra-orbitárias, sem qualquer tratamento prévio do tumor, e evidência clínico-radiológica de comprometimento orbitário associado. RESULTADOS: Houve predomínio do carcinoma epidermóide (28%, seguido pelo carcinoma basocelular (14%. As complicações oftálmicas mais comumente observadas foram proptose (38%, epífora (24% e dor ocular (24%. Redução da acuidade visual foi referida em 14 % dos casos. Os sítios de origem mais comuns das neoplasias foram o seio maxilar (28%, o seio etmoidal (17% e a pele e subcutâneo da face (17%. Proptose ocular foi causada predominantemente por tumores não carcinomatosos e tumores originados no seio etmoidal, ao passo que epífora ocorreu preferencialmente nos casos de tumores carcinomatosos e de neoplasias do seio maxilar. Redução da motilidade ocular, irritação ocular e secreção no olho foram as complicações oftálmicas mais freqüentes em pacientes com tumores dos anexos oculares, ao passo que dor ocular foi a complicação oftálmica dominante nos pacientes com neoplasias originadas na pele e subcutâneo da face. CONCLUSÕES: Os autores sugerem que, diante de paciente com epífora e massa maxilo-nasal, carcinoma do seio maxilar deve ser considerado primariamente no diagnóstico diferencial da lesão. Da mesma forma, tumores não carcinomatosos, como sarcomas e linfomas, devem ser considerados, sobretudo no diagnóstico de pacientes com proptose e massa naso-etmoidal.OBJECTIVE: To correlate the ophthalmic complications in patients with extra-orbital malignant tumors with the site of origin and histopathologic diagnosis of the tumors by

  18. A autoavaliação como instrumento de autorregulação dos progressos dos alunos

    OpenAIRE

    Marques, Rogério de Oliveira

    2015-01-01

    Este trabalho tem como objetivo promover uma reflexão sobre a importância da autoavaliação dos alunos no desencadear de mecanismos pessoais que lhes permitam adquirir hábitos de autorregulação das suas aprendizagens.

  19. Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis

    DEFF Research Database (Denmark)

    Jiang, Xinnong; Multhaupt, Hinke; Chan, En; Schaefer, Liliana; Schaefer, Roland M; Couchman, John R

    2004-01-01

    As a major heparan sulfate proteoglycan (PG) in basement membranes, perlecan has been linked to tumor invasion, metastasis, and angiogenesis. Here we produced epidermal tumors in immunocompromised rats by injection of mouse RT101 tumor cells. Tumor sections stained with species-specific perlecan...... factor. In vivo, antisense perlecan-transfected cells generated no tumors, whereas untransfected and vector-transfected cells formed tumors with obvious neovascularization, suggesting that tumor perlecan rather than host perlecan controls tumor growth and angiogenesis....

  20. IMRT in hypopharyngeal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Studer, G.; Luetolf, U.M.; Davis, J.B.; Glanzmann, C. [Dept. of Radiation Oncology, Univ. Hospital, Zurich (Switzerland)

    2006-06-15

    Background and purpose: intensity-modulated radiation therapy (IMRT) data on hypopharyngeal cancer (HC) are scant. In this study, the authors report on early results in an own HC patient cohort treated with IMRT. A more favorable outcome as compared to historical data on conventional radiation techniques was expected. Patients and methods: 29 consecutive HC patients were treated with simultaneous integrated boost (SIB) IMRT between 01/2002 and 07/2005 (mean follow-up 16 months, range 4-44 months). Doses of 60-71 Gy with 2.0-2.2 Gy/fraction were applied. 26/29 patients were definitively irradiated, 86% received simultaneous cisplatin-based chemotherapy. 60% presented with locally advanced disease (T3/4 Nx, Tx N2c/3). Mean primary tumor volume measured 36.2 cm{sup 3} (4-170 cm{sup 3}), mean nodal volume 16.6 cm{sup 3} (0-97 cm{sup 3}). Results: 2-year actuarial local, nodal, distant control, and overall disease-free survival were 90%, 93%, 93%, and 90%, respectively. In 2/4 patients with persistent disease (nodal in one, primary in three), salvage surgery was performed. The mean dose to the spinal cord (extension of > 5-15 mm) was 26 Gy (12-38 Gy); the mean maximum (point) dose was 44.4 Gy (26-58.9 Gy). One grade (G) 3 dysphagia and two G4 reactions (laryngeal fibrosis, dysphagia), both following the schedule with 2.2 Gy per fraction, have been observed so far. Larynx preservation was achieved in 25/26 of the definitively irradiated patients (one underwent a salvage laryngectomy); 23 had no or minimal dysphagia (G0-1). Conclusion: excellent early disease control and high patient satisfaction with swallowing function in HC following SIB IMRT were observed; these results need to be confirmed based on a longer follow-up period. In order to avoid G4 reactions, SIB doses of < 2.2 Gy/fraction are recommended for large tumors involving laryngeal structures. (orig.)

