WorldWideScience

Sample records for av langtransporterte luftforurensninger

  1. Effects of long-range transported pollutants on vegetation in boreal coniferous forests: Results from an five year investigation in the Solholmfjell area, Gjerstad, Aust-Agder; Effekter av langtransporterte luftforurensninger i boreal barskog: resultater av fem aars undersoekelser i Solhomfjell-omraadet, Gjerstad, Aust-Agder

    Energy Technology Data Exchange (ETDEWEB)

    Oekland, R.H.

    1996-01-01

    The conference paper relates to a project on investigating the effects of long-range transported pollutants in Norway. The paper gives a brief description of the more important results obtained in the project. The aim of the project was to investigate the pollution load in vegetation, soils and trees in Norwegian forest areas of the coniferous type. The project included the collection of samples from 200 test areas in a period of five years. 11 refs.

  2. Monitoring of long range transported pollutants. Annual report for 1997; Overvaaking av langtransportert forurenset luft og nedboer. Atmosfaerisk tilfoersel, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Luekewille, A.; Manoe, S.; Toerseth, K

    1998-05-01

    The report includes the 1997 monitoring results from the rural air and precipitation chemistry network in Norway. In 1997, main components in precipitation were measured at 33 sites. Trace elements were determined at 14 sites, air concentrations of sulphur and nitrogen compounds at 13 sites and ozone concentrations at 14 sites. An overview of the measurement programme is given in appendix B2. The highest mean volume weighted concentrations of sulphate, nitrate, ammonium and strong acid in precipitation were found along the southern Norwegian coast. The lowest values were measured in the central and northern parts of Norway. In almost all parts of the country the mean pollutant concentrations in precipitation were generally lower in 1997 compared to 1996. At most places in Norway pollutant deposition was generally the lowest measured so far. The annual mean concentrations of sulphate and strong acid in precipitation have been decreasing since the end of the 1970's. Since 1980 the content of sulphate has decreased by about 40-55% in southern Norway and by about 50-60% in northern Norway. The observed reductions in concentration levels are in agreement with reported downwards trends in pollutant emissions in Europe. There is no significant decrease in nitrogen compounds in precipitation. Sea salts deposited along the western coast was measured. The highest content of particulate sulphate and of nitrogen components in air and precipitation were measured in southern Norway. Due to emissions from nickel smelters in Russia the mean concentrations of sulphur dioxide were highest in Finnmark. The annual mean air concentrations of particulate sulphate have generally decreased by 45 to 60% compared to those measured in 1980. At Ny-Aalesund, annual mean concentrations of sulphur dioxide and sulphate have decreased by 58% and 54%, respectively. Since the late 1970's, the mean concentrations have shown similar developments in all parts of Norway. Due to emission reductions in Europe the values strongly decreased from 1988 to 1997. In all counties except Finnmark, dry deposition of sulphur compounds in 1997 was assessed to be 5-17% of the total deposition during winter and 19-41% during the growing season. Generally the contribution of dry deposition to total deposition was higher for nitrogen than for sulphur compounds. The largest annual mean concentrations of lead, cadmium and zinc in precipitation were measured in southern Norway. Then concentrations decreased by about 60-80% over the period 1978 to 1997. Due to emissions in Russia the levels of arsenic, copper, nickel and cobalt were relatively high in Soer-Varanger. Ozone concentrations vary significantly over the year with the highest monthly averages in March and April. In 1997 concentration levels frequently exceeded the recommended air quality guidelines. The air quality guideline given by Norwegian Pollution Control Authority (Statens forurensningstilsyn) for protection of human health (100 microgram/m{sub 3} as hourly mean) was exceeded at all sites. Three sites experienced hourly average values above the ECE critical level for protection of vegetation of 140 microgram/m{sub 3}. The critical level of 50 microgram/m{sub 3} as mean value during the growing season was exceeded at all sites. Similarly was the critical level of 60 microgram/m{sub 3} as mean value during the growing season exceeded at all sites. The critical level for accumulated ozone exposure above the threshold of 80 microgram,/m{sub 3} (40 ppb), (termed AOT40) was for crops exceeded at eight sites. The critical level for forests was not exceeded at any site. There was a significant reduction in the levels of mercury in air during the period 1992 to 1997. Concentration of lead, cadmium and zinc increased over the same period. This is opposite to the trend observed in precipitation chemistry and may b caused by an increased influence of emissions in Eastern Europe. The air concentration of alpha-hexachlorocyclohexane (alpha-HCH) in Ny-Aalesund has decreased since the early 1980's, reflecting the reduced application of the technical mixture of this insecticide. The concentration of HCH at Lista is generally about a factor of two higher than the levels found in Ny-Aalesund.

  3. Dwivedi, AV

    African Journals Online (AJOL)

    Dwivedi, AV. Vol 3, No 2 (2014) - Articles Linguistic realities in Kenya: A preliminary survey. Abstract PDF · Vol 3, No 2 (2014) - Articles Note: Contributors to this Issue Abstract PDF. ISSN: 2026-6596. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  4. Effects of long-range transported acidification on the bio-diversity in terrestrial ecosystems; Effekter av langtransporterte forsuringer paa biodiversitet i terrestriske oekosystemer

    Energy Technology Data Exchange (ETDEWEB)

    Hoeiland, K. [Oslo Univ. (Norway)

    1996-01-01

    The conference paper deals with the environmental effects of long-range transported pollutants on the biodiversity in the terrestrial ecosystems. The paper discusses different chemical substances existing in the atmosphere and their influence on vegetation together with the effects on biodiversity from acidification. 4 refs.

  5. Monitoring of long range transported pollutants. Annual report for 1997[Pesticide and PCB measurements]; Overvaaking av langtransportert forurenset luft og nedboer. Atmosfaerisk tilfoersel, 1997. Vedlegg

    Energy Technology Data Exchange (ETDEWEB)

    Luekewille, A.; Manoe, S.; Toerseth, K

    1998-05-01

    Because of an error the pesticide and PCB results from Ny-Aalesund were missing in the data appendices of report No. 736/98. These data are included in this appendix, which is a part of report No. 736/98.

  6. Monitoring of long-range transported air pollutants. Annual report for 1995; Overvaaking av langtransportert forurenset luft og nedboer. Atmosfaerisk tilfoersel, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Toerseth, K.

    1996-06-01

    Air and precipitation chemistry is determined though various monitoring programmes at several sites located in the rural areas of Norway. This report describes the results for 1995, and these are compared to the previous years. 52 refs., 32 figs., 80 tabs.

  7. Monitoring of long-range transported air pollutants, Annual report for 1996; Overvaaking av langtransportert forurenset luft og nedboer. Atmosfaerisk tilfoersel, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Toerseth, K.; Manoe, S.

    1997-12-31

    This report describes the results from the rural air- and precipitation chemistry network in Norway. In 1996, main components in precipitation were measured at 32 sites and trace elements were determined at 13 sites. The concentrations of sulphur and nitrogen compounds in air were determined at 12 sites, and concentrations of ozone at 15 sites. The highest mean concentrations of sulphate, nitrate, ammonium and strong acid in precipitation occurred along the southern coast. Low values were found from Moere og Romsdal to Troms counties. The largest wet deposition of sulphate, nitrogen components and strong acid occurred along the coast of the southernmost tip of the country. All over the country the mean concentrations of sulphate, nitrate, ammonium and strong acid in precipitation had in general increased from 1995 to 1996. Because of small annual precipitation amounts the wet depositions were the lowest measured so far at most places in Norway. The highest content of particulate sulphate and of nitrogen components in air and in precipitation were measured in Southern Norway. The mean concentrations of sulphur dioxide were highest in Finnmark due to the nickel smelters in Russia. The largest annual mean concentrations of lead, cadmium and zinc in precipitation were measured in Southern Norway. Mercury in air decreased from 1992 to 1996 while the concentrations of lead, cadmium and zinc increased. This is opposite to the trend observed in precipitation chemistry and is probably due to emissions in Eastern Europe. 47 refs., 34 figs., 37 tabs.

  8. Monitoring of long-range transported air pollutants, Annual report for 2011; Overvaaking av langtransportert forurenset luft og nedboer. Atmosfaeriske tilfoersler, 2011

    Energy Technology Data Exchange (ETDEWEB)

    Aas, Wenche; Solberg, Sverre; Manoe, Stein; Yttri, Karl Espen

    2012-07-01

    This report presents the 2011 monitoring results from the rural air- and precipitation chemistry monitoring network in Norway. In 2011, main components in precipitation were measured at 15 sites. Trace elements were determined at four sites. Air concentrations of sulphur and nitrogen compounds were measured at six sites, and ozone concentrations at eight sites. Persistent organic pollutants and heavy metals in air are determined at three sites. Measurements of PM10 and PM2.5 mass are also determined at three sites, including measurements of organic and elemental carbon (OC and EC). An overview of the measurement programme is given in Appendix B2. (Author)

  9. AVS on satellite

    Science.gov (United States)

    Zhao, Haiwu; Wang, Guozhong; Hou, Gang

    2005-07-01

    AVS is a new digital audio-video coding standard established by China. AVS will be used in digital TV broadcasting and next general optical disk. AVS adopted many digital audio-video coding techniques developed by Chinese company and universities in recent years, it has very low complexity compared to H.264, and AVS will charge very low royalty fee through one-step license including all AVS tools. So AVS is a good and competitive candidate for Chinese DTV and next generation optical disk. In addition, Chinese government has published a plan for satellite TV signal directly to home(DTH) and a telecommunication satellite named as SINO 2 will be launched in 2006. AVS will be also one of the best hopeful candidates of audio-video coding standard on satellite signal transmission.

  10. Utskrift av tredimensionell arkitekturmodell

    OpenAIRE

    Nylund, Johnny

    2015-01-01

    I examensarbetet behandlas modellering av hus anpassade för 3D-skrivning. Uppdragsgivare har varit Purmia Grön, ett företag i Pedersöre som har byggnadsplanering och 3D-modellering som huvudsakliga affärsområde. Målet med examensarbetet var att skapa en modell av ett hus som skulle lämpa sig för 3D-skrivning och inkorporera olika visuella designaspekter. 3D-skrivning är en tillverkningsprocess där ett fysiskt objekt skapas från en digital modell. Metoden har tidigare använts främst av stö...

  11. Skyggedom av enkepensjonsdommen

    DEFF Research Database (Denmark)

    Rognlien, Ida Gundersby

    2014-01-01

    Masteroppgaven undersøker om bortfall av ektefellepensjon ved lovendring med tilbakevirkende kraft er i strid med retten til eiendom etter EMK TP 1 art 1. Skyggedommetoden/ Feminist Judgments -metoden brukes for å gjenskrive enkepensjonsdommen Rt.2006.262 i et feministisk perspektiv. Da mannen døde.......1975.220. I spørsmålet om inngrepet er proporsjonalt ble vektlagt at det ikke foreligger en transparent avveining av de relevante interessene. Videre er hensynene bak og behovene for den opprinnelige ektefellepensjonen fortsatt tilstede, og de er ikke tilstrekkelig avveid mot formålene med inngrepet...

  12. Forenkling av tekniske systemer

    DEFF Research Database (Denmark)

    Førland-Larsen, Arne; Bramslev, Katharina; Halderaker, Ingrid

    De fleste moderne kontorbygg har omfattende tekniske installasjoner. Mange byggeiere opplever at dagens kompliserte tekniske anlegg ikke fungerer som de skal. De ender med å få reklamasjoner, høyt energiforbruk og klager på inneklima. Kan en kraftig forenkling av ventilasjons-, oppvarmings- og...

  13. En av gutta

    DEFF Research Database (Denmark)

    Neumann, Cecilie Basberg; Rysst, Mari; Bjerck, Mari

    2012-01-01

    Hvilken betydning har kjønn og klær for kvinner som arbeider i mannsdominerte arbeiderklasseyrker? Forfatterne av denne artikkelen finner at kvinnene må nedtone sitt kjønn og sin seksualitet gjennom å dekke til kroppen, i klær laget for menn, for å signalisere at de er på jobb for å arbeide. Hvor...

  14. Invigning av Orgel Acusticum

    OpenAIRE

    Ericsson, Hans-Ola; Weman Ericsson, Lena; Hannus, Anders

    2012-01-01

    Invigning av Orgel Acusticum, Studio Acusticum, konsertsalenHans-Ola Ericsson, orgel; Lena Weman, traversflöjt; Anders Hannus, klangregi; Birgitta Svendén, konferencièreOlivier Messiaen 1908-1992Apparition de l'Église éternelle (1932)Hans-Ola Ericsson f. 1958Nytt verk (2012) för förstärkt traversflöjt och orgelJohann Sebastian Bach 1685-1750Ich ruf zu dir, Herr Jesu Christ (BWV 639) ur OrgelbüchleinHans-Ola EricssonPostludium - "Spikar" ur orgelmässan "De fyra varelsernas Amen" (1999-2000) fö...

  15. Summer Student Report - AV Workflow

    CERN Document Server

    Abramson, Jessie

    2014-01-01

    The AV Workflow is web application which allows cern users to publish, update and delete videos from cds. During my summer internship I implemented the backend of the new version of the AV Worklow in python using the django framework.

  16. AV dissociation, an inevitable response.

    Science.gov (United States)

    Wang, Kyuhyun; Benditt, David G

    2011-07-01

    The independent activation of the atria and ventricles, AV dissociation, is a common phenomenon that occurs during a wide variety of electrophysiologic circumstances. The clinical significance of AV dissociation is often misunderstood. This article examines the basis and clinical implications of AV dissociation. AV dissociation is often an obligatory, secondary phenomenon, and should not be construed as the primary disorder; it may be due to either the AV conduction system being completely blocked (3° AV block) or the P wave and the QRS complex being generated from separate sources (usually, the AV junction or ventricle) but occurring close together during the physiologic refractory period of each other. The latter may happen in junctional or ventricular arrhythmias including escape or accelerated rhythm, tachycardia, or premature beats. The crucial clinical point is not the AV dissociation itself, but that an underlying triggering primary disorder is present and should be identified. ©2011, Wiley Periodicals, Inc.

  17. Dynamisk Analys av scrollkompressorn

    OpenAIRE

    Laso Plaza, Elena

    2007-01-01

    Det svenska företaget Thermia använder scrollkompressorer från det amerikanska bolaget Copeland i sina värmepumpsystem. Trots den betydande ljudminskning som scrollkompressorer ger jämfört med andra kompressorer är ljudtrycksnivån fortfarande 56 dBA. Den här ljudtrycksnivån är inte tillräckligt låg om man vill placera systemet i köket. Företaget önskar minska hela systemets ljudtrycksnivå. Rapporten innehåller en dynamisk analys av de olika möjliga ljudkällorna i kompressorn. Den innehåller d...

  18. Teratogene effekter av antiepileptika

    Directory of Open Access Journals (Sweden)

    Bernt A. Engelsen

    2009-10-01

    Full Text Available  SAMMENDRAGCa. 1 av 200 gravide har epilepsi. Gravide med epilepsi har økt risiko for visse obstetriske komplikasjonerog for å føde barn med medfødte misdannelser. Risikoen for misdannelser synes koblet til bruk avantiepileptika under svangerskapet, og ikke til selve epilepsien. Alle typer misdannelser er økt, men leppeganespalteog nevralrørsdefekter utgjør særlig viktige misdannelser. Årsakene til misdannelsene er multifaktorielle.Bruk av antiepileptika i monoterapi kan sies å gi en individuell risiko for større misdannelser påca. 4-6%. Karbamazepin og natriumvalproat gir hhv. 0,5-1% og 2-3% risiko for nevralrørsdefekt. Samletrisiko for større og mindre anomalier inkludert dysmorfe ansiktstrekk synes ikke å overstige 10%. ENGLISH SUMMARYEngelsen BA. Teratogenic effects of antiepileptic drugs. Nor J Epidemiol 1997; 7 (1: 23-28.Approximately 1 in 200 pregnant women have epilepsy, and 1 in 250 births are to children of mothers whouse antiepleptic drugs (AED. Pregnant women with epilepsy have increased risk for certain obstetricalcomplications, and for giving birth to children with congenital malformations. The increased risk forcongenital malformations seems connected to the use of AED, not to the epileptic syndromes. The etiologyof congenital malformations are multifactorial. Use of AED in monotherapy is associated with anindividual risk of giving birth to a child with a major malformation of 4-6%. The specific risk of spinabifida is 0,5 to 1% for carbamazepine and 2-3% for sodium valproate.

  19. Helseeffekter av byluftpartikler

    Directory of Open Access Journals (Sweden)

    Magne Refsnes

    2009-10-01

    Full Text Available Svevestøv i byluft består av forbrenningspartikler og mineralpartikler med svært forskjellige størrelser og kjemiske egenskaper. Svevestøvet kan deles inn i størrelsesfraksjoner som PMAmbient particulate matter (PM comprises particles from different combustion processes and a variety of mineral particles. The particles vary widely in size distribution and chemical/physical characteristics. PM is often divided into size fractions with different aerodynamic diameters: PM10 (PM ! 10 mm, PM2.5 (PM ! 2.5 mm and PM0.1 (PM ! 0.1 mm. Recent population studies have found an association between an increase in mortality and morbidity due to lung and/or cardiovascular disease and short-term increases in PM. The relative risk (RR was approximately 1.005 for an increase in 10 mg/m3 PM10, without an observed threshold even at concentrations below 10 mg/m3. Chronic exposure has been investigated to a lesser extent, but longterm exposure to PM2.5 has been found to be associated with an approximately 10-fold greater increase in RR than short-term exposures. Experimental studies with volunteers in chamber and field studies show mild lung or cardiovascular responses at concentrations of ambient particles (PM2.5/PM10: 100-200 mg/m3 that may occur during episodes of air pollution. Animal studies at higher concentrations have shown stronger responses. The experimental studies support the epidemiological evidence for an adverse health effect of PM. Both population- and experimental studies indicate the existence of vulnerable individuals. At low to average ambient concentrations there seems to exist a discrepancy between the results of population- and experimental studies that might be due to the absence of the most vulnerable individuals in the experimental studies. Together with cell culture experiments, human and animal studies indicate the importance of physical and chemical properties of the particles (size, content of metals, organics, endotoxins, etc. for

  20. "AV nodal" reentry: Part II: AV nodal, AV junctional, or atrionodal reentry?

    NARCIS (Netherlands)

    McGuire, M. A.; Janse, M. J.; Ross, D. L.

    1993-01-01

    The classical model of "atrioventricular (AV) nodal" reentrant tachycardia suggests that the reentrant circuit is entirely within the compact AV node and that AV nodal tissue is present proximal and distal to the circuit. Recent evidence from mapping studies and from examination of the effects of

  1. Læring av erfaring?

    DEFF Research Database (Denmark)

    Ramvi, Ellen

    Hva skal til for å lære av erfaring? Denne avhandlingen er en empirisk baseret undersøkelse av ungdosmskolelæreres muligheter og betingelser for å "lære av erfaring" i den særlige betydning av begrepet  W. Bion gir i sin psykoanalytiske teori. Undersøgelsen baserer seg på et feltarbeid som strekk...... nydefinering av lærerprofesjonalitet, må lærerne gå til kjernen av problemet, nemlig den sårbare lærer-elev relasjonen. Kun da kan det sosiale forsvarssystemet i skolen brytes ned, og den enkelte lærer kan gies rom til å lære av erfaring....

  2. Lokalisering av arbeidsplasser og boliger

    DEFF Research Database (Denmark)

    Næss, Petter

    2011-01-01

    En miljømessig effektiv lokalisering av arbeidsplasser og boliger sikter mot å begrense - og helst redusere - biltrafikk og miljøproblemer knyttet til bytransport, sammenliknet med alternative lokaliseringer. En effektiv transportmessig lokalisering kan også bidra til å redusere tap av verdifulle...... arealer (f eks jordbruksareal eller natur- og friluftsområder) utenfor dagens tettstedsgrense. Tiltaket må samtidig utformes slik at en kan bevare viktige bomiljøkvaliteter og så mye som mulig av de grønne arealene innenfor tettbebyggelsen....

  3. "AV nodal" reentry: Part I: "AV nodal" reentry revisited

    NARCIS (Netherlands)

    Janse, M. J.; Anderson, R. H.; McGuire, M. A.; Ho, S. Y.

    1993-01-01

    This review is the first of a two-part series of articles on "atrioventricular [AV] nodal reentry." The early clinical literature as well as the experimental studies are reviewed, and more recent morphologic data are presented, with the aim of clarifying whether the reentrant circuit is confined to

  4. Objektiv kumulasjon av voldgiftsregulerte krav

    OpenAIRE

    Jacobsen, Andreas Skjevik

    2013-01-01

    Oppgaven omhandler adgangen til objektiv kumulasjon etter tvl. § 15-1 når ett eller flere krav er regulert av voldgiftsavtale, jf. vogl. §§ 9 og 10. En voldgiftsavtale reiser flere spørsmål i tilknytning til objektiv kumulasjon for domstolene. For det første må det tas stilling til den prinsipielle stillingen til voldgiftsregulerte krav ved domstolene. For det andre reiser objektiv kumulasjon særlige tolkningsspørsmål ved tolkningen av voldgiftsavtalen. Oppgavens kjerne er dermed å redegjøre ...

  5. Regulering av termineringspriser i telebransjen

    OpenAIRE

    Lilloe-Olsen, Espen

    2010-01-01

    Denne oppgaven analyserer konkurranse mellom mobile nettverk i telebransjen. Formålet med oppgaven er å gi en samlet gjennomgang av litteraturen både om hvorfor termineringspriser burde reguleres på dagens måte basert på langsiktige merkostnader (LRIC), og på en alternativ måte kalt 'bill-and-keep'. Det vil argumenteres for at regulering av termineringspriser basert på langsiktige merkostnader vil føre til et ineffektivt høyt prisnivå, og bidra til å forsterke ...

  6. Bruk av kartleggingsresultater i forbedringsarbeid

    DEFF Research Database (Denmark)

    Nordahl, Thomas; Hansen, Line Skov

    . Barnehagen har gjerne tilgang på informasjon fra kartlegginger, men det er ikke alltid denne informasjonen blir systematisk analysert og aktivt brukt i forbedringsarbeid. Forfatterne viser hvordan slike analyser kan gjennomføres på forskjellige nivåer i den enkelte barnehage, og vektlegger viktigheten av...

  7. Bruk av RPAS til kartlegging av avdekket fjell

    OpenAIRE

    Arnesen, Jonas Gjersaas

    2014-01-01

    NORSK: Denne bacheloroppgaven omhandler Remotely Piloted Aircraft Systems (RPAS) og ønsker å finne svar på om dette er et verktøy som kan benyttes til kartlegging av avdekket fjell – ”Use of RPAS for surveying revealed rocks”. Kartlegging med RPAS har mange likhetstrekk med tradisjonell flyfotografering fra fly og helikopter, og det er flybilder som er utgangspunktet for å generere de triangulerte terrengmodellene. Resultatene fra RPAS-flygningen vil bli sammenliknet med refera...

  8. Forebygging av trykksår

    OpenAIRE

    Norderhaug, Inger Natvig; Lauvrak, Vigdis; Juvet, Lene Kristine

    2010-01-01

    NORSK: Bakgrunn En nasjonal pasientsikkerhetskampanje, med planlagt oppstart i 2011, er under forberedelse. For å støtte beslutningsprosessen rundt valg av innsatsområder og tiltak, har vi foretatt en hurtigoppsummering av kunnskapsgrunnlaget om effekt av et utvalg av tiltak for å forebygge trykksår hos pasienter i sykehjem og sykehus. Oppdrag Oppdraget ble gitt av Nasjonalt kunnskapssenter for helsetjenesten, sekretariatet for pasientsikkerhetskampanjen 2011. Hovedkonklusjoner ...

  9. PREPARATION FOR RETIREMENT - AVS SEMINAR

    CERN Multimedia

    Social Service

    2001-01-01

    The 500 or so participants in the fifth Preparation for Retirement seminar held at the end of March were unfortunately deprived of the planned session on the AVS due to the unavailability of the Director of the Caisse Cantonale Genevoise de Compensation (CCGC). We have since had formal confirmation that because of an extra workload due to important changes in the Swiss tax and social legislation and the implementation this summer of the maternity insurance in Geneva, the CCGC has suspended its participation in preparation for retirement seminars in the international organisations for the time being. Conscious of the necessity of offering a session dedicated to the AVS, it is with pleasure that we can inform you that one of our legal advisers, Mr Lorenz Stampfli, has accepted to lead this session. In order to allow for adequate preparation we have reserved the following date: Wednesday 26 September from 14.00 to 16.00 in the Main Amphitheatre The session will be open to all people already registered and any o...

  10. Kritik av den negativa uppbyggligheten

    DEFF Research Database (Denmark)

    Stjernfelt, Frederik; Thomsen, Søren Ulrik

    Under efterkrigstiden har ett märkligt fenomen fått fäste i kulturen. Ett konstverk, en handling, en utsaga bedöms inte längre efter om de är sköna, goda och sanna, utan efter om de bryter mot regler, gör uppror mot det konventionella eller angriper etablerade tänkesätt. Överskridandet av normer...... och provokationen mot inrotade uppfattningar framställs som viktigare än de positiva resultaten, avståndstagandet viktigare än ställningstagandet. Från att ha varit idéer hos ett fåtal filosofer, konstnärer och bohemer har denna negativism efterhand blivit en ideologi för den breda massan. Den...

  11. Arvelig hemokromatose - nytten av screening

    Directory of Open Access Journals (Sweden)

    Arne Åsberg

    2009-10-01

    Full Text Available Arvelig hemokromatose fører til jernopphopning i kroppen, men gir sjelden alvorlig helseskade. Nesten alle hemokromatosepasienter i vårt land er homozygote for C282Y-mutasjonen i HFE-genet. Omtrent 7 per 1000 innbyggere har denne genotypen. Alvorlig syke blir bare omkring 5-15% av homozygote menn og nesten ingen kvinner. Likevel er det holdepunkter for at screening for hemokromatose blant friske, yngre menn kan være kostnadseffektivt. Det er relativt lett å påvise om en person er disponert for sykdommen, i god tid før den bryter ut, og forebyggende behandling er billig og effektiv. Imidlertid kan vi ikke forutsi hvilke screeningpositive personer som ubehandlet får alvorlig sykdom. Et kontrollert forsøk med screening bør gjennomføresHereditary hemochromatosis – benefits of screening. Hereditary hemochromatosis leads to iron accumulation in the body; however, serious illness due to hemochromatosis is rare. In Norway, almost all patients with hemochromatosis are homozygous for the C282Ymutation in the HFE-gene, a genotype carried by about 7 per 1000 inhabitants. Serious complications are seen in only about 5-15% of homozygous men and in very few women. Nevertheless, screening young men for hemochromatosis may be cost-effective. Detecting predisposed men is relatively straightforward, and prophylactic treatment is cheap and effective. However, we can not predict, among screen-positive men, the few who untreated will become seriously ill. A controlled screening trial should be conducted.

  12. Förpackning av keramiska substrat

    OpenAIRE

    Karlsson, Jan

    2008-01-01

    Detta examensarbete handlar om forpackning av keramiska substrat. Canning ar det universella namnet pa forpackning av keramiska substrat. Keramiska substrat kan vara katalysatorer eller partikelfilter som anvands som ett efterbehandlingssystem i bensin och Diesel applikationer. Examensarbetet genomfordes hos Scania CV AB. I installationsprocessen sveps en keramisk fibermatta runt det keramiska substratet. Substratet inkapslas sedan med ett metalholje. Rapporten inleds med att beskriva olika i...

  13. Syncope and Idiopathic (Paroxysmal) AV Block.

    Science.gov (United States)

    Brignole, Michele; Deharo, Jean-Claude; Guieu, Regis

    2015-08-01

    Syncope due to idiopathic AV block is characterized by: 1) ECG documentation (usually by means of prolonged ECG monitoring) of paroxysmal complete AV block with one or multiple consecutive pauses, without P-P cycle lengthening or PR interval prolongation, not triggered by atrial or ventricular premature beats nor by rate variations; 2) long history of recurrent syncope without prodromes; 3) absence of cardiac and ECG abnormalities; 4) absence of progression to persistent forms of AV block; 5) efficacy of cardiac pacing therapy. The patients affected by idiopathic AV block have low baseline adenosine plasma level values and show an increased susceptibility to exogenous adenosine. The APL value of the patients with idiopathic AV block is much lower than patients affected by vasovagal syncope who have high adenosine values. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Reliabilitet av den norske versjonen av Timed Up and Go (TUG)

    OpenAIRE

    Botolfsen, Pernille; Helbostad, Jorunn L.

    2010-01-01

    Hensikt: Vurdere intratester-, intertester-, og test-retest reliabilitet av den norske versjonen av «Timed Up and Go» (TUG). Design: Metodestudie som benytter tverrsnittsstudie-design. Materiale og metode: Tretti personer (20 kvinner og 10 menn) over 75 år (gjennomsnitt 82,5) gjennomførte TUG tre ganger. To fysioterapeuter skåret deltagerne. For utregning av relativ reliabilitet ble intraclass correlation coefficient (ICC) anvendt, og for utregning av absolutt reliabilitet b...

  15. Situasjonsbestemt ledelse av studentgrupper i friluftsliv

    Directory of Open Access Journals (Sweden)

    Odd Lennart Vikene

    2014-05-01

    Full Text Available Artikkelen gir et praktisk eksempel på hvordan ulike studentgrupper i forbindelse med bygging av nødbivuakk i vinterfjellet opplevde min situasjonsbestemte ledelse som veileder. Teorigrunnlaget viser til situasjonsbestemte ledelsesmodeller og hva som kjennetegner god veiledning i friluftsliv. Datainnsamlingen bygger på kvantitative data fra et spørreskjema og benyttes til å analysere studentenes opplevelse av veileders ledelse ut i fra rangeringsmetoden Visuell Analog Skala (VAS. Fra samme spørreskjema var det også et åpent spørsmål som benyttes til refleksjon over studentenes opplevelse av sikkerhet i undervisningssituasjonen. Resultatene viser at studentgruppene opplevde klare ledelsesforskjeller gjennom de ulike fasene som ledelsen ble delt opp i, men at ledelsesatferden varierte lite i forhold til gruppenes erfaringsgrunnlag. Resultatene tyder på at jeg som veileder i stor grad har blitt påvirket av mine tidligere erfaringer og den potensielle risikoen som ligger ved aktiviteten. Selv om den situasjonsbestemte ledelsen varierte lite mellom de tre gruppene, viser resultatenes store standardavvik at de ulike smågruppene opplevde at ledelsen varierte. Dette tyder på at jeg som veileder til en viss grad har evnet å benytte situasjonsbestemt ledelse i praksis. På grunn av studentgruppenes relativt like oppfatning av ledelsen i de ulike fasene, viser resultatene også noe av vanskelighetene veileder har i forhold til å gjøre en korrekt vurdering av gruppens evner og erfaring i relasjon til læringssituasjonene som oppstår. Sentralt for ledelsen er likevel at studentgruppene opplevde ledelsen som betryggende, noe som gir studentene et godt grunnlag for senere opplevelser i tilknytning til vinterfriluftsliv og bygging av nødbivuakk.

  16. Uptake of AV-1451 in meningiomas.

    Science.gov (United States)

    Bruinsma, Tyler J; Johnson, Derek R; Fang, Ping; Senjem, Matthew; Josephs, Keith A; Whitwell, Jennifer L; Boeve, Bradley F; Pandey, Mukesh K; Kantarci, Kejal; Jones, David T; Vemuri, Prashanthi; Murray, Melissa; Graff-Radford, Jonathan; Schwarz, Christopher G; Knopman, David S; Petersen, Ronald C; Jack, Clifford R; Lowe, Val J

    2017-12-01

    AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer's disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword "meningioma" to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student's t test was run between background and tumor standard uptake values. Fisher's exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. We identified 12 cases of meningioma, 58% (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student's t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.

  17. Nedbrytning av utvalgte plantevernmidler i norsk jordsmonn

    OpenAIRE

    Haneborg, Mads Alexander

    2015-01-01

    Denne masteroppgaven har hatt som formål å modellere nedbrytningen av et utvalg sprøytemidler som ble testet på to norske forsøksfelt, i Stjørdal og Klepp med ulike klimatiske forhold og jordsmonn. For begge forsøksfelt ble det foretatt uttak av jordprøver over en periode på ett år fra sprøytingen, i tidsrommet fra mai 2012 til juni 2013. Jordprøvene ble analysert ved bruk av LC-MS/MS etter prøveopparbeiding med væskeekstraksjon. Intern standard metode ble benyttet til kvantifise...

  18. AVS (Application Visualization System) user's guide

    International Nuclear Information System (INIS)

    Masuko, Kenji; Kato, Katsumi; Gorai, Kazuo; Yamazaki, Kazuhiko.

    1996-03-01

    Computer and network environment for image processing has been developed and maintained under the course of establishing a distributed processing environment by the information system operating division. We introduced a server for image processing, AVS for image processing software and an animation processing system (video, frame scan converter). This report summarizes the information to use AVS and to develop and maintain computer and network environment for image processing. (author)

  19. Outcomes of AV Fistulas and AV Grafts after Interventional Stent-Graft Deployment in Haemodialysis Patients.

    Science.gov (United States)

    Schmelter, Christopher; Raab, Udo; Lazarus, Friedrich; Ruppert, Volker; Vorwerk, Dierk

    2015-08-01

    The study was designed to assess outcomes of arteriovenous (AV) accesses after interventional stent-graft deployment in haemodialysis patients. 63 haemodialysis patients with 66 AV fistulas and AV grafts were treated by interventional stent-graft deployment from 2006 to 2012 at our hospital. Data of these patients were retrospectively analysed for location of deployed stent-grafts, occurrence and location of (re-)stenosis and (re-)thrombosis. Complex stenosis was the most frequent indication for stent-graft deployment (45.5%), followed by complications of angioplasty with vessel rupture or dissection (31.8%). A high rate of procedural success was achieved (98.5%). The most frequent location of the deployed stent-graft was the draining vein (66.7%). Stent-graft deployment was more frequent in AV grafts than in AV fistulas. Primary patency was 45.5% at 6 month, 31.3% at 12 month and 19.2% at 24 month. Primary patency was significantly better for AV fistulas than for AV grafts with deployed stent-grafts. Patency of the deployed stent-graft was much better than overall AV access primary patency with deployed stent-graft. Re-stenosis with thrombosis was the most frequent indication for re-intervention. Most frequent location of re-stenosis was the draining vein (37.1%), followed by stenosis at the AV access (29.5%) and the deployed stent-graft (23.5%). Re-stenosis and re-thrombosis remain frequent in AV fistulas and AV grafts in haemodialysis patients despite stent-graft deployment. Re-stenosis of the deployed stent-graft is, only in the minority of the cases, responsible for AV access dysfunction.

  20. Outcomes of AV Fistulas and AV Grafts after Interventional Stent-Graft Deployment in Haemodialysis Patients

    Energy Technology Data Exchange (ETDEWEB)

    Schmelter, Christopher, E-mail: christopher.schmelter@klinikum-ingolstadt.de; Raab, Udo, E-mail: udo.raab@klinikum-ingolstadt.de [Klinikum Ingolstadt, Department of Diagnostic and Interventional Radiology (Germany); Lazarus, Friedrich, E-mail: friedrich.lazarus@klinikum-ingolstadt.de [Klinikum Ingolstadt, Department of Nephrology (Germany); Ruppert, Volker, E-mail: volker.ruppert@klinikum-ingolstadt.de [Klinikum Ingolstadt, Department of Vascular Surgery (Germany); Vorwerk, Dierk, E-mail: dierk.vorwerk@klinikum-ingolstadt.de [Klinikum Ingolstadt, Department of Diagnostic and Interventional Radiology (Germany)

    2015-08-15

    PurposeThe study was designed to assess outcomes of arteriovenous (AV) accesses after interventional stent-graft deployment in haemodialysis patients.Materials and Methods63 haemodialysis patients with 66 AV fistulas and AV grafts were treated by interventional stent-graft deployment from 2006 to 2012 at our hospital. Data of these patients were retrospectively analysed for location of deployed stent-grafts, occurrence and location of (re-)stenosis and (re-)thrombosis. Complex stenosis was the most frequent indication for stent-graft deployment (45.5 %), followed by complications of angioplasty with vessel rupture or dissection (31.8 %).ResultsA high rate of procedural success was achieved (98.5 %). The most frequent location of the deployed stent-graft was the draining vein (66.7 %). Stent-graft deployment was more frequent in AV grafts than in AV fistulas. Primary patency was 45.5 % at 6 month, 31.3 % at 12 month and 19.2 % at 24 month. Primary patency was significantly better for AV fistulas than for AV grafts with deployed stent-grafts. Patency of the deployed stent-graft was much better than overall AV access primary patency with deployed stent-graft. Re-stenosis with thrombosis was the most frequent indication for re-intervention. Most frequent location of re-stenosis was the draining vein (37.1 %), followed by stenosis at the AV access (29.5 %) and the deployed stent-graft (23.5 %).ConclusionRe-stenosis and re-thrombosis remain frequent in AV fistulas and AV grafts in haemodialysis patients despite stent-graft deployment. Re-stenosis of the deployed stent-graft is, only in the minority of the cases, responsible for AV access dysfunction.

  1. Strategiske beslutninger foran publikum : en spillteoretisk analyse av betingelser for utbrudd av borgerkrig

    OpenAIRE

    Meyer, Sunniva Frislid

    2006-01-01

    Borgerkrig modelleres i foreliggende litteratur enten som følge av privat informasjon om aktørenes forventede nytte av krig eller som følge av at myndighetene ikke troverdig kan forplikte seg til en fremforhandlet avtale. Eksisterende modeller overser i stor grad hvordan effekten av at myndighetene gir etter for en intern grupperings krav kan påvirke hvordan andre interne grupperinger forholder seg til myndighetene i fremtiden. Dersom myndighetene gir etter for en intern grupperings krav, kan...

  2. Praktisering av krav til rettvisende oversikt i årsberetning : en analyse av regnskapspraksis i fiskeindustrien

    OpenAIRE

    Vajenina, Larissa

    2012-01-01

    Dette er en studie av årsberetning, og videre praktisering av rettvisende oversikt i årsberetning. Studiens problemstilling: ”Hvordan blir kravene om rettvisende oversikt i årsberetning praktisert i utvalgte selskaper i Norge?” I denne studien ser jeg på praksis av rettvisende oversikt i årsberetning. Lovkravet til rettvisende oversikt i årsberetning fremgår av rskl.§ 3-3a, 2.-4.ledd. Innhold i rettvisende oversikt er grundig beskrevet under punkt 2.5 i NRS 16 Årsberetning. Reg...

  3. Veileder for kravspesifikasjon for leie av kontorarealer

    DEFF Research Database (Denmark)

    Førland-Larsen, Arne

    Investorer og leietakere blir stadig mer interessert i helse- og miljøkvaliteter. Men kunnskapen er lav hos de fleste om hva de skal etterspørre og hvordan slike kvaliteter kan dokumenteres. Meglere har en viktig rolle som formidler av kvaliteter. Grønn Byggallianse har i samarbeid med blant annet...... Norsk Eiendom, Enova og NGBC utarbeidet en mal for standard kravspesifikasjon for leie av kontorlokaler. Målet med malen er å bidra til at leietager får det produktet han trenger til riktig pris og at man unngår unødig miljøbelastning. Målet er videre at å bidra og stimulere til, at innleie....../utleie prosesser startes med en dialogbasert prosess. Standarden er tenkt som et hjelpemiddel til en systematisk gjennomgang av, og diskusjon av hvilke kvaliteter som har prioritet, høy, middel eller lav prioritet for leietaker. Resultatet av dialog og diskusjon fastlegger endelige krav til kvalitet og...

  4. Vinkelegenskapsklassificering av svetsglas : Angående utvecklingen av en conometerbaserad klassifikationsutrustning.

    OpenAIRE

    Sundell, Erik

    2016-01-01

    Denna rapport är skriven för optikgruppen på 3M Svenska ABs forsknings- och utvecklingsavdelning i Gagnef. Rapporten beskriver den driftsatta tekniken för vinkelegenskapsklassificeringar av ADFer samt den berörda fysiken. Rapporten avser att underlätta det ofullständiga arbetet av att ackreditera optikgruppens förmåga att genomföra dessa klassifikationer. Rapporten inleds med att beskriva fysiken relaterad till mätning av mänsklig ljusupplevelse. Därefter presenteras bland annat tekniken krin...

  5. Vurdering av strømforhold og partikkelspredning ved etablering av ny dypvannskai ved Rana Industriterminal

    OpenAIRE

    Staalstrøm, Andre; Kempa, Magdalena

    2015-01-01

    Det skal etableres en ny dypvannskai ved Rana Industriterminal, og i den forbindelse har NIVA gjort vurderinger av strømforhold i området og partikkelspredning i anleggsperioden. I denne rapporten er det tatt utgangspunkt i at 135 000 m³ med masse skal mudres opp. Det er videre antatt at 2 % av denne massen spres i Ranfjorden, og dette utgjør 1620 tonn tørr masse. Denne mengden tilsvarer den samme mengden partikler som kan tilføres fjorden fra Ranelva i løpet av en ukes tid, og anses ikke som...

  6. Att arbeta tillsammans - utvärdering av nytt kursupplägg av examensarbeten

    Directory of Open Access Journals (Sweden)

    Sofia Thorsson

    2015-06-01

    Full Text Available Grupphandledning av examensarbete inom geografi, med fokus på naturgeografi, vid Göteborgs Universitet infördes 2012 som ett komplement till den individuella handledningen i syfte att öka genomströmningen av studenter samt kvaliteten på arbetena. I denna artikel presenteras och utvärderas det aktuella kursupplägget. Såväl genomströmningen som kvaliteten (bearbetning och tolkning av materialet, teorianknytning, disposition och språk ökade efter införandet av grupphandledning, vilket i linje med tidigare studier visar att grupphandledning är ett bra komplement till den traditionella individuella handledningen.

  7. Digitala backspeglar - Fysisk-ergonomiska konsekvenser av arrangemang av digitala backspeglar i en lastbilshytt

    OpenAIRE

    LUNDIN, ARVID; ZAIMOVIC, NEDIM

    2016-01-01

    Backspeglar på dagens lastbilar bidrar till fordonets bränsleförbrukning på grund av det luftmotstånd som de orsakar. Detta bidrag kan minskas om de fysiska speglarna ersätts av digitala motsvarigheter, i form av kameror monterade på lastbilens utsida och bildskärmar placerade inuti lastbilshytten. Ett sådant ingrepp medför en rad möjligheter för förbättring av inte bara fordonets verkningsgrad utan även förarmiljön. Med digitala backspeglar så skulle det vara möjligt att visa stödjande grafi...

  8. Konsum av risiko-matvarer - Beskrivelse av en undersøkelse som skal kartlegge konsum av matvarer med betydning for inntaket av miljøgifter

    Directory of Open Access Journals (Sweden)

    Helle Margrete Meltzer

    2009-11-01

    Full Text Available  SAMMENDRAGI perioden 1999-2001 vil det bli gjennomført tre kostholdsundersøkelser som til sammen skal kartlegge konsum avmatvarer med betydning for inntaket av miljøgifter i Norge, fortrinnsvis kadmium, kvikksølv, PCB og dioksiner.Disse giftene finnes hovedsakelig i krabbe, flatfisk, skjell, gjedde og abbor, lever eller nyre fra vilt og viltvoksendesopp. Fordi gjennomsnittskonsumet er lavt, spørres det ikke spesifikt om disse matvarene i landsdekkende kostholdsundersøkelsersom 'Norkost'. Hensikten med studien er å kunne gi en bedre beskrivelse av eksponeringsfordelingeni befolkningen med tanke på miljøgifter. Fordelingen er antakelig skjev, dvs. et stort antall personerventes å ha et lavt inntak og noen få personer ventes å ha et relativt høyt inntak av de undersøkte stoffene. Eventuelleukjente risikogrupper vil kunne avdekkes, og det er av stor interesse å undersøke hvor stor eksponeringen i deutsatte gruppene er.Del A av undersøkelsen er landsdekkende og omfatter en postal frekvensundersøkelse til 10 000 tilfeldig valgtepersoner mellom 18 og 79 år. Del B omfatter en postal frekvensundersøkelse til 6000 tilfeldig valgte personer i sekskommuner, der tre er kystkommuner og tre er innlandskommuner. Kommunene blir valgt ut fra kjennskap til godtilgang på de aktuelle matvarene. Vi antar at der tilgangen på matvarene er god, er konsumet høyere. Del C avundersøkelsen vil omfatte høykonsumenter av aktuelle matvarer, valgt fra del B av undersøkelsen. Dette vil være endybdestudie der analyser av miljøgifter i blod, hår og urin også skal inngå.Undersøkelsen er den første i sitt slag her til lands og vi kjenner ikke til at tilsvarende studier er gjort i andreland. Hensikten med artikkelen er å gi en beskrivelse av undersøkelsen i en tidlig fase av gjennomføringen.Meltzer HM, Bergsten C, Stene LC, Stigum H, Wiborg ML, Lund-Larsen K, Alexander J. Consumption ofcontaminated foods – Description of a dietary survey

  9. En analyse knyttet til bruk av cookies.

    OpenAIRE

    Hørthe, Stine

    2012-01-01

    Cookies er små informasjonskapsler som Internettaktører legger igjen på en slutt-brukers datamaskin ved surfing på nettsider. Bruken av cookies på nettsider har fåttøkt oppmerksomhet de siste årene. I tillegg til å muliggjøre flere nyttige funksjonerfor en tjenestetilbyder, som for eksempel brukerrettet reklame og informasjonsinn-henting, har det den siste tiden blitt rettet en del kritiske spørsmål rundt bruken avcookies samt spørsmål knyttet til personvern og juridiske aspekt. Denne oppgave...

  10. Instrumentering av Bergsøysundbrua og Gjemnesundbrua

    OpenAIRE

    Dahlen, Adrian; Lystad, Tor Martin

    2013-01-01

    Gjemnessundbrua og Bergsøysundbrua på Europavei E39 i Møre og Romsdal, skal instrumenteres for identifikasjon av strukturelle og dynamiske egenskaper. Denne rapporten omhandler dokumentasjon og beskrivelse av det utførte arbeidet ved monteringen av måleutstyret. Det er også gjort analyser av de ulike konstruksjonsdelene akselerometersensorer og anemometre er montert på. Til slutt er de initielle responssignalene fra systemet behandlet, der egenfrekvenser og dempningsegenskaper til bruene blir...

  11. Betydelsen av taktil massage i omvårdnaden av dementa patienter- En systematisk litteraturstudie

    OpenAIRE

    Wetterström, Marina; Swan, Emelie

    2008-01-01

    Syftet med denna systematiska litteraturstudie var att se vilka effekter taktil massage ger hos personer med demens. Sökning av artiklar har gjorts på databaserna CINAHL, ELIN@Dalarna och PubMed där sökorden dementia, massage, nursing, older people, Therapeutic touch och touch användes i olika kombinationer. Litteraturstudien består av kvantitativa och kvalitativa artiklar. Artiklarna skulle vara vetenskapliga och inte publicerade före 1995, de skulle även svara på syfte och frågeställning. F...

  12. Upplevelser av "Employer Branding" : En kvalitativ fallstudie av anställda hos BA

    OpenAIRE

    Hermansson, Otto; Elisabeth, Mackenhauer

    2016-01-01

    Syftet med denna studie var att undersöka hur medarbetarna på BA (fiktivt namn) upplever organisationens interna Employer Branding-arbete samt att belysa de aspekter som eventuellt skiljer strategi mot upplevelse. Det gjordes ett målinriktat urval av organisation medan valet av deltagare var ett slumpmässigt urval vilket resulterade i åtta respondenter (n= 8). Studien var en kvalitativ fallstudie med ett psykologiskt angreppssätt och innehöll en ostrukturerad intervju som tillsammans m...

  13. Implementeringsforskning: vitenskap for forbedring av praksis

    Directory of Open Access Journals (Sweden)

    Signe Flottorp

    2013-11-01

    Full Text Available Medisinsk forskning har ført til store framskritt de siste tiårene. Det er investert mye mer ressurser på basalforskning og klinisk forskning enn på å utvikle og evaluere metoder for å sikre at pasientene får nytte av forskningen. Formålet med implementeringsforskning er å redusere gapet mellom forskning og praksis, ved å utvikle og evaluere tiltak som kan sikre at behandlingen som pasientene mottar er kunnskapsbasert, at den er omsorgsfull og av god kvalitet.I denne artikkelen gjør vi rede for hva implementering og implementeringsforskning er. Vi belyser historikken til denne unge vitenskapen, og illustrerer mangfoldet i de faglige tilnærmingene og begrepene som brukes om det å få forskning brukt i praksis. Det finnes en rekke teorier om endring av atferd, både på individnivå og på organisatorisk nivå. Teoriene er imidlertid i liten grad testet empirisk, særlig når det gjelder å endre atferd i helsetjenesten.Systematiske oversikter over metodisk gode studier er den beste kilden til informasjon om effekt av implementeringstiltak. The Cochrane Effective Practice and Organisation of Care Group (EPOC er en viktig kilde for slike oversikter. De systematiske oversiktene som er utarbeidet på dette feltet viser at passive dissemineringstiltak har begrenset effekt, mens mer aktive tiltak kan ha liten til moderat effekt. Det er ofte betydelig variasjon i effekt på tvers av studiene. Det er derfor viktig å få bedre kunnskap om hvilke faktorer som kan forklare slike forskjeller i effekt.Vi gir eksempler på norske implementeringsstudier, og refererer bidrag fra forskere ved Kunnskapssenteret. Implementeringsforskningen kan, hvis den lykkes, sikre pasientene bedre behandling.Flottorp S, Aakhus E. Implementation research: science for improving practice. Nor J Epidemiol 201 3; 23 (2: 187-196.ENGLISH SUMMARY Medical research has led to major advances in recent decades. More resources have been invested in basic and clinical research

  14. Design av arkitektur for evolusjonær maskinvare basert på intern rekonfigurering av FPGA

    OpenAIRE

    Senland, Geir Aarstad

    2008-01-01

    Det ble i denne oppgaven designet en arkitektur for evolusjonær maskinvare basert på intern rekonfigurering av FPGA. Til å utføre intern rekonfigurasjonen av FPGA-en ble internal configuration access port (ICAP) brukt. Programmet PlanAhead fra Xilinx ble brukt til å designe den interne rekonfigurasjonsdelen av arkitekturen. Motivasjonen for oppgaven var å introdusere fleksibilitet til et signal- og klassifikasjonssystem, ved å bruke intern rekonfigurasjon av FPGA. Klassifikasjonssystemet ...

  15. AVS user's guide on the basis of practice

    International Nuclear Information System (INIS)

    Masuko, Kenji; Kato, Katsumi; Kume, Etsuo; Fujii, Minoru.

    1997-07-01

    The special guides for the use of visualization software AVS have been developed at Japan Atomic Energy Research Institute (JAERI). The purpose of these guides is to help the AVS users understand easily the use of the one, due to the fact that it is so difficult for beginners to understand the original manuals. In this report, 'Transportation Evacuation Simulation' is taken up as an object of visualization, and the procedure of visualization and images recording by using the AVS are described. By using the AVS according to this report, a series of the procedure which are necessary for use of the AVS can be acquired. (author)

  16. Analys av nickel med ICP-MS

    OpenAIRE

    Wallman, Karin; Löfgren, Stefan; Sonesten, Lars; Demandt, Christian

    2009-01-01

    Vid en granskning av nickelhalter för perioden 1985-2007 upptäcktes ett nivåskifte i tidsserierna på flera stationer mellan 2001 och 2002. Skiftet visade sig bero på att prover innan 2002 inte korrigerades för kalciuminterferens, medan prover under åren 2002-2007 korrigerades. Syftet med denna rapport är att utreda om resultaten före 2002 i efterhand kan korrigeras för kalciuminterferensen. Från 2002 finns ett antal prover (N=347) med resultat som både är kalciumkorrigerade och som inte är de...

  17. Når kontakter betyr alt : En studie av bruken av nettverksmediet LinkedIn

    OpenAIRE

    Blaalid, Maren Hyvang

    2012-01-01

    LinkedIn er et av de mest populære sosiale mediene i Norge og tiltrekker seg stadig flere medlemmer. I denne masteroppgaven studerer jeg bruken av LinkedIn for å undersøke hva som er det særegne ved dette nettverksmediet. Jeg har utført en spørreundersøkelse blant 280 brukere for å få innsikt i hvem de er, hvorfor de bruker LinkedIn og hvordan de gjør det. Funnene fra analysen viser at brukerne kjennetegnes ved at de er selvstendige og formålsrasjonelle, som bruker LinkedIn strategisk for å n...

  18. Functional mathematical model of dual pathway AV nodal conduction.

    Science.gov (United States)

    Climent, A M; Guillem, M S; Zhang, Y; Millet, J; Mazgalev, T N

    2011-04-01

    Dual atrioventricular (AV) nodal pathway physiology is described as two different wave fronts that propagate from the atria to the His bundle: one with a longer effective refractory period [fast pathway (FP)] and a second with a shorter effective refractory period [slow pathway (SP)]. By using His electrogram alternance, we have developed a mathematical model of AV conduction that incorporates dual AV nodal pathway physiology. Experiments were performed on five rabbit atrial-AV nodal preparations to develop and test the presented model. His electrogram alternances from the inferior margin of the His bundle were used to identify fast and slow wave front propagations. The ability to predict AV conduction time and the interaction between FP and SP wave fronts have been analyzed during regular and irregular atrial rhythms (e.g., atrial fibrillation). In addition, the role of dual AV nodal pathway wave fronts in the generation of Wenckebach periodicities has been illustrated. Finally, AV node ablative modifications have been evaluated. The model accurately reproduced interactions between FP and SP during regular and irregular atrial pacing protocols. In all experiments, specificity and sensitivity higher than 85% were obtained in the prediction of the pathway responsible for conduction. It has been shown that, during atrial fibrillation, the SP ablation significantly increased the mean HH interval (204 ± 39 vs. 274 ± 50 ms, P AV node mechanisms and should be considered as a step forward in the studies of AV nodal conduction.

  19. AV nodal dual pathway electrophysiology and Wenckebach periodicity.

    Science.gov (United States)

    Zhang, Youhua; Mazgalev, Todor N

    2011-11-01

    The precise mechanism(s) governing the phenomenon of AV nodal Wenckebach periodicity is not fully elucidated. Currently 2 hypotheses, the decremental conduction and the Rosenbluethian step-delay, are most frequently used. We have provided new evidence that, in addition, dual pathway (DPW) electrophysiology is directly involved in the manifestation of AV nodal Wenckebach phenomenon. AV nodal cellular action potentials (APs) were recorded from 6 rabbit AV node preparations during standard A1A2 and incremental pacing protocols. His electrogram alternans, a validated index of DPW electrophysiology, was used to monitor fast (FP) and slow (SP) pathway conduction. The data were collected in intact AV nodes, as well as after SP ablation. In all studied hearts the Wenckebach cycle started with FP propagation, followed by transition to SP until its ultimate block. During this process complex cellular APs were observed, with decremental foot formations reflecting the fading FP and second depolarizations produced by the SP. In addition, the AV node cells exhibited a progressive loss in maximal diastolic membrane potential (MDP) due to incomplete repolarization. The pause created with the blocked Wenckebach beat was associated with restoration of MDP and reinitiation of the conduction cycle via the FP wavefront. DPW electrophysiology is dynamically involved in the development of AV nodal Wenckebach periodicity. In the intact AV node, the cycle starts with FP that is progressively weakened and then replaced by SP propagation, until block occurs. AV nodal SP modification did not eliminate Wenckebach periodicity but strongly affected its paradigm. © 2011 Wiley Periodicals, Inc.

  20. Pollen transmission of asparagus virus 2 (AV-2) may facilitate mixed infection by two AV-2 isolates in asparagus plants.

    Science.gov (United States)

    Kawamura, Ryusuke; Shimura, Hanako; Mochizuki, Tomofumi; Ohki, Satoshi T; Masuta, Chikara

    2014-09-01

    Asparagus virus 2 (AV-2) is a member of the genus Ilarvirus and thought to induce the asparagus decline syndrome. AV-2 is known to be transmitted by seed, and the possibility of pollen transmission was proposed 25 years ago but not verified. In AV-2 sequence analyses, we have unexpectedly found mixed infection by two distinct AV-2 isolates in two asparagus plants. Because mixed infections by two related viruses are normally prevented by cross protection, we suspected that pollen transmission of AV-2 is involved in mixed infection. Immunohistochemical analyses and in situ hybridization using AV-2-infected tobacco plants revealed that AV-2 was localized in the meristem and associated with pollen grains. To experimentally produce a mixed infection via pollen transmission, two Nicotiana benthamiana plants that were infected with each of two AV-2 isolates were crossed. Derived cleaved-amplified polymorphic sequence analysis identified each AV-2 isolate in the progeny seedlings, suggesting that pollen transmission could indeed result in a mixed infection, at least in N. benthamiana.

  1. Effekt av melkesyrebakteriers metabolisme på utviklingen av Escherichia coli O157:H7 i melk

    OpenAIRE

    Westblad, Anne Margrethe

    2010-01-01

    Dagens regelverk sier at all melk som omsettes skal være varmebehandlet, men åpner samtidig for salg av melkeprodukter basert på upasteurisert melk, forutsatt overholdelse av visse krav. Dermed kan småskalavirksomheter framstille melkeprodukter av upasteurisert melk hvis de skulle ønske det. Et slikt ønske er ofte begrunnet i tradisjoner og praktiske forhold. I tillegg er det flere som påstår at råmelk er sunnere enn pasteurisert melk og at råmelkas mikroflora hemmer vekst av uønskede bakteri...

  2. Farmakologisk behandling av antisosiale lidelser : en litteraturstudie av evidensgrunnlaget for famakologisk behandling av psykopati og assosierte antisosiale personlighetstrekk og atferdsmønster

    OpenAIRE

    Romberg, Sara Montes

    2016-01-01

    Bakgrunn: Psykoterapeutiske og atferdsbaserte intervensjoner har vist seg å ha liten effekt ved antisosiale lidelser. Individer med antisosiale lidelser anses derfor som en relativt behandlingsresistent pasientgruppe, hvilket tyder på et behov for utvikling av alternative behandlingstilnærminger. Med bakgrunn i dette søker følgende studie å utforske evidensgrunnlaget for farmakologiske behandling av antisosiale lidelser og trekk. Metode: Litteratursøk i databasene BIBSYS, ProQuest, Web of ...

  3. Fiskeoppdrett og verdsettelse : en analyse av resultatjustering og modeller for identifikasjon av slik aktivitet

    OpenAIRE

    Aaker, Harald

    2005-01-01

    Regnskapsinformasjon skal være relevant og pålitelig, men det vil alltid være skjønn forbundet med verdsettelsen.Usaklig skjønn omtales som resultatjustering (”Earnings management”) og regnskaps-manipulasjon. Det er store metodeproblemer innen ”earnings management” – forskningen, da den aktive tilpasningen i stor grad er skjult. I de senere år har ulike modeller for estimering av unormale tidsavgrensninger (”discretionary accruals”) dominert. Problemet er i å estimere de normale tidsavgrensni...

  4. Planretningslinjer for en differensiert forståelse av byggeforbudet i strandsonen erfart av tre kommuner

    OpenAIRE

    Alvheim, Maren

    2014-01-01

    I plan- og bygningsloven er det nå delvis videreført og innstrammet et unntak fra byggeforbudet for å ta hensyn til variasjonene mellom landets kystkommuner. Unntaket innebærer at kommunene må fastsette en ny byggegrense gjennom plan for å fravike forbudet mot bygging i strandsonen. Statlige planretningslinjer for differensiert forvaltning av strandsonen langs sjøen (SPR) er iverksatt med mål om å tydeliggjøre kommunenes adgang til å bygge i strandsonen gjennom plan. Oppgaven søker å avklare ...

  5. AV Rising: Demand, Budgets, and Circulation Are All Up.

    Science.gov (United States)

    Oder, Norman

    1998-01-01

    A survey of 486 public libraries found that audiovisual (AV) budgets have increased 53% in the last five years. Provides data on average size of AV collections; budget break downs; circulation; audiobook, video, and music CD purchases; popular authors and titles in abridged and unabridged audiobooks; and problems with audiobook, video, and music…

  6. Quantification of Tau Load Using [F-18]AV1451 PET

    NARCIS (Netherlands)

    Golla, Sandeep S. V.; Timmers, Tessa; Ossenkoppele, Rik; Groot, Colin; Verfaillie, Sander; Scheltens, Philip; van der Flier, Wiesje M.; Schwarte, Lothar; Mintun, Mark A.; Devous, Michael; Schuit, Robert C.; Windhorst, Albert D.; Lammertsma, Adriaan A.; Boellaard, Ronald; van Berckel, Bart N. M.; Yaqub, Maqsood

    2017-01-01

    The tau tracer [F-18]AV1451, also known as flortaucipir, is a promising ligand for imaging tau accumulation in Alzheimer's disease (AD). Most of the previous studies have quantified tau load using standardized uptake value ratios (SUVr) derived from a static [F-18]AV1451 scan. SUVr may, however, be

  7. Spontaneous resolution of complete atrioventricular (A-V ...

    African Journals Online (AJOL)

    Atrioventricular (A-V) disassociation describes the independent beating of the atria and ventricles of the heart. It is not synonymous with complete heart block in the sense that, A-V disassociation is a general term. Heart block describes specific conduction abnormalities that need specific cardiac intervention. This case report ...

  8. EST Table: AV398539 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV398539 NV021929 11/12/09 GO hit GO:0005622(intracellular)|GO:0008270(zinc ion bin...0769|gb|EEZ97216.1| hypothetical protein TcasGA2_TC011009 [Tribolium castaneum] AV398539 NV02 ...

  9. Cofactor requirement of HpyAV restriction endonuclease.

    Directory of Open Access Journals (Sweden)

    Siu-Hong Chan

    Full Text Available BACKGROUND: Helicobacter pylori is the etiologic agent of common gastritis and a risk factor for gastric cancer. It is also one of the richest sources of Type II restriction-modification (R-M systems in microorganisms. PRINCIPAL FINDINGS: We have cloned, expressed and purified a new restriction endonuclease HpyAV from H. pylori strain 26695. We determined the HpyAV DNA recognition sequence and cleavage site as CCTTC 6/5. In addition, we found that HpyAV has a unique metal ion requirement: its cleavage activity is higher with transition metal ions than in Mg(++. The special metal ion requirement of HpyAV can be attributed to the presence of a HNH catalytic site similar to ColE9 nuclease instead of the canonical PD-X-D/EXK catalytic site found in many other REases. Site-directed mutagenesis was carried out to verify the catalytic residues of HpyAV. Mutation of the conserved metal-binding Asn311 and His320 to alanine eliminated cleavage activity. HpyAV variant H295A displayed approximately 1% of wt activity. CONCLUSIONS/SIGNIFICANCE: Some HNH-type endonucleases have unique metal ion cofactor requirement for optimal activities. Homology modeling and site-directed mutagenesis confirmed that HpyAV is a member of the HNH nuclease family. The identification of catalytic residues in HpyAV paved the way for further engineering of the metal binding site. A survey of sequenced microbial genomes uncovered 10 putative R-M systems that show high sequence similarity to the HpyAV system, suggesting lateral transfer of a prototypic HpyAV-like R-M system among these microorganisms.

  10. Cofactor requirement of HpyAV restriction endonuclease.

    Science.gov (United States)

    Chan, Siu-Hong; Opitz, Lars; Higgins, Lauren; O'loane, Diana; Xu, Shuang-Yong

    2010-02-05

    Helicobacter pylori is the etiologic agent of common gastritis and a risk factor for gastric cancer. It is also one of the richest sources of Type II restriction-modification (R-M) systems in microorganisms. We have cloned, expressed and purified a new restriction endonuclease HpyAV from H. pylori strain 26695. We determined the HpyAV DNA recognition sequence and cleavage site as CCTTC 6/5. In addition, we found that HpyAV has a unique metal ion requirement: its cleavage activity is higher with transition metal ions than in Mg(++). The special metal ion requirement of HpyAV can be attributed to the presence of a HNH catalytic site similar to ColE9 nuclease instead of the canonical PD-X-D/EXK catalytic site found in many other REases. Site-directed mutagenesis was carried out to verify the catalytic residues of HpyAV. Mutation of the conserved metal-binding Asn311 and His320 to alanine eliminated cleavage activity. HpyAV variant H295A displayed approximately 1% of wt activity. Some HNH-type endonucleases have unique metal ion cofactor requirement for optimal activities. Homology modeling and site-directed mutagenesis confirmed that HpyAV is a member of the HNH nuclease family. The identification of catalytic residues in HpyAV paved the way for further engineering of the metal binding site. A survey of sequenced microbial genomes uncovered 10 putative R-M systems that show high sequence similarity to the HpyAV system, suggesting lateral transfer of a prototypic HpyAV-like R-M system among these microorganisms.