  1. ABT-751 in Treating Young Patients With Refractory Solid Tumors

    Science.gov (United States)

    2012-03-14

    Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Kidney Cancer; Liver Cancer; Neuroblastoma; Ovarian Cancer; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific

  2. Cushing syndrome due to adrenal tumor

    Science.gov (United States)

    Adrenal tumor - Cushing syndrome ... Cushing syndrome is a disorder that occurs when your body has a higher than normal level of the ... or cancerous (malignant). Noncancerous tumors that can cause ... Adrenal adenomas Micronodular hyperplasia Cancerous tumors that ...

  3. At the double for tumor suppressor

    Science.gov (United States)

    2016-01-01

    Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost. PMID:27421119

  4. Brain and Spinal Tumors: Hope through Research

    Science.gov (United States)

    ... and worsen as the tumor grows. The most obvious sign of a brain tumor in infants is ... blood flow, antidepressants to treat anxiety or ease depression that might occur following a tumor diagnosis, and ...

  5. Tumores neonatales y malformaciones congénitas

    Science.gov (United States)

    Tornero, O. Berbel; García, J.A. Ortega; Tortajada, J. Ferrís i; Castell, J. García; Colomer, J. Donat i; Soldin, O.P.; Soler, J.L. Fuster

    2013-01-01

    Introducción La asociación entre tumores y malformaciones congénitas está bien establecida, pero no existen datos exclusivos en el período neonatal y se desconocen los mecanismos subyacentes que generan dicha relación. Objetivos Este trabajo tiene dos objetivos: primero, analizar la frecuencia de los tumores neonatales asociados a malformaciones congénitas, y segundo, comentar las posibles hipótesis etiopatogénicas de la relación entre ambas entidades. Materiales y método Estudio retrospectivo de las historias clínicas de los tumores neonatales, en el Hospital Universitario Materno- Infantil La Fe de Valencia, desde enero de 1990 hasta diciembre de 1999. Selección y descripción de las variedades histológicas asociadas a malformaciones congénitas. Éstas se han agrupado siguiendo los criterios de la Clasificación Internacional de Enfermedades CIE-9, códigos 740.0–759.9. Revisión sistemática bibliográfica de los últimos 25 años, obtenida del Medline, Cancerlit, Index Citation Science y Embase. El perfil de búsqueda utilizado fue la combinación de “neonatal/congenital-tumors/cancer/neoplasms” y “congenital malformations/birth defects”. Resultados Se identificaron 72 tumores neonatales (2,8 % del total de tumores pediátricos diagnosticados en dichos años) y 15 de ellos (20,8 %) asociados a malformaciones congénitas, enfermedades o síndromes congénitos. Las asociaciones entre tumores neonatales y malformaciones congénitas fueron las siguientes: a) angioma en 3 pacientes: con dos cardiopatías congénitas y una atresia de coanas-laringomalacia; b) neuroblastoma en 2 pacientes: uno con riñón en herradura y anomalías vertebrales, y otro con cardiopatía congénita; c) teratoma en 2 pacientes: uno con fisura palatina y anomalías vertebrales, y otro con metatarso varo; d) tumor del sistema nervioso central en un paciente con hernia de Bochdaleck; e) tumor cardíaco en 4 pacientes con esclerosis tuberosa; f) leucemia aguda en un

  6. PET-CT imaging fusion in the assessment of head and neck carcinoma; Fusao de imagens PET-TC na avaliacao do carcinoma espinocelular de cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Denise Takehana dos [Sao Paulo Univ., SP (Brazil). Faculdade de Odontologia; Chojniak, Rubens [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Imagem; Lima, Eduardo Nobrega Pereira [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Medicina Nuclear; Cavalcanti, Marcelo Gusmao Paraiso [Universidade de Sao Paulo, SP (Brazil). Faculdade de Odontologia. Dept. de Estomatologia]. E-mail: mgpcaval@usp.br

    2006-11-15

    Objective: The authors have established a methodological approach to evaluate head and neck squamous cell carcinoma aiming at identifying and distinguishing high metabolic activity inside the lesion, combining in a single examination, functional, metabolic and morphological data simultaneously acquired by means of different non-dedicated positron emission tomography (PET)-computed tomography (CT) device. Materials and Methods: The study population included 17 patients with head and neck squamous cell carcinoma submitted to a non-dedicated {sup 18} F-FDG-PET imaging at Department of Diagnostic Imaging of Hospital do Cancer, Sao Paulo, SP, Brazil. CT and {sup 18} F-FDG-PET images were simultaneously acquired in a non-dedicated device. The original data were transferred to an independent workstation by means of the Entegra 2 NT software to generate PET-CT imaging fusion. Results: The findings were defined as positive in the presence of a well defined focal area of increased radiopharmaceutical uptake in regions not related with the normal biodistribution of the tracer. Conclusion: The fusion of simultaneously acquired images in a single examination ({sup 18}F-FDGPET and CT) has allowed the topographic-metabolic mapping of the lesion as well as the localization of high metabolic activity areas inside the tumor, indicating recidivation or metastasis and widening the array of alternatives for radiotherapy or surgical planning. (author)

  7. Tumor targeting via integrin ligands

    Directory of Open Access Journals (Sweden)

    HorstKessler

    2013-08-01

    Full Text Available Selective and targeted delivery of drugs to tumors is a major challenge for an effective cancer therapy and also to overcome the side effects associated with current treatments. Overexpression of various receptors on tumor cells is a characteristic structural and biochemical aspect of tumors and distinguishes them from physiologically normal cells. This abnormal feature is therefore suitable for selectively directing anticancer molecules to tumors by using ligands that can preferentially recognize such receptors. Several subtypes of integrin receptors that are crucial for cell adhesion, cell signaling, cell viability and motility have been shown to have an upregulated expression on cancer cells. Thus, ligands that recognize specific integrin subtypes represent excellent candidates to be conjugated to drugs or drug carrier systems and be targeted to tumors. In this regard, integrins recognizing the RGD cell adhesive sequence have been extensively targeted for tumor specific drug delivery. Here we review key recent examples on the presentation of RGD-based integrin ligands by means of distinct drug delivery systems, and discuss the prospects of such therapies to specifically target tumor cells.

  8. Atrial tumors in cardiac MRI

    International Nuclear Information System (INIS)

    Cardiac magnetic resonance imaging (MRI) is an important tool for the diagnosis of cardiac masses. Various cardiac tumors are predisposed to occurring in atrial structures. The aim of this review article is the description of atrial tumors and their morphological features in MRI. In general, cardiac tumors are rare: approximately 0.001-0.03% in autopsy studies. About 75% of them are benign. The most common cardiac tumor is the myxoma. They are predisposed to occur in the atria and show a characteristically strong hyperintense signal on T2-wieghted images in MRI. In other sequences a heterogeneous pattern reflects its variable histological appearance. Lipomas exhibit a signal behavior identical to fatty tissue with a typical passive movement in cine imaging. Fibroelastomas are the most common tumors of the cardiac valves. Consisting of avascular fibrous tissue, they often present with hypointense signal intensities. Thrombi attached to their surface can cause severe emboli even in small tumors. Amongst primary cardiac malignancies, sarcomas are most common and favor the atria. Secondary malignancies of the heart are far more common than primary ones (20-40 times). In case of known malignancies, approximately 10% of patients develop cardiac metastasis at the end of their disease. Lymphogenic metastases favor the pericardium, while hematogenic spread prefers the myocardium. Since they are not real atrial tumors, thrombi and anatomical structures of the atria have to be differentiated from other pathologies. (orig.)

  9. CT features of ovarian tumors

    International Nuclear Information System (INIS)

    CT findings were compared with macroscopic and histopathologic findings in 84 patients with ovarian tumors. Marginal irregularity of the tumor shown on CT exhibited marked adhesion to the greater omentum, enteron or pelvic wall at laparotomy. CT showed tumor capsules more than 10 mm in thickness in 5 of 27 patients with malignant ovarian carcinomas (18.5%) and 2 of 15 patients with endometrioid cystadenoma (13.3%). Various thickness of the capsule was seen on CT in 48.1% of the patients with malignant ovarian carcinomas and 60.0% of the patients with endometrioid cystadenoma. Diagnostic accuracy of CT for the presence of absence of solid tumors was 89.3%. Misdiagnosis was attributed to the presence of high specific gravidity of fluid contents within the tumor, partial volume phenomenon, various thickness of the capsule, coagulation, and hair mass seen in dermoid cyst. Solid tumor-like density was larger and more irregular in the group with malignant ovarian tumors than in the group with benign ones. Irregular cystic parts were seen on CT in a high incidence among the group with malignant ovarian carcinomas. Dermoid cyst was diagnosed easily by CT because CT numbers were specific to the contents of cyst. (Namekawa, K.)

  10. Cystic tumors of the pancreas

    International Nuclear Information System (INIS)

    Cystic lesions of the pancreas encompass a broad spectrum of benign, premalignant, and malignant tumors which are primarily cystic or result from cystic necroses of solid neoplasms. Because of the wide use of cross-sectional imaging techniques they are increasingly being identified in asymptomatic patients as well as in patients presenting with abdominal pain, jaundice or pancreatitis. Among these lesions, intraductal papillary mucinous neoplasms, serous cystic neoplasms and mucinous cystic neoplasms represent the majority of cases. With increasing experience with these tumors, a refinement of our understanding of their morphology and of their natural course has emerged. It is important to be familiar with the CT and MR imaging features of these lesions to differentiate these tumors and to orient the diagnosis towards benign or malignant forms. Because characterization of cystic tumors of the pancreas can sometimes be difficult due to overlapping imaging features, additional criteria such as clinical symptoms, localization, age and gender have to be taken into account. If appropriately treated, these tumors can usually be cured by resection and the decreasing risk of pancreatic surgery has led to an increasing number of resections of pancreatic tumors. The management of cystic tumors of the pancreas has not yet been standardized and the correct evaluation and subsequent management of the disease in asymptomatic patients have not been fully defined. (orig.)