  11. En undersökning av Norwegians kriskommunikation under flygstrejken 2015. : En textanalys av Facebookinlägg och pressmeddelanden.

    OpenAIRE

    Emma, Mickelsson

    2016-01-01

    Numera lever vi i ett krissamhälle där vi nästan varje dag nås av budskap från olika typer av kriser. När en organisation drabbas av en kris är det viktigt att tänka på vilken kommunikation man använder för att nå ut med sitt budskap. Uppsatsens syfte var att undersöka hur en organisation använder sig av olika försvarsstrategier och retoriska appeller i sin kriskommunikation. Organisationen som valdes ut var flygbolaget Norwegian och deras hantering av den 11 dagar långa flygs...

  12. Kopiering av tradisjonskunst som læringsmetode

    Directory of Open Access Journals (Sweden)

    Mari Rorgemoen

    2011-07-01

    Full Text Available Artikkelen er skriven på bakgrunn av problematikk kring utvikling av ein forskingsbasert didaktikk for tekstilundervisninga på grunnstudiet ved Institutt for folkekultur, Høgskolen i Telemark. Delar av forskingsprosjektet tek difor utgangspunkt i eksisterande undervisnings­verksemd ved dette studiet. Spørsmåla som det er søkt å få svar på her, er: Kva dialog og læri­ng er framtredande ved kopiering av ein tradisjonell tekstilgjenstand? og: Korleis har denne arbeidsmåten ein plass i ein forskingsbasert didaktikk? Kopiprosessen skjedde i ein avgrensa oppgåveperiode, utført med to studentgrupper i 2008/2009. Intervju var valt som me­to­de saman med analyse av innhald i oppgåverapportar som var skrivne samtidig med kopiverksemda. I samband med utvikling av ein forskingsbasert didaktikk der kopiverksemd inngår, er drøftingane førte på grunnlag av sosiokulturell og sløydpedagogisk teori, saman med teori i møte med folkekunst. Kopiprosessen er relatert til ein verksemdsmodell for sløydfaget. Resultata er drøfta i høve til mål for oppgåva og gjeldande fagplan. Kopiering som læringsmetode har ein plass i ein forskingsbasert didaktikk når verksemda fører til erkjenning og integrert forståing, ikkje som rekonstruksjon av tradisjonar. Målet for ein forsk­ings­­basert didaktikk er horisontsamansmelting som følgje av hermeneutiske samtaler som gjeld samspel, spatialitet, spelereglar og spelerom i tradisjonen.

  13. Matglede hos barn : effekter av et læringsprogram

    OpenAIRE

    Myhrer, Kristine Svartebekk

    2013-01-01

    SAMMENDRAG Bakgrunnen for denne studien var Nasjonalt råd for ernærings nye kostholdsråd for den norske befolkningen. I rådene er det anbefalt å begrense inntaket av rødt kjøtt, bearbeidet kjøtt, salt, sukker og mettet fett for å forebygge kroniske kostrelaterte sykdommer i befolkningen, slik som diabetes og overvekt. For å påvirke barns valg av mat mot et sunnere kosthold er det behov for å forstå faktorer som kan påvirke barnas valg og aksept av matvarer Formålet med masteroppgaven e...

  14. Phase 4 paroxysmal AV block in a patient with scleroderma.

    Science.gov (United States)

    Butschek, Ross; Powell, Brian D; Littmann, Laszlo

    2013-01-01

    A 72-year-old man with limited cutaneous systemic scleroderma was hospitalized for two episodes of witnessed syncope. The baseline 12-lead electrocardiogram was normal but on telemetry there were numerous episodes of paroxysmal AV block with asystolic periods of up to 7.5 s duration. Analysis of the rhythm strips revealed phase 4 intra-His bundle block characterized by critical P-P intervals that triggered the AV block, and a narrow range of junctional escape to subsequent P wave intervals that were required to release the AV block. A dual chamber pacemaker was implanted. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. A case of pancreatic AV malformation in an elderly man.

    Science.gov (United States)

    Gupta, Vipin; Kedia, Saurabh; Sonika, Ujjwal; Madhusudhan, Kumble Seetharama; Pal, Sujoy; Garg, Pramod

    2018-02-05

    A 60-year-old man presented with recurrent abdominal pain and weight loss for 6 months. Abdominal imaging showed a large vascular lesion in the head and neck of pancreas suggestive of arteriovenous malformation (AV malformation). Endoscopic ultrasound was done which showed features of AV malformation with no evidence of pancreatic malignancy. Surgery was planned for definitive treatment of malformation. Digital subtraction angiography with angioembolization was done prior to surgery to reduce vascularity of the lesion. He recovered after a pylorus preserving pancreaticoduodenectomy. Histopathology of the resected specimen confirmed the pancreatic AV malformation. There has been no recurrence at 2 years of follow-up.

  16. Grekisk mytologi i The Lightning Thief av Rick Riordan

    OpenAIRE

    Liu, Olivia

    2017-01-01

    Syftet med denna undersökning är att genom en komparativ studie med utgångspunkt i teorier om dialogicitet, hyptertextualitet och transformation, analysera förekomsten av grekisk mytologi i The Lightning Thief (2005) – vilken påverkan dessa har och hur de tar sig uttryck i Riordans roman. De grekiska myterna i The Lightning Thief har jämförts med de som beskrivs i Grekisk Mytologi (1977) av Giovanni Caselli och Michael Gibson, En introduktion till grekisk mytologi (1989) av David Bellingham, ...

  17. Turbulens? - Norske nettavisers omtale av Norwegian 2013. [En kvantitativ innholdsanalyse av VG, DB, Aftenposten, NRK og DNs dekning av Norwegians Dreamliner-kjøp

    OpenAIRE

    Knudsen, Anders

    2015-01-01

    Analysen tar for seg omtale av flyselskapet Norwegian i de fem norske nettavisene VG.no, DB.no, Aftenposten.no, NRK.no og DN.no. Prosjektet fokuserer på artiklenes vinkling og hvordan selskapet omtales i forbindelse med Dreamliner-skandalen, med utgangspunkt i dagsordenfunksjonen og teorien om framing. For å belyse dette har jeg tatt utgangspunkt i følgende problemstilling: Hvordan vinklet og fokuserte norske nettaviser i 2013 på Norwegians kjøp og innføring av nye Dre...

  18. Navy AV-8B Crash Survivable Flight Incident Recorder (CSFIR)

    National Research Council Canada - National Science Library

    1998-01-01

    ...) met at the Naval Air Weapons Development Center, Building P302, China Lake, CA for a Program Review I Technical Interchange Meeting in support of the AV-8B Crash Survivable Flight Incident Recorder System (CSFIR...

  19. Open Source AV solution supporting In Situ Simulation

    DEFF Research Database (Denmark)

    Krogh, Kristian; Pociunas, Gintas; Dahl, Mads Ronald

    the software to meet our expectations for a portable AV system for VAD. The system would make use of “off the shelf” hardware components which are widely available and easily replaced or expanded. The developed AV software and coding is contracted to be available as Copyleft Open Source to ensure low cost...... a stable AV software that has be developed and implemented for an in situ simulation initiative. This version (1.3) is the first on released as Open Source (Copyleft) software (see QR tag). We have found that it is possible to deliver multi-camera video assisted debriefing in a mobile, in situ simulation...... environment using an AV system constructed from “off the shelf” components and Open Source software....

  20. Knihovna Sociologického ústavu AV ČR

    Czech Academy of Sciences Publication Activity Database

    Hesová, Nela

    2017-01-01

    Roč. 7, č. 3 (2017) E-ISSN 1805-2800 Institutional support: RVO:68378025 Keywords : library Subject RIV: AF - Documentation, Librarianship, Information Studies https://www.lib.cas.cz/casopis-informace/knihovna-sociologickeho-ustavu-av-cr/

  1. EST Table: AV404029 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404029 pg--0356 11/12/09 n.h 10/09/28 99 %/103 aa ref|YP_003044625.1| hypothetica...n ECD_01416 [Escherichia coli BL21(DE3)] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV404029 pg-- ...

  2. EST Table: AV404052 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404052 pg--0383 10/09/28 90 %/146 aa ref|YP_002386254.1| Major tail protein V [Es...cherichia coli IAI1] emb|CAQ97657.1| Major tail protein V [Escherichia coli IAI1] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV404143 pg-- ...

  3. EST Table: AV403989 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403989 pg--0306 10/09/28 100 %/137 aa ref|NP_037751.1| Q protein [Enterobacteria ...phage HK97] gb|AAF31144.1| Q protein [Enterobacteria phage HK97] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV404408 pg-- ...

  4. EST Table: AV399390 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV399390 NV120162 11/12/09 n.h 10/09/28 100 %/181 aa ref|YP_002884244.1| Ac13-like ...yhedrovirus] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV399390 NV12 ...

  5. The role of AV and VV optimization for CRT

    Directory of Open Access Journals (Sweden)

    William W. Brabham, M.D.

    2013-06-01

    Full Text Available Cardiac resynchronization therapy is an effective therapy for patients with left ventricular systolic dysfunction and a ventricular conduction delay; however, approximately 30% of patients do not experience significant clinical improvement with this treatment. Modern devices allow individualized programming of the AV delay and VV offset, which offer the possibility of improving clinical response rates with optimized programming. AV and VV delay optimization techniques have included echocardiography, device-based algorithms, and several other novel noninvasive techniques. While an acute improvement in hemodynamic function has been clearly demonstrated with optimized device settings, long-term clinical benefit is limited. In the majority of cases, an empiric AV delay with simultaneous biventricular or left ventricular pacing is adequate. The value of optimization of these intervals in “non-responders” still requires further investigation.

  6. Brachial artery aneurysms following brachio-cephalic AV fistula ligation.

    Science.gov (United States)

    Khalid, Usman; Parkinson, Frances; Mohiuddin, Kamran; Davies, Paula; Woolgar, Justin

    2014-01-01

    Peripheral artery aneurysms proximal to a long-standing arteriovenous (AV) fistula can be a serious complication. It is important to be aware of this and manage it appropriately. Vascular access nurses input all data regarding patients undergoing dialysis access procedures into a securely held database prospectively. This was retrospectively reviewed to identify cases of brachial artery aneurysms over the last 3 years. In Morriston Hospital, around 200 forearm and arm AV fistulas are performed annually for vascular access in renal dialysis patients. Of these, approximately 15 (7.5%) are ligated. Three patients who had developed brachial artery aneurysms following AV fistula ligation were identified. All 3 patients had developed brachial artery aneurysms following ligation of a long-standing brachio-cephalic AV fistula. Two patients presented with pain and a pulsatile mass in the arm, and one presented with pins and needles and discoloration of fingertips. Two were managed with resection of the aneurysm and reconstruction with a reversed long saphenous vein interposition graft, the third simply required ligation of a feeding arterial branch. True aneurysm formation proximal to an AV fistula that has been ligated is a rare complication. There are several reasons for why these aneurysms develop in such patients, the most plausible one being the increase in blood flow and resistance following ligation of the AV fistula. Of note, all the patients in this study were on immunosuppressive therapy following successful renal transplantation. Vigilance by the vascular access team and nephrologists is paramount to identify those patients who may warrant further evaluation and investigation by the vascular surgeon.

  7. Lesing av delvis motstridende tekster i syvende klasse

    Directory of Open Access Journals (Sweden)

    Wenke Mork Rogne

    2013-06-01

    Full Text Available I denne artikkelen ser vi på hvilken type informasjon elever i 7. klasse vektlegger for å konstruere en sammenhengende oppsummering av fire til dels motstridende tekster. Elever møter ofte flere tekster om samme tema – multiple tekster – og vi trenger økt kunnskap om hvordan de leser slike tekster. Elevene leste fire ulike tekster om en sykkelulykke. Tekstene presenterte informasjon som var delvis sammenfallende på tvers av alle tekstene, og delvis motstridende informasjon som innebar at enkelte tekster ga ulike beskrivelser av hendelsesforløpet. Vi testet elevenes ordavkodingsferdigheter, fikk dem til å fylle ut et spørreskjema om lesevaner og vi innhentet elevenes resultater på Nasjonal leseprøve. Etter lesing ba vi elevene gi en oppsummering av sykkelulykken. Elevene gjenga relativt mer sammenfallende informasjon enn motstridende informasjon. Gode resultater på Nasjonal leseprøve ser ut til å ha en sammenheng med elevenes ferdigheter i å konstruere en sammenhengende forståelse av de fire tekstene. Elever som oppga å lese mye på Internett hadde imidlertid fått med mindre av informasjonen som var felles for de fire tekstene i sine oppsummeringer. Vi fant også en negativ sammenheng mellom fritidslesing på Internett og resultatene fra Nasjonal leseprøve. Samlet sett indikerer resultatene at når elevene skal skape sammenheng mellom flere delvis motstridende tekster, så blir sammenfallende informasjon vektlagt mer enn motstridende informasjon. Dessuten ser det ut til at de elevene som bruker mest fritid til å lese på Internett, sliter mer med å sammenfatte innholdet i de fire tekstene enn de andre elevene.

  8. Högstadieelevers upplevelse av sex- och samlevnadsundervisning : en intervjustudie

    OpenAIRE

    Ejder, Alina; Karlsson, Sanna

    2016-01-01

    En god sex- och samlevnadsundervisning i skolan är central för att ha möjlighet att utveckla en god hälsa, vilken dock enligt tidigare forskning har visats vara av bristande kvalitet. Syftet med studien är att undersöka högstadieelevers upplevelse av sex- och samlevnadsundervisningen på deras skola, med fokus på pedagog ledda lektioner. Studiens metod var en kvalitativ intervjustudie, där sex högstadieelever intervjuades individuellt. Resultatet visade att eleverna upplevde att undervisningen...

  9. EST Table: AV404040 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404040 pg--0370 11/12/09 GO hit GO:0006810(transport)|GO:0006865(amino acid trans...e transport) 10/09/28 83 %/164 aa pdb|3L1L|A Chain A, Structure Of Arg-Bound Escherichia Coli Adic 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV404040 pg-- ...

  10. Revisjon av anleggskontrakter i henhold til god revisjonsskikk

    OpenAIRE

    Woxen, Hans Jacob; Feng, Yennie Jie Zhen

    2014-01-01

    Prosjektregnskap må føres når anleggskontrakter foreligger. I de tilfelle disse inneholder vesentlig feilinformasjon, påvirker dette årsregnskapet i tilsvarende grad. Hvordan revisor må revidere for å ivareta kravet til god revisjonsskikk, utgjør problemstillingen som ligger til grunn for denne masteroppgaven. Anleggskontrakter er ifølge IAS 11 kontrakter som er særlig fremforhandlet for tilvirkning av en eiendel eller en kombinasjon av eiendeler. Denne definisjonen utdypes ...

  11. EST Table: AV403981 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available terminase large subunit (DNA packaging protein A) from bacteriophage origin [Escherichia coli UMN026] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h AV403981 pg-- ... ...AV403981 pg--0297 11/12/09 n.h 10/09/28 100 %/265 aa ref|YP_002411376.1| terminase large subunit (DNA packag...ing protein A) from bacteriophage origin [Escherichia coli UMN026] emb|CAR11828.1|

  12. EST Table: AV398396 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV398396 NV021762 11/12/09 GO hit GO:0005622(intracellular)|GO:0008270(zinc ion bin...ding) 10/09/28 n.h 10/08/28 n.h 10/08/27 n.h 10/09/10 30 %/120 aa AGAP003111-PA Protein|2R:32505726:32508690:1|gene:AGAP003111 10/09/10 n.h 10/09/10 n.h AV398396 NV02 ...

  13. Etableringen av Tesla Motors på det norske bilmarkedet : en empirisk studie av salgsdrivere og konkurranseeffekter

    OpenAIRE

    Asperheim, Hanne Henjum; Vedum, Anders

    2015-01-01

    Denne masterutredningen er en empirisk studie av Tesla Motors’ etablering på det norske bilmarkedet. Vi gjennomfører to separate analyser: Først fokuseres det på geografiske salgsforskjeller, deretter på effekten Tesla Motors har hatt på det norske nybilmarkedet. I vår første analyse utvikler vi en modell for å identifisere Teslas salgsdrivere, i form av geografiske og sosioøkonomiske variabler. Resultatene viser at et fylkes inntektsnivå, utdanningsnivå og miljøbevissthet har en positiv s...

  14. EST Table: AV404642 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404642 prgv0279 10/09/28 81 %/116 aa ref|NP_001091796.1| programmed cell death pr...otein 5-like protein [Bombyx mori] gb|ABJ97180.1| programmed cell death protein 5-like protein [Bombyx mori

  15. The apolipoprotein AV gene and diurnal triglyceridaemia in normolipidaemic subjects

    NARCIS (Netherlands)

    Masana, L; Ribalta, J; Salazar, J; Fernandez-Ballart, J; Joven, J; Cabezas, MC

    2003-01-01

    The newly recognised apolipoprotein (apo) AV gene (APOAV) has been linked to fasting plasma triglyceride (TG) concentrations with some polymorphisms associated with elevated fasting TGs. Since fasting plasma TGs are mainly determined by the hepatic production of TGrich particles (very low density

  16. User guide of AVS/ITBL for numerical environmental system

    International Nuclear Information System (INIS)

    Suzuki, Yoshio; Matsumoto, Nobuko; Yamagishi, Nobuhiro; Arakawa, Takuya; Kuraishi, Hideaki

    2005-02-01

    The Center for Promotion of Computational Science and Engineering of the Japan Atomic Energy Research Institute has carried out the ITBL (Information-Technology Based Laboratory) project which is one of e-Japan priority policy programs. The goal of the ITBL project is to create the vertical research environment in which intellectual resources such as remote computers, programs and data can be shared in Japanese research institutions and cooperative studies among researchers can be supported. AVS/ITBL is the visualization tool which has been developed aiming at realizing the efficient visualization in the ITBL environment. This visualization tool is one of the tools of ITBL infrastructure software and operates in cooperation with AVS/Express. Main functions of AVS/ITBL are as follows: it can directly read data files located on remote computers, it can display and control an image on the web browser, it can collaboratively display an image among remote researchers, and it can perform visualization process as a batch. In this paper, utilization of AVS/ITBL to the numerical environmental system, which is one of the applications in ITBL project, is presented. And the outline of the operation in this utilization is indicated. (author)

  17. Rektorers forståelse av mobbing i skolen

    DEFF Research Database (Denmark)

    Hansen, Helle Rabøl

    2008-01-01

    PÅ opfordring fra redaktionen gives en kommentar med dansk vinkel til den norske artikel 'Rektorers forståelse av mobbning i skolen'.Den omtalte artikel er at betragte som første trin i indførelse af en nordisk mobbeforståelse med undgangspunkt i Dan Olweus begrebsafgrænsning.Der savnes også en i...

  18. Mutagenesis in ORF AV2 affects viral replication in Mungbean ...

    Indian Academy of Sciences (India)

    Mungbean yellow mosaic India virus (MYMIV) is a whitefly-transmitted begomovirus with a bipartite genome. .... 1996) and in Indian cassava mosaic virus (Rothenstein et al. 2007). The ability of AV2 of another bipartite begomovirus, East African cassava mosaic Cameroon virus ...... (New York: WH Freeman and Company).

  19. EST Table: AV403752 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403752 pg--0009 10/09/28 100 %/257 aa ref|YP_002411376.1| terminase large subunit (DNA packaging... protein A) from bacteriophage origin [Escherichia coli UMN026] emb|CAR11828.1| terminase large subunit (DNA packaging

  20. EST Table: AV403922 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403922 pg--0214 10/09/28 91 %/142 aa ref|ZP_06118881.2| DNA packaging protein FI ...[Clostridium hathewayi DSM 13479] gb|EFC94454.1| DNA packaging protein FI [Clostridium hathewayi DSM 13479

  1. EST Table: AV404246 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404246 pg--0747 10/09/28 91 %/130 aa ref|ZP_06118881.2| DNA packaging protein FI ...[Clostridium hathewayi DSM 13479] gb|EFC94454.1| DNA packaging protein FI [Clostridium hathewayi DSM 13479

  2. EST Table: AV399507 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV399507 NV120319 10/09/28 70 %/144 aa ref|YP_803401.1| baculovirus repeated ORF-b [Anticars...ia gemmatalis nucleopolyhedrovirus] gb|ABI13791.1| baculovirus repeated ORF-b [Anticarsia gemmatali

  3. Påliteligheten av selvrapportert alkoholkonsum. Svalbardstudien 1988-89

    Directory of Open Access Journals (Sweden)

    Georg Høyer m. fl

    2009-10-01

    Full Text Available  SAMMENDRAGSvalbard er spesielt godt egnet til å vurdere påliteligheten av selvrapportert alkoholkonsum. På grunn av detlave prisnivået for alkohol er ulovlig import eller hjemmeproduksjon av alkohol ukjent på Svalbard. Dessutener samfunnet lite og oversiktlig, slik at det er praktisk mulig å undersøke hele befolkningen. I den aktuellestudien registrerte vi alt salg av alkohol til fastboende nordmenn på Svalbard i oktober og november 1988. Isamme tidsperiode ble alle nordmenn 18 år eller eldre invitert til å ta del i en helseundersøkelse der det inngikkspørsmål om alkoholbruk. Vi fant at selvrapportert alkoholkonsum utgjorde rundt 40% av salgsvolumet.På grunn av de spesielle forhold når det gjelder alkoholomsetning på Svalbard er det grunn til å anta atestimatet i denne studien er mer pålitelig sammenlignet med tilsvarende studier fra andre områder.Høyer G, Nilssen O, Brenn T, Schirmer H. The reliability of self-reported alcohol consumption.The Svalbard study 1988-89. Nor J Epidemiol 1996; 6 (1: 109-113.ENGLISH SUMMARYThe Norwegian island of Spitzbergen, Svalbard offers a unique setting for validation studies on self-reportedalcohol consumption. No counterfeit production or illegal import exists, thus making a complete registrationof all sources of alcohol possible. In this study we recorded sales from all agencies selling alcohol onSvalbard over a two month period in 1988. During the same period all adults living permanently on Svalbardwere invited to take part in a health screening. As part of the screening a self-administered questionnaire onalcohol consumption was introduced to the participants. We found that the self-reported volume accounted forapproximately 40 percent of the sales volume. Because of the unique situation applying to Svalbard, theestimate made in this study is believed to be more reliable compared to other studies using sales volume tovalidate self-reports.

  4. Validation of a Real-time AVS Encoder on FPGA

    Directory of Open Access Journals (Sweden)

    Qun Fang Yuan

    2014-01-01

    Full Text Available A whole I frame AVS real-time video encoder is designed and implemented on FPGA platform in this paper. The system uses the structure of the flow calculation, coupled with a dual-port RAM memory between/among the various functional modules. Reusable design and pipeline design are used to optimize various encoding module and to ensure the efficient operation of the pipeline. Through the simulation of ISE software and the verification of Xilinx Vritex-4 pro platform, it can be seen that the highest working frequency can be up to 110 MHz, meeting the requirements of the whole I frame real- time encoding of AVS in CIF resolution.

  5. Wirevagn : Utvecklingen av en utrullare för hisslinor

    OpenAIRE

    Rehnsfeldt, Patrik

    2014-01-01

    Kandidatexamensarbetet som utgick från en förfrågan från företaget Irongrip AB hade som mål att utveckla ett produktförslag på en utlindare av stålvajer för hissmontörer. Irongrip AB som tillverkar och säljer verktyg för hantering av stålvajer hade uppmärksammat att en efterfrågan på en sådan produkt fanns på marknaden då befintliga lösningar var bristfälliga och inte hade alla de funktioner som är önskvärda hos en sådan produkt.Arbetet inleddes med en förstudie där studiebesök vid lindragnin...

  6. EST Table: AV402406 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV402406 heS00974 10/09/28 59 %/223 aa ref|XP_001656104.1| dipeptidyl peptidase iii...174102|DmojGI24885-PA 10/08/27 40 %/219 aa F02E9.9b#CE41217#WBGene00008532#status...ref|XP_972969.2| PREDICTED: similar to dipeptidyl peptidase iii [Tribolium castaneum] FS761400 heS0 ...

  7. Beregning av lokk, håndberegningsmetoder versus FEM

    OpenAIRE

    Bruder, Ørjan Myklestad

    2014-01-01

    Ved dimensjonering av lokk benyttes vanligvis elementmetoden (FEM) til å fastlegge spenning og deformasjon i konstruksjonen. Det finnes flere håndberegningsmetoder for å verifisere FEM-resultatene, men det er lite tilgjengelig litteratur om temaet, og lite er gjort for å sammenligne metodene. IMT ved NMBU ønsker å styrke fagkunnskapen innenfor dette temaet og har derfor initiert denne mastergradsoppgaven. Målsettingen med denne oppgaven har vært å sammenligne ulike håndberegningsformler for ...

  8. EST Table: AV403457 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403457 msgV0503 10/09/28 90 %/177 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  9. EST Table: AV403247 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403247 msgV0234 10/09/28 91 %/189 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  10. EST Table: AV403467 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403467 msgV0519 10/09/28 85 %/159 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  11. EST Table: AV403356 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403356 msgV0366 10/09/28 66 %/121 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB985569 msgV ...

  12. EST Table: AV403304 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403304 msgV0310 10/09/28 85 %/165 aa ref|NP_001166287.1| sericin 2 isoform 1 prec...ursor [Bombyx mori] gb|ADA84147.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  13. EST Table: AV403504 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403504 msgV0623 10/09/28 98 %/114 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  14. EST Table: AV403487 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403487 msgV0602 10/09/28 95 %/130 aa ref|NP_001166287.1| sericin 2 isoform 1 prec...ursor [Bombyx mori] gb|ADA84147.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  15. EST Table: AV403164 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403164 msgV0119 10/09/28 84 %/120 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  16. EST Table: AV403698 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403698 msgV0982 10/09/28 85 %/164 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  17. EST Table: AV403268 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403268 msgV0258 10/09/28 62 %/158 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  18. EST Table: AV403374 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403374 msgV0392 10/09/28 86 %/135 aa ref|NP_001166287.1| sericin 2 isoform 1 prec...ursor [Bombyx mori] gb|ADA84147.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  19. EST Table: AV403444 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403444 msgV0485 10/09/28 80 %/156 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  20. EST Table: AV403508 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403508 msgV0629 10/09/28 79 %/122 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h NM_001172817 msgV ...

  1. EST Table: AV403123 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403123 msgV0067 10/09/28 65 %/125 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB985569 msgV ...

  2. EST Table: AV403443 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403443 msgV0483 10/09/28 62 %/162 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB985569 msgV ...

  3. EST Table: AV403596 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403596 msgV0735 10/09/28 60 %/200 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB985569 msgV ...

  4. EST Table: AV403709 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV403709 msgV0994 10/09/28 61 %/173 aa ref|NP_001166288.1| sericin 2 isoform 2 prec...ursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 n.h 10/08/27 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h BB985569 msgV ...

  5. Bruk av studenter som medforskere- et pilotprosjekt i barnevernsfeltet

    Directory of Open Access Journals (Sweden)

    Kjersti Ørvig

    2014-02-01

    Full Text Available Denne artikkelen retter fokus mot studenters læring i praksis. Gjennom beskrivelsen av et pilotprosjekt i barnevernet, ønsker vi å synliggjøre hvordan bruken av studenter som medforskere kan bidra til økt kunnskapsutbytte samt en større forståelse av samspillet mellom teori og praksis. Samtidig har feltet sosialt arbeid behov for en modernisering. Denne artikkelen søker å vise at bruk av studenter som medforskere kan bidra til den nevnte modernisering. To spørsmål reises i artikkelen: Hvordan håndterer lærere og studenter utfordringer i forskningsprosessen i prosjekter hvor studenter deltar som medforskere? På hvilken måte kan praksisnær forskning bidra til å kaste lys over studentens læring? Abstract Students as research assistants – a pilot project in child welfare services.This article concerns students’ learning outcomes. Through a description of a pilot project in child welfare services, the aim is to demonstrate how the use of students as research assistants can contribute to increased knowledge outcomes and provide a better understanding of the interaction between theory and practice. At the same time, the field of social work needs a modernization. The article argues that the use of students as research assistants can contribute to the aforementioned modernization. Two issues are raised in the article: How to deal with teachers’ and students’ challenges in the research process in projects where students participate as research assistants? In what way can survivor research shed light on students’ learning outcomes?

  6. Inkludering av ungdom med minoritetsbakgrunn i NIF-organisert idrett

    Directory of Open Access Journals (Sweden)

    Mari Kristin Sisjord

    2014-10-01

    Full Text Available Norges Idrettsforbund og Olympiske og Paralympiske Komité (NIF har en uttalt målsetting om en åpen og inkluderende idrett. Hvordan kommer dette til uttrykk i den praktiske virksomheten? Denne artikkelen, som bygger på data fra en undersøkelse om likestilling og mangfold i den organiserte idretten (NIF, retter søkelyset mot arbeid med inklusjon av ungdom med minoritetsbakgrunn på ulike organisasjonsnivå i NIF: særforbund, idrettskretser og idrettslag. Datamaterialet er kvalitative intervju med representanter fra ulike organisasjonsnivå. Resultatene viser at NIFs overordnede politikk i varierende grad nedfelles i særforbundenes virksomhet, i idrettskretsene og i idrettslagene. Av særforbundene skiller Fotballforbundet og Klatreforbundet seg ut som aktive pådrivere i arbeidet med inkludering. Mange idrettslag oppfattet slike spørsmål som lite aktuelle i sitt rekrutteringsområde. Representanter for lag som hadde erfaring med inkludering og rekruttering av minoritetsungdom, tilkjennega varierte erfaringer og synspunkter.

  7. Torsional changes in surgery for A-V phenomena.

    Science.gov (United States)

    Sharma, P; Halder, M; Prakash, P

    1997-03-01

    The role of torsion in the aetiopathogenesis of A-V phenomena has not been sufficiently emphasized. The success of vertical displacement of horizontal recti in correction of A or V has not been attributed to torsional changes. To evaluate this aspect, 21 cases of A or V phenomena were subjected to monocular recession-resection procedure with vertical shifting. Preoperative and postoperative torsional changes were evaluated on synoptophore (subjective torsion), and confirmed by fundus photography (objective torsion). Intorsion with A phenomenon was seen preoperatively in 5 of 8 cases which increased after surgery and was seen postoperatively in the other 3 cases also. Extorsion was observed in 5 of 13 cases pre operatively in 'V' phenomenon, but the changes in extorsion after surgery were less dramatic than those in intorsion. The oblique overactions were reduced in cases where they were present. Correction of A-V phenomena by torsion induced by vertical shifting of horizontal recti muscles is proposed, highlighting the role of torsion in A-V phenomena.

  8. Torsional changes in surgery for A-V phenomena

    Directory of Open Access Journals (Sweden)

    Sharma Pradeep

    1997-01-01

    Full Text Available The role of torsion in the aetiopathogenesis of A-V phenomena has not been sufficiently emphasized. The success of vertical displacement of horizontal recti in correction of A or V has not been attributed to torsional changes. To evaluate this aspect, 21 cases of A or V phenomena were subjected to monocular recession-resection procedure with vertical shifting. Preoperative and postoperative torsional changes were evaluated on synoptophore (subjective torsion, and confirmed by fundus photography (objective torsion. Intorsion with A phenomenon was seen preoperatively in 5 of 8 cases which increased after surgery and was seen postoperatively in the other 3 cases also. Extorsion was observed in 5 of 13 cases pre operatively in ′V′ phenomenon, but the changes in extorsion after surgery were less dramatic than those in intorsion. The oblique overactions were reduced in cases where they were present. Correction of A-V phenomena by torsion induced by vertical shifting of horizontal recti muscles is proposed, highlighting the role of torsion in A-V phenomena.

  9. Har forhold under svangerskapet betydning for utviklingen av otitis media?

    Directory of Open Access Journals (Sweden)

    Kari J. Kværner

    2009-10-01

    Full Text Available  SAMMENDRAGMed utgangspunkt i data fra et populasjonsbasert utvalg av 7 992 norske tvillinger ble sammenhengenmellom gjentatte ørebetennelser og forhold under svangerskapet studert. Som parametre på intrauterinevekstforhold ble informasjon om fødselsvekt og gestasjonsalder fra Medisinsk Fødselsregister benyttet.Informasjon om rapporterte øreinfeksjoner ble basert på spørreskjemaer som ble besvart av tvillingene ialderen 18–25 år. Først studerte vi individuelle effekter av fødselsvekt og gestasjonsalder på forekomsten avotitis media (OM. Rapportert fødselsvekt hos individer med OM var signifikant lavere enn hos kontrollene,med en gjennomsnittsforskjell på 86 gram. Hos de som rapporterte OM var gjennomsnittlig gestasjonsalder3 dager kortere enn i kontrollmaterialet. Deretter beregnet vi effekten av fødselsvekt ved bruk av co-twinkontroll metoden. Blant monozygote (MZ tvillingpar gjenspeiler fødselsvektforskjeller innenfor tvillingparetintra-uterine miljøforskjeller. Blant dizygote (DZ par kan vektforskjellen være både genetiske ogmiljøbetinget. Ved sammenligning av fødselsvektforskjeller innenfor tvillingparene er tvillingen som ikkehar gjentatte øreinfeksjoner en matchet kontroll blant OM diskordante par. Resultatene antyder at lavfødselsvekt er en risikofaktor for otitis media. Gjennomsnittlig vektforskjell blant par diskordante for OMvar 48 gram, og den av tvillingen som ikke rapporterte OM hadde signifikant høyere fødselsvekt.Kværner KJ, Tambs K, Harris J, Magnus P. Do pregnancy-related factors influence the development ofotitis media? Nor J Epidemiol 1997; 7 (1: 55-58.  ENGLISH SUMMARYThe association between intrauterine growth, as measured by weight and gestational age, and the occurrenceof recurrent ear infections was studied using data from a population based sample of 7992 Norwegian twins.Perinatal measures were collected from the Medical Birth Registry, and reports of recurrent ear infectionswere based on

  10. Tristrams saga ok Isöndar og Tristan und Isold - En lesning av to versjoner av Tristan-legenden

    OpenAIRE

    Jensen, Kristian Arnstein

    2015-01-01

    Abstrakt (norsk) / Abstract (Norwegian) Oppgaven omhandler den norrøne og middelaldertyske versjonen av legenden om Tristan og Isolde. Kjærlighetsmotivet sammenliknes og fortellingen sammenliknes med et eventyr. Vladimir Propps og A. J. Greimas teorier om litteraturteori i forhold til fortellingen taes i bruk. Abstract (engelsk) / Abstract (English) The assignment is about the old norse and medieval german version of the legend of Tristan and Isolde. The love motive is compa...

  11. Å LESE MEDIETEKSTER PÅ IPADEN. Observasjoner av en medievant fireårings bruk av iPad i hjemmet

    Directory of Open Access Journals (Sweden)

    Henriette Jæger

    2016-06-01

    Full Text Available Artikkelen tar utgangspunkt i tre observasjoner av en gutt på fire år som bruker iPad på fritiden. Den søker å synliggjøre de strategiene dette barnet velger for å skaffe seg tilgang til ulike medietekster, hvordan han leser og tolker dem, og den undersøker eventuelle spor av kritisk refleksjon hos barnet over disse tekstene. Teoretisk sett hviler den på en forståelse av mediekompetanse som en parallell prosess til utvikling av lese- og skrivekyndighet (literacy, og medieopplevelsene omtales som viktige møter med tekst. Artikkelen undersøker hvordan å lese medietekster kan legge et grunnlag for å utvikle en utvidet tekstkompetanse eller mediekompetanse. Konklusjonen legger vekt på motivasjon og lekenhet som barns primære inngang til medietekstene og som et grunnlag for å utvikle mediekompetanse (media literacy. The article is based on three observations of a four-year-old boy who uses the iPad in his spare time. It demonstrates the strategies that this boy applies to gain access to various media texts, and how he reads and interprets them. It also seeks to examine traces of critical reflection that he may demonstrate in relation to these texts. Theoretically, it rests on an understanding of media literacy as a parallel process to the development of literacy, and it seeks to demonstrate how reading media texts can create an important starting point for the development of media literacy. The Kindergarten practitioner’s role and opportunities to develop children's media literacy within a kindergarten context is a focus towards the end of the article. In conclusion, I argue that motivation and playfulness are important approaches to media texts and create an important foundation for the development of media literacy

  12. Hvilken rolle spiller hybrid shopping i kundereisen ved kjøp av kosmetikk?

    OpenAIRE

    Varem, Andrea; Nervik, Lene

    2017-01-01

    Temaet for denne bacheloroppgaven er hybrid shopping i kundereisen ved kjøp av kosmetikk. Etter en omfattende gjennomgang av eksisterende teori rundt kundereisen fikk vi et inntrykk av at det er et gap i forskningen knyttet til kundereisen ved kjøp av kosmetikk, på tross av størrelsen på dette markedet. Det vi fant av teori på feltet var i stor grad basert på kvantitative undersøkelser, og vi ønsker derfor å belyse kundereisen i denne konteksten gjennom et kvalitativt forskningsdesign. Med ut...

  13. Rettferdige minutter: Fordeling av spilletid i fotballkamper for aldersbestemte klasser

    Directory of Open Access Journals (Sweden)

    Trine Anker

    2010-01-01

    Full Text Available På et fotballag i overgangen mellom barne- og ungdomsfotballen er spilletid på fotballbanen under kamp både en knapp ressurs og en kilde til diskusjoner om fordeling. Spørsmålet som er utgangspunkt for denne artikkelen, er hvilke hensyn som bør tas når trener og lagleder skal fordele samlet spilletid på enkeltspillere. Er det viktigst å vinne fotballkampen, eller har det størst betydning å fordele spilletiden mest mulig likt mellom spillerne? Skal det tas hensyn til guttenes evner, motivasjon og preferanser? Er deres familiebakgrunn og personlighet av betydning? Diskusjonen baserer seg på en gjennomgang av ulike politiske rettferdighetsteorier for fordeling av knappe goder.Nøkkelord: rettferdighet, practice, fordelingsrettferdighet, diskursetikk, idrettsetikkEnglish summary: Minutes of justice: Distribution of time during football matches in a boys' teamDuring a football match, time for playing can be considered as a limited good. In this article the point of departure is the redistribution of time in a boys' football team in the transition phase between children and youth football. The questions are how and under which conditions time for playing should be distributed among the players. Is winning the game more important than trying to let every player play for an equal amount of time? Should the boys' talents, motivation, and preferences be considered while distributing time, or are family background and personality of importance? Different theories of political justice for the distribution of limited goods underpin the discussion of how to distribute the minutes of playing time during a football match.http://dx.doi.org/10.5324/eip.v4i1.1737

  14. Artificial vision support system (AVS(2)) for improved prosthetic vision.

    Science.gov (United States)

    Fink, Wolfgang; Tarbell, Mark A

    2014-11-01

    State-of-the-art and upcoming camera-driven, implanted artificial vision systems provide only tens to hundreds of electrodes, affording only limited visual perception for blind subjects. Therefore, real time image processing is crucial to enhance and optimize this limited perception. Since tens or hundreds of pixels/electrodes allow only for a very crude approximation of the typically megapixel optical resolution of the external camera image feed, the preservation and enhancement of contrast differences and transitions, such as edges, are especially important compared to picture details such as object texture. An Artificial Vision Support System (AVS(2)) is devised that displays the captured video stream in a pixelation conforming to the dimension of the epi-retinal implant electrode array. AVS(2), using efficient image processing modules, modifies the captured video stream in real time, enhancing 'present but hidden' objects to overcome inadequacies or extremes in the camera imagery. As a result, visual prosthesis carriers may now be able to discern such objects in their 'field-of-view', thus enabling mobility in environments that would otherwise be too hazardous to navigate. The image processing modules can be engaged repeatedly in a user-defined order, which is a unique capability. AVS(2) is directly applicable to any artificial vision system that is based on an imaging modality (video, infrared, sound, ultrasound, microwave, radar, etc.) as the first step in the stimulation/processing cascade, such as: retinal implants (i.e. epi-retinal, sub-retinal, suprachoroidal), optic nerve implants, cortical implants, electric tongue stimulators, or tactile stimulators.

  15. Implementering av HMS-system ved Frank Mohn Fusa AS

    OpenAIRE

    Jørgensen, Hilde

    2008-01-01

    Det stilles stadig strengere HMS- og kvalitetskrav til virksomheter. Frank Mohn Fusa AS må overholde krav fra myndigheter, interne krav, kundekrav og krav i henhold til bedriftens ISO 9001:2000 sertifisering. Bedriften hadde et HMS- og kvalitetssystem, som ved hjelp av en operasjonsmanual og en kvalitetshåndbok dokumenterte de fleste krav, men bedriften behøvde et mer effektivt, kostnadsbesparende og moderne system! Det ble utført Compliance-målinger opp mot ISO 9001:2000 og In...

  16. Posthumanisme /nymaterialisme og nomadisme - affektive brytninger av barnehagens observasjonspraksiser

    Directory of Open Access Journals (Sweden)

    Ann Merete Otterstad

    2015-09-01

    Full Text Available This article challenges observation as a method in early childhood, justified as a mapping tool for creating knowledge about children. Observation as data material is about writing down already known categorisation about children and their development. Categories and categorisation make a foundation for correspondence and coherence   - connections that might create generalising knowledge about children in early years. The article is about a research project conducted in a child-centre over a two-year period. We had an on-going conversation with the personnel around theories about ‘child development’. In the article we experiment with observation based on posthuman/newmaterial theories. Our specific interests are to explore the complexities around observation by asking; why observations, what do we expect through observation, and what might observation as datamaterial be/become? We are inspired by the Norwegian film “Kitchen Stories” (Salmer fra Kjøkkenet, Hamer, 2003 both as affect/provocation and desire (Koro-Ljungberg & MacLure, 2013. We search for affective bending and messiness (Lather, 2007; Law, 2004 to disturb and challenge observation as dominating paradigm in the field of early years, to break some patterns around the positioning of data material. Artikkelen utfordrer observasjon i barnehagen ut fra at metoden brukes som verktøy for å kartlegge og danne grunnlaget for utvikling av kunnskap om barn.  Observasjon som datamateriale innebærer iakttagelser og nedtegnelser av allerede gitte kategoriseringer om barn og barns utvikling.  Kategorier og kategorisering legger grunnlag for mønster som har i seg ideer om korrespondanse og koherens – sammenhenger som kan bidra til generaliserende kunnskap om barna i barnehagen. Omrisset av artikkelen dreies rundt et forskningsarbeid gjort i en barnehage over en toårs-periode, der vi sammen med de ansatte diskuterer teorier om barn og barns ’utvikling’. Vi bruker posthumane

  17. EST Table: AV404130 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available n (Reed-Steinberg cell-expressed intermediate filament-associated protein) [Tribolium castaneum] 10/08/28 53...78 aa gnl|Amel|GB30360-PB 10/09/10 54 %/199 aa gi|189241063|ref|XP_967018.2| PREDICTED: similar to restin (Reed-Steinberg cell-expres...sed intermediate filament-associated protein) [Tribolium castaneum] FS906662 pg-- ... ...AV404130 pg--0509 10/09/28 54 %/199 aa ref|XP_967018.2| PREDICTED: similar to resti

  18. Tillämpning av IAS 40 i onoterade fastighetsbolag

    OpenAIRE

    Wallin, Fredrik; Nilsson, Karolina; Ericsson, Marina

    2006-01-01

    Enligt IAS 40 – Förvaltningsfastigheter, definieras förvaltningsfastigheter som ”mark eller byggnader eller del av byggnad som innehas i syfte att generera hyresinkomster eller värdestegring”. Onoterade fastighetsbolag i Sverige har idag möjlighet att välja mellan att värdera sina fastigheter till anskaffningsvärde eller verkligt värde. IAS – International Accounting Standards är en internationell redovisningsstandard inom EU som började tillämpas i januari 2001, men blev obligatorisk för bör...

  19. Uranienborg skole : forbedring av skolens uterom i den tette byen

    OpenAIRE

    Thorstensen, Helene

    2011-01-01

    Denne oppgaven fokuserer på skolegårdsforbedring i indre by, og tar for seg Uranienborg skole som et eksempel. Gjennom oppgaven er det jobbet fra et overordnet nivå og ned til et utformingsforslag på et mer detaljert nivå. Det er lagt vekt på hvordan man best mulig kan tilrettelegge når utearealet skolen har rådighet over er begrenset, noe som i dag er en svært aktuell problemstilling i tette byer. Oppgaven består av fire deler: registrering og analyse, teori, referanseprosj...

  20. Minimizing ventricular pacing by a novel atrioventricular (AV) delay hysteresis algorithm in patients with intact or compromised intrinsic AV conduction and different atrial and ventricular lead locations.

    Science.gov (United States)

    Pakarinen, Sami; Toivonen, Lauri

    2013-09-01

    To investigate if an advanced AV search hysteresis (AVSH) algorithm, Ventricular Intrinsic Preference (VIP(™)), reduces the incidence of ventricular pacing (VP) in sinus node dysfunction (SND) with both intact and compromised AV conduction and with intermittent AV block regardless of the lead positions in the right atria and the ventricle. Patients were classified as having intact AV (AVi) conduction if the PR interval was ≤ 210 ms on ECG and 1:1 AV conduction during atrial pacing up to 120 bpm with PR interval ≤ 350 ms. Otherwise the AV conduction was classified as compromised (AVc). Both AVi and AVc patients were randomized to VIP ON or OFF. VIP performed an intrinsic AV conduction search every 30 s for three consecutive atrial cycles with the extension of the sensed and paced AV (SAV/PAV) delays from basic values of 150/200 ms to 300/350 ms. Extended AV intervals were allowed for three cycles when VP occurred before returning to basic AV delays. The primary end-point was %VP at 12 months. Among 389 patients, 30.1% had intact and 69.9% had compromised AV conduction. The mean %VP at 12 months was 9.6% by VIP compared to 51.8% with standard AV settings in patients with AVi (P < 0.0001) and 28.0% versus 78.9% (P < 0.0001) with AVc. With VIP, excessive %VP among most used lead positions was not seen. Conversely, when VIP was off %VP was low only in patients who had leads in the RA septal-RV septal position (23.0%). VIP feature reduces VP both in patients with SND and with intermittent heart block regardless of the lead positions in the right atria and the ventricle.

  1. IceBridge LVIS POS/AV L1B Corrected Position and Attitude Data

    Data.gov (United States)

    National Aeronautics and Space Administration — The IceBridge LVIS POS/AV L1B Corrected Position and Attitude Data (IPPLV1B) data set contains georeferencing data from the Applanix 510 and 610 POS AV systems flown...

  2. IceBridge POS/AV L1B Corrected Position and Attitude Data

    Data.gov (United States)

    National Aeronautics and Space Administration — The IceBridge POS/AV L1B Corrected Position and Attitude (IPAPP1B) data set contains georeferencing data from the Applanix 510 POS AV system flown with the Digital...

  3. UNIPASS for AvSP? A Broader View

    Science.gov (United States)

    Wu, N. Eva

    2001-01-01

    UNIPASS is a general-purpose probabilistic computer program consisting of three major modules, including preprocessor, solver and postprocessor. UNIPASS contains a user-friendly Graphical User Interface (GUI), numerous state-of-the-art probabilistic analysis techniques, a large library of statistical distributions and a function module with a large library of support functions that can easily define any complex limit-state function in a scripting FORTRAN-like syntax format. Its inverse probability analysis and sensitivities analysis capabilities make it a powerful design aid in any product cycle. Its precise numerical analysis engine is accurate enough to push the failure probabilities of a design to well below 10 (exp -50). UNIPASS is equipped with advanced artificial intelligence that is designed to handle systems with an essentially unlimited number of random variables with ease and efficiency. Its modular arrangement allows you to tailor an analysis to the desired level of accuracy and efficiency. The depth and comprehensiveness of UNIPASS are built upon the decades of experience and expertise of industry leaders including Boeing Aircraft, NASA and the DoD. Its rich content also makes UNIPASS a valuable instructional tool for random processes and probabilistic mechanics. The topics include: 1) Reliability in AvSP; 2) Role of UNIPASS in AvSP; and 3) Examples. This paper is in viewgraph form.

  4. Ungdommers opplevelser med overdreven bruk av online-rollespillet World of Warcraft

    DEFF Research Database (Denmark)

    Flaaten, Øivind; Torp, Steffen; Aarseth, Espen

    2010-01-01

    Ungdommers bruk av online-rollespill blir ofte problematisert (Falkner 2007). På bakgrunn av kvalitative intervjuer med ti ungdommer og fem pårørendekontakter beskrives i denne artikkelen ungdommenes opplevelser av online-spillet World of Warcraft (WoW). Denne pilotstudien gir en nyansert...... for konflikt og hjelpeløshet. Helsefremmende arbeid basert på dialog og tidlig intervensjon kan forhindre at online-spilladferd kommer ut av kontroll....

  5. Open Source AV solution supporting In Situ Simulation and Clinical education

    DEFF Research Database (Denmark)

    Simonsen, Eivind Ortind; Pociunas, Gintas; Dahl, Mads Ronald

    2015-01-01

    for a portable AV system for VAD. The system would make use of components widely available and easily replaceable. The developed AV software and coding is contracted to be available as Copyleft Open Source to ensure low cost and a potential continues improvement and expansion of the AV system. Summary of results...... debriefing in a mobile, in situ simulation environment using an AV system constructed from “off the shelf” components and Open Source software....

  6. Förebyggande och rehabilitering av Osgood- Schlatter och Sinding-Larsen−Johanssons syndrom : Utformande av en handbok

    OpenAIRE

    Karenko, Sofia

    2016-01-01

    Detta arbete är ett praktiskt inriktat examensarbete där slutprodukten är en handbok med ett förebyggande och rehabiliterande träningsprogram för Osgood-Schlatter och Sinding-Larsen–Johanssons syndrom (SLJ). Syftet med arbetet är att öka kunskapen om syndromen och utforma ett träningsprogram som kan användas vid förebyggande och rehabiliteringen av dessa. Arbetet bygger på Vilkka och Airaksinens modell för praktiskt inriktat examensarbete som beskrivs i boken Toiminnallinen opinn...

  7. Selvbestemmelse og oppdragelse : en teoretisk analyse av oppdragelsens påvirkning på utviklingen av selvbestemmelse

    OpenAIRE

    Hagen, Marit Svennevig; Haugstvedt, Merete Lehne Rugdal

    2007-01-01

    1) Problemstilling Hensikten med oppgaven er å rette fokus mot oppdragelse som en påvirkningsfaktor på utviklingen av selvbestemmelsen, og hvilken betydning behovstilfredsstillelse har for individets subjektive velvære. Oppdragelse er et populært tema som stadig blir debattert i mediene. Det diskuteres blant annet hvorfor oppdragelse er viktig, hvordan det er mulig å oppdra barn på best mulig måte og hvem som er viktige oppdragere i dagens samfunn. Vår oppgave handler om individets selvbes...

  8. Anvendelser av EPS i vegbygging - med fokus på brofundamentering og myrbro

    OpenAIRE

    Hermansen, Simen

    2012-01-01

    Oppgaven er delt i to deler. Del A Del A gir en innføring i produksjonen av materialet, materialegenskaper, retningslinjer for bruk av materialet og bruksområder. Norge var først ute i verden med bruk av EPS i vegfyllinger i 1972, siden det har teknikken spredd seg verden over. EPS er den letteste av de lette massene som brukes i vegfyllinger med 1 % av egenvekten til konvensjonelle fyllmasser. Materialet avlaster grunn med dårlig bæreevne på en god måte. Senere har flere...

  9. Fremre korsbåndskade og utvikling av sekundær artrose

    OpenAIRE

    Holm, Stine

    2013-01-01

    Oppgaven er en blanding av et litteraturstudie og en kohortestudie. I litteraturstudien har jeg sett på hva fremre korsbånd og artrose er, og hvilke risikofaktorer som kan bidra/progrediere utvikling av artrose hos korsbåndsopererte. I kohortestudien har jeg og veilederen sett på forekomsten av artrose hos korsbåndsopererte- 10-20 år etter ACL rekonstruksjon. Ved hjelp av røntgen og klinisk undersøkelse vurderte vi tidligere korsbåndsopererte og grad av artroseforandringer. Vi så også på hvor...

  10. Finansiering av investeringar i immateriella tillgångar

    OpenAIRE

    Voltaire, Christian; Gillebrink, Valerie

    2008-01-01

    Vid en bedömning av ett kreditärende ser banken till projektets företagsekonomiska förutsättningar. För företag som har immateriella tillgångar som de viktigaste tillgångarna i sin redovisning kan det uppstå problem när de ansöker om kredit hos banker. Detta beror på att immateriella tillgångar inte fungerar på samma sätt som materiella och därigenom tillbringar vag säkerhet för en beviljad kredit. Syftet med denna uppsats är att söka finna vad det är som krävs för att ett tjänsteföretag ska ...

  11. American AV: Edgar Dale and the Information Age Classroom.

    Science.gov (United States)

    Acland, Charles R

    2017-01-01

    This article demonstrates how the influential scholar Edgar Dale, alongside a generation of educational technologists, helped build an essential place for AV materials and pedagogical methods in the American classroom. It also shows that, for decades, the Payne Fund philanthropy supported multimedia research agendas that shaped ideas about teaching and technology, far beyond involvement in their famed studies on motion pictures and children in the 1930s. With his writings and research programs, Dale advanced concepts of media experience and systematicity, which came to be understood as common sense to the information society. In so doing he was a leading contributor to the discursive and ideological structure of our age of technological and informational abundance.

  12. UTVÄRDERING AV UTVALDA SD-WAN PRODUKTER

    OpenAIRE

    Åkerblom, Jacob

    2016-01-01

    Denna jämförelsestudie ämnar att undersöka marknadens leverantörer av nätverksutrustning de- finierade som Software Defined Wide Area Networks(SD-WAN). SD-WAN är en innovativ teknik som applicerar virtualisering och Software defined networking koncept i Wide Area Networks (WAN) för att skapa kostnadseffektiva nätverk. Studien har utförts på företaget Curitiba som idag arbetar med konsulttjänster inom utvalda WAN-optimering och SD-WAN-produkter. Arbetets syfte är att utvärdera SD-WAN-lösningar...

  13. EST Table: AV399395 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV399395 NV120168 10/09/28 100 %/139 aa ref|NP_001037386.1| glyceraldehyde-3-phosph...ate dehydrogenase [Bombyx mori] gb|ABA43638.2| glyceraldehyde-3-phosphate dehydrogenase [Bombyx mori] 10/08/28 81 %/139...id:CAA88697.1 10/09/10 89 %/142 aa AGAP009623-PA Protein|3R:37154051:37155049:1|gene:AGAP009623 10/09/10 79 %/139... aa gnl|Amel|GB14798-PA 10/09/10 84 %/139 aa gi|91088023|ref|XP_974181.1| PREDICTED: similar to glyceraldehyde 3-phosphate dehydrogenase [Tribolium castaneum] DN237090 NV12 ...

  14. En språkfundert kompetansemodell for planlegging av undervisning

    Directory of Open Access Journals (Sweden)

    Erik Knain

    2016-04-01

    Full Text Available I utdanningsvitenskapelig litteratur er ulike former for ”literacy” et vedvarende fokus både teoretisk og empirisk. I engelskspråklig naturfagdidaktisk litteratur brukes betegnelsen ”scientific literacy”. Jeg skisserer i denne artikkelen et planleggingsverktøy for undervisning som bygger på en eksplisitt teoretisk modell for deltakelse gjennom språk. Modellen er bindeledd mellom et generalisert kompetansebegrep og planlegging av undervisning ved at den knytter sammen de didaktiske spørsmålene hva, hvem, hvordan og hvorfor med en modell for funksjonell deltakelse. Modellen er spesielt relevant for et allmenndannende ”naturfag for alle”, men favner også et naturfag som fokuserer på utdanning av framtidas naturvitere. Artikkelen retter seg mot naturfag i skolen, men modellen bør kunne anvendes også i andre skolefag. Modellen peker mot et situert og transformativt kompetansebegrep.Nøkkelord: naturfag , kompetanse , diskurs , deltakelse, undervisning og læringAbstractVarious forms of literacy have long been the focus of educational discourses, not the least in science education where the term “scientific literacy” has been an enduring concern for decades. In this article I describe a tool for designing teaching based on a theoretical perspective on participation through language. The model connects a general conception of competence with the planning of teaching. To do so it drowe on the didactical questions of “what, who, how and why”. The model is particularly relevant in a “science for all” perspective but also for the educating of future science specialists. Although school science is the primary focus in this article, the model should be applicable to other school subjects as well. The model opens for a situated and transformative notion of competence.Keywords: scientific literacy, discourse, participation, teaching and learning

  15. Unga reumatikers upplevelser av sin sjukdom : En kvalitativ intervjustudie av unga kvinnor och män med reumatism

    OpenAIRE

    Blomberg, Catrin; Helle, Johanna

    2015-01-01

    Syftet med den här studien är att få en inblick i hur unga kvinnor och män med reumatismupplever sin sjukdom. Vi vill jämföra dessa upplevelser mellan män och kvinnor genomatt undersöka om det finns skillnader och likheter i återgivna beskrivningar ochupplevelser. Vi vill undersöka om könsspecifika skillnader på upplevelser kringreumatism skulle kunna kopplas till det faktum att fler kvinnor än män diagnostiseras.Vidare vill vi undersöka om samhällets bemötande av individer med reumatism kank...

  16. O tornar-se avó no processo de individuação

    Directory of Open Access Journals (Sweden)

    Caroline Dal Ri Kipper

    Full Text Available O tornar-se avó assinala um período de transição no ciclo de vida familiar, marcado por transformações psíquicas significativas para os avós, caracterizando a quarta individuação. Este trabalho teve como objetivo investigar a experiência de tornar-se avó e sua importância no processo de individuação. Foi utilizado delineamento de estudo de caso coletivo. Onze avós maternas, com idades entre 49 e 66 anos, cujas filhas tiveram seu primeiro filho, responderam a uma entrevista semi-estruturada. Todas as avós tinham tido seus primeiros netos e a entrevista referia-se a sua experiência como avós desses netos. Os dados mostraram que o ser avó é uma fonte de renovação e renascimento. O estudo propiciou que as participantes refletissem sobre seus diferentes papéis familiares: avó, mãe, neta e filha. Os dados sugerem que tornar-se avó possibilita que antigos conflitos sejam repensados, renovando antigos vínculos e desejos, o que permite que a avó dê mais um passo rumo à sua individuação.

  17. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Science.gov (United States)

    Poller, Wolfram C; Dreger, Henryk; Schwerg, Marius; Melzer, Christoph

    2015-01-01

    Optimization of the AV-interval (AVI) in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB) under the pre-programmed AVI. We manually optimized sub-optimal AVI. We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129) and under atrial pacing (AV-pace; n = 31). Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a) normal, b) too long (E/A wave fusion) or c) too short (A wave truncation). In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography. All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%). In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI): 12.6-26.2%). A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms). Given the rate of 19.4% (CI 12.6-26.2%) of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  18. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Directory of Open Access Journals (Sweden)

    Wolfram C Poller

    Full Text Available Optimization of the AV-interval (AVI in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB under the pre-programmed AVI. We manually optimized sub-optimal AVI.We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129 and under atrial pacing (AV-pace; n = 31. Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a normal, b too long (E/A wave fusion or c too short (A wave truncation. In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography.All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%. In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI: 12.6-26.2%. A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms.Given the rate of 19.4% (CI 12.6-26.2% of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  19. Rehabilitering efter dekompression och diskoperation - framställandet av en fysioterapeutisk patientanvisning : Ett beställningsarbete av Tölö sjukhus

    OpenAIRE

    Nyberg, Jasmina

    2016-01-01

    Examensarbetet är ett praktiskt inriktat examensarbete med fokus på rehabiliteringen efter en dekompressions- och diskoperation. Det är ett beställningsarbete av Tölö sjukhus med syftet att framställa en fysioterapeutisk patientanvisning. Önskemål från uppdragsgivare var att utforma en tydlig patientanvisning för ryggopererade bestående av skriftliga instruktioner angående postoperativ rehabilitering i form av vardagliga aktiviteter, fysisk aktivitet, ryggens viloställningar, vi...

  20. ADVANCED VITRIFICATION SYSTEM (RIC AVS) RESEARCH AND DEVELOPMENT PROJECT

    International Nuclear Information System (INIS)

    Powell, J.R.; Reich, M.

    2003-01-01

    The objective of this AVS testing program is to use bench-scale test equipment to produce a vitrified product at maximum waste loading from the specified AZ-101 waste simulant and conduct a TTT analysis using laboratory scale melts to show compliance with the DOE Waste Acceptance Product Specifications for Vitrified High-Level Waste Forms (WAPS). The vitrified product complies with the following WAPS. A borosilicate glass with a waste loading of 60.9-wt% was produced from a slurry feed of AZ101 simulant. Glass durability testing, glass characterization testing, and testing methodology were performed in accordance with the Department of Energy approved Test Plan. The glass has two crystalline phases and good uniformity of composition. The Product Consistency Test on the 6 location-specific samples are at least 1 to 2 orders of magnitude below the mean PCT results for the EA glass. Standard deviations were less than 10% of measured values. The glass transition temperature averaged 658 ± 9 C. A TTT diagram was produced. There was measured cesium loss of about 2%, and compliance with the Universal Treatment Standards

  1. Geologic and Mineralogic Mapping of Av-6 (Gegania) and Av-7 (Lucaria) Quadrangles of Asteroid 4 Vesta

    Science.gov (United States)

    Nathues, A.; Le Corre, L.; Reddy, V.; De Sanctis, M. C.; Williams, D. A.; Garry, W. B.; Yingst, R. A.; Jaumann, R.; Ammannito, E.; Capaccioni, F.; Preusker, F.; Palomba, E.; Roatsch, T.; Tosi, F.; Zambon, F.; Pieters, C. M.; Russell, C. T.; Raymond, C. A.

    2012-04-01

    NASA's Dawn spacecraft arrived at the asteroid 4 Vesta in July 2011 and is now collecting imaging and spectroscopic data during its one-year orbital mission. The maps we present are based on information obtained by the Visible and Infrared Mapping Spectrometer VIR-MS and the multi-color Framing Camera FC. VIR covers the wavelength range between 0.25 to 5.1 µm while FC covers the range 0.4 to 1.0 µm. The VIR instrument has a significant higher spectral resolution than FC but the latter achieves higher spatial resolution data. As part of the geological and mineralogical analysis of the surface, a series of 15 quadrangles have been defined covering the entire surface of Vesta. We report about the mapping results of quadrangle Av-6 (Gegania) and Av-7 (Lucaria). The Gegania quadrangle is dominated by old craters showing no ejecta blankets and rays while several small fresh craters do. The most obvious geologic features are a set of equatorial troughs, a group of three ghost craters of similar diameter (~57 km), an ejecta mantling of the Gegania crater and three smaller craters showing bright and dark ejecta rays. The quadrangle contains two main geologic units: 1) the northern cratered trough terrain and 2) the equatorial ridge and trough terrain. The quadrangle shows moderate variation in Band II center wavelength and Band II depth. FC color ratio variations of some recent craters and their ejecta are linked to the bright and dark material. The bright material is possibly excavated eucritic material while the dark material could be remnants of a CM2 impator(s) or an excavated subsurface layer of endogenic origin. The most prominent geologic features in the Lucaria quadrangle are the 40 km long hill Lucaria Tholus, a set of equatorial troughs, some relatively fresh craters with bright and dark material and mass wasting. The quadrangle contains three main geologic units: 1) the northern cratered trough terrain, 2) the equatorial ridge and trough terrain, and 3) the

  2. Skatte- og konkurransemessige utfordringer i delingsøkonomien : en studie av Airbnb

    OpenAIRE

    Monsen, Jørgen Tvedt; Gundersen, Preben Holme

    2017-01-01

    Delingsøkonomien har vært gjenstand for bemerkelsesverdig vekst i nyere tid. Delingskonseptet omfatter en rekke økonomiske aktiviteter som via en plattform tilrettelegger for effektiv kommunikasjon mellom tilbydere og etterspørrere av underutnyttede ressurser. Gjennom å forsyne overnattingsmarkedet med personers ledige kapasitet av boenheter, har Airbnb blitt en verdensledende delingsaktør. Fremveksten av delingsøkonomien har bidratt til inntektsmuligheter for tilbydere, samtid...