  11. Statistical mechanics model of angiogenic tumor growth.

    Science.gov (United States)

    Ferreira, António Luis; Lipowska, Dorota; Lipowski, Adam

    2012-01-01

    We examine a lattice model of tumor growth where the survival of tumor cells depends on the supplied nutrients. When such a supply is random, the extinction of tumors belongs to the directed percolation universality class. However, when the supply is correlated with the distribution of tumor cells, which as we suggest might mimic the angiogenic growth, the extinction shows different critical behavior. Such a correlation affects also the morphology of the growing tumors and drastically raises tumor-survival probability. PMID:22400505

  12. Pathological advances in pediatric brain tumors

    OpenAIRE

    Wang, Li-Feng; Wang, Rui-Fen; Guan, Wen-bin; Yan, Yu

    2015-01-01

    Pediatric brain tumors are the most common solid tumors in children. Compared with brain tumors in adults, pediatric brain tumors have characteristic clinicopathological features and molecular mechanisms. The accurate diagnosis and classification of brain tumors in children is important for patients to have an individualized therapy and to improve the survival rate. With the further study of pediatric brain tumors, there are some new viewpoints on pilocytic astrocytoma (PA), ependymoma,...

  13. Malignant renal tumors in pediatrics

    International Nuclear Information System (INIS)

    Introduction: Professionals who work in pediatric oncology, we see childhood cancer as a common disease, but in fact constitutes about 2% of all cancers diagnosed worldwide. Wilms tumor accounts for 6% of all childhood tumors and presentation bilateral accounts for 4-6% of all Wilms tumors diagnosed. Theoretical Framework: In the period between the year 1994-2003 period were attended in the Pediatric Hematology-Oncology Center, a total of 29 cases of malignant renal tumors, corresponding to 86% (25 cases) to Wilms tumor or nephroblastoma tumor. The Wilms is of embryonic origin, capable of metastatic spread, (85% lungs 15% liver). Very sensitive to chemotherapy and radiotherapy, which confers high cure rates (85%); having a multidisciplinary treatment model, combining surgery, chemotherapy, and radiotherapy. The role of nursing in comprehensive cancer care child is essential in the prevention and early detection of side effects or complications. Case report: S.D. currently 10 years old. In 10/1994, at 8 months of age, was diagnosed with bilateral Wilms tumor. On admission her weight was 8200gr with abdominal circumference 50cm. Conducted pre-operative MDT and 02/1995 nephrectomy of the left kidney and right kidney lumpectomy (tumor nodule 420gr. and a 250gr.). MDT begins in 03/1995 01/1996 ending. 09/2003 with abdominal pain and vomiting, and kidney failure. 10/2003 lumpectomy biopsy (sclerotic nodule associated with maturation nephroblastoma). Currently severe renal insufficiency plan enters dialysis. Nursing process: Objectives: 1) To prepare the child and family to the side effects and possible complications of chemotherapy and / or radiotherapy 2) Prevent and minimize related complications tumor and / or treatment. Care Plan comprises four stages: A) rating and customer income. B) Implement care chemotherapy C) post-operative Care D) Implement radiation care

  14. Phyllode tumor of the breast

    International Nuclear Information System (INIS)

    The clinically variable course of phyllode tumor with its complex histological picture -ranging from benign to malignant- poses problems for the preoperative diagnosis and, in particular, the therapeutic approach. Mammograms of 99 patients with this disease, observed and treated from 1975-1989, were reviewed to determine mammographic histologic correlations useful for early diagnosis. Opacity, size, shape, margin characteristics, the presence of calcifications and radiolucent halo were determined from the mammograms. The most useful characteristics were opacity and the character of the tumor's margins. However, mammographic features alone could not distinguish phyllode tumor from fibroadenoma. (author). 12 refs.; 2 figs.; 3 tabs

  15. Postirradiation malignant salivary gland tumor

    Energy Technology Data Exchange (ETDEWEB)

    Rice, D.H.; Batsakis, J.G.; McClatchey, K.D.

    1976-11-01

    Information concerning the relationship between salivary gland tumors and prior exposure to radiation for benign conditions or by accident is slowly being gathered. As yet, no statistical confidence can be established in this relationship. Very likely, this confidence will require studies akin to those done on the problem of thyroid cancer and irradiation. Including the case reported here, 50 tumors of the salivary glands have been reported to have followed prior radiation exposure. Twenty-three of these tumors have been malignant, with the mucoepidermoid carcinoma the most frequent histological type. The latent period in salivary tissues is 20 or more years.

  16. Diagnostic evaluatuin of gastrointestinal tumors

    International Nuclear Information System (INIS)

    Prior to surgery of gastrointestinal tumors exact information about tumor localization, extent and possible infiltration in adjacent structures are important. The task for radiological and scintigraphic methods is predominantly the preoperative tumor staging. The upper (esophagus, stomach, duodenum) and the lower (colon, rectum) gastrointestinal tract should be routinely investigated by endoscopy and endosonography. CT or MRI imaging may add information about tumor extent, infiltration in adjacent structures and pathologically enlarged lymph nodes. The latter may be detected with similar or higher sensitivity by PET as well. Furthermore, with PET it is possible to differentiate a tumor recurrence from postoperative scar tissue earlier than with conventional morphological imaging techniques, for example in colorectal cancer. Liver tumors should primarily be inspected sonographically followed by an MRI scan if dignity is uncertain. The receptor scintigraphy with radioactive ligands allows to further characterize a detected tumor. Benigne liver lesions can be distinguished from malignant tumors (metastasis, hepatocellular carcinoma [HCC]) by the neogalactoalbumin-(NGA-)scintigraphy, because NGA binds exclusively to the liver galactose receptors of normally functioning hepatocytes. For the differentiation between liver metastasis and HCC insulin scintigraphy can be used, since insulin binds significantly in HCC due to an overexpression of insulin receptors in these tumors. If a malignant process is suspected, additionally CT-arterioportography may be recommended, because this newer radiological technique is capable to visualize lesions smaller than 1 cm. In such cases PET is sensitive as well and due to increased glucose metabolism even small foci can be detected with comparably high sepcificity. The method of choice for the detection of a pancreatic tumor is endoscopic sonography. In most cases the dignity of the tumor can be verified by ERCP, but sometimes it is very

  17. Soft tissue tumors - imaging methods

    International Nuclear Information System (INIS)

    Soft Tissue Tumors - Imaging Methods: Imaging methods play an important diagnostic role in soft tissue tumors concerning a preoperative evaluation of localization, size, topographic relationship, dignity, and metastatic disease. The present paper gives an overview about diagnostic methods available today such as ultrasound, thermography, roentgenographic plain films and xeroradiography, radionuclide methods, computed tomography, lymphography, angiography, and magnetic resonance imaging. Besides sonography particularly computed tomography has the most important diagnostic value in soft tissue tumors. The application of a recently developed method, the magnetic resonance imaging, cannot yet be assessed in its significance. (orig.)

  18. Liploblastoma: a rare pediatric tumor; Lipoblastoma: tumor pediatrico infrecuente

    Energy Technology Data Exchange (ETDEWEB)

    Nogues, A.; Villanua, J.; Garay, J.; Gutierrez, A. [Hospital Donostia. San Sebastian (Spain)

    2002-07-01

    Lipoblastoma is a soft tissue tumor that usually affects children under 3 years old. It typically occurs in the extremities. There have been few cases studied by MR, its interest lying in an unusual behavior exhibited by (senal) grasa. We present the case of a tumor in a 16-month-old patient along with localization and MR findings typical of this entity. (Author) 13 refs.

  19. Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy

    Science.gov (United States)

    Van de Giessen, Martijn; Schaafsma, Boudewijn E.; Charehbili, Ayoub; Smit, Vincent T. H. B. M.; Kroep, Judith R.; Lelieveldt, Boudewijn P. F.; Liefers, Gerrit-Jan; Chan, Alan; Löwik, Clemens W. G. M.; Dijkstra, Jouke; van de Velde, Cornelis J. H.; Wasser, Martin N. J. M.; Vahrmeijer, Alexander L.

    2015-02-01

    Diffuse optical spectroscopy (DOS) may be advantageous for monitoring tumor response during chemotherapy treatment, particularly in the early treatment stages. In this paper we perform a second analysis on the data of a clinical trial with 25 breast cancer patients that received neoadjuvant chemotherapy. Patients were monitored using delayed contrast enhanced MRI and additionally with diffuse optical spectroscopy at baseline, after 1 cycle of chemotherapy, halfway therapy and before surgery. In this analysis hemoglobin content between tumor tissue and healthy tissue of the same breast is compared on all four monitoring time points. Furthermore, the predictive power of the tumor-healthy tissue difference of HbO2 for non-responder prediction is assessed. The difference in HbO2 content between tumor and healthy tissue was statistically significantly higher in responding tumors than in non-responding tumors at baseline (10.88 vs -0.57 μM, P=0.014) and after one cycle of chemotherapy (6.45 vs -1.31 μM, P=0.048). Before surgery this difference had diminished. In the data of this study, classification on the HbO2 difference between tumor and healthy tissue was able to predict tumor (non-)response at baseline and after 1 cycle with an area-under-curve of 0.95 and 0.88, respectively. While this result suggests that tumor response can be predicted before chemotherapy onset, one should be very careful with interpreting these results. A larger patient population is needed to confirm this finding.

  20. Tumor cure and tumor cell survival kinetics after photoradiation treatment in vivo in two experimental mouse tumor systems

    International Nuclear Information System (INIS)

    To study the question whether tumor destruction by photoradiation therapy (PRT) in vivo is due to direct tumor cell kill or whether it is a consequence of damage to the tumor support structures, the authors have used the EMT-6 and RIF in vivo-in vitro tumor systems, which allow colony formation survival assay of tumor cells treated with PRT in vivo. The EMT-6 tumor showed no significant reduction in tumor cell clonogenicity at the completion of PRT at doses which are curative to the tumor. However, when the tumors were allowed to remain in situ for varying lengths of time (1-24 h) after PRT, tumor cell death occurred rapidly and progressively. Very similar tumor cell survival kinetics were found in RIF tumors, although cure of these tumors by PRT is rare. The pattern of tumor cell death following PRT in vivo closely matches that of tumors deprived of oxygen, implying that one of the major factors leading to tumor destruction by PRT may be the shut-down of tumor vasculature, which has been shown to be one of the initial effects of PRT