  3. Dialogmøte om teknologi for trenging av fisk i merd

    OpenAIRE

    Henriksen, Kristian; Sunde, Leif Magne; Digre, Hanne; Svendsen, Erik; Rundtop, Per; Erikson, Ulf Gøran

    2013-01-01

    SINTEF Fiskeri og havbruk arrangerte den 19. mars 2013, i samarbeid med Fiskeri- og havbruksnæringens forskningsfond (FHF), et dialogmøte med fokus på teknologi for trenging av fisk i merd. Under møtet ble status for gjeldene teknologi og operasjoner for trenging av fisk i merd, samt resultater fra forskningsprosjekter tilknyttet trengeprosessen, presentert. Videre ble det samlet innspill om utfordringer tilknyttet trenging av fisk i produksjons- og ventemerd fra oppdrettsbedrifter, leverandø...

  4. IAS 40 i ljuset av ägarförhållanden : Värdering av förvaltningsfastigheter i börsnoterade respektive statliga bolag

    OpenAIRE

    Klarin, Olof; Sandell, Johan

    2010-01-01

    Sammanfattning: Redovisningen av förvaltningsfastigheter enligt IAS 40 har tidigare beskrivits i ett stort antal olika vetenskapliga alster. Merparten av dessa har dock tittat på börsnoterade bolag men det finns även andra företag som tillämpar IAS-reglerna. En grupp företag som gör det är de bolag som ägs av svenska staten. Ett av målen med IFRS är att skapa jämförbarhet och då bör inte ägarformen ha någon betydelse för redovisning och värdering. Denna studies syfte är därför att skapa insik...

  5. Utveckling av en Windows Service för databassynkronisering med Microsoft Sync Framework

    OpenAIRE

    Vik, Christian

    2011-01-01

    Detta examensarbete utfördes åt Hogia Ferry Systems. Examensarbetet behandlar utvecklingen av ett synkroniseringsverktyg för databaserna som företagets produkter använder. Lösningen kommer att ersätta ett befintligt system för synkronisering. Fokus för detta projekt ligger på utvecklingen av en synkroniseringstjänst för multipla typer av databaser. Databaserna som stöds är SQL Server, Informix samt Oracle. För utvecklingen av själva synkroniseringen har Microsoft Sync Framework använts. F...

  6. Effekt av å benytte sosiale medier i kampanjer for å fremme sunne levevaner

    OpenAIRE

    Strømme, Hilde

    2014-01-01

    Hensikten med denne systematiske oversikten er å svare på spørsmålet: Hva er effekten av å benytte sosiale medier i kampanjer for å påvirke holdninger, kunnskap og atferd knyttet til sunne levevaner? Metode: Systematiske søk ble gjort i 11 bibliografiske baser. Tilleggssøk ble gjort i Google Scholar. Utvelgelse og vurdering av publikasjoner ble gjort av to personer uavhengig av hverandre. Risiko for systematiske feil ble vurdert med sjekklisten til Cochrane Effective Practice and Organisation...

  7. Frihet, fantasi og utfoldelse: En kvalitativ studie av estetiske arbeidsformer i lærerutdanningene

    Directory of Open Access Journals (Sweden)

    Borghild Brekke

    2017-10-01

    Full Text Available Artikkelen undersøker hva slags forståelse lærerutdannere og lærerstudenter har av estetiske arbeidsformer i undervisningen i lærerutdanningene. Studien er en kvalitativ intervjuundersøkelse blant lærerutdannere og lærerstudenter ved en norsk lærerutdanningsinstitusjon. I lys av danningsteoretisk og didaktisk teori, finner studien at lærerutdannere og lærerstudenters forståelse av estetiske arbeidsformer i undervisningen er kjennetegnet av «frihet» som fravær av tvang og fasit i arbeid med lærestoffet, «fantasi» som bruk av forestillingsevnen slik at kunnskapen blir personlig, og «utfoldelse» som sosialisering inn i et fellesskap gjennom tilbakemeldinger på egen atferd. Til sammen kan informantenes forståelse av de tre aspektene sies å fremheve viktigheten av å utvikle de lærendes autonomi. Artikkelen gir et bidrag til undervisningspraksis i lærerutdanningene, gjennom å gi eksempler på hva estetiske arbeidsformer kan være i en slik sammenheng. Avslutningsvis drøftes funnene opp mot samtidige politiske begrunnelser for bruk av estetiske arbeidsformer i utdanningene.

  8. Samtalegrupper for personer med Aspergers syndrom. En kvalitativ studie av hva fagpersoner forteller om planlegging, gjennomføring og effekt av samtalegrupper for personer med Aspergers syndrom

    OpenAIRE

    Jensen, Øyvind

    2014-01-01

    Denne oppgaven er skrevet ut fra problemstillingen: Hvordan beskriver fagpersoner planlegging, gjennomføring og effekt av samtalegrupper for personer med Aspergers syndrom? Den belyser teori om Aspergers syndrom, effekt av samtalegrupper samt andre viktige forhold i tilknytning til samtalegruppe, som kommunikasjon, veiledning og psykoedukasjon. Fire informanter fra nettverket «Nasjonalt fagutviklingsnettverk om psykoedukative grupper for personer med Aspergers syndrom» ble intervjuet, ...

  9. Hvor moralsk tenker fotballspillere? – en empirisk studie av toppfotball

    Directory of Open Access Journals (Sweden)

    Lars Tore Ødegård

    2015-11-01

    Full Text Available Det er en utbredt oppfatning at det økende prestasjonskravet i toppfotball fører til en svekkelse av moral og fair play-holdninger. Men hvordan tenker toppfotballspillere i forhold til ulike dilemmaer som oppstår på banen, og er det forskjeller mellom toppfotballspillere og spillere på lavere nivå?  For å avklare dette gjennomførte vi en empirisk undersøkelse der vi intervjuet spillere og trener i én toppklubb og én breddeklubb. Vi var interessert i to hovedproblemstillinger:  1 Hva tenker fotballspillere på ulike prestasjonsnivå om etikk og moralske dilemmaer i fotball? 2 Hvilke faktorer påvirker spillerne, direkte og indirekte, i deres vurderinger og handlinger? Resultatene fra undersøkelsen viser at det er store forskjeller mellom de to prestasjonsnivåene. Spillerne på breddenivået føler generelt et større ansvar for å opptre ærlig på banen enn hva som er tilfelle på toppnivået. Vi fant 4 spesifikke faktorer i toppfotballen som bidrar til umoralsk opptreden. For det første opplever spillerne en forventning om at de prioriterer resultat foran fair play. For det andre bidrar tilstedeværelsen av supportere på kamper til en slik prioritering. For det tredje vil handlinger som er i strid med fair play signaliseres som akseptable internt i miljøet, selv om de ofte signaliseres som uakseptable overfor media og omverdenen. For det fjerde kan spillere oppleve det som vanskelig å gå i mot trenerens oppfordringer til en pragmatisk og resultatfokusert opptreden.Nøkkelord: moral, etikk, fair play, footballEnglish summary: How morally do football players think? – an empirical study of moral dilemmas in elite footballIt is a common view that the increasing focus on achievement and success in elite football leads to a weakening of moral and fair play attitudes. But how do elite players think and what do they think about different dilemmas that appear on the field, and is there a difference between elite players and lower

  10. Elevers oppfatning av lærers tilbakemeldingspraksis: om sammenheng mellom graden av VfL-praksis og elevenes opplevde nytte av lærers skriftlige tilbakemeldinger i skriftlig norsk

    Directory of Open Access Journals (Sweden)

    Harald Eriksen

    2017-11-01

    Full Text Available Formålet med denne studien var å undersøke elevers oppfatninger av norsklærerens tilbakemeldingspraksis i skriftlig norsk. På bakgrunn av omfattende internasjonal forskning innen feltet ‘Vurdering for læring’ (VfL er det i denne studien utviklet teoridrevne hypoteser som testes ved å analysere et datasett fra to videregående skoler. Hypotesene er at elevene oppfatter lærers tilbakemelding som mer nyttig hvis den 1 retter seg mot målet med opplæringen, 2 gir elevene informasjon via en forklaring eller instruks om hvordan de skal komme nærmere målet og 3 at lærer legger til rette for bruk av tilbakemeldingen. Strukturell likningsmodellering (SEM av resultater fra en spørreundersøkelse blant elever (N = 213 er brukt som metode til å estimere forholdet mellom de fire latente variablene kriterier, forklaring, bruk og nytte (avhengig variabel. SEM er brukt fordi metoden egner seg til å undersøke sammenhenger i komplekse datasett. Funn er at elevene oppfatter at hvis lærer forklarer hvordan de kan forbedre seg, er dette positivt statistisk assosiert med opplevd nytte. Et mer overraskende funn er at lærerens tilrettelegging for bruk av tilbakemeldinger ikke er signifikant assosiert med opplevd nytte. Resultatene blir diskutert i artikkelen.

  11. Effects of AV-delay optimization on hemodynamic parameters in patients with VDD pacemakers.

    Science.gov (United States)

    Krychtiuk, Konstantin A; Nürnberg, Michael; Volker, Romana; Pachinger, Linda; Jarai, Rudolf; Freynhofer, Matthias K; Wojta, Johann; Huber, Kurt; Weiss, Thomas W

    2014-05-01

    Atrioventricular (AV) delay optimization improves hemodynamics and clinical parameters in patients treated with cardiac resynchronization therapy and dual-chamber-pacemakers (PM). However, data on optimizing AV delay in patients treated with VDD-PMs are scarce. We, therefore, investigated the acute and chronic effects of AV delay optimization on hemodynamics in patients treated with VDD-PMs due to AV-conduction disturbances. In this prospective, single-center interventional trial, we included 64 patients (38 men, 26 women, median age: 77 (70-82) years) with implanted VDD-PM. AV-delay optimization was performed using a formula based on the surface electrocardiogram (ECG). Hemodynamic parameters (stroke volume (SV), cardiac output (CO), heart rate (HR), and blood pressure (BP)) were measured at baseline and follow-up after 3 months using impedance cardiography. Using an ECG formula for AV-delay optimization, the AV interval was decreased from 180 (180-180) to 75 (75-100) ms. At baseline, AV-delay optimization led to a significant increase of both SV (71.3 ± 15.8 vs. 55.3 ± 12.7 ml, p AV delay vs. nominal AV interval, respectively) and CO (5.1 ± 1.4 vs. 3.9 ± 1.0 l/min, p AV-delay optimization in patients treated with VDD-PMs exhibits immediate beneficial effects on hemodynamic parameters that are sustained for 3 months.

  12. Litterær kompetanse - portrett av tre lesarar

    Directory of Open Access Journals (Sweden)

    Hallvard Kjelen

    2015-08-01

    Full Text Available Artikkelen drøfter eit sentralt problemfelt innom litteraturdidaktikken, nemleg tilhøvet mellom litterær lesing som fagleg kompetanse og litterær lesing som oppleving. Problemfeltet er særleg knytt til Louise Rosenblatts arbeid. Ho viser ved hjelp av omgrepa efferent og estetisk lesing korleis det er ei utfordring for litteraturlæraren å utvikle ei litteraturundervisning som i tilstrekkeleg grad tek omsyn til kjensler og røynsler. I ein litteraturteoretisk kontekst er subjektive responsar på litterære tekstar irrelevante, men i ein litteraturdidaktisk kontekst er subjektive responsar høgst relevante. Denne artikkelen bidrar inn i diskusjon-en mellom anna ved å trekkje inn meir empirisk basert litteraturteori som referanseramme. Artikkelen presenterer tre lesarars litterære responsar, og viser korleis kunnskap om individuelle lesarresponsar kan vere utgangspunkt for ei litteraturundervisning som balanserer ei fagleg tilnærming til litteratur opp mot ei meir opplevingsbasert tilnærming.Emneord: Litteraturundervisning, litterær kompetanse, empirisk litteraturteori, lesarresponsAbstractThe article discusses a key issue in literature didactics, namely the relation between literary reading as an academic competence, and literary reading as an experience. The discussion draws heavily on Louise Rosenblatt’s work. By using the concepts efferent and aesthetic reading, she shows how it is a challenge for the teacher of literature to develop literature teaching that adequately takes emotions and experience into account. In a literature-theoretical context, subjective responses to literary texts are irrelevant; but in a didactics context, the subjective responses are highly relevant.  This article contributes to the discussion by bringing in a more empirically based literature theory as a frame of reference. The article presents three readers’ literary responses, and shows how knowledge of individual reader responses can be the basis for

  13. AVS/Express (application visualization system) user's guide

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Katsumi [Research Organization for Information Science Technology, Tokai, Ibaraki (Japan); Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-09-01

    Computer and network environment for image processing has been developed and maintained under the course of establishing a distributed processing environment by the information system operating division. We introduced a server for image processing, AVS/Express for image processing software and Stereo viewing system. This report summarizes the information to use AVS/Express efficiently in the computer environment for image processing. (author)

  14. Pilot Implementation and Preliminary Evaluation of START:AV Assessments in Secure Juvenile Correctional Facilities.

    Science.gov (United States)

    Desmarais, Sarah L; Sellers, Brian G; Viljoen, Jodi L; Cruise, Keith R; Nicholls, Tonia L; Dvoskin, Joel A

    2012-01-01

    The Short-Term Assessment of Risk and Treatability: Adolescent Version (START:AV) is a new structured professional judgment guide for assessing short-term risks in adolescents. The scheme may be distinguished from other youth risk assessment and treatment planning instruments by its inclusion of 23 dynamic factors that are each rated for both vulnerability and strength. In addition, START:AV is also unique in that it focuses on multiple adverse outcomes-namely, violence, self-harm, suicide, unauthorized leave, substance abuse, self-neglect, victimization, and general offending-over the short-term (i.e., weeks to months) rather than long-term (i.e., years). This paper describes a pilot implementation and preliminary evaluation of START:AV in three secure juvenile correctional facilities in the southern United States. Specifically, we examined the descriptive characteristics and psychometric properties of START:AV assessments completed by 21 case managers on 291 adolescent offenders (250 boys and 41 girls) at the time of admission. Results provide preliminary support for the feasibility of completing START:AV assessments as part of routine practice. Findings also highlight differences in the characteristics of START:AV assessments for boys and girls and differential associations between the eight START:AV risk domains. Though results are promising, further research is needed to establish the reliability and validity of START:AV assessments completed in the field.

  15. Association of temporary complete AV block and junctional ectopic tachycardia after surgery for congenital heart disease.

    Science.gov (United States)

    Paech, Christian; Dähnert, Ingo; Kostelka, Martin; Mende, Meinhardt; Gebauer, Roman

    2015-01-01

    Junctional ectopic tachycardia (JET) is a postoperative complication with a mortality rate of up to 14% after surgery for congenital heart disease. This study evaluated the risk factors of JET and explored the association of postoperative temporary third degree atrioventricular (AV) block and the occurrence of JET. Data were collected retrospectively from 1158 patients who underwent surgery for congenital heart disease. The overall incidence of JET was 2.8%. Temporary third degree AV block occurred in 1.6% of cases. Permanent third degree AV block requiring pacemaker implantation occurred in 1% of cases. In all, 56% of patients with JET had temporary AV block (P AV block (P = 0.56). temporary third degree AV block did not suffer from JET. A correlation between temporary third degree AV block and postoperative JET could be observed. The risk factors identified for JET include younger age groups at the time of surgery, longer aortic cross clamping time and surgical procedures in proximity to the AV node.

  16. A-V Fistulae from Arrow Injuries: A Report of Two Cases ...

    African Journals Online (AJOL)

    Of these, one involved the temporal vessels, which led to a temporo-temporal A-V fistula causing the patient continuous noisy headache. The late complication was only recognized about two years post injury. Another arrow shot injury involved femoral vessels and resulted in femoro-femoral A-V fistula, which came to be ...

  17. InterProScan Result: AV401888 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV401888 AV401888_3_ORF1 2F04E8AA567F7BCF PANTHER PTHR11511 INSECT HEMOCYANIN-RELAT...ED 1.5e-119 T IPR013788 Arthropod hemocyanin/insect LSP Molecular Function: oxygen transporter activity (GO:0005344)|Biological Process: transport (GO:0006810) ...

  18. InterProScan Result: AV402282 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV402282 AV402282_2_ORF1 D1F0DCC6A8296985 PANTHER PTHR11511 INSECT HEMOCYANIN-RELAT...ED 5e-97 T IPR013788 Arthropod hemocyanin/insect LSP Molecular Function: oxygen transporter activity (GO:0005344)|Biological Process: transport (GO:0006810) ...

  19. InterProScan Result: AV399740 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV399740 AV399740_3_ORF2 7A42A41D4F3F6388 PFAM PF00067 p450 1.2e-19 T IPR001128 Cytochrome P450 Molecular... Function: monooxygenase activity (GO:0004497)|Molecular Function: iron ion binding (GO:0005506)|Molecular... Function: electron carrier activity (GO:0009055)|Molecular Function: heme binding (GO:0020037) ...

  20. InterProScan Result: AV399409 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 429 Baculovirus LEF-11 Biological Process: viral infectious cycle (GO:0019058)|Biological Process: regulation of transcription (GO:0045449) ... ...AV399409 AV399409_1_ORF2 07DC81A7C7B2FA42 PFAM PF06385 Baculo_LEF-11 3e-33 T IPR009

  1. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family

    DEFF Research Database (Denmark)

    Nilsson, Stefan K; Lookene, Aivar; Beckstead, Jennifer A

    2007-01-01

    Apolipoprotein A-V is a potent modulator of plasma triacylglycerol levels. To investigate the molecular basis for this phenomenon we explored the ability of apolipoprotein A-V, in most experiments complexed to disks of dimyristoylphosphatidylcholine, to interact with two members of the low density...... lipoprotein receptor family, the low density lipoprotein receptor-related protein and the mosaic type-1 receptor, SorLA. Experiments using surface plasmon resonance showed specific binding of both free and lipid-bound apolipoprotein A-V to both receptors. The binding was calcium dependent and was inhibited......, apolipoprotein A-V (Arg210Glu/Lys211Gln), showed decreased binding to heparin and decreased ability to bind the low density lipoprotein receptor-related protein. Association of apolipoprotein A-V with the low density lipoprotein receptor-related protein or SorLA resulted in enhanced binding of human chylomicrons...

  2. In vivo retention of18F-AV-1451 in corticobasal syndrome.

    Science.gov (United States)

    Smith, Ruben; Schöll, Michael; Widner, Håkan; van Westen, Danielle; Svenningsson, Per; Hägerström, Douglas; Ohlsson, Tomas; Jögi, Jonas; Nilsson, Christer; Hansson, Oskar

    2017-08-22

    To study the usefulness of 18 F-AV-1451 PET in patients with corticobasal syndrome (CBS). We recruited 8 patients with CBS, 17 controls, 31 patients with Alzheimer disease (AD), and 11 patients with progressive supranuclear palsy (PSP) from the Swedish BioFINDER study. All patients underwent clinical assessment, 18 F-AV-1451 PET, MRI, and quantification of β-amyloid pathology. A subset of participants also underwent 18 F-FDG-PET. In the 8 patients with CBS, 6 had imaging findings compatible with the corticobasal degeneration pathology and 2 with typical AD pathology. In the 6 patients with CBS without typical AD pathology, there were substantial retentions of 18 F-AV-1451 in the motor cortex, corticospinal tract, and basal ganglia contralateral to the most affected body side. These patients could be clearly distinguished from patients with AD dementia or PSP using 18 F-AV-1451. However, cortical atrophy was more widespread than the cortical retention of 18 F-AV1451 in these CBS cases, and cortical AV-1451 uptake did not correlate with cortical thickness or glucose hypometabolism. These results are in sharp contrast to AD dementia, where 18 F-AV-1451 retention was more widespread than cortical atrophy, and correlated well with cortical thickness and hypometabolism. Patients with CBS without typical AD pathology exhibited AV-1451 retention in the motor cortex, corticospinal tract, and basal ganglia contralateral to the affected body side, clearly different from controls and patients with AD dementia or PSP. However, cortical atrophy measured with MRI and decreased 18 F-fluorodeoxyglucose uptake were more widespread than 18 F-AV-1451 uptake and probably represent earlier, yet less specific, markers of CBS. This study provides Class III evidence that 18 F-AV-1451 PET distinguishes between CBS and AD or PSP. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  3. [18F]AV-1451 tau positron emission tomography in progressive supranuclear palsy.

    Science.gov (United States)

    Whitwell, Jennifer L; Lowe, Val J; Tosakulwong, Nirubol; Weigand, Stephen D; Senjem, Matthew L; Schwarz, Christopher G; Spychalla, Anthony J; Petersen, Ronald C; Jack, Clifford R; Josephs, Keith A

    2017-01-01

    The [ 18 F]AV-1451 positron emission tomography ligand allows the in vivo assessment of tau proteins in the brain. It shows strong binding in Alzheimer's dementia, but little is known about how it performs in progressive supranuclear palsy, a primary 4R tauopathy. The objectives of this study were to determine whether [ 18 F]AV-1451 uptake can be observed in progressive supranuclear palsy and to characterize the regional distribution when compared with controls and Alzheimer's dementia. [ 18 F]AV-1451 positron emission tomography was performed in 10 patients with probable progressive supranuclear palsy. These patients were age- and gender-matched to 50 controls and 10 Alzheimer's dementia patients who had undergone identical [ 18 F]AV-1451 imaging. Regional comparisons of [ 18 F]AV-1451 uptake were performed across the whole brain using region-of-interest and voxel-level analyses, and correlations between regional [ 18 F]AV-1451 and the progressive supranuclear palsy rating scale were assessed. An elevated [ 18 F]AV-1451 signal was observed in progressive supranuclear palsy when compared with controls in the pallidum, midbrain, dentate nucleus of the cerebellum, thalamus, caudate nucleus, and frontal regions. Signal in the cerebellar dentate and pallidum were also greater in progressive supranuclear palsy when compared with Alzheimer's dementia. Conversely, the [ 18 F]AV-1451 signal across the cortex was higher in Alzheimer's dementia when compared with progressive supranuclear palsy. The [ 18 F]AV-1451 signal in a number of regions correlated with the progressive supranuclear palsy rating scale. Progressive supranuclear palsy is associated with an elevated [ 18 F]AV-1451 signal in a characteristic and distinct regional pattern that correlates with disease severity and differs from the patterns observed in Alzheimer's dementia. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  4. BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling.

    Science.gov (United States)

    Saxon, Jacob G; Baer, Daniel R; Barton, Julie A; Hawkins, Travis; Wu, Bingruo; Trusk, Thomas C; Harris, Stephen E; Zhou, Bin; Mishina, Yuji; Sugi, Yukiko

    2017-10-01

    Distal outgrowth, maturation and remodeling of the endocardial cushion mesenchyme in the atrioventricular (AV) canal are the essential morphogenetic events during four-chambered heart formation. Mesenchymalized AV endocardial cushions give rise to the AV valves and the membranous ventricular septum (VS). Failure of these processes results in several human congenital heart defects. Despite this clinical relevance, the mechanisms governing how mesenchymalized AV endocardial cushions mature and remodel into the membranous VS and AV valves have only begun to be elucidated. The role of BMP signaling in the myocardial and secondary heart forming lineage has been well studied; however, little is known about the role of BMP2 expression in the endocardial lineage. To fill this knowledge gap, we generated Bmp2 endocardial lineage-specific conditional knockouts (referred to as Bmp2 cKO Endo ) by crossing conditionally-targeted Bmp2 flox/flox mice with a Cre-driver line, Nfatc1 Cre , wherein Cre-mediated recombination was restricted to the endocardial cells and their mesenchymal progeny. Bmp2 cKO Endo mouse embryos did not exhibit failure or delay in the initial AV endocardial cushion formation at embryonic day (ED) 9.5-11.5; however, significant reductions in AV cushion size were detected in Bmp2 cKO Endo mouse embryos when compared to control embryos at ED13.5 and ED16.5. Moreover, deletion of Bmp2 from the endocardial lineage consistently resulted in membranous ventricular septal defects (VSDs), and mitral valve deficiencies, as evidenced by the absence of stratification of mitral valves at birth. Muscular VSDs were not found in Bmp2 cKO Endo mouse hearts. To understand the underlying morphogenetic mechanisms leading to a decrease in cushion size, cell proliferation and cell death were examined for AV endocardial cushions. Phospho-histone H3 analyses for cell proliferation and TUNEL assays for apoptotic cell death did not reveal significant differences between control and

  5. Jämförelse av vertikala accelerationer av järnvägsbroar för höghastighetståg.

    OpenAIRE

    Shoaibi, Martin

    2014-01-01

    Under de senaste decennierna parallellt med klimatdiskussionen har det vuxit fram ett stort intresse för höghastighetståg och en förbättrad infrastruktur i Sverige. I delar av Europa men speciellt i Kina och Japan har utvecklingen av höghastighetståg fått ett enormt lyft. Ett problem vid höjda tåghastigheter är att broarna vid en kombination av låg massa och låg egenfrekvens riskerar att orsaka resonans och höga accelerationsnivåer vid passage. Ballastspår är namnet för det traditionella järn...

  6. Nodal recovery, dual pathway physiology, and concealed conduction determine complex AV dynamics in human atrial tachyarrhythmias.

    Science.gov (United States)

    Masè, Michela; Glass, Leon; Disertori, Marcello; Ravelli, Flavia

    2012-11-15

    The genesis of complex ventricular rhythms during atrial tachyarrhythmias in humans is not fully understood. To clarify the dynamics of atrioventricular (AV) conduction in response to a regular high-rate atrial activation, 29 episodes of spontaneous or pacing-induced atrial flutter (AFL), covering a wide range of atrial rates (cycle lengths from 145 to 270 ms), were analyzed in 10 patients. AV patterns were identified by applying firing sequence and surrogate data analysis to atrial and ventricular activation series, whereas modular simulation with a difference-equation AV node model was used to correlate the patterns with specific nodal properties. AV node response at high atrial rate was characterized by 1) AV patterns of decreasing conduction ratios at the shortening of atrial cycle length (from 236.3 ± 32.4 to 172.6 ± 17.8 ms) according to a Farey sequence ordering (conduction ratio from 0.34 ± 0.12 to 0.23 ± 0.06; P AV block patterns occurring during regular atrial tachyarrhythmias. The characterization of AV nodal function during different AFL forms constitutes an intermediate step toward the understanding of complex ventricular rhythms during atrial fibrillation.

  7. Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation.

    Science.gov (United States)

    Shin, Dong-In; Merx, Marc W; Meyer, Christian; Kirmanoglou, Kiriakos; Hellhammer, Katharina; Ohlig, Jan; Katsani, Dimitra; Zeus, Tobias; Westenfeld, Ralf; Eickholt, Christian; Linke, Axel; Kelm, Malte

    2015-10-01

    Development of AV-block is a frequent complication associated with transcatheter aortic valve implantation (TAVI). To date little is known about the predictive value of the HV-interval prior to TAVI with respect to the risk of AV-block development. HV-interval was determined in 25 consecutive elderly patients with severe aortic valve stenosis (AS) before and immediately after TAVI. All patients subsequently underwent TAVI and 8 of these 25 patients (32%) developed complete AV-block during the TAVI procedure requiring permanent pacemaker implantation. Six of these 8 patients (75%) had marked HV prolongation (>54 ms). Pre-procedural HV-interval was significantly prolonged in the subgroup developing complete AV-block (62.1 ms±13.0 vs 49.2 ms±12.9; P=0.029). Prolongation of the HV-interval above 54 ms was associated with a higher rate of complete AV-block (sensitivity 75.0%, specificity 77.8%, P=0.01). HV-interval was prolonged in approximately one third of our elderly patients with aortic valve stenosis and associated with a high rate of complete AV-block following TAVI. HV-interval is easily obtained during TAVI screening procedures, thus facilitating identification of patients at risk for complete AV-block due to TAVI and consequently enabling bespoke risk management.

  8. Sampling method, storage and pretreatment of sediment affect AVS concentrations with consequences for bioassay responses

    Energy Technology Data Exchange (ETDEWEB)

    Lange, H.J. de [Aquatic Ecology and Water Quality Management Group, Wageningen University, Wageningen University and Research Centre, P.O. Box 8080, 6700 DD, Wageningen (Netherlands); Centre for Ecosystem Studies, Alterra, Wageningen University and Research Centre, P.O. Box 47, 6700 AA, Wageningen (Netherlands)], E-mail: marieke.delange@wur.nl; Griethuysen, C. van; Koelmans, A.A. [Aquatic Ecology and Water Quality Management Group, Wageningen University, Wageningen University and Research Centre, P.O. Box 8080, 6700 DD, Wageningen (Netherlands)

    2008-01-15

    Sediment treatment and sediment storage may alter sediment toxicity, and consequently biotic response. Purpose of our study was to combine these three aspects (treatment-toxicity-biotic response) in one integrated approach. We used Acid Volatile Sulfide (AVS) concentrations as a proxy of the disturbance of the sediment. AVS and Simultaneously Extracted Metal (SEM) concentrations were compared to bioassay responses with the freshwater benthic macroinvertebrate Asellus aquaticus. Storage conditions and sediment treatment affected AVS but not SEM levels. AVS can be used as a proxy for sediment disturbance. The best way to pretreat the sediment for use in a bioassay in order to maintain initial AVS conditions was to sample the sediment with an Ekman grab, immediately store it in a jar without headspace, and freeze it as soon as possible. In a survey using seven different sediments, bioassay responses of A. aquaticus were correlated with SEM and AVS characteristics. - Change in AVS is a good proxy for sediment disturbance and combined with SEM it can be used as a suitable predictor for biotic effects of sediment contamination.

  9. Mot en professionalisering av det pedagogiska ledarskapet vid Umeå universitet

    Directory of Open Access Journals (Sweden)

    Sven B Eriksson

    2013-01-01

    Full Text Available Det pedagogiska ledarskapet inom högre utbildning fokuseras allt mer. Det understryks genom att flera lärosäten föreskriver såväl att pedagogiska ledare ska finnas på olika nivåer, som vilka övergripande uppgifter dessa ska ha. Denna artikel är ett resultat av en fallstudie av hur de tillägnade kunskaperna och färdigheterna från kursen Pedagogiskt ledarskap, en kurs för målgruppen studierektorer/pedagogiskt ansvariga eller motsvarande arrangerad av Universitetspedagogiskt centrum, har bidragit till deltagarnas professionalisering av det pedagogiska ledarskapet ett år efter kursens slut. Fallstudien genomfördes genom gruppintervjuer. Respondenterna uttryckte att de fått ett stärkt självförtroende i rollen som pedagogiska ledare samt att kursen bidrog till en professionalisering av rollen som pedagogiska ledare genom att stärka identiteten, att skapa en början till en handlingsetik bestående av delvis delade värderingar kring det pedagogiska ansvaret samt ge utbildning och träning i färdigheter som har sin grund i teoretisk kunskap. Kursen Pedagogiskt ledarskap ger därmed ett stöd i en process mot en professionalisering av det pedagogiska ledarskapet vid Umeå universitet.

  10. Nye estimater av organdoser til barn ved datatomografi (CT) utført på 1990-tallet i Norge

    OpenAIRE

    Toft, Benthe

    2013-01-01

    Bakgrunn: Bruk av datatomografi (CT) har økt i Norge de siste ti årene og står nå for 80 % av befolkningsdosen fra medisinsk bruk av stråling. Det er usikkerhet rundt risikoen ved bruk av ioniserende stråling, særlig knyttet til CT av barn og unge. En stor internasjonal studie (EPI-CT-prosjektet) tar sikte på å skaffe økt kunnskap om risiko for leukemi og hjernekreft forbundet med CT-undersøkelser hos barn og unge. Studiens hensikt: Karlegging av organdoser til barn ved CT-undersøkelser p...

  11. Subcortical18F-AV-1451 binding patterns in progressive supranuclear palsy.

    Science.gov (United States)

    Cho, Hanna; Choi, Jae Yong; Hwang, Mi Song; Lee, Seung Ha; Ryu, Young Hoon; Lee, Myung Sik; Lyoo, Chul Hyoung

    2017-01-01

    Accumulation of cortical and subcortical tau pathology is the primary pathological substrate for progressive supranuclear palsy (PSP). 18 F-AV-1451, a radiotracer that binds to the pathological tau protein, may be helpful for in vivo visualization and quantitation of tau pathology in PSP. The objectives of this study were to investigate cortical and subcortical 18 F-AV-1451 binding patterns in patients with PSP. We recruited 14 PSP patients and compared their cortical and subcortical binding patterns in 18 F-AV-1451 positron emission tomography (PET) studies with those of 15 Parkinson's disease (PD) patients and 15 healthy controls. In both the PD and PSP groups, subcortical 18 F-AV-1451 binding did not correlate with the severity of motor dysfunctions, and cortical binding did not differ between the controls and each patient group. However, the PSP patients showed greater 18 F-AV-1451 binding in the putamen, globus pallidus, subthalamic nucleus, and dentate nucleus when compared with the controls, whereas the PD patients showed lower 18 F-AV-1451 binding in the substantia nigra than controls. The PSP and PD patients showed distinct subcortical 18 F-AV-1451 binding patterns reflecting subcortical tau pathology in PSP and reduced nigral neuromelanin in PD. However, there was no correlation with the severity of motor dysfunction, no cortical regions with increased binding in PSP patients, and variable degrees of subcortical binding even in the controls. Therefore, the 18 F-AV-1451 PET may be less than ideal for assessing tau pathology in PSP. Further studies will be required to validate the clinical correlation and to understand the clinical utility of 18 F-AV-1451 PET for PSP patients. © 2016 International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder Society.

  12. Validating novel tau PET tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

    Science.gov (United States)

    Marquie, Marta; Normandin, Marc D.; Vanderburg, Charles R.; Costantino, Isabel; Bien, Elizabeth A.; Rycyna, Lisa G.; Klunk, William E.; Mathis, Chester A.; Ikonomovic, Milos D.; Debnath, Manik L.; Vasdev, Neil; Dickerson, Bradford C.; Gomperts, Stephen N.; Growdon, John H.; Johnson, Keith A.; Frosch, Matthew P.; Hyman, Bradley T.; Gomez-Isla, Teresa

    2016-01-01

    Objective To examine region and substrate-specific autoradiographic and in vitro binding patterns of PET tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament tau-containing lesions, and to determine whether there is off-target binding to other amyloid/non-amyloid proteins. Methods We applied [F-18]-AV-1451 phosphor screen autoradiography, [F-18]-AV-1451 nuclear emulsion autoradiography and [H-3]-AV-1451 in vitro binding assays to the study of postmortem samples from patients with a definite pathological diagnosis of Alzheimer’s disease, frontotemporal lobar degeneration-tau, frontotemporal lobar degeneration-TDP-43, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, multiple system atrophy, cerebral amyloid angiopathy and elderly controls free of pathology. Results Our data suggest that AV-1451 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites, but does not seem to bind to a significant extent to neuronal and glial inclusions mainly composed of straight tau filaments in non-Alzheimer tauopathy brains or to β-amyloid, α-synuclein or TDP-43-containing lesions. AV-1451 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions was identified. Interpretation Our data suggest that AV-1451 holds promise as surrogate marker for the detection of brain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzheimer’s brains but also point to its relatively lower affinity for lesions primarily made of straight tau filaments in non-Alzheimer tauopathy cases and to the existence of some AV-1451 off-target binding. These findings provide important insights for interpreting in vivo patterns of [F-18]-AV-1451 retention. PMID:26344059

  13. [18F]AV-1451 tau-PET and primary progressive aphasia.

    Science.gov (United States)

    Josephs, Keith A; Martin, Peter R; Botha, Hugo; Schwarz, Christopher G; Duffy, Joseph R; Clark, Heather M; Machulda, Mary M; Graff-Radford, Jonathan; Weigand, Stephen D; Senjem, Matthew L; Utianski, Rene L; Drubach, Daniel A; Boeve, Bradley F; Jones, David T; Knopman, David S; Petersen, Ronald C; Jack, Clifford R; Lowe, Val J; Whitwell, Jennifer L

    2018-02-16

    To assess [ 18 F]AV-1451 tau-PET (positron emission tomography) uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic, and agrammatic), examine regional uptake patterns of [ 18 F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [ 18 F]AV-1451, [ 18 F]-fluorodeoxygluclose (FDG)-PET and MRI (magnetic resonance imaging) to differentiate the PPA variants. We performed statistical parametric mapping of [ 18 F]AV-1451 across 40 PPA patients (logopenic-PPA = 14, semantic-PPA = 13, and agrammatic-PPA = 13) compared to 80 cognitively normal, Pittsburgh compound B-negative controls, age and gender matched 2:1. Principal component analysis of regional [ 18 F]AV-1451 tau-PET standard uptake value ratio was performed to understand underlying patterns of [ 18 F]AV-1451 uptake independent of clinical diagnosis. Penalized multinomial regression analyses were utilized to assess diagnostic utility. Logopenic-PPA showed striking uptake throughout neocortex, particularly temporoparietal, compared to controls, semantic-PPA, and agrammatic-PPA. Semantic-PPA and agrammatic-PPA showed milder patterns of focal [ 18 F]AV-1451 uptake. Semantic-PPA showed elevated uptake (left>right) in anteromedial temporal lobes, compared to controls and agrammatic-PPA. Agrammatic-PPA showed elevated uptake (left>right) throughout prefrontal white matter and in subcortical gray matter structures, compared to controls and semantic-PPA. The principal component analysis of regional [ 18 F]AV-1451 indicated two primary dimensions, a severity dimension that distinguished logopenic-PPA from agrammatic-PPA and semantic-PPA, and a frontal versus temporal contrast that distinguishes agrammatic-PPA and semantic-PPA cases. Diagnostic utility of [ 18 F]AV-1451was superior to MRI and at least equal to FDG-PET. [ 18 F]AV-1451binding characteristics differ across the PPA variants and were excellent at distinguishing between the variants. [ 18

  14. Percepções e sentimentos de adolescentes criados por avós

    OpenAIRE

    Paixão, Flávia Juliana Dourado

    2013-01-01

    Este estudo tem como objetivo conhecer as percepções e os sentimentos de adolescentes criados por avós. Busca-se, especificamente: 1) descrever a percepção dos adolescentes sobre seus avós, seus sentimentos por eles e as relações estabelecidas com os mesmos; 2) descrever como percebem as figuras parentais biológicas, seus sentimentos por eles e suas relações com os mesmos; 3) compreender a experiência dos adolescentes acerca do fato de serem criados pelos avós; e 4) descrever a...

  15. Måleegenskaper ved den norske versjonen av Parental Stress Scales (PSS)

    OpenAIRE

    Kornør, Hege; Richter, Jörg

    2013-01-01

    - Beskrivelse. Parental Stress Scale (PSS) er et spørreskjema med 18 utsagn som foreldre skal besvare for å gi et mål på stressnivå forbundet med det å være foreldre. Instrumentet ble utgitt på engelsk av de amerikanske forskerne Judy O. Berry og Warren H. Jones i 1995. Ane Nærde ved Atferdssenteret står bak den norske oversettelsen. Opplysninger om rettighetshavere foreligger ikke. Tidsbruk og kompetansekrav knyttet til bruk av testen er ukjent. Litteratursøk. Av 51 identifiserte refe...

  16. Evaluering av Brobyggerprosjektet : arbeid overfor unge domfelte menn med somalisk og pakistansk bakgrunn

    OpenAIRE

    Gotaas, Nora; Højdahl, Torunn

    2006-01-01

    Brobyggerprosjektet ved Primærmedisinsk verksted var et 3- årig prosjekt rettet inn mot unge domfelte menn med somalisk og pakistansk bakgrunn. Formålet var å prøve ut virkemidler for å styrke den straffedømtes evne til mestring av egen livssituasjon, og å bygge og utvikle sosiale bånd mellom livet innenfor og livet utenfor fengselsmurene. Evalueringen beskriver og vurderer gjennomføringen av prosjektet. NIBRs del av rapporten er rettet inn mot de organisatoriske sidene v...

  17. [Total A-V block due to tuberous sclerosis. A case report].

    Science.gov (United States)

    Valente, N; Guidugli Neto, J; De Paola, A A; Pimenta, J

    1989-10-01

    Tuberous sclerosis is a neurologic disease affecting various organs with a triade: sebaceum adenoma, mental retardation and seizures. This report presents a case of a patient with tuberous sclerosis and third degree A-V block with complete invasive and non-invasive evaluation. The patient had sincope and complete A-V block with QRS complexes showing right bundle branch block morphology. The echocardiogram showed dilated cardiomyopathy with diffuse left ventricular dysfunction and had normal coronary arteriography. The eletrophysiologic evaluation showed complete infra-hisian A-V block and QRS with left bundle branch block pattern with normal sinus nodal and A-V nodal function. It was not possible to induce ventricular tachtyarrhythmias up to two extrastimuli. Histologic study showed normal myocardium under light and electronic microscopy. After permanent VVI pacemaker implant, the patient in follow-up for 16 years. This case seems to be the first in the international medical literature of tuberous sclerosis with complete heart block.

  18. Nätverksövervakning av trådlösa accesspunkter

    OpenAIRE

    Heino, Felix

    2016-01-01

    Syftet med examensarbetet är att analysera, implementera och utvärdera metoder för nätverksövervakning av trådlös kommunikationsutrustning i företaget Fibras nätverk. I dag sköts driften av cirka 2300 accesspunkter i Västerås stads trådlösa nätverk av Fibra. I nätverket ingår ett antal Wireless LAN Controller (WLC), vars uppgift är att hantera och konfigurera alla accesspunkter. Varje WLC kan hantera upp till 400 accesspunkter och sköter exempelvis autentiseringen av användarna. Dessutom finn...

  19. En utredning av meddelande-orienterade lager för Twingly

    OpenAIRE

    Säll, Robert

    2013-01-01

    Att flera datorer används för att gemensamt lösa problem är inte någonting nytt. Det finns många distribuerade system i bruk och många olika lösningar för hur dessa ska kommunicera med varandra. Vissa använder sig av meddelande-orienterade lager för kommunikation vilket det finns väldigt många implementationer av. RabbitMQ är ett exempel där att kommunikation går genom en (eller ett kluster av) central nod och kommunicerar med hjälp av protokollet Advanced Message Queue Protocol, AMQP. I en h...

  20. Inverkan av alkalisilikareaktion (ASR) på lamelldammars bärförmåga

    OpenAIRE

    Norberg, Sara; Sawasa, Hadeel

    2014-01-01

    Dammar är en viktig konstruktion i Sverige och i världen bland annat för vattenförsörjning, reglering av flöden och elproduktion. En expansion på grund av en alkalisilikareaktion (ASR) i en betongdamm kan leda till många problem. Bland annat kan det uppstå läckage av vatten och problem med öppning och stängning av luckor. Mycket forskning har lagts ner på att ta reda på hur ASR påverkar hållfastheten och bärförmågan hos betong. Detta examensarbete syftar till att genom en litteraturstudie vis...

  1. Neurofibromatosis with vertebral artery A-V fistula and cervical meningocele -a case report-

    International Nuclear Information System (INIS)

    Kim, Yong Joo; Suh, Kyung Jin; Kim, Tae Heon; Kang, Duk Sik; Park, Yeun Mook; Park, June Sik

    1988-01-01

    Arteriovenous fistula is a rare abnormality in patient with neurofibromatosis. A review of English-language literature revealed only 3 reported cases. We report a case of neurofibromatosis with vertebral artery A-V fistula and cervical meningocele

  2. Nettbrettet: Avisbransjens frelser? : En casestudie av nettbrettsatsingen til fire norske mediehus

    OpenAIRE

    Ihme, Henrik Albert

    2012-01-01

    Denne oppgavens formål er å sammenfatte satsingen på nettbrettutgaver i Norge, ved å studere mediehusene VG, Dagbladet, Aftenposten og Dagens Næringsliv. Oppgaven er utformet som en casestudie, og inneholder en kvantitativ undersøkelse av mediehusenes utgaver gjennom en uke, samt dybdeintervjuer med sentrale aktører. Satsingen sees i lys av utviklingen i avisbransjen de siste årene, samt teoretiske perspektiver som remediering og disruptiv innovering. Mediehusenes strategi og ulike forretning...

  3. Kvalitetsutvärdering av biomedicin och närliggande huvudområden

    DEFF Research Database (Denmark)

    Leffler, Hakon; Fex Svenningsen, Åsa; Emgård, Mia

    2014-01-01

    UKÄ:s utvärdering av biomedicinutbildningar visar på en mycket varierad kvalitet. Nio av 21 utbildningar håller toppklass medan mer än hälften bedöms vara bristande. 21 utbildningar inom biomedicin har satts under lupp. Kvaliteten bedöms som vanligt efter en tregradig skala: mycket hög kvalitet, ...

  4. [18F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP.

    Science.gov (United States)

    Coakeley, Sarah; Cho, Sang Soo; Koshimori, Yuko; Rusjan, Pablo; Ghadery, Christine; Kim, Jinhee; Lang, Anthony E; Houle, Sylvain; Strafella, Antonio P

    2018-03-01

    This study investigated binding of [ 18 F]AV-1451 to neuromelanin in the substantia nigra of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). [ 18 F]AV-1451 is a positron emission tomography radiotracer designed to bind pathological tau. A post-mortem study using [ 18 F]AV-1451 discovered off-target binding properties to neuromelanin in the substantia nigra. A subsequent clinical study reported a 30% decrease in [ 18 F]AV-1451 binding in the midbrain of PD patients. A total of 12 patients and 10 healthy age-matched controls were recruited. An anatomical MRI and a 90-min PET scan, using [ 18 F]AV-1451, were acquired from all participants. The standardized uptake value ratio (SUVR) from 60 to 90 min post-injection was calculated for the substantia nigra, using the cerebellar cortex as the reference region. The substantia nigra was delineated using automated region of interest software. An independent samples ANOVA and LSD post hoc testing were used to test for differences in [ 18 F]AV-1451 SUVR between groups. Substantia nigra SUVR from 60 to 90 min was significantly greater in HC compared to both PSP and PD groups. Although the PD group had the lowest SUVR, there was no significant difference in substantia nigra uptake between PD and PSP. [ 18 F]AV-1451 may be the first PET radiotracer capable of imaging neurodegeneration of the substantia nigra in parkinsonisms. Further testing must be done in PD and atypical parkinsonian disorders to support this off-target use of [ 18 F]AV-1451.

  5. Dynamics of AV coupling during human atrial fibrillation: role of atrial rate.

    Science.gov (United States)

    Masè, M; Marini, M; Disertori, M; Ravelli, F

    2015-07-01

    The causal relationship between atrial and ventricular activities during human atrial fibrillation (AF) is poorly understood. This study analyzed the effects of an increase in atrial rate on the link between atrial and ventricular activities during AF. Atrial and ventricular time series were determined in 14 patients during the spontaneous acceleration of the atrial rhythm at AF onset. The dynamic relationship between atrial and ventricular activities was quantified in terms of atrioventricular (AV) coupling by AV synchrogram analysis. The technique identified n:m coupling patterns (n atrial beats in m ventricular cycles), quantifying their percentage, maximal length, and conduction ratio (= m/n). Simulations with a difference-equation AV model were performed to correlate the observed dynamics to specific atrial/nodal properties. The atrial rate increase significantly affected AV coupling and ventricular response during AF. The shortening of atrial intervals from 185 ± 32 to 165 ± 24 ms (P AV patterns with progressively decreasing m/n ratios (from conduction ratio = 0.34 ± 0.09 to 0.29 ± 0.08, P AV block and coupling instability at higher atrial rates were associated with increased ventricular interval variability (from 123 ± 52 to 133 ± 55 ms, P AV pattern transitions and coupling instability in patients were predicted, assuming the filtering of high-rate irregular atrial beats by the slow recovery of nodal excitability. These results support the role of atrial rate in determining AV coupling and ventricular response and may have implications for rate control in AF. Copyright © 2015 the American Physiological Society.

  6. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging.

    Science.gov (United States)

    Marquié, Marta; Siao Tick Chong, Michael; Antón-Fernández, Alejandro; Verwer, Eline E; Sáez-Calveras, Nil; Meltzer, Avery C; Ramanan, Prianca; Amaral, Ana C; Gonzalez, Jose; Normandin, Marc D; Frosch, Matthew P; Gómez-Isla, Teresa

    2017-10-01

    [F-18]-AV-1451, a PET tracer specifically developed to detect brain neurofibrillary tau pathology, has the potential to facilitate accurate diagnosis of Alzheimer's disease (AD), staging of brain tau burden and monitoring disease progression. Recent PET studies show that patients with mild cognitive impairment and AD dementia exhibit significantly higher in vivo [F-18]-AV-1451 retention than cognitively normal controls. Importantly, PET patterns of [F-18]-AV-1451 correlate well with disease severity and seem to match the predicted topographic Braak staging of neurofibrillary tangles (NFTs) in AD, although this awaits confirmation. We studied the correlation of autoradiographic binding patterns of [F-18]-AV-1451 and the stereotypical spatiotemporal pattern of progression of NFTs using legacy postmortem brain samples representing different Braak NFT stages (I-VI). We performed [F-18]-AV-1451 phosphor-screen autoradiography and quantitative tau measurements (stereologically based NFT counts and biochemical analysis of tau pathology) in three brain regions (entorhinal cortex, superior temporal sulcus and visual cortex) in a total of 22 cases: low Braak (I-II, n = 6), intermediate Braak (III-IV, n = 7) and high Braak (V-VI, n = 9). Strong and selective [F-18]-AV-1451 binding was detected in all tangle-containing regions matching precisely the observed pattern of PHF-tau immunostaining across the different Braak stages. As expected, no signal was detected in the white matter or other non-tangle containing regions. Quantification of [F-18]-AV-1451 binding was very significantly correlated with the number of NFTs present in each brain region and with the total tau and phospho-tau content as reported by Western blot and ELISA. [F-18]-AV-1451 is a promising biomarker for in vivo quantification of brain tau burden in AD. Neuroimaging-pathologic studies conducted on postmortem material from individuals imaged while alive are now needed to confirm these observations.

  7. Utilization of Electrocardiographic P-wave Duration for AV Interval Optimization in Dual-Chamber Pacemakers.

    Science.gov (United States)

    Sorajja, Dan; Bhakta, Mayurkumar D; Scott, Luis Rp; Altemose, Gregory T; Srivathsan, Komandoor

    2010-09-05

    Empiric programming of the atrio-ventricular (AV) delay is commonly performed during pacemaker implantation. Transmitral flow assessment by Doppler echocardiography can be used to find the optimal AV delay by Ritter's method, but this cannot easily be performed during pacemaker implantation. We sought to determine a non-invasive surrogate for this assessment. Since electrocardiographic P-wave duration estimates atrial activation time, we hypothesized this measurement may provide a more appropriate basis for programming AV intervals. A total of 19 patients were examined at the time of dual chamber pacemaker implantation, 13 (68%) being male with a mean age of 77. Each patient had the optimal AV interval determined by Ritter's method. The P-wave duration was measured independently on electrocardiograms using MUSE® Cardiology Information System (version 7.1.1). The relationship between P-wave duration and the optimal AV interval was analyzed. The P-wave duration and optimal AV delay were related by a correlation coefficient of 0.815 and a correction factor of 1.26. The mean BMI was 27. The presence of hypertension, atrial fibrillation, and valvular heart disease was 13 (68%), 3 (16%), and 2 (11%) respectively. Mean echocardiographic parameters included an ejection fraction of 58%, left atrial index of 32 ml/m(2), and diastolic dysfunction grade 1 (out of 4). In patients with dual chamber pacemakers in AV sequentially paced mode and normal EF, electrocardiographic P-wave duration correlates to the optimal AV delay by Ritter's method by a factor of 1.26.

  8. Et sosiologisk blikk på mobbing. En teoretisk studie av paradigmet og fenomenet mobbing

    OpenAIRE

    Stemland, Linn

    2007-01-01

    Mobbing er et tema som har fått stadig mer oppmerksomhet i samfunnsdebatten. Det er gjort lite sosiologisk forskning omkring fenomenet mobbing. Forskningsfeltet mobbing er i dag konstruert og dominert av psykologiens begreper og forståelse. I denne oppgaven prøver jeg å nærme meg en sosiologisk forståelse av begrepet og fenomenet mobbing.

  9. Adaptationer av Esaias Tegnérs Frithiofs saga

    DEFF Research Database (Denmark)

    Nordenfors, Ola

    2008-01-01

    Tegnérs versepos över urnordiska myter hade länge ett starkt om den nordiska läsande allmänheten - därtill starkt understött av Bernhard Crusells omtyckta tonsättningar av dikterna. Men också i Tyskland har Frithiofs saga haft en påfallande genomslagskraft. I uppsatsen granskas särskilt tonsättar...

  10. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).

    Science.gov (United States)

    Hutchinson, Mark R; Lewis, Susannah S; Coats, Benjamen D; Skyba, David A; Crysdale, Nicole Y; Berkelhammer, Debra L; Brzeski, Anita; Northcutt, Alexis; Vietz, Christine M; Judd, Charles M; Maier, Steven F; Watkins, Linda R; Johnson, Kirk W

    2009-02-01

    Morphine-induced glial proinflammatory responses have been documented to contribute to tolerance to opioid analgesia. Here, we examined whether drugs previously shown to suppress glial proinflammatory responses can alter other clinically relevant opioid effects; namely, withdrawal or acute analgesia. AV411 (ibudilast) and minocycline, drugs with distinct mechanisms of action that result in attenuation of glial proinflammatory responses, each reduced naloxone-precipitated withdrawal. Analysis of brain nuclei associated with opioid withdrawal revealed that morphine altered expression of glial activation markers, cytokines, chemokines, and a neurotrophic factor. AV411 attenuated many of these morphine-induced effects. AV411 also protected against spontaneous withdrawal-induced hyperactivity and weight loss recorded across a 12-day timecourse. Notably, in the spontaneous withdrawal study, AV411 treatment was delayed relative to the start of the morphine regimen so to also test whether AV411 could still be effective in the face of established morphine dependence, which it was. AV411 did not simply attenuate all opioid effects, as co-administering AV411 with morphine or oxycodone caused three-to-five-fold increases in acute analgesic potency, as revealed by leftward shifts in the analgesic dose response curves. Timecourse analyses revealed that plasma morphine levels were not altered by AV411, suggestive that potentiated analgesia was not simply due to prolongation of morphine exposure or increased plasma concentrations. These data support and extend similar potentiation of acute opioid analgesia by minocycline, again providing converging lines of evidence of glial involvement. Hence, suppression of glial proinflammatory responses can significantly reduce opioid withdrawal, while improving analgesia.

  11. Helhetsorienterad utvärdering av kollektivtrafikåtgärder

    DEFF Research Database (Denmark)

    Hiselius, Lena Winslott; Barfod, Michael Bruhn; Leleur, Steen

    Under hösten 2008 och våren 2009 har forskare vid Avd. Trafik och väg vid Lunds Tekniska Högskola, DTU Transport vid Danmarks Tekniska Universitet samt National-ekonomiska institutionen vid Lunds Universitet genomfört ett forskningsprojekt med syfte att studera tillämpningen av en sammansatt...... (helhetsorienterad) analys av kollektiv-trafikåtgärder....

  12. Simplified Cardioneuroablation in the Treatment of Reflex Syncope, Functional AV Block, and Sinus Node Dysfunction.

    Science.gov (United States)

    Aksu, Tolga; Golcuk, Ebru; Yalin, Kivanç; Guler, Tümer Erdem; Erden, Ismail

    2016-01-01

    Cardio neuroablation (CNA) is a lesser-known technique for management of patients with excessive vagal activation on the basis of radiofrequency catheter ablation (RFCA) of the areas related to the three main autonomic ganglia around the heart. We investigated the effectiveness of selective and/or stepwise RFCA of these areas via right atrium (RA) and/or left atrium (LA) in the patients with recurrent syncope due to excessive vagal activity. Twenty-two patients presenting symptomatic functional bradyarrhythmias, neurally mediated reflex syncope (NMS), symptomatic atrioventricular (AV) block, and symptomatic sinus node dysfunction (SND; number = 8, 7, 7, respectively) were enrolled. The three main paracardiac ganglia were targeted via RA and LA in the patients with NMS and SND. The procedure was performed via RA in the patients with AV block, followed by RFCA of all ganglia via LA, if AV conduction disorder persists. The sites showing fragmented potentials were identified by electrical mapping and verified by high-frequency stimulation and ablated until atrial electrical potential was completely eliminated (AV block. Despite the increased heart rate, the resolution of AV block after the RFCA could not be achieved in one patient who had partial resolution with atropine infusion on admission. CNA may be an alternative and safe strategy to reduce NMS episodes, and to treat functional AV block and symptomatic SND, especially in young patients. © 2015 Wiley Periodicals, Inc.

  13. BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration.

    Science.gov (United States)

    Inai, Kei; Burnside, Jessica L; Hoffman, Stanley; Toole, Bryan P; Sugi, Yukiko

    2013-01-01

    Distal outgrowth and maturation of mesenchymalized endocardial cushions are critical morphogenetic events during post-EMT atrioventricular (AV) valvuloseptal morphogenesis. We explored the role of BMP-2 in the regulation of valvulogenic extracellular matrix (ECM) components, versican and hyaluronan (HA), and cell migration during post-EMT AV cushion distal outgrowth/expansion. We observed intense staining of versican and HA in AV cushion mesenchyme from the early cushion expansion stage, Hamburger and Hamilton (HH) stage-17 to the cushion maturation stage, HH stage-29 in the chick. Based on this expression pattern we examined the role of BMP-2 in regulating versican and HA using 3D AV cushion mesenchymal cell (CMC) aggregate cultures on hydrated collagen gels. BMP-2 induced versican expression and HA deposition as well as mRNA expression of versican and Has2 by CMCs in a dose dependent manner. Noggin, an antagonist of BMP, abolished BMP-2-induced versican and HA as well as mRNA expression of versican and Has2. We further examined whether BMP-2-promoted cell migration was associated with expression of versican and HA. BMP-2- promoted cell migration was significantly impaired by treatments with versican siRNA and HA oligomer. In conclusion, we provide evidence that BMP-2 induces expression of versican and HA by AV CMCs and that these ECM components contribute to BMP-2-induced CMC migration, indicating critical roles for BMP-2 in distal outgrowth/expansion of mesenchymalized AV cushions.

  14. BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration.

    Directory of Open Access Journals (Sweden)

    Kei Inai

    Full Text Available Distal outgrowth and maturation of mesenchymalized endocardial cushions are critical morphogenetic events during post-EMT atrioventricular (AV valvuloseptal morphogenesis. We explored the role of BMP-2 in the regulation of valvulogenic extracellular matrix (ECM components, versican and hyaluronan (HA, and cell migration during post-EMT AV cushion distal outgrowth/expansion. We observed intense staining of versican and HA in AV cushion mesenchyme from the early cushion expansion stage, Hamburger and Hamilton (HH stage-17 to the cushion maturation stage, HH stage-29 in the chick. Based on this expression pattern we examined the role of BMP-2 in regulating versican and HA using 3D AV cushion mesenchymal cell (CMC aggregate cultures on hydrated collagen gels. BMP-2 induced versican expression and HA deposition as well as mRNA expression of versican and Has2 by CMCs in a dose dependent manner. Noggin, an antagonist of BMP, abolished BMP-2-induced versican and HA as well as mRNA expression of versican and Has2. We further examined whether BMP-2-promoted cell migration was associated with expression of versican and HA. BMP-2- promoted cell migration was significantly impaired by treatments with versican siRNA and HA oligomer. In conclusion, we provide evidence that BMP-2 induces expression of versican and HA by AV CMCs and that these ECM components contribute to BMP-2-induced CMC migration, indicating critical roles for BMP-2 in distal outgrowth/expansion of mesenchymalized AV cushions.

  15. Whether noninvasive optimization of AV and VV delays improves the response to cardiac resynchronization therapy.

    Science.gov (United States)

    Urbanek, Bożena; Chudzik, Michał; Klimczak, Artur; Rosiak, Marcin; Lewek, Joanna; Wranicz, Jerzy Krzysztof

    2013-01-01

    Device optimization is not routinely performed in patients who underwent cardiac resynchronization therapy (CRT) device implantation. Noninvasive optimization of CRT devices by measurement of cardiac output (CO) can be used as a simple method to assess ventricular systolic performance. The aim of this study was to assess whether optimization of atrioventricular (AV) and interventricular (VV) delay can improve hemodynamic response to CRT and whether this optimization should be performed for each patient individually. Twenty patients with advanced heart failure New York Heart Association (NYHA) class III/IV, left ventricular ejection fraction ≤ 35% and left bundle branch block (QRS ≥ 120 ms) in sinus rhythm were evaluated from 24 h to 48 h after implantation of a CRT device by means of impedance cardiography (ICG). CO was first measured at each patient's intrinsic rhythm. Patients then underwent adjustments of AV and VV delay from 80 ms to 140 ms and from -60 ms to +60 ms, respectively in 20 ms increment steps and CO at each setting was measured by ICG. Both AV and VV delays were programmed according to the greatest improvement in CO compared to intrinsic rhythm. There was a statistically signifi cant increase in CO measured at the intrinsic rhythm compared to different AV delay by mean of 21% (3.8 ± 1.0 vs. 4.6 ± 0.1 L/min, p AV/VV delays with left ventricle-preexcitation or simultaneous biventricular pacing caused additional increased CO from intrinsic rhythm by mean of 32.6% (3.8 ± 1.0 vs. 5.04 ± ± 1.0 L/min, p AV/VV setting delays also resulted in improved hemodynamic responses compared to VV factory setting delay. Both AV and VV delay optimization should be performed in clinical practice. Optimal AV delay improved outcome. However, combination of optimized AV/VV delays provided the best hemodynamic response. Optimized AV/VV delays with left ventricle-preexcitation or simultaneous biventricular pacing increased hemodynamic output compared to intrinsic

  16. Güneydoğu Marmara'da Algarna ile Karides Avcılığında Av Kompozisyonu ve Hedef Dışı Av.

    Directory of Open Access Journals (Sweden)

    Yusuf Kenan Bayhan

    2015-12-01

    Full Text Available Bir yıl süre ile yürütülen bu çalışma, Kasım 2000 - Ekim 2001 tarihleri arasında Güneydoğu Marmara’da gerçekleştirilmiştir. Çalışmada, algarna ile avcılıkta hedef tür olan derin su pembe karidesi (Parapenaeus longirostris’in ağırlık ve sayısal miktarları ile bunun dışındaki av kompozisyonu, türlerin boy dağılımları ve toplam av içerisindeki sayısal oranları araştırılmıştır. Yapılan çekimler sonucunda, toplam avın sayısal olarak % 64.5’ni hedef tür olan Parapenaeus longirostris, % 35.5’ini hedef dışı av oluşturmuştur. 50 türün bulunduğu hedef dışı avın % 17.16’sını Kemikli balıklar (Osteichthyes, % 8.58’ini Kabuklular (Crustacea-Decapoda, % 4.94’ünü Derisi Dikenliler (Echinodermata, % 2.53’ünü Yumuşakçalar (Mollusca, % 2.14’ünü Cnidaria ve % 0.13’ünü kıkırdaklı balıklar (Chondrichthyes oluşturmuş, toplam av içerisinde Parapenaeus longirostris’in dışında sayısal olarak en çok yakalanan türlerin başında ise Kaya balığı, Mezgit, Kancaağız pisi, Yengeç, Deniz yıldızı ve Deniz hıyarı’nın geldiği belirlenmiştir

  17. A 2:1 AV rhythm: an adverse effect of a long AV delay during DDI pacing and its prevention by the ventricular intrinsic preference algorithm in DDD mode.

    Science.gov (United States)

    Minamiguchi, Hitoshi; Oginosawa, Yasushi; Kohno, Ritsuko; Tamura, Masahito; Takeuchi, Masaaki; Otsuji, Yutaka; Abe, Haruhiko

    2012-07-01

    A 91-year-old woman received a dual-chamber pacemaker for sick sinus syndrome and intermittently abnormal atrioventricular (AV) conduction. The pacemaker was set in DDI mode with a 350-ms AV delay to preserve intrinsic ventricular activity. She complained of palpitation during AV sequential pacing. The electrocardiogram showed a 2:1 AV rhythm from 1:1 ventriculoatrial (VA) conduction during ventricular pacing in DDI mode with a long AV interval. After reprogramming of the pacemaker in DDD mode with a 250-ms AV interval and additional 100-ms prolongation of the AV interval by the ventricular intrinsic preference function, VA conduction disappeared and the patient's symptom were alleviated without increasing unnecessary right ventricular pacing. ©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc.

  18. Integrated rate-dependent and dual pathway AV nodal functions: principles and assessment framework.

    Science.gov (United States)

    Billette, Jacques; Tadros, Rafik

    2014-01-15

    The atrioventricular (AV) node conducts slowly and has a long refractory period. These features sustain the filtering of atrial impulses and hence are often modulated to optimize ventricular rate during supraventricular tachyarrhythmias. The AV node is also the site of a clinically common reentrant arrhythmia. Its function is assessed for a variety of purposes from its responses to a premature protocol (S1S2, test beats introduced at different cycle lengths) repeatedly performed at different basic rates and/or to an incremental pacing protocol (increasingly faster rates). Puzzlingly, resulting data and interpretation differ with protocols as well as with chosen recovery and refractory indexes, and are further complicated by the presence of built-in fast and slow pathways. This problem applies to endocavitary investigations of arrhythmias as well as to many experimental functional studies. This review supports an integrated framework of rate-dependent and dual pathway AV nodal function that can account for these puzzling characteristics. The framework was established from AV nodal responses to S1S2S3 protocols that, compared with standard S1S2 protocols, allow for an orderly quantitative dissociation of the different factors involved in changes in AV nodal conduction and refractory indexes under rate-dependent and dual pathway function. Although largely based on data from experimental studies, the proposed framework may well apply to the human AV node. In conclusion, the rate-dependent and dual pathway properties of the AV node can be integrated within a common functional framework the contribution of which to individual responses can be quantitatively determined with properly designed protocols and analytic tools.

  19. A Practical ECG Criterion to Unmask Left Accessory AV Connections in Patients With Subtle Preexcitation.

    Science.gov (United States)

    Thompson, J Jenkins; Shah, Jignesh; Charnigo, Richard; Tackett, Andrea; Darrat, Yousef H; Bailey, Alison; Delisle, Brian; Kakavand, Bahram; DI Biase, Luigi; Natale, Andrea; Morales, Gustavo; Elayi, Claude S

    2015-05-20

    Accessory AV-connections capable of antegrade conduction need to be recognized because of the potential for life-threatening arrhythmias. However, the preexcited ECG pattern may be subtle, especially among left-sided AV-connections. We explored whether additional ECG criteria might help identify left-sided AV-connections. We analyzed 156 patients who underwent an electrophysiology study (EPS) and ablation for paroxysmal supraventricular tachycardias (PSVT). Patients were divided into 2 groups: those with left-sided AV-connections (Group 1) and all other PSVT (Group 2). Various ECG parameters were compared before and after ablation in both groups. The EPS identified left-sided AV-connections among 43 patients (Group 1) and excluded it among 113 (Group 2). Baseline ECG in Group 1 demonstrated obvious preexcitation among 24/43 patients (55.8%), the remaining 19/43 missing obvious preexcitation. R/S ratio > 0.5 in V1 was noted in 38/43 (88.4%) patients in Group 1 before ablation (median 1.00; IQR 0.58-2.20), including 16/19 (84.2%) patients lacking obvious left-sided AVconnections. Conversely, only 10/113 (8.8%) patients in Group 2 had R/S ratios in V1 ≥ 0.5 (0.20; 0.10-0.31), P AV-connections (sensitivity 93.0%). The negative predictive value of this combined criterion was 103/106 (97.2%). In symptomatic patients, combining the R/S ratio (≥ 0.5) in lead V1 with the classic preexcitation pattern on ECG markedly improved the sensitivity to diagnose left-sided AV-connections. This ratio may be particularly useful among patients lacking obvious preexcitation. © 2015 Wiley Periodicals, Inc.

  20. A novel curve fitting method for AV optimisation of biventricular pacemakers.

    Science.gov (United States)

    Dehbi, Hakim-Moulay; Jones, Siana; Sohaib, S M Afzal; Finegold, Judith A; Siggers, Jennifer H; Stegemann, Berthold; Whinnett, Zachary I; Francis, Darrel P

    2015-09-01

    In this study, we designed and tested a new algorithm, which we call the 'restricted parabola', to identify the optimum atrioventricular (AV) delay in patients with biventricular pacemakers. This algorithm automatically restricts the hemodynamic data used for curve fitting to the parabolic zone in order to avoid inadvertently selecting an AV optimum that is too long.We used R, a programming language and software environment for statistical computing, to create an algorithm which applies multiple different cut-offs to partition curve fitting of a dataset into a parabolic and a plateau region and then selects the best cut-off using a least squares method. In 82 patients, AV delay was adjusted and beat-to-beat systolic blood pressure (SBP) was measured non-invasively using our multiple-repetition protocol. The novel algorithm was compared to fitting a parabola across the whole dataset to identify how many patients had a plateau region, and whether a higher hemodynamic response was achieved with one method.In 9/82 patients, the restricted parabola algorithm detected that the pattern was not parabolic at longer AV delays. For these patients, the optimal AV delay predicted by the restricted parabola algorithm increased SBP by 1.36 mmHg above that predicted by the conventional parabolic algorithm (95% confidence interval: 0.65 to 2.07 mmHg, p-value = 0.002).AV optima selected using our novel restricted parabola algorithm give a greater improvement in acute hemodynamics than fitting a parabola across all tested AV delays. Such an algorithm may assist the development of automated methods for biventricular pacemaker optimisation.

  1. Nye estimater av organdoser til barn ved datatomografi (CT) utført på 1990-tallet i Norge

    OpenAIRE

    Toft, Benthe

    2013-01-01

    Masteroppgave i Folkehelsevitenskap ved Institutt for plante- og miljøvitenskap. 30 studiepoeng. Bakgrunn: Bruk av datatomografi (CT) har økt i Norge de siste ti årene og står nå for 80 % av befolkningsdosen fra medisinsk bruk av stråling. Det er usikkerhet rundt risikoen ved bruk av ioniserende stråling, særlig knyttet til CT av barn og unge. En stor internasjonal studie (EPI-CT-prosjektet) tar sikte på å skaffe økt kunnskap om risiko for leukemi og hjernekreft forbundet med CT-undersøkel...

  2. AV interval optimization using pressure volume loops in dual chamber pacemaker patients with maintained systolic left ventricular function.

    Science.gov (United States)

    Eberhardt, Frank; Hanke, Thorsten; Fitschen, Joern; Heringlake, Matthias; Bode, Frank; Schunkert, Heribert; Wiegand, Uwe K H

    2012-08-01

    Atrioventricular (AV) interval optimization is often deemed too time-consuming in dual-chamber pacemaker patients with maintained LV function. Thus the majority of patients are left at their default AV interval. To quantify the magnitude of hemodynamic improvement following AV interval optimization in chronically paced dual chamber pacemaker patients. A pressure volume catheter was placed in the left ventricle of 19 patients with chronic dual chamber pacing and an ejection fraction >45 % undergoing elective coronary angiography. AV interval was varied in 10 ms steps from 80 to 300 ms, and pressure volume loops were recorded during breath hold. The average optimal AV interval was 152 ± 39 ms compared to 155 ± 8 ms for the average default AV interval (range 100-240 ms). The average improvement in stroke work following AV interval optimization was 935 ± 760 mmHg/ml (range 0-2,908; p AV interval changes the average stroke work by 207 ± 162 mmHg/ml. AV interval optimization also leads to improved systolic dyssynchrony indices (17.7 ± 7.0 vs. 19.4 ± 7.1 %; p = 0.01). The overall hemodynamic effect of AV interval optimization in patients with maintained LV function is in the same range as for patients undergoing cardiac resynchronization therapy for several parameters. The positive effect of AV interval optimization also applies to patients who have been chronically paced for years.

  3. Den blivande förskollärarens formering. En studie av verksamhetsförlagda handledningssamtal, argumentationstraditioner och metaforik

    Directory of Open Access Journals (Sweden)

    Marie-Louise Hjort

    2014-06-01

    Full Text Available I denna studie analyserar vi hur erfarna förskollärare i rollen som handledare introducerar förskollärarstudenter i professionen. Studien genomförs mot bakgrund av ett delvis nytt uppdrag som förskolan fått under senare år, som bland annat yttrar sig i att förskolan nu är en del av utbildningssystemet. Med utgångspunkt i det teoretiska begreppet argumentationstraditioner och genom att analysera metaforiken i deltagarnas resonerande, studeras hur erfarna och blivande förskollärare navigerar spänningar centrala för professionen. Deltagarnas betoning av vissa argumentationstraditioner och användningen av viss metaforik diskuteras i termer av vad de implicerar för utvecklingen av de barn som deltar i en förskoleverksamhet som formas av dessa.

  4. 18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy.

    Science.gov (United States)

    Passamonti, Luca; Vázquez Rodríguez, Patricia; Hong, Young T; Allinson, Kieren S J; Williamson, David; Borchert, Robin J; Sami, Saber; Cope, Thomas E; Bevan-Jones, W Richard; Jones, P Simon; Arnold, Robert; Surendranathan, Ajenthan; Mak, Elijah; Su, Li; Fryer, Tim D; Aigbirhio, Franklin I; O'Brien, John T; Rowe, James B

    2017-03-01

    The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies. New radioligands for positron emission tomography have generated considerable interest, and controversy, in their potential as tau biomarkers. We assessed the radiotracer 18F-AV-1451 with positron emission tomography imaging to compare the distribution and intensity of tau pathology in 15 patients with Alzheimer's pathology (including amyloid-positive mild cognitive impairment), 19 patients with progressive supranuclear palsy, and 13 age- and sex-matched controls. Regional analysis of variance and a support vector machine were used to compare and discriminate the clinical groups, respectively. We also examined the 18F-AV-1451 autoradiographic binding in post-mortem tissue from patients with Alzheimer's disease, progressive supranuclear palsy, and a control case to assess the 18F-AV-1451 binding specificity to Alzheimer's and non-Alzheimer's tau pathology. There was increased 18F-AV-1451 binding in multiple regions in living patients with Alzheimer's disease and progressive supranuclear palsy relative to controls [main effect of group, F(2,41) = 17.5, P AV-1451 binding was significantly increased in patients with Alzheimer's disease, relative to patients with progressive supranuclear palsy and with control subjects, in the hippocampus and in occipital, parietal, temporal, and frontal cortices (t's > 2.2, P's AV-1451 binding was elevated in the midbrain (t = 2.1, P AV-1451 uptake in the putamen, pallidum, thalamus, midbrain, and in the dentate nucleus of the cerebellum (t's > 2.7, P's AV-1451 strongly bound to Alzheimer-related tau pathology, but less specifically in progressive supranuclear palsy. 18F-AV-1451 binding to the basal ganglia was strong in all groups in vivo. Postmortem histochemical staining showed absence of

  5. Kjøring med mistanke om påvirkning av andre rusmidler enn alkohol

    Directory of Open Access Journals (Sweden)

    Asbjørg S. Christophersen

    2009-10-01

    Full Text Available  SAMMENDRAGStatens rettstoksikologiske institutt har i løpet av de siste år registrert en stor økning av prøver fra bilføreremistenkt for kjøring under påvirkning av andre rusmidler enn alkohol. Antall positive saker økte 42% fra1994 til 1995. De hyppigste påviste stoffer er tetrahydrocannabinol, amfetamin, benzodiazepiner og opiater(morfin/kodein. Bruk av tyngre narkotiske stoffer har blitt mer vanlig i trafikksammenheng og antall positivetilfeller har økt betydelig mer enn totalt antall saker. Fra 1994 til 1995 økte antall positive amfetaminprøvermed 75% (fra 533 til 937 og antall positive prøver som følge av heroininntak økte med 87% (fra 92 til 172.Bruk av flere stoffer samtidig er vanlig, over 60 % av sakene i 1995 var positive på mer enn ett stoff, alkoholikke medregnet. De fleste tilfeller var representert av menn i alderen 25-32 år (37%. Kvinner var representerti ca. 11% av sakene.Christophersen AS, Skurtveit S, Mørland J. Drivers suspected to drive under the influence of drugs otherthan alcohol. Nor J Epidemiol 1996; 6 (1: 45-48.ENGLISH SUMMARYThe National Institute of Forensic Toxicology has registered a large increase in the number of samples fromdrivers suspected to drive under influence of drugs other than alcohol. The number of drug positive casesincreased 42% from 1994 to 1995. The most frequent drugs detected are tetrahydrocannabinol, amphetamine,benzodiazepines and opiates (morphine/codeine. The frequency of hard narcotic drug use has increased morethan the total number of cases. From 1994 to 1995, the number of amphetamine positive samples increased75% (from 533 to 937 and the number of samples positive due to heroin use (detection of the metabolite 6-monoacetylmorphine in urine increased 87%. Multi-drug use is common and more than one drug wasdetected in more than 60% of the cases from 1995, alcohol not included. Most of the cases were representedby men 25-32 years old (37%. Women were represented in about

  6. sugE: A gene involved in tributyltin (TBT) resistance of Aeromonas molluscorum Av27.

    Science.gov (United States)

    Cruz, Andreia; Micaelo, Nuno; Félix, Vitor; Song, Jun-Young; Kitamura, Shin-Ichi; Suzuki, Satoru; Mendo, Sónia

    2013-01-01

    The mechanism of bacterial resistance to tributyltin (TBT) is still unclear. The results herein presented contribute to clarify that mechanism in the TBT-resistant bacterium Aeromonas molluscorum Av27. We have identified and cloned a new gene that is involved in TBT resistance in this strain. The gene is highly homologous (84%) to the Aeromonas hydrophila-sugE gene belonging to the small multidrug resistance gene family (SMR), which includes genes involved in the transport of lipophilic drugs. In Av27, expression of the Av27-sugE was observed at the early logarithmic growth phase in the presence of a high TBT concentration (500 μM), thus suggesting the contribution of this gene for TBT resistance. E. coli cells transformed with Av27-sugE become resistant to ethidium bromide (EtBr), chloramphenicol (CP) and tetracycline (TE), besides TBT. According to the Moriguchi logP (miLogP) values, EtBr, CP and TE have similar properties and are substrates for the sugE-efflux system. Despite the different miLogP of TBT, E. coli cells transformed with Av27-sugE become resistant to this compound. So it seems that TBT is also a substrate for the SugE protein. The modelling studies performed also support this hypothesis. The data herein presented clearly indicate that sugE is involved in TBT resistance of this bacterium.

  7. Context-Aware UPnP-AV Services for Adaptive Home Multimedia Systems

    Directory of Open Access Journals (Sweden)

    Roland Tusch

    2008-01-01

    Full Text Available One possibility to provide mobile multimedia in domestic multimedia systems is the use of Universal Plug and Play Audio Visual (UPnP-AV devices. In a standard UPnP-AV scenario, multimedia content provided by a Media Server device is streamed to Media Renderer devices by the initiation of a Control Point. However, there is no provisioning of context-aware multimedia content customization. This paper presents an enhancement of standard UPnP-AV services for home multimedia environments regarding context awareness. It comes up with context profile definitions, shows how this context information can be queried from the Media Renderers, and illustrates how a Control Point can use this information to tailor a media stream from the Media Server to one or more Media Renderers. Moreover, since a standard Control Point implementation only queries one Media Server at a time, there is no global view on the content of all Media Servers in the UPnP-AV network. This paper also presents an approach of multimedia content integration on the Media Server side that provides fast search for content on the network. Finally, a number of performance measurements show the overhead costs of our enhancements to UPnP-AV in order to achieve the benefits.

  8. Handelsbankens användande av CRM -Är det lönsamt?

    OpenAIRE

    Salman Kanbar, Ahmad

    2012-01-01

    Frågeställning: På vilket sätt används CRM av Handelsbanken och hur påverkar det bankens lönsamhet? Syfte: Syftet med detta arbete är att kunna öka kunskapen om hur Handelsbanken tillämpar CRM och för att undersöka om användandet av CRM i bankens verksamhet är lönsamt eller inte. Metod: För att svara på studiens syfte blev en intervju utförd med Handelsbanken. Ännu en anledning till varför en intervju gjordes var på grund av att det var nödvändigt för att få det primärdata som behövdes och fö...

  9. Miljöanalys av arbetsmoment i vägprojekt

    OpenAIRE

    Sahlin, Jonathan; Jakobsson, Mattias

    2017-01-01

    Klimatpåverkan och energiförbrukning är ett av de stora miljöproblemen runt om i världen idag. Sedan den industriella revolutionens start har mängden utsläpp av bland annat koldioxid ökat exponentiellt med årens lopp och skapat obalans i klimatet, inte minst på grund av restprodukter och skadliga ämnen som används inom bland annat byggindustrin. Syftet med denna studie är att ta reda på vilka arbetsmoment som har störst påverkan på miljön för att sedan, om möjligt, ta fram förslag på hur det ...

  10. FastVDO enhancements of the AV1 codec and comparison to HEVC and JVET codecs

    Science.gov (United States)

    Topiwala, Pankaj; Dai, Wei; Krishnan, Madhu

    2017-09-01

    This paper describes a study to investigate possible ways to improve the AV1 codec, in several directions, most particularly in the context of 10-bit HDR video content, and 8/10 bit image content. Applications to SDR video, and 360 content are discussed elsewhere. For HDR content, a data adaptive grading technique in conjunction with the AV1 codec is studied. For image content, lapped biorthogonal transforms for (near) lossless compression is studied. For scalability-type applications, we introduce advanced resampling filters which outperform current ones. It is asserted that useful improvements are possible in each of these categories. In particular, substantial value is offered in the coding of HDR content, very competitive with HEVC HDR10, in a coding framework offering backwards compatibility with SDR. We also provide a rudimentary comparison of AV1 to the standard HEVC as well as the developing JVET codecs.

  11. Forholdet mellom stat og kommune i styring av norsk utdanningspolitikk 1970 - 2008

    Directory of Open Access Journals (Sweden)

    Øystein Engeland

    2009-06-01

    Full Text Available Denne artikkelen er skrevet ut fra en antakelse om at norsk utdanningsforvaltning etter 1990 illustrerer forsøk på å styrke den statlige forvaltning innen et desentralisert system. Ikke minst er dette tydelig ved at nasjonal styring av utdanning særlig etter århundreskiftet har økt på bekostning av det lokale selvstyret. I forhold til maktfordelingen mellom staten og kommunene er vi nå nærmest tilbake til situasjonen før den politiske desentraliseringsbølgen startet mot slutten av 1970-tallet. Det nasjonale nivået er i ferd med å etablere et styringsgrep på skolesiden som er så omfattende at det mangler sidestykke i moderne tid. Det nye er at dette skjer innen et system hvor inntektssystemet (1986 gir kommunene ansvar for undervisningen, og hvor statens mulighet til å bruke økonomiske styringsmidler er redusert.

  12. AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies.

    Science.gov (United States)

    Kantarci, Kejal; Lowe, Val J; Boeve, Bradley F; Senjem, Matthew L; Tosakulwong, Nikki; Lesnick, Timothy G; Spychalla, Anthony J; Gunter, Jeffrey L; Fields, Julie A; Graff-Radford, Jonathan; Ferman, Tanis J; Jones, David T; Murray, Melissa E; Knopman, David S; Jack, Clifford R; Petersen, Ronald C

    2017-01-01

    Patients with probable dementia with Lewy bodies (DLB) often have Alzheimer's disease (AD)-related pathology. Our objective was to determine the pattern of positron emission tomography (PET) tau tracer AV-1451 uptake in patients with probable DLB, compared to AD, and its relationship to β-amyloid deposition on PET. Consecutive patients with clinically probable DLB (n = 19) from the Mayo Clinic Alzheimer's Disease Research Center underwent magnetic resonance imaging, AV-1451, and Pittsburgh compound-B (PiB) PET examinations. Age- and sex-matched groups of AD dementia (n = 19) patients and clinically normal controls (n = 95) from an epidemiological cohort served as a comparison groups. Atlas- and voxel-based analyses were performed. The AD dementia group had significantly higher AV-1451 uptake than the probable DLB group, and medial temporal uptake completely distinguished AD dementia from probable DLB. Patients with probable DLB had greater AV-1451 uptake in the posterior temporoparietal and occipital cortex compared to clinically normal controls, and in probable DLB, the uptake in these regions correlated with global cortical PiB uptake (Spearman rho = 0.63; p = 0.006). Medial temporal lobe AV-1451 uptake distinguishes AD dementia from probable DLB, which may be useful for differential diagnosis. Elevated posterior temporoparietal and occipital AV-1451 uptake in probable DLB and its association with global cortical PiB uptake suggest an atypical pattern of tau deposition in DLB. ANN NEUROL 2017;81:58-67. © 2016 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

  13. Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT.

    Science.gov (United States)

    Raphael, Claire E; Kyriacou, Andreas; Jones, Siana; Pabari, Punam; Cole, Graham; Baruah, Resham; Hughes, Alun D; Francis, Darrel P

    2013-09-20

    AV delay optimisation of biventricular pacing devices (cardiac resynchronisation therapy, CRT) is performed in trials and recommended by current guidelines. The Doppler echocardiographic iterative method is the most commonly recommended. Yet whether it can be executed reliably has never been tested formally. 36 multinational specialists, familiar with using the echocardiographic iterative method of CRT optimisation, were shown 20-40 sets of transmitral Doppler traces at 6-8 AV settings and asked to select the optimal AV delay. Unknown to the specialists, some Doppler datasets appeared in duplicate, allowing assessment of both inter and intra-specialist interpretation. On the Kappa scale of agreement (1 = perfect agreement, 0 = chance alone), the agreement regarding optimal AV delay between specialists was poor (kappa=0.12 ± 0.08). More importantly, agreement of specialists with themselves (i.e. viewing identical sets of traces, twice) was also poor, with Kappa=0.23 ± 0.07 and mean absolute difference in optimum AV delay of 83 ms between first and second viewing of the same traces. Iterative AV optimisation is not executed reliably by experts, even in an artificially simplified context where biological variability and variation in image acquisition are eliminated by use of identical traces. This cannot be blamed on insufficient skills of some experts or discordant methods of selecting the optimum, because operators also showed poor agreement with themselves when assessing the same trace. Instead, guidelines should retract any recommendation for this algorithm. Guideline-development processes might usefully begin with a rudimentary check on proposed algorithms, to establish at least minimal credibility. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  14. The parsec-scale relationship between ICO and AV in local molecular clouds

    Science.gov (United States)

    Lee, Cheoljong; Leroy, Adam K.; Bolatto, Alberto D.; Glover, Simon C. O.; Indebetouw, Remy; Sandstrom, Karin; Schruba, Andreas

    2018-03-01

    We measure the parsec-scale relationship between integrated CO intensity (ICO) and visual extinction (AV) in 24 local molecular clouds using maps of CO emission and dust optical depth from Planck. This relationship informs our understanding of CO emission across environments, but clean Milky Way measurements remain scarce. We find uniform ICO for a given AV, with the results bracketed by previous studies of the Pipe and Perseus clouds. Our measured ICO-AV relation broadly agrees with the standard Galactic CO-to-H2 conversion factor, the relation found for the Magellanic clouds at coarser resolution, and numerical simulations by Glover & Clark (2016). This supports the idea that CO emission primarily depends on shielding, which protects molecules from dissociating radiation. Evidence for CO saturation at high AV and a threshold for CO emission at low AV varies remains uncertain due to insufficient resolution and ambiguities in background subtraction. Resolution of order 0.1 pc may be required to measure these features. We use this ICO-AV relation to predict how the CO-to-H2 conversion factor (XCO) would change if the Solar Neighbourhood clouds had different dust-to-gas ratio (metallicity). The calculations highlight the need for improved observations of the CO emission threshold and H I shielding layer depth. They are also sensitive to the shape of the column density distribution. Because local clouds collectively show a self-similar distribution, we predict a shallow metallicity dependence for XCO down to a few tenths of solar metallicity. However, our calculations also imply dramatic variations in cloud-to-cloud XCO at subsolar metallicity.

  15. Vegetasjonskartlegging av Muddvær, Vegaøyan verdensarv, Vega kommune

    OpenAIRE

    Bär, Annette; Carlsen, Thomas

    2009-01-01

    Muddværet ble vegetasjonskartlagt for å få oversikt over de botaniske verdiene. Vegetasjonstyper etter Fremstad (1997) er framstilt på kart og rapporten inneholder i tillegg en artsliste over registrerte planter. Kartleggingen skal brukes som grunnlag for en senere utarbeiding av en skjøtselsplan for området og ses i sammenheng med tidligere kartlegginger og utarbeiding av skjøtselsplaner for Vegaøyan verdensarvområde (bl.a. Hatten m.fl. 2007; Hatten & Carlsen 2007a,b).

  16. Fromleik i Black Supper, Piss Christ og Crucifixion, tre fotografi av Andres Serrano

    OpenAIRE

    Vinje, Lilly

    2006-01-01

    Oppgåva skal omhandla tre utvalgte foto av fotografen Andres Serrano, ein amerikanar født i 1950. Enkeltbileta det er snakk om er Black Supper (1990), Piss Christ og Crucifixion (begge 1987). Dei er laga ved at kitschfigurar er nedsenka i gjennomsiktige behaldarar fyllte av kroppsvæsker og vatn; vatn i Black Supper, urin i Piss Christ og blod i Crucifixion. Henholdsvis framstiller dei Nattverden, Jesus på krossen og Krossfestinga (tre figurar). Serrano befinn seg med desse innanfor religiøs k...

  17. Forensisk analys av volatilt minne från operativsystemet OS X

    OpenAIRE

    Ogeskär, Tobias

    2014-01-01

    Behovet av att analysera volatilt minne från Macintosh-datorer med OS X har blivit allt mer betydelsefull på grund av att deras datorer blivit allt populärare och att volatil minnesanalysering blivit en allt viktigare del i en IT-forensikers arbete. Anledningen till att volatil minnesanalysering blivit allt viktigare är för att det går att finna viktig information som inte finns lagrad permanent på datorns interna hårddisk. Problemet som låg till grunden för det här examensarbetet var att det...

  18. Mellom risiko og kontroll - en studie av eksplisitte modelleringsformer i norsk grunnskolelærerutdanning

    Directory of Open Access Journals (Sweden)

    Fride Lindstøl

    2017-12-01

    Full Text Available Å være lærerutdanner skiller seg fra andre stillinger innenfor høyere utdanning: Lærerutdanneren underviser både i fagstoff og i hvordan studentene kan lære bort og adaptere fagstoffet i klasserommet. Det at lærerutdanneren underviser i det å undervise, har implikasjoner for hvordan undervisningen planlegges, gjennomføres og analyseres i lærerutdanningen – undervisningens form blir en del av budskapet. Lærerutdannerens arbeid handler derfor om å utforme, velge og sette i spill aktiviteter og oppgaver som kan adaptere fag, forskning, didaktikk og teori til klasserom og profesjonen. Utforming og montasje av de ulike delene eller episodene i et undervisningsforløp kan betegnes som undervisningsforløpets dramaturgi. I denne artikkelen har jeg gjort en dramaturgisk analyse av tre lærerutdanneres undervisning for å identifisere og beskrive hvordan de bruker eksplisitte modelleringsformer, og hva som skjer når de bruker dem. I etterkant av den dramaturgiske analysen har jeg gjort en konvensjonell innholdsanalyse av intervjudata for å undersøke hvordan lærerutdannerne selv forklarer formålet og erfaringer med å bruke eksplisitt modellering i undervisningen. Analyse av tre lærerutdanneres undervisningspraksis sammenfattes i en modelleringsstige som visualiserer hvordan enkelte former for eksplisitte modelleringsformer tilbyr en egen sirkulær dramaturgi. Studien antyder og drøfter også på hvilken måte modelleringsstigen kan fungere som en dramaturgisk modell, som kan brukes som utgangspunkt for lærerutdanneres planlegging, gjennomføring og analyse av egen undervisning. Studien er et bidrag til å utvikle og forske på hvordan eksplisitte modelleringsformer kan brukes for å skape sammenheng mellom praktisk lærerarbeid og teoretisk metarefleksjon i lærerutdannerens undervisning. Innsamling av data er gjort i profesjonsverksted, som kan forklares som en læringsarena hvor lærerutdannere fra ulike fag samarbeider om

  19. Rate-adaptive AV delay and exercise performance following cardiac resynchronization therapy.

    Science.gov (United States)

    Shanmugam, Nesan; Prada-Delgado, Oscar; Campos, Ana Garcia; Grimster, Alex; Valencia, Oswaldo; Baltabaeva, Aigul; Jones, Sue; Anderson, Lisa

    2012-11-01

    Physiological shortening of the atrioventricular (AV) interval with increasing heart rate is well documented in normal human beings and is an established component of dual-chamber pacing for bradycardia. To assess the effect of exercise on optimal AV delay and the impact of a patient-specific rate-adaptive AV delay (RAAVD) on exercise capacity in patients with heart failure following cardiac resynchronization therapy. Phase 1: We performed iterative AV optimization at rest and exercise in 52 cardiac resynchronization therapy patients in atrial-sensed mode (mean age 71.6 ± 9.2 years, 25% females). Phase 2: Subsequently, 20 consecutive volunteers from this group (mean age 69.2 ± 9.6 years, 15% females) underwent cardiopulmonary exercise testing with RAAVD individually programmed ON (RAAVD-ON) or OFF (RAAVD-OFF). Phase 1: In 94% of the patients, there was a marked reduction (mean 50%) in optimal AV delay with exercise. The optimal resting vs exercise AV delay was 114.2 ± 29 ms at a heart rate of 64.4 ± 7.1 beats/min vs 57 ± 31 ms at a heart rate of 103 ± 13 beats/min (P AV delay with exercise, and 3 (6%) showed no change. Phase 2: With RAAVD-ON, significantly better exercise times were achieved (8.7 ± 3.2 minutes) compared with RAAVD-OFF (7.9 ± 3.2 minutes; P = .003), and there was a significant improvement in Vo(2)max (RAAVD-ON 16.1 ± 4.0 vs RAAVD-OFF 14.9 ± 3.7 mL/(kg · min); P = .024). There was a dramatic reduction in optimal AV delay with physiological exercise in the majority of this heart failure cardiac resynchronization therapy cohort. Replicating this physiological response with a programmable RAAVD translated into a 10% improvement in exercise capacity. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  20. Correlliansk Wicca -En analyse av et nyreligiøst trossamfunn i vekst-

    OpenAIRE

    Johansen, Monica Frankrig

    2015-01-01

    Correlliansk wicca er en tradisjon innenfor wicca som baserer sin praksis på læren til High- Correll familien. Den correllianske wicca- tradisjonen ble grunnlagt av Caroline High- Correll. Correllianere anser seg selv for å være åpne for mange ulike livssyn og praksiser. De tror at det guddommelige kommer innenfra oss selv, og at religion eksisterer for å hjelpe oss til å finne det guddommelige i hver av oss, og ikke for å forsøke å erstatte denne guddommeligheten. Correllianere mener at alle...

  1. Hvordan gjøre tenking synlig ved bruk av interaktive modeller på vitensenter?

    OpenAIRE

    Stav, Torun Vaagland

    2015-01-01

    Det er et økende antall forskningsstudier som fokuserer på læringsutbytte ved vitensentre og liknende institusjoner (Kisiel, 2013). EEET (European Exhibition Evaluation Tool) er et slikt bidrag. Dette er et vurderingsverktøy som blant annet er laget for å kartlegge bruken av interaktive modeller ved vitensentre. EEETer en av to metoder som skal bidra til å besvare denne studiens problemstilling. Den andre metoden, UM (Understanding Map) er basert på åtte tegn på forståelse som beskrevet i bok...

  2. Konstruktion av vertikaltransportör för materialhantering

    OpenAIRE

    Furu, Micke

    2012-01-01

    Rotab Rostfria Transportörer AB tillverkar och utvecklar material- och godshanteringsutrustning. Företaget levererar även kompletta materialhanteringslösningar i form av godshanteringsanläggningar som ofta består av transportband och paketeringsutrustning. Examensarbetets mål är att utveckla en vertikaltransportör som ska transportera gods mellan två transportband belägna på olika höjder, transporten ska kunna varieras mellan 1000 - 3000 mm. Transportören ska undvika de två stora nackdelarna ...

  3. Att vara ung vuxen med reumatism : Psykologiska aspekter av reumatisk sjukdom

    OpenAIRE

    Fröberg, Tove

    2015-01-01

    Kunskapen gällande hur det upplevs att vara ung vuxen och samtidigt ha en reumatisk sjukdom är begränsad. Syftet med denna kvalitativa studie var att utifrån individens eget perspektiv försöka fånga in och beskriva olika psykologiska aspekter av att vara ung vuxen och samtidigt ha reumatism, i en svensk kontext. Studien utfördes på sju reumatiker i åldern 18-40 och datainsamligen bestod av semistrukturerade intervjuer. Analysen följde ett induktivt tematiskt mönster. I studien identifierades ...

  4. Indeksering av og søking i hierarkiske metadata i XML-database

    OpenAIRE

    Ingebretsen, Knut Bjørke

    2005-01-01

    Denne oppgaven ser på hvordan en XML-database kan brukes til indeksering av og søking i hierarkiske metadata. Dette inngår som en del av arbeidet med å gjøre informasjon fra forskjellige samlinger tilgjengelig for informasjonssøkere. Problemstillingen det har vært arbeidet med er delt i to. Den ene delen var å finne ut hvordan en XML-database kan brukes som lokal indeks for metadata på et hierarkisk format. Den andre delen var å finne ut hvordan et søkegrensesnitt kan utvides til å utnytte h...

  5. Manliga och kvinnliga teknologers självbilder och deras stereotypbilder av teknologer

    Directory of Open Access Journals (Sweden)

    Charlotte Soneson

    2013-01-01

    Full Text Available Självbild och bilden av en typisk teknolog undersöktes hos civilingenjörsstudenter på LTH med personlighetstestet Adjective Check List. Vi fann stora skillnader mellan självbild och stereotypbild. Undersökningen visade också att dessa skillnader till viss del såg olika ut bland manliga och kvinnliga studenter, och skillnaden mellan kvinnornas genomsnittliga självbild och deras genomsnittliga bild av en typisk teknolog var då större än motsvarande skillnad bland männen.

  6. First-degree AV block-an entirely benign finding or a potentially curable cause of cardiac disease?

    Science.gov (United States)

    Holmqvist, Fredrik; Daubert, James P

    2013-05-01

    First-degree atrioventricular (AV) block is a delay within the AV conduction system and is defined as a prolongation of the PR interval beyond the upper limit of what is considered normal (generally 0.20 s). Up until recently, first-degree AV block was considered an entirely benign condition. In fact, some complain that it is a misnomer since there is only delay and no actual block in the AV conduction system (usually within the AV node). However, it has long been acknowledged that extreme forms of first-degree AV block (typically a PR interval exceeding 0.30 s) can cause symptoms due to inadequate timing of atrial and ventricular contractions, similar to the so-called pacemaker syndrome. Consequently, the current guidelines state that permanent pacemaker implantation is reasonable for first-degree AV block with symptoms similar to those of pacemaker syndrome or with hemodynamic compromise, but also stresses that there is little evidence to suggest that pacemakers improve survival in patients with isolated first-degree AV block. Recent reports suggest that it may be time to revisit the impact of first-degree AV block. Also, several findings in post hoc analyses of randomized device trials give important insights in possible treatment options. The present review aims to provide an update on the current knowledge concerning the impact of first-degree AV block and also to address the issue of pacing in patients with this condition. ©2013, Wiley Periodicals, Inc.

  7. Patients' and procedural characteristics of AV-block during slow pathway modulation for AVNRT-single center 10year experience.

    Science.gov (United States)

    Wasmer, Kristina; Dechering, Dirk G; Köbe, Julia; Leitz, Patrick; Frommeyer, Gerrit; Lange, Phillip S; Kochhäuser, Simon; Reinke, Florian; Pott, Christian; Mönnig, Gerold; Breithardt, Günter; Eckardt, Lars

    2017-10-01

    Permanent AV-block is a recognized and feared complication of slow pathway modulation for AVNRT. We aimed to assess incidence of transient and permanent AV-block as well as consequences of transient AV-block in a large contemporary AVNRT ablation cohort. We searched our single center prospective ablation database for occurrence of transient and permanent AV-block during slow pathway modulation between January 2004 and October 2015. We analyzed patients' and procedural characteristics as well as outcome of patients in whom transient or permanent AV-block occurred. Of 9170 patients who underwent a catheter ablation at our institution between January 2004 and October 2015, 2101 patients (64% women, mean age 50±18years) underwent slow pathway modulation. In three patients, permanent AV-block occurred during RF application. Additional two patients had transient AV-block that recovered (after a few minutes and 25min), but recurred within two days of the procedure. All five patients underwent dual chamber pacemaker implantation (0.2%). Transient AV-block related to RF delivery occurred in 44 patients (2%). Transient mechanical AV-block occurred in additional 17 patients (0.8%). In 12 patients, ablation was continued despite transient AV-block. One of these patients developed permanent AV-block. Permanent AV-block following slow pathway modulation is a rare event, occurring in 0.2% of patients in a large contemporary single center cohort. Transient AV-block is more frequent (2%). Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Vad var det som hände? Efterbearbetning av en simulering för utvecklande av professionell kunskap hos polisstudenter

    Directory of Open Access Journals (Sweden)

    David Sjöberg

    2014-11-01

    Full Text Available Att öva för att lära sig att hantera polisiära situationer utgör ett viktigt inslag i polisstudenters utbildning. Lärandet sker genom praktiska övningar t.ex. drillövningar och övningar av specifika moment men även via simuleringar där studenter agerar som polis i mera komplexa situationer. Simuleringar är inte unika för polisutbildning utan utgör ett vanligt inslag i professionsutbildning genom sin koppling till "verkliga" situationer (Peters och Vissers, 2004; Lederman, 1984. Under de senaste årtiondena har simuleringar använts för utbildning inom så skilda professionsfält som medicin och hälsovård, flyg och blåljusverksamhet. Simuleringar kan vara av skiftande karaktär t.ex. fysiska i form av rollspel men även datorbaserade. Simuleringar kan syfta till att utveckla en specifik färdighet (se t.ex. Windsor, 2009; Stefanidis, Acker, och Heniford, 2008; Wallin, Meurling, Hedman, Hedengård, och Felländer-Tsai, 2007, som t ex att lära sig hur man avläser röntgenbilder (se t.ex. Söderström, Häll, Nilsson, och Ahlqvist 2012 eller till att lära hur man ska agera i komplexa situationer (Andersson, Carlström, och Berlin, 2013; Bauman, Gohm och Bonner, 2011, t.ex. vid svåra olyckshändelser med många personer inblandade (se t.ex. McConnell och Drennan, 2006. Simuleringar av komplexa situationer med många inblandade brukar benämnas som fullskaliga (se t.ex. Andersson, Carlström, och Berlin, 2013. Simuleringar antas träna och utveckla professionell kunskap genom att förbereda studenter på att hantera komplexa och ibland farliga situationer som de kan komma att ställas inför i en kommande yrkespraktik. Användningen av simuleringar i utbildningar bygger således på ett antagande om överföring av erfarenheter och kunskaper från ett sammanhang till ett annat (se t.ex. Söderström, Åström, Anderson och Bowles, 2014. I den här artikeln utgår vi från simulering som en utbildningsresurs där deltagarna

  9. Vannmagasinet er ikke fullt før det renner over : en analyse av effekten av redusert etterspørsel i et vannkraftsystem, eksemplifisert med energieffektivisering i bygninger

    OpenAIRE

    Siljan, Marte

    2010-01-01

    Energieffektivisering i bygninger regnes som et av de mest kostnadseffektive tiltakene for å redusere forbruk av energi, samt bidra til reduksjon i klimagassutslipp. I følge rapporter fra blant annet Lavenergiutvalget (2009) og Klimakur 2020 (2010), vil det være mulig å frigjøre rundt 10 TWh elektrisitet fra norske bygninger i løpet av de neste ti årene. Denne masteroppgaven tar for seg følgene av en tilsvarende etterspørselsreduksjon i det norske kraftsystemet. Norge har et kraftsystem med n...

  10. Trace metals in floodplain lake sediments : SEM/AVS as indicator of bioavailability and ecological effects

    NARCIS (Netherlands)

    Griethuysen, van C.

    2006-01-01

    This thesis addresses the geochemical aspects of AVS (Acid Volatile Sulfide) and SEM (Simultaneously Extracted Metals) in floodplain lake sediment, its spatial distribution in floodplain lakes and dynamics over time, the link with effects on single species (bioassays), as well as the impact of

  11. In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography.

    Science.gov (United States)

    Hansen, Allan K; Damholdt, Malene Flensborg; Fedorova, Tatyana D; Knudsen, Karoline; Parbo, Peter; Ismail, Rola; Østergaard, Karen; Brooks, David J; Borghammer, Per

    2017-06-01

    Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. To describe tau aggregation in PD patients. Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment. Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society. © 2017 International Parkinson and Movement Disorder Society.

  12. A-V Delay Versus Cardiac Output Measured with Thorax Bioimpedance Monitor

    Czech Academy of Sciences Publication Activity Database

    Vondra, Vlastimil; Halámek, Josef; Viščor, Ivo; Jurák, Pavel; Novák, M.; Lipoldová, J.

    2008-01-01

    Roč. 6, č. 1 (2008), s. 73 ISSN 1556-7451. [World Congress on Heart Disease /14./. 26.07.2008-29.07.2008, Toronto] Institutional research plan: CEZ:AV0Z20650511 Keywords : atrio -ventricular delay * resynchronization therapy * impedance cardiography * cardiac output Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  13. Identification of a potential toxic hot spot associated with AVS spatial and seasonal variation.

    Science.gov (United States)

    Campana, O; Rodríguez, A; Blasco, J

    2009-04-01

    In risk assessment of aquatic sediments, much attention is paid to the difference between acid-volatile sulfide (AVS) and simultaneously extracted metals (SEMs) as indicators of metal availability. Ten representative sampling sites were selected along the estuary of the Guadalete River. Surficial sediments were sampled in winter and summer to better understand SEM and AVS spatial and seasonal distributions and to establish priority risk areas. Total SEM concentration (SigmaSEM) ranged from 0.3 to 4.7 micromol g(-1). It was not significantly different between seasons, however, it showed a significant difference between sampling stations. AVS concentrations were much more variable, showing significant spatial and temporal variations. The values ranged from 0.8 to 22.4 micromol g(-1). The SEM/AVS ratio was found to be <1 at all except one station located near the mouth of the estuary. The results provided information on a potential pollution source near the mouth of the estuary, probably associated with vessel-related activities carried out in a local harbor area located near the station.

  14. Nové elektronické knihy v Knihovně AV ČR

    Czech Academy of Sciences Publication Activity Database

    Meixner, Jaroslav; Krouzová, Lucie

    -, č. 2 (2014) E-ISSN 1805-2800 Keywords : electronic books * Academy of Sciences Lib rary Subject RIV: AF - Documentation, Lib rarianship, Information Studies http://www. lib .cas.cz/casopis-informace/nove-elektronicke-knihy-v-knihovne-av-cr/

  15. Impact of e-AV Biology Website for Learning about Renewable Energy

    Science.gov (United States)

    Nugraini, Siti Hadiati; Choo, Koo Ah; Hin, Hew Soon; Hoon, Teoh Sian

    2013-01-01

    This paper considers the design and development of a Website for Biology in senior high schools in Indonesia. The teaching media, namely e-AV Biology, was developed with the main features of video lessons and other features in supporting the students' learning process. Some video lessons describe the production process of Biofuel or Renewable…

  16. Problematika romské migrace v Etnologickém ústavu AV ČR

    Czech Academy of Sciences Publication Activity Database

    Uherek, Zdeněk

    2007-01-01

    Roč. 10, č. 3 (2007), s. 1-7 ISSN 1335-3608 Institutional research plan: CEZ:AV0Z90580513 Keywords : migration * Roma * Institute of Ethnology of the Academy of Sciences of the Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology http://www.saske.sk/cas/3-2007/index.html

  17. ECG of the "Newborn" Mouse (Mus domesticus) with Specific Reference to Comparative AV Transmission

    NARCIS (Netherlands)

    Tweel, L.H. van der; Strackee, J.; Stokhof, A.A.; Wassenaar, C.; Meijler, F.L.

    1999-01-01

    The objective of this study was to record the ECG of the smallest living mammal to extend the domain of data for comparative AV-nodal electrophysiologic purposes. These data are needed to establish the relationship between the PR interval and heart size in mammalian species of all sizes. Methods

  18. Identification of the human ApoAV gene as a novel RORα target gene

    International Nuclear Information System (INIS)

    Lind, Ulrika; Nilsson, Tina; McPheat, Jane; Stroemstedt, Per-Erik; Bamberg, Krister; Balendran, Clare; Kang, Daiwu

    2005-01-01

    Retinoic acid receptor-related orphan receptor-α (RORα) (NR1F1) is an orphan nuclear receptor with a potential role in metabolism. Previous studies have shown that RORα regulates transcription of the murine Apolipoprotein AI gene and human Apolipoprotein CIII genes. In the present study, we present evidence that RORα also induces transcription of the human Apolipoprotein AV gene, a recently identified apolipoprotein associated with triglyceride levels. Adenovirus-mediated overexpression of RORα increased the endogenous expression of ApoAV in HepG2 cells and RORα also enhanced the activity of an ApoAV promoter construct in transiently transfected HepG2 cells. Deletion and mutation studies identified three AGGTCA motifs in the ApoAV promoter that mediate RORα transactivation, one of which overlaps with a previously identified binding site for PPARα. Together, these results suggest a novel mechanism whereby RORα modulates lipid metabolism and implies RORα as a potential target for the treatment of dyslipidemia and atherosclerosis

  19. HPCMP CREATE (trademark)-AV Quality Assurance: Best Practices for Validating and Supporting Computation-Based Engineering Software

    Science.gov (United States)

    2015-09-30

    30/2015 Oct 2008-Sep 2015 HPCMP CREATE™- AV Quality Assurance: Best Practices for Validating and Supporting Computation-Based Engineering Software...2) “Does this tool adequately perform any and all advertised capabilities?” This paper will describe how the HPCMP CREATE Air Vehicles ( AV ...discussed and their strengths and weaknesses within the CREATE- AV framework addressed. Work toward the HPCMP CREATE, Quality Assurance, Aviation

  20. A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

    Science.gov (United States)

    van Stigt, Arthur H; Overduin, Ruben J; Staats, Liza C; Loen, Vera; van der Heyden, Marcel A G

    2016-02-29

    Acute excessive alcohol consumption is associated with heart rhythm disorders like atrial fibrillation but also premature ventricular contractions, collectively known as the "holiday heart syndrome". More rarely but clinically significant are reports of atrioventricular (AV) conduction disturbances in binge drinkers with no underlying heart disease or chronic alcohol consumption. To obtain better insights into common denominators and the potential underlying mechanisms we collected and compared individual case reports of AV block following acute alcohol intoxication in otherwise healthy people. By screening PubMed, Google Scholar, Scopus and JSTOR, fifteen cases were found of which eight were sufficiently documented for full analysis. Blood alcohol levels ranged from 90 to 958 mg/dl (19 to 205 mM). Second and third degree AV block was observed most (6/8) albeit that in two of these patients a vagal stimulus led to deterioration from first into higher order AV block. In all cases, patients reverted to normal sinus rhythm upon becoming sober again. Mildly lowered body temperature (35.9 ± 0.5°C) was observed but can be excluded as a major cause of conduction blockade. We hypothesize that ethanol induced partial inhibition of calcium and potentially also sodium currents in conductive tissue structures may be one of the mechanisms of conduction slowing and block that may become exaggerated upon increased vagal tone. An impairment of gap junction function cannot be excluded as a contributing factor. In conclusion, cases of documented alcohol induced AV block are very rare but events can occur at relatively low serum alcohol levels which should prompt to awareness of this phenomenon in alcohol intoxicated patients.

  1. AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure.

    Science.gov (United States)

    Mishra, Shruti; Gordon, Brian A; Su, Yi; Christensen, Jon; Friedrichsen, Karl; Jackson, Kelley; Hornbeck, Russ; Balota, David A; Cairns, Nigel J; Morris, John C; Ances, Beau M; Benzinger, Tammie L S

    2017-11-01

    Utilizing [18F]-AV-1451 tau positron emission tomography (PET) as an Alzheimer disease (AD) biomarker will require identification of brain regions that are most important in detecting elevated tau pathology in preclinical AD. Here, we utilized an unsupervised learning, data-driven approach to identify brain regions whose tau PET is most informative in discriminating low and high levels of [18F]-AV-1451 binding. 84 cognitively normal participants who had undergone AV-1451 PET imaging were used in a sparse k-means clustering with resampling analysis to identify the regions most informative in dividing a cognitively normal population into high tau and low tau groups. The highest-weighted FreeSurfer regions of interest (ROIs) separating these groups were the entorhinal cortex, amygdala, lateral occipital cortex, and inferior temporal cortex, and an average SUVR in these four ROIs was used as a summary metric for AV-1451 uptake. We propose an AV-1451 SUVR cut-off of 1.25 to define high tau as described by imaging. This spatial distribution of tau PET is a more widespread pattern than that predicted by pathological staging schemes. Our data-derived metric was validated first in this cognitively normal cohort by correlating with early measures of cognitive dysfunction, and with disease progression as measured by β-amyloid PET imaging. We additionally validated this summary metric in a cohort of 13 Alzheimer disease patients, and showed that this measure correlates with cognitive dysfunction and β-amyloid PET imaging in a diseased population. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Videodokumentasjon ved gjennomføring av praktisk eksamen i sykepleie - hvordan kan dette forbedre studentens praksiske ferdigheter?

    Directory of Open Access Journals (Sweden)

    Gjertrud Husøy

    2014-02-01

    Full Text Available Hensikten med studiet var å belyse hvordan videodokumentasjon av praktiske handlinger i sykepleie kunne brukes som evalueringordning av studenter. Artikkelen tar utgangspunkt i et forskningsprosjekt for utprøving av nye lærings og evalueringsformer i bachelorutdanningen i sykepleie, der 13 studentgrupper gjennomførte sin praktiske eksamen ved innlevering av video av 16 utvalgte øvelser. Tradisjonell praktisk eksamen i samme studentkull ble gjennomført for 10 studentgrupper. Prosjektet er en kvalitativ kasusstudie og analyse er gjort etter inspirasjon av Giorgi‘s empiriske fenomenologi. Diskusjonen tar utgangspunkt i Vygotsky‘s sosiokulturelle syn på læring og Dewey‘s prinsipp om at all læring er basert på erfaring. Funnene er presentert i følgende deler: Første del omhandler videodokumentasjon og refleksjon. De to neste delene viser funn i forhold til mesterlæring og situert læring på vei mot forståelse av hva sykepleie er. Deretter er teknisk utfordringer belyst, og til slutt en drøfting av forhold ved oppøving av praktiske sykepleieferdigheter. Konklusjonen her er at video egner seg til å dokumentere sykepleiehandlinger. Dette har størst verdi for læring og refleksjon, i mindre grad som eksamensform.

  3. Skladování energie – téma v hledáčku AV ČR

    Czech Academy of Sciences Publication Activity Database

    Bendová, Magdalena; Hrubý, Jan; Chomát, Miroslav; Zima, Patrik

    -, č. 2 (2016), s. 7-9 ISSN 1210-9525. [Technology Perspectives for Energy Storage. Praha, 30.11.2015] Grant - others:AV ČR(CZ) StrategieAV21/3 Program:StrategieAV Institutional support: RVO:61388998 ; RVO:67985858 Keywords : energy storage * renewable energy sources * strategy AV21 initiative Subject RIV: CF - Physical ; Theoretical Chemistry

  4. The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity.

    Science.gov (United States)

    Bailleul, Geoffrey; Kravtzoff, Amanda; Joulin-Giet, Alix; Lecaille, Fabien; Labas, Valérie; Meudal, Hervé; Loth, Karine; Teixeira-Gomes, Ana-Paula; Gilbert, Florence B; Coquet, Laurent; Jouenne, Thierry; Brömme, Dieter; Schouler, Catherine; Landon, Céline; Lalmanach, Gilles; Lalmanach, Anne-Christine

    2016-01-01

    Defensins are frontline peptides of mucosal immunity in the animal kingdom, including birds. Their resistance to proteolysis and their ensuing ability to maintain antimicrobial potential remains questionable and was therefore investigated. We have shown by bottom-up mass spectrometry analysis of protein extracts that both avian beta-defensins AvBD2 and AvBD7 were ubiquitously distributed along the chicken gut. Cathepsin B was found by immunoblotting in jejunum, ileum, caecum, and caecal tonsils, while cathepsins K, L, and S were merely identified in caecal tonsils. Hydrolysis product of AvBD2 and AvBD7 incubated with a panel of proteases was analysed by RP-HPLC, mass spectrometry and antimicrobial assays. AvBD2 and AvBD7 were resistant to serine proteases and to cathepsins D and H. Conversely cysteine cathepsins B, K, L, and S degraded AvBD2 and abolished its antibacterial activity. Only cathepsin K cleaved AvBD7 and released Ile4-AvBD7, a N-terminal truncated natural peptidoform of AvBD7 that displayed antibacterial activity. Besides the 3-stranded antiparallel beta-sheet typical of beta-defensins, structural analysis of AvBD7 by two-dimensional NMR spectroscopy highlighted the restricted accessibility of the C-terminus embedded by the N-terminal region and gave a formal evidence of a salt bridge (Asp9-Arg12) that could account for proteolysis resistance. The differential susceptibility of avian defensins to proteolysis opens intriguing questions about a distinctive role in the mucosal immunity against pathogen invasion.

  5. Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake.

    Science.gov (United States)

    Das, Sandhitsu R; Xie, Long; Wisse, Laura E M; Ittyerah, Ranjit; Tustison, Nicholas J; Dickerson, Bradford C; Yushkevich, Paul A; Wolk, David A

    2018-02-09

    We examined the relationship between in vivo estimates of tau deposition as measured by 18 F-AV-1451 tau positron emission tomography imaging and cross-sectional cortical thickness, as well as rates of antecedent cortical thinning measured from magnetic resonance imaging in individuals with and without evidence of cerebral amyloid in 63 participants from the Alzheimer's Disease Neuroimaging Initiative study, including 32 cognitively normal individuals (mean age 74 years), 27 patients with mild cognitive impairment (mean age 76.8 years), and 4 patients diagnosed with Alzheimer's disease (mean age 80 years). We hypothesized that structural measures would correlate with 18 F-AV-1451 in a spatially local manner and that this correlation would be stronger for longitudinal compared to cross-sectional measures of cortical thickness and in those with cerebral amyloid versus those without. Cross-sectional and longitudinal estimates of voxelwise atrophy were made from whole brain maps of cortical thickness and rates of thickness change. In amyloid-β-positive individuals, the correlation of voxelwise atrophy across the whole brain with a summary measure of medial temporal lobe (MTL) 18 F-AV-1451 uptake demonstrated strong local correlations in the MTL with longitudinal atrophy that was weaker in cross-sectional analysis. Similar effects were seen in correlations between 31 bilateral cortical regions of interest. In addition, several nonlocal correlations between atrophy and 18 F-AV-1451 uptake were observed, including association between MTL atrophy and 18 F-AV-1451 uptake in parietal lobe regions of interest such as the precuneus. Amyloid-β-negative individuals only showed weaker correlations in data uncorrected for multiple comparisons. While these data replicate previous reports of associations between 18 F-AV-1451 uptake and cross-sectional structural measures, the current results demonstrate a strong relationship with longitudinal measures of atrophy. These data

  6. 77 FR 41400 - AV Solar Ranch 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2012-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AV Solar Ranch 1, LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding of AV Solar Ranch 1, LLC's application for market-based rate authority, with an...

  7. Specialized treatment for Avoidant personality disorder (AvPD): Treatment rationales and preliminary results

    DEFF Research Database (Denmark)

    Simonsen, Sebastian

    and preliminary results from a specialized psychotherapy program developed for patients with AvPD treated at Stolpegaard Psychotherapy Centre, Capital Region of Denmark. Methods: Treatment consists of individual therapy based on Metacognitive Interpersonal Therapy (MIT) while group therapy is a modified form......½-years of therapy. We focus on how patients change in regards to important outcomes, including both acute symptoms and more personality based problems such as self-reflection, interpersonal problems and ability to describe feelings. Conclusions: Consistency of results with regard to theories about Av...... naturalistic study, we followed patients from start to end of psychotherapy on a range of self-report measures including the SCL-90-R, IIP-C, SIPP-118 and TAS-20. Results: In this preliminary report, we report findings from various time points of therapy: Baseline, 6 months, 12 months and after approximately 1...

  8. Varumärkesvärdering : Implementeringen av IAS 38 och IFRS 3

    OpenAIRE

    Calmfors, Cecilia

    2007-01-01

    Den 1:a januari 2005 infördes nya redovisningsregler gällande företagsförvärv. Samtliga svenska börsnoterade företag skall redovisa i enlighet med IFRS 3 Företagsförvärv och IAS 38 Immateriella tillgångar. De nya reglerna innebär bland annat att varumärken och andra immateriella tillgångar skall värderas separat från goodwill i balansräkningen. Syftet med uppsatsen är att undersöka effekten av IAS 38 på svenska företags redovisning av immateriella tillgångar, med fokus på varumärken. Studien ...

  9. Övervakning av switchar och övrig nätverksutrustning

    OpenAIRE

    Björknäs, Jimmy

    2015-01-01

    Mitt examensarbete har gått ut på att förena trafikgrafer och alarmering av nätverksutrustning som inte är nåbar till samma ställe, samt underlätta processen att lägga till eller ta bort en enhet från övervakningen. Tidigare har två olika program använts för uppgifterna, vilket betyder enheterna ska läggas till på två olika ställen samt att en del enheter inte har varit möjliga att övervaka där. I arbetet jämförde jag programmen Nagios, Icinga, openNMS och Observium. Vissa av dessa program va...

  10. Optimering av nanocellulosa för tillämpning som papperstyrkeadditiv

    OpenAIRE

    Englöf, Johan

    2015-01-01

    Syftet med projektet var att undersöka hur homogeniserings förhållanden (tryck antal passager och därmed energiinsatsen) vid framställning av MFC (mikrofibrillär cellulosa), från enzymatiskt förbehandlade pappersmassafibrer påverkar hållfastheten av papper förstärkt med MFC. Arbetsgivaren för projektet var Innventia och det laborativa arbetet har utförts i deras lokaler. Fördelen med att använda MFC som tillsats i papper är att arket blir starkare [1]. Detta medför att en mindre mängd materia...

  11. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET.

    Science.gov (United States)

    Hansen, Allan K; Knudsen, Karoline; Lillethorup, Thea P; Landau, Anne M; Parbo, Peter; Fedorova, Tatyana; Audrain, Hélène; Bender, Dirk; Østergaard, Karen; Brooks, David J; Borghammer, Per

    2016-07-01

    The tau tangle ligand (18)F-AV-1451 ((18)F-T807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. Parkinson's disease is characterized by progressive loss of dopaminergic neurons. Extrapolation of post-mortem data predicts that a ∼30% decline of nigral dopamine neurons is necessary to cause motor symptoms in Parkinson's disease. Putamen dopamine terminal loss at disease onset most likely exceeds that of the nigral cell bodies and has been estimated to be of the order of 50-70%. We investigated the utility of (18)F-AV-1451 positron emission tomography to visualize the concentration of nigral neuromelanin in Parkinson's disease and correlated the findings to dopamine transporter density, measured by (123)I-FP-CIT single photon emission computed tomography. A total of 17 patients with idiopathic Parkinson's disease and 16 age- and sex-matched control subjects had (18)F-AV-1451 positron emission tomography using a Siemens high-resolution research tomograph. Twelve patients with Parkinson's disease also received a standardized (123)I-FP-CIT single photon emission computed tomography scan at our imaging facility. Many of the patients with Parkinson's disease displayed visually apparent decreased (18)F-AV-1451 signal in the midbrain. On quantitation, patients showed a 30% mean decrease in total nigral (18)F-AV-1451 volume of distribution compared with controls (P = 0.004), but there was an overlap of the individual ranges. We saw no significant correlation between symptom dominant side and contralateral nigral volume of distribution. There was no correlation between nigral (18)F-AV-1451 volume of distribution and age or time since diagnosis. In the subset of 12 patients, who also had a (123)I-FP-CIT scan, the mean total striatal dopamine transporter signal was decreased by 45% and the mean total (18)F-AV-1451 substantia nigra volume of distribution was decreased by 33% after

  12. Restaurang i vardagsrummet : En kvalitativ undersökning av fenomenet middagsklubbar

    OpenAIRE

    Ridderheim, Karin

    2012-01-01

    I följande studie undersöks fenomenet middagsklubbar, ett slags hemma-hos-restauranger där matglada amatörkockar bjuder in okända människor på middag i sitt hem. Syftet med studien är att undersöka vilka som lockas av att driva och besöka middagsklubbar samt varför fenomenet blir alltmer populärt i det senmoderna samhället. Materialet utgörs av kvalitativa djupintervjuer med fyra personer som själva driver middagsklubbar. Genom innehållsanalys hittades gemensamma teman, vilka sedan analyserad...

  13. Clapping hands : En analys av emojis i politisk kommunikation på Instagram

    OpenAIRE

    Junefjäll, Jonathan; Nurro, Linnéa

    2017-01-01

    Emojis är ett digitalt uttryckssätt baserade på smileys och emoticons som introducerades i smarta telefoner under 2011 och har sedan dess blivit en integrerad del av många människors vardagliga kommunikation. De används också i politisk kommunikation på sociala medier på samma sätt som en del i ett modernt uttryckssätt. Den här undersökningen tittar på 557 emojis i 300 inlägg gjorda av tre ledande politiska partier – Høyre i Norge, Socialdemokraterna i Sverige och Venstre i Danmark. Syftet är...

  14. Multifaktormodeller på den svenska marknaden - En studie av OMX Stockholm mellan 1996 och 2014

    OpenAIRE

    Hammarfrid, Peter; Henningsson, Tom

    2015-01-01

    Bakgrund:CAPM räcker i flera tillfällen inte till för att estimera framtida avkastning. Vissa av prisavvikelsernafrån CAPM är väldokumenterade och har bestått över tid, vilket har lett till uppkomsten avkorrigerande faktorer. En modell som använder sig av två sådana korrigerande faktorer är Fama ochFrenchs tre-faktormodell. Den har testats flertalet gånger på den svenska marknaden där den visat gehögre förklaringsgrader än CAPM. År 2012 samt år 2014 presenterades två nya multifaktormodeller,s...

  15. Förbättring av tjänsteleverans för konsultbolag

    OpenAIRE

    Samuelsson, Martin; Törnvall, Alexander

    2014-01-01

    Lönsamheten för konsultbolag är beroende av antalet timmar konsulter arbetar vad gäller leveranser i kunduppdrag. Att timmar ej levereras på grund av sjukdom eller överbeläggning påverkar resultatet för bolaget. Konsultbolag där konsulter samma vecka arbetar mot olika kunder och uppdrag, kan ha svårt att synliggöra och följa upp leveranserna vilket kan resultera i inkomstbortfall och försenade leveranser. Hypotesen för detta examensarbete är att visualisering och uppföljning minskar risken ti...

  16. Apoio financeiro oferecido por avós a netos adolescentes

    Directory of Open Access Journals (Sweden)

    Alessandra Ribeiro Ventura Oliveira

    2012-03-01

    Full Text Available Através de uma revisão bibliográfica sistemática da literatura analisou-se a relação entre avós e netos adolescentes com foco nas diferentes formas de apoio financeiro oferecido pelos avós. O levantamento, através das bases de dados eletrônicas MEDLINE/PubMed, LILACS e SciELO, foi concluído com  07 citações afins. Foram identificadas as relações em que o apoio financeiro assumiu papel importante na relação entre ambos os sujeitos, sugerindo compor um estilo de exercer a avosidade.   