  1. Are tumor-to-tumor differences in oxygenation responsible for the heterogeneity in the response of tumors to therapy

    International Nuclear Information System (INIS)

    Individual tumors from the same transplanted tumor line often show very different responses to the same treatments, even when the tumors are implanted into similar sites in similar hosts and studied at the same time. The cause of this heterogeneity is unknown; either tumor or host factors could be responsible. Solid tumors contain large numbers of viable hypoxic cells, which are resistant to both radiotherapy and chemotherapy and limit the response of tumors to intensive treatments. To determine whether differences in the proportion of hypoxic cells in the tumors produce the observed variability in therapeutic sensitivity, the authors compared the radiation responses of normally-aerated tumors and tumors made artificially hypoxic. If large tumor-to-tumor differences in oxygenation exist, data from normally-aerated tumors should be more variable than data from hypoxic tumors (which should all be brought to uniform hypoxia and uniform radioresistance). Analysis of data from several tumor systems revealed the variability in the radiation responses of hypoxic tumors to be at least as great as that for aerobic tumors. Thus, factors other than differences in oxygenation must produce the heterogeneity in tumor radiation response

  2. Colombia en las dos fases de globalización

    Directory of Open Access Journals (Sweden)

    Salomón Kalmanovitz

    2007-12-01

    Full Text Available Los historiadores de la globalización periodizan dos grandes fases: una de 1860 a 1914, seguida de un período de desintegración de los flujos de capital, comercio y trabajadores, y otra de 1950 al presente. Este ensayo examina el comportamiento de la economía colombiana durante las dos globalizaciones. Aunque Colombia entró tardíamente a la primera fase, tuvo un comportamiento excelente, debido quizás a que partió de un punto muy bajo en la escala del desarrollo. Sus índices de comercio internacional y de participación en los flujos de capital se elevaron intensamente hasta 1930. En la segunda, el comportamiento fue relativamente mediocre; se erigieron altas barreras al comercio y a la inversión extranjera, mientras que se reprimió al sistema financiero en favor de agentes con poder político.

  3. Mobile Network DoS Attack and Detection Technology

    Directory of Open Access Journals (Sweden)

    K. Krishnamoorthy

    2013-09-01

    Full Text Available Currently, there has been a 3G mobile networks data traffic explosion due to the large increase in the number of smartphone users. Unlike a traditional wired infrastructure, 3G mobile networks have limited wireless resources and signaling procedures for complex wireless resource management and mobile network security for various abnormal and malicious traffic technologies was not ready. So Malicious or potentially malicious traffic originating from mobile malware infected smart devices can cause serious problems to the 3G mobile networks, such as DoS and scanning attack in wired networks. This paper describes the DoS security threat in the 3G mobile network and proposes a detection technology.

  4. ECONOMIA DOS RECURSOS HUMANOS: TEORIA E EVIDÊNCIAS

    Directory of Open Access Journals (Sweden)

    Andre Carraro

    2014-12-01

    Full Text Available Este trabalho tem como objetivo discutir as diversas contribuições dadas ao longo das últimas décadas à economia dos recursos humanos, uma área de crescente destaque tanto entre a comunidade acadêmica, quanto entre empresários e trabalhadores. Discutem-se os diversos tópicos que compõem as abrangentes relações empresariais, estabelecidos na literatura em quatro tópicos principais: treinamento, incentivos, organização e seleção de pessoas. É feita uma análise dos principais artigos e autores de cada uma dessas subáreas, com o intuito principal de facilitar o acesso à informação, apontar caminhos para novas pesquisas e incentivar potenciais pesquisadores.

  5. Peri-tumoral leakage during intra-tumoral convection-enhanced delivery has implications for efficacy of peri-tumoral infusion before removal of tumor.

    Science.gov (United States)

    Yang, Xiaoliang; Saito, Ryuta; Nakamura, Taigen; Zhang, Rong; Sonoda, Yukihiko; Kumabe, Toshihiro; Forsayeth, John; Bankiewicz, Krystof; Tominaga, Teiji

    2016-03-01

    In cases of malignant brain tumors, infiltrating tumor cells that exist at the tumor-surrounding brain tissue always escape from cytoreductive surgery and, protected by blood-brain barrier (BBB), survive the adjuvant chemoradiotherapy, eventually leading to tumor recurrence. Local interstitial delivery of chemotherapeutic agents is a promising strategy to target these cells. During our effort to develop effective drug delivery methods by intra-tumoral infusion of chemotherapeutic agents, we found consistent pattern of leakage from the tumor. Here we describe our findings and propose promising strategy to cover the brain tissue surrounding the tumor with therapeutic agents by means of convection-enhanced delivery. First, the intracranial tumor isograft model was used to define patterns of leakage from tumor mass after intra-tumoral infusion of the chemotherapeutic agents. Liposomal doxorubicin, although first distributed inside the tumor, distributed diffusely into the surrounding normal brain once the leakage happen. Trypan blue dye was used to evaluate the distribution pattern of peri-tumoral infusions. When infused intra- or peri-tumorally, infusates distributed robustly into the tumor border. Subsequently, volume of distributions with different infusion scheduling; including intra-tumoral infusion, peri-tumoral infusion after tumor resection, peri-tumoral infusion without tumor removal with or without systemic infusion of steroids, were compared with Evans-blue dye. Peri-tumoral infusion without tumor removal resulted in maximum volume of distribution. Prior use of steroids further increased the volume of distribution. Local interstitial drug delivery targeting tumor surrounding brain tissue before tumor removal should be more effective when targeting the invading cells. PMID:24865286

  6. Dos nuevas especies de colostethus (amphibia, dendrobatidae) de colombia

    OpenAIRE

    Rivero, Juan A.; Serna, Marco A.