  17. Detektion av “troll” i Twitterflöden med hjälp av klusteralgoritm : Metod för att detektera personer som sprider desinformation

    OpenAIRE

    Yousef, Andy; Lansner, Erik

    2016-01-01

    Sociala medier har alltid varit en plats där personer kan diskutera fritt om sina åsikter och dela nyheter med många. Lätt spridning av nyheter från alla hörn i världen kan komma vara användbart för att ha möjlighet att få opartiska nyheter. Även om det finns klara fördelar med exempelvis Twitter så kan det vara problematiskt med falska och uppgjorda nyheter. Ryktesspridning eller uppgjorda nyheter förekommer i stor utsträckning fortfarande, här testas metod(er) för att upptäcka vilka som kan...

  18. Pedagogiske lederes erfaringer med og forebygging av begynnende mobbeatferd i barnehagen.

    OpenAIRE

    Alfsvåg, Anna

    2017-01-01

    Master's thesis in Special education Studiens tema er barns begynnende mobbeatferd, og hvordan dette erfares og forebygges av fire pedagogiske ledere i barnehager. Teoretiske perspektiver som belyser temaets perspektiver og kompleksitet er begrepene vold eller mobbing (Isdal, Andreassen & Thilesen, 2003), mobbing i barnehagen (Falck, 2013 og Størksen, 2013), aggresjonsperspektivet (Roland, 2011 og Olweus, 1993), ulike tiltak som kan iverksettes som tidlig innsats (Tremblay, 2010), verdien ...

  19. Frihet & struktur : en kvalitativ studie av skolelivskvalitet hos ungdom med Tourette syndrom

    OpenAIRE

    Siverts, Torstein

    2005-01-01

    Sammendrag. Tittel: Skolelivskvalitet hos ungdom med Tourette Syndrom Med bakgrunn i egen erfaring fra arbeid med elever med Tourette Syndrom i grunnskolen, og i studier i spesialpedagogisk teori og empiri, etterstrebes det i denne studien å utvikle økt forståelse for hva slags erfaringer fra og perspektiver på sitt skoleliv elever med denne funksjonshemmende lidelsen har. Med grunnlag i analyser av intervjuer med elever om deres erfaringer og perspektiver, har jeg prøvd å b...

  20. Språkkartlegging av flerspråklige barn i barnehagen - fra kontrovers til kompromiss?

    Directory of Open Access Journals (Sweden)

    Nassira Essahli Vik

    2017-07-01

    Full Text Available Språkkartlegging i barnehagen er et konfliktfylt felt som preges av enten/eller tenkning. På den ene siden ser kartleggingstilhengerne ut til å ha en positivistisk tro på at kartlegging kan bidra til løsninger på alt fra enkeltbarns behov for hjelp, til tilrettelegging for livslang læring og sosial utjevning. På den andre siden ser kartleggingsskeptikerne ut til å befinne seg innenfor den nordiske barnehagemodellen, som tradisjonelt bygger på et helhetlig syn på læring og på en sterk vektlegging av barndommens egenverdi. Spenningen kan ha store konsekvenser for praksisfeltet. I denne artikkelen drøfter jeg språkkartleggingsdiskursen i lys av teori om vitenskapelige kontroverser og konkluderer med at det er åpning for kompromisser, men også at det er tendenser i diskursen som snarere kan forsterke enn redusere uenigheten om språkkartlegging av flerspråklige barn i barnehagen. Mapping of language skills in early childhood education and care (ECEC institutions is controversial. On the one hand, there are those who support language mapping based on a belief that mapping and measuring can help language acquisition and facilitate lifelong learning and social integration. On the other hand, there are skeptics who oppose mapping and emphasize the values of childhood. This article discusses the discourses on language mapping in light of theories on scientific controversies. Based on the analysis I find that although there are openings for compromises, it seems that tendencies in the discourse may amplify rather than reduce the controversy on the language mapping of multilingual children in Norwegian ECEC institutions.

  1. A.V. Usova's Contribution to the Field of Concept Learning in Physics Classroom

    Science.gov (United States)

    Yavoruk, Oleg

    2015-01-01

    A.V. Usova (1921-2014) has always been one of the leading figures in Russian physics education. Her theory of physics concept formation was formulated during the 1970s and the 1980s and directly influenced the process of physics education in the 20th and the 21st century. Over the years there have been a lot of theories of concept formation. Her…

  2. Kjemiske og biokjemiske studier av den maliske medisinplanten Terminalia macroptera : Etnofarmakologiske studier i Mali

    OpenAIRE

    Pham, Anh Thu

    2009-01-01

    Blader fra den vest-afrikanske planten Terminalia macroptera ble ekstrahert suksessivt med diklormetan og metanol. Disse utgjorde råekstraktene, som var utgangspunkt for videre separasjon og fraksjonering ved hjelp av væske-væske ekstraksjon, kolonnekromatografi og tynnsjiktskromatografi. De isolerte forbindelsene ble strukturoppklart ved 1H-, 13C-, APT- og COSY NMR-spektroskopi. Shikimisyre, flavonoidglykosidene rutin og narcissin, og ellagitanninet corilagin ble isolert fra butanol-fasen...

  3. Med sjefen på Facebook: En studie av ledere som er "venner" med sine ansatte

    OpenAIRE

    Jensen, Anita

    2014-01-01

    MR690 Masteroppgave i organisasjon og ledelse - utdanningsledelse Formålet med studien er å belyse hvordan aktiv bruk av sosiale medier, i dette tilfellet Facebook, påvirker relasjoner mellom mennesker. Hva skjer når en tar i bruk en websjanger som i utgangspunktet er umiddelbar og uformell, til jobbrelatert og mer formell kommunikasjon? Er det sjangeren eller relasjonen som endres? Søkelyset rettes mot ledere som er “venner” med sine medarbeidere, og problemstillingen er...

  4. Performance comparison of AV1, HEVC, and JVET video codecs on 360 (spherical) video

    Science.gov (United States)

    Topiwala, Pankaj; Dai, Wei; Krishnan, Madhu; Abbas, Adeel; Doshi, Sandeep; Newman, David

    2017-09-01

    This paper compares the coding efficiency performance on 360 videos, of three software codecs: (a) AV1 video codec from the Alliance for Open Media (AOM); (b) the HEVC Reference Software HM; and (c) the JVET JEM Reference SW. Note that 360 video is especially challenging content, in that one codes full res globally, but typically looks locally (in a viewport), which magnifies errors. These are tested in two different projection formats ERP and RSP, to check consistency. Performance is tabulated for 1-pass encoding on two fronts: (1) objective performance based on end-to-end (E2E) metrics such as SPSNR-NN, and WS-PSNR, currently developed in the JVET committee; and (2) informal subjective assessment of static viewports. Constant quality encoding is performed with all the three codecs for an unbiased comparison of the core coding tools. Our general conclusion is that under constant quality coding, AV1 underperforms HEVC, which underperforms JVET. We also test with rate control, where AV1 currently underperforms the open source X265 HEVC codec. Objective and visual evidence is provided.

  5. Characterisation of human AV-nodal properties using a network model.

    Science.gov (United States)

    Wallman, Mikael; Sandberg, Frida

    2018-02-01

    Characterisation of the AV-node is an important step in determining the optimal form of treatment for supraventricular tachycardias. To integrate and analyse patient-specific measurements, mathematical modelling has emerged as a valuable tool. Here we present a model of the human AV-node, consisting of a series of interacting nodes, each with separate dynamics in refractory time and conduction delay. The model is evaluated in several scenarios, including atrial fibrillation (AF) and clinical pacing, using simulated and measured data. The model is able to replicate signals derived from clinical ECG data as well as from invasive measurements, both under AF and pacing. To quantify the uncertainty in parameter estimation, 1000 parameter sets were sampled, showing that model output similar to data corresponds to limited regions in the model parameter space. The model is the first human AV-node model to capture both spatial and temporal dynamics while being efficient enough to allow interactive use on clinical timescales, as well as parameter estimation and uncertainty quantification. As such, it fills a new niche in the current set of published models and forms a valuable tool for both understanding and clinical research.

  6. Las enfermedades infecciosas y su importancia en el sector avícola

    Directory of Open Access Journals (Sweden)

    Javier Andrés Jaimes Olaya

    2010-12-01

    Full Text Available Dentro del contexto de un país cuyas mejores capacidades se encuentran en el sector agropecuario, la industria avícola se ha convertido en uno de los sectores más promisorios y de mayor crecimiento en Colombia. Por esta razón, actualmente se vienen implementando programas para el mejoramiento de la calidad de los productos avícolas, con el objetivo no solo de mantener el crecimiento de la industria,sino de poder expandir las fronteras de exportación. Sin embargo, la avicultura enfrenta un gran reto encuanto a su producción, debido a que las enfermedades infecciosas que afectan a las aves continúan siendo una problemática importante del sector, aun por encima de la alimentación y la genética. En este artículo se presentan elementos de relevancia referentes a la industria avícola, así como en relación con las enfermedades de control oficial y algunas de las enfermedades infecciosas que más la aquejan, enfatizando en la importancia de la intervención en el manejo y control de dichas enfermedades.

  7. "Kven er det som skriv?" Skriveren i romanen Naustet av Jon Fosse

    Directory of Open Access Journals (Sweden)

    Natascha Reinhoff

    2002-08-01

    Full Text Available Når det gjelder romanen Naustet av Jon Fosse er det ikke tvil om at det blant annet – og kanskje hovedsaklig – er „dette noko / skrifta berettar om“. Det er derfor denne romanen også kan kalles for en metaroman. Tematiseringen av skriveren og skriveprosessen i romanen tar ikke bare mye plass på historienivå: Den gjennomsyrer romanen. Nært forbundet med denne tematikken er et fenomen jeg ville kalle for „dobbeltperspektivet i romanen“, og det er dette jeg vil se litt nærmere på her. Selv om romanen Naustet – i god postmoderne tradisjon – i siste – og kanskje allerede i første – instans unndrar seg en fast og entydig tilskrivning av betydning – og slik bevarer sin magi – skal jeg prøve å nærme meg skriveren og dobbeltperspektivet „eit stykke på veg“. Men først et par ord om begrepet skriver.

  8. Phase 1 Trial of Subcutaneous rAvPAL-PEG in Subjects with Phenylketonuria

    Science.gov (United States)

    Longo, Nicola; Harding, Cary O.; Burton, Barbara K.; Grange, Dorothy K.; Vockley, Jerry; Wasserstein, Melissa; Rice, Gregory M.; Musson, Donald G.; Gu, Zhonghua; Sile, Saba

    2014-01-01

    Objective Phenylketonuria is an inherited disease caused by impaired activity of phenylalanine hydroxylase, the enzyme that converts phenylalanine to tyrosine, leading to accumulation of phenylalanine and subsequent neurocognitive dysfunction. A phenylalanine-restricted diet initiated early in life can ameliorate the toxic effects of phenylalanine. However, the diet is onerous and compliance is extremely difficult. Phenylalanine ammonia lyase (PAL) is a prokaryotic enzyme that converts phenylalanine to ammonia and trans-cinnamic acid. This Phase 1, multicenter clinical trial evaluated the safety, tolerability, pharmacokinetics and efficacy of rAvPAL-PEG (recombinant Anabaena variabilis PAL produced in E. coli conjugated with polyethylene glycol [PEG] to reduce immunogenicity) in reducing phenylalanine levels in subjects with phenylketonuria. Methods Single subcutaneous injections of rAvPAL-PEG in escalating doses (0·001, 0·003, 0·01, 0·03, and 0·1 mg/kg) were administered to 25 adults with phenylketonuria recruited from those attending metabolic clinics in North America whose blood phenylalanine concentrations were ≥600 μmol/L. Results The most frequently reported adverse events were injection-site reactions and dizziness. Reactions were self-limited without sequelae. During the trial, two subjects had adverse reactions to intramuscular (IM) medroxyprogesterone acetate, a drug containing polyethylene glycol as an excipient. Three subjects developed a generalized skin rash at the highest rAvPAL-PEG dose (0·1 mg/kg). Drug levels peaked ∼5 days after the injection. Treatment was effective in reducing blood phenylalanine in all five subjects receiving the highest dose (0·1 mg/kg, mean percent change of -58 from baseline), with a nadir ∼6 days after injection and inverse correlation between drug and phenylalanine concentrations in plasma. Phenylalanine concentrations returned to near-baseline levels ∼20 days after the single injection. Conclusions

  9. Frequency-dependent electrophysiological remodeling of the AV node by hydroalcohol extract of Crocus sativus L. (saffron) during experimental atrial fibrillation: the role of endogenous nitric oxide.

    Science.gov (United States)

    Khori, Vahid; Alizadeh, Ali Mohammad; Yazdi, Hamidreza; Rakhshan, Elnaz; Mirabbasi, Abbas; Changizi, Shima; Mazandarani, Masumeh; Nayebpour, Mohsen

    2012-06-01

    The study assessed the hydroalcohol extract effects of Crocus sativus L. (saffron) on (i) the basic and rate-dependent electrophysiological properties of the AV node, (ii) remodeling of the AV node during experimental atrial fibrillation (AF) and (iii) the role of nitric oxide (NO) in the effects of saffron on the AV node. Stimulation protocols in isolated AV node were used to quantify AV nodal recovery, facilitation and fatigue in four groups of rabbits (n = 8-16 per group). In addition, the nodal response to AF was evaluated at multiple cycle lengths and during AF. Saffron had a depressant effect on AV nodal rate-dependent properties; further, it increased Wenckebach block cycle length, functional refractory period, facilitation and fatigue (p AV node (p AV node during AF by saffron. Saffron increased the AV nodal refractoriness and zone of concealment. These depressant effects of saffron were mediated by endogenous NO. Copyright © 2011 John Wiley & Sons, Ltd.

  10. Marknadsföring av Corporate Social Responsibility : En studie i Generation Y:s attityder till CSR samt attityder till marknadsföring av CSR inomsnabbmatsbranschen i Sverige

    OpenAIRE

    Pahkamaa, Tobias; Hamrin, Emil

    2012-01-01

    Denna uppsats undersöker konsumentgrupp Generation Y:s attityd till Corporate SocialResponsibility (CSR) samt marknadsföring av CSR. Vidare undersöks i uppsatsen Generation Y:sattityder till CSR samt marknadsföring av CSR gällande detaljister inom snabbmatsbranschen iSverige. Uppsatsens teoribildning baseras på teorier om attityder från framförallt Fishbein ochAjzen (1975), samt teorier om CSR och marknadsföring av CSR. Teorin knyts samman i enanalysmodell baserad på Wang och Andersons (2011)...

  11. Non-physiological increase of AV conduction time in sinus disease patients programmed in AAIR-based pacing mode.

    Science.gov (United States)

    Mabo, Philippe; Cebron, Jean-Pierre; Solnon, Aude; Tassin, Aude; Graindorge, Laurence; Gras, Daniel

    2012-11-01

    The EVOCAV(DS) trial aimed to quantify the paradoxal atrioventricular (AV) conduction time lengthening in sinus node (SD) patients (pts) paced in AAIR-based pacing mode. SD pts, implanted with dual-chamber pacemaker programmed in AAIR-based pacing mode, were randomized in two arms for a 1-month period: the low atrial pacing (LAP; basic rate at 60 bpm, dual sensor with minimal slope) and the high atrial pacing (HAP; basic rate at 70 bpm, dual sensor with optimized slope, overdrive pacing) arm. At 1 month, crossover was performed for an additional 1-month period. AV conduction time, AV block occurrence and AV conduction time adaptation during exercise were ascertained from device memories at each follow-up. Seventy-nine pts participated to the analysis (75 ± 8 years; 32 male; PR = 184 ± 38 ms; bundle branch block n = 12; AF history n = 36; antiarrhythmic treatment n = 53; beta-blockers n = 27; class III/Ic n = 18; both n = 8). The mean AV conduction time was significantly greater during the HAP (275 ± 51 ms) vs. LAP (263 ± 49 ms) period (p AV blocks occurred in 49 % of pts in the HAP vs. 19 % in the LAP period (p AV conduction time during exercise. AAIR-based pacing in SD pts may induce a significant lengthening of pts' AV conduction time, including frequent abnormal adaptation of AV conduction time during exercise.

  12. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue.

    Science.gov (United States)

    Marquié, Marta; Normandin, Marc D; Vanderburg, Charles R; Costantino, Isabel M; Bien, Elizabeth A; Rycyna, Lisa G; Klunk, William E; Mathis, Chester A; Ikonomovic, Milos D; Debnath, Manik L; Vasdev, Neil; Dickerson, Bradford C; Gomperts, Stephen N; Growdon, John H; Johnson, Keith A; Frosch, Matthew P; Hyman, Bradley T; Gómez-Isla, Teresa

    2015-11-01

    To examine region- and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau-containing lesions, and to determine whether there is off-target binding to other amyloid/non-amyloid proteins. We applied [F-18]-AV-1451 phosphor screen autoradiography, [F-18]-AV-1451 nuclear emulsion autoradiography, and [H-3]-AV-1451 in vitro binding assays to the study of postmortem samples from patients with a definite pathological diagnosis of Alzheimer disease, frontotemporal lobar degeneration-tau, frontotemporal lobar degeneration-transactive response DNA binding protein 43 (TDP-43), progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, multiple system atrophy, cerebral amyloid angiopathy and elderly controls free of pathology. Our data suggest that [F-18]-AV-1451 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer brains (eg, intraneuronal and extraneuronal tangles and dystrophic neurites), but does not seem to bind to a significant extent to neuronal and glial inclusions mainly composed of straight tau filaments in non-Alzheimer tauopathy brains or to lesions containing β-amyloid, α-synuclein, or TDP-43. [F-18]-AV-1451 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions was identified. Our data suggest that [F-18]-AV-1451 holds promise as a surrogate marker for the detection of brain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzheimer brains but also point to its relatively lower affinity for lesions primarily made of straight tau filaments in non-Alzheimer tauopathy cases and to the existence of some [F-18]-AV-1451 off-target binding. These findings provide important insights for interpreting in vivo patterns of [F-18]-AV-1451 retention

  13. The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.

    Science.gov (United States)

    Vermeiren, Céline; Motte, Philippe; Viot, Delphine; Mairet-Coello, Georges; Courade, Jean-Philippe; Citron, Martin; Mercier, Joël; Hannestad, Jonas; Gillard, Michel

    2018-02-01

    Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear palsy (PSP) is less clear as there is substantial overlap of signal in multiple brain regions. Moreover, accurate quantification of [ 18 F]AV-1451 uptake in Alzheimer's disease may not be possible. The aim of the present study was to characterize the in vitro binding of AV-1451 to understand and identify potential off-target binding that could explain the poor discrimination observed in PSP patients. [ 3 H]AV-1451 and AV-1451 were characterized in in vitro binding assays using recombinant and native proteins/tissues from postmortem samples of controls and Alzheimer's disease and PSP patients. [ 3 H]AV-1451 binds to multiple sites with nanomolar affinities in brain homogenates and to tau fibrils isolated from Alzheimer's disease or PSP patients. [ 3 H]AV-1451 also binds with similarly high affinities in brain homogenates devoid of tau pathology. This unexpected binding was demonstrated to be because of nanomolar affinities of [ 3 H]AV-1451 for monoamine oxidase A and B enzymes. High affinity of AV-1451 for monoamine oxidase proteins may limit its utility as a tau PET tracer in PSP and Alzheimer's disease because of high levels of monoamine oxidase expression in brain regions also affected by tau deposition, especially if monoamine oxidase levels change over time or with a treatment intervention. © 2017 International Parkinson and Movement Disorder Society. © 2017 International Parkinson and Movement Disorder Society.

  14. Multimodal correlation of dynamic [18F]-AV-1451 perfusion PET and neuronal hypometabolism in [18F]-FDG PET.

    Science.gov (United States)

    Hammes, Jochen; Leuwer, Isabel; Bischof, Gérard N; Drzezga, Alexander; van Eimeren, Thilo

    2017-12-01

    Cerebral glucose metabolism measured with [18F]-FDG PET is a well established marker of neuronal dysfunction in neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET is currently under evaluation and shows promising results. Here, we assess the feasibility of early perfusion imaging with AV-1451 as a substite for FDG PET in assessing neuronal injury. Twenty patients with suspected neurodegeneration underwent FDG and early phase AV-1451 PET imaging. Ten one-minute timeframes were acquired after application of 200 MBq AV-1451. FDG images were acquired on a different date according to clinical protocol. Early AV-1451 timeframes were coregistered to individual FDG-scans and spatially normalized. Voxel-wise intermodal correlations were calculated on within-subject level for every possible time window. The window with highest pooled correlation was considered optimal. Z-transformed deviation maps (ZMs) were created from both FDG and early AV-1451 images, comparing against FDG images of healthy controls. Regional patterns and extent of perfusion deficits were highly comparable to metabolic deficits. Best results were observed in a time window from 60 to 360 s (r = 0.86). Correlation strength ranged from r = 0.96 (subcortical gray matter) to 0.83 (frontal lobe) in regional analysis. ZMs of early AV-1451 and FDG images were highly similar. Perfusion imaging with AV-1451 is a valid biomarker for assessment of neuronal dysfunction in neurodegenerative diseases. Radiation exposure and complexity of the diagnostic workup could be reduced significantly by routine acquisition of early AV-1451 images, sparing additional FDG PET.

  15. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally.

    Science.gov (United States)

    Kyriacou, Andreas; Pabari, Punam A; Mayet, Jamil; Peters, Nicholas S; Davies, D Wyn; Lim, P Boon; Lefroy, David; Hughes, Alun D; Kanagaratnam, Prapa; Francis, Darrel P; Whinnett, Zachary I

    2014-02-01

    The mechanoenergetic effects of atrioventricular delay optimization during biventricular pacing ("cardiac resynchronization therapy", CRT) are unknown. Eleven patients with heart failure and left bundle branch block (LBBB) underwent invasive measurements of left ventricular (LV) developed pressure, aortic flow velocity-time-integral (VTI) and myocardial oxygen consumption (MVO2) at 4 pacing states: biventricular pacing (with VV 0 ms) at AVD 40 ms (AV-40), AVD 120 ms (AV-120, a common nominal AV delay), at their pre-identified individualised haemodynamic optimum (AV-Opt); and intrinsic conduction (LBBB). AV-120, relative to LBBB, increased LV developed pressure by a mean of 11(SEM 2)%, p=0.001, and aortic VTI by 11(SEM 3)%, p=0.002, but also increased MVO2 by 11(SEM 5)%, p=0.04. AV-Opt further increased LV developed pressure by a mean of 2(SEM 1)%, p=0.035 and aortic VTI by 4(SEM 1)%, p=0.017. MVO2 trended further up by 7(SEM 5)%, p=0.22. Mechanoenergetics at AV-40 were no different from LBBB. The 4 states lay on a straight line for Δexternal work (ΔLV developed pressure × Δaortic VTI) against ΔMVO2, with slope 1.80, significantly >1 (p=0.02). Biventricular pacing and atrioventricular delay optimization increased external cardiac work done but also myocardial oxygen consumption. Nevertheless, the increase in cardiac work was ~80% greater than the increase in oxygen consumption, signifying an improvement in cardiac mechanoenergetics. Finally, the incremental effect of optimization on external work was approximately one-third beyond that of nominal AV pacing, along the same favourable efficiency trajectory, suggesting that AV delay dominates the biventricular pacing effect - which may therefore not be mainly "resynchronization". © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

  16. Pastorer i trosbevegelsen : en studie av to norske pastorer sin autoritetsforståelse og rolleforståelse

    OpenAIRE

    Bryne, Jarle

    2007-01-01

    Masteroppgave i kristendomskunnskap - Universitetet i Agder 2007 Jeg har valgt bevisst et omfattende sammendrag. Sammendraget er utformet med tanke på at det skal være mulig for leseren å få et inntrykk av mine resultater i prosjektet uten at leseren trenger å lese hele prosjektet. Jeg har laget et sammendrag fra hvert kapittel. Kapittel 1: Prosjektet mitt handler om undersøkelser av to sentrale ledere i trosbevegelen. Henholdsvis Åge Åleskjær som er leder av Oslo Kristne Senter på Kjel...

  17. Lean Construction applicerat på betongkonstruktion : The Last Planner och visuell metodik för reducering av produktionstidsvariationer

    OpenAIRE

    Udroiu, Cristina

    2011-01-01

    Bakgrunden till detta examensarbete är byggföretagens utmaningar med att bedriva byggprojekt där nya och unika objekt skall konstrueras, med många nya förutsättningar och allt som oftast även en ny sammansättning av personalstyrkan. Ett gemensamt behov för dessa byggprojekt är att effektivt kunna hantera en mängd av olika och nya variationer. Oden anläggningsentreprenad AB presenterade ett problem gällande oönskade variationer av produktionstider för betongmonoliter som innefattar mycket repe...

  18. E-læring som pedagogisk virkemiddel for innlæring av anatomi, fysiologi og biokjemi i sykepleierutdanningen

    OpenAIRE

    Meyer, Mona Elisabeth

    2014-01-01

    Utgangspunktet for studien er at naturvitenskaplige fag, særlig anatomi, fysiologi og biokjemi (AFB), oppleves som vanskelig for sykepleierstudentene. Hensikten var å undersøke om læringsverktøyet e-læring, i form av nettester, kan være et effektivt virkemiddel til innlæring av og påvirke læringsutbyttet i AFB.Førsteårsstudentene i bachelorutdanningen i sykepleie ved Høgskolen i Akershus fikk et spørreskjema med 23 spørsmål som ble besvart anonymt.Resultatet av studentundersøkelsen viste at n...

  19. 3D-skanning og 3D-printing som metode for produksjon av prøvehylser til overekstremiteter

    OpenAIRE

    Gabrielsen, Kristine Falk

    2017-01-01

    Den tradisjonelle metoden å produsere prøvehylser til proteser på innebærer en gipsavstøpning av amputasjonsstumpen før oppvarmet, gjennomsiktig termoplast trekkes over gipsavstøpningen ved hjelp av vakuum. Prosessen tar lang tid og krever at pasienten besøker klinikken flere ganger før prøvehylsen er klar. Målet med oppgaven er å avdekke om 3D-skanning og 3D-printing kan lønne seg tids- og kostnadsmessig som metode for produksjon av prøvehylser til overekstremiteter, samtidig som det gir et ...

  20. Intervensjonsstudien "Forebyggelse av lårhalsbrudd". Metode og praktisk gjennomføring

    Directory of Open Access Journals (Sweden)

    Elisabeth Kvaavik

    2009-11-01

    Full Text Available  Bakgrunn  3 kan forebygge brudd blant sykehjemsbeboere. Her beskrivesmetoden og den praktiske gjennomføringen av studien.Metode  mg vitamin D daglig som 5 ml tran og kontrollgruppa fikk 5 ml tran der vitamin D var fjernet. Endepunktenevar lårhalsbrudd og alle ikke-vertebrale brudd. Et enkelt studieopplegg ble vektlagt. På bakgrunnav styrkeberegningen var målsetningen å inkludere ca. 2000 deltakere.Resultater  Konklusjon  The intervention study”Prevention of hip fractures”. Nor J Epidemiol 2000; 10 (1: 79-85.  Background  3 can prevent suchfractures. Here we present the method and the implementation of the study.Method  mg vitamin D daily in 5 ml cod liver oil for 2 years and the control group received 5 ml cod liver oilwithout vitamin D. The endpoints were hip fractures and all non-vertebral fractures. It was consideredimportant to use a trial that the nursing homes would find easy to implement. According to power calculationthe aim was to include about 2000 participants.Results  Conclusion  : The participation was lower than expected as recruiting nursing homes and nursing homeresidents posed considerable difficulty. However, the great majority of the ward staff at the participatingwards did not find the intervention demanding. A total of 1144 was included in the study.: A total of 1144 residents from 51 nursing homes (of 106 invited in Oslo, Lier and Bergen participated.The participation rate at the individual nursing home varied from 3 to 57%. The participants were85 years old and 3/4 were women. Mean calcium intake from cheese and milk was 450 mg/day, more than40% used a vitamin D supplement while only 3% used a calcium supplement. 1/3 of the participants completedthe 2 years intervention, about 1/3 finished the intervention before 2 years because of death and 1/3finished before 2 years of other causes. The great majority of the wards did not find the interventiondemanding.: A randomised, double

  1. Att vara förälder till barn med funktionsnedsättning : erfarenheter av stöd och av att vara professionell stödjare.

    OpenAIRE

    Lindblad, Britt-Marie

    2005-01-01

    Avhandlingens övergripande syfte är att tolka och beskriva innebörder av stöd, utifrån att vara förälder till barn med funktionsnedsättning och att vara professionella stödjare. Datainsamling har skett i form av berättande intervjuer med 39 föräldrar (23 mödrar och 16 fäder) och 9 professionella (7 kvinnor, 2 män) från olika verksamheter. Samtliga intervjuer har analyserats med hjälp av fenomenologisk hermeneutisk metod. Innebörder av att vara förälder till barn med funktionsnedsättning (stud...

  2. Brain uptake of a non-radioactive pseudo-carrier and its effect on the biodistribution of [(18)F]AV-133 in mouse brain.

    Science.gov (United States)

    Wu, Xianying; Zhou, Xue; Zhang, Shuxian; Zhang, Yan; Deng, Aifang; Han, Jie; Zhu, Lin; Kung, Hank F; Qiao, Jinping

    2015-07-01

    9-[(18)F]Fluoropropyl-(+)-dihydrotetrabenazine ([(18)F]AV-133) is a new PET imaging agent targeting vesicular monoamine transporter type II (VMAT2). To shorten the preparation of [(18)F]AV-133 and to make it more widely available, a simple and rapid purification method using solid-phase extraction (SPE) instead of high-pressure liquid chromatography (HPLC) was developed. The SPE method produced doses containing the non-radioactive pseudo-carrier 9-hydroxypropyl-(+)-dihydrotetrabenazine (AV-149). The objectives of this study were to evaluate the brain uptake of AV-149 by UPLC-MS/MS and its effect on the biodistribution of [(18)F]AV-133 in the brains of mice. The mice were injected with a bolus including [(18)F]AV-133 and different doses of AV-149. Brain tissue and blood samples were harvested. The effect of different amounts of AV-149 on [(18)F]AV-133 was evaluated by quantifying the brain distribution of radiolabelled tracer [(18)F]AV-133. The concentrations of AV-149 in the brain and plasma were analyzed using a UPLC-MS/MS method. The concentrations of AV-149 in the brain and plasma exhibited a good linear relationship with the doses. The receptor occupancy curve was fit, and the calculated ED50 value was 8.165mg/kg. The brain biodistribution and regional selectivity of [(18)F]AV-133 had no obvious differences at AV-149 doses lower than 0.1mg/kg. With increasing doses of AV-149, the brain biodistribution of [(18)F]AV-133 changed significantly. The results are important to further support that the improved radiolabelling procedure of [(18)F]AV-133 using an SPE method may be suitable for routine clinical application. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Catheter ablation of pediatric AV nodal reentrant tachycardia: results in small children.

    Science.gov (United States)

    Krause, Ulrich; Backhoff, David; Klehs, Sophia; Kriebel, Thomas; Paul, Thomas; Schneider, Heike E

    2015-11-01

    AV nodal reentrant tachycardia (AVNRT) is commonly encountered in pediatric patients. Definite treatment can be achieved by catheter ablation. The purpose of the study was to evaluate the efficacy and safety of AVNRT ablation focusing on children with a body weight ≤25 kg. Catheter ablation of AVNRT was attempted in 253 patients. Median age was 12.5 years; median body weight was 48.7 kg. 25 (9.9 %) children had a body weight ≤25 kg. Congenital heart disease was present in 6 patients (2.4 %). Procedural success was achieved in 98 % using radiofrequency, in 100 % using cryoenergy alone, and in 94 % using both energy sources. In patients with a body weight ≤25 kg, success was achieved in 96 %. In patients ≤25 kg, fluoroscopy and procedure duration did not differ from those >25 kg. The rate of major complications was significantly higher in the patients ≤25 kg (12 vs. 2.2 %, p = 0.04). Permanent AV block after RF ablation occurred in 2 patients with congenital heart disease and one infant with a body weight of 8.7 kg. Catheter ablation of AVNRT in children and adolescents was safe and effective. Infants and small children with a body weight ≤25 kg had a higher prevalence of serious complications. This should alert physicians in decision making toward catheter ablation in these patients. In patients with congenital heart disease and different anatomy of the cardiac conduction system, operators must be aware of an increased risk for AV block.

  4. Diskurzivna konstrukcija lokalnih živil rekoloniziranih držav kot "superživil"

    OpenAIRE

    Števanec, Renata

    2016-01-01

    Diplomsko delo sodi na področje kritičnih diskurzivnih študij. Uporabimo dialektično-relacijski model kritične diskurzivne analize, kakor ga je razvil Norman Fairclough, da prikažemo povezavo med neoliberalnim normativom osebne odgovornosti za zdravje in konstrukcijo »superživil«. V teoretičnem delu diplomske naloge predstavimo družbeni in ekonomsko-politični kontekst proizvodnje lokalnih živil rekoloniziranih držav, ki jih globalni trg promovira kot »superživila«, in izpostavimo povezav...

  5. "rand on klaasist ..." = "strondin er av glasi ..." : [luuletused] / T̤roddur Poulsen ; tlk. Arvo Alas

    Index Scriptorium Estoniae

    Poulsen, T̤roddur

    2004-01-01

    Sisu: "rand on klaasist ..." = "strondin er av glasi ..."; "vesi kannab endas ka nukrust ..." = "vatiņ ber eisini sorg ..."; "Nägin unes et olid ..." = "Droymdi at t{250} ..."; "Tulevik kuulub lihale ..." = "Visi̤nin er kjaet ..."; "Ma pole kirjutanud ..." = "Eg har ikki skriva̧ ..."; "Fäärid sinus. Fäärid minus. Fäärid sidrunis. Fäärid ..." = "Faeroyar Í t̆r. Faeroyar Í m̆r. Faeroyar Í citr̤nini. Faeroyar ... "; "Ma ei suuda kirjutada ..." = "Eg kan ikki skriva ..."

  6. Fiskeren som forsvant? En studie av avfolking, overbefolking og endringsprosesser i norsk fiskerinæring

    OpenAIRE

    Johnsen, Jahn Petter

    2003-01-01

    Hva er en fisker? Dette er det sentrale spørsmålet i denne avhandlinga. Spørsmålet er utgangspunkt for å utforske endringsprosesser i fiskerinæringa, både i fortida og i samtida. På bakgrunn av dette drøfter avhandlinga hvilke oppfatninger, forståelser og beskrivelser som til enhver tid benyttes til å definere hva fiskere er i ulike sammenhenger. Undersøkelsen starter i det som kan kalles rekrutteringsdiskursen i fiske, som nettopp handler om hva fiskere er og hvordan de skapes...

  7. Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech.

    Science.gov (United States)

    Utianski, Rene L; Whitwell, Jennifer L; Schwarz, Christopher G; Senjem, Matthew L; Tosakulwong, Nirubol; Duffy, Joseph R; Clark, Heather M; Machulda, Mary M; Petersen, Ronald C; Jack, Clifford R; Lowe, Val J; Josephs, Keith A

    2018-02-01

    Apraxia of speech is a motor speech disorder characterized by combinations of slow speaking rate, abnormal prosody, distorted sound substitutions, and trial-and-error articulatory movements. Apraxia of speech is due to abnormal planning and/or programming of speech production. It is referred to as primary progressive apraxia of speech (PPAOS) when it is the only symptom of a neurodegenerative condition. Past reports suggest an association of PPAOS with primary 4-repeat (4R) tau (e.g., progressive supranuclear palsy, corticobasal degeneration), rather than amyloid, pathology. The goal of the current study was to investigate the distribution of tau tracer uptake using [18F]AV-1451 positron emission tomography (PET) imaging in patients with PPAOS. Fourteen PPAOS patients underwent [18F]AV-1451 PET (tau-PET) imaging, [C11] Pittsburgh Compound B (PiB) PET and structural MRI and were matched 3:1 by age and sex to 42 cognitively normal controls. Tau-PET uptake was assessed at the region-of-interest (ROI) level and at the voxel-level. The PPAOS group (n = 14) showed increased tau-PET uptake in the precentral gyrus, supplementary motor area and Broca's area compared to controls. To examine whether tau deposition in Broca's area was related to the presence of aphasia, we examined a subgroup of the PPAOS patients who had predominant apraxia of speech, with concomitant aphasia (PPAOSa; n = 7). The PPAOSa patients showed tau-PET uptake in the same regions as the whole group. However, the remaining seven patients who did not have aphasia showed uptake only in superior premotor and precentral cortices, with no uptake observed in Broca's area. This cross-sectional study demonstrates that elevated tau tracer uptake is observed using [18F]AV-1451 in PPAOS. Further, it appears that [18F]AV-1451 is sensitive to the regional distribution of tau deposition in different stages of PPAOS, given the relationship between tau signal in Broca's area and the presence of aphasia. Copyright

  8. Complete A-V block: incidental or a part of cor triatriatum dexter.

    Science.gov (United States)

    Guler, Y; Akgun, T; Toprak, C; Guler, A; Esen, A M

    2014-05-01

    Cor triatriatum dexter (CTD) is an extremely rare cardiac anomaly in which the right atrium is divided into two distinct chambers by a membrane. The persistence of the right valve of sinus venosus results in a complete septation of the right atrium. This anomaly is frequently associated with other right-sided cardiac abnormalities. Its clinical manifestation and the need for intervention are determined by the number and the size of the fenestrations on the membrane, associated cardiac anomalies and arrhythmias. We describe a case of CTD in a patient with complete atrioventricular (A-V) block.

  9. Individuell variasjon i utskillelse av 6-sulfatoksymelatonin og døgnrytmetype analysert hos skiftarbeidere

    Directory of Open Access Journals (Sweden)

    Tore Tynes

    2009-10-01

    Full Text Available  SAMMENDRAGI denne studien har vi undersøkt om det finnes noen sammenheng mellom målte verdier av urinmetabolitten6-sulfatoxymelatonin (aMT6s tatt ut i porsjoner gjennom døgnet og selvrapportert døgnrytme hos engruppe norske skiftarbeidere. Studien omfatter 19 arbeidstakere ved to produksjonsenheter ved HydroPorsgrunn, magnesiumfabrikken og fullgjødselfabrikk 3. Etter å ha deltatt i en studie der urinprøver blesamlet inn, svarte de involverte senere på et spørreskjema om søvn og døgnrytme. Resultatene indikerer ategenrapporterte B-type mennesker har en tendens til høyere midlere timeutskillelse av aMT6s analysert pådøgnbasis første døgn med nattskift, og en signifikant høyere nattutskillelse (8 timer i et kontrolldøgnhjemme. I fremtidige studier av melatoninsekresjon og utskillelse av metabolitt i urin, kan det være avinteresse samtidig å samle inn spørreskjemabaserte opplysninger om døgnrytmetype og utfyllende opplysningerom søvn og søvnmønster i relasjon til eksponeringer som skiftarbeid og andre arbeidsmiljøfaktorersom kan ha effekt på hormonbalansen.Tynes T, Haugsdal B, Tønnessen A, Kleiven M. Individual variations in excretion of6-sulfatoxymelatonin in morning and evening type Norwegian shift workers.Nor J Epidemiol ENGLISH SUMMARYThe aim of this study was to evaluate whether there is an association between measured values of the urinemetabolite 6-sulfatoxymelatonin (aMT6s in samples collected at selected intervals and self-reported diurnalrhythm in a group of Norwegian shift workers. The study included 19 workers at two production unitsat Hydro Porsgrunn, the magnesium factory and fertiliser factory 3. After submitting the urine samplesused for the study, subjects filled in a questionnaire on sleep and diurnal rhythm at a later date. The resultsindicate that self-reported evening type subjects have a tendency towards a higher mean hourly aMT6ssecretionfirst day on night shift, and a significantly higher night

  10. Leken med modelleseren : en analyse av Kerstin Ekmans roman "Händelser vid vatten"

    OpenAIRE

    Minsås, Unni Wenche

    2001-01-01

    Mitt prosjekt har vært å undersøke hvordan ulike lesere teoretisk sett vil forholde seg til Kerstin Ekmans roman Händelser vid vatten. Til dette formål har jeg brukt Ecos semiotiske leserteori som et redskap, for mellom annet å vise hvilke elementer i tekstens strategi som skaper de ulike modelleserne, hvordan leserne virker inn på teksten, og hva slags betydning forfatteren har som del av teksten for disse lesertypene. Min påstand var i utgangspunktet at en naiv modelleser først og fre...

  11. Jämförelse av Vuokkoset varumärkets image och profil

    OpenAIRE

    Lindblad, Amanda

    2012-01-01

    Syftet med examensarbetet var att jämföra Vuokkoset produkternas profil och image, samt att utreda hur konsumenten upplever förpackningen. Uppdragsgivaren för arbetet var Delipap Oy, vars varumärke Vuokkoset intimhygienprodukterna är. Företaget hade aldrig tidigare undersökt förpackningarnas funktionalitet på konsumenter. Som teori har använts både elekroniska källor och böcker. Examensarbetet utfördes som en kvalitativ undersökning. Undersökningen gjordes med hjälp av individuella intervj...

  12. Seguimiento de la construcción de edificio 43 viviendas Av/ Juan XXIII Valencia

    OpenAIRE

    BURGOS ROMERO, LUIS

    2011-01-01

    Convenios con empresa. La obra prevé la construcción de un edificio de 41 viviendas VP + 2 viviendas libres, constando de 2 plantas sótano para uso de aparcamiento y trasteros, planta baja con local comercial, 8 plantas con 5 viviendas por planta y una planta ático con 3 viviendas. La obra está en su fase de estructura, habiéndose realizado las plantas de sótano. Burgos Romero, L. (2011). Seguimiento de la construcción de edificio 43 viviendas Av/ Juan XXIII Valencia. http://hdl.handle.net...

  13. Införandet av IAS 41 : Hur har kapitalfördelningen mellan intressenter i den norska laxodlingsbranschen utvecklats?

    OpenAIRE

    Dahlén, Jonas; Josefsson, Carl

    2013-01-01

    Införandet av IAS 41 medförde att redovisningsprinciperna för värderingen av ett företags biologiska tillgångar förändrades. Det finns forskning på hur införandet av IAS 41 påverkat olika aktörer inom skogsindustrin men lite är skrivet om dess påverkan på laxodlingsindustrin. Denna uppsats ämnar undersöka hur kapitalfördelningen till intressenter utvecklats sedan införandet av IAS 41. Studien fokuserar på intressenterna ägare och anställda. Vi har tillämpat en kvantitativ metod där vår empiri...

  14. "With great power comes great responsibility" : En studie av teknik och biologi i superhjältefilmer

    OpenAIRE

    Hjelm, Niklas; Karlsson, Tobias

    2009-01-01

    Vår tids syn på teknik ser vi tydliga spår av i dagens filmer, och kanske framförallt superhjältefilmer. Där använder sig både hjältar och skurkar av avancerad teknik i sin kamp mot varandra. Men även synen på biologi avspeglas i dessa filmer, och det mest intressanta är när dessa ställs mot varandra. Vi har jämfört två av vår tids största hjältar, en som använder sig av teknik och en som har biologiska krafter, för att se vilka likheter och skillnader som finns. Hjältarna det rör sig om är S...

  15. IceBridge LVIS POS/AV L1B Corrected Position and Attitude Data, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains georeferencing data from the Applanix 510 and 610 POS AV systems flown with the Land, Vegetation, and Ice Sensor (LVIS) over Greenland,...

  16. Jämnt Lärande : Ett illustrerat hjälpmedel till normkritisk granskning av läromedel

    OpenAIRE

    Denninger, Johan

    2017-01-01

    I detta examensarbete undersöks normbildande och reproducering av normer i samband med bilder i läromedel som används av modersmålslärare i Eskilstuna Kommun. Arbetet bygger på problematiken att stereotyper och reproducering av normer är vanligt förkommande i läromedlen samt att lärarnas brist på tid och möjlighet att granska läromedlen normkritiskt. Syftet med arbetet är att formge ett gestaltningsförslag till ett illustrerat hjälpmedel för normkritisk granskning av läromed...

  17. Exklusiva urmärken : en branschundersökning med avseende på positionering och val av urverk

    OpenAIRE

    Andersson, Peter

    2006-01-01

    Marknaden för armbandsur är stor, och den del av denna marknad som utgörs av exklusiva ur med högt pris tycks ha helt andra egenskaper än den för armbandsur i övrigt. Hur övertygas en konsument om att ett mekaniskt ur som avviker flera sekunder per dygn är att föredra framför ett elektroniskt som avviker några sekunder på ett år? Syftet med denna rapport är att ge en övergripande bild av marknaden för exklusiva ur och urverk, samt att analysera ett antal av de aktörer som finns på marknaden u...

  18. En socialpsykologisk analys av samkönat partnervåld ur ett makt- och normativitetsperspektiv

    OpenAIRE

    von Braun, Thérèse

    2009-01-01

    Uppsatsens syfte var att nå en större teoretisk förståelse av samkönat partnervåld, genom att analysera olika forskningsartiklars narrativa konstruktioner av våldet. De två frågeställningarna var: 1. Hur diskuterar forskningslitteraturen samkönat partnervåld med fokus på temana relationsdynamik, karaktär hos parterna, kön, genus och sexualitet samt betydelsen av social kontext? 2. Hur diskuterar forskningslitteraturen det professionella bemötandet av samkönat partnervåld? De 21 valda primärdo...

  19. Automated and connected vehicle (AV/CV) test bed to improve transit, bicycle, and pedestrian safety : technical report.

    Science.gov (United States)

    2017-02-01

    Crashes involving transit vehicles, bicyclists, and pedestrians are a concern in Texas, especially in urban areas. This research explored the potential of automated and connected vehicle (AV/CV) technology to reduce or eliminate these crashes. The pr...

  20. Landing Gear Stroke and Load Predictions for the AV-8B Aircraft and Three Ski Jump Ramp Profiles for the Italian Carrier Andrea Doria

    National Research Council Canada - National Science Library

    Imhof, Gregory

    2004-01-01

    .... The effort was funded through a 90-day contract to use the NAVAIR AV-8B simulation to assess the landing gear stroke and load characteristics of the AV-8B aircraft with three potential ski jump...

  1. [18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation.

    Science.gov (United States)

    Ali, F; Whitwell, J L; Martin, P R; Senjem, M L; Knopman, D S; Jack, C R; Lowe, V J; Petersen, R C; Boeve, B F; Josephs, K A

    2018-03-01

    Corticobasal syndrome (CBS) is a phenotypic manifestation of diverse pathologies, including Alzheimer's disease and 4-repeat tauopathies. Predicting pathology in CBS is unreliable and, hence, molecular neuroimaging may prove to be useful. The aim of this study was to assess regional patterns of uptake on [ 18 F] AV-1451 PET in CBS and determine whether patterns of uptake differ according to beta-amyloid deposition or differing clinical presentations. Fourteen patients meeting criteria for CBS underwent Pittsburgh Compound B (PiB) and [ 18 F] AV-1451 PET. Seven patients presented as CBS and seven presented with apraxia of speech (AOS) and later evolved into CBS. A global PiB summary was calculated and used to classify patients as PiB (-) or PiB (+). AV-1451 uptake was calculated in fourteen regions-of-interest, with values divided by uptake in cerebellar crus grey matter to generate standard uptake value ratios. AV-1451 uptake was considered elevated if it fell above the 95th percentile from a group of 476 cognitively unimpaired normal controls. Six of the 14 CBS patients (43%) were PiB (+), with three of these patients showing strikingly elevated AV-1451 uptake across many cortical regions. Of the eight PiB (-) patients, only those with AOS showed elevated AV-1451 uptake in supplementary motor area and precentral cortex compared to controls. No region of elevated AV-1451 uptake were observed in PiB (-) typical CBS patients without AOS. These results suggest that regional [ 18 F] AV-1451 is variable in CBS and depends on the presence of beta-amyloid as well as clinical presentation such as AOS. PiB (+) CBS does not necessarily reflect underlying Alzheimer's disease; however, the possibility some of these patients will evolve into Alzheimer's disease over time cannot be excluded.

  2. AV3V lesions attenuate the cardiovascular responses produced by blood-borne excitatory amino acid analogs

    Science.gov (United States)

    Whalen, E. J.; Beltz, T. G.; Lewis, S. J.; Johnson, A. K.

    1999-01-01

    Systemic injections of the excitatory amino acid (EAA) analogs, kainic acid (KA) and N-methyl-D-aspartate (NMDA), produce a pressor response in conscious rats that is caused by a centrally mediated activation of sympathetic drive and the release of arginine vasopressin (AVP). This study tested the hypothesis that the tissue surrounding the anteroventral part of the third ventricle (AV3V) plays a role in the expression of the pressor responses produced by systemically injected EAA analogs. Specifically, we examined whether prior electrolytic ablation of the AV3V region would affect the pressor responses to KA and NMDA (1 mg/kg iv) in conscious rats. The KA-induced pressor response was smaller in AV3V-lesioned than in sham-lesioned rats (11 +/- 2 vs. 29 +/- 2 mmHg; P response in sham-lesioned but not AV3V-lesioned rats (+27 +/- 3 vs. +1 +/- 2 mmHg; P response in ganglion-blocked sham-lesioned rats was abolished by a vasopressin V1-receptor antagonist. Similar results were obtained with NMDA. The pressor response to AVP (10 ng/kg iv) was slightly smaller in AV3V-lesioned than in sham-lesioned ganglion-blocked rats (45 +/- 3 vs. 57 +/- 4 mmHg; P responses to systemically injected EAA analogs are smaller in AV3V-lesioned rats. The EAA analogs may produce pressor responses by stimulation of EAA receptors in the AV3V region, or the AV3V region may play an important role in the expression of these responses.

  3. Analys av skillnader och likheter i EU-länders långsiktiga klimatstrategier

    OpenAIRE

    Hansson, Caroline

    2012-01-01

    De internationella klimatförhandlingarna handlar om att hitta lösningar för att stabilisera halten av växthusgaser i atmosfären och att uppnå tvågradersmålet. För att uppnå målet finns olika utsläppsmål att sträva mot. Ett är ett utsläppstak där varje land inte får släppa ut mer än 2 ton CO2-ekv/capita per år för att tvågradersmålet ska uppnås. Ett annat utsläppsmål är att minska de nationella utsläppen med en viss procentsats. EU:s del i minskningen ligger på 80-95 % till 2050. Som en del av...

  4. Online remote radiological monitoring during operation of Advance Vitrification System (AVS), Tarapur

    International Nuclear Information System (INIS)

    Deokar, U.V.; Kulkarni, V.V.; Mathew, P.; Khot, A.R.; Singh, K.K.; Kamlesh; Deshpande, M.D.; Kulkarni, Y.

    2010-01-01

    Advanced Vitrification System (AVS) is commissioned for vitrification of high level waste (HLW) by using Joule heated ceramic melter first time in India. The HLW is generated in fuel reprocessing plant. For radiological surveillance of plant, Health Physics Unit (HPU) had installed 37 Area Gamma Monitors (AGM), 7 Continuous Air Monitors (CAM) and all types of personal contamination monitors. Exposure control is a major concern in operating plant. Therefore in addition to installed monitors, we have developed online remote radiation monitoring system to minimize exposures to the surveyor and operator. This also helped in volume reduction of secondary waste. The reliability and accuracy of the online monitoring system is confirmed by calibrating the system by comparing TLD and DRD readings and by theoretical analysis. In addition some modifications were carried in HP instruments to make them user friendly. This paper summarizes different kinds of remote radiological monitoring systems installed for online monitoring of Melter off Gas (MOG) filter, Hood filter, three exhaust filter banks, annulus air sampling and over pack monitoring in AVS. Our online remote monitoring system has helped the plant management to plan in advance for replacement of these filters, which resulted in considerable saving of collective dose. (author)

  5. Sammenligning av to blodprøver fra samme person analysert ved to laboratorier

    Directory of Open Access Journals (Sweden)

    Aage Tverdal

    2009-10-01

    Full Text Available  INNLEDNINGEpidemiologiske undersøkelser av lipidnivået hosbefolkningen er helt avhengig av at analysemetodeneholder stabilt nivå over flere år. Dette er lettest å oppnåhvis man hele tiden benytter ett laboratorium, oghjerte-karundersøkelsene til Statens helseundersøkelserhar konsekvent benyttet Klinisk kjemisk avdeling,Ullevål sykehus. Ulike hensyn kan likevel tilsi at andrelaboratorier benyttes. Undersøkelsene til Universiteteti Tromsø som har har vært gjennomført fire ganger iperioden 1973-1995, har vært utført ved Kliniskkjemisk avdeling, Regionsykehuset i Tromsø. Helseundersøkelseni Nord-Trøndelag 1995-1997 harbenyttet Sentrallaboratoriet, Innherred sykehus. I dettearbeidet viser vi hvor store forskjellene blir hvisfeltlagene sender prøver fra samme person til ulikelaboratorier. Vi har undersøkt forskjellene mellomRegionsykehuset i Tromsø og Ullevål sykehus, ogmellom Innherred sykehus og Ullevål sykehus.

  6. Slow pathway modification in patients presenting with only two consecutive AV nodal echo beats.

    Science.gov (United States)

    Wegner, Felix K; Silvano, Maria; Bögeholz, Nils; Leitz, Patrick R; Frommeyer, Gerrit; Dechering, Dirk G; Zellerhoff, Stephan; Kochhäuser, Simon; Lange, Philipp S; Köbe, Julia; Wasmer, Kristina; Mönnig, Gerold; Eckardt, Lars; Pott, Christian

    2017-02-01

    Slow pathway modification (SPM) is the therapy of choice for AV-nodal reentry tachycardia (AVNRT). When AVNRT is not inducible, empirical ablation can be considered, however, the outcome in patients with two AV nodal echo beats (AVNEBs) is unknown. Out of a population of 3003 patients who underwent slow pathway modification at our institution between 1993 and 2013, we retrospectively included 32 patients with a history of symptomatic tachycardia, lack of paroxysmal supraventricular tachycardia (pSVT) inducibility but occurrence of two AVNEBs. pSVT documentation by electrocardiography (ECG) was present in 20 patients. The procedural endpoint was inducibility of less than two AVNEBs. This was reached in 31 (97%) patients. Long-term success was assessed by a telephone questionnaire (follow-up time 63±9 months). A total 94% of the patients benefited from the procedure (59% freedom from symptoms; 34% improvement in symptoms). Among those patients in whom ECG documentation was not present, 100% benefited (58% freedom from symptoms, 42% improvement). This is the first collective analysis of a group of patients presenting with symptoms of pSVT and inducibility of only two AVNEBs. Procedural success and clinical long-term follow-up were in the range of the reported success rates of slow pathway modification of inducible AVNRT, independent of whether ECG documentation was present. Thus, SPM is a safe and effective therapy in patients with two AVNEBs. Copyright © 2016. Published by Elsevier Ltd.

  7. Dual chamber pacing with optimal AV delay in congestive heart failure: a randomized study.

    Science.gov (United States)

    Capucci, A; Romano, S; Puglisi, A; Santini, M; Pagani, M; Cazzin, R; Zanuttini, D; Mangiameli, S; Moracchini, P V; Neri, R; De Ciuceis, P; Circo, A; Cavaglià, S; De Seta, F

    1999-07-01

    A prospective randomized trial was set up to evaluate contractile parameters and quality of life in patients with congestive heart failure. We describe the results from 38 patients in sinus rhythm and with chronic heart failure due to congestive cardiomyopathy, prospectively randomized to optimal medical therapy (Group 1, 19 patients) or optimal medical therapy plus dual chamber pacemaker programmed to optimal AV delay (Group 2, 19 patients). At a 6 month follow-up, 7/19 patients in Group 1 had died compared with 5/19 patients in Group 2. During follow-up, there were few significant changes in evaluated parameters except for mitral regurgitation time, which was prolonged in Group 1 and shortened in Group 2. The systolic left ventricular diameter shortened significantly only in Group 2. An energy and activity questionnaire showed that the effect of DDD pacing in the latter patient population was beneficial. From these results we may conclude that at the 6 month follow-up DDD pacing with echo-optimized AV interval programming can improve quality of life without affecting survival.

  8. Novel inter and intra prediction tools under consideration for the emerging AV1 video codec

    Science.gov (United States)

    Joshi, Urvang; Mukherjee, Debargha; Han, Jingning; Chen, Yue; Parker, Sarah; Su, Hui; Chiang, Angie; Xu, Yaowu; Liu, Zoe; Wang, Yunqing; Bankoski, Jim; Wang, Chen; Keyder, Emil

    2017-09-01

    Google started the WebM Project in 2010 to develop open source, royalty- free video codecs designed specifically for media on the Web. The second generation codec released by the WebM project, VP9, is currently served by YouTube, and enjoys billions of views per day. Realizing the need for even greater compression efficiency to cope with the growing demand for video on the web, the WebM team embarked on an ambitious project to develop a next edition codec AV1, in a consortium of major tech companies called the Alliance for Open Media, that achieves at least a generational improvement in coding efficiency over VP9. In this paper, we focus primarily on new tools in AV1 that improve the prediction of pixel blocks before transforms, quantization and entropy coding are invoked. Specifically, we describe tools and coding modes that improve intra, inter and combined inter-intra prediction. Results are presented on standard test sets.

  9. Tissue and cell tropism of Indian cassava mosaic virus (ICMV) and its AV2 (precoat) gene product

    International Nuclear Information System (INIS)

    Rothenstein, Dirk; Krenz, Bjoern; Selchow, Olaf; Jeske, Holger

    2007-01-01

    In order to establish defined viruses for challenging plants in resistance breeding programmes, Indian cassava mosaic virus (ICMV; family Geminiviridae) DNA clones were modified to monitor viral spread in plants by replacing the coat protein gene with the green fluorescent protein (GFP) reporter gene. Comparative in situ hybridization experiments showed that ICMV was restricted to the phloem in cassava and tobacco. GFP-tagged virus spread similarly, resulting in homogeneous fluorescence within nuclei and cytoplasm of infected cells. To analyze viral intercellular transport in further detail, GFP was fused to AV2, a protein that has been implicated in viral movement. Expressed from replicating viruses or from plasmids, AV2:GFP became associated with the cell periphery in punctate spots, formed cytoplasmic as well as nuclear inclusion bodies, the latter as conspicuous paired globules. Upon particle bombardment of expression plasmids, AV2:GFP was transported into neighboring cells of epidermal tissues showing that the intercellular transport of the AV2 protein is not restricted to the phloem. The results are consistent with a redundant function of ICMV AV2 acting as a movement protein, presumably as an evolutionary relic of a monopartite geminivirus that may still increase virus fitness but is no longer necessary in a bipartite genome. The fusion of ICMV ORF AV2 to the GFP gene is the first example of a reporter construct that follows the whole track of viral DNA from inside the nucleus to the cell periphery and to the next cell

  10. Characterization of the cryptic AV3 promoter of ageratum yellow vein virus in prokaryotic and eukaryotic systems.

    Science.gov (United States)

    Wang, Wei-Chen; Wu, Chia-Ying; Lai, Yi-Chin; Lin, Na-Sheng; Hsu, Yau-Heiu; Hu, Chung-Chi

    2014-01-01

    A cryptic prokaryotic promoter, designated AV3 promoter, has been previously identified in certain begomovirus genus, including ageratum yellow vein virus isolate NT (AYVV-NT). In this study, we demonstrated that the core nucleotides in the putative -10 and -35 boxes are necessary but not sufficient for promoter activity in Escherichia coli, and showed that AYVV-NT AV3 promoter could specifically interact with single-stranded DNA-binding protein and sigma 70 of E. coli involved in transcription. Several AYVV-NT-encoded proteins were found to increase the activity of AV3 promoter. The transcription start sites downstream to AV3 promoter were mapped to nucleotide positions 803 or 805 in E. coli, and 856 in Nicotiana benthamiana. The eukaryotic activity of AV3 promoter and the translatability of a short downstream open reading frame were further confirmed by using a green fluorescent protein reporter construct in yeast (Saccharomyces cerevisiae) cells. These results suggested that AV3 promoter might be a remnant of evolution that retained cryptic activity at present.

  11. Development of an Advanced Aidman Vision Screener (AVS) for selective assessment of outer and inner laser induced retinal injury

    Science.gov (United States)

    Boye, Michael W.; Zwick, Harry; Stuck, Bruce E.; Edsall, Peter R.; Akers, Andre

    2007-02-01

    The need for tools that can assist in evaluating visual function is an essential and a growing requirement as lasers on the modern battlefield mature and proliferate. The requirement for rapid and sensitive vision assessment under field conditions produced the USAMRD Aidman Vision Screener (AVS), designed to be used as a field diagnostic tool for assessing laser induced retinal damage. In this paper, we describe additions to the AVS designed to provide a more sensitive assessment of laser induced retinal dysfunction. The AVS incorporates spectral LogMar Acuity targets without and with neural opponent chromatic backgrounds. Thus, it provides the capability of detecting selective photoreceptor damage and its functional consequences at the level of both the outer and inner retina. Modifications to the original achromatic AVS have been implemented to detect selective cone system dysfunction by providing LogMar acuity Landolt rings associated with the peak spectral absorption regions of the S (short), M (middle), and L (long) wavelength cone photoreceptor systems. Evaluation of inner retinal dysfunction associated with selective outer cone damage employs LogMar spectral acuity charts with backgrounds that are neurally opponent. Thus, the AVS provides the capability to assess the effect of selective cone dysfunction on the normal neural balance at the level of the inner retinal interactions. Test and opponent background spectra have been optimized by using color space metrics. A minimal number of three AVS evaluations will be utilized to provide an estimate of false alarm level.

  12. Off-Target18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation.

    Science.gov (United States)

    Choi, Jae Yong; Cho, Hanna; Ahn, Sung Jun; Lee, Jae Hoon; Ryu, Young Hoon; Lee, Myung Sik; Lyoo, Chul Hyoung

    2018-01-01

    Off-target binding in the basal ganglia is commonly observed in the 18 F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R 2 * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18 F-AV-1451 PET and R 2 * MRI studies. A correlation analysis was performed for age, 18 F-AV-1451 binding, and R 2 * values. Results: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Conclusion: Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

  13. Tissue and cell tropism of Indian cassava mosaic virus (ICMV) and its AV2 (precoat) gene product.

    Science.gov (United States)

    Rothenstein, Dirk; Krenz, Björn; Selchow, Olaf; Jeske, Holger

    2007-03-01

    In order to establish defined viruses for challenging plants in resistance breeding programmes, Indian cassava mosaic virus (ICMV; family Geminiviridae) DNA clones were modified to monitor viral spread in plants by replacing the coat protein gene with the green fluorescent protein (GFP) reporter gene. Comparative in situ hybridization experiments showed that ICMV was restricted to the phloem in cassava and tobacco. GFP-tagged virus spread similarly, resulting in homogeneous fluorescence within nuclei and cytoplasm of infected cells. To analyze viral intercellular transport in further detail, GFP was fused to AV2, a protein that has been implicated in viral movement. Expressed from replicating viruses or from plasmids, AV2:GFP became associated with the cell periphery in punctate spots, formed cytoplasmic as well as nuclear inclusion bodies, the latter as conspicuous paired globules. Upon particle bombardment of expression plasmids, AV2:GFP was transported into neighboring cells of epidermal tissues showing that the intercellular transport of the AV2 protein is not restricted to the phloem. The results are consistent with a redundant function of ICMV AV2 acting as a movement protein, presumably as an evolutionary relic of a monopartite geminivirus that may still increase virus fitness but is no longer necessary in a bipartite genome. The fusion of ICMV ORF AV2 to the GFP gene is the first example of a reporter construct that follows the whole track of viral DNA from inside the nucleus to the cell periphery and to the next cell.

  14. Magnetic-guided catheter ablation of twin AV nodal reentrant tachycardia in a patient with left atrial isomerism, interrupted inferior vena cana, and Kawashima-Fontan procedure.

    Science.gov (United States)

    Bessière, Francis; Mongeon, François-Pierre; Therrien, Judith; Khairy, Paul

    2017-12-01

    Twin AV nodal reentrant tachycardia most commonly occurs in patients with complex congenital heart disease who have two distinct AV nodes, His bundles, and non-preexcited QRS morphologies. Catheter ablation of the weaker AV node may be hindered by anatomical complexities. In such cases, remote magnetic guidance offers a potentially effective solution.

  15. DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine.

    Science.gov (United States)

    Buraka, E; Chen, C Yu-Chian; Gavare, M; Grube, M; Makarenkova, G; Nikolajeva, V; Bisenieks, I; Brūvere, I; Bisenieks, E; Duburs, G; Sjakste, N

    2014-09-05

    The ability to intercalate between DNA strands determines the cytotoxic activity of numerous anticancer drugs. Strikingly, intercalating activity was also reported for some compounds considered to be antimutagenic. The aim of this study was to determine the mode of interaction of DNA with the antimutagenic and DNA repair-stimulating dihydropyridine (DHP) AV-153. DNA and AV-153 interactions were studied by means of UV/VIS spectroscopy, fluorimetry and infrared spectroscopy. Compound AV-153 is a 1,4 dihydropyridine with ethoxycarbonyl groups in positions 3 and 5. Computer modeling of AV-153 and DNA interactions suggested an ability of the compound to dock between DNA strands at a single strand break site in the vicinity of two pyrimidines, which was confirmed in the present study. AV-153 evidently interacted with DNA, as addition of DNA to AV-153 solutions resulted in pronounced hyperchromic and bathochromic effects on the spectra. Base modification in a plasmid by peroxynitrite only minimally changed binding affinity of the compound; however, induction of single-strand breaks using Fenton's reaction greatly increased binding affinity. The affinity did not change when the ionic strength of the solution was changed from 5 to 150 mM NaCl, although it increased somewhat at 300 mM. Neither was it influenced by temperature changes from 25 to 40°C, however, it decreased when the pH of the solution was changed from 7.4 to 4.7. AV-153 competed with EBr for intercalation sites in DNA: 116 mM of the compound caused a two-fold decrease in fluorescence intensity. FT-IR spectral data analyses indicated formation of complexes between DNA and AV-153. The second derivative spectra analyses indicated interaction of AV-153 with guanine, cytosine and thymine bases, but no interaction with adenine was detected. The antimutagenic substance AV-153 appears to intercalate between the DNA strands at the site of a DNA nick in the vicinity of two pyrimidines. Copyright © 2014 Elsevier

  16. Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy.

    Science.gov (United States)

    Whitwell, Jennifer L; Ahlskog, J Eric; Tosakulwong, Nirubol; Senjem, Matthew L; Spychalla, Anthony J; Petersen, Ronald C; Jack, Clifford R; Lowe, Val J; Josephs, Keith A

    2018-03-01

    Little is known about Alzheimer's disease molecular proteins, beta-amyloid and paired helical filament (PHF) tau, in progressive supranuclear palsy (PSP). Recent techniques have been developed to allow for investigations of these proteins in PSP. We determined the frequency of beta-amyloid deposition in PSP, and whether beta-amyloid deposition in PSP is associated with PHF-tau deposition pattern, or clinical features. Thirty probable PSP participants underwent MRI, [ 18 F]AV-1451 PET and Pittsburgh compound B (PiB) PET. Apolipoprotein (APOE) genotyping was also performed. A global PiB standard-uptake value ratio (SUVR) was calculated. AV-1451 SUVRs were calculated for a set of Alzheimer's disease (AD)-related regions and a set of PSP-related regions. Voxel-level analyses were conducted to assess for differences in AV-1451 uptake patterns and MRI atrophy between PiB(+) and PiB(-) cases compared to 60 normal PiB(-) controls. Statistical testing for correlations and associations between variables of interest were also performed. Twelve subjects (40%) showed beta-amyloid deposition. Higher PiB SUVR correlated with older age but not with AV-1451 SUVR in the AD- or PSP-related regions. Higher AV-1451 SUVR in AD-related regions was associated with higher AV-1451 SUVR in PSP-related regions. We found little evidence for beta-amyloid related differences in clinical metrics, proportion of APOE e4 carriers, pattern of AV-1451 uptake, or pattern of atrophy. Beta-amyloid deposition occurs in a relatively high proportion of PSP subjects. Unlike in Alzheimer's disease, however, there is little evidence that beta-amyloid, and PHF-tau, play a significant role in neurodegeneration in PSP. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Mindfulness for militære veteraner som lider av PTSD

    OpenAIRE

    Aasvik, Erlend Winther; Amdal, Lilli

    2014-01-01

    Bakgrunn: Veteraner står i fare for å få Posttraumatisk stresslidelse (PTSD) ved gjentatte eksponeringer for traumer. I de senere år har det i Norge vært stadig fokus på veteraner som har fått slik lidelse men som ikke har fått oppfølgningen som de kanskje burde hatt. Mindfulness har også blitt veldig populært og er nå ofte å se i ukeblader, bokhandler og i medisinske blader. Hensikten: Vi ønsket å se om mindfulness kunne være et mulig hjelpemiddel for sykepleiere i behandling av veteraner...

  18. Bør man tillate at norske statsborgere benytter seg av surrogati i India?

    Directory of Open Access Journals (Sweden)

    Annelin Haukeland

    2013-11-01

    Full Text Available I Norge er ikke surrogati tillatt, og myndighetene fraråder norske statsborgere å benytte seg av surrogati i utlandet. I denne artikkelen fokuserer vi på kommersiell gestational surrogati og stiller spørsmålet: Bør man tillate at norske statsborgere benytter seg av surrogati i India? De etiske problemstillingene rundt surrogati er mange og sammensatte og blir spesielt utfordrende når tjenesten tilbys i et land med store kulturelle og økonomiske forskjeller både internt og i forhold til Norge. Vi baserer analysen og drøftingen av dette etisk utfordrende spørsmålet på Beauchamps og Childress sin veletablerte metodiske tilnærming innen biomedisinsk etikk. Vi anvender de fire allmennmoralske prinsipper: respekt for autonomi, velgjørenhet, ikke-skade og rettferdighet på sakskomplekset for å synliggjøre spenningene involvert i dette etiske dilemmaet. Med full bevissthet om at det ikke finnes noen lettvinte og omkostningsfrie løsninger på dilemmaer generelt og dette spesielt, konkluderer vi med at interessene til de berørte parter, og spesielt surrogatmødrenes, kan bli bedre ivaretatt om surrogati tillates under omfattende reguleringer. Dersom man velger å gjøre praksisen illegal, vil man også miste mulighetene til å påvirke prosessen og sikre rettighetene til de involverte partene.Nøkkelord: surrogati, Norge–India, utnyttelse, autonomi, regulering av prosessenEnglish summary: Should Norwegian citizens be permitted to use surrogacy in India?Surrogacy is not permitted in Norway, and the government strongly advises against Norwegian citizens travelling abroad to have children through the use of the surrogacy industry. In this article, we focus on commercial gestational surrogacy and debate the question: Should Norwegian citizens be permitted to use surrogacy in India? The ethical concerns regarding surrogacy are complex and are especially challenging when the service is offered in a country with big cultural and economic

  19. Skattetillägg i internprissättningsprocesser : En studie av begreppet oriktig uppgift

    OpenAIRE

    Baaz, Christoffer; Wahlbeck, Cesar

    2009-01-01

    Av globaliseringen följer en ökad handel mellan stater och inom multinationella koncer-ner där så kallade internprissättning sker. Genom internprissättningen ser företagen en möjlighet att överföra vinster till lågbeskattade länder. För att förhindra detta har regler som ska se till att marknadsmässiga villkor styr prissättningen upprättats. De svenska bestämmelserna för internprissättning utgår från korrigeringsregeln i 14 kap. 19 IL som ger uttryck för armlängdsprincipen. Principen innebär ...

  20. Magnetic excitations in low-dimensional spin systems: neutron scattering study on AV2O5

    International Nuclear Information System (INIS)

    Nakajima, Kenji

    1997-01-01

    Recent experiments on vanadium oxide bronzes AV 2 O 5 (A=Na, Mg, Li) are reviewed. Experiments are carried out combining two triple-axis spectrometers installed at a thermal beam port and a cold neutron guide at JRR-3M. Spin-wave excitations in single crystals NaV 2 O 5 in the spin-Peierls state shows a steep intra-chain dispersion, which is consistent with estimated exchange interaction from magnetization measurement, and a weak inter-chain dispersion. In the low energy excitation measurement on powder sample of MgV 2 O 5 , we have observed energy gap of 2 meV, which indicates that this material is a ladder system with strong 1D character. Preliminary result on LiV 2 O 5 , which is expected to be a simple 1D antiferromagnet or a zig-zag chain, is also mentioned

  1. Influencer marketing : En analys av en marknadsrättslig gråzon

    OpenAIRE

    Haglund Holst, Maximilian; Jorikson, Ludvig

    2017-01-01

    Uppsatsen kommer att behandla den relativt nya marknadsföringsmetoden influencer marketing. Influencer marketing innebär att en person å en näringsidkares vägnar marknadsför en viss produkt på sina sociala medier, till exempel en blogg. Denna metod har på senare tid vuxit och blivit ett framgångsrecept för många näringsidkare då de, med hjälp av influencern, kan nå ut direkt till en önskad målgrupp. I och med att Influencer marketing är en ny marknadsföringsmetod, innebär det att stor oklarhe...

  2. Transformering av kunnskap mellom campus og skole i lærerutdanningen

    Directory of Open Access Journals (Sweden)

    Britt Oda Fosse

    2016-04-01

    Full Text Available Til tross for lærerutdanningers mangeårige arbeid med å finne innovative løsninger som skaper gode sammenhenger mellom campuskonteksten og skolekonteksten, etterlyser lærerstudentene fortsatt en bedre sammenheng i studiet. Det som kjennetegner metodene i mange lærerutdanninger er at de bygger på ideen om læring for praksis. Dette innebærer i stor grad forventninger om at studentene transformerer kunnskap fra campus til undervisning og refleksjon i skolen. Mye tyder på at lærerstudentene får lite hjelp i denne prosessen. Studier om koherens – eller sammenheng – i lærerutdanningen knyttes sjelden til at lærerutdanning kan innebære et læringsproblem. Hensikten med denne artikkelen er å undersøke de læringsutfordringer studenter har når kunnskap skal transformeres mellom de to kontekstene. Tanken er at en forståelse for lærerstudenters læring på denne måten kan bidra inn i arbeidet med å videreutvikle metoder i lærerutdanningen som kan lette transformeringsprosessene. Artikkelen er tematisk og drøftes i lys av sosiokulturelle perspektiver på læring og utvikling med vekt på begrepene “overføring” og “transformering”. Videre drøftes problemstillingen i lys av studier av lærerstudenters interaktive læringsprosesser. Nøkkelord: lærerutdanning, lærerstudenters læringsprosesser, transformering av læring.AbstractDespite innovative work on bridging the gap between campus activities and classroom activities, student teachers ask for more coherence in their education. What characterizes the different teacher education innovations is that they are mainly based on the idea that students construct knowledge for practice. In these scenarios, teacher education programmes rely on the students’ ability to transform knowledge from activities at campus into teaching and reflection in their practice schools. The student teachers seem to get little or no help in these transformational processes. When studying

  3. Förvärmning av tilluften med återvunnen värme

    OpenAIRE

    Kader, Aza; Yousif, Peter

    2017-01-01

    Idag är det vanligt för fjärrvärmebolagen att basera sin taxa på effektbehovet för fastigheten. Effekttaxeringsmetod skiljer sig mellan olika fjärrvärmeleverantörer. Dock är toppeffektbehoven för fastigheterna en gemensam nämnare för bolagen när debiteringsunderlag beslutas.I Sverige finns det idag befintlig teknik som sänker effektbehovet genom förvärmning av uteluft, vilket reducerar frostbildning i värmeväxlaren och förbättras dess verkningsgrad. Denna teknik utnyttjar geoenergi som värmek...

  4. Introduction to COFFE: The Next-Generation HPCMP CREATE-AV CFD Solver

    Science.gov (United States)

    Glasby, Ryan S.; Erwin, J. Taylor; Stefanski, Douglas L.; Allmaras, Steven R.; Galbraith, Marshall C.; Anderson, W. Kyle; Nichols, Robert H.

    2016-01-01

    HPCMP CREATE-AV Conservative Field Finite Element (COFFE) is a modular, extensible, robust numerical solver for the Navier-Stokes equations that invokes modularity and extensibility from its first principles. COFFE implores a flexible, class-based hierarchy that provides a modular approach consisting of discretization, physics, parallelization, and linear algebra components. These components are developed with modern software engineering principles to ensure ease of uptake from a user's or developer's perspective. The Streamwise Upwind/Petrov-Galerkin (SU/PG) method is utilized to discretize the compressible Reynolds-Averaged Navier-Stokes (RANS) equations tightly coupled with a variety of turbulence models. The mathematics and the philosophy of the methodology that makes up COFFE are presented.

  5. Erfarenheter av portfoliometodiken inom nätutbildning – Kritiska reflektioner och ”halleluja moments”

    Directory of Open Access Journals (Sweden)

    Elinor Adenling

    2011-06-01

    Full Text Available Vid Pedagogiska institutionen vid Umeå universitet har nätutbildningen expanderat kraftigt under de senaste två och ett halvt åren, då institutionen började ge fristående helfartskurser i pedagogik via Internet. Vårterminen 2008 läste cirka 60 studenter och inför varje termin har sedan studenttillströmningen ökat, för att under våren 2010 uppgå till 240 studenter. Hösten 2008 infördes, med stöd av interna utvecklingsmedel, examinerande portfoliouppgifter på samtliga nätbaserade kurser med målsättningen att möta de utmaningar som både formen (nätundervisning och den utökade och heterogena studentgruppen innebar. Syftet var att stärka studenternas förmåga att synliggöra sitt eget lärande, samt att minska anonymiteten mellan lärare och student. Uppgifterna var av självreflekterande karaktär där studenterna uppmanades att relatera det egna lärandet till kursinnehållet och att exempelvis identifiera framtida tillämpningsområden inom studier och arbetsliv. Studenterna fick under terminen individuell återkoppling av en och samma lärare. Intentionen med återkopplingen var bland annat att guida och uppmuntra studenterna till att inta ett personligt förhållningssätt till kursinnehållet. I artikeln argumenteras det för att portfoliometodik i flera avseenden kan sägas harmoniera väl med ett rådande synsätt på examination där ett sociokulturellt synsätt på lärande dominerar och livslångt lärande och självständighet framhålls som eftersträvansvärt. Detta medför att, det både utifrån ett student- och ett lärarperspektiv, kan kännas naturlig och relevant att använda portfolio som examinationsform inom nätutbildning. Samtidigt är det viktigt att problematisera och kritiskt reflektera över portfoliometodik som examinationsform och de förhållningssätt och ideal som skapas, vilket görs i artikeln med hjälp av en Foucaultinspirerad tolkningsram. I artikeln presenteras alltså både ett

  6. En teoretisk utdyping av rom og materialitet som pedagogisk ressurs i barnehagen

    Directory of Open Access Journals (Sweden)

    Solveig Nordtømme

    2015-07-01

    Full Text Available Abstract: This article is a theoretical exploration with the aim of discussing an ontological basis for space and materiality as educational resources in kindergarten. Attention is directed on children’s play experiences interacting with space and materiality, and how children use and create space. The metaphors front stage, space in between, and backstage (inspired from Erving Goffman, 1969, which form the study's main findings, are used as the backdrop for the issue and analyzes. The empirical material used in this exploration has been collected with an ethnographic methodological approach in two kindergartens. Maurice Merleau-Ponty’s (1962 focus on bodily experience and presence in space, along with concepts from Latour’s (2005 actor-network theory, is used to explore the data. The article contributes with theoretical tools for professionals in kindergarten teaching, to shed light on the importance of space, materiality and play in children's everyday life in kindergarten.Sammendrag: Denne artikkelen diskuterer et ontologisk grunnlag og er en teoretisk utforskning av rom og materialitet som en pedagogisk ressurs i barnehagen. Oppmerksomheten er rettet mot barns lekeerfaringer i samspill med rom og materialitet, og hvordan barn bruker og skaper rom. Metaforene hovedrom, mellomrom, og bakrom (inspirert fra Erving Goffman, 1969, som danner studiens hovedfunn, blir brukt som et bakteppe for problemstilling og analyser av det empiriske materialet fra to barnehager. Maurice Merleau-Ponty publikasjoner The Phenomenology of Perception (Merleau-Ponty, 1962 med sitt fokus på kroppslig erfaring i levd rom, blir brukt sammen med begreper fra Latours aktør-nettverksteori (Latour 2005 til å utforske hvordan rom og materialitet kan være pedagogiske ressurser. Artikkelens kunnskapsbidrag er å presentere et teoretisk verktøy for barnehageprofesjonen og kunnskaper om lekens betydning i barns hverdag i barnehagen.

  7. Dia dos Avós: atividades socioeducativas e intergeracionais bem-sucedidas

    Directory of Open Access Journals (Sweden)

    Flávia Renata Fratezi

    2013-10-01

    Full Text Available O Dia da Avó é comemorado em 26 de julho, uma data estratégica para estimular a interação social entre diferentes gerações e reflexões acerca do envelhecimento humano e da velhice. Em face dos potenciais benefícios das intervenções intergeracionais e socioeducativas, o objetivo deste artigo é apresentar um relato de experiência sobre as atividades realizadas durante um evento no Dia da Avó. Esse evento ocorreu em um parque público do município de São Paulo no ano de 2009 e contou com a participação de 350 idosos e 60 crianças. Durante as intervenções houve a divulgação de informações sobre como tornar o envelhecimento um processo orientado e bem assistido, o que favoreceu a reflexão de estratégias pessoais, sociais e coletivas para a participação social e a promoção da saúde ao longo do curso de vida, integrando diferentes gerações. Uma sociedade preparada para a temática da velhice e dos temas associados ao ciclo vital humano inicia a discussão desses temas nas comunidades, perpetuando a reflexão de maneira coletiva e com a participação de variados atores sociais. O bacharel em gerontologia, novo profissional na área do envelhecimento no Brasil, têm competências para favorecer, promover e integrar intervenções intergeracionais e socioeducativas que visam ao envelhecimento ativo.

  8. A.V. CHAYANOV ON THE WAY TO THE THEORY OF NON-CAPITALIST ECONOMY

    Directory of Open Access Journals (Sweden)

    А А Крамар

    2018-12-01

    Full Text Available Alexander V. Chayanov (1888-1937 is a famous Russian economist, theorist of the organization of economy, a brilliant representative of the generation of the “golden age” of the economic science in Russia. One of the key elements of his scientific legacy is the theory of non-capitalist forms of economy, and one of its aspects - international agrarian studies of the features of the organization of agriculture in different countries. The organizational-production school developed a theory of labor economy and came close to the general theory of non-capitalist forms of economy; however, its studies were inter-rupted by the repressions of the 1920s. The article considers the international studies of A.V. Chayanov to clarify and develop some findings of the today’s scholars (I.A. Kuznetsov, A.M. Nikulin, T.A. Savinova. The author proposes a new interpretation of the organizational-production school as having a dualistic character. The works of Alexander N. Chelintsev (1874-1962, Nicholay P. Makarov (1886-1980 and other colleagues of A.V. Chayanov from the organizational-production school focused on both theoretical issues such as the fundamental laws of functioning and development of agriculture, and practical issues of scientific management of an individual farm and agriculture in general. The author considers the orga-nizational-production school as dualistic: it studies both theory and management of peasant economy at micro- and macro-levels proceeding from the analysis of the individual farm structure to the issues of the optimal production location and optimal management of ‘a mass of peasant farms’. The system approach to the organization of economy, cooperation, zoning and economic policy developed by the organizational-production school is still relevant for the contemporary use.

  9. 18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy

    Science.gov (United States)

    Passamonti, Luca; Vázquez Rodríguez, Patricia; Hong, Young T.; Allinson, Kieren S. J.; Williamson, David; Borchert, Robin J.; Sami, Saber; Cope, Thomas E.; Bevan-Jones, W. Richard; Jones, P. Simon; Arnold, Robert; Surendranathan, Ajenthan; Mak, Elijah; Su, Li; Fryer, Tim D.; Aigbirhio, Franklin I.; O’Brien, John T.; Rowe, James B.

    2017-01-01

    Abstract The ability to assess the distribution and extent of tau pathology in Alzheimer’s disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies. New radioligands for positron emission tomography have generated considerable interest, and controversy, in their potential as tau biomarkers. We assessed the radiotracer 18F-AV-1451 with positron emission tomography imaging to compare the distribution and intensity of tau pathology in 15 patients with Alzheimer’s pathology (including amyloid-positive mild cognitive impairment), 19 patients with progressive supranuclear palsy, and 13 age- and sex-matched controls. Regional analysis of variance and a support vector machine were used to compare and discriminate the clinical groups, respectively. We also examined the 18F-AV-1451 autoradiographic binding in post-mortem tissue from patients with Alzheimer’s disease, progressive supranuclear palsy, and a control case to assess the 18F-AV-1451 binding specificity to Alzheimer’s and non-Alzheimer’s tau pathology. There was increased 18F-AV-1451 binding in multiple regions in living patients with Alzheimer’s disease and progressive supranuclear palsy relative to controls [main effect of group, F(2,41) = 17.5, P AV-1451 binding was significantly increased in patients with Alzheimer’s disease, relative to patients with progressive supranuclear palsy and with control subjects, in the hippocampus and in occipital, parietal, temporal, and frontal cortices (t’s > 2.2, P’s AV-1451 binding was elevated in the midbrain (t = 2.1, P AV-1451 uptake in the putamen, pallidum, thalamus, midbrain, and in the dentate nucleus of the cerebellum (t’s > 2.7, P’s AV-1451 strongly bound to Alzheimer-related tau pathology, but less specifically in progressive supranuclear palsy. 18F-AV-1451 binding to the basal ganglia was strong in all groups in vivo. Postmortem histochemical

  10. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally☆

    Science.gov (United States)

    Kyriacou, Andreas; Pabari, Punam A.; Mayet, Jamil; Peters, Nicholas S.; Davies, D. Wyn; Lim, P. Boon; Lefroy, David; Hughes, Alun D.; Kanagaratnam, Prapa; Francis, Darrel P.; I.Whinnett, Zachary

    2014-01-01

    Background The mechanoenergetic effects of atrioventricular delay optimization during biventricular pacing (“cardiac resynchronization therapy”, CRT) are unknown. Methods Eleven patients with heart failure and left bundle branch block (LBBB) underwent invasive measurements of left ventricular (LV) developed pressure, aortic flow velocity-time-integral (VTI) and myocardial oxygen consumption (MVO2) at 4 pacing states: biventricular pacing (with VV 0 ms) at AVD 40 ms (AV-40), AVD 120 ms (AV-120, a common nominal AV delay), at their pre-identified individualised haemodynamic optimum (AV-Opt); and intrinsic conduction (LBBB). Results AV-120, relative to LBBB, increased LV developed pressure by a mean of 11(SEM 2)%, p = 0.001, and aortic VTI by 11(SEM 3)%, p = 0.002, but also increased MVO2 by 11(SEM 5)%, p = 0.04. AV-Opt further increased LV developed pressure by a mean of 2(SEM 1)%, p = 0.035 and aortic VTI by 4(SEM 1)%, p = 0.017. MVO2 trended further up by 7(SEM 5)%, p = 0.22. Mechanoenergetics at AV-40 were no different from LBBB. The 4 states lay on a straight line for Δexternal work (ΔLV developed pressure × Δaortic VTI) against ΔMVO2, with slope 1.80, significantly > 1 (p = 0.02). Conclusions Biventricular pacing and atrioventricular delay optimization increased external cardiac work done but also myocardial oxygen consumption. Nevertheless, the increase in cardiac work was ~ 80% greater than the increase in oxygen consumption, signifying an improvement in cardiac mechanoenergetics. Finally, the incremental effect of optimization on external work was approximately one-third beyond that of nominal AV pacing, along the same favourable efficiency trajectory, suggesting that AV delay dominates the biventricular pacing effect — which may therefore not be mainly “resynchronization”. PMID:24332598

  11. Comparing18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease.

    Science.gov (United States)

    Mattsson, Niklas; Smith, Ruben; Strandberg, Olof; Palmqvist, Sebastian; Schöll, Michael; Insel, Philip S; Hägerström, Douglas; Ohlsson, Tomas; Zetterberg, Henrik; Blennow, Kaj; Jögi, Jonas; Hansson, Oskar

    2018-01-30

    To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD). We compared t-tau and p-tau and 18 F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (prodromal and dementia) were screened for amyloid positivity using CSF β-amyloid 42. Retention of 18 F-AV-1451 was measured in a priori specified regions, selected for known associations with tau pathology in AD. Retention of 18 F-AV-1451 was markedly elevated in Alzheimer dementia and moderately elevated in prodromal AD. CSF t-tau and p-tau was increased to similar levels in both AD dementia and prodromal AD. 18 F-AV-1451 had very good diagnostic performance for Alzheimer dementia (area under the receiver operating characteristic curve [AUROC] ∼1.000), and was significantly better than t-tau (0.876), p-tau (0.890), hippocampal volume (0.824), and temporal cortical thickness (0.860). For prodromal AD, there were no significant AUROC differences between CSF tau and 18 F-AV-1451 measures (0.836-0.939), but MRI measures had lower AUROCs (0.652-0.769). CSF tau and 18 F-AV-1451 have equal performance in early clinical stages of AD, but 18 F-AV-1451 is superior in the dementia stage, and exhibits close to perfect diagnostic performance for mild to moderate AD. This study provides Class III evidence that CSF tau and 18 F-AV-1451 PET have similar performance in identifying early AD, and that 18 F-AV-1451 PET is superior to CSF tau in identifying mild to moderate AD. © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  12. Prediktion av översvämningsrisken vid vägar - En undersökning av två översvämningar i Östersunds kommun 2008.

    OpenAIRE

    Davidsson, Emil; Persson, Erik

    2015-01-01

    Pågående klimatförändringar med påföljande ökad nederbörd ger förhöjd risk för översvämningar. Det är därför viktigt att kunna göra förutsägelser för var översvämning riskerar att ske. Förutsättningarna att göra sådana prediktioner med geografiska informationssystem ökar då Sveriges geografi karteras i allt större utsträckning. Syftet med uppsatsen är att utföra och analysera en modell för kartering av översvämningsrisk av väg. Det görs genom GIS-analys av geografiska data, baserade på platss...

  13. Ett arbete om förändringen sedan införandet av IAS36 och IAS38

    OpenAIRE

    Widing, Robert; Söderberg, Kristian

    2007-01-01

    Sedan införandet av IFRS har en rad nya regler tillkommit. Den här uppsatsen beskriver förändringarna kring införandet av IAS 36 och 38. Den empiriska undersökningen avser intervjuer med två revisionsbyråer samt ett företag. Vår slutsats har visat att sedan införandet av IFRS 3 så har det inte behövts göras några nedskrivningar. Till grund för detta ligger den rådande högkonjunkturen. När konjunkturen vänder kan vi vänta oss att företagen kommer att behöva skriva ner sina tillgångar. Dock har...

  14. Compostagem de resíduo sólido de abatedouro avícola

    Directory of Open Access Journals (Sweden)

    Natália da Silva Sunada

    2015-01-01

    Full Text Available Em virtude da grande demanda por proteína de origem animal, tem-se aumentado a produção de frangos de corte e consequentemente a geração de resíduos provenientes do abate de aves, sendo necessário o desenvolvimento de técnicas que permitam o aproveitamento e reciclagem desses materiais. Objetivou-se com a execução deste trabalho avaliar a eficiência da compostagem no tratamento e reciclagem do resíduo sólido de abatedouro avícola. Utilizou-se resíduo sólido de abatedouro avícola comercial composto por fragmentos de vísceras, tecido muscular, adiposo e ósseo, sangue coagulado e penas e, como fonte de carbono, a casca de arroz. Montou-se uma leira com 1,5m3 de volume inicial, na qual foram monitorados os parâmetros: temperatura, teores de sólidos totais (ST, voláteis (SV, N, P, K, carbono orgânico (C, matéria orgânica compostável (MOC, matéria orgânica resistente à compostagem (MORC, demanda química de oxigênio (DQO, massa e volume enleirados, número mais provável (NMP de coliformes totais e termotolerantes, bem como suas reduções durante o processo. A temperatura máxima atingida no centro da leira foi de 53,3ºC (média semanal, já as reduções de massa de ST e SV e volume durante o processo de pré-compostagem foram de 36,1; 44,3 e 23,3%, respectivamente, e, durante o processo de compostagem, foram de 21,8; 23,8 e 4,4%. A baixa redução do volume das leiras pode estar associada à alta concentração de MORC (40,1% que pode ser principalmente relacionada à qualidade da fonte de carbono. O processo promoveu satisfatórias reduções totais de ST, SV e volume, sendo, respectivamente, 50,1; 57,5 e 26,7%. No entanto, foram observadas reduções de 43% na quantidade de nitrogênio presente no composto final. Apesar das reduções de nitrogênio, a compostagem demonstrou ser um método eficiente no tratamento dos resíduos sólidos de abatedouro avícola.

  15. Lovligheten av utleie på Airbnb - Kan utleie på Airbnb medføre tvangssalg?

    OpenAIRE

    Isaksen, Marie

    2017-01-01

    Emnet for oppgaven er lovligheten av utleie av eierseksjonsleiligheter på Airbnb. Oppgaven skal belyse om utleie gjennom Airbnb kan medføre vesentlig mislighold, og dermed gi grunnlag for tvangssalg. Det fokusere på fire forhold som kan føre til at utleie på Airbnb kan medføre vesentlig mislighold; bruk i strid med vedtekter, bruk i strid med husordensregler, formålsstridig bruk, og bruk til unødvendig eller urimelig ulemper eller skader for naboene.

  16. Kommunikasjonskultur i sosiale medier i Japan og Norge. Sammenlikning av smarttelefon-apper mellom LINE og Facebook Messenger

    OpenAIRE

    Abumi, Asaki

    2015-01-01

    Denne oppgaven analyser hvordan norske og japanske brukere kommuniserer på sosiale medier på smarttelefoner. Analysen er basert på en spørreundersøkelse med 20 deltagere fra Japan som bruker appen LINE, og 20 deltagere fra Norge som bruker Facebook Messenger. Informantene består av unge universitetsstudenter fra 18 til 25 år. Resultatene viser blant annet at japanere foretrekker LINE fordi den har et stort utvalg av søte sticker, som gjør kommunikasjon lettere for japanere som bor i et stort ...

  17. Bland prinsessor och soldater : En kvalitativ innehållsanalys av genus och stereotyper i två Disneyfilmer

    OpenAIRE

    Jonsson, Andreas

    2014-01-01

    Syfte: Syftet med den här uppsatsen är att undersöka hur genus representeras och hur feministisk kritik syns i Disneyfilmerna Mulan och Frost. Arbetet behandlar kopplingen till tidigare Disneyfilmer och stereotypa framställningar av manligt och kvinnligt. Det utgår från ett genusperspektiv som tar hänsyn till könsroller som är resultatet av sociala konstruktioner. Metod: Filmerna har studerats i sin helhet och sedan har specifika scener och sekvenser valts ut för närmare studie. De har analys...

  18. För vilka finns kroppspositivismen? : En diskursanalytisk och semiotisk studie av hur kroppsaktivister på Instagram artikulerar kroppspositivism

    OpenAIRE

    Wallén, Camilla

    2017-01-01

    Denna studie har genomförts med syfte att undersöka hur kroppsaktivister artikulerar kropp och kroppspositivitet genom bilder och texter på deras Instagramkonton. Studien syftar även till att undersöka om, och i så fall hur, artikulationerna av kroppspositivitet skiljer sig mellan olika kroppsaktivister. Slutligen syftar studien till att studera hur kroppsaktivisterna artikulerar syftet med rörelsen. Det teoretiska ramverket består av tidigare forskning och etablerade teorier i postmodern fem...

  19. Nordkapp som bærekraftig destinasjon - Et case-studie av aktørers drivere og barrierer

    OpenAIRE

    Berg, Marianne; Røkholt, Solveig

    2016-01-01

    Tittelen på oppgaven er “Nordkapp som bærekraftig destinasjon: Et case-studie av aktørers drivere og barrierer”. Vi har utviklet problemstillingen: “Hvilke drivere og barrierer ligger til grunn for utviklingen av et bærekraftig reiseliv blant aktørene på destinasjon Nordkapp?” Temaet vi ønsker å ta for oss er derfor bærekraftig destinasjonsutvikling på naturdestinasjoner. Bærekraft er en tematikk som må tas hensyn til for reiselivets overlevelsesevne. For å undersøke dette har vi brukt et kva...

  20. Jean-Michel Basquiat- : en undersøkelse av tre arbeider på papir fra 1982-1983

    OpenAIRE

    Langebrekke, Josephine

    2011-01-01

    Jean-Michel Basquiats (1960–1988) produksjon har vært gjenstand for et konservert forskningsparadigme hvor det biografiske materialet som ligger til grunn, har fått spille en dominerende rolle i møte med verkene. Formålet med denne oppgaven har vært å foreta en analyse av tre arbeider på papir fra perioden 1982–1983; Undiscovered Genius, Ascent og 50¢ Piece, med vekt på dekoding av tekst og tegn for å gjennomgå verkenes narrative fremstilling, ekstrahert fra alt personlig-relatert materiale s...

  1. Elektronová mikroskopie, mikroanalýza a difrakce na ÚMCH AV ČR

    Czech Academy of Sciences Publication Activity Database

    Šlouf, Miroslav; Pavlova, Ewa; Králová, Daniela; Hromádková, Jiřina; Vlková, Helena; Lapčíková, Monika

    2010-01-01

    Roč. 17, 2a (2010), k46-k49 ISSN 1211-5894. [Struktura 2010. Soláň, 14.06.2010-17.06.2010] R&D Projects: GA AV ČR KAN200520704; GA ČR GAP205/10/0348 Institutional research plan: CEZ:AV0Z40500505 Keywords : introduction to electron microscopy * electron spectroscopy * electron diffraction Subject RIV: EB - Genetics ; Molecular Biology http:// xray .cz/ms/bul2010-2a/slouf.pdf

  2. Prototyptillverkning i plast med FriFormFramställning : - handledning vid val av FFF-metod

    OpenAIRE

    Dahlman, Maria; Olsson, Ulrika

    2012-01-01

    FriFormFramställning är en additiv tillverkningsteknik, vilken innebär att detaljen byggs upp lager för lager, genom att material successivt tillförs. En vanlig tillämpning av denna metod är tillverkning av prototyper i plast. Metoden har blivit populär främst tack vare dess möjlighet att reducera ledtiden. Teknikens förmåga att skapa komplexa geometrier, vilka inte alltid kan tillverkas med klassisk tillverkning som bygger på svarv- och fräsoperationer, har också bidragit till dess popularit...

  3. Kalkulerende kjeltringer eller offer for omstendighetene? En kvalitativ studie av heroinomsetningens utvikling og aktører

    OpenAIRE

    Snertingdal, Mette Irmgard

    2007-01-01

    - De ulike posisjonene i heroinomsetningen i Norge er for første gang belyst via fengselsintervjuer. Studien viser at selgerne står relativt fritt til å velge sine leverandører. Storselgerne er drevet av jakten på store penger mens småselgerne primært finansierer egen rusmiddelbruk. De øverste sjiktene i heroinimporten til Norge synes å være styrt av personer i utlandet via slektskapsbånd. De driver illegal virksomhet for å forsørge sine familier. Dette er blant hovedkonklusjonene i SIRUS-...

  4. Desórdenes muscoloesqueléticos en el trabajador avícola – intervenciones en salud

    OpenAIRE

    Barajas, Maryi Lizeth; Aceveo, Sharom Irene

    2016-01-01

    Introducción: El trabajador avícola presenta un alto riesgo de sufrir de Desórdenes Musculo esqueléticos, debido a la realización de trabajos manuales repetitivos; posición bípeda prolongada, posturas por fuera de ángulos de confort de miembros superiores Objetivo: Establecer las recomendaciones basadas en la evidencia de las intervenciones en salud para los Desórdenes Musculoesqueléticos (DME) en el trabajador avícola. Metodología: Se realizó una revisión de la literatura de los estudi...

  5. Norske kostholdsanbefalinger av mettet fett, med fokus på anbefalinger om fett i melk til barn : en litteraturstudie

    OpenAIRE

    Bjørgum, Bente

    2015-01-01

    I sin begynnelse var myndighetenes kostholdsanbefalinger basert på å beskytte befolkningen mot ernæringsmangler og underernæring. Hypotesen om at for mye fett i kostholdet, og spesielt mettet fett gir økt risiko for utvikling av hjerte- og karsykdommer har påvirket kostholdsanbefalingene i Norge siden 1970 tallet og helt fram til i dag. Også livsstilssykdommer som diabetes type 2, kreft, fedme og metabolsk syndrom var satt i sammenheng med bruk av fett, og spesielt mettet fett i kosthol...

  6. SVÅRIGHETER VID CERTIFIERING AV KVALITETSLEDNINGSSYSTEMET ISO 9001:2015 FÖR SMÅ FÖRETAG

    OpenAIRE

    Andersson, Molly; Andersén, Lovisa

    2016-01-01

    Studien syftar till att upptäcka svårigheter vid implementering av kvalitetsledningssystemet ISO 9001:2015 på små företag. För att uppnå studiens syfte samlades teorier om kvalitetsledningssystemet ISO 9001 och dess implementerings- och certifieringsprocess in. En fallstudie genomfördes på två analysenheter för att sedan jämföras mot det teoretiska ramverket och erhålla ett resultat. De mest bidragande faktorerna till icke-certifiering av ISO 9001 hos små företag visade sig vara tidsbrist, re...

  7. Observation infrastructure for airborne hazards in the framework of the EUNADICS-AV project

    Science.gov (United States)

    Mona, Lucia; Pappalardo, Gelsomina; Stammes, Piet; Lihavainen, Heikki; Paatero, Jussi; Hirtl, Marcus; Schlager, Hans; Graf, Kaspar; Hedelt, Pascal; Theys, Nicolas; Coltelli, Mauro; Vargas, Arturo; Clarisse, Lieven; Nína Petersen, Guðrún; de Leeuw, Gerrit; Papagiannopoulos, Nikolaos; Apituley, Arnoud; Haefele, Alexander; Delcloo, Andy; Wotawa, Gerhard

    2017-04-01

    During the 2010 and 2011 Icelandic volcanic eruptions, the availability of integrated, validated data sets was identified as a major challenge in the effort to gain a rapid situation assessment. These environmental crisis situations may happen again, also from other types ofairborne hazards, like big fires. Currently, the issue is not so much that data and observations do not exist, it is rather the rapid accessibility, the cross-calibration of different sensors, the integration of new platforms and the harmonization of standards and protocols that needs further work and attention. A specific activity is planned within the H-2020 project EUNADICS -AV ("European Natural Disaster Coordination and Information System for Aviation") for addressing this critical issue. In order to achieve the rapid data accessibility, work will be carried out with full consideration of the main European Research Infrastructures, projects and national/international monitoring networks that are able to provide crucial information related to the dispersion of airborne hazards. The integrated data sets are based on satellite and ground-based remote sensing as well as in situ ground-based and aircraft observations. Networks of ground based remote sensing of atmospheric profiles are particularly important, since these will provide the needed height information that cannot be obtained unambiguously from the vast majority of space borne sensors. A new aspect not treated in any project and initiative so far is the integration of special crisis measurements, for example by aircraft or UAV systems. Particularly suited for the purposes of the project are satellite data from operational sensors aboard EUMETSAT and ESA satellites. Improved retrievals are investigated, and the new generation of Sentinel satellites currently being launched under the Copernicus umbrella and their added value are considered. Especially when the ground based and space borne observations are combined, the much needed

  8. Videos for Science Communication and Nature Interpretation: The TIB|AV-Portal as Resource.

    Science.gov (United States)

    Marín Arraiza, Paloma; Plank, Margret; Löwe, Peter

    2016-04-01

    Scientific audiovisual media such as videos of research, interactive displays or computer animations has become an important part of scientific communication and education. Dynamic phenomena can be described better by audiovisual media than by words and pictures. For this reason, scientific videos help us to understand and discuss environmental phenomena more efficiently. Moreover, the creation of scientific videos is easier than ever, thanks to mobile devices and open source editing software. Video-clips, webinars or even the interactive part of a PICO are formats of scientific audiovisual media used in the Geosciences. This type of media translates the location-referenced Science Communication such as environmental interpretation into computed-based Science Communication. A new way of Science Communication is video abstracting. A video abstract is a three- to five-minute video statement that provides background information about a research paper. It also gives authors the opportunity to present their research activities to a wider audience. Since this kind of media have become an important part of scientific communication there is a need for reliable infrastructures which are capable of managing the digital assets researchers generate. Using the reference of the usecase of video abstracts this paper gives an overview over the activities by the German National Library of Science and Technology (TIB) regarding publishing and linking audiovisual media in a scientifically sound way. The German National Library of Science and Technology (TIB) in cooperation with the Hasso Plattner Institute (HPI) developed a web-based portal (av.tib.eu) that optimises access to scientific videos in the fields of science and technology. Videos from the realms of science and technology can easily be uploaded onto the TIB|AV Portal. Within a short period of time the videos are assigned a digital object identifier (DOI). This enables them to be referenced, cited, and linked (e.g. to the

  9. Independent effects of apolipoprotein AV and apolipoprotein CIII on plasma triglyceride concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Baroukh, Nadine N.; Bauge, Eric; Akiyama, Jennifer; Chang, Jessie; Fruchart, Jean-Charles; Rubin, Edward M.; Fruchart, Jamila; Pennacchio, Len A.

    2003-08-15

    Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are negatively and positively correlated with APOA5 and APOC3 expression, respectively. In humans, common polymorphisms in both genes have also been associated with plasma triglyceride concentrations. The evolutionary relationship among these two apolipoprotein genes and their close proximity on human chromosome 11q23 have largely precluded the determination of their relative contribution to altered Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are negatively and positively correlated with APOA5 and APOC3 expression, respectively. In humans, common polymorphisms in both genes have also been associated with plasma triglyceride concentrations. The evolutionary relationship among these two apolipoprotein genes and their close proximity on human chromosome 11q23 have largely precluded the determination of their relative contribution to altered triglycerides. To overcome these confounding factors and address their relationship, we generated independent lines of mice that either over-expressed (''double transgenic'') or completely lacked (''double knockout'') both apolipoprotein genes. We report that both ''double transgenic'' and ''double knockout'' mice display intermedia tetriglyceride concentrations compared to over-expression or deletion of either gene alone. Furthermore, we find that human ApoAV plasma protein levels in the ''double transgenic'' mice are approximately 500-fold lower than human ApoCIII levels, supporting ApoAV

  10. A Comparison of Interaction in AV-based and Internet-based Distance Courses

    Directory of Open Access Journals (Sweden)

    Melodee Landis

    2001-04-01

    Full Text Available At the center of the debate over the viability of distance education is whether the newer electronic technologies can offer enough interaction to maintain quality learner outcomes and critical mass. Two of the most commonly used forms of distance education are 1 two-way, fully interactive audio-video classrooms and 2 on-line instruction through the Internet or Worldwide Web. This study used qualitative methods to compare and contrast the interaction that occurred in distance learning courses offered via each medium. The research process confirmed findings that there were fundamental differences in the interaction that occurred in the two environments. On-line interaction is so profoundly different than interaction in the traditional and AV-based class room that it appears instructors and students will need a substantial period of adjustment to feel comfortable with it and to fully appreciate its value. It appears that, as distance teaching and learning moves to a “mixed media” approach to teaching and learning, how interaction is handled with each of the media may be important to the success of a distance program.

  11. Å skape et begrep om jam i utforskningen av en deleuziansk metode-ontologi

    Directory of Open Access Journals (Sweden)

    Ola Harstad

    2017-12-01

    Full Text Available Å forske med kunsten innebærer ikke bare valget av visse metoder for bruk i forskningsprosessen, men også om å ha til disposisjon spesifikke måter å tenke om metode. I denne artikkelen vil jeg synliggjøre en tenkemåte fundert i arbeidet med en skjønnlitterær lesesirkel for lærerstudenter, og min egen erfaring som improvisasjonsmusiker. Jazzens begrep om jam blir løftet frem som omdreiningspunkt for tenkemåten, som ellers har sitt teoretiske utspring i den franske filosofen Gilles Deleuze’s forestilling om bliven. Denne vitale forestillingen innebærer at verden produseres kontinuerlig, noe forskeren også bidrar til. Koblingen mellom jam, litteratur og Deleuze synliggjør dessuten en måte å tenke om metode på som understreker at det å forske med kunsten ikke bare betyr å forske på kunsten, men at kunsten på ulike måter kan virke inn på selve forskningen og slik også bidra til å affirmere verden i sin bliven. I tillegg til å tilby en måte å tenke om metode for den som skal forske med kunsten, er hensikten med artikkelen å gjøre forskeren bevisst sin egen tenkning om metode, noe som er viktig siden denne skaper mulighetsbetingelser for metodevalg og -bruk.

  12. Estrategias flexibilizadoras aplicadas por las empresas del sector avícola del estado Zulia

    Directory of Open Access Journals (Sweden)

    María Bonomie

    2008-01-01

    Full Text Available El artículo tiene como objetivo, analizar las estrategias flexibilizadoras aplicadas en el proceso productivo por las empresas del sector avícola, específicamente las empresas productoras de pollo del estado Zulia. Para tal fin, se describe el proceso productivo de estas empresas y además se identifican las estrategias aplicadas considerando los acontecimientos económicos influenciados por cambios políticos que en los últimos años han incidido en las empresas productoras de pollo. Se realizó una revisión bibliográfica para determinar los criterios de clasificación de las estrategias, asumiendo la establecida por Gamboa y col. (2001. Se diseñó un instrumento semiestructurado, el cual fue administrado a los gerentes y trabajadores de las empresas analizadas. Los resultados obtenidos reflejan, que las empresas utilizan las estrategias con la finalidad de reestructurar y modernizar sus procesos productivos, mejorar continuamente sus productos e introducir nueva tecnología. Se concluye que estas empresas logran incrementar la productividad, aumentando la cantidad de productos ante la utilización óptima de los recursos humanos y tecnológicos, optimización que implica una reducción de costos de producción para poder expandirse y ofrecer precios competitivos en el mercado.

  13. Unified transform architecture for AVC, AVS, VC-1 and HEVC high-performance codecs

    Science.gov (United States)

    Dias, Tiago; Roma, Nuno; Sousa, Leonel

    2014-12-01

    A unified architecture for fast and efficient computation of the set of two-dimensional (2-D) transforms adopted by the most recent state-of-the-art digital video standards is presented in this paper. Contrasting to other designs with similar functionality, the presented architecture is supported on a scalable, modular and completely configurable processing structure. This flexible structure not only allows to easily reconfigure the architecture to support different transform kernels, but it also permits its resizing to efficiently support transforms of different orders (e.g. order-4, order-8, order-16 and order-32). Consequently, not only is it highly suitable to realize high-performance multi-standard transform cores, but it also offers highly efficient implementations of specialized processing structures addressing only a reduced subset of transforms that are used by a specific video standard. The experimental results that were obtained by prototyping several configurations of this processing structure in a Xilinx Virtex-7 FPGA show the superior performance and hardware efficiency levels provided by the proposed unified architecture for the implementation of transform cores for the Advanced Video Coding (AVC), Audio Video coding Standard (AVS), VC-1 and High Efficiency Video Coding (HEVC) standards. In addition, such results also demonstrate the ability of this processing structure to realize multi-standard transform cores supporting all the standards mentioned above and that are capable of processing the 8k Ultra High Definition Television (UHDTV) video format (7,680 × 4,320 at 30 fps) in real time.

  14. Aeromonas molluscorum Av27 is a potential tributyltin (TBT) bioremediator: phenotypic and genotypic characterization indicates its safe application.

    Science.gov (United States)

    Cruz, Andreia; Areias, Dário; Duarte, Ana; Correia, António; Suzuki, Satoru; Mendo, Sónia

    2013-09-01

    Aeromonas molluscorum Av27 is an estuarine bacterium highly resistant to tributyltin (TBT). Also, the strain is able to degrade TBT into the less toxic compounds dibutyltin and monobutyltin. Therefore, this bacterium has potential to be employed in bioremediation processes. In this context, defining its biological safety is crucial. With that purpose a number of intrinsic characteristics, usually present/associated with virulent strains, were investigated. Few virulence factors were detected in strain Av27. For instance, a DNase gene is present, but it is not apparently expressed in vitro. Motility, adherence factor and phospholipase activity were also detected. Additionally, cytotoxicity to Vero cells was negative. Resistance to penicillin (10 μg ml(-1)), amoxicillin/clavulanic acid (30 μg ml(-1)) and cephalothin (30 μg ml(-1)) and also to the vibriostatic agent O/129 was observed. Five plasmids (4, 7, 10, 100 kb and one greater than 100 kb) were identified. No Class I and II integrons were detected. Study of the optimal growth conditions showed that Av27 easily adapts to different environmental conditions. Overall, the results suggest that A. molluscorum Av27 can be considered safe to use to bioremediate TBT in contaminated environments.

  15. Iodine sorption by ion-exchange fiber on the basis of polyacrylonitrile and AV-17 anionite under static conditions

    International Nuclear Information System (INIS)

    Tarchigina, N.I.; Artemov, A.V.; Ksenzenko, V.I.

    1986-01-01

    Iodine sorption from natural waters by a qualitatively new sorbent - ion-exchange fiber on the basis of polyacrylonitrile and AV-17 anionite is investigated. Mechanism of iodine sorption by ion-exchange material is suggested. Iodine sorption kinetics by fibrous sorbent under static conditions is described. Iodine sorption efficient constants are determined by experimental data processing with the use of electronic computer

  16. THE SORPTION EXTRACTION FEATURES OF KARMOAZONATE MERCURY(I COMPLE X BY ANION EXCHANGER AV-17-8 SURFACE

    Directory of Open Access Journals (Sweden)

    Н. M. Guzenko

    2014-11-01

    Full Text Available The dynamic and kinetic curves were analyzed, they were obtained by karmoazonate mercury(I complex extraction by anion exchanger AV-17-8 surface, and also calculated values of sorption process speed factor have allowed to establish the features of the adsorption layers formation on the resin surface.

  17. 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

    Science.gov (United States)

    Puschmann, Andreas; Schöll, Michael; Ohlsson, Tomas; van Swieten, John; Honer, Michael; Englund, Elisabet

    2016-01-01

    Abstract Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo. However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with 18F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau. This mutation results in 3- and 4-repeat tau aggregates similar to those in Alzheimer’s disease, and many of the mutation carriers initially suffer from memory impairment and temporal lobe atrophy. Two patients with short disease duration and isolated memory impairment exhibited 18F-AV-1451 uptake mainly in the hippocampus and adjacent temporal lobe regions, correlating with glucose hypometabolism in corresponding regions. One patient died after 26 years of disease duration with dementia and behavioural deficits. Pre-mortem, there was 18F-AV-1451 uptake in the temporal and frontal lobes, as well as in the basal ganglia, which strongly correlated with the regional extent and amount of tau pathology in post-mortem brain sections. Amyloid-β (18F-flutemetamol) positron emission tomography scans were negative in all cases, as were stainings of brain sections for amyloid. This provides strong evidence that 18F-AV-1451 positron emission tomography can be used to accurately quantify in vivo the regional distribution of hyperphosphorylated tau protein. PMID:27357347

  18. Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease.

    Science.gov (United States)

    Schöll, Michael; Ossenkoppele, Rik; Strandberg, Olof; Palmqvist, Sebastian; Jögi, Jonas; Ohlsson, Tomas; Smith, Ruben; Hansson, Oskar

    2017-09-01

    Patients with Alzheimer's disease can present with different clinical phenotypes. Individuals with late-onset Alzheimer's disease (>65 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early-onset Alzheimer's disease (AV-1451 tau positron emission tomography and structural magnetic resonance imaging to explore whether early- and late-onset Alzheimer's disease exhibit differential regional tau pathology and atrophy patterns. Strong associations of lower age at symptom onset with higher 18F-AV-1451 uptake were observed in several neocortical regions, while higher age did not yield positive associations in neither patient group. Comparing patients with early-onset Alzheimer's disease with controls resulted in significantly higher 18F-AV-1451 retention throughout the neocortex, while comparing healthy controls with late-onset Alzheimer's disease patients yielded a distinct pattern of higher 18F-AV-1451 retention, predominantly confined to temporal lobe regions. When compared against each other, the early-onset Alzheimer's disease group exhibited greater uptake than the late-onset group in prefrontal and premotor, as well as in inferior parietal cortex. These preliminary findings indicate that age may constitute an important contributor to Alzheimer's disease heterogeneity highlighting the potential of tau positron emission tomography to capture phenotypic variation across patients with Alzheimer's disease. © The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain.

  19. Velké infrastruktury v Ústavu fyziky plazmatu AV ČR, v. v. i

    Czech Academy of Sciences Publication Activity Database

    Křenek, Petr; Chráska, Pavel

    -, č. 3 (2011), s. 18-20 ISSN 1214-7982 Institutional research plan: CEZ:AV0Z20430508 Keywords : photodissociation iodine laser * PALS * fusion * tokamak * COMPASS Subject RIV: BL - Plasma and Gas Discharge Physics http://www.tc.cz/dokums_raw/echo32011internet_59.pdf

  20. Automated and connected vehicle (AV/CV) test bed to improve transit, bicycle, and pedestrian safety : concept of operations plan.

    Science.gov (United States)

    2017-02-01

    This document presents the Concept of Operations (ConOps) Plan for the Automated and Connected Vehicle (AV/CV) Test Bed to Improve Transit, Bicycle, and Pedestrian Safety. As illustrated in Figure 1, the plan presents the overarching vision and goals...

  1. In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Day, Gregory S; Gordon, Brian A; Perrin, Richard J; Cairns, Nigel J; Beaumont, Helen; Schwetye, Katherine; Ferguson, Cole; Sinha, Namita; Bucelli, Robert; Musiek, Erik S; Ghoshal, Nupur; Ponisio, Maria R; Vincent, Benjamin; Mishra, Shruti; Jackson, Kelley; Morris, John C; Benzinger, Tammie L S; Ances, Beau M

    2018-03-06

    To determine whether specific patterns of [ 18 F]-AV-1451 tau-PET retention are observed in patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD). In vivo [ 18 F]-AV-1451 PET neuroimaging was performed in 5 patients with sporadic CJD (median age, 66 years [63-74]), and results were compared to cognitively normal (CN) persons (n = 44; median age, 68 years [63-74]) and to participants with very mild Alzheimer disease (AD) dementia (n = 8; median age, 77 years [63-90]). Autopsy was completed in all patients with CJD, confirming the clinical diagnosis and permitting characterization of AD neuropathologic change (ADNC). All patients with CJD presented with rapidly progressive dementia, typical magnetic resonance brain imaging changes, and elevated CSF total tau (median = 6,519; range = 1,528-13,240 pg/mL). Death occurred within 9 months of symptom onset, with a median 1 month (0.2-3.3) interval from [ 18 F]-AV-1451 PET to autopsy. No unique pattern of [ 18 F]-AV-1451 retention was observed on visual inspection. Summary standardized uptake value ratios in patients with CJD (1.17, 1.08-1.36) were indistinguishable from CN persons (1.14, 0.84-1.54; p = 0.6), and well below those of participants with AD (2.23, 1.60-3.04; p ≤ 0.01). [ 18 F]-AV-1451 retention in patients with CJD and CN persons was similar in brain areas frequently affected in AD and CJD. Neuropathologic analysis confirmed the clinical diagnosis in all patients with CJD. Four patients with CJD also had low-level ADNC (A1B1C0); one patient had intermediate-level ADNC (A2B2C1/2). Increased [ 18 F]-AV-1451 retention was not observed in patients with rapidly progressive dementia due to sporadic CJD. The [ 18 F]-AV-1451 PET tracer maintains good specificity for paired helical tau filaments associated with AD dementia. © 2018 American Academy of Neurology.

  2. E-Læring som pedagogisk virkemiddel for innlæring av anatomi, fysiologi og biokjemi i sykepleierutdanningen

    Directory of Open Access Journals (Sweden)

    Mona Elisabeth Meyer

    2014-02-01

    Full Text Available Utgangspunktet for studien er at naturvitenskaplige fag, særlig anatomi, fysiologi og biokjemi (AFB, oppleves som vanskelig for sykepleierstudentene. Hensikten var å undersøke om læringsverktøyet e-læring, i form av nettester, kan være et effektivt virkemiddel til innlæring av og påvirke læringsutbyttet i AFB.Førsteårsstudentene i bachelorutdanningen i sykepleie ved Høgskolen i Akershus fikk et spørreskjema med 23 spørsmål som ble besvart anonymt.Resultatet av studentundersøkelsen viste at nettoppgavene ble mye brukt, og at studentene mente de ga et godt læringsutbytte. Nettoppgaver med umiddelbar feedback gir stor studentaktivitet og «time-on-task». Testene kan tette hullet mellom det studentene forventes å kunne og det de faktisk kan, og egner seg til faktafag som m å pugges og forstås. E-læring kan gi god hjelp til studenters strukturering av tid, læringsstrategier og selvregulering.Læringsutbyttet av nettester diskuteres i lys av nytten av umiddelbar feedback i et pedagogisk perspektiv.AbstractThe starting point of the study is that the natural sciences, particularly anatomy, physiology and biochemistry (collectively known as APB, are often difficult subjects for nursing students. The aim was to investigate whether e-learning tools, in terms of web services, can be an effective educational tool and affect learning outcomes in APB.First year students in the Bachelor's degree program in nursing at Akershus University College of Applied Sciences received a questionnaire with 23 questions, which were answered anonymously.The results of the student survey showed that online tasks were widely used, and that students felt they resulted in good learning outcomes. Online training with immediate feedback shows great student activity and “time-on-task.” These tests can close the gap between what the students are expected to know and what they actually do, and is suitable for factual subjects requiring both memorization and

  3. Offshore vindenergianlegg - sjøfugl, havørn, hubro og vadere. En screening av potensielle konfliktområde

    OpenAIRE

    Christensen-Dalsgaard, Signe; Lorentsen, Svein-Håkon; Dahl, Espen Lie; Follestad, Arne; Hanssen, Frank Ole; Systad, Geir Helge

    2010-01-01

    Christensen-Dalsgaard, S., Lorentsen, S.-H., Dahl, E. L., Follestad, A., Hanssen, F. & Systad, G. H. 2010. Offshore vindenergianlegg - sjøfugl, havørn, hubro og vadere. En screening av potensielle konfliktområder - NINA Rapport 557. 100 s. Målet for foreliggende studie var å utarbeide en beslutningsrelevant, storskala screening av områder som kan være aktuelle for etablering av offshore vindenergianlegg med lavest mulig konfliktrisiko i forhold til forekomster av sjøfugl, vader...

  4. Nære pårørende av alkoholmisbrukere - hvor mange er de og hvordan berøres de?

    OpenAIRE

    Rossow, Ingeborg; Moan, Inger Synnøve; Natvig, Henrik

    2009-01-01

    - Alkohol står for det største omfanget av rusmiddelproblemer i Norge, både med hensyn til hvor mange personer som har et rusmiddelproblem og omfanget av de helsemessige og sosiale konsekvensene av rusmiddelbruken. Denne rapporten omhandler de negative konsekvensene av alkoholbruk for nære pårørende som barn og ektefelle/partner. Både spørsmålet om hvor mange nære pårørende det er til alkoholmisbrukere og hva slags negative konsekvenser de erfarer, blir for første gang ve...

  5. Djur som stöd i demensvården : Hur personer med demenssjukdom påverkas av djur i omvårdnaden

    OpenAIRE

    Olménius, Fanny; Boström, Anna

    2017-01-01

    Bakgrund: Varje år insjuknar uppskattningsvis 25 000 personer i Sverige i någon form av demenssjukdom. Behovet av anpassad vård för denna specifika grupp kräver nya och även utvecklade omvårdnadsmetoder. I nuläget finns ingen botande behandling för de olika demenssjukdomarna, utan fokus ligger vid att mildra besvären av sjukdomsbundna symtom. Animal-assisted therapy (AAT) och Animal-assisted activity (AAA) har blivit allt mer populärt inom olika områden av omvårdnadsarbete. Djur kan inverka p...

  6. Bistand for utvikling. Effekten av handelsrelatert bistand på økonomisk utvikling i land sør for Sahara

    OpenAIRE

    Bjerke, Marielle Veneranda

    2015-01-01

    Hensikten med denne oppgaven er å undersøke effekten av handelsrelatert bistand på økonomisk utvikling. Problemstillingen er som følger: Har den direkte effekten av handelsrelatert bistand en positiv effekt på økonomisk utvikling i land sør for Sahara, eller er effekten betinget av institusjonell kvalitet? Resultatene fra analysen ga signifikante resultater på den direkte effekten av handelsrelatert bistand på økonomisk utvikling. Det er ingen signifikante resultater i forholdet mellom de be...

  7. Fair play i kroppsøvingsfaget i lys av aristotelisk dydsetikk

    Directory of Open Access Journals (Sweden)

    Ove Ronny Olsen Sæle

    2013-05-01

    Full Text Available Artikkelen ønsker å gi et konstruktivt bidrag til forståelsen og anvendelsen av fair play i en kroppsøvingsfaglig kontekst. Dette er et tema som er blitt aktualisert i og med at fair play er kommet inn som et sentralt element i kroppsøvingsfagets nye reviderte læreplan. Fair play omhandler regler, normer og verdier som skal gjelde ved idrettsutøvelse, og det er et etablert verdikonsept innenfor organisert idrettsliv og idrettsetisk forskning. I skolen, derimot, er fair play mindre kjent. Kroppsøvingsplanen hevder fair play omfatter aspekter ved idrettsspillet som å overholde regler, vise hverandre respekt og gjøre hverandre gode. Hva betyr så dette? Hva vil det si å gjøre hverandre gode? Rommer det bare en teknisk eller også en sosialetisk kvalitet? Dersom det siste er tilfelle, bør det diskuteres hvilke danningskvaliteter det så ligger i det å gjøre hverandre gode i faget, og om disse har noen tilknytningspunkt til Aristoteles' klassiske dyder om rettferdighet, måtehold, mot og klokskap. Dette er de sentrale spørsmålene artikkelen reiser og prøver å gi noen svar på. Artikkelen ser først på fair play i kroppsøvingsfagets planer, for deretter å gi begrepet en nærmere etymologisk og ideologisk-historisk avklaring, med utgangspunkt i begrepene «fair» og «play». Videre drøftes fair play i lys av de aristoteliske dydene, relatert til kroppsøvingsfaglig kontekst og diskurs.Nøkkelord: kroppsøving, fair play, idrett, lek og danningEnglish summary: Fair play in Physical Education in the light of Aristotelian virtue ethicsThe aim of this article is to give a constructive contribution to the understanding and the application of the concept of fair play in the Physical Education context. This is a topic that has come into focus since fair play has been introduced as a central element in the newest revision of the subject curriculum. Fair play concerns the rules, norms, and values that apply to sports activities, and

  8. European Natural Disaster Coordination and Information System for Aviation (EUNADICS-AV)

    Science.gov (United States)

    Wotawa, Gerhard; Hirtl, Marcus; Arnold, Delia; Katzler-Fuchs, Susanne; Pappalardo, Gelsomina; Mona, Lucia; Sofiev, Mikhail; de Leeuw, Gerrit; Theys, Nicolas; Brenot, Hugues; Plu, Matthieu; Rockitansky, Carl-Herbert; Eschbacher, Kurt; Apituley, Arnoud; Som de Cerff, Wim

    2017-04-01

    Commercial aviation is one of the key infrastructures of our modern world. Even short interruptions can cause economic damages summing up to the Billion-Euro range. As evident from the past, aviation shows vulnerability with regard to natural hazards. Safe flight operations, air traffic management and air traffic control is a shared responsibility of EUROCONTROL, national authorities, airlines and pilots. All stakeholders have one common goal, namely to warrant and maintain the safety of flight crews and passengers. Currently, however, there is a significant gap in the Europe-wide availability of real time hazard measurement and monitoring information for airborne hazards describing "what, where, how much" in 3 dimensions, combined with a near-real-time European data analysis and assimilation system. This gap creates circumstances where various stakeholders in the system may base their decisions on different data and information. The H-2020 project EUNADICS-AV ("European Natural Disaster Coordination and Information System for Aviation"), started in October 2016, intends to close this gap in data and information availability, enabling all stakeholders in the aviation system to obtain fast, coherent and consistent information. The project intends to combine and harmonize data from satellite earth observation, ground based and airborne platforms, and to integrate them into state-of-the art data assimilation and analysis systems. Besides operational data sources, data from the research community are integrated as well. Hazards considered in the project include volcano eruptions, nuclear accidents and events, and forest fires. The availability of consistent and coherent data analysis fields based on all available measurements will greatly enhances our capability to respond to disasters effectively and efficiently, minimizing system downtimes and thus economic damage while maintaining the safety of millions of passengers.