    2012-01-01

    Hasta el momento de escribirse este trabajo se conocían 28 especies deColostethus en Colombia, pero cinco de estas, mencionadas en el trabajo detesis de S. R. EDWARS (1974), todavía no han sido descritas. Las dos especiesque se describen aqui han sido examinadas por W. DUELLMAN, del Museo deHistoria Natural de la Universidad de Kansas (en donde esta depositado elmaterial de EDWARDS), quien ha certificado que no se trata de ninguna desus especies.

  7. Dos nuevos algoritmos de cifrado autenticado: Silver y CPFB

    OpenAIRE

    Montes, Alfredo Miguel; Penazzi, Daniel

    2014-01-01

    El presente trabajo resume el proceso de diseño de dos algoritmos de cifrado autenticado, Silver y CPFB, que participan en la competencia CAESAR para la selección de algoritmos de cifrado autenticado. Silver es un algoritmo de cifrado basado en AES-128, mientras que CPFB es un modo de operación. Ambos basan su seguridad en la presunción de que AES es indistinguible de un random oracle.

  8. Entre combos e enigmas: a complexidade da narrativa dos games

    Directory of Open Access Journals (Sweden)

    Pinheiro, Cristiano Max Pereira

    2005-01-01

    Full Text Available O presente estudo aborda o universo dos games e, como uma forma de realizar uma investigação completa do assunto, invade também questões referentes ao cinema, à televisão, à literatura, aos quadrinhos e à música. Devido à extrema diversidade do formato aqui estudado, optou-se por focalizar a análise em dois conceitos fundamentais: narrativa e interatividade.

  9. Wascyli Simões dos Anjos: metodologias EMUFRN

    OpenAIRE

    Gouveia, Rodrigo Borges Lima

    2014-01-01

    Este estudo está voltado para as metodologias utilizadas no ensino da flauta, desenvolvidas pelo professor Wascyli Simões dos Anjos na EMUFRN. Adotou-se como pressuposto ultrapassar a ideia simplesmente metodológica. Desta forma, a metodologia de ensino da flauta transversal, concretizada pelo professor Wascyli, é tratada como um ensino humanista e humanizado, relacionado a uma racionalidade social onde estão envolvidos comportamentos, valores e saberes. Para tanto, buscou-se investigar os as...

  10. Determination of the stability classes in Angra dos Reis

    International Nuclear Information System (INIS)

    The applicability of the methods for the calculation of atmospheric dispersion used in Angra dos Reis, (site of Angra I - reactor) is discussed. A review is made of the main meteorological parameters indicating turbulence, as well as of the methods presently em ployed for doing dispersion estimates. The turbulence indicator measured in Angra dos Reis and their utilization in the categorization of the stability conditions are discussed. The methods of the rate of vertical temperature variation and the fluctuation of the wind direction to calculate the concentration in the air, are used. The correlations existing between these two methods and their temporal and spacial variation are analysed. The analysis of one-year data allows the conclusion, that, due to the low wind velocity; in Angra dos Reis the fluctuation method is a good indicator of horizontal dispersion, but it does not allow the Knowledge of vertical stability which is better determined by the vertical gradient of temperature. Due to the local condition between the mountains and the sea, only experiments on atmospheric diffusion may indicate the better method for the calculation of local dispersion. (E.G.)

  11. Evaluación y programas de intervención psicoeducativa en niños con tumores en el cerebelo

    OpenAIRE

    Grau Rubio, Claudia; Fortes del Valle, M. Carmen

    2003-01-01

    Se describen las secuelas neurológicas en niños diagnosticados de un tumor en el cerebelo y se ofrecen los resultados de la evaluación de 39 niños, con tumor en el cerebelo, tratados en la Unidad de Oncología Pediátrica del Hospital Infantil “La Fe” de Valencia. Asimismo, se compara la evaluación de secuelas de dos niños de educación infantil afectados de un tumor en el cerebelo: Yolanda (meduloblastoma, PNET) y Santiago (astrocitoma cerebeloso), y se describen las áreas en las que es acon...

  12. Tumores ósseos benignos e lesões ósseas Pseudotumorais: tratamento atual e novas tendências Benign bone tumors and tumor-like bone lesions: treatment update and new trends

    OpenAIRE

    José Marcos Nogueira Drumond

    2009-01-01

    O tratamento dos tumores ósseos benignos (TOB) e lesões ósseas pseudotumorais (LOP) tem visto surgir novos medicamentos, como os bisfosfonatos de uso intravenoso, que têm mostrado bons resultados no controle das lesões da displasia fibrosa. O cisto ósseo aneurismático tem sido tratado com agentes esclerosantes com sucesso. Tratamentos adjuvantes permitem a realização de cirurgias que preservam a articulação e a função, com baixas taxas de recidiva. Têm sido mais utilizados o cimento ósseo (PM...

  13. Tumores benignos produtores de osso na coluna: estudo de 30 casos Tumores benignos productores de hueso en la columna: estudio de 30 casos Benign spine bone tumors: case series of 30 patients

    OpenAIRE

    Osmar Avanzi; Robert Meves; Maria Fernanda Silber Caffaro; José Moussa Chalouhi

    2009-01-01

    OBJETIVO: o osteoma osteoide e o osteoblastoma são tumores benignos do osso incomuns. Diante da raridade dessas neoplasias e de literatura nacional escassa, em especial no que tange à coluna, realizou-se um estudo retrospectivo com a experiência adquirida no trato desses pacientes por 27 anos, obtendo uma expressiva série de casos para descrição dos resultados do tratamento. MÉTODOS: avaliação de prontuários e exames laboratoriais de 30 pacientes, com um seguimento médio de 47 meses, tratados...

  14. Radiological diagnostics of skeletal tumors; Radiologische Diagnostik von Knochentumoren

    Energy Technology Data Exchange (ETDEWEB)

    Uhl, M. [Universitaetsklinikum Freiburg (Germany). Kinderradiologie; Herget, G.W. [Universitaetsklinikum Freiburg (Germany). Dept. Orthopaedie und Traumatologie

    2008-07-01

    The book contains contributions concerning the following topics: 1. introduction and fundamentals: WHO classification of bone tumors, imaging diagnostics and their function; localization, typical clinical and radiological criteria, TNM classification and status classification, invasive tumor diagnostics; 2. specific tumor diagnostics: chondrogenic bone tumors, osseous tumors, connective tissue bony tumors, osteoclastoma, osteomyelogenic bone tumors, vascular bone tumors, neurogenic bone tumors, chordoma; adamantinoma of the long tubular bone; tumor-like lesions, bony metastases, bone granulomas, differential diagnostics: tumor-like lesions.

  15. Infantile pericardial round cell tumor

    International Nuclear Information System (INIS)

    Cardiac malignancies presenting in infancy are rare. Desmoplastic small round cell tumor (DSRCT) is a rare occurrence in this age group. No case of intrapericardial DSRCT has been reported in the literature in infants

  16. Tumor Acidity as Evolutionary Spite

    International Nuclear Information System (INIS)

    Most cancer cells shift their metabolic pathway from a metabolism reflecting the Pasteur-effect into one reflecting the Warburg-effect. This shift creates an acidic microenvironment around the tumor and becomes the driving force for a positive carcinogenesis feedback loop. As a consequence of tumor acidity, the tumor microenvironment encourages a selection of certain cell phenotypes that are able to survive in this caustic environment to the detriment of other cell types. This selection can be described by a process which can be modeled upon spite: the tumor cells reduce their own fitness by making an acidic environment, but this reduces the fitness of their competitors to an even greater extent. Moreover, the environment is an important dimension that further drives this spite process. Thus, diminishing the selective environment most probably interferes with the spite process. Such interference has been recently utilized in cancer treatment

  17. Stages of Gastrointestinal Carcinoid Tumors

    Science.gov (United States)

    ... carcinoid tumors include the following: Having a family history of multiple endocrine neoplasia type 1 (MEN1) syndrome or neurofibromatosis type 1 (NF1) syndrome . Having certain conditions that affect the stomach's ...

  18. Drugs Approved for Wilms Tumor

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Wilms tumor and other childhood kidney cancers. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  19. [Classification of primary bone tumors].

    Science.gov (United States)

    Dominok, G W; Frege, J

    1986-01-01

    An expanded classification for bone tumors is presented based on the well known international classification as well as earlier systems. The current status and future trends in this area are discussed. PMID:3461626

  20. Tratamento endócrino dos meningiomas: uma revisão

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Casulari Roxo Da Motta

    1995-06-01

    Full Text Available Os meningiomas são tumores benignos do sitema nervoso central. Apresentam altas taxas de recidiva e muitas vezes são considerados inoperáveis, como quando se localizam em local de difícil acesso cirúrgico ou quando englobam estruturas nobres do cérebro. Existem evidências clínicas, epidemiológicas, bioquímicas e de experimentos "in vitro" de que seu crescimento sofre influência do meio hormonal esteróideo. Vários ensaios terapêuticos têm explorado estas características do meningioma através do uso de substâncias que interferem na ação destes esteróides: RU486 (antiprogestínico e antiglicocorticóide, acetato de medroxiprogesterona (antiprogestínico, gestrinona (antiestrogênico e antiprogestínico, tamoxifen (antiestrogênico e buserelin (superagonista do LHRH, além do octreotide (análogo da somatostatina e a bromocriptina (agonista dopaminérgico. Outros medicamentos possuem potencial para o tratamento dos meningiomas: aminoglutetimina, suramin e trapidil. Nesta revisão, analizamos a literatura sobre esses aspectos.