  9. AV e attività di eccellenza. Nuove opportunità localizzative nel sistema Roma-Napoli

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2008-06-01

    Full Text Available Il contributo propone una lettura delle possibili influenze della realizzazione delle reti AV sulla localizzazione/distribuzione di attività di eccellenza, quali attività direzionali, di management, di servizio alle imprese e alla pubblica amministrazione, con specifico riferimento alla tratta AV Roma-Napoli. A partire da una caratterizzazione delle attività di eccellenza, se ne evidenzia anzitutto la spiccata tendenza alla concentrazione urbana, la dipendenza da efficaci connessioni sia immateriali che materiali e la rilevanza assunta dalla variabile temporale nelle scelte localizzative (Sassen, 2001. Quindi, in riferimento ad alcune esperienze europee, si esaminano i principali effetti, in termini di attrazione/concentrazione di tali attività, connessi alla realizzazione delle reti AV (Sands 1993; Vickerman e Ulied, 2006; Gemeente Amsterdam, 2007. Sulla base di tali considerazioni e tenendo conto delle più recenti definizioni e metodi di misura dell’accessibilità (Axhausen et al. 2006; Spiekermann, Wegener, 2005, lo studio propone un indicatore di “accessibilità” finalizzato ad individuare e graduare, in ragione dei livelli di accessibilità, un sistema di luoghi urbani interconnessi mediante reti su ferro (AV e reti metropolitane e regionali dai quali le attività di eccellenza potranno massimizzare il proprio bacino di utenza. L’individuazione di un sistema di luoghi urbani a diverso grado di accessibilità consente di evidenziare le numerose opportunità per la localizzazione di attività di eccellenza che si dischiudono a seguito della riduzione dei tempi di spostamento consentita dalle reti AV. In tal senso, l’indicatore proposto può costituire un utile supporto alle decisioni sia per l’attore pubblico consentendo di governare e orientare i processi di trasformazione conseguenti alla realizzazione della rete AV, estendendone i benefici dalle aree di stazione a più ampie porzioni urbane sia per l’investitore privato

  10. Inläsning av match- och dragningsinformation med användning av node.js : Ett arbete utfört vid företaget Svenska spel

    OpenAIRE

    Olsson, Rasmus; Ramadanovic, Alen

    2013-01-01

    Detta examensarbete har genomförts hos det statliga spelföretaget Svenska Spel i Sundbyberg. Svenska Spel har övervägt att använda sig av en ny plattform, Node.js, för att utveckla sina läsmoduler som läser match- och dragningsinformation. Idag används läsmoduler implementerade i programmeringsspråken C# och C för detta ändamål. Svenska Spel vill nu ha en utvärdering av hur lämpligt det är för dem att använda Node.js implementerade läsmoduler. Målet med detta examensarbete har varit att under...

  11. Framgångsfaktorer och barriärer vid integrering av klimatanpassning i  kommunal RSA : En undersökning av Värmlands småkommuner

    OpenAIRE

    Davidsson, Åsa

    2016-01-01

    Att klimatet förändras är konstaterat, skulle utsläppen av växthusgaser kraftigt minskas kan de påbörjade klimatförändringarna ändå inte helt förhindras. Förändringarna innebär att extremväder kommer inträffa oftare men med geografiska skillnader. Till seklets slut väntas i Värmland exempelvis nuvarande tioårsregn istället inträffa var femte år. Vänern kommer i och med detta utgöra en av de största översvämningsriskerna. Hur dessa förändringar påverkar samhället varierar beroende på samhället...

  12. Novel modes and adaptive block scanning order for intra prediction in AV1

    Science.gov (United States)

    Hadar, Ofer; Shleifer, Ariel; Mukherjee, Debargha; Joshi, Urvang; Mazar, Itai; Yuzvinsky, Michael; Tavor, Nitzan; Itzhak, Nati; Birman, Raz

    2017-09-01

    The demand for streaming video content is on the rise and growing exponentially. Networks bandwidth is very costly and therefore there is a constant effort to improve video compression rates and enable the sending of reduced data volumes while retaining quality of experience (QoE). One basic feature that utilizes the spatial correlation of pixels for video compression is Intra-Prediction, which determines the codec's compression efficiency. Intra prediction enables significant reduction of the Intra-Frame (I frame) size and, therefore, contributes to efficient exploitation of bandwidth. In this presentation, we propose new Intra-Prediction algorithms that improve the AV1 prediction model and provide better compression ratios. Two (2) types of methods are considered: )1( New scanning order method that maximizes spatial correlation in order to reduce prediction error; and )2( New Intra-Prediction modes implementation in AVI. Modern video coding standards, including AVI codec, utilize fixed scan orders in processing blocks during intra coding. The fixed scan orders typically result in residual blocks with high prediction error mainly in blocks with edges. This means that the fixed scan orders cannot fully exploit the content-adaptive spatial correlations between adjacent blocks, thus the bitrate after compression tends to be large. To reduce the bitrate induced by inaccurate intra prediction, the proposed approach adaptively chooses the scanning order of blocks according to criteria of firstly predicting blocks with maximum number of surrounding, already Inter-Predicted blocks. Using the modified scanning order method and the new modes has reduced the MSE by up to five (5) times when compared to conventional TM mode / Raster scan and up to two (2) times when compared to conventional CALIC mode / Raster scan, depending on the image characteristics (which determines the percentage of blocks predicted with Inter-Prediction, which in turn impacts the efficiency of the new

  13. Bibliografie a automatizace knihovnických procesů v Archeologickém ústavu AV ČR Praha

    Czech Academy of Sciences Publication Activity Database

    Ochrana, František

    57, 4 (2005), s. 810-811 ISSN 0323-1267 R&D Projects: GA AV ČR(CZ) 1ET200020405 Institutional research plan: CEZ:AV0Z80020508 Keywords : bibliography * automatization * librarianship Subject RIV: AF - Documentation, Librarianship , Information Studies

  14. 77 FR 1667 - Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, Respondent...

    Science.gov (United States)

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil... a last known address of Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, and when...

  15. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case.

    Science.gov (United States)

    Marquié, Marta; Verwer, Eline E; Meltzer, Avery C; Kim, Sally Ji Who; Agüero, Cinthya; Gonzalez, Jose; Makaretz, Sara J; Siao Tick Chong, Michael; Ramanan, Prianca; Amaral, Ana C; Normandin, Marc D; Vanderburg, Charles R; Gomperts, Stephen N; Johnson, Keith A; Frosch, Matthew P; Gómez-Isla, Teresa

    2017-10-19

    [F-18]-AV-1451 is a novel positron emission tomography (PET) tracer with high affinity to neurofibrillary tau pathology in Alzheimer's disease (AD). PET studies have shown increased tracer retention in patients clinically diagnosed with dementia of AD type and mild cognitive impairment in regions that are known to contain tau lesions. In vivo uptake has also consistently been observed in midbrain, basal ganglia and choroid plexus in elderly individuals regardless of their clinical diagnosis, including clinically normal whose brains are not expected to harbor tau pathology in those areas. We and others have shown that [F-18]-AV-1451 exhibits off-target binding to neuromelanin, melanin and blood products on postmortem material; and this is important for the correct interpretation of PET images. In the present study, we further investigated [F-18]-AV-1451 off-target binding in the first autopsy-confirmed Parkinson's disease (PD) subject who underwent antemortem PET imaging. The PET scan showed elevated [F-18]-AV-1451 retention predominantly in inferior temporal cortex, basal ganglia, midbrain and choroid plexus. Neuropathologic examination confirmed the PD diagnosis. Phosphor screen and high resolution autoradiography failed to show detectable [F-18]-AV-1451 binding in multiple brain regions examined with the exception of neuromelanin-containing neurons in the substantia nigra, leptomeningeal melanocytes adjacent to ventricles and midbrain, and microhemorrhages in the occipital cortex (all reflecting off-target binding), in addition to incidental age-related neurofibrillary tangles in the entorhinal cortex. Additional legacy postmortem brain samples containing basal ganglia, choroid plexus, and parenchymal hemorrhages from 20 subjects with various neuropathologic diagnoses were also included in the autoradiography experiments to better understand what [F-18]-AV-1451 in vivo positivity in those regions means. No detectable [F-18]-AV-1451 autoradiographic binding was

  16. Digital kommunikation : En undersökning av bruket och attityder till emojis och smileys i elektronisk konversation

    OpenAIRE

    Leijonberg, Lisa

    2017-01-01

    Emojis har fått en allt större roll i elektronisk konversation. Den här studien undersöker bruket av emojis och smileys i sms- och chattspråk samt vad det finns för attityder till dessa. Detta undersöks genom en enkätundersökning som har distribuerats på sociala medier. Under-sökningen är uppdelad i två delar, där den första delen syftar till att kartlägga bruket av emojis och smileys utifrån ålder, utbildning och kön och den andra delen syftar till att undersöka attityder till användningen a...

  17. Bilderboken ur ett genusperspektiv : En bilderboksanalys av tre svenska böcker som utmanar stereotypa könsroller

    OpenAIRE

    Malmqvist, Hanna

    2015-01-01

    Syftet med denna studie är att se hur några bilderböcker utmanar de stereotypa könsrollerna. Jag kommer att granska hur pojkar och flickor framställs ur ett genusperspektiv och även titta på hur text och bild kompletterar varandra, med hjälp av Nikolajevas (2000) analysmodell för bilderböcker. Jag har valt att analysera tre stycken böcker och två av dessa har pojkar som huvudkaraktärer och en har en flicka som huvudkaraktär. Med den medvetenhet man har idag kring genus så kan dessa böcker var...

  18. Erfarenhetens och reflektionens betydelse för lärandet av molekylära processer

    Directory of Open Access Journals (Sweden)

    Caroline Larsson

    2015-06-01

    Full Text Available Lärande om molekylära processer kan innebära vissa svårigheter dels för att dessa processer inte går att direkt erfara och dels för att de är dynamiska i sin natur. Ett sätt att överbrygga problematiken är att använda sig av olika representationer, vilket i sig medför ytterligare utmaningar. Studenters förkunskaper och intuitiva idéer som härstammar från vardagserfarenheter kan också ge upphov till svårigheter i meningsskapandet. Syftet med denna artikel är att diskutera erfarenhetens och reflektionens betydelse för undervisning och lärande med representationer av molekylära fenomen i högre utbildning. I artikeln presenteras empiriska resultat från forskningsstudier som ligger till grund för de idéer och resonemang som förs fram. Vi presenterar två exempel där studenter arbetar i grupp med representationer av de molekylära processerna ATP-syntes och självassociation. Grunden för grupparbetet och meningsskapandet är fokuserade frågor där egna tankar och idéer får ta plats. Reflektionen i grupparbetet ger också studenterna möjligheter att generalisera sina erfarenheter (abstrakt tänkande och underlättar förståelsen av tröskelbegrepp.

  19. Planeamiento estratégico del sector avícola cárnico en el Perú

    OpenAIRE

    Becerra Hernández, María Angelita; Llosa Rubio, Giulliana Fiorella; Paico Casavilca, Javier Moisés

    2015-01-01

    El presente plan estratégico está basado en el Modelo Secuencial de Planeación Estratégica de D’Alessio (2013), y ha sido desarrollado con el fin de elevar la competitividad del sector avícola cárnico en el Perú. Para ello, se hizo un profundo análisis in Tesis

  20. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    Science.gov (United States)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  1. Adaptive CRT in patients with normal AV conduction and left bundle branch block: Does QRS duration matter?

    Science.gov (United States)

    Yamasaki, Hiro; Lustgarten, Daniel; Cerkvenik, Jeffrey; Birnie, David; Gasparini, Maurizio; Lee, Kathy Lia-Fun; Sekiguchi, Yukio; Varma, Niraj; Lemke, Bernd; Starling, Randall C; Aonuma, Kazutaka

    2017-08-01

    Adaptive cardiac resynchronization therapy (aCRT) is a dynamic optimization algorithm which paces only the left ventricle (LV) when atrio-ventricular (AV) conduction is normal, thus reducing right ventricular (RV) pacing. However, the impact of QRS duration on aCRT efficacy remains uncertain. We examined whether QRS duration impacts aCRT effectiveness in patients with left bundle branch block (LBBB) and preserved AV conduction. Randomized patients in the Adaptive CRT trial, which enrolled NYHA III/IV patients, were used in this analysis. Patients were randomized to receive aCRT or echo-optimized bi-ventricular CRT (control arm). Endpoints for this analysis were clinical composite score (CCS) at 6months post-implant and time to first heart failure (HF) hospitalization or death. Among the 199 patients with LBBB and normal AV intervals at baseline, 80 patients (40%) had a baseline moderately wide QRS of 120-150ms. In this subgroup, a greater proportion of aCRT patients had an improved CCS (79% vs. 50%) at 6months compared to the control group (p=0.03). There was also a trend toward a lower risk of death or HF hospitalization (hazard ratio: 0.53; 95% CI: 0.24-1.15; p=0.10) in the moderately wide QRS subgroup with aCRT compared to the control arm. In the wide QRS subgroup, the efficacy was comparable in both treatment arms. Adaptive CRT was associated with improved patient outcomes over echo-optimized bi-ventricular CRT in patients with preserved AV conduction, LBBB, and moderately wide QRS. The adaptive cardiac resynchronization therapy trial (ClinicalTrials.gov Identifier: NCT00980057) was sponsored by Medtronic plc, Mounds View, MN. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Overvåkning av miljøgifter i luft og nedbør, årsrapport 2016

    OpenAIRE

    Nizzetto, Pernilla Bohlin; Aas, Wenche; Warner, Nicholas Alexander

    2017-01-01

    This monitoring report presents 2016 data and time-trends for the Norwegian programme for long-range atmospheric transported contaminants. The results cover 122 organic compounds and 11 heavy metals. The organic contaminants includes regulated persistent organic pollutants (POPs) as well POP-like contaminants not yet subjected to international regulations. Overvåkning av miljøgifter i luft og nedbør, årsrapport 2016

  3. Med fingrarna på kontrabasen : En kvalitativ studie av tre kontrabasisters syn på sin teknik

    OpenAIRE

    Beyer, Hannes

    2014-01-01

    Studien syftar till att utifrån hermeneutiskt perspektiv, utforska hur tre kontrabasister har kommit fram till just sitt sätt att tekniskt ta sig an instrumentet samt vilken funktion dessa kontrabasister anser att deras teknik har. Studiens datamaterial består av kvalitativa samtalsintervjuer med tre professionella kontrabasister som arbetar inom ett flertal genrer. I resultatavsnittet beskrivs respektive respondents tekniska förhållningsätt till kontrabasen utifrån tre tematiska metaforer: E...

  4. Industrias Bachoco: estrategias de localización y competitividad ante el nuevo escenario avícola

    Directory of Open Access Journals (Sweden)

    María del Carmen Hernández Moreno

    2009-01-01

    Full Text Available Los cambios sustantivos en el sistema agroalimentario mexicano han impulsado a las empresas a aplicar estrategias que les permitan funcionar en un contexto cada vez más competitivo, complejo e incierto. En el ramo avícola, Industrias Bachoco ha logrado posicionarse como líder nacional, a pesar de las presiones de la apertura comercial y de la competencia interna de dos de los mayores consorcios avícolas transnacionales. El presente artículo destaca los resultados obtenidos por esta empresa a partir de su estrategia de desplazamiento por la república mexicana. Desde la perspectiva de la teoría de la localización y de la nueva geografía económica, se plantea la hipótesis de que tal estrategia le ha permitido a Bachoco sumar ventajas comparativas regionales y le ha conferido la capacidad de suministrar una oferta adaptada a las costumbres y tradiciones de cada mercado regional, que no ha sido igualada por ninguna de sus competidoras. Se concluye que la apertura total inminente del mercado avícola mexicano inducirá al consorcio a acelerar su actualización, para estar a tono y competir con las empresas internacionales.

  5. DNS reparācijas veicinātāja AV-153-Na mijiedarbība ar DNS

    OpenAIRE

    Ļeonova, Elīna

    2013-01-01

    Daudzu savienojumu spēja tieši mijiedarboties ar DNS spirāli liecina par to mutagēnām un kancerogēnām īpašībām.Tomēr,pedējos gados, parādījās daudzi ziņojumi,par tiešo antimutagēnu mijiedarbību ar DNS,interkalējot un dažādveida piesaistoties DNS rievām. Nesen ir pieradīts, ka AV -153 ir antimutagēns un reparācijas veicinātājs. Darba mērķis bija izpētīt 1,4 dihidropiridīna atvasinājuma AV -153 mijiedarbību ar DNS ka arī parbaudīt AV-153 ietekmi uz DNS pasargāšanu no H2O2 iedarbības un DNS pārr...

  6. Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats

    Energy Technology Data Exchange (ETDEWEB)

    Tsao, H.-H. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Lin, K.-J. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Department of Nuclear Medicine, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan (China); Juang, J.-H. [Division of Endocrinology and Metabolism, Chung Gung University and Chung Gung Memorial Hospital, Taoyuan, Taiwan (China); Skovronsky, Daniel M. [Avid Radiopharmaceuticals, Philadelphia, PA (United States); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Yen, T.-C. [Department of Nuclear Medicine, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan (China); Wey, S.-P. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Kung, M.-P. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States)], E-mail: kungmp@sunmac.spect.upenn.edu

    2010-05-15

    The vesicular monoamine transporter type 2 (VMAT2) is highly expressed in pancreatic {beta}-cells and thus has been proposed to be a potential target for measuring {beta}-cell mass (BCM) by molecular imaging. C-11- and F-18-labeled tetrabenazine derivatives targeting VMAT2 have shown some promising results as potential biomarkers for BCM. In the present study, we examined the binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine ([{sup 18}F]AV-133), a potential PET tracer for BCM imaging, in rat pancreas and rat brain. Methods: Pancreatic exocrine cells and pancreatic islet cells were isolated and purified from Sprague-Dawley rats. Membrane homogenates, prepared from both pancreatic exocrine and islet cells as well as from brain striatum and hypothalamus regions, were used for in vitro binding studies. In vitro and ex vivo autoradiography studies with [{sup 18}F]AV-133 were performed on rat brain and rat pancreas sections. Immunohistochemistry studies were performed to confirm the distribution of VMAT2 on islet {beta}-cells. Results: Excellent binding affinities of [{sup 18}F]AV-133 were observed in rat striatum and hypothalamus homogenates with K{sub d} values of 0.19 and 0.25 nM, respectively. In contrast to single-site binding observed in rat striatum homogenates, rat islet cell homogenates showed two saturable binding sites (site A: K{sub d}=6.76 nM, B{sub max}=60 fmol/mg protein; site B: K{sub d}=241 nM, B{sub max}=1500 fmol/mg protein). Rat exocrine pancreas homogenates showed only a single low-affinity binding site (K{sub d}=209 nM), which was similar to site B in islet cells. In vitro autoradiography of [{sup 18}F]AV-133 using frozen sections of rat pancreas showed specific labeling of islets, as evidenced by co-localization with anti-insulin antibody. Ex vivo VMAT2 pancreatic autoradiography in the rat, however, was not successful, in contrast to the excellent ex vivo autoradiography of VMAT2 binding sites in the brain. In vivo/ex vivo islet

  7. Kinetic Modeling of the Tau PET Tracer18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects.

    Science.gov (United States)

    Barret, Olivier; Alagille, David; Sanabria, Sandra; Comley, Robert A; Weimer, Robby M; Borroni, Edilio; Mintun, Mark; Seneca, Nicholas; Papin, Caroline; Morley, Thomas; Marek, Ken; Seibyl, John P; Tamagnan, Gilles D; Jennings, Danna

    2017-07-01

    18 F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The objective of this study was to evaluate 18 F-AV-1451 binding with full kinetic analysis using a metabolite-corrected arterial input function and to compare parameters derived from kinetic analysis with SUV ratio (SUVR) calculated over different imaging time intervals. Methods: 18 F-AV-1451 PET brain imaging was completed in 16 subjects: 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV), and 8 Alzheimer disease (AD) subjects. Subjects were imaged for 3.5 h, with arterial blood samples obtained throughout. PET data were analyzed using plasma and reference tissue-based methods to estimate the distribution volume, binding potential (BP ND ), and SUVR. BP ND and SUVR were calculated using the cerebellar cortex as a reference region and were compared across the different methods and across the 3 groups (YHV, AHV, and AD). Results: AD demonstrated increased 18 F-AV-1451 retention compared with YHV and AHV based on both invasive and noninvasive analyses in cortical regions in which paired helical filament tau accumulation is expected in AD. A correlation of R 2 > 0.93 was found between BP ND (130 min) and SUVR-1 at all time intervals. Cortical SUVR curves reached a relative plateau around 1.0-1.2 for YHV and AHV by approximately 50 min, but increased in AD by up to approximately 20% at 110-130 min and approximately 30% at 160-180 min relative to 80-100 min. Distribution volume (130 min) was lower by 30%-35% in the YHV than AHV. Conclusion: Our data suggest that although 18 F-AV-1451 SUVR curves do not reach a plateau and are still increasing in AD, an SUVR calculated over an imaging window of 80-100 min (as currently used in clinical studies) provides estimates of paired helical filament tau burden in good correlation with BP ND , whereas SUVR sensitivity to regional cerebral blood changes needs further investigation. © 2017 by the Society of Nuclear Medicine and

  8. Biodigestão anaeróbia de efluente de abatedouro avícola

    Directory of Open Access Journals (Sweden)

    Arley Borges de Morais Oliveira

    2011-12-01

    Full Text Available Objetivou-se, com este trabalho, avaliar o processo de biodigestão anaeróbia no tratamento de efluentes de abatedouro avícola, considerando-se os TRH de 7, 14 e 21 dias, além da adição de enzima lipolítica aos substratos, nas concentrações de 0; 0,5; 1,0 e 1,5 g L-1 de carga adicionada aos biodigestores. A influência dos TRH e da adição de enzima lipolítica aos substratos foi avaliada por meio das produções de biogás e CH4, dos potenciais de produção por DQO, adicionada e removida, bem como pelas reduções dos teores de DQO, concentrações de N, P e K e dos valores de pH. Os resultados obtidos demonstraram que houve influência dos TRH (em que o TRH 7 expressou os melhores resultados, para produção semanal média de biogás, com 40,7 L, e CH4, com 32,2 L e das concentrações de enzimas, com maiores valores de produção para os tratamentos 1,0 (24,6 L e 1,5 g L-1 (26,2 L, que não diferiram entre si. As concentrações de enzimas de 1,0 e 1,5 g L-1 apresentaram maiores potenciais de produção de biogás (1,1 e 1,1 L g-1 de DQO adicionada, respectivamente e metano (0,9 e 0,8 L g¹ de DQO adicionada, respectivamente, quando comparadas com as da 0,5 g L-1 (0,8 e 0,7 L g-1 biogás e CH4, respectivamente e 0 (0,7 e 0,5 L g-1 biogás e CH4, respectivamente. As maiores remoções de DQO foram alcançadas nas concentrações de 0,5 g L-1 (83,3% e TRH de 21 dias (74,4%. Contudo, para que haja maior eficiência na reciclagem energética, recomenda-se a utilização de concentrações de 1,0 g L-1 de efluente e tempo de retenção hidráulica de 7 dias.

  9. Korleis sjukepleievitskap materialiserer seg i lys av historisk oppkomst – kunnskapsgenerering i spenningsfeltet mellom klinikk og akademia

    Directory of Open Access Journals (Sweden)

    Wenche Sortvik

    2016-06-01

    Full Text Available How nursing science materializes related to historical origin – knowledge in the field of tension between the clinic and academia   The focus of this paper is on the scientific development in nursing, and is based on an analysis of master-thesis in nursing science at the University of Bergen in the period 2005-2010 when the master title came to Norway (Sortvik 2011. The aim of this paper is on what focus a new scientific discipline as nursing science has developed through the thesis, and how it constitutes during a certain amount of time. The article starts with a presentation of themes and the basis of recognition. Then philosophy of science and methodologies that are the dominant tendencies will be discussed related to the historical origin of nursing science at the University of Bergen. The empirical theoretical and methodological approach is based upon the theory of the French sociologist Pierre Bourdieu about understanding current practices in light of historical origin. Results: Majority uses qualitative method (71.4%, and is using phenomenological and hermeneutical approaches. The quantitative tasks (26.2% are mainly anchored in medical terminology and are using medical statistics. Issues are mainly from the nurses own practices and practical utility are emphasized. Only one work is using mixed methods. Questions that will be discussed are why these master-thesis materialize in the way they do, and what kind of factors that influence opportunities and choices in nursing science? Artikkelen omhandlar sjukepleievitskapleg kunnskapsproduksjon, og er basert på ein analyse av mastergradsoppgåver i sjukepleievitskap ved Universitetet i Bergen frå perioden 2005-2010 (Sortvik 2011. Spørsmål som belysast er korleis eit ungt vitskapsfag som sjukepleievitskap gjennom eit tidsrom konstituerer seg som produsent av ny kunnskap. Artikkelen startar med presentasjon av erkjenningsgrunnlaget og tematikkane i mastergradsoppgåvene. Deretter

  10. Preparation and stability of ethanol-free solution of [18F]florbetapir ([18F]AV-45) for positron emission tomography amyloid imaging.

    Science.gov (United States)

    Hayashi, Kazutaka; Tachibana, Akiko; Tazawa, Shusaku; Mizukawa, Yosuke; Osaki, Katsuhiko; Morimoto, Yoko; Zochi, Riyo; Kurahashi, Masahiro; Aki, Hatsumi; Takahashi, Kazuhiro

    2013-05-15

    We have developed an ethanol-free formulation method of [(18) F]florbetapir ([(1) (8) F]AV-45) using a commercially available automated JFE multi-purpose synthesizer. We have also evaluated the radiochemical stability in an ethanol-free solution of [(18) F]AV-45 under visible light irradiation and dark conditions by comparison with a conventional 10% ethanol solution of [(18) F]AV-45. [(18) F]AV-45 was obtained with a radiochemical yield of 55.1 ± 2.2% (decay-corrected to end of bombardment), specific activity of 591.6 ± 90.3 GBq/µmol and radiochemical purity of >99% within a total synthesis time of about 73 min. The radiochemical purity of [(18) F]AV-45 formulated by dissolving the ethanol-free solution was found to decrease as a function of the period of exposure to visible light. In contrast, the visible light photolysis could be suppressed by adding 10% ethanol to the formulation or by avoiding exposure to visible light. In the radiosynthesis of [(18) F]AV-45 formulated by dissolving the ethanol-free solution, [(18) F]AV-45 could be obtained with high radiochemical purity and high stability by avoiding exposure to visible light. Copyright © 2013 John Wiley & Sons, Ltd.

  11. Circulating Fibroblast Growth Factor-23 Level and Paraoxonase-1 Lactonase Activity in Chronic Hemodialysis Patients: Their Impact on the Incidence of Native AV Fistula Thrombosis.

    Science.gov (United States)

    Zohny, Samir F; El-Fattah, Mahmoud Abd; Khan, Jalaluddin A

    2016-10-14

    Thrombosis of native arteriovenous (AV) fistula is an important cause of complications in hemodialysis (HD) patients. The purpose of this study was to investigate the usefulness of measuring circulating fibroblast growth factor-23 (FGF-23) level and paraoxonase-1 (PON1) lactonase activity as potential predictors of native AV fistula thrombosis in chronic HD patients. This study included 83 HD patients (48 with thrombosed and 35 with non-thrombosed native AV fistulas) and 38 healthy volunteers. Serum FGF-23 level was measured using the ELISA technique, while serum PON1 lactonase activity was measured spectrophotometrically using gamma-thiobutyrolactone as a substrate. FGF-23 was significantly increased while PON1 lactonase was markedly decreased in both thrombosed and non-thrombosed HD patients compared with controls (P AV fistulas compared with HD patients with non-thrombosed native AV fistulas (P = 0.001 and 0.002, respectively). A significant negative correlation was found between FGF-23 and PON1 lactonase in HD patients with thrombosed native AV fistulas (r = -0.342, P = 0.017). This study shows a potential value of FGF-23 and PON1 lactonase as predictors of native AV fistula thrombosis in HD patients.

  12. Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.

    Science.gov (United States)

    Jang, Young Kyoung; Lyoo, Chul Hyoung; Park, Seongbeom; Oh, Seung Jun; Cho, Hanna; Oh, Minyoung; Ryu, Young Hoon; Choi, Jae Yong; Rabinovici, Gil D; Kim, Hee Jin; Moon, Seung Hwan; Jang, Hyemin; Lee, Jin San; Jagust, William J; Na, Duk L; Kim, Jae Seung; Seo, Sang Won

    2018-03-01

    Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer's disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [ 18 F] AV-1451 and [ 18 F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer's disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer's disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [ 18 F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer's disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. AV-1451 is more sensitive and specific to Alzheimer's disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.

  13. The Pattern of Brain Amyloid Load in Posterior Cortical Atrophy Using 18F-AV45: Is Amyloid the Principal Actor in the Disease

    Directory of Open Access Journals (Sweden)

    Emilie Beaufils

    2014-11-01

    Full Text Available Background: Posterior cortical atrophy (PCA is characterized by progressive higher-order visuoperceptual dysfunction and praxis declines. This syndrome is related to a number of underlying diseases, including, in most cases, Alzheimer's disease (AD. The aim of this study was to compare the amyloid load with 18F-AV45 positron emission tomography (PET between PCA and AD subjects. Methods: We performed 18F-AV45 PET, cerebrospinal fluid (CSF biomarker analysis and a neuropsychological assessment in 11 PCA patients and 12 AD patients. Results: The global and regional 18F-AV45 uptake was similar in the PCA and AD groups. No significant correlation was observed between global 18F-AV45 uptake and CSF biomarkers or between regional 18F-AV45 uptake and cognitive and affective symptoms. Conclusion: This 18F-AV45 PET amyloid imaging study showed no specific regional pattern of cortical 18F-AV45 binding in PCA patients. These results confirm that a distinct clinical phenotype in amnestic AD and PCA is not related to amyloid distribution.

  14. The Pattern of Brain Amyloid Load in Posterior Cortical Atrophy Using (18)F-AV45: Is Amyloid the Principal Actor in the Disease?

    Science.gov (United States)

    Beaufils, Emilie; Ribeiro, Maria Joao; Vierron, Emilie; Vercouillie, Johnny; Dufour-Rainfray, Diane; Cottier, Jean-Philippe; Camus, Vincent; Mondon, Karl; Guilloteau, Denis; Hommet, Caroline

    2014-09-01

    Posterior cortical atrophy (PCA) is characterized by progressive higher-order visuoperceptual dysfunction and praxis declines. This syndrome is related to a number of underlying diseases, including, in most cases, Alzheimer's disease (AD). The aim of this study was to compare the amyloid load with (18)F-AV45 positron emission tomography (PET) between PCA and AD subjects. We performed (18)F-AV45 PET, cerebrospinal fluid (CSF) biomarker analysis and a neuropsychological assessment in 11 PCA patients and 12 AD patients. The global and regional (18)F-AV45 uptake was similar in the PCA and AD groups. No significant correlation was observed between global (18)F-AV45 uptake and CSF biomarkers or between regional (18)F-AV45 uptake and cognitive and affective symptoms. This (18)F-AV45 PET amyloid imaging study showed no specific regional pattern of cortical (18)F-AV45 binding in PCA patients. These results confirm that a distinct clinical phenotype in amnestic AD and PCA is not related to amyloid distribution.

  15. Multimodal correlation of dynamic [{sup 18}F]-AV-1451 perfusion PET and neuronal hypometabolism in [{sup 18}F]-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Hammes, Jochen; Leuwer, Isabel [University Hospital Cologne, Multimodal Neuroimaging Group, Department of Nuclear Medicine, Cologne (Germany); Bischof, Gerard N. [University Hospital Cologne, Multimodal Neuroimaging Group, Department of Nuclear Medicine, Cologne (Germany); INM-3, Research Center Juelich, Juelich (Germany); Drzezga, Alexander [University Hospital Cologne, Multimodal Neuroimaging Group, Department of Nuclear Medicine, Cologne (Germany); German Center for Neurodegeneration (DZNE), Berlin (Germany); Eimeren, Thilo van [University Hospital Cologne, Multimodal Neuroimaging Group, Department of Nuclear Medicine, Cologne (Germany); INM-3, Research Center Juelich, Juelich (Germany); German Center for Neurodegeneration (DZNE), Berlin (Germany)

    2017-12-15

    Cerebral glucose metabolism measured with [18F]-FDG PET is a well established marker of neuronal dysfunction in neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET is currently under evaluation and shows promising results. Here, we assess the feasibility of early perfusion imaging with AV-1451 as a substite for FDG PET in assessing neuronal injury. Twenty patients with suspected neurodegeneration underwent FDG and early phase AV-1451 PET imaging. Ten one-minute timeframes were acquired after application of 200 MBq AV-1451. FDG images were acquired on a different date according to clinical protocol. Early AV-1451 timeframes were coregistered to individual FDG-scans and spatially normalized. Voxel-wise intermodal correlations were calculated on within-subject level for every possible time window. The window with highest pooled correlation was considered optimal. Z-transformed deviation maps (ZMs) were created from both FDG and early AV-1451 images, comparing against FDG images of healthy controls. Regional patterns and extent of perfusion deficits were highly comparable to metabolic deficits. Best results were observed in a time window from 60 to 360 s (r = 0.86). Correlation strength ranged from r = 0.96 (subcortical gray matter) to 0.83 (frontal lobe) in regional analysis. ZMs of early AV-1451 and FDG images were highly similar. Perfusion imaging with AV-1451 is a valid biomarker for assessment of neuronal dysfunction in neurodegenerative diseases. Radiation exposure and complexity of the diagnostic workup could be reduced significantly by routine acquisition of early AV-1451 images, sparing additional FDG PET. (orig.)

  16. Mätosäkerhet vid kalibrering av referensutrustning för blodtrycksmätning : En modell för framtagning av mätosäkerhet för referensmanometer WA 767

    OpenAIRE

    Patzauer, Rebecka; Wessel, Elin

    2016-01-01

    Avdelningen för Medicinsk teknik på Akademiska sjukhuset har uppdaterat befintliga kalibreringsprotokoll för Welch Allyn 767 som används som referensmanometer vid kalibrering av blodtrycksmätare. I protokollet ska det enligt ISO 9001 och ISO 13485 ingå att vid varje kalibreringspunkt ange mätosäkerheten.  Rutiner kring detta var inte definierade. En modell för att ta fram mätosäkerhet utformades utifrån standardiserade metoder från “Guide to the expression of uncertainty in measurement” och a...

  17. ”Det må vi jo være ærlige på…” : en kvalitativ studie av barneverntjenestens oppfølging av foreldre etter en omsorgsovertakelse

    OpenAIRE

    Tangnes, Silje Njarde

    2011-01-01

    Master i sosialt arbeid Foreldre som blir fratatt omsorgen for sine barn har i dag en lovfestet rett til oppfølging. Det viser seg likevel at denne oppfølginga er mangelfull, tilfeldig og lite systematisert. Problemstilling i denne oppgaven tar utgangspunkt i hva som fremmer og hemmer oppfølgingen av foreldrene. Seks saksbehandlere er intervjuet for å belyse dette tema. Ulike forhold i barneverntjenesten er undersøkt for å se om det er strukturelle forhold eller den individuelle saksbeh...

  18. Redovisning är sällan ren och aldrig enkel : En studie om svårigheter och komplexitet vid framtagning av IFRS 15

    OpenAIRE

    Melin, Linnea; Stenberg, Frida

    2015-01-01

    Bakgrund Som en följd av den ökade globaliseringen strävar normgivare ständigt efter en harmonisering av internationella redovisningsstandarder. I maj 2014 publicerade normgivaren IASB (International Accounting Standards Board) en ny standard för intäktsredovisning – IFRS 15. Vid framtagning av nya redovisningsstandarder ska normgivare utgå från en generell föreställningsram. Det faktum att kapitalmarknadens aktörer under de senaste åren har fått betydligt mer inflytande skulle kunna påverka ...

  19. ARTISTS - huvudgator för alla : Vägledning för planerare och beslutsfattare vid utformning och ombyggnad av huvudgator

    OpenAIRE

    Svensson, Åse; Marshall, Stephen; Jones, Peter; Hydén, Christer; Draskoczy, Magda; Papaioannou, Panos; Thomsen, Hytte; Boujenko, Natalya

    2004-01-01

    Konventionella guider för utformning och förvaltning av trafikleder och stadsgator har vanligtvis inriktats antingen mot huvudtrafikleder eller mot lokala stadsgator. Det är för närvarande brist på ett tydligt och konsekvent angreppssätt för arbetet med utformning av huvudgator där signifikant genomfartstrafik och lokala funktioner kombineras. Målet är att denna rapport ska avhjälpa den bristen genom att presentera riktlinjer för utformning och förvaltning av huvudgator – med människan i foku...

  20. Kreves det for mye av ledere? : en vandring gjennom Dantes Inferno med blikk på moderne krav til godt lederskap

    OpenAIRE

    Eikeset, Kjetil

    2009-01-01

    Oppgaven tar utgangspunkt i krav til godt lederskap i moderne teori, og er en undersøkelse av disse kravene med henblikk på psykologiske problemstillinger og idealer. Det blir gitt en oversikt over krav som stilles til ledere innenfor moderne ledelsesteori, og de grunnleggende eksistensielle problemstillingene som ligger implisitt i disse formelle kriteriene for godt lederskap. Oppgaven tydeliggjør problemer som oppstår i forlengelsen av teoretiske krav ved å se på ønskede konsekvenser av de ...

  1. Imaging of VMAT2 binding sites in the brain by (18)F-AV-133: the effect of a pseudo-carrier.

    Science.gov (United States)

    Zhu, Lin; Qiao, Hongwen; Lieberman, Brian P; Wu, Jingxiao; Liu, Yajing; Pan, Zhongyun; Ploessl, Karl; Choi, Seok Rye; Chan, Piu; Kung, Hank F

    2012-10-01

    Recently, 9-[(18)F]fluoropropyl-(+)-dihydrotetrabenazine ((18)F-AV-133) was reported as a new vesicular monoamine transporter (VMAT2) imaging agent for diagnosis of Parkinson's disease (PD). To shorten the preparation of (18)F-AV-133 and to make it more widely available, we evaluated a simple, rapid purification with a solid-phase extraction method (SPE) using an Oasis HLB cartridge instead of high pressure liquid chromatography (HPLC). The SPE method produced doses containing a pseudo-carrier, 9-hydroxypropyl-(+)-dihydrotetrabenazine (AV-149). To test the possible side effects of this pseudo-carrier, comparative dynamic PET scans of the brains of normal monkeys (2 each) and uni-laterally 6-OH-dopamine-lesioned PD monkeys (2 each) were performed using (18)F-AV-133 doses prepared by either SPE (containing pseudo-carrier) or HPLC (containing no pseudo-carrier). Autoradiographs of post mortem monkey brain sections were evaluated to confirm the relative (18)F-AV-133 uptake in the PD monkey brains and the effects of the pseudo-carrier on VMAT2 binding. The radiochemical purity of the (18)F-AV-133, whether prepared by SPE or by HPLC, was excellent (>99%). PET scans of normal and PD monkey brains showed an expected reduction of VMAT2 in the lesioned areas of the striatum. It was not affected by the presence of the pseudo-carrier, AV-149 (maximally 250 μg/dose). The reduced uptake in the striatum of the lesioned monkey brains was confirmed by autoradiography. Ex vivo inhibition studies of (18)F-AV-133 binding in rat brains, conducted with increasing amounts of AV-149, suggested that at the highest concentration (3.5mg/kg) the VMAT2 binding in the striatum was only moderately blocked (20% reduction). The pseudo-carrier, AV-149, did not affect the (18)F-AV-133/PET imaging of VMAT2 binding sites in normal or uni-laterally lesioned monkey brains. The new streamlined SPE purification method will enable (18)F-AV-133 to be widely available for routine clinical application in

  2. ”Varken E=mc2 eller Det förlorade paradiset rafsades ihop av en festprisse” : En kvalitativ studie om introvert beteende i skolan

    OpenAIRE

    Larsson, Sofie; Nordqvist, Micaela

    2015-01-01

    Denna studie syftar till att lyfta fram begreppet introvert i skolvärlden genom att undersöka hur introverta beteenden kan påverka elevers utbildning. Vi lyfter även fram lärares tillskrivande av introvert beteende. Vi utgår ifrån Jung och H.J. Eysencks definitioner av begreppet introvert samt tar upp olika beteendeteorier och perspektiv på introvert beteende för att kunna identifiera och analysera våra resultat. Studiens metod är en empirisk datainsamling i form av observationer och intervju...

  3. Hva er Digital Valuta? Hva slags formuerettslig produkt er digital valuta? Omfattes slike finansielle produkter av gjeldende finansreguleringer og hvordan burde de reguleres?

    OpenAIRE

    Heggen, Vilde Stuvøy

    2014-01-01

    Det er kanskje ingen overraskelse at man i internettalderen har funnet på en valuta som kun eksisterer på nett. Per i dag eksisterer det flere slike nettvalutaer, med varierende grad av oppslutning. Spørsmålet som stilles i oppgaven er hva slags formuerettslig objekt digital valuta er. Jeg regner digital valuta som alle valutaer som hovedsakelig er å finne på nett og som ikke utstedes av eller på vegne av en statsmakt. Definisjonen omfatter både kryptovalutaer som Bitcoin, som nok er mest kje...

  4. Modulation of Interleukin-8 and staphylococcal flora by Avène hydrotherapy in patients suffering from chronic inflammatory dermatoses.

    Science.gov (United States)

    Casas, C; Ribet, V; Alvarez-Georges, S; Sibaud, V; Guerrero, D; Schmitt, A-M; Redoulès, D

    2011-02-01

    A number of studies argue in favour of an important role of microbial colonization, in particular of Staphylococcus aureus, in triggering atopic dermatitis (AD) flare-up and psoriasis, in particular through the superantigenic properties of toxins generated by S. aureus. The aim of this study was to assess the efficacy of a 3-week Avène hydrotherapy on the skin surface of patients suffering from psoriasis or atopic dermatitis. Skin samples were taken from healthy subjects or atopic (n = 18) or psoriatic patients (n = 39) undergoing hydrotherapy at Avène at the beginning (D0) and the end of treatment (D18). The severity of the dermatosis was evaluated according to SCORing Atopic Dermatitis (SCORAD) or Psoriasis Area Severity Index (PASI) scores at D0 and D18. Marker of inflammation interleukin 8 (IL-8), S. aureus colonization (protein A) and enterotoxins were assessed in skin samples using RT-PCR. At D0, significant differences were observed between healthy subjects and atopic or psoriatic patients in all the parameters evaluated (IL-8, protein A). At the end of the hydrotherapy, a significant decrease in SCORAD was associated with a significant reduction of IL-8, S. aureus colonization and enterotoxin D in patients with atopic dermatitis. Similarly, a significant decrease in PASI was associated with a significant reduction of IL-8, S. aureus colonization and enterotoxin N in patients with psoriasis. This study demonstrates the positive effects of Avène hydrotherapy on the skin of patients suffering from chronic dermatosis, with decreased inflammation and reduced colonization by S. aureus. © 2010 The Authors. JEADV © 2010 European Academy of Dermatology and Venereology.

  5. FRA MODERNE SEKULARISERING TIL POSTMODERNE DESEKULARISERING : - en analyse av Peter L. Bergers teorier om sekularisering og pluralisering

    OpenAIRE

    Jørgensen, Flemming

    2003-01-01

    Utgangspunktet for denne oppgaven er den amerikanske sosiologen Peter L. Bergers bok The Sacred Canopy fra 1967 og hans artikkel The Desecularization of the World fra 1999. I Del 2 av The Sacred Canopy fremmet Berger sin opprinnelige sekulariseringsteori. Dette er en forholdsvis konvensjonell teori i den forstand at den ikke ligger langt unna datidens etablerte sosiologiske kunnskap. Følgelig tilsier den at religionen svekkes kraftig i møtet med moderniteten. Ikke nødvendigvis så kraftig at...

  6. Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements

    International Nuclear Information System (INIS)

    Lin, Kun-Ju; Lin, Wey-Yil; Hsieh, Chia-Ju; Weng, Yi-Hsin; Wey, Shiaw-Pyng; Lu, Chin-Song; Skovronsky, Daniel; Yen, Tzu-Chen; Chang, Chee-Jen; Kung, Mei-Ping

    2011-01-01

    18 F-9-fluoropropyl-(+)-dihydrotetrabenazine ( 18 F-AV-133) is a novel positron emission tomography tracer for imaging the vesicular monoamine transporter II in dopaminergic neuron degeneration, which might be indicative for Parkinson's disease (PD) and other parkinsonism. Studies were performed to optimize the imaging time window for calculating standardized uptake value ratio (SUVR) with correlation to distribution volume ratio (DVR) and in differentiating PD from normal controls (NCs). Methods: Thirteen 18 F-AV-133 positron emission tomography studies were conducted on four NCs (age, 62.3±4.9 years) and nine PD patients (age, 60.8±6.0 years) with Hoehn and Yahr stages 2 to 3. Dynamic images were acquired within 180 min (0–30, 50–140 and 160–180 min) and were rearranged into 14 of 10-min scans. The contralateral striatum was defined as the opposite striatum to the predominantly affected limbs. Volumes of interest (VOIs) of bilateral putamen, caudate nuclei and occipital cortex (OC; as the reference region) were delineated from individual magnetic resonance imaging. SUVRs of striatum to OC were computed from 14 dynamic image sets. The DVRs were computed from Logan graphic analysis by using OC as the input. The performance of SUVR was evaluated based on the correlation of SUVR at each time window to DVR, as well as the Cohen effect size (group mean SUVR difference between PD and NC/standard deviation). Results: 18 F-AV-133 uptake decreased in PD subjects at bilateral striatum especially at contralateral side with posterior putamen predominant as compared with NC. Consistent higher correlations of SUVRs to DVR for all VOIs were observed at later time window and reached to its maximal value of 0.9917 at 90–100 min. The group mean SUVR differences between NC and PD subjects increased and reached relatively stable values after 90 min. The effect sizes for all VOIs were stable across different time window and with the largest value around 90∼120 min

  7. Hybridapputveckling med Ionic Framework : Utveckling av en matbeställningsapplikation för Friends & Brgrs

    OpenAIRE

    West, Petter

    2016-01-01

    Det här arbetet beskriver planerandet, utvecklandet och testandet av en prototyp för en mobilapplikation (app) för hamburgerrestaurangen Friends & Brgrs. Olika teknologier för app-utveckling presenteras tillsammans med teorin för mobil appdesign. För utveckl-ingen användes ramverket Ionic Framework som genom hybridteknologin gör det möjligt att bygga en applikation med redan etablerade webstandarder. Som stöd under utveckl-ingen användes både det officiella hjälpmaterialet samt användargenera...

  8. Kjøttforbruk og klima : effektene av en klimaavgift på kjøtt

    OpenAIRE

    Hauge, Oda

    2017-01-01

    Denne oppgaven ser på hvilken effekt innføringen av klimaavgifter på kjøtt har på etterspørselen etter kjøtt og hvordan avgiftene vil påvirke klimagassutslippene fra kjøttproduksjon. For å utforske effektene konstrueres det en etterspørselsmodell med en særlig dekomponering på matvarer, som blir kalibrert mot et bestemt referanseår basert på ulike datakilder og estimater fra litteraturen. Det knyttes så utslipp til kjøttgodene i modellen, og godets utslippsintensitet blir regnet u...

  9. Novel measure of electrical dyssynchrony predicts response in cardiac resynchronization therapy: Results from the SMART-AV Trial.

    Science.gov (United States)

    Tereshchenko, Larisa G; Cheng, Alan; Park, Jason; Wold, Nicholas; Meyer, Timothy E; Gold, Michael R; Mittal, Suneet; Singh, Jagmeet; Stein, Kenneth M; Ellenbogen, Kenneth A

    2015-12-01

    Cardiac resynchronization therapy (CRT) reduces mortality and morbidity in selected heart failure patients. However, not all patients respond to CRT. We hypothesized that a novel measure of electrical dyssynchrony, sum absolute QRST integral (SAI QRST), predicts CRT response independent of QRS duration and morphology. We retrospectively analyzed baseline 12-lead electrocardiograms of SmartDelay Determined AV Optimization: A comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial study participants (N = 234; mean age 67 years; 163 (70%) men; 140 (60%) ischemic cardiomyopathy; mean left ventricular ejection fraction 25%; mean QRS duration 152 ms; 179 (77%) had left bundle branch block). Baseline pre-implant electrocardiograms were digitized, transformed into orthogonal XYZ, and analyzed automatically by customized MATLAB software. SAI QRST was measured as an averaged arithmetic sum of absolute areas under the QRST curve. Patients were followed prospectively 6 months after CRT-defibrillator implantation. Patients with a decrease in left ventricular end-systolic volume ≥15 mL after 6 months of CRT were considered responders. The logistic regression model was adjusted for age, sex, bundle branch block morphology, left ventricular ejection fraction, cardiomyopathy type, and QRS duration. Patients with the high mean SAI QRST (third tertile) had 2.5 times greater odds of response than those with the low mean SAI QRST (first tertile: odds ratio [OR] 2.5; 95% confidence interval [CI] 1.3-5.0; P = .010) and 1.9 times greater than the lower 2 tertiles combined (OR 1.9; 95% CI 1.1-3.5; P = .03). Adjustment for renal function (OR 2.33; 95% CI 1.32-4.11; P = .003) and left ventricular lead position in right anterior oblique and left anterior oblique views (OR 1.7; 95% CI 0.9-3.2; P = .087) did not attenuate association of SAI QRST with outcome. High SAI QRST independently predicts CRT response in the SMART-AV study. Copyright © 2015

  10. EKODESIGN I INDUSTRIN : En lägesanalys av producenters problem, drivkrafter och framtida utmaningar inom ekodesign

    OpenAIRE

    Bergsten, Karolina; Langborg, Ida

    2012-01-01

    SammanfattningProdukter produceras idag i stor utsträckning för att tillfredsställa konsumenters behov varpåmiljöbelastningen eskalerar i takt med efterfrågan och produktionen som sker därefter. Lösningenpå problemet kan sammanfattas i ekodesign där miljöoptimering av produktutvecklingen skerutifrån ett helhetsperspektiv; råvaruutvinning, produktion, användning, återvinning, slutligtomhändertagande samt transporter.Teknik-konsultföretaget ÅF uppmärksammade detta problem hos svenska producente...

  11. Friends on the other side. Fremstilling av religion og magi i Disney-filmen The Princess and the Frog

    OpenAIRE

    Sørbye, Vilde Marie Svanes

    2016-01-01

    Disney-konsernet er en stor distributør av barnefilmer og det er mulig at Disney-filmer kan påvirke hvordan barn oppfatter religion. Studier viser nemlig at film affekterer barn både kognitivt og følelsesmessig. Denne oppgaven tar for seg hvordan religion er fremstilt i Disney-filmen The Princess and the Frog. Metoden som er blitt brukt i denne oppgaven har vært å analysere religion og religiøse symboler i filmen. Religion og religiøse aspekter som ble funnet i filmen, ble kategorisert i føl...

  12. "Uten autisme, så er det ikke meg" : en kvalitativ tekstanalyse av internettfora som uttrykksmiddel for mennesker med autisme

    OpenAIRE

    Steensæth, Hege

    2009-01-01

    Bakgrunn, problemstilling og formål: Temaet i denne studien er hvordan internettfora kan være et uttrykksmiddel for mennesker med autisme og Aperger syndrom. Jeg vil fokusere på de to begrepene selvinnsikt og empati, og studere hvordan dette kommer til uttrykk blant denne gruppen mennesker på internett. Bakgrunnen for temavalget er interessen for diagnosen autisme. Internett er en viktig del av vår hverdag. Det er et nyttig redskap ikke minst i forhold til å holde kontakt med venner ...

  13. Efectos del tratado de libre comercio con Estados Unidos en el sub sector avícola colombiano

    OpenAIRE

    Cabrera Ortega, Andrea Carolina

    2015-01-01

    La industria avícola, es uno de los sub-sectores mas representativos en la economía, tanto de Estados Unidos como para Colombia en los últimos años. Esta industria en Colombia, ha logrado aumentar su producción, sin embargo el presente TLC firmado y puesto en marcha con Estados Unidos ha puesto en riesgo la Avicultura del Terrirtorio colombiano, debido a muchas diferencias, como el precio de venta, el cual el colombiano es mucho mayor al norteamerciano, diferencias en infraestructura, en ...

  14. Relationen mellan prokrastinering och upplevd stress : Effekter av cognitive behavioral stress management i stor grupp hos sjuksköterskestudenter

    OpenAIRE

    Vetso, Emelie

    2015-01-01

    Prokrastinering innebär att individen trots medvetenhet om negativa konsekvenser skjuter upp en handling. Den bidrar till stress, färre hälsofrämjade beteenden och sämre prestation. Demografiska faktorer och pågående utbildning påverkar sannolikheten för prokrastinering. Relationen mellan stress och prokrastinering behöver utforskas, speciellt hur interventioner riktade mot stress påverkar fenomenet. En longitudinell interventionsstudie med upprepad mätning undersökte effekten av ett KBT-base...

  15. Overvannsløsninger - status og utfordringer : en komparativ analyse av et utvalg land med tilsvarende klimatiske forhold som Norge

    OpenAIRE

    Skytterholm, Are

    2016-01-01

    Dette er en komparativ analyse av overvannssektoren i fem utvalgte land med tilsvarende klimatiske forhold som Norge. Hovedfokus er på finansieringsutfordringen bl.a. med vekt på om finansieringssystemet stimulerer til bærekraftighet . Siden finansieringsløsninger ofte i stor grad henger sammen med andre rammevilkår er også mål, strategier, ansvar og sentralt regelverk for overvannshåndteringen vurdert. Norge er det land som klart har kommet kortest når det gjelder avklaring ...

  16. Regeneración urbana, discurso patrimonial oficial y segregación social en la Av. 24 de Mayo

    OpenAIRE

    Ortega Lloré, Juan Fernando

    2014-01-01

    La ciudad de Quito, y en particular su Centro Histórico, atraviesan un nuevo ciclo de transformaciones. Esta investigación interroga por los impactos de las políticas de patrimonio y modernización en la vida social de la zona de la Av. 24 de Mayo (ubicada en el denominado casco antiguo de la capital ecuatoriana), y por el destino, en este contexto, de las dinámicas culturales y económicas de sectores populares como los que se asientan y transitan en esta franja de la urbe y en los barrios que...

  17. Emojis som ett universellt språk : En studie om Apple och Samsungs omvandling av universella koder

    OpenAIRE

    Tenggren, Maria

    2017-01-01

    Denna studie undersöker hur operativsystemen Apple och Samsung omvandlar universella koder till emojis och om de samspelar utseendemässigt. Med en semiotisk ansats fokuserar forskaren på att analysera emojis och dess visuella aspekter som skapar känslouttryck. Känslouttryck som i sin tur skapar tolkning och förståelse i människors digitala kommunikation. Studien baseras på tidigare forskning av Paul Ekman, Jaram Park, Young Min Baek, Meeyoung Cha och Rachel Scall. Genom en kvantitativ innehål...

  18. Descripción de la Estructura Organizacional del Area de Responsabilidad Social del Banco Av Villas

    OpenAIRE

    Malaver Ruiz, Juan Diego; Peña Ballen, Karen Tatiana

    2014-01-01

    Este proyecto describe el área de responsabilidad social, del Banco AV VILLAS. Para llevar a cabo esta descripción se estudiaran varios aspectos, como la importancia que la Responsabilidad Social tiene dentro de la organización, la estructura que la conforma, las acciones que se llevan a cabo bajo este concepto, las personas que se ven implicadas directa o indirectamente, entre otros. Se especifican los componentes de la estructura organizacional del área de responsabilidad social y...

  19. Employer branding i Statens vegvesen: en studie av hvordan employer branding kan vinkles for å forsterke organisasjonstilknytning

    OpenAIRE

    Sadovic, Una

    2017-01-01

    Masteroppgave - OLA 4090 Organisasjon, ledelse og arbeid. Universitetet i Oslo. Denne oppgaven vil berøre temaet employer branding. Et sterkt employer brand er med på å øke attraktiviteten til en arbeidsplass og medvirker på hvor lenge arbeidstakere blir værende hos en arbeidsgiver. Arbeid med employer branding kan ofte deles inn i to perspektiver, et internt og eksternt. Ifølge Maxwell og Knox (2009) er de fleste forskere opptatt av hva som gjør en organisasjon attraktiv for potensielle a...

  20. Plan de Prevención de Riesgos en Granja de Producción Avícola

    OpenAIRE

    Caraballo-Fernández, Esther

    2012-01-01

    La granja de producción avícola objeto de estudio no tiene actualmente un plan de prevención riguroso, aunque si se aplican algunas medidas básicas de seguridad como el uso de ciertos equipos de protección individual (por ejemplo botas de seguridad y guantes), al igual que se dispone de equipos de protección colectiva como extintores. Sin embargo, el responsable de la empresa, el técnico encargado de la granja, es consciente de que la instalación es deficiente en aspectos de segurida...

  1. Mezinárodní workshop k rizikům připravil Ústav geoniky AV ČR

    Czech Academy of Sciences Publication Activity Database

    Kolejka, Jaromír; Kirchner, Karel

    2017-01-01

    Roč. 36, č. 1 (2017), s. 51-53 ISSN 1213-1075 Institutional support: RVO:68145535 Keywords : international workshop * Strategy AV21 * Research Programme Natural hazards Subject RIV: DE - Earth Magnetism, Geodesy, Geography OBOR OECD: Physical geography

  2. K výsledkům činnosti knihoven AV ČR ve světle statistických údajů

    Czech Academy of Sciences Publication Activity Database

    Burgetová, Jarmila

    -, č. 3 (2012) E-ISSN 1805-2800 Keywords : Academic of Sciences Library * evaluation * statistical survey http://www.lib.cas.cz/casopis-informace/k-vysledkum-cinnosti-knihoven-av-cr-ve-svetle-statistickych-udaju/

  3. E-shop 'til you drop : En studie över e-handlares anpassning av den fysiska köpprocessen till ett virtuellt sammanhang

    OpenAIRE

    Alcazar, Alexander; Kastås, Sandra

    2011-01-01

    Denna magisteruppsats behandlar e-handlares anpassning av en fysisk köpprocess till en virtuell. Med detta syftar vi mer specifikt på e-handlare av modekläder som i högre grad är beroende av en fysisk köpprocess. Vår frågeställning var således: Hur gör e-handlare inom klädbranschen för att anpassa den fysiska köpprocessen till ett virtuellt sammanhang? För att undersöka detta använde vi oss av Overbys artikel "Process Virtualization Theory and the Impact of Information Technology" från 2008 d...

  4. GMP-compliant automated synthesis of [{sup 18}F]AV-45 (Florbetapir F 18) for imaging {beta}-amyloid plaques in human brain

    Energy Technology Data Exchange (ETDEWEB)

    Yao, C.-H. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Lin, K.-J. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Weng, C.-C. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Hsiao, I.-T. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Ting, Y.-S. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Yen, T.-C. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China); Jan, T.-R. [Department and Graduate Institute of Veterinary Medicine, National Taiwan University, Taipei, Taiwan (China); Skovronsky, Daniel [Avid Radiopharmaceuticals, Inc., Philadelphia, PA 19104 (United States); Kung, M.-P. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Wey, S.-P., E-mail: spwey@mail.cgu.edu.t [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 Wen-Hua 1st Road, Kweishan, Taoyuan 333, Taiwan (China)

    2010-12-15

    We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of {sup 18}F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of {beta}-amyloid (A{beta}) plaques in the brain of Alzheimer's disease patients. [{sup 18}F]AV-45 was prepared in 105 min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4{+-}7.7% with a final radiochemical purity of 95.3{+-}2.2% (n=19). The specific activity of [{sup 18}F]AV-45 reached as high as 470{+-}135 TBq/mmol (n=19). The present studies show that [{sup 18}F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

  5. Utvikling av læreres undervisningspraksis i matematikk som en utforskende og reflekterende virksomhet. En teoretisk og empirisk grunnet drøfting

    Directory of Open Access Journals (Sweden)

    Leif Kværnes

    2013-10-01

    Full Text Available I artikkelen retter jeg søkelyset mot læreres utvikling av egen undervisningspraksis og lærerkompetanse i matematikk. Mitt utgangspunkt er å se lærerkompetanse som noe profesjons- og handlingsrettet og å se læreres utvikling av kompetansen som en utforskende og reflekterende virksomhet. Først i artikkelen vil jeg drøfte og gjøre rede for disse utgangspunktene med bakgrunn i styringsdokumenter for læreutdanningen og ut fra utvalgte teoretiske utgangspunkt. Empiriske vil jeg belyse og drøfte læreres forsøk på utvikling av egen undervisningspraksis, og fokus er her på hvordan de gjennom refleksjon og ved bruk av teoretisk og forskningsbasert kunnskap kan skape grunnlag for en slik utvikling.

  6. Zajímavé výsledky skupiny kryogeniky a supravodivostí ÚPT AV ČR

    Czech Academy of Sciences Publication Activity Database

    Urban, Pavel; Hanzelka, Pavel; Jelínek, Josef; Králík, Tomáš; Musilová, Věra; Srnka, Aleš

    2008-01-01

    Roč. 53, č. 1 (2008), s. 20-23 ISSN 0447-6441 Institutional research plan: CEZ:AV0Z20650511 Keywords : cryogenics * superconductivity * radiative heat transfer * cryopump Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  7. GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging β-amyloid plaques in human brain

    International Nuclear Information System (INIS)

    Yao, C.-H.; Lin, K.-J.; Weng, C.-C.; Hsiao, I.-T.; Ting, Y.-S.; Yen, T.-C.; Jan, T.-R.; Skovronsky, Daniel; Kung, M.-P.; Wey, S.-P.

    2010-01-01

    We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18 F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of β-amyloid (Aβ) plaques in the brain of Alzheimer's disease patients. [ 18 F]AV-45 was prepared in 105 min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [ 18 F]AV-45 reached as high as 470±135 TBq/mmol (n=19). The present studies show that [ 18 F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

  8. [Minna Ahokas. Valistus suomalaisessa kirjakulttuurissa 1700-luvulla. Bidrag till kännedom av Finlands natur och folk 188] / Tuija Laine

    Index Scriptorium Estoniae

    Laine, Tuija, 1964-

    2012-01-01

    Arvustus: Minna Ahokas. Valistus suomalaisessa kirjakulttuurissa 1700-luvulla. Bidrag till kännedom av Finlands natur och folk 188. Diss. Sasatamala : Finska Vetenskaps-societeten. (Suomen Tiedeseura, 2011)

  9. Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models.

    Science.gov (United States)

    Meetze, Kristan; Vincent, Sylvie; Tyler, Steven; Mazsa, Elizabeth K; Delpero, Andrea R; Bottega, Steve; McIntosh, Donna; Nicoletti, Richard; Winston, William M; Weiler, Solly; Feng, Bin; Gyuris, Jeno; Weng, Zhigang

    2015-03-01

    ERBB3 is overexpressed in a broad spectrum of human cancers, and its aberrant activation is associated with tumor pathogenesis and therapeutic resistance to various anticancer agents. Neuregulin 1 (NRG1) is the predominant ligand for ERBB3 and can promote the heterodimerization of ERBB3 with other ERBB family members, resulting in activation of multiple intracellular signaling pathways. AV-203 is a humanized IgG1/κ ERBB3 inhibitory antibody that completed a first-in-human phase I clinical trial in patients with advanced solid tumors. The purpose of this preclinical study was to identify potential biomarker(s) that may predict response to AV-203 treatment in the clinic. We conducted in vivo efficacy studies using a broad panel of xenograft models representing a wide variety of human cancers. To identify biomarkers that can predict response to AV-203, the relationship between tumor growth inhibition (TGI) by AV-203 and the expression levels of ERBB3 and NRG1 were evaluated in these tumor models. A significant correlation was observed between the levels of NRG1 expression and TGI by AV-203. In contrast, TGI was not correlated with ERBB3 expression. The correlation between the levels of NRG1 expression in tumors and their response to ERBB3 inhibition by AV-203 was further validated using patient-derived tumor explant models. NRG1 is a promising biomarker that can predict response to ERBB3 inhibition by AV-203 in preclinical human cancer models. NRG1 warrants further clinical evaluation and validation as a potential predictive biomarker of response to AV-203. ©2014 American Association for Cancer Research.

  10. H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.

    Science.gov (United States)

    Li, Yeran; Wang, Chao; Cai, Weili; Sengupta, Saheli; Zavortink, Michael; Deng, Huai; Girton, Jack; Johansen, Jørgen; Johansen, Kristen M

    2017-09-15

    A model has been proposed in which JIL-1 kinase-mediated H3S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chromatin decondensation. However, here we show that although H3S10 phosphorylation is indeed compromised in the H2Av null mutant, chromatin decondensation at heat shock loci is unaffected in the absence of JIL-1 as well as of H2Av and that there is no discernable decrease in the elongating form of RNA polymerase II in either mutant. Furthermore, mRNA for the major heat shock protein Hsp70 is transcribed at robust levels in both H2Av and JIL-1 null mutants. Using a different chromatin remodeling paradigm that is JIL-1 dependent, we provide evidence that ectopic tethering of JIL-1 and subsequent H3S10 phosphorylation recruits PARP-1 to the remodeling site independently of H2Av phosphorylation. These data strongly suggest that H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila . © 2017. Published by The Company of Biologists Ltd.

  11. Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial.

    Science.gov (United States)

    Holmqvist, Fredrik; Hellkamp, Anne S; Lee, Kerry L; Lamas, Gervasio A; Daubert, James P

    2014-09-01

    Patients with a pacing indication and first-degree atrioventricular (AV)-block pose a clinical challenge. The prognostic impact of first-degree AV-block in patients with sinus node dysfunction and the impact of pacing in this setting are not known. In the Mode Selection Trial (MOST), 2,010 patients with sinus node dysfunction were randomized to either dual-chamber (DDD-R) or ventricular (VVI-R) pacing and followed for a median of 33 months. We report on clinical outcomes in patients with first-degree AV-block (PR interval > 200 ms) compared with patients who had a normal PR interval at baseline. Patients with first-degree AV-block (n = 378) were older (median [Q1, Q3]; 76 [70, 82] years vs 73 [66, 79] years, PAV-conduction (n = 1,159). In multivariable analyses, patients with first-degree AV-block were at greater risk of death, stroke, or heart failure hospitalization (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.06-1.61, P = 0.013). A trend towards a higher incidence of atrial fibrillation was seen (HR 1.24, 95% CI 0.98-1.55, P = 0.069). No significant interactions between pacing arm and prolonged versus normal PR were found for any endpoint, and hazard ratios were consistent across subgroups. First-degree AV-block is associated with more advanced disease but is still an independent predictor of poor clinical outcome. Neither DDD-R nor VVI-R pacing, as employed in MOST, eliminate the negative effects associated with first-degree AV-block. ©2014 Wiley Periodicals, Inc.

  12. [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    Science.gov (United States)

    Bevan-Jones, W R; Cope, Thomas E; Jones, P Simon; Passamonti, Luca; Hong, Young T; Fryer, Tim D; Arnold, Robert; Allinson, Kieren S J; Coles, Jonathan P; Aigbirhio, Franklin I; Patterson, Karalyn; O'Brien, John T; Rowe, James B

    2017-09-14

    Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test the specificity of in vivo binding of the putative tau ligand [ 18 F]AV-1451, which is elevated in frontotemporal lobar degeneration tauopathies. Seven patients (five with svPPA and two with 'right' semantic dementia) and 12 healthy controls underwent positron emission tomography brain imaging with [ 18 F]AV-1451. Two independent preprocessing methods were used. For both methods, all patients had clearly elevated binding potential (BP ND (non-displaceable binding potential)) in temporal lobes, lateralising according to their clinical syndrome and evident in raw images. Region of interest analyses confirmed that BP ND was significantly increased in temporal regions, insula and fusiform gyrus, consistent with those areas known to be most affected in semantic dementia. Hierarchical cluster analysis, based on the distribution of [ 18 F]AV-1451 binding potential, separated semantic dementia from controls with 86% sensitivity and 100% specificity. [ 18 F]AV-1451 binds in vivo regions that are likely to contain TDP-43 and not significant tau pathology. While this suggests a non-tau target for [ 18 F]AV-1451, the pathological regions in semantic dementia do not normally contain significant levels of recently proposed 'off target' binding sites for [ 18 F]AV-1451, such as neuronal monoamine oxidase or neuromelanin. Postmortem and longitudinal data will be useful to assess the utility of [ 18 F]AV-1451 to differentiate and track different types of frontotemporal lobar degeneration. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  13. Effects of AV delay and VV delay on left atrial pressure and waveform in ambulant heart failure patients: insights into CRT optimization.

    Science.gov (United States)

    Chan, W Y Wandy; Blomqvist, Andreas; Melton, Iain C; Norén, Kjell; Crozier, Ian G; Benser, Michael E; Eigler, Neal L; Gutfinger, Dan; Troughton, Richard W

    2014-07-01

    We hypothesized that left atrial pressure (LAP) obtained by a permanent implantable sensor is sensitive to changes in cardiac resynchronization therapy (CRT) settings and could guide CRT optimization to improve the response rate. We investigated the effect of CRT optimization on LAP and its waveform parameters in ambulant heart failure (HF) patients. CRT optimization was performed in eight ambulant HF patients, using echocardiography as reference. LAP waveform was acquired at each of eight atrioventricular (AV) intervals and five inter-ventricular (VV) intervals. Selected waveform parameters were also evaluated for their sensitivity to CRT changes and agreement with echocardiography-guided optimal settings. Optimal AV and VV intervals varied considerably between patients. All patients exhibited significant changes in waveform morphology with AV optimization. Optimal AV delay determined from echocardiography ranged between 140 ms and 225 ms. Mean LAP tended to be lower at optimal setting 14 ± 3 mmHg compared to shorter (160 ms) AV settings (P = 0.16). There were clear trends to smaller peak a-wave (P = 0.11) and gentler positive a-slope (P = 0.15) and positive v-slope (P = 0.09) with longer AV delays. Mean LAP and negative v-wave slope correlated well with echo-guided optimal setting, r = 0.91 (P = 0.001) and 0.79 (P = 0.03), respectively. No significant effects on LAP or waveform were seen during VV optimization. LAP and its waveform changes considerably with AV optimization. There is good agreement between echo-guided optimal setting and LAP. LAP could provide an objective guide to CRT optimization. (Clinical Trial Registry information: URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00632372). ©2014 Wiley Periodicals, Inc.

  14. Construcción de un índice de competitividad para el sector avícola colombiano

    Directory of Open Access Journals (Sweden)

    Camilo Alberto Calle Velásquez

    2015-07-01

    Full Text Available Este trabajo plantea la construcción de un índice de competitividad para el sector avícola colombiano. Para construir el índice compuesto de competitividad se propusieron, mediante análisis de componentes principales (ACP, cuatro dimensiones que explican la competitividad. Estas dimensiones son: conocimiento (IC: 33,62%, dimensión productiva (IP: 26,94%, dimensión económica (IE: 26,84% y dimensión tecnológica (IT: 12,57%. Se encontró que las regiones más competitivas en 2002 fueron, en orden descendente: Santander, Boyacá, Cundinamarca y Antioquia. Se puede concluir que la competitividad es un fenómeno multidimensional y que las variables asociadas con el origen de los recursos económicos estuvieron estrechamente relacionadas con las otras variables consideradas.

  15. Forro ecológico de resíduos agroindustriais para galpões avícolas

    Directory of Open Access Journals (Sweden)

    Julio Cesar Machado Cravo

    2014-01-01

    Full Text Available A avicultura brasileira é uma atividade econômica com expressiva participação no agronegócio brasileiro, porém o setor se depara com desafios, entre esses, destaca-se o estresse térmico dos animais provocado pelas variações climáticas. Dentro desse contexto, este trabalho teve como objetivo estudar as propriedades térmicas de um forro ecológico de baixa densidade a base de partículas de resíduos agroindustriais (casca de amendoim e fibra de coco verde aglutinadas com resina poliuretana bi-componente à base de óleo de mamona e avaliar seu desempenho quando aplicado como forro em galpões avícolas. Os resultados obtidos demonstram a eficiência do material quando aplicado como forro em aviários.

  16. Objektorienterad programmering på teknikprogrammet. : Vad lär sig gymnasieelever av programmering vidC-sharplektioner?

    OpenAIRE

    Barsk, Ulla-Maija

    2013-01-01

    Studien problematiserade gymnasieelevers lärande i perspektivet: Lär sig elever förmågan att programmera eller lär de sig enbart programmeringsspråket? Syftet var att undersöka och analysera hur elever lär sig att programmera och om de lär sig tankesättet för att praktiskt tillämpa sina kunskaper av ett objektorienterat språk. Frågeställningar var: Hur uppfattar elever programmeringen och på vilket sätt lär de sig att programmera,dvs. kan de ta till sig programmeringsspråket för att lösa prob...

  17. A Study of Mild Steel Corrosion Using Adhatoda Vasica (AV Extract as Inhibitor in Different Acid Medium

    Directory of Open Access Journals (Sweden)

    P. Matheswaran

    2010-01-01

    Full Text Available Corrosion behavior of mild steel in acidic medium using Adhatoda Vasica (AV extract was investigated. The inhibitive effective of Adhatoda Vasica on the corrosion of mild steel in different acidic medium has been studied by weight loss and polarization methods. The Ecorr values are shifted slightly towards negative side in presence of inhibitors which indicate the inhibitors inhibit the corrosion of mild steel in acids solution by controlling both anodic and cathodic reactions due to the blocking of active sites on the metal surface. It is evident that inhibitors bring about considerable polarization of the cathode as well as anode. It was, therefore, inferred that the inhibitive action is of mixed type.

  18. ANÁLISE COMPARATIVA DE DESEMPENHO DE REDES RESIDENCIAIS IEEE 802.11N E HOMEPLUG AV

    Directory of Open Access Journals (Sweden)

    Antonio Luiz P. S. Campos

    2014-01-01

    Full Text Available Este artigo apresenta uma análise comparativa dos padrões 802.11n e Homeplug AV, abordando melhorias desses padrões com relação aos seus anteriores. São realizados testes do desempenho de cada padrão em ambiente residencial, considerando como parâmetro analisado a taxa de transmissão. O interesse foi determinar o desempenho relativo destas tecnologias, considerando a taxa de transmissão em função da distância de transmissão, do tamanho dos pacotes e do número de nós ativos na rede.

  19. A Study of Subseasonal Predictability of the Atmospheric Circulation Low-frequency Modes based on SL-AV forecasts

    Science.gov (United States)

    Kruglova, Ekaterina; Kulikova, Irina; Khan, Valentina; Tischenko, Vladimir

    2017-04-01

    The subseasonal predictability of low-frequency modes and the atmospheric circulation regimes is investigated based on the using of outputs from global Semi-Lagrangian (SL-AV) model of the Hydrometcentre of Russia and Institute of Numerical Mathematics of Russian Academy of Science. Teleconnection indices (AO, WA, EA, NAO, EU, WP, PNA) are used as the quantitative characteristics of low-frequency variability to identify zonal and meridional flow regimes with focus on control distribution of high impact weather patterns in the Northern Eurasia. The predictability of weekly and monthly averaged indices is estimated by the methods of diagnostic verification of forecast and reanalysis data covering the hindcast period, and also with the use of the recommended WMO quantitative criteria. Characteristics of the low frequency variability have been discussed. Particularly, it is revealed that the meridional flow regimes are reproduced by SL-AV for summer season better comparing to winter period. It is shown that the model's deterministic forecast (ensemble mean) skill at week 1 (days 1-7) is noticeably better than that of climatic forecasts. The decrease of skill scores at week 2 (days 8-14) and week 3( days 15-21) is explained by deficiencies in the modeling system and inaccurate initial conditions. It was noticed the slightly improvement of the skill of model at week 4 (days 22-28), when the condition of atmosphere is more determined by the flow of energy from the outside. The reliability of forecasts of monthly (days 1-30) averaged indices is comparable to that at week 1 (days 1-7). Numerical experiments demonstrated that the forecast accuracy can be improved (thus the limit of practical predictability can be extended) through the using of probabilistic approach based on ensemble forecasts. It is shown that the quality of forecasts of the regimes of circulation like blocking is higher, than that of zonal flow.

  20. Third-degree AV block from extended-release diltiazem ingestion in a nine-month-old.

    Science.gov (United States)

    Wills, Brandon K; Liu, J Marc; Wahl, Michael

    2010-04-01

    Calcium channel blocker (CCB) overdose is associated with dysrhythmias and atrioventricular (AV) block, however, experience with infant CCB overdose is limited. A 9-month-old girl was found playing with tablets of extended-release diltiazem 120 mg. The patient had two episodes of emesis, which contained pill fragments, and was brought to the Emergency Department (ED) 4.5 h after being found. Vital signs were: rectal temperature 37.1 degrees C, pulse 87 beats/min, respiratory rate 30-40 breaths/min, blood pressure 72/48 mm Hg, and oxygen saturation (SpO(2)) 99% on room air. Otherwise, the patient was well-appearing, with normal skin color and examination. The electrocardiogram revealed third-degree atrioventricular block with a ventricular rate of 90 beats/min, QRS 68 ms, and QTc 411 ms. Atropine 0.1 mg i.v. was given, which increased the heart rate to 100-110 beats/min. Calcium gluconate 500 mg was also given intravenously. Laboratory evaluation revealed bicarbonate 17 mEq/L, anion gap 16, and glucose 129 mg/dL. On hospital day 1, the patient was noted to have a junctional rhythm with a rate of 90-100, and systolic blood pressure of 80-90 mm Hg. No additional medications were given. Early on day 2, the patient converted spontaneously to a normal sinus rhythm and was discharged approximately 42 h after presentation to the ED. In addition to bradycardia and hypotension, this 9-month-old patient manifested third-degree AV block after ingesting extended-release diltiazem. Copyright 2010 Elsevier Inc. All rights reserved.

  1. Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations.

    Science.gov (United States)

    Dardiotis, Efthimios; Siokas, Vasileios; Zafeiridis, Tilemachos; Paterakis, Konstantinos; Tsivgoulis, Georgios; Dardioti, Maria; Grigoriadis, Savas; Simeonidou, Constantina; Deretzi, Georgia; Zintzaras, Elias; Jagiella, Jeremiasz; Hadjigeorgiou, Georgios M

    2017-03-01

    Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was designed to investigate possible influence of integrin AV (ITGAV) and integrin B8 (ITGB8) gene region polymorphisms on the risk of ICH. 1015 participants (250 Greek and 193 Polish patients with primary ICH and 250 Greek and 322 Polish controls) were included in the study. Using logistic regression analyses, 11 tag single nucleotide polymorphisms (SNPs) for ITGAV and 11 for ITGB8 gene were tested for associations with ICH risk, lobar ICH risk and non-lobar ICH after adjustment for age, gender, history of hypertension and country of origin. Linear regression models were used to test the effect of tag SNPs on the ICH age of onset. Correction for multiple comparisons was carried out. The rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in the codominant model of inheritance [odds ratio (95 % confidence interval (CI)) 0.56 (0.36-0.86), p = 0.0013]. Furthermore, heterozygous individuals of the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes [regression coefficient (b) -3.884 (95 % CI -6.519, -1.249), p = 0.0039 and b = -4.502 (95 % CI -7.159, -1.845), p = 0.0009, respectively]. The present study provides preliminary indication for an influence of ITGAV gene tag SNP in the development of lobar ICH and of ITGB8 gene variants in the age of ICH onset.

  2. Effect of the electropositive elements A = Sc, La, and Ce on the microscopic dynamics of AV2Al20.

    Science.gov (United States)

    Koza, Michael Marek; Leithe-Jasper, Andreas; Sischka, Erik; Schnelle, Walter; Borrmann, Horst; Mutka, Hannu; Grin, Yuri

    2014-12-28

    We report on the inelastic response of AV2Al20 (with A = Sc, La and Ce) probed by high-resolution inelastic neutron scattering experiments. Intense signals associated with the dynamics of Sc, La and Ce are identified in the low-energy range at 6-14 meV in ScV2Al20 and at 8-16 meV in LaV2Al20 and CeV2Al20. Their response to temperature changes between 2 and 300 K reveals a very weak softening of the modes upon heating in LaV2Al20 and CeV2Al20 and a distinguished blue shift by about 2 meV in ScV2Al20. By means of density functional theory (DFT) and lattice dynamics calculations (LDC) we show that the unusual anharmonicity of the Sc-dominated modes is due to the local potential of Sc featured by a strong quartic term. The vibrational dynamics of ScV2Al20 as well as of LaV2Al20 and CeV2Al20 is reproduced by a set of eigenmodes. To screen the validity of the DFT and LDC results they are confronted with data from X-ray diffraction measurements. The effect of the strong phonon renormalization in ScV2Al20 on thermodynamic observables is computed on grounds of the LDC derived inelastic response. To set the data in a general context of AV2Al20 compounds and their physical properties we report in addition computer and experimental results of the binary V2Al20 compound.

  3. I betraktarens ögon – Betydelsen av kön och ålder för studenters läraromdömen

    Directory of Open Access Journals (Sweden)

    Martin Karlsson

    2011-12-01

    Full Text Available Under senare år har studenters läraromdömen allt mer hamnat i fokus inom skola såväl som högre utbildning. Parallellt med dessa utvecklingar har olika typer av internettjänster genom vilka studenter kan betygsätta sina lärare dykt upp i flera länder. I Sverige lanserades 2008 tjänsten ”Studenter tycker till” (STT där studenter kan registrera sig och fylla i bedömningar av lärare enligt kriterierna utlärningsförmåga, kunskap, engagemang och lärandestöd. I denna studie undersöks betydelsen av lärarens kön och ålder för studenters läraromdömen genom en kvantitativ analys av omdömen av 98 högskole- och universitetslärare som givits på hemsidan STT. Syftet är att synliggöra hur sociala markörer, i detta fall om läraren är man eller kvinna, ung eller gammal, spelar en stor roll för hur en lärare utvärderas. Resultaten visar att kvinnor och unga lärare systematiskt ges lägre betyg av studenter, än män och äldre lärare. Studenter är således inte könsblinda eller oberoende av föreställningar om förhållandet mellan ålder och kompetens i sina bedömningar. Studien aktualiserar betydelsen av sociala markörer så som kön och ålder måste synliggöras och tas i beaktning när studenters utvärderingar av lärare och kurser behandlas inom högre utbildning.

  4. A new method of building permanent A-V block model: ablating his-bundle potential through femoral artery with pre-implanted biventricular pacemaker.

    Science.gov (United States)

    Cheng, Zheng; Hai-ge, Ye; Jin, Li; Wan-chun, Ye; Lu-ping, Wang; Yue-chun, Li; Jia-Feng, Lin

    2014-11-20

    To explore the feasibility of a new method of achieving a permanent A-V block animal model. 16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the aortic sinus, through femoral artery. (2) In the second group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the triangle of Koch, through femoral vein. A complete A-V block model was achieved as a standard in this study. The success rates, intraoperative arrhythmias, operative and X-ray exposure time, intraoperative bleeding amount were assessed in this two groups, both animal models were followed up for four weeks and then fasted to monitor myocardial pathological changes. The success rate of the first group, which with fewer intraoperative arrhythmias, and less operative and X-ray exposure time, was significantly higher than the second group. Compared with traditional animal method, our new method of ablating his-bundle potential at the left ventricle from the femoral artery has a higher success rate, fewer occurrence of malignant arrhythmias, and less operation and X-ray time. Thus, our new method should be preferred in the building of Permanent A-V Block Model.

  5. Assessment of Multiple Risk Outcomes, Strengths, and Change with the START:AV: A Short-Term Prospective Study with Adolescent Offenders

    Science.gov (United States)

    Viljoen, Jodi L.; Beneteau, Jennifer L.; Gulbransen, Erik; Brodersen, Etta; Desmarais, Sarah L.; Nicholls, Tonia L.; Cruise, Keith R.

    2012-01-01

    The Short-Term Assessment of Risk and Treatability: Adolescent Version (START:AV; Nicholls, Viljoen, Cruise, Desmarais, & Webster, 2010; Viljoen, Cruise, Nicholls, Desmarais, & Webster, in preparation) is a clinical guide designed to assist in the assessment and management of adolescents’ risk for adverse events (e.g., violence, general offending, suicide, victimization). In this initial validation study, START:AV assessments were conducted on 90 adolescent offenders (62 male, 28 female), who were prospectively followed for a 3-month period. START:AV assessments had good to excellent inter-rater reliability and strong concurrent validity with Structured Assessment of Violence Risk in Youth assessments (SAVRY; Borum, Bartel, & Forth, 2006). START:AV risk estimates and Vulnerability total scores predicted multiple adverse outcomes, including violence towards others, offending, victimization, suicidal ideation, and substance abuse. In addition, Strength total scores inversely predicted violence, offending, and street drug use. During the 3-month follow-up, risk estimates changed in at least one domain for 92% of youth, and 27% of youth showed reliable changes in Strength and/or Vulnerability total scores (reliable change index, 90% confidence interval; Jacobsen & Truax, 1991). While these findings are promising, a strong need exists for further research on the START:AV, the measurement of change, and on the role of strengths in risk assessment and treatment-planning. PMID:23436983

  6. IFRS 3 och IAS 38 : Redovisning av immateriella tillgångar vid företagsförvärv

    OpenAIRE

    Palmér, Viktor; Olsson, Mattias

    2007-01-01

    Från och med 2005 ska svenska börsnoterade bolag använda sig av IFRS/IAS-regelverken, detta är ett steg i den konvergering av redovisningsregler som sker inom EU. Den här uppsatsen behandlar IFRS 3 som rör företagsförvärv och IAS 38 som innehåller regler om immateriella tillgångar. Efter en genomgång av teori och regelverk ser vi närmare på några stora svenska företag som gjort förvärv efter att de nya reglerna införts, och se hur förändringarna påverkat företagens redovisning. Detta har vi g...

  7. Köpbeteende i integrerade handelskanaler : En kvantitativ studie om integrerade handelskanaler & dess påverkan på kundens köp av elektronikprodukter

    OpenAIRE

    Hedenström, Lisa; Jakobsen, Nina

    2016-01-01

    Uppkomsten av internet och smarta teknologier har lett till en strukturomvandling kring kom-munikationen mellan kunder och företag. Internet har inneburit nya handelskanaler så som on-line butik, mobila applikationer med mera. Företag erbjuder således allt fler olika handels-kanaler för att nå ut till kunder. Detta har i sin tur lett till att kunder använder olika handels-kanaler i processen av att genomföra ett köp, kundens köpbeteende har således förändrats.  I och med uppkomsten av fler ha...

  8. Regional Amyloid Deposition in Amnestic Mild Cognitive Impairment and Alzheimer's Disease Evaluated by [18F]AV-45 Positron Emission Tomography in Chinese Population

    Science.gov (United States)

    Hsiao, Ing-Tsung; Kuo, Hung-Chou; Hsu, Wen-Chuin; Chuang, Wen-Li; Kung, Mei-Ping; Wey, Shiaw-Pyng; Hsieh, Chia-Ju; Wai, Yau-Yau; Yen, Tzu-Chen; Huang, Chin-Chang

    2013-01-01

    Background To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [18F]AV-45 positron emission tomography (PET). Materials and Methods [18F]AV-45 PET was performed in 11 CN, 13 aMCI, and 12 AD subjects to compare the cerebral cortex-to-whole cerebellum standard uptake value ratios (SUVRs) of global and individual volumes of interest (VOIs) cerebral cortex. The correlation between global cortical [18F]AV-45 SUVRs and Mini-Mental State Examination (MMSE) scores was analyzed. Results The global cortical [18F]AV-45 SUVRs were significantly different among the CN (1.08±0.08), aMCI (1.27±0.06), and AD groups (1.34±0.13) (p = 0.0003) with amyloidosis positivity rates of 9%, 62%, and 92% in the three groups respectively. Compared to CN subjects, AD subjects had higher SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, and posterior cingulate areas; while aMCI subjects had higher values in the global cortical, precuneus, frontal, occipital and posterior cingulate areas. There were negative correlations of MMSE scores with SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, posterior cingulate and anterior cingulate areas on a combined subject pool of the three groups after age and education attainment adjustment. Conclusions Amyloid deposition occurs relatively early in precuneus, frontal and posterior cingulate in aMCI subjects. Higher [18F]AV-45 accumulation is present in parietal, occipital and temporal gyri in AD subjects compared to the aMCI group. Significant correlation between MMSE scores and [18F]AV-45 SUVRs can be observed among CN, aMCI and AD subjects. PMID:23516589

  9. Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

    Science.gov (United States)

    Dickstein, D L; Pullman, M Y; Fernandez, C; Short, J A; Kostakoglu, L; Knesaurek, K; Soleimani, L; Jordan, B D; Gordon, W A; Dams-O'Connor, K; Delman, B N; Wong, E; Tang, C Y; DeKosky, S T; Stone, J R; Cantu, R C; Sano, M; Hof, P R; Gandy, S

    2016-09-27

    Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as a tauopathy. Currently, the diagnosis of CTE can only be definitively established postmortem. However, a new positron emission tomography (PET) ligand, [ 18 F]T807/AV1451, may provide the antemortem detection of tau aggregates, and thus various tauopathies, including CTE. Our goal was to examine [ 18 F]T807/AV1451 retention in athletes with neuropsychiatric symptoms associated with a history of multiple concussions. Here we report a 39-year-old retired National Football League player who suffered 22 concussions and manifested progressive neuropsychiatric symptoms. Emotional lability and irritability were the chief complaints. Serial neuropsychological exams revealed a decline in executive functioning, processing speed and fine motor skills. Naming was below average but other cognitive functions were preserved. Structural analysis of longitudinally acquired magenetic resonance imaging scans revealed cortical thinning in the left frontal and lateral temporal areas, as well as volume loss in the basal ganglia. PET with [ 18 F]florbetapir was negative for amyloidosis. The [ 18 F]T807/AV1451 PET showed multifocal areas of retention at the cortical gray matter-white matter junction, a distribution considered pathognomonic for CTE. [ 18 F]T807/AV1451 standard uptake value (SUV) analysis showed increased uptake (SUVr⩾1.1) in bilateral cingulate, occipital, and orbitofrontal cortices, and several temporal areas. Although definitive identification of the neuropathological underpinnings basis for [ 18 F]T807/AV1451 retention requires postmortem correlation, our data suggest that [ 18 F]T807/AV1451 tauopathy imaging may be a promising tool to detect and diagnose CTE-related tauopathy in living subjects.

  10. Effektiva team : Hur skiljer sig industrigrupper från andra typer av arbetsgrupper från en större population?

    OpenAIRE

    Kokora, Marijana

    2011-01-01

    Studiens syfte var att undersöka hur grupper inom en industri skiljer sig från andra typer av arbetsgrupper från en större population. I den här studien användes Team Diagnostic Survey (TDS). TDS instrumentet används för att mäta faktorer som anses vara avgörande för gruppens effektivitet enligt en modell av Hackman (2002). Den statistiska bearbetningen visade på 12 signifikanta skillnader. Skillnader visade sig inom följande områden: compelling direction, enabling direction, supportive organ...

  11. Mitigation of methane emissions in a pilot-scale biocover system at the AV Miljø Landfill, Denmark: 1. System design and gas distribution

    DEFF Research Database (Denmark)

    Cassini, Filippo; Scheutz, Charlotte; Skov, Bent Henning

    2017-01-01

    -passive biocover system was constructed at the AV Miljø Landfill, Denmark. The biocover system was fed by landfill gas pumped out of three leachate collection wells. An innovative gas distribution system was used to overcome the commonly observed surface emission hot spot areas resulting from an uGreenhouse gas...... was constructed at the AV Miljø Landfill, Denmark. The biocover system was fed by landfill gas pumped out of three leachate collection wells. An innovative gas distribution system was used to overcome the commonly observed surface emission hot spot areas resulting from an uneven gas distribution to the active...

  12. Är prostitution en kränkning av mänskliga rättigheter? : Eller finns "den lyckliga horan"?

    OpenAIRE

    Nilsson, Ulrika

    2014-01-01

    Att människohandel för sexuell exploatering utgör ett brott mot mänskliga rättigheter står klart. Människohandel kränker flertalet av individens rättigheter och staters skyldigheter gentemot dessa individer finns således stadgade i flertalet internationella konventioner. Palermoprotokollet stadgar den första internationellt gemensamma definitionen av människohandel och stadgar vidare ett krav på att definitionen utgör ett brott i konventionsstaternas nationella lagstiftning. Om prostitution a...

  13. En sammenligning av muskelaktivering i gluteus maximus i hip-thrust, vektløfterbøy og styrkeløfterbøy

    OpenAIRE

    Liljegren, Anja Margrethe; Sørlie, Eileen

    2016-01-01

    Objektivt. Hensikten med denne oppgaven er å finne ut om hip-thrust er en bedre øvelse for å trene gluteus maximus enn knebøy. Oppgaven tar utgangspunkt i å måle muskelaktiviteten i gluteus maximus i øvelsene, hip-thrust, vektløfterbøy og styrkeløfterbøy. Problemstillingen vi har jobbet ut fra er: Hvilken øvelse aktiverer gluteus maximus i større grad av hip-thrust, vektløfterbøy og styrkeløfterbøy? Metode. I denne oppgaven benytter vi oss av kvantitativ metode. Vi har gjennom ...

  14. Strategi - fra teori til praksis. Utøvelse av strategisk ledelse på Re-ledernivå i Ringsaker kommune

    OpenAIRE

    Græsby, Linda; Nilssen, Roger; Vik, Svein Kåre

    2016-01-01

    Erfaringsbasert master 90 poeng Tema for denne studien er strategisk ledelse i kommunesektoren. Formålet er å undersøke om utøvelsen av ledelse blant resultatenhetsledere i Ringsaker kommune er strategisk. Relatert til dette, har vi også undersøkt hvilken betydning kommunens overordnede strategi for å realisere «vekst og utvikling» har for den enkelte leders utøvelse av ledelse i egen enhet. Strategifaget er utviklet i «grenselandet» mellom ledelsesteori og ledelsespraksis (Witti...

  15. Employer branding. : - En fallstudie vid Sandvik AB om uppfattningar av begreppet employer branding och hur detta tillämpas idag och i framtiden.

    OpenAIRE

    Eriksson, Johan

    2012-01-01

    Employer branding är ett begrepp som är aktuellt bland företagen just nu och allt fler väljer att satsa på employer branding som marknadsföringsstrategi. Den här studien handlar om employer branding på Sandvik och begreppet employer branding.Syftet med denna fallstudie av en global koncern är att förklara och beskriva begreppet employerbranding, samt hur man arbetar med detta och vilka framtidsvisioner man har på Sandvik.Studien genomfördes med hjälp av kvalitativa intervjuer med ett antal ny...

  16. En modell for jordmorstudenters praktiske studier sett i lys av ulike læringsteorier – et vitenskapelig essay

    Directory of Open Access Journals (Sweden)

    Ingvild Aune

    2014-05-01

    Full Text Available I prosjektet «Kontinuitet i omsorgen gjennom svangerskap, fødsel og barseltid» var målet å få kunnskap om hvorvidt en slik modell i de praktiske studiene ville gi jordmorstudentene en økt forståelse for jordmorfaget, med vekt på å fremme et normalt svangerskap, fødsel og barseltid. Målsettingen med dette vitenskapelige essayet er å sette prosjektet inn i en pedagogisk referanseramme, der jordmorstudentenes læreprosess og den grunnleggende forståelsen for jordmorfaget ses i lys av ulike læringsteorier. Jordmorstudentenes læring kan settes i et overordnet konstruktivistisk og sosiokulturelt perspektiv. Carl Rogers teori om relasjonens betydning som en forutsetning for å utvikle personlig vekst og modenhet er sentral. Helhetlig læring er en prosess som berører hele mennesket i interaksjon med sine omgivelser, og i denne betydningen inkluderer læring utvikling av relasjoner. Det var nyttig å benytte Carr og Kemmis modell som et verktøy for å analysere aksjonslæringsprosessen, siden denne modellen tar hensyn til den sosiale dimensjonen med samhandling mellom aktørene. Summary In the project «Continuity of care during pregnancy, childbirth and the postnatal period», the objective was to gain insight into whether the outlined model of care in practical studies would increase student midwives’ understanding of midwifery when the emphasis was on the promotion of normal pregnancy, childbirth and the postnatal period. The aim of this scientific essay is to put the project into a pedagogic framework in which the student midwives’ learning process and fundamental understanding of midwifery are viewed in the light of different learning theories. The learning of student midwives can be studied through constructivist and socio-cultural perspectives. Carl Roger's theory of the significance of relationships for achieving personal growth and maturity is essential. Holistic learning is a process that emphasizes the human wholeness in

  17. Uten lovlig opphold = uten rettigheter? Tilværelsen til migranter uten oppholdstillatelse i lys av normativ teori om rettferdighet

    Directory of Open Access Journals (Sweden)

    Katrine Fangen

    2012-11-01

    Full Text Available Migranter som fortsetter å oppholde seg i et land etter avslag på søknad om opphold, eller som unnlater å søke om oppholdstillatelse, utfordrer det juridiske rammeverket for nasjonalstater og statsborgerskap. I denne artikkelen diskuteres livssituasjonen til migranter uten lovlig opphold opp mot normativ kosmopolitisk teori om universelle rettigheter. Dette er belyst i internasjonal litteratur, men i mindre grad innenfor en norsk kontekst. Vi tar i denne artikkelen for oss tre empiriske eksempler: tilværelsen i såkalte ventemottak, tilværelsen utenfor ventemottakene og tilværelsen for barn uten lovlig opphold. Gjennom eksemplene diskuterer vi rettighetsspørsmål i migrantenes liv. Vi viser hvordan menneskerettighetene ikke er tilstrekkelige for å ivareta migrantenes velvære, og hvordan rettigheter migrantene faktisk har, ikke fremstår som reelle fordi det oppleves som risikabelt å benytte seg av dem. Artikkelen setter normativ kosmopolitisk teori i perspektiv ved å diskutere den konkrete situasjonen til migrantene, og spør til slutt hva som kan være konsekvensene av at rettigheter blir ulikt fordelt?Nøkkelord: rettferdighet, rettigheter, migrasjon, ulovlig opphold, kosmopolitismeEnglish summary: Without legal residency = no rights? A discussion of the situation of migrants who have settled without official authorisation, in light of the normative theory of justiceMigrants who continue to reside in a country after having received a negative answer to their residence application, or who stay without registering themselves in the first place, challenge the legal framework of national states and citizenship. In this article, we illustrate the situation of migrants without legal residence in light of normative cosmopolitan theory focusing on the universality of rights. We discuss three empirical contexts: life in the so-called waiting reception centers, life outside the waiting reception centers, and the situation of children

  18. Utveckling av internt Administrationssystem

    OpenAIRE

    Lind, Jonas

    2014-01-01

    This thesis work is executed at Business Unit Ericsson Test Environment (BETE), in Linköping. BETE is the department at Ericsson, which is responsible for the operation and maintenance of the company's Operations Support System (OSS). Their management system was outdated and they wanted it to be updated and it also required new features. The database needed to be replaced and the data migrated to a new database without licensing costs. The system also needed a part where employees could manag...

  19. Fri flyt av forskning

    CERN Document Server

    Vigen, Jens

    2007-01-01

    The author advocates free access to scientific results. Libraries have been faced with the so-called serial crisis for more than 20 years and cannot any longer cope with the financial burden it implies. The 350 years old publishing model for scientific journals is being challenged by new technology. The particle physics community is currently developing a new business model for Open Access publishing; referred to as SCOAP3.

  20. Processdesign av emulsionsberedningssystem

    OpenAIRE

    Calmanovici Pacoste, Laura; Boman, Daniel; Ardakani, Rebecka; Degerman, Martina; Kammarbo, Emil; Näslund, Emil

    2016-01-01

    At the request of Fresenius Kabi an emulsion preparation system was designed with a maximum production capacity of  15 L and minimum of 3 L emulsion. The system was required to consist of one oil-tank, one pre-emulsion tank, two storage tanks and one homogenizer. The storage tanks were positioned on a movable carriage on the left side of the homogenizer and the pre-emulsion tank and oil tank was placed on a separate frame on the right side of the homogenizer. All tanks were equipped with indi...

  1. Ivaretakelse av pasientsikkerhet

    OpenAIRE

    Berland, Astrid; Natvig, Gerd Karin

    2005-01-01

    The main purpose of this article is to study what nurses consider most important when focusing on patient safety. The study uses a qualitative design based on focus group interviews with nurses who work with acute, critically ill patients in hospitals. Two hospitals were chosen. The data collection was conducted in October and November 2002. The research comprised 23 nurses with specialist degrees, including one man, divided into four groups. The criterion for inclusion i...

  2. Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]AV-133) in a MPTP-lesioned PD mouse model.

    Science.gov (United States)

    Chao, Ko-Ting; Tsao, Hsin-Hsin; Weng, Yi-Hsin; Hsiao, Ing-Tsung; Hsieh, Chia-Ju; Wey, Shiaw-Pyng; Yen, Tzu-Chen; Kung, Mei-Ping; Lin, Kun-Ju

    2012-09-01

    [¹⁸F]AV-133 is a novel PET tracer for targeting the vesicular monoamine transporter 2 (VMAT2). The aim of this study is to characterize and quantify the loss of monoamine neurons with [¹⁸F]AV-133 in the MPTP-lesioned PD mouse model using animal PET imaging and ex vivo quantitative autoradiography (QARG). Optimal imaging time window of [¹⁸F]AV-133 was first determined in normal C57BL/6 mice (n = 3) with a 90-min dynamic scan. The reproducibility of [¹⁸F]AV-133 PET imaging was evaluated by performing a test-retest study within 1 week for the normal group (n = 6). For MPTP-lesioned studies, normal, and MPTP-treated [25 mg mg/kg once (Group A) and twice (Group B), respectively, daily for 5 days, i.p., groups of four normal and MPTP-treated] mice were used. PET imaging studies at baseline and at Day 4 post-MPTP injections were performed at the optimal time window after injection of 11.1 MBq [¹⁸F]AV-133. Specific uptake ratio (SUr) of [¹⁸F]AV-133 was calculated by [(target uptake-cerebellar uptake)/cerebellar uptake] with cerebellum as the reference region. Ex vitro QARG and immunohistochemistry (IHC) studies with tyrosine hydroxylase antibody were carried out to confirm the abundance of dopaminergic neurons. The variability between [¹⁸F]AV-133 test-retest striatal SUr was 6.60 ± 3.61% with less than 5% standard deviation between animals (intervariability). The percentages of MPTP lesions were Group A 0.94 ± 0.29, -42.1% and Group B 0.65 ± 0.09, -60.4%. By QARG, specific binding of [¹⁸F]AV-133 was reduced relative to the control groups by 50.6% and 60.7% in striatum and by 30.6% and 46.4% in substantia nigra (Groups A and B, respectively). Relatively small [¹⁸F]AV-133 SUr decline was noted in the serotonin and norepinephrine-enriched regions (7.9% and 9.4% in mid-brain). Results obtained from IHC consistently confirmed the sensitivity and selectivity of dopaminergic neuron loss after MPTP treatment. [¹⁸F]AV-133 PET SUr displayed a high

  3. Kan kostholdsdata fra hjerte- karundersøkelsene i Finnmark, Sogn og Fjordane og Oppland brukes i analyser av andre sykdommer enn hjerte-karsykdom?

    Directory of Open Access Journals (Sweden)

    Elin Bjørge Løken

    2009-10-01

    Full Text Available  SAMMENDRAGEt selvadministrert spørreskjema om utvalgte sider av det vanlige kostholdet er besvart av ca. 60 000 mennog kvinner i de tre første hjerte-karundersøkelsene i Finnmark, Sogn og Fjordane og Oppland (1974-1988.Sammenligning av kostdata hos et utvalg av deltakerne som både besvarte spørreskjemaet og et 24 timerskostintervju, har vist at spørreskjemaet ikke bare ga et brukbart bilde av forbruket av melk, brød,smør/margarin og kaffe, men også for beregnet inntak av energi, protein, fett og kalsium. Skjemaetinneholdt få spørsmål om friske plantematvarer og kan derfor ikke gi data for inntak av antioksidanter.Resultatene viste klare forskjeller i kostholdet mellom menn og kvinner og i forhold til bosted. Videreanalyser har vist statistisk signifikante sammenhenger mellom en eller flere kostkomponenter og risiko forulike typer kreft og lårhalsbrudd. Materialet omfatter en forholdsvis ung kohorte, og kan på sikt væreinteressant for studier av andre sykdommer eller dødsårsaker som antas å ha sammenheng med en ellerflere av de kostkomponentene som spørreskjemaet omfatter. Ved vurdering av resultatene er det viktig å tahensyn til at spørreskjemaet ikke omfattet det totale kostholdet.Løken EB, Solvoll K. Can dietary data from the cardiovascular disease studies in Finnmark,Sogn og Fjordane and Oppland be used to analyse risk for other diseases?Nor J Epidemiol ENGLISH SUMMARYA self-administered questionnaire covering selected aspects of the habitual diet was answered byapproximately 60 000 men and women who participated in the three first screenings of cardiovasculardisease risk factors in the counties of Finnmark, Sogn og Fjordane and Oppland (1974-1988. A subsampleof the subjects was in addition interviewed about their intake of foods and beverages on the day before thequestionnaire was handed out. It appeared that the questionnaire not only provided reasonable data onconsumption of milk, bread, butter/margarine and

  4. Video coding standards AVS China, H.264/MPEG-4 PART 10, HEVC, VP6, DIRAC and VC-1

    CERN Document Server

    Rao, K R; Hwang, Jae Jeong

    2014-01-01

    Review by Ashraf A. Kassim, Professor, Department of Electrical & Computer Engineering, and Associate Dean, School of Engineering, National University of Singapore.     The book consists of eight chapters of which the first two provide an overview of various video & image coding standards, and video formats. The next four chapters present in detail the Audio & video standard (AVS) of China, the H.264/MPEG-4 Advanced video coding (AVC) standard, High efficiency video coding (HEVC) standard and the VP6 video coding standard (now VP10) respectively. The performance of the wavelet based Dirac video codec is compared with H.264/MPEG-4 AVC in chapter 7. Finally in chapter 8, the VC-1 video coding standard is presented together with VC-2 which is based on the intra frame coding of Dirac and an outline of a H.264/AVC to VC-1 transcoder.   The authors also present and discuss relevant research literature such as those which document improved methods & techniques, and also point to other related reso...

  5. PROLONGED MULTIPLE SPASMS OF SMOOTH CORONARY ARTERIES PRESENTING AS ACUTE MIOCARDIAL INFARCTION, COMPLETE AV BLOCK AND SYNCOPE

    Directory of Open Access Journals (Sweden)

    Franci Cesar

    2004-11-01

    Full Text Available Background. A variant form of angina pectoris (VAP is caused by coronary vessel spasm and occures in patients with and without varying degrees of obstructive coronary artery disease. Although the prognosis of VAP without significant organic stenosis is generally good, multivessel spasm is associated with a high risk of life-threatening abnormalities of rhythm and conduction.Patient and methods. We describe a patient who presented with prolonged chest pain, associated with hypotension, lost of consciousness, complete AV block and widespread ST segment elevations consistent with inferoanterior acute myocardial infarction. Urgent selective coronary angiography revealed spasms in right coronary artery and in left circumflex artery that were relieved by intracoronary injection of nitroglycerin. All coronary arteries were otherwise patient, without signs of atherosclerosis. The patient was treated with diltiazem and nitrates. She made a complete recovery and resumed her normal activities.Conclusions. Simultaneous multiple spasms of native coronary arteries represent a rare syndrome characterized by significantly higher incidence of potentially life-threatening arrhythmia. Less commonly, prolonged coronary spasm may mimic acute myocardial infarction. Modern management of acute coronary syndromes, including urgent coronarography, enables a prompt differentiation between prolonged coronary spasm and atherosclerotic coronary disease, warranting different treatment strategies. Medical treatment with nitrates and calcium channel blockers in most cases prevents recurrence of vasospasms and arrhythmias.

  6. Redovisning till verkligt värde : En studie om IAS 40:s inverkan på aktievärderingen av noterade fastighetföretag på Stockholmsbörsen

    OpenAIRE

    Sjögren, Andreas

    2007-01-01

    De senaste decenniernas globalisering har medfört att redovisningen behöver bli mer harmoniserad. Både företag och användare av redovisningsinformation är idag i större behov av att kunna jämföra redovisningsinformation inte bara mellan företag nationellt utan även mellan länder och mellan världsdelar. Detta är bakgrunden till införandet av IASB: s redovisningsregler i hela EU. En av de standarder som har påverkats mest av införandet av IASB: s regler benämnda IFRS/IAS är redovisningsstandard...

  7. Mitigation of methane emissions in a pilot-scale biocover system at the av miljø landfill, denmark: system design and gas distribution

    DEFF Research Database (Denmark)

    Kjeldsen, Peter; Skov, B.; Cassini, Filippo

    2013-01-01

    -passive biocover system was constructed at the AV Miljø landfill. The biocover is fed by landfill gas pumped out of three leachate wells. An innovative gas distribution system was used to overcome the often observed overloaded hot spot areas resulting from uneven gas distribution to the active methane oxidation...

  8. Mitigation of methane emissions in a pilot-scale biocover system at the AV Miljø Landfill, Denmark: 2. Methane oxidation

    DEFF Research Database (Denmark)

    Scheutz, Charlotte; Cassini, Filippo; De Schoenmaeker, Jan

    2017-01-01

    semi-passive biocover system was constructed at the AV Miljø Landfill, Denmark. The biocover was fed by landfill gas pumped out of three leachate collection wells. An innovative gas distribution system was used to overcome the often observed uneven gas distribution to the active CH4 oxidation layer...

  9. Systém ScholarOne a jeho využití redakcemi časopisů v AV ČR

    Czech Academy of Sciences Publication Activity Database

    Meixner, Jaroslav

    -, č. 4 (2015) E-ISSN 1805-2800 Keywords : peer review online system * ScholarOne * Academy of Sciences Library Subject RIV: AF - Documentation, Librarianship, Information Studies https://www.lib.cas.cz/casopis-informace/scholarone-a-vyuziti-redakcemi-casopisu-v-av-cr/

  10. Transvenous cold mapping and cryoablation of the AV node in dogs: observations of chronic lesions and comparison to those obtained using radiofrequency ablation

    NARCIS (Netherlands)

    Rodriguez, L. M.; Leunissen, J.; Hoekstra, A.; Korteling, B. J.; Smeets, J. L.; Timmermans, C.; Vos, M.; Daemen, M.; Wellens, H. J.

    1998-01-01

    Radiofrequency (RF) is the most commonly used energy source for the treatment of cardiac arrhythmias. Surgical experience has shown that cryoablation also is effective for ablating arrhythmias. The aims of this study were to (1) investigate the feasibility of inducing permanent complete AV block

  11. Effects of AV119, a natural sugar from avocado, on Malassezia furfur invasiveness and on the expression of HBD-2 and cytokines in human keratinocytes.

    Science.gov (United States)

    Donnarumma, Giovanna; Buommino, Elisabetta; Baroni, Adone; Auricchio, Lucia; De Filippis, Anna; Cozza, Valentina; Msika, Philippe; Piccardi, Nathalie; Tufano, Maria Antonietta

    2007-11-01

    AV119 is a patented blend of two sugars from avocado that can induce human beta-defensin-2 production by normal human keratinocytes. In this study, we analysed the effect of AV119 on growth and invasiveness of Malassezia furfur, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora. The ability to modulate the expression of the proinflammatory and immunomodulatory cytokines in normal human keratinocytes was also investigated. Microbiological assay demonstrated that this sugar induced the aggregation of yeast cells and inhibited the invasiveness of M. furfur, without affecting its growth. Real-time PCR analysis demonstrated that AV119 was able to modulate the HBD-2 response in treated keratinocytes, reaching a maximum after 48-h treatment, and to induce the recovery of a satisfactory proinflammatory response in human keratinocytes. As AV119 can induce aggregation of yeast cells, thus inhibiting their penetration into the keratinocytes, the sugar could be used in the preparation of cosmetics or pharmacological drugs to inhibit colonization of the skin by pathogenic strains of M. furfur.

  12. The risk assessment of heavy metals in Futian mangrove forest sediment in Shenzhen Bay (South China) based on SEM-AVS analysis.

    Science.gov (United States)

    Chai, Minwei; Shen, Xiaoxue; Li, Ruili; Qiu, Guoyu

    2015-08-15

    The risks of heavy metal in Futian mangrove forest sediment were assessed using the acid-volatile sulfide (AVS) and simultaneously extracted metals (SEM) methods. The results indicated that AVS distributions were more variable than the SEM distributions at all 16 sampling sites. The positive correlation between AVS and SEM indicated that their similar formative and existing conditions and that AVS acted as an important carrier for SEM. The major SEM component was Zn (69.7.3-94.2%), whereas the Cd contribution (the most toxic metal present) to SEM was no more than 1%. The possible adverse effects caused by heavy metals at ten sampling sites may be due to higher levels of SEMs, rather than AVSs. The total organic carbon (TOC) was an important metal-binding phase in the sediments. Taking into account the TOC concentration, there were no adverse effects due to heavy metals in any of the Futian mangrove forest sediments. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Test-retest reliabilitet av en anaerob terskeltest i felt. Undersøke test-retest reliabiliteten mellom ulike dager for en anaerob terskel test i felt.

    OpenAIRE

    Munkebye, Øyvind Bruhn

    2013-01-01

    Hensikten med dette studiet var å teste test-retest reliabilitet på en anaerob terskeltest i felt kun ved hjelp av hjertefrekvens. Resultatet fra undersøkelsen viste meget høy korrelasjon mellom anaerob terskel test 1 og anaerob terskeltest 2.

  14. Apolipoprotein A-V Deficiency Results in MarkedHypertriglyceridemia Attributable to Decreased Lipolysis ofTriglyceride-Rich Lipoproteins and Removal of Their Remnants

    Energy Technology Data Exchange (ETDEWEB)

    Grosskopf, Itamar; Baroukh, Nadine; Lee, Sung-Joon; Kamari,Yehuda; Harats, Dror; Rubin, Edward M.; Pennacchio, Len A.; Cooper, AllenD.

    2005-09-01

    Objective--ApoAV, a newly discovered apoprotein, affectsplasma triglyceride level. To determine how this occurs, we studiedtriglyceride-rich lipoprotein (TRL) metabolism in mice deficient inapoAV. Methods and Results No significant difference in triglycerideproduction rate was found between apoa5_/_ mice and controls. Thepresence or absence of apoAV affected TRL catabolism. After the injectionof 14C-palmitate and 3H-cholesterol labeled chylomicrons and 125I-labeledchylomicron remnants, the disappearance of 14C, 3H, and 125I wassignificantly slower in apoa5_/_ mice relative to controls. This wasbecause of diminished lipolysis of TRL and the reduced rate of uptake oftheir remnants in apoa5_/_ mice. Observed elevated cholesterol level wascaused by increased high-density lipoprotein (HDL) cholesterol inapoa5_/_ mice. VLDL from apoa5_/_ mice were poor substrate forlipoprotein lipase, and did not bind to the low-density lipoprotein (LDL)receptor as well as normal very-low-density lipoprotein (VLDL). LDLreceptor levels were slightly elevated in apoa5_/_ mice consistent withlower remnant uptake rates. These alterations may be the result of thelower apoE-to-apoC ratio found in VLDL isolated from apoa5_/_mice.Conclusions These results support the hypothesis that the absence ofapoAV slows lipolysis of TRL and the removal of their remnants byregulating their apoproteins content after secretion.

  15. Comparison of 99mTc-TRODAT-1 SPECT and 18 F-AV-133 PET imaging in healthy controls and Parkinson's disease patients.

    Science.gov (United States)

    Hsiao, Ing-Tsung; Weng, Yi-Hsin; Lin, Wey-Yil; Hsieh, Chia-Ju; Wey, Shiaw-Pyng; Yen, Tzu-Chen; Kung, Mei-Ping; Lu, Chin-Song; Lin, Kun-Ju

    2014-04-01

    (99m)Tc-TRODAT-1 is the first clinical routine (99m)Tc radiopharmaceutical to evaluate dopamine neurons loss in Parkinson's disease (PD). (18)F-AV-133 is a novel PET radiotracer targeting the vesicular monoamine transporter type 2 (VMAT2) to detect monoaminergic terminal reduction in PD patients. The aim of this study is to compare both images in the same health control (HC) and PD subjects. Eighteen subjects (8 HC and 10 PD) were recruited for (99m)Tc-TRODAT-1 SPECT, (18)F-AV-133 PET and MRI scans within two weeks. The SPECT images were performed at 4-h post-injection for 45 min, and the PET images were performed at 90 min post-injection for 10 min. Each PET and SPECT image was normalized into Montreal Neurological Institute template aided from individual MRI for comparison. For regional analysis, volume of interest (VOIs) of bilateral caudate nuclei, anterior, posterior putamen and occipital cortex (as reference region) were delineated from the normalized MRI. The specific uptake ratio (SUR) was calculated as (regional mean counts/reference mean counts-1). The nonparametric Mann-Whitney U test was used to evaluate the power of differentiating control from PD subjects for both image modalities. The correlations of the SURs to the clinical parameters were examined. For voxelwise analysis, two-sample t-test for group comparison between HC and PD was computed in both image modalities. The SURs of caudate nucleus and putamen correlated well between two image modalities (r = 0.81, pAV-133 SUR displayed a better correlation to PD clinical laterality index as compared to (99m)Tc-TRODAT-1 (r = 0.73 vs. r = 0.33). Voxelwise analysis showed more lesions for PD subjects from (18)F-AV-133 image as compared to (99m)Tc-TRODAT-1 especially at the substantia nigra region. (18)F-AV-133 PET demonstrated similar performance in differentiation PD from control, and a better correlation to clinical characteristics than that of (99m)Tc-TRODAT-1 SPECT. (18)F-AV-133 PET also showed

  16. Comparison between IEGM-based approach and echocardiography in AV/PV and VV delay optimization in CRT-D recipients (Quicksept study).

    Science.gov (United States)

    Giammaria, Massimo; Quirino, Gianluca; Cecchi, Enrico; Senatore, Gaetano; Pistelli, Paolo; Bocchiardo, Mario; Mureddu, Roberto; Diotallevi, Paolo; Occhetta, Eraldo; Magnani, Andrea; Bensoni, Mauro; Checchinato, Catia; Conti, Valentina; Badolati, Sandra; Mazza, Antonio

    2016-01-01

    AtrioVentricular (AV) and InterVentricular (VV) delay optimization can improve ventricular function in Cardiac Resynchronization Therapy (CRT) and is usually performed by means of echocardiography. St Jude Medical has developed an automated algorhythm which calculates the optimal AV and VV delays (QuickOpt™) based on Intracardiac ElectroGrams, (IEGM), within 2 min. So far, the efficacy of the algorhythm has been tested acutely with standard lead position at right ventricular (RV) apex. Aim of this project is to evaluate the algorhythm performance in the mid- and long-term with RV lead located in mid-septum. AV and VV delays optimization data were collected in 13 centers using both echocardiographic and QuickOpt™ guidance in CRTD implanted patients provided with this algorhythm. Measurements of the aortic Velocity Time Integral (aVTI) were performed with both methods in a random order at pre-discharge, 6-month and 12-month follow-up. Fifty-three patients were studied (46 males; age 68 ± 10y; EF 28 ± 7%). Maximum aVTI obtained by echocardiography at different AV delays, were compared with aVTI acquired at AV delays suggested by QuickOpt. The AV Pearson correlations were 0.96 at pre-discharge, 0.95 and 0,98 at 6- and 12- month follow-up respectively. After programming optimal AV, the same approach was used to compare echocardiographic aVTI with aVTI corresponding to the VV values provided by QuickOpt. The VV Pearson Correlation were 0,92 at pre-discharge, 0,88 and 0.90 at 6-month and 12- month follow-up respectively. IEGM-based optimization provides comparable results with echocardiographic method (maximum aVTI) used as reference with mid-septum RV lead location. Copyright © 2016 Indian Heart Rhythm Society. Production and hosting by Elsevier B.V. All rights reserved.

  17. Er konsum av melk og egg assosiert med risiko for kreft? Foreløpige resultater fra en prospektiv undersøkelse

    Directory of Open Access Journals (Sweden)

    Grethe Albrektsen

    2009-10-01

    Full Text Available  SAMMENDRAGSammenhenger mellom kreftinsidens og konsum av egg og melk er studert i en prospektiv undersøkelse avca. 50 000 personer i alderen 30-69 år. Kostholdsdataene ble samlet inn i forbindelse med andre runde avhjerte- og karundersøkelsene som ble gjennomført av Statens helseundersøkelser i Finnmark, Sogn ogFjordane og Oppland i perioden 1977-83. Gjennomsnittlig oppfølgingstid var 11,8 år. Omlag 2000 personerfikk en kreftdiagnose i løpet av oppfølgingsperioden. Insidensrate-ratioer er beregnet i en log-lineærPoissonregresjon basert på personår under risiko. Vi fant ingen sammenheng mellom total kreftinsidens ogkonsum av melk (glass pr. dag eller egg (antall pr. uke, men for spesifikke krefttyper observerte vi enkelteassosiasjoner. Det arbeides nå med mer detaljerte analyser og med internasjonal publisering av resultatene.Albrektsen G, Heuch I, Jacobsen BK, Kvåle G. Is milk and egg consumption associated with cancerrisk? Preliminary results from a prospective study. Nor J Epidemiol 1997; 7 (2: 205-208.ENGLISH SUMMARYAssociations between cancer incidence and consumption of milk and eggs were examined in a prospectivestudy of about 50,000 persons aged 30-69 years. The mean follow-up period was 11.8 years. About 2000persons were diagnosed with cancer during follow-up. Incidence rate ratios were calculated in a log-linearPoisson regression model of person-years at risk. No relations were found between overall cancer incidenceand consumption of milk (glasses per day or eggs (number per week, but some associations were observedfor specific sites. The analysis of the data is in progress and the results presented are preliminary.

  18. Naturvetenskap för yngre barn – kunskapsinnehåll i lärarstudenters beskrivningar av sin framtida undervisning

    Directory of Open Access Journals (Sweden)

    Anna T. Danielsson

    2018-02-01

    Full Text Available Syftet med artikeln är att utforska vilket kunskapsinnehåll som lärarstudenter inriktade mot förskolan och grundskolans tidigare år framställer som centralt för undervisning av yngre barn i naturvetenskap. Detta utgår från antagandet att kunskap om lärarstudenters relation till naturvetenskap är en viktig del i naturvetenskapliga lärarutbildares ämnesdidaktiska kompetens. Studien använder Roberts (1982 kunskapsemfaser som ett analysverktyg för att tematisera vad lärarstudenter inriktade mot förskolan och grundskolans tidigare år framställer som centralt för naturvetenskaplig undervisning. Det empiriska materialet består av en essäuppgift där lärarstudenter (N=144 reflekterar över sina egna erfarenheter och upplevelser av naturvetenskap och naturvetenskaplig undervisning samt sin framtida undervisning. De två teman som allra starkast präglar essämaterialet är den starka fokuseringen på vardagsanknytning samt att grundlägga ett naturvetenskapligt intresse hos yngre elever, medan andra aspekter av naturvetenskaplig undervisning till stor del osynliggörs. Vi menar att det att utgå från lärarstudenternas beskrivningar av naturvetenskaplig undervisning kan vara stärkande (empowering för denna studentgrupp, då talet om förskollärares och tidigarelärares deltagande i naturvetenskapliga aktiviteter ofta fokuserar antingen brister i kunskaper eller i självförtroende.

  19. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.

    Science.gov (United States)

    Xia, Chenjie; Makaretz, Sara J; Caso, Christina; McGinnis, Scott; Gomperts, Stephen N; Sepulcre, Jorge; Gomez-Isla, Teresa; Hyman, Bradley T; Schultz, Aaron; Vasdev, Neil; Johnson, Keith A; Dickerson, Bradford C

    2017-04-01

    Previous postmortem studies have long demonstrated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated with Alzheimer disease clinical phenotype and neurodegeneration pattern. Validating these associations in vivo will lead to new diagnostic tools for Alzheimer disease and better understanding of its neurobiology. To examine whether topographical distribution and severity of hyperphosphorylated tau pathologic findings measured by fluorine 18-labeled AV-1451 ([18F]AV-1451) positron emission tomographic (PET) imaging are linked with clinical phenotype and cortical atrophy in patients with Alzheimer disease. This observational case series, conducted from July 1, 2012, to July 30, 2015, in an outpatient referral center for patients with neurodegenerative diseases, included 6 patients: 3 with typical amnesic Alzheimer disease and 3 with atypical variants (posterior cortical atrophy, logopenic variant primary progressive aphasia, and corticobasal syndrome). Patients underwent [18F]AV-1451 PET imaging to measure tau burden, carbon 11-labeled Pittsburgh Compound B ([11C]PiB) PET imaging to measure amyloid burden, and structural magnetic resonance imaging to measure cortical thickness. Seventy-seven age-matched controls with normal cognitive function also underwent structural magnetic resonance imaging but not tau or amyloid PET imaging. Tau burden, amyloid burden, and cortical thickness. In all 6 patients (3 women and 3 men; mean age 61.8 years), the underlying clinical phenotype was associated with the regional distribution of the [18F]AV-1451 signal. Furthermore, within 68 cortical regions of interest measured from each patient, the magnitude of cortical atrophy was strongly correlated with the magnitude of [18F]AV-1451 binding (3 patients with amnesic Alzheimer disease, r = -0.82; P Alzheimer disease, r = -0.51; P Alzheimer disease neuropathologic condition with clinically significant neurodegeneration, which will

  20. A randomized controlled trial comparing the AccuVein AV300 device to standard insertion technique for intravenous cannulation of anesthetized children.

    Science.gov (United States)

    Kaddoum, Roland N; Anghelescu, Doralina L; Parish, Mary E; Wright, Becky B; Trujillo, Luis; Wu, Jianrong; Wu, Yanan; Burgoyne, Laura L

    2012-09-01

    To evaluate the efficacy of the AccuVein AV300 device in improving the first-time success rate of intravenous cannulation of anesthetized pediatric patients. The AccuVein AV300 device was developed to assist venepuncture and intravenous cannulation by enhancing the visibility of superficial veins. It uses infrared light to highlight hemoglobin so that blood vessels are darkly delineated against a red background. Patients were randomized to cannulation with the AccuVein AV300 device or standard insertion by experienced pediatric anesthesiologists. An observer recorded the number of skin punctures and cannulation attempts required, and the time between tourniquet application and successful cannulation or four skin punctures, whichever came first. There were 146 patients with a median age of 4.6 years (range, 0.18-17.1 years), 46.6% were male, 80.8% were light skin colored, and 15.7% were younger than 2 years. The first-attempt success rates were 75% (95% CI, 63.8-84.2%) using AV300 and 73% (95% CI, 61.9-81.9%) using the standard method (P = 0.85). Patients with dark or medium skin color were 0.38 times less likely to have a successful first attempt than patients with light skin color. The difference between the two treatment groups in number of skin punctures and the time to insertion was not significant. Although the AV300 was easy to use and improved visualization of the veins, we found no evidence that it was superior to the standard method of intravenous cannulation in unselected pediatric patients under anesthesia. © 2012 Blackwell Publishing Ltd